locus-tag	class	description
BBB50_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBB50_RS00010	COG0592	DNA-directed DNA polymerase activity
BBB50_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BBB50_RS00020	COG0187	DNA topoisomerase II activity
BBB50_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
BBB50_RS00040	COG3977	Valine--pyruvate aminotransferase
BBB50_RS00045	COG0751	glycine-tRNA ligase activity
BBB50_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
BBB50_RS00055	COG2119	membrane
BBB50_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
BBB50_RS00075	COG0604	alcohol dehydrogenase
BBB50_RS00085	COG0129	dihydroxy-acid dehydratase activity
BBB50_RS00090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBB50_RS00105	COG0606	chelatase, subunit chli
BBB50_RS00110	COG0204	Acyl-transferase
BBB50_RS00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBB50_RS00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BBB50_RS00130	COG3084	Protein conserved in bacteria
BBB50_RS00140	COG4326	sporulation control protein
BBB50_RS00145	COG1272	protein, Hemolysin III
BBB50_RS00155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBB50_RS00160	COG0569	domain protein
BBB50_RS00165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBB50_RS00165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBB50_RS00170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BBB50_RS00175	COG0242	peptide deformylase activity
BBB50_RS00180	COG1652	LysM domain
BBB50_RS00185	COG0758	DNA mediated transformation
BBB50_RS00190	COG2922	Belongs to the Smg family
BBB50_RS00195	COG0551	DNA topoisomerase type I activity
BBB50_RS00200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBB50_RS00205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BBB50_RS00210	COG0009	L-threonylcarbamoyladenylate synthase
BBB50_RS00215	COG0408	coproporphyrinogen oxidase activity
BBB50_RS00220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBB50_RS00230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BBB50_RS00275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BBB50_RS00280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BBB50_RS00290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BBB50_RS00295	COG2104	thiamine diphosphate biosynthetic process
BBB50_RS00300	COG2022	thiamine diphosphate biosynthetic process
BBB50_RS00305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BBB50_RS00310	COG0006	proline dipeptidase activity
BBB50_RS00310	COG0006	proline dipeptidase activity
BBB50_RS00330	COG1522	sequence-specific DNA binding
BBB50_RS00335	COG5002	protein histidine kinase activity
BBB50_RS00335	COG5001	Diguanylate cyclase
BBB50_RS00355	COG0589	response to stress
BBB50_RS00365	COG1528	Iron-storage protein
BBB50_RS00375	COG2081	HI0933 family
BBB50_RS00385	COG1322	Protein conserved in bacteria
BBB50_RS00390	COG2226	methyltransferase
BBB50_RS00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBB50_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBB50_RS00415	COG0805	protein transport
BBB50_RS00420	COG1858	cytochrome C peroxidase
BBB50_RS00425	COG0534	Mate efflux family protein
BBB50_RS00435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BBB50_RS00445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BBB50_RS00450	COG3161	chorismate lyase activity
BBB50_RS00460	COG1580	Controls the rotational direction of flagella during chemotaxis
BBB50_RS00465	COG0840	transmembrane signaling receptor activity
BBB50_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBB50_RS00485	COG0084	hydrolase, TatD family'
BBB50_RS00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBB50_RS00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBB50_RS00520	COG3078	GTPase activator activity
BBB50_RS00535	COG3071	HemY protein
BBB50_RS00540	COG2959	enzyme of heme biosynthesis
BBB50_RS00545	COG1587	Uroporphyrinogen-III synthase
BBB50_RS00550	COG0181	hydroxymethylbilane synthase activity
BBB50_RS00565	COG1965	Belongs to the frataxin family
BBB50_RS00575	COG0019	diaminopimelate decarboxylase activity
BBB50_RS00580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBB50_RS00590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BBB50_RS00595	COG1011	Hydrolase
BBB50_RS00600	COG3287	FIST C domain
BBB50_RS00600	COG2200	EAL domain
BBB50_RS00600	COG2199	diguanylate cyclase activity
BBB50_RS00620	COG0561	phosphatase activity
BBB50_RS00625	COG2267	carboxylic ester hydrolase activity
BBB50_RS00630	COG1280	lysine exporter protein (LysE YggA)
BBB50_RS00635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BBB50_RS00640	COG0783	Belongs to the Dps family
BBB50_RS00675	COG0742	ribosomal rna small subunit methyltransferase
BBB50_RS00680	COG0552	protein localization to endoplasmic reticulum
BBB50_RS00685	COG2884	Cell division ATP-binding protein ftsE
BBB50_RS00690	COG2177	Part of the ABC transporter FtsEX involved in
BBB50_RS00695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBB50_RS00700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_RS00715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBB50_RS00720	COG4206	TonB-dependent receptor
BBB50_RS00725	COG1404	Belongs to the peptidase S8 family
BBB50_RS00730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BBB50_RS00805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BBB50_RS00810	COG3300	MHYT domain
BBB50_RS00810	COG5001	Diguanylate cyclase
BBB50_RS00820	COG3852	Histidine kinase
BBB50_RS00830	COG0174	glutamine synthetase
BBB50_RS00840	COG1217	gtp-binding protein TYPA
BBB50_RS00850	COG1295	ribonuclease BN
BBB50_RS00855	COG1490	D-aminoacyl-tRNA deacylase activity
BBB50_RS00860	COG0456	acetyltransferase
BBB50_RS00870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BBB50_RS00875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BBB50_RS00880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BBB50_RS00885	COG3031	protein transport across the cell outer membrane
BBB50_RS00895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_RS00900	COG1459	type II secretion system
BBB50_RS00905	COG2165	general secretion pathway protein
BBB50_RS00910	COG2165	general secretion pathway protein
BBB50_RS00915	COG2165	general secretion pathway protein
BBB50_RS00920	COG4795	General secretion pathway protein
BBB50_RS00925	COG3156	type II secretion system protein K
BBB50_RS00930	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BBB50_RS00935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BBB50_RS00945	COG1218	3'(2'),5'-bisphosphate nucleotidase
BBB50_RS00950	COG0494	nUDIX hydrolase
BBB50_RS00960	COG1040	competence protein
BBB50_RS00965	COG0596	Alpha beta hydrolase
BBB50_RS00975	COG2183	response to ionizing radiation
BBB50_RS00980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBB50_RS00995	COG2233	PERMEase
BBB50_RS01000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BBB50_RS01005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBB50_RS01010	COG1758	RNA polymerase activity
BBB50_RS01015	COG0194	GDP metabolic process
BBB50_RS01020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BBB50_RS01025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBB50_RS01045	COG4232	protein-disulfide reductase activity
BBB50_RS01060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BBB50_RS01065	COG1027	Aspartate ammonia-lyase
BBB50_RS01070	COG3706	GGDEF domain
BBB50_RS01075	COG3030	protein affecting phage T7 exclusion by the F plasmid
BBB50_RS01080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBB50_RS01090	COG2205	protein histidine kinase activity
BBB50_RS01095	COG0745	RESPONSE REGULATOR receiver
BBB50_RS01105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BBB50_RS01110	COG0205	6-phosphofructokinase activity
BBB50_RS01115	COG1494	fructose-1,6-bisphosphatase
BBB50_RS01120	COG3074	FtsZ-dependent cytokinesis
BBB50_RS01125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBB50_RS01130	COG0460	homoserine dehydrogenase
BBB50_RS01130	COG0527	aspartate kinase activity
BBB50_RS01135	COG0626	cystathionine gamma-synthase activity
BBB50_RS01140	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BBB50_RS01145	COG0281	malic enzyme
BBB50_RS01150	COG0254	rRNA binding
BBB50_RS01155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBB50_RS01160	COG1609	Transcriptional regulator
BBB50_RS01165	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BBB50_RS01170	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BBB50_RS01175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BBB50_RS01180	COG1575	Belongs to the MenA family. Type 1 subfamily
BBB50_RS01185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BBB50_RS01190	COG0534	Mate efflux family protein
BBB50_RS01195	COG0149	triose-phosphate isomerase activity
BBB50_RS01220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBB50_RS01225	COG0459	protein refolding
BBB50_RS01235	COG1509	lysine 2,3-aminomutase activity
BBB50_RS01240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBB50_RS01250	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BBB50_RS01255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBB50_RS01260	COG1053	succinate dehydrogenase
BBB50_RS01265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BBB50_RS01270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBB50_RS01275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BBB50_RS01280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BBB50_RS01285	COG1045	serine acetyltransferase
BBB50_RS01295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BBB50_RS01300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBB50_RS01305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BBB50_RS01310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BBB50_RS01315	COG0137	argininosuccinate synthase activity
BBB50_RS01320	COG0165	Argininosuccinate lyase
BBB50_RS01330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_RS01335	COG0678	peroxiredoxin activity
BBB50_RS01335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBB50_RS01345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBB50_RS01365	COG3778	Protein conserved in bacteria
BBB50_RS01370	COG3299	homolog of phage Mu protein gp47
BBB50_RS01380	COG4384	Bacteriophage Mu Gp45 protein
BBB50_RS01400	COG3941	tape measure
BBB50_RS01415	COG4386	tail sheath protein
BBB50_RS01435	COG4387	Mu-like prophage protein GP36
BBB50_RS01445	COG4397	Mu-like prophage major head subunit gpT
BBB50_RS01480	COG4383	Mu-like prophage protein gp29
BBB50_RS01485	COG4373	Mu-like prophage FluMu protein gp28
BBB50_RS01495	COG0640	Transcriptional regulator
BBB50_RS01610	COG2842	Transposition protein
BBB50_RS01615	COG2801	Transposase and inactivated derivatives
BBB50_RS01620	COG3423	Transcriptional regulator
BBB50_RS01655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BBB50_RS01660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BBB50_RS01670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BBB50_RS01675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBB50_RS01680	COG0546	phosphoglycolate phosphatase activity
BBB50_RS01685	COG0180	Tryptophanyl-tRNA synthetase
BBB50_RS01700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBB50_RS01710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBB50_RS01735	COG3954	Phosphoribulokinase
BBB50_RS01745	COG0429	hydrolase of the alpha beta-hydrolase fold
BBB50_RS01755	COG0488	(ABC) transporter
BBB50_RS01760	COG2249	NAD(P)H dehydrogenase (quinone) activity
BBB50_RS01775	COG1047	Peptidyl-prolyl cis-trans
BBB50_RS01790	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BBB50_RS01795	COG3083	sulfuric ester hydrolase activity
BBB50_RS01800	COG0557	exoribonuclease II activity
BBB50_RS01805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBB50_RS01810	COG0051	transcription antitermination factor activity, RNA binding
BBB50_RS01815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BBB50_RS01820	COG0088	Forms part of the polypeptide exit tunnel
BBB50_RS01825	COG0089	rRNA binding
BBB50_RS01830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BBB50_RS01835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BBB50_RS01840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BBB50_RS01845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BBB50_RS01850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BBB50_RS01855	COG0255	Belongs to the universal ribosomal protein uL29 family
BBB50_RS01860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BBB50_RS01865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BBB50_RS01870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BBB50_RS01875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BBB50_RS01880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBB50_RS01885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BBB50_RS01895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BBB50_RS01900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BBB50_RS01905	COG1841	ribosomal large subunit assembly
BBB50_RS01915	COG0201	protein transport
BBB50_RS01920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBB50_RS01925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BBB50_RS01930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BBB50_RS01935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BBB50_RS01940	COG0202	RNA polymerase activity
BBB50_RS01945	COG0203	ribosomal protein L17
BBB50_RS01955	COG0545	Peptidyl-prolyl cis-trans isomerase
BBB50_RS01960	COG3061	Opacity-associated protein A
BBB50_RS01960	COG3266	domain, Protein
BBB50_RS01965	COG0697	spore germination
BBB50_RS01970	COG2153	protein acetylation
BBB50_RS01975	COG0513	Belongs to the DEAD box helicase family
BBB50_RS01985	COG0737	Belongs to the 5'-nucleotidase family
BBB50_RS01990	COG1648	precorrin-2 dehydrogenase activity
BBB50_RS01990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BBB50_RS02005	COG0529	Catalyzes the synthesis of activated sulfate
BBB50_RS02025	COG1136	(ABC) transporter
BBB50_RS02040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BBB50_RS02045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_RS02050	COG0729	surface antigen
BBB50_RS02060	COG2105	PFAM AIG2 family protein
BBB50_RS02065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBB50_RS02080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBB50_RS02085	COG0163	prenyltransferase activity
BBB50_RS02095	COG1178	ABC-type Fe3 transport system permease component
BBB50_RS02100	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BBB50_RS02105	COG3028	Belongs to the UPF0307 family
BBB50_RS02110	COG0312	modulator of DNA gyrase
BBB50_RS02115	COG2239	Acts as a magnesium transporter
BBB50_RS02120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_RS02125	COG1660	Displays ATPase and GTPase activities
BBB50_RS02130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_RS02135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBB50_RS02145	COG1137	ATPase activity
BBB50_RS02150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BBB50_RS02165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BBB50_RS02165	COG0517	IMP dehydrogenase activity
BBB50_RS02180	COG1127	ABC transporter
BBB50_RS02185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BBB50_RS02190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BBB50_RS02195	COG2854	intermembrane phospholipid transfer
BBB50_RS02205	COG5007	Belongs to the BolA IbaG family
BBB50_RS02210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBB50_RS02220	COG0251	oxidation-reduction process
BBB50_RS02230	COG0540	Belongs to the ATCase OTCase family
BBB50_RS02245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BBB50_RS02260	COG0564	pseudouridine synthase activity
BBB50_RS02265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBB50_RS02270	COG0525	valine-tRNA ligase activity
BBB50_RS02275	COG2927	DNA polymerase III (CHI subunit)
BBB50_RS02280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBB50_RS02285	COG0795	lipopolysaccharide-transporting ATPase activity
BBB50_RS02290	COG0795	lipopolysaccharide-transporting ATPase activity
BBB50_RS02305	COG3437	response regulator, receiver
BBB50_RS02350	COG0066	3-isopropylmalate dehydratase activity
BBB50_RS02355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BBB50_RS02360	COG0473	3-isopropylmalate dehydrogenase activity
BBB50_RS02385	COG0583	DNA-binding transcription factor activity
BBB50_RS02390	COG1022	Amp-dependent synthetase and ligase
BBB50_RS02395	COG0028	Belongs to the TPP enzyme family
BBB50_RS02400	COG0440	acetolactate synthase activity
BBB50_RS02405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBB50_RS02410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BBB50_RS02415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBB50_RS02425	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BBB50_RS02430	COG3079	Belongs to the UPF0149 family
BBB50_RS02435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_RS02440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_RS02455	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BBB50_RS02465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BBB50_RS02475	COG1595	DNA-templated transcription, initiation
BBB50_RS02490	COG3086	response to oxidative stress
BBB50_RS02495	COG0481	GTPase activity
BBB50_RS02510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BBB50_RS02515	COG1381	Involved in DNA repair and RecF pathway recombination
BBB50_RS02520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BBB50_RS02540	COG5001	Diguanylate cyclase
BBB50_RS02555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBB50_RS02560	COG3956	TIGRFAM MazG family protein
BBB50_RS02565	COG0504	CTP synthase activity
BBB50_RS02570	COG0148	phosphopyruvate hydratase activity
BBB50_RS02580	COG3267	Type II secretory pathway component ExeA
BBB50_RS02580	COG3409	Peptidoglycan-binding domain 1 protein
BBB50_RS02595	COG0306	phosphate transporter
BBB50_RS02600	COG1392	Phosphate transport regulator
BBB50_RS02605	COG3025	triphosphatase activity
BBB50_RS02610	COG0840	transmembrane signaling receptor activity
BBB50_RS02615	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BBB50_RS02625	COG1538	Outer membrane efflux protein
BBB50_RS02630	COG0494	nUDIX hydrolase
BBB50_RS02635	COG3151	Protein conserved in bacteria
BBB50_RS02645	COG3150	esterase
BBB50_RS02650	COG0187	DNA topoisomerase II activity
BBB50_RS02655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBB50_RS02665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BBB50_RS02670	COG0237	dephospho-CoA kinase activity
BBB50_RS02680	COG1459	type II secretion system
BBB50_RS02685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_RS02705	COG0716	FMN binding
BBB50_RS02710	COG4974	Belongs to the 'phage' integrase family
BBB50_RS02715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBB50_RS02720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BBB50_RS02725	COG0737	Belongs to the 5'-nucleotidase family
BBB50_RS02730	COG2186	Transcriptional regulator
BBB50_RS02735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BBB50_RS02740	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBB50_RS02745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_RS02760	COG3116	cell division
BBB50_RS02765	COG0768	penicillin binding
BBB50_RS02770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BBB50_RS02775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBB50_RS02785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BBB50_RS02790	COG0772	Belongs to the SEDS family
BBB50_RS02800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBB50_RS02805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BBB50_RS02810	COG0849	cell division
BBB50_RS02815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBB50_RS02820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BBB50_RS02830	COG0653	protein targeting
BBB50_RS02840	COG0494	nUDIX hydrolase
BBB50_RS02845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BBB50_RS02855	COG0505	Belongs to the CarA family
BBB50_RS02860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BBB50_RS02880	COG4172	Belongs to the ABC transporter superfamily
BBB50_RS02890	COG0730	response to heat
BBB50_RS02895	COG0583	DNA-binding transcription factor activity
BBB50_RS02900	COG2860	membrane
BBB50_RS02905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BBB50_RS02915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BBB50_RS02925	COG0493	'glutamate synthase
BBB50_RS02930	COG0069	glutamate synthase activity
BBB50_RS02930	COG0067	glutamate synthase
BBB50_RS02930	COG0070	glutamate synthase
BBB50_RS02940	COG0069	glutamate synthase activity
BBB50_RS02940	COG0067	glutamate synthase
BBB50_RS02940	COG0070	glutamate synthase
BBB50_RS02945	COG1242	4 iron, 4 sulfur cluster binding
BBB50_RS02950	COG5001	Diguanylate cyclase
BBB50_RS02950	COG4251	negative regulation of phosphorylation
BBB50_RS02950	COG3706	GGDEF domain
BBB50_RS02950	COG2203	Gaf domain
BBB50_RS02955	COG5002	protein histidine kinase activity
BBB50_RS02955	COG2198	Histidine kinase
BBB50_RS02955	COG0784	Response regulator, receiver
BBB50_RS02960	COG0745	RESPONSE REGULATOR receiver
BBB50_RS02970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BBB50_RS02990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BBB50_RS02995	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BBB50_RS03000	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BBB50_RS03005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BBB50_RS03020	COG1115	amino acid carrier protein
BBB50_RS03025	COG3022	response to hydroperoxide
BBB50_RS03030	COG0084	hydrolase, TatD family'
BBB50_RS03035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BBB50_RS03045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BBB50_RS03050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BBB50_RS03055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BBB50_RS03060	COG0813	purine-nucleoside phosphorylase activity
BBB50_RS03070	COG0560	Phosphoserine phosphatase
BBB50_RS03080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BBB50_RS03085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BBB50_RS03090	COG1022	Amp-dependent synthetase and ligase
BBB50_RS03110	COG1609	Transcriptional regulator
BBB50_RS03115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_RS03130	COG0569	domain protein
BBB50_RS03130	COG0189	ligase activity
BBB50_RS03135	COG0456	acetyltransferase
BBB50_RS03145	COG2171	N-acyltransferase activity
BBB50_RS03150	COG3141	response to X-ray
BBB50_RS03165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BBB50_RS03170	COG1074	ATP-dependent DNA helicase activity
BBB50_RS03175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBB50_RS03190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BBB50_RS03190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BBB50_RS03200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BBB50_RS03205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BBB50_RS03210	COG2166	iron-sulfur cluster assembly
BBB50_RS03215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBB50_RS03220	COG0693	protein deglycase activity
BBB50_RS03225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBB50_RS03230	COG3248	Nucleoside-binding outer membrane protein
BBB50_RS03240	COG1595	DNA-templated transcription, initiation
BBB50_RS03250	COG2211	Major facilitator Superfamily
BBB50_RS03255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBB50_RS03265	COG2813	Specifically methylates the guanine in position
BBB50_RS03270	COG0271	Belongs to the BolA IbaG family
BBB50_RS03275	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_RS03280	COG1805	sodium ion transport
BBB50_RS03285	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_RS03290	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_RS03295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBB50_RS03300	COG2871	sodium ion transport
BBB50_RS03305	COG1477	protein flavinylation
BBB50_RS03325	COG3706	GGDEF domain
BBB50_RS03330	COG0733	neurotransmitter:sodium symporter activity
BBB50_RS03340	COG0189	ligase activity
BBB50_RS03345	COG0189	ligase activity
BBB50_RS03345	COG4067	protein conserved in archaea
BBB50_RS03350	COG2195	Cleaves the N-terminal amino acid of tripeptides
BBB50_RS03355	COG2252	PERMEase
BBB50_RS03360	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BBB50_RS03365	COG1073	alpha beta
BBB50_RS03375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BBB50_RS03380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BBB50_RS03385	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBB50_RS03390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBB50_RS03390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBB50_RS03405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BBB50_RS03410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBB50_RS03415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BBB50_RS03420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BBB50_RS03430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBB50_RS03435	COG0024	Methionine aminopeptidase
BBB50_RS03440	COG0052	Belongs to the universal ribosomal protein uS2 family
BBB50_RS03445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BBB50_RS03450	COG0528	UMP kinase activity
BBB50_RS03455	COG0233	cytoplasmic translational termination
BBB50_RS03460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BBB50_RS03465	COG0575	Belongs to the CDS family
BBB50_RS03470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BBB50_RS03475	COG0750	zinc metalloprotease
BBB50_RS03485	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BBB50_RS03490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_RS03495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BBB50_RS03500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_RS03505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_RS03510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBB50_RS03515	COG0587	DNA-directed DNA polymerase activity
BBB50_RS03520	COG0825	malonyl-CoA metabolic process
BBB50_RS03525	COG0037	tRNA processing
BBB50_RS03535	COG3479	Phenolic acid decarboxylase
BBB50_RS03540	COG0347	Belongs to the P(II) protein family
BBB50_RS03545	COG3021	interspecies interaction between organisms
BBB50_RS03550	COG0741	lytic transglycosylase activity
BBB50_RS03550	COG1388	LysM domain
BBB50_RS03555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBB50_RS03560	COG2226	methyltransferase
BBB50_RS03565	COG0328	RNA-DNA hybrid ribonuclease activity
BBB50_RS03580	COG1960	acyl-CoA dehydrogenase activity
BBB50_RS03585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BBB50_RS03590	COG0121	glutamine amidotransferase
BBB50_RS03595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BBB50_RS03600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BBB50_RS03605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BBB50_RS03615	COG1187	pseudouridine synthase activity
BBB50_RS03620	COG2840	Smr protein MutS2
BBB50_RS03635	COG3735	TraB family
BBB50_RS03650	COG2608	mercury ion transmembrane transporter activity
BBB50_RS03650	COG2217	Heavy metal translocating P-type atpase
BBB50_RS03655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BBB50_RS03670	COG4774	siderophore transport
BBB50_RS03670	COG1629	transport
BBB50_RS03675	COG2375	cellular response to nickel ion
BBB50_RS03680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBB50_RS03680	COG3433	isochorismatase activity
BBB50_RS03680	COG2226	methyltransferase
BBB50_RS03715	COG0784	Response regulator, receiver
BBB50_RS03715	COG0835	chemotaxis
BBB50_RS03720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BBB50_RS03725	COG1815	bacterial-type flagellum-dependent cell motility
BBB50_RS03740	COG1749	Flagellar hook protein flgE
BBB50_RS03745	COG4787	bacterial-type flagellum-dependent cell motility
BBB50_RS03755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BBB50_RS03760	COG1706	bacterial-type flagellum-dependent cell motility
BBB50_RS03765	COG1705	Flagellar rod assembly protein muramidase FlgJ
BBB50_RS03765	COG3951	Flagellar rod assembly protein muramidase FlgJ
BBB50_RS03785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_RS03790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_RS03875	COG0012	GTP binding
BBB50_RS03880	COG0193	aminoacyl-tRNA hydrolase activity
BBB50_RS03885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BBB50_RS03890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BBB50_RS03895	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BBB50_RS03900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BBB50_RS03905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBB50_RS03910	COG2890	protein-(glutamine-N5) methyltransferase activity
BBB50_RS03920	COG2912	Transglutaminase-like superfamily
BBB50_RS03925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BBB50_RS03930	COG0737	Belongs to the 5'-nucleotidase family
BBB50_RS03935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBB50_RS03940	COG2233	PERMEase
BBB50_RS03960	COG1393	Belongs to the ArsC family
BBB50_RS03965	COG4783	chaperone-mediated protein folding
BBB50_RS03985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BBB50_RS04000	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BBB50_RS04010	COG1876	peptidase activity
BBB50_RS04020	COG1393	Belongs to the ArsC family
BBB50_RS04040	COG2837	iron assimilation
BBB50_RS04045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_RS04050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_RS04055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_RS04060	COG1334	flagellar protein FlaG
BBB50_RS04065	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BBB50_RS04075	COG1516	flagellar protein fliS
BBB50_RS04095	COG1677	Flagellar hook-basal body complex protein FliE
BBB50_RS04105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BBB50_RS04130	COG1580	Controls the rotational direction of flagella during chemotaxis
BBB50_RS04155	COG1987	bacterial-type flagellum assembly
BBB50_RS04160	COG1684	flagellar biosynthetic protein fliR
BBB50_RS04170	COG2840	Smr protein MutS2
BBB50_RS04175	COG2890	protein-(glutamine-N5) methyltransferase activity
BBB50_RS04185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BBB50_RS04190	COG2860	membrane
BBB50_RS04195	COG3101	peptidyl-lysine hydroxylation
BBB50_RS04205	COG0431	NADPH-dependent FMN reductase
BBB50_RS04215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBB50_RS04220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBB50_RS04225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBB50_RS04230	COG0735	belongs to the Fur family
BBB50_RS04240	COG0583	DNA-binding transcription factor activity
BBB50_RS04250	COG1346	cytolysis
BBB50_RS04265	COG0596	Alpha beta hydrolase
BBB50_RS04270	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BBB50_RS04275	COG0033	Phosphoglucomutase
BBB50_RS04285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBB50_RS04290	COG0372	Belongs to the citrate synthase family
BBB50_RS04295	COG2009	succinate dehydrogenase
BBB50_RS04300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BBB50_RS04305	COG1053	succinate dehydrogenase
BBB50_RS04315	COG0567	Dehydrogenase, E1 component
BBB50_RS04320	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBB50_RS04325	COG0045	succinate-CoA ligase (ADP-forming) activity
BBB50_RS04335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBB50_RS04340	COG1121	(ABC) transporter
BBB50_RS04345	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BBB50_RS04350	COG4977	sequence-specific DNA binding
BBB50_RS04355	COG1918	ferrous iron import across plasma membrane
BBB50_RS04375	COG0018	arginyl-trna synthetase
BBB50_RS04385	COG1025	Belongs to the peptidase M16 family
BBB50_RS04390	COG2062	phosphohistidine phosphatase, SixA
BBB50_RS04420	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BBB50_RS04425	COG2198	Histidine kinase
BBB50_RS04425	COG0643	Histidine kinase
BBB50_RS04425	COG0784	Response regulator, receiver
BBB50_RS04430	COG2201	protein-glutamate methylesterase activity
BBB50_RS04435	COG1192	Involved in chromosome partitioning
BBB50_RS04445	COG0835	chemotaxis
BBB50_RS04455	COG4133	protoheme IX ABC transporter activity
BBB50_RS04460	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBB50_RS04465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBB50_RS04475	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BBB50_RS04480	COG1138	Cytochrome C-type biogenesis protein
BBB50_RS04485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBB50_RS04500	COG2853	Lipoprotein
BBB50_RS04520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BBB50_RS04525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBB50_RS04530	COG0123	including yeast histone deacetylase and acetoin utilization protein
BBB50_RS04545	COG3083	sulfuric ester hydrolase activity
BBB50_RS04550	COG3082	Protein of unknown function (DUF1414)
BBB50_RS04555	COG3081	Nucleoid-associated protein
BBB50_RS04565	COG1757	Na H antiporter
BBB50_RS04570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBB50_RS04575	COG2095	MarC family integral membrane protein
BBB50_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS04580	COG1454	alcohol dehydrogenase
BBB50_RS04590	COG0659	secondary active sulfate transmembrane transporter activity
BBB50_RS04595	COG1530	ribonuclease E activity
BBB50_RS04610	COG0564	pseudouridine synthase activity
BBB50_RS04615	COG0424	maF-like protein
BBB50_RS04620	COG1399	metal-binding, possibly nucleic acid-binding protein
BBB50_RS04625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BBB50_RS04630	COG0416	fatty acid biosynthetic process
BBB50_RS04635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BBB50_RS04645	COG1028	Short-chain dehydrogenase reductase Sdr
BBB50_RS04650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBB50_RS04655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBB50_RS04660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBB50_RS04665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BBB50_RS04670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BBB50_RS04680	COG0084	hydrolase, TatD family'
BBB50_RS04685	COG1263	PTS System
BBB50_RS04685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_RS04690	COG0733	neurotransmitter:sodium symporter activity
BBB50_RS04700	COG4667	esterase of the alpha-beta hydrolase superfamily
BBB50_RS04710	COG1940	carbohydrate kinase activity
BBB50_RS04715	COG0835	chemotaxis
BBB50_RS04715	COG0784	Response regulator, receiver
BBB50_RS04730	COG2226	methyltransferase
BBB50_RS04740	COG0676	glucose-6-phosphate 1-epimerase activity
BBB50_RS04745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBB50_RS04750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_RS04760	COG3139	Protein of unknown function (DUF1315)
BBB50_RS04765	COG0252	asparaginase activity
BBB50_RS04770	COG0616	signal peptide processing
BBB50_RS04775	COG0446	pyridine nucleotide-disulphide oxidoreductase
BBB50_RS04775	COG1902	pentaerythritol trinitrate reductase activity
BBB50_RS04780	COG0788	formyltetrahydrofolate deformylase activity
BBB50_RS04790	COG1199	ATP-dependent helicase activity
BBB50_RS04795	COG1214	PFAM Peptidase M22, glycoprotease
BBB50_RS04810	COG0596	Alpha beta hydrolase
BBB50_RS04815	COG0318	PFAM AMP-dependent synthetase and ligase
BBB50_RS04820	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BBB50_RS04840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BBB50_RS04845	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BBB50_RS04850	COG0436	Aminotransferase
BBB50_RS04855	COG1169	isochorismate synthase
BBB50_RS04860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BBB50_RS04865	COG0596	Alpha beta hydrolase
BBB50_RS04885	COG3135	benzoate transporter
BBB50_RS04890	COG1396	sequence-specific DNA binding
BBB50_RS04895	COG0840	transmembrane signaling receptor activity
BBB50_RS04905	COG0477	Major facilitator Superfamily
BBB50_RS04925	COG3015	lipoprotein NlpE involved in copper resistance
BBB50_RS04930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BBB50_RS04935	COG2894	cell division
BBB50_RS04940	COG0850	regulation of cytokinetic process
BBB50_RS04945	COG3100	YcgL domain-containing protein
BBB50_RS04950	COG2951	lytic endotransglycosylase activity
BBB50_RS04960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BBB50_RS04965	COG3469	chitinase activity
BBB50_RS04965	COG3325	Belongs to the glycosyl hydrolase 18 family
BBB50_RS04970	COG3005	denitrification pathway
BBB50_RS04975	COG0243	molybdopterin cofactor binding
BBB50_RS04990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_RS05005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BBB50_RS05040	COG4589	Belongs to the CDS family
BBB50_RS05050	COG3300	MHYT domain
BBB50_RS05050	COG5001	Diguanylate cyclase
BBB50_RS05065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BBB50_RS05070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BBB50_RS05075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBB50_RS05080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBB50_RS05090	COG4191	Histidine kinase
BBB50_RS05100	COG0544	peptidyl-prolyl cis-trans isomerase activity
BBB50_RS05110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BBB50_RS05115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BBB50_RS05120	COG0776	regulation of translation
BBB50_RS05125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBB50_RS05130	COG1555	photosystem II stabilization
BBB50_RS05135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BBB50_RS05140	COG0539	negative regulation of cytoplasmic translation
BBB50_RS05145	COG0776	regulation of translation
BBB50_RS05150	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BBB50_RS05155	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BBB50_RS05175	COG0583	DNA-binding transcription factor activity
BBB50_RS05185	COG0686	Belongs to the AlaDH PNT family
BBB50_RS05195	COG1674	ftsk spoiiie
BBB50_RS05200	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BBB50_RS05205	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBB50_RS05210	COG2186	Transcriptional regulator
BBB50_RS05225	COG0537	adenosine 5'-monophosphoramidase activity
BBB50_RS05250	COG3150	esterase
BBB50_RS05255	COG1252	NADH dehydrogenase
BBB50_RS05275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BBB50_RS05285	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBB50_RS05290	COG1136	(ABC) transporter
BBB50_RS05295	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBB50_RS05305	COG0658	competence protein
BBB50_RS05305	COG2333	competence protein COMEC
BBB50_RS05310	COG1132	(ABC) transporter
BBB50_RS05315	COG1663	tetraacyldisaccharide 4'-kinase activity
BBB50_RS05320	COG2835	tetraacyldisaccharide 4'-kinase activity
BBB50_RS05325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BBB50_RS05330	COG2719	SpoVR family
BBB50_RS05335	COG2718	Belongs to the UPF0229 family
BBB50_RS05340	COG2766	serine protein kinase
BBB50_RS05345	COG3013	Belongs to the UPF0304 family
BBB50_RS05355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BBB50_RS05360	COG0840	transmembrane signaling receptor activity
BBB50_RS05370	COG1882	Formate acetyltransferase
BBB50_RS05395	COG4160	amino acid transport
BBB50_RS05400	COG0708	Exodeoxyribonuclease III
BBB50_RS05405	COG0840	transmembrane signaling receptor activity
BBB50_RS05415	COG3923	Primosomal replication protein n
BBB50_RS05420	COG0730	response to heat
BBB50_RS05425	COG1199	ATP-dependent helicase activity
BBB50_RS05430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BBB50_RS05435	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
BBB50_RS05440	COG3012	SEC-C Motif Domain Protein
BBB50_RS05445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BBB50_RS05450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BBB50_RS05455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBB50_RS05460	COG0215	cysteine-tRNA ligase activity
BBB50_RS05465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BBB50_RS05470	COG0632	four-way junction helicase activity
BBB50_RS05480	COG1271	oxidase subunit
BBB50_RS05485	COG1294	oxidase, subunit
BBB50_RS05490	COG4890	Cyd operon protein YbgT
BBB50_RS05495	COG3790	cyd operon protein YbgE
BBB50_RS05500	COG0824	Thioesterase
BBB50_RS05505	COG0811	peptide transport
BBB50_RS05520	COG0823	Involved in the tonB-independent uptake of proteins
BBB50_RS05525	COG2885	chlorophyll binding
BBB50_RS05535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BBB50_RS05545	COG0784	Response regulator, receiver
BBB50_RS05545	COG5002	protein histidine kinase activity
BBB50_RS05555	COG1482	cell wall glycoprotein biosynthetic process
BBB50_RS05560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_RS05560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_RS05560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_RS05565	COG2207	Transcriptional regulator
BBB50_RS05575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_RS05580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_RS05585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBB50_RS05595	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS05600	COG3284	Transcriptional regulator
BBB50_RS05605	COG4628	conserved protein (DUF2132)
BBB50_RS05615	COG0415	Belongs to the DNA photolyase family
BBB50_RS05685	COG0488	(ABC) transporter
BBB50_RS05725	COG3941	tape measure
BBB50_RS05745	COG2003	Belongs to the UPF0758 family
BBB50_RS05755	COG4409	exo-alpha-(2->6)-sialidase activity
BBB50_RS05760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BBB50_RS05765	COG1940	carbohydrate kinase activity
BBB50_RS05780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BBB50_RS05785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBB50_RS05790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBB50_RS05795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBB50_RS05800	COG1737	Transcriptional regulator
BBB50_RS05805	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BBB50_RS05810	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BBB50_RS05830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BBB50_RS05850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BBB50_RS05870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBB50_RS05880	COG0582	viral genome integration into host DNA
BBB50_RS05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_RS05905	COG3008	intermembrane lipid transfer
BBB50_RS05905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BBB50_RS05910	COG2995	paraquat-inducible protein a
BBB50_RS05915	COG0668	transmembrane transport
BBB50_RS05940	COG1309	transcriptional regulator
BBB50_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS05970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBB50_RS05975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BBB50_RS06005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBB50_RS06010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BBB50_RS06015	COG0297	glycogen (starch) synthase activity
BBB50_RS06035	COG3070	regulator of competence-specific genes
BBB50_RS06040	COG1609	Transcriptional regulator
BBB50_RS06050	COG0745	RESPONSE REGULATOR receiver
BBB50_RS06055	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BBB50_RS06060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBB50_RS06070	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BBB50_RS06090	COG1032	radical SAM domain protein
BBB50_RS06095	COG5001	Diguanylate cyclase
BBB50_RS06100	COG0612	Peptidase, M16
BBB50_RS06115	COG0583	DNA-binding transcription factor activity
BBB50_RS06120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BBB50_RS06130	COG2350	Protein conserved in bacteria
BBB50_RS06135	COG1607	acyl-coa hydrolase
BBB50_RS06150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BBB50_RS06155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBB50_RS06165	COG2116	formate transmembrane transporter activity
BBB50_RS06175	COG4459	periplasmic nitrate reductase
BBB50_RS06180	COG3005	denitrification pathway
BBB50_RS06185	COG0243	molybdopterin cofactor binding
BBB50_RS06205	COG1227	inorganic diphosphatase activity
BBB50_RS06220	COG4172	Belongs to the ABC transporter superfamily
BBB50_RS06235	COG4168	peptide transport system, permease
BBB50_RS06245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BBB50_RS06250	COG1842	Phage shock protein A
BBB50_RS06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_RS06280	COG2818	Glycosylase
BBB50_RS06285	COG0626	cystathionine gamma-synthase activity
BBB50_RS06295	COG0733	neurotransmitter:sodium symporter activity
BBB50_RS06300	COG0564	pseudouridine synthase activity
BBB50_RS06305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBB50_RS06310	COG4136	ATPase activity
BBB50_RS06315	COG4135	transport system, permease component
BBB50_RS06320	COG4134	Bacterial extracellular solute-binding protein
BBB50_RS06330	COG3313	Fe-S protein
BBB50_RS06340	COG0842	Transport permease protein
BBB50_RS06345	COG1131	(ABC) transporter
BBB50_RS06350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_RS06355	COG0814	amino acid
BBB50_RS06365	COG2239	Acts as a magnesium transporter
BBB50_RS06370	COG2205	protein histidine kinase activity
BBB50_RS06370	COG0784	Response regulator, receiver
BBB50_RS06385	COG4934	collagen metabolic process
BBB50_RS06415	COG0840	transmembrane signaling receptor activity
BBB50_RS06430	COG2203	Gaf domain
BBB50_RS06430	COG5001	Diguanylate cyclase
BBB50_RS06430	COG4251	negative regulation of phosphorylation
BBB50_RS06430	COG3706	GGDEF domain
BBB50_RS06435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BBB50_RS06455	COG1061	Type III restriction enzyme res subunit
BBB50_RS06460	COG1187	pseudouridine synthase activity
BBB50_RS06465	COG2814	Major facilitator Superfamily
BBB50_RS06475	COG0702	epimerase
BBB50_RS06480	COG0534	Mate efflux family protein
BBB50_RS06485	COG4181	ATPase activity
BBB50_RS06490	COG0577	efflux transmembrane transporter activity
BBB50_RS06500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BBB50_RS06510	COG1748	Saccharopine dehydrogenase
BBB50_RS06525	COG1538	Outer membrane efflux protein
BBB50_RS06550	COG0583	DNA-binding transcription factor activity
BBB50_RS06560	COG1451	nucleotide metabolic process
BBB50_RS06575	COG3063	Type IV pilus biogenesis stability protein PilW
BBB50_RS06580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BBB50_RS06600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_RS06615	COG3290	protein histidine kinase activity
BBB50_RS06620	COG4565	transcriptional regulatory protein
BBB50_RS06630	COG0835	chemotaxis
BBB50_RS06630	COG0784	Response regulator, receiver
BBB50_RS06670	COG1085	galactose-1-phosphate uridylyltransferase
BBB50_RS06675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBB50_RS06680	COG2017	converts alpha-aldose to the beta-anomer
BBB50_RS06690	COG2199	diguanylate cyclase activity
BBB50_RS06690	COG2200	EAL domain
BBB50_RS06705	COG3527	Alpha-acetolactate decarboxylase
BBB50_RS06720	COG0753	catalase activity
BBB50_RS06740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBB50_RS06750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBB50_RS06790	COG1271	oxidase subunit
BBB50_RS06795	COG1294	oxidase, subunit
BBB50_RS06800	COG1136	(ABC) transporter
BBB50_RS06800	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBB50_RS06805	COG0577	efflux transmembrane transporter activity
BBB50_RS06805	COG1136	(ABC) transporter
BBB50_RS06810	COG1136	(ABC) transporter
BBB50_RS06810	COG0577	efflux transmembrane transporter activity
BBB50_RS06830	COG0583	DNA-binding transcription factor activity
BBB50_RS06840	COG2723	6-phospho-beta-galactosidase activity
BBB50_RS06845	COG1609	Transcriptional regulator
BBB50_RS06850	COG0251	oxidation-reduction process
BBB50_RS06855	COG2731	YhcH YjgK YiaL family protein
BBB50_RS06860	COG0584	glycerophosphoryl diester phosphodiesterase
BBB50_RS06865	COG1349	DNA-binding transcription factor activity
BBB50_RS06870	COG3842	ATPase activity
BBB50_RS06875	COG0395	ABC-type sugar transport system, permease component
BBB50_RS06880	COG1175	transmembrane transport
BBB50_RS06895	COG0811	peptide transport
BBB50_RS06900	COG0811	peptide transport
BBB50_RS06905	COG0848	biopolymer transport protein
BBB50_RS06910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BBB50_RS06920	COG1793	dna ligase
BBB50_RS06930	COG0534	Mate efflux family protein
BBB50_RS06940	COG3001	Fructosamine kinase
BBB50_RS06950	COG0791	NLP P60 protein
BBB50_RS06955	COG0840	transmembrane signaling receptor activity
BBB50_RS06965	COG3148	PFAM DTW domain containing protein
BBB50_RS06970	COG1940	carbohydrate kinase activity
BBB50_RS07000	COG0746	molybdenum cofactor guanylyltransferase activity
BBB50_RS07005	COG3842	ATPase activity
BBB50_RS07010	COG4662	Binding-protein-dependent transport system inner membrane component
BBB50_RS07020	COG2204	response regulator
BBB50_RS07025	COG3852	Histidine kinase
BBB50_RS07030	COG0488	(ABC) transporter
BBB50_RS07035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BBB50_RS07065	COG3383	formate dehydrogenase (NAD+) activity
BBB50_RS07065	COG0243	molybdopterin cofactor binding
BBB50_RS07070	COG0437	4 iron, 4 sulfur cluster binding
BBB50_RS07085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBB50_RS07090	COG1666	GTP binding
BBB50_RS07095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBB50_RS07110	COG2996	Protein conserved in bacteria
BBB50_RS07120	COG3008	intermembrane lipid transfer
BBB50_RS07125	COG2995	paraquat-inducible protein a
BBB50_RS07130	COG1132	(ABC) transporter
BBB50_RS07135	COG1956	GAF domain-containing protein
BBB50_RS07140	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BBB50_RS07155	COG0308	aminopeptidase N
BBB50_RS07170	COG0167	dihydroorotate dehydrogenase activity
BBB50_RS07180	COG0116	Belongs to the methyltransferase superfamily
BBB50_RS07180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BBB50_RS07190	COG0488	(ABC) transporter
BBB50_RS07205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BBB50_RS07210	COG1067	ATP-dependent peptidase activity
BBB50_RS07215	COG3120	sequence-specific DNA binding
BBB50_RS07300	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BBB50_RS07300	COG3064	Membrane
BBB50_RS07300	COG1073	alpha beta
BBB50_RS07305	COG2994	toxin metabolic process
BBB50_RS07330	COG0784	Response regulator, receiver
BBB50_RS07330	COG2205	protein histidine kinase activity
BBB50_RS07345	COG3278	Belongs to the heme-copper respiratory oxidase family
BBB50_RS07360	COG2010	Cytochrome c
BBB50_RS07370	COG2217	Heavy metal translocating P-type atpase
BBB50_RS07385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBB50_RS07390	COG0589	response to stress
BBB50_RS07435	COG0017	Asparaginyl-tRNA synthetase
BBB50_RS07440	COG0351	phosphomethylpyrimidine kinase
BBB50_RS07445	COG3437	response regulator, receiver
BBB50_RS07445	COG2770	Histidine kinase
BBB50_RS07455	COG1448	Aminotransferase
BBB50_RS07470	COG0840	transmembrane signaling receptor activity
BBB50_RS07475	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BBB50_RS07485	COG3278	Belongs to the heme-copper respiratory oxidase family
BBB50_RS07500	COG2010	Cytochrome c
BBB50_RS07510	COG2217	Heavy metal translocating P-type atpase
BBB50_RS07525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBB50_RS07530	COG0589	response to stress
BBB50_RS07555	COG3842	ATPase activity
BBB50_RS07565	COG1177	transmembrane transport
BBB50_RS07575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBB50_RS07590	COG1115	amino acid carrier protein
BBB50_RS07595	COG1280	lysine exporter protein (LysE YggA)
BBB50_RS07610	COG3675	Pfam Lipase (class 3)
BBB50_RS07630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BBB50_RS07640	COG2814	Major facilitator Superfamily
BBB50_RS07645	COG1566	PFAM secretion protein HlyD family protein
BBB50_RS07650	COG1538	Outer membrane efflux protein
BBB50_RS07660	COG0513	Belongs to the DEAD box helicase family
BBB50_RS07670	COG0840	transmembrane signaling receptor activity
BBB50_RS07675	COG0840	transmembrane signaling receptor activity
BBB50_RS07675	COG3290	protein histidine kinase activity
BBB50_RS07680	COG0835	chemotaxis
BBB50_RS07685	COG2201	protein-glutamate methylesterase activity
BBB50_RS07695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BBB50_RS07700	COG0643	Histidine kinase
BBB50_RS07700	COG0784	Response regulator, receiver
BBB50_RS07700	COG2198	Histidine kinase
BBB50_RS07705	COG2198	Histidine kinase
BBB50_RS07705	COG0643	Histidine kinase
BBB50_RS07715	COG0745	RESPONSE REGULATOR receiver
BBB50_RS07730	COG0415	Belongs to the DNA photolyase family
BBB50_RS07735	COG0477	Major facilitator Superfamily
BBB50_RS07740	COG0583	DNA-binding transcription factor activity
BBB50_RS07750	COG0095	Lipoate-protein ligase
BBB50_RS07755	COG0443	Heat shock 70 kDa protein
BBB50_RS07765	COG1643	Atp-dependent helicase
BBB50_RS07805	COG0443	Heat shock 70 kDa protein
BBB50_RS07810	COG0443	Heat shock 70 kDa protein
BBB50_RS07815	COG3706	GGDEF domain
BBB50_RS07845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BBB50_RS07850	COG0602	queuosine metabolic process
BBB50_RS07855	COG0561	phosphatase activity
BBB50_RS07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB50_RS07870	COG4597	amino acid ABC transporter
BBB50_RS07875	COG0765	amino acid transport
BBB50_RS07880	COG1126	abc transporter atp-binding protein
BBB50_RS07885	COG0670	Belongs to the BI1 family
BBB50_RS07890	COG2920	part of a sulfur-relay system
BBB50_RS07895	COG1254	Belongs to the acylphosphatase family
BBB50_RS07900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BBB50_RS07905	COG3706	GGDEF domain
BBB50_RS07920	COG2205	protein histidine kinase activity
BBB50_RS07920	COG3437	response regulator, receiver
BBB50_RS07920	COG3850	Histidine kinase
BBB50_RS07920	COG4999	Histidine kinase
BBB50_RS07925	COG3437	response regulator, receiver
BBB50_RS07930	COG0625	glutathione transferase activity
BBB50_RS07940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BBB50_RS07950	COG2195	Cleaves the N-terminal amino acid of tripeptides
BBB50_RS07980	COG0372	Belongs to the citrate synthase family
BBB50_RS07985	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BBB50_RS08025	COG1129	ABC transporter
BBB50_RS08060	COG0745	RESPONSE REGULATOR receiver
BBB50_RS08065	COG2205	protein histidine kinase activity
BBB50_RS08070	COG3713	MltA-interacting MipA family protein
BBB50_RS08075	COG2990	Protein conserved in bacteria
BBB50_RS08085	COG4191	Histidine kinase
BBB50_RS08085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBB50_RS08090	COG0471	metal ion transport
BBB50_RS08100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBB50_RS08115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBB50_RS08125	COG3768	UPF0283 membrane protein
BBB50_RS08130	COG3106	COG3106 Predicted ATPase
BBB50_RS08145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBB50_RS08150	COG0494	nUDIX hydrolase
BBB50_RS08155	COG0814	amino acid
BBB50_RS08160	COG1760	l-serine dehydratase
BBB50_RS08165	COG0720	synthase
BBB50_RS08170	COG0840	transmembrane signaling receptor activity
BBB50_RS08175	COG0017	Asparaginyl-tRNA synthetase
BBB50_RS08180	COG0351	phosphomethylpyrimidine kinase
BBB50_RS08185	COG3437	response regulator, receiver
BBB50_RS08185	COG2770	Histidine kinase
BBB50_RS08195	COG1448	Aminotransferase
BBB50_RS08210	COG0840	transmembrane signaling receptor activity
BBB50_RS08215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BBB50_RS08220	COG2943	transferase activity, transferring hexosyl groups
BBB50_RS08225	COG1609	Transcriptional regulator
BBB50_RS08235	COG1486	melibiose metabolic process
BBB50_RS08240	COG1447	Phosphotransferase system cellobiose-specific component IIA
BBB50_RS08250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BBB50_RS08255	COG0726	polysaccharide deacetylase
BBB50_RS08260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BBB50_RS08265	COG1846	Transcriptional regulator
BBB50_RS08290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BBB50_RS08305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBB50_RS08310	COG3108	Peptidase M15
BBB50_RS08315	COG2989	Protein conserved in bacteria
BBB50_RS08340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBB50_RS08350	COG2814	Major facilitator Superfamily
BBB50_RS08360	COG1054	Belongs to the UPF0176 family
BBB50_RS08370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BBB50_RS08375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBB50_RS08380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBB50_RS08425	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BBB50_RS08430	COG4139	cobalamin transport
BBB50_RS08450	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BBB50_RS08455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BBB50_RS08460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBB50_RS08465	COG1823	symporter activity
BBB50_RS08470	COG2925	Exonuclease
BBB50_RS08475	COG1380	Effector of murein hydrolase LrgA
BBB50_RS08480	COG1346	cytolysis
BBB50_RS08520	COG0776	regulation of translation
BBB50_RS08525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_RS08525	COG0072	phenylalanine-tRNA ligase activity
BBB50_RS08530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BBB50_RS08570	COG0322	excinuclease ABC activity
BBB50_RS08575	COG2197	response regulator
BBB50_RS08580	COG0417	DNA replication proofreading
BBB50_RS08585	COG5001	Diguanylate cyclase
BBB50_RS08595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BBB50_RS08600	COG3099	Belongs to the UPF0263 family
BBB50_RS08615	COG1228	amidohydrolase
BBB50_RS08620	COG0010	Belongs to the arginase family
BBB50_RS08625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BBB50_RS08630	COG2986	histidine ammonia-lyase
BBB50_RS08650	COG0247	lactate metabolic process
BBB50_RS08650	COG0277	FAD linked oxidase domain protein
BBB50_RS08665	COG2885	chlorophyll binding
BBB50_RS08685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BBB50_RS08695	COG0281	malic enzyme
BBB50_RS08705	COG2949	membrane
BBB50_RS08710	COG3706	GGDEF domain
BBB50_RS08715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBB50_RS08725	COG0492	ferredoxin-NADP+ reductase activity
BBB50_RS08730	COG4988	ABC transporter
BBB50_RS08735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BBB50_RS08740	COG1187	pseudouridine synthase activity
BBB50_RS08745	COG0009	L-threonylcarbamoyladenylate synthase
BBB50_RS08750	COG0613	PHP domain protein
BBB50_RS08760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBB50_RS08765	COG0512	Glutamine amidotransferase of anthranilate synthase
BBB50_RS08770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBB50_RS08775	COG0135	phosphoribosylanthranilate isomerase activity
BBB50_RS08775	COG0134	indole-3-glycerol-phosphate synthase activity
BBB50_RS08780	COG0133	tryptophan synthase activity
BBB50_RS08785	COG0159	tryptophan synthase activity
BBB50_RS08795	COG1435	thymidine kinase activity
BBB50_RS08800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BBB50_RS08805	COG1801	Protein of unknown function DUF72
BBB50_RS08810	COG4106	trans-aconitate 2-methyltransferase activity
BBB50_RS08815	COG0500	methyltransferase
BBB50_RS08820	COG4067	protein conserved in archaea
BBB50_RS08820	COG0189	ligase activity
BBB50_RS08835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BBB50_RS08845	COG3852	Histidine kinase
BBB50_RS08860	COG3070	regulator of competence-specific genes
BBB50_RS08870	COG2431	L-lysine efflux transmembrane transporter activity
BBB50_RS08880	COG0076	glutamate decarboxylase activity
BBB50_RS08885	COG1737	Transcriptional regulator
BBB50_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS08890	COG1454	alcohol dehydrogenase
BBB50_RS08895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBB50_RS08900	COG3273	potassium ion transport
BBB50_RS08900	COG2985	domain, Protein
BBB50_RS08905	COG0542	response to heat
BBB50_RS08910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BBB50_RS08915	COG1278	Cold shock
BBB50_RS08925	COG1187	pseudouridine synthase activity
BBB50_RS08930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BBB50_RS08930	COG0140	phosphoribosyl-ATP diphosphatase activity
BBB50_RS08935	COG0107	imidazoleglycerol-phosphate synthase activity
BBB50_RS08940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BBB50_RS08945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BBB50_RS08950	COG0131	Imidazoleglycerol-phosphate dehydratase
BBB50_RS08950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BBB50_RS08955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBB50_RS08960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BBB50_RS08965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BBB50_RS08970	COG1757	Na H antiporter
BBB50_RS08975	COG2916	Histone family protein nucleoid-structuring protein H-NS
BBB50_RS08980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBB50_RS08985	COG0482	sulfurtransferase activity
BBB50_RS08990	COG2915	High frequency lysogenization protein hflD homolog
BBB50_RS08995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBB50_RS09005	COG2268	Band 7 protein
BBB50_RS09015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BBB50_RS09030	COG0300	oxidoreductase activity
BBB50_RS09040	COG0501	Belongs to the peptidase M48B family
BBB50_RS09050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BBB50_RS09055	COG2226	methyltransferase
BBB50_RS09060	COG0156	8-amino-7-oxononanoate synthase activity
BBB50_RS09065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BBB50_RS09070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BBB50_RS09075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BBB50_RS09080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BBB50_RS09085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BBB50_RS09095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBB50_RS09100	COG2199	diguanylate cyclase activity
BBB50_RS09100	COG2203	Gaf domain
BBB50_RS09110	COG4120	Belongs to the binding-protein-dependent transport system permease family
BBB50_RS09120	COG4628	conserved protein (DUF2132)
BBB50_RS09125	COG3092	negative regulation of chromosome organization
BBB50_RS09130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBB50_RS09135	COG0857	belongs to the CobB CobQ family
BBB50_RS09135	COG0280	phosphate acetyltransferase
BBB50_RS09140	COG0435	Glutathione S-transferase
BBB50_RS09145	COG4608	Belongs to the ABC transporter superfamily
BBB50_RS09150	COG0444	Belongs to the ABC transporter superfamily
BBB50_RS09155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB50_RS09160	COG0601	transmembrane transport
BBB50_RS09180	COG2204	response regulator
BBB50_RS09185	COG5001	Diguanylate cyclase
BBB50_RS09185	COG3300	MHYT domain
BBB50_RS09190	COG4191	Histidine kinase
BBB50_RS09195	COG5002	protein histidine kinase activity
BBB50_RS09205	COG2201	protein-glutamate methylesterase activity
BBB50_RS09220	COG0009	L-threonylcarbamoyladenylate synthase
BBB50_RS09240	COG1881	PFAM PEBP family protein
BBB50_RS09265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBB50_RS09270	COG0640	Transcriptional regulator
BBB50_RS09280	COG3706	GGDEF domain
BBB50_RS09300	COG1946	Acyl-CoA thioesterase
BBB50_RS09305	COG1522	sequence-specific DNA binding
BBB50_RS09315	COG0616	signal peptide processing
BBB50_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
BBB50_RS09325	COG2983	Belongs to the UPF0260 family
BBB50_RS09335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BBB50_RS09340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BBB50_RS09350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BBB50_RS09355	COG2832	Protein of unknown function (DUF454)
BBB50_RS09365	COG0745	RESPONSE REGULATOR receiver
BBB50_RS09370	COG0583	DNA-binding transcription factor activity
BBB50_RS09375	COG0778	Nitroreductase
BBB50_RS09380	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBB50_RS09380	COG1024	Enoyl-CoA hydratase
BBB50_RS09385	COG0183	Belongs to the thiolase family
BBB50_RS09400	COG2067	long-chain fatty acid transport protein
BBB50_RS09410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBB50_RS09415	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BBB50_RS09420	COG2982	Protein involved in outer membrane biogenesis
BBB50_RS09425	COG0572	uridine kinase
BBB50_RS09435	COG0489	protein tyrosine kinase activity
BBB50_RS09440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_RS09440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBB50_RS09450	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BBB50_RS09465	COG0517	IMP dehydrogenase activity
BBB50_RS09465	COG0617	tRNA 3'-terminal CCA addition
BBB50_RS09465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BBB50_RS09470	COG2199	diguanylate cyclase activity
BBB50_RS09475	COG0314	molybdopterin synthase activity
BBB50_RS09480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BBB50_RS09485	COG0315	cyclic pyranopterin monophosphate synthase activity
BBB50_RS09490	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBB50_RS09495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BBB50_RS09500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BBB50_RS09505	COG2198	Histidine kinase
BBB50_RS09510	COG2204	response regulator
BBB50_RS09520	COG0556	nucleotide-excision repair
BBB50_RS09530	COG4657	Part of a membrane complex involved in electron transport
BBB50_RS09535	COG2878	Part of a membrane complex involved in electron transport
BBB50_RS09540	COG4656	Part of a membrane complex involved in electron transport
BBB50_RS09560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BBB50_RS09565	COG0346	lactoylglutathione lyase activity
BBB50_RS09585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBB50_RS09590	COG2056	Na+-H+ antiporter family
BBB50_RS09595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BBB50_RS09600	COG1286	toxin biosynthetic process
BBB50_RS09605	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BBB50_RS09610	COG0285	dihydrofolate synthase activity
BBB50_RS09615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BBB50_RS09620	COG0101	tRNA pseudouridine synthase activity
BBB50_RS09635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_RS09635	COG1263	PTS System
BBB50_RS09635	COG2190	(PTS) system
BBB50_RS09640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BBB50_RS09645	COG1846	Transcriptional regulator
BBB50_RS09645	COG1940	carbohydrate kinase activity
BBB50_RS09650	COG4651	solute:proton antiporter activity
BBB50_RS09650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBB50_RS09655	COG0367	asparagine synthase
BBB50_RS09670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BBB50_RS09675	COG0563	adenylate kinase activity
BBB50_RS09680	COG0326	Molecular chaperone. Has ATPase activity
BBB50_RS09685	COG3710	Transcriptional regulator
BBB50_RS09700	COG0622	Phosphoesterase
BBB50_RS09705	COG1090	epimerase
BBB50_RS09710	COG0300	oxidoreductase activity
BBB50_RS09715	COG3118	belongs to the thioredoxin family
BBB50_RS09720	COG0330	HflC and HflK could
BBB50_RS09725	COG1585	Membrane protein implicated in regulation of membrane protease activity
BBB50_RS09730	COG0789	Transcriptional regulator
BBB50_RS09745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BBB50_RS09750	COG3115	cell septum assembly
BBB50_RS09755	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BBB50_RS09760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBB50_RS09770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBB50_RS09780	COG2190	(PTS) system
BBB50_RS09785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BBB50_RS09790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBB50_RS09795	COG1702	phosphate starvation-inducible protein PhoH
BBB50_RS09805	COG4535	Mg2 and Co2 transporter CorC
BBB50_RS09810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BBB50_RS09815	COG2888	peptidyl-tyrosine sulfation
BBB50_RS09820	COG0495	leucyl-tRNA aminoacylation
BBB50_RS09825	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BBB50_RS09830	COG1466	dna polymerase III delta subunit
BBB50_RS09835	COG0799	negative regulation of ribosome biogenesis
BBB50_RS09840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BBB50_RS09845	COG0768	penicillin binding
BBB50_RS09850	COG0772	Belongs to the SEDS family
BBB50_RS09855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BBB50_RS09860	COG1686	Belongs to the peptidase S11 family
BBB50_RS09865	COG2921	Belongs to the UPF0250 family
BBB50_RS09870	COG0321	lipoyl(octanoyl) transferase activity
BBB50_RS09875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BBB50_RS09885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BBB50_RS09910	COG1596	polysaccharide export
BBB50_RS09920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBB50_RS09950	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BBB50_RS09960	COG0438	transferase activity, transferring glycosyl groups
BBB50_RS09970	COG1045	serine acetyltransferase
BBB50_RS09990	COG0110	maltose O-acetyltransferase activity
BBB50_RS09995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BBB50_RS10000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BBB50_RS10005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBB50_RS10010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBB50_RS10040	COG0366	Alpha amylase catalytic
BBB50_RS10045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_RS10045	COG1263	PTS System
BBB50_RS10050	COG1609	Transcriptional regulator
BBB50_RS10055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BBB50_RS10060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBB50_RS10065	COG2011	ABC-type metal ion transport system permease component
BBB50_RS10070	COG1464	Belongs to the NlpA lipoprotein family
BBB50_RS10075	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BBB50_RS10085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BBB50_RS10085	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BBB50_RS10100	COG1611	Belongs to the LOG family
BBB50_RS10105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBB50_RS10110	COG2363	Small membrane protein
BBB50_RS10115	COG0583	DNA-binding transcription factor activity
BBB50_RS10125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBB50_RS10125	COG0301	tRNA thio-modification
BBB50_RS10135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BBB50_RS10140	COG1722	exodeoxyribonuclease VII activity
BBB50_RS10145	COG0142	geranyltranstransferase activity
BBB50_RS10150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBB50_RS10155	COG0564	pseudouridine synthase activity
BBB50_RS10160	COG3098	single-species biofilm formation
BBB50_RS10175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BBB50_RS10185	COG1671	Belongs to the UPF0178 family
BBB50_RS10190	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BBB50_RS10195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBB50_RS10200	COG0254	rRNA binding
BBB50_RS10205	COG1720	tRNA m6t6A37 methyltransferase activity
BBB50_RS10210	COG0442	prolyl-tRNA aminoacylation
BBB50_RS10240	COG0047	phosphoribosylformylglycinamidine synthase activity
BBB50_RS10240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BBB50_RS10250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BBB50_RS10265	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BBB50_RS10300	COG0484	heat shock protein binding
BBB50_RS10305	COG0443	Heat shock 70 kDa protein
BBB50_RS10310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BBB50_RS10315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BBB50_RS10320	COG0497	DNA recombination
BBB50_RS10325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBB50_RS10330	COG2914	Belongs to the UPF0125 (RnfH) family
BBB50_RS10335	COG2867	negative regulation of translational initiation
BBB50_RS10340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BBB50_RS10350	COG0582	viral genome integration into host DNA
BBB50_RS10360	COG3064	Membrane
BBB50_RS10370	COG0739	heme binding
BBB50_RS10390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BBB50_RS10395	COG2207	Transcriptional regulator
BBB50_RS10405	COG1459	type II secretion system
BBB50_RS10410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_RS10430	COG4796	Type ii and iii secretion system protein
BBB50_RS10445	COG2165	general secretion pathway protein
BBB50_RS10455	COG3710	Transcriptional regulator
BBB50_RS10460	COG0840	transmembrane signaling receptor activity
BBB50_RS10465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BBB50_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS10555	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BBB50_RS10560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BBB50_RS10565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBB50_RS10585	COG3051	citrate lyase alpha subunit
BBB50_RS10590	COG2301	Belongs to the HpcH HpaI aldolase family
BBB50_RS10600	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BBB50_RS10610	COG3630	sodium ion export across plasma membrane
BBB50_RS10615	COG0511	ligase activity, forming carbon-carbon bonds
BBB50_RS10615	COG5016	pyruvate
BBB50_RS10620	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BBB50_RS10630	COG4565	transcriptional regulatory protein
BBB50_RS10645	COG0583	DNA-binding transcription factor activity
BBB50_RS10655	COG1115	amino acid carrier protein
BBB50_RS10660	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BBB50_RS10665	COG0583	DNA-binding transcription factor activity
BBB50_RS10675	COG1120	ATPase activity
BBB50_RS10680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBB50_RS10685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBB50_RS10690	COG4592	Periplasmic binding protein
BBB50_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
BBB50_RS10705	COG1169	isochorismate synthase
BBB50_RS10710	COG1021	2,3-dihydroxybenzoate-AMP ligase
BBB50_RS10715	COG3433	isochorismatase activity
BBB50_RS10715	COG1535	isochorismatase
BBB50_RS10720	COG1584	GPR1 FUN34 yaaH family protein
BBB50_RS10730	COG0519	Catalyzes the synthesis of GMP from XMP
BBB50_RS10730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BBB50_RS10735	COG0517	IMP dehydrogenase activity
BBB50_RS10735	COG0516	GMP reductase activity
BBB50_RS10740	COG1570	exodeoxyribonuclease VII activity
BBB50_RS10755	COG1160	GTP binding
BBB50_RS10760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBB50_RS10765	COG2976	Protein conserved in bacteria
BBB50_RS10770	COG0124	histidyl-tRNA synthetase
BBB50_RS10775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BBB50_RS10785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BBB50_RS10790	COG0105	UTP biosynthetic process
BBB50_RS10795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BBB50_RS10800	COG2975	iron-sulfur cluster assembly
BBB50_RS10805	COG0633	Ferredoxin
BBB50_RS10810	COG0443	Heat shock 70 kDa protein
BBB50_RS10815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BBB50_RS10825	COG0822	iron-sulfur transferase activity
BBB50_RS10830	COG1104	cysteine desulfurase activity
BBB50_RS10835	COG1959	2 iron, 2 sulfur cluster binding
BBB50_RS10845	COG0483	inositol monophosphate 1-phosphatase activity
BBB50_RS10850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBB50_RS10855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBB50_RS10860	COG1862	Preprotein translocase
BBB50_RS10880	COG0517	IMP dehydrogenase activity
BBB50_RS10890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BBB50_RS10895	COG0583	DNA-binding transcription factor activity
BBB50_RS10900	COG0450	alkyl hydroperoxide reductase
BBB50_RS10905	COG3142	Participates in the control of copper homeostasis
BBB50_RS10920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BBB50_RS10925	COG0581	inorganic phosphate transmembrane transporter activity
BBB50_RS10935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BBB50_RS10940	COG0248	Ppx GppA phosphatase
BBB50_RS10950	COG5002	protein histidine kinase activity
BBB50_RS10955	COG0745	RESPONSE REGULATOR receiver
BBB50_RS10965	COG0826	peptidase U32
BBB50_RS10970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BBB50_RS11015	COG0542	response to heat
BBB50_RS11025	COG0564	pseudouridine synthase activity
BBB50_RS11030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBB50_RS11035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBB50_RS11040	COG0077	Prephenate dehydratase
BBB50_RS11040	COG1605	Chorismate mutase
BBB50_RS11045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBB50_RS11050	COG5001	Diguanylate cyclase
BBB50_RS11060	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BBB50_RS11070	COG0488	(ABC) transporter
BBB50_RS11080	COG1605	Chorismate mutase
BBB50_RS11080	COG0287	Prephenate dehydrogenase
BBB50_RS11085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBB50_RS11090	COG3275	phosphorelay sensor kinase activity
BBB50_RS11095	COG3279	Response regulator of the LytR AlgR family
BBB50_RS11105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BBB50_RS11110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BBB50_RS11125	COG1966	Carbon starvation protein
BBB50_RS11130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BBB50_RS11135	COG1047	Peptidyl-prolyl cis-trans
BBB50_RS11150	COG0196	riboflavin kinase activity
BBB50_RS11155	COG0728	peptidoglycan biosynthetic process
BBB50_RS11160	COG0268	Binds directly to 16S ribosomal RNA
BBB50_RS11165	COG0640	Transcriptional regulator
BBB50_RS11170	COG0583	DNA-binding transcription factor activity
BBB50_RS11175	COG1283	sodium-dependent phosphate transmembrane transporter activity
BBB50_RS11185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BBB50_RS11190	COG0730	response to heat
BBB50_RS11195	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BBB50_RS11200	COG0494	nUDIX hydrolase
BBB50_RS11215	COG0667	Aldo Keto reductase
BBB50_RS11225	COG2204	response regulator
BBB50_RS11230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBB50_RS11235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBB50_RS11250	COG0513	Belongs to the DEAD box helicase family
BBB50_RS11275	COG3153	acetyltransferase
BBB50_RS11280	COG3154	lipid carrier protein
BBB50_RS11290	COG0826	peptidase U32
BBB50_RS11295	COG0826	peptidase U32
BBB50_RS11320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BBB50_RS11330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BBB50_RS11335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BBB50_RS11340	COG0195	Participates in both transcription termination and antitermination
BBB50_RS11345	COG0779	Required for maturation of 30S ribosomal subunits
BBB50_RS11360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBB50_RS11370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBB50_RS11375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBB50_RS11380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BBB50_RS11385	COG1534	Rna-binding protein
BBB50_RS11390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBB50_RS11395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BBB50_RS11400	COG2027	D-alanyl-D-alanine carboxypeptidase
BBB50_RS11405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBB50_RS11410	COG0739	heme binding
BBB50_RS11425	COG0316	Belongs to the HesB IscA family
BBB50_RS11430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BBB50_RS11440	COG0628	permease
BBB50_RS11445	COG2813	Specifically methylates the guanine in position
BBB50_RS11450	COG0784	Response regulator, receiver
BBB50_RS11450	COG2205	protein histidine kinase activity
BBB50_RS11460	COG0747	negative chemotaxis
BBB50_RS11465	COG0601	transmembrane transport
BBB50_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB50_RS11475	COG0444	Belongs to the ABC transporter superfamily
BBB50_RS11480	COG4608	Belongs to the ABC transporter superfamily
BBB50_RS11490	COG2971	BadF BadG BcrA BcrD
BBB50_RS11510	COG3842	ATPase activity
BBB50_RS11520	COG1840	ABC-type Fe3 transport system, periplasmic component
BBB50_RS11525	COG0004	ammonium transporteR
BBB50_RS11530	COG0347	Belongs to the P(II) protein family
BBB50_RS11535	COG3112	Uncharacterised protein family (UPF0231)
BBB50_RS11540	COG1049	propionate catabolic process, 2-methylcitrate cycle
BBB50_RS11545	COG1752	Esterase of the alpha-beta hydrolase superfamily
BBB50_RS11550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBB50_RS11555	COG1643	Atp-dependent helicase
BBB50_RS11565	COG1489	DNA binding
BBB50_RS11575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BBB50_RS11585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBB50_RS11590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BBB50_RS11595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BBB50_RS11600	COG0842	Transport permease protein
BBB50_RS11605	COG1131	(ABC) transporter
BBB50_RS11610	COG0659	secondary active sulfate transmembrane transporter activity
BBB50_RS11615	COG0288	reversible hydration of carbon dioxide
BBB50_RS11630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BBB50_RS11635	COG3107	peptidoglycan biosynthetic process
BBB50_RS11640	COG0792	nuclease activity
BBB50_RS11645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BBB50_RS11650	COG2823	Periplasmic or secreted lipoprotein
BBB50_RS11655	COG2969	positive regulation of protein catabolic process
BBB50_RS11660	COG0625	glutathione transferase activity
BBB50_RS11665	COG2857	Cytochrome c1
BBB50_RS11670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BBB50_RS11675	COG0723	plastoquinol--plastocyanin reductase activity
BBB50_RS11680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BBB50_RS11685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BBB50_RS11695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BBB50_RS11705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBB50_RS11710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBB50_RS11715	COG0335	large ribosomal subunit rRNA binding
BBB50_RS11720	COG0336	Belongs to the RNA methyltransferase TrmD family
BBB50_RS11725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BBB50_RS11730	COG0228	four-way junction DNA binding
BBB50_RS11735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BBB50_RS11740	COG4137	Cytochrome C assembly protein
BBB50_RS11745	COG4536	flavin adenine dinucleotide binding
BBB50_RS11750	COG1854	S-ribosylhomocysteine lyase activity
BBB50_RS11755	COG2918	glutathione biosynthetic process
BBB50_RS11760	COG0612	Peptidase, M16
BBB50_RS11765	COG1238	metal cluster binding
BBB50_RS11775	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BBB50_RS11780	COG5016	pyruvate
BBB50_RS11780	COG0511	ligase activity, forming carbon-carbon bonds
BBB50_RS11785	COG3630	sodium ion export across plasma membrane
BBB50_RS11830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BBB50_RS11835	COG0527	aspartate kinase activity
BBB50_RS11840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BBB50_RS11850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BBB50_RS11860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BBB50_RS11865	COG4208	sulfate ABC transporter
BBB50_RS11885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BBB50_RS11890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBB50_RS11900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BBB50_RS11905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BBB50_RS11910	COG0585	pseudouridine synthase activity
BBB50_RS11915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BBB50_RS11920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BBB50_RS11925	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BBB50_RS11930	COG1968	undecaprenyl-diphosphatase activity
BBB50_RS11935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBB50_RS11940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BBB50_RS11945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BBB50_RS11955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BBB50_RS11960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BBB50_RS11965	COG1610	YqeY-like protein
BBB50_RS11970	COG0358	DNA primase activity
BBB50_RS11990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BBB50_RS11995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBB50_RS12000	COG1349	DNA-binding transcription factor activity
BBB50_RS12020	COG1279	arginine transmembrane transporter activity
BBB50_RS12025	COG0668	transmembrane transport
BBB50_RS12035	COG0191	fructose-bisphosphate aldolase activity
BBB50_RS12040	COG0126	phosphoglycerate kinase activity
BBB50_RS12045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBB50_RS12050	COG4771	TonB-dependent receptor
BBB50_RS12055	COG0583	DNA-binding transcription factor activity
BBB50_RS12060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BBB50_RS12070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BBB50_RS12080	COG2356	endonuclease I
BBB50_RS12085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BBB50_RS12090	COG0189	ligase activity
BBB50_RS12095	COG1678	Uncharacterized ACR, COG1678
BBB50_RS12100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BBB50_RS12105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBB50_RS12125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBB50_RS12130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBB50_RS12135	COG0762	integral membrane protein
BBB50_RS12150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BBB50_RS12155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBB50_RS12160	COG2066	Belongs to the glutaminase family
BBB50_RS12165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BBB50_RS12170	COG1194	a g-specific adenine glycosylase
BBB50_RS12175	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BBB50_RS12180	COG0741	lytic transglycosylase activity
BBB50_RS12205	COG0840	transmembrane signaling receptor activity
BBB50_RS12235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BBB50_RS12240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BBB50_RS12245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBB50_RS12250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BBB50_RS12255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BBB50_RS12260	COG2967	ApaG domain
BBB50_RS12265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BBB50_RS12275	COG3610	response to peptide
BBB50_RS12280	COG2966	Psort location CytoplasmicMembrane, score
BBB50_RS12285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BBB50_RS12290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BBB50_RS12295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BBB50_RS12300	COG0142	geranyltranstransferase activity
BBB50_RS12305	COG0531	amino acid
BBB50_RS12310	COG0039	L-malate dehydrogenase activity
BBB50_RS12315	COG1438	arginine binding
BBB50_RS12320	COG2358	TRAP transporter, solute receptor (TAXI family
BBB50_RS12330	COG0589	response to stress
BBB50_RS12350	COG2235	arginine
BBB50_RS12355	COG0312	modulator of DNA gyrase
BBB50_RS12360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BBB50_RS12365	COG3164	Protein of unknown function
BBB50_RS12375	COG0424	maF-like protein
BBB50_RS12380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BBB50_RS12385	COG1792	Involved in formation and maintenance of cell shape
BBB50_RS12390	COG1077	Cell shape determining protein MreB Mrl
BBB50_RS12420	COG2165	general secretion pathway protein
BBB50_RS12425	COG2165	general secretion pathway protein
BBB50_RS12435	COG1459	type II secretion system
BBB50_RS12440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBB50_RS12450	COG3267	Type II secretory pathway component ExeA
BBB50_RS12450	COG3409	Peptidoglycan-binding domain 1 protein
BBB50_RS12475	COG2199	diguanylate cyclase activity
BBB50_RS12475	COG2200	EAL domain
BBB50_RS12480	COG0629	single-stranded DNA binding
BBB50_RS12495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBB50_RS12505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BBB50_RS12510	COG0527	aspartate kinase activity
BBB50_RS12515	COG1410	methionine synthase
BBB50_RS12515	COG0646	methionine synthase
BBB50_RS12590	COG0175	sulfate reduction
BBB50_RS12600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BBB50_RS12625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBB50_RS12630	COG0735	belongs to the Fur family
BBB50_RS12650	COG0432	Pfam Uncharacterised protein family UPF0047
BBB50_RS12655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBB50_RS12670	COG0359	binds to the 23S rRNA
BBB50_RS12675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BBB50_RS12680	COG2965	DNA replication, synthesis of RNA primer
BBB50_RS12685	COG0360	Binds together with S18 to 16S ribosomal RNA
BBB50_RS12695	COG2906	2 iron, 2 sulfur cluster binding
BBB50_RS12700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBB50_RS12705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BBB50_RS12710	COG0049	tRNA binding
BBB50_RS12715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BBB50_RS12725	COG2923	Belongs to the DsrF TusC family
BBB50_RS12730	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BBB50_RS12735	COG2964	Protein conserved in bacteria
BBB50_RS12740	COG0545	Peptidyl-prolyl cis-trans isomerase
BBB50_RS12750	COG2900	Belongs to the SlyX family
BBB50_RS12755	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BBB50_RS12760	COG0330	HflC and HflK could
BBB50_RS12765	COG0330	HflC and HflK could
BBB50_RS12770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBB50_RS12775	COG1923	regulation of RNA biosynthetic process
BBB50_RS12780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BBB50_RS12785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BBB50_RS12795	COG0802	atpase or kinase
BBB50_RS12800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BBB50_RS12845	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BBB50_RS12850	COG1162	GTPase activity
BBB50_RS12855	COG0688	phosphatidylethanolamine metabolic process
BBB50_RS12860	COG0471	metal ion transport
BBB50_RS12870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BBB50_RS12875	COG4942	peptidase
BBB50_RS12890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BBB50_RS12895	COG2816	NAD+ diphosphatase activity
BBB50_RS12900	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BBB50_RS12905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BBB50_RS12910	COG0085	RNA polymerase activity
BBB50_RS12915	COG0222	ribosome binding
BBB50_RS12920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BBB50_RS12930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BBB50_RS12935	COG0250	Participates in transcription elongation, termination and antitermination
BBB50_RS12940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBB50_RS12945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBB50_RS12970	COG1072	(Pantothenic acid kinase))
BBB50_RS12980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBB50_RS12995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBB50_RS13045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BBB50_RS13060	COG3118	belongs to the thioredoxin family
BBB50_RS13065	COG0513	Belongs to the DEAD box helicase family
BBB50_RS13070	COG0248	Ppx GppA phosphatase
BBB50_RS13075	COG0784	Response regulator, receiver
BBB50_RS13075	COG2205	protein histidine kinase activity
BBB50_RS13080	COG2814	Major facilitator Superfamily
BBB50_RS13100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BBB50_RS13105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBB50_RS13110	COG0511	ligase activity, forming carbon-carbon bonds
BBB50_RS13115	COG0439	Biotin carboxylase
BBB50_RS13125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBB50_RS13130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BBB50_RS13135	COG1609	Transcriptional regulator
BBB50_RS13140	COG0129	dihydroxy-acid dehydratase activity
BBB50_RS13145	COG3265	gluconokinase activity
BBB50_RS13155	COG0800	Aldolase
BBB50_RS13170	COG0840	transmembrane signaling receptor activity
BBB50_RS13175	COG1982	Orn Lys Arg decarboxylase major
BBB50_RS13180	COG0531	amino acid
BBB50_RS13185	COG3710	Transcriptional regulator
BBB50_RS13190	COG0789	Transcriptional regulator
BBB50_RS13200	COG0151	Belongs to the GarS family
BBB50_RS13210	COG0776	regulation of translation
BBB50_RS13220	COG1253	flavin adenine dinucleotide binding
BBB50_RS13225	COG1940	carbohydrate kinase activity
BBB50_RS13235	COG3068	Protein conserved in bacteria
BBB50_RS13245	COG1573	uracil-dna glycosylase
BBB50_RS13250	COG0668	transmembrane transport
BBB50_RS13255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BBB50_RS13260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBB50_RS13290	COG5433	transposase activity
BBB50_RS13305	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS13305	COG1454	alcohol dehydrogenase
BBB50_RS13310	COG0318	PFAM AMP-dependent synthetase and ligase
BBB50_RS13340	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BBB50_RS13345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBB50_RS13350	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BBB50_RS13350	COG0662	Cupin 2, conserved barrel domain protein
BBB50_RS13355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBB50_RS13390	COG1519	Transferase
BBB50_RS13420	COG3642	lipopolysaccharide core region biosynthetic process
BBB50_RS13425	COG0859	PFAM glycosyl transferase family 9
BBB50_RS13430	COG0463	Glycosyl transferase, family 2
BBB50_RS13435	COG0859	PFAM glycosyl transferase family 9
BBB50_RS13440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BBB50_RS13445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBB50_RS13455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BBB50_RS13460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BBB50_RS13465	COG2003	Belongs to the UPF0758 family
BBB50_RS13475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBB50_RS13480	COG1309	transcriptional regulator
BBB50_RS13485	COG1560	Kdo2-lipid A biosynthetic process
BBB50_RS13490	COG1560	Kdo2-lipid A biosynthetic process
BBB50_RS13495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBB50_RS13500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BBB50_RS13505	COG1561	YicC-like family, N-terminal region
BBB50_RS13510	COG2862	Uncharacterized protein family, UPF0114
BBB50_RS13515	COG1263	PTS System
BBB50_RS13515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBB50_RS13520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BBB50_RS13545	COG1120	ATPase activity
BBB50_RS13550	COG4774	siderophore transport
BBB50_RS13555	COG1132	(ABC) transporter
BBB50_RS13570	COG0514	ATP-dependent DNA helicase (RecQ)
BBB50_RS13575	COG2962	Rard protein
BBB50_RS13590	COG1280	lysine exporter protein (LysE YggA)
BBB50_RS13595	COG0210	DNA helicase
BBB50_RS13605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BBB50_RS13610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBB50_RS13620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBB50_RS13625	COG0601	transmembrane transport
BBB50_RS13630	COG0747	negative chemotaxis
BBB50_RS13685	COG1309	transcriptional regulator
BBB50_RS13690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBB50_RS13695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBB50_RS13700	COG2960	long-chain fatty acid transporting porin activity
BBB50_RS13705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BBB50_RS13710	COG0583	DNA-binding transcription factor activity
BBB50_RS13785	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BBB50_RS13790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBB50_RS13795	COG1739	Uncharacterized protein family UPF0029
BBB50_RS13805	COG0183	Belongs to the thiolase family
BBB50_RS13810	COG0583	DNA-binding transcription factor activity
BBB50_RS13815	COG2814	Major facilitator Superfamily
BBB50_RS13825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBB50_RS13830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BBB50_RS13835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BBB50_RS13840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BBB50_RS13845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBB50_RS13850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BBB50_RS13860	COG0356	it plays a direct role in the translocation of protons across the membrane
BBB50_RS13865	COG3312	ion transport
BBB50_RS13870	COG1475	DNA binding
BBB50_RS13875	COG1192	Involved in chromosome partitioning
BBB50_RS13885	COG0445	tRNA wobble uridine modification
BBB50_RS13895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BBB50_RS13900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BBB50_RS13905	COG0706	membrane insertase activity
BBB50_RS13915	COG0594	ribonuclease P activity
BBB50_RS13920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BBB50_RS13925	COG1126	abc transporter atp-binding protein
BBB50_RS13955	COG0187	DNA topoisomerase II activity
BBB50_RS13960	COG0187	DNA topoisomerase II activity
BBB50_RS13965	COG0187	DNA topoisomerase II activity
BBB50_RS14060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBB50_RS14060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBB50_RS14165	COG0006	proline dipeptidase activity
BBB50_RS14165	COG0006	proline dipeptidase activity
BBB50_RS14195	COG5001	Diguanylate cyclase
BBB50_RS14195	COG5002	protein histidine kinase activity
BBB50_RS14195	COG3447	MASE1 domain protein
BBB50_RS14425	COG3287	FIST C domain
BBB50_RS14425	COG2200	EAL domain
BBB50_RS14425	COG2199	diguanylate cyclase activity
BBB50_RS14650	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BBB50_RS14685	COG2165	general secretion pathway protein
BBB50_RS14700	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
BBB50_RS15105	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBB50_RS15560	COG0051	transcription antitermination factor activity, RNA binding
BBB50_RS15630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BBB50_RS15660	COG3266	domain, Protein
BBB50_RS15660	COG3061	Opacity-associated protein A
BBB50_RS15675	COG0513	Belongs to the DEAD box helicase family
BBB50_RS15830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBB50_RS15965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BBB50_RS16040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBB50_RS16130	COG3437	response regulator, receiver
BBB50_RS16275	COG1022	Amp-dependent synthetase and ligase
BBB50_RS16390	COG0504	CTP synthase activity
BBB50_RS16415	COG3267	Type II secretory pathway component ExeA
BBB50_RS16415	COG3409	Peptidoglycan-binding domain 1 protein
BBB50_RS16625	COG0768	penicillin binding
BBB50_RS16735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BBB50_RS16815	COG0067	glutamate synthase
BBB50_RS16815	COG0069	glutamate synthase activity
BBB50_RS16815	COG0070	glutamate synthase
BBB50_RS17055	COG3250	beta-galactosidase activity
BBB50_RS17445	COG0587	DNA-directed DNA polymerase activity
BBB50_RS17640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BBB50_RS17640	COG3433	isochorismatase activity
BBB50_RS17640	COG2226	methyltransferase
BBB50_RS17705	COG0784	Response regulator, receiver
BBB50_RS17705	COG0835	chemotaxis
BBB50_RS17915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BBB50_RS18145	COG1121	(ABC) transporter
BBB50_RS18190	COG0018	arginyl-trna synthetase
BBB50_RS18255	COG0643	Histidine kinase
BBB50_RS18255	COG2198	Histidine kinase
BBB50_RS18255	COG0784	Response regulator, receiver
BBB50_RS18390	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS18390	COG1454	alcohol dehydrogenase
BBB50_RS18400	COG1454	alcohol dehydrogenase
BBB50_RS18400	COG1012	belongs to the aldehyde dehydrogenase family
BBB50_RS18660	COG0436	Aminotransferase
BBB50_RS18890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BBB50_RS19150	COG2718	Belongs to the UPF0229 family