locus-tag	class	description
GPW66_RS00060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPW66_RS00060	COG0456	acetyltransferase
GPW66_RS00090	COG0456	acetyltransferase
GPW66_RS00165	COG1335	isochorismatase
GPW66_RS00180	COG0346	lactoylglutathione lyase activity
GPW66_RS00230	COG1942	4-Oxalocrotonate Tautomerase
GPW66_RS00260	COG0456	acetyltransferase
GPW66_RS00285	COG0653	protein targeting
GPW66_RS00305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW66_RS00350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPW66_RS00355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPW66_RS00365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPW66_RS00370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPW66_RS00380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW66_RS00385	COG0509	glycine decarboxylation via glycine cleavage system
GPW66_RS00390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW66_RS00390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW66_RS00395	COG3385	transposase activity
GPW66_RS00415	COG1686	Belongs to the peptidase S11 family
GPW66_RS00430	COG2814	Major facilitator Superfamily
GPW66_RS00470	COG5002	protein histidine kinase activity
GPW66_RS00470	COG5000	phosphorelay sensor kinase activity
GPW66_RS00475	COG0745	RESPONSE REGULATOR receiver
GPW66_RS00495	COG0366	Alpha amylase catalytic
GPW66_RS00530	COG0561	phosphatase activity
GPW66_RS00535	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPW66_RS00540	COG3623	hexulose-6-phosphate isomerase
GPW66_RS00550	COG0745	RESPONSE REGULATOR receiver
GPW66_RS00565	COG0583	DNA-binding transcription factor activity
GPW66_RS00595	COG1401	restriction endodeoxyribonuclease activity
GPW66_RS00605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPW66_RS00610	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GPW66_RS00620	COG1943	Transposase
GPW66_RS00625	COG3385	transposase activity
GPW66_RS00630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW66_RS00650	COG4604	ABC transporter, ATP-binding protein
GPW66_RS00655	COG4605	iron ion homeostasis
GPW66_RS00660	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW66_RS00685	COG3291	Pkd domain containing protein
GPW66_RS00685	COG4412	M6 family metalloprotease domain protein
GPW66_RS00690	COG5380	lipid catabolic process
GPW66_RS00695	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPW66_RS00700	COG0840	transmembrane signaling receptor activity
GPW66_RS00710	COG3240	lipase activity
GPW66_RS00715	COG3706	GGDEF domain
GPW66_RS00725	COG2814	Major facilitator Superfamily
GPW66_RS00730	COG1757	Na H antiporter
GPW66_RS00740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW66_RS00740	COG4191	Histidine kinase
GPW66_RS00745	COG0784	Response regulator, receiver
GPW66_RS00745	COG3437	response regulator, receiver
GPW66_RS00750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPW66_RS00755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPW66_RS00760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW66_RS00765	COG0513	Belongs to the DEAD box helicase family
GPW66_RS00790	COG0516	GMP reductase activity
GPW66_RS00800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW66_RS00810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW66_RS00815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPW66_RS00815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPW66_RS00840	COG3036	rescue of stalled ribosome
GPW66_RS00845	COG1278	Cold shock
GPW66_RS00850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW66_RS00850	COG1017	nitric oxide dioxygenase activity
GPW66_RS00855	COG3604	Transcriptional regulator
GPW66_RS00865	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW66_RS00870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW66_RS00885	COG0840	transmembrane signaling receptor activity
GPW66_RS00890	COG0714	Associated with various cellular activities
GPW66_RS00910	COG2304	oxidoreductase activity
GPW66_RS00925	COG1278	Cold shock
GPW66_RS00930	COG5001	Diguanylate cyclase
GPW66_RS00930	COG5002	protein histidine kinase activity
GPW66_RS00940	COG3530	Putative quorum-sensing-regulated virulence factor
GPW66_RS00950	COG3033	Beta-eliminating lyase
GPW66_RS00955	COG0814	amino acid
GPW66_RS00960	COG0589	response to stress
GPW66_RS00970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW66_RS00970	COG2111	Na H antiporter
GPW66_RS00990	COG2212	antiporter activity
GPW66_RS00995	COG1320	monovalent cation:proton antiporter activity
GPW66_RS01000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW66_RS01000	COG1017	nitric oxide dioxygenase activity
GPW66_RS01005	COG0242	peptide deformylase activity
GPW66_RS01010	COG3385	transposase activity
GPW66_RS01020	COG0579	oxidoreductase
GPW66_RS01060	COG2271	Major facilitator Superfamily
GPW66_RS01065	COG0584	glycerophosphoryl diester phosphodiesterase
GPW66_RS01075	COG0813	purine-nucleoside phosphorylase activity
GPW66_RS01085	COG1609	Transcriptional regulator
GPW66_RS01090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW66_RS01095	COG1879	ABC-type sugar transport system periplasmic component
GPW66_RS01100	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPW66_RS01105	COG1129	ABC transporter
GPW66_RS01110	COG1869	D-ribose catabolic process
GPW66_RS01130	COG3501	Rhs element vgr protein
GPW66_RS01225	COG0564	pseudouridine synthase activity
GPW66_RS01235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW66_RS01240	COG2771	luxR family
GPW66_RS01240	COG2200	EAL domain
GPW66_RS01250	COG0673	inositol 2-dehydrogenase activity
GPW66_RS01255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPW66_RS01285	COG1342	Belongs to the UPF0251 family
GPW66_RS01295	COG1301	dicarboxylic acid transport
GPW66_RS01320	COG2814	Major facilitator Superfamily
GPW66_RS01325	COG0583	DNA-binding transcription factor activity
GPW66_RS01330	COG5001	Diguanylate cyclase
GPW66_RS01330	COG3300	MHYT domain
GPW66_RS01335	COG0739	heme binding
GPW66_RS01345	COG0659	secondary active sulfate transmembrane transporter activity
GPW66_RS01365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW66_RS01370	COG0581	inorganic phosphate transmembrane transporter activity
GPW66_RS01375	COG0573	inorganic phosphate transmembrane transporter activity
GPW66_RS01380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW66_RS01410	COG1770	oligopeptidase
GPW66_RS01415	COG0513	Belongs to the DEAD box helicase family
GPW66_RS01425	COG1388	LysM domain
GPW66_RS01425	COG1376	ErfK ybiS ycfS ynhG family protein
GPW66_RS01430	COG0415	Belongs to the DNA photolyase family
GPW66_RS01440	COG3272	Protein of unknown function (DUF1722)
GPW66_RS01445	COG0813	purine-nucleoside phosphorylase activity
GPW66_RS01460	COG3706	GGDEF domain
GPW66_RS01480	COG0786	glutamate:sodium symporter activity
GPW66_RS01495	COG1999	signal sequence binding
GPW66_RS01505	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPW66_RS01510	COG0671	phosphoesterase, PA-phosphatase related
GPW66_RS01555	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW66_RS01560	COG0471	metal ion transport
GPW66_RS01595	COG3501	Rhs element vgr protein
GPW66_RS01605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPW66_RS01610	COG1640	4-alpha-glucanotransferase
GPW66_RS01615	COG0058	SHG alpha-glucan phosphorylase activity
GPW66_RS01620	COG2909	trisaccharide binding
GPW66_RS01640	COG2084	Dehydrogenase
GPW66_RS01645	COG0217	transcriptional regulatory protein
GPW66_RS01680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW66_RS01685	COG1444	tRNA N-acetyltransferase activity
GPW66_RS01715	COG0745	RESPONSE REGULATOR receiver
GPW66_RS01720	COG0642	Histidine kinase
GPW66_RS01725	COG2194	sulfuric ester hydrolase activity
GPW66_RS01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW66_RS01740	COG0601	transmembrane transport
GPW66_RS01745	COG0747	negative chemotaxis
GPW66_RS01760	COG2198	Histidine kinase
GPW66_RS01760	COG0643	Histidine kinase
GPW66_RS01765	COG0835	chemotaxis
GPW66_RS01770	COG0835	chemotaxis
GPW66_RS01775	COG0840	transmembrane signaling receptor activity
GPW66_RS01780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW66_RS01785	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPW66_RS01805	COG0745	RESPONSE REGULATOR receiver
GPW66_RS01835	COG0259	pyridoxamine-phosphate oxidase activity
GPW66_RS01845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPW66_RS01870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW66_RS01905	COG2409	Drug exporters of the RND superfamily
GPW66_RS01910	COG2197	response regulator
GPW66_RS01920	COG1982	Orn Lys Arg decarboxylase major
GPW66_RS01925	COG0531	amino acid
GPW66_RS01935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW66_RS01940	COG1901	pseudouridine methyltransferase
GPW66_RS01950	COG4221	oxidoreductase activity
GPW66_RS01955	COG0840	transmembrane signaling receptor activity
GPW66_RS01965	COG2910	NAD(P)H-binding
GPW66_RS01995	COG0673	inositol 2-dehydrogenase activity
GPW66_RS02000	COG3722	fumarate hydratase activity
GPW66_RS02005	COG0246	Mannitol dehydrogenase
GPW66_RS02010	COG2213	PTS system mannitol-specific
GPW66_RS02010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW66_RS02020	COG0739	heme binding
GPW66_RS02030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW66_RS02035	COG4597	amino acid ABC transporter
GPW66_RS02040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW66_RS02050	COG1126	abc transporter atp-binding protein
GPW66_RS02055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW66_RS02065	COG0840	transmembrane signaling receptor activity
GPW66_RS02075	COG0840	transmembrane signaling receptor activity
GPW66_RS02090	COG4580	involved in the transport of maltose and maltodextrins
GPW66_RS02105	COG0363	glucosamine-6-phosphate deaminase activity
GPW66_RS02130	COG2259	Doxx family
GPW66_RS02135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPW66_RS02140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPW66_RS02150	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPW66_RS02155	COG3366	ferrous iron transmembrane transporter activity
GPW66_RS02160	COG0700	Nucleoside recognition
GPW66_RS02170	COG0697	spore germination
GPW66_RS02175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW66_RS02180	COG1764	response to oxidative stress
GPW66_RS02185	COG1846	Transcriptional regulator
GPW66_RS02205	COG2207	Transcriptional regulator
GPW66_RS02210	COG1280	lysine exporter protein (LysE YggA)
GPW66_RS02220	COG1902	pentaerythritol trinitrate reductase activity
GPW66_RS02230	COG1132	(ABC) transporter
GPW66_RS02245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPW66_RS02255	COG0513	Belongs to the DEAD box helicase family
GPW66_RS02275	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPW66_RS02285	COG1304	FMN binding
GPW66_RS02290	COG1620	l-lactate permease
GPW66_RS02295	COG0583	DNA-binding transcription factor activity
GPW66_RS02315	COG4172	Belongs to the ABC transporter superfamily
GPW66_RS02325	COG1067	ATP-dependent peptidase activity
GPW66_RS02340	COG2211	Major facilitator Superfamily
GPW66_RS02350	COG3123	guanosine phosphorylase activity
GPW66_RS02355	COG1741	Belongs to the pirin family
GPW66_RS02365	COG5001	Diguanylate cyclase
GPW66_RS02370	COG0583	DNA-binding transcription factor activity
GPW66_RS02405	COG3706	GGDEF domain
GPW66_RS02410	COG1846	Transcriptional regulator
GPW66_RS02415	COG0784	Response regulator, receiver
GPW66_RS02415	COG0835	chemotaxis
GPW66_RS02420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW66_RS02425	COG2197	response regulator
GPW66_RS02430	COG0393	Putative heavy-metal-binding
GPW66_RS02445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW66_RS02450	COG3842	ATPase activity
GPW66_RS02460	COG1175	transmembrane transport
GPW66_RS02465	COG3833	ABC-type maltose transport systems, permease component
GPW66_RS02480	COG1349	DNA-binding transcription factor activity
GPW66_RS02485	COG3706	GGDEF domain
GPW66_RS02495	COG2207	Transcriptional regulator
GPW66_RS02495	COG4753	response regulator
GPW66_RS02510	COG1278	Cold shock
GPW66_RS02515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW66_RS02520	COG2354	Protein conserved in bacteria
GPW66_RS02525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW66_RS02530	COG0418	dihydroorotase activity
GPW66_RS02535	COG3217	Mosc domain protein beta barrel domain protein
GPW66_RS02535	COG0633	Ferredoxin
GPW66_RS02535	COG0633	Ferredoxin
GPW66_RS02535	COG3217	Mosc domain protein beta barrel domain protein
GPW66_RS02570	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPW66_RS02575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW66_RS02580	COG4558	Periplasmic binding protein
GPW66_RS02585	COG0848	biopolymer transport protein
GPW66_RS02590	COG0811	peptide transport
GPW66_RS02595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW66_RS02605	COG3721	Heme iron utilization protein
GPW66_RS02610	COG0748	coenzyme F420 binding
GPW66_RS02620	COG1929	Belongs to the glycerate kinase type-1 family
GPW66_RS02645	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPW66_RS02650	COG0363	glucosamine-6-phosphate deaminase activity
GPW66_RS02655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPW66_RS02660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW66_RS02685	COG0346	lactoylglutathione lyase activity
GPW66_RS02695	COG2873	o-acetylhomoserine
GPW66_RS02700	COG0156	8-amino-7-oxononanoate synthase activity
GPW66_RS02705	COG1063	alcohol dehydrogenase
GPW66_RS02710	COG0789	Transcriptional regulator
GPW66_RS02725	COG0583	DNA-binding transcription factor activity
GPW66_RS02730	COG3048	D-serine ammonia-lyase activity
GPW66_RS02740	COG1278	Cold shock
GPW66_RS02745	COG0557	exoribonuclease II activity
GPW66_RS02750	COG1686	Belongs to the peptidase S11 family
GPW66_RS02760	COG3047	cAMP biosynthetic process
GPW66_RS02770	COG3227	Zinc metalloprotease (Elastase)
GPW66_RS02780	COG2267	carboxylic ester hydrolase activity
GPW66_RS02785	COG2067	long-chain fatty acid transport protein
GPW66_RS02795	COG0366	Alpha amylase catalytic
GPW66_RS02800	COG4989	oxidoreductase activity
GPW66_RS02815	COG3706	GGDEF domain
GPW66_RS02820	COG0531	amino acid
GPW66_RS02825	COG1252	NADH dehydrogenase
GPW66_RS02855	COG1765	OsmC-like protein
GPW66_RS02860	COG1253	flavin adenine dinucleotide binding
GPW66_RS02865	COG2171	N-acyltransferase activity
GPW66_RS02880	COG0583	DNA-binding transcription factor activity
GPW66_RS02885	COG2264	protein methyltransferase activity
GPW66_RS02900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW66_RS02905	COG3186	Phenylalanine-4-hydroxylase
GPW66_RS02910	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPW66_RS02915	COG0456	acetyltransferase
GPW66_RS02920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPW66_RS02925	COG0662	Cupin 2, conserved barrel domain protein
GPW66_RS02930	COG0527	aspartate kinase activity
GPW66_RS02940	COG0459	protein refolding
GPW66_RS02945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW66_RS02950	COG2239	Acts as a magnesium transporter
GPW66_RS02965	COG1166	arginine decarboxylase activity
GPW66_RS02970	COG0010	Belongs to the arginase family
GPW66_RS02980	COG3227	Zinc metalloprotease (Elastase)
GPW66_RS02985	COG3397	chitin binding
GPW66_RS02990	COG3046	protein related to deoxyribodipyrimidine photolyase
GPW66_RS03000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW66_RS03010	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPW66_RS03015	COG0513	Belongs to the DEAD box helicase family
GPW66_RS03025	COG1368	sulfuric ester hydrolase activity
GPW66_RS03030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW66_RS03095	COG0484	heat shock protein binding
GPW66_RS03110	COG1716	ATPase activity
GPW66_RS03110	COG5001	Diguanylate cyclase
GPW66_RS03115	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW66_RS03125	COG4181	ATPase activity
GPW66_RS03130	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPW66_RS03145	COG1984	allophanate hydrolase subunit 2
GPW66_RS03155	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPW66_RS03160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPW66_RS03165	COG0840	transmembrane signaling receptor activity
GPW66_RS03170	COG0814	amino acid
GPW66_RS03180	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPW66_RS03185	COG0513	Belongs to the DEAD box helicase family
GPW66_RS03190	COG1309	transcriptional regulator
GPW66_RS03200	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPW66_RS03205	COG0494	nUDIX hydrolase
GPW66_RS03215	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPW66_RS03225	COG1126	abc transporter atp-binding protein
GPW66_RS03230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW66_RS03235	COG4215	(ABC) transporter
GPW66_RS03240	COG4160	amino acid transport
GPW66_RS03245	COG0583	DNA-binding transcription factor activity
GPW66_RS03275	COG3118	belongs to the thioredoxin family
GPW66_RS03280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW66_RS03285	COG0247	lactate metabolic process
GPW66_RS03295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW66_RS03300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPW66_RS03305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPW66_RS03330	COG3132	Protein of unknown function, DUF480
GPW66_RS03335	COG2827	Endonuclease containing a URI domain
GPW66_RS03345	COG1879	ABC-type sugar transport system periplasmic component
GPW66_RS03350	COG0784	Response regulator, receiver
GPW66_RS03350	COG5002	protein histidine kinase activity
GPW66_RS03390	COG1492	cobalamin metabolic process
GPW66_RS03395	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPW66_RS03400	COG4149	molybdate abc transporter
GPW66_RS03405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPW66_RS03435	COG1289	transmembrane transporter activity
GPW66_RS03440	COG0210	DNA helicase
GPW66_RS03445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPW66_RS03450	COG1335	isochorismatase
GPW66_RS03455	COG1803	Methylglyoxal synthase
GPW66_RS03460	COG1879	ABC-type sugar transport system periplasmic component
GPW66_RS03465	COG2205	protein histidine kinase activity
GPW66_RS03465	COG2198	Histidine kinase
GPW66_RS03465	COG0784	Response regulator, receiver
GPW66_RS03470	COG0469	pyruvate kinase activity
GPW66_RS03475	COG2271	Major facilitator Superfamily
GPW66_RS03480	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW66_RS03485	COG4191	Histidine kinase
GPW66_RS03500	COG1979	alcohol dehydrogenase
GPW66_RS03510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW66_RS03515	COG3706	GGDEF domain
GPW66_RS03530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW66_RS03535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW66_RS03545	COG0183	Belongs to the thiolase family
GPW66_RS03555	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPW66_RS03560	COG3842	ATPase activity
GPW66_RS03570	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW66_RS03575	COG2271	Major facilitator Superfamily
GPW66_RS03580	COG3851	Histidine kinase
GPW66_RS03585	COG2197	response regulator
GPW66_RS03590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW66_RS03610	COG0243	molybdopterin cofactor binding
GPW66_RS03620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW66_RS03625	COG3850	Histidine kinase
GPW66_RS03630	COG2197	response regulator
GPW66_RS03635	COG1760	l-serine dehydratase
GPW66_RS03640	COG3069	C4-dicarboxylate transmembrane transporter activity
GPW66_RS03645	COG0840	transmembrane signaling receptor activity
GPW66_RS03650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW66_RS03655	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW66_RS03660	COG2885	chlorophyll binding
GPW66_RS03670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW66_RS03675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW66_RS03680	COG1621	beta-fructofuranosidase activity
GPW66_RS03690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW66_RS03690	COG1263	PTS System
GPW66_RS03735	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW66_RS03745	COG0640	Transcriptional regulator
GPW66_RS03775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPW66_RS03780	COG0583	DNA-binding transcription factor activity
GPW66_RS03805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW66_RS03830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW66_RS03835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPW66_RS03845	COG2390	Transcriptional regulator
GPW66_RS03850	COG2897	thiosulfate sulfurtransferase activity
GPW66_RS03860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW66_RS03870	COG0302	gtp cyclohydrolase
GPW66_RS03875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW66_RS03875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW66_RS03880	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPW66_RS03885	COG1970	mechanosensitive ion channel activity
GPW66_RS03890	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPW66_RS03900	COG1011	Hydrolase
GPW66_RS03905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW66_RS03910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW66_RS03920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW66_RS03930	COG3842	ATPase activity
GPW66_RS03975	COG4166	transmembrane transport
GPW66_RS03980	COG4174	ABC transporter (Permease)
GPW66_RS03985	COG4239	(ABC) transporter, permease
GPW66_RS03990	COG4172	Belongs to the ABC transporter superfamily
GPW66_RS03995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPW66_RS04010	COG0625	glutathione transferase activity
GPW66_RS04030	COG2050	protein possibly involved in aromatic compounds catabolism
GPW66_RS04045	COG1629	transport
GPW66_RS04045	COG4771	TonB-dependent receptor
GPW66_RS04050	COG0583	DNA-binding transcription factor activity
GPW66_RS04055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW66_RS04055	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW66_RS04055	COG1042	CoA-binding domain protein
GPW66_RS04065	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPW66_RS04075	COG0023	Translation Initiation Factor
GPW66_RS04095	COG0745	RESPONSE REGULATOR receiver
GPW66_RS04105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPW66_RS04110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPW66_RS04125	COG3706	GGDEF domain
GPW66_RS04180	COG2824	Alkylphosphonate utilization operon protein PhnA
GPW66_RS04195	COG0737	Belongs to the 5'-nucleotidase family
GPW66_RS04200	COG3593	DNA synthesis involved in DNA repair
GPW66_RS04210	COG0583	DNA-binding transcription factor activity
GPW66_RS04215	COG2116	formate transmembrane transporter activity
GPW66_RS04225	COG3038	cytochrome b561
GPW66_RS04235	COG2200	EAL domain
GPW66_RS04245	COG0586	Pfam SNARE associated Golgi protein
GPW66_RS04250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW66_RS04255	COG0745	RESPONSE REGULATOR receiver
GPW66_RS04260	COG2205	protein histidine kinase activity
GPW66_RS04265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPW66_RS04265	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPW66_RS04265	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPW66_RS04265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPW66_RS04270	COG3158	transport of potassium into the cell
GPW66_RS04280	COG0523	cobalamin synthesis protein
GPW66_RS04285	COG0038	chloride channel
GPW66_RS04295	COG0156	8-amino-7-oxononanoate synthase activity
GPW66_RS04300	COG0784	Response regulator, receiver
GPW66_RS04300	COG2205	protein histidine kinase activity
GPW66_RS04305	COG0419	ATPase involved in DNA repair
GPW66_RS04310	COG0420	3'-5' exonuclease activity
GPW66_RS04315	COG1609	Transcriptional regulator
GPW66_RS04320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW66_RS04320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW66_RS04325	COG1105	Belongs to the carbohydrate kinase PfkB family
GPW66_RS04330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPW66_RS04330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW66_RS04330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW66_RS04335	COG4067	protein conserved in archaea
GPW66_RS04335	COG0189	ligase activity
GPW66_RS04345	COG0602	queuosine metabolic process
GPW66_RS04350	COG1328	CTP reductase activity
GPW66_RS04420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW66_RS04475	COG0456	acetyltransferase
GPW66_RS04525	COG0110	maltose O-acetyltransferase activity
GPW66_RS04690	COG4785	May be involved in cell division
GPW66_RS04695	COG1185	polyribonucleotide nucleotidyltransferase activity
GPW66_RS04700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPW66_RS04705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPW66_RS04710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPW66_RS04715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPW66_RS04720	COG0195	Participates in both transcription termination and antitermination
GPW66_RS04725	COG0779	Required for maturation of 30S ribosomal subunits
GPW66_RS04740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW66_RS04745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW66_RS04750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPW66_RS04755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPW66_RS04760	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPW66_RS04765	COG1534	Rna-binding protein
GPW66_RS04770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW66_RS04775	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW66_RS04780	COG2027	D-alanyl-D-alanine carboxypeptidase
GPW66_RS04785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW66_RS04790	COG0739	heme binding
GPW66_RS04805	COG0316	Belongs to the HesB IscA family
GPW66_RS04810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPW66_RS04820	COG0628	permease
GPW66_RS04825	COG2813	Specifically methylates the guanine in position
GPW66_RS04835	COG0747	negative chemotaxis
GPW66_RS04845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW66_RS04850	COG0444	Belongs to the ABC transporter superfamily
GPW66_RS04855	COG4608	Belongs to the ABC transporter superfamily
GPW66_RS04865	COG2971	BadF BadG BcrA BcrD
GPW66_RS04880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW66_RS04885	COG3842	ATPase activity
GPW66_RS04895	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW66_RS04900	COG0004	ammonium transporteR
GPW66_RS04905	COG0347	Belongs to the P(II) protein family
GPW66_RS04910	COG3112	Uncharacterised protein family (UPF0231)
GPW66_RS04915	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPW66_RS04920	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPW66_RS04925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPW66_RS04930	COG1643	Atp-dependent helicase
GPW66_RS04940	COG1489	DNA binding
GPW66_RS04945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPW66_RS04950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW66_RS04960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW66_RS04965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPW66_RS04970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPW66_RS04975	COG0842	Transport permease protein
GPW66_RS04980	COG1131	(ABC) transporter
GPW66_RS04985	COG0659	secondary active sulfate transmembrane transporter activity
GPW66_RS04990	COG0288	reversible hydration of carbon dioxide
GPW66_RS05005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPW66_RS05010	COG3107	peptidoglycan biosynthetic process
GPW66_RS05015	COG0792	nuclease activity
GPW66_RS05020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW66_RS05025	COG2823	Periplasmic or secreted lipoprotein
GPW66_RS05030	COG2969	positive regulation of protein catabolic process
GPW66_RS05035	COG0625	glutathione transferase activity
GPW66_RS05040	COG2857	Cytochrome c1
GPW66_RS05045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPW66_RS05050	COG0723	plastoquinol--plastocyanin reductase activity
GPW66_RS05055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPW66_RS05060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPW66_RS05065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPW66_RS05075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW66_RS05080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW66_RS05085	COG0335	large ribosomal subunit rRNA binding
GPW66_RS05090	COG0336	Belongs to the RNA methyltransferase TrmD family
GPW66_RS05095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPW66_RS05100	COG0228	four-way junction DNA binding
GPW66_RS05105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPW66_RS05110	COG4137	Cytochrome C assembly protein
GPW66_RS05115	COG4536	flavin adenine dinucleotide binding
GPW66_RS05120	COG1854	S-ribosylhomocysteine lyase activity
GPW66_RS05125	COG2918	glutathione biosynthetic process
GPW66_RS05130	COG0612	Peptidase, M16
GPW66_RS05135	COG1238	metal cluster binding
GPW66_RS05145	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW66_RS05150	COG0511	ligase activity, forming carbon-carbon bonds
GPW66_RS05150	COG5016	pyruvate
GPW66_RS05155	COG3630	sodium ion export across plasma membrane
GPW66_RS05200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPW66_RS05205	COG0527	aspartate kinase activity
GPW66_RS05210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPW66_RS05215	COG2137	regulation of response to DNA damage stimulus
GPW66_RS05220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPW66_RS05230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPW66_RS05235	COG4208	sulfate ABC transporter
GPW66_RS05255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPW66_RS05260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW66_RS05265	COG1388	LysM domain
GPW66_RS05265	COG4942	peptidase
GPW66_RS05270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPW66_RS05275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPW66_RS05280	COG0585	pseudouridine synthase activity
GPW66_RS05285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPW66_RS05290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPW66_RS05295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPW66_RS05300	COG1968	undecaprenyl-diphosphatase activity
GPW66_RS05305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW66_RS05310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPW66_RS05315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPW66_RS05325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPW66_RS05330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPW66_RS05335	COG1610	YqeY-like protein
GPW66_RS05340	COG0358	DNA primase activity
GPW66_RS05345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW66_RS05360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW66_RS05365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPW66_RS05370	COG1349	DNA-binding transcription factor activity
GPW66_RS05375	COG0469	pyruvate kinase activity
GPW66_RS05385	COG0583	DNA-binding transcription factor activity
GPW66_RS05390	COG1279	arginine transmembrane transporter activity
GPW66_RS05395	COG0668	transmembrane transport
GPW66_RS05405	COG0191	fructose-bisphosphate aldolase activity
GPW66_RS05410	COG0126	phosphoglycerate kinase activity
GPW66_RS05415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW66_RS05420	COG4771	TonB-dependent receptor
GPW66_RS05425	COG0583	DNA-binding transcription factor activity
GPW66_RS05430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW66_RS05435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPW66_RS05440	COG3091	SprT-like family
GPW66_RS05445	COG2356	endonuclease I
GPW66_RS05450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPW66_RS05455	COG0189	ligase activity
GPW66_RS05460	COG1678	Uncharacterized ACR, COG1678
GPW66_RS05465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPW66_RS05470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW66_RS05490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPW66_RS05495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPW66_RS05500	COG0762	integral membrane protein
GPW66_RS05515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPW66_RS05520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW66_RS05525	COG2066	Belongs to the glutaminase family
GPW66_RS05530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPW66_RS05535	COG1194	a g-specific adenine glycosylase
GPW66_RS05540	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPW66_RS05545	COG0741	lytic transglycosylase activity
GPW66_RS05570	COG0840	transmembrane signaling receptor activity
GPW66_RS05600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW66_RS05605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPW66_RS05610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW66_RS05615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPW66_RS05620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPW66_RS05625	COG2967	ApaG domain
GPW66_RS05630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPW66_RS05640	COG3610	response to peptide
GPW66_RS05645	COG2966	Psort location CytoplasmicMembrane, score
GPW66_RS05650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPW66_RS05655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPW66_RS05660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPW66_RS05665	COG0142	geranyltranstransferase activity
GPW66_RS05670	COG0531	amino acid
GPW66_RS05675	COG0039	L-malate dehydrogenase activity
GPW66_RS05680	COG1438	arginine binding
GPW66_RS05695	COG0589	response to stress
GPW66_RS05715	COG2235	arginine
GPW66_RS05720	COG0312	modulator of DNA gyrase
GPW66_RS05725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPW66_RS05730	COG3164	Protein of unknown function
GPW66_RS05735	COG1530	ribonuclease E activity
GPW66_RS05740	COG0424	maF-like protein
GPW66_RS05745	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPW66_RS05750	COG1792	Involved in formation and maintenance of cell shape
GPW66_RS05755	COG1077	Cell shape determining protein MreB Mrl
GPW66_RS05800	COG1459	type II secretion system
GPW66_RS05805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW66_RS05815	COG3267	Type II secretory pathway component ExeA
GPW66_RS05815	COG3409	Peptidoglycan-binding domain 1 protein
GPW66_RS05840	COG2200	EAL domain
GPW66_RS05840	COG2199	diguanylate cyclase activity
GPW66_RS05845	COG0629	single-stranded DNA binding
GPW66_RS05860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPW66_RS05875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW66_RS05880	COG0527	aspartate kinase activity
GPW66_RS05885	COG0646	methionine synthase
GPW66_RS05885	COG1410	methionine synthase
GPW66_RS05950	COG0175	sulfate reduction
GPW66_RS05955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPW66_RS05960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW66_RS05985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW66_RS05990	COG0735	belongs to the Fur family
GPW66_RS06005	COG0166	Belongs to the GPI family
GPW66_RS06010	COG0432	Pfam Uncharacterised protein family UPF0047
GPW66_RS06015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW66_RS06020	COG0305	Participates in initiation and elongation during chromosome replication
GPW66_RS06030	COG0359	binds to the 23S rRNA
GPW66_RS06035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPW66_RS06040	COG2965	DNA replication, synthesis of RNA primer
GPW66_RS06045	COG0360	Binds together with S18 to 16S ribosomal RNA
GPW66_RS06055	COG2906	2 iron, 2 sulfur cluster binding
GPW66_RS06060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW66_RS06065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW66_RS06070	COG0049	tRNA binding
GPW66_RS06075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPW66_RS06085	COG2923	Belongs to the DsrF TusC family
GPW66_RS06090	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPW66_RS06095	COG2964	Protein conserved in bacteria
GPW66_RS06100	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW66_RS06110	COG2900	Belongs to the SlyX family
GPW66_RS06115	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPW66_RS06120	COG0330	HflC and HflK could
GPW66_RS06125	COG0330	HflC and HflK could
GPW66_RS06130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPW66_RS06135	COG1923	regulation of RNA biosynthetic process
GPW66_RS06140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPW66_RS06145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPW66_RS06155	COG0802	atpase or kinase
GPW66_RS06160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPW66_RS06210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPW66_RS06215	COG1162	GTPase activity
GPW66_RS06220	COG0688	phosphatidylethanolamine metabolic process
GPW66_RS06225	COG0471	metal ion transport
GPW66_RS06235	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPW66_RS06240	COG4942	peptidase
GPW66_RS06255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPW66_RS06260	COG2816	NAD+ diphosphatase activity
GPW66_RS06265	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPW66_RS06270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPW66_RS06275	COG0085	RNA polymerase activity
GPW66_RS06280	COG0222	ribosome binding
GPW66_RS06285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPW66_RS06290	COG0081	regulation of translation
GPW66_RS06295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPW66_RS06300	COG0250	Participates in transcription elongation, termination and antitermination
GPW66_RS06305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW66_RS06310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW66_RS06335	COG1072	(Pantothenic acid kinase))
GPW66_RS06345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPW66_RS06355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPW66_RS06395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPW66_RS06405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPW66_RS06410	COG3118	belongs to the thioredoxin family
GPW66_RS06415	COG0513	Belongs to the DEAD box helicase family
GPW66_RS06420	COG0248	Ppx GppA phosphatase
GPW66_RS06425	COG2205	protein histidine kinase activity
GPW66_RS06425	COG2202	Pas domain
GPW66_RS06430	COG2814	Major facilitator Superfamily
GPW66_RS06450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW66_RS06455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPW66_RS06460	COG0511	ligase activity, forming carbon-carbon bonds
GPW66_RS06465	COG0439	Biotin carboxylase
GPW66_RS06475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW66_RS06480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPW66_RS06490	COG1609	Transcriptional regulator
GPW66_RS06495	COG0129	dihydroxy-acid dehydratase activity
GPW66_RS06500	COG3265	gluconokinase activity
GPW66_RS06510	COG0800	Aldolase
GPW66_RS06530	COG0840	transmembrane signaling receptor activity
GPW66_RS06535	COG1982	Orn Lys Arg decarboxylase major
GPW66_RS06540	COG0531	amino acid
GPW66_RS06545	COG3710	Transcriptional regulator
GPW66_RS06550	COG0789	Transcriptional regulator
GPW66_RS06560	COG0138	bifunctional purine biosynthesis protein purh
GPW66_RS06565	COG0151	Belongs to the GarS family
GPW66_RS06570	COG3385	transposase activity
GPW66_RS06580	COG0776	regulation of translation
GPW66_RS06585	COG1253	flavin adenine dinucleotide binding
GPW66_RS06595	COG3385	transposase activity
GPW66_RS06605	COG0668	transmembrane transport
GPW66_RS06610	COG1573	uracil-dna glycosylase
GPW66_RS06620	COG3068	Protein conserved in bacteria
GPW66_RS06630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPW66_RS06655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW66_RS06665	COG0438	transferase activity, transferring glycosyl groups
GPW66_RS06685	COG0367	asparagine synthase
GPW66_RS06690	COG1215	transferase activity, transferring glycosyl groups
GPW66_RS06710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW66_RS06715	COG1132	(ABC) transporter
GPW66_RS06725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW66_RS06735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPW66_RS06775	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW66_RS06785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW66_RS06810	COG0859	PFAM glycosyl transferase family 9
GPW66_RS06820	COG1519	Transferase
GPW66_RS06850	COG2755	lipolytic protein G-D-S-L family
GPW66_RS06850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GPW66_RS06855	COG3642	lipopolysaccharide core region biosynthetic process
GPW66_RS06860	COG0859	PFAM glycosyl transferase family 9
GPW66_RS06865	COG0463	Glycosyl transferase, family 2
GPW66_RS06870	COG0859	PFAM glycosyl transferase family 9
GPW66_RS06875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPW66_RS06880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPW66_RS06890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPW66_RS06895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPW66_RS06910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPW66_RS06920	COG1309	transcriptional regulator
GPW66_RS06925	COG1560	Kdo2-lipid A biosynthetic process
GPW66_RS06930	COG1560	Kdo2-lipid A biosynthetic process
GPW66_RS06935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPW66_RS06940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPW66_RS06945	COG1561	YicC-like family, N-terminal region
GPW66_RS06955	COG1263	PTS System
GPW66_RS06955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW66_RS06960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW66_RS06985	COG1120	ATPase activity
GPW66_RS06990	COG4774	siderophore transport
GPW66_RS06995	COG1132	(ABC) transporter
GPW66_RS07010	COG0514	ATP-dependent DNA helicase (RecQ)
GPW66_RS07015	COG2962	Rard protein
GPW66_RS07020	COG0405	Gamma-glutamyltransferase
GPW66_RS07030	COG1280	lysine exporter protein (LysE YggA)
GPW66_RS07035	COG0210	DNA helicase
GPW66_RS07045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPW66_RS07050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW66_RS07060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW66_RS07070	COG0747	negative chemotaxis
GPW66_RS07125	COG1309	transcriptional regulator
GPW66_RS07130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW66_RS07135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW66_RS07140	COG2960	long-chain fatty acid transporting porin activity
GPW66_RS07145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPW66_RS07150	COG0583	DNA-binding transcription factor activity
GPW66_RS07220	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPW66_RS07225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW66_RS07230	COG1739	Uncharacterized protein family UPF0029
GPW66_RS07235	COG1024	Enoyl-CoA hydratase
GPW66_RS07235	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW66_RS07240	COG0183	Belongs to the thiolase family
GPW66_RS07245	COG0583	DNA-binding transcription factor activity
GPW66_RS07250	COG2814	Major facilitator Superfamily
GPW66_RS07260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPW66_RS07265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPW66_RS07270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPW66_RS07275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPW66_RS07280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPW66_RS07285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPW66_RS07295	COG0356	it plays a direct role in the translocation of protons across the membrane
GPW66_RS07300	COG3312	ion transport
GPW66_RS07305	COG1475	DNA binding
GPW66_RS07310	COG1192	Involved in chromosome partitioning
GPW66_RS07315	COG0357	Ribosomal RNA small subunit methyltransferase G
GPW66_RS07320	COG0445	tRNA wobble uridine modification
GPW66_RS07330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW66_RS07335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPW66_RS07340	COG0706	membrane insertase activity
GPW66_RS07345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPW66_RS07350	COG0594	ribonuclease P activity
GPW66_RS07355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPW66_RS07360	COG1126	abc transporter atp-binding protein
GPW66_RS07375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPW66_RS07380	COG0592	DNA-directed DNA polymerase activity
GPW66_RS07385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPW66_RS07390	COG0187	DNA topoisomerase II activity
GPW66_RS07405	COG0071	Belongs to the small heat shock protein (HSP20) family
GPW66_RS07410	COG3977	Valine--pyruvate aminotransferase
GPW66_RS07415	COG0751	glycine-tRNA ligase activity
GPW66_RS07420	COG0752	glycyl-tRNA synthetase alpha subunit
GPW66_RS07425	COG2119	membrane
GPW66_RS07435	COG0425	Belongs to the sulfur carrier protein TusA family
GPW66_RS07445	COG0604	alcohol dehydrogenase
GPW66_RS07455	COG0129	dihydroxy-acid dehydratase activity
GPW66_RS07460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW66_RS07475	COG0606	chelatase, subunit chli
GPW66_RS07480	COG0204	Acyl-transferase
GPW66_RS07485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW66_RS07490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPW66_RS07500	COG3084	Protein conserved in bacteria
GPW66_RS07505	COG3385	transposase activity
GPW66_RS07515	COG4326	sporulation control protein
GPW66_RS07520	COG1272	protein, Hemolysin III
GPW66_RS07530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW66_RS07535	COG0569	domain protein
GPW66_RS07540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW66_RS07540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW66_RS07545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW66_RS07550	COG0242	peptide deformylase activity
GPW66_RS07555	COG1652	LysM domain
GPW66_RS07560	COG0758	DNA mediated transformation
GPW66_RS07565	COG2922	Belongs to the Smg family
GPW66_RS07570	COG0551	DNA topoisomerase type I activity
GPW66_RS07575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPW66_RS07580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPW66_RS07585	COG0009	L-threonylcarbamoyladenylate synthase
GPW66_RS07590	COG0408	coproporphyrinogen oxidase activity
GPW66_RS07595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPW66_RS07605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPW66_RS07645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPW66_RS07650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPW66_RS07660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW66_RS07665	COG2104	thiamine diphosphate biosynthetic process
GPW66_RS07670	COG2022	thiamine diphosphate biosynthetic process
GPW66_RS07675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW66_RS07680	COG0006	proline dipeptidase activity
GPW66_RS07700	COG1522	sequence-specific DNA binding
GPW66_RS07705	COG5001	Diguanylate cyclase
GPW66_RS07705	COG5002	protein histidine kinase activity
GPW66_RS07710	COG0742	ribosomal rna small subunit methyltransferase
GPW66_RS07720	COG0697	spore germination
GPW66_RS07725	COG0589	response to stress
GPW66_RS07735	COG1528	Iron-storage protein
GPW66_RS07745	COG2081	HI0933 family
GPW66_RS07755	COG1322	Protein conserved in bacteria
GPW66_RS07760	COG2226	methyltransferase
GPW66_RS07770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPW66_RS07775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW66_RS07780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW66_RS07785	COG0805	protein transport
GPW66_RS07790	COG1858	cytochrome C peroxidase
GPW66_RS07795	COG0534	Mate efflux family protein
GPW66_RS07805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPW66_RS07810	COG2937	Belongs to the GPAT DAPAT family
GPW66_RS07815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPW66_RS07820	COG3161	chorismate lyase activity
GPW66_RS07830	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW66_RS07835	COG0840	transmembrane signaling receptor activity
GPW66_RS07845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW66_RS07850	COG0084	hydrolase, TatD family'
GPW66_RS07870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW66_RS07870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW66_RS07875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPW66_RS07890	COG3078	GTPase activator activity
GPW66_RS07900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW66_RS07905	COG3071	HemY protein
GPW66_RS07910	COG2959	enzyme of heme biosynthesis
GPW66_RS07915	COG1587	Uroporphyrinogen-III synthase
GPW66_RS07920	COG0181	hydroxymethylbilane synthase activity
GPW66_RS07930	COG3072	Adenylate cyclase
GPW66_RS07935	COG1965	Belongs to the frataxin family
GPW66_RS07945	COG0019	diaminopimelate decarboxylase activity
GPW66_RS07950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPW66_RS07960	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPW66_RS07965	COG1011	Hydrolase
GPW66_RS07970	COG3287	FIST C domain
GPW66_RS07970	COG2200	EAL domain
GPW66_RS07970	COG2199	diguanylate cyclase activity
GPW66_RS07985	COG0561	phosphatase activity
GPW66_RS07990	COG2267	carboxylic ester hydrolase activity
GPW66_RS07995	COG1280	lysine exporter protein (LysE YggA)
GPW66_RS08000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW66_RS08005	COG0783	Belongs to the Dps family
GPW66_RS08035	COG0742	ribosomal rna small subunit methyltransferase
GPW66_RS08040	COG0552	protein localization to endoplasmic reticulum
GPW66_RS08045	COG2884	Cell division ATP-binding protein ftsE
GPW66_RS08050	COG2177	Part of the ABC transporter FtsEX involved in
GPW66_RS08055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW66_RS08060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW66_RS08075	COG3385	transposase activity
GPW66_RS08110	COG0328	RNA-DNA hybrid ribonuclease activity
GPW66_RS08165	COG2003	Belongs to the UPF0758 family
GPW66_RS08190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW66_RS08205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPW66_RS08280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPW66_RS08285	COG3300	MHYT domain
GPW66_RS08285	COG5001	Diguanylate cyclase
GPW66_RS08295	COG3852	Histidine kinase
GPW66_RS08305	COG0174	glutamine synthetase
GPW66_RS08320	COG1660	Displays ATPase and GTPase activities
GPW66_RS08330	COG1490	D-aminoacyl-tRNA deacylase activity
GPW66_RS08335	COG0456	acetyltransferase
GPW66_RS08345	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPW66_RS08350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPW66_RS08355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPW66_RS08360	COG3031	protein transport across the cell outer membrane
GPW66_RS08370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW66_RS08375	COG1459	type II secretion system
GPW66_RS08380	COG2165	general secretion pathway protein
GPW66_RS08385	COG2165	general secretion pathway protein
GPW66_RS08390	COG2165	general secretion pathway protein
GPW66_RS08395	COG4795	General secretion pathway protein
GPW66_RS08400	COG3156	type II secretion system protein K
GPW66_RS08405	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW66_RS08410	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW66_RS08420	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPW66_RS08425	COG0494	nUDIX hydrolase
GPW66_RS08430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPW66_RS08430	COG0316	Belongs to the HesB IscA family
GPW66_RS08435	COG1040	competence protein
GPW66_RS08440	COG0596	Alpha beta hydrolase
GPW66_RS08450	COG2183	response to ionizing radiation
GPW66_RS08455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW66_RS08460	COG2199	diguanylate cyclase activity
GPW66_RS08465	COG0745	RESPONSE REGULATOR receiver
GPW66_RS08475	COG2233	PERMEase
GPW66_RS08480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPW66_RS08485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW66_RS08490	COG1758	RNA polymerase activity
GPW66_RS08495	COG0194	GDP metabolic process
GPW66_RS08500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPW66_RS08505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW66_RS08515	COG3263	regulation of cellular component size
GPW66_RS08525	COG4232	protein-disulfide reductase activity
GPW66_RS08540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW66_RS08545	COG1027	Aspartate ammonia-lyase
GPW66_RS08550	COG3706	GGDEF domain
GPW66_RS08555	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPW66_RS08560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPW66_RS08570	COG2205	protein histidine kinase activity
GPW66_RS08575	COG0745	RESPONSE REGULATOR receiver
GPW66_RS08585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPW66_RS08590	COG0205	6-phosphofructokinase activity
GPW66_RS08595	COG1494	fructose-1,6-bisphosphatase
GPW66_RS08600	COG3074	FtsZ-dependent cytokinesis
GPW66_RS08605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPW66_RS08610	COG0460	homoserine dehydrogenase
GPW66_RS08610	COG0527	aspartate kinase activity
GPW66_RS08615	COG0626	cystathionine gamma-synthase activity
GPW66_RS08620	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPW66_RS08625	COG0281	malic enzyme
GPW66_RS08630	COG0254	rRNA binding
GPW66_RS08635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPW66_RS08640	COG1609	Transcriptional regulator
GPW66_RS08645	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW66_RS08650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPW66_RS08655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPW66_RS08660	COG1575	Belongs to the MenA family. Type 1 subfamily
GPW66_RS08665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW66_RS08675	COG0149	triose-phosphate isomerase activity
GPW66_RS08700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW66_RS08705	COG0459	protein refolding
GPW66_RS08715	COG1509	lysine 2,3-aminomutase activity
GPW66_RS08720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW66_RS08725	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW66_RS08730	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW66_RS08735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPW66_RS08740	COG1053	succinate dehydrogenase
GPW66_RS08745	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPW66_RS08750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW66_RS08755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPW66_RS08760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPW66_RS08765	COG1045	serine acetyltransferase
GPW66_RS08775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPW66_RS08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW66_RS08785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPW66_RS08790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW66_RS08795	COG0137	argininosuccinate synthase activity
GPW66_RS08800	COG0165	Argininosuccinate lyase
GPW66_RS08810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW66_RS08815	COG0678	peroxiredoxin activity
GPW66_RS08815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW66_RS08825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPW66_RS08855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPW66_RS08860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPW66_RS08870	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPW66_RS08875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPW66_RS08880	COG0546	phosphoglycolate phosphatase activity
GPW66_RS08885	COG0180	Tryptophanyl-tRNA synthetase
GPW66_RS08900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW66_RS08910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPW66_RS08930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW66_RS08935	COG3954	Phosphoribulokinase
GPW66_RS08945	COG0429	hydrolase of the alpha beta-hydrolase fold
GPW66_RS08955	COG0488	(ABC) transporter
GPW66_RS08960	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPW66_RS08975	COG1047	Peptidyl-prolyl cis-trans
GPW66_RS08985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPW66_RS08990	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPW66_RS08995	COG3083	sulfuric ester hydrolase activity
GPW66_RS09000	COG0557	exoribonuclease II activity
GPW66_RS09005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW66_RS09010	COG0051	transcription antitermination factor activity, RNA binding
GPW66_RS09015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPW66_RS09020	COG0088	Forms part of the polypeptide exit tunnel
GPW66_RS09025	COG0089	rRNA binding
GPW66_RS09030	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPW66_RS09035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPW66_RS09040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPW66_RS09045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPW66_RS09050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPW66_RS09055	COG0255	Belongs to the universal ribosomal protein uL29 family
GPW66_RS09060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPW66_RS09065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPW66_RS09070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPW66_RS09075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPW66_RS09080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPW66_RS09085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPW66_RS09090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPW66_RS09095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPW66_RS09100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPW66_RS09105	COG1841	ribosomal large subunit assembly
GPW66_RS09110	COG0200	Binds to the 23S rRNA
GPW66_RS09115	COG0201	protein transport
GPW66_RS09125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPW66_RS09130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPW66_RS09135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPW66_RS09140	COG0202	RNA polymerase activity
GPW66_RS09145	COG0203	ribosomal protein L17
GPW66_RS09155	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW66_RS09160	COG3266	domain, Protein
GPW66_RS09160	COG3061	Opacity-associated protein A
GPW66_RS09165	COG0697	spore germination
GPW66_RS09170	COG2153	protein acetylation
GPW66_RS09175	COG0513	Belongs to the DEAD box helicase family
GPW66_RS09185	COG0737	Belongs to the 5'-nucleotidase family
GPW66_RS09190	COG1648	precorrin-2 dehydrogenase activity
GPW66_RS09190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPW66_RS09195	COG0175	sulfate reduction
GPW66_RS09200	COG2895	sulfate adenylyltransferase (ATP) activity
GPW66_RS09205	COG0529	Catalyzes the synthesis of activated sulfate
GPW66_RS09225	COG1136	(ABC) transporter
GPW66_RS09240	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPW66_RS09245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW66_RS09250	COG0729	surface antigen
GPW66_RS09260	COG2105	PFAM AIG2 family protein
GPW66_RS09265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPW66_RS09270	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPW66_RS09275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW66_RS09280	COG0163	prenyltransferase activity
GPW66_RS09285	COG4143	(ABC) transporter
GPW66_RS09290	COG1178	ABC-type Fe3 transport system permease component
GPW66_RS09295	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPW66_RS09300	COG3028	Belongs to the UPF0307 family
GPW66_RS09305	COG0312	modulator of DNA gyrase
GPW66_RS09310	COG2239	Acts as a magnesium transporter
GPW66_RS09315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW66_RS09325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW66_RS09330	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW66_RS09340	COG1137	ATPase activity
GPW66_RS09345	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPW66_RS09360	COG0517	IMP dehydrogenase activity
GPW66_RS09360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPW66_RS09370	COG1127	ABC transporter
GPW66_RS09375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPW66_RS09380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW66_RS09385	COG2854	intermembrane phospholipid transfer
GPW66_RS09395	COG5007	Belongs to the BolA IbaG family
GPW66_RS09400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPW66_RS09405	COG0204	Acyl-transferase
GPW66_RS09410	COG0251	oxidation-reduction process
GPW66_RS09415	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPW66_RS09420	COG0540	Belongs to the ATCase OTCase family
GPW66_RS09425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPW66_RS09430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPW66_RS09435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPW66_RS09440	COG0564	pseudouridine synthase activity
GPW66_RS09445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW66_RS09450	COG4269	membrane
GPW66_RS09460	COG0525	valine-tRNA ligase activity
GPW66_RS09465	COG2927	DNA polymerase III (CHI subunit)
GPW66_RS09470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW66_RS09475	COG0795	lipopolysaccharide-transporting ATPase activity
GPW66_RS09480	COG0795	lipopolysaccharide-transporting ATPase activity
GPW66_RS09500	COG3437	response regulator, receiver
GPW66_RS09545	COG0066	3-isopropylmalate dehydratase activity
GPW66_RS09550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPW66_RS09555	COG0473	3-isopropylmalate dehydrogenase activity
GPW66_RS09560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW66_RS09580	COG0583	DNA-binding transcription factor activity
GPW66_RS09585	COG1022	Amp-dependent synthetase and ligase
GPW66_RS09590	COG0028	Belongs to the TPP enzyme family
GPW66_RS09595	COG0440	acetolactate synthase activity
GPW66_RS09600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW66_RS09605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPW66_RS09610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPW66_RS09620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPW66_RS09630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW66_RS09635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW66_RS09650	COG0354	folic acid binding
GPW66_RS09655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPW66_RS09665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPW66_RS09670	COG1595	DNA-templated transcription, initiation
GPW66_RS09675	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPW66_RS09680	COG3026	antisigma factor binding
GPW66_RS09685	COG3086	response to oxidative stress
GPW66_RS09690	COG0481	GTPase activity
GPW66_RS09695	COG0681	Belongs to the peptidase S26 family
GPW66_RS09700	COG0571	ribonuclease III activity
GPW66_RS09705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPW66_RS09710	COG1381	Involved in DNA repair and RecF pathway recombination
GPW66_RS09715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPW66_RS09720	COG0736	holo-[acyl-carrier-protein] synthase activity
GPW66_RS09745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW66_RS09750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW66_RS09755	COG3956	TIGRFAM MazG family protein
GPW66_RS09760	COG0504	CTP synthase activity
GPW66_RS09765	COG0148	phosphopyruvate hydratase activity
GPW66_RS09770	COG0617	tRNA 3'-terminal CCA addition
GPW66_RS09775	COG3409	Peptidoglycan-binding domain 1 protein
GPW66_RS09775	COG3267	Type II secretory pathway component ExeA
GPW66_RS09785	COG4991	sh3 domain protein
GPW66_RS09790	COG0306	phosphate transporter
GPW66_RS09795	COG1392	Phosphate transport regulator
GPW66_RS09800	COG3025	triphosphatase activity
GPW66_RS09810	COG0840	transmembrane signaling receptor activity
GPW66_RS09815	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPW66_RS09825	COG1538	Outer membrane efflux protein
GPW66_RS09830	COG0494	nUDIX hydrolase
GPW66_RS09835	COG3151	Protein conserved in bacteria
GPW66_RS09845	COG3150	esterase
GPW66_RS09850	COG0187	DNA topoisomerase II activity
GPW66_RS09855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPW66_RS09860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPW66_RS09865	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPW66_RS09870	COG0237	dephospho-CoA kinase activity
GPW66_RS09880	COG1459	type II secretion system
GPW66_RS09885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW66_RS09895	COG0157	Belongs to the NadC ModD family
GPW66_RS09905	COG0716	FMN binding
GPW66_RS09910	COG4974	Belongs to the 'phage' integrase family
GPW66_RS09915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW66_RS09920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPW66_RS09925	COG2186	Transcriptional regulator
GPW66_RS09930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPW66_RS09935	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW66_RS09940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW66_RS09950	COG0275	rRNA processing
GPW66_RS09955	COG3116	cell division
GPW66_RS09960	COG0768	penicillin binding
GPW66_RS09965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPW66_RS09970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPW66_RS09975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPW66_RS09980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPW66_RS09985	COG0772	Belongs to the SEDS family
GPW66_RS09990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPW66_RS09995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW66_RS10000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPW66_RS10005	COG0849	cell division
GPW66_RS10010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPW66_RS10015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPW66_RS10025	COG0653	protein targeting
GPW66_RS10030	COG0494	nUDIX hydrolase
GPW66_RS10035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPW66_RS10045	COG0505	Belongs to the CarA family
GPW66_RS10050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPW66_RS10055	COG0730	response to heat
GPW66_RS10060	COG0583	DNA-binding transcription factor activity
GPW66_RS10065	COG2860	membrane
GPW66_RS10070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPW66_RS10080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPW66_RS10090	COG0493	'glutamate synthase
GPW66_RS10095	COG0070	glutamate synthase
GPW66_RS10095	COG0069	glutamate synthase activity
GPW66_RS10095	COG0067	glutamate synthase
GPW66_RS10105	COG0070	glutamate synthase
GPW66_RS10105	COG0069	glutamate synthase activity
GPW66_RS10105	COG0067	glutamate synthase
GPW66_RS10110	COG1242	4 iron, 4 sulfur cluster binding
GPW66_RS10115	COG5001	Diguanylate cyclase
GPW66_RS10115	COG4251	negative regulation of phosphorylation
GPW66_RS10115	COG3706	GGDEF domain
GPW66_RS10115	COG2203	Gaf domain
GPW66_RS10120	COG0784	Response regulator, receiver
GPW66_RS10120	COG2198	Histidine kinase
GPW66_RS10120	COG5002	protein histidine kinase activity
GPW66_RS10125	COG0745	RESPONSE REGULATOR receiver
GPW66_RS10135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW66_RS10155	COG0083	homoserine kinase activity
GPW66_RS10160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPW66_RS10165	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPW66_RS10170	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPW66_RS10175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPW66_RS10190	COG1115	amino acid carrier protein
GPW66_RS10205	COG0084	hydrolase, TatD family'
GPW66_RS10210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW66_RS10220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPW66_RS10225	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPW66_RS10230	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPW66_RS10235	COG0813	purine-nucleoside phosphorylase activity
GPW66_RS10240	COG3385	transposase activity
GPW66_RS10250	COG0560	Phosphoserine phosphatase
GPW66_RS10260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPW66_RS10265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW66_RS10270	COG1022	Amp-dependent synthetase and ligase
GPW66_RS10285	COG3250	beta-galactosidase activity
GPW66_RS10290	COG1609	Transcriptional regulator
GPW66_RS10295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW66_RS10310	COG0189	ligase activity
GPW66_RS10310	COG0569	domain protein
GPW66_RS10315	COG0456	acetyltransferase
GPW66_RS10325	COG2171	N-acyltransferase activity
GPW66_RS10330	COG3141	response to X-ray
GPW66_RS10345	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPW66_RS10350	COG1074	ATP-dependent DNA helicase activity
GPW66_RS10355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPW66_RS10365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW66_RS10365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPW66_RS10375	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPW66_RS10380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPW66_RS10385	COG2166	iron-sulfur cluster assembly
GPW66_RS10390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW66_RS10395	COG0693	protein deglycase activity
GPW66_RS10400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPW66_RS10415	COG1595	DNA-templated transcription, initiation
GPW66_RS10425	COG2211	Major facilitator Superfamily
GPW66_RS10430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW66_RS10440	COG2813	Specifically methylates the guanine in position
GPW66_RS10445	COG0271	Belongs to the BolA IbaG family
GPW66_RS10450	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW66_RS10455	COG1805	sodium ion transport
GPW66_RS10460	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW66_RS10465	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW66_RS10470	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW66_RS10475	COG2871	sodium ion transport
GPW66_RS10480	COG1477	protein flavinylation
GPW66_RS10490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPW66_RS10500	COG3706	GGDEF domain
GPW66_RS10505	COG0733	neurotransmitter:sodium symporter activity
GPW66_RS10510	COG3385	transposase activity
GPW66_RS10520	COG0189	ligase activity
GPW66_RS10525	COG0189	ligase activity
GPW66_RS10525	COG4067	protein conserved in archaea
GPW66_RS10530	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW66_RS10535	COG2252	PERMEase
GPW66_RS10540	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPW66_RS10555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPW66_RS10560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPW66_RS10565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPW66_RS10570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW66_RS10570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW66_RS10585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPW66_RS10590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW66_RS10595	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPW66_RS10600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPW66_RS10610	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPW66_RS10615	COG0024	Methionine aminopeptidase
GPW66_RS10620	COG0052	Belongs to the universal ribosomal protein uS2 family
GPW66_RS10625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPW66_RS10630	COG0528	UMP kinase activity
GPW66_RS10635	COG0233	cytoplasmic translational termination
GPW66_RS10640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPW66_RS10645	COG0575	Belongs to the CDS family
GPW66_RS10650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPW66_RS10655	COG0750	zinc metalloprotease
GPW66_RS10665	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPW66_RS10670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW66_RS10675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW66_RS10680	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW66_RS10685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW66_RS10690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPW66_RS10695	COG0587	DNA-directed DNA polymerase activity
GPW66_RS10700	COG0825	malonyl-CoA metabolic process
GPW66_RS10710	COG3385	transposase activity
GPW66_RS10720	COG0037	tRNA processing
GPW66_RS10730	COG3479	Phenolic acid decarboxylase
GPW66_RS10735	COG0347	Belongs to the P(II) protein family
GPW66_RS10745	COG0741	lytic transglycosylase activity
GPW66_RS10745	COG1388	LysM domain
GPW66_RS10750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW66_RS10755	COG2226	methyltransferase
GPW66_RS10760	COG0328	RNA-DNA hybrid ribonuclease activity
GPW66_RS10765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW66_RS10775	COG1960	acyl-CoA dehydrogenase activity
GPW66_RS10780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW66_RS10785	COG0121	glutamine amidotransferase
GPW66_RS10790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPW66_RS10795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPW66_RS10800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPW66_RS10805	COG3706	GGDEF domain
GPW66_RS10810	COG1187	pseudouridine synthase activity
GPW66_RS10815	COG2840	Smr protein MutS2
GPW66_RS10845	COG2217	Heavy metal translocating P-type atpase
GPW66_RS10845	COG2608	mercury ion transmembrane transporter activity
GPW66_RS10850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW66_RS10865	COG1629	transport
GPW66_RS10865	COG4774	siderophore transport
GPW66_RS10870	COG2375	cellular response to nickel ion
GPW66_RS10875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPW66_RS10875	COG3433	isochorismatase activity
GPW66_RS10875	COG2226	methyltransferase
GPW66_RS10910	COG0835	chemotaxis
GPW66_RS10910	COG0784	Response regulator, receiver
GPW66_RS10915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW66_RS10920	COG1815	bacterial-type flagellum-dependent cell motility
GPW66_RS10925	COG1558	bacterial-type flagellum-dependent cell motility
GPW66_RS10930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPW66_RS10935	COG1749	Flagellar hook protein flgE
GPW66_RS10940	COG4787	bacterial-type flagellum-dependent cell motility
GPW66_RS10945	COG4786	Flagellar basal body rod
GPW66_RS10950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPW66_RS10955	COG1706	bacterial-type flagellum-dependent cell motility
GPW66_RS10960	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPW66_RS10960	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPW66_RS10975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW66_RS10980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW66_RS11065	COG0012	GTP binding
GPW66_RS11070	COG0193	aminoacyl-tRNA hydrolase activity
GPW66_RS11075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPW66_RS11080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPW66_RS11085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPW66_RS11090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPW66_RS11095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPW66_RS11100	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW66_RS11105	COG3094	Invasion gene expression up-regulator, SirB
GPW66_RS11110	COG2912	Transglutaminase-like superfamily
GPW66_RS11115	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPW66_RS11120	COG0737	Belongs to the 5'-nucleotidase family
GPW66_RS11125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPW66_RS11130	COG2233	PERMEase
GPW66_RS11150	COG1393	Belongs to the ArsC family
GPW66_RS11155	COG4783	chaperone-mediated protein folding
GPW66_RS11175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPW66_RS11185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW66_RS11190	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPW66_RS11205	COG1876	peptidase activity
GPW66_RS11210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW66_RS11215	COG1393	Belongs to the ArsC family
GPW66_RS11235	COG2837	iron assimilation
GPW66_RS11240	COG3385	transposase activity
GPW66_RS11245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW66_RS11250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW66_RS11255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW66_RS11260	COG1334	flagellar protein FlaG
GPW66_RS11265	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPW66_RS11275	COG1516	flagellar protein fliS
GPW66_RS11280	COG2204	response regulator
GPW66_RS11285	COG4191	Histidine kinase
GPW66_RS11290	COG2204	response regulator
GPW66_RS11295	COG1677	Flagellar hook-basal body complex protein FliE
GPW66_RS11305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPW66_RS11310	COG1317	bacterial-type flagellum organization
GPW66_RS11335	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW66_RS11360	COG1987	bacterial-type flagellum assembly
GPW66_RS11365	COG1684	flagellar biosynthetic protein fliR
GPW66_RS11380	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW66_RS11385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPW66_RS11390	COG2860	membrane
GPW66_RS11395	COG3101	peptidyl-lysine hydroxylation
GPW66_RS11405	COG0431	NADPH-dependent FMN reductase
GPW66_RS11410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW66_RS11410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPW66_RS11415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW66_RS11420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW66_RS11425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW66_RS11430	COG3385	transposase activity
GPW66_RS11435	COG0735	belongs to the Fur family
GPW66_RS11445	COG0583	DNA-binding transcription factor activity
GPW66_RS11450	COG1380	Effector of murein hydrolase LrgA
GPW66_RS11455	COG1346	cytolysis
GPW66_RS11470	COG0596	Alpha beta hydrolase
GPW66_RS11475	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPW66_RS11480	COG0033	Phosphoglucomutase
GPW66_RS11490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPW66_RS11495	COG0372	Belongs to the citrate synthase family
GPW66_RS11500	COG2009	succinate dehydrogenase
GPW66_RS11505	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPW66_RS11510	COG1053	succinate dehydrogenase
GPW66_RS11520	COG0567	Dehydrogenase, E1 component
GPW66_RS11525	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW66_RS11530	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW66_RS11540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPW66_RS11545	COG1121	(ABC) transporter
GPW66_RS11550	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPW66_RS11555	COG4977	sequence-specific DNA binding
GPW66_RS11560	COG1918	ferrous iron import across plasma membrane
GPW66_RS11580	COG0018	arginyl-trna synthetase
GPW66_RS11590	COG1025	Belongs to the peptidase M16 family
GPW66_RS11595	COG2062	phosphohistidine phosphatase, SixA
GPW66_RS11610	COG0455	bacterial-type flagellum organization
GPW66_RS11625	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPW66_RS11630	COG2198	Histidine kinase
GPW66_RS11630	COG0643	Histidine kinase
GPW66_RS11635	COG2201	protein-glutamate methylesterase activity
GPW66_RS11640	COG1192	Involved in chromosome partitioning
GPW66_RS11650	COG0835	chemotaxis
GPW66_RS11660	COG4133	protoheme IX ABC transporter activity
GPW66_RS11665	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW66_RS11670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW66_RS11680	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPW66_RS11685	COG1138	Cytochrome C-type biogenesis protein
GPW66_RS11690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPW66_RS11695	COG4235	cytochrome complex assembly
GPW66_RS11695	COG3088	subunit of a heme lyase
GPW66_RS11705	COG2853	Lipoprotein
GPW66_RS11725	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPW66_RS11730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW66_RS11735	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPW66_RS11750	COG3083	sulfuric ester hydrolase activity
GPW66_RS11760	COG3081	Nucleoid-associated protein
GPW66_RS11770	COG1757	Na H antiporter
GPW66_RS11775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW66_RS11780	COG2095	MarC family integral membrane protein
GPW66_RS11785	COG1454	alcohol dehydrogenase
GPW66_RS11785	COG1012	belongs to the aldehyde dehydrogenase family
GPW66_RS11795	COG0659	secondary active sulfate transmembrane transporter activity
GPW66_RS11800	COG1530	ribonuclease E activity
GPW66_RS11805	COG0564	pseudouridine synthase activity
GPW66_RS11810	COG0424	maF-like protein
GPW66_RS11815	COG1399	metal-binding, possibly nucleic acid-binding protein
GPW66_RS11820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPW66_RS11825	COG0416	fatty acid biosynthetic process
GPW66_RS11830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW66_RS11835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPW66_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
GPW66_RS11845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPW66_RS11850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW66_RS11855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW66_RS11860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPW66_RS11865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPW66_RS11875	COG0084	hydrolase, TatD family'
GPW66_RS11880	COG1263	PTS System
GPW66_RS11880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW66_RS11890	COG0733	neurotransmitter:sodium symporter activity
GPW66_RS11905	COG4667	esterase of the alpha-beta hydrolase superfamily
GPW66_RS11915	COG1940	carbohydrate kinase activity
GPW66_RS11920	COG0784	Response regulator, receiver
GPW66_RS11920	COG0835	chemotaxis
GPW66_RS11935	COG2226	methyltransferase
GPW66_RS11945	COG0676	glucose-6-phosphate 1-epimerase activity
GPW66_RS11950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW66_RS11955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW66_RS11965	COG3139	Protein of unknown function (DUF1315)
GPW66_RS11970	COG0252	asparaginase activity
GPW66_RS11975	COG0616	signal peptide processing
GPW66_RS11980	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW66_RS11980	COG1902	pentaerythritol trinitrate reductase activity
GPW66_RS11985	COG0788	formyltetrahydrofolate deformylase activity
GPW66_RS11995	COG1199	ATP-dependent helicase activity
GPW66_RS12000	COG1214	PFAM Peptidase M22, glycoprotease
GPW66_RS12015	COG2267	carboxylic ester hydrolase activity
GPW66_RS12020	COG0318	PFAM AMP-dependent synthetase and ligase
GPW66_RS12025	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPW66_RS12040	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPW66_RS12045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPW66_RS12050	COG0436	Aminotransferase
GPW66_RS12055	COG1169	isochorismate synthase
GPW66_RS12060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPW66_RS12065	COG0596	Alpha beta hydrolase
GPW66_RS12075	COG1441	menaquinone biosynthetic process
GPW66_RS12085	COG3135	benzoate transporter
GPW66_RS12110	COG3015	lipoprotein NlpE involved in copper resistance
GPW66_RS12115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPW66_RS12120	COG2894	cell division
GPW66_RS12125	COG0850	regulation of cytokinetic process
GPW66_RS12130	COG3100	YcgL domain-containing protein
GPW66_RS12135	COG2951	lytic endotransglycosylase activity
GPW66_RS12145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW66_RS12150	COG3469	chitinase activity
GPW66_RS12150	COG3325	Belongs to the glycosyl hydrolase 18 family
GPW66_RS12155	COG3005	denitrification pathway
GPW66_RS12160	COG0243	molybdopterin cofactor binding
GPW66_RS12180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW66_RS12190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPW66_RS12225	COG4589	Belongs to the CDS family
GPW66_RS12235	COG3300	MHYT domain
GPW66_RS12235	COG5001	Diguanylate cyclase
GPW66_RS12250	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPW66_RS12255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW66_RS12260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW66_RS12265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW66_RS12275	COG4191	Histidine kinase
GPW66_RS12285	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPW66_RS12295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPW66_RS12300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPW66_RS12305	COG0776	regulation of translation
GPW66_RS12310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW66_RS12315	COG1555	photosystem II stabilization
GPW66_RS12320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPW66_RS12325	COG0539	negative regulation of cytoplasmic translation
GPW66_RS12330	COG0776	regulation of translation
GPW66_RS12335	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPW66_RS12340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPW66_RS12345	COG0284	orotidine-5'-phosphate decarboxylase activity
GPW66_RS12360	COG0583	DNA-binding transcription factor activity
GPW66_RS12370	COG0686	Belongs to the AlaDH PNT family
GPW66_RS12385	COG1674	ftsk spoiiie
GPW66_RS12390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPW66_RS12395	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW66_RS12400	COG2186	Transcriptional regulator
GPW66_RS12415	COG0537	adenosine 5'-monophosphoramidase activity
GPW66_RS12445	COG1252	NADH dehydrogenase
GPW66_RS12465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPW66_RS12475	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW66_RS12480	COG1136	(ABC) transporter
GPW66_RS12485	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW66_RS12500	COG2333	competence protein COMEC
GPW66_RS12500	COG0658	competence protein
GPW66_RS12505	COG1132	(ABC) transporter
GPW66_RS12510	COG1663	tetraacyldisaccharide 4'-kinase activity
GPW66_RS12520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPW66_RS12525	COG2719	SpoVR family
GPW66_RS12530	COG2718	Belongs to the UPF0229 family
GPW66_RS12535	COG2766	serine protein kinase
GPW66_RS12540	COG3013	Belongs to the UPF0304 family
GPW66_RS12550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPW66_RS12555	COG0840	transmembrane signaling receptor activity
GPW66_RS12565	COG1882	Formate acetyltransferase
GPW66_RS12585	COG4215	(ABC) transporter
GPW66_RS12590	COG4160	amino acid transport
GPW66_RS12595	COG0708	Exodeoxyribonuclease III
GPW66_RS12600	COG0840	transmembrane signaling receptor activity
GPW66_RS12610	COG3923	Primosomal replication protein n
GPW66_RS12615	COG0730	response to heat
GPW66_RS12620	COG1199	ATP-dependent helicase activity
GPW66_RS12625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW66_RS12630	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW66_RS12640	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW66_RS12645	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW66_RS12650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW66_RS12655	COG0215	cysteine-tRNA ligase activity
GPW66_RS12660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPW66_RS12665	COG0632	four-way junction helicase activity
GPW66_RS12670	COG2255	four-way junction helicase activity
GPW66_RS12675	COG1271	oxidase subunit
GPW66_RS12680	COG1294	oxidase, subunit
GPW66_RS12685	COG4890	Cyd operon protein YbgT
GPW66_RS12690	COG3790	cyd operon protein YbgE
GPW66_RS12695	COG0824	Thioesterase
GPW66_RS12700	COG0811	peptide transport
GPW66_RS12715	COG0823	Involved in the tonB-independent uptake of proteins
GPW66_RS12720	COG2885	chlorophyll binding
GPW66_RS12730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPW66_RS12740	COG5002	protein histidine kinase activity
GPW66_RS12740	COG0784	Response regulator, receiver
GPW66_RS12750	COG1482	cell wall glycoprotein biosynthetic process
GPW66_RS12755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW66_RS12755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW66_RS12755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW66_RS12760	COG2207	Transcriptional regulator
GPW66_RS12770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW66_RS12775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW66_RS12780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW66_RS12790	COG1012	belongs to the aldehyde dehydrogenase family
GPW66_RS12795	COG3284	Transcriptional regulator
GPW66_RS12800	COG4628	conserved protein (DUF2132)
GPW66_RS12810	COG0415	Belongs to the DNA photolyase family
GPW66_RS12830	COG4409	exo-alpha-(2->6)-sialidase activity
GPW66_RS12835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW66_RS12840	COG1940	carbohydrate kinase activity
GPW66_RS12845	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPW66_RS12855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW66_RS12860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW66_RS12865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW66_RS12870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW66_RS12875	COG1737	Transcriptional regulator
GPW66_RS12880	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW66_RS12885	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW66_RS12895	COG5492	domain, Protein
GPW66_RS12895	COG4932	domain protein
GPW66_RS12920	COG0596	Alpha beta hydrolase
GPW66_RS12930	COG3064	Membrane
GPW66_RS13035	COG4789	Type iii secretion
GPW66_RS13040	COG4792	protein secretion
GPW66_RS13080	COG4790	Type iii secretion
GPW66_RS13160	COG0582	viral genome integration into host DNA
GPW66_RS13215	COG2801	Transposase and inactivated derivatives
GPW66_RS13285	COG0740	serine-type endopeptidase activity
GPW66_RS13300	COG4626	Terminase
GPW66_RS13300	COG1802	Transcriptional regulator
GPW66_RS13335	COG3772	lysozyme
GPW66_RS13360	COG1403	HNH endonuclease
GPW66_RS13465	COG2974	May be involved in recombination
GPW66_RS13580	COG0582	viral genome integration into host DNA
GPW66_RS13595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW66_RS13605	COG3008	intermembrane lipid transfer
GPW66_RS13605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW66_RS13610	COG2995	paraquat-inducible protein a
GPW66_RS13615	COG0668	transmembrane transport
GPW66_RS13635	COG1309	transcriptional regulator
GPW66_RS13640	COG1012	belongs to the aldehyde dehydrogenase family
GPW66_RS13660	COG1960	acyl-CoA dehydrogenase activity
GPW66_RS13665	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW66_RS13670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPW66_RS13675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPW66_RS13680	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPW66_RS13690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPW66_RS13700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW66_RS13705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW66_RS13710	COG0297	glycogen (starch) synthase activity
GPW66_RS13730	COG3070	regulator of competence-specific genes
GPW66_RS13735	COG1609	Transcriptional regulator
GPW66_RS13745	COG0745	RESPONSE REGULATOR receiver
GPW66_RS13750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW66_RS13755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW66_RS13760	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPW66_RS13765	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPW66_RS13770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPW66_RS13775	COG1979	alcohol dehydrogenase
GPW66_RS13780	COG2207	Transcriptional regulator
GPW66_RS13805	COG1032	radical SAM domain protein
GPW66_RS13815	COG0612	Peptidase, M16
GPW66_RS13830	COG0583	DNA-binding transcription factor activity
GPW66_RS13835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPW66_RS13845	COG2350	Protein conserved in bacteria
GPW66_RS13850	COG1607	acyl-coa hydrolase
GPW66_RS13855	COG2917	probably involved in intracellular septation
GPW66_RS13865	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW66_RS13870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW66_RS13880	COG2116	formate transmembrane transporter activity
GPW66_RS13885	COG4459	periplasmic nitrate reductase
GPW66_RS13890	COG3005	denitrification pathway
GPW66_RS13895	COG0243	molybdopterin cofactor binding
GPW66_RS13910	COG1227	inorganic diphosphatase activity
GPW66_RS13925	COG4172	Belongs to the ABC transporter superfamily
GPW66_RS13935	COG4171	peptide transport system, permease
GPW66_RS13940	COG4168	peptide transport system, permease
GPW66_RS13950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPW66_RS13955	COG1842	Phage shock protein A
GPW66_RS13970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW66_RS13985	COG2818	Glycosylase
GPW66_RS13990	COG0626	cystathionine gamma-synthase activity
GPW66_RS14000	COG0733	neurotransmitter:sodium symporter activity
GPW66_RS14005	COG0564	pseudouridine synthase activity
GPW66_RS14010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPW66_RS14015	COG4136	ATPase activity
GPW66_RS14020	COG4135	transport system, permease component
GPW66_RS14025	COG4134	Bacterial extracellular solute-binding protein
GPW66_RS14035	COG3313	Fe-S protein
GPW66_RS14045	COG0842	Transport permease protein
GPW66_RS14050	COG1131	(ABC) transporter
GPW66_RS14055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW66_RS14060	COG0814	amino acid
GPW66_RS14070	COG2239	Acts as a magnesium transporter
GPW66_RS14090	COG4934	collagen metabolic process
GPW66_RS14125	COG0840	transmembrane signaling receptor activity
GPW66_RS14135	COG2203	Gaf domain
GPW66_RS14135	COG3706	GGDEF domain
GPW66_RS14135	COG5001	Diguanylate cyclase
GPW66_RS14135	COG4251	negative regulation of phosphorylation
GPW66_RS14140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPW66_RS14145	COG5002	protein histidine kinase activity
GPW66_RS14160	COG1061	Type III restriction enzyme res subunit
GPW66_RS14165	COG1187	pseudouridine synthase activity
GPW66_RS14170	COG2814	Major facilitator Superfamily
GPW66_RS14180	COG0702	epimerase
GPW66_RS14185	COG0534	Mate efflux family protein
GPW66_RS14190	COG4181	ATPase activity
GPW66_RS14205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW66_RS14215	COG1748	Saccharopine dehydrogenase
GPW66_RS14220	COG0019	diaminopimelate decarboxylase activity
GPW66_RS14230	COG1538	Outer membrane efflux protein
GPW66_RS14240	COG3385	transposase activity
GPW66_RS14250	COG1538	Outer membrane efflux protein
GPW66_RS14255	COG1566	PFAM secretion protein HlyD family protein
GPW66_RS14260	COG2814	Major facilitator Superfamily
GPW66_RS14265	COG0840	transmembrane signaling receptor activity
GPW66_RS14270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPW66_RS14280	COG3501	Rhs element vgr protein
GPW66_RS14300	COG1280	lysine exporter protein (LysE YggA)
GPW66_RS14305	COG1115	amino acid carrier protein
GPW66_RS14320	COG3385	transposase activity
GPW66_RS14325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW66_RS14330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW66_RS14335	COG1177	transmembrane transport
GPW66_RS14340	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPW66_RS14345	COG3842	ATPase activity
GPW66_RS14365	COG0037	tRNA processing
GPW66_RS14370	COG0589	response to stress
GPW66_RS14375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW66_RS14390	COG2217	Heavy metal translocating P-type atpase
GPW66_RS14400	COG2010	Cytochrome c
GPW66_RS14415	COG3278	Belongs to the heme-copper respiratory oxidase family
GPW66_RS14430	COG2205	protein histidine kinase activity
GPW66_RS14430	COG0784	Response regulator, receiver
GPW66_RS14455	COG2994	toxin metabolic process
GPW66_RS14460	COG3064	Membrane
GPW66_RS14460	COG1073	alpha beta
GPW66_RS14460	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPW66_RS14520	COG4128	Pfam Zonular occludens toxin
GPW66_RS14555	COG4128	Pfam Zonular occludens toxin
GPW66_RS14590	COG4128	Pfam Zonular occludens toxin
GPW66_RS14625	COG4128	Pfam Zonular occludens toxin
GPW66_RS14735	COG3120	sequence-specific DNA binding
GPW66_RS14740	COG1067	ATP-dependent peptidase activity
GPW66_RS14745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW66_RS14770	COG0116	Belongs to the methyltransferase superfamily
GPW66_RS14770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW66_RS14780	COG0167	dihydroorotate dehydrogenase activity
GPW66_RS14795	COG0308	aminopeptidase N
GPW66_RS14810	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPW66_RS14815	COG1956	GAF domain-containing protein
GPW66_RS14820	COG1132	(ABC) transporter
GPW66_RS14825	COG2995	paraquat-inducible protein a
GPW66_RS14830	COG3008	intermembrane lipid transfer
GPW66_RS14835	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPW66_RS14835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW66_RS14840	COG2996	Protein conserved in bacteria
GPW66_RS14855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW66_RS14865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPW66_RS14880	COG0437	4 iron, 4 sulfur cluster binding
GPW66_RS14885	COG3383	formate dehydrogenase (NAD+) activity
GPW66_RS14885	COG0243	molybdopterin cofactor binding
GPW66_RS14915	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPW66_RS14920	COG0488	(ABC) transporter
GPW66_RS14925	COG3852	Histidine kinase
GPW66_RS14930	COG2204	response regulator
GPW66_RS14940	COG4662	Binding-protein-dependent transport system inner membrane component
GPW66_RS14945	COG3842	ATPase activity
GPW66_RS14950	COG0746	molybdenum cofactor guanylyltransferase activity
GPW66_RS14965	COG1940	carbohydrate kinase activity
GPW66_RS14980	COG0840	transmembrane signaling receptor activity
GPW66_RS14985	COG0791	NLP P60 protein
GPW66_RS15005	COG0534	Mate efflux family protein
GPW66_RS15015	COG1793	dna ligase
GPW66_RS15025	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW66_RS15030	COG0848	biopolymer transport protein
GPW66_RS15035	COG0811	peptide transport
GPW66_RS15040	COG0811	peptide transport
GPW66_RS15055	COG1175	transmembrane transport
GPW66_RS15060	COG0395	ABC-type sugar transport system, permease component
GPW66_RS15065	COG3842	ATPase activity
GPW66_RS15070	COG1349	DNA-binding transcription factor activity
GPW66_RS15075	COG0584	glycerophosphoryl diester phosphodiesterase
GPW66_RS15080	COG2731	YhcH YjgK YiaL family protein
GPW66_RS15085	COG0251	oxidation-reduction process
GPW66_RS15090	COG1609	Transcriptional regulator
GPW66_RS15095	COG2723	6-phospho-beta-galactosidase activity
GPW66_RS15100	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPW66_RS15125	COG0577	efflux transmembrane transporter activity
GPW66_RS15125	COG1136	(ABC) transporter
GPW66_RS15130	COG1136	(ABC) transporter
GPW66_RS15130	COG0577	efflux transmembrane transporter activity
GPW66_RS15135	COG1136	(ABC) transporter
GPW66_RS15135	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW66_RS15140	COG1294	oxidase, subunit
GPW66_RS15145	COG1271	oxidase subunit
GPW66_RS15195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW66_RS15210	COG3527	Alpha-acetolactate decarboxylase
GPW66_RS15225	COG2199	diguanylate cyclase activity
GPW66_RS15225	COG2200	EAL domain
GPW66_RS15230	COG3706	GGDEF domain
GPW66_RS15235	COG2017	converts alpha-aldose to the beta-anomer
GPW66_RS15240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPW66_RS15245	COG1085	galactose-1-phosphate uridylyltransferase
GPW66_RS15270	COG0745	RESPONSE REGULATOR receiver
GPW66_RS15270	COG3706	GGDEF domain
GPW66_RS15290	COG0835	chemotaxis
GPW66_RS15290	COG0784	Response regulator, receiver
GPW66_RS15300	COG4565	transcriptional regulatory protein
GPW66_RS15305	COG3290	protein histidine kinase activity
GPW66_RS15320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW66_RS15340	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPW66_RS15345	COG3063	Type IV pilus biogenesis stability protein PilW
GPW66_RS15360	COG1451	nucleotide metabolic process
GPW66_RS15370	COG0583	DNA-binding transcription factor activity
GPW66_RS15390	COG0513	Belongs to the DEAD box helicase family
GPW66_RS15400	COG0840	transmembrane signaling receptor activity
GPW66_RS15405	COG0840	transmembrane signaling receptor activity
GPW66_RS15410	COG0835	chemotaxis
GPW66_RS15415	COG2201	protein-glutamate methylesterase activity
GPW66_RS15425	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW66_RS15435	COG0643	Histidine kinase
GPW66_RS15435	COG2198	Histidine kinase
GPW66_RS15455	COG2076	Multidrug Resistance protein
GPW66_RS15460	COG0415	Belongs to the DNA photolyase family
GPW66_RS15465	COG0477	Major facilitator Superfamily
GPW66_RS15470	COG0583	DNA-binding transcription factor activity
GPW66_RS15480	COG0402	S-adenosylhomocysteine deaminase activity
GPW66_RS15485	COG0095	Lipoate-protein ligase
GPW66_RS15490	COG0443	Heat shock 70 kDa protein
GPW66_RS15510	COG1643	Atp-dependent helicase
GPW66_RS15545	COG0443	Heat shock 70 kDa protein
GPW66_RS15550	COG0443	Heat shock 70 kDa protein
GPW66_RS15555	COG3706	GGDEF domain
GPW66_RS15585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPW66_RS15590	COG0602	queuosine metabolic process
GPW66_RS15595	COG0561	phosphatase activity
GPW66_RS15605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW66_RS15610	COG4597	amino acid ABC transporter
GPW66_RS15615	COG0765	amino acid transport
GPW66_RS15620	COG1126	abc transporter atp-binding protein
GPW66_RS15625	COG0670	Belongs to the BI1 family
GPW66_RS15630	COG2920	part of a sulfur-relay system
GPW66_RS15635	COG1254	Belongs to the acylphosphatase family
GPW66_RS15640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW66_RS15645	COG3706	GGDEF domain
GPW66_RS15655	COG2205	protein histidine kinase activity
GPW66_RS15655	COG3850	Histidine kinase
GPW66_RS15655	COG4999	Histidine kinase
GPW66_RS15655	COG3437	response regulator, receiver
GPW66_RS15660	COG3437	response regulator, receiver
GPW66_RS15665	COG0625	glutathione transferase activity
GPW66_RS15675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPW66_RS15685	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW66_RS15715	COG0372	Belongs to the citrate synthase family
GPW66_RS15720	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPW66_RS15725	COG2186	Transcriptional regulator
GPW66_RS15760	COG1129	ABC transporter
GPW66_RS15785	COG0745	RESPONSE REGULATOR receiver
GPW66_RS15790	COG5002	protein histidine kinase activity
GPW66_RS15795	COG3713	MltA-interacting MipA family protein
GPW66_RS15800	COG2990	Protein conserved in bacteria
GPW66_RS15810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW66_RS15810	COG4191	Histidine kinase
GPW66_RS15815	COG0471	metal ion transport
GPW66_RS15825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW66_RS15840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW66_RS15845	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPW66_RS15850	COG3768	UPF0283 membrane protein
GPW66_RS15855	COG3106	COG3106 Predicted ATPase
GPW66_RS15870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW66_RS15875	COG0494	nUDIX hydrolase
GPW66_RS15880	COG0814	amino acid
GPW66_RS15885	COG1760	l-serine dehydratase
GPW66_RS15890	COG0720	synthase
GPW66_RS15895	COG0840	transmembrane signaling receptor activity
GPW66_RS15900	COG0017	Asparaginyl-tRNA synthetase
GPW66_RS15905	COG0351	phosphomethylpyrimidine kinase
GPW66_RS15910	COG2770	Histidine kinase
GPW66_RS15910	COG3437	response regulator, receiver
GPW66_RS15920	COG1448	Aminotransferase
GPW66_RS15935	COG0840	transmembrane signaling receptor activity
GPW66_RS15940	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPW66_RS15945	COG2943	transferase activity, transferring hexosyl groups
GPW66_RS15950	COG1609	Transcriptional regulator
GPW66_RS15955	COG3394	polysaccharide catabolic process
GPW66_RS15960	COG1486	melibiose metabolic process
GPW66_RS15965	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPW66_RS15975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPW66_RS15980	COG0726	polysaccharide deacetylase
GPW66_RS15985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPW66_RS15990	COG1846	Transcriptional regulator
GPW66_RS16015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW66_RS16030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW66_RS16035	COG3108	Peptidase M15
GPW66_RS16065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW66_RS16075	COG2814	Major facilitator Superfamily
GPW66_RS16095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW66_RS16100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW66_RS16105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW66_RS16150	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPW66_RS16155	COG4139	cobalamin transport
GPW66_RS16160	COG2988	succinylglutamate desuccinylase activity
GPW66_RS16175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPW66_RS16180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPW66_RS16185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW66_RS16195	COG2925	Exonuclease
GPW66_RS16205	COG1346	cytolysis
GPW66_RS16210	COG0295	cytidine deaminase activity
GPW66_RS16230	COG0500	methyltransferase
GPW66_RS16245	COG0776	regulation of translation
GPW66_RS16250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW66_RS16250	COG0072	phenylalanine-tRNA ligase activity
GPW66_RS16255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPW66_RS16265	COG3706	GGDEF domain
GPW66_RS16265	COG0745	RESPONSE REGULATOR receiver
GPW66_RS16295	COG0322	excinuclease ABC activity
GPW66_RS16300	COG2197	response regulator
GPW66_RS16305	COG0417	DNA replication proofreading
GPW66_RS16310	COG5001	Diguanylate cyclase
GPW66_RS16320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW66_RS16340	COG1228	amidohydrolase
GPW66_RS16345	COG0010	Belongs to the arginase family
GPW66_RS16350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPW66_RS16355	COG2986	histidine ammonia-lyase
GPW66_RS16375	COG0277	FAD linked oxidase domain protein
GPW66_RS16375	COG0247	lactate metabolic process
GPW66_RS16390	COG2885	chlorophyll binding
GPW66_RS16410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPW66_RS16420	COG0281	malic enzyme
GPW66_RS16430	COG2949	membrane
GPW66_RS16435	COG3706	GGDEF domain
GPW66_RS16440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW66_RS16450	COG0492	ferredoxin-NADP+ reductase activity
GPW66_RS16455	COG4988	ABC transporter
GPW66_RS16460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPW66_RS16465	COG1187	pseudouridine synthase activity
GPW66_RS16470	COG0009	L-threonylcarbamoyladenylate synthase
GPW66_RS16475	COG0613	PHP domain protein
GPW66_RS16485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW66_RS16490	COG0512	Glutamine amidotransferase of anthranilate synthase
GPW66_RS16495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPW66_RS16500	COG0135	phosphoribosylanthranilate isomerase activity
GPW66_RS16500	COG0134	indole-3-glycerol-phosphate synthase activity
GPW66_RS16505	COG0133	tryptophan synthase activity
GPW66_RS16510	COG0159	tryptophan synthase activity
GPW66_RS16520	COG1435	thymidine kinase activity
GPW66_RS16525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPW66_RS16530	COG1801	Protein of unknown function DUF72
GPW66_RS16535	COG4106	trans-aconitate 2-methyltransferase activity
GPW66_RS16540	COG0500	methyltransferase
GPW66_RS16545	COG4067	protein conserved in archaea
GPW66_RS16545	COG0189	ligase activity
GPW66_RS16560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPW66_RS16570	COG3852	Histidine kinase
GPW66_RS16585	COG3070	regulator of competence-specific genes
GPW66_RS16595	COG2431	L-lysine efflux transmembrane transporter activity
GPW66_RS16605	COG0076	glutamate decarboxylase activity
GPW66_RS16610	COG1737	Transcriptional regulator
GPW66_RS16615	COG1454	alcohol dehydrogenase
GPW66_RS16615	COG1012	belongs to the aldehyde dehydrogenase family
GPW66_RS16620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW66_RS16630	COG0542	response to heat
GPW66_RS16635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPW66_RS16640	COG1278	Cold shock
GPW66_RS16650	COG1187	pseudouridine synthase activity
GPW66_RS16655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPW66_RS16655	COG0140	phosphoribosyl-ATP diphosphatase activity
GPW66_RS16660	COG0107	imidazoleglycerol-phosphate synthase activity
GPW66_RS16665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPW66_RS16670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPW66_RS16675	COG0131	Imidazoleglycerol-phosphate dehydratase
GPW66_RS16675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW66_RS16680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPW66_RS16685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPW66_RS16690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPW66_RS16695	COG1757	Na H antiporter
GPW66_RS16700	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPW66_RS16705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW66_RS16710	COG0482	sulfurtransferase activity
GPW66_RS16715	COG2915	High frequency lysogenization protein hflD homolog
GPW66_RS16720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPW66_RS16730	COG2268	Band 7 protein
GPW66_RS16740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPW66_RS16755	COG0300	oxidoreductase activity
GPW66_RS16765	COG0501	Belongs to the peptidase M48B family
GPW66_RS16775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPW66_RS16780	COG2226	methyltransferase
GPW66_RS16785	COG0156	8-amino-7-oxononanoate synthase activity
GPW66_RS16790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW66_RS16795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPW66_RS16800	COG3385	transposase activity
GPW66_RS16805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPW66_RS16810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPW66_RS16815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPW66_RS16820	COG0653	protein targeting
GPW66_RS16825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW66_RS16830	COG2203	Gaf domain
GPW66_RS16830	COG2199	diguanylate cyclase activity
GPW66_RS16840	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPW66_RS16850	COG4628	conserved protein (DUF2132)
GPW66_RS16855	COG3092	negative regulation of chromosome organization
GPW66_RS16860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW66_RS16865	COG0857	belongs to the CobB CobQ family
GPW66_RS16865	COG0280	phosphate acetyltransferase
GPW66_RS16870	COG0435	Glutathione S-transferase
GPW66_RS16875	COG4608	Belongs to the ABC transporter superfamily
GPW66_RS16880	COG0444	Belongs to the ABC transporter superfamily
GPW66_RS16885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW66_RS16890	COG0601	transmembrane transport
GPW66_RS16910	COG2204	response regulator
GPW66_RS16915	COG3300	MHYT domain
GPW66_RS16915	COG5001	Diguanylate cyclase
GPW66_RS16920	COG4191	Histidine kinase
GPW66_RS16925	COG5002	protein histidine kinase activity
GPW66_RS16935	COG2201	protein-glutamate methylesterase activity
GPW66_RS16950	COG0009	L-threonylcarbamoyladenylate synthase
GPW66_RS16970	COG1881	PFAM PEBP family protein
GPW66_RS16995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW66_RS17000	COG0640	Transcriptional regulator
GPW66_RS17010	COG3706	GGDEF domain
GPW66_RS17030	COG1946	Acyl-CoA thioesterase
GPW66_RS17035	COG1522	sequence-specific DNA binding
GPW66_RS17045	COG0616	signal peptide processing
GPW66_RS17050	COG1028	Short-chain dehydrogenase reductase Sdr
GPW66_RS17065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPW66_RS17070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPW66_RS17075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GPW66_RS17080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPW66_RS17085	COG2832	Protein of unknown function (DUF454)
GPW66_RS17095	COG0745	RESPONSE REGULATOR receiver
GPW66_RS17100	COG0583	DNA-binding transcription factor activity
GPW66_RS17105	COG0778	Nitroreductase
GPW66_RS17110	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW66_RS17110	COG1024	Enoyl-CoA hydratase
GPW66_RS17115	COG0183	Belongs to the thiolase family
GPW66_RS17130	COG2067	long-chain fatty acid transport protein
GPW66_RS17140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW66_RS17145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPW66_RS17150	COG2982	Protein involved in outer membrane biogenesis
GPW66_RS17155	COG0572	uridine kinase
GPW66_RS17160	COG0489	protein tyrosine kinase activity
GPW66_RS17165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW66_RS17165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW66_RS17175	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPW66_RS17185	COG4109	DRTGG domain
GPW66_RS17190	COG2199	diguanylate cyclase activity
GPW66_RS17195	COG0314	molybdopterin synthase activity
GPW66_RS17200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPW66_RS17205	COG0315	cyclic pyranopterin monophosphate synthase activity
GPW66_RS17210	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPW66_RS17215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPW66_RS17220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPW66_RS17225	COG2198	Histidine kinase
GPW66_RS17230	COG2204	response regulator
GPW66_RS17235	COG0556	nucleotide-excision repair
GPW66_RS17250	COG4657	Part of a membrane complex involved in electron transport
GPW66_RS17255	COG2878	Part of a membrane complex involved in electron transport
GPW66_RS17260	COG4656	Part of a membrane complex involved in electron transport
GPW66_RS17265	COG4658	electron transport chain
GPW66_RS17270	COG4659	FMN binding
GPW66_RS17275	COG4660	Part of a membrane complex involved in electron transport
GPW66_RS17280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPW66_RS17285	COG0346	lactoylglutathione lyase activity
GPW66_RS17300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW66_RS17305	COG2056	Na+-H+ antiporter family
GPW66_RS17310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPW66_RS17315	COG1286	toxin biosynthetic process
GPW66_RS17320	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPW66_RS17325	COG0285	dihydrofolate synthase activity
GPW66_RS17330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPW66_RS17335	COG0101	tRNA pseudouridine synthase activity
GPW66_RS17345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW66_RS17350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW66_RS17350	COG2190	(PTS) system
GPW66_RS17350	COG1263	PTS System
GPW66_RS17355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW66_RS17360	COG1940	carbohydrate kinase activity
GPW66_RS17360	COG1846	Transcriptional regulator
GPW66_RS17365	COG4651	solute:proton antiporter activity
GPW66_RS17365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW66_RS17370	COG0367	asparagine synthase
GPW66_RS17385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPW66_RS17390	COG0563	adenylate kinase activity
GPW66_RS17395	COG0326	Molecular chaperone. Has ATPase activity
GPW66_RS17400	COG3710	Transcriptional regulator
GPW66_RS17415	COG0622	Phosphoesterase
GPW66_RS17420	COG1090	epimerase
GPW66_RS17425	COG0300	oxidoreductase activity
GPW66_RS17435	COG3118	belongs to the thioredoxin family
GPW66_RS17440	COG0330	HflC and HflK could
GPW66_RS17445	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPW66_RS17450	COG0789	Transcriptional regulator
GPW66_RS17465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPW66_RS17470	COG3115	cell septum assembly
GPW66_RS17475	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPW66_RS17480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPW66_RS17490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW66_RS17500	COG2190	(PTS) system
GPW66_RS17505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW66_RS17510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW66_RS17515	COG1702	phosphate starvation-inducible protein PhoH
GPW66_RS17520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPW66_RS17525	COG4535	Mg2 and Co2 transporter CorC
GPW66_RS17530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPW66_RS17535	COG2888	peptidyl-tyrosine sulfation
GPW66_RS17540	COG0495	leucyl-tRNA aminoacylation
GPW66_RS17545	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPW66_RS17550	COG1466	dna polymerase III delta subunit
GPW66_RS17555	COG0799	negative regulation of ribosome biogenesis
GPW66_RS17560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPW66_RS17565	COG0768	penicillin binding
GPW66_RS17570	COG0772	Belongs to the SEDS family
GPW66_RS17575	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW66_RS17580	COG1686	Belongs to the peptidase S11 family
GPW66_RS17585	COG2921	Belongs to the UPF0250 family
GPW66_RS17590	COG0321	lipoyl(octanoyl) transferase activity
GPW66_RS17595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPW66_RS17605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW66_RS17630	COG1596	polysaccharide export
GPW66_RS17640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW66_RS17670	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPW66_RS17680	COG0438	transferase activity, transferring glycosyl groups
GPW66_RS17690	COG1045	serine acetyltransferase
GPW66_RS17715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPW66_RS17720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPW66_RS17725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW66_RS17730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW66_RS17760	COG0366	Alpha amylase catalytic
GPW66_RS17765	COG1263	PTS System
GPW66_RS17765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW66_RS17770	COG1609	Transcriptional regulator
GPW66_RS17775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW66_RS17780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPW66_RS17785	COG2011	ABC-type metal ion transport system permease component
GPW66_RS17790	COG1464	Belongs to the NlpA lipoprotein family
GPW66_RS17795	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPW66_RS17805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW66_RS17805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW66_RS17815	COG3706	GGDEF domain
GPW66_RS17820	COG1611	Belongs to the LOG family
GPW66_RS17825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW66_RS17830	COG2363	Small membrane protein
GPW66_RS17835	COG0583	DNA-binding transcription factor activity
GPW66_RS17840	COG0301	tRNA thio-modification
GPW66_RS17840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW66_RS17850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPW66_RS17855	COG1722	exodeoxyribonuclease VII activity
GPW66_RS17860	COG0142	geranyltranstransferase activity
GPW66_RS17865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPW66_RS17870	COG0564	pseudouridine synthase activity
GPW66_RS17875	COG3098	single-species biofilm formation
GPW66_RS17890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW66_RS17900	COG1671	Belongs to the UPF0178 family
GPW66_RS17905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW66_RS17910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPW66_RS17915	COG0254	rRNA binding
GPW66_RS17920	COG1720	tRNA m6t6A37 methyltransferase activity
GPW66_RS17925	COG0442	prolyl-tRNA aminoacylation
GPW66_RS17930	COG1943	Transposase
GPW66_RS17950	COG0047	phosphoribosylformylglycinamidine synthase activity
GPW66_RS17950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPW66_RS17960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPW66_RS17965	COG0590	tRNA wobble adenosine to inosine editing
GPW66_RS17970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW66_RS18005	COG0484	heat shock protein binding
GPW66_RS18010	COG0443	Heat shock 70 kDa protein
GPW66_RS18015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPW66_RS18020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPW66_RS18025	COG0497	DNA recombination
GPW66_RS18030	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW66_RS18035	COG2914	Belongs to the UPF0125 (RnfH) family
GPW66_RS18040	COG2867	negative regulation of translational initiation
GPW66_RS18045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPW66_RS18070	COG3064	Membrane
GPW66_RS18080	COG0739	heme binding
GPW66_RS18095	COG0840	transmembrane signaling receptor activity
GPW66_RS18100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GPW66_RS18105	COG2207	Transcriptional regulator
GPW66_RS18115	COG1459	type II secretion system
GPW66_RS18120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW66_RS18140	COG4796	Type ii and iii secretion system protein
GPW66_RS18155	COG2165	general secretion pathway protein
GPW66_RS18165	COG3710	Transcriptional regulator
GPW66_RS18170	COG0840	transmembrane signaling receptor activity
GPW66_RS18175	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GPW66_RS18195	COG1012	belongs to the aldehyde dehydrogenase family
GPW66_RS18210	COG2003	Belongs to the UPF0758 family
GPW66_RS18295	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPW66_RS18300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPW66_RS18305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW66_RS18315	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPW66_RS18320	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPW66_RS18325	COG3051	citrate lyase alpha subunit
GPW66_RS18330	COG2301	Belongs to the HpcH HpaI aldolase family
GPW66_RS18335	COG3052	prosthetic group binding
GPW66_RS18340	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPW66_RS18350	COG3630	sodium ion export across plasma membrane
GPW66_RS18355	COG0511	ligase activity, forming carbon-carbon bonds
GPW66_RS18355	COG5016	pyruvate
GPW66_RS18360	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW66_RS18370	COG4565	transcriptional regulatory protein
GPW66_RS18385	COG0583	DNA-binding transcription factor activity
GPW66_RS18390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW66_RS18395	COG1115	amino acid carrier protein
GPW66_RS18400	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPW66_RS18405	COG0583	DNA-binding transcription factor activity
GPW66_RS18415	COG1120	ATPase activity
GPW66_RS18420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW66_RS18425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW66_RS18430	COG4592	Periplasmic binding protein
GPW66_RS18440	COG1028	Short-chain dehydrogenase reductase Sdr
GPW66_RS18445	COG1169	isochorismate synthase
GPW66_RS18450	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPW66_RS18455	COG3433	isochorismatase activity
GPW66_RS18455	COG1535	isochorismatase
GPW66_RS18460	COG1584	GPR1 FUN34 yaaH family protein
GPW66_RS18470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPW66_RS18470	COG0519	Catalyzes the synthesis of GMP from XMP
GPW66_RS18475	COG0517	IMP dehydrogenase activity
GPW66_RS18475	COG0516	GMP reductase activity
GPW66_RS18480	COG1570	exodeoxyribonuclease VII activity
GPW66_RS18495	COG1160	GTP binding
GPW66_RS18500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW66_RS18505	COG2976	Protein conserved in bacteria
GPW66_RS18510	COG0124	histidyl-tRNA synthetase
GPW66_RS18515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPW66_RS18530	COG0105	UTP biosynthetic process
GPW66_RS18535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW66_RS18540	COG2975	iron-sulfur cluster assembly
GPW66_RS18545	COG0633	Ferredoxin
GPW66_RS18555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW66_RS18565	COG0822	iron-sulfur transferase activity
GPW66_RS18575	COG1959	2 iron, 2 sulfur cluster binding
GPW66_RS18585	COG0483	inositol monophosphate 1-phosphatase activity
GPW66_RS18590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW66_RS18595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW66_RS18600	COG1862	Preprotein translocase
GPW66_RS18605	COG0343	queuine tRNA-ribosyltransferase activity
GPW66_RS18610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPW66_RS18615	COG0517	IMP dehydrogenase activity
GPW66_RS18625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPW66_RS18630	COG0583	DNA-binding transcription factor activity
GPW66_RS18635	COG0450	alkyl hydroperoxide reductase
GPW66_RS18640	COG3142	Participates in the control of copper homeostasis
GPW66_RS18655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW66_RS18660	COG0581	inorganic phosphate transmembrane transporter activity
GPW66_RS18670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPW66_RS18675	COG0248	Ppx GppA phosphatase
GPW66_RS18685	COG5002	protein histidine kinase activity
GPW66_RS18690	COG0745	RESPONSE REGULATOR receiver
GPW66_RS18695	COG2974	May be involved in recombination
GPW66_RS18705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW66_RS18765	COG0542	response to heat
GPW66_RS18775	COG0564	pseudouridine synthase activity
GPW66_RS18780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW66_RS18785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW66_RS18790	COG1605	Chorismate mutase
GPW66_RS18790	COG0077	Prephenate dehydratase
GPW66_RS18795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW66_RS18800	COG5001	Diguanylate cyclase
GPW66_RS18805	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPW66_RS18810	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPW66_RS18820	COG0488	(ABC) transporter
GPW66_RS18830	COG1605	Chorismate mutase
GPW66_RS18830	COG0287	Prephenate dehydrogenase
GPW66_RS18835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW66_RS18840	COG3275	phosphorelay sensor kinase activity
GPW66_RS18845	COG3279	Response regulator of the LytR AlgR family
GPW66_RS18850	COG1472	Belongs to the glycosyl hydrolase 3 family
GPW66_RS18855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPW66_RS18860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW66_RS18875	COG1966	Carbon starvation protein
GPW66_RS18880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPW66_RS18885	COG1047	Peptidyl-prolyl cis-trans
GPW66_RS18890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPW66_RS18895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPW66_RS18900	COG0196	riboflavin kinase activity
GPW66_RS18905	COG0728	peptidoglycan biosynthetic process
GPW66_RS18910	COG0268	Binds directly to 16S ribosomal RNA
GPW66_RS18915	COG0640	Transcriptional regulator
GPW66_RS18920	COG0583	DNA-binding transcription factor activity
GPW66_RS18925	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPW66_RS18930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPW66_RS18935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPW66_RS18940	COG0730	response to heat
GPW66_RS18945	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPW66_RS18950	COG0494	nUDIX hydrolase
GPW66_RS18955	COG3066	DNA modification
GPW66_RS18960	COG0667	Aldo Keto reductase
GPW66_RS18975	COG2204	response regulator
GPW66_RS18980	COG3385	transposase activity
GPW66_RS18985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPW66_RS19000	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPW66_RS19005	COG0513	Belongs to the DEAD box helicase family
GPW66_RS19010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPW66_RS19030	COG3153	acetyltransferase