locus-tag	class	description
GPY00_RS00010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY00_RS00010	COG4191	Histidine kinase
GPY00_RS00015	COG0471	metal ion transport
GPY00_RS00025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY00_RS00040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY00_RS00045	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY00_RS00050	COG3768	UPF0283 membrane protein
GPY00_RS00055	COG3106	COG3106 Predicted ATPase
GPY00_RS00070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY00_RS00075	COG0494	nUDIX hydrolase
GPY00_RS00080	COG0814	amino acid
GPY00_RS00085	COG1760	l-serine dehydratase
GPY00_RS00090	COG0720	synthase
GPY00_RS00095	COG0840	transmembrane signaling receptor activity
GPY00_RS00100	COG0017	Asparaginyl-tRNA synthetase
GPY00_RS00105	COG0351	phosphomethylpyrimidine kinase
GPY00_RS00110	COG3437	response regulator, receiver
GPY00_RS00110	COG2770	Histidine kinase
GPY00_RS00120	COG1448	Aminotransferase
GPY00_RS00135	COG0840	transmembrane signaling receptor activity
GPY00_RS00140	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPY00_RS00145	COG2943	transferase activity, transferring hexosyl groups
GPY00_RS00150	COG1609	Transcriptional regulator
GPY00_RS00155	COG3394	polysaccharide catabolic process
GPY00_RS00160	COG1486	melibiose metabolic process
GPY00_RS00165	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY00_RS00175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY00_RS00180	COG0726	polysaccharide deacetylase
GPY00_RS00185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY00_RS00190	COG1846	Transcriptional regulator
GPY00_RS00215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY00_RS00230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY00_RS00235	COG3108	Peptidase M15
GPY00_RS00265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY00_RS00275	COG2814	Major facilitator Superfamily
GPY00_RS00295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY00_RS00300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY00_RS00305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY00_RS00350	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY00_RS00355	COG4139	cobalamin transport
GPY00_RS00360	COG2988	succinylglutamate desuccinylase activity
GPY00_RS00375	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY00_RS00380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY00_RS00385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY00_RS00395	COG2925	Exonuclease
GPY00_RS00405	COG1346	cytolysis
GPY00_RS00410	COG0295	cytidine deaminase activity
GPY00_RS00430	COG0500	methyltransferase
GPY00_RS00445	COG0776	regulation of translation
GPY00_RS00450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY00_RS00450	COG0072	phenylalanine-tRNA ligase activity
GPY00_RS00455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY00_RS00465	COG0745	RESPONSE REGULATOR receiver
GPY00_RS00465	COG3706	GGDEF domain
GPY00_RS00495	COG0322	excinuclease ABC activity
GPY00_RS00500	COG2197	response regulator
GPY00_RS00505	COG0417	DNA replication proofreading
GPY00_RS00510	COG5001	Diguanylate cyclase
GPY00_RS00520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY00_RS00540	COG1228	amidohydrolase
GPY00_RS00545	COG0010	Belongs to the arginase family
GPY00_RS00550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY00_RS00555	COG2986	histidine ammonia-lyase
GPY00_RS00575	COG0247	lactate metabolic process
GPY00_RS00575	COG0277	FAD linked oxidase domain protein
GPY00_RS00590	COG2885	chlorophyll binding
GPY00_RS00610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY00_RS00620	COG0281	malic enzyme
GPY00_RS00630	COG2949	membrane
GPY00_RS00635	COG3706	GGDEF domain
GPY00_RS00640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY00_RS00650	COG0492	ferredoxin-NADP+ reductase activity
GPY00_RS00655	COG4988	ABC transporter
GPY00_RS00660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY00_RS00665	COG1187	pseudouridine synthase activity
GPY00_RS00670	COG0009	L-threonylcarbamoyladenylate synthase
GPY00_RS00675	COG0613	PHP domain protein
GPY00_RS00685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY00_RS00690	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY00_RS00695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY00_RS00700	COG0134	indole-3-glycerol-phosphate synthase activity
GPY00_RS00700	COG0135	phosphoribosylanthranilate isomerase activity
GPY00_RS00705	COG0133	tryptophan synthase activity
GPY00_RS00710	COG0159	tryptophan synthase activity
GPY00_RS00720	COG1435	thymidine kinase activity
GPY00_RS00725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY00_RS00730	COG1801	Protein of unknown function DUF72
GPY00_RS00735	COG4106	trans-aconitate 2-methyltransferase activity
GPY00_RS00740	COG0500	methyltransferase
GPY00_RS00745	COG0189	ligase activity
GPY00_RS00745	COG4067	protein conserved in archaea
GPY00_RS00760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY00_RS00770	COG3852	Histidine kinase
GPY00_RS00785	COG3070	regulator of competence-specific genes
GPY00_RS00795	COG2431	L-lysine efflux transmembrane transporter activity
GPY00_RS00805	COG0076	glutamate decarboxylase activity
GPY00_RS00810	COG1737	Transcriptional regulator
GPY00_RS00815	COG1012	belongs to the aldehyde dehydrogenase family
GPY00_RS00815	COG1454	alcohol dehydrogenase
GPY00_RS00820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY00_RS00830	COG0542	response to heat
GPY00_RS00835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY00_RS00840	COG1278	Cold shock
GPY00_RS00850	COG1187	pseudouridine synthase activity
GPY00_RS00855	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY00_RS00855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY00_RS00860	COG0107	imidazoleglycerol-phosphate synthase activity
GPY00_RS00865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY00_RS00870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY00_RS00875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY00_RS00875	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY00_RS00880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY00_RS00885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY00_RS00890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY00_RS00895	COG1757	Na H antiporter
GPY00_RS00900	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY00_RS00905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY00_RS00910	COG0482	sulfurtransferase activity
GPY00_RS00915	COG2915	High frequency lysogenization protein hflD homolog
GPY00_RS00920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY00_RS00930	COG2268	Band 7 protein
GPY00_RS00940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY00_RS00955	COG0300	oxidoreductase activity
GPY00_RS00965	COG0501	Belongs to the peptidase M48B family
GPY00_RS00975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY00_RS00980	COG2226	methyltransferase
GPY00_RS00985	COG0156	8-amino-7-oxononanoate synthase activity
GPY00_RS00990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY00_RS01000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY00_RS01005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY00_RS01010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY00_RS01015	COG0653	protein targeting
GPY00_RS01020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY00_RS01025	COG2203	Gaf domain
GPY00_RS01025	COG2199	diguanylate cyclase activity
GPY00_RS01035	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY00_RS01045	COG4628	conserved protein (DUF2132)
GPY00_RS01050	COG3092	negative regulation of chromosome organization
GPY00_RS01055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY00_RS01060	COG0857	belongs to the CobB CobQ family
GPY00_RS01060	COG0280	phosphate acetyltransferase
GPY00_RS01065	COG0435	Glutathione S-transferase
GPY00_RS01070	COG4608	Belongs to the ABC transporter superfamily
GPY00_RS01075	COG0444	Belongs to the ABC transporter superfamily
GPY00_RS01080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY00_RS01085	COG0601	transmembrane transport
GPY00_RS01105	COG2204	response regulator
GPY00_RS01110	COG5001	Diguanylate cyclase
GPY00_RS01110	COG3300	MHYT domain
GPY00_RS01115	COG4191	Histidine kinase
GPY00_RS01120	COG5002	protein histidine kinase activity
GPY00_RS01130	COG2201	protein-glutamate methylesterase activity
GPY00_RS01145	COG0009	L-threonylcarbamoyladenylate synthase
GPY00_RS01165	COG1881	PFAM PEBP family protein
GPY00_RS01190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY00_RS01195	COG0640	Transcriptional regulator
GPY00_RS01205	COG3706	GGDEF domain
GPY00_RS01225	COG1946	Acyl-CoA thioesterase
GPY00_RS01230	COG1522	sequence-specific DNA binding
GPY00_RS01240	COG0616	signal peptide processing
GPY00_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
GPY00_RS01260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY00_RS01265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY00_RS01275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY00_RS01280	COG2832	Protein of unknown function (DUF454)
GPY00_RS01290	COG0745	RESPONSE REGULATOR receiver
GPY00_RS01295	COG0583	DNA-binding transcription factor activity
GPY00_RS01300	COG0778	Nitroreductase
GPY00_RS01305	COG1024	Enoyl-CoA hydratase
GPY00_RS01305	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY00_RS01310	COG0183	Belongs to the thiolase family
GPY00_RS01325	COG2067	long-chain fatty acid transport protein
GPY00_RS01335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY00_RS01340	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY00_RS01345	COG2982	Protein involved in outer membrane biogenesis
GPY00_RS01350	COG0572	uridine kinase
GPY00_RS01355	COG0489	protein tyrosine kinase activity
GPY00_RS01360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY00_RS01360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY00_RS01370	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY00_RS01380	COG4109	DRTGG domain
GPY00_RS01385	COG2199	diguanylate cyclase activity
GPY00_RS01390	COG0314	molybdopterin synthase activity
GPY00_RS01395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY00_RS01400	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY00_RS01405	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY00_RS01410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY00_RS01415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY00_RS01420	COG2198	Histidine kinase
GPY00_RS01425	COG2204	response regulator
GPY00_RS01430	COG0556	nucleotide-excision repair
GPY00_RS01440	COG4657	Part of a membrane complex involved in electron transport
GPY00_RS01445	COG2878	Part of a membrane complex involved in electron transport
GPY00_RS01450	COG4656	Part of a membrane complex involved in electron transport
GPY00_RS01455	COG4658	electron transport chain
GPY00_RS01460	COG4659	FMN binding
GPY00_RS01465	COG4660	Part of a membrane complex involved in electron transport
GPY00_RS01470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY00_RS01475	COG0346	lactoylglutathione lyase activity
GPY00_RS01490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY00_RS01495	COG2056	Na+-H+ antiporter family
GPY00_RS01500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY00_RS01505	COG1286	toxin biosynthetic process
GPY00_RS01510	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY00_RS01515	COG0285	dihydrofolate synthase activity
GPY00_RS01520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY00_RS01525	COG0101	tRNA pseudouridine synthase activity
GPY00_RS01535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY00_RS01540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY00_RS01540	COG1263	PTS System
GPY00_RS01540	COG2190	(PTS) system
GPY00_RS01545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY00_RS01550	COG1846	Transcriptional regulator
GPY00_RS01550	COG1940	carbohydrate kinase activity
GPY00_RS01555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY00_RS01555	COG4651	solute:proton antiporter activity
GPY00_RS01560	COG0367	asparagine synthase
GPY00_RS01575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY00_RS01580	COG0563	adenylate kinase activity
GPY00_RS01585	COG0326	Molecular chaperone. Has ATPase activity
GPY00_RS01590	COG3710	Transcriptional regulator
GPY00_RS01605	COG0622	Phosphoesterase
GPY00_RS01610	COG1090	epimerase
GPY00_RS01615	COG0300	oxidoreductase activity
GPY00_RS01625	COG3118	belongs to the thioredoxin family
GPY00_RS01630	COG0330	HflC and HflK could
GPY00_RS01635	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPY00_RS01640	COG0789	Transcriptional regulator
GPY00_RS01655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY00_RS01660	COG3115	cell septum assembly
GPY00_RS01665	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY00_RS01670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY00_RS01680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY00_RS01690	COG2190	(PTS) system
GPY00_RS01695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY00_RS01700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY00_RS01705	COG1702	phosphate starvation-inducible protein PhoH
GPY00_RS01710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY00_RS01715	COG4535	Mg2 and Co2 transporter CorC
GPY00_RS01720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY00_RS01725	COG2888	peptidyl-tyrosine sulfation
GPY00_RS01730	COG0495	leucyl-tRNA aminoacylation
GPY00_RS01735	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY00_RS01740	COG1466	dna polymerase III delta subunit
GPY00_RS01745	COG0799	negative regulation of ribosome biogenesis
GPY00_RS01750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY00_RS01755	COG0768	penicillin binding
GPY00_RS01760	COG0772	Belongs to the SEDS family
GPY00_RS01765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY00_RS01770	COG1686	Belongs to the peptidase S11 family
GPY00_RS01775	COG2921	Belongs to the UPF0250 family
GPY00_RS01780	COG0321	lipoyl(octanoyl) transferase activity
GPY00_RS01785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY00_RS01795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY00_RS01820	COG1596	polysaccharide export
GPY00_RS01830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY00_RS01860	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPY00_RS01870	COG0438	transferase activity, transferring glycosyl groups
GPY00_RS01880	COG1045	serine acetyltransferase
GPY00_RS01905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY00_RS01910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY00_RS01915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY00_RS01920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY00_RS01950	COG0366	Alpha amylase catalytic
GPY00_RS01955	COG1263	PTS System
GPY00_RS01955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY00_RS01960	COG1609	Transcriptional regulator
GPY00_RS01965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY00_RS01970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY00_RS01975	COG2011	ABC-type metal ion transport system permease component
GPY00_RS01980	COG1464	Belongs to the NlpA lipoprotein family
GPY00_RS01985	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY00_RS01995	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY00_RS01995	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY00_RS02005	COG3706	GGDEF domain
GPY00_RS02015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY00_RS02020	COG2363	Small membrane protein
GPY00_RS02025	COG0583	DNA-binding transcription factor activity
GPY00_RS02030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY00_RS02030	COG0301	tRNA thio-modification
GPY00_RS02040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY00_RS02045	COG1722	exodeoxyribonuclease VII activity
GPY00_RS02050	COG0142	geranyltranstransferase activity
GPY00_RS02055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY00_RS02060	COG0564	pseudouridine synthase activity
GPY00_RS02065	COG3098	single-species biofilm formation
GPY00_RS02080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY00_RS02090	COG1671	Belongs to the UPF0178 family
GPY00_RS02095	COG3385	transposase activity
GPY00_RS02100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY00_RS02105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY00_RS02110	COG0254	rRNA binding
GPY00_RS02115	COG1720	tRNA m6t6A37 methyltransferase activity
GPY00_RS02120	COG0442	prolyl-tRNA aminoacylation
GPY00_RS02140	COG3385	transposase activity
GPY00_RS02145	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY00_RS02145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY00_RS02155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY00_RS02160	COG0590	tRNA wobble adenosine to inosine editing
GPY00_RS02165	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY00_RS02200	COG0484	heat shock protein binding
GPY00_RS02205	COG0443	Heat shock 70 kDa protein
GPY00_RS02210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY00_RS02215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY00_RS02220	COG0497	DNA recombination
GPY00_RS02225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY00_RS02230	COG2914	Belongs to the UPF0125 (RnfH) family
GPY00_RS02235	COG2867	negative regulation of translational initiation
GPY00_RS02240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY00_RS02275	COG0739	heme binding
GPY00_RS02295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GPY00_RS02300	COG2207	Transcriptional regulator
GPY00_RS02310	COG1459	type II secretion system
GPY00_RS02315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY00_RS02335	COG4796	Type ii and iii secretion system protein
GPY00_RS02350	COG2165	general secretion pathway protein
GPY00_RS02360	COG3710	Transcriptional regulator
GPY00_RS02365	COG0840	transmembrane signaling receptor activity
GPY00_RS02370	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GPY00_RS02395	COG1012	belongs to the aldehyde dehydrogenase family
GPY00_RS02410	COG2003	Belongs to the UPF0758 family
GPY00_RS02485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY00_RS02490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY00_RS02495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY00_RS02500	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPY00_RS02505	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPY00_RS02510	COG3051	citrate lyase alpha subunit
GPY00_RS02515	COG2301	Belongs to the HpcH HpaI aldolase family
GPY00_RS02520	COG3052	prosthetic group binding
GPY00_RS02525	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPY00_RS02535	COG3630	sodium ion export across plasma membrane
GPY00_RS02540	COG0511	ligase activity, forming carbon-carbon bonds
GPY00_RS02540	COG5016	pyruvate
GPY00_RS02545	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY00_RS02555	COG4565	transcriptional regulatory protein
GPY00_RS02570	COG0583	DNA-binding transcription factor activity
GPY00_RS02575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY00_RS02580	COG1115	amino acid carrier protein
GPY00_RS02585	COG2977	Belongs to the P-Pant transferase superfamily
GPY00_RS02590	COG1120	ATPase activity
GPY00_RS02595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY00_RS02600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY00_RS02605	COG4592	Periplasmic binding protein
GPY00_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
GPY00_RS02620	COG1169	isochorismate synthase
GPY00_RS02625	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY00_RS02630	COG1535	isochorismatase
GPY00_RS02630	COG3433	isochorismatase activity
GPY00_RS02635	COG1584	GPR1 FUN34 yaaH family protein
GPY00_RS02645	COG0519	Catalyzes the synthesis of GMP from XMP
GPY00_RS02645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY00_RS02650	COG0517	IMP dehydrogenase activity
GPY00_RS02650	COG0516	GMP reductase activity
GPY00_RS02655	COG1570	exodeoxyribonuclease VII activity
GPY00_RS02670	COG1160	GTP binding
GPY00_RS02675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY00_RS02680	COG2976	Protein conserved in bacteria
GPY00_RS02685	COG0124	histidyl-tRNA synthetase
GPY00_RS02690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY00_RS02705	COG0105	UTP biosynthetic process
GPY00_RS02710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY00_RS02715	COG2975	iron-sulfur cluster assembly
GPY00_RS02720	COG0633	Ferredoxin
GPY00_RS02740	COG0822	iron-sulfur transferase activity
GPY00_RS02750	COG1959	2 iron, 2 sulfur cluster binding
GPY00_RS02760	COG0483	inositol monophosphate 1-phosphatase activity
GPY00_RS02765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY00_RS02770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY00_RS02775	COG1862	Preprotein translocase
GPY00_RS02780	COG0343	queuine tRNA-ribosyltransferase activity
GPY00_RS02785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY00_RS02790	COG0517	IMP dehydrogenase activity
GPY00_RS02800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY00_RS02805	COG0583	DNA-binding transcription factor activity
GPY00_RS02810	COG0450	alkyl hydroperoxide reductase
GPY00_RS02815	COG3142	Participates in the control of copper homeostasis
GPY00_RS02830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY00_RS02835	COG0581	inorganic phosphate transmembrane transporter activity
GPY00_RS02845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY00_RS02850	COG0248	Ppx GppA phosphatase
GPY00_RS02860	COG5002	protein histidine kinase activity
GPY00_RS02865	COG0745	RESPONSE REGULATOR receiver
GPY00_RS02870	COG2974	May be involved in recombination
GPY00_RS02880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY00_RS02925	COG0542	response to heat
GPY00_RS02935	COG0564	pseudouridine synthase activity
GPY00_RS02940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY00_RS02945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY00_RS02950	COG3385	transposase activity
GPY00_RS02955	COG0077	Prephenate dehydratase
GPY00_RS02955	COG1605	Chorismate mutase
GPY00_RS02960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY00_RS02965	COG5001	Diguanylate cyclase
GPY00_RS02970	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY00_RS02975	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY00_RS02985	COG0488	(ABC) transporter
GPY00_RS02995	COG0287	Prephenate dehydrogenase
GPY00_RS02995	COG1605	Chorismate mutase
GPY00_RS03000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY00_RS03005	COG3275	phosphorelay sensor kinase activity
GPY00_RS03010	COG3279	Response regulator of the LytR AlgR family
GPY00_RS03015	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY00_RS03020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY00_RS03025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY00_RS03040	COG1966	Carbon starvation protein
GPY00_RS03045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY00_RS03050	COG1047	Peptidyl-prolyl cis-trans
GPY00_RS03055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY00_RS03060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY00_RS03065	COG0196	riboflavin kinase activity
GPY00_RS03070	COG0728	peptidoglycan biosynthetic process
GPY00_RS03075	COG0268	Binds directly to 16S ribosomal RNA
GPY00_RS03080	COG0640	Transcriptional regulator
GPY00_RS03085	COG0583	DNA-binding transcription factor activity
GPY00_RS03090	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY00_RS03095	COG3385	transposase activity
GPY00_RS03100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY00_RS03105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY00_RS03110	COG0730	response to heat
GPY00_RS03115	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPY00_RS03120	COG0494	nUDIX hydrolase
GPY00_RS03125	COG3066	DNA modification
GPY00_RS03130	COG0667	Aldo Keto reductase
GPY00_RS03145	COG2204	response regulator
GPY00_RS03150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY00_RS03165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY00_RS03170	COG0513	Belongs to the DEAD box helicase family
GPY00_RS03175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY00_RS03200	COG3153	acetyltransferase
GPY00_RS03235	COG3385	transposase activity
GPY00_RS03240	COG4785	May be involved in cell division
GPY00_RS03245	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY00_RS03250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY00_RS03255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY00_RS03260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY00_RS03265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY00_RS03270	COG0195	Participates in both transcription termination and antitermination
GPY00_RS03275	COG0779	Required for maturation of 30S ribosomal subunits
GPY00_RS03290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY00_RS03295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY00_RS03300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY00_RS03305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY00_RS03310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY00_RS03315	COG1534	Rna-binding protein
GPY00_RS03320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY00_RS03325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY00_RS03330	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY00_RS03335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY00_RS03340	COG0739	heme binding
GPY00_RS03355	COG0316	Belongs to the HesB IscA family
GPY00_RS03360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY00_RS03370	COG0628	permease
GPY00_RS03375	COG2813	Specifically methylates the guanine in position
GPY00_RS03385	COG0747	negative chemotaxis
GPY00_RS03395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY00_RS03400	COG0444	Belongs to the ABC transporter superfamily
GPY00_RS03405	COG4608	Belongs to the ABC transporter superfamily
GPY00_RS03415	COG2971	BadF BadG BcrA BcrD
GPY00_RS03430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY00_RS03435	COG3842	ATPase activity
GPY00_RS03445	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY00_RS03450	COG0004	ammonium transporteR
GPY00_RS03455	COG0347	Belongs to the P(II) protein family
GPY00_RS03460	COG3112	Uncharacterised protein family (UPF0231)
GPY00_RS03465	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY00_RS03470	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY00_RS03475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY00_RS03480	COG1643	Atp-dependent helicase
GPY00_RS03490	COG1489	DNA binding
GPY00_RS03495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY00_RS03500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY00_RS03510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY00_RS03515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY00_RS03520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY00_RS03525	COG0842	Transport permease protein
GPY00_RS03530	COG1131	(ABC) transporter
GPY00_RS03535	COG0659	secondary active sulfate transmembrane transporter activity
GPY00_RS03540	COG0288	reversible hydration of carbon dioxide
GPY00_RS03555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY00_RS03560	COG3107	peptidoglycan biosynthetic process
GPY00_RS03565	COG0792	nuclease activity
GPY00_RS03570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY00_RS03575	COG2823	Periplasmic or secreted lipoprotein
GPY00_RS03580	COG2969	positive regulation of protein catabolic process
GPY00_RS03585	COG0625	glutathione transferase activity
GPY00_RS03590	COG2857	Cytochrome c1
GPY00_RS03595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY00_RS03600	COG0723	plastoquinol--plastocyanin reductase activity
GPY00_RS03605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY00_RS03610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY00_RS03615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY00_RS03625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY00_RS03630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY00_RS03635	COG0335	large ribosomal subunit rRNA binding
GPY00_RS03640	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY00_RS03645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY00_RS03650	COG0228	four-way junction DNA binding
GPY00_RS03655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY00_RS03660	COG4137	Cytochrome C assembly protein
GPY00_RS03665	COG4536	flavin adenine dinucleotide binding
GPY00_RS03670	COG1854	S-ribosylhomocysteine lyase activity
GPY00_RS03675	COG2918	glutathione biosynthetic process
GPY00_RS03680	COG0612	Peptidase, M16
GPY00_RS03685	COG1238	metal cluster binding
GPY00_RS03695	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY00_RS03700	COG0511	ligase activity, forming carbon-carbon bonds
GPY00_RS03700	COG5016	pyruvate
GPY00_RS03705	COG3630	sodium ion export across plasma membrane
GPY00_RS03745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPY00_RS03750	COG0527	aspartate kinase activity
GPY00_RS03755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY00_RS03760	COG2137	regulation of response to DNA damage stimulus
GPY00_RS03765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY00_RS03775	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPY00_RS03780	COG4208	sulfate ABC transporter
GPY00_RS03800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY00_RS03805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY00_RS03810	COG1388	LysM domain
GPY00_RS03810	COG4942	peptidase
GPY00_RS03815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY00_RS03820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY00_RS03825	COG0585	pseudouridine synthase activity
GPY00_RS03830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY00_RS03835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY00_RS03840	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY00_RS03845	COG1968	undecaprenyl-diphosphatase activity
GPY00_RS03850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY00_RS03855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY00_RS03860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY00_RS03870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY00_RS03875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY00_RS03880	COG1610	YqeY-like protein
GPY00_RS03885	COG0358	DNA primase activity
GPY00_RS03890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY00_RS03900	COG0582	viral genome integration into host DNA
GPY00_RS03950	COG3339	Conserved Protein
GPY00_RS03965	COG2003	Belongs to the UPF0758 family
GPY00_RS04045	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY00_RS04100	COG3501	Rhs element vgr protein
GPY00_RS04115	COG2207	Transcriptional regulator
GPY00_RS04130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY00_RS04135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY00_RS04140	COG1349	DNA-binding transcription factor activity
GPY00_RS04145	COG0469	pyruvate kinase activity
GPY00_RS04155	COG0583	DNA-binding transcription factor activity
GPY00_RS04160	COG1279	arginine transmembrane transporter activity
GPY00_RS04165	COG0668	transmembrane transport
GPY00_RS04175	COG0191	fructose-bisphosphate aldolase activity
GPY00_RS04180	COG0126	phosphoglycerate kinase activity
GPY00_RS04185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY00_RS04190	COG4771	TonB-dependent receptor
GPY00_RS04195	COG0583	DNA-binding transcription factor activity
GPY00_RS04200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY00_RS04205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY00_RS04210	COG3091	SprT-like family
GPY00_RS04215	COG2356	endonuclease I
GPY00_RS04220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY00_RS04225	COG0189	ligase activity
GPY00_RS04230	COG1678	Uncharacterized ACR, COG1678
GPY00_RS04235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY00_RS04240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY00_RS04260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY00_RS04265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY00_RS04270	COG0762	integral membrane protein
GPY00_RS04285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY00_RS04290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY00_RS04295	COG2066	Belongs to the glutaminase family
GPY00_RS04300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY00_RS04305	COG1194	a g-specific adenine glycosylase
GPY00_RS04310	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY00_RS04315	COG0741	lytic transglycosylase activity
GPY00_RS04370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY00_RS04375	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY00_RS04380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY00_RS04385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY00_RS04390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY00_RS04395	COG2967	ApaG domain
GPY00_RS04400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY00_RS04410	COG3610	response to peptide
GPY00_RS04415	COG2966	Psort location CytoplasmicMembrane, score
GPY00_RS04420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY00_RS04425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY00_RS04430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY00_RS04435	COG0142	geranyltranstransferase activity
GPY00_RS04440	COG0531	amino acid
GPY00_RS04445	COG0039	L-malate dehydrogenase activity
GPY00_RS04450	COG1438	arginine binding
GPY00_RS04465	COG0589	response to stress
GPY00_RS04485	COG2235	arginine
GPY00_RS04490	COG0312	modulator of DNA gyrase
GPY00_RS04495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY00_RS04500	COG3164	Protein of unknown function
GPY00_RS04505	COG1530	ribonuclease E activity
GPY00_RS04510	COG0424	maF-like protein
GPY00_RS04515	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY00_RS04520	COG1792	Involved in formation and maintenance of cell shape
GPY00_RS04525	COG1077	Cell shape determining protein MreB Mrl
GPY00_RS04570	COG1459	type II secretion system
GPY00_RS04575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY00_RS04585	COG3409	Peptidoglycan-binding domain 1 protein
GPY00_RS04585	COG3267	Type II secretory pathway component ExeA
GPY00_RS04610	COG2199	diguanylate cyclase activity
GPY00_RS04610	COG2200	EAL domain
GPY00_RS04615	COG0629	single-stranded DNA binding
GPY00_RS04630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY00_RS04640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY00_RS04645	COG0527	aspartate kinase activity
GPY00_RS04650	COG0646	methionine synthase
GPY00_RS04650	COG1410	methionine synthase
GPY00_RS04720	COG0175	sulfate reduction
GPY00_RS04725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY00_RS04730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY00_RS04755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY00_RS04760	COG0735	belongs to the Fur family
GPY00_RS04775	COG0166	Belongs to the GPI family
GPY00_RS04780	COG0432	Pfam Uncharacterised protein family UPF0047
GPY00_RS04785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY00_RS04790	COG0305	Participates in initiation and elongation during chromosome replication
GPY00_RS04800	COG1943	Transposase
GPY00_RS04805	COG0359	binds to the 23S rRNA
GPY00_RS04810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPY00_RS04815	COG2965	DNA replication, synthesis of RNA primer
GPY00_RS04820	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY00_RS04830	COG2906	2 iron, 2 sulfur cluster binding
GPY00_RS04835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY00_RS04840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY00_RS04845	COG0049	tRNA binding
GPY00_RS04850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPY00_RS04860	COG2923	Belongs to the DsrF TusC family
GPY00_RS04865	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY00_RS04870	COG2964	Protein conserved in bacteria
GPY00_RS04875	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY00_RS04885	COG2900	Belongs to the SlyX family
GPY00_RS04890	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY00_RS04895	COG0330	HflC and HflK could
GPY00_RS04900	COG0330	HflC and HflK could
GPY00_RS04905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY00_RS04910	COG1923	regulation of RNA biosynthetic process
GPY00_RS04915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY00_RS04920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY00_RS04930	COG0802	atpase or kinase
GPY00_RS04935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY00_RS04995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY00_RS05000	COG1162	GTPase activity
GPY00_RS05005	COG0688	phosphatidylethanolamine metabolic process
GPY00_RS05010	COG0471	metal ion transport
GPY00_RS05020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY00_RS05025	COG4942	peptidase
GPY00_RS05040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY00_RS05045	COG2816	NAD+ diphosphatase activity
GPY00_RS05050	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY00_RS05055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY00_RS05060	COG0085	RNA polymerase activity
GPY00_RS05065	COG0222	ribosome binding
GPY00_RS05070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY00_RS05075	COG0081	regulation of translation
GPY00_RS05080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY00_RS05085	COG0250	Participates in transcription elongation, termination and antitermination
GPY00_RS05090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY00_RS05095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY00_RS05120	COG1072	(Pantothenic acid kinase))
GPY00_RS05130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY00_RS05140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY00_RS05180	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY00_RS05190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY00_RS05195	COG3118	belongs to the thioredoxin family
GPY00_RS05200	COG0513	Belongs to the DEAD box helicase family
GPY00_RS05205	COG0248	Ppx GppA phosphatase
GPY00_RS05210	COG0784	Response regulator, receiver
GPY00_RS05210	COG2205	protein histidine kinase activity
GPY00_RS05215	COG2814	Major facilitator Superfamily
GPY00_RS05235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY00_RS05240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY00_RS05245	COG0511	ligase activity, forming carbon-carbon bonds
GPY00_RS05250	COG0439	Biotin carboxylase
GPY00_RS05260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY00_RS05265	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY00_RS05270	COG1609	Transcriptional regulator
GPY00_RS05275	COG0129	dihydroxy-acid dehydratase activity
GPY00_RS05280	COG3265	gluconokinase activity
GPY00_RS05290	COG0800	Aldolase
GPY00_RS05310	COG0840	transmembrane signaling receptor activity
GPY00_RS05315	COG1982	Orn Lys Arg decarboxylase major
GPY00_RS05320	COG0531	amino acid
GPY00_RS05325	COG3710	Transcriptional regulator
GPY00_RS05330	COG0789	Transcriptional regulator
GPY00_RS05340	COG0138	bifunctional purine biosynthesis protein purh
GPY00_RS05345	COG0151	Belongs to the GarS family
GPY00_RS05350	COG3385	transposase activity
GPY00_RS05360	COG0776	regulation of translation
GPY00_RS05365	COG1253	flavin adenine dinucleotide binding
GPY00_RS05375	COG3068	Protein conserved in bacteria
GPY00_RS05385	COG1573	uracil-dna glycosylase
GPY00_RS05390	COG0668	transmembrane transport
GPY00_RS05400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY00_RS05425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY00_RS05435	COG0438	transferase activity, transferring glycosyl groups
GPY00_RS05440	COG0438	transferase activity, transferring glycosyl groups
GPY00_RS05455	COG0367	asparagine synthase
GPY00_RS05470	COG2244	polysaccharide biosynthetic process
GPY00_RS05475	COG1213	nucleotidyl transferase
GPY00_RS05480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY00_RS05485	COG0574	Belongs to the PEP-utilizing enzyme family
GPY00_RS05485	COG3848	Pyruvate phosphate dikinase
GPY00_RS05510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPY00_RS05550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY00_RS05560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY00_RS05585	COG0859	PFAM glycosyl transferase family 9
GPY00_RS05595	COG1519	Transferase
GPY00_RS05625	COG2755	lipolytic protein G-D-S-L family
GPY00_RS05625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GPY00_RS05630	COG3642	lipopolysaccharide core region biosynthetic process
GPY00_RS05635	COG0859	PFAM glycosyl transferase family 9
GPY00_RS05640	COG0463	Glycosyl transferase, family 2
GPY00_RS05645	COG0859	PFAM glycosyl transferase family 9
GPY00_RS05650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY00_RS05655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY00_RS05665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY00_RS05670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY00_RS05685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY00_RS05695	COG1309	transcriptional regulator
GPY00_RS05700	COG1560	Kdo2-lipid A biosynthetic process
GPY00_RS05705	COG1560	Kdo2-lipid A biosynthetic process
GPY00_RS05710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY00_RS05715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY00_RS05720	COG1561	YicC-like family, N-terminal region
GPY00_RS05730	COG3385	transposase activity
GPY00_RS05735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY00_RS05735	COG1263	PTS System
GPY00_RS05740	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY00_RS05765	COG1120	ATPase activity
GPY00_RS05770	COG4774	siderophore transport
GPY00_RS05775	COG1132	(ABC) transporter
GPY00_RS05790	COG0514	ATP-dependent DNA helicase (RecQ)
GPY00_RS05795	COG2962	Rard protein
GPY00_RS05800	COG0405	Gamma-glutamyltransferase
GPY00_RS05810	COG1280	lysine exporter protein (LysE YggA)
GPY00_RS05815	COG0210	DNA helicase
GPY00_RS05825	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY00_RS05830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY00_RS05840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY00_RS05850	COG0747	negative chemotaxis
GPY00_RS05905	COG1309	transcriptional regulator
GPY00_RS05910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY00_RS05915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY00_RS05920	COG2960	long-chain fatty acid transporting porin activity
GPY00_RS05925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY00_RS05930	COG0583	DNA-binding transcription factor activity
GPY00_RS06000	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPY00_RS06005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY00_RS06010	COG1739	Uncharacterized protein family UPF0029
GPY00_RS06015	COG1024	Enoyl-CoA hydratase
GPY00_RS06015	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY00_RS06020	COG0183	Belongs to the thiolase family
GPY00_RS06025	COG0583	DNA-binding transcription factor activity
GPY00_RS06030	COG2814	Major facilitator Superfamily
GPY00_RS06040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY00_RS06045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY00_RS06050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY00_RS06055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY00_RS06060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY00_RS06065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY00_RS06075	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY00_RS06080	COG3312	ion transport
GPY00_RS06085	COG1475	DNA binding
GPY00_RS06090	COG1192	Involved in chromosome partitioning
GPY00_RS06095	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY00_RS06100	COG0445	tRNA wobble uridine modification
GPY00_RS06110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY00_RS06115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY00_RS06120	COG3385	transposase activity
GPY00_RS06125	COG0706	membrane insertase activity
GPY00_RS06130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY00_RS06135	COG0594	ribonuclease P activity
GPY00_RS06140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY00_RS06145	COG1126	abc transporter atp-binding protein
GPY00_RS06160	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY00_RS06165	COG0592	DNA-directed DNA polymerase activity
GPY00_RS06170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY00_RS06175	COG0187	DNA topoisomerase II activity
GPY00_RS06190	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY00_RS06195	COG3977	Valine--pyruvate aminotransferase
GPY00_RS06200	COG0751	glycine-tRNA ligase activity
GPY00_RS06205	COG0752	glycyl-tRNA synthetase alpha subunit
GPY00_RS06210	COG2119	membrane
GPY00_RS06220	COG0425	Belongs to the sulfur carrier protein TusA family
GPY00_RS06230	COG0604	alcohol dehydrogenase
GPY00_RS06240	COG0129	dihydroxy-acid dehydratase activity
GPY00_RS06245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY00_RS06260	COG0606	chelatase, subunit chli
GPY00_RS06265	COG0204	Acyl-transferase
GPY00_RS06270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY00_RS06275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY00_RS06285	COG3084	Protein conserved in bacteria
GPY00_RS06290	COG3385	transposase activity
GPY00_RS06300	COG4326	sporulation control protein
GPY00_RS06305	COG1272	protein, Hemolysin III
GPY00_RS06315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY00_RS06320	COG0569	domain protein
GPY00_RS06325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY00_RS06325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY00_RS06335	COG0242	peptide deformylase activity
GPY00_RS06340	COG1652	LysM domain
GPY00_RS06345	COG0758	DNA mediated transformation
GPY00_RS06350	COG2922	Belongs to the Smg family
GPY00_RS06355	COG0551	DNA topoisomerase type I activity
GPY00_RS06360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY00_RS06365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY00_RS06370	COG0009	L-threonylcarbamoyladenylate synthase
GPY00_RS06380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY00_RS06390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY00_RS06430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY00_RS06435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY00_RS06445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY00_RS06450	COG2104	thiamine diphosphate biosynthetic process
GPY00_RS06455	COG2022	thiamine diphosphate biosynthetic process
GPY00_RS06460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY00_RS06465	COG0006	proline dipeptidase activity
GPY00_RS06485	COG1522	sequence-specific DNA binding
GPY00_RS06490	COG5001	Diguanylate cyclase
GPY00_RS06490	COG5002	protein histidine kinase activity
GPY00_RS06495	COG0742	ribosomal rna small subunit methyltransferase
GPY00_RS06505	COG0697	spore germination
GPY00_RS06510	COG0589	response to stress
GPY00_RS06520	COG1528	Iron-storage protein
GPY00_RS06530	COG2081	HI0933 family
GPY00_RS06540	COG1322	Protein conserved in bacteria
GPY00_RS06545	COG2226	methyltransferase
GPY00_RS06555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY00_RS06560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY00_RS06565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY00_RS06570	COG0805	protein transport
GPY00_RS06580	COG1858	cytochrome C peroxidase
GPY00_RS06585	COG0534	Mate efflux family protein
GPY00_RS06595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY00_RS06600	COG2937	Belongs to the GPAT DAPAT family
GPY00_RS06605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY00_RS06610	COG3161	chorismate lyase activity
GPY00_RS06620	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY00_RS06625	COG0840	transmembrane signaling receptor activity
GPY00_RS06635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY00_RS06645	COG0084	hydrolase, TatD family'
GPY00_RS06660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY00_RS06660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY00_RS06665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY00_RS06680	COG3078	GTPase activator activity
GPY00_RS06690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY00_RS06695	COG3071	HemY protein
GPY00_RS06700	COG2959	enzyme of heme biosynthesis
GPY00_RS06705	COG1587	Uroporphyrinogen-III synthase
GPY00_RS06710	COG0181	hydroxymethylbilane synthase activity
GPY00_RS06720	COG3072	Adenylate cyclase
GPY00_RS06725	COG1965	Belongs to the frataxin family
GPY00_RS06735	COG0019	diaminopimelate decarboxylase activity
GPY00_RS06740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY00_RS06750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY00_RS06755	COG1011	Hydrolase
GPY00_RS06775	COG0561	phosphatase activity
GPY00_RS06780	COG2267	carboxylic ester hydrolase activity
GPY00_RS06785	COG1280	lysine exporter protein (LysE YggA)
GPY00_RS06790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY00_RS06795	COG0783	Belongs to the Dps family
GPY00_RS06825	COG0742	ribosomal rna small subunit methyltransferase
GPY00_RS06830	COG0552	protein localization to endoplasmic reticulum
GPY00_RS06835	COG2884	Cell division ATP-binding protein ftsE
GPY00_RS06840	COG2177	Part of the ABC transporter FtsEX involved in
GPY00_RS06845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY00_RS06850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY00_RS06865	COG3385	transposase activity
GPY00_RS06900	COG0328	RNA-DNA hybrid ribonuclease activity
GPY00_RS06930	COG1479	Protein of unknown function DUF262
GPY00_RS06965	COG2003	Belongs to the UPF0758 family
GPY00_RS06995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY00_RS07005	COG1404	Belongs to the peptidase S8 family
GPY00_RS07010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY00_RS07080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY00_RS07085	COG5001	Diguanylate cyclase
GPY00_RS07085	COG3300	MHYT domain
GPY00_RS07095	COG3852	Histidine kinase
GPY00_RS07105	COG0174	glutamine synthetase
GPY00_RS07120	COG1660	Displays ATPase and GTPase activities
GPY00_RS07130	COG1490	D-aminoacyl-tRNA deacylase activity
GPY00_RS07135	COG0456	acetyltransferase
GPY00_RS07145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY00_RS07150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY00_RS07155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY00_RS07160	COG3031	protein transport across the cell outer membrane
GPY00_RS07170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY00_RS07175	COG1459	type II secretion system
GPY00_RS07180	COG2165	general secretion pathway protein
GPY00_RS07185	COG2165	general secretion pathway protein
GPY00_RS07190	COG2165	general secretion pathway protein
GPY00_RS07195	COG4795	General secretion pathway protein
GPY00_RS07200	COG3156	type II secretion system protein K
GPY00_RS07205	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY00_RS07210	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY00_RS07220	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY00_RS07225	COG0494	nUDIX hydrolase
GPY00_RS07230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY00_RS07230	COG0316	Belongs to the HesB IscA family
GPY00_RS07235	COG1040	competence protein
GPY00_RS07240	COG0596	Alpha beta hydrolase
GPY00_RS07250	COG2183	response to ionizing radiation
GPY00_RS07255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY00_RS07260	COG2199	diguanylate cyclase activity
GPY00_RS07265	COG0745	RESPONSE REGULATOR receiver
GPY00_RS07275	COG2233	PERMEase
GPY00_RS07280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY00_RS07285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY00_RS07290	COG1758	RNA polymerase activity
GPY00_RS07295	COG0194	GDP metabolic process
GPY00_RS07300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY00_RS07305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY00_RS07315	COG3263	regulation of cellular component size
GPY00_RS07325	COG4232	protein-disulfide reductase activity
GPY00_RS07340	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY00_RS07345	COG1027	Aspartate ammonia-lyase
GPY00_RS07350	COG3706	GGDEF domain
GPY00_RS07355	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY00_RS07360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY00_RS07370	COG2205	protein histidine kinase activity
GPY00_RS07375	COG0745	RESPONSE REGULATOR receiver
GPY00_RS07385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY00_RS07390	COG0205	6-phosphofructokinase activity
GPY00_RS07395	COG1494	fructose-1,6-bisphosphatase
GPY00_RS07400	COG3074	FtsZ-dependent cytokinesis
GPY00_RS07405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY00_RS07410	COG3385	transposase activity
GPY00_RS07415	COG0460	homoserine dehydrogenase
GPY00_RS07415	COG0527	aspartate kinase activity
GPY00_RS07420	COG0626	cystathionine gamma-synthase activity
GPY00_RS07425	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPY00_RS07430	COG0281	malic enzyme
GPY00_RS07435	COG0254	rRNA binding
GPY00_RS07440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY00_RS07445	COG1609	Transcriptional regulator
GPY00_RS07450	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY00_RS07455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY00_RS07460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY00_RS07465	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY00_RS07470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY00_RS07480	COG0149	triose-phosphate isomerase activity
GPY00_RS07505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY00_RS07510	COG0459	protein refolding
GPY00_RS07520	COG1509	lysine 2,3-aminomutase activity
GPY00_RS07525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY00_RS07530	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY00_RS07535	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY00_RS07540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY00_RS07545	COG1053	succinate dehydrogenase
GPY00_RS07550	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY00_RS07555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY00_RS07560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY00_RS07565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY00_RS07570	COG1045	serine acetyltransferase
GPY00_RS07580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY00_RS07585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY00_RS07590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY00_RS07595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY00_RS07600	COG0137	argininosuccinate synthase activity
GPY00_RS07605	COG0165	Argininosuccinate lyase
GPY00_RS07615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY00_RS07620	COG0678	peroxiredoxin activity
GPY00_RS07620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY00_RS07630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY00_RS07660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY00_RS07665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY00_RS07675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY00_RS07680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY00_RS07685	COG0546	phosphoglycolate phosphatase activity
GPY00_RS07690	COG0180	Tryptophanyl-tRNA synthetase
GPY00_RS07705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY00_RS07715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY00_RS07735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY00_RS07740	COG3954	Phosphoribulokinase
GPY00_RS07750	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY00_RS07760	COG0488	(ABC) transporter
GPY00_RS07765	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY00_RS07780	COG1047	Peptidyl-prolyl cis-trans
GPY00_RS07790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY00_RS07795	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY00_RS07800	COG3083	sulfuric ester hydrolase activity
GPY00_RS07805	COG0557	exoribonuclease II activity
GPY00_RS07810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY00_RS07815	COG0051	transcription antitermination factor activity, RNA binding
GPY00_RS07820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY00_RS07825	COG0088	Forms part of the polypeptide exit tunnel
GPY00_RS07830	COG0089	rRNA binding
GPY00_RS07835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY00_RS07840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY00_RS07845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY00_RS07850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY00_RS07855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPY00_RS07860	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY00_RS07865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY00_RS07870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY00_RS07875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY00_RS07880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY00_RS07885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY00_RS07890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY00_RS07895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY00_RS07900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY00_RS07905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPY00_RS07910	COG1841	ribosomal large subunit assembly
GPY00_RS07915	COG0200	Binds to the 23S rRNA
GPY00_RS07920	COG0201	protein transport
GPY00_RS07930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY00_RS07935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY00_RS07940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY00_RS07945	COG0202	RNA polymerase activity
GPY00_RS07950	COG0203	ribosomal protein L17
GPY00_RS07960	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY00_RS07965	COG3266	domain, Protein
GPY00_RS07965	COG3061	Opacity-associated protein A
GPY00_RS07970	COG0697	spore germination
GPY00_RS07975	COG2153	protein acetylation
GPY00_RS07980	COG0513	Belongs to the DEAD box helicase family
GPY00_RS07990	COG0737	Belongs to the 5'-nucleotidase family
GPY00_RS07995	COG1648	precorrin-2 dehydrogenase activity
GPY00_RS07995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY00_RS08000	COG0175	sulfate reduction
GPY00_RS08005	COG2895	sulfate adenylyltransferase (ATP) activity
GPY00_RS08010	COG0529	Catalyzes the synthesis of activated sulfate
GPY00_RS08030	COG1136	(ABC) transporter
GPY00_RS08045	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY00_RS08050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY00_RS08055	COG0729	surface antigen
GPY00_RS08065	COG2105	PFAM AIG2 family protein
GPY00_RS08070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY00_RS08075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY00_RS08080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY00_RS08085	COG0163	prenyltransferase activity
GPY00_RS08090	COG4143	(ABC) transporter
GPY00_RS08095	COG1178	ABC-type Fe3 transport system permease component
GPY00_RS08100	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY00_RS08105	COG3028	Belongs to the UPF0307 family
GPY00_RS08110	COG0312	modulator of DNA gyrase
GPY00_RS08115	COG2239	Acts as a magnesium transporter
GPY00_RS08120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY00_RS08130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY00_RS08135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY00_RS08145	COG1137	ATPase activity
GPY00_RS08150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY00_RS08165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY00_RS08165	COG0517	IMP dehydrogenase activity
GPY00_RS08175	COG1127	ABC transporter
GPY00_RS08180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY00_RS08185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY00_RS08190	COG2854	intermembrane phospholipid transfer
GPY00_RS08200	COG5007	Belongs to the BolA IbaG family
GPY00_RS08205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY00_RS08210	COG0204	Acyl-transferase
GPY00_RS08220	COG0251	oxidation-reduction process
GPY00_RS08225	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY00_RS08230	COG0540	Belongs to the ATCase OTCase family
GPY00_RS08235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY00_RS08240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY00_RS08245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY00_RS08250	COG0564	pseudouridine synthase activity
GPY00_RS08260	COG4269	membrane
GPY00_RS08270	COG0525	valine-tRNA ligase activity
GPY00_RS08275	COG2927	DNA polymerase III (CHI subunit)
GPY00_RS08280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY00_RS08285	COG0795	lipopolysaccharide-transporting ATPase activity
GPY00_RS08290	COG0795	lipopolysaccharide-transporting ATPase activity
GPY00_RS08310	COG3437	response regulator, receiver
GPY00_RS08355	COG0066	3-isopropylmalate dehydratase activity
GPY00_RS08360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY00_RS08365	COG0473	3-isopropylmalate dehydrogenase activity
GPY00_RS08370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY00_RS08390	COG0583	DNA-binding transcription factor activity
GPY00_RS08395	COG1022	Amp-dependent synthetase and ligase
GPY00_RS08400	COG0028	Belongs to the TPP enzyme family
GPY00_RS08405	COG0440	acetolactate synthase activity
GPY00_RS08410	COG3385	transposase activity
GPY00_RS08420	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY00_RS08425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY00_RS08435	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY00_RS08445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY00_RS08450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY00_RS08465	COG0354	folic acid binding
GPY00_RS08470	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY00_RS08480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY00_RS08485	COG1595	DNA-templated transcription, initiation
GPY00_RS08490	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPY00_RS08495	COG3026	antisigma factor binding
GPY00_RS08500	COG3086	response to oxidative stress
GPY00_RS08505	COG0481	GTPase activity
GPY00_RS08510	COG0681	Belongs to the peptidase S26 family
GPY00_RS08515	COG0571	ribonuclease III activity
GPY00_RS08520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY00_RS08525	COG1381	Involved in DNA repair and RecF pathway recombination
GPY00_RS08530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY00_RS08535	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY00_RS08560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY00_RS08565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY00_RS08570	COG3956	TIGRFAM MazG family protein
GPY00_RS08575	COG0504	CTP synthase activity
GPY00_RS08580	COG0148	phosphopyruvate hydratase activity
GPY00_RS08585	COG0617	tRNA 3'-terminal CCA addition
GPY00_RS08590	COG3409	Peptidoglycan-binding domain 1 protein
GPY00_RS08590	COG3267	Type II secretory pathway component ExeA
GPY00_RS08600	COG4991	sh3 domain protein
GPY00_RS08605	COG0306	phosphate transporter
GPY00_RS08610	COG1392	Phosphate transport regulator
GPY00_RS08615	COG3025	triphosphatase activity
GPY00_RS08625	COG0840	transmembrane signaling receptor activity
GPY00_RS08630	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY00_RS08640	COG1538	Outer membrane efflux protein
GPY00_RS08645	COG0494	nUDIX hydrolase
GPY00_RS08650	COG3151	Protein conserved in bacteria
GPY00_RS08660	COG3150	esterase
GPY00_RS08665	COG0187	DNA topoisomerase II activity
GPY00_RS08670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY00_RS08675	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY00_RS08680	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY00_RS08685	COG0237	dephospho-CoA kinase activity
GPY00_RS08695	COG1459	type II secretion system
GPY00_RS08700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY00_RS08725	COG0716	FMN binding
GPY00_RS08730	COG4974	Belongs to the 'phage' integrase family
GPY00_RS08735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY00_RS08740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY00_RS08745	COG2186	Transcriptional regulator
GPY00_RS08750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY00_RS08755	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY00_RS08760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY00_RS08770	COG0275	rRNA processing
GPY00_RS08775	COG3116	cell division
GPY00_RS08780	COG0768	penicillin binding
GPY00_RS08785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY00_RS08790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY00_RS08795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY00_RS08800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY00_RS08805	COG0772	Belongs to the SEDS family
GPY00_RS08810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY00_RS08815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY00_RS08820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY00_RS08825	COG0849	cell division
GPY00_RS08830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY00_RS08835	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY00_RS08845	COG0653	protein targeting
GPY00_RS08850	COG0494	nUDIX hydrolase
GPY00_RS08855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY00_RS08865	COG0505	Belongs to the CarA family
GPY00_RS08870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY00_RS08895	COG0730	response to heat
GPY00_RS08900	COG0583	DNA-binding transcription factor activity
GPY00_RS08905	COG2860	membrane
GPY00_RS08910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY00_RS08920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY00_RS08930	COG0493	'glutamate synthase
GPY00_RS08935	COG0070	glutamate synthase
GPY00_RS08935	COG0069	glutamate synthase activity
GPY00_RS08935	COG0067	glutamate synthase
GPY00_RS08945	COG0069	glutamate synthase activity
GPY00_RS08945	COG0070	glutamate synthase
GPY00_RS08945	COG0067	glutamate synthase
GPY00_RS08950	COG1242	4 iron, 4 sulfur cluster binding
GPY00_RS08955	COG2203	Gaf domain
GPY00_RS08955	COG5001	Diguanylate cyclase
GPY00_RS08955	COG4251	negative regulation of phosphorylation
GPY00_RS08955	COG3706	GGDEF domain
GPY00_RS08960	COG5002	protein histidine kinase activity
GPY00_RS08960	COG0784	Response regulator, receiver
GPY00_RS08960	COG2198	Histidine kinase
GPY00_RS08965	COG0745	RESPONSE REGULATOR receiver
GPY00_RS08975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY00_RS08995	COG0083	homoserine kinase activity
GPY00_RS09000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY00_RS09005	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY00_RS09010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY00_RS09015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY00_RS09030	COG1115	amino acid carrier protein
GPY00_RS09045	COG0084	hydrolase, TatD family'
GPY00_RS09050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY00_RS09060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY00_RS09065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY00_RS09070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY00_RS09075	COG0813	purine-nucleoside phosphorylase activity
GPY00_RS09085	COG0560	Phosphoserine phosphatase
GPY00_RS09095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY00_RS09100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY00_RS09105	COG1022	Amp-dependent synthetase and ligase
GPY00_RS09120	COG3250	beta-galactosidase activity
GPY00_RS09125	COG1609	Transcriptional regulator
GPY00_RS09130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY00_RS09145	COG0569	domain protein
GPY00_RS09145	COG0189	ligase activity
GPY00_RS09150	COG0456	acetyltransferase
GPY00_RS09160	COG1943	Transposase
GPY00_RS09170	COG2171	N-acyltransferase activity
GPY00_RS09175	COG3141	response to X-ray
GPY00_RS09190	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY00_RS09195	COG1074	ATP-dependent DNA helicase activity
GPY00_RS09200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY00_RS09210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY00_RS09210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY00_RS09220	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY00_RS09225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY00_RS09230	COG2166	iron-sulfur cluster assembly
GPY00_RS09235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY00_RS09240	COG0693	protein deglycase activity
GPY00_RS09245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY00_RS09250	COG3248	Nucleoside-binding outer membrane protein
GPY00_RS09260	COG1595	DNA-templated transcription, initiation
GPY00_RS09270	COG2211	Major facilitator Superfamily
GPY00_RS09280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY00_RS09290	COG2813	Specifically methylates the guanine in position
GPY00_RS09295	COG0271	Belongs to the BolA IbaG family
GPY00_RS09300	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY00_RS09305	COG1805	sodium ion transport
GPY00_RS09310	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY00_RS09315	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY00_RS09320	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY00_RS09325	COG2871	sodium ion transport
GPY00_RS09330	COG1477	protein flavinylation
GPY00_RS09340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY00_RS09350	COG3706	GGDEF domain
GPY00_RS09355	COG0733	neurotransmitter:sodium symporter activity
GPY00_RS09365	COG0189	ligase activity
GPY00_RS09370	COG0189	ligase activity
GPY00_RS09370	COG4067	protein conserved in archaea
GPY00_RS09375	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY00_RS09380	COG2252	PERMEase
GPY00_RS09385	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY00_RS09400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY00_RS09405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY00_RS09410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY00_RS09415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY00_RS09415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY00_RS09430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPY00_RS09435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY00_RS09440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY00_RS09445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY00_RS09455	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY00_RS09460	COG0024	Methionine aminopeptidase
GPY00_RS09465	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY00_RS09470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY00_RS09475	COG0528	UMP kinase activity
GPY00_RS09480	COG0233	cytoplasmic translational termination
GPY00_RS09485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY00_RS09490	COG0575	Belongs to the CDS family
GPY00_RS09495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY00_RS09500	COG0750	zinc metalloprotease
GPY00_RS09510	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY00_RS09515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY00_RS09520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY00_RS09525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY00_RS09530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY00_RS09535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY00_RS09540	COG0587	DNA-directed DNA polymerase activity
GPY00_RS09545	COG0825	malonyl-CoA metabolic process
GPY00_RS09555	COG0037	tRNA processing
GPY00_RS09565	COG3479	Phenolic acid decarboxylase
GPY00_RS09570	COG0347	Belongs to the P(II) protein family
GPY00_RS09580	COG0741	lytic transglycosylase activity
GPY00_RS09580	COG1388	LysM domain
GPY00_RS09585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY00_RS09590	COG2226	methyltransferase
GPY00_RS09595	COG0328	RNA-DNA hybrid ribonuclease activity
GPY00_RS09600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY00_RS09610	COG1960	acyl-CoA dehydrogenase activity
GPY00_RS09615	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY00_RS09620	COG0121	glutamine amidotransferase
GPY00_RS09625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY00_RS09630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY00_RS09635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY00_RS09640	COG3706	GGDEF domain
GPY00_RS09645	COG1187	pseudouridine synthase activity
GPY00_RS09650	COG2840	Smr protein MutS2
GPY00_RS09680	COG2608	mercury ion transmembrane transporter activity
GPY00_RS09680	COG2217	Heavy metal translocating P-type atpase
GPY00_RS09685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY00_RS09700	COG1629	transport
GPY00_RS09700	COG4774	siderophore transport
GPY00_RS09705	COG2375	cellular response to nickel ion
GPY00_RS09710	COG2226	methyltransferase
GPY00_RS09710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY00_RS09710	COG3433	isochorismatase activity
GPY00_RS09745	COG0784	Response regulator, receiver
GPY00_RS09745	COG0835	chemotaxis
GPY00_RS09750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY00_RS09755	COG1815	bacterial-type flagellum-dependent cell motility
GPY00_RS09760	COG1558	bacterial-type flagellum-dependent cell motility
GPY00_RS09765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY00_RS09770	COG1749	Flagellar hook protein flgE
GPY00_RS09775	COG4787	bacterial-type flagellum-dependent cell motility
GPY00_RS09780	COG4786	Flagellar basal body rod
GPY00_RS09785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY00_RS09790	COG1706	bacterial-type flagellum-dependent cell motility
GPY00_RS09795	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY00_RS09795	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY00_RS09815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY00_RS09820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY00_RS09905	COG0012	GTP binding
GPY00_RS09910	COG0193	aminoacyl-tRNA hydrolase activity
GPY00_RS09915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY00_RS09920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY00_RS09925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY00_RS09930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY00_RS09935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY00_RS09940	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY00_RS09945	COG3094	Invasion gene expression up-regulator, SirB
GPY00_RS09950	COG2912	Transglutaminase-like superfamily
GPY00_RS09955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY00_RS09960	COG0737	Belongs to the 5'-nucleotidase family
GPY00_RS09965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY00_RS09970	COG2233	PERMEase
GPY00_RS09990	COG1393	Belongs to the ArsC family
GPY00_RS09995	COG4783	chaperone-mediated protein folding
GPY00_RS10015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY00_RS10025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY00_RS10030	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY00_RS10040	COG1876	peptidase activity
GPY00_RS10045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY00_RS10050	COG1393	Belongs to the ArsC family
GPY00_RS10070	COG2837	iron assimilation
GPY00_RS10075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY00_RS10080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY00_RS10085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY00_RS10090	COG1334	flagellar protein FlaG
GPY00_RS10095	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY00_RS10105	COG1516	flagellar protein fliS
GPY00_RS10110	COG2204	response regulator
GPY00_RS10115	COG4191	Histidine kinase
GPY00_RS10120	COG2204	response regulator
GPY00_RS10125	COG1677	Flagellar hook-basal body complex protein FliE
GPY00_RS10135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY00_RS10140	COG1317	bacterial-type flagellum organization
GPY00_RS10165	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY00_RS10190	COG1987	bacterial-type flagellum assembly
GPY00_RS10195	COG1684	flagellar biosynthetic protein fliR
GPY00_RS10210	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY00_RS10215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY00_RS10220	COG2860	membrane
GPY00_RS10225	COG3101	peptidyl-lysine hydroxylation
GPY00_RS10235	COG0431	NADPH-dependent FMN reductase
GPY00_RS10240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY00_RS10240	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY00_RS10245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY00_RS10250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY00_RS10255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY00_RS10260	COG0735	belongs to the Fur family
GPY00_RS10270	COG0583	DNA-binding transcription factor activity
GPY00_RS10295	COG0596	Alpha beta hydrolase
GPY00_RS10300	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY00_RS10305	COG0033	Phosphoglucomutase
GPY00_RS10315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY00_RS10320	COG0372	Belongs to the citrate synthase family
GPY00_RS10325	COG2009	succinate dehydrogenase
GPY00_RS10330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY00_RS10335	COG1053	succinate dehydrogenase
GPY00_RS10345	COG0567	Dehydrogenase, E1 component
GPY00_RS10350	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY00_RS10355	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY00_RS10365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY00_RS10370	COG1121	(ABC) transporter
GPY00_RS10375	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY00_RS10380	COG4977	sequence-specific DNA binding
GPY00_RS10385	COG1918	ferrous iron import across plasma membrane
GPY00_RS10405	COG0018	arginyl-trna synthetase
GPY00_RS10415	COG1025	Belongs to the peptidase M16 family
GPY00_RS10420	COG2062	phosphohistidine phosphatase, SixA
GPY00_RS10435	COG0455	bacterial-type flagellum organization
GPY00_RS10450	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY00_RS10455	COG2198	Histidine kinase
GPY00_RS10455	COG0643	Histidine kinase
GPY00_RS10460	COG2201	protein-glutamate methylesterase activity
GPY00_RS10465	COG1192	Involved in chromosome partitioning
GPY00_RS10475	COG0835	chemotaxis
GPY00_RS10485	COG4133	protoheme IX ABC transporter activity
GPY00_RS10490	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY00_RS10495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY00_RS10505	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY00_RS10510	COG1138	Cytochrome C-type biogenesis protein
GPY00_RS10515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY00_RS10520	COG3088	subunit of a heme lyase
GPY00_RS10520	COG4235	cytochrome complex assembly
GPY00_RS10530	COG2853	Lipoprotein
GPY00_RS10550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY00_RS10555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY00_RS10560	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY00_RS10575	COG3083	sulfuric ester hydrolase activity
GPY00_RS10585	COG3081	Nucleoid-associated protein
GPY00_RS10595	COG1757	Na H antiporter
GPY00_RS10600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY00_RS10605	COG2095	MarC family integral membrane protein
GPY00_RS10610	COG1454	alcohol dehydrogenase
GPY00_RS10610	COG1012	belongs to the aldehyde dehydrogenase family
GPY00_RS10620	COG0659	secondary active sulfate transmembrane transporter activity
GPY00_RS10625	COG1530	ribonuclease E activity
GPY00_RS10630	COG0564	pseudouridine synthase activity
GPY00_RS10635	COG0424	maF-like protein
GPY00_RS10670	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY00_RS10675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPY00_RS10680	COG0416	fatty acid biosynthetic process
GPY00_RS10685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY00_RS10690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPY00_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
GPY00_RS10700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY00_RS10705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY00_RS10710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY00_RS10715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY00_RS10720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY00_RS10730	COG0084	hydrolase, TatD family'
GPY00_RS10735	COG1263	PTS System
GPY00_RS10735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY00_RS10750	COG0733	neurotransmitter:sodium symporter activity
GPY00_RS10765	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY00_RS10775	COG1940	carbohydrate kinase activity
GPY00_RS10780	COG0835	chemotaxis
GPY00_RS10780	COG0784	Response regulator, receiver
GPY00_RS10795	COG2226	methyltransferase
GPY00_RS10805	COG0676	glucose-6-phosphate 1-epimerase activity
GPY00_RS10810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY00_RS10815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY00_RS10825	COG3139	Protein of unknown function (DUF1315)
GPY00_RS10830	COG0252	asparaginase activity
GPY00_RS10835	COG0616	signal peptide processing
GPY00_RS10840	COG1902	pentaerythritol trinitrate reductase activity
GPY00_RS10840	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY00_RS10845	COG0788	formyltetrahydrofolate deformylase activity
GPY00_RS10855	COG1199	ATP-dependent helicase activity
GPY00_RS10860	COG1214	PFAM Peptidase M22, glycoprotease
GPY00_RS10875	COG2267	carboxylic ester hydrolase activity
GPY00_RS10880	COG0318	PFAM AMP-dependent synthetase and ligase
GPY00_RS10885	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY00_RS10900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY00_RS10905	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY00_RS10910	COG0436	Aminotransferase
GPY00_RS10915	COG1169	isochorismate synthase
GPY00_RS10920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY00_RS10925	COG0596	Alpha beta hydrolase
GPY00_RS10935	COG1441	menaquinone biosynthetic process
GPY00_RS10945	COG3135	benzoate transporter
GPY00_RS10970	COG3015	lipoprotein NlpE involved in copper resistance
GPY00_RS10975	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY00_RS10980	COG2894	cell division
GPY00_RS10985	COG0850	regulation of cytokinetic process
GPY00_RS10990	COG3100	YcgL domain-containing protein
GPY00_RS10995	COG2951	lytic endotransglycosylase activity
GPY00_RS11005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY00_RS11010	COG3469	chitinase activity
GPY00_RS11010	COG3325	Belongs to the glycosyl hydrolase 18 family
GPY00_RS11015	COG3005	denitrification pathway
GPY00_RS11020	COG0243	molybdopterin cofactor binding
GPY00_RS11040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY00_RS11050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY00_RS11085	COG4589	Belongs to the CDS family
GPY00_RS11095	COG3300	MHYT domain
GPY00_RS11095	COG5001	Diguanylate cyclase
GPY00_RS11110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY00_RS11115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY00_RS11120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY00_RS11125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY00_RS11135	COG4191	Histidine kinase
GPY00_RS11145	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY00_RS11155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY00_RS11160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY00_RS11165	COG0776	regulation of translation
GPY00_RS11170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY00_RS11175	COG1555	photosystem II stabilization
GPY00_RS11180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY00_RS11185	COG0539	negative regulation of cytoplasmic translation
GPY00_RS11190	COG0776	regulation of translation
GPY00_RS11195	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY00_RS11200	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY00_RS11205	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY00_RS11220	COG0583	DNA-binding transcription factor activity
GPY00_RS11230	COG0686	Belongs to the AlaDH PNT family
GPY00_RS11245	COG1674	ftsk spoiiie
GPY00_RS11250	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY00_RS11255	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY00_RS11260	COG2186	Transcriptional regulator
GPY00_RS11275	COG0537	adenosine 5'-monophosphoramidase activity
GPY00_RS11305	COG1252	NADH dehydrogenase
GPY00_RS11325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY00_RS11335	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY00_RS11340	COG1136	(ABC) transporter
GPY00_RS11345	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY00_RS11360	COG2333	competence protein COMEC
GPY00_RS11360	COG0658	competence protein
GPY00_RS11365	COG1132	(ABC) transporter
GPY00_RS11370	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY00_RS11380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY00_RS11385	COG2719	SpoVR family
GPY00_RS11390	COG2718	Belongs to the UPF0229 family
GPY00_RS11395	COG2766	serine protein kinase
GPY00_RS11400	COG3013	Belongs to the UPF0304 family
GPY00_RS11410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY00_RS11415	COG0840	transmembrane signaling receptor activity
GPY00_RS11425	COG1882	Formate acetyltransferase
GPY00_RS11445	COG4215	(ABC) transporter
GPY00_RS11450	COG4160	amino acid transport
GPY00_RS11455	COG0708	Exodeoxyribonuclease III
GPY00_RS11465	COG3923	Primosomal replication protein n
GPY00_RS11470	COG0730	response to heat
GPY00_RS11475	COG1199	ATP-dependent helicase activity
GPY00_RS11480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY00_RS11485	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY00_RS11495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY00_RS11500	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY00_RS11505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY00_RS11510	COG0215	cysteine-tRNA ligase activity
GPY00_RS11515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY00_RS11520	COG0632	four-way junction helicase activity
GPY00_RS11525	COG2255	four-way junction helicase activity
GPY00_RS11530	COG1271	oxidase subunit
GPY00_RS11535	COG1294	oxidase, subunit
GPY00_RS11540	COG4890	Cyd operon protein YbgT
GPY00_RS11545	COG3790	cyd operon protein YbgE
GPY00_RS11550	COG0824	Thioesterase
GPY00_RS11555	COG0811	peptide transport
GPY00_RS11570	COG0823	Involved in the tonB-independent uptake of proteins
GPY00_RS11575	COG2885	chlorophyll binding
GPY00_RS11585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY00_RS11595	COG5002	protein histidine kinase activity
GPY00_RS11595	COG0784	Response regulator, receiver
GPY00_RS11605	COG1482	cell wall glycoprotein biosynthetic process
GPY00_RS11610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY00_RS11610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY00_RS11610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY00_RS11615	COG2207	Transcriptional regulator
GPY00_RS11625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY00_RS11630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY00_RS11635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY00_RS11650	COG3284	Transcriptional regulator
GPY00_RS11655	COG4628	conserved protein (DUF2132)
GPY00_RS11665	COG0415	Belongs to the DNA photolyase family
GPY00_RS11690	COG4409	exo-alpha-(2->6)-sialidase activity
GPY00_RS11695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY00_RS11700	COG1940	carbohydrate kinase activity
GPY00_RS11705	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPY00_RS11715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY00_RS11720	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY00_RS11725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY00_RS11730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY00_RS11735	COG1737	Transcriptional regulator
GPY00_RS11740	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY00_RS11745	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY00_RS11780	COG0596	Alpha beta hydrolase
GPY00_RS11790	COG3064	Membrane
GPY00_RS11825	COG1943	Transposase
GPY00_RS11910	COG4789	Type iii secretion
GPY00_RS11915	COG4792	protein secretion
GPY00_RS11945	COG3710	Transcriptional regulator
GPY00_RS11955	COG4790	Type iii secretion
GPY00_RS12035	COG0582	viral genome integration into host DNA
GPY00_RS12050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY00_RS12060	COG3008	intermembrane lipid transfer
GPY00_RS12060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY00_RS12070	COG0668	transmembrane transport
GPY00_RS12090	COG1309	transcriptional regulator
GPY00_RS12095	COG1012	belongs to the aldehyde dehydrogenase family
GPY00_RS12120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY00_RS12125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY00_RS12130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY00_RS12135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY00_RS12145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY00_RS12155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY00_RS12160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY00_RS12165	COG0297	glycogen (starch) synthase activity
GPY00_RS12185	COG3070	regulator of competence-specific genes
GPY00_RS12190	COG1609	Transcriptional regulator
GPY00_RS12200	COG0745	RESPONSE REGULATOR receiver
GPY00_RS12205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY00_RS12210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY00_RS12215	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY00_RS12220	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY00_RS12225	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY00_RS12230	COG1979	alcohol dehydrogenase
GPY00_RS12235	COG2207	Transcriptional regulator
GPY00_RS12255	COG1032	radical SAM domain protein
GPY00_RS12260	COG5001	Diguanylate cyclase
GPY00_RS12265	COG0612	Peptidase, M16
GPY00_RS12280	COG0583	DNA-binding transcription factor activity
GPY00_RS12285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY00_RS12295	COG2350	Protein conserved in bacteria
GPY00_RS12300	COG1607	acyl-coa hydrolase
GPY00_RS12305	COG2917	probably involved in intracellular septation
GPY00_RS12315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY00_RS12320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY00_RS12330	COG2116	formate transmembrane transporter activity
GPY00_RS12335	COG4459	periplasmic nitrate reductase
GPY00_RS12340	COG3005	denitrification pathway
GPY00_RS12345	COG0243	molybdopterin cofactor binding
GPY00_RS12360	COG1227	inorganic diphosphatase activity
GPY00_RS12375	COG4172	Belongs to the ABC transporter superfamily
GPY00_RS12385	COG4171	peptide transport system, permease
GPY00_RS12390	COG4168	peptide transport system, permease
GPY00_RS12400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY00_RS12405	COG1842	Phage shock protein A
GPY00_RS12420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY00_RS12435	COG2818	Glycosylase
GPY00_RS12440	COG0626	cystathionine gamma-synthase activity
GPY00_RS12445	COG0626	cystathionine gamma-synthase activity
GPY00_RS12455	COG0733	neurotransmitter:sodium symporter activity
GPY00_RS12460	COG0564	pseudouridine synthase activity
GPY00_RS12465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY00_RS12470	COG4136	ATPase activity
GPY00_RS12475	COG4135	transport system, permease component
GPY00_RS12480	COG4134	Bacterial extracellular solute-binding protein
GPY00_RS12490	COG3313	Fe-S protein
GPY00_RS12500	COG0842	Transport permease protein
GPY00_RS12505	COG1131	(ABC) transporter
GPY00_RS12510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY00_RS12515	COG0814	amino acid
GPY00_RS12525	COG2239	Acts as a magnesium transporter
GPY00_RS12545	COG4934	collagen metabolic process
GPY00_RS12585	COG2203	Gaf domain
GPY00_RS12585	COG4251	negative regulation of phosphorylation
GPY00_RS12585	COG5001	Diguanylate cyclase
GPY00_RS12585	COG3706	GGDEF domain
GPY00_RS12590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY00_RS12595	COG5002	protein histidine kinase activity
GPY00_RS12610	COG1061	Type III restriction enzyme res subunit
GPY00_RS12615	COG1187	pseudouridine synthase activity
GPY00_RS12620	COG2814	Major facilitator Superfamily
GPY00_RS12630	COG0702	epimerase
GPY00_RS12635	COG0534	Mate efflux family protein
GPY00_RS12640	COG4181	ATPase activity
GPY00_RS12655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY00_RS12665	COG1748	Saccharopine dehydrogenase
GPY00_RS12670	COG0019	diaminopimelate decarboxylase activity
GPY00_RS12680	COG1538	Outer membrane efflux protein
GPY00_RS12690	COG3385	transposase activity
GPY00_RS12705	COG0583	DNA-binding transcription factor activity
GPY00_RS12715	COG1451	nucleotide metabolic process
GPY00_RS12730	COG3063	Type IV pilus biogenesis stability protein PilW
GPY00_RS12735	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY00_RS12755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY00_RS12770	COG3290	protein histidine kinase activity
GPY00_RS12775	COG4565	transcriptional regulatory protein
GPY00_RS12785	COG0835	chemotaxis
GPY00_RS12785	COG0784	Response regulator, receiver
GPY00_RS12805	COG3706	GGDEF domain
GPY00_RS12805	COG0745	RESPONSE REGULATOR receiver
GPY00_RS12830	COG1085	galactose-1-phosphate uridylyltransferase
GPY00_RS12835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY00_RS12840	COG2017	converts alpha-aldose to the beta-anomer
GPY00_RS12845	COG3706	GGDEF domain
GPY00_RS12850	COG2200	EAL domain
GPY00_RS12850	COG2199	diguanylate cyclase activity
GPY00_RS12865	COG3527	Alpha-acetolactate decarboxylase
GPY00_RS12880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPY00_RS12930	COG1271	oxidase subunit
GPY00_RS12935	COG1294	oxidase, subunit
GPY00_RS12940	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY00_RS12940	COG1136	(ABC) transporter
GPY00_RS12945	COG0577	efflux transmembrane transporter activity
GPY00_RS12945	COG1136	(ABC) transporter
GPY00_RS12950	COG0577	efflux transmembrane transporter activity
GPY00_RS12950	COG1136	(ABC) transporter
GPY00_RS12970	COG0583	DNA-binding transcription factor activity
GPY00_RS12975	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY00_RS12980	COG2723	6-phospho-beta-galactosidase activity
GPY00_RS12985	COG1609	Transcriptional regulator
GPY00_RS12990	COG0251	oxidation-reduction process
GPY00_RS12995	COG2731	YhcH YjgK YiaL family protein
GPY00_RS13000	COG0584	glycerophosphoryl diester phosphodiesterase
GPY00_RS13005	COG1349	DNA-binding transcription factor activity
GPY00_RS13010	COG3842	ATPase activity
GPY00_RS13015	COG0395	ABC-type sugar transport system, permease component
GPY00_RS13020	COG1175	transmembrane transport
GPY00_RS13035	COG0811	peptide transport
GPY00_RS13040	COG0811	peptide transport
GPY00_RS13045	COG0848	biopolymer transport protein
GPY00_RS13050	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY00_RS13060	COG1793	dna ligase
GPY00_RS13070	COG0534	Mate efflux family protein
GPY00_RS13090	COG0791	NLP P60 protein
GPY00_RS13095	COG0840	transmembrane signaling receptor activity
GPY00_RS13110	COG1940	carbohydrate kinase activity
GPY00_RS13125	COG0746	molybdenum cofactor guanylyltransferase activity
GPY00_RS13130	COG3842	ATPase activity
GPY00_RS13135	COG4662	Binding-protein-dependent transport system inner membrane component
GPY00_RS13145	COG2204	response regulator
GPY00_RS13150	COG3852	Histidine kinase
GPY00_RS13155	COG0488	(ABC) transporter
GPY00_RS13160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY00_RS13190	COG3383	formate dehydrogenase (NAD+) activity
GPY00_RS13190	COG0243	molybdopterin cofactor binding
GPY00_RS13195	COG0437	4 iron, 4 sulfur cluster binding
GPY00_RS13210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY00_RS13220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY00_RS13235	COG2996	Protein conserved in bacteria
GPY00_RS13240	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY00_RS13240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY00_RS13245	COG3008	intermembrane lipid transfer
GPY00_RS13250	COG2995	paraquat-inducible protein a
GPY00_RS13255	COG1132	(ABC) transporter
GPY00_RS13260	COG1956	GAF domain-containing protein
GPY00_RS13265	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY00_RS13280	COG0308	aminopeptidase N
GPY00_RS13295	COG0167	dihydroorotate dehydrogenase activity
GPY00_RS13305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY00_RS13305	COG0116	Belongs to the methyltransferase superfamily
GPY00_RS13330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY00_RS13335	COG1067	ATP-dependent peptidase activity
GPY00_RS13340	COG3120	sequence-specific DNA binding
GPY00_RS13435	COG4128	Pfam Zonular occludens toxin
GPY00_RS13500	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPY00_RS13500	COG3064	Membrane
GPY00_RS13500	COG1073	alpha beta
GPY00_RS13505	COG2994	toxin metabolic process
GPY00_RS13530	COG2205	protein histidine kinase activity
GPY00_RS13530	COG0784	Response regulator, receiver
GPY00_RS13545	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY00_RS13560	COG2010	Cytochrome c
GPY00_RS13570	COG2217	Heavy metal translocating P-type atpase
GPY00_RS13585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY00_RS13590	COG0589	response to stress
GPY00_RS13595	COG0037	tRNA processing
GPY00_RS13615	COG3842	ATPase activity
GPY00_RS13620	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY00_RS13625	COG1177	transmembrane transport
GPY00_RS13630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY00_RS13635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY00_RS13640	COG3385	transposase activity
GPY00_RS13655	COG1115	amino acid carrier protein
GPY00_RS13660	COG1280	lysine exporter protein (LysE YggA)
GPY00_RS13680	COG3501	Rhs element vgr protein
GPY00_RS13690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY00_RS13695	COG0840	transmembrane signaling receptor activity
GPY00_RS13700	COG2814	Major facilitator Superfamily
GPY00_RS13705	COG1566	PFAM secretion protein HlyD family protein
GPY00_RS13720	COG3385	transposase activity
GPY00_RS13725	COG0513	Belongs to the DEAD box helicase family
GPY00_RS13740	COG0840	transmembrane signaling receptor activity
GPY00_RS13745	COG0835	chemotaxis
GPY00_RS13750	COG2201	protein-glutamate methylesterase activity
GPY00_RS13760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY00_RS13770	COG0643	Histidine kinase
GPY00_RS13770	COG2198	Histidine kinase
GPY00_RS13780	COG0745	RESPONSE REGULATOR receiver
GPY00_RS13790	COG2076	Multidrug Resistance protein
GPY00_RS13795	COG0415	Belongs to the DNA photolyase family
GPY00_RS13800	COG0477	Major facilitator Superfamily
GPY00_RS13805	COG0583	DNA-binding transcription factor activity
GPY00_RS13815	COG0402	S-adenosylhomocysteine deaminase activity
GPY00_RS13820	COG0095	Lipoate-protein ligase
GPY00_RS13825	COG0443	Heat shock 70 kDa protein
GPY00_RS13835	COG1643	Atp-dependent helicase
GPY00_RS13870	COG0443	Heat shock 70 kDa protein
GPY00_RS13875	COG0443	Heat shock 70 kDa protein
GPY00_RS13880	COG3706	GGDEF domain
GPY00_RS13910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY00_RS13915	COG0602	queuosine metabolic process
GPY00_RS13920	COG0561	phosphatase activity
GPY00_RS13930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY00_RS13935	COG4597	amino acid ABC transporter
GPY00_RS13940	COG0765	amino acid transport
GPY00_RS13945	COG1126	abc transporter atp-binding protein
GPY00_RS13950	COG0670	Belongs to the BI1 family
GPY00_RS13955	COG2920	part of a sulfur-relay system
GPY00_RS13960	COG1254	Belongs to the acylphosphatase family
GPY00_RS13965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY00_RS13970	COG3706	GGDEF domain
GPY00_RS13980	COG2205	protein histidine kinase activity
GPY00_RS13980	COG4999	Histidine kinase
GPY00_RS13980	COG3437	response regulator, receiver
GPY00_RS13980	COG3850	Histidine kinase
GPY00_RS13985	COG3437	response regulator, receiver
GPY00_RS13990	COG0625	glutathione transferase activity
GPY00_RS14000	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY00_RS14010	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY00_RS14040	COG0372	Belongs to the citrate synthase family
GPY00_RS14045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY00_RS14050	COG2186	Transcriptional regulator
GPY00_RS14085	COG1129	ABC transporter
GPY00_RS14110	COG0745	RESPONSE REGULATOR receiver
GPY00_RS14115	COG5002	protein histidine kinase activity
GPY00_RS14120	COG3713	MltA-interacting MipA family protein
GPY00_RS14125	COG2990	Protein conserved in bacteria
GPY00_RS14155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY00_RS14205	COG2197	response regulator
GPY00_RS14215	COG1982	Orn Lys Arg decarboxylase major
GPY00_RS14220	COG0531	amino acid
GPY00_RS14225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY00_RS14230	COG1901	pseudouridine methyltransferase
GPY00_RS14240	COG4221	oxidoreductase activity
GPY00_RS14255	COG2910	NAD(P)H-binding
GPY00_RS14280	COG0673	inositol 2-dehydrogenase activity
GPY00_RS14285	COG3722	fumarate hydratase activity
GPY00_RS14290	COG0246	Mannitol dehydrogenase
GPY00_RS14295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY00_RS14295	COG2213	PTS system mannitol-specific
GPY00_RS14305	COG0739	heme binding
GPY00_RS14315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY00_RS14320	COG4597	amino acid ABC transporter
GPY00_RS14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY00_RS14335	COG1126	abc transporter atp-binding protein
GPY00_RS14340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY00_RS14350	COG0840	transmembrane signaling receptor activity
GPY00_RS14360	COG0840	transmembrane signaling receptor activity
GPY00_RS14375	COG4580	involved in the transport of maltose and maltodextrins
GPY00_RS14390	COG0363	glucosamine-6-phosphate deaminase activity
GPY00_RS14415	COG2259	Doxx family
GPY00_RS14420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY00_RS14425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY00_RS14435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY00_RS14440	COG3366	ferrous iron transmembrane transporter activity
GPY00_RS14445	COG0700	Nucleoside recognition
GPY00_RS14455	COG0697	spore germination
GPY00_RS14460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY00_RS14465	COG1764	response to oxidative stress
GPY00_RS14470	COG1846	Transcriptional regulator
GPY00_RS14490	COG2207	Transcriptional regulator
GPY00_RS14495	COG1280	lysine exporter protein (LysE YggA)
GPY00_RS14505	COG1902	pentaerythritol trinitrate reductase activity
GPY00_RS14530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY00_RS14540	COG0513	Belongs to the DEAD box helicase family
GPY00_RS14550	COG0840	transmembrane signaling receptor activity
GPY00_RS14560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY00_RS14570	COG1304	FMN binding
GPY00_RS14575	COG1620	l-lactate permease
GPY00_RS14580	COG0583	DNA-binding transcription factor activity
GPY00_RS14600	COG4172	Belongs to the ABC transporter superfamily
GPY00_RS14610	COG1067	ATP-dependent peptidase activity
GPY00_RS14625	COG2211	Major facilitator Superfamily
GPY00_RS14635	COG3123	guanosine phosphorylase activity
GPY00_RS14640	COG1741	Belongs to the pirin family
GPY00_RS14650	COG5001	Diguanylate cyclase
GPY00_RS14655	COG0583	DNA-binding transcription factor activity
GPY00_RS14690	COG3706	GGDEF domain
GPY00_RS14695	COG1846	Transcriptional regulator
GPY00_RS14700	COG0784	Response regulator, receiver
GPY00_RS14700	COG0835	chemotaxis
GPY00_RS14705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY00_RS14710	COG2197	response regulator
GPY00_RS14715	COG0393	Putative heavy-metal-binding
GPY00_RS14730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY00_RS14735	COG3842	ATPase activity
GPY00_RS14745	COG1175	transmembrane transport
GPY00_RS14750	COG3833	ABC-type maltose transport systems, permease component
GPY00_RS14765	COG1349	DNA-binding transcription factor activity
GPY00_RS14770	COG3706	GGDEF domain
GPY00_RS14780	COG2207	Transcriptional regulator
GPY00_RS14780	COG4753	response regulator
GPY00_RS14795	COG1278	Cold shock
GPY00_RS14800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY00_RS14805	COG2354	Protein conserved in bacteria
GPY00_RS14810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY00_RS14815	COG0418	dihydroorotase activity
GPY00_RS14820	COG3217	Mosc domain protein beta barrel domain protein
GPY00_RS14820	COG0633	Ferredoxin
GPY00_RS14820	COG3217	Mosc domain protein beta barrel domain protein
GPY00_RS14820	COG0633	Ferredoxin
GPY00_RS14855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY00_RS14860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY00_RS14870	COG0848	biopolymer transport protein
GPY00_RS14875	COG0811	peptide transport
GPY00_RS14880	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY00_RS14890	COG3721	Heme iron utilization protein
GPY00_RS14895	COG0748	coenzyme F420 binding
GPY00_RS14905	COG3835	regulator
GPY00_RS14910	COG2610	gluconate transmembrane transporter activity
GPY00_RS14915	COG1929	Belongs to the glycerate kinase type-1 family
GPY00_RS14940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY00_RS14945	COG0363	glucosamine-6-phosphate deaminase activity
GPY00_RS14950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY00_RS14955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY00_RS14960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY00_RS14980	COG0346	lactoylglutathione lyase activity
GPY00_RS14990	COG2873	o-acetylhomoserine
GPY00_RS14995	COG0156	8-amino-7-oxononanoate synthase activity
GPY00_RS15000	COG1063	alcohol dehydrogenase
GPY00_RS15005	COG0789	Transcriptional regulator
GPY00_RS15020	COG0583	DNA-binding transcription factor activity
GPY00_RS15025	COG3048	D-serine ammonia-lyase activity
GPY00_RS15035	COG1278	Cold shock
GPY00_RS15040	COG0557	exoribonuclease II activity
GPY00_RS15045	COG1686	Belongs to the peptidase S11 family
GPY00_RS15055	COG3047	cAMP biosynthetic process
GPY00_RS15065	COG3227	Zinc metalloprotease (Elastase)
GPY00_RS15075	COG2267	carboxylic ester hydrolase activity
GPY00_RS15080	COG2067	long-chain fatty acid transport protein
GPY00_RS15090	COG0366	Alpha amylase catalytic
GPY00_RS15095	COG4989	oxidoreductase activity
GPY00_RS15110	COG3706	GGDEF domain
GPY00_RS15115	COG0531	amino acid
GPY00_RS15120	COG1252	NADH dehydrogenase
GPY00_RS15150	COG1765	OsmC-like protein
GPY00_RS15155	COG1253	flavin adenine dinucleotide binding
GPY00_RS15160	COG2171	N-acyltransferase activity
GPY00_RS15175	COG0583	DNA-binding transcription factor activity
GPY00_RS15180	COG2264	protein methyltransferase activity
GPY00_RS15195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY00_RS15200	COG3186	Phenylalanine-4-hydroxylase
GPY00_RS15205	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY00_RS15210	COG0456	acetyltransferase
GPY00_RS15215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY00_RS15220	COG0662	Cupin 2, conserved barrel domain protein
GPY00_RS15225	COG0527	aspartate kinase activity
GPY00_RS15235	COG0459	protein refolding
GPY00_RS15240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY00_RS15245	COG2239	Acts as a magnesium transporter
GPY00_RS15260	COG1166	arginine decarboxylase activity
GPY00_RS15265	COG0010	Belongs to the arginase family
GPY00_RS15275	COG3227	Zinc metalloprotease (Elastase)
GPY00_RS15280	COG3397	chitin binding
GPY00_RS15285	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY00_RS15295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY00_RS15305	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY00_RS15310	COG0513	Belongs to the DEAD box helicase family
GPY00_RS15320	COG1368	sulfuric ester hydrolase activity
GPY00_RS15325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY00_RS15340	COG0546	phosphoglycolate phosphatase activity
GPY00_RS15355	COG0484	heat shock protein binding
GPY00_RS15370	COG1716	ATPase activity
GPY00_RS15370	COG5001	Diguanylate cyclase
GPY00_RS15375	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY00_RS15385	COG4181	ATPase activity
GPY00_RS15390	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY00_RS15405	COG1984	allophanate hydrolase subunit 2
GPY00_RS15415	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY00_RS15420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY00_RS15425	COG0840	transmembrane signaling receptor activity
GPY00_RS15430	COG0814	amino acid
GPY00_RS15440	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY00_RS15445	COG0513	Belongs to the DEAD box helicase family
GPY00_RS15450	COG1309	transcriptional regulator
GPY00_RS15460	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY00_RS15465	COG0494	nUDIX hydrolase
GPY00_RS15475	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY00_RS15485	COG1126	abc transporter atp-binding protein
GPY00_RS15490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY00_RS15495	COG4215	(ABC) transporter
GPY00_RS15500	COG4160	amino acid transport
GPY00_RS15505	COG0583	DNA-binding transcription factor activity
GPY00_RS15535	COG3118	belongs to the thioredoxin family
GPY00_RS15540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY00_RS15545	COG0247	lactate metabolic process
GPY00_RS15550	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY00_RS15555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY00_RS15560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY00_RS15590	COG3132	Protein of unknown function, DUF480
GPY00_RS15595	COG2827	Endonuclease containing a URI domain
GPY00_RS15605	COG1879	ABC-type sugar transport system periplasmic component
GPY00_RS15610	COG5002	protein histidine kinase activity
GPY00_RS15610	COG0784	Response regulator, receiver
GPY00_RS15655	COG1492	cobalamin metabolic process
GPY00_RS15660	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY00_RS15665	COG4149	molybdate abc transporter
GPY00_RS15670	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY00_RS15700	COG1289	transmembrane transporter activity
GPY00_RS15705	COG0210	DNA helicase
GPY00_RS15710	COG3385	transposase activity
GPY00_RS15725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY00_RS15730	COG1335	isochorismatase
GPY00_RS15735	COG1803	Methylglyoxal synthase
GPY00_RS15740	COG1879	ABC-type sugar transport system periplasmic component
GPY00_RS15750	COG0469	pyruvate kinase activity
GPY00_RS15755	COG2271	Major facilitator Superfamily
GPY00_RS15760	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY00_RS15765	COG4191	Histidine kinase
GPY00_RS15780	COG1979	alcohol dehydrogenase
GPY00_RS15790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY00_RS15795	COG3706	GGDEF domain
GPY00_RS15810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY00_RS15815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY00_RS15825	COG0183	Belongs to the thiolase family
GPY00_RS15835	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY00_RS15840	COG3842	ATPase activity
GPY00_RS15850	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY00_RS15855	COG2271	Major facilitator Superfamily
GPY00_RS15860	COG3851	Histidine kinase
GPY00_RS15865	COG2197	response regulator
GPY00_RS15870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY00_RS15890	COG0243	molybdopterin cofactor binding
GPY00_RS15900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY00_RS15905	COG3850	Histidine kinase
GPY00_RS15910	COG2197	response regulator
GPY00_RS15915	COG1609	Transcriptional regulator
GPY00_RS15935	COG1760	l-serine dehydratase
GPY00_RS15940	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY00_RS15945	COG0840	transmembrane signaling receptor activity
GPY00_RS15950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY00_RS15955	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY00_RS15960	COG2885	chlorophyll binding
GPY00_RS15965	COG0840	transmembrane signaling receptor activity
GPY00_RS15970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY00_RS15975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY00_RS15980	COG1621	beta-fructofuranosidase activity
GPY00_RS15990	COG1263	PTS System
GPY00_RS15990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY00_RS16045	COG0640	Transcriptional regulator
GPY00_RS16070	COG0778	Nitroreductase
GPY00_RS16075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY00_RS16080	COG0583	DNA-binding transcription factor activity
GPY00_RS16105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY00_RS16135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY00_RS16140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY00_RS16150	COG2390	Transcriptional regulator
GPY00_RS16160	COG2897	thiosulfate sulfurtransferase activity
GPY00_RS16170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY00_RS16180	COG0302	gtp cyclohydrolase
GPY00_RS16185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY00_RS16185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY00_RS16190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY00_RS16195	COG1970	mechanosensitive ion channel activity
GPY00_RS16200	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY00_RS16210	COG1011	Hydrolase
GPY00_RS16215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY00_RS16220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY00_RS16235	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY00_RS16240	COG3842	ATPase activity
GPY00_RS16285	COG4166	transmembrane transport
GPY00_RS16290	COG4174	ABC transporter (Permease)
GPY00_RS16295	COG4239	(ABC) transporter, permease
GPY00_RS16300	COG4172	Belongs to the ABC transporter superfamily
GPY00_RS16305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY00_RS16320	COG0625	glutathione transferase activity
GPY00_RS16340	COG2050	protein possibly involved in aromatic compounds catabolism
GPY00_RS16355	COG1629	transport
GPY00_RS16355	COG4771	TonB-dependent receptor
GPY00_RS16360	COG0583	DNA-binding transcription factor activity
GPY00_RS16365	COG1042	CoA-binding domain protein
GPY00_RS16365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY00_RS16365	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY00_RS16375	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY00_RS16385	COG0023	Translation Initiation Factor
GPY00_RS16390	COG4128	Pfam Zonular occludens toxin
GPY00_RS16435	COG4128	Pfam Zonular occludens toxin
GPY00_RS16485	COG0745	RESPONSE REGULATOR receiver
GPY00_RS16495	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY00_RS16500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY00_RS16515	COG3706	GGDEF domain
GPY00_RS16570	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY00_RS16590	COG0737	Belongs to the 5'-nucleotidase family
GPY00_RS16595	COG3593	DNA synthesis involved in DNA repair
GPY00_RS16605	COG0583	DNA-binding transcription factor activity
GPY00_RS16610	COG2116	formate transmembrane transporter activity
GPY00_RS16620	COG3038	cytochrome b561
GPY00_RS16630	COG2200	EAL domain
GPY00_RS16640	COG0586	Pfam SNARE associated Golgi protein
GPY00_RS16645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY00_RS16650	COG0745	RESPONSE REGULATOR receiver
GPY00_RS16655	COG2205	protein histidine kinase activity
GPY00_RS16660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY00_RS16660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPY00_RS16660	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY00_RS16660	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY00_RS16665	COG3158	transport of potassium into the cell
GPY00_RS16675	COG0523	cobalamin synthesis protein
GPY00_RS16690	COG0156	8-amino-7-oxononanoate synthase activity
GPY00_RS16695	COG0784	Response regulator, receiver
GPY00_RS16695	COG2205	protein histidine kinase activity
GPY00_RS16700	COG0419	ATPase involved in DNA repair
GPY00_RS16705	COG0420	3'-5' exonuclease activity
GPY00_RS16710	COG1609	Transcriptional regulator
GPY00_RS16720	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY00_RS16725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY00_RS16725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY00_RS16725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY00_RS16730	COG0189	ligase activity
GPY00_RS16730	COG4067	protein conserved in archaea
GPY00_RS16740	COG0602	queuosine metabolic process
GPY00_RS16745	COG1328	CTP reductase activity
GPY00_RS16780	COG0456	acetyltransferase
GPY00_RS16840	COG0625	glutathione transferase activity
GPY00_RS16870	COG4977	sequence-specific DNA binding
GPY00_RS16880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY00_RS16935	COG0456	acetyltransferase
GPY00_RS16990	COG0384	phenazine biosynthesis protein PhzF
GPY00_RS17010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY00_RS17130	COG0454	-acetyltransferase
GPY00_RS17165	COG0384	phenazine biosynthesis protein PhzF
GPY00_RS17220	COG0110	maltose O-acetyltransferase activity
GPY00_RS17250	COG0346	lactoylglutathione lyase activity
GPY00_RS17300	COG3040	lipid binding
GPY00_RS17330	COG4977	sequence-specific DNA binding
GPY00_RS17390	COG0625	glutathione transferase activity
GPY00_RS17405	COG0384	phenazine biosynthesis protein PhzF
GPY00_RS17410	COG1418	mRNA catabolic process
GPY00_RS17425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPY00_RS17430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY00_RS17440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY00_RS17445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY00_RS17455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY00_RS17460	COG0509	glycine decarboxylation via glycine cleavage system
GPY00_RS17465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY00_RS17465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY00_RS17470	COG3385	transposase activity
GPY00_RS17475	COG3338	carbonate dehydratase activity
GPY00_RS17490	COG1686	Belongs to the peptidase S11 family
GPY00_RS17505	COG2814	Major facilitator Superfamily
GPY00_RS17535	COG0745	RESPONSE REGULATOR receiver
GPY00_RS17555	COG0366	Alpha amylase catalytic
GPY00_RS17590	COG0561	phosphatase activity
GPY00_RS17595	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPY00_RS17600	COG3623	hexulose-6-phosphate isomerase
GPY00_RS17610	COG0745	RESPONSE REGULATOR receiver
GPY00_RS17635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY00_RS17655	COG4604	ABC transporter, ATP-binding protein
GPY00_RS17660	COG4605	iron ion homeostasis
GPY00_RS17665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY00_RS17685	COG3291	Pkd domain containing protein
GPY00_RS17685	COG4412	M6 family metalloprotease domain protein
GPY00_RS17690	COG5380	lipid catabolic process
GPY00_RS17695	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY00_RS17700	COG0840	transmembrane signaling receptor activity
GPY00_RS17720	COG3240	lipase activity
GPY00_RS17725	COG3706	GGDEF domain
GPY00_RS17735	COG2814	Major facilitator Superfamily
GPY00_RS17740	COG1757	Na H antiporter
GPY00_RS17750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY00_RS17750	COG4191	Histidine kinase
GPY00_RS17755	COG3437	response regulator, receiver
GPY00_RS17755	COG0784	Response regulator, receiver
GPY00_RS17760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY00_RS17765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY00_RS17770	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY00_RS17775	COG0513	Belongs to the DEAD box helicase family
GPY00_RS17905	COG4695	Portal protein
GPY00_RS17965	COG0488	(ABC) transporter
GPY00_RS18005	COG3941	tape measure
GPY00_RS18075	COG4974	Belongs to the 'phage' integrase family
GPY00_RS18085	COG0516	GMP reductase activity
GPY00_RS18095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY00_RS18105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY00_RS18110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY00_RS18110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY00_RS18135	COG3036	rescue of stalled ribosome
GPY00_RS18140	COG1278	Cold shock
GPY00_RS18145	COG1017	nitric oxide dioxygenase activity
GPY00_RS18145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY00_RS18150	COG3604	Transcriptional regulator
GPY00_RS18160	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY00_RS18165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY00_RS18180	COG0840	transmembrane signaling receptor activity
GPY00_RS18185	COG0714	Associated with various cellular activities
GPY00_RS18220	COG1278	Cold shock
GPY00_RS18225	COG5001	Diguanylate cyclase
GPY00_RS18225	COG5002	protein histidine kinase activity
GPY00_RS18235	COG3530	Putative quorum-sensing-regulated virulence factor
GPY00_RS18245	COG3033	Beta-eliminating lyase
GPY00_RS18260	COG0589	response to stress
GPY00_RS18270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPY00_RS18270	COG2111	Na H antiporter
GPY00_RS18290	COG2212	antiporter activity
GPY00_RS18295	COG1320	monovalent cation:proton antiporter activity
GPY00_RS18300	COG1017	nitric oxide dioxygenase activity
GPY00_RS18300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY00_RS18305	COG0242	peptide deformylase activity
GPY00_RS18315	COG0579	oxidoreductase
GPY00_RS18350	COG2271	Major facilitator Superfamily
GPY00_RS18355	COG0584	glycerophosphoryl diester phosphodiesterase
GPY00_RS18365	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY00_RS18375	COG1609	Transcriptional regulator
GPY00_RS18380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY00_RS18385	COG1879	ABC-type sugar transport system periplasmic component
GPY00_RS18390	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY00_RS18395	COG1129	ABC transporter
GPY00_RS18400	COG1869	D-ribose catabolic process
GPY00_RS18420	COG3501	Rhs element vgr protein
GPY00_RS18465	COG3385	transposase activity
GPY00_RS18520	COG0564	pseudouridine synthase activity
GPY00_RS18530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY00_RS18535	COG2200	EAL domain
GPY00_RS18535	COG2771	luxR family
GPY00_RS18545	COG0673	inositol 2-dehydrogenase activity
GPY00_RS18550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY00_RS18580	COG1342	Belongs to the UPF0251 family
GPY00_RS18590	COG1301	dicarboxylic acid transport
GPY00_RS18615	COG2814	Major facilitator Superfamily
GPY00_RS18620	COG0583	DNA-binding transcription factor activity
GPY00_RS18625	COG3300	MHYT domain
GPY00_RS18625	COG5001	Diguanylate cyclase
GPY00_RS18630	COG0739	heme binding
GPY00_RS18640	COG0659	secondary active sulfate transmembrane transporter activity
GPY00_RS18660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY00_RS18665	COG0581	inorganic phosphate transmembrane transporter activity
GPY00_RS18670	COG0573	inorganic phosphate transmembrane transporter activity
GPY00_RS18675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY00_RS18705	COG1770	oligopeptidase
GPY00_RS18710	COG0513	Belongs to the DEAD box helicase family
GPY00_RS18720	COG1376	ErfK ybiS ycfS ynhG family protein
GPY00_RS18720	COG1388	LysM domain
GPY00_RS18725	COG0415	Belongs to the DNA photolyase family
GPY00_RS18735	COG3272	Protein of unknown function (DUF1722)
GPY00_RS18740	COG0813	purine-nucleoside phosphorylase activity
GPY00_RS18755	COG3706	GGDEF domain
GPY00_RS18775	COG0786	glutamate:sodium symporter activity
GPY00_RS18790	COG1999	signal sequence binding
GPY00_RS18800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY00_RS18805	COG0671	phosphoesterase, PA-phosphatase related
GPY00_RS18850	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY00_RS18855	COG3385	transposase activity
GPY00_RS18860	COG0471	metal ion transport
GPY00_RS18900	COG3501	Rhs element vgr protein
GPY00_RS18910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY00_RS18915	COG1640	4-alpha-glucanotransferase
GPY00_RS18920	COG0058	SHG alpha-glucan phosphorylase activity
GPY00_RS18925	COG2909	trisaccharide binding
GPY00_RS18945	COG2084	Dehydrogenase
GPY00_RS18950	COG0217	transcriptional regulatory protein
GPY00_RS18985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY00_RS18990	COG1444	tRNA N-acetyltransferase activity
GPY00_RS19020	COG0745	RESPONSE REGULATOR receiver
GPY00_RS19025	COG0642	Histidine kinase
GPY00_RS19030	COG2194	sulfuric ester hydrolase activity
GPY00_RS19040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY00_RS19045	COG0601	transmembrane transport
GPY00_RS19050	COG0747	negative chemotaxis
GPY00_RS19065	COG0643	Histidine kinase
GPY00_RS19065	COG2198	Histidine kinase
GPY00_RS19070	COG0835	chemotaxis
GPY00_RS19075	COG0835	chemotaxis
GPY00_RS19080	COG0840	transmembrane signaling receptor activity
GPY00_RS19085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY00_RS19090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY00_RS19110	COG0745	RESPONSE REGULATOR receiver
GPY00_RS19140	COG0259	pyridoxamine-phosphate oxidase activity