locus-tag	class	description
GPW70_RS00005	COG0456	acetyltransferase
GPW70_RS00055	COG3385	transposase activity
GPW70_RS00065	COG0625	glutathione transferase activity
GPW70_RS00095	COG0456	acetyltransferase
GPW70_RS00095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPW70_RS00145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW70_RS00195	COG0456	acetyltransferase
GPW70_RS00230	COG0384	phenazine biosynthesis protein PhzF
GPW70_RS00245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW70_RS00485	COG0456	acetyltransferase
GPW70_RS00485	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPW70_RS00495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW70_RS00495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW70_RS00580	COG0346	lactoylglutathione lyase activity
GPW70_RS00630	COG0384	phenazine biosynthesis protein PhzF
GPW70_RS00670	COG0456	acetyltransferase
GPW70_RS00805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPW70_RS00810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPW70_RS00820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPW70_RS00825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPW70_RS00835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW70_RS00840	COG0509	glycine decarboxylation via glycine cleavage system
GPW70_RS00845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW70_RS00845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW70_RS00870	COG1686	Belongs to the peptidase S11 family
GPW70_RS00885	COG2814	Major facilitator Superfamily
GPW70_RS00925	COG5000	phosphorelay sensor kinase activity
GPW70_RS00925	COG5002	protein histidine kinase activity
GPW70_RS00930	COG0745	RESPONSE REGULATOR receiver
GPW70_RS00950	COG0366	Alpha amylase catalytic
GPW70_RS00985	COG0561	phosphatase activity
GPW70_RS00990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPW70_RS00995	COG3623	hexulose-6-phosphate isomerase
GPW70_RS01005	COG0745	RESPONSE REGULATOR receiver
GPW70_RS01020	COG0583	DNA-binding transcription factor activity
GPW70_RS01050	COG1401	restriction endodeoxyribonuclease activity
GPW70_RS01060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPW70_RS01065	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GPW70_RS01075	COG1943	Transposase
GPW70_RS01080	COG3385	transposase activity
GPW70_RS01085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW70_RS01105	COG4604	ABC transporter, ATP-binding protein
GPW70_RS01110	COG4605	iron ion homeostasis
GPW70_RS01115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW70_RS01160	COG0784	Response regulator, receiver
GPW70_RS01160	COG5002	protein histidine kinase activity
GPW70_RS01165	COG1879	ABC-type sugar transport system periplasmic component
GPW70_RS01175	COG2827	Endonuclease containing a URI domain
GPW70_RS01205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPW70_RS01210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPW70_RS01220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW70_RS01230	COG0247	lactate metabolic process
GPW70_RS01235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW70_RS01240	COG3118	belongs to the thioredoxin family
GPW70_RS01270	COG0583	DNA-binding transcription factor activity
GPW70_RS01275	COG4160	amino acid transport
GPW70_RS01280	COG4215	(ABC) transporter
GPW70_RS01285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW70_RS01290	COG1126	abc transporter atp-binding protein
GPW70_RS01300	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPW70_RS01310	COG0494	nUDIX hydrolase
GPW70_RS01315	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPW70_RS01325	COG1309	transcriptional regulator
GPW70_RS01330	COG0513	Belongs to the DEAD box helicase family
GPW70_RS01335	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPW70_RS01345	COG0814	amino acid
GPW70_RS01350	COG0840	transmembrane signaling receptor activity
GPW70_RS01355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPW70_RS01360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPW70_RS01370	COG1984	allophanate hydrolase subunit 2
GPW70_RS01385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPW70_RS01390	COG4181	ATPase activity
GPW70_RS01400	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW70_RS01405	COG1716	ATPase activity
GPW70_RS01405	COG5001	Diguanylate cyclase
GPW70_RS01420	COG0484	heat shock protein binding
GPW70_RS01435	COG0546	phosphoglycolate phosphatase activity
GPW70_RS01450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW70_RS01455	COG1368	sulfuric ester hydrolase activity
GPW70_RS01465	COG0513	Belongs to the DEAD box helicase family
GPW70_RS01470	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPW70_RS01480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW70_RS01490	COG3046	protein related to deoxyribodipyrimidine photolyase
GPW70_RS01495	COG3397	chitin binding
GPW70_RS01500	COG3227	Zinc metalloprotease (Elastase)
GPW70_RS01510	COG0010	Belongs to the arginase family
GPW70_RS01515	COG1166	arginine decarboxylase activity
GPW70_RS01525	COG2239	Acts as a magnesium transporter
GPW70_RS01530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW70_RS01535	COG0459	protein refolding
GPW70_RS01545	COG0527	aspartate kinase activity
GPW70_RS01550	COG0662	Cupin 2, conserved barrel domain protein
GPW70_RS01555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPW70_RS01560	COG0456	acetyltransferase
GPW70_RS01565	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPW70_RS01570	COG3186	Phenylalanine-4-hydroxylase
GPW70_RS01575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW70_RS01590	COG2264	protein methyltransferase activity
GPW70_RS01595	COG0583	DNA-binding transcription factor activity
GPW70_RS01610	COG2171	N-acyltransferase activity
GPW70_RS01615	COG1253	flavin adenine dinucleotide binding
GPW70_RS01620	COG1765	OsmC-like protein
GPW70_RS01650	COG1252	NADH dehydrogenase
GPW70_RS01660	COG3706	GGDEF domain
GPW70_RS01675	COG4989	oxidoreductase activity
GPW70_RS01680	COG0366	Alpha amylase catalytic
GPW70_RS01690	COG2067	long-chain fatty acid transport protein
GPW70_RS01695	COG2267	carboxylic ester hydrolase activity
GPW70_RS01705	COG3227	Zinc metalloprotease (Elastase)
GPW70_RS01715	COG3047	cAMP biosynthetic process
GPW70_RS01725	COG1686	Belongs to the peptidase S11 family
GPW70_RS01730	COG0557	exoribonuclease II activity
GPW70_RS01735	COG1278	Cold shock
GPW70_RS01745	COG3048	D-serine ammonia-lyase activity
GPW70_RS01750	COG0583	DNA-binding transcription factor activity
GPW70_RS01765	COG0789	Transcriptional regulator
GPW70_RS01770	COG1063	alcohol dehydrogenase
GPW70_RS01775	COG0156	8-amino-7-oxononanoate synthase activity
GPW70_RS01780	COG2873	o-acetylhomoserine
GPW70_RS01790	COG0346	lactoylglutathione lyase activity
GPW70_RS01815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW70_RS01820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPW70_RS01825	COG0363	glucosamine-6-phosphate deaminase activity
GPW70_RS01830	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPW70_RS01855	COG1929	Belongs to the glycerate kinase type-1 family
GPW70_RS01865	COG0748	coenzyme F420 binding
GPW70_RS01870	COG3721	Heme iron utilization protein
GPW70_RS01880	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW70_RS01885	COG0811	peptide transport
GPW70_RS01890	COG0848	biopolymer transport protein
GPW70_RS01895	COG4558	Periplasmic binding protein
GPW70_RS01900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW70_RS01905	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPW70_RS01940	COG3217	Mosc domain protein beta barrel domain protein
GPW70_RS01940	COG0633	Ferredoxin
GPW70_RS01940	COG3217	Mosc domain protein beta barrel domain protein
GPW70_RS01940	COG0633	Ferredoxin
GPW70_RS01945	COG0418	dihydroorotase activity
GPW70_RS01950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW70_RS01955	COG2354	Protein conserved in bacteria
GPW70_RS01960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW70_RS01965	COG1278	Cold shock
GPW70_RS01990	COG3706	GGDEF domain
GPW70_RS01995	COG1349	DNA-binding transcription factor activity
GPW70_RS02010	COG3833	ABC-type maltose transport systems, permease component
GPW70_RS02015	COG1175	transmembrane transport
GPW70_RS02025	COG3842	ATPase activity
GPW70_RS02030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW70_RS02045	COG0393	Putative heavy-metal-binding
GPW70_RS02050	COG2197	response regulator
GPW70_RS02055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW70_RS02060	COG0784	Response regulator, receiver
GPW70_RS02060	COG0835	chemotaxis
GPW70_RS02065	COG1846	Transcriptional regulator
GPW70_RS02070	COG3706	GGDEF domain
GPW70_RS02105	COG0583	DNA-binding transcription factor activity
GPW70_RS02110	COG5001	Diguanylate cyclase
GPW70_RS02120	COG1741	Belongs to the pirin family
GPW70_RS02125	COG3123	guanosine phosphorylase activity
GPW70_RS02135	COG2211	Major facilitator Superfamily
GPW70_RS02150	COG1067	ATP-dependent peptidase activity
GPW70_RS02160	COG4172	Belongs to the ABC transporter superfamily
GPW70_RS02180	COG0583	DNA-binding transcription factor activity
GPW70_RS02185	COG1620	l-lactate permease
GPW70_RS02190	COG1304	FMN binding
GPW70_RS02200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPW70_RS02210	COG0840	transmembrane signaling receptor activity
GPW70_RS02220	COG0513	Belongs to the DEAD box helicase family
GPW70_RS02230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPW70_RS02245	COG1132	(ABC) transporter
GPW70_RS02255	COG1902	pentaerythritol trinitrate reductase activity
GPW70_RS02265	COG1280	lysine exporter protein (LysE YggA)
GPW70_RS02270	COG2207	Transcriptional regulator
GPW70_RS02290	COG1846	Transcriptional regulator
GPW70_RS02295	COG1764	response to oxidative stress
GPW70_RS02300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW70_RS02305	COG0697	spore germination
GPW70_RS02315	COG0700	Nucleoside recognition
GPW70_RS02335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPW70_RS02345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPW70_RS02350	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPW70_RS02355	COG2259	Doxx family
GPW70_RS02380	COG0363	glucosamine-6-phosphate deaminase activity
GPW70_RS02395	COG4580	involved in the transport of maltose and maltodextrins
GPW70_RS02410	COG0840	transmembrane signaling receptor activity
GPW70_RS02420	COG0840	transmembrane signaling receptor activity
GPW70_RS02430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW70_RS02435	COG1126	abc transporter atp-binding protein
GPW70_RS02445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW70_RS02450	COG4597	amino acid ABC transporter
GPW70_RS02455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW70_RS02465	COG0739	heme binding
GPW70_RS02475	COG2213	PTS system mannitol-specific
GPW70_RS02475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW70_RS02480	COG0246	Mannitol dehydrogenase
GPW70_RS02485	COG3722	fumarate hydratase activity
GPW70_RS02490	COG0673	inositol 2-dehydrogenase activity
GPW70_RS02520	COG2910	NAD(P)H-binding
GPW70_RS02530	COG0840	transmembrane signaling receptor activity
GPW70_RS02535	COG4221	oxidoreductase activity
GPW70_RS02545	COG1901	pseudouridine methyltransferase
GPW70_RS02550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW70_RS02560	COG0531	amino acid
GPW70_RS02565	COG1982	Orn Lys Arg decarboxylase major
GPW70_RS02575	COG2197	response regulator
GPW70_RS02580	COG2409	Drug exporters of the RND superfamily
GPW70_RS02615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW70_RS02640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPW70_RS02650	COG0259	pyridoxamine-phosphate oxidase activity
GPW70_RS02685	COG0745	RESPONSE REGULATOR receiver
GPW70_RS02705	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPW70_RS02710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW70_RS02715	COG0840	transmembrane signaling receptor activity
GPW70_RS02720	COG0835	chemotaxis
GPW70_RS02725	COG0835	chemotaxis
GPW70_RS02730	COG0643	Histidine kinase
GPW70_RS02730	COG2198	Histidine kinase
GPW70_RS02750	COG0601	transmembrane transport
GPW70_RS02755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW70_RS02765	COG2194	sulfuric ester hydrolase activity
GPW70_RS02770	COG0642	Histidine kinase
GPW70_RS02775	COG0745	RESPONSE REGULATOR receiver
GPW70_RS02805	COG1444	tRNA N-acetyltransferase activity
GPW70_RS02810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW70_RS02845	COG0217	transcriptional regulatory protein
GPW70_RS02850	COG2084	Dehydrogenase
GPW70_RS02870	COG2909	trisaccharide binding
GPW70_RS02875	COG0058	SHG alpha-glucan phosphorylase activity
GPW70_RS02880	COG1640	4-alpha-glucanotransferase
GPW70_RS02885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPW70_RS02890	COG3385	transposase activity
GPW70_RS02900	COG3501	Rhs element vgr protein
GPW70_RS02930	COG3385	transposase activity
GPW70_RS02935	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW70_RS02980	COG0671	phosphoesterase, PA-phosphatase related
GPW70_RS02985	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPW70_RS02995	COG1999	signal sequence binding
GPW70_RS03010	COG0786	glutamate:sodium symporter activity
GPW70_RS03030	COG3706	GGDEF domain
GPW70_RS03045	COG0813	purine-nucleoside phosphorylase activity
GPW70_RS03050	COG3272	Protein of unknown function (DUF1722)
GPW70_RS03060	COG0415	Belongs to the DNA photolyase family
GPW70_RS03065	COG1376	ErfK ybiS ycfS ynhG family protein
GPW70_RS03065	COG1388	LysM domain
GPW70_RS03075	COG0513	Belongs to the DEAD box helicase family
GPW70_RS03080	COG1770	oligopeptidase
GPW70_RS03110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW70_RS03115	COG0573	inorganic phosphate transmembrane transporter activity
GPW70_RS03120	COG0581	inorganic phosphate transmembrane transporter activity
GPW70_RS03125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW70_RS03150	COG0659	secondary active sulfate transmembrane transporter activity
GPW70_RS03160	COG0739	heme binding
GPW70_RS03165	COG3300	MHYT domain
GPW70_RS03165	COG5001	Diguanylate cyclase
GPW70_RS03170	COG0583	DNA-binding transcription factor activity
GPW70_RS03175	COG2814	Major facilitator Superfamily
GPW70_RS03200	COG1301	dicarboxylic acid transport
GPW70_RS03210	COG1342	Belongs to the UPF0251 family
GPW70_RS03240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPW70_RS03245	COG0673	inositol 2-dehydrogenase activity
GPW70_RS03255	COG2200	EAL domain
GPW70_RS03255	COG2771	luxR family
GPW70_RS03260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW70_RS03270	COG0564	pseudouridine synthase activity
GPW70_RS03365	COG3501	Rhs element vgr protein
GPW70_RS03380	COG1869	D-ribose catabolic process
GPW70_RS03385	COG1129	ABC transporter
GPW70_RS03390	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPW70_RS03395	COG1879	ABC-type sugar transport system periplasmic component
GPW70_RS03400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW70_RS03405	COG1609	Transcriptional regulator
GPW70_RS03415	COG0813	purine-nucleoside phosphorylase activity
GPW70_RS03425	COG0584	glycerophosphoryl diester phosphodiesterase
GPW70_RS03430	COG2271	Major facilitator Superfamily
GPW70_RS03470	COG0579	oxidoreductase
GPW70_RS03480	COG3385	transposase activity
GPW70_RS03485	COG0242	peptide deformylase activity
GPW70_RS03490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW70_RS03490	COG1017	nitric oxide dioxygenase activity
GPW70_RS03495	COG1320	monovalent cation:proton antiporter activity
GPW70_RS03500	COG2212	antiporter activity
GPW70_RS03520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW70_RS03520	COG2111	Na H antiporter
GPW70_RS03535	COG0814	amino acid
GPW70_RS03540	COG3033	Beta-eliminating lyase
GPW70_RS03550	COG3530	Putative quorum-sensing-regulated virulence factor
GPW70_RS03560	COG5001	Diguanylate cyclase
GPW70_RS03560	COG5002	protein histidine kinase activity
GPW70_RS03565	COG1278	Cold shock
GPW70_RS03580	COG2304	oxidoreductase activity
GPW70_RS03600	COG0714	Associated with various cellular activities
GPW70_RS03605	COG0840	transmembrane signaling receptor activity
GPW70_RS03620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW70_RS03625	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW70_RS03635	COG3604	Transcriptional regulator
GPW70_RS03640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW70_RS03640	COG1017	nitric oxide dioxygenase activity
GPW70_RS03645	COG1278	Cold shock
GPW70_RS03650	COG3036	rescue of stalled ribosome
GPW70_RS03675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPW70_RS03675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPW70_RS03680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW70_RS03690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW70_RS03700	COG0516	GMP reductase activity
GPW70_RS03725	COG0513	Belongs to the DEAD box helicase family
GPW70_RS03730	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW70_RS03735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPW70_RS03740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPW70_RS03745	COG3437	response regulator, receiver
GPW70_RS03745	COG0784	Response regulator, receiver
GPW70_RS03750	COG4191	Histidine kinase
GPW70_RS03750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW70_RS03760	COG1757	Na H antiporter
GPW70_RS03765	COG2814	Major facilitator Superfamily
GPW70_RS03775	COG3706	GGDEF domain
GPW70_RS03780	COG3240	lipase activity
GPW70_RS03790	COG0840	transmembrane signaling receptor activity
GPW70_RS03795	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPW70_RS03800	COG5380	lipid catabolic process
GPW70_RS03805	COG4412	M6 family metalloprotease domain protein
GPW70_RS03805	COG3291	Pkd domain containing protein
GPW70_RS03825	COG1492	cobalamin metabolic process
GPW70_RS03830	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPW70_RS03835	COG4149	molybdate abc transporter
GPW70_RS03840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPW70_RS03870	COG1289	transmembrane transporter activity
GPW70_RS03875	COG0210	DNA helicase
GPW70_RS03880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPW70_RS03885	COG1335	isochorismatase
GPW70_RS03890	COG1803	Methylglyoxal synthase
GPW70_RS03895	COG1879	ABC-type sugar transport system periplasmic component
GPW70_RS03900	COG2205	protein histidine kinase activity
GPW70_RS03900	COG2198	Histidine kinase
GPW70_RS03900	COG0784	Response regulator, receiver
GPW70_RS03905	COG0469	pyruvate kinase activity
GPW70_RS03910	COG2271	Major facilitator Superfamily
GPW70_RS03915	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW70_RS03920	COG4191	Histidine kinase
GPW70_RS03935	COG1979	alcohol dehydrogenase
GPW70_RS03945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW70_RS03950	COG3706	GGDEF domain
GPW70_RS03965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW70_RS03970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW70_RS03980	COG0183	Belongs to the thiolase family
GPW70_RS03990	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPW70_RS03995	COG3842	ATPase activity
GPW70_RS04005	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW70_RS04010	COG2271	Major facilitator Superfamily
GPW70_RS04015	COG3851	Histidine kinase
GPW70_RS04020	COG2197	response regulator
GPW70_RS04025	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW70_RS04045	COG0243	molybdopterin cofactor binding
GPW70_RS04055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW70_RS04060	COG3850	Histidine kinase
GPW70_RS04065	COG2197	response regulator
GPW70_RS04070	COG1760	l-serine dehydratase
GPW70_RS04075	COG3069	C4-dicarboxylate transmembrane transporter activity
GPW70_RS04080	COG0840	transmembrane signaling receptor activity
GPW70_RS04085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW70_RS04090	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW70_RS04095	COG2885	chlorophyll binding
GPW70_RS04105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW70_RS04110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW70_RS04115	COG1621	beta-fructofuranosidase activity
GPW70_RS04125	COG1263	PTS System
GPW70_RS04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW70_RS04170	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW70_RS04180	COG0640	Transcriptional regulator
GPW70_RS04210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPW70_RS04215	COG0583	DNA-binding transcription factor activity
GPW70_RS04240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW70_RS04265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW70_RS04270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPW70_RS04280	COG2390	Transcriptional regulator
GPW70_RS04285	COG2897	thiosulfate sulfurtransferase activity
GPW70_RS04295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW70_RS04305	COG0302	gtp cyclohydrolase
GPW70_RS04310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW70_RS04310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW70_RS04315	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPW70_RS04320	COG1970	mechanosensitive ion channel activity
GPW70_RS04325	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPW70_RS04335	COG1011	Hydrolase
GPW70_RS04340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW70_RS04345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW70_RS04355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW70_RS04365	COG3842	ATPase activity
GPW70_RS04410	COG4166	transmembrane transport
GPW70_RS04415	COG4174	ABC transporter (Permease)
GPW70_RS04420	COG4239	(ABC) transporter, permease
GPW70_RS04425	COG4172	Belongs to the ABC transporter superfamily
GPW70_RS04430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPW70_RS04445	COG0625	glutathione transferase activity
GPW70_RS04465	COG2050	protein possibly involved in aromatic compounds catabolism
GPW70_RS04480	COG1629	transport
GPW70_RS04480	COG4771	TonB-dependent receptor
GPW70_RS04485	COG0583	DNA-binding transcription factor activity
GPW70_RS04490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW70_RS04490	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW70_RS04490	COG1042	CoA-binding domain protein
GPW70_RS04500	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPW70_RS04510	COG0023	Translation Initiation Factor
GPW70_RS04515	COG4128	Pfam Zonular occludens toxin
GPW70_RS04550	COG4128	Pfam Zonular occludens toxin
GPW70_RS04600	COG0745	RESPONSE REGULATOR receiver
GPW70_RS04610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPW70_RS04615	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPW70_RS04630	COG3706	GGDEF domain
GPW70_RS04685	COG2824	Alkylphosphonate utilization operon protein PhnA
GPW70_RS04705	COG0737	Belongs to the 5'-nucleotidase family
GPW70_RS04710	COG3593	DNA synthesis involved in DNA repair
GPW70_RS04720	COG0583	DNA-binding transcription factor activity
GPW70_RS04725	COG2116	formate transmembrane transporter activity
GPW70_RS04735	COG3038	cytochrome b561
GPW70_RS04745	COG2200	EAL domain
GPW70_RS04755	COG0586	Pfam SNARE associated Golgi protein
GPW70_RS04760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW70_RS04765	COG0745	RESPONSE REGULATOR receiver
GPW70_RS04770	COG2205	protein histidine kinase activity
GPW70_RS04775	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPW70_RS04775	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPW70_RS04775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPW70_RS04775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPW70_RS04780	COG3158	transport of potassium into the cell
GPW70_RS04790	COG0523	cobalamin synthesis protein
GPW70_RS04795	COG0038	chloride channel
GPW70_RS04805	COG0156	8-amino-7-oxononanoate synthase activity
GPW70_RS04810	COG2205	protein histidine kinase activity
GPW70_RS04810	COG0784	Response regulator, receiver
GPW70_RS04815	COG0419	ATPase involved in DNA repair
GPW70_RS04820	COG0420	3'-5' exonuclease activity
GPW70_RS04825	COG1609	Transcriptional regulator
GPW70_RS04830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW70_RS04830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW70_RS04835	COG1105	Belongs to the carbohydrate kinase PfkB family
GPW70_RS04840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW70_RS04840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW70_RS04840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPW70_RS04845	COG4067	protein conserved in archaea
GPW70_RS04845	COG0189	ligase activity
GPW70_RS04855	COG0602	queuosine metabolic process
GPW70_RS04860	COG1328	CTP reductase activity
GPW70_RS04910	COG0071	Belongs to the small heat shock protein (HSP20) family
GPW70_RS04915	COG3977	Valine--pyruvate aminotransferase
GPW70_RS04920	COG0751	glycine-tRNA ligase activity
GPW70_RS04925	COG0752	glycyl-tRNA synthetase alpha subunit
GPW70_RS04930	COG2119	membrane
GPW70_RS04940	COG0425	Belongs to the sulfur carrier protein TusA family
GPW70_RS04950	COG0604	alcohol dehydrogenase
GPW70_RS04960	COG0129	dihydroxy-acid dehydratase activity
GPW70_RS04965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW70_RS04980	COG0606	chelatase, subunit chli
GPW70_RS04985	COG0204	Acyl-transferase
GPW70_RS04995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW70_RS05000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPW70_RS05010	COG3084	Protein conserved in bacteria
GPW70_RS05015	COG3385	transposase activity
GPW70_RS05040	COG1272	protein, Hemolysin III
GPW70_RS05050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW70_RS05055	COG0569	domain protein
GPW70_RS05060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW70_RS05060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW70_RS05065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW70_RS05070	COG0242	peptide deformylase activity
GPW70_RS05075	COG1652	LysM domain
GPW70_RS05080	COG0758	DNA mediated transformation
GPW70_RS05085	COG2922	Belongs to the Smg family
GPW70_RS05090	COG0551	DNA topoisomerase type I activity
GPW70_RS05095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPW70_RS05100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPW70_RS05105	COG0009	L-threonylcarbamoyladenylate synthase
GPW70_RS05110	COG0408	coproporphyrinogen oxidase activity
GPW70_RS05115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPW70_RS05125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPW70_RS05165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPW70_RS05170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPW70_RS05180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW70_RS05185	COG2104	thiamine diphosphate biosynthetic process
GPW70_RS05190	COG2022	thiamine diphosphate biosynthetic process
GPW70_RS05195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW70_RS05200	COG0006	proline dipeptidase activity
GPW70_RS05220	COG1522	sequence-specific DNA binding
GPW70_RS05225	COG5002	protein histidine kinase activity
GPW70_RS05225	COG5001	Diguanylate cyclase
GPW70_RS05230	COG0742	ribosomal rna small subunit methyltransferase
GPW70_RS05240	COG0697	spore germination
GPW70_RS05245	COG0589	response to stress
GPW70_RS05255	COG1528	Iron-storage protein
GPW70_RS05265	COG2081	HI0933 family
GPW70_RS05275	COG1322	Protein conserved in bacteria
GPW70_RS05280	COG2226	methyltransferase
GPW70_RS05290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPW70_RS05295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW70_RS05300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW70_RS05305	COG0805	protein transport
GPW70_RS05310	COG1858	cytochrome C peroxidase
GPW70_RS05315	COG0534	Mate efflux family protein
GPW70_RS05325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPW70_RS05330	COG2937	Belongs to the GPAT DAPAT family
GPW70_RS05335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPW70_RS05340	COG3161	chorismate lyase activity
GPW70_RS05350	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW70_RS05365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW70_RS05370	COG0084	hydrolase, TatD family'
GPW70_RS05385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW70_RS05385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW70_RS05390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPW70_RS05405	COG3078	GTPase activator activity
GPW70_RS05415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW70_RS05420	COG3071	HemY protein
GPW70_RS05425	COG2959	enzyme of heme biosynthesis
GPW70_RS05430	COG1587	Uroporphyrinogen-III synthase
GPW70_RS05435	COG0181	hydroxymethylbilane synthase activity
GPW70_RS05445	COG3072	Adenylate cyclase
GPW70_RS05450	COG1965	Belongs to the frataxin family
GPW70_RS05460	COG0019	diaminopimelate decarboxylase activity
GPW70_RS05465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPW70_RS05475	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPW70_RS05480	COG1011	Hydrolase
GPW70_RS05485	COG2200	EAL domain
GPW70_RS05485	COG3287	FIST C domain
GPW70_RS05485	COG2199	diguanylate cyclase activity
GPW70_RS05500	COG0561	phosphatase activity
GPW70_RS05505	COG2267	carboxylic ester hydrolase activity
GPW70_RS05510	COG1280	lysine exporter protein (LysE YggA)
GPW70_RS05515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW70_RS05520	COG0783	Belongs to the Dps family
GPW70_RS05550	COG0742	ribosomal rna small subunit methyltransferase
GPW70_RS05555	COG0552	protein localization to endoplasmic reticulum
GPW70_RS05560	COG2884	Cell division ATP-binding protein ftsE
GPW70_RS05565	COG2177	Part of the ABC transporter FtsEX involved in
GPW70_RS05570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW70_RS05575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW70_RS05590	COG3385	transposase activity
GPW70_RS05615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPW70_RS05640	COG2003	Belongs to the UPF0758 family
GPW70_RS05655	COG3339	Conserved Protein
GPW70_RS05710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW70_RS05725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPW70_RS05800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPW70_RS05805	COG5001	Diguanylate cyclase
GPW70_RS05805	COG3300	MHYT domain
GPW70_RS05815	COG3852	Histidine kinase
GPW70_RS05825	COG0174	glutamine synthetase
GPW70_RS05840	COG1660	Displays ATPase and GTPase activities
GPW70_RS05850	COG1490	D-aminoacyl-tRNA deacylase activity
GPW70_RS05855	COG0456	acetyltransferase
GPW70_RS05865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPW70_RS05870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPW70_RS05875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPW70_RS05880	COG3031	protein transport across the cell outer membrane
GPW70_RS05890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW70_RS05895	COG1459	type II secretion system
GPW70_RS05900	COG2165	general secretion pathway protein
GPW70_RS05905	COG2165	general secretion pathway protein
GPW70_RS05910	COG2165	general secretion pathway protein
GPW70_RS05915	COG4795	General secretion pathway protein
GPW70_RS05920	COG3156	type II secretion system protein K
GPW70_RS05925	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW70_RS05930	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW70_RS05940	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPW70_RS05945	COG0494	nUDIX hydrolase
GPW70_RS05950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPW70_RS05950	COG0316	Belongs to the HesB IscA family
GPW70_RS05955	COG1040	competence protein
GPW70_RS05960	COG0596	Alpha beta hydrolase
GPW70_RS05970	COG2183	response to ionizing radiation
GPW70_RS05975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW70_RS05980	COG2199	diguanylate cyclase activity
GPW70_RS05985	COG0745	RESPONSE REGULATOR receiver
GPW70_RS05995	COG2233	PERMEase
GPW70_RS06000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPW70_RS06005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW70_RS06010	COG1758	RNA polymerase activity
GPW70_RS06015	COG0194	GDP metabolic process
GPW70_RS06020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPW70_RS06025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW70_RS06035	COG3263	regulation of cellular component size
GPW70_RS06045	COG4232	protein-disulfide reductase activity
GPW70_RS06060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW70_RS06065	COG1027	Aspartate ammonia-lyase
GPW70_RS06070	COG3706	GGDEF domain
GPW70_RS06075	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPW70_RS06080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPW70_RS06090	COG2205	protein histidine kinase activity
GPW70_RS06095	COG0745	RESPONSE REGULATOR receiver
GPW70_RS06105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPW70_RS06110	COG0205	6-phosphofructokinase activity
GPW70_RS06115	COG1494	fructose-1,6-bisphosphatase
GPW70_RS06120	COG3074	FtsZ-dependent cytokinesis
GPW70_RS06125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPW70_RS06130	COG0527	aspartate kinase activity
GPW70_RS06130	COG0460	homoserine dehydrogenase
GPW70_RS06135	COG0626	cystathionine gamma-synthase activity
GPW70_RS06140	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPW70_RS06145	COG0281	malic enzyme
GPW70_RS06150	COG0254	rRNA binding
GPW70_RS06155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPW70_RS06160	COG1609	Transcriptional regulator
GPW70_RS06165	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW70_RS06170	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPW70_RS06175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPW70_RS06180	COG1575	Belongs to the MenA family. Type 1 subfamily
GPW70_RS06185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW70_RS06195	COG0149	triose-phosphate isomerase activity
GPW70_RS06220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW70_RS06225	COG0459	protein refolding
GPW70_RS06235	COG1509	lysine 2,3-aminomutase activity
GPW70_RS06240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW70_RS06245	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW70_RS06250	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW70_RS06255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPW70_RS06260	COG1053	succinate dehydrogenase
GPW70_RS06265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPW70_RS06270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW70_RS06275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPW70_RS06280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPW70_RS06285	COG1045	serine acetyltransferase
GPW70_RS06295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPW70_RS06300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW70_RS06305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPW70_RS06310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW70_RS06315	COG0137	argininosuccinate synthase activity
GPW70_RS06320	COG0165	Argininosuccinate lyase
GPW70_RS06330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW70_RS06335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW70_RS06335	COG0678	peroxiredoxin activity
GPW70_RS06345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPW70_RS06375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPW70_RS06380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPW70_RS06390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPW70_RS06395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPW70_RS06400	COG0546	phosphoglycolate phosphatase activity
GPW70_RS06405	COG0180	Tryptophanyl-tRNA synthetase
GPW70_RS06420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW70_RS06430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPW70_RS06450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW70_RS06455	COG3954	Phosphoribulokinase
GPW70_RS06465	COG0429	hydrolase of the alpha beta-hydrolase fold
GPW70_RS06475	COG0488	(ABC) transporter
GPW70_RS06480	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPW70_RS06495	COG1047	Peptidyl-prolyl cis-trans
GPW70_RS06505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPW70_RS06510	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPW70_RS06515	COG3083	sulfuric ester hydrolase activity
GPW70_RS06520	COG0557	exoribonuclease II activity
GPW70_RS06525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW70_RS06530	COG0051	transcription antitermination factor activity, RNA binding
GPW70_RS06535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPW70_RS06540	COG0088	Forms part of the polypeptide exit tunnel
GPW70_RS06545	COG0089	rRNA binding
GPW70_RS06550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPW70_RS06555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPW70_RS06560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPW70_RS06565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPW70_RS06570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPW70_RS06575	COG0255	Belongs to the universal ribosomal protein uL29 family
GPW70_RS06580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPW70_RS06585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPW70_RS06590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPW70_RS06595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPW70_RS06600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPW70_RS06605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPW70_RS06610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPW70_RS06615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPW70_RS06620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPW70_RS06625	COG1841	ribosomal large subunit assembly
GPW70_RS06630	COG0200	Binds to the 23S rRNA
GPW70_RS06635	COG0201	protein transport
GPW70_RS06645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPW70_RS06650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPW70_RS06655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPW70_RS06660	COG0202	RNA polymerase activity
GPW70_RS06665	COG0203	ribosomal protein L17
GPW70_RS06675	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW70_RS06680	COG3266	domain, Protein
GPW70_RS06680	COG3061	Opacity-associated protein A
GPW70_RS06685	COG0697	spore germination
GPW70_RS06690	COG2153	protein acetylation
GPW70_RS06695	COG0513	Belongs to the DEAD box helicase family
GPW70_RS06705	COG0737	Belongs to the 5'-nucleotidase family
GPW70_RS06710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPW70_RS06710	COG1648	precorrin-2 dehydrogenase activity
GPW70_RS06715	COG0175	sulfate reduction
GPW70_RS06720	COG2895	sulfate adenylyltransferase (ATP) activity
GPW70_RS06725	COG0529	Catalyzes the synthesis of activated sulfate
GPW70_RS06745	COG1136	(ABC) transporter
GPW70_RS06760	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPW70_RS06765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW70_RS06770	COG0729	surface antigen
GPW70_RS06780	COG2105	PFAM AIG2 family protein
GPW70_RS06785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPW70_RS06790	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPW70_RS06795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW70_RS06800	COG0163	prenyltransferase activity
GPW70_RS06805	COG4143	(ABC) transporter
GPW70_RS06810	COG1178	ABC-type Fe3 transport system permease component
GPW70_RS06815	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPW70_RS06820	COG3028	Belongs to the UPF0307 family
GPW70_RS06825	COG0312	modulator of DNA gyrase
GPW70_RS06830	COG2239	Acts as a magnesium transporter
GPW70_RS06835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW70_RS06845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW70_RS06850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW70_RS06860	COG1137	ATPase activity
GPW70_RS06865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPW70_RS06880	COG0517	IMP dehydrogenase activity
GPW70_RS06880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPW70_RS06890	COG1127	ABC transporter
GPW70_RS06895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPW70_RS06900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW70_RS06905	COG2854	intermembrane phospholipid transfer
GPW70_RS06915	COG5007	Belongs to the BolA IbaG family
GPW70_RS06920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPW70_RS06925	COG0204	Acyl-transferase
GPW70_RS06935	COG0251	oxidation-reduction process
GPW70_RS06940	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPW70_RS06945	COG0540	Belongs to the ATCase OTCase family
GPW70_RS06950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPW70_RS06955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPW70_RS06960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPW70_RS06965	COG0564	pseudouridine synthase activity
GPW70_RS06970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW70_RS06975	COG4269	membrane
GPW70_RS06985	COG0525	valine-tRNA ligase activity
GPW70_RS06990	COG2927	DNA polymerase III (CHI subunit)
GPW70_RS06995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW70_RS07000	COG0795	lipopolysaccharide-transporting ATPase activity
GPW70_RS07005	COG0795	lipopolysaccharide-transporting ATPase activity
GPW70_RS07025	COG3437	response regulator, receiver
GPW70_RS07070	COG0066	3-isopropylmalate dehydratase activity
GPW70_RS07075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPW70_RS07080	COG0473	3-isopropylmalate dehydrogenase activity
GPW70_RS07085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW70_RS07105	COG0583	DNA-binding transcription factor activity
GPW70_RS07110	COG1022	Amp-dependent synthetase and ligase
GPW70_RS07115	COG0028	Belongs to the TPP enzyme family
GPW70_RS07120	COG0440	acetolactate synthase activity
GPW70_RS07125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW70_RS07130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPW70_RS07135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPW70_RS07145	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPW70_RS07155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW70_RS07160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW70_RS07175	COG0354	folic acid binding
GPW70_RS07180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPW70_RS07190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPW70_RS07195	COG1595	DNA-templated transcription, initiation
GPW70_RS07200	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPW70_RS07205	COG3026	antisigma factor binding
GPW70_RS07210	COG3086	response to oxidative stress
GPW70_RS07215	COG0481	GTPase activity
GPW70_RS07220	COG0681	Belongs to the peptidase S26 family
GPW70_RS07225	COG0571	ribonuclease III activity
GPW70_RS07230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPW70_RS07235	COG1381	Involved in DNA repair and RecF pathway recombination
GPW70_RS07240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPW70_RS07245	COG0736	holo-[acyl-carrier-protein] synthase activity
GPW70_RS07270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW70_RS07275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW70_RS07280	COG3956	TIGRFAM MazG family protein
GPW70_RS07285	COG0504	CTP synthase activity
GPW70_RS07290	COG0148	phosphopyruvate hydratase activity
GPW70_RS07295	COG0617	tRNA 3'-terminal CCA addition
GPW70_RS07300	COG3267	Type II secretory pathway component ExeA
GPW70_RS07300	COG3409	Peptidoglycan-binding domain 1 protein
GPW70_RS07310	COG4991	sh3 domain protein
GPW70_RS07315	COG0306	phosphate transporter
GPW70_RS07320	COG1392	Phosphate transport regulator
GPW70_RS07325	COG3025	triphosphatase activity
GPW70_RS07335	COG0840	transmembrane signaling receptor activity
GPW70_RS07340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPW70_RS07350	COG1538	Outer membrane efflux protein
GPW70_RS07355	COG0494	nUDIX hydrolase
GPW70_RS07360	COG3151	Protein conserved in bacteria
GPW70_RS07370	COG3150	esterase
GPW70_RS07375	COG0187	DNA topoisomerase II activity
GPW70_RS07380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPW70_RS07385	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPW70_RS07390	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPW70_RS07395	COG0237	dephospho-CoA kinase activity
GPW70_RS07405	COG1459	type II secretion system
GPW70_RS07410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW70_RS07420	COG0157	Belongs to the NadC ModD family
GPW70_RS07435	COG0716	FMN binding
GPW70_RS07440	COG4974	Belongs to the 'phage' integrase family
GPW70_RS07445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW70_RS07450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPW70_RS07455	COG2186	Transcriptional regulator
GPW70_RS07460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPW70_RS07465	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW70_RS07470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW70_RS07480	COG0275	rRNA processing
GPW70_RS07485	COG3116	cell division
GPW70_RS07490	COG0768	penicillin binding
GPW70_RS07495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPW70_RS07500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPW70_RS07505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPW70_RS07510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPW70_RS07515	COG0772	Belongs to the SEDS family
GPW70_RS07520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPW70_RS07525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW70_RS07530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPW70_RS07535	COG0849	cell division
GPW70_RS07540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPW70_RS07545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPW70_RS07555	COG0653	protein targeting
GPW70_RS07560	COG0494	nUDIX hydrolase
GPW70_RS07565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPW70_RS07575	COG0505	Belongs to the CarA family
GPW70_RS07580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPW70_RS07600	COG0730	response to heat
GPW70_RS07605	COG0583	DNA-binding transcription factor activity
GPW70_RS07610	COG2860	membrane
GPW70_RS07615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPW70_RS07625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPW70_RS07635	COG0493	'glutamate synthase
GPW70_RS07640	COG0070	glutamate synthase
GPW70_RS07640	COG0067	glutamate synthase
GPW70_RS07640	COG0069	glutamate synthase activity
GPW70_RS07650	COG0069	glutamate synthase activity
GPW70_RS07650	COG0070	glutamate synthase
GPW70_RS07650	COG0067	glutamate synthase
GPW70_RS07655	COG1242	4 iron, 4 sulfur cluster binding
GPW70_RS07660	COG3706	GGDEF domain
GPW70_RS07660	COG4251	negative regulation of phosphorylation
GPW70_RS07660	COG5001	Diguanylate cyclase
GPW70_RS07660	COG2203	Gaf domain
GPW70_RS07665	COG5002	protein histidine kinase activity
GPW70_RS07665	COG0784	Response regulator, receiver
GPW70_RS07665	COG2198	Histidine kinase
GPW70_RS07670	COG0745	RESPONSE REGULATOR receiver
GPW70_RS07680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW70_RS07700	COG0083	homoserine kinase activity
GPW70_RS07705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPW70_RS07710	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPW70_RS07715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPW70_RS07720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPW70_RS07735	COG1115	amino acid carrier protein
GPW70_RS07750	COG0084	hydrolase, TatD family'
GPW70_RS07755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW70_RS07765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPW70_RS07770	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPW70_RS07775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPW70_RS07795	COG3385	transposase activity
GPW70_RS07805	COG0560	Phosphoserine phosphatase
GPW70_RS07815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPW70_RS07820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW70_RS07825	COG1022	Amp-dependent synthetase and ligase
GPW70_RS07840	COG3250	beta-galactosidase activity
GPW70_RS07845	COG1609	Transcriptional regulator
GPW70_RS07850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW70_RS07865	COG0189	ligase activity
GPW70_RS07865	COG0569	domain protein
GPW70_RS07870	COG0456	acetyltransferase
GPW70_RS07880	COG2171	N-acyltransferase activity
GPW70_RS07885	COG3141	response to X-ray
GPW70_RS07900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPW70_RS07905	COG1074	ATP-dependent DNA helicase activity
GPW70_RS07910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPW70_RS07920	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPW70_RS07920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW70_RS07930	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPW70_RS07935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPW70_RS07940	COG2166	iron-sulfur cluster assembly
GPW70_RS07945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW70_RS07950	COG0693	protein deglycase activity
GPW70_RS07955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPW70_RS07960	COG3248	Nucleoside-binding outer membrane protein
GPW70_RS07970	COG1595	DNA-templated transcription, initiation
GPW70_RS07980	COG2211	Major facilitator Superfamily
GPW70_RS07985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW70_RS07995	COG2813	Specifically methylates the guanine in position
GPW70_RS08000	COG0271	Belongs to the BolA IbaG family
GPW70_RS08005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW70_RS08010	COG1805	sodium ion transport
GPW70_RS08015	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW70_RS08020	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW70_RS08025	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW70_RS08030	COG2871	sodium ion transport
GPW70_RS08035	COG1477	protein flavinylation
GPW70_RS08045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPW70_RS08055	COG3706	GGDEF domain
GPW70_RS08060	COG0733	neurotransmitter:sodium symporter activity
GPW70_RS08065	COG3385	transposase activity
GPW70_RS08075	COG0189	ligase activity
GPW70_RS08080	COG0189	ligase activity
GPW70_RS08080	COG4067	protein conserved in archaea
GPW70_RS08085	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW70_RS08090	COG2252	PERMEase
GPW70_RS08095	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPW70_RS08110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPW70_RS08115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPW70_RS08120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPW70_RS08125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW70_RS08125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW70_RS08140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPW70_RS08145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW70_RS08150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPW70_RS08155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPW70_RS08165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPW70_RS08170	COG0024	Methionine aminopeptidase
GPW70_RS08175	COG0052	Belongs to the universal ribosomal protein uS2 family
GPW70_RS08180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPW70_RS08185	COG0528	UMP kinase activity
GPW70_RS08190	COG0233	cytoplasmic translational termination
GPW70_RS08195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPW70_RS08200	COG0575	Belongs to the CDS family
GPW70_RS08205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPW70_RS08210	COG0750	zinc metalloprotease
GPW70_RS08220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPW70_RS08225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW70_RS08230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW70_RS08235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW70_RS08240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW70_RS08245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPW70_RS08250	COG0587	DNA-directed DNA polymerase activity
GPW70_RS08255	COG0825	malonyl-CoA metabolic process
GPW70_RS08265	COG0037	tRNA processing
GPW70_RS08275	COG3479	Phenolic acid decarboxylase
GPW70_RS08280	COG0347	Belongs to the P(II) protein family
GPW70_RS08290	COG1388	LysM domain
GPW70_RS08290	COG0741	lytic transglycosylase activity
GPW70_RS08295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW70_RS08300	COG2226	methyltransferase
GPW70_RS08305	COG0328	RNA-DNA hybrid ribonuclease activity
GPW70_RS08310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW70_RS08320	COG1960	acyl-CoA dehydrogenase activity
GPW70_RS08325	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW70_RS08330	COG0121	glutamine amidotransferase
GPW70_RS08335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPW70_RS08340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPW70_RS08345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPW70_RS08350	COG3706	GGDEF domain
GPW70_RS08355	COG1187	pseudouridine synthase activity
GPW70_RS08360	COG2840	Smr protein MutS2
GPW70_RS08390	COG2217	Heavy metal translocating P-type atpase
GPW70_RS08390	COG2608	mercury ion transmembrane transporter activity
GPW70_RS08395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW70_RS08410	COG1629	transport
GPW70_RS08410	COG4774	siderophore transport
GPW70_RS08415	COG2375	cellular response to nickel ion
GPW70_RS08420	COG3433	isochorismatase activity
GPW70_RS08420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPW70_RS08420	COG2226	methyltransferase
GPW70_RS08455	COG0835	chemotaxis
GPW70_RS08455	COG0784	Response regulator, receiver
GPW70_RS08460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW70_RS08465	COG1815	bacterial-type flagellum-dependent cell motility
GPW70_RS08470	COG1558	bacterial-type flagellum-dependent cell motility
GPW70_RS08475	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPW70_RS08480	COG1749	Flagellar hook protein flgE
GPW70_RS08485	COG4787	bacterial-type flagellum-dependent cell motility
GPW70_RS08490	COG4786	Flagellar basal body rod
GPW70_RS08495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPW70_RS08500	COG1706	bacterial-type flagellum-dependent cell motility
GPW70_RS08505	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPW70_RS08505	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPW70_RS08520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW70_RS08525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW70_RS08610	COG0012	GTP binding
GPW70_RS08615	COG0193	aminoacyl-tRNA hydrolase activity
GPW70_RS08620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPW70_RS08625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPW70_RS08630	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPW70_RS08635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPW70_RS08640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPW70_RS08645	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW70_RS08650	COG3094	Invasion gene expression up-regulator, SirB
GPW70_RS08655	COG2912	Transglutaminase-like superfamily
GPW70_RS08660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPW70_RS08665	COG0737	Belongs to the 5'-nucleotidase family
GPW70_RS08670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPW70_RS08675	COG2233	PERMEase
GPW70_RS08685	COG3385	transposase activity
GPW70_RS08700	COG1393	Belongs to the ArsC family
GPW70_RS08705	COG4783	chaperone-mediated protein folding
GPW70_RS08725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPW70_RS08735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW70_RS08740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPW70_RS08750	COG3385	transposase activity
GPW70_RS08755	COG2837	iron assimilation
GPW70_RS08775	COG1393	Belongs to the ArsC family
GPW70_RS08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW70_RS08785	COG1876	peptidase activity
GPW70_RS08800	COG3385	transposase activity
GPW70_RS08805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW70_RS08810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW70_RS08815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW70_RS08820	COG1334	flagellar protein FlaG
GPW70_RS08825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPW70_RS08835	COG1516	flagellar protein fliS
GPW70_RS08840	COG2204	response regulator
GPW70_RS08845	COG4191	Histidine kinase
GPW70_RS08850	COG2204	response regulator
GPW70_RS08855	COG1677	Flagellar hook-basal body complex protein FliE
GPW70_RS08865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPW70_RS08870	COG1317	bacterial-type flagellum organization
GPW70_RS08895	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW70_RS08920	COG1987	bacterial-type flagellum assembly
GPW70_RS08925	COG1684	flagellar biosynthetic protein fliR
GPW70_RS08940	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW70_RS08945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPW70_RS08950	COG2860	membrane
GPW70_RS08955	COG3101	peptidyl-lysine hydroxylation
GPW70_RS08965	COG0431	NADPH-dependent FMN reductase
GPW70_RS08970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW70_RS08970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPW70_RS08975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW70_RS08980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW70_RS08985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW70_RS08990	COG3385	transposase activity
GPW70_RS08995	COG0735	belongs to the Fur family
GPW70_RS09005	COG0583	DNA-binding transcription factor activity
GPW70_RS09010	COG1380	Effector of murein hydrolase LrgA
GPW70_RS09015	COG1346	cytolysis
GPW70_RS09030	COG0596	Alpha beta hydrolase
GPW70_RS09035	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPW70_RS09040	COG0033	Phosphoglucomutase
GPW70_RS09050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPW70_RS09055	COG0372	Belongs to the citrate synthase family
GPW70_RS09060	COG2009	succinate dehydrogenase
GPW70_RS09065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPW70_RS09070	COG1053	succinate dehydrogenase
GPW70_RS09080	COG0567	Dehydrogenase, E1 component
GPW70_RS09085	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW70_RS09090	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW70_RS09100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPW70_RS09105	COG1121	(ABC) transporter
GPW70_RS09110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPW70_RS09115	COG4977	sequence-specific DNA binding
GPW70_RS09120	COG1918	ferrous iron import across plasma membrane
GPW70_RS09140	COG0018	arginyl-trna synthetase
GPW70_RS09150	COG1025	Belongs to the peptidase M16 family
GPW70_RS09155	COG2062	phosphohistidine phosphatase, SixA
GPW70_RS09170	COG0455	bacterial-type flagellum organization
GPW70_RS09185	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPW70_RS09190	COG0643	Histidine kinase
GPW70_RS09190	COG2198	Histidine kinase
GPW70_RS09195	COG2201	protein-glutamate methylesterase activity
GPW70_RS09200	COG1192	Involved in chromosome partitioning
GPW70_RS09210	COG0835	chemotaxis
GPW70_RS09220	COG4133	protoheme IX ABC transporter activity
GPW70_RS09225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW70_RS09230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW70_RS09240	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPW70_RS09245	COG1138	Cytochrome C-type biogenesis protein
GPW70_RS09250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPW70_RS09255	COG4235	cytochrome complex assembly
GPW70_RS09255	COG3088	subunit of a heme lyase
GPW70_RS09265	COG2853	Lipoprotein
GPW70_RS09285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPW70_RS09290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW70_RS09295	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPW70_RS09310	COG3083	sulfuric ester hydrolase activity
GPW70_RS09320	COG3081	Nucleoid-associated protein
GPW70_RS09330	COG1757	Na H antiporter
GPW70_RS09335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW70_RS09340	COG2095	MarC family integral membrane protein
GPW70_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
GPW70_RS09345	COG1454	alcohol dehydrogenase
GPW70_RS09355	COG0659	secondary active sulfate transmembrane transporter activity
GPW70_RS09360	COG1530	ribonuclease E activity
GPW70_RS09365	COG0564	pseudouridine synthase activity
GPW70_RS09370	COG0424	maF-like protein
GPW70_RS09375	COG1399	metal-binding, possibly nucleic acid-binding protein
GPW70_RS09380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPW70_RS09385	COG0416	fatty acid biosynthetic process
GPW70_RS09390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW70_RS09395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPW70_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
GPW70_RS09405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPW70_RS09410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW70_RS09415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW70_RS09420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPW70_RS09425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPW70_RS09435	COG0084	hydrolase, TatD family'
GPW70_RS09440	COG1263	PTS System
GPW70_RS09440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW70_RS09450	COG0733	neurotransmitter:sodium symporter activity
GPW70_RS09465	COG4667	esterase of the alpha-beta hydrolase superfamily
GPW70_RS09475	COG1940	carbohydrate kinase activity
GPW70_RS09480	COG0835	chemotaxis
GPW70_RS09480	COG0784	Response regulator, receiver
GPW70_RS09495	COG2226	methyltransferase
GPW70_RS09505	COG0676	glucose-6-phosphate 1-epimerase activity
GPW70_RS09510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW70_RS09525	COG3139	Protein of unknown function (DUF1315)
GPW70_RS09530	COG0252	asparaginase activity
GPW70_RS09535	COG0616	signal peptide processing
GPW70_RS09540	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW70_RS09540	COG1902	pentaerythritol trinitrate reductase activity
GPW70_RS09545	COG0788	formyltetrahydrofolate deformylase activity
GPW70_RS09555	COG1199	ATP-dependent helicase activity
GPW70_RS09560	COG1214	PFAM Peptidase M22, glycoprotease
GPW70_RS09575	COG2267	carboxylic ester hydrolase activity
GPW70_RS09580	COG0318	PFAM AMP-dependent synthetase and ligase
GPW70_RS09585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPW70_RS09600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPW70_RS09605	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPW70_RS09610	COG0436	Aminotransferase
GPW70_RS09615	COG1169	isochorismate synthase
GPW70_RS09620	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPW70_RS09625	COG0596	Alpha beta hydrolase
GPW70_RS09635	COG1441	menaquinone biosynthetic process
GPW70_RS09645	COG3135	benzoate transporter
GPW70_RS09670	COG3015	lipoprotein NlpE involved in copper resistance
GPW70_RS09675	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPW70_RS09680	COG2894	cell division
GPW70_RS09685	COG0850	regulation of cytokinetic process
GPW70_RS09690	COG3100	YcgL domain-containing protein
GPW70_RS09695	COG2951	lytic endotransglycosylase activity
GPW70_RS09705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW70_RS09710	COG3325	Belongs to the glycosyl hydrolase 18 family
GPW70_RS09710	COG3469	chitinase activity
GPW70_RS09715	COG3005	denitrification pathway
GPW70_RS09720	COG0243	molybdopterin cofactor binding
GPW70_RS09740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW70_RS09750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPW70_RS09785	COG4589	Belongs to the CDS family
GPW70_RS09795	COG5001	Diguanylate cyclase
GPW70_RS09795	COG3300	MHYT domain
GPW70_RS09810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPW70_RS09815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW70_RS09820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW70_RS09825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW70_RS09835	COG4191	Histidine kinase
GPW70_RS09845	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPW70_RS09855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPW70_RS09860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPW70_RS09865	COG0776	regulation of translation
GPW70_RS09870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW70_RS09875	COG1555	photosystem II stabilization
GPW70_RS09880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPW70_RS09885	COG0539	negative regulation of cytoplasmic translation
GPW70_RS09890	COG0776	regulation of translation
GPW70_RS09895	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPW70_RS09900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPW70_RS09905	COG0284	orotidine-5'-phosphate decarboxylase activity
GPW70_RS09920	COG0583	DNA-binding transcription factor activity
GPW70_RS09930	COG0686	Belongs to the AlaDH PNT family
GPW70_RS09945	COG1674	ftsk spoiiie
GPW70_RS09950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPW70_RS09955	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW70_RS09960	COG2186	Transcriptional regulator
GPW70_RS09975	COG0537	adenosine 5'-monophosphoramidase activity
GPW70_RS10005	COG1252	NADH dehydrogenase
GPW70_RS10025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPW70_RS10035	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW70_RS10040	COG1136	(ABC) transporter
GPW70_RS10045	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW70_RS10060	COG2333	competence protein COMEC
GPW70_RS10060	COG0658	competence protein
GPW70_RS10065	COG1132	(ABC) transporter
GPW70_RS10070	COG1663	tetraacyldisaccharide 4'-kinase activity
GPW70_RS10080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPW70_RS10085	COG2719	SpoVR family
GPW70_RS10090	COG2718	Belongs to the UPF0229 family
GPW70_RS10095	COG2766	serine protein kinase
GPW70_RS10100	COG3385	transposase activity
GPW70_RS10105	COG3013	Belongs to the UPF0304 family
GPW70_RS10115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPW70_RS10120	COG0840	transmembrane signaling receptor activity
GPW70_RS10130	COG1882	Formate acetyltransferase
GPW70_RS10150	COG4215	(ABC) transporter
GPW70_RS10155	COG4160	amino acid transport
GPW70_RS10160	COG0708	Exodeoxyribonuclease III
GPW70_RS10170	COG3923	Primosomal replication protein n
GPW70_RS10175	COG0730	response to heat
GPW70_RS10180	COG1199	ATP-dependent helicase activity
GPW70_RS10185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW70_RS10190	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW70_RS10200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW70_RS10205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW70_RS10210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW70_RS10215	COG0215	cysteine-tRNA ligase activity
GPW70_RS10220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPW70_RS10225	COG0632	four-way junction helicase activity
GPW70_RS10230	COG2255	four-way junction helicase activity
GPW70_RS10235	COG1271	oxidase subunit
GPW70_RS10240	COG1294	oxidase, subunit
GPW70_RS10245	COG4890	Cyd operon protein YbgT
GPW70_RS10250	COG3790	cyd operon protein YbgE
GPW70_RS10255	COG0824	Thioesterase
GPW70_RS10260	COG0811	peptide transport
GPW70_RS10275	COG0823	Involved in the tonB-independent uptake of proteins
GPW70_RS10280	COG2885	chlorophyll binding
GPW70_RS10290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPW70_RS10300	COG0784	Response regulator, receiver
GPW70_RS10300	COG5002	protein histidine kinase activity
GPW70_RS10310	COG1482	cell wall glycoprotein biosynthetic process
GPW70_RS10315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW70_RS10315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW70_RS10315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW70_RS10320	COG2207	Transcriptional regulator
GPW70_RS10330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW70_RS10335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW70_RS10340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW70_RS10350	COG1012	belongs to the aldehyde dehydrogenase family
GPW70_RS10355	COG3284	Transcriptional regulator
GPW70_RS10360	COG4628	conserved protein (DUF2132)
GPW70_RS10370	COG0415	Belongs to the DNA photolyase family
GPW70_RS10395	COG4409	exo-alpha-(2->6)-sialidase activity
GPW70_RS10400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW70_RS10405	COG1940	carbohydrate kinase activity
GPW70_RS10410	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPW70_RS10420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW70_RS10425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW70_RS10430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW70_RS10435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW70_RS10440	COG1737	Transcriptional regulator
GPW70_RS10445	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW70_RS10450	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW70_RS10460	COG4932	domain protein
GPW70_RS10460	COG5492	domain, Protein
GPW70_RS10485	COG0596	Alpha beta hydrolase
GPW70_RS10495	COG3064	Membrane
GPW70_RS10600	COG4789	Type iii secretion
GPW70_RS10605	COG4792	protein secretion
GPW70_RS10635	COG3710	Transcriptional regulator
GPW70_RS10645	COG4790	Type iii secretion
GPW70_RS10725	COG0582	viral genome integration into host DNA
GPW70_RS10740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW70_RS10750	COG3008	intermembrane lipid transfer
GPW70_RS10750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW70_RS10755	COG2995	paraquat-inducible protein a
GPW70_RS10760	COG0668	transmembrane transport
GPW70_RS10780	COG1309	transcriptional regulator
GPW70_RS10785	COG1012	belongs to the aldehyde dehydrogenase family
GPW70_RS10805	COG1960	acyl-CoA dehydrogenase activity
GPW70_RS10810	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW70_RS10815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPW70_RS10820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPW70_RS10825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPW70_RS10835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPW70_RS10845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW70_RS10850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW70_RS10855	COG0297	glycogen (starch) synthase activity
GPW70_RS10875	COG3070	regulator of competence-specific genes
GPW70_RS10880	COG1609	Transcriptional regulator
GPW70_RS10890	COG0745	RESPONSE REGULATOR receiver
GPW70_RS10895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW70_RS10900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW70_RS10905	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPW70_RS10910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPW70_RS10915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPW70_RS10920	COG1979	alcohol dehydrogenase
GPW70_RS10925	COG2207	Transcriptional regulator
GPW70_RS10940	COG1280	lysine exporter protein (LysE YggA)
GPW70_RS10945	COG1032	radical SAM domain protein
GPW70_RS10950	COG5001	Diguanylate cyclase
GPW70_RS10970	COG0583	DNA-binding transcription factor activity
GPW70_RS10975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPW70_RS10985	COG2350	Protein conserved in bacteria
GPW70_RS10990	COG1607	acyl-coa hydrolase
GPW70_RS10995	COG2917	probably involved in intracellular septation
GPW70_RS11005	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW70_RS11010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW70_RS11020	COG2116	formate transmembrane transporter activity
GPW70_RS11025	COG4459	periplasmic nitrate reductase
GPW70_RS11030	COG3005	denitrification pathway
GPW70_RS11035	COG0243	molybdopterin cofactor binding
GPW70_RS11050	COG1227	inorganic diphosphatase activity
GPW70_RS11065	COG4172	Belongs to the ABC transporter superfamily
GPW70_RS11075	COG4171	peptide transport system, permease
GPW70_RS11080	COG4168	peptide transport system, permease
GPW70_RS11090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPW70_RS11095	COG1842	Phage shock protein A
GPW70_RS11110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW70_RS11125	COG2818	Glycosylase
GPW70_RS11130	COG0626	cystathionine gamma-synthase activity
GPW70_RS11140	COG0733	neurotransmitter:sodium symporter activity
GPW70_RS11145	COG0564	pseudouridine synthase activity
GPW70_RS11150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPW70_RS11155	COG4136	ATPase activity
GPW70_RS11160	COG4135	transport system, permease component
GPW70_RS11165	COG4134	Bacterial extracellular solute-binding protein
GPW70_RS11175	COG3313	Fe-S protein
GPW70_RS11185	COG0842	Transport permease protein
GPW70_RS11190	COG1131	(ABC) transporter
GPW70_RS11195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW70_RS11200	COG0814	amino acid
GPW70_RS11210	COG2239	Acts as a magnesium transporter
GPW70_RS11230	COG4934	collagen metabolic process
GPW70_RS11265	COG0840	transmembrane signaling receptor activity
GPW70_RS11280	COG5001	Diguanylate cyclase
GPW70_RS11280	COG4251	negative regulation of phosphorylation
GPW70_RS11280	COG3706	GGDEF domain
GPW70_RS11280	COG2203	Gaf domain
GPW70_RS11285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPW70_RS11290	COG5002	protein histidine kinase activity
GPW70_RS11305	COG1061	Type III restriction enzyme res subunit
GPW70_RS11310	COG1187	pseudouridine synthase activity
GPW70_RS11315	COG2814	Major facilitator Superfamily
GPW70_RS11325	COG0702	epimerase
GPW70_RS11330	COG0534	Mate efflux family protein
GPW70_RS11335	COG4181	ATPase activity
GPW70_RS11350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW70_RS11360	COG1748	Saccharopine dehydrogenase
GPW70_RS11365	COG0019	diaminopimelate decarboxylase activity
GPW70_RS11375	COG1538	Outer membrane efflux protein
GPW70_RS11385	COG3385	transposase activity
GPW70_RS11395	COG1538	Outer membrane efflux protein
GPW70_RS11400	COG1566	PFAM secretion protein HlyD family protein
GPW70_RS11405	COG2814	Major facilitator Superfamily
GPW70_RS11410	COG0840	transmembrane signaling receptor activity
GPW70_RS11415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPW70_RS11425	COG3501	Rhs element vgr protein
GPW70_RS11445	COG1280	lysine exporter protein (LysE YggA)
GPW70_RS11450	COG1115	amino acid carrier protein
GPW70_RS11465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW70_RS11470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW70_RS11475	COG1177	transmembrane transport
GPW70_RS11480	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPW70_RS11485	COG3842	ATPase activity
GPW70_RS11505	COG0037	tRNA processing
GPW70_RS11510	COG0589	response to stress
GPW70_RS11515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW70_RS11530	COG2217	Heavy metal translocating P-type atpase
GPW70_RS11540	COG2010	Cytochrome c
GPW70_RS11570	COG2205	protein histidine kinase activity
GPW70_RS11570	COG0784	Response regulator, receiver
GPW70_RS11595	COG2994	toxin metabolic process
GPW70_RS11610	COG1073	alpha beta
GPW70_RS11610	COG3064	Membrane
GPW70_RS11610	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPW70_RS11700	COG4128	Pfam Zonular occludens toxin
GPW70_RS11745	COG4128	Pfam Zonular occludens toxin
GPW70_RS11790	COG3120	sequence-specific DNA binding
GPW70_RS11795	COG1067	ATP-dependent peptidase activity
GPW70_RS11800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW70_RS11825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW70_RS11825	COG0116	Belongs to the methyltransferase superfamily
GPW70_RS11835	COG0167	dihydroorotate dehydrogenase activity
GPW70_RS11850	COG0308	aminopeptidase N
GPW70_RS11865	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPW70_RS11870	COG1956	GAF domain-containing protein
GPW70_RS11875	COG1132	(ABC) transporter
GPW70_RS11880	COG2995	paraquat-inducible protein a
GPW70_RS11885	COG3008	intermembrane lipid transfer
GPW70_RS11890	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPW70_RS11890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW70_RS11895	COG2996	Protein conserved in bacteria
GPW70_RS11910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW70_RS11920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPW70_RS11935	COG0437	4 iron, 4 sulfur cluster binding
GPW70_RS11940	COG0243	molybdopterin cofactor binding
GPW70_RS11940	COG3383	formate dehydrogenase (NAD+) activity
GPW70_RS11970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPW70_RS11975	COG0488	(ABC) transporter
GPW70_RS11980	COG3852	Histidine kinase
GPW70_RS11985	COG2204	response regulator
GPW70_RS11995	COG4662	Binding-protein-dependent transport system inner membrane component
GPW70_RS12000	COG3842	ATPase activity
GPW70_RS12005	COG0746	molybdenum cofactor guanylyltransferase activity
GPW70_RS12020	COG1940	carbohydrate kinase activity
GPW70_RS12035	COG0840	transmembrane signaling receptor activity
GPW70_RS12040	COG0791	NLP P60 protein
GPW70_RS12060	COG0534	Mate efflux family protein
GPW70_RS12070	COG1793	dna ligase
GPW70_RS12080	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW70_RS12085	COG0848	biopolymer transport protein
GPW70_RS12090	COG0811	peptide transport
GPW70_RS12095	COG0811	peptide transport
GPW70_RS12110	COG1175	transmembrane transport
GPW70_RS12115	COG0395	ABC-type sugar transport system, permease component
GPW70_RS12120	COG3842	ATPase activity
GPW70_RS12125	COG1349	DNA-binding transcription factor activity
GPW70_RS12130	COG0584	glycerophosphoryl diester phosphodiesterase
GPW70_RS12135	COG2731	YhcH YjgK YiaL family protein
GPW70_RS12140	COG0251	oxidation-reduction process
GPW70_RS12145	COG1609	Transcriptional regulator
GPW70_RS12150	COG2723	6-phospho-beta-galactosidase activity
GPW70_RS12155	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPW70_RS12180	COG1136	(ABC) transporter
GPW70_RS12180	COG0577	efflux transmembrane transporter activity
GPW70_RS12185	COG1136	(ABC) transporter
GPW70_RS12185	COG0577	efflux transmembrane transporter activity
GPW70_RS12190	COG1136	(ABC) transporter
GPW70_RS12190	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW70_RS12195	COG1294	oxidase, subunit
GPW70_RS12200	COG1271	oxidase subunit
GPW70_RS12250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW70_RS12265	COG3527	Alpha-acetolactate decarboxylase
GPW70_RS12280	COG2199	diguanylate cyclase activity
GPW70_RS12280	COG2200	EAL domain
GPW70_RS12285	COG3706	GGDEF domain
GPW70_RS12290	COG2017	converts alpha-aldose to the beta-anomer
GPW70_RS12295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPW70_RS12300	COG1085	galactose-1-phosphate uridylyltransferase
GPW70_RS12325	COG0745	RESPONSE REGULATOR receiver
GPW70_RS12325	COG3706	GGDEF domain
GPW70_RS12345	COG0784	Response regulator, receiver
GPW70_RS12345	COG0835	chemotaxis
GPW70_RS12355	COG4565	transcriptional regulatory protein
GPW70_RS12360	COG3290	protein histidine kinase activity
GPW70_RS12375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW70_RS12395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPW70_RS12400	COG3063	Type IV pilus biogenesis stability protein PilW
GPW70_RS12415	COG1451	nucleotide metabolic process
GPW70_RS12425	COG0583	DNA-binding transcription factor activity
GPW70_RS12445	COG0513	Belongs to the DEAD box helicase family
GPW70_RS12455	COG0840	transmembrane signaling receptor activity
GPW70_RS12460	COG0840	transmembrane signaling receptor activity
GPW70_RS12465	COG0835	chemotaxis
GPW70_RS12470	COG2201	protein-glutamate methylesterase activity
GPW70_RS12480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW70_RS12490	COG2198	Histidine kinase
GPW70_RS12490	COG0643	Histidine kinase
GPW70_RS12510	COG2076	Multidrug Resistance protein
GPW70_RS12515	COG0415	Belongs to the DNA photolyase family
GPW70_RS12520	COG0477	Major facilitator Superfamily
GPW70_RS12525	COG0583	DNA-binding transcription factor activity
GPW70_RS12535	COG0402	S-adenosylhomocysteine deaminase activity
GPW70_RS12540	COG0095	Lipoate-protein ligase
GPW70_RS12545	COG0443	Heat shock 70 kDa protein
GPW70_RS12560	COG1643	Atp-dependent helicase
GPW70_RS12595	COG0443	Heat shock 70 kDa protein
GPW70_RS12600	COG0443	Heat shock 70 kDa protein
GPW70_RS12605	COG3706	GGDEF domain
GPW70_RS12635	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPW70_RS12640	COG0602	queuosine metabolic process
GPW70_RS12645	COG0561	phosphatase activity
GPW70_RS12655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW70_RS12660	COG4597	amino acid ABC transporter
GPW70_RS12665	COG0765	amino acid transport
GPW70_RS12670	COG1126	abc transporter atp-binding protein
GPW70_RS12675	COG0670	Belongs to the BI1 family
GPW70_RS12680	COG2920	part of a sulfur-relay system
GPW70_RS12685	COG1254	Belongs to the acylphosphatase family
GPW70_RS12690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW70_RS12695	COG3706	GGDEF domain
GPW70_RS12705	COG3850	Histidine kinase
GPW70_RS12705	COG4999	Histidine kinase
GPW70_RS12705	COG2205	protein histidine kinase activity
GPW70_RS12705	COG3437	response regulator, receiver
GPW70_RS12710	COG3437	response regulator, receiver
GPW70_RS12715	COG0625	glutathione transferase activity
GPW70_RS12725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPW70_RS12735	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW70_RS12765	COG0372	Belongs to the citrate synthase family
GPW70_RS12770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPW70_RS12775	COG2186	Transcriptional regulator
GPW70_RS12810	COG1129	ABC transporter
GPW70_RS12835	COG0745	RESPONSE REGULATOR receiver
GPW70_RS12840	COG5002	protein histidine kinase activity
GPW70_RS12845	COG3713	MltA-interacting MipA family protein
GPW70_RS12850	COG2990	Protein conserved in bacteria
GPW70_RS12860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW70_RS12860	COG4191	Histidine kinase
GPW70_RS12865	COG0471	metal ion transport
GPW70_RS12875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW70_RS12895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW70_RS12900	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPW70_RS12905	COG3768	UPF0283 membrane protein
GPW70_RS12910	COG3106	COG3106 Predicted ATPase
GPW70_RS12925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW70_RS12930	COG0494	nUDIX hydrolase
GPW70_RS12935	COG0814	amino acid
GPW70_RS12940	COG1760	l-serine dehydratase
GPW70_RS12945	COG0720	synthase
GPW70_RS12955	COG0017	Asparaginyl-tRNA synthetase
GPW70_RS12960	COG3385	transposase activity
GPW70_RS12965	COG0351	phosphomethylpyrimidine kinase
GPW70_RS12965	COG0352	thiamine-phosphate diphosphorylase activity
GPW70_RS12970	COG2770	Histidine kinase
GPW70_RS12970	COG3437	response regulator, receiver
GPW70_RS12980	COG1448	Aminotransferase
GPW70_RS13000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPW70_RS13005	COG2943	transferase activity, transferring hexosyl groups
GPW70_RS13010	COG1609	Transcriptional regulator
GPW70_RS13015	COG3394	polysaccharide catabolic process
GPW70_RS13020	COG1486	melibiose metabolic process
GPW70_RS13025	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPW70_RS13035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPW70_RS13040	COG0726	polysaccharide deacetylase
GPW70_RS13045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPW70_RS13050	COG1846	Transcriptional regulator
GPW70_RS13075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW70_RS13090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW70_RS13095	COG3108	Peptidase M15
GPW70_RS13125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW70_RS13135	COG2814	Major facilitator Superfamily
GPW70_RS13155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW70_RS13160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW70_RS13165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW70_RS13195	COG0840	transmembrane signaling receptor activity
GPW70_RS13210	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPW70_RS13215	COG4139	cobalamin transport
GPW70_RS13220	COG2988	succinylglutamate desuccinylase activity
GPW70_RS13235	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPW70_RS13240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPW70_RS13245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW70_RS13255	COG2925	Exonuclease
GPW70_RS13265	COG1346	cytolysis
GPW70_RS13270	COG0295	cytidine deaminase activity
GPW70_RS13290	COG0500	methyltransferase
GPW70_RS13305	COG0776	regulation of translation
GPW70_RS13310	COG0072	phenylalanine-tRNA ligase activity
GPW70_RS13310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW70_RS13315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPW70_RS13325	COG0745	RESPONSE REGULATOR receiver
GPW70_RS13325	COG3706	GGDEF domain
GPW70_RS13355	COG0322	excinuclease ABC activity
GPW70_RS13360	COG2197	response regulator
GPW70_RS13365	COG0417	DNA replication proofreading
GPW70_RS13370	COG5001	Diguanylate cyclase
GPW70_RS13380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW70_RS13400	COG1228	amidohydrolase
GPW70_RS13405	COG0010	Belongs to the arginase family
GPW70_RS13410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPW70_RS13415	COG2986	histidine ammonia-lyase
GPW70_RS13435	COG0277	FAD linked oxidase domain protein
GPW70_RS13435	COG0247	lactate metabolic process
GPW70_RS13450	COG2885	chlorophyll binding
GPW70_RS13470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPW70_RS13480	COG0281	malic enzyme
GPW70_RS13490	COG2949	membrane
GPW70_RS13495	COG3706	GGDEF domain
GPW70_RS13500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW70_RS13510	COG0492	ferredoxin-NADP+ reductase activity
GPW70_RS13515	COG4988	ABC transporter
GPW70_RS13520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPW70_RS13525	COG1187	pseudouridine synthase activity
GPW70_RS13530	COG0009	L-threonylcarbamoyladenylate synthase
GPW70_RS13535	COG0613	PHP domain protein
GPW70_RS13545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW70_RS13550	COG0512	Glutamine amidotransferase of anthranilate synthase
GPW70_RS13555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPW70_RS13560	COG0134	indole-3-glycerol-phosphate synthase activity
GPW70_RS13560	COG0135	phosphoribosylanthranilate isomerase activity
GPW70_RS13565	COG0133	tryptophan synthase activity
GPW70_RS13570	COG0159	tryptophan synthase activity
GPW70_RS13580	COG1435	thymidine kinase activity
GPW70_RS13585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPW70_RS13590	COG1801	Protein of unknown function DUF72
GPW70_RS13595	COG4106	trans-aconitate 2-methyltransferase activity
GPW70_RS13600	COG0500	methyltransferase
GPW70_RS13605	COG4067	protein conserved in archaea
GPW70_RS13605	COG0189	ligase activity
GPW70_RS13620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPW70_RS13630	COG3852	Histidine kinase
GPW70_RS13645	COG3070	regulator of competence-specific genes
GPW70_RS13655	COG2431	L-lysine efflux transmembrane transporter activity
GPW70_RS13665	COG0076	glutamate decarboxylase activity
GPW70_RS13670	COG1737	Transcriptional regulator
GPW70_RS13675	COG1454	alcohol dehydrogenase
GPW70_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
GPW70_RS13680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW70_RS13690	COG0542	response to heat
GPW70_RS13695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPW70_RS13700	COG1278	Cold shock
GPW70_RS13710	COG1187	pseudouridine synthase activity
GPW70_RS13715	COG0140	phosphoribosyl-ATP diphosphatase activity
GPW70_RS13715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPW70_RS13720	COG0107	imidazoleglycerol-phosphate synthase activity
GPW70_RS13725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPW70_RS13730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPW70_RS13735	COG0131	Imidazoleglycerol-phosphate dehydratase
GPW70_RS13735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW70_RS13740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPW70_RS13745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPW70_RS13750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPW70_RS13755	COG1757	Na H antiporter
GPW70_RS13760	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPW70_RS13765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW70_RS13770	COG0482	sulfurtransferase activity
GPW70_RS13775	COG2915	High frequency lysogenization protein hflD homolog
GPW70_RS13780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPW70_RS13790	COG2268	Band 7 protein
GPW70_RS13800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPW70_RS13815	COG0300	oxidoreductase activity
GPW70_RS13825	COG0501	Belongs to the peptidase M48B family
GPW70_RS13835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPW70_RS13840	COG2226	methyltransferase
GPW70_RS13845	COG0156	8-amino-7-oxononanoate synthase activity
GPW70_RS13850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW70_RS13855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPW70_RS13860	COG3385	transposase activity
GPW70_RS13865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPW70_RS13870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPW70_RS13875	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPW70_RS13880	COG0653	protein targeting
GPW70_RS13885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW70_RS13890	COG2199	diguanylate cyclase activity
GPW70_RS13890	COG2203	Gaf domain
GPW70_RS13900	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPW70_RS13910	COG4628	conserved protein (DUF2132)
GPW70_RS13915	COG3092	negative regulation of chromosome organization
GPW70_RS13920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW70_RS13925	COG0857	belongs to the CobB CobQ family
GPW70_RS13925	COG0280	phosphate acetyltransferase
GPW70_RS13930	COG0435	Glutathione S-transferase
GPW70_RS13935	COG4608	Belongs to the ABC transporter superfamily
GPW70_RS13940	COG0444	Belongs to the ABC transporter superfamily
GPW70_RS13945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW70_RS13950	COG0601	transmembrane transport
GPW70_RS13970	COG2204	response regulator
GPW70_RS13975	COG3300	MHYT domain
GPW70_RS13975	COG5001	Diguanylate cyclase
GPW70_RS13980	COG4191	Histidine kinase
GPW70_RS13985	COG5002	protein histidine kinase activity
GPW70_RS13995	COG2201	protein-glutamate methylesterase activity
GPW70_RS14010	COG0009	L-threonylcarbamoyladenylate synthase
GPW70_RS14030	COG1881	PFAM PEBP family protein
GPW70_RS14055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW70_RS14060	COG0640	Transcriptional regulator
GPW70_RS14070	COG3706	GGDEF domain
GPW70_RS14090	COG1946	Acyl-CoA thioesterase
GPW70_RS14095	COG1522	sequence-specific DNA binding
GPW70_RS14105	COG0616	signal peptide processing
GPW70_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
GPW70_RS14125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPW70_RS14130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPW70_RS14140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPW70_RS14145	COG2832	Protein of unknown function (DUF454)
GPW70_RS14155	COG0745	RESPONSE REGULATOR receiver
GPW70_RS14160	COG0583	DNA-binding transcription factor activity
GPW70_RS14165	COG0778	Nitroreductase
GPW70_RS14170	COG1024	Enoyl-CoA hydratase
GPW70_RS14170	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW70_RS14175	COG0183	Belongs to the thiolase family
GPW70_RS14185	COG3385	transposase activity
GPW70_RS14200	COG2067	long-chain fatty acid transport protein
GPW70_RS14210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW70_RS14215	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPW70_RS14220	COG2982	Protein involved in outer membrane biogenesis
GPW70_RS14225	COG0572	uridine kinase
GPW70_RS14230	COG0489	protein tyrosine kinase activity
GPW70_RS14235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW70_RS14235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW70_RS14245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPW70_RS14255	COG4109	DRTGG domain
GPW70_RS14260	COG2199	diguanylate cyclase activity
GPW70_RS14265	COG0314	molybdopterin synthase activity
GPW70_RS14270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPW70_RS14275	COG0315	cyclic pyranopterin monophosphate synthase activity
GPW70_RS14280	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPW70_RS14285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPW70_RS14290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPW70_RS14295	COG2198	Histidine kinase
GPW70_RS14300	COG2204	response regulator
GPW70_RS14305	COG0556	nucleotide-excision repair
GPW70_RS14320	COG4657	Part of a membrane complex involved in electron transport
GPW70_RS14325	COG2878	Part of a membrane complex involved in electron transport
GPW70_RS14330	COG4656	Part of a membrane complex involved in electron transport
GPW70_RS14335	COG4658	electron transport chain
GPW70_RS14340	COG4659	FMN binding
GPW70_RS14345	COG4660	Part of a membrane complex involved in electron transport
GPW70_RS14350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPW70_RS14355	COG0346	lactoylglutathione lyase activity
GPW70_RS14370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW70_RS14375	COG2056	Na+-H+ antiporter family
GPW70_RS14380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPW70_RS14385	COG1286	toxin biosynthetic process
GPW70_RS14390	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPW70_RS14395	COG0285	dihydrofolate synthase activity
GPW70_RS14400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPW70_RS14405	COG0101	tRNA pseudouridine synthase activity
GPW70_RS14415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW70_RS14420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW70_RS14420	COG1263	PTS System
GPW70_RS14420	COG2190	(PTS) system
GPW70_RS14425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW70_RS14430	COG1940	carbohydrate kinase activity
GPW70_RS14430	COG1846	Transcriptional regulator
GPW70_RS14435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW70_RS14435	COG4651	solute:proton antiporter activity
GPW70_RS14440	COG0367	asparagine synthase
GPW70_RS14455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPW70_RS14460	COG0563	adenylate kinase activity
GPW70_RS14465	COG0326	Molecular chaperone. Has ATPase activity
GPW70_RS14470	COG3710	Transcriptional regulator
GPW70_RS14485	COG0622	Phosphoesterase
GPW70_RS14490	COG1090	epimerase
GPW70_RS14495	COG0300	oxidoreductase activity
GPW70_RS14505	COG3118	belongs to the thioredoxin family
GPW70_RS14510	COG0330	HflC and HflK could
GPW70_RS14515	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPW70_RS14520	COG0789	Transcriptional regulator
GPW70_RS14535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPW70_RS14540	COG3115	cell septum assembly
GPW70_RS14545	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPW70_RS14550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPW70_RS14560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW70_RS14570	COG2190	(PTS) system
GPW70_RS14575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW70_RS14580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW70_RS14585	COG1702	phosphate starvation-inducible protein PhoH
GPW70_RS14590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPW70_RS14595	COG4535	Mg2 and Co2 transporter CorC
GPW70_RS14600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPW70_RS14605	COG2888	peptidyl-tyrosine sulfation
GPW70_RS14610	COG0495	leucyl-tRNA aminoacylation
GPW70_RS14615	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPW70_RS14620	COG1466	dna polymerase III delta subunit
GPW70_RS14625	COG0799	negative regulation of ribosome biogenesis
GPW70_RS14630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPW70_RS14635	COG0768	penicillin binding
GPW70_RS14640	COG0772	Belongs to the SEDS family
GPW70_RS14645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW70_RS14650	COG1686	Belongs to the peptidase S11 family
GPW70_RS14655	COG2921	Belongs to the UPF0250 family
GPW70_RS14660	COG0321	lipoyl(octanoyl) transferase activity
GPW70_RS14665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPW70_RS14675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW70_RS14700	COG1596	polysaccharide export
GPW70_RS14710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW70_RS14740	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPW70_RS14750	COG0438	transferase activity, transferring glycosyl groups
GPW70_RS14760	COG1045	serine acetyltransferase
GPW70_RS14785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPW70_RS14790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPW70_RS14795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW70_RS14800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW70_RS14830	COG0366	Alpha amylase catalytic
GPW70_RS14835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW70_RS14835	COG1263	PTS System
GPW70_RS14840	COG1609	Transcriptional regulator
GPW70_RS14845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW70_RS14850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPW70_RS14855	COG2011	ABC-type metal ion transport system permease component
GPW70_RS14860	COG1464	Belongs to the NlpA lipoprotein family
GPW70_RS14865	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPW70_RS14875	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW70_RS14875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW70_RS14885	COG3706	GGDEF domain
GPW70_RS14890	COG1611	Belongs to the LOG family
GPW70_RS14895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW70_RS14900	COG2363	Small membrane protein
GPW70_RS14905	COG0583	DNA-binding transcription factor activity
GPW70_RS14910	COG0301	tRNA thio-modification
GPW70_RS14910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW70_RS14920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPW70_RS14925	COG1722	exodeoxyribonuclease VII activity
GPW70_RS14930	COG0142	geranyltranstransferase activity
GPW70_RS14935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPW70_RS14940	COG0564	pseudouridine synthase activity
GPW70_RS14945	COG3098	single-species biofilm formation
GPW70_RS14960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW70_RS14970	COG1671	Belongs to the UPF0178 family
GPW70_RS14975	COG3385	transposase activity
GPW70_RS14980	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW70_RS14985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPW70_RS14990	COG0254	rRNA binding
GPW70_RS14995	COG1720	tRNA m6t6A37 methyltransferase activity
GPW70_RS15000	COG0442	prolyl-tRNA aminoacylation
GPW70_RS15020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPW70_RS15020	COG0047	phosphoribosylformylglycinamidine synthase activity
GPW70_RS15030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPW70_RS15035	COG0590	tRNA wobble adenosine to inosine editing
GPW70_RS15040	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW70_RS15075	COG0484	heat shock protein binding
GPW70_RS15080	COG0443	Heat shock 70 kDa protein
GPW70_RS15085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPW70_RS15090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPW70_RS15095	COG0497	DNA recombination
GPW70_RS15100	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW70_RS15105	COG2914	Belongs to the UPF0125 (RnfH) family
GPW70_RS15110	COG2867	negative regulation of translational initiation
GPW70_RS15115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPW70_RS15140	COG3064	Membrane
GPW70_RS15150	COG0739	heme binding
GPW70_RS15170	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GPW70_RS15175	COG2207	Transcriptional regulator
GPW70_RS15185	COG1459	type II secretion system
GPW70_RS15190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW70_RS15210	COG4796	Type ii and iii secretion system protein
GPW70_RS15235	COG3710	Transcriptional regulator
GPW70_RS15240	COG0840	transmembrane signaling receptor activity
GPW70_RS15245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GPW70_RS15270	COG1012	belongs to the aldehyde dehydrogenase family
GPW70_RS15285	COG2003	Belongs to the UPF0758 family
GPW70_RS15370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPW70_RS15375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPW70_RS15380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW70_RS15390	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPW70_RS15395	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPW70_RS15400	COG3051	citrate lyase alpha subunit
GPW70_RS15405	COG2301	Belongs to the HpcH HpaI aldolase family
GPW70_RS15410	COG3052	prosthetic group binding
GPW70_RS15415	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPW70_RS15425	COG3630	sodium ion export across plasma membrane
GPW70_RS15430	COG0511	ligase activity, forming carbon-carbon bonds
GPW70_RS15430	COG5016	pyruvate
GPW70_RS15435	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW70_RS15445	COG4565	transcriptional regulatory protein
GPW70_RS15460	COG0583	DNA-binding transcription factor activity
GPW70_RS15465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW70_RS15470	COG1115	amino acid carrier protein
GPW70_RS15475	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPW70_RS15480	COG0583	DNA-binding transcription factor activity
GPW70_RS15490	COG1120	ATPase activity
GPW70_RS15495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW70_RS15500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW70_RS15505	COG4592	Periplasmic binding protein
GPW70_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
GPW70_RS15520	COG1169	isochorismate synthase
GPW70_RS15525	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPW70_RS15530	COG1535	isochorismatase
GPW70_RS15530	COG3433	isochorismatase activity
GPW70_RS15535	COG1584	GPR1 FUN34 yaaH family protein
GPW70_RS15545	COG0519	Catalyzes the synthesis of GMP from XMP
GPW70_RS15545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPW70_RS15550	COG0516	GMP reductase activity
GPW70_RS15550	COG0517	IMP dehydrogenase activity
GPW70_RS15555	COG1570	exodeoxyribonuclease VII activity
GPW70_RS15570	COG1160	GTP binding
GPW70_RS15575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW70_RS15580	COG2976	Protein conserved in bacteria
GPW70_RS15585	COG0124	histidyl-tRNA synthetase
GPW70_RS15590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPW70_RS15605	COG0105	UTP biosynthetic process
GPW70_RS15610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW70_RS15615	COG2975	iron-sulfur cluster assembly
GPW70_RS15620	COG0633	Ferredoxin
GPW70_RS15630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW70_RS15640	COG0822	iron-sulfur transferase activity
GPW70_RS15650	COG1959	2 iron, 2 sulfur cluster binding
GPW70_RS15660	COG0483	inositol monophosphate 1-phosphatase activity
GPW70_RS15665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW70_RS15670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW70_RS15675	COG1862	Preprotein translocase
GPW70_RS15680	COG0343	queuine tRNA-ribosyltransferase activity
GPW70_RS15685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPW70_RS15690	COG0517	IMP dehydrogenase activity
GPW70_RS15700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPW70_RS15705	COG0583	DNA-binding transcription factor activity
GPW70_RS15710	COG0450	alkyl hydroperoxide reductase
GPW70_RS15715	COG3142	Participates in the control of copper homeostasis
GPW70_RS15730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW70_RS15735	COG0581	inorganic phosphate transmembrane transporter activity
GPW70_RS15745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPW70_RS15750	COG0248	Ppx GppA phosphatase
GPW70_RS15760	COG5002	protein histidine kinase activity
GPW70_RS15765	COG0745	RESPONSE REGULATOR receiver
GPW70_RS15770	COG2974	May be involved in recombination
GPW70_RS15780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW70_RS15840	COG0542	response to heat
GPW70_RS15850	COG0564	pseudouridine synthase activity
GPW70_RS15855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW70_RS15860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW70_RS15865	COG0077	Prephenate dehydratase
GPW70_RS15865	COG1605	Chorismate mutase
GPW70_RS15870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW70_RS15875	COG5001	Diguanylate cyclase
GPW70_RS15880	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPW70_RS15885	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPW70_RS15895	COG0488	(ABC) transporter
GPW70_RS15905	COG0287	Prephenate dehydrogenase
GPW70_RS15905	COG1605	Chorismate mutase
GPW70_RS15910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW70_RS15915	COG3275	phosphorelay sensor kinase activity
GPW70_RS15920	COG3279	Response regulator of the LytR AlgR family
GPW70_RS15925	COG1472	Belongs to the glycosyl hydrolase 3 family
GPW70_RS15930	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPW70_RS15935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW70_RS15950	COG1966	Carbon starvation protein
GPW70_RS15955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPW70_RS15960	COG1047	Peptidyl-prolyl cis-trans
GPW70_RS15965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPW70_RS15970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPW70_RS15975	COG0196	riboflavin kinase activity
GPW70_RS15980	COG0728	peptidoglycan biosynthetic process
GPW70_RS15985	COG0268	Binds directly to 16S ribosomal RNA
GPW70_RS15990	COG0640	Transcriptional regulator
GPW70_RS15995	COG0583	DNA-binding transcription factor activity
GPW70_RS16000	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPW70_RS16010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPW70_RS16050	COG3550	peptidyl-serine autophosphorylation
GPW70_RS16100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPW70_RS16105	COG0730	response to heat
GPW70_RS16110	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPW70_RS16115	COG0494	nUDIX hydrolase
GPW70_RS16120	COG3066	DNA modification
GPW70_RS16125	COG0667	Aldo Keto reductase
GPW70_RS16135	COG2204	response regulator
GPW70_RS16140	COG3385	transposase activity
GPW70_RS16145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPW70_RS16160	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPW70_RS16165	COG0513	Belongs to the DEAD box helicase family
GPW70_RS16170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPW70_RS16190	COG3153	acetyltransferase
GPW70_RS16230	COG4785	May be involved in cell division
GPW70_RS16235	COG1185	polyribonucleotide nucleotidyltransferase activity
GPW70_RS16240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPW70_RS16245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPW70_RS16250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPW70_RS16255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPW70_RS16260	COG0195	Participates in both transcription termination and antitermination
GPW70_RS16265	COG0779	Required for maturation of 30S ribosomal subunits
GPW70_RS16280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW70_RS16285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW70_RS16290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPW70_RS16295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPW70_RS16300	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPW70_RS16305	COG1534	Rna-binding protein
GPW70_RS16310	COG3385	transposase activity
GPW70_RS16315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW70_RS16320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW70_RS16325	COG2027	D-alanyl-D-alanine carboxypeptidase
GPW70_RS16330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW70_RS16335	COG0739	heme binding
GPW70_RS16350	COG0316	Belongs to the HesB IscA family
GPW70_RS16355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPW70_RS16365	COG0628	permease
GPW70_RS16370	COG2813	Specifically methylates the guanine in position
GPW70_RS16380	COG0747	negative chemotaxis
GPW70_RS16390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW70_RS16395	COG0444	Belongs to the ABC transporter superfamily
GPW70_RS16400	COG4608	Belongs to the ABC transporter superfamily
GPW70_RS16410	COG2971	BadF BadG BcrA BcrD
GPW70_RS16425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW70_RS16430	COG3842	ATPase activity
GPW70_RS16440	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW70_RS16445	COG0004	ammonium transporteR
GPW70_RS16450	COG0347	Belongs to the P(II) protein family
GPW70_RS16455	COG3112	Uncharacterised protein family (UPF0231)
GPW70_RS16460	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPW70_RS16465	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPW70_RS16470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPW70_RS16475	COG1643	Atp-dependent helicase
GPW70_RS16485	COG1489	DNA binding
GPW70_RS16490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPW70_RS16495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW70_RS16505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW70_RS16510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPW70_RS16515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPW70_RS16520	COG0842	Transport permease protein
GPW70_RS16525	COG1131	(ABC) transporter
GPW70_RS16530	COG0659	secondary active sulfate transmembrane transporter activity
GPW70_RS16535	COG0288	reversible hydration of carbon dioxide
GPW70_RS16550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPW70_RS16555	COG3107	peptidoglycan biosynthetic process
GPW70_RS16560	COG0792	nuclease activity
GPW70_RS16565	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW70_RS16570	COG2823	Periplasmic or secreted lipoprotein
GPW70_RS16575	COG2969	positive regulation of protein catabolic process
GPW70_RS16580	COG0625	glutathione transferase activity
GPW70_RS16585	COG2857	Cytochrome c1
GPW70_RS16590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPW70_RS16595	COG0723	plastoquinol--plastocyanin reductase activity
GPW70_RS16600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPW70_RS16605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPW70_RS16610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPW70_RS16620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW70_RS16625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW70_RS16630	COG0335	large ribosomal subunit rRNA binding
GPW70_RS16635	COG0336	Belongs to the RNA methyltransferase TrmD family
GPW70_RS16640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPW70_RS16645	COG0228	four-way junction DNA binding
GPW70_RS16650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPW70_RS16655	COG4137	Cytochrome C assembly protein
GPW70_RS16660	COG4536	flavin adenine dinucleotide binding
GPW70_RS16665	COG1854	S-ribosylhomocysteine lyase activity
GPW70_RS16670	COG2918	glutathione biosynthetic process
GPW70_RS16675	COG0612	Peptidase, M16
GPW70_RS16680	COG1238	metal cluster binding
GPW70_RS16690	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW70_RS16695	COG5016	pyruvate
GPW70_RS16695	COG0511	ligase activity, forming carbon-carbon bonds
GPW70_RS16700	COG3630	sodium ion export across plasma membrane
GPW70_RS16745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPW70_RS16750	COG0527	aspartate kinase activity
GPW70_RS16755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPW70_RS16760	COG2137	regulation of response to DNA damage stimulus
GPW70_RS16765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPW70_RS16775	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPW70_RS16780	COG4208	sulfate ABC transporter
GPW70_RS16800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPW70_RS16805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW70_RS16810	COG4942	peptidase
GPW70_RS16810	COG1388	LysM domain
GPW70_RS16815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPW70_RS16820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPW70_RS16825	COG0585	pseudouridine synthase activity
GPW70_RS16830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPW70_RS16835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPW70_RS16840	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPW70_RS16845	COG1968	undecaprenyl-diphosphatase activity
GPW70_RS16850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW70_RS16855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPW70_RS16860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPW70_RS16870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPW70_RS16875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPW70_RS16880	COG1610	YqeY-like protein
GPW70_RS16885	COG0358	DNA primase activity
GPW70_RS16890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW70_RS16905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW70_RS16910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPW70_RS16915	COG1349	DNA-binding transcription factor activity
GPW70_RS16920	COG0469	pyruvate kinase activity
GPW70_RS16930	COG0583	DNA-binding transcription factor activity
GPW70_RS16935	COG1279	arginine transmembrane transporter activity
GPW70_RS16940	COG0668	transmembrane transport
GPW70_RS16950	COG0191	fructose-bisphosphate aldolase activity
GPW70_RS16955	COG0126	phosphoglycerate kinase activity
GPW70_RS16960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW70_RS16965	COG4771	TonB-dependent receptor
GPW70_RS16970	COG0583	DNA-binding transcription factor activity
GPW70_RS16975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW70_RS16980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPW70_RS16985	COG3091	SprT-like family
GPW70_RS16990	COG2356	endonuclease I
GPW70_RS16995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPW70_RS17000	COG0189	ligase activity
GPW70_RS17005	COG1678	Uncharacterized ACR, COG1678
GPW70_RS17010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPW70_RS17015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW70_RS17035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPW70_RS17040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPW70_RS17045	COG0762	integral membrane protein
GPW70_RS17060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPW70_RS17065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW70_RS17070	COG2066	Belongs to the glutaminase family
GPW70_RS17075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPW70_RS17080	COG1194	a g-specific adenine glycosylase
GPW70_RS17085	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPW70_RS17090	COG0741	lytic transglycosylase activity
GPW70_RS17115	COG0840	transmembrane signaling receptor activity
GPW70_RS17145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW70_RS17150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPW70_RS17155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW70_RS17160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPW70_RS17165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPW70_RS17170	COG2967	ApaG domain
GPW70_RS17175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPW70_RS17185	COG3610	response to peptide
GPW70_RS17190	COG2966	Psort location CytoplasmicMembrane, score
GPW70_RS17195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPW70_RS17200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPW70_RS17205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPW70_RS17210	COG0142	geranyltranstransferase activity
GPW70_RS17215	COG0531	amino acid
GPW70_RS17220	COG0039	L-malate dehydrogenase activity
GPW70_RS17225	COG1438	arginine binding
GPW70_RS17240	COG0589	response to stress
GPW70_RS17260	COG2235	arginine
GPW70_RS17265	COG0312	modulator of DNA gyrase
GPW70_RS17270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPW70_RS17275	COG3164	Protein of unknown function
GPW70_RS17280	COG1530	ribonuclease E activity
GPW70_RS17285	COG0424	maF-like protein
GPW70_RS17290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPW70_RS17295	COG1792	Involved in formation and maintenance of cell shape
GPW70_RS17300	COG1077	Cell shape determining protein MreB Mrl
GPW70_RS17345	COG1459	type II secretion system
GPW70_RS17350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW70_RS17360	COG3267	Type II secretory pathway component ExeA
GPW70_RS17360	COG3409	Peptidoglycan-binding domain 1 protein
GPW70_RS17385	COG2200	EAL domain
GPW70_RS17385	COG2199	diguanylate cyclase activity
GPW70_RS17390	COG0629	single-stranded DNA binding
GPW70_RS17405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPW70_RS17415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW70_RS17420	COG0527	aspartate kinase activity
GPW70_RS17425	COG0646	methionine synthase
GPW70_RS17425	COG1410	methionine synthase
GPW70_RS17490	COG0175	sulfate reduction
GPW70_RS17495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPW70_RS17500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW70_RS17525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW70_RS17530	COG0735	belongs to the Fur family
GPW70_RS17545	COG0166	Belongs to the GPI family
GPW70_RS17550	COG0432	Pfam Uncharacterised protein family UPF0047
GPW70_RS17555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW70_RS17560	COG0305	Participates in initiation and elongation during chromosome replication
GPW70_RS17570	COG0359	binds to the 23S rRNA
GPW70_RS17575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPW70_RS17580	COG2965	DNA replication, synthesis of RNA primer
GPW70_RS17585	COG0360	Binds together with S18 to 16S ribosomal RNA
GPW70_RS17595	COG2906	2 iron, 2 sulfur cluster binding
GPW70_RS17600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW70_RS17605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW70_RS17610	COG0049	tRNA binding
GPW70_RS17615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPW70_RS17625	COG2923	Belongs to the DsrF TusC family
GPW70_RS17630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPW70_RS17635	COG2964	Protein conserved in bacteria
GPW70_RS17640	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW70_RS17650	COG2900	Belongs to the SlyX family
GPW70_RS17655	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPW70_RS17660	COG0330	HflC and HflK could
GPW70_RS17665	COG0330	HflC and HflK could
GPW70_RS17670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPW70_RS17675	COG1923	regulation of RNA biosynthetic process
GPW70_RS17680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPW70_RS17685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPW70_RS17695	COG0802	atpase or kinase
GPW70_RS17700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPW70_RS17750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPW70_RS17755	COG1162	GTPase activity
GPW70_RS17760	COG0688	phosphatidylethanolamine metabolic process
GPW70_RS17765	COG0471	metal ion transport
GPW70_RS17775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPW70_RS17780	COG4942	peptidase
GPW70_RS17795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPW70_RS17800	COG2816	NAD+ diphosphatase activity
GPW70_RS17805	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPW70_RS17810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPW70_RS17815	COG0085	RNA polymerase activity
GPW70_RS17820	COG0222	ribosome binding
GPW70_RS17825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPW70_RS17830	COG0081	regulation of translation
GPW70_RS17835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPW70_RS17840	COG0250	Participates in transcription elongation, termination and antitermination
GPW70_RS17845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW70_RS17850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW70_RS17875	COG1072	(Pantothenic acid kinase))
GPW70_RS17885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPW70_RS17895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPW70_RS17935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPW70_RS17945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPW70_RS17950	COG3118	belongs to the thioredoxin family
GPW70_RS17955	COG0513	Belongs to the DEAD box helicase family
GPW70_RS17960	COG0248	Ppx GppA phosphatase
GPW70_RS17965	COG2205	protein histidine kinase activity
GPW70_RS17965	COG2202	Pas domain
GPW70_RS17970	COG2814	Major facilitator Superfamily
GPW70_RS17990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW70_RS17995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPW70_RS18000	COG0511	ligase activity, forming carbon-carbon bonds
GPW70_RS18005	COG0439	Biotin carboxylase
GPW70_RS18015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW70_RS18020	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPW70_RS18030	COG1609	Transcriptional regulator
GPW70_RS18035	COG0129	dihydroxy-acid dehydratase activity
GPW70_RS18040	COG3265	gluconokinase activity
GPW70_RS18050	COG0800	Aldolase
GPW70_RS18070	COG0840	transmembrane signaling receptor activity
GPW70_RS18075	COG1982	Orn Lys Arg decarboxylase major
GPW70_RS18080	COG0531	amino acid
GPW70_RS18085	COG3710	Transcriptional regulator
GPW70_RS18090	COG0789	Transcriptional regulator
GPW70_RS18100	COG0138	bifunctional purine biosynthesis protein purh
GPW70_RS18105	COG0151	Belongs to the GarS family
GPW70_RS18110	COG3385	transposase activity
GPW70_RS18120	COG0776	regulation of translation
GPW70_RS18125	COG1253	flavin adenine dinucleotide binding
GPW70_RS18135	COG3068	Protein conserved in bacteria
GPW70_RS18145	COG1573	uracil-dna glycosylase
GPW70_RS18150	COG0668	transmembrane transport
GPW70_RS18160	COG3385	transposase activity
GPW70_RS18170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPW70_RS18195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW70_RS18205	COG0438	transferase activity, transferring glycosyl groups
GPW70_RS18210	COG0438	transferase activity, transferring glycosyl groups
GPW70_RS18225	COG0367	asparagine synthase
GPW70_RS18230	COG1215	transferase activity, transferring glycosyl groups
GPW70_RS18250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW70_RS18255	COG1132	(ABC) transporter
GPW70_RS18265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW70_RS18275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPW70_RS18310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW70_RS18320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW70_RS18345	COG0859	PFAM glycosyl transferase family 9
GPW70_RS18355	COG1519	Transferase
GPW70_RS18385	COG2755	lipolytic protein G-D-S-L family
GPW70_RS18385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GPW70_RS18390	COG3642	lipopolysaccharide core region biosynthetic process
GPW70_RS18395	COG0859	PFAM glycosyl transferase family 9
GPW70_RS18400	COG0463	Glycosyl transferase, family 2
GPW70_RS18405	COG0859	PFAM glycosyl transferase family 9
GPW70_RS18410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPW70_RS18415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPW70_RS18425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPW70_RS18430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPW70_RS18440	COG0840	transmembrane signaling receptor activity
GPW70_RS18445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPW70_RS18455	COG1309	transcriptional regulator
GPW70_RS18460	COG1560	Kdo2-lipid A biosynthetic process
GPW70_RS18465	COG1560	Kdo2-lipid A biosynthetic process
GPW70_RS18470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPW70_RS18475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPW70_RS18480	COG1561	YicC-like family, N-terminal region
GPW70_RS18490	COG1263	PTS System
GPW70_RS18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW70_RS18495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW70_RS18520	COG1120	ATPase activity
GPW70_RS18525	COG4774	siderophore transport
GPW70_RS18530	COG1132	(ABC) transporter
GPW70_RS18545	COG0514	ATP-dependent DNA helicase (RecQ)
GPW70_RS18550	COG2962	Rard protein
GPW70_RS18555	COG0405	Gamma-glutamyltransferase
GPW70_RS18565	COG1280	lysine exporter protein (LysE YggA)
GPW70_RS18570	COG0210	DNA helicase
GPW70_RS18580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPW70_RS18585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW70_RS18595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW70_RS18605	COG0747	negative chemotaxis
GPW70_RS18660	COG1309	transcriptional regulator
GPW70_RS18665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW70_RS18670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW70_RS18675	COG2960	long-chain fatty acid transporting porin activity
GPW70_RS18680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPW70_RS18685	COG0583	DNA-binding transcription factor activity
GPW70_RS18755	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPW70_RS18760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW70_RS18765	COG1739	Uncharacterized protein family UPF0029
GPW70_RS18770	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW70_RS18770	COG1024	Enoyl-CoA hydratase
GPW70_RS18775	COG0183	Belongs to the thiolase family
GPW70_RS18780	COG0583	DNA-binding transcription factor activity
GPW70_RS18785	COG2814	Major facilitator Superfamily
GPW70_RS18795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPW70_RS18800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPW70_RS18805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPW70_RS18810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPW70_RS18815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPW70_RS18820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPW70_RS18830	COG0356	it plays a direct role in the translocation of protons across the membrane
GPW70_RS18835	COG3312	ion transport
GPW70_RS18840	COG1475	DNA binding
GPW70_RS18845	COG1192	Involved in chromosome partitioning
GPW70_RS18850	COG0357	Ribosomal RNA small subunit methyltransferase G
GPW70_RS18855	COG0445	tRNA wobble uridine modification
GPW70_RS18865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW70_RS18870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPW70_RS18875	COG3385	transposase activity
GPW70_RS18880	COG0706	membrane insertase activity
GPW70_RS18885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPW70_RS18890	COG0594	ribonuclease P activity
GPW70_RS18895	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPW70_RS18900	COG1126	abc transporter atp-binding protein
GPW70_RS18915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPW70_RS18920	COG0592	DNA-directed DNA polymerase activity
GPW70_RS18925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPW70_RS18930	COG0187	DNA topoisomerase II activity