locus-tag	class	description
GPW95_RS00005	COG0497	DNA recombination
GPW95_RS00010	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW95_RS00015	COG2914	Belongs to the UPF0125 (RnfH) family
GPW95_RS00020	COG2867	negative regulation of translational initiation
GPW95_RS00025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPW95_RS00060	COG0739	heme binding
GPW95_RS00080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GPW95_RS00085	COG2207	Transcriptional regulator
GPW95_RS00095	COG1459	type II secretion system
GPW95_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW95_RS00145	COG3710	Transcriptional regulator
GPW95_RS00150	COG0840	transmembrane signaling receptor activity
GPW95_RS00155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GPW95_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
GPW95_RS00195	COG2003	Belongs to the UPF0758 family
GPW95_RS00280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPW95_RS00285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPW95_RS00290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW95_RS00300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPW95_RS00305	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPW95_RS00315	COG2301	Belongs to the HpcH HpaI aldolase family
GPW95_RS00320	COG3052	prosthetic group binding
GPW95_RS00325	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPW95_RS00335	COG3630	sodium ion export across plasma membrane
GPW95_RS00340	COG5016	pyruvate
GPW95_RS00340	COG0511	ligase activity, forming carbon-carbon bonds
GPW95_RS00345	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW95_RS00355	COG4565	transcriptional regulatory protein
GPW95_RS00370	COG0583	DNA-binding transcription factor activity
GPW95_RS00375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW95_RS00385	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPW95_RS00390	COG0583	DNA-binding transcription factor activity
GPW95_RS00400	COG1120	ATPase activity
GPW95_RS00405	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW95_RS00410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW95_RS00415	COG4592	Periplasmic binding protein
GPW95_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
GPW95_RS00430	COG1169	isochorismate synthase
GPW95_RS00435	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPW95_RS00440	COG3433	isochorismatase activity
GPW95_RS00440	COG1535	isochorismatase
GPW95_RS00445	COG1584	GPR1 FUN34 yaaH family protein
GPW95_RS00455	COG0519	Catalyzes the synthesis of GMP from XMP
GPW95_RS00455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPW95_RS00460	COG0517	IMP dehydrogenase activity
GPW95_RS00460	COG0516	GMP reductase activity
GPW95_RS00465	COG1570	exodeoxyribonuclease VII activity
GPW95_RS00480	COG1160	GTP binding
GPW95_RS00485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW95_RS00490	COG2976	Protein conserved in bacteria
GPW95_RS00495	COG0124	histidyl-tRNA synthetase
GPW95_RS00500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPW95_RS00515	COG0105	UTP biosynthetic process
GPW95_RS00520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW95_RS00525	COG2975	iron-sulfur cluster assembly
GPW95_RS00530	COG0633	Ferredoxin
GPW95_RS00540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW95_RS00550	COG0822	iron-sulfur transferase activity
GPW95_RS00560	COG1959	2 iron, 2 sulfur cluster binding
GPW95_RS00570	COG0483	inositol monophosphate 1-phosphatase activity
GPW95_RS00575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW95_RS00580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW95_RS00585	COG1862	Preprotein translocase
GPW95_RS00590	COG0343	queuine tRNA-ribosyltransferase activity
GPW95_RS00595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPW95_RS00600	COG0517	IMP dehydrogenase activity
GPW95_RS00610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPW95_RS00615	COG0583	DNA-binding transcription factor activity
GPW95_RS00620	COG0450	alkyl hydroperoxide reductase
GPW95_RS00625	COG3142	Participates in the control of copper homeostasis
GPW95_RS00640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW95_RS00645	COG0581	inorganic phosphate transmembrane transporter activity
GPW95_RS00655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPW95_RS00660	COG0248	Ppx GppA phosphatase
GPW95_RS00670	COG5002	protein histidine kinase activity
GPW95_RS00675	COG0745	RESPONSE REGULATOR receiver
GPW95_RS00680	COG2974	May be involved in recombination
GPW95_RS00690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW95_RS00750	COG0542	response to heat
GPW95_RS00760	COG0564	pseudouridine synthase activity
GPW95_RS00765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW95_RS00770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW95_RS00775	COG1605	Chorismate mutase
GPW95_RS00775	COG0077	Prephenate dehydratase
GPW95_RS00780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW95_RS00785	COG5001	Diguanylate cyclase
GPW95_RS00790	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPW95_RS00795	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPW95_RS00805	COG0488	(ABC) transporter
GPW95_RS00815	COG1605	Chorismate mutase
GPW95_RS00815	COG0287	Prephenate dehydrogenase
GPW95_RS00820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW95_RS00825	COG3275	phosphorelay sensor kinase activity
GPW95_RS00830	COG3279	Response regulator of the LytR AlgR family
GPW95_RS00835	COG1472	Belongs to the glycosyl hydrolase 3 family
GPW95_RS00840	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPW95_RS00845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW95_RS00860	COG1966	Carbon starvation protein
GPW95_RS00865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPW95_RS00870	COG1047	Peptidyl-prolyl cis-trans
GPW95_RS00875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPW95_RS00880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPW95_RS00885	COG0196	riboflavin kinase activity
GPW95_RS00890	COG0728	peptidoglycan biosynthetic process
GPW95_RS00895	COG0268	Binds directly to 16S ribosomal RNA
GPW95_RS00900	COG0640	Transcriptional regulator
GPW95_RS00905	COG0583	DNA-binding transcription factor activity
GPW95_RS00910	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPW95_RS00920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPW95_RS00960	COG3550	peptidyl-serine autophosphorylation
GPW95_RS01010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPW95_RS01015	COG0730	response to heat
GPW95_RS01020	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPW95_RS01025	COG0494	nUDIX hydrolase
GPW95_RS01030	COG3066	DNA modification
GPW95_RS01035	COG0667	Aldo Keto reductase
GPW95_RS01045	COG2204	response regulator
GPW95_RS01050	COG3385	transposase activity
GPW95_RS01055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPW95_RS01070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPW95_RS01075	COG0513	Belongs to the DEAD box helicase family
GPW95_RS01080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPW95_RS01100	COG3153	acetyltransferase
GPW95_RS01140	COG4785	May be involved in cell division
GPW95_RS01145	COG1185	polyribonucleotide nucleotidyltransferase activity
GPW95_RS01150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPW95_RS01155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPW95_RS01160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPW95_RS01165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPW95_RS01170	COG0195	Participates in both transcription termination and antitermination
GPW95_RS01175	COG0779	Required for maturation of 30S ribosomal subunits
GPW95_RS01190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW95_RS01195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW95_RS01200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPW95_RS01205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPW95_RS01210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPW95_RS01215	COG1534	Rna-binding protein
GPW95_RS01220	COG3385	transposase activity
GPW95_RS01225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW95_RS01230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW95_RS01240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW95_RS01245	COG0739	heme binding
GPW95_RS01260	COG0316	Belongs to the HesB IscA family
GPW95_RS01265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPW95_RS01275	COG0628	permease
GPW95_RS01290	COG0747	negative chemotaxis
GPW95_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW95_RS01305	COG0444	Belongs to the ABC transporter superfamily
GPW95_RS01310	COG4608	Belongs to the ABC transporter superfamily
GPW95_RS01320	COG2971	BadF BadG BcrA BcrD
GPW95_RS01335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW95_RS01340	COG3842	ATPase activity
GPW95_RS01350	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW95_RS01355	COG0004	ammonium transporteR
GPW95_RS01360	COG0347	Belongs to the P(II) protein family
GPW95_RS01365	COG3112	Uncharacterised protein family (UPF0231)
GPW95_RS01370	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPW95_RS01375	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPW95_RS01380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPW95_RS01385	COG1643	Atp-dependent helicase
GPW95_RS01395	COG1489	DNA binding
GPW95_RS01400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPW95_RS01405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW95_RS01415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW95_RS01420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPW95_RS01425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPW95_RS01435	COG1131	(ABC) transporter
GPW95_RS01440	COG0659	secondary active sulfate transmembrane transporter activity
GPW95_RS01445	COG0288	reversible hydration of carbon dioxide
GPW95_RS01460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPW95_RS01465	COG3107	peptidoglycan biosynthetic process
GPW95_RS01470	COG0792	nuclease activity
GPW95_RS01475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW95_RS01480	COG2823	Periplasmic or secreted lipoprotein
GPW95_RS01485	COG2969	positive regulation of protein catabolic process
GPW95_RS01490	COG0625	glutathione transferase activity
GPW95_RS01495	COG2857	Cytochrome c1
GPW95_RS01500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPW95_RS01505	COG0723	plastoquinol--plastocyanin reductase activity
GPW95_RS01510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPW95_RS01515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPW95_RS01520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPW95_RS01535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW95_RS01540	COG0335	large ribosomal subunit rRNA binding
GPW95_RS01545	COG0336	Belongs to the RNA methyltransferase TrmD family
GPW95_RS01550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPW95_RS01555	COG0228	four-way junction DNA binding
GPW95_RS01560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPW95_RS01565	COG4137	Cytochrome C assembly protein
GPW95_RS01570	COG4536	flavin adenine dinucleotide binding
GPW95_RS01575	COG1854	S-ribosylhomocysteine lyase activity
GPW95_RS01580	COG2918	glutathione biosynthetic process
GPW95_RS01585	COG0612	Peptidase, M16
GPW95_RS01590	COG1238	metal cluster binding
GPW95_RS01605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW95_RS01610	COG5016	pyruvate
GPW95_RS01610	COG0511	ligase activity, forming carbon-carbon bonds
GPW95_RS01615	COG3630	sodium ion export across plasma membrane
GPW95_RS01660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPW95_RS01665	COG0527	aspartate kinase activity
GPW95_RS01670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPW95_RS01675	COG2137	regulation of response to DNA damage stimulus
GPW95_RS01680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPW95_RS01690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPW95_RS01695	COG4208	sulfate ABC transporter
GPW95_RS01715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPW95_RS01720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW95_RS01725	COG1388	LysM domain
GPW95_RS01725	COG4942	peptidase
GPW95_RS01730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPW95_RS01735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPW95_RS01740	COG0585	pseudouridine synthase activity
GPW95_RS01745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPW95_RS01750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPW95_RS01755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPW95_RS01760	COG1968	undecaprenyl-diphosphatase activity
GPW95_RS01765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW95_RS01770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPW95_RS01775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPW95_RS01790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPW95_RS01795	COG1610	YqeY-like protein
GPW95_RS01800	COG0358	DNA primase activity
GPW95_RS01805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW95_RS01820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW95_RS01825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPW95_RS01830	COG1349	DNA-binding transcription factor activity
GPW95_RS01835	COG0469	pyruvate kinase activity
GPW95_RS01845	COG0583	DNA-binding transcription factor activity
GPW95_RS01850	COG1279	arginine transmembrane transporter activity
GPW95_RS01855	COG0668	transmembrane transport
GPW95_RS01865	COG0191	fructose-bisphosphate aldolase activity
GPW95_RS01870	COG0126	phosphoglycerate kinase activity
GPW95_RS01875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW95_RS01880	COG4771	TonB-dependent receptor
GPW95_RS01885	COG0583	DNA-binding transcription factor activity
GPW95_RS01890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW95_RS01895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPW95_RS01900	COG3091	SprT-like family
GPW95_RS01905	COG2356	endonuclease I
GPW95_RS01910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPW95_RS01915	COG0189	ligase activity
GPW95_RS01920	COG1678	Uncharacterized ACR, COG1678
GPW95_RS01925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPW95_RS01930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW95_RS01950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPW95_RS01955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPW95_RS01960	COG0762	integral membrane protein
GPW95_RS01975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPW95_RS01980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW95_RS01985	COG2066	Belongs to the glutaminase family
GPW95_RS01990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPW95_RS01995	COG1194	a g-specific adenine glycosylase
GPW95_RS02000	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPW95_RS02005	COG0741	lytic transglycosylase activity
GPW95_RS02030	COG0840	transmembrane signaling receptor activity
GPW95_RS02060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW95_RS02065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPW95_RS02070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW95_RS02075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPW95_RS02080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPW95_RS02085	COG2967	ApaG domain
GPW95_RS02090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPW95_RS02100	COG3610	response to peptide
GPW95_RS02105	COG2966	Psort location CytoplasmicMembrane, score
GPW95_RS02110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPW95_RS02115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPW95_RS02120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPW95_RS02125	COG0142	geranyltranstransferase activity
GPW95_RS02130	COG0531	amino acid
GPW95_RS02135	COG0039	L-malate dehydrogenase activity
GPW95_RS02155	COG0589	response to stress
GPW95_RS02175	COG2235	arginine
GPW95_RS02180	COG0312	modulator of DNA gyrase
GPW95_RS02185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPW95_RS02190	COG3164	Protein of unknown function
GPW95_RS02200	COG0424	maF-like protein
GPW95_RS02205	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPW95_RS02210	COG1792	Involved in formation and maintenance of cell shape
GPW95_RS02215	COG1077	Cell shape determining protein MreB Mrl
GPW95_RS02260	COG1459	type II secretion system
GPW95_RS02265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW95_RS02275	COG3267	Type II secretory pathway component ExeA
GPW95_RS02275	COG3409	Peptidoglycan-binding domain 1 protein
GPW95_RS02300	COG2199	diguanylate cyclase activity
GPW95_RS02300	COG2200	EAL domain
GPW95_RS02305	COG0629	single-stranded DNA binding
GPW95_RS02320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPW95_RS02330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW95_RS02335	COG0527	aspartate kinase activity
GPW95_RS02340	COG1410	methionine synthase
GPW95_RS02340	COG0646	methionine synthase
GPW95_RS02405	COG0175	sulfate reduction
GPW95_RS02410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPW95_RS02415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW95_RS02440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW95_RS02445	COG0735	belongs to the Fur family
GPW95_RS02460	COG0166	Belongs to the GPI family
GPW95_RS02465	COG0432	Pfam Uncharacterised protein family UPF0047
GPW95_RS02470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW95_RS02475	COG0305	Participates in initiation and elongation during chromosome replication
GPW95_RS02485	COG0359	binds to the 23S rRNA
GPW95_RS02490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPW95_RS02495	COG2965	DNA replication, synthesis of RNA primer
GPW95_RS02500	COG0360	Binds together with S18 to 16S ribosomal RNA
GPW95_RS02510	COG2906	2 iron, 2 sulfur cluster binding
GPW95_RS02515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW95_RS02520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW95_RS02525	COG0049	tRNA binding
GPW95_RS02530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPW95_RS02540	COG2923	Belongs to the DsrF TusC family
GPW95_RS02545	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPW95_RS02550	COG2964	Protein conserved in bacteria
GPW95_RS02555	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW95_RS02565	COG2900	Belongs to the SlyX family
GPW95_RS02570	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPW95_RS02575	COG0330	HflC and HflK could
GPW95_RS02585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPW95_RS02590	COG1923	regulation of RNA biosynthetic process
GPW95_RS02595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPW95_RS02600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPW95_RS02610	COG0802	atpase or kinase
GPW95_RS02615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPW95_RS02660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPW95_RS02665	COG1162	GTPase activity
GPW95_RS02670	COG0688	phosphatidylethanolamine metabolic process
GPW95_RS02675	COG0471	metal ion transport
GPW95_RS02685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPW95_RS02690	COG4942	peptidase
GPW95_RS02705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPW95_RS02710	COG2816	NAD+ diphosphatase activity
GPW95_RS02715	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPW95_RS02720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPW95_RS02725	COG0085	RNA polymerase activity
GPW95_RS02730	COG0222	ribosome binding
GPW95_RS02735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPW95_RS02740	COG0081	regulation of translation
GPW95_RS02745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPW95_RS02750	COG0250	Participates in transcription elongation, termination and antitermination
GPW95_RS02755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW95_RS02760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW95_RS02785	COG1072	(Pantothenic acid kinase))
GPW95_RS02795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPW95_RS02805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPW95_RS02845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPW95_RS02855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPW95_RS02860	COG3118	belongs to the thioredoxin family
GPW95_RS02865	COG0513	Belongs to the DEAD box helicase family
GPW95_RS02870	COG0248	Ppx GppA phosphatase
GPW95_RS02875	COG2202	Pas domain
GPW95_RS02875	COG2205	protein histidine kinase activity
GPW95_RS02880	COG2814	Major facilitator Superfamily
GPW95_RS02900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW95_RS02905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPW95_RS02910	COG0511	ligase activity, forming carbon-carbon bonds
GPW95_RS02915	COG0439	Biotin carboxylase
GPW95_RS02925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW95_RS02930	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPW95_RS02940	COG1609	Transcriptional regulator
GPW95_RS02945	COG0129	dihydroxy-acid dehydratase activity
GPW95_RS02950	COG3265	gluconokinase activity
GPW95_RS02960	COG0800	Aldolase
GPW95_RS02980	COG0840	transmembrane signaling receptor activity
GPW95_RS02985	COG1982	Orn Lys Arg decarboxylase major
GPW95_RS02990	COG0531	amino acid
GPW95_RS02995	COG3710	Transcriptional regulator
GPW95_RS03000	COG0789	Transcriptional regulator
GPW95_RS03010	COG0138	bifunctional purine biosynthesis protein purh
GPW95_RS03015	COG0151	Belongs to the GarS family
GPW95_RS03020	COG3385	transposase activity
GPW95_RS03030	COG0776	regulation of translation
GPW95_RS03035	COG1253	flavin adenine dinucleotide binding
GPW95_RS03045	COG3068	Protein conserved in bacteria
GPW95_RS03055	COG1573	uracil-dna glycosylase
GPW95_RS03060	COG0668	transmembrane transport
GPW95_RS03070	COG3385	transposase activity
GPW95_RS03080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPW95_RS03085	COG3385	transposase activity
GPW95_RS03105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW95_RS03115	COG0438	transferase activity, transferring glycosyl groups
GPW95_RS03120	COG0438	transferase activity, transferring glycosyl groups
GPW95_RS03135	COG0367	asparagine synthase
GPW95_RS03140	COG1215	transferase activity, transferring glycosyl groups
GPW95_RS03160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW95_RS03165	COG1132	(ABC) transporter
GPW95_RS03175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW95_RS03185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPW95_RS03220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW95_RS03230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW95_RS03255	COG0859	PFAM glycosyl transferase family 9
GPW95_RS03265	COG1519	Transferase
GPW95_RS03300	COG3642	lipopolysaccharide core region biosynthetic process
GPW95_RS03305	COG0859	PFAM glycosyl transferase family 9
GPW95_RS03310	COG0463	Glycosyl transferase, family 2
GPW95_RS03315	COG0859	PFAM glycosyl transferase family 9
GPW95_RS03320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPW95_RS03325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPW95_RS03335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPW95_RS03340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPW95_RS03350	COG0840	transmembrane signaling receptor activity
GPW95_RS03355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPW95_RS03365	COG1309	transcriptional regulator
GPW95_RS03370	COG1560	Kdo2-lipid A biosynthetic process
GPW95_RS03375	COG1560	Kdo2-lipid A biosynthetic process
GPW95_RS03380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPW95_RS03385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPW95_RS03390	COG1561	YicC-like family, N-terminal region
GPW95_RS03400	COG1263	PTS System
GPW95_RS03400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW95_RS03405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW95_RS03430	COG1120	ATPase activity
GPW95_RS03435	COG4774	siderophore transport
GPW95_RS03440	COG1132	(ABC) transporter
GPW95_RS03455	COG0514	ATP-dependent DNA helicase (RecQ)
GPW95_RS03460	COG2962	Rard protein
GPW95_RS03465	COG0405	Gamma-glutamyltransferase
GPW95_RS03475	COG1280	lysine exporter protein (LysE YggA)
GPW95_RS03480	COG0210	DNA helicase
GPW95_RS03490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPW95_RS03495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW95_RS03505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW95_RS03515	COG0747	negative chemotaxis
GPW95_RS03570	COG1309	transcriptional regulator
GPW95_RS03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW95_RS03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW95_RS03585	COG2960	long-chain fatty acid transporting porin activity
GPW95_RS03590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPW95_RS03665	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPW95_RS03670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW95_RS03675	COG1739	Uncharacterized protein family UPF0029
GPW95_RS03680	COG1024	Enoyl-CoA hydratase
GPW95_RS03680	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW95_RS03685	COG0183	Belongs to the thiolase family
GPW95_RS03690	COG0583	DNA-binding transcription factor activity
GPW95_RS03695	COG2814	Major facilitator Superfamily
GPW95_RS03705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPW95_RS03715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPW95_RS03720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPW95_RS03725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPW95_RS03730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPW95_RS03740	COG0356	it plays a direct role in the translocation of protons across the membrane
GPW95_RS03745	COG3312	ion transport
GPW95_RS03750	COG1475	DNA binding
GPW95_RS03755	COG1192	Involved in chromosome partitioning
GPW95_RS03760	COG0357	Ribosomal RNA small subunit methyltransferase G
GPW95_RS03765	COG0445	tRNA wobble uridine modification
GPW95_RS03775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW95_RS03780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPW95_RS03790	COG0706	membrane insertase activity
GPW95_RS03795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPW95_RS03800	COG0594	ribonuclease P activity
GPW95_RS03805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPW95_RS03810	COG1126	abc transporter atp-binding protein
GPW95_RS03825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPW95_RS03830	COG0592	DNA-directed DNA polymerase activity
GPW95_RS03835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPW95_RS03840	COG0187	DNA topoisomerase II activity
GPW95_RS03855	COG0071	Belongs to the small heat shock protein (HSP20) family
GPW95_RS03860	COG3977	Valine--pyruvate aminotransferase
GPW95_RS03865	COG0751	glycine-tRNA ligase activity
GPW95_RS03870	COG0752	glycyl-tRNA synthetase alpha subunit
GPW95_RS03875	COG2119	membrane
GPW95_RS03885	COG0425	Belongs to the sulfur carrier protein TusA family
GPW95_RS03905	COG0129	dihydroxy-acid dehydratase activity
GPW95_RS03910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW95_RS03925	COG0606	chelatase, subunit chli
GPW95_RS03930	COG0204	Acyl-transferase
GPW95_RS03940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW95_RS03945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPW95_RS03955	COG3084	Protein conserved in bacteria
GPW95_RS03960	COG3385	transposase activity
GPW95_RS03985	COG1272	protein, Hemolysin III
GPW95_RS04000	COG0569	domain protein
GPW95_RS04010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW95_RS04015	COG0242	peptide deformylase activity
GPW95_RS04020	COG1652	LysM domain
GPW95_RS04025	COG0758	DNA mediated transformation
GPW95_RS04030	COG2922	Belongs to the Smg family
GPW95_RS04035	COG0551	DNA topoisomerase type I activity
GPW95_RS04040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPW95_RS04045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPW95_RS04050	COG0009	L-threonylcarbamoyladenylate synthase
GPW95_RS04055	COG0408	coproporphyrinogen oxidase activity
GPW95_RS04060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPW95_RS04070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPW95_RS04110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPW95_RS04115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPW95_RS04125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW95_RS04130	COG2104	thiamine diphosphate biosynthetic process
GPW95_RS04135	COG2022	thiamine diphosphate biosynthetic process
GPW95_RS04140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW95_RS04145	COG0006	proline dipeptidase activity
GPW95_RS04165	COG1522	sequence-specific DNA binding
GPW95_RS04170	COG5001	Diguanylate cyclase
GPW95_RS04170	COG5002	protein histidine kinase activity
GPW95_RS04175	COG0742	ribosomal rna small subunit methyltransferase
GPW95_RS04185	COG0697	spore germination
GPW95_RS04190	COG0589	response to stress
GPW95_RS04200	COG1528	Iron-storage protein
GPW95_RS04210	COG2081	HI0933 family
GPW95_RS04220	COG1322	Protein conserved in bacteria
GPW95_RS04225	COG2226	methyltransferase
GPW95_RS04235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPW95_RS04240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW95_RS04245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW95_RS04250	COG0805	protein transport
GPW95_RS04255	COG1858	cytochrome C peroxidase
GPW95_RS04260	COG0534	Mate efflux family protein
GPW95_RS04270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPW95_RS04275	COG2937	Belongs to the GPAT DAPAT family
GPW95_RS04280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPW95_RS04285	COG3161	chorismate lyase activity
GPW95_RS04295	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW95_RS04310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW95_RS04315	COG0084	hydrolase, TatD family'
GPW95_RS04335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW95_RS04335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW95_RS04340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPW95_RS04355	COG3078	GTPase activator activity
GPW95_RS04365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW95_RS04370	COG3071	HemY protein
GPW95_RS04375	COG2959	enzyme of heme biosynthesis
GPW95_RS04380	COG1587	Uroporphyrinogen-III synthase
GPW95_RS04385	COG0181	hydroxymethylbilane synthase activity
GPW95_RS04395	COG3072	Adenylate cyclase
GPW95_RS04400	COG1965	Belongs to the frataxin family
GPW95_RS04410	COG0019	diaminopimelate decarboxylase activity
GPW95_RS04415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPW95_RS04425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPW95_RS04430	COG1011	Hydrolase
GPW95_RS04435	COG3287	FIST C domain
GPW95_RS04435	COG2199	diguanylate cyclase activity
GPW95_RS04435	COG2200	EAL domain
GPW95_RS04450	COG0561	phosphatase activity
GPW95_RS04455	COG2267	carboxylic ester hydrolase activity
GPW95_RS04460	COG1280	lysine exporter protein (LysE YggA)
GPW95_RS04465	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW95_RS04470	COG0783	Belongs to the Dps family
GPW95_RS04500	COG0742	ribosomal rna small subunit methyltransferase
GPW95_RS04505	COG0552	protein localization to endoplasmic reticulum
GPW95_RS04510	COG2884	Cell division ATP-binding protein ftsE
GPW95_RS04515	COG2177	Part of the ABC transporter FtsEX involved in
GPW95_RS04520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW95_RS04525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW95_RS04540	COG3385	transposase activity
GPW95_RS04565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPW95_RS04590	COG2003	Belongs to the UPF0758 family
GPW95_RS04605	COG3339	Conserved Protein
GPW95_RS04660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW95_RS04675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPW95_RS04755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPW95_RS04760	COG5001	Diguanylate cyclase
GPW95_RS04760	COG3300	MHYT domain
GPW95_RS04770	COG3852	Histidine kinase
GPW95_RS04780	COG0174	glutamine synthetase
GPW95_RS04795	COG1660	Displays ATPase and GTPase activities
GPW95_RS04805	COG1490	D-aminoacyl-tRNA deacylase activity
GPW95_RS04820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPW95_RS04825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPW95_RS04830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPW95_RS04835	COG3031	protein transport across the cell outer membrane
GPW95_RS04845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW95_RS04850	COG1459	type II secretion system
GPW95_RS04855	COG2165	general secretion pathway protein
GPW95_RS04860	COG2165	general secretion pathway protein
GPW95_RS04865	COG2165	general secretion pathway protein
GPW95_RS04870	COG4795	General secretion pathway protein
GPW95_RS04875	COG3156	type II secretion system protein K
GPW95_RS04880	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW95_RS04885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW95_RS04895	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPW95_RS04900	COG0494	nUDIX hydrolase
GPW95_RS04905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPW95_RS04905	COG0316	Belongs to the HesB IscA family
GPW95_RS04910	COG1040	competence protein
GPW95_RS04915	COG0596	Alpha beta hydrolase
GPW95_RS04925	COG2183	response to ionizing radiation
GPW95_RS04930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW95_RS04935	COG2199	diguanylate cyclase activity
GPW95_RS04940	COG0745	RESPONSE REGULATOR receiver
GPW95_RS04950	COG2233	PERMEase
GPW95_RS04960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW95_RS04965	COG1758	RNA polymerase activity
GPW95_RS04970	COG0194	GDP metabolic process
GPW95_RS04975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPW95_RS04980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW95_RS04990	COG3263	regulation of cellular component size
GPW95_RS05000	COG4232	protein-disulfide reductase activity
GPW95_RS05015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW95_RS05020	COG1027	Aspartate ammonia-lyase
GPW95_RS05025	COG3706	GGDEF domain
GPW95_RS05030	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPW95_RS05035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPW95_RS05045	COG2205	protein histidine kinase activity
GPW95_RS05050	COG0745	RESPONSE REGULATOR receiver
GPW95_RS05060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPW95_RS05065	COG0205	6-phosphofructokinase activity
GPW95_RS05070	COG1494	fructose-1,6-bisphosphatase
GPW95_RS05075	COG3074	FtsZ-dependent cytokinesis
GPW95_RS05080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPW95_RS05085	COG0460	homoserine dehydrogenase
GPW95_RS05085	COG0527	aspartate kinase activity
GPW95_RS05090	COG0626	cystathionine gamma-synthase activity
GPW95_RS05095	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPW95_RS05100	COG0281	malic enzyme
GPW95_RS05105	COG0254	rRNA binding
GPW95_RS05110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPW95_RS05120	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW95_RS05125	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPW95_RS05130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPW95_RS05135	COG1575	Belongs to the MenA family. Type 1 subfamily
GPW95_RS05140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW95_RS05150	COG0149	triose-phosphate isomerase activity
GPW95_RS05175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW95_RS05180	COG0459	protein refolding
GPW95_RS05190	COG1509	lysine 2,3-aminomutase activity
GPW95_RS05195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW95_RS05200	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW95_RS05205	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW95_RS05210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPW95_RS05215	COG1053	succinate dehydrogenase
GPW95_RS05220	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPW95_RS05225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW95_RS05230	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPW95_RS05235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPW95_RS05240	COG1045	serine acetyltransferase
GPW95_RS05250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPW95_RS05260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPW95_RS05265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW95_RS05270	COG0137	argininosuccinate synthase activity
GPW95_RS05275	COG0165	Argininosuccinate lyase
GPW95_RS05285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW95_RS05290	COG0678	peroxiredoxin activity
GPW95_RS05290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW95_RS05300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPW95_RS05330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPW95_RS05335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPW95_RS05345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPW95_RS05350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPW95_RS05355	COG0546	phosphoglycolate phosphatase activity
GPW95_RS05360	COG0180	Tryptophanyl-tRNA synthetase
GPW95_RS05375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW95_RS05385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPW95_RS05405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW95_RS05410	COG3954	Phosphoribulokinase
GPW95_RS05420	COG0429	hydrolase of the alpha beta-hydrolase fold
GPW95_RS05430	COG0488	(ABC) transporter
GPW95_RS05435	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPW95_RS05450	COG1047	Peptidyl-prolyl cis-trans
GPW95_RS05460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPW95_RS05465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPW95_RS05470	COG3083	sulfuric ester hydrolase activity
GPW95_RS05475	COG0557	exoribonuclease II activity
GPW95_RS05480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW95_RS05485	COG0051	transcription antitermination factor activity, RNA binding
GPW95_RS05490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPW95_RS05495	COG0088	Forms part of the polypeptide exit tunnel
GPW95_RS05500	COG0089	rRNA binding
GPW95_RS05505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPW95_RS05510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPW95_RS05515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPW95_RS05520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPW95_RS05525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPW95_RS05530	COG0255	Belongs to the universal ribosomal protein uL29 family
GPW95_RS05535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPW95_RS05540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPW95_RS05545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPW95_RS05550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPW95_RS05555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPW95_RS05560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPW95_RS05565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPW95_RS05570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPW95_RS05575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPW95_RS05580	COG1841	ribosomal large subunit assembly
GPW95_RS05585	COG0200	Binds to the 23S rRNA
GPW95_RS05590	COG0201	protein transport
GPW95_RS05600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPW95_RS05605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPW95_RS05610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPW95_RS05615	COG0202	RNA polymerase activity
GPW95_RS05620	COG0203	ribosomal protein L17
GPW95_RS05630	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW95_RS05635	COG3266	domain, Protein
GPW95_RS05635	COG3061	Opacity-associated protein A
GPW95_RS05640	COG0697	spore germination
GPW95_RS05645	COG2153	protein acetylation
GPW95_RS05650	COG0513	Belongs to the DEAD box helicase family
GPW95_RS05660	COG0737	Belongs to the 5'-nucleotidase family
GPW95_RS05665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPW95_RS05665	COG1648	precorrin-2 dehydrogenase activity
GPW95_RS05670	COG0175	sulfate reduction
GPW95_RS05675	COG2895	sulfate adenylyltransferase (ATP) activity
GPW95_RS05680	COG0529	Catalyzes the synthesis of activated sulfate
GPW95_RS05700	COG1136	(ABC) transporter
GPW95_RS05715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPW95_RS05720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW95_RS05725	COG0729	surface antigen
GPW95_RS05735	COG2105	PFAM AIG2 family protein
GPW95_RS05740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPW95_RS05745	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPW95_RS05750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW95_RS05755	COG0163	prenyltransferase activity
GPW95_RS05765	COG1178	ABC-type Fe3 transport system permease component
GPW95_RS05770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPW95_RS05775	COG3028	Belongs to the UPF0307 family
GPW95_RS05780	COG0312	modulator of DNA gyrase
GPW95_RS05785	COG2239	Acts as a magnesium transporter
GPW95_RS05790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW95_RS05800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW95_RS05805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW95_RS05815	COG1137	ATPase activity
GPW95_RS05820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPW95_RS05835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPW95_RS05835	COG0517	IMP dehydrogenase activity
GPW95_RS05845	COG1127	ABC transporter
GPW95_RS05850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPW95_RS05855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW95_RS05860	COG2854	intermembrane phospholipid transfer
GPW95_RS05870	COG5007	Belongs to the BolA IbaG family
GPW95_RS05875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPW95_RS05880	COG0204	Acyl-transferase
GPW95_RS05890	COG0251	oxidation-reduction process
GPW95_RS05895	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPW95_RS05900	COG0540	Belongs to the ATCase OTCase family
GPW95_RS05905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPW95_RS05910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPW95_RS05915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPW95_RS05920	COG0564	pseudouridine synthase activity
GPW95_RS05925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW95_RS05930	COG4269	membrane
GPW95_RS05940	COG0525	valine-tRNA ligase activity
GPW95_RS05945	COG2927	DNA polymerase III (CHI subunit)
GPW95_RS05950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW95_RS05955	COG0795	lipopolysaccharide-transporting ATPase activity
GPW95_RS05960	COG0795	lipopolysaccharide-transporting ATPase activity
GPW95_RS05980	COG3437	response regulator, receiver
GPW95_RS06025	COG0066	3-isopropylmalate dehydratase activity
GPW95_RS06030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPW95_RS06035	COG0473	3-isopropylmalate dehydrogenase activity
GPW95_RS06040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW95_RS06060	COG0583	DNA-binding transcription factor activity
GPW95_RS06065	COG1022	Amp-dependent synthetase and ligase
GPW95_RS06070	COG0028	Belongs to the TPP enzyme family
GPW95_RS06075	COG0440	acetolactate synthase activity
GPW95_RS06085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPW95_RS06090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPW95_RS06100	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPW95_RS06110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW95_RS06115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW95_RS06130	COG0354	folic acid binding
GPW95_RS06135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPW95_RS06145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPW95_RS06150	COG1595	DNA-templated transcription, initiation
GPW95_RS06155	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GPW95_RS06160	COG3026	antisigma factor binding
GPW95_RS06165	COG3086	response to oxidative stress
GPW95_RS06170	COG0481	GTPase activity
GPW95_RS06175	COG0681	Belongs to the peptidase S26 family
GPW95_RS06180	COG0571	ribonuclease III activity
GPW95_RS06185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPW95_RS06190	COG1381	Involved in DNA repair and RecF pathway recombination
GPW95_RS06195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPW95_RS06200	COG0736	holo-[acyl-carrier-protein] synthase activity
GPW95_RS06230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW95_RS06235	COG3956	TIGRFAM MazG family protein
GPW95_RS06240	COG0504	CTP synthase activity
GPW95_RS06245	COG0148	phosphopyruvate hydratase activity
GPW95_RS06250	COG0617	tRNA 3'-terminal CCA addition
GPW95_RS06255	COG3267	Type II secretory pathway component ExeA
GPW95_RS06255	COG3409	Peptidoglycan-binding domain 1 protein
GPW95_RS06265	COG4991	sh3 domain protein
GPW95_RS06270	COG0306	phosphate transporter
GPW95_RS06275	COG1392	Phosphate transport regulator
GPW95_RS06280	COG3025	triphosphatase activity
GPW95_RS06290	COG0840	transmembrane signaling receptor activity
GPW95_RS06295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPW95_RS06305	COG1538	Outer membrane efflux protein
GPW95_RS06310	COG0494	nUDIX hydrolase
GPW95_RS06315	COG3151	Protein conserved in bacteria
GPW95_RS06325	COG3150	esterase
GPW95_RS06330	COG0187	DNA topoisomerase II activity
GPW95_RS06335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPW95_RS06340	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPW95_RS06345	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPW95_RS06350	COG0237	dephospho-CoA kinase activity
GPW95_RS06360	COG1459	type II secretion system
GPW95_RS06365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW95_RS06375	COG0157	Belongs to the NadC ModD family
GPW95_RS06390	COG0716	FMN binding
GPW95_RS06395	COG4974	Belongs to the 'phage' integrase family
GPW95_RS06400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW95_RS06405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPW95_RS06410	COG2186	Transcriptional regulator
GPW95_RS06415	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPW95_RS06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW95_RS06425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW95_RS06435	COG0275	rRNA processing
GPW95_RS06440	COG3116	cell division
GPW95_RS06445	COG0768	penicillin binding
GPW95_RS06450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPW95_RS06455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPW95_RS06460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPW95_RS06465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPW95_RS06470	COG0772	Belongs to the SEDS family
GPW95_RS06475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPW95_RS06480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW95_RS06485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPW95_RS06490	COG0849	cell division
GPW95_RS06495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPW95_RS06500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPW95_RS06510	COG0653	protein targeting
GPW95_RS06515	COG0494	nUDIX hydrolase
GPW95_RS06520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPW95_RS06530	COG0505	Belongs to the CarA family
GPW95_RS06535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPW95_RS06555	COG0730	response to heat
GPW95_RS06560	COG0583	DNA-binding transcription factor activity
GPW95_RS06565	COG2860	membrane
GPW95_RS06570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPW95_RS06580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPW95_RS06590	COG0493	'glutamate synthase
GPW95_RS06595	COG0070	glutamate synthase
GPW95_RS06595	COG0069	glutamate synthase activity
GPW95_RS06595	COG0067	glutamate synthase
GPW95_RS06605	COG0067	glutamate synthase
GPW95_RS06605	COG0070	glutamate synthase
GPW95_RS06605	COG0069	glutamate synthase activity
GPW95_RS06610	COG1242	4 iron, 4 sulfur cluster binding
GPW95_RS06620	COG2198	Histidine kinase
GPW95_RS06620	COG0784	Response regulator, receiver
GPW95_RS06620	COG5002	protein histidine kinase activity
GPW95_RS06625	COG0745	RESPONSE REGULATOR receiver
GPW95_RS06635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW95_RS06655	COG0083	homoserine kinase activity
GPW95_RS06660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPW95_RS06665	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPW95_RS06670	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPW95_RS06675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPW95_RS06690	COG1115	amino acid carrier protein
GPW95_RS06705	COG0084	hydrolase, TatD family'
GPW95_RS06710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW95_RS06720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPW95_RS06725	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPW95_RS06730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPW95_RS06750	COG3385	transposase activity
GPW95_RS06760	COG0560	Phosphoserine phosphatase
GPW95_RS06770	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPW95_RS06775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW95_RS06780	COG1022	Amp-dependent synthetase and ligase
GPW95_RS06800	COG1609	Transcriptional regulator
GPW95_RS06805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW95_RS06820	COG0189	ligase activity
GPW95_RS06820	COG0569	domain protein
GPW95_RS06825	COG0456	acetyltransferase
GPW95_RS06835	COG2171	N-acyltransferase activity
GPW95_RS06840	COG3141	response to X-ray
GPW95_RS06855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPW95_RS06860	COG1074	ATP-dependent DNA helicase activity
GPW95_RS06865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPW95_RS06875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPW95_RS06875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW95_RS06885	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPW95_RS06890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPW95_RS06895	COG2166	iron-sulfur cluster assembly
GPW95_RS06900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW95_RS06905	COG0693	protein deglycase activity
GPW95_RS06910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPW95_RS06915	COG3248	Nucleoside-binding outer membrane protein
GPW95_RS06925	COG1595	DNA-templated transcription, initiation
GPW95_RS06935	COG2211	Major facilitator Superfamily
GPW95_RS06940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW95_RS06950	COG2813	Specifically methylates the guanine in position
GPW95_RS06955	COG0271	Belongs to the BolA IbaG family
GPW95_RS06960	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW95_RS06965	COG1805	sodium ion transport
GPW95_RS06970	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW95_RS06975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW95_RS06980	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW95_RS06985	COG2871	sodium ion transport
GPW95_RS06990	COG1477	protein flavinylation
GPW95_RS07000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPW95_RS07010	COG3706	GGDEF domain
GPW95_RS07015	COG0733	neurotransmitter:sodium symporter activity
GPW95_RS07020	COG3385	transposase activity
GPW95_RS07030	COG0189	ligase activity
GPW95_RS07035	COG0189	ligase activity
GPW95_RS07035	COG4067	protein conserved in archaea
GPW95_RS07040	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW95_RS07045	COG2252	PERMEase
GPW95_RS07050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPW95_RS07065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPW95_RS07070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPW95_RS07075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPW95_RS07080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW95_RS07080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW95_RS07095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPW95_RS07100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW95_RS07105	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPW95_RS07110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPW95_RS07120	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPW95_RS07125	COG0024	Methionine aminopeptidase
GPW95_RS07130	COG0052	Belongs to the universal ribosomal protein uS2 family
GPW95_RS07135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPW95_RS07140	COG0528	UMP kinase activity
GPW95_RS07145	COG0233	cytoplasmic translational termination
GPW95_RS07150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPW95_RS07155	COG0575	Belongs to the CDS family
GPW95_RS07160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPW95_RS07165	COG0750	zinc metalloprotease
GPW95_RS07175	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPW95_RS07180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW95_RS07185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW95_RS07190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW95_RS07195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW95_RS07200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPW95_RS07210	COG0825	malonyl-CoA metabolic process
GPW95_RS07220	COG0037	tRNA processing
GPW95_RS07230	COG3479	Phenolic acid decarboxylase
GPW95_RS07235	COG0347	Belongs to the P(II) protein family
GPW95_RS07250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW95_RS07255	COG2226	methyltransferase
GPW95_RS07260	COG0328	RNA-DNA hybrid ribonuclease activity
GPW95_RS07265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW95_RS07275	COG1960	acyl-CoA dehydrogenase activity
GPW95_RS07280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW95_RS07290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPW95_RS07295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPW95_RS07300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPW95_RS07310	COG1187	pseudouridine synthase activity
GPW95_RS07350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW95_RS07365	COG1629	transport
GPW95_RS07365	COG4774	siderophore transport
GPW95_RS07370	COG2375	cellular response to nickel ion
GPW95_RS07375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPW95_RS07375	COG2226	methyltransferase
GPW95_RS07375	COG3433	isochorismatase activity
GPW95_RS07410	COG0784	Response regulator, receiver
GPW95_RS07410	COG0835	chemotaxis
GPW95_RS07415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW95_RS07420	COG1815	bacterial-type flagellum-dependent cell motility
GPW95_RS07425	COG1558	bacterial-type flagellum-dependent cell motility
GPW95_RS07430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPW95_RS07435	COG1749	Flagellar hook protein flgE
GPW95_RS07440	COG4787	bacterial-type flagellum-dependent cell motility
GPW95_RS07445	COG4786	Flagellar basal body rod
GPW95_RS07450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPW95_RS07455	COG1706	bacterial-type flagellum-dependent cell motility
GPW95_RS07460	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPW95_RS07460	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPW95_RS07475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW95_RS07480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW95_RS07565	COG0012	GTP binding
GPW95_RS07570	COG0193	aminoacyl-tRNA hydrolase activity
GPW95_RS07575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPW95_RS07580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPW95_RS07585	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPW95_RS07590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPW95_RS07595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPW95_RS07600	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW95_RS07605	COG3094	Invasion gene expression up-regulator, SirB
GPW95_RS07610	COG2912	Transglutaminase-like superfamily
GPW95_RS07615	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPW95_RS07620	COG0737	Belongs to the 5'-nucleotidase family
GPW95_RS07625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPW95_RS07630	COG2233	PERMEase
GPW95_RS07640	COG3385	transposase activity
GPW95_RS07650	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPW95_RS07655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW95_RS07665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPW95_RS07685	COG4783	chaperone-mediated protein folding
GPW95_RS07690	COG1393	Belongs to the ArsC family
GPW95_RS07705	COG3385	transposase activity
GPW95_RS07710	COG2837	iron assimilation
GPW95_RS07730	COG1393	Belongs to the ArsC family
GPW95_RS07740	COG1876	peptidase activity
GPW95_RS07755	COG3385	transposase activity
GPW95_RS07760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW95_RS07765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW95_RS07770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW95_RS07775	COG1334	flagellar protein FlaG
GPW95_RS07780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPW95_RS07790	COG1516	flagellar protein fliS
GPW95_RS07795	COG2204	response regulator
GPW95_RS07800	COG4191	Histidine kinase
GPW95_RS07810	COG1677	Flagellar hook-basal body complex protein FliE
GPW95_RS07825	COG1317	bacterial-type flagellum organization
GPW95_RS07850	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW95_RS07875	COG1987	bacterial-type flagellum assembly
GPW95_RS07880	COG1684	flagellar biosynthetic protein fliR
GPW95_RS07895	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW95_RS07900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPW95_RS07905	COG2860	membrane
GPW95_RS07910	COG3101	peptidyl-lysine hydroxylation
GPW95_RS07920	COG0431	NADPH-dependent FMN reductase
GPW95_RS07925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPW95_RS07925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW95_RS07930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW95_RS07935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW95_RS07940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW95_RS07945	COG3385	transposase activity
GPW95_RS07950	COG0735	belongs to the Fur family
GPW95_RS07960	COG0583	DNA-binding transcription factor activity
GPW95_RS07965	COG1380	Effector of murein hydrolase LrgA
GPW95_RS07970	COG1346	cytolysis
GPW95_RS07985	COG0596	Alpha beta hydrolase
GPW95_RS07990	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPW95_RS07995	COG0033	Phosphoglucomutase
GPW95_RS08005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPW95_RS08010	COG0372	Belongs to the citrate synthase family
GPW95_RS08015	COG2009	succinate dehydrogenase
GPW95_RS08020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPW95_RS08025	COG1053	succinate dehydrogenase
GPW95_RS08040	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW95_RS08045	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW95_RS08055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPW95_RS08060	COG1121	(ABC) transporter
GPW95_RS08065	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPW95_RS08075	COG1918	ferrous iron import across plasma membrane
GPW95_RS08095	COG0018	arginyl-trna synthetase
GPW95_RS08110	COG2062	phosphohistidine phosphatase, SixA
GPW95_RS08140	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPW95_RS08150	COG2201	protein-glutamate methylesterase activity
GPW95_RS08155	COG1192	Involved in chromosome partitioning
GPW95_RS08165	COG0835	chemotaxis
GPW95_RS08180	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW95_RS08185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW95_RS08195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPW95_RS08200	COG1138	Cytochrome C-type biogenesis protein
GPW95_RS08205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPW95_RS08210	COG4235	cytochrome complex assembly
GPW95_RS08210	COG3088	subunit of a heme lyase
GPW95_RS08220	COG2853	Lipoprotein
GPW95_RS08240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPW95_RS08245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW95_RS08250	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPW95_RS08265	COG3083	sulfuric ester hydrolase activity
GPW95_RS08275	COG3081	Nucleoid-associated protein
GPW95_RS08285	COG1757	Na H antiporter
GPW95_RS08290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW95_RS08295	COG2095	MarC family integral membrane protein
GPW95_RS08300	COG1454	alcohol dehydrogenase
GPW95_RS08300	COG1012	belongs to the aldehyde dehydrogenase family
GPW95_RS08310	COG0659	secondary active sulfate transmembrane transporter activity
GPW95_RS08315	COG1530	ribonuclease E activity
GPW95_RS08320	COG0564	pseudouridine synthase activity
GPW95_RS08325	COG0424	maF-like protein
GPW95_RS08330	COG1399	metal-binding, possibly nucleic acid-binding protein
GPW95_RS08335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPW95_RS08340	COG0416	fatty acid biosynthetic process
GPW95_RS08345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW95_RS08350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPW95_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
GPW95_RS08360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPW95_RS08365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW95_RS08370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW95_RS08375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPW95_RS08380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPW95_RS08390	COG0084	hydrolase, TatD family'
GPW95_RS08395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW95_RS08395	COG1263	PTS System
GPW95_RS08405	COG0733	neurotransmitter:sodium symporter activity
GPW95_RS08420	COG4667	esterase of the alpha-beta hydrolase superfamily
GPW95_RS08430	COG1940	carbohydrate kinase activity
GPW95_RS08435	COG0784	Response regulator, receiver
GPW95_RS08435	COG0835	chemotaxis
GPW95_RS08450	COG2226	methyltransferase
GPW95_RS08460	COG0676	glucose-6-phosphate 1-epimerase activity
GPW95_RS08465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW95_RS08480	COG3139	Protein of unknown function (DUF1315)
GPW95_RS08485	COG0252	asparaginase activity
GPW95_RS08495	COG1902	pentaerythritol trinitrate reductase activity
GPW95_RS08495	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW95_RS08500	COG0788	formyltetrahydrofolate deformylase activity
GPW95_RS08510	COG1199	ATP-dependent helicase activity
GPW95_RS08515	COG1214	PFAM Peptidase M22, glycoprotease
GPW95_RS08530	COG2267	carboxylic ester hydrolase activity
GPW95_RS08535	COG0318	PFAM AMP-dependent synthetase and ligase
GPW95_RS08540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPW95_RS08555	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPW95_RS08560	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPW95_RS08565	COG0436	Aminotransferase
GPW95_RS08570	COG1169	isochorismate synthase
GPW95_RS08575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPW95_RS08580	COG0596	Alpha beta hydrolase
GPW95_RS08590	COG1441	menaquinone biosynthetic process
GPW95_RS08600	COG3135	benzoate transporter
GPW95_RS08625	COG3015	lipoprotein NlpE involved in copper resistance
GPW95_RS08630	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPW95_RS08635	COG2894	cell division
GPW95_RS08640	COG0850	regulation of cytokinetic process
GPW95_RS08645	COG3100	YcgL domain-containing protein
GPW95_RS08660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW95_RS08665	COG3325	Belongs to the glycosyl hydrolase 18 family
GPW95_RS08665	COG3469	chitinase activity
GPW95_RS08670	COG3005	denitrification pathway
GPW95_RS08675	COG0243	molybdopterin cofactor binding
GPW95_RS08695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW95_RS08705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPW95_RS08740	COG4589	Belongs to the CDS family
GPW95_RS08750	COG5001	Diguanylate cyclase
GPW95_RS08750	COG3300	MHYT domain
GPW95_RS08770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW95_RS08775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW95_RS08790	COG4191	Histidine kinase
GPW95_RS08800	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPW95_RS08810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPW95_RS08815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPW95_RS08820	COG0776	regulation of translation
GPW95_RS08825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW95_RS08830	COG1555	photosystem II stabilization
GPW95_RS08835	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPW95_RS08840	COG0539	negative regulation of cytoplasmic translation
GPW95_RS08845	COG0776	regulation of translation
GPW95_RS08850	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPW95_RS08855	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPW95_RS08860	COG0284	orotidine-5'-phosphate decarboxylase activity
GPW95_RS08875	COG0583	DNA-binding transcription factor activity
GPW95_RS08885	COG0686	Belongs to the AlaDH PNT family
GPW95_RS08905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPW95_RS08910	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW95_RS08915	COG2186	Transcriptional regulator
GPW95_RS08960	COG1252	NADH dehydrogenase
GPW95_RS08980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPW95_RS08990	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW95_RS08995	COG1136	(ABC) transporter
GPW95_RS09000	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW95_RS09015	COG2333	competence protein COMEC
GPW95_RS09015	COG0658	competence protein
GPW95_RS09020	COG1132	(ABC) transporter
GPW95_RS09025	COG1663	tetraacyldisaccharide 4'-kinase activity
GPW95_RS09035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPW95_RS09040	COG2719	SpoVR family
GPW95_RS09045	COG2718	Belongs to the UPF0229 family
GPW95_RS09050	COG2766	serine protein kinase
GPW95_RS09055	COG3385	transposase activity
GPW95_RS09060	COG3013	Belongs to the UPF0304 family
GPW95_RS09070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPW95_RS09075	COG0840	transmembrane signaling receptor activity
GPW95_RS09085	COG1882	Formate acetyltransferase
GPW95_RS09105	COG4215	(ABC) transporter
GPW95_RS09110	COG4160	amino acid transport
GPW95_RS09115	COG0708	Exodeoxyribonuclease III
GPW95_RS09125	COG3923	Primosomal replication protein n
GPW95_RS09130	COG0730	response to heat
GPW95_RS09135	COG1199	ATP-dependent helicase activity
GPW95_RS09140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW95_RS09145	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW95_RS09155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW95_RS09160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW95_RS09165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW95_RS09170	COG0215	cysteine-tRNA ligase activity
GPW95_RS09175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPW95_RS09180	COG0632	four-way junction helicase activity
GPW95_RS09185	COG2255	four-way junction helicase activity
GPW95_RS09190	COG1271	oxidase subunit
GPW95_RS09195	COG1294	oxidase, subunit
GPW95_RS09200	COG4890	Cyd operon protein YbgT
GPW95_RS09205	COG3790	cyd operon protein YbgE
GPW95_RS09210	COG0824	Thioesterase
GPW95_RS09215	COG0811	peptide transport
GPW95_RS09230	COG0823	Involved in the tonB-independent uptake of proteins
GPW95_RS09235	COG2885	chlorophyll binding
GPW95_RS09245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPW95_RS09265	COG1482	cell wall glycoprotein biosynthetic process
GPW95_RS09270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW95_RS09270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW95_RS09270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW95_RS09275	COG2207	Transcriptional regulator
GPW95_RS09285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW95_RS09295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW95_RS09310	COG3284	Transcriptional regulator
GPW95_RS09315	COG4628	conserved protein (DUF2132)
GPW95_RS09325	COG0415	Belongs to the DNA photolyase family
GPW95_RS09355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW95_RS09360	COG1940	carbohydrate kinase activity
GPW95_RS09365	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPW95_RS09375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW95_RS09380	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW95_RS09385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW95_RS09390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW95_RS09395	COG1737	Transcriptional regulator
GPW95_RS09400	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW95_RS09405	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW95_RS09415	COG4932	domain protein
GPW95_RS09415	COG5492	domain, Protein
GPW95_RS09450	COG3064	Membrane
GPW95_RS09560	COG4792	protein secretion
GPW95_RS09590	COG3710	Transcriptional regulator
GPW95_RS09600	COG4790	Type iii secretion
GPW95_RS09680	COG0582	viral genome integration into host DNA
GPW95_RS09800	COG0740	serine-type endopeptidase activity
GPW95_RS09815	COG1802	Transcriptional regulator
GPW95_RS09815	COG4626	Terminase
GPW95_RS09850	COG3772	lysozyme
GPW95_RS09875	COG1403	HNH endonuclease
GPW95_RS09980	COG2974	May be involved in recombination
GPW95_RS10000	COG2404	hydrolase activity, acting on ester bonds
GPW95_RS10080	COG0582	viral genome integration into host DNA
GPW95_RS10095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW95_RS10105	COG3008	intermembrane lipid transfer
GPW95_RS10105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW95_RS10110	COG2995	paraquat-inducible protein a
GPW95_RS10115	COG0668	transmembrane transport
GPW95_RS10135	COG1309	transcriptional regulator
GPW95_RS10140	COG1012	belongs to the aldehyde dehydrogenase family
GPW95_RS10160	COG1960	acyl-CoA dehydrogenase activity
GPW95_RS10165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW95_RS10170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPW95_RS10175	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPW95_RS10180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPW95_RS10190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPW95_RS10200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW95_RS10205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW95_RS10210	COG0297	glycogen (starch) synthase activity
GPW95_RS10230	COG3070	regulator of competence-specific genes
GPW95_RS10235	COG1609	Transcriptional regulator
GPW95_RS10245	COG0745	RESPONSE REGULATOR receiver
GPW95_RS10250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW95_RS10255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW95_RS10260	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPW95_RS10265	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPW95_RS10270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPW95_RS10275	COG1979	alcohol dehydrogenase
GPW95_RS10280	COG2207	Transcriptional regulator
GPW95_RS10300	COG1032	radical SAM domain protein
GPW95_RS10325	COG0583	DNA-binding transcription factor activity
GPW95_RS10330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPW95_RS10340	COG2350	Protein conserved in bacteria
GPW95_RS10345	COG1607	acyl-coa hydrolase
GPW95_RS10350	COG2917	probably involved in intracellular septation
GPW95_RS10360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW95_RS10365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW95_RS10375	COG2116	formate transmembrane transporter activity
GPW95_RS10380	COG4459	periplasmic nitrate reductase
GPW95_RS10385	COG3005	denitrification pathway
GPW95_RS10405	COG1227	inorganic diphosphatase activity
GPW95_RS10420	COG4172	Belongs to the ABC transporter superfamily
GPW95_RS10430	COG4171	peptide transport system, permease
GPW95_RS10435	COG4168	peptide transport system, permease
GPW95_RS10445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPW95_RS10450	COG1842	Phage shock protein A
GPW95_RS10465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW95_RS10480	COG2818	Glycosylase
GPW95_RS10485	COG0626	cystathionine gamma-synthase activity
GPW95_RS10500	COG0564	pseudouridine synthase activity
GPW95_RS10505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPW95_RS10510	COG4136	ATPase activity
GPW95_RS10515	COG4135	transport system, permease component
GPW95_RS10520	COG4134	Bacterial extracellular solute-binding protein
GPW95_RS10530	COG3313	Fe-S protein
GPW95_RS10540	COG0842	Transport permease protein
GPW95_RS10545	COG1131	(ABC) transporter
GPW95_RS10550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW95_RS10555	COG0814	amino acid
GPW95_RS10565	COG2239	Acts as a magnesium transporter
GPW95_RS10585	COG4934	collagen metabolic process
GPW95_RS10620	COG0840	transmembrane signaling receptor activity
GPW95_RS10635	COG5001	Diguanylate cyclase
GPW95_RS10635	COG4251	negative regulation of phosphorylation
GPW95_RS10635	COG3706	GGDEF domain
GPW95_RS10635	COG2203	Gaf domain
GPW95_RS10640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPW95_RS10645	COG5002	protein histidine kinase activity
GPW95_RS10670	COG2814	Major facilitator Superfamily
GPW95_RS10680	COG0702	epimerase
GPW95_RS10685	COG0534	Mate efflux family protein
GPW95_RS10690	COG4181	ATPase activity
GPW95_RS10705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW95_RS10715	COG1748	Saccharopine dehydrogenase
GPW95_RS10720	COG0019	diaminopimelate decarboxylase activity
GPW95_RS10730	COG1538	Outer membrane efflux protein
GPW95_RS10740	COG3385	transposase activity
GPW95_RS10750	COG1538	Outer membrane efflux protein
GPW95_RS10755	COG1566	PFAM secretion protein HlyD family protein
GPW95_RS10760	COG2814	Major facilitator Superfamily
GPW95_RS10765	COG0840	transmembrane signaling receptor activity
GPW95_RS10770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPW95_RS10780	COG3501	Rhs element vgr protein
GPW95_RS10800	COG1280	lysine exporter protein (LysE YggA)
GPW95_RS10805	COG1115	amino acid carrier protein
GPW95_RS10820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW95_RS10825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW95_RS10830	COG1177	transmembrane transport
GPW95_RS10835	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPW95_RS10840	COG3842	ATPase activity
GPW95_RS10860	COG0037	tRNA processing
GPW95_RS10865	COG0589	response to stress
GPW95_RS10870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW95_RS10885	COG2217	Heavy metal translocating P-type atpase
GPW95_RS10895	COG2010	Cytochrome c
GPW95_RS10925	COG0784	Response regulator, receiver
GPW95_RS10925	COG2205	protein histidine kinase activity
GPW95_RS10950	COG2994	toxin metabolic process
GPW95_RS10960	COG3064	Membrane
GPW95_RS10960	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPW95_RS10960	COG1073	alpha beta
GPW95_RS11025	COG4128	Pfam Zonular occludens toxin
GPW95_RS11070	COG4128	Pfam Zonular occludens toxin
GPW95_RS11115	COG3120	sequence-specific DNA binding
GPW95_RS11120	COG1067	ATP-dependent peptidase activity
GPW95_RS11125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW95_RS11150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW95_RS11150	COG0116	Belongs to the methyltransferase superfamily
GPW95_RS11160	COG0167	dihydroorotate dehydrogenase activity
GPW95_RS11175	COG0308	aminopeptidase N
GPW95_RS11190	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPW95_RS11195	COG1956	GAF domain-containing protein
GPW95_RS11200	COG1132	(ABC) transporter
GPW95_RS11205	COG2995	paraquat-inducible protein a
GPW95_RS11210	COG3008	intermembrane lipid transfer
GPW95_RS11215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW95_RS11215	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPW95_RS11220	COG2996	Protein conserved in bacteria
GPW95_RS11235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW95_RS11245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPW95_RS11260	COG0437	4 iron, 4 sulfur cluster binding
GPW95_RS11265	COG0243	molybdopterin cofactor binding
GPW95_RS11265	COG3383	formate dehydrogenase (NAD+) activity
GPW95_RS11295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPW95_RS11300	COG0488	(ABC) transporter
GPW95_RS11305	COG3852	Histidine kinase
GPW95_RS11310	COG2204	response regulator
GPW95_RS11320	COG4662	Binding-protein-dependent transport system inner membrane component
GPW95_RS11325	COG3842	ATPase activity
GPW95_RS11330	COG0746	molybdenum cofactor guanylyltransferase activity
GPW95_RS11345	COG1940	carbohydrate kinase activity
GPW95_RS11360	COG0840	transmembrane signaling receptor activity
GPW95_RS11365	COG0791	NLP P60 protein
GPW95_RS11385	COG0534	Mate efflux family protein
GPW95_RS11395	COG1793	dna ligase
GPW95_RS11405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW95_RS11410	COG0848	biopolymer transport protein
GPW95_RS11415	COG0811	peptide transport
GPW95_RS11420	COG0811	peptide transport
GPW95_RS11435	COG1175	transmembrane transport
GPW95_RS11440	COG0395	ABC-type sugar transport system, permease component
GPW95_RS11445	COG3842	ATPase activity
GPW95_RS11450	COG1349	DNA-binding transcription factor activity
GPW95_RS11455	COG0584	glycerophosphoryl diester phosphodiesterase
GPW95_RS11460	COG2731	YhcH YjgK YiaL family protein
GPW95_RS11465	COG0251	oxidation-reduction process
GPW95_RS11470	COG1609	Transcriptional regulator
GPW95_RS11475	COG2723	6-phospho-beta-galactosidase activity
GPW95_RS11480	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPW95_RS11510	COG0577	efflux transmembrane transporter activity
GPW95_RS11510	COG1136	(ABC) transporter
GPW95_RS11515	COG1136	(ABC) transporter
GPW95_RS11515	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW95_RS11520	COG1294	oxidase, subunit
GPW95_RS11525	COG1271	oxidase subunit
GPW95_RS11590	COG3527	Alpha-acetolactate decarboxylase
GPW95_RS11605	COG2200	EAL domain
GPW95_RS11605	COG2199	diguanylate cyclase activity
GPW95_RS11610	COG3706	GGDEF domain
GPW95_RS11615	COG2017	converts alpha-aldose to the beta-anomer
GPW95_RS11620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPW95_RS11625	COG1085	galactose-1-phosphate uridylyltransferase
GPW95_RS11650	COG0745	RESPONSE REGULATOR receiver
GPW95_RS11650	COG3706	GGDEF domain
GPW95_RS11670	COG0835	chemotaxis
GPW95_RS11670	COG0784	Response regulator, receiver
GPW95_RS11680	COG4565	transcriptional regulatory protein
GPW95_RS11685	COG3290	protein histidine kinase activity
GPW95_RS11700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW95_RS11720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPW95_RS11725	COG3063	Type IV pilus biogenesis stability protein PilW
GPW95_RS11740	COG1451	nucleotide metabolic process
GPW95_RS11750	COG0583	DNA-binding transcription factor activity
GPW95_RS11770	COG0513	Belongs to the DEAD box helicase family
GPW95_RS11780	COG0840	transmembrane signaling receptor activity
GPW95_RS11790	COG0835	chemotaxis
GPW95_RS11795	COG2201	protein-glutamate methylesterase activity
GPW95_RS11805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW95_RS11815	COG2198	Histidine kinase
GPW95_RS11815	COG0643	Histidine kinase
GPW95_RS11835	COG2076	Multidrug Resistance protein
GPW95_RS11840	COG0415	Belongs to the DNA photolyase family
GPW95_RS11845	COG0477	Major facilitator Superfamily
GPW95_RS11850	COG0583	DNA-binding transcription factor activity
GPW95_RS11860	COG0402	S-adenosylhomocysteine deaminase activity
GPW95_RS11865	COG0095	Lipoate-protein ligase
GPW95_RS11870	COG0443	Heat shock 70 kDa protein
GPW95_RS11885	COG1643	Atp-dependent helicase
GPW95_RS11920	COG0443	Heat shock 70 kDa protein
GPW95_RS11925	COG0443	Heat shock 70 kDa protein
GPW95_RS11930	COG3706	GGDEF domain
GPW95_RS11960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPW95_RS11965	COG0602	queuosine metabolic process
GPW95_RS11970	COG0561	phosphatase activity
GPW95_RS11980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW95_RS11985	COG4597	amino acid ABC transporter
GPW95_RS11995	COG1126	abc transporter atp-binding protein
GPW95_RS12000	COG0670	Belongs to the BI1 family
GPW95_RS12005	COG2920	part of a sulfur-relay system
GPW95_RS12010	COG1254	Belongs to the acylphosphatase family
GPW95_RS12030	COG3850	Histidine kinase
GPW95_RS12030	COG2205	protein histidine kinase activity
GPW95_RS12030	COG3437	response regulator, receiver
GPW95_RS12030	COG4999	Histidine kinase
GPW95_RS12035	COG3437	response regulator, receiver
GPW95_RS12040	COG0625	glutathione transferase activity
GPW95_RS12050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPW95_RS12060	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW95_RS12090	COG0372	Belongs to the citrate synthase family
GPW95_RS12095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPW95_RS12100	COG2186	Transcriptional regulator
GPW95_RS12135	COG1129	ABC transporter
GPW95_RS12160	COG0745	RESPONSE REGULATOR receiver
GPW95_RS12165	COG5002	protein histidine kinase activity
GPW95_RS12170	COG3713	MltA-interacting MipA family protein
GPW95_RS12175	COG2990	Protein conserved in bacteria
GPW95_RS12185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW95_RS12185	COG4191	Histidine kinase
GPW95_RS12190	COG0471	metal ion transport
GPW95_RS12200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW95_RS12220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW95_RS12225	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPW95_RS12230	COG3768	UPF0283 membrane protein
GPW95_RS12235	COG3106	COG3106 Predicted ATPase
GPW95_RS12250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW95_RS12255	COG0494	nUDIX hydrolase
GPW95_RS12260	COG0814	amino acid
GPW95_RS12265	COG1760	l-serine dehydratase
GPW95_RS12270	COG0720	synthase
GPW95_RS12280	COG0017	Asparaginyl-tRNA synthetase
GPW95_RS12285	COG3385	transposase activity
GPW95_RS12290	COG0352	thiamine-phosphate diphosphorylase activity
GPW95_RS12290	COG0351	phosphomethylpyrimidine kinase
GPW95_RS12295	COG3437	response regulator, receiver
GPW95_RS12295	COG2770	Histidine kinase
GPW95_RS12305	COG1448	Aminotransferase
GPW95_RS12325	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPW95_RS12335	COG1609	Transcriptional regulator
GPW95_RS12340	COG3394	polysaccharide catabolic process
GPW95_RS12350	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPW95_RS12360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPW95_RS12365	COG0726	polysaccharide deacetylase
GPW95_RS12370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPW95_RS12375	COG1846	Transcriptional regulator
GPW95_RS12400	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW95_RS12415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW95_RS12420	COG3108	Peptidase M15
GPW95_RS12450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW95_RS12460	COG2814	Major facilitator Superfamily
GPW95_RS12480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW95_RS12485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW95_RS12490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW95_RS12520	COG0840	transmembrane signaling receptor activity
GPW95_RS12535	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPW95_RS12545	COG2988	succinylglutamate desuccinylase activity
GPW95_RS12560	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPW95_RS12565	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPW95_RS12570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW95_RS12580	COG2925	Exonuclease
GPW95_RS12590	COG1346	cytolysis
GPW95_RS12595	COG0295	cytidine deaminase activity
GPW95_RS12615	COG0500	methyltransferase
GPW95_RS12630	COG0776	regulation of translation
GPW95_RS12635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW95_RS12635	COG0072	phenylalanine-tRNA ligase activity
GPW95_RS12640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPW95_RS12650	COG3706	GGDEF domain
GPW95_RS12650	COG0745	RESPONSE REGULATOR receiver
GPW95_RS12680	COG0322	excinuclease ABC activity
GPW95_RS12685	COG2197	response regulator
GPW95_RS12690	COG0417	DNA replication proofreading
GPW95_RS12695	COG5001	Diguanylate cyclase
GPW95_RS12705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW95_RS12725	COG1228	amidohydrolase
GPW95_RS12730	COG0010	Belongs to the arginase family
GPW95_RS12735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPW95_RS12740	COG2986	histidine ammonia-lyase
GPW95_RS12760	COG0247	lactate metabolic process
GPW95_RS12760	COG0277	FAD linked oxidase domain protein
GPW95_RS12775	COG2885	chlorophyll binding
GPW95_RS12795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPW95_RS12805	COG0281	malic enzyme
GPW95_RS12815	COG2949	membrane
GPW95_RS12820	COG3706	GGDEF domain
GPW95_RS12825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW95_RS12835	COG0492	ferredoxin-NADP+ reductase activity
GPW95_RS12840	COG4988	ABC transporter
GPW95_RS12845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPW95_RS12850	COG1187	pseudouridine synthase activity
GPW95_RS12855	COG0009	L-threonylcarbamoyladenylate synthase
GPW95_RS12860	COG0613	PHP domain protein
GPW95_RS12870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW95_RS12875	COG0512	Glutamine amidotransferase of anthranilate synthase
GPW95_RS12880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPW95_RS12885	COG0134	indole-3-glycerol-phosphate synthase activity
GPW95_RS12885	COG0135	phosphoribosylanthranilate isomerase activity
GPW95_RS12890	COG0133	tryptophan synthase activity
GPW95_RS12895	COG0159	tryptophan synthase activity
GPW95_RS12905	COG1435	thymidine kinase activity
GPW95_RS12910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPW95_RS12915	COG1801	Protein of unknown function DUF72
GPW95_RS12920	COG4106	trans-aconitate 2-methyltransferase activity
GPW95_RS12925	COG0500	methyltransferase
GPW95_RS12930	COG4067	protein conserved in archaea
GPW95_RS12930	COG0189	ligase activity
GPW95_RS12955	COG3852	Histidine kinase
GPW95_RS12970	COG3070	regulator of competence-specific genes
GPW95_RS12980	COG2431	L-lysine efflux transmembrane transporter activity
GPW95_RS12990	COG0076	glutamate decarboxylase activity
GPW95_RS12995	COG1737	Transcriptional regulator
GPW95_RS13000	COG1454	alcohol dehydrogenase
GPW95_RS13000	COG1012	belongs to the aldehyde dehydrogenase family
GPW95_RS13005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW95_RS13015	COG0542	response to heat
GPW95_RS13020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPW95_RS13025	COG1278	Cold shock
GPW95_RS13035	COG1187	pseudouridine synthase activity
GPW95_RS13040	COG0140	phosphoribosyl-ATP diphosphatase activity
GPW95_RS13040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPW95_RS13045	COG0107	imidazoleglycerol-phosphate synthase activity
GPW95_RS13050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPW95_RS13055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPW95_RS13060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW95_RS13060	COG0131	Imidazoleglycerol-phosphate dehydratase
GPW95_RS13065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPW95_RS13070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPW95_RS13075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPW95_RS13080	COG1757	Na H antiporter
GPW95_RS13085	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPW95_RS13090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW95_RS13095	COG0482	sulfurtransferase activity
GPW95_RS13100	COG2915	High frequency lysogenization protein hflD homolog
GPW95_RS13105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPW95_RS13115	COG2268	Band 7 protein
GPW95_RS13125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPW95_RS13140	COG0300	oxidoreductase activity
GPW95_RS13160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPW95_RS13165	COG2226	methyltransferase
GPW95_RS13170	COG0156	8-amino-7-oxononanoate synthase activity
GPW95_RS13180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPW95_RS13190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPW95_RS13195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPW95_RS13200	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPW95_RS13205	COG0653	protein targeting
GPW95_RS13210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW95_RS13215	COG2203	Gaf domain
GPW95_RS13215	COG2199	diguanylate cyclase activity
GPW95_RS13225	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPW95_RS13235	COG4628	conserved protein (DUF2132)
GPW95_RS13240	COG3092	negative regulation of chromosome organization
GPW95_RS13245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW95_RS13250	COG0857	belongs to the CobB CobQ family
GPW95_RS13250	COG0280	phosphate acetyltransferase
GPW95_RS13255	COG0435	Glutathione S-transferase
GPW95_RS13260	COG4608	Belongs to the ABC transporter superfamily
GPW95_RS13265	COG0444	Belongs to the ABC transporter superfamily
GPW95_RS13270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW95_RS13275	COG0601	transmembrane transport
GPW95_RS13295	COG2204	response regulator
GPW95_RS13300	COG3300	MHYT domain
GPW95_RS13300	COG5001	Diguanylate cyclase
GPW95_RS13305	COG4191	Histidine kinase
GPW95_RS13310	COG5002	protein histidine kinase activity
GPW95_RS13320	COG2201	protein-glutamate methylesterase activity
GPW95_RS13335	COG0009	L-threonylcarbamoyladenylate synthase
GPW95_RS13355	COG1881	PFAM PEBP family protein
GPW95_RS13380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW95_RS13385	COG0640	Transcriptional regulator
GPW95_RS13395	COG3706	GGDEF domain
GPW95_RS13415	COG1946	Acyl-CoA thioesterase
GPW95_RS13420	COG1522	sequence-specific DNA binding
GPW95_RS13430	COG0616	signal peptide processing
GPW95_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
GPW95_RS13450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPW95_RS13455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPW95_RS13465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPW95_RS13470	COG2832	Protein of unknown function (DUF454)
GPW95_RS13480	COG0745	RESPONSE REGULATOR receiver
GPW95_RS13485	COG0583	DNA-binding transcription factor activity
GPW95_RS13490	COG0778	Nitroreductase
GPW95_RS13495	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW95_RS13495	COG1024	Enoyl-CoA hydratase
GPW95_RS13500	COG0183	Belongs to the thiolase family
GPW95_RS13515	COG2067	long-chain fatty acid transport protein
GPW95_RS13525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW95_RS13530	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPW95_RS13535	COG2982	Protein involved in outer membrane biogenesis
GPW95_RS13540	COG0572	uridine kinase
GPW95_RS13545	COG0489	protein tyrosine kinase activity
GPW95_RS13550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW95_RS13550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW95_RS13560	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPW95_RS13570	COG4109	DRTGG domain
GPW95_RS13575	COG2199	diguanylate cyclase activity
GPW95_RS13580	COG0314	molybdopterin synthase activity
GPW95_RS13585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPW95_RS13590	COG0315	cyclic pyranopterin monophosphate synthase activity
GPW95_RS13595	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPW95_RS13600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPW95_RS13605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPW95_RS13610	COG2198	Histidine kinase
GPW95_RS13615	COG2204	response regulator
GPW95_RS13635	COG4657	Part of a membrane complex involved in electron transport
GPW95_RS13640	COG2878	Part of a membrane complex involved in electron transport
GPW95_RS13645	COG4656	Part of a membrane complex involved in electron transport
GPW95_RS13650	COG4658	electron transport chain
GPW95_RS13655	COG4659	FMN binding
GPW95_RS13660	COG4660	Part of a membrane complex involved in electron transport
GPW95_RS13665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPW95_RS13670	COG0346	lactoylglutathione lyase activity
GPW95_RS13685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW95_RS13690	COG2056	Na+-H+ antiporter family
GPW95_RS13695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPW95_RS13700	COG1286	toxin biosynthetic process
GPW95_RS13705	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPW95_RS13710	COG0285	dihydrofolate synthase activity
GPW95_RS13715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPW95_RS13720	COG0101	tRNA pseudouridine synthase activity
GPW95_RS13730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW95_RS13735	COG2190	(PTS) system
GPW95_RS13735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW95_RS13735	COG1263	PTS System
GPW95_RS13740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW95_RS13750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW95_RS13750	COG4651	solute:proton antiporter activity
GPW95_RS13770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPW95_RS13775	COG0563	adenylate kinase activity
GPW95_RS13780	COG0326	Molecular chaperone. Has ATPase activity
GPW95_RS13785	COG3710	Transcriptional regulator
GPW95_RS13800	COG0622	Phosphoesterase
GPW95_RS13805	COG1090	epimerase
GPW95_RS13810	COG0300	oxidoreductase activity
GPW95_RS13820	COG3118	belongs to the thioredoxin family
GPW95_RS13825	COG0330	HflC and HflK could
GPW95_RS13830	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPW95_RS13835	COG0789	Transcriptional regulator
GPW95_RS13850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPW95_RS13855	COG3115	cell septum assembly
GPW95_RS13860	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPW95_RS13865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPW95_RS13875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW95_RS13885	COG2190	(PTS) system
GPW95_RS13890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW95_RS13895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW95_RS13900	COG1702	phosphate starvation-inducible protein PhoH
GPW95_RS13905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPW95_RS13910	COG4535	Mg2 and Co2 transporter CorC
GPW95_RS13920	COG2888	peptidyl-tyrosine sulfation
GPW95_RS13925	COG0495	leucyl-tRNA aminoacylation
GPW95_RS13930	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPW95_RS13935	COG1466	dna polymerase III delta subunit
GPW95_RS13940	COG0799	negative regulation of ribosome biogenesis
GPW95_RS13945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPW95_RS13950	COG0768	penicillin binding
GPW95_RS13955	COG0772	Belongs to the SEDS family
GPW95_RS13965	COG1686	Belongs to the peptidase S11 family
GPW95_RS13970	COG2921	Belongs to the UPF0250 family
GPW95_RS13975	COG0321	lipoyl(octanoyl) transferase activity
GPW95_RS13980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPW95_RS13990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW95_RS14015	COG1596	polysaccharide export
GPW95_RS14025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW95_RS14055	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPW95_RS14065	COG0438	transferase activity, transferring glycosyl groups
GPW95_RS14075	COG1045	serine acetyltransferase
GPW95_RS14100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPW95_RS14105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPW95_RS14110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW95_RS14115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW95_RS14145	COG0366	Alpha amylase catalytic
GPW95_RS14150	COG1263	PTS System
GPW95_RS14150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW95_RS14155	COG1609	Transcriptional regulator
GPW95_RS14160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW95_RS14165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPW95_RS14170	COG2011	ABC-type metal ion transport system permease component
GPW95_RS14175	COG1464	Belongs to the NlpA lipoprotein family
GPW95_RS14180	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPW95_RS14190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW95_RS14190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW95_RS14200	COG3706	GGDEF domain
GPW95_RS14210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW95_RS14215	COG2363	Small membrane protein
GPW95_RS14220	COG0583	DNA-binding transcription factor activity
GPW95_RS14225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW95_RS14225	COG0301	tRNA thio-modification
GPW95_RS14235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPW95_RS14240	COG1722	exodeoxyribonuclease VII activity
GPW95_RS14245	COG0142	geranyltranstransferase activity
GPW95_RS14255	COG0564	pseudouridine synthase activity
GPW95_RS14260	COG3098	single-species biofilm formation
GPW95_RS14275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW95_RS14285	COG1671	Belongs to the UPF0178 family
GPW95_RS14290	COG3385	transposase activity
GPW95_RS14295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW95_RS14300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPW95_RS14305	COG0254	rRNA binding
GPW95_RS14310	COG1720	tRNA m6t6A37 methyltransferase activity
GPW95_RS14315	COG0442	prolyl-tRNA aminoacylation
GPW95_RS14340	COG0047	phosphoribosylformylglycinamidine synthase activity
GPW95_RS14340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPW95_RS14350	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPW95_RS14355	COG0590	tRNA wobble adenosine to inosine editing
GPW95_RS14360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW95_RS14395	COG0484	heat shock protein binding
GPW95_RS14400	COG0443	Heat shock 70 kDa protein
GPW95_RS14405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPW95_RS14410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPW95_RS14425	COG3501	Rhs element vgr protein
GPW95_RS14435	COG3385	transposase activity
GPW95_RS14440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPW95_RS14445	COG1640	4-alpha-glucanotransferase
GPW95_RS14450	COG0058	SHG alpha-glucan phosphorylase activity
GPW95_RS14455	COG2909	trisaccharide binding
GPW95_RS14475	COG2084	Dehydrogenase
GPW95_RS14480	COG0217	transcriptional regulatory protein
GPW95_RS14520	COG1444	tRNA N-acetyltransferase activity
GPW95_RS14550	COG0745	RESPONSE REGULATOR receiver
GPW95_RS14555	COG0642	Histidine kinase
GPW95_RS14560	COG2194	sulfuric ester hydrolase activity
GPW95_RS14570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW95_RS14575	COG0601	transmembrane transport
GPW95_RS14595	COG0643	Histidine kinase
GPW95_RS14595	COG2198	Histidine kinase
GPW95_RS14600	COG0835	chemotaxis
GPW95_RS14605	COG0835	chemotaxis
GPW95_RS14610	COG0840	transmembrane signaling receptor activity
GPW95_RS14615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW95_RS14620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPW95_RS14640	COG0745	RESPONSE REGULATOR receiver
GPW95_RS14670	COG0259	pyridoxamine-phosphate oxidase activity
GPW95_RS14680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPW95_RS14705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW95_RS14740	COG2409	Drug exporters of the RND superfamily
GPW95_RS14745	COG2197	response regulator
GPW95_RS14755	COG1982	Orn Lys Arg decarboxylase major
GPW95_RS14760	COG0531	amino acid
GPW95_RS14770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW95_RS14775	COG1901	pseudouridine methyltransferase
GPW95_RS14785	COG4221	oxidoreductase activity
GPW95_RS14790	COG0840	transmembrane signaling receptor activity
GPW95_RS14800	COG2910	NAD(P)H-binding
GPW95_RS14830	COG0673	inositol 2-dehydrogenase activity
GPW95_RS14835	COG3722	fumarate hydratase activity
GPW95_RS14840	COG0246	Mannitol dehydrogenase
GPW95_RS14845	COG2213	PTS system mannitol-specific
GPW95_RS14845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW95_RS14865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW95_RS14870	COG4597	amino acid ABC transporter
GPW95_RS14875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW95_RS14885	COG1126	abc transporter atp-binding protein
GPW95_RS14890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW95_RS14900	COG0840	transmembrane signaling receptor activity
GPW95_RS14910	COG0840	transmembrane signaling receptor activity
GPW95_RS14925	COG4580	involved in the transport of maltose and maltodextrins
GPW95_RS14940	COG0363	glucosamine-6-phosphate deaminase activity
GPW95_RS14965	COG2259	Doxx family
GPW95_RS14970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPW95_RS14975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPW95_RS14985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPW95_RS14990	COG3366	ferrous iron transmembrane transporter activity
GPW95_RS14995	COG0700	Nucleoside recognition
GPW95_RS15005	COG0697	spore germination
GPW95_RS15010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW95_RS15015	COG1764	response to oxidative stress
GPW95_RS15020	COG1846	Transcriptional regulator
GPW95_RS15040	COG2207	Transcriptional regulator
GPW95_RS15045	COG1280	lysine exporter protein (LysE YggA)
GPW95_RS15055	COG1902	pentaerythritol trinitrate reductase activity
GPW95_RS15065	COG1132	(ABC) transporter
GPW95_RS15080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPW95_RS15090	COG0513	Belongs to the DEAD box helicase family
GPW95_RS15100	COG0840	transmembrane signaling receptor activity
GPW95_RS15110	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPW95_RS15120	COG1304	FMN binding
GPW95_RS15125	COG1620	l-lactate permease
GPW95_RS15130	COG0583	DNA-binding transcription factor activity
GPW95_RS15150	COG4172	Belongs to the ABC transporter superfamily
GPW95_RS15160	COG1067	ATP-dependent peptidase activity
GPW95_RS15175	COG2211	Major facilitator Superfamily
GPW95_RS15185	COG3123	guanosine phosphorylase activity
GPW95_RS15190	COG1741	Belongs to the pirin family
GPW95_RS15200	COG5001	Diguanylate cyclase
GPW95_RS15205	COG0583	DNA-binding transcription factor activity
GPW95_RS15245	COG1846	Transcriptional regulator
GPW95_RS15250	COG0835	chemotaxis
GPW95_RS15250	COG0784	Response regulator, receiver
GPW95_RS15255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW95_RS15260	COG2197	response regulator
GPW95_RS15265	COG0393	Putative heavy-metal-binding
GPW95_RS15280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW95_RS15285	COG3842	ATPase activity
GPW95_RS15295	COG1175	transmembrane transport
GPW95_RS15300	COG3833	ABC-type maltose transport systems, permease component
GPW95_RS15315	COG1349	DNA-binding transcription factor activity
GPW95_RS15320	COG3706	GGDEF domain
GPW95_RS15330	COG2207	Transcriptional regulator
GPW95_RS15330	COG4753	response regulator
GPW95_RS15345	COG1278	Cold shock
GPW95_RS15350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW95_RS15355	COG2354	Protein conserved in bacteria
GPW95_RS15360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW95_RS15365	COG0418	dihydroorotase activity
GPW95_RS15370	COG3217	Mosc domain protein beta barrel domain protein
GPW95_RS15370	COG0633	Ferredoxin
GPW95_RS15370	COG0633	Ferredoxin
GPW95_RS15370	COG3217	Mosc domain protein beta barrel domain protein
GPW95_RS15405	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPW95_RS15415	COG4558	Periplasmic binding protein
GPW95_RS15420	COG0848	biopolymer transport protein
GPW95_RS15425	COG0811	peptide transport
GPW95_RS15430	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW95_RS15440	COG3721	Heme iron utilization protein
GPW95_RS15445	COG0748	coenzyme F420 binding
GPW95_RS15455	COG1929	Belongs to the glycerate kinase type-1 family
GPW95_RS15480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPW95_RS15485	COG0363	glucosamine-6-phosphate deaminase activity
GPW95_RS15490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPW95_RS15520	COG0346	lactoylglutathione lyase activity
GPW95_RS15530	COG2873	o-acetylhomoserine
GPW95_RS15535	COG0156	8-amino-7-oxononanoate synthase activity
GPW95_RS15540	COG1063	alcohol dehydrogenase
GPW95_RS15545	COG0789	Transcriptional regulator
GPW95_RS15560	COG0583	DNA-binding transcription factor activity
GPW95_RS15565	COG3048	D-serine ammonia-lyase activity
GPW95_RS15575	COG1278	Cold shock
GPW95_RS15580	COG0557	exoribonuclease II activity
GPW95_RS15585	COG1686	Belongs to the peptidase S11 family
GPW95_RS15595	COG3047	cAMP biosynthetic process
GPW95_RS15605	COG3227	Zinc metalloprotease (Elastase)
GPW95_RS15620	COG2067	long-chain fatty acid transport protein
GPW95_RS15635	COG4989	oxidoreductase activity
GPW95_RS15670	COG3706	GGDEF domain
GPW95_RS15675	COG0531	amino acid
GPW95_RS15710	COG1765	OsmC-like protein
GPW95_RS15715	COG1253	flavin adenine dinucleotide binding
GPW95_RS15720	COG2171	N-acyltransferase activity
GPW95_RS15735	COG0583	DNA-binding transcription factor activity
GPW95_RS15740	COG2264	protein methyltransferase activity
GPW95_RS15755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW95_RS15760	COG3186	Phenylalanine-4-hydroxylase
GPW95_RS15765	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPW95_RS15770	COG0456	acetyltransferase
GPW95_RS15775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPW95_RS15780	COG0662	Cupin 2, conserved barrel domain protein
GPW95_RS15785	COG0527	aspartate kinase activity
GPW95_RS15795	COG0459	protein refolding
GPW95_RS15800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW95_RS15805	COG2239	Acts as a magnesium transporter
GPW95_RS15815	COG1166	arginine decarboxylase activity
GPW95_RS15820	COG0010	Belongs to the arginase family
GPW95_RS15830	COG3227	Zinc metalloprotease (Elastase)
GPW95_RS15835	COG3397	chitin binding
GPW95_RS15840	COG3046	protein related to deoxyribodipyrimidine photolyase
GPW95_RS15850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW95_RS15860	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPW95_RS15865	COG0513	Belongs to the DEAD box helicase family
GPW95_RS15875	COG1368	sulfuric ester hydrolase activity
GPW95_RS15880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW95_RS15895	COG0546	phosphoglycolate phosphatase activity
GPW95_RS15930	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW95_RS15940	COG4181	ATPase activity
GPW95_RS15960	COG1984	allophanate hydrolase subunit 2
GPW95_RS15970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPW95_RS15980	COG0840	transmembrane signaling receptor activity
GPW95_RS15985	COG0814	amino acid
GPW95_RS15995	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPW95_RS16000	COG0513	Belongs to the DEAD box helicase family
GPW95_RS16005	COG1309	transcriptional regulator
GPW95_RS16015	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPW95_RS16020	COG0494	nUDIX hydrolase
GPW95_RS16030	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPW95_RS16040	COG1126	abc transporter atp-binding protein
GPW95_RS16045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW95_RS16050	COG4215	(ABC) transporter
GPW95_RS16055	COG4160	amino acid transport
GPW95_RS16060	COG0583	DNA-binding transcription factor activity
GPW95_RS16090	COG3118	belongs to the thioredoxin family
GPW95_RS16095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW95_RS16100	COG0247	lactate metabolic process
GPW95_RS16110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW95_RS16120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPW95_RS16125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPW95_RS16155	COG2827	Endonuclease containing a URI domain
GPW95_RS16165	COG1879	ABC-type sugar transport system periplasmic component
GPW95_RS16170	COG0784	Response regulator, receiver
GPW95_RS16170	COG5002	protein histidine kinase activity
GPW95_RS16215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW95_RS16220	COG4605	iron ion homeostasis
GPW95_RS16225	COG4604	ABC transporter, ATP-binding protein
GPW95_RS16245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW95_RS16250	COG3385	transposase activity
GPW95_RS16255	COG1943	Transposase
GPW95_RS16265	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GPW95_RS16270	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPW95_RS16280	COG1401	restriction endodeoxyribonuclease activity
GPW95_RS16310	COG0583	DNA-binding transcription factor activity
GPW95_RS16325	COG0745	RESPONSE REGULATOR receiver
GPW95_RS16335	COG3623	hexulose-6-phosphate isomerase
GPW95_RS16340	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPW95_RS16345	COG0561	phosphatase activity
GPW95_RS16380	COG0366	Alpha amylase catalytic
GPW95_RS16400	COG0745	RESPONSE REGULATOR receiver
GPW95_RS16405	COG5002	protein histidine kinase activity
GPW95_RS16405	COG5000	phosphorelay sensor kinase activity
GPW95_RS16445	COG2814	Major facilitator Superfamily
GPW95_RS16460	COG1686	Belongs to the peptidase S11 family
GPW95_RS16485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW95_RS16485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW95_RS16490	COG0509	glycine decarboxylation via glycine cleavage system
GPW95_RS16495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW95_RS16505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPW95_RS16515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPW95_RS16525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPW95_RS16530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPW95_RS16665	COG0456	acetyltransferase
GPW95_RS16720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW95_RS16735	COG0384	phenazine biosynthesis protein PhzF
GPW95_RS16790	COG0456	acetyltransferase
GPW95_RS16840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW95_RS16880	COG0625	glutathione transferase activity
GPW95_RS16940	COG0456	acetyltransferase
GPW95_RS16975	COG1328	CTP reductase activity
GPW95_RS16980	COG0602	queuosine metabolic process
GPW95_RS16990	COG4067	protein conserved in archaea
GPW95_RS16990	COG0189	ligase activity
GPW95_RS16995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW95_RS16995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW95_RS16995	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPW95_RS17000	COG1105	Belongs to the carbohydrate kinase PfkB family
GPW95_RS17010	COG1609	Transcriptional regulator
GPW95_RS17015	COG0420	3'-5' exonuclease activity
GPW95_RS17020	COG0419	ATPase involved in DNA repair
GPW95_RS17025	COG2205	protein histidine kinase activity
GPW95_RS17025	COG0784	Response regulator, receiver
GPW95_RS17030	COG0156	8-amino-7-oxononanoate synthase activity
GPW95_RS17040	COG0038	chloride channel
GPW95_RS17045	COG0523	cobalamin synthesis protein
GPW95_RS17055	COG3158	transport of potassium into the cell
GPW95_RS17060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPW95_RS17060	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPW95_RS17060	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPW95_RS17060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPW95_RS17065	COG2205	protein histidine kinase activity
GPW95_RS17070	COG0745	RESPONSE REGULATOR receiver
GPW95_RS17075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW95_RS17080	COG0586	Pfam SNARE associated Golgi protein
GPW95_RS17090	COG2200	EAL domain
GPW95_RS17100	COG3038	cytochrome b561
GPW95_RS17110	COG2116	formate transmembrane transporter activity
GPW95_RS17115	COG0583	DNA-binding transcription factor activity
GPW95_RS17125	COG3593	DNA synthesis involved in DNA repair
GPW95_RS17130	COG0737	Belongs to the 5'-nucleotidase family
GPW95_RS17150	COG2824	Alkylphosphonate utilization operon protein PhnA
GPW95_RS17205	COG3706	GGDEF domain
GPW95_RS17220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPW95_RS17225	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPW95_RS17235	COG0745	RESPONSE REGULATOR receiver
GPW95_RS17365	COG4128	Pfam Zonular occludens toxin
GPW95_RS17410	COG4128	Pfam Zonular occludens toxin
GPW95_RS17415	COG0023	Translation Initiation Factor
GPW95_RS17425	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPW95_RS17435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW95_RS17435	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW95_RS17435	COG1042	CoA-binding domain protein
GPW95_RS17440	COG0583	DNA-binding transcription factor activity
GPW95_RS17445	COG1629	transport
GPW95_RS17445	COG4771	TonB-dependent receptor
GPW95_RS17460	COG2050	protein possibly involved in aromatic compounds catabolism
GPW95_RS17480	COG0625	glutathione transferase activity
GPW95_RS17495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPW95_RS17500	COG4172	Belongs to the ABC transporter superfamily
GPW95_RS17505	COG4239	(ABC) transporter, permease
GPW95_RS17510	COG4174	ABC transporter (Permease)
GPW95_RS17515	COG4166	transmembrane transport
GPW95_RS17560	COG3842	ATPase activity
GPW95_RS17570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW95_RS17580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW95_RS17585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW95_RS17590	COG1011	Hydrolase
GPW95_RS17600	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPW95_RS17610	COG1970	mechanosensitive ion channel activity
GPW95_RS17615	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPW95_RS17620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW95_RS17620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW95_RS17625	COG0302	gtp cyclohydrolase
GPW95_RS17635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW95_RS17645	COG2897	thiosulfate sulfurtransferase activity
GPW95_RS17650	COG2390	Transcriptional regulator
GPW95_RS17660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPW95_RS17665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW95_RS17690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW95_RS17715	COG0583	DNA-binding transcription factor activity
GPW95_RS17720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPW95_RS17750	COG0640	Transcriptional regulator
GPW95_RS17805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW95_RS17805	COG1263	PTS System
GPW95_RS17815	COG1621	beta-fructofuranosidase activity
GPW95_RS17820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW95_RS17825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW95_RS17835	COG2885	chlorophyll binding
GPW95_RS17840	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW95_RS17845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW95_RS17850	COG0840	transmembrane signaling receptor activity
GPW95_RS17855	COG3069	C4-dicarboxylate transmembrane transporter activity
GPW95_RS17860	COG1760	l-serine dehydratase
GPW95_RS17865	COG2197	response regulator
GPW95_RS17870	COG3850	Histidine kinase
GPW95_RS17875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW95_RS17885	COG0243	molybdopterin cofactor binding
GPW95_RS17905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW95_RS17910	COG2197	response regulator
GPW95_RS17915	COG3851	Histidine kinase
GPW95_RS17920	COG2271	Major facilitator Superfamily
GPW95_RS17925	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW95_RS17935	COG3842	ATPase activity
GPW95_RS17940	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPW95_RS17950	COG0183	Belongs to the thiolase family
GPW95_RS17960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW95_RS17980	COG3706	GGDEF domain
GPW95_RS17985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW95_RS17995	COG1979	alcohol dehydrogenase
GPW95_RS18010	COG4191	Histidine kinase
GPW95_RS18015	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW95_RS18020	COG2271	Major facilitator Superfamily
GPW95_RS18025	COG0469	pyruvate kinase activity
GPW95_RS18030	COG2198	Histidine kinase
GPW95_RS18030	COG0784	Response regulator, receiver
GPW95_RS18030	COG2205	protein histidine kinase activity
GPW95_RS18040	COG1803	Methylglyoxal synthase
GPW95_RS18045	COG1335	isochorismatase
GPW95_RS18050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPW95_RS18055	COG0210	DNA helicase
GPW95_RS18060	COG1289	transmembrane transporter activity
GPW95_RS18090	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPW95_RS18095	COG4149	molybdate abc transporter
GPW95_RS18100	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPW95_RS18105	COG1492	cobalamin metabolic process
GPW95_RS18125	COG3291	Pkd domain containing protein
GPW95_RS18125	COG4412	M6 family metalloprotease domain protein
GPW95_RS18130	COG5380	lipid catabolic process
GPW95_RS18135	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPW95_RS18140	COG0840	transmembrane signaling receptor activity
GPW95_RS18150	COG3240	lipase activity
GPW95_RS18155	COG3706	GGDEF domain
GPW95_RS18165	COG2814	Major facilitator Superfamily
GPW95_RS18170	COG1757	Na H antiporter
GPW95_RS18180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW95_RS18180	COG4191	Histidine kinase
GPW95_RS18185	COG3437	response regulator, receiver
GPW95_RS18185	COG0784	Response regulator, receiver
GPW95_RS18190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPW95_RS18195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPW95_RS18200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW95_RS18205	COG0513	Belongs to the DEAD box helicase family
GPW95_RS18230	COG0516	GMP reductase activity
GPW95_RS18240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW95_RS18250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW95_RS18280	COG3036	rescue of stalled ribosome
GPW95_RS18285	COG1278	Cold shock
GPW95_RS18290	COG1017	nitric oxide dioxygenase activity
GPW95_RS18290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW95_RS18295	COG3604	Transcriptional regulator
GPW95_RS18305	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW95_RS18325	COG0840	transmembrane signaling receptor activity
GPW95_RS18330	COG0714	Associated with various cellular activities
GPW95_RS18350	COG2304	oxidoreductase activity
GPW95_RS18365	COG1278	Cold shock
GPW95_RS18370	COG5002	protein histidine kinase activity
GPW95_RS18370	COG5001	Diguanylate cyclase
GPW95_RS18380	COG3530	Putative quorum-sensing-regulated virulence factor
GPW95_RS18390	COG3033	Beta-eliminating lyase
GPW95_RS18395	COG0814	amino acid
GPW95_RS18410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW95_RS18410	COG2111	Na H antiporter
GPW95_RS18430	COG2212	antiporter activity
GPW95_RS18435	COG1320	monovalent cation:proton antiporter activity
GPW95_RS18440	COG1017	nitric oxide dioxygenase activity
GPW95_RS18440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW95_RS18445	COG0242	peptide deformylase activity
GPW95_RS18450	COG3385	transposase activity
GPW95_RS18500	COG2271	Major facilitator Superfamily
GPW95_RS18505	COG0584	glycerophosphoryl diester phosphodiesterase
GPW95_RS18515	COG0813	purine-nucleoside phosphorylase activity
GPW95_RS18525	COG1609	Transcriptional regulator
GPW95_RS18530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW95_RS18535	COG1879	ABC-type sugar transport system periplasmic component
GPW95_RS18540	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPW95_RS18545	COG1129	ABC transporter
GPW95_RS18550	COG1869	D-ribose catabolic process
GPW95_RS18565	COG3501	Rhs element vgr protein
GPW95_RS18660	COG0564	pseudouridine synthase activity
GPW95_RS18670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW95_RS18675	COG2200	EAL domain
GPW95_RS18675	COG2771	luxR family
GPW95_RS18685	COG0673	inositol 2-dehydrogenase activity
GPW95_RS18690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPW95_RS18720	COG1342	Belongs to the UPF0251 family
GPW95_RS18730	COG1301	dicarboxylic acid transport
GPW95_RS18760	COG0583	DNA-binding transcription factor activity
GPW95_RS18765	COG3300	MHYT domain
GPW95_RS18765	COG5001	Diguanylate cyclase
GPW95_RS18770	COG0739	heme binding
GPW95_RS18785	COG0659	secondary active sulfate transmembrane transporter activity
GPW95_RS18810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW95_RS18815	COG0581	inorganic phosphate transmembrane transporter activity
GPW95_RS18820	COG0573	inorganic phosphate transmembrane transporter activity
GPW95_RS18825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW95_RS18855	COG1770	oligopeptidase
GPW95_RS18860	COG0513	Belongs to the DEAD box helicase family
GPW95_RS18870	COG1388	LysM domain
GPW95_RS18870	COG1376	ErfK ybiS ycfS ynhG family protein
GPW95_RS18875	COG0415	Belongs to the DNA photolyase family
GPW95_RS18885	COG3272	Protein of unknown function (DUF1722)
GPW95_RS18890	COG0813	purine-nucleoside phosphorylase activity
GPW95_RS18905	COG3706	GGDEF domain
GPW95_RS18925	COG0786	glutamate:sodium symporter activity
GPW95_RS18940	COG1999	signal sequence binding
GPW95_RS18950	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPW95_RS18955	COG0671	phosphoesterase, PA-phosphatase related
GPW95_RS19000	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW95_RS19005	COG3385	transposase activity