locus-tag	class	description
GPW72_RS00005	COG0531	amino acid
GPW72_RS00015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW72_RS00020	COG1901	pseudouridine methyltransferase
GPW72_RS00030	COG4221	oxidoreductase activity
GPW72_RS00035	COG0840	transmembrane signaling receptor activity
GPW72_RS00045	COG2910	NAD(P)H-binding
GPW72_RS00075	COG0673	inositol 2-dehydrogenase activity
GPW72_RS00080	COG3722	fumarate hydratase activity
GPW72_RS00085	COG0246	Mannitol dehydrogenase
GPW72_RS00090	COG2213	PTS system mannitol-specific
GPW72_RS00090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW72_RS00110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW72_RS00115	COG4597	amino acid ABC transporter
GPW72_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW72_RS00130	COG1126	abc transporter atp-binding protein
GPW72_RS00135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW72_RS00145	COG0840	transmembrane signaling receptor activity
GPW72_RS00160	COG0840	transmembrane signaling receptor activity
GPW72_RS00175	COG4580	involved in the transport of maltose and maltodextrins
GPW72_RS00190	COG0363	glucosamine-6-phosphate deaminase activity
GPW72_RS00215	COG2259	Doxx family
GPW72_RS00220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPW72_RS00225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPW72_RS00235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPW72_RS00240	COG3366	ferrous iron transmembrane transporter activity
GPW72_RS00245	COG0700	Nucleoside recognition
GPW72_RS00255	COG0697	spore germination
GPW72_RS00260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW72_RS00265	COG1764	response to oxidative stress
GPW72_RS00270	COG1846	Transcriptional regulator
GPW72_RS00290	COG2207	Transcriptional regulator
GPW72_RS00295	COG1280	lysine exporter protein (LysE YggA)
GPW72_RS00305	COG1902	pentaerythritol trinitrate reductase activity
GPW72_RS00315	COG1132	(ABC) transporter
GPW72_RS00325	COG1902	pentaerythritol trinitrate reductase activity
GPW72_RS00335	COG0583	DNA-binding transcription factor activity
GPW72_RS00340	COG0513	Belongs to the DEAD box helicase family
GPW72_RS00350	COG0840	transmembrane signaling receptor activity
GPW72_RS00360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPW72_RS00370	COG1304	FMN binding
GPW72_RS00375	COG1620	l-lactate permease
GPW72_RS00380	COG0583	DNA-binding transcription factor activity
GPW72_RS00400	COG4172	Belongs to the ABC transporter superfamily
GPW72_RS00410	COG1067	ATP-dependent peptidase activity
GPW72_RS00415	COG0840	transmembrane signaling receptor activity
GPW72_RS00425	COG2211	Major facilitator Superfamily
GPW72_RS00435	COG3123	guanosine phosphorylase activity
GPW72_RS00440	COG1741	Belongs to the pirin family
GPW72_RS00450	COG5001	Diguanylate cyclase
GPW72_RS00455	COG0583	DNA-binding transcription factor activity
GPW72_RS00490	COG3706	GGDEF domain
GPW72_RS00495	COG1846	Transcriptional regulator
GPW72_RS00500	COG0835	chemotaxis
GPW72_RS00500	COG0784	Response regulator, receiver
GPW72_RS00505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW72_RS00510	COG2197	response regulator
GPW72_RS00515	COG0393	Putative heavy-metal-binding
GPW72_RS00530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW72_RS00535	COG3842	ATPase activity
GPW72_RS00545	COG1175	transmembrane transport
GPW72_RS00550	COG3833	ABC-type maltose transport systems, permease component
GPW72_RS00565	COG1349	DNA-binding transcription factor activity
GPW72_RS00570	COG3706	GGDEF domain
GPW72_RS00595	COG1278	Cold shock
GPW72_RS00600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW72_RS00605	COG2354	Protein conserved in bacteria
GPW72_RS00610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW72_RS00620	COG3152	Membrane
GPW72_RS00630	COG0418	dihydroorotase activity
GPW72_RS00635	COG0633	Ferredoxin
GPW72_RS00635	COG3217	Mosc domain protein beta barrel domain protein
GPW72_RS00635	COG0633	Ferredoxin
GPW72_RS00635	COG3217	Mosc domain protein beta barrel domain protein
GPW72_RS00670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPW72_RS00675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW72_RS00680	COG4558	Periplasmic binding protein
GPW72_RS00685	COG0848	biopolymer transport protein
GPW72_RS00690	COG0811	peptide transport
GPW72_RS00695	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW72_RS00705	COG3721	Heme iron utilization protein
GPW72_RS00710	COG0748	coenzyme F420 binding
GPW72_RS00720	COG3835	regulator
GPW72_RS00725	COG2610	gluconate transmembrane transporter activity
GPW72_RS00730	COG1929	Belongs to the glycerate kinase type-1 family
GPW72_RS00755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPW72_RS00760	COG0363	glucosamine-6-phosphate deaminase activity
GPW72_RS00765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPW72_RS00770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW72_RS00795	COG0346	lactoylglutathione lyase activity
GPW72_RS00805	COG2873	o-acetylhomoserine
GPW72_RS00815	COG1063	alcohol dehydrogenase
GPW72_RS00860	COG0583	DNA-binding transcription factor activity
GPW72_RS00865	COG3048	D-serine ammonia-lyase activity
GPW72_RS00880	COG1294	oxidase, subunit
GPW72_RS00885	COG1271	oxidase subunit
GPW72_RS00890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPW72_RS00895	COG1686	Belongs to the peptidase S11 family
GPW72_RS00915	COG3227	Zinc metalloprotease (Elastase)
GPW72_RS00925	COG2267	carboxylic ester hydrolase activity
GPW72_RS00930	COG2067	long-chain fatty acid transport protein
GPW72_RS00940	COG0366	Alpha amylase catalytic
GPW72_RS00945	COG4989	oxidoreductase activity
GPW72_RS00960	COG1136	(ABC) transporter
GPW72_RS00965	COG1136	(ABC) transporter
GPW72_RS00965	COG0577	efflux transmembrane transporter activity
GPW72_RS00980	COG3275	phosphorelay sensor kinase activity
GPW72_RS00985	COG3279	Response regulator of the LytR AlgR family
GPW72_RS00995	COG3706	GGDEF domain
GPW72_RS01000	COG0531	amino acid
GPW72_RS01025	COG1765	OsmC-like protein
GPW72_RS01030	COG1253	flavin adenine dinucleotide binding
GPW72_RS01035	COG2171	N-acyltransferase activity
GPW72_RS01050	COG0583	DNA-binding transcription factor activity
GPW72_RS01055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW72_RS01070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW72_RS01075	COG3186	Phenylalanine-4-hydroxylase
GPW72_RS01080	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPW72_RS01085	COG0456	acetyltransferase
GPW72_RS01090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPW72_RS01095	COG0662	Cupin 2, conserved barrel domain protein
GPW72_RS01100	COG0527	aspartate kinase activity
GPW72_RS01110	COG0459	protein refolding
GPW72_RS01115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW72_RS01120	COG2239	Acts as a magnesium transporter
GPW72_RS01135	COG1166	arginine decarboxylase activity
GPW72_RS01140	COG0010	Belongs to the arginase family
GPW72_RS01150	COG3227	Zinc metalloprotease (Elastase)
GPW72_RS01155	COG3397	chitin binding
GPW72_RS01160	COG3046	protein related to deoxyribodipyrimidine photolyase
GPW72_RS01170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW72_RS01180	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPW72_RS01185	COG0513	Belongs to the DEAD box helicase family
GPW72_RS01195	COG1368	sulfuric ester hydrolase activity
GPW72_RS01200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW72_RS01215	COG0546	phosphoglycolate phosphatase activity
GPW72_RS01255	COG0484	heat shock protein binding
GPW72_RS01270	COG1716	ATPase activity
GPW72_RS01270	COG5001	Diguanylate cyclase
GPW72_RS01275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW72_RS01285	COG4181	ATPase activity
GPW72_RS01290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPW72_RS01305	COG1984	allophanate hydrolase subunit 2
GPW72_RS01315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPW72_RS01320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPW72_RS01325	COG0840	transmembrane signaling receptor activity
GPW72_RS01330	COG0814	amino acid
GPW72_RS01340	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPW72_RS01345	COG0513	Belongs to the DEAD box helicase family
GPW72_RS01350	COG1309	transcriptional regulator
GPW72_RS01360	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPW72_RS01365	COG0494	nUDIX hydrolase
GPW72_RS01375	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPW72_RS01385	COG1126	abc transporter atp-binding protein
GPW72_RS01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW72_RS01395	COG4215	(ABC) transporter
GPW72_RS01400	COG4160	amino acid transport
GPW72_RS01405	COG0583	DNA-binding transcription factor activity
GPW72_RS01435	COG3118	belongs to the thioredoxin family
GPW72_RS01440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW72_RS01445	COG0247	lactate metabolic process
GPW72_RS01450	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPW72_RS01455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW72_RS01460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPW72_RS01495	COG2827	Endonuclease containing a URI domain
GPW72_RS01505	COG1879	ABC-type sugar transport system periplasmic component
GPW72_RS01510	COG5002	protein histidine kinase activity
GPW72_RS01510	COG0784	Response regulator, receiver
GPW72_RS01555	COG1492	cobalamin metabolic process
GPW72_RS01560	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPW72_RS01565	COG4149	molybdate abc transporter
GPW72_RS01570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPW72_RS01600	COG1289	transmembrane transporter activity
GPW72_RS01605	COG0210	DNA helicase
GPW72_RS01620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPW72_RS01625	COG1335	isochorismatase
GPW72_RS01630	COG1803	Methylglyoxal synthase
GPW72_RS01635	COG1879	ABC-type sugar transport system periplasmic component
GPW72_RS01640	COG0784	Response regulator, receiver
GPW72_RS01640	COG2198	Histidine kinase
GPW72_RS01640	COG2205	protein histidine kinase activity
GPW72_RS01645	COG0469	pyruvate kinase activity
GPW72_RS01650	COG2271	Major facilitator Superfamily
GPW72_RS01655	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW72_RS01660	COG4191	Histidine kinase
GPW72_RS01675	COG1979	alcohol dehydrogenase
GPW72_RS01685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW72_RS01690	COG3706	GGDEF domain
GPW72_RS01705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW72_RS01710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW72_RS01720	COG0183	Belongs to the thiolase family
GPW72_RS01730	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPW72_RS01735	COG3842	ATPase activity
GPW72_RS01745	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW72_RS01750	COG2271	Major facilitator Superfamily
GPW72_RS01755	COG3851	Histidine kinase
GPW72_RS01760	COG2197	response regulator
GPW72_RS01765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW72_RS01785	COG0243	molybdopterin cofactor binding
GPW72_RS01795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW72_RS01800	COG3850	Histidine kinase
GPW72_RS01805	COG2197	response regulator
GPW72_RS01810	COG1609	Transcriptional regulator
GPW72_RS01830	COG1760	l-serine dehydratase
GPW72_RS01835	COG3069	C4-dicarboxylate transmembrane transporter activity
GPW72_RS01840	COG0840	transmembrane signaling receptor activity
GPW72_RS01845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW72_RS01850	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW72_RS01855	COG2885	chlorophyll binding
GPW72_RS01865	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW72_RS01870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW72_RS01875	COG1621	beta-fructofuranosidase activity
GPW72_RS01885	COG1263	PTS System
GPW72_RS01885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW72_RS01930	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW72_RS01940	COG0640	Transcriptional regulator
GPW72_RS01965	COG0778	Nitroreductase
GPW72_RS01970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPW72_RS01975	COG0583	DNA-binding transcription factor activity
GPW72_RS02000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW72_RS02025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW72_RS02030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPW72_RS02040	COG2390	Transcriptional regulator
GPW72_RS02045	COG2897	thiosulfate sulfurtransferase activity
GPW72_RS02055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW72_RS02065	COG0302	gtp cyclohydrolase
GPW72_RS02070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW72_RS02070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW72_RS02075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPW72_RS02080	COG1970	mechanosensitive ion channel activity
GPW72_RS02085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPW72_RS02095	COG1011	Hydrolase
GPW72_RS02100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW72_RS02105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW72_RS02115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW72_RS02125	COG3842	ATPase activity
GPW72_RS02170	COG4166	transmembrane transport
GPW72_RS02175	COG4174	ABC transporter (Permease)
GPW72_RS02180	COG4239	(ABC) transporter, permease
GPW72_RS02185	COG4172	Belongs to the ABC transporter superfamily
GPW72_RS02190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPW72_RS02205	COG0625	glutathione transferase activity
GPW72_RS02225	COG2050	protein possibly involved in aromatic compounds catabolism
GPW72_RS02240	COG1629	transport
GPW72_RS02240	COG4771	TonB-dependent receptor
GPW72_RS02245	COG0583	DNA-binding transcription factor activity
GPW72_RS02250	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW72_RS02250	COG1042	CoA-binding domain protein
GPW72_RS02250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW72_RS02260	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPW72_RS02270	COG0023	Translation Initiation Factor
GPW72_RS02290	COG0745	RESPONSE REGULATOR receiver
GPW72_RS02300	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPW72_RS02305	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPW72_RS02320	COG3706	GGDEF domain
GPW72_RS02375	COG2824	Alkylphosphonate utilization operon protein PhnA
GPW72_RS02395	COG0737	Belongs to the 5'-nucleotidase family
GPW72_RS02400	COG3593	DNA synthesis involved in DNA repair
GPW72_RS02410	COG0583	DNA-binding transcription factor activity
GPW72_RS02415	COG2116	formate transmembrane transporter activity
GPW72_RS02425	COG3038	cytochrome b561
GPW72_RS02435	COG2200	EAL domain
GPW72_RS02445	COG0586	Pfam SNARE associated Golgi protein
GPW72_RS02450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW72_RS02455	COG0745	RESPONSE REGULATOR receiver
GPW72_RS02460	COG2205	protein histidine kinase activity
GPW72_RS02465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPW72_RS02465	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPW72_RS02465	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPW72_RS02465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPW72_RS02470	COG3158	transport of potassium into the cell
GPW72_RS02480	COG0523	cobalamin synthesis protein
GPW72_RS02485	COG0038	chloride channel
GPW72_RS02495	COG0156	8-amino-7-oxononanoate synthase activity
GPW72_RS02500	COG0784	Response regulator, receiver
GPW72_RS02500	COG2205	protein histidine kinase activity
GPW72_RS02505	COG0419	ATPase involved in DNA repair
GPW72_RS02510	COG0420	3'-5' exonuclease activity
GPW72_RS02515	COG1609	Transcriptional regulator
GPW72_RS02520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW72_RS02520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW72_RS02525	COG1105	Belongs to the carbohydrate kinase PfkB family
GPW72_RS02530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW72_RS02530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW72_RS02530	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPW72_RS02535	COG4067	protein conserved in archaea
GPW72_RS02535	COG0189	ligase activity
GPW72_RS02545	COG0602	queuosine metabolic process
GPW72_RS02550	COG1328	CTP reductase activity
GPW72_RS02575	COG0346	lactoylglutathione lyase activity
GPW72_RS02710	COG0346	lactoylglutathione lyase activity
GPW72_RS02730	COG0110	maltose O-acetyltransferase activity
GPW72_RS02735	COG3039	Transposase
GPW72_RS02750	COG2944	sequence-specific DNA binding
GPW72_RS02755	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GPW72_RS02845	COG4977	sequence-specific DNA binding
GPW72_RS02850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GPW72_RS02910	COG3040	lipid binding
GPW72_RS02935	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPW72_RS03055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW72_RS03155	COG3040	lipid binding
GPW72_RS03185	COG0346	lactoylglutathione lyase activity
GPW72_RS03215	COG0384	phenazine biosynthesis protein PhzF
GPW72_RS03235	COG3093	addiction module antidote protein HigA
GPW72_RS03240	COG3549	Plasmid maintenance system killer
GPW72_RS03360	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPW72_RS03425	COG1418	mRNA catabolic process
GPW72_RS03470	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPW72_RS03530	COG0346	lactoylglutathione lyase activity
GPW72_RS03575	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPW72_RS03580	COG0456	acetyltransferase
GPW72_RS03680	COG0456	acetyltransferase
GPW72_RS03720	COG3041	Addiction module toxin RelE StbE family
GPW72_RS03740	COG3040	lipid binding
GPW72_RS03750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPW72_RS03815	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPW72_RS03865	COG3093	addiction module antidote protein HigA
GPW72_RS03870	COG3549	Plasmid maintenance system killer
GPW72_RS03880	COG0346	lactoylglutathione lyase activity
GPW72_RS03895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPW72_RS03900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPW72_RS03910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPW72_RS03935	COG3039	Transposase
GPW72_RS03945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPW72_RS03955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW72_RS03960	COG0509	glycine decarboxylation via glycine cleavage system
GPW72_RS03965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW72_RS03965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW72_RS03970	COG3338	carbonate dehydratase activity
GPW72_RS03985	COG1686	Belongs to the peptidase S11 family
GPW72_RS04000	COG2814	Major facilitator Superfamily
GPW72_RS04015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPW72_RS04040	COG5002	protein histidine kinase activity
GPW72_RS04045	COG0745	RESPONSE REGULATOR receiver
GPW72_RS04070	COG0366	Alpha amylase catalytic
GPW72_RS04075	COG3038	cytochrome b561
GPW72_RS04105	COG0561	phosphatase activity
GPW72_RS04110	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPW72_RS04115	COG3623	hexulose-6-phosphate isomerase
GPW72_RS04125	COG0745	RESPONSE REGULATOR receiver
GPW72_RS04145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW72_RS04165	COG4604	ABC transporter, ATP-binding protein
GPW72_RS04170	COG4605	iron ion homeostasis
GPW72_RS04175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW72_RS04195	COG3291	Pkd domain containing protein
GPW72_RS04195	COG4412	M6 family metalloprotease domain protein
GPW72_RS04200	COG5380	lipid catabolic process
GPW72_RS04205	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPW72_RS04210	COG0840	transmembrane signaling receptor activity
GPW72_RS04220	COG3240	lipase activity
GPW72_RS04225	COG3706	GGDEF domain
GPW72_RS04235	COG2814	Major facilitator Superfamily
GPW72_RS04240	COG1757	Na H antiporter
GPW72_RS04250	COG4191	Histidine kinase
GPW72_RS04250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW72_RS04255	COG3437	response regulator, receiver
GPW72_RS04255	COG0784	Response regulator, receiver
GPW72_RS04265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPW72_RS04270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPW72_RS04275	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW72_RS04280	COG0513	Belongs to the DEAD box helicase family
GPW72_RS04295	COG1943	Transposase
GPW72_RS04320	COG0516	GMP reductase activity
GPW72_RS04330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW72_RS04340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW72_RS04345	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPW72_RS04345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPW72_RS04370	COG3036	rescue of stalled ribosome
GPW72_RS04375	COG1278	Cold shock
GPW72_RS04380	COG1017	nitric oxide dioxygenase activity
GPW72_RS04380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW72_RS04385	COG3604	Transcriptional regulator
GPW72_RS04395	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW72_RS04400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW72_RS04415	COG0840	transmembrane signaling receptor activity
GPW72_RS04420	COG0714	Associated with various cellular activities
GPW72_RS04440	COG2304	oxidoreductase activity
GPW72_RS04455	COG1278	Cold shock
GPW72_RS04460	COG5002	protein histidine kinase activity
GPW72_RS04460	COG5001	Diguanylate cyclase
GPW72_RS04470	COG3530	Putative quorum-sensing-regulated virulence factor
GPW72_RS04480	COG3033	Beta-eliminating lyase
GPW72_RS04485	COG0814	amino acid
GPW72_RS04490	COG0589	response to stress
GPW72_RS04500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW72_RS04500	COG2111	Na H antiporter
GPW72_RS04520	COG2212	antiporter activity
GPW72_RS04525	COG1320	monovalent cation:proton antiporter activity
GPW72_RS04535	COG0242	peptide deformylase activity
GPW72_RS04545	COG0579	oxidoreductase
GPW72_RS04585	COG2271	Major facilitator Superfamily
GPW72_RS04590	COG0584	glycerophosphoryl diester phosphodiesterase
GPW72_RS04600	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPW72_RS04610	COG1609	Transcriptional regulator
GPW72_RS04615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW72_RS04620	COG1879	ABC-type sugar transport system periplasmic component
GPW72_RS04625	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPW72_RS04630	COG1129	ABC transporter
GPW72_RS04635	COG1869	D-ribose catabolic process
GPW72_RS04650	COG3501	Rhs element vgr protein
GPW72_RS04745	COG0564	pseudouridine synthase activity
GPW72_RS04755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW72_RS04760	COG2200	EAL domain
GPW72_RS04760	COG2771	luxR family
GPW72_RS04770	COG0673	inositol 2-dehydrogenase activity
GPW72_RS04775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPW72_RS04805	COG1342	Belongs to the UPF0251 family
GPW72_RS04815	COG1301	dicarboxylic acid transport
GPW72_RS04840	COG2814	Major facilitator Superfamily
GPW72_RS04845	COG0583	DNA-binding transcription factor activity
GPW72_RS04850	COG3300	MHYT domain
GPW72_RS04850	COG5001	Diguanylate cyclase
GPW72_RS04855	COG0739	heme binding
GPW72_RS04865	COG0659	secondary active sulfate transmembrane transporter activity
GPW72_RS04885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW72_RS04890	COG0581	inorganic phosphate transmembrane transporter activity
GPW72_RS04895	COG0573	inorganic phosphate transmembrane transporter activity
GPW72_RS04900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW72_RS04930	COG1770	oligopeptidase
GPW72_RS04935	COG0513	Belongs to the DEAD box helicase family
GPW72_RS04945	COG1376	ErfK ybiS ycfS ynhG family protein
GPW72_RS04945	COG1388	LysM domain
GPW72_RS04950	COG0415	Belongs to the DNA photolyase family
GPW72_RS04960	COG3272	Protein of unknown function (DUF1722)
GPW72_RS04965	COG0813	purine-nucleoside phosphorylase activity
GPW72_RS04980	COG3706	GGDEF domain
GPW72_RS04990	COG1566	PFAM secretion protein HlyD family protein
GPW72_RS05010	COG0786	glutamate:sodium symporter activity
GPW72_RS05025	COG1999	signal sequence binding
GPW72_RS05035	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPW72_RS05040	COG0671	phosphoesterase, PA-phosphatase related
GPW72_RS05085	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW72_RS05090	COG0471	metal ion transport
GPW72_RS05125	COG3501	Rhs element vgr protein
GPW72_RS05135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPW72_RS05140	COG1640	4-alpha-glucanotransferase
GPW72_RS05145	COG0058	SHG alpha-glucan phosphorylase activity
GPW72_RS05150	COG2909	trisaccharide binding
GPW72_RS05170	COG2084	Dehydrogenase
GPW72_RS05175	COG0217	transcriptional regulatory protein
GPW72_RS05210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW72_RS05215	COG1444	tRNA N-acetyltransferase activity
GPW72_RS05245	COG0745	RESPONSE REGULATOR receiver
GPW72_RS05250	COG0642	Histidine kinase
GPW72_RS05255	COG2194	sulfuric ester hydrolase activity
GPW72_RS05265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW72_RS05270	COG0601	transmembrane transport
GPW72_RS05290	COG0643	Histidine kinase
GPW72_RS05290	COG2198	Histidine kinase
GPW72_RS05295	COG0835	chemotaxis
GPW72_RS05300	COG0835	chemotaxis
GPW72_RS05305	COG0840	transmembrane signaling receptor activity
GPW72_RS05310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW72_RS05315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPW72_RS05335	COG0745	RESPONSE REGULATOR receiver
GPW72_RS05365	COG0259	pyridoxamine-phosphate oxidase activity
GPW72_RS05375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPW72_RS05400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW72_RS05430	COG1982	Orn Lys Arg decarboxylase major
GPW72_RS05440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW72_RS05445	COG0121	glutamine amidotransferase
GPW72_RS05450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPW72_RS05455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPW72_RS05460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPW72_RS05465	COG3706	GGDEF domain
GPW72_RS05470	COG1187	pseudouridine synthase activity
GPW72_RS05475	COG2840	Smr protein MutS2
GPW72_RS05490	COG3735	TraB family
GPW72_RS05505	COG2608	mercury ion transmembrane transporter activity
GPW72_RS05505	COG2217	Heavy metal translocating P-type atpase
GPW72_RS05510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW72_RS05525	COG4774	siderophore transport
GPW72_RS05525	COG1629	transport
GPW72_RS05530	COG2375	cellular response to nickel ion
GPW72_RS05535	COG2226	methyltransferase
GPW72_RS05535	COG3433	isochorismatase activity
GPW72_RS05535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPW72_RS05570	COG0784	Response regulator, receiver
GPW72_RS05570	COG0835	chemotaxis
GPW72_RS05575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW72_RS05580	COG1815	bacterial-type flagellum-dependent cell motility
GPW72_RS05585	COG1558	bacterial-type flagellum-dependent cell motility
GPW72_RS05590	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPW72_RS05595	COG1749	Flagellar hook protein flgE
GPW72_RS05600	COG4787	bacterial-type flagellum-dependent cell motility
GPW72_RS05605	COG4786	Flagellar basal body rod
GPW72_RS05610	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPW72_RS05615	COG1706	bacterial-type flagellum-dependent cell motility
GPW72_RS05620	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPW72_RS05620	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPW72_RS05640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW72_RS05645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW72_RS05730	COG0012	GTP binding
GPW72_RS05735	COG0193	aminoacyl-tRNA hydrolase activity
GPW72_RS05740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPW72_RS05745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPW72_RS05750	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPW72_RS05755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPW72_RS05760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPW72_RS05765	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW72_RS05770	COG3094	Invasion gene expression up-regulator, SirB
GPW72_RS05775	COG2912	Transglutaminase-like superfamily
GPW72_RS05780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPW72_RS05785	COG0737	Belongs to the 5'-nucleotidase family
GPW72_RS05790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPW72_RS05795	COG2233	PERMEase
GPW72_RS05815	COG1393	Belongs to the ArsC family
GPW72_RS05820	COG4783	chaperone-mediated protein folding
GPW72_RS05840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPW72_RS05850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW72_RS05855	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPW72_RS05865	COG1876	peptidase activity
GPW72_RS05870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW72_RS05875	COG1393	Belongs to the ArsC family
GPW72_RS05895	COG2837	iron assimilation
GPW72_RS05900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW72_RS05905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW72_RS05910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW72_RS05915	COG1334	flagellar protein FlaG
GPW72_RS05920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPW72_RS05930	COG1516	flagellar protein fliS
GPW72_RS05935	COG2204	response regulator
GPW72_RS05940	COG4191	Histidine kinase
GPW72_RS05945	COG2204	response regulator
GPW72_RS05950	COG1677	Flagellar hook-basal body complex protein FliE
GPW72_RS05960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPW72_RS05990	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW72_RS06015	COG1987	bacterial-type flagellum assembly
GPW72_RS06020	COG1684	flagellar biosynthetic protein fliR
GPW72_RS06035	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW72_RS06040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPW72_RS06045	COG2860	membrane
GPW72_RS06050	COG3101	peptidyl-lysine hydroxylation
GPW72_RS06060	COG0431	NADPH-dependent FMN reductase
GPW72_RS06065	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPW72_RS06065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW72_RS06070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW72_RS06075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW72_RS06080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW72_RS06085	COG0735	belongs to the Fur family
GPW72_RS06095	COG0583	DNA-binding transcription factor activity
GPW72_RS06105	COG1346	cytolysis
GPW72_RS06120	COG0596	Alpha beta hydrolase
GPW72_RS06125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPW72_RS06130	COG0033	Phosphoglucomutase
GPW72_RS06140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPW72_RS06145	COG0372	Belongs to the citrate synthase family
GPW72_RS06150	COG2009	succinate dehydrogenase
GPW72_RS06155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPW72_RS06160	COG1053	succinate dehydrogenase
GPW72_RS06170	COG0567	Dehydrogenase, E1 component
GPW72_RS06175	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW72_RS06180	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW72_RS06190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPW72_RS06195	COG1121	(ABC) transporter
GPW72_RS06200	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPW72_RS06205	COG4977	sequence-specific DNA binding
GPW72_RS06210	COG1918	ferrous iron import across plasma membrane
GPW72_RS06230	COG0018	arginyl-trna synthetase
GPW72_RS06240	COG1025	Belongs to the peptidase M16 family
GPW72_RS06245	COG2062	phosphohistidine phosphatase, SixA
GPW72_RS06260	COG0455	bacterial-type flagellum organization
GPW72_RS06275	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPW72_RS06280	COG2198	Histidine kinase
GPW72_RS06280	COG0643	Histidine kinase
GPW72_RS06285	COG2201	protein-glutamate methylesterase activity
GPW72_RS06290	COG1192	Involved in chromosome partitioning
GPW72_RS06300	COG0835	chemotaxis
GPW72_RS06310	COG4133	protoheme IX ABC transporter activity
GPW72_RS06315	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW72_RS06320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW72_RS06330	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPW72_RS06335	COG1138	Cytochrome C-type biogenesis protein
GPW72_RS06340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPW72_RS06355	COG2853	Lipoprotein
GPW72_RS06375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPW72_RS06380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW72_RS06385	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPW72_RS06400	COG3083	sulfuric ester hydrolase activity
GPW72_RS06410	COG3081	Nucleoid-associated protein
GPW72_RS06420	COG1757	Na H antiporter
GPW72_RS06425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW72_RS06430	COG2095	MarC family integral membrane protein
GPW72_RS06435	COG1454	alcohol dehydrogenase
GPW72_RS06435	COG1012	belongs to the aldehyde dehydrogenase family
GPW72_RS06445	COG0659	secondary active sulfate transmembrane transporter activity
GPW72_RS06450	COG1530	ribonuclease E activity
GPW72_RS06455	COG0564	pseudouridine synthase activity
GPW72_RS06460	COG0424	maF-like protein
GPW72_RS06465	COG1399	metal-binding, possibly nucleic acid-binding protein
GPW72_RS06470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPW72_RS06475	COG0416	fatty acid biosynthetic process
GPW72_RS06480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW72_RS06485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPW72_RS06490	COG1028	Short-chain dehydrogenase reductase Sdr
GPW72_RS06495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPW72_RS06500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW72_RS06505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW72_RS06510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPW72_RS06515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPW72_RS06525	COG0084	hydrolase, TatD family'
GPW72_RS06530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW72_RS06530	COG1263	PTS System
GPW72_RS06540	COG0733	neurotransmitter:sodium symporter activity
GPW72_RS06555	COG4667	esterase of the alpha-beta hydrolase superfamily
GPW72_RS06565	COG1940	carbohydrate kinase activity
GPW72_RS06570	COG0784	Response regulator, receiver
GPW72_RS06570	COG0835	chemotaxis
GPW72_RS06585	COG2226	methyltransferase
GPW72_RS06595	COG0676	glucose-6-phosphate 1-epimerase activity
GPW72_RS06600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW72_RS06605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW72_RS06615	COG3139	Protein of unknown function (DUF1315)
GPW72_RS06620	COG0252	asparaginase activity
GPW72_RS06625	COG0616	signal peptide processing
GPW72_RS06630	COG1902	pentaerythritol trinitrate reductase activity
GPW72_RS06630	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW72_RS06635	COG0788	formyltetrahydrofolate deformylase activity
GPW72_RS06645	COG1199	ATP-dependent helicase activity
GPW72_RS06650	COG1214	PFAM Peptidase M22, glycoprotease
GPW72_RS06665	COG0596	Alpha beta hydrolase
GPW72_RS06670	COG0318	PFAM AMP-dependent synthetase and ligase
GPW72_RS06675	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPW72_RS06695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPW72_RS06700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPW72_RS06705	COG0436	Aminotransferase
GPW72_RS06710	COG1169	isochorismate synthase
GPW72_RS06715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPW72_RS06720	COG0596	Alpha beta hydrolase
GPW72_RS06730	COG1441	menaquinone biosynthetic process
GPW72_RS06740	COG3135	benzoate transporter
GPW72_RS06745	COG1396	sequence-specific DNA binding
GPW72_RS06750	COG0840	transmembrane signaling receptor activity
GPW72_RS06755	COG0477	Major facilitator Superfamily
GPW72_RS06775	COG3015	lipoprotein NlpE involved in copper resistance
GPW72_RS06780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPW72_RS06785	COG2894	cell division
GPW72_RS06790	COG0850	regulation of cytokinetic process
GPW72_RS06795	COG3100	YcgL domain-containing protein
GPW72_RS06800	COG2951	lytic endotransglycosylase activity
GPW72_RS06810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW72_RS06815	COG3325	Belongs to the glycosyl hydrolase 18 family
GPW72_RS06815	COG3469	chitinase activity
GPW72_RS06820	COG3005	denitrification pathway
GPW72_RS06825	COG0243	molybdopterin cofactor binding
GPW72_RS06845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW72_RS06860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPW72_RS06895	COG4589	Belongs to the CDS family
GPW72_RS06905	COG5001	Diguanylate cyclase
GPW72_RS06905	COG3300	MHYT domain
GPW72_RS06920	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPW72_RS06925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW72_RS06930	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW72_RS06935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW72_RS06945	COG4191	Histidine kinase
GPW72_RS06955	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPW72_RS06965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPW72_RS06970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPW72_RS06975	COG0776	regulation of translation
GPW72_RS06980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW72_RS06985	COG1555	photosystem II stabilization
GPW72_RS06990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPW72_RS06995	COG0539	negative regulation of cytoplasmic translation
GPW72_RS07000	COG0776	regulation of translation
GPW72_RS07005	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPW72_RS07010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPW72_RS07015	COG0284	orotidine-5'-phosphate decarboxylase activity
GPW72_RS07030	COG0583	DNA-binding transcription factor activity
GPW72_RS07040	COG0686	Belongs to the AlaDH PNT family
GPW72_RS07055	COG1674	ftsk spoiiie
GPW72_RS07060	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPW72_RS07065	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW72_RS07070	COG2186	Transcriptional regulator
GPW72_RS07085	COG0537	adenosine 5'-monophosphoramidase activity
GPW72_RS07115	COG1252	NADH dehydrogenase
GPW72_RS07135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPW72_RS07145	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW72_RS07150	COG1136	(ABC) transporter
GPW72_RS07155	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW72_RS07170	COG0658	competence protein
GPW72_RS07170	COG2333	competence protein COMEC
GPW72_RS07175	COG1132	(ABC) transporter
GPW72_RS07180	COG1663	tetraacyldisaccharide 4'-kinase activity
GPW72_RS07190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPW72_RS07195	COG2719	SpoVR family
GPW72_RS07200	COG2718	Belongs to the UPF0229 family
GPW72_RS07205	COG2766	serine protein kinase
GPW72_RS07210	COG3013	Belongs to the UPF0304 family
GPW72_RS07220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPW72_RS07225	COG0840	transmembrane signaling receptor activity
GPW72_RS07235	COG1882	Formate acetyltransferase
GPW72_RS07255	COG4215	(ABC) transporter
GPW72_RS07260	COG4160	amino acid transport
GPW72_RS07265	COG0708	Exodeoxyribonuclease III
GPW72_RS07270	COG0840	transmembrane signaling receptor activity
GPW72_RS07280	COG3923	Primosomal replication protein n
GPW72_RS07285	COG0730	response to heat
GPW72_RS07290	COG1199	ATP-dependent helicase activity
GPW72_RS07295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW72_RS07300	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW72_RS07310	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW72_RS07315	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW72_RS07320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW72_RS07325	COG0215	cysteine-tRNA ligase activity
GPW72_RS07330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPW72_RS07335	COG0632	four-way junction helicase activity
GPW72_RS07340	COG2255	four-way junction helicase activity
GPW72_RS07345	COG1271	oxidase subunit
GPW72_RS07350	COG1294	oxidase, subunit
GPW72_RS07355	COG4890	Cyd operon protein YbgT
GPW72_RS07360	COG3790	cyd operon protein YbgE
GPW72_RS07365	COG0824	Thioesterase
GPW72_RS07370	COG0811	peptide transport
GPW72_RS07385	COG0823	Involved in the tonB-independent uptake of proteins
GPW72_RS07390	COG2885	chlorophyll binding
GPW72_RS07400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPW72_RS07410	COG5002	protein histidine kinase activity
GPW72_RS07410	COG0784	Response regulator, receiver
GPW72_RS07420	COG1482	cell wall glycoprotein biosynthetic process
GPW72_RS07425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW72_RS07425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW72_RS07425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW72_RS07430	COG2207	Transcriptional regulator
GPW72_RS07440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW72_RS07445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW72_RS07450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW72_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
GPW72_RS07465	COG3284	Transcriptional regulator
GPW72_RS07470	COG4628	conserved protein (DUF2132)
GPW72_RS07480	COG0415	Belongs to the DNA photolyase family
GPW72_RS07560	COG0488	(ABC) transporter
GPW72_RS07600	COG3941	tape measure
GPW72_RS07615	COG2003	Belongs to the UPF0758 family
GPW72_RS07625	COG4409	exo-alpha-(2->6)-sialidase activity
GPW72_RS07630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW72_RS07635	COG1940	carbohydrate kinase activity
GPW72_RS07640	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPW72_RS07650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW72_RS07655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW72_RS07660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW72_RS07665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPW72_RS07670	COG1737	Transcriptional regulator
GPW72_RS07675	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW72_RS07680	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPW72_RS07700	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPW72_RS07720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPW72_RS07740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPW72_RS07745	COG0582	viral genome integration into host DNA
GPW72_RS07750	COG0582	viral genome integration into host DNA
GPW72_RS07765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW72_RS07775	COG3008	intermembrane lipid transfer
GPW72_RS07775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW72_RS07780	COG2995	paraquat-inducible protein a
GPW72_RS07785	COG0668	transmembrane transport
GPW72_RS07805	COG1309	transcriptional regulator
GPW72_RS07810	COG1012	belongs to the aldehyde dehydrogenase family
GPW72_RS07835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW72_RS07840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPW72_RS07845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPW72_RS07850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPW72_RS07860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPW72_RS07870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW72_RS07875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW72_RS07880	COG0297	glycogen (starch) synthase activity
GPW72_RS07900	COG3070	regulator of competence-specific genes
GPW72_RS07905	COG1609	Transcriptional regulator
GPW72_RS07915	COG0745	RESPONSE REGULATOR receiver
GPW72_RS07920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW72_RS07925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW72_RS07930	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPW72_RS07935	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPW72_RS07940	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPW72_RS07955	COG1032	radical SAM domain protein
GPW72_RS07960	COG5001	Diguanylate cyclase
GPW72_RS07965	COG0612	Peptidase, M16
GPW72_RS07980	COG0583	DNA-binding transcription factor activity
GPW72_RS07985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPW72_RS07995	COG2350	Protein conserved in bacteria
GPW72_RS08000	COG1607	acyl-coa hydrolase
GPW72_RS08005	COG2917	probably involved in intracellular septation
GPW72_RS08015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW72_RS08020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW72_RS08030	COG2116	formate transmembrane transporter activity
GPW72_RS08040	COG4459	periplasmic nitrate reductase
GPW72_RS08045	COG3005	denitrification pathway
GPW72_RS08050	COG0243	molybdopterin cofactor binding
GPW72_RS08070	COG1227	inorganic diphosphatase activity
GPW72_RS08085	COG4172	Belongs to the ABC transporter superfamily
GPW72_RS08095	COG4171	peptide transport system, permease
GPW72_RS08100	COG4168	peptide transport system, permease
GPW72_RS08110	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPW72_RS08115	COG1842	Phage shock protein A
GPW72_RS08130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW72_RS08145	COG2818	Glycosylase
GPW72_RS08150	COG0626	cystathionine gamma-synthase activity
GPW72_RS08160	COG0733	neurotransmitter:sodium symporter activity
GPW72_RS08165	COG0564	pseudouridine synthase activity
GPW72_RS08170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPW72_RS08175	COG4136	ATPase activity
GPW72_RS08180	COG4135	transport system, permease component
GPW72_RS08185	COG4134	Bacterial extracellular solute-binding protein
GPW72_RS08195	COG3313	Fe-S protein
GPW72_RS08205	COG0842	Transport permease protein
GPW72_RS08210	COG1131	(ABC) transporter
GPW72_RS08215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW72_RS08220	COG0814	amino acid
GPW72_RS08230	COG2239	Acts as a magnesium transporter
GPW72_RS08250	COG4934	collagen metabolic process
GPW72_RS08280	COG0840	transmembrane signaling receptor activity
GPW72_RS08290	COG3706	GGDEF domain
GPW72_RS08290	COG4251	negative regulation of phosphorylation
GPW72_RS08290	COG2203	Gaf domain
GPW72_RS08290	COG5001	Diguanylate cyclase
GPW72_RS08295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPW72_RS08315	COG1061	Type III restriction enzyme res subunit
GPW72_RS08320	COG1187	pseudouridine synthase activity
GPW72_RS08325	COG2814	Major facilitator Superfamily
GPW72_RS08335	COG0702	epimerase
GPW72_RS08340	COG0534	Mate efflux family protein
GPW72_RS08345	COG4181	ATPase activity
GPW72_RS08360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW72_RS08370	COG1748	Saccharopine dehydrogenase
GPW72_RS08375	COG0019	diaminopimelate decarboxylase activity
GPW72_RS08385	COG1538	Outer membrane efflux protein
GPW72_RS08405	COG0583	DNA-binding transcription factor activity
GPW72_RS08415	COG1451	nucleotide metabolic process
GPW72_RS08430	COG3063	Type IV pilus biogenesis stability protein PilW
GPW72_RS08435	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPW72_RS08455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW72_RS08470	COG3290	protein histidine kinase activity
GPW72_RS08475	COG4565	transcriptional regulatory protein
GPW72_RS08485	COG0835	chemotaxis
GPW72_RS08485	COG0784	Response regulator, receiver
GPW72_RS08505	COG3706	GGDEF domain
GPW72_RS08505	COG0745	RESPONSE REGULATOR receiver
GPW72_RS08530	COG1085	galactose-1-phosphate uridylyltransferase
GPW72_RS08535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPW72_RS08540	COG2017	converts alpha-aldose to the beta-anomer
GPW72_RS08545	COG3706	GGDEF domain
GPW72_RS08550	COG2200	EAL domain
GPW72_RS08550	COG2199	diguanylate cyclase activity
GPW72_RS08565	COG3527	Alpha-acetolactate decarboxylase
GPW72_RS08580	COG0753	catalase activity
GPW72_RS08600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW72_RS08610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPW72_RS08650	COG1271	oxidase subunit
GPW72_RS08655	COG1294	oxidase, subunit
GPW72_RS08660	COG1136	(ABC) transporter
GPW72_RS08660	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW72_RS08665	COG0577	efflux transmembrane transporter activity
GPW72_RS08665	COG1136	(ABC) transporter
GPW72_RS08670	COG1136	(ABC) transporter
GPW72_RS08670	COG0577	efflux transmembrane transporter activity
GPW72_RS08690	COG0583	DNA-binding transcription factor activity
GPW72_RS08695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPW72_RS08700	COG2723	6-phospho-beta-galactosidase activity
GPW72_RS08705	COG1609	Transcriptional regulator
GPW72_RS08710	COG0251	oxidation-reduction process
GPW72_RS08715	COG2731	YhcH YjgK YiaL family protein
GPW72_RS08720	COG0584	glycerophosphoryl diester phosphodiesterase
GPW72_RS08725	COG1349	DNA-binding transcription factor activity
GPW72_RS08730	COG3842	ATPase activity
GPW72_RS08735	COG0395	ABC-type sugar transport system, permease component
GPW72_RS08740	COG1175	transmembrane transport
GPW72_RS08755	COG0811	peptide transport
GPW72_RS08760	COG0811	peptide transport
GPW72_RS08765	COG0848	biopolymer transport protein
GPW72_RS08770	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW72_RS08780	COG1793	dna ligase
GPW72_RS08790	COG0534	Mate efflux family protein
GPW72_RS08810	COG0791	NLP P60 protein
GPW72_RS08815	COG0840	transmembrane signaling receptor activity
GPW72_RS08830	COG1940	carbohydrate kinase activity
GPW72_RS08860	COG0746	molybdenum cofactor guanylyltransferase activity
GPW72_RS08865	COG3842	ATPase activity
GPW72_RS08870	COG4662	Binding-protein-dependent transport system inner membrane component
GPW72_RS08880	COG2204	response regulator
GPW72_RS08885	COG3852	Histidine kinase
GPW72_RS08890	COG0488	(ABC) transporter
GPW72_RS08895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPW72_RS08925	COG0243	molybdopterin cofactor binding
GPW72_RS08925	COG3383	formate dehydrogenase (NAD+) activity
GPW72_RS08930	COG0437	4 iron, 4 sulfur cluster binding
GPW72_RS08945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPW72_RS08955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW72_RS08970	COG2996	Protein conserved in bacteria
GPW72_RS08975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW72_RS08975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPW72_RS08980	COG3008	intermembrane lipid transfer
GPW72_RS08985	COG2995	paraquat-inducible protein a
GPW72_RS08990	COG1132	(ABC) transporter
GPW72_RS08995	COG1956	GAF domain-containing protein
GPW72_RS09000	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPW72_RS09015	COG0308	aminopeptidase N
GPW72_RS09030	COG0167	dihydroorotate dehydrogenase activity
GPW72_RS09040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW72_RS09040	COG0116	Belongs to the methyltransferase superfamily
GPW72_RS09065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW72_RS09070	COG1067	ATP-dependent peptidase activity
GPW72_RS09075	COG3120	sequence-specific DNA binding
GPW72_RS09165	COG4128	Pfam Zonular occludens toxin
GPW72_RS09210	COG4128	Pfam Zonular occludens toxin
GPW72_RS09245	COG3064	Membrane
GPW72_RS09245	COG1073	alpha beta
GPW72_RS09245	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPW72_RS09250	COG2994	toxin metabolic process
GPW72_RS09275	COG2205	protein histidine kinase activity
GPW72_RS09275	COG0784	Response regulator, receiver
GPW72_RS09290	COG3278	Belongs to the heme-copper respiratory oxidase family
GPW72_RS09305	COG2010	Cytochrome c
GPW72_RS09315	COG2217	Heavy metal translocating P-type atpase
GPW72_RS09330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW72_RS09335	COG0589	response to stress
GPW72_RS09340	COG0037	tRNA processing
GPW72_RS09360	COG3842	ATPase activity
GPW72_RS09365	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPW72_RS09370	COG1177	transmembrane transport
GPW72_RS09375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW72_RS09380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW72_RS09395	COG1115	amino acid carrier protein
GPW72_RS09400	COG1280	lysine exporter protein (LysE YggA)
GPW72_RS09435	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPW72_RS09440	COG0840	transmembrane signaling receptor activity
GPW72_RS09445	COG2814	Major facilitator Superfamily
GPW72_RS09455	COG1538	Outer membrane efflux protein
GPW72_RS09465	COG0513	Belongs to the DEAD box helicase family
GPW72_RS09475	COG0840	transmembrane signaling receptor activity
GPW72_RS09480	COG3290	protein histidine kinase activity
GPW72_RS09480	COG0840	transmembrane signaling receptor activity
GPW72_RS09485	COG0835	chemotaxis
GPW72_RS09490	COG2201	protein-glutamate methylesterase activity
GPW72_RS09500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW72_RS09510	COG0643	Histidine kinase
GPW72_RS09510	COG2198	Histidine kinase
GPW72_RS09530	COG2076	Multidrug Resistance protein
GPW72_RS09535	COG0415	Belongs to the DNA photolyase family
GPW72_RS09540	COG0477	Major facilitator Superfamily
GPW72_RS09545	COG0583	DNA-binding transcription factor activity
GPW72_RS09555	COG0095	Lipoate-protein ligase
GPW72_RS09560	COG0443	Heat shock 70 kDa protein
GPW72_RS09570	COG1643	Atp-dependent helicase
GPW72_RS09605	COG0443	Heat shock 70 kDa protein
GPW72_RS09610	COG0443	Heat shock 70 kDa protein
GPW72_RS09615	COG3706	GGDEF domain
GPW72_RS09645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPW72_RS09650	COG0602	queuosine metabolic process
GPW72_RS09655	COG0561	phosphatase activity
GPW72_RS09665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW72_RS09670	COG4597	amino acid ABC transporter
GPW72_RS09675	COG0765	amino acid transport
GPW72_RS09680	COG1126	abc transporter atp-binding protein
GPW72_RS09685	COG0670	Belongs to the BI1 family
GPW72_RS09690	COG2920	part of a sulfur-relay system
GPW72_RS09695	COG1254	Belongs to the acylphosphatase family
GPW72_RS09705	COG3706	GGDEF domain
GPW72_RS09720	COG3437	response regulator, receiver
GPW72_RS09725	COG0625	glutathione transferase activity
GPW72_RS09735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPW72_RS09745	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW72_RS09775	COG0372	Belongs to the citrate synthase family
GPW72_RS09780	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPW72_RS09785	COG2186	Transcriptional regulator
GPW72_RS09820	COG1129	ABC transporter
GPW72_RS09845	COG0745	RESPONSE REGULATOR receiver
GPW72_RS09850	COG2205	protein histidine kinase activity
GPW72_RS09855	COG3713	MltA-interacting MipA family protein
GPW72_RS09860	COG2990	Protein conserved in bacteria
GPW72_RS09870	COG4191	Histidine kinase
GPW72_RS09870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW72_RS09875	COG0471	metal ion transport
GPW72_RS09885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW72_RS09900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW72_RS09905	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPW72_RS09910	COG3768	UPF0283 membrane protein
GPW72_RS09915	COG3106	COG3106 Predicted ATPase
GPW72_RS09930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW72_RS09935	COG0494	nUDIX hydrolase
GPW72_RS09940	COG0814	amino acid
GPW72_RS09945	COG1760	l-serine dehydratase
GPW72_RS09950	COG0720	synthase
GPW72_RS09960	COG0017	Asparaginyl-tRNA synthetase
GPW72_RS09965	COG0351	phosphomethylpyrimidine kinase
GPW72_RS09970	COG2770	Histidine kinase
GPW72_RS09970	COG3437	response regulator, receiver
GPW72_RS09980	COG1448	Aminotransferase
GPW72_RS09995	COG0840	transmembrane signaling receptor activity
GPW72_RS10000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPW72_RS10005	COG2943	transferase activity, transferring hexosyl groups
GPW72_RS10010	COG1609	Transcriptional regulator
GPW72_RS10015	COG3394	polysaccharide catabolic process
GPW72_RS10020	COG1486	melibiose metabolic process
GPW72_RS10025	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPW72_RS10035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPW72_RS10040	COG0726	polysaccharide deacetylase
GPW72_RS10045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPW72_RS10050	COG1846	Transcriptional regulator
GPW72_RS10075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW72_RS10090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW72_RS10095	COG3108	Peptidase M15
GPW72_RS10100	COG2989	Protein conserved in bacteria
GPW72_RS10125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW72_RS10135	COG2814	Major facilitator Superfamily
GPW72_RS10155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW72_RS10160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW72_RS10165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW72_RS10210	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPW72_RS10215	COG4139	cobalamin transport
GPW72_RS10220	COG2988	succinylglutamate desuccinylase activity
GPW72_RS10235	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPW72_RS10240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPW72_RS10245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW72_RS10255	COG2925	Exonuclease
GPW72_RS10265	COG1346	cytolysis
GPW72_RS10270	COG0295	cytidine deaminase activity
GPW72_RS10290	COG0500	methyltransferase
GPW72_RS10305	COG0776	regulation of translation
GPW72_RS10310	COG0072	phenylalanine-tRNA ligase activity
GPW72_RS10310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW72_RS10315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPW72_RS10325	COG3706	GGDEF domain
GPW72_RS10325	COG0745	RESPONSE REGULATOR receiver
GPW72_RS10355	COG0322	excinuclease ABC activity
GPW72_RS10360	COG2197	response regulator
GPW72_RS10365	COG0417	DNA replication proofreading
GPW72_RS10370	COG5001	Diguanylate cyclase
GPW72_RS10380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW72_RS10400	COG1228	amidohydrolase
GPW72_RS10405	COG0010	Belongs to the arginase family
GPW72_RS10410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPW72_RS10415	COG2986	histidine ammonia-lyase
GPW72_RS10435	COG0247	lactate metabolic process
GPW72_RS10435	COG0277	FAD linked oxidase domain protein
GPW72_RS10450	COG2885	chlorophyll binding
GPW72_RS10470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPW72_RS10480	COG0281	malic enzyme
GPW72_RS10490	COG2949	membrane
GPW72_RS10495	COG3706	GGDEF domain
GPW72_RS10500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW72_RS10510	COG0492	ferredoxin-NADP+ reductase activity
GPW72_RS10515	COG4988	ABC transporter
GPW72_RS10520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPW72_RS10525	COG1187	pseudouridine synthase activity
GPW72_RS10530	COG0009	L-threonylcarbamoyladenylate synthase
GPW72_RS10535	COG0613	PHP domain protein
GPW72_RS10545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW72_RS10550	COG0512	Glutamine amidotransferase of anthranilate synthase
GPW72_RS10555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPW72_RS10560	COG0134	indole-3-glycerol-phosphate synthase activity
GPW72_RS10560	COG0135	phosphoribosylanthranilate isomerase activity
GPW72_RS10565	COG0133	tryptophan synthase activity
GPW72_RS10570	COG0159	tryptophan synthase activity
GPW72_RS10580	COG1435	thymidine kinase activity
GPW72_RS10585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPW72_RS10590	COG1801	Protein of unknown function DUF72
GPW72_RS10595	COG4106	trans-aconitate 2-methyltransferase activity
GPW72_RS10600	COG0500	methyltransferase
GPW72_RS10605	COG0189	ligase activity
GPW72_RS10605	COG4067	protein conserved in archaea
GPW72_RS10620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPW72_RS10630	COG3852	Histidine kinase
GPW72_RS10645	COG3070	regulator of competence-specific genes
GPW72_RS10655	COG2431	L-lysine efflux transmembrane transporter activity
GPW72_RS10665	COG0076	glutamate decarboxylase activity
GPW72_RS10670	COG1737	Transcriptional regulator
GPW72_RS10675	COG1454	alcohol dehydrogenase
GPW72_RS10675	COG1012	belongs to the aldehyde dehydrogenase family
GPW72_RS10680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW72_RS10690	COG0542	response to heat
GPW72_RS10695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPW72_RS10700	COG1278	Cold shock
GPW72_RS10710	COG1187	pseudouridine synthase activity
GPW72_RS10715	COG0140	phosphoribosyl-ATP diphosphatase activity
GPW72_RS10715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPW72_RS10720	COG0107	imidazoleglycerol-phosphate synthase activity
GPW72_RS10725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPW72_RS10730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPW72_RS10735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW72_RS10735	COG0131	Imidazoleglycerol-phosphate dehydratase
GPW72_RS10740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPW72_RS10745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPW72_RS10750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPW72_RS10755	COG1757	Na H antiporter
GPW72_RS10760	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPW72_RS10765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW72_RS10770	COG0482	sulfurtransferase activity
GPW72_RS10775	COG2915	High frequency lysogenization protein hflD homolog
GPW72_RS10780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPW72_RS10790	COG2268	Band 7 protein
GPW72_RS10800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPW72_RS10815	COG0300	oxidoreductase activity
GPW72_RS10825	COG0501	Belongs to the peptidase M48B family
GPW72_RS10835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPW72_RS10840	COG2226	methyltransferase
GPW72_RS10845	COG0156	8-amino-7-oxononanoate synthase activity
GPW72_RS10850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW72_RS10855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPW72_RS10860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPW72_RS10865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPW72_RS10870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPW72_RS10880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW72_RS10885	COG2203	Gaf domain
GPW72_RS10885	COG2199	diguanylate cyclase activity
GPW72_RS10895	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPW72_RS10905	COG4628	conserved protein (DUF2132)
GPW72_RS10910	COG3092	negative regulation of chromosome organization
GPW72_RS10915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW72_RS10920	COG0280	phosphate acetyltransferase
GPW72_RS10920	COG0857	belongs to the CobB CobQ family
GPW72_RS10925	COG0435	Glutathione S-transferase
GPW72_RS10930	COG4608	Belongs to the ABC transporter superfamily
GPW72_RS10935	COG0444	Belongs to the ABC transporter superfamily
GPW72_RS10940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW72_RS10945	COG0601	transmembrane transport
GPW72_RS10965	COG2204	response regulator
GPW72_RS10970	COG5001	Diguanylate cyclase
GPW72_RS10970	COG3300	MHYT domain
GPW72_RS10975	COG4191	Histidine kinase
GPW72_RS10980	COG5002	protein histidine kinase activity
GPW72_RS10990	COG2201	protein-glutamate methylesterase activity
GPW72_RS11005	COG0009	L-threonylcarbamoyladenylate synthase
GPW72_RS11025	COG1881	PFAM PEBP family protein
GPW72_RS11050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW72_RS11055	COG0640	Transcriptional regulator
GPW72_RS11065	COG3706	GGDEF domain
GPW72_RS11085	COG1946	Acyl-CoA thioesterase
GPW72_RS11090	COG1522	sequence-specific DNA binding
GPW72_RS11100	COG0616	signal peptide processing
GPW72_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
GPW72_RS11120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPW72_RS11125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPW72_RS11135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPW72_RS11140	COG2832	Protein of unknown function (DUF454)
GPW72_RS11150	COG0745	RESPONSE REGULATOR receiver
GPW72_RS11155	COG0583	DNA-binding transcription factor activity
GPW72_RS11160	COG0778	Nitroreductase
GPW72_RS11165	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW72_RS11165	COG1024	Enoyl-CoA hydratase
GPW72_RS11170	COG0183	Belongs to the thiolase family
GPW72_RS11185	COG2067	long-chain fatty acid transport protein
GPW72_RS11195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW72_RS11200	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPW72_RS11205	COG2982	Protein involved in outer membrane biogenesis
GPW72_RS11210	COG0572	uridine kinase
GPW72_RS11215	COG0489	protein tyrosine kinase activity
GPW72_RS11220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW72_RS11220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW72_RS11230	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPW72_RS11240	COG4109	DRTGG domain
GPW72_RS11245	COG2199	diguanylate cyclase activity
GPW72_RS11250	COG0314	molybdopterin synthase activity
GPW72_RS11255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPW72_RS11260	COG0315	cyclic pyranopterin monophosphate synthase activity
GPW72_RS11265	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPW72_RS11270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPW72_RS11275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPW72_RS11280	COG2198	Histidine kinase
GPW72_RS11285	COG2204	response regulator
GPW72_RS11290	COG0556	nucleotide-excision repair
GPW72_RS11300	COG4657	Part of a membrane complex involved in electron transport
GPW72_RS11305	COG2878	Part of a membrane complex involved in electron transport
GPW72_RS11310	COG4656	Part of a membrane complex involved in electron transport
GPW72_RS11315	COG4658	electron transport chain
GPW72_RS11320	COG4659	FMN binding
GPW72_RS11325	COG4660	Part of a membrane complex involved in electron transport
GPW72_RS11330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPW72_RS11335	COG0346	lactoylglutathione lyase activity
GPW72_RS11350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW72_RS11355	COG2056	Na+-H+ antiporter family
GPW72_RS11360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPW72_RS11365	COG1286	toxin biosynthetic process
GPW72_RS11370	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPW72_RS11375	COG0285	dihydrofolate synthase activity
GPW72_RS11380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPW72_RS11385	COG0101	tRNA pseudouridine synthase activity
GPW72_RS11395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW72_RS11400	COG2190	(PTS) system
GPW72_RS11400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW72_RS11400	COG1263	PTS System
GPW72_RS11405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW72_RS11410	COG1846	Transcriptional regulator
GPW72_RS11410	COG1940	carbohydrate kinase activity
GPW72_RS11415	COG4651	solute:proton antiporter activity
GPW72_RS11415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW72_RS11420	COG0367	asparagine synthase
GPW72_RS11435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPW72_RS11440	COG0563	adenylate kinase activity
GPW72_RS11445	COG0326	Molecular chaperone. Has ATPase activity
GPW72_RS11450	COG3710	Transcriptional regulator
GPW72_RS11465	COG0622	Phosphoesterase
GPW72_RS11470	COG1090	epimerase
GPW72_RS11475	COG0300	oxidoreductase activity
GPW72_RS11485	COG3118	belongs to the thioredoxin family
GPW72_RS11490	COG0330	HflC and HflK could
GPW72_RS11495	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPW72_RS11500	COG0789	Transcriptional regulator
GPW72_RS11515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPW72_RS11520	COG3115	cell septum assembly
GPW72_RS11525	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPW72_RS11530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPW72_RS11540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW72_RS11550	COG2190	(PTS) system
GPW72_RS11555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW72_RS11560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW72_RS11565	COG1702	phosphate starvation-inducible protein PhoH
GPW72_RS11570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPW72_RS11575	COG4535	Mg2 and Co2 transporter CorC
GPW72_RS11580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPW72_RS11585	COG2888	peptidyl-tyrosine sulfation
GPW72_RS11590	COG0495	leucyl-tRNA aminoacylation
GPW72_RS11595	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPW72_RS11600	COG1466	dna polymerase III delta subunit
GPW72_RS11605	COG0799	negative regulation of ribosome biogenesis
GPW72_RS11610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPW72_RS11620	COG0772	Belongs to the SEDS family
GPW72_RS11625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW72_RS11630	COG1686	Belongs to the peptidase S11 family
GPW72_RS11635	COG2921	Belongs to the UPF0250 family
GPW72_RS11640	COG0321	lipoyl(octanoyl) transferase activity
GPW72_RS11645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPW72_RS11655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW72_RS11680	COG1596	polysaccharide export
GPW72_RS11690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW72_RS11720	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPW72_RS11730	COG0438	transferase activity, transferring glycosyl groups
GPW72_RS11740	COG1045	serine acetyltransferase
GPW72_RS11760	COG0110	maltose O-acetyltransferase activity
GPW72_RS11765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPW72_RS11770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPW72_RS11775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW72_RS11780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW72_RS11810	COG0366	Alpha amylase catalytic
GPW72_RS11815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW72_RS11815	COG1263	PTS System
GPW72_RS11820	COG1609	Transcriptional regulator
GPW72_RS11825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW72_RS11830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPW72_RS11835	COG2011	ABC-type metal ion transport system permease component
GPW72_RS11840	COG1464	Belongs to the NlpA lipoprotein family
GPW72_RS11845	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPW72_RS11855	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW72_RS11855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW72_RS11865	COG3706	GGDEF domain
GPW72_RS11870	COG1611	Belongs to the LOG family
GPW72_RS11875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW72_RS11880	COG2363	Small membrane protein
GPW72_RS11885	COG0583	DNA-binding transcription factor activity
GPW72_RS11890	COG0301	tRNA thio-modification
GPW72_RS11890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW72_RS11900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPW72_RS11905	COG1722	exodeoxyribonuclease VII activity
GPW72_RS11910	COG0142	geranyltranstransferase activity
GPW72_RS11915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPW72_RS11920	COG0564	pseudouridine synthase activity
GPW72_RS11925	COG3098	single-species biofilm formation
GPW72_RS11940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW72_RS11950	COG1671	Belongs to the UPF0178 family
GPW72_RS11955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW72_RS11960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPW72_RS11965	COG0254	rRNA binding
GPW72_RS11970	COG1720	tRNA m6t6A37 methyltransferase activity
GPW72_RS11975	COG0442	prolyl-tRNA aminoacylation
GPW72_RS11995	COG1943	Transposase
GPW72_RS12000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPW72_RS12000	COG0047	phosphoribosylformylglycinamidine synthase activity
GPW72_RS12010	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPW72_RS12015	COG0590	tRNA wobble adenosine to inosine editing
GPW72_RS12020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW72_RS12045	COG4968	Prepilin-type N-terminal cleavage methylation domain
GPW72_RS12055	COG0484	heat shock protein binding
GPW72_RS12060	COG0443	Heat shock 70 kDa protein
GPW72_RS12065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPW72_RS12070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPW72_RS12075	COG0497	DNA recombination
GPW72_RS12080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW72_RS12085	COG2914	Belongs to the UPF0125 (RnfH) family
GPW72_RS12090	COG2867	negative regulation of translational initiation
GPW72_RS12095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPW72_RS12105	COG0582	viral genome integration into host DNA
GPW72_RS12115	COG0582	viral genome integration into host DNA
GPW72_RS12120	COG3064	Membrane
GPW72_RS12130	COG0739	heme binding
GPW72_RS12150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GPW72_RS12155	COG2207	Transcriptional regulator
GPW72_RS12165	COG1459	type II secretion system
GPW72_RS12170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW72_RS12190	COG4796	Type ii and iii secretion system protein
GPW72_RS12205	COG2165	general secretion pathway protein
GPW72_RS12215	COG3710	Transcriptional regulator
GPW72_RS12220	COG0840	transmembrane signaling receptor activity
GPW72_RS12225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GPW72_RS12245	COG1012	belongs to the aldehyde dehydrogenase family
GPW72_RS12310	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPW72_RS12315	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPW72_RS12320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW72_RS12330	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPW72_RS12335	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPW72_RS12340	COG3051	citrate lyase alpha subunit
GPW72_RS12345	COG2301	Belongs to the HpcH HpaI aldolase family
GPW72_RS12350	COG3052	prosthetic group binding
GPW72_RS12355	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPW72_RS12365	COG3630	sodium ion export across plasma membrane
GPW72_RS12370	COG0511	ligase activity, forming carbon-carbon bonds
GPW72_RS12370	COG5016	pyruvate
GPW72_RS12375	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW72_RS12385	COG4565	transcriptional regulatory protein
GPW72_RS12400	COG0583	DNA-binding transcription factor activity
GPW72_RS12405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW72_RS12410	COG1115	amino acid carrier protein
GPW72_RS12415	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPW72_RS12420	COG0583	DNA-binding transcription factor activity
GPW72_RS12430	COG1120	ATPase activity
GPW72_RS12435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW72_RS12440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW72_RS12445	COG4592	Periplasmic binding protein
GPW72_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
GPW72_RS12460	COG1169	isochorismate synthase
GPW72_RS12465	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPW72_RS12470	COG1535	isochorismatase
GPW72_RS12470	COG3433	isochorismatase activity
GPW72_RS12475	COG1584	GPR1 FUN34 yaaH family protein
GPW72_RS12485	COG0519	Catalyzes the synthesis of GMP from XMP
GPW72_RS12485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPW72_RS12490	COG0516	GMP reductase activity
GPW72_RS12490	COG0517	IMP dehydrogenase activity
GPW72_RS12495	COG1570	exodeoxyribonuclease VII activity
GPW72_RS12510	COG1160	GTP binding
GPW72_RS12515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW72_RS12520	COG2976	Protein conserved in bacteria
GPW72_RS12525	COG0124	histidyl-tRNA synthetase
GPW72_RS12530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPW72_RS12540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPW72_RS12545	COG0105	UTP biosynthetic process
GPW72_RS12550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW72_RS12555	COG2975	iron-sulfur cluster assembly
GPW72_RS12560	COG0633	Ferredoxin
GPW72_RS12565	COG0443	Heat shock 70 kDa protein
GPW72_RS12570	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW72_RS12580	COG0822	iron-sulfur transferase activity
GPW72_RS12585	COG1104	cysteine desulfurase activity
GPW72_RS12590	COG1959	2 iron, 2 sulfur cluster binding
GPW72_RS12600	COG0483	inositol monophosphate 1-phosphatase activity
GPW72_RS12605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW72_RS12610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW72_RS12615	COG1862	Preprotein translocase
GPW72_RS12620	COG0343	queuine tRNA-ribosyltransferase activity
GPW72_RS12625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPW72_RS12630	COG0517	IMP dehydrogenase activity
GPW72_RS12640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPW72_RS12645	COG0583	DNA-binding transcription factor activity
GPW72_RS12650	COG0450	alkyl hydroperoxide reductase
GPW72_RS12655	COG3142	Participates in the control of copper homeostasis
GPW72_RS12670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW72_RS12675	COG0581	inorganic phosphate transmembrane transporter activity
GPW72_RS12685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPW72_RS12690	COG0248	Ppx GppA phosphatase
GPW72_RS12700	COG5002	protein histidine kinase activity
GPW72_RS12705	COG0745	RESPONSE REGULATOR receiver
GPW72_RS12710	COG2974	May be involved in recombination
GPW72_RS12720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW72_RS12760	COG0542	response to heat
GPW72_RS12770	COG0564	pseudouridine synthase activity
GPW72_RS12775	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW72_RS12780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW72_RS12785	COG0077	Prephenate dehydratase
GPW72_RS12785	COG1605	Chorismate mutase
GPW72_RS12790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW72_RS12795	COG5001	Diguanylate cyclase
GPW72_RS12800	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPW72_RS12805	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPW72_RS12815	COG0488	(ABC) transporter
GPW72_RS12825	COG0287	Prephenate dehydrogenase
GPW72_RS12825	COG1605	Chorismate mutase
GPW72_RS12830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW72_RS12835	COG3275	phosphorelay sensor kinase activity
GPW72_RS12840	COG3279	Response regulator of the LytR AlgR family
GPW72_RS12845	COG1472	Belongs to the glycosyl hydrolase 3 family
GPW72_RS12850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPW72_RS12855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW72_RS12870	COG1966	Carbon starvation protein
GPW72_RS12875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPW72_RS12880	COG1047	Peptidyl-prolyl cis-trans
GPW72_RS12885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPW72_RS12890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPW72_RS12895	COG0196	riboflavin kinase activity
GPW72_RS12900	COG0728	peptidoglycan biosynthetic process
GPW72_RS12905	COG0268	Binds directly to 16S ribosomal RNA
GPW72_RS12910	COG0640	Transcriptional regulator
GPW72_RS12915	COG0583	DNA-binding transcription factor activity
GPW72_RS12920	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPW72_RS12925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPW72_RS12930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPW72_RS12935	COG0730	response to heat
GPW72_RS12940	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPW72_RS12945	COG0494	nUDIX hydrolase
GPW72_RS12950	COG3066	DNA modification
GPW72_RS12955	COG0667	Aldo Keto reductase
GPW72_RS12970	COG2204	response regulator
GPW72_RS12975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPW72_RS12990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPW72_RS12995	COG0513	Belongs to the DEAD box helicase family
GPW72_RS13000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPW72_RS13020	COG3153	acetyltransferase
GPW72_RS13055	COG4785	May be involved in cell division
GPW72_RS13060	COG1185	polyribonucleotide nucleotidyltransferase activity
GPW72_RS13065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPW72_RS13070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPW72_RS13075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPW72_RS13080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPW72_RS13085	COG0195	Participates in both transcription termination and antitermination
GPW72_RS13090	COG0779	Required for maturation of 30S ribosomal subunits
GPW72_RS13105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW72_RS13110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW72_RS13115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPW72_RS13120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPW72_RS13125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPW72_RS13130	COG1534	Rna-binding protein
GPW72_RS13135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW72_RS13140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW72_RS13150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW72_RS13155	COG0739	heme binding
GPW72_RS13170	COG0316	Belongs to the HesB IscA family
GPW72_RS13175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPW72_RS13185	COG0628	permease
GPW72_RS13190	COG2813	Specifically methylates the guanine in position
GPW72_RS13200	COG0747	negative chemotaxis
GPW72_RS13205	COG0601	transmembrane transport
GPW72_RS13210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW72_RS13215	COG0444	Belongs to the ABC transporter superfamily
GPW72_RS13220	COG4608	Belongs to the ABC transporter superfamily
GPW72_RS13230	COG2971	BadF BadG BcrA BcrD
GPW72_RS13250	COG3842	ATPase activity
GPW72_RS13260	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW72_RS13265	COG0004	ammonium transporteR
GPW72_RS13270	COG0347	Belongs to the P(II) protein family
GPW72_RS13275	COG3112	Uncharacterised protein family (UPF0231)
GPW72_RS13280	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPW72_RS13290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPW72_RS13295	COG1643	Atp-dependent helicase
GPW72_RS13305	COG1489	DNA binding
GPW72_RS13310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPW72_RS13315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW72_RS13325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW72_RS13330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPW72_RS13335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPW72_RS13340	COG0842	Transport permease protein
GPW72_RS13345	COG1131	(ABC) transporter
GPW72_RS13350	COG0659	secondary active sulfate transmembrane transporter activity
GPW72_RS13355	COG0288	reversible hydration of carbon dioxide
GPW72_RS13370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPW72_RS13375	COG3107	peptidoglycan biosynthetic process
GPW72_RS13380	COG0792	nuclease activity
GPW72_RS13385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW72_RS13390	COG2823	Periplasmic or secreted lipoprotein
GPW72_RS13395	COG2969	positive regulation of protein catabolic process
GPW72_RS13400	COG0625	glutathione transferase activity
GPW72_RS13405	COG2857	Cytochrome c1
GPW72_RS13410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPW72_RS13415	COG0723	plastoquinol--plastocyanin reductase activity
GPW72_RS13420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPW72_RS13425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPW72_RS13430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPW72_RS13440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW72_RS13445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW72_RS13450	COG0335	large ribosomal subunit rRNA binding
GPW72_RS13455	COG0336	Belongs to the RNA methyltransferase TrmD family
GPW72_RS13460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPW72_RS13465	COG0228	four-way junction DNA binding
GPW72_RS13470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPW72_RS13475	COG4137	Cytochrome C assembly protein
GPW72_RS13480	COG4536	flavin adenine dinucleotide binding
GPW72_RS13485	COG1854	S-ribosylhomocysteine lyase activity
GPW72_RS13490	COG2918	glutathione biosynthetic process
GPW72_RS13495	COG0612	Peptidase, M16
GPW72_RS13500	COG1238	metal cluster binding
GPW72_RS13510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW72_RS13515	COG0511	ligase activity, forming carbon-carbon bonds
GPW72_RS13515	COG5016	pyruvate
GPW72_RS13520	COG3630	sodium ion export across plasma membrane
GPW72_RS13565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPW72_RS13570	COG0527	aspartate kinase activity
GPW72_RS13575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPW72_RS13580	COG2137	regulation of response to DNA damage stimulus
GPW72_RS13585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPW72_RS13595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPW72_RS13600	COG4208	sulfate ABC transporter
GPW72_RS13620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPW72_RS13625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW72_RS13630	COG1388	LysM domain
GPW72_RS13630	COG4942	peptidase
GPW72_RS13635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPW72_RS13640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPW72_RS13645	COG0585	pseudouridine synthase activity
GPW72_RS13650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPW72_RS13655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPW72_RS13660	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPW72_RS13665	COG1968	undecaprenyl-diphosphatase activity
GPW72_RS13670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW72_RS13675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPW72_RS13680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPW72_RS13690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPW72_RS13695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPW72_RS13700	COG1610	YqeY-like protein
GPW72_RS13705	COG0358	DNA primase activity
GPW72_RS13710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW72_RS13725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW72_RS13730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPW72_RS13735	COG1349	DNA-binding transcription factor activity
GPW72_RS13740	COG0469	pyruvate kinase activity
GPW72_RS13750	COG0583	DNA-binding transcription factor activity
GPW72_RS13755	COG1279	arginine transmembrane transporter activity
GPW72_RS13760	COG0668	transmembrane transport
GPW72_RS13770	COG0191	fructose-bisphosphate aldolase activity
GPW72_RS13775	COG0126	phosphoglycerate kinase activity
GPW72_RS13780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW72_RS13785	COG4771	TonB-dependent receptor
GPW72_RS13790	COG0583	DNA-binding transcription factor activity
GPW72_RS13795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW72_RS13800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPW72_RS13805	COG3091	SprT-like family
GPW72_RS13810	COG2356	endonuclease I
GPW72_RS13815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPW72_RS13820	COG0189	ligase activity
GPW72_RS13825	COG1678	Uncharacterized ACR, COG1678
GPW72_RS13830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPW72_RS13835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW72_RS13855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPW72_RS13860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPW72_RS13865	COG0762	integral membrane protein
GPW72_RS13880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPW72_RS13885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW72_RS13890	COG2066	Belongs to the glutaminase family
GPW72_RS13895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPW72_RS13900	COG1194	a g-specific adenine glycosylase
GPW72_RS13905	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPW72_RS13910	COG0741	lytic transglycosylase activity
GPW72_RS13965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW72_RS13970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPW72_RS13975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW72_RS13980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPW72_RS13985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPW72_RS13990	COG2967	ApaG domain
GPW72_RS13995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPW72_RS14005	COG3610	response to peptide
GPW72_RS14010	COG2966	Psort location CytoplasmicMembrane, score
GPW72_RS14015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPW72_RS14020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPW72_RS14025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPW72_RS14030	COG0142	geranyltranstransferase activity
GPW72_RS14035	COG0531	amino acid
GPW72_RS14040	COG0039	L-malate dehydrogenase activity
GPW72_RS14045	COG1438	arginine binding
GPW72_RS14060	COG0589	response to stress
GPW72_RS14080	COG2235	arginine
GPW72_RS14085	COG0312	modulator of DNA gyrase
GPW72_RS14090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPW72_RS14095	COG3164	Protein of unknown function
GPW72_RS14100	COG1530	ribonuclease E activity
GPW72_RS14105	COG0424	maF-like protein
GPW72_RS14110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPW72_RS14115	COG1792	Involved in formation and maintenance of cell shape
GPW72_RS14120	COG1077	Cell shape determining protein MreB Mrl
GPW72_RS14165	COG1459	type II secretion system
GPW72_RS14170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW72_RS14180	COG3267	Type II secretory pathway component ExeA
GPW72_RS14180	COG3409	Peptidoglycan-binding domain 1 protein
GPW72_RS14205	COG2199	diguanylate cyclase activity
GPW72_RS14205	COG2200	EAL domain
GPW72_RS14210	COG0629	single-stranded DNA binding
GPW72_RS14225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPW72_RS14235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW72_RS14240	COG0527	aspartate kinase activity
GPW72_RS14245	COG0646	methionine synthase
GPW72_RS14245	COG1410	methionine synthase
GPW72_RS14315	COG0175	sulfate reduction
GPW72_RS14320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPW72_RS14325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW72_RS14350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW72_RS14355	COG0735	belongs to the Fur family
GPW72_RS14370	COG0166	Belongs to the GPI family
GPW72_RS14375	COG0432	Pfam Uncharacterised protein family UPF0047
GPW72_RS14380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW72_RS14385	COG0305	Participates in initiation and elongation during chromosome replication
GPW72_RS14395	COG0359	binds to the 23S rRNA
GPW72_RS14400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPW72_RS14405	COG2965	DNA replication, synthesis of RNA primer
GPW72_RS14410	COG0360	Binds together with S18 to 16S ribosomal RNA
GPW72_RS14420	COG2906	2 iron, 2 sulfur cluster binding
GPW72_RS14425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW72_RS14430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW72_RS14435	COG0049	tRNA binding
GPW72_RS14440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPW72_RS14450	COG2923	Belongs to the DsrF TusC family
GPW72_RS14455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPW72_RS14460	COG2964	Protein conserved in bacteria
GPW72_RS14465	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW72_RS14475	COG2900	Belongs to the SlyX family
GPW72_RS14480	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPW72_RS14485	COG0330	HflC and HflK could
GPW72_RS14490	COG0330	HflC and HflK could
GPW72_RS14495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPW72_RS14500	COG1923	regulation of RNA biosynthetic process
GPW72_RS14505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPW72_RS14510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPW72_RS14520	COG0802	atpase or kinase
GPW72_RS14525	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPW72_RS14570	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPW72_RS14575	COG1162	GTPase activity
GPW72_RS14580	COG0688	phosphatidylethanolamine metabolic process
GPW72_RS14585	COG0471	metal ion transport
GPW72_RS14585	COG0490	domain, Protein
GPW72_RS14595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPW72_RS14600	COG4942	peptidase
GPW72_RS14615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPW72_RS14620	COG2816	NAD+ diphosphatase activity
GPW72_RS14625	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPW72_RS14630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPW72_RS14635	COG0085	RNA polymerase activity
GPW72_RS14640	COG0222	ribosome binding
GPW72_RS14645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPW72_RS14650	COG0081	regulation of translation
GPW72_RS14655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPW72_RS14660	COG0250	Participates in transcription elongation, termination and antitermination
GPW72_RS14665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW72_RS14670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW72_RS14695	COG1072	(Pantothenic acid kinase))
GPW72_RS14705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPW72_RS14715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPW72_RS14760	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPW72_RS14770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPW72_RS14775	COG3118	belongs to the thioredoxin family
GPW72_RS14780	COG0513	Belongs to the DEAD box helicase family
GPW72_RS14785	COG0248	Ppx GppA phosphatase
GPW72_RS14790	COG0784	Response regulator, receiver
GPW72_RS14790	COG2205	protein histidine kinase activity
GPW72_RS14795	COG2814	Major facilitator Superfamily
GPW72_RS14815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW72_RS14820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPW72_RS14825	COG0511	ligase activity, forming carbon-carbon bonds
GPW72_RS14830	COG0439	Biotin carboxylase
GPW72_RS14840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW72_RS14845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPW72_RS14850	COG1609	Transcriptional regulator
GPW72_RS14855	COG0129	dihydroxy-acid dehydratase activity
GPW72_RS14860	COG3265	gluconokinase activity
GPW72_RS14870	COG0800	Aldolase
GPW72_RS14885	COG0840	transmembrane signaling receptor activity
GPW72_RS14890	COG1982	Orn Lys Arg decarboxylase major
GPW72_RS14895	COG0531	amino acid
GPW72_RS14900	COG3710	Transcriptional regulator
GPW72_RS14905	COG0789	Transcriptional regulator
GPW72_RS14915	COG0138	bifunctional purine biosynthesis protein purh
GPW72_RS14920	COG0151	Belongs to the GarS family
GPW72_RS14930	COG0776	regulation of translation
GPW72_RS14935	COG1253	flavin adenine dinucleotide binding
GPW72_RS14940	COG1940	carbohydrate kinase activity
GPW72_RS14950	COG3068	Protein conserved in bacteria
GPW72_RS14960	COG1573	uracil-dna glycosylase
GPW72_RS14965	COG0668	transmembrane transport
GPW72_RS14970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPW72_RS14975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW72_RS15025	COG1012	belongs to the aldehyde dehydrogenase family
GPW72_RS15025	COG1454	alcohol dehydrogenase
GPW72_RS15030	COG0318	PFAM AMP-dependent synthetase and ligase
GPW72_RS15060	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPW72_RS15065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW72_RS15070	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GPW72_RS15070	COG0662	Cupin 2, conserved barrel domain protein
GPW72_RS15075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW72_RS15110	COG1519	Transferase
GPW72_RS15140	COG3642	lipopolysaccharide core region biosynthetic process
GPW72_RS15145	COG0859	PFAM glycosyl transferase family 9
GPW72_RS15150	COG0463	Glycosyl transferase, family 2
GPW72_RS15155	COG0859	PFAM glycosyl transferase family 9
GPW72_RS15160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPW72_RS15165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPW72_RS15175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPW72_RS15180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPW72_RS15195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPW72_RS15205	COG1309	transcriptional regulator
GPW72_RS15210	COG1560	Kdo2-lipid A biosynthetic process
GPW72_RS15215	COG1560	Kdo2-lipid A biosynthetic process
GPW72_RS15220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPW72_RS15225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPW72_RS15230	COG1561	YicC-like family, N-terminal region
GPW72_RS15240	COG1263	PTS System
GPW72_RS15240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW72_RS15245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW72_RS15270	COG1120	ATPase activity
GPW72_RS15275	COG4774	siderophore transport
GPW72_RS15280	COG1132	(ABC) transporter
GPW72_RS15295	COG0514	ATP-dependent DNA helicase (RecQ)
GPW72_RS15300	COG2962	Rard protein
GPW72_RS15315	COG1280	lysine exporter protein (LysE YggA)
GPW72_RS15320	COG0210	DNA helicase
GPW72_RS15330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPW72_RS15335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW72_RS15345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW72_RS15355	COG0747	negative chemotaxis
GPW72_RS15410	COG1309	transcriptional regulator
GPW72_RS15415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW72_RS15420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW72_RS15425	COG2960	long-chain fatty acid transporting porin activity
GPW72_RS15430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPW72_RS15435	COG0583	DNA-binding transcription factor activity
GPW72_RS15505	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPW72_RS15510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW72_RS15515	COG1739	Uncharacterized protein family UPF0029
GPW72_RS15520	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW72_RS15520	COG1024	Enoyl-CoA hydratase
GPW72_RS15525	COG0183	Belongs to the thiolase family
GPW72_RS15530	COG0583	DNA-binding transcription factor activity
GPW72_RS15535	COG2814	Major facilitator Superfamily
GPW72_RS15545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPW72_RS15550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPW72_RS15555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPW72_RS15560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPW72_RS15565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPW72_RS15570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPW72_RS15580	COG0356	it plays a direct role in the translocation of protons across the membrane
GPW72_RS15585	COG3312	ion transport
GPW72_RS15590	COG1475	DNA binding
GPW72_RS15595	COG1192	Involved in chromosome partitioning
GPW72_RS15600	COG0357	Ribosomal RNA small subunit methyltransferase G
GPW72_RS15605	COG0445	tRNA wobble uridine modification
GPW72_RS15615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW72_RS15620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPW72_RS15625	COG0706	membrane insertase activity
GPW72_RS15630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPW72_RS15635	COG0594	ribonuclease P activity
GPW72_RS15640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPW72_RS15645	COG1126	abc transporter atp-binding protein
GPW72_RS15660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPW72_RS15665	COG0592	DNA-directed DNA polymerase activity
GPW72_RS15670	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPW72_RS15675	COG0187	DNA topoisomerase II activity
GPW72_RS15690	COG0071	Belongs to the small heat shock protein (HSP20) family
GPW72_RS15695	COG3977	Valine--pyruvate aminotransferase
GPW72_RS15700	COG0751	glycine-tRNA ligase activity
GPW72_RS15705	COG0752	glycyl-tRNA synthetase alpha subunit
GPW72_RS15710	COG2119	membrane
GPW72_RS15720	COG0425	Belongs to the sulfur carrier protein TusA family
GPW72_RS15730	COG0604	alcohol dehydrogenase
GPW72_RS15740	COG0129	dihydroxy-acid dehydratase activity
GPW72_RS15745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW72_RS15760	COG0606	chelatase, subunit chli
GPW72_RS15765	COG0204	Acyl-transferase
GPW72_RS15770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW72_RS15775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPW72_RS15785	COG3084	Protein conserved in bacteria
GPW72_RS15795	COG4326	sporulation control protein
GPW72_RS15800	COG1272	protein, Hemolysin III
GPW72_RS15810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW72_RS15815	COG0569	domain protein
GPW72_RS15820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW72_RS15820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW72_RS15825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW72_RS15830	COG0242	peptide deformylase activity
GPW72_RS15835	COG1652	LysM domain
GPW72_RS15840	COG0758	DNA mediated transformation
GPW72_RS15845	COG2922	Belongs to the Smg family
GPW72_RS15850	COG0551	DNA topoisomerase type I activity
GPW72_RS15855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPW72_RS15860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPW72_RS15865	COG0009	L-threonylcarbamoyladenylate synthase
GPW72_RS15870	COG0408	coproporphyrinogen oxidase activity
GPW72_RS15875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPW72_RS15885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPW72_RS15925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPW72_RS15930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPW72_RS15940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW72_RS15945	COG2104	thiamine diphosphate biosynthetic process
GPW72_RS15950	COG2022	thiamine diphosphate biosynthetic process
GPW72_RS15955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW72_RS15960	COG0006	proline dipeptidase activity
GPW72_RS15960	COG0006	proline dipeptidase activity
GPW72_RS15980	COG1522	sequence-specific DNA binding
GPW72_RS15985	COG5001	Diguanylate cyclase
GPW72_RS15985	COG5002	protein histidine kinase activity
GPW72_RS15990	COG0742	ribosomal rna small subunit methyltransferase
GPW72_RS16000	COG0697	spore germination
GPW72_RS16005	COG0589	response to stress
GPW72_RS16015	COG1528	Iron-storage protein
GPW72_RS16025	COG2081	HI0933 family
GPW72_RS16035	COG1322	Protein conserved in bacteria
GPW72_RS16040	COG2226	methyltransferase
GPW72_RS16050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPW72_RS16055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW72_RS16060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW72_RS16065	COG0805	protein transport
GPW72_RS16070	COG1858	cytochrome C peroxidase
GPW72_RS16075	COG0534	Mate efflux family protein
GPW72_RS16085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPW72_RS16090	COG2937	Belongs to the GPAT DAPAT family
GPW72_RS16095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPW72_RS16100	COG3161	chorismate lyase activity
GPW72_RS16110	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW72_RS16115	COG0840	transmembrane signaling receptor activity
GPW72_RS16125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW72_RS16130	COG0084	hydrolase, TatD family'
GPW72_RS16145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW72_RS16145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW72_RS16150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPW72_RS16165	COG3078	GTPase activator activity
GPW72_RS16175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW72_RS16180	COG3071	HemY protein
GPW72_RS16185	COG2959	enzyme of heme biosynthesis
GPW72_RS16190	COG1587	Uroporphyrinogen-III synthase
GPW72_RS16195	COG0181	hydroxymethylbilane synthase activity
GPW72_RS16205	COG3072	Adenylate cyclase
GPW72_RS16210	COG1965	Belongs to the frataxin family
GPW72_RS16220	COG0019	diaminopimelate decarboxylase activity
GPW72_RS16225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPW72_RS16235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPW72_RS16240	COG1011	Hydrolase
GPW72_RS16245	COG2200	EAL domain
GPW72_RS16245	COG2199	diguanylate cyclase activity
GPW72_RS16245	COG3287	FIST C domain
GPW72_RS16260	COG0561	phosphatase activity
GPW72_RS16265	COG2267	carboxylic ester hydrolase activity
GPW72_RS16270	COG1280	lysine exporter protein (LysE YggA)
GPW72_RS16275	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW72_RS16280	COG0783	Belongs to the Dps family
GPW72_RS16310	COG0742	ribosomal rna small subunit methyltransferase
GPW72_RS16315	COG0552	protein localization to endoplasmic reticulum
GPW72_RS16320	COG2884	Cell division ATP-binding protein ftsE
GPW72_RS16325	COG2177	Part of the ABC transporter FtsEX involved in
GPW72_RS16330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW72_RS16335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW72_RS16350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW72_RS16355	COG4206	TonB-dependent receptor
GPW72_RS16360	COG1404	Belongs to the peptidase S8 family
GPW72_RS16365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPW72_RS16435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPW72_RS16440	COG5001	Diguanylate cyclase
GPW72_RS16440	COG3300	MHYT domain
GPW72_RS16450	COG3852	Histidine kinase
GPW72_RS16460	COG0174	glutamine synthetase
GPW72_RS16475	COG1660	Displays ATPase and GTPase activities
GPW72_RS16485	COG1490	D-aminoacyl-tRNA deacylase activity
GPW72_RS16490	COG0456	acetyltransferase
GPW72_RS16500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPW72_RS16505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPW72_RS16510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPW72_RS16515	COG3031	protein transport across the cell outer membrane
GPW72_RS16525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW72_RS16530	COG1459	type II secretion system
GPW72_RS16535	COG2165	general secretion pathway protein
GPW72_RS16540	COG2165	general secretion pathway protein
GPW72_RS16545	COG2165	general secretion pathway protein
GPW72_RS16550	COG4795	General secretion pathway protein
GPW72_RS16555	COG3156	type II secretion system protein K
GPW72_RS16560	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW72_RS16565	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW72_RS16575	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPW72_RS16580	COG0494	nUDIX hydrolase
GPW72_RS16585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPW72_RS16585	COG0316	Belongs to the HesB IscA family
GPW72_RS16590	COG1040	competence protein
GPW72_RS16595	COG0596	Alpha beta hydrolase
GPW72_RS16605	COG2183	response to ionizing radiation
GPW72_RS16610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW72_RS16615	COG0745	RESPONSE REGULATOR receiver
GPW72_RS16625	COG2233	PERMEase
GPW72_RS16630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPW72_RS16635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW72_RS16640	COG1758	RNA polymerase activity
GPW72_RS16645	COG0194	GDP metabolic process
GPW72_RS16650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPW72_RS16655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW72_RS16665	COG3263	regulation of cellular component size
GPW72_RS16675	COG4232	protein-disulfide reductase activity
GPW72_RS16685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW72_RS16690	COG1027	Aspartate ammonia-lyase
GPW72_RS16695	COG3706	GGDEF domain
GPW72_RS16700	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPW72_RS16705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPW72_RS16715	COG2205	protein histidine kinase activity
GPW72_RS16720	COG0745	RESPONSE REGULATOR receiver
GPW72_RS16730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPW72_RS16735	COG0205	6-phosphofructokinase activity
GPW72_RS16740	COG1494	fructose-1,6-bisphosphatase
GPW72_RS16745	COG3074	FtsZ-dependent cytokinesis
GPW72_RS16750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPW72_RS16755	COG0460	homoserine dehydrogenase
GPW72_RS16755	COG0527	aspartate kinase activity
GPW72_RS16760	COG0626	cystathionine gamma-synthase activity
GPW72_RS16765	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPW72_RS16770	COG0281	malic enzyme
GPW72_RS16775	COG0254	rRNA binding
GPW72_RS16780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPW72_RS16785	COG1609	Transcriptional regulator
GPW72_RS16790	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW72_RS16795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPW72_RS16800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPW72_RS16805	COG1575	Belongs to the MenA family. Type 1 subfamily
GPW72_RS16810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW72_RS16820	COG0149	triose-phosphate isomerase activity
GPW72_RS16845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW72_RS16850	COG0459	protein refolding
GPW72_RS16860	COG1509	lysine 2,3-aminomutase activity
GPW72_RS16865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW72_RS16870	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW72_RS16875	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW72_RS16880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPW72_RS16885	COG1053	succinate dehydrogenase
GPW72_RS16890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPW72_RS16895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW72_RS16900	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPW72_RS16905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPW72_RS16910	COG1045	serine acetyltransferase
GPW72_RS16920	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPW72_RS16925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW72_RS16930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPW72_RS16935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW72_RS16940	COG0137	argininosuccinate synthase activity
GPW72_RS16945	COG0165	Argininosuccinate lyase
GPW72_RS16955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW72_RS16960	COG0678	peroxiredoxin activity
GPW72_RS16960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW72_RS16970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPW72_RS16990	COG3778	Protein conserved in bacteria
GPW72_RS16995	COG3299	homolog of phage Mu protein gp47
GPW72_RS17005	COG4384	Bacteriophage Mu Gp45 protein
GPW72_RS17020	COG3941	tape measure
GPW72_RS17035	COG4386	tail sheath protein
GPW72_RS17055	COG4387	Mu-like prophage protein GP36
GPW72_RS17065	COG4397	Mu-like prophage major head subunit gpT
GPW72_RS17100	COG4383	Mu-like prophage protein gp29
GPW72_RS17105	COG4373	Mu-like prophage FluMu protein gp28
GPW72_RS17115	COG0640	Transcriptional regulator
GPW72_RS17220	COG2842	Transposition protein
GPW72_RS17225	COG2801	Transposase and inactivated derivatives
GPW72_RS17230	COG3423	Transcriptional regulator
GPW72_RS17265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPW72_RS17270	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPW72_RS17280	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPW72_RS17285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPW72_RS17290	COG0546	phosphoglycolate phosphatase activity
GPW72_RS17295	COG0180	Tryptophanyl-tRNA synthetase
GPW72_RS17310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW72_RS17320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPW72_RS17340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW72_RS17345	COG3954	Phosphoribulokinase
GPW72_RS17355	COG0429	hydrolase of the alpha beta-hydrolase fold
GPW72_RS17365	COG0488	(ABC) transporter
GPW72_RS17370	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPW72_RS17385	COG1047	Peptidyl-prolyl cis-trans
GPW72_RS17395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPW72_RS17400	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPW72_RS17405	COG3083	sulfuric ester hydrolase activity
GPW72_RS17410	COG0557	exoribonuclease II activity
GPW72_RS17415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW72_RS17420	COG0051	transcription antitermination factor activity, RNA binding
GPW72_RS17425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPW72_RS17430	COG0088	Forms part of the polypeptide exit tunnel
GPW72_RS17435	COG0089	rRNA binding
GPW72_RS17440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPW72_RS17445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPW72_RS17450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPW72_RS17455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPW72_RS17460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPW72_RS17465	COG0255	Belongs to the universal ribosomal protein uL29 family
GPW72_RS17470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPW72_RS17475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPW72_RS17480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPW72_RS17485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPW72_RS17490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPW72_RS17495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPW72_RS17500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPW72_RS17505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPW72_RS17510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPW72_RS17515	COG1841	ribosomal large subunit assembly
GPW72_RS17520	COG0200	Binds to the 23S rRNA
GPW72_RS17525	COG0201	protein transport
GPW72_RS17535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPW72_RS17540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPW72_RS17545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPW72_RS17550	COG0202	RNA polymerase activity
GPW72_RS17555	COG0203	ribosomal protein L17
GPW72_RS17565	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW72_RS17570	COG3266	domain, Protein
GPW72_RS17570	COG3061	Opacity-associated protein A
GPW72_RS17575	COG0697	spore germination
GPW72_RS17580	COG2153	protein acetylation
GPW72_RS17585	COG0513	Belongs to the DEAD box helicase family
GPW72_RS17595	COG0737	Belongs to the 5'-nucleotidase family
GPW72_RS17600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPW72_RS17600	COG1648	precorrin-2 dehydrogenase activity
GPW72_RS17605	COG0175	sulfate reduction
GPW72_RS17610	COG2895	sulfate adenylyltransferase (ATP) activity
GPW72_RS17615	COG0529	Catalyzes the synthesis of activated sulfate
GPW72_RS17635	COG1136	(ABC) transporter
GPW72_RS17650	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPW72_RS17655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW72_RS17660	COG0729	surface antigen
GPW72_RS17670	COG2105	PFAM AIG2 family protein
GPW72_RS17675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPW72_RS17680	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPW72_RS17685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW72_RS17690	COG0163	prenyltransferase activity
GPW72_RS17695	COG4143	(ABC) transporter
GPW72_RS17700	COG1178	ABC-type Fe3 transport system permease component
GPW72_RS17705	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPW72_RS17710	COG3028	Belongs to the UPF0307 family
GPW72_RS17715	COG0312	modulator of DNA gyrase
GPW72_RS17720	COG2239	Acts as a magnesium transporter
GPW72_RS17725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW72_RS17735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW72_RS17740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW72_RS17750	COG1137	ATPase activity
GPW72_RS17755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPW72_RS17770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPW72_RS17770	COG0517	IMP dehydrogenase activity
GPW72_RS17780	COG1127	ABC transporter
GPW72_RS17785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPW72_RS17790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW72_RS17795	COG2854	intermembrane phospholipid transfer
GPW72_RS17805	COG5007	Belongs to the BolA IbaG family
GPW72_RS17810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPW72_RS17815	COG0204	Acyl-transferase
GPW72_RS17820	COG0251	oxidation-reduction process
GPW72_RS17825	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPW72_RS17830	COG0540	Belongs to the ATCase OTCase family
GPW72_RS17835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPW72_RS17840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPW72_RS17845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPW72_RS17850	COG0564	pseudouridine synthase activity
GPW72_RS17855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW72_RS17860	COG0525	valine-tRNA ligase activity
GPW72_RS17865	COG2927	DNA polymerase III (CHI subunit)
GPW72_RS17870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW72_RS17875	COG0795	lipopolysaccharide-transporting ATPase activity
GPW72_RS17880	COG0795	lipopolysaccharide-transporting ATPase activity
GPW72_RS17895	COG3437	response regulator, receiver
GPW72_RS17940	COG0066	3-isopropylmalate dehydratase activity
GPW72_RS17945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPW72_RS17950	COG0473	3-isopropylmalate dehydrogenase activity
GPW72_RS17955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW72_RS17975	COG0583	DNA-binding transcription factor activity
GPW72_RS17980	COG1022	Amp-dependent synthetase and ligase
GPW72_RS17985	COG0028	Belongs to the TPP enzyme family
GPW72_RS17990	COG0440	acetolactate synthase activity
GPW72_RS17995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW72_RS18000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPW72_RS18005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPW72_RS18015	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPW72_RS18025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW72_RS18030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW72_RS18040	COG0354	folic acid binding
GPW72_RS18045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPW72_RS18055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPW72_RS18060	COG1595	DNA-templated transcription, initiation
GPW72_RS18070	COG3026	antisigma factor binding
GPW72_RS18075	COG3086	response to oxidative stress
GPW72_RS18080	COG0481	GTPase activity
GPW72_RS18085	COG0681	Belongs to the peptidase S26 family
GPW72_RS18090	COG0571	ribonuclease III activity
GPW72_RS18095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPW72_RS18100	COG1381	Involved in DNA repair and RecF pathway recombination
GPW72_RS18105	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPW72_RS18110	COG0736	holo-[acyl-carrier-protein] synthase activity
GPW72_RS18125	COG5001	Diguanylate cyclase
GPW72_RS18135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW72_RS18140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW72_RS18145	COG3956	TIGRFAM MazG family protein
GPW72_RS18150	COG0504	CTP synthase activity
GPW72_RS18155	COG0148	phosphopyruvate hydratase activity
GPW72_RS18160	COG0617	tRNA 3'-terminal CCA addition
GPW72_RS18165	COG3267	Type II secretory pathway component ExeA
GPW72_RS18165	COG3409	Peptidoglycan-binding domain 1 protein
GPW72_RS18175	COG4991	sh3 domain protein
GPW72_RS18180	COG0306	phosphate transporter
GPW72_RS18185	COG1392	Phosphate transport regulator
GPW72_RS18190	COG3025	triphosphatase activity
GPW72_RS18195	COG0840	transmembrane signaling receptor activity
GPW72_RS18200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPW72_RS18210	COG1538	Outer membrane efflux protein
GPW72_RS18215	COG0494	nUDIX hydrolase
GPW72_RS18220	COG3151	Protein conserved in bacteria
GPW72_RS18230	COG3150	esterase
GPW72_RS18235	COG0187	DNA topoisomerase II activity
GPW72_RS18240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPW72_RS18245	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPW72_RS18250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPW72_RS18255	COG0237	dephospho-CoA kinase activity
GPW72_RS18265	COG1459	type II secretion system
GPW72_RS18270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW72_RS18290	COG0716	FMN binding
GPW72_RS18295	COG4974	Belongs to the 'phage' integrase family
GPW72_RS18300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW72_RS18305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPW72_RS18310	COG0737	Belongs to the 5'-nucleotidase family
GPW72_RS18315	COG2186	Transcriptional regulator
GPW72_RS18320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPW72_RS18325	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW72_RS18330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW72_RS18340	COG0275	rRNA processing
GPW72_RS18345	COG3116	cell division
GPW72_RS18350	COG0768	penicillin binding
GPW72_RS18355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPW72_RS18360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPW72_RS18365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPW72_RS18370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPW72_RS18375	COG0772	Belongs to the SEDS family
GPW72_RS18380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPW72_RS18385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW72_RS18390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPW72_RS18395	COG0849	cell division
GPW72_RS18400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPW72_RS18405	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPW72_RS18415	COG0653	protein targeting
GPW72_RS18420	COG0494	nUDIX hydrolase
GPW72_RS18425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPW72_RS18435	COG0505	Belongs to the CarA family
GPW72_RS18440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPW72_RS18455	COG4172	Belongs to the ABC transporter superfamily
GPW72_RS18465	COG0730	response to heat
GPW72_RS18470	COG0583	DNA-binding transcription factor activity
GPW72_RS18475	COG2860	membrane
GPW72_RS18480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPW72_RS18490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPW72_RS18500	COG0493	'glutamate synthase
GPW72_RS18505	COG0067	glutamate synthase
GPW72_RS18505	COG0070	glutamate synthase
GPW72_RS18505	COG0069	glutamate synthase activity
GPW72_RS18515	COG0069	glutamate synthase activity
GPW72_RS18515	COG0067	glutamate synthase
GPW72_RS18515	COG0070	glutamate synthase
GPW72_RS18520	COG1242	4 iron, 4 sulfur cluster binding
GPW72_RS18525	COG2203	Gaf domain
GPW72_RS18525	COG4251	negative regulation of phosphorylation
GPW72_RS18525	COG3706	GGDEF domain
GPW72_RS18525	COG5001	Diguanylate cyclase
GPW72_RS18530	COG0784	Response regulator, receiver
GPW72_RS18530	COG2198	Histidine kinase
GPW72_RS18530	COG5002	protein histidine kinase activity
GPW72_RS18535	COG0745	RESPONSE REGULATOR receiver
GPW72_RS18545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW72_RS18565	COG0083	homoserine kinase activity
GPW72_RS18570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPW72_RS18575	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPW72_RS18580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPW72_RS18585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPW72_RS18600	COG1115	amino acid carrier protein
GPW72_RS18615	COG0084	hydrolase, TatD family'
GPW72_RS18620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW72_RS18630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPW72_RS18635	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPW72_RS18640	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPW72_RS18645	COG0813	purine-nucleoside phosphorylase activity
GPW72_RS18655	COG0560	Phosphoserine phosphatase
GPW72_RS18665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPW72_RS18670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW72_RS18675	COG1022	Amp-dependent synthetase and ligase
GPW72_RS18690	COG3250	beta-galactosidase activity
GPW72_RS18695	COG1609	Transcriptional regulator
GPW72_RS18700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW72_RS18715	COG0189	ligase activity
GPW72_RS18715	COG0569	domain protein
GPW72_RS18720	COG0456	acetyltransferase
GPW72_RS18730	COG2171	N-acyltransferase activity
GPW72_RS18735	COG3141	response to X-ray
GPW72_RS18750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPW72_RS18755	COG1074	ATP-dependent DNA helicase activity
GPW72_RS18760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPW72_RS18770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPW72_RS18770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW72_RS18780	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPW72_RS18785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPW72_RS18790	COG2166	iron-sulfur cluster assembly
GPW72_RS18795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW72_RS18800	COG0693	protein deglycase activity
GPW72_RS18805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPW72_RS18810	COG3248	Nucleoside-binding outer membrane protein
GPW72_RS18820	COG1595	DNA-templated transcription, initiation
GPW72_RS18830	COG2211	Major facilitator Superfamily
GPW72_RS18840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW72_RS18850	COG2813	Specifically methylates the guanine in position
GPW72_RS18855	COG0271	Belongs to the BolA IbaG family
GPW72_RS18860	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW72_RS18865	COG1805	sodium ion transport
GPW72_RS18870	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW72_RS18875	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW72_RS18880	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW72_RS18885	COG2871	sodium ion transport
GPW72_RS18890	COG1477	protein flavinylation
GPW72_RS18900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPW72_RS18910	COG3706	GGDEF domain
GPW72_RS18915	COG0733	neurotransmitter:sodium symporter activity
GPW72_RS18925	COG0189	ligase activity
GPW72_RS18930	COG4067	protein conserved in archaea
GPW72_RS18930	COG0189	ligase activity
GPW72_RS18935	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW72_RS18940	COG2252	PERMEase
GPW72_RS18945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPW72_RS18960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPW72_RS18965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPW72_RS18970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPW72_RS18975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW72_RS18975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW72_RS18990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPW72_RS18995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW72_RS19000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPW72_RS19005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPW72_RS19015	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPW72_RS19020	COG0024	Methionine aminopeptidase
GPW72_RS19025	COG0052	Belongs to the universal ribosomal protein uS2 family
GPW72_RS19030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPW72_RS19035	COG0528	UMP kinase activity
GPW72_RS19040	COG0233	cytoplasmic translational termination
GPW72_RS19045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPW72_RS19050	COG0575	Belongs to the CDS family
GPW72_RS19055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPW72_RS19060	COG0750	zinc metalloprotease
GPW72_RS19070	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPW72_RS19075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW72_RS19080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW72_RS19085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW72_RS19090	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW72_RS19095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPW72_RS19100	COG0587	DNA-directed DNA polymerase activity
GPW72_RS19105	COG0825	malonyl-CoA metabolic process
GPW72_RS19110	COG0037	tRNA processing
GPW72_RS19120	COG3479	Phenolic acid decarboxylase
GPW72_RS19125	COG0347	Belongs to the P(II) protein family
GPW72_RS19135	COG0741	lytic transglycosylase activity
GPW72_RS19135	COG1388	LysM domain
GPW72_RS19140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW72_RS19145	COG2226	methyltransferase
GPW72_RS19150	COG0328	RNA-DNA hybrid ribonuclease activity
GPW72_RS19155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease