locus-tag	class	description
C1H56_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1H56_RS00010	COG0592	DNA-directed DNA polymerase activity
C1H56_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1H56_RS00020	COG0187	DNA topoisomerase II activity
C1H56_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
C1H56_RS00040	COG3977	Valine--pyruvate aminotransferase
C1H56_RS00050	COG0751	glycine-tRNA ligase activity
C1H56_RS00055	COG0752	glycyl-tRNA synthetase alpha subunit
C1H56_RS00060	COG2119	membrane
C1H56_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
C1H56_RS00085	COG0604	alcohol dehydrogenase
C1H56_RS00095	COG0129	dihydroxy-acid dehydratase activity
C1H56_RS00100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1H56_RS00115	COG0606	chelatase, subunit chli
C1H56_RS00120	COG0204	Acyl-transferase
C1H56_RS00125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1H56_RS00130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1H56_RS00145	COG3084	Protein conserved in bacteria
C1H56_RS00155	COG4326	sporulation control protein
C1H56_RS00160	COG1272	protein, Hemolysin III
C1H56_RS00170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1H56_RS00175	COG0569	domain protein
C1H56_RS00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1H56_RS00180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1H56_RS00185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1H56_RS00190	COG0242	peptide deformylase activity
C1H56_RS00195	COG1652	LysM domain
C1H56_RS00200	COG0758	DNA mediated transformation
C1H56_RS00205	COG2922	Belongs to the Smg family
C1H56_RS00210	COG0551	DNA topoisomerase type I activity
C1H56_RS00215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1H56_RS00220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1H56_RS00225	COG0009	L-threonylcarbamoyladenylate synthase
C1H56_RS00230	COG0408	coproporphyrinogen oxidase activity
C1H56_RS00235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1H56_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1H56_RS00280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1H56_RS00290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1H56_RS00300	COG1072	(Pantothenic acid kinase))
C1H56_RS00325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1H56_RS00330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1H56_RS00335	COG0250	Participates in transcription elongation, termination and antitermination
C1H56_RS00340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1H56_RS00350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1H56_RS00355	COG0222	ribosome binding
C1H56_RS00360	COG0085	RNA polymerase activity
C1H56_RS00365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1H56_RS00370	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1H56_RS00375	COG2816	NAD+ diphosphatase activity
C1H56_RS00380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1H56_RS00395	COG4942	peptidase
C1H56_RS00400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1H56_RS00410	COG0471	metal ion transport
C1H56_RS00410	COG0490	domain, Protein
C1H56_RS00415	COG0688	phosphatidylethanolamine metabolic process
C1H56_RS00420	COG1162	GTPase activity
C1H56_RS00425	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1H56_RS00480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1H56_RS00485	COG0802	atpase or kinase
C1H56_RS00495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1H56_RS00500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1H56_RS00505	COG1923	regulation of RNA biosynthetic process
C1H56_RS00510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1H56_RS00515	COG0330	HflC and HflK could
C1H56_RS00520	COG0330	HflC and HflK could
C1H56_RS00525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1H56_RS00530	COG2900	Belongs to the SlyX family
C1H56_RS00540	COG0545	Peptidyl-prolyl cis-trans isomerase
C1H56_RS00545	COG2964	Protein conserved in bacteria
C1H56_RS00550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1H56_RS00555	COG2923	Belongs to the DsrF TusC family
C1H56_RS00570	COG0049	tRNA binding
C1H56_RS00575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1H56_RS00580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1H56_RS00585	COG2906	2 iron, 2 sulfur cluster binding
C1H56_RS00595	COG0360	Binds together with S18 to 16S ribosomal RNA
C1H56_RS00600	COG2965	DNA replication, synthesis of RNA primer
C1H56_RS00605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1H56_RS00610	COG0359	binds to the 23S rRNA
C1H56_RS00625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1H56_RS00630	COG0432	Pfam Uncharacterised protein family UPF0047
C1H56_RS00650	COG0735	belongs to the Fur family
C1H56_RS00655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1H56_RS00680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1H56_RS00690	COG0175	sulfate reduction
C1H56_RS00760	COG1410	methionine synthase
C1H56_RS00760	COG0646	methionine synthase
C1H56_RS00765	COG0527	aspartate kinase activity
C1H56_RS00770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1H56_RS00780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1H56_RS00795	COG0629	single-stranded DNA binding
C1H56_RS00800	COG2200	EAL domain
C1H56_RS00800	COG2199	diguanylate cyclase activity
C1H56_RS00825	COG3409	Peptidoglycan-binding domain 1 protein
C1H56_RS00825	COG3267	Type II secretory pathway component ExeA
C1H56_RS00835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1H56_RS00840	COG1459	type II secretion system
C1H56_RS00850	COG2165	general secretion pathway protein
C1H56_RS00855	COG2165	general secretion pathway protein
C1H56_RS00885	COG1077	Cell shape determining protein MreB Mrl
C1H56_RS00890	COG1792	Involved in formation and maintenance of cell shape
C1H56_RS00895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1H56_RS00900	COG0424	maF-like protein
C1H56_RS00910	COG3164	Protein of unknown function
C1H56_RS00915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1H56_RS00920	COG0312	modulator of DNA gyrase
C1H56_RS00925	COG2235	arginine
C1H56_RS00945	COG0589	response to stress
C1H56_RS00955	COG2358	TRAP transporter, solute receptor (TAXI family
C1H56_RS00965	COG1438	arginine binding
C1H56_RS00970	COG0039	L-malate dehydrogenase activity
C1H56_RS00975	COG0531	amino acid
C1H56_RS00980	COG0142	geranyltranstransferase activity
C1H56_RS00985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1H56_RS00990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1H56_RS00995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1H56_RS01000	COG2966	Psort location CytoplasmicMembrane, score
C1H56_RS01005	COG3610	response to peptide
C1H56_RS01015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1H56_RS01020	COG2967	ApaG domain
C1H56_RS01025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1H56_RS01030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1H56_RS01035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1H56_RS01040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1H56_RS01045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1H56_RS01100	COG0741	lytic transglycosylase activity
C1H56_RS01105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C1H56_RS01110	COG1194	a g-specific adenine glycosylase
C1H56_RS01120	COG2066	Belongs to the glutaminase family
C1H56_RS01125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1H56_RS01130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1H56_RS01140	COG1872	DUF167
C1H56_RS01145	COG0762	integral membrane protein
C1H56_RS01150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1H56_RS01155	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1H56_RS01175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1H56_RS01180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1H56_RS01185	COG1678	Uncharacterized ACR, COG1678
C1H56_RS01190	COG0189	ligase activity
C1H56_RS01195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1H56_RS01200	COG2356	endonuclease I
C1H56_RS01210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1H56_RS01215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1H56_RS01220	COG0583	DNA-binding transcription factor activity
C1H56_RS01225	COG4771	TonB-dependent receptor
C1H56_RS01230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1H56_RS01235	COG0126	phosphoglycerate kinase activity
C1H56_RS01240	COG0191	fructose-bisphosphate aldolase activity
C1H56_RS01250	COG0668	transmembrane transport
C1H56_RS01255	COG1279	arginine transmembrane transporter activity
C1H56_RS01275	COG1349	DNA-binding transcription factor activity
C1H56_RS01280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1H56_RS01285	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1H56_RS01340	COG0328	RNA-DNA hybrid ribonuclease activity
C1H56_RS01355	COG4969	Belongs to the N-Me-Phe pilin family
C1H56_RS01365	COG0739	heme binding
C1H56_RS01400	COG2003	Belongs to the UPF0758 family
C1H56_RS01425	COG0582	viral genome integration into host DNA
C1H56_RS01440	COG0358	DNA primase activity
C1H56_RS01445	COG1610	YqeY-like protein
C1H56_RS01450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1H56_RS01455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1H56_RS01465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1H56_RS01475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1H56_RS01480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1H56_RS01485	COG1968	undecaprenyl-diphosphatase activity
C1H56_RS01490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1H56_RS01495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1H56_RS01500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1H56_RS01505	COG0585	pseudouridine synthase activity
C1H56_RS01510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1H56_RS01515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1H56_RS01525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1H56_RS01530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1H56_RS01550	COG4208	sulfate ABC transporter
C1H56_RS01555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1H56_RS01565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1H56_RS01575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1H56_RS01580	COG0527	aspartate kinase activity
C1H56_RS01585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1H56_RS01630	COG3630	sodium ion export across plasma membrane
C1H56_RS01635	COG5016	pyruvate
C1H56_RS01635	COG0511	ligase activity, forming carbon-carbon bonds
C1H56_RS01640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1H56_RS01650	COG1238	metal cluster binding
C1H56_RS01655	COG0612	Peptidase, M16
C1H56_RS01660	COG2918	glutathione biosynthetic process
C1H56_RS01665	COG1854	S-ribosylhomocysteine lyase activity
C1H56_RS01670	COG4536	flavin adenine dinucleotide binding
C1H56_RS01675	COG4137	Cytochrome C assembly protein
C1H56_RS01680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1H56_RS01685	COG0228	four-way junction DNA binding
C1H56_RS01690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1H56_RS01695	COG0336	Belongs to the RNA methyltransferase TrmD family
C1H56_RS01700	COG0335	large ribosomal subunit rRNA binding
C1H56_RS01705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1H56_RS01710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1H56_RS01720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1H56_RS01725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1H56_RS01730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1H56_RS01735	COG0723	plastoquinol--plastocyanin reductase activity
C1H56_RS01740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1H56_RS01745	COG2857	Cytochrome c1
C1H56_RS01750	COG0625	glutathione transferase activity
C1H56_RS01755	COG2969	positive regulation of protein catabolic process
C1H56_RS01760	COG2823	Periplasmic or secreted lipoprotein
C1H56_RS01765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1H56_RS01770	COG0792	nuclease activity
C1H56_RS01775	COG3107	peptidoglycan biosynthetic process
C1H56_RS01780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1H56_RS01800	COG0288	reversible hydration of carbon dioxide
C1H56_RS01805	COG0659	secondary active sulfate transmembrane transporter activity
C1H56_RS01810	COG1131	(ABC) transporter
C1H56_RS01815	COG0842	Transport permease protein
C1H56_RS01820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1H56_RS01825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1H56_RS01830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1H56_RS01840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1H56_RS01850	COG1489	DNA binding
C1H56_RS01860	COG1643	Atp-dependent helicase
C1H56_RS01865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1H56_RS01870	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1H56_RS01875	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1H56_RS01880	COG3112	Uncharacterised protein family (UPF0231)
C1H56_RS01885	COG0347	Belongs to the P(II) protein family
C1H56_RS01890	COG0004	ammonium transporteR
C1H56_RS01895	COG1840	ABC-type Fe3 transport system, periplasmic component
C1H56_RS01905	COG3842	ATPase activity
C1H56_RS01925	COG2971	BadF BadG BcrA BcrD
C1H56_RS01935	COG4608	Belongs to the ABC transporter superfamily
C1H56_RS01940	COG0444	Belongs to the ABC transporter superfamily
C1H56_RS01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1H56_RS01950	COG0601	transmembrane transport
C1H56_RS01955	COG0747	negative chemotaxis
C1H56_RS01965	COG2205	protein histidine kinase activity
C1H56_RS01965	COG0784	Response regulator, receiver
C1H56_RS01970	COG2813	Specifically methylates the guanine in position
C1H56_RS01975	COG0628	permease
C1H56_RS01980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1H56_RS01985	COG0316	Belongs to the HesB IscA family
C1H56_RS02000	COG0739	heme binding
C1H56_RS02005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1H56_RS02010	COG2027	D-alanyl-D-alanine carboxypeptidase
C1H56_RS02015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1H56_RS02020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1H56_RS02025	COG1534	Rna-binding protein
C1H56_RS02030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1H56_RS02035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1H56_RS02040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1H56_RS02055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1H56_RS02070	COG0779	Required for maturation of 30S ribosomal subunits
C1H56_RS02075	COG0195	Participates in both transcription termination and antitermination
C1H56_RS02080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1H56_RS02085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1H56_RS02095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1H56_RS02120	COG0826	peptidase U32
C1H56_RS02125	COG0826	peptidase U32
C1H56_RS02135	COG3154	lipid carrier protein
C1H56_RS02140	COG3153	acetyltransferase
C1H56_RS02165	COG0513	Belongs to the DEAD box helicase family
C1H56_RS02185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1H56_RS02190	COG2204	response regulator
C1H56_RS02200	COG0667	Aldo Keto reductase
C1H56_RS02210	COG0494	nUDIX hydrolase
C1H56_RS02215	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C1H56_RS02220	COG0730	response to heat
C1H56_RS02225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1H56_RS02235	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1H56_RS02240	COG0583	DNA-binding transcription factor activity
C1H56_RS02245	COG0640	Transcriptional regulator
C1H56_RS02250	COG0268	Binds directly to 16S ribosomal RNA
C1H56_RS02255	COG0728	peptidoglycan biosynthetic process
C1H56_RS02260	COG0196	riboflavin kinase activity
C1H56_RS02275	COG1047	Peptidyl-prolyl cis-trans
C1H56_RS02280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1H56_RS02285	COG1966	Carbon starvation protein
C1H56_RS02300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1H56_RS02305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1H56_RS02315	COG3279	Response regulator of the LytR AlgR family
C1H56_RS02320	COG3275	phosphorelay sensor kinase activity
C1H56_RS02325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1H56_RS02330	COG0287	Prephenate dehydrogenase
C1H56_RS02330	COG1605	Chorismate mutase
C1H56_RS02340	COG0488	(ABC) transporter
C1H56_RS02350	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
C1H56_RS02360	COG5001	Diguanylate cyclase
C1H56_RS02365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1H56_RS02370	COG1605	Chorismate mutase
C1H56_RS02370	COG0077	Prephenate dehydratase
C1H56_RS02375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1H56_RS02380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1H56_RS02385	COG0564	pseudouridine synthase activity
C1H56_RS02395	COG0542	response to heat
C1H56_RS02435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1H56_RS02440	COG0826	peptidase U32
C1H56_RS02450	COG0745	RESPONSE REGULATOR receiver
C1H56_RS02455	COG5002	protein histidine kinase activity
C1H56_RS02465	COG0248	Ppx GppA phosphatase
C1H56_RS02470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1H56_RS02480	COG0581	inorganic phosphate transmembrane transporter activity
C1H56_RS02485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1H56_RS02500	COG3142	Participates in the control of copper homeostasis
C1H56_RS02505	COG0450	alkyl hydroperoxide reductase
C1H56_RS02510	COG0583	DNA-binding transcription factor activity
C1H56_RS02515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1H56_RS02525	COG0517	IMP dehydrogenase activity
C1H56_RS02545	COG1862	Preprotein translocase
C1H56_RS02550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1H56_RS02555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1H56_RS02560	COG0483	inositol monophosphate 1-phosphatase activity
C1H56_RS02570	COG1959	2 iron, 2 sulfur cluster binding
C1H56_RS02575	COG1104	cysteine desulfurase activity
C1H56_RS02580	COG0822	iron-sulfur transferase activity
C1H56_RS02590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1H56_RS02595	COG0443	Heat shock 70 kDa protein
C1H56_RS02600	COG0633	Ferredoxin
C1H56_RS02605	COG2975	iron-sulfur cluster assembly
C1H56_RS02610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1H56_RS02615	COG0105	UTP biosynthetic process
C1H56_RS02620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1H56_RS02630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1H56_RS02635	COG0124	histidyl-tRNA synthetase
C1H56_RS02640	COG2976	Protein conserved in bacteria
C1H56_RS02645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1H56_RS02650	COG1160	GTP binding
C1H56_RS02665	COG1570	exodeoxyribonuclease VII activity
C1H56_RS02670	COG0517	IMP dehydrogenase activity
C1H56_RS02670	COG0516	GMP reductase activity
C1H56_RS02675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1H56_RS02675	COG0519	Catalyzes the synthesis of GMP from XMP
C1H56_RS02685	COG1584	GPR1 FUN34 yaaH family protein
C1H56_RS02690	COG3433	isochorismatase activity
C1H56_RS02690	COG1535	isochorismatase
C1H56_RS02695	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1H56_RS02700	COG1169	isochorismate synthase
C1H56_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
C1H56_RS02715	COG4592	Periplasmic binding protein
C1H56_RS02720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1H56_RS02725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1H56_RS02730	COG1120	ATPase activity
C1H56_RS02740	COG0583	DNA-binding transcription factor activity
C1H56_RS02745	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C1H56_RS02750	COG1115	amino acid carrier protein
C1H56_RS02760	COG0583	DNA-binding transcription factor activity
C1H56_RS02775	COG4565	transcriptional regulatory protein
C1H56_RS02785	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C1H56_RS02790	COG0511	ligase activity, forming carbon-carbon bonds
C1H56_RS02790	COG5016	pyruvate
C1H56_RS02795	COG3630	sodium ion export across plasma membrane
C1H56_RS02805	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C1H56_RS02815	COG2301	Belongs to the HpcH HpaI aldolase family
C1H56_RS02820	COG3051	citrate lyase alpha subunit
C1H56_RS02840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1H56_RS02845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1H56_RS02850	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1H56_RS02915	COG1012	belongs to the aldehyde dehydrogenase family
C1H56_RS02935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C1H56_RS02940	COG0840	transmembrane signaling receptor activity
C1H56_RS02945	COG3710	Transcriptional regulator
C1H56_RS02955	COG2165	general secretion pathway protein
C1H56_RS02970	COG4796	Type ii and iii secretion system protein
C1H56_RS02990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1H56_RS02995	COG1459	type II secretion system
C1H56_RS03005	COG2207	Transcriptional regulator
C1H56_RS03010	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C1H56_RS03030	COG0739	heme binding
C1H56_RS03040	COG3064	Membrane
C1H56_RS03045	COG0582	viral genome integration into host DNA
C1H56_RS03055	COG0582	viral genome integration into host DNA
C1H56_RS03065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1H56_RS03070	COG2867	negative regulation of translational initiation
C1H56_RS03075	COG2914	Belongs to the UPF0125 (RnfH) family
C1H56_RS03080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1H56_RS03085	COG0497	DNA recombination
C1H56_RS03090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1H56_RS03095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1H56_RS03100	COG0443	Heat shock 70 kDa protein
C1H56_RS03105	COG0484	heat shock protein binding
C1H56_RS03115	COG4968	Prepilin-type N-terminal cleavage methylation domain
C1H56_RS03140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1H56_RS03150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1H56_RS03160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1H56_RS03160	COG0047	phosphoribosylformylglycinamidine synthase activity
C1H56_RS03190	COG0442	prolyl-tRNA aminoacylation
C1H56_RS03195	COG1720	tRNA m6t6A37 methyltransferase activity
C1H56_RS03200	COG0254	rRNA binding
C1H56_RS03205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1H56_RS03210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C1H56_RS03215	COG1671	Belongs to the UPF0178 family
C1H56_RS03225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1H56_RS03240	COG3098	single-species biofilm formation
C1H56_RS03245	COG0564	pseudouridine synthase activity
C1H56_RS03250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1H56_RS03255	COG0142	geranyltranstransferase activity
C1H56_RS03260	COG1722	exodeoxyribonuclease VII activity
C1H56_RS03265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1H56_RS03275	COG0301	tRNA thio-modification
C1H56_RS03275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1H56_RS03280	COG0583	DNA-binding transcription factor activity
C1H56_RS03285	COG2363	Small membrane protein
C1H56_RS03290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1H56_RS03295	COG1611	Belongs to the LOG family
C1H56_RS03310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1H56_RS03310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1H56_RS03320	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C1H56_RS03325	COG1464	Belongs to the NlpA lipoprotein family
C1H56_RS03330	COG2011	ABC-type metal ion transport system permease component
C1H56_RS03335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1H56_RS03340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1H56_RS03345	COG1609	Transcriptional regulator
C1H56_RS03350	COG1263	PTS System
C1H56_RS03350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H56_RS03355	COG0366	Alpha amylase catalytic
C1H56_RS03385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1H56_RS03390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1H56_RS03395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C1H56_RS03400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C1H56_RS03405	COG0110	maltose O-acetyltransferase activity
C1H56_RS03425	COG1045	serine acetyltransferase
C1H56_RS03435	COG0438	transferase activity, transferring glycosyl groups
C1H56_RS03445	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C1H56_RS03475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1H56_RS03485	COG1596	polysaccharide export
C1H56_RS03510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1H56_RS03520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1H56_RS03525	COG0321	lipoyl(octanoyl) transferase activity
C1H56_RS03530	COG2921	Belongs to the UPF0250 family
C1H56_RS03535	COG1686	Belongs to the peptidase S11 family
C1H56_RS03540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1H56_RS03545	COG0772	Belongs to the SEDS family
C1H56_RS03550	COG0768	penicillin binding
C1H56_RS03555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1H56_RS03560	COG0799	negative regulation of ribosome biogenesis
C1H56_RS03565	COG1466	dna polymerase III delta subunit
C1H56_RS03570	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C1H56_RS03575	COG0495	leucyl-tRNA aminoacylation
C1H56_RS03580	COG2888	peptidyl-tyrosine sulfation
C1H56_RS03585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1H56_RS03590	COG4535	Mg2 and Co2 transporter CorC
C1H56_RS03600	COG1702	phosphate starvation-inducible protein PhoH
C1H56_RS03605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1H56_RS03610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1H56_RS03615	COG2190	(PTS) system
C1H56_RS03625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H56_RS03635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1H56_RS03640	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C1H56_RS03645	COG3115	cell septum assembly
C1H56_RS03650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1H56_RS03670	COG0789	Transcriptional regulator
C1H56_RS03675	COG1585	Membrane protein implicated in regulation of membrane protease activity
C1H56_RS03680	COG0330	HflC and HflK could
C1H56_RS03690	COG3118	belongs to the thioredoxin family
C1H56_RS03700	COG0300	oxidoreductase activity
C1H56_RS03705	COG1090	epimerase
C1H56_RS03710	COG0622	Phosphoesterase
C1H56_RS03725	COG3710	Transcriptional regulator
C1H56_RS03730	COG0326	Molecular chaperone. Has ATPase activity
C1H56_RS03735	COG0563	adenylate kinase activity
C1H56_RS03740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1H56_RS03755	COG0367	asparagine synthase
C1H56_RS03760	COG4651	solute:proton antiporter activity
C1H56_RS03760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1H56_RS03765	COG1846	Transcriptional regulator
C1H56_RS03765	COG1940	carbohydrate kinase activity
C1H56_RS03770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1H56_RS03775	COG1263	PTS System
C1H56_RS03775	COG2190	(PTS) system
C1H56_RS03775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H56_RS03790	COG0101	tRNA pseudouridine synthase activity
C1H56_RS03795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1H56_RS03800	COG0285	dihydrofolate synthase activity
C1H56_RS03805	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1H56_RS03810	COG1286	toxin biosynthetic process
C1H56_RS03815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1H56_RS03820	COG2056	Na+-H+ antiporter family
C1H56_RS03825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1H56_RS03840	COG0346	lactoylglutathione lyase activity
C1H56_RS03845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1H56_RS03865	COG4656	Part of a membrane complex involved in electron transport
C1H56_RS03870	COG2878	Part of a membrane complex involved in electron transport
C1H56_RS03875	COG4657	Part of a membrane complex involved in electron transport
C1H56_RS03885	COG0556	nucleotide-excision repair
C1H56_RS03895	COG2204	response regulator
C1H56_RS03900	COG2198	Histidine kinase
C1H56_RS03905	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1H56_RS03910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1H56_RS03915	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1H56_RS03920	COG0315	cyclic pyranopterin monophosphate synthase activity
C1H56_RS03925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1H56_RS03930	COG0314	molybdopterin synthase activity
C1H56_RS03935	COG2199	diguanylate cyclase activity
C1H56_RS03940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1H56_RS03940	COG0617	tRNA 3'-terminal CCA addition
C1H56_RS03940	COG0517	IMP dehydrogenase activity
C1H56_RS03955	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1H56_RS03965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H56_RS03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H56_RS03970	COG0489	protein tyrosine kinase activity
C1H56_RS03980	COG0572	uridine kinase
C1H56_RS03985	COG2982	Protein involved in outer membrane biogenesis
C1H56_RS03990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C1H56_RS03995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1H56_RS04025	COG0183	Belongs to the thiolase family
C1H56_RS04030	COG1024	Enoyl-CoA hydratase
C1H56_RS04030	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1H56_RS04035	COG0778	Nitroreductase
C1H56_RS04040	COG0583	DNA-binding transcription factor activity
C1H56_RS04045	COG0745	RESPONSE REGULATOR receiver
C1H56_RS04055	COG2832	Protein of unknown function (DUF454)
C1H56_RS04060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1H56_RS04070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1H56_RS04075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1H56_RS04085	COG2983	Belongs to the UPF0260 family
C1H56_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
C1H56_RS04095	COG0616	signal peptide processing
C1H56_RS04105	COG1522	sequence-specific DNA binding
C1H56_RS04110	COG1946	Acyl-CoA thioesterase
C1H56_RS04130	COG3706	GGDEF domain
C1H56_RS04140	COG0640	Transcriptional regulator
C1H56_RS04145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1H56_RS04170	COG1881	PFAM PEBP family protein
C1H56_RS04190	COG0009	L-threonylcarbamoyladenylate synthase
C1H56_RS04205	COG2201	protein-glutamate methylesterase activity
C1H56_RS04215	COG5002	protein histidine kinase activity
C1H56_RS04220	COG4191	Histidine kinase
C1H56_RS04225	COG3300	MHYT domain
C1H56_RS04225	COG5001	Diguanylate cyclase
C1H56_RS04230	COG2204	response regulator
C1H56_RS04250	COG0601	transmembrane transport
C1H56_RS04255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1H56_RS04260	COG0444	Belongs to the ABC transporter superfamily
C1H56_RS04265	COG4608	Belongs to the ABC transporter superfamily
C1H56_RS04270	COG0435	Glutathione S-transferase
C1H56_RS04275	COG0857	belongs to the CobB CobQ family
C1H56_RS04275	COG0280	phosphate acetyltransferase
C1H56_RS04280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1H56_RS04285	COG3092	negative regulation of chromosome organization
C1H56_RS04290	COG4628	conserved protein (DUF2132)
C1H56_RS04300	COG4120	Belongs to the binding-protein-dependent transport system permease family
C1H56_RS04310	COG2199	diguanylate cyclase activity
C1H56_RS04310	COG2203	Gaf domain
C1H56_RS04315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1H56_RS04325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1H56_RS04330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1H56_RS04335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1H56_RS04340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1H56_RS04345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1H56_RS04350	COG0156	8-amino-7-oxononanoate synthase activity
C1H56_RS04355	COG2226	methyltransferase
C1H56_RS04360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1H56_RS04370	COG0501	Belongs to the peptidase M48B family
C1H56_RS04380	COG0300	oxidoreductase activity
C1H56_RS04395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1H56_RS04405	COG2268	Band 7 protein
C1H56_RS04415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1H56_RS04420	COG2915	High frequency lysogenization protein hflD homolog
C1H56_RS04425	COG0482	sulfurtransferase activity
C1H56_RS04430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1H56_RS04435	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1H56_RS04440	COG1757	Na H antiporter
C1H56_RS04445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1H56_RS04450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1H56_RS04455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1H56_RS04460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1H56_RS04460	COG0131	Imidazoleglycerol-phosphate dehydratase
C1H56_RS04465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1H56_RS04470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1H56_RS04475	COG0107	imidazoleglycerol-phosphate synthase activity
C1H56_RS04480	COG0140	phosphoribosyl-ATP diphosphatase activity
C1H56_RS04480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1H56_RS04485	COG1187	pseudouridine synthase activity
C1H56_RS04495	COG1278	Cold shock
C1H56_RS04500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1H56_RS04505	COG0542	response to heat
C1H56_RS04510	COG2985	domain, Protein
C1H56_RS04510	COG3273	potassium ion transport
C1H56_RS04515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1H56_RS04520	COG1012	belongs to the aldehyde dehydrogenase family
C1H56_RS04520	COG1454	alcohol dehydrogenase
C1H56_RS04525	COG1737	Transcriptional regulator
C1H56_RS04530	COG0076	glutamate decarboxylase activity
C1H56_RS04540	COG2431	L-lysine efflux transmembrane transporter activity
C1H56_RS04550	COG3070	regulator of competence-specific genes
C1H56_RS04565	COG3852	Histidine kinase
C1H56_RS04575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1H56_RS04590	COG0189	ligase activity
C1H56_RS04590	COG4067	protein conserved in archaea
C1H56_RS04595	COG0500	methyltransferase
C1H56_RS04600	COG4106	trans-aconitate 2-methyltransferase activity
C1H56_RS04605	COG1801	Protein of unknown function DUF72
C1H56_RS04610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1H56_RS04615	COG1435	thymidine kinase activity
C1H56_RS04625	COG0159	tryptophan synthase activity
C1H56_RS04630	COG0133	tryptophan synthase activity
C1H56_RS04635	COG0134	indole-3-glycerol-phosphate synthase activity
C1H56_RS04635	COG0135	phosphoribosylanthranilate isomerase activity
C1H56_RS04640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1H56_RS04645	COG0512	Glutamine amidotransferase of anthranilate synthase
C1H56_RS04650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1H56_RS04660	COG0613	PHP domain protein
C1H56_RS04665	COG0009	L-threonylcarbamoyladenylate synthase
C1H56_RS04670	COG1187	pseudouridine synthase activity
C1H56_RS04675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1H56_RS04680	COG4988	ABC transporter
C1H56_RS04685	COG0492	ferredoxin-NADP+ reductase activity
C1H56_RS04695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1H56_RS04700	COG3706	GGDEF domain
C1H56_RS04705	COG2949	membrane
C1H56_RS04715	COG0281	malic enzyme
C1H56_RS04725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1H56_RS04745	COG2885	chlorophyll binding
C1H56_RS04760	COG0247	lactate metabolic process
C1H56_RS04760	COG0277	FAD linked oxidase domain protein
C1H56_RS04780	COG2986	histidine ammonia-lyase
C1H56_RS04785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1H56_RS04790	COG0010	Belongs to the arginase family
C1H56_RS04795	COG1228	amidohydrolase
C1H56_RS04810	COG3099	Belongs to the UPF0263 family
C1H56_RS04815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1H56_RS04825	COG5001	Diguanylate cyclase
C1H56_RS04830	COG0417	DNA replication proofreading
C1H56_RS04835	COG2197	response regulator
C1H56_RS04840	COG0322	excinuclease ABC activity
C1H56_RS04880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1H56_RS04885	COG0072	phenylalanine-tRNA ligase activity
C1H56_RS04885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H56_RS04890	COG0776	regulation of translation
C1H56_RS04930	COG1346	cytolysis
C1H56_RS04935	COG1380	Effector of murein hydrolase LrgA
C1H56_RS04940	COG2925	Exonuclease
C1H56_RS04945	COG1823	symporter activity
C1H56_RS04950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H56_RS04960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1H56_RS04965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1H56_RS04985	COG4139	cobalamin transport
C1H56_RS05040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1H56_RS05045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1H56_RS05050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1H56_RS05060	COG1054	Belongs to the UPF0176 family
C1H56_RS05070	COG2814	Major facilitator Superfamily
C1H56_RS05080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1H56_RS05105	COG2989	Protein conserved in bacteria
C1H56_RS05110	COG3108	Peptidase M15
C1H56_RS05115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1H56_RS05130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1H56_RS05160	COG1846	Transcriptional regulator
C1H56_RS05165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1H56_RS05170	COG0726	polysaccharide deacetylase
C1H56_RS05175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C1H56_RS05185	COG1447	Phosphotransferase system cellobiose-specific component IIA
C1H56_RS05190	COG1486	melibiose metabolic process
C1H56_RS05200	COG1609	Transcriptional regulator
C1H56_RS05205	COG2943	transferase activity, transferring hexosyl groups
C1H56_RS05210	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1H56_RS05215	COG0840	transmembrane signaling receptor activity
C1H56_RS05230	COG1448	Aminotransferase
C1H56_RS05245	COG0351	phosphomethylpyrimidine kinase
C1H56_RS05250	COG0017	Asparaginyl-tRNA synthetase
C1H56_RS05260	COG0720	synthase
C1H56_RS05265	COG1760	l-serine dehydratase
C1H56_RS05270	COG0814	amino acid
C1H56_RS05275	COG0494	nUDIX hydrolase
C1H56_RS05280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1H56_RS05295	COG3106	COG3106 Predicted ATPase
C1H56_RS05300	COG3768	UPF0283 membrane protein
C1H56_RS05310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1H56_RS05330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1H56_RS05340	COG0471	metal ion transport
C1H56_RS05345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H56_RS05345	COG4191	Histidine kinase
C1H56_RS05355	COG2990	Protein conserved in bacteria
C1H56_RS05360	COG3713	MltA-interacting MipA family protein
C1H56_RS05365	COG2205	protein histidine kinase activity
C1H56_RS05370	COG0745	RESPONSE REGULATOR receiver
C1H56_RS05400	COG1129	ABC transporter
C1H56_RS05440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1H56_RS05445	COG0372	Belongs to the citrate synthase family
C1H56_RS05485	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1H56_RS05495	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1H56_RS05505	COG0625	glutathione transferase activity
C1H56_RS05510	COG3437	response regulator, receiver
C1H56_RS05530	COG3706	GGDEF domain
C1H56_RS05535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1H56_RS05540	COG1254	Belongs to the acylphosphatase family
C1H56_RS05545	COG2920	part of a sulfur-relay system
C1H56_RS05550	COG0670	Belongs to the BI1 family
C1H56_RS05555	COG1126	abc transporter atp-binding protein
C1H56_RS05560	COG0765	amino acid transport
C1H56_RS05565	COG4597	amino acid ABC transporter
C1H56_RS05570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H56_RS05580	COG0561	phosphatase activity
C1H56_RS05585	COG0602	queuosine metabolic process
C1H56_RS05590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1H56_RS05620	COG3706	GGDEF domain
C1H56_RS05625	COG0443	Heat shock 70 kDa protein
C1H56_RS05630	COG0443	Heat shock 70 kDa protein
C1H56_RS05665	COG1643	Atp-dependent helicase
C1H56_RS05675	COG0443	Heat shock 70 kDa protein
C1H56_RS05680	COG0095	Lipoate-protein ligase
C1H56_RS05690	COG0583	DNA-binding transcription factor activity
C1H56_RS05695	COG0477	Major facilitator Superfamily
C1H56_RS05700	COG0415	Belongs to the DNA photolyase family
C1H56_RS05715	COG0745	RESPONSE REGULATOR receiver
C1H56_RS05725	COG2198	Histidine kinase
C1H56_RS05725	COG0643	Histidine kinase
C1H56_RS05730	COG0643	Histidine kinase
C1H56_RS05730	COG2198	Histidine kinase
C1H56_RS05730	COG0784	Response regulator, receiver
C1H56_RS05735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1H56_RS05745	COG2201	protein-glutamate methylesterase activity
C1H56_RS05750	COG0835	chemotaxis
C1H56_RS05755	COG0840	transmembrane signaling receptor activity
C1H56_RS05755	COG3290	protein histidine kinase activity
C1H56_RS05760	COG0840	transmembrane signaling receptor activity
C1H56_RS05770	COG0513	Belongs to the DEAD box helicase family
C1H56_RS05780	COG1538	Outer membrane efflux protein
C1H56_RS05785	COG1566	PFAM secretion protein HlyD family protein
C1H56_RS05790	COG2814	Major facilitator Superfamily
C1H56_RS05800	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1H56_RS05810	COG3501	Rhs element vgr protein
C1H56_RS05820	COG3675	Pfam Lipase (class 3)
C1H56_RS05835	COG1280	lysine exporter protein (LysE YggA)
C1H56_RS05840	COG1115	amino acid carrier protein
C1H56_RS05855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1H56_RS05865	COG1177	transmembrane transport
C1H56_RS05875	COG3842	ATPase activity
C1H56_RS05900	COG0589	response to stress
C1H56_RS05905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1H56_RS05920	COG2217	Heavy metal translocating P-type atpase
C1H56_RS05930	COG2010	Cytochrome c
C1H56_RS05945	COG3278	Belongs to the heme-copper respiratory oxidase family
C1H56_RS05960	COG0784	Response regulator, receiver
C1H56_RS05960	COG2205	protein histidine kinase activity
C1H56_RS05985	COG2994	toxin metabolic process
C1H56_RS05990	COG3064	Membrane
C1H56_RS05990	COG1073	alpha beta
C1H56_RS05990	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C1H56_RS06010	COG1476	TRANSCRIPTIONal
C1H56_RS06030	COG4128	Pfam Zonular occludens toxin
C1H56_RS06060	COG1476	TRANSCRIPTIONal
C1H56_RS06155	COG3120	sequence-specific DNA binding
C1H56_RS06160	COG1067	ATP-dependent peptidase activity
C1H56_RS06165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1H56_RS06180	COG0488	(ABC) transporter
C1H56_RS06190	COG0116	Belongs to the methyltransferase superfamily
C1H56_RS06190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1H56_RS06200	COG0167	dihydroorotate dehydrogenase activity
C1H56_RS06215	COG0308	aminopeptidase N
C1H56_RS06250	COG0641	radical SAM
C1H56_RS06330	COG4695	Portal protein
C1H56_RS06420	COG1428	Deoxynucleoside kinase
C1H56_RS06490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1H56_RS06495	COG0308	aminopeptidase N
C1H56_RS06510	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1H56_RS06515	COG1956	GAF domain-containing protein
C1H56_RS06520	COG1132	(ABC) transporter
C1H56_RS06525	COG2995	paraquat-inducible protein a
C1H56_RS06530	COG3008	intermembrane lipid transfer
C1H56_RS06540	COG2996	Protein conserved in bacteria
C1H56_RS06555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1H56_RS06560	COG1666	GTP binding
C1H56_RS06565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1H56_RS06580	COG0437	4 iron, 4 sulfur cluster binding
C1H56_RS06585	COG3383	formate dehydrogenase (NAD+) activity
C1H56_RS06585	COG0243	molybdopterin cofactor binding
C1H56_RS06615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1H56_RS06620	COG0488	(ABC) transporter
C1H56_RS06625	COG3852	Histidine kinase
C1H56_RS06630	COG2204	response regulator
C1H56_RS06640	COG4662	Binding-protein-dependent transport system inner membrane component
C1H56_RS06645	COG3842	ATPase activity
C1H56_RS06650	COG0746	molybdenum cofactor guanylyltransferase activity
C1H56_RS06685	COG1940	carbohydrate kinase activity
C1H56_RS06690	COG3148	PFAM DTW domain containing protein
C1H56_RS06700	COG0840	transmembrane signaling receptor activity
C1H56_RS06705	COG0791	NLP P60 protein
C1H56_RS06715	COG3001	Fructosamine kinase
C1H56_RS06725	COG0534	Mate efflux family protein
C1H56_RS06735	COG1793	dna ligase
C1H56_RS06750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1H56_RS06755	COG0848	biopolymer transport protein
C1H56_RS06760	COG0811	peptide transport
C1H56_RS06765	COG0811	peptide transport
C1H56_RS06780	COG1175	transmembrane transport
C1H56_RS06785	COG0395	ABC-type sugar transport system, permease component
C1H56_RS06790	COG3842	ATPase activity
C1H56_RS06795	COG1349	DNA-binding transcription factor activity
C1H56_RS06800	COG0584	glycerophosphoryl diester phosphodiesterase
C1H56_RS06805	COG2731	YhcH YjgK YiaL family protein
C1H56_RS06810	COG0251	oxidation-reduction process
C1H56_RS06815	COG1609	Transcriptional regulator
C1H56_RS06820	COG2723	6-phospho-beta-galactosidase activity
C1H56_RS06830	COG0583	DNA-binding transcription factor activity
C1H56_RS06850	COG0577	efflux transmembrane transporter activity
C1H56_RS06850	COG1136	(ABC) transporter
C1H56_RS06855	COG1136	(ABC) transporter
C1H56_RS06855	COG0577	efflux transmembrane transporter activity
C1H56_RS06860	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1H56_RS06860	COG1136	(ABC) transporter
C1H56_RS06865	COG1294	oxidase, subunit
C1H56_RS06870	COG1271	oxidase subunit
C1H56_RS06915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1H56_RS06925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1H56_RS06945	COG0753	catalase activity
C1H56_RS06960	COG3527	Alpha-acetolactate decarboxylase
C1H56_RS06975	COG2199	diguanylate cyclase activity
C1H56_RS06975	COG2200	EAL domain
C1H56_RS06985	COG2017	converts alpha-aldose to the beta-anomer
C1H56_RS06990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1H56_RS06995	COG1085	galactose-1-phosphate uridylyltransferase
C1H56_RS07040	COG0835	chemotaxis
C1H56_RS07040	COG0784	Response regulator, receiver
C1H56_RS07050	COG4565	transcriptional regulatory protein
C1H56_RS07055	COG3290	protein histidine kinase activity
C1H56_RS07070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H56_RS07090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1H56_RS07095	COG3063	Type IV pilus biogenesis stability protein PilW
C1H56_RS07110	COG1451	nucleotide metabolic process
C1H56_RS07120	COG0583	DNA-binding transcription factor activity
C1H56_RS07140	COG1538	Outer membrane efflux protein
C1H56_RS07155	COG1748	Saccharopine dehydrogenase
C1H56_RS07170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1H56_RS07180	COG0577	efflux transmembrane transporter activity
C1H56_RS07185	COG4181	ATPase activity
C1H56_RS07190	COG0534	Mate efflux family protein
C1H56_RS07195	COG0702	epimerase
C1H56_RS07205	COG2814	Major facilitator Superfamily
C1H56_RS07210	COG1187	pseudouridine synthase activity
C1H56_RS07215	COG1061	Type III restriction enzyme res subunit
C1H56_RS07235	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1H56_RS07240	COG4251	negative regulation of phosphorylation
C1H56_RS07240	COG3706	GGDEF domain
C1H56_RS07240	COG2203	Gaf domain
C1H56_RS07240	COG5001	Diguanylate cyclase
C1H56_RS07255	COG0840	transmembrane signaling receptor activity
C1H56_RS07285	COG4934	collagen metabolic process
C1H56_RS07300	COG0784	Response regulator, receiver
C1H56_RS07300	COG2205	protein histidine kinase activity
C1H56_RS07305	COG2239	Acts as a magnesium transporter
C1H56_RS07315	COG0814	amino acid
C1H56_RS07320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H56_RS07325	COG1131	(ABC) transporter
C1H56_RS07330	COG0842	Transport permease protein
C1H56_RS07340	COG3313	Fe-S protein
C1H56_RS07350	COG4134	Bacterial extracellular solute-binding protein
C1H56_RS07355	COG4135	transport system, permease component
C1H56_RS07360	COG4136	ATPase activity
C1H56_RS07365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1H56_RS07370	COG0564	pseudouridine synthase activity
C1H56_RS07375	COG0733	neurotransmitter:sodium symporter activity
C1H56_RS07390	COG0626	cystathionine gamma-synthase activity
C1H56_RS07395	COG2818	Glycosylase
C1H56_RS07410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H56_RS07425	COG1842	Phage shock protein A
C1H56_RS07430	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1H56_RS07440	COG4168	peptide transport system, permease
C1H56_RS07455	COG4172	Belongs to the ABC transporter superfamily
C1H56_RS07470	COG1227	inorganic diphosphatase activity
C1H56_RS07495	COG0243	molybdopterin cofactor binding
C1H56_RS07500	COG3005	denitrification pathway
C1H56_RS07505	COG4459	periplasmic nitrate reductase
C1H56_RS07515	COG2116	formate transmembrane transporter activity
C1H56_RS07530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1H56_RS07535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1H56_RS07550	COG1607	acyl-coa hydrolase
C1H56_RS07555	COG2350	Protein conserved in bacteria
C1H56_RS07565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1H56_RS07570	COG0583	DNA-binding transcription factor activity
C1H56_RS07585	COG0612	Peptidase, M16
C1H56_RS07590	COG5001	Diguanylate cyclase
C1H56_RS07595	COG1032	radical SAM domain protein
C1H56_RS07615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1H56_RS07625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1H56_RS07630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1H56_RS07635	COG0745	RESPONSE REGULATOR receiver
C1H56_RS07640	COG3381	protein complex oligomerization
C1H56_RS07650	COG1609	Transcriptional regulator
C1H56_RS07655	COG3070	regulator of competence-specific genes
C1H56_RS07675	COG0297	glycogen (starch) synthase activity
C1H56_RS07680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1H56_RS07685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1H56_RS07715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1H56_RS07725	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1H56_RS07750	COG1012	belongs to the aldehyde dehydrogenase family
C1H56_RS07755	COG1309	transcriptional regulator
C1H56_RS07780	COG0668	transmembrane transport
C1H56_RS07785	COG2995	paraquat-inducible protein a
C1H56_RS07790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1H56_RS07790	COG3008	intermembrane lipid transfer
C1H56_RS07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H56_RS07815	COG0582	viral genome integration into host DNA
C1H56_RS07820	COG0582	viral genome integration into host DNA
C1H56_RS07825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1H56_RS07845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1H56_RS07865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1H56_RS07885	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
C1H56_RS07890	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
C1H56_RS07895	COG1737	Transcriptional regulator
C1H56_RS07900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1H56_RS07905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1H56_RS07910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1H56_RS07915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1H56_RS07930	COG1940	carbohydrate kinase activity
C1H56_RS07935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1H56_RS07940	COG4409	exo-alpha-(2->6)-sialidase activity
C1H56_RS07950	COG2003	Belongs to the UPF0758 family
C1H56_RS07965	COG3941	tape measure
C1H56_RS08010	COG0488	(ABC) transporter
C1H56_RS08090	COG0415	Belongs to the DNA photolyase family
C1H56_RS08100	COG4628	conserved protein (DUF2132)
C1H56_RS08105	COG3284	Transcriptional regulator
C1H56_RS08110	COG1012	belongs to the aldehyde dehydrogenase family
C1H56_RS08120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H56_RS08125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H56_RS08130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H56_RS08140	COG2207	Transcriptional regulator
C1H56_RS08145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H56_RS08145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H56_RS08145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H56_RS08150	COG1482	cell wall glycoprotein biosynthetic process
C1H56_RS08160	COG5002	protein histidine kinase activity
C1H56_RS08160	COG0784	Response regulator, receiver
C1H56_RS08170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1H56_RS08180	COG2885	chlorophyll binding
C1H56_RS08185	COG0823	Involved in the tonB-independent uptake of proteins
C1H56_RS08200	COG0811	peptide transport
C1H56_RS08205	COG0824	Thioesterase
C1H56_RS08210	COG3790	cyd operon protein YbgE
C1H56_RS08215	COG4890	Cyd operon protein YbgT
C1H56_RS08220	COG1294	oxidase, subunit
C1H56_RS08225	COG1271	oxidase subunit
C1H56_RS08235	COG0632	four-way junction helicase activity
C1H56_RS08240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1H56_RS08245	COG0215	cysteine-tRNA ligase activity
C1H56_RS08250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1H56_RS08255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1H56_RS08260	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1H56_RS08265	COG3012	SEC-C Motif Domain Protein
C1H56_RS08270	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1H56_RS08275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1H56_RS08280	COG1199	ATP-dependent helicase activity
C1H56_RS08285	COG0730	response to heat
C1H56_RS08290	COG3923	Primosomal replication protein n
C1H56_RS08300	COG0840	transmembrane signaling receptor activity
C1H56_RS08305	COG0708	Exodeoxyribonuclease III
C1H56_RS08310	COG4160	amino acid transport
C1H56_RS08340	COG1882	Formate acetyltransferase
C1H56_RS08350	COG0840	transmembrane signaling receptor activity
C1H56_RS08355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1H56_RS08365	COG3013	Belongs to the UPF0304 family
C1H56_RS08370	COG2766	serine protein kinase
C1H56_RS08375	COG2718	Belongs to the UPF0229 family
C1H56_RS08380	COG2719	SpoVR family
C1H56_RS08385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1H56_RS08390	COG2835	tetraacyldisaccharide 4'-kinase activity
C1H56_RS08395	COG1663	tetraacyldisaccharide 4'-kinase activity
C1H56_RS08400	COG1132	(ABC) transporter
C1H56_RS08405	COG2333	competence protein COMEC
C1H56_RS08405	COG0658	competence protein
C1H56_RS08415	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1H56_RS08420	COG1136	(ABC) transporter
C1H56_RS08425	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1H56_RS08435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1H56_RS08455	COG1252	NADH dehydrogenase
C1H56_RS08460	COG3150	esterase
C1H56_RS08485	COG0537	adenosine 5'-monophosphoramidase activity
C1H56_RS08500	COG2186	Transcriptional regulator
C1H56_RS08505	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1H56_RS08510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1H56_RS08515	COG1674	ftsk spoiiie
C1H56_RS08525	COG0686	Belongs to the AlaDH PNT family
C1H56_RS08535	COG0583	DNA-binding transcription factor activity
C1H56_RS08555	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1H56_RS08560	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C1H56_RS08565	COG0776	regulation of translation
C1H56_RS08570	COG0539	negative regulation of cytoplasmic translation
C1H56_RS08575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1H56_RS08580	COG1555	photosystem II stabilization
C1H56_RS08585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1H56_RS08590	COG0776	regulation of translation
C1H56_RS08595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1H56_RS08600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1H56_RS08610	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1H56_RS08620	COG4191	Histidine kinase
C1H56_RS08630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1H56_RS08635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1H56_RS08640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1H56_RS08645	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1H56_RS08660	COG5001	Diguanylate cyclase
C1H56_RS08660	COG3300	MHYT domain
C1H56_RS08670	COG4589	Belongs to the CDS family
C1H56_RS08710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1H56_RS08720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1H56_RS08740	COG0243	molybdopterin cofactor binding
C1H56_RS08745	COG3005	denitrification pathway
C1H56_RS08750	COG3325	Belongs to the glycosyl hydrolase 18 family
C1H56_RS08750	COG3469	chitinase activity
C1H56_RS08755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1H56_RS08765	COG2951	lytic endotransglycosylase activity
C1H56_RS08770	COG3100	YcgL domain-containing protein
C1H56_RS08775	COG0850	regulation of cytokinetic process
C1H56_RS08780	COG2894	cell division
C1H56_RS08785	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1H56_RS08790	COG3015	lipoprotein NlpE involved in copper resistance
C1H56_RS08810	COG0477	Major facilitator Superfamily
C1H56_RS08815	COG0840	transmembrane signaling receptor activity
C1H56_RS08820	COG1396	sequence-specific DNA binding
C1H56_RS08825	COG3135	benzoate transporter
C1H56_RS08845	COG0596	Alpha beta hydrolase
C1H56_RS08850	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1H56_RS08855	COG1169	isochorismate synthase
C1H56_RS08860	COG0436	Aminotransferase
C1H56_RS08865	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1H56_RS08870	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1H56_RS08890	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1H56_RS08895	COG0318	PFAM AMP-dependent synthetase and ligase
C1H56_RS08900	COG0596	Alpha beta hydrolase
C1H56_RS08915	COG1214	PFAM Peptidase M22, glycoprotease
C1H56_RS08920	COG1199	ATP-dependent helicase activity
C1H56_RS08935	COG0788	formyltetrahydrofolate deformylase activity
C1H56_RS08940	COG1902	pentaerythritol trinitrate reductase activity
C1H56_RS08940	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1H56_RS08945	COG0616	signal peptide processing
C1H56_RS08950	COG0252	asparaginase activity
C1H56_RS08955	COG3139	Protein of unknown function (DUF1315)
C1H56_RS08965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H56_RS08970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1H56_RS08975	COG0676	glucose-6-phosphate 1-epimerase activity
C1H56_RS08995	COG2226	methyltransferase
C1H56_RS09010	COG0835	chemotaxis
C1H56_RS09010	COG0784	Response regulator, receiver
C1H56_RS09015	COG1940	carbohydrate kinase activity
C1H56_RS09025	COG4667	esterase of the alpha-beta hydrolase superfamily
C1H56_RS09040	COG0733	neurotransmitter:sodium symporter activity
C1H56_RS09045	COG1263	PTS System
C1H56_RS09045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H56_RS09050	COG0084	hydrolase, TatD family'
C1H56_RS09060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1H56_RS09065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1H56_RS09070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1H56_RS09075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1H56_RS09080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1H56_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
C1H56_RS09095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1H56_RS09100	COG0416	fatty acid biosynthetic process
C1H56_RS09105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1H56_RS09110	COG1399	metal-binding, possibly nucleic acid-binding protein
C1H56_RS09115	COG0424	maF-like protein
C1H56_RS09120	COG0564	pseudouridine synthase activity
C1H56_RS09135	COG1530	ribonuclease E activity
C1H56_RS09140	COG0659	secondary active sulfate transmembrane transporter activity
C1H56_RS09155	COG1012	belongs to the aldehyde dehydrogenase family
C1H56_RS09155	COG1454	alcohol dehydrogenase
C1H56_RS09160	COG2095	MarC family integral membrane protein
C1H56_RS09165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1H56_RS09170	COG1757	Na H antiporter
C1H56_RS09180	COG3081	Nucleoid-associated protein
C1H56_RS09185	COG3082	Protein of unknown function (DUF1414)
C1H56_RS09190	COG3083	sulfuric ester hydrolase activity
C1H56_RS09205	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1H56_RS09210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1H56_RS09215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1H56_RS09235	COG2853	Lipoprotein
C1H56_RS09245	COG4235	cytochrome complex assembly
C1H56_RS09245	COG3088	subunit of a heme lyase
C1H56_RS09250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1H56_RS09255	COG1138	Cytochrome C-type biogenesis protein
C1H56_RS09260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1H56_RS09270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1H56_RS09275	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1H56_RS09280	COG4133	protoheme IX ABC transporter activity
C1H56_RS09290	COG0835	chemotaxis
C1H56_RS09300	COG1192	Involved in chromosome partitioning
C1H56_RS09305	COG2201	protein-glutamate methylesterase activity
C1H56_RS09310	COG2198	Histidine kinase
C1H56_RS09310	COG0784	Response regulator, receiver
C1H56_RS09310	COG0643	Histidine kinase
C1H56_RS09315	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1H56_RS09345	COG2062	phosphohistidine phosphatase, SixA
C1H56_RS09350	COG1025	Belongs to the peptidase M16 family
C1H56_RS09360	COG0018	arginyl-trna synthetase
C1H56_RS09380	COG1918	ferrous iron import across plasma membrane
C1H56_RS09385	COG4977	sequence-specific DNA binding
C1H56_RS09390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1H56_RS09395	COG1121	(ABC) transporter
C1H56_RS09400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1H56_RS09410	COG0045	succinate-CoA ligase (ADP-forming) activity
C1H56_RS09415	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1H56_RS09420	COG0567	Dehydrogenase, E1 component
C1H56_RS09430	COG1053	succinate dehydrogenase
C1H56_RS09435	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1H56_RS09440	COG2009	succinate dehydrogenase
C1H56_RS09445	COG0372	Belongs to the citrate synthase family
C1H56_RS09450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1H56_RS09460	COG0033	Phosphoglucomutase
C1H56_RS09465	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1H56_RS09470	COG0596	Alpha beta hydrolase
C1H56_RS09485	COG1346	cytolysis
C1H56_RS09495	COG0583	DNA-binding transcription factor activity
C1H56_RS09505	COG0735	belongs to the Fur family
C1H56_RS09510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1H56_RS09515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1H56_RS09520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1H56_RS09530	COG0431	NADPH-dependent FMN reductase
C1H56_RS09540	COG3101	peptidyl-lysine hydroxylation
C1H56_RS09545	COG2860	membrane
C1H56_RS09550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1H56_RS09560	COG2890	protein-(glutamine-N5) methyltransferase activity
C1H56_RS09565	COG2840	Smr protein MutS2
C1H56_RS09575	COG1684	flagellar biosynthetic protein fliR
C1H56_RS09580	COG1987	bacterial-type flagellum assembly
C1H56_RS09605	COG1580	Controls the rotational direction of flagella during chemotaxis
C1H56_RS09630	COG1317	bacterial-type flagellum organization
C1H56_RS09635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1H56_RS09645	COG1677	Flagellar hook-basal body complex protein FliE
C1H56_RS09665	COG1516	flagellar protein fliS
C1H56_RS09675	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C1H56_RS09680	COG1334	flagellar protein FlaG
C1H56_RS09685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1H56_RS09690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1H56_RS09695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1H56_RS09700	COG2837	iron assimilation
C1H56_RS09720	COG1393	Belongs to the ArsC family
C1H56_RS09730	COG1876	peptidase activity
C1H56_RS09740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1H56_RS09755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1H56_RS09775	COG4783	chaperone-mediated protein folding
C1H56_RS09780	COG1393	Belongs to the ArsC family
C1H56_RS09800	COG2233	PERMEase
C1H56_RS09805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1H56_RS09810	COG0737	Belongs to the 5'-nucleotidase family
C1H56_RS09815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1H56_RS09820	COG2912	Transglutaminase-like superfamily
C1H56_RS09830	COG2890	protein-(glutamine-N5) methyltransferase activity
C1H56_RS09835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1H56_RS09840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1H56_RS09845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1H56_RS09855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1H56_RS09860	COG0193	aminoacyl-tRNA hydrolase activity
C1H56_RS09865	COG0012	GTP binding
C1H56_RS09950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1H56_RS09955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1H56_RS09970	COG1705	Flagellar rod assembly protein muramidase FlgJ
C1H56_RS09970	COG3951	Flagellar rod assembly protein muramidase FlgJ
C1H56_RS09975	COG1706	bacterial-type flagellum-dependent cell motility
C1H56_RS09980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1H56_RS09990	COG4787	bacterial-type flagellum-dependent cell motility
C1H56_RS09995	COG1749	Flagellar hook protein flgE
C1H56_RS10010	COG1815	bacterial-type flagellum-dependent cell motility
C1H56_RS10015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1H56_RS10020	COG0835	chemotaxis
C1H56_RS10020	COG0784	Response regulator, receiver
C1H56_RS10055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1H56_RS10055	COG2226	methyltransferase
C1H56_RS10055	COG3433	isochorismatase activity
C1H56_RS10060	COG2375	cellular response to nickel ion
C1H56_RS10065	COG4774	siderophore transport
C1H56_RS10065	COG1629	transport
C1H56_RS10080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1H56_RS10085	COG2217	Heavy metal translocating P-type atpase
C1H56_RS10085	COG2608	mercury ion transmembrane transporter activity
C1H56_RS10100	COG3735	TraB family
C1H56_RS10115	COG2840	Smr protein MutS2
C1H56_RS10120	COG1187	pseudouridine synthase activity
C1H56_RS10130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1H56_RS10135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1H56_RS10140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1H56_RS10145	COG0121	glutamine amidotransferase
C1H56_RS10150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1H56_RS10155	COG1960	acyl-CoA dehydrogenase activity
C1H56_RS10170	COG0328	RNA-DNA hybrid ribonuclease activity
C1H56_RS10175	COG2226	methyltransferase
C1H56_RS10180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1H56_RS10185	COG1388	LysM domain
C1H56_RS10185	COG0741	lytic transglycosylase activity
C1H56_RS10190	COG3021	interspecies interaction between organisms
C1H56_RS10195	COG0347	Belongs to the P(II) protein family
C1H56_RS10200	COG3479	Phenolic acid decarboxylase
C1H56_RS10210	COG0037	tRNA processing
C1H56_RS10215	COG0825	malonyl-CoA metabolic process
C1H56_RS10220	COG0587	DNA-directed DNA polymerase activity
C1H56_RS10225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1H56_RS10230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1H56_RS10235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1H56_RS10240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1H56_RS10245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1H56_RS10250	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C1H56_RS10260	COG0750	zinc metalloprotease
C1H56_RS10265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1H56_RS10270	COG0575	Belongs to the CDS family
C1H56_RS10275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1H56_RS10280	COG0233	cytoplasmic translational termination
C1H56_RS10285	COG0528	UMP kinase activity
C1H56_RS10290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1H56_RS10295	COG0052	Belongs to the universal ribosomal protein uS2 family
C1H56_RS10300	COG0024	Methionine aminopeptidase
C1H56_RS10305	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1H56_RS10320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1H56_RS10325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1H56_RS10330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1H56_RS10335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1H56_RS10350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1H56_RS10350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1H56_RS10355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1H56_RS10360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1H56_RS10365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1H56_RS10375	COG1073	alpha beta
C1H56_RS10380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1H56_RS10385	COG2252	PERMEase
C1H56_RS10390	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1H56_RS10395	COG4067	protein conserved in archaea
C1H56_RS10395	COG0189	ligase activity
C1H56_RS10400	COG0189	ligase activity
C1H56_RS10410	COG0733	neurotransmitter:sodium symporter activity
C1H56_RS10415	COG3706	GGDEF domain
C1H56_RS10435	COG1477	protein flavinylation
C1H56_RS10440	COG2871	sodium ion transport
C1H56_RS10445	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1H56_RS10450	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1H56_RS10455	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1H56_RS10460	COG1805	sodium ion transport
C1H56_RS10465	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1H56_RS10470	COG0271	Belongs to the BolA IbaG family
C1H56_RS10475	COG2813	Specifically methylates the guanine in position
C1H56_RS10485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1H56_RS10495	COG2211	Major facilitator Superfamily
C1H56_RS10505	COG1595	DNA-templated transcription, initiation
C1H56_RS10515	COG3248	Nucleoside-binding outer membrane protein
C1H56_RS10520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1H56_RS10525	COG0693	protein deglycase activity
C1H56_RS10530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1H56_RS10535	COG2166	iron-sulfur cluster assembly
C1H56_RS10540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1H56_RS10545	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1H56_RS10555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1H56_RS10555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1H56_RS10565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1H56_RS10570	COG1074	ATP-dependent DNA helicase activity
C1H56_RS10575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1H56_RS10590	COG3141	response to X-ray
C1H56_RS10595	COG2171	N-acyltransferase activity
C1H56_RS10605	COG0456	acetyltransferase
C1H56_RS10610	COG0569	domain protein
C1H56_RS10610	COG0189	ligase activity
C1H56_RS10625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1H56_RS10630	COG1609	Transcriptional regulator
C1H56_RS10635	COG3250	beta-galactosidase activity
C1H56_RS10650	COG1022	Amp-dependent synthetase and ligase
C1H56_RS10655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1H56_RS10660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1H56_RS10675	COG0560	Phosphoserine phosphatase
C1H56_RS10685	COG0813	purine-nucleoside phosphorylase activity
C1H56_RS10690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1H56_RS10695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1H56_RS10700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1H56_RS10710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1H56_RS10715	COG0084	hydrolase, TatD family'
C1H56_RS10720	COG3022	response to hydroperoxide
C1H56_RS10725	COG1115	amino acid carrier protein
C1H56_RS10740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1H56_RS10745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1H56_RS10750	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
C1H56_RS10755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1H56_RS10780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1H56_RS10790	COG0745	RESPONSE REGULATOR receiver
C1H56_RS10795	COG0784	Response regulator, receiver
C1H56_RS10795	COG2198	Histidine kinase
C1H56_RS10795	COG5002	protein histidine kinase activity
C1H56_RS10800	COG3706	GGDEF domain
C1H56_RS10800	COG5001	Diguanylate cyclase
C1H56_RS10800	COG4251	negative regulation of phosphorylation
C1H56_RS10800	COG2203	Gaf domain
C1H56_RS10805	COG1242	4 iron, 4 sulfur cluster binding
C1H56_RS10810	COG0070	glutamate synthase
C1H56_RS10810	COG0069	glutamate synthase activity
C1H56_RS10810	COG0067	glutamate synthase
C1H56_RS10820	COG0067	glutamate synthase
C1H56_RS10820	COG0069	glutamate synthase activity
C1H56_RS10820	COG0070	glutamate synthase
C1H56_RS10825	COG0493	'glutamate synthase
C1H56_RS10835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1H56_RS10845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1H56_RS10850	COG2860	membrane
C1H56_RS10855	COG0583	DNA-binding transcription factor activity
C1H56_RS10860	COG0730	response to heat
C1H56_RS10870	COG4172	Belongs to the ABC transporter superfamily
C1H56_RS10890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1H56_RS10895	COG0505	Belongs to the CarA family
C1H56_RS10905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1H56_RS10910	COG0494	nUDIX hydrolase
C1H56_RS10915	COG0653	protein targeting
C1H56_RS10925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1H56_RS10930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1H56_RS10935	COG0849	cell division
C1H56_RS10940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1H56_RS10945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1H56_RS10955	COG0772	Belongs to the SEDS family
C1H56_RS10960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1H56_RS10970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1H56_RS10975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1H56_RS10980	COG0768	penicillin binding
C1H56_RS10985	COG3116	cell division
C1H56_RS11000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1H56_RS11005	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1H56_RS11010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1H56_RS11015	COG2186	Transcriptional regulator
C1H56_RS11025	COG0737	Belongs to the 5'-nucleotidase family
C1H56_RS11030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1H56_RS11035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1H56_RS11040	COG4974	Belongs to the 'phage' integrase family
C1H56_RS11045	COG0716	FMN binding
C1H56_RS11065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1H56_RS11070	COG1459	type II secretion system
C1H56_RS11080	COG0237	dephospho-CoA kinase activity
C1H56_RS11085	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1H56_RS11095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1H56_RS11100	COG0187	DNA topoisomerase II activity
C1H56_RS11105	COG3150	esterase
C1H56_RS11115	COG3151	Protein conserved in bacteria
C1H56_RS11120	COG0494	nUDIX hydrolase
C1H56_RS11125	COG1538	Outer membrane efflux protein
C1H56_RS11135	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1H56_RS11140	COG0840	transmembrane signaling receptor activity
C1H56_RS11145	COG3025	triphosphatase activity
C1H56_RS11150	COG1392	Phosphate transport regulator
C1H56_RS11155	COG0306	phosphate transporter
C1H56_RS11160	COG4991	sh3 domain protein
C1H56_RS11170	COG3267	Type II secretory pathway component ExeA
C1H56_RS11170	COG3409	Peptidoglycan-binding domain 1 protein
C1H56_RS11180	COG0148	phosphopyruvate hydratase activity
C1H56_RS11185	COG0504	CTP synthase activity
C1H56_RS11190	COG3956	TIGRFAM MazG family protein
C1H56_RS11195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1H56_RS11210	COG5001	Diguanylate cyclase
C1H56_RS11230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1H56_RS11235	COG1381	Involved in DNA repair and RecF pathway recombination
C1H56_RS11240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1H56_RS11255	COG0481	GTPase activity
C1H56_RS11260	COG3086	response to oxidative stress
C1H56_RS11275	COG1595	DNA-templated transcription, initiation
C1H56_RS11285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1H56_RS11295	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1H56_RS11310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1H56_RS11315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1H56_RS11320	COG3079	Belongs to the UPF0149 family
C1H56_RS11325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C1H56_RS11335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1H56_RS11340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1H56_RS11345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1H56_RS11350	COG0440	acetolactate synthase activity
C1H56_RS11355	COG0028	Belongs to the TPP enzyme family
C1H56_RS11360	COG1022	Amp-dependent synthetase and ligase
C1H56_RS11365	COG0583	DNA-binding transcription factor activity
C1H56_RS11390	COG0473	3-isopropylmalate dehydrogenase activity
C1H56_RS11395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1H56_RS11400	COG0066	3-isopropylmalate dehydratase activity
C1H56_RS11445	COG3437	response regulator, receiver
C1H56_RS11460	COG0795	lipopolysaccharide-transporting ATPase activity
C1H56_RS11465	COG0795	lipopolysaccharide-transporting ATPase activity
C1H56_RS11470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1H56_RS11475	COG2927	DNA polymerase III (CHI subunit)
C1H56_RS11480	COG0525	valine-tRNA ligase activity
C1H56_RS11485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1H56_RS11490	COG0564	pseudouridine synthase activity
C1H56_RS11505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1H56_RS11515	COG0540	Belongs to the ATCase OTCase family
C1H56_RS11525	COG0251	oxidation-reduction process
C1H56_RS11535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1H56_RS11540	COG5007	Belongs to the BolA IbaG family
C1H56_RS11550	COG2854	intermembrane phospholipid transfer
C1H56_RS11555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1H56_RS11560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1H56_RS11565	COG1127	ABC transporter
C1H56_RS11580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1H56_RS11580	COG0517	IMP dehydrogenase activity
C1H56_RS11595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1H56_RS11600	COG1137	ATPase activity
C1H56_RS11610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1H56_RS11615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H56_RS11620	COG1660	Displays ATPase and GTPase activities
C1H56_RS11625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H56_RS11630	COG2239	Acts as a magnesium transporter
C1H56_RS11635	COG0312	modulator of DNA gyrase
C1H56_RS11640	COG3028	Belongs to the UPF0307 family
C1H56_RS11645	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1H56_RS11650	COG1178	ABC-type Fe3 transport system permease component
C1H56_RS11660	COG0163	prenyltransferase activity
C1H56_RS11665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1H56_RS11680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1H56_RS11685	COG2105	PFAM AIG2 family protein
C1H56_RS11695	COG0729	surface antigen
C1H56_RS11700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H56_RS11705	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1H56_RS11720	COG1136	(ABC) transporter
C1H56_RS11740	COG0529	Catalyzes the synthesis of activated sulfate
C1H56_RS11755	COG1648	precorrin-2 dehydrogenase activity
C1H56_RS11755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1H56_RS11760	COG0737	Belongs to the 5'-nucleotidase family
C1H56_RS11770	COG0513	Belongs to the DEAD box helicase family
C1H56_RS11775	COG2153	protein acetylation
C1H56_RS11780	COG0697	spore germination
C1H56_RS11785	COG3061	Opacity-associated protein A
C1H56_RS11785	COG3266	domain, Protein
C1H56_RS11790	COG0545	Peptidyl-prolyl cis-trans isomerase
C1H56_RS11800	COG0203	ribosomal protein L17
C1H56_RS11805	COG0202	RNA polymerase activity
C1H56_RS11810	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1H56_RS11815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1H56_RS11820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1H56_RS11825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1H56_RS11830	COG0201	protein transport
C1H56_RS11840	COG1841	ribosomal large subunit assembly
C1H56_RS11845	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1H56_RS11850	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1H56_RS11860	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1H56_RS11865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1H56_RS11870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1H56_RS11875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1H56_RS11880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1H56_RS11885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1H56_RS11890	COG0255	Belongs to the universal ribosomal protein uL29 family
C1H56_RS11895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1H56_RS11900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1H56_RS11905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1H56_RS11910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1H56_RS11915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1H56_RS11920	COG0089	rRNA binding
C1H56_RS11925	COG0088	Forms part of the polypeptide exit tunnel
C1H56_RS11930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1H56_RS11935	COG0051	transcription antitermination factor activity, RNA binding
C1H56_RS11940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1H56_RS11945	COG0557	exoribonuclease II activity
C1H56_RS11950	COG3083	sulfuric ester hydrolase activity
C1H56_RS11955	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1H56_RS11975	COG1047	Peptidyl-prolyl cis-trans
C1H56_RS11990	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1H56_RS11995	COG0488	(ABC) transporter
C1H56_RS12005	COG0429	hydrolase of the alpha beta-hydrolase fold
C1H56_RS12015	COG3954	Phosphoribulokinase
C1H56_RS12030	COG1012	belongs to the aldehyde dehydrogenase family
C1H56_RS12040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1H56_RS12050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1H56_RS12065	COG0180	Tryptophanyl-tRNA synthetase
C1H56_RS12070	COG0546	phosphoglycolate phosphatase activity
C1H56_RS12075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1H56_RS12080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1H56_RS12090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1H56_RS12095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1H56_RS12125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1H56_RS12135	COG0678	peroxiredoxin activity
C1H56_RS12135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1H56_RS12140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1H56_RS12150	COG0165	Argininosuccinate lyase
C1H56_RS12160	COG0137	argininosuccinate synthase activity
C1H56_RS12165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1H56_RS12170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1H56_RS12175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1H56_RS12180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1H56_RS12190	COG1045	serine acetyltransferase
C1H56_RS12195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1H56_RS12200	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1H56_RS12205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1H56_RS12210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C1H56_RS12215	COG1053	succinate dehydrogenase
C1H56_RS12220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1H56_RS12225	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1H56_RS12235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1H56_RS12240	COG1509	lysine 2,3-aminomutase activity
C1H56_RS12250	COG0459	protein refolding
C1H56_RS12255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1H56_RS12285	COG0149	triose-phosphate isomerase activity
C1H56_RS12290	COG0534	Mate efflux family protein
C1H56_RS12295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1H56_RS12300	COG1575	Belongs to the MenA family. Type 1 subfamily
C1H56_RS12305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1H56_RS12310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1H56_RS12315	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1H56_RS12320	COG1609	Transcriptional regulator
C1H56_RS12325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1H56_RS12330	COG0254	rRNA binding
C1H56_RS12335	COG0281	malic enzyme
C1H56_RS12340	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
C1H56_RS12345	COG0626	cystathionine gamma-synthase activity
C1H56_RS12350	COG0460	homoserine dehydrogenase
C1H56_RS12350	COG0527	aspartate kinase activity
C1H56_RS12355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1H56_RS12360	COG3074	FtsZ-dependent cytokinesis
C1H56_RS12365	COG1494	fructose-1,6-bisphosphatase
C1H56_RS12370	COG0205	6-phosphofructokinase activity
C1H56_RS12375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1H56_RS12385	COG0745	RESPONSE REGULATOR receiver
C1H56_RS12390	COG2205	protein histidine kinase activity
C1H56_RS12400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1H56_RS12405	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1H56_RS12410	COG3706	GGDEF domain
C1H56_RS12415	COG1027	Aspartate ammonia-lyase
C1H56_RS12420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1H56_RS12430	COG4232	protein-disulfide reductase activity
C1H56_RS12450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1H56_RS12455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1H56_RS12460	COG0194	GDP metabolic process
C1H56_RS12465	COG1758	RNA polymerase activity
C1H56_RS12470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1H56_RS12475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1H56_RS12480	COG2233	PERMEase
C1H56_RS12495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1H56_RS12500	COG2183	response to ionizing radiation
C1H56_RS12510	COG0596	Alpha beta hydrolase
C1H56_RS12515	COG1040	competence protein
C1H56_RS12525	COG0494	nUDIX hydrolase
C1H56_RS12530	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1H56_RS12540	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1H56_RS12545	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1H56_RS12550	COG3156	type II secretion system protein K
C1H56_RS12555	COG4795	General secretion pathway protein
C1H56_RS12560	COG2165	general secretion pathway protein
C1H56_RS12565	COG2165	general secretion pathway protein
C1H56_RS12570	COG2165	general secretion pathway protein
C1H56_RS12575	COG1459	type II secretion system
C1H56_RS12580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1H56_RS12590	COG3031	protein transport across the cell outer membrane
C1H56_RS12595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1H56_RS12600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1H56_RS12605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1H56_RS12615	COG0456	acetyltransferase
C1H56_RS12620	COG1490	D-aminoacyl-tRNA deacylase activity
C1H56_RS12625	COG1295	ribonuclease BN
C1H56_RS12630	COG1660	Displays ATPase and GTPase activities
C1H56_RS12635	COG1217	gtp-binding protein TYPA
C1H56_RS12645	COG0174	glutamine synthetase
C1H56_RS12655	COG3852	Histidine kinase
C1H56_RS12665	COG5001	Diguanylate cyclase
C1H56_RS12665	COG3300	MHYT domain
C1H56_RS12670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1H56_RS12740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1H56_RS12745	COG1404	Belongs to the peptidase S8 family
C1H56_RS12750	COG4206	TonB-dependent receptor
C1H56_RS12755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1H56_RS12775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1H56_RS12780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1H56_RS12785	COG2177	Part of the ABC transporter FtsEX involved in
C1H56_RS12790	COG2884	Cell division ATP-binding protein ftsE
C1H56_RS12795	COG0552	protein localization to endoplasmic reticulum
C1H56_RS12800	COG0742	ribosomal rna small subunit methyltransferase
C1H56_RS12840	COG0783	Belongs to the Dps family
C1H56_RS12845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1H56_RS12850	COG1280	lysine exporter protein (LysE YggA)
C1H56_RS12855	COG2267	carboxylic ester hydrolase activity
C1H56_RS12860	COG0561	phosphatase activity
C1H56_RS12880	COG3287	FIST C domain
C1H56_RS12880	COG2199	diguanylate cyclase activity
C1H56_RS12880	COG2200	EAL domain
C1H56_RS12885	COG1011	Hydrolase
C1H56_RS12890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C1H56_RS12900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1H56_RS12905	COG0019	diaminopimelate decarboxylase activity
C1H56_RS12915	COG1965	Belongs to the frataxin family
C1H56_RS12930	COG0181	hydroxymethylbilane synthase activity
C1H56_RS12935	COG1587	Uroporphyrinogen-III synthase
C1H56_RS12940	COG2959	enzyme of heme biosynthesis
C1H56_RS12945	COG3071	HemY protein
C1H56_RS12960	COG3078	GTPase activator activity
C1H56_RS12980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1H56_RS12980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1H56_RS12995	COG0084	hydrolase, TatD family'
C1H56_RS13005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1H56_RS13015	COG0840	transmembrane signaling receptor activity
C1H56_RS13020	COG1580	Controls the rotational direction of flagella during chemotaxis
C1H56_RS13030	COG3161	chorismate lyase activity
C1H56_RS13035	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1H56_RS13050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1H56_RS13060	COG0534	Mate efflux family protein
C1H56_RS13065	COG1858	cytochrome C peroxidase
C1H56_RS13070	COG0805	protein transport
C1H56_RS13075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1H56_RS13080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1H56_RS13095	COG2226	methyltransferase
C1H56_RS13100	COG1322	Protein conserved in bacteria
C1H56_RS13110	COG2081	HI0933 family
C1H56_RS13120	COG1528	Iron-storage protein
C1H56_RS13130	COG0589	response to stress
C1H56_RS13150	COG5001	Diguanylate cyclase
C1H56_RS13150	COG5002	protein histidine kinase activity
C1H56_RS13155	COG1522	sequence-specific DNA binding
C1H56_RS13175	COG0006	proline dipeptidase activity
C1H56_RS13175	COG0006	proline dipeptidase activity
C1H56_RS13180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1H56_RS13185	COG2022	thiamine diphosphate biosynthetic process
C1H56_RS13190	COG2104	thiamine diphosphate biosynthetic process
C1H56_RS13195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1H56_RS13205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1H56_RS13210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1H56_RS13260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1H56_RS13275	COG3118	belongs to the thioredoxin family
C1H56_RS13280	COG0513	Belongs to the DEAD box helicase family
C1H56_RS13285	COG0248	Ppx GppA phosphatase
C1H56_RS13290	COG0784	Response regulator, receiver
C1H56_RS13290	COG2205	protein histidine kinase activity
C1H56_RS13295	COG2814	Major facilitator Superfamily
C1H56_RS13315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1H56_RS13320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1H56_RS13325	COG0511	ligase activity, forming carbon-carbon bonds
C1H56_RS13330	COG0439	Biotin carboxylase
C1H56_RS13335	COG2264	protein methyltransferase activity
C1H56_RS13340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1H56_RS13345	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1H56_RS13350	COG1609	Transcriptional regulator
C1H56_RS13355	COG0129	dihydroxy-acid dehydratase activity
C1H56_RS13360	COG3265	gluconokinase activity
C1H56_RS13370	COG0800	Aldolase
C1H56_RS13390	COG0840	transmembrane signaling receptor activity
C1H56_RS13395	COG1982	Orn Lys Arg decarboxylase major
C1H56_RS13400	COG0531	amino acid
C1H56_RS13405	COG3710	Transcriptional regulator
C1H56_RS13410	COG0789	Transcriptional regulator
C1H56_RS13425	COG0151	Belongs to the GarS family
C1H56_RS13435	COG0776	regulation of translation
C1H56_RS13440	COG1253	flavin adenine dinucleotide binding
C1H56_RS13445	COG1940	carbohydrate kinase activity
C1H56_RS13455	COG3068	Protein conserved in bacteria
C1H56_RS13465	COG1573	uracil-dna glycosylase
C1H56_RS13470	COG0668	transmembrane transport
C1H56_RS13475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C1H56_RS13480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1H56_RS13530	COG1454	alcohol dehydrogenase
C1H56_RS13530	COG1012	belongs to the aldehyde dehydrogenase family
C1H56_RS13535	COG0318	PFAM AMP-dependent synthetase and ligase
C1H56_RS13565	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1H56_RS13570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1H56_RS13575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C1H56_RS13575	COG0662	Cupin 2, conserved barrel domain protein
C1H56_RS13580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1H56_RS13615	COG1519	Transferase
C1H56_RS13645	COG3642	lipopolysaccharide core region biosynthetic process
C1H56_RS13650	COG0859	PFAM glycosyl transferase family 9
C1H56_RS13655	COG0463	Glycosyl transferase, family 2
C1H56_RS13660	COG0859	PFAM glycosyl transferase family 9
C1H56_RS13665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1H56_RS13670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1H56_RS13680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1H56_RS13685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1H56_RS13690	COG2003	Belongs to the UPF0758 family
C1H56_RS13700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1H56_RS13710	COG1309	transcriptional regulator
C1H56_RS13715	COG1560	Kdo2-lipid A biosynthetic process
C1H56_RS13720	COG1560	Kdo2-lipid A biosynthetic process
C1H56_RS13725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1H56_RS13730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1H56_RS13735	COG1561	YicC-like family, N-terminal region
C1H56_RS13740	COG2862	Uncharacterized protein family, UPF0114
C1H56_RS13745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H56_RS13745	COG1263	PTS System
C1H56_RS13750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1H56_RS13775	COG1120	ATPase activity
C1H56_RS13780	COG4774	siderophore transport
C1H56_RS13785	COG1132	(ABC) transporter
C1H56_RS13800	COG0514	ATP-dependent DNA helicase (RecQ)
C1H56_RS13805	COG2962	Rard protein
C1H56_RS13820	COG1280	lysine exporter protein (LysE YggA)
C1H56_RS13835	COG0210	DNA helicase
C1H56_RS13845	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1H56_RS13850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1H56_RS13900	COG3621	Patatin-like phospholipase
C1H56_RS13925	COG2131	deaminase
C1H56_RS13935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1H56_RS13940	COG0601	transmembrane transport
C1H56_RS13945	COG0747	negative chemotaxis
C1H56_RS14000	COG1309	transcriptional regulator
C1H56_RS14005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1H56_RS14010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1H56_RS14015	COG2960	long-chain fatty acid transporting porin activity
C1H56_RS14020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1H56_RS14025	COG0583	DNA-binding transcription factor activity
C1H56_RS14070	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C1H56_RS14075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1H56_RS14080	COG1739	Uncharacterized protein family UPF0029
C1H56_RS14090	COG0183	Belongs to the thiolase family
C1H56_RS14095	COG0583	DNA-binding transcription factor activity
C1H56_RS14100	COG2814	Major facilitator Superfamily
C1H56_RS14105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1H56_RS14110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1H56_RS14115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1H56_RS14120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1H56_RS14125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1H56_RS14130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1H56_RS14135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1H56_RS14145	COG0356	it plays a direct role in the translocation of protons across the membrane
C1H56_RS14150	COG3312	ion transport
C1H56_RS14155	COG1475	DNA binding
C1H56_RS14160	COG1192	Involved in chromosome partitioning
C1H56_RS14170	COG0445	tRNA wobble uridine modification
C1H56_RS14180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1H56_RS14185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1H56_RS14190	COG0706	membrane insertase activity
C1H56_RS14200	COG0594	ribonuclease P activity
C1H56_RS14205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1H56_RS14210	COG1126	abc transporter atp-binding protein
C1H56_RS14245	COG0217	transcriptional regulatory protein
C1H56_RS14250	COG2084	Dehydrogenase
C1H56_RS14270	COG2909	trisaccharide binding
C1H56_RS14275	COG0058	SHG alpha-glucan phosphorylase activity
C1H56_RS14280	COG1640	4-alpha-glucanotransferase
C1H56_RS14285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1H56_RS14300	COG3501	Rhs element vgr protein
C1H56_RS14305	COG4104	PAAR repeat-containing protein
C1H56_RS14335	COG0471	metal ion transport
C1H56_RS14340	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1H56_RS14385	COG0671	phosphoesterase, PA-phosphatase related
C1H56_RS14390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1H56_RS14400	COG1999	signal sequence binding
C1H56_RS14415	COG0786	glutamate:sodium symporter activity
C1H56_RS14435	COG1566	PFAM secretion protein HlyD family protein
C1H56_RS14460	COG0813	purine-nucleoside phosphorylase activity
C1H56_RS14470	COG3272	Protein of unknown function (DUF1722)
C1H56_RS14480	COG0415	Belongs to the DNA photolyase family
C1H56_RS14485	COG1388	LysM domain
C1H56_RS14485	COG1376	ErfK ybiS ycfS ynhG family protein
C1H56_RS14495	COG0513	Belongs to the DEAD box helicase family
C1H56_RS14500	COG1770	oligopeptidase
C1H56_RS14530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1H56_RS14535	COG0573	inorganic phosphate transmembrane transporter activity
C1H56_RS14540	COG0581	inorganic phosphate transmembrane transporter activity
C1H56_RS14545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1H56_RS14565	COG3314	Sporulation integral membrane protein YlbJ
C1H56_RS14570	COG0659	secondary active sulfate transmembrane transporter activity
C1H56_RS14580	COG0739	heme binding
C1H56_RS14585	COG5001	Diguanylate cyclase
C1H56_RS14585	COG3300	MHYT domain
C1H56_RS14590	COG0583	DNA-binding transcription factor activity
C1H56_RS14595	COG2814	Major facilitator Superfamily
C1H56_RS14620	COG1301	dicarboxylic acid transport
C1H56_RS14630	COG1342	Belongs to the UPF0251 family
C1H56_RS14665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1H56_RS14670	COG0673	inositol 2-dehydrogenase activity
C1H56_RS14680	COG2200	EAL domain
C1H56_RS14680	COG2771	luxR family
C1H56_RS14685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1H56_RS14695	COG0564	pseudouridine synthase activity
C1H56_RS14760	COG3829	transcription factor binding
C1H56_RS14790	COG3501	Rhs element vgr protein
C1H56_RS14790	COG3409	Peptidoglycan-binding domain 1 protein
C1H56_RS14805	COG1869	D-ribose catabolic process
C1H56_RS14810	COG1129	ABC transporter
C1H56_RS14815	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1H56_RS14820	COG1879	ABC-type sugar transport system periplasmic component
C1H56_RS14825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1H56_RS14830	COG1609	Transcriptional regulator
C1H56_RS14840	COG3201	nicotinamide mononucleotide transporter
C1H56_RS14845	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1H56_RS14855	COG0584	glycerophosphoryl diester phosphodiesterase
C1H56_RS14860	COG2271	Major facilitator Superfamily
C1H56_RS14900	COG0579	oxidoreductase
C1H56_RS14910	COG0242	peptide deformylase activity
C1H56_RS14920	COG1320	monovalent cation:proton antiporter activity
C1H56_RS14925	COG2212	antiporter activity
C1H56_RS14930	COG1863	multisubunit Na H antiporter MnhE subunit
C1H56_RS14935	COG0651	ATP synthesis coupled electron transport
C1H56_RS14940	COG1006	Multisubunit Na H antiporter MnhC subunit
C1H56_RS14945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1H56_RS14945	COG2111	Na H antiporter
C1H56_RS14955	COG0589	response to stress
C1H56_RS14960	COG0814	amino acid
C1H56_RS14975	COG3530	Putative quorum-sensing-regulated virulence factor
C1H56_RS14985	COG5002	protein histidine kinase activity
C1H56_RS14985	COG5001	Diguanylate cyclase
C1H56_RS14990	COG1278	Cold shock
C1H56_RS15005	COG2304	oxidoreductase activity
C1H56_RS15025	COG0714	Associated with various cellular activities
C1H56_RS15030	COG0840	transmembrane signaling receptor activity
C1H56_RS15045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1H56_RS15050	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1H56_RS15060	COG3604	Transcriptional regulator
C1H56_RS15065	COG1017	nitric oxide dioxygenase activity
C1H56_RS15065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1H56_RS15070	COG1278	Cold shock
C1H56_RS15075	COG3036	rescue of stalled ribosome
C1H56_RS15100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1H56_RS15100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1H56_RS15105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1H56_RS15115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1H56_RS15130	COG0516	GMP reductase activity
C1H56_RS15170	COG0513	Belongs to the DEAD box helicase family
C1H56_RS15175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1H56_RS15180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1H56_RS15185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1H56_RS15195	COG0784	Response regulator, receiver
C1H56_RS15195	COG3437	response regulator, receiver
C1H56_RS15200	COG4191	Histidine kinase
C1H56_RS15200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H56_RS15210	COG1757	Na H antiporter
C1H56_RS15215	COG2814	Major facilitator Superfamily
C1H56_RS15225	COG3706	GGDEF domain
C1H56_RS15230	COG3240	lipase activity
C1H56_RS15240	COG0840	transmembrane signaling receptor activity
C1H56_RS15245	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1H56_RS15250	COG5380	lipid catabolic process
C1H56_RS15275	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1H56_RS15280	COG4605	iron ion homeostasis
C1H56_RS15285	COG4604	ABC transporter, ATP-binding protein
C1H56_RS15290	COG2207	Transcriptional regulator
C1H56_RS15305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1H56_RS15325	COG0745	RESPONSE REGULATOR receiver
C1H56_RS15335	COG3623	hexulose-6-phosphate isomerase
C1H56_RS15340	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C1H56_RS15345	COG0561	phosphatase activity
C1H56_RS15375	COG3038	cytochrome b561
C1H56_RS15380	COG0366	Alpha amylase catalytic
C1H56_RS15405	COG0745	RESPONSE REGULATOR receiver
C1H56_RS15410	COG5002	protein histidine kinase activity
C1H56_RS15435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1H56_RS15450	COG2814	Major facilitator Superfamily
C1H56_RS15465	COG1686	Belongs to the peptidase S11 family
C1H56_RS15495	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1H56_RS15495	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1H56_RS15500	COG0509	glycine decarboxylation via glycine cleavage system
C1H56_RS15505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1H56_RS15515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1H56_RS15525	COG3039	Transposase
C1H56_RS15560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1H56_RS15565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1H56_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
C1H56_RS15675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1H56_RS15705	COG0494	nUDIX hydrolase
C1H56_RS15730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1H56_RS15735	COG3040	lipid binding
C1H56_RS15765	COG3041	Addiction module toxin RelE StbE family
C1H56_RS15870	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1H56_RS15925	COG0346	lactoylglutathione lyase activity
C1H56_RS15940	COG3040	lipid binding
C1H56_RS15960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C1H56_RS15970	COG1280	lysine exporter protein (LysE YggA)
C1H56_RS16200	COG3549	Plasmid maintenance system killer
C1H56_RS16205	COG3093	addiction module antidote protein HigA
C1H56_RS16230	COG0384	phenazine biosynthesis protein PhzF
C1H56_RS16265	COG0346	lactoylglutathione lyase activity
C1H56_RS16305	COG3040	lipid binding
C1H56_RS16365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1H56_RS16395	COG0384	phenazine biosynthesis protein PhzF
C1H56_RS16495	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1H56_RS16520	COG3040	lipid binding
C1H56_RS16590	COG4977	sequence-specific DNA binding
C1H56_RS16700	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C1H56_RS16705	COG2944	sequence-specific DNA binding
C1H56_RS16715	COG3039	Transposase
C1H56_RS16720	COG0110	maltose O-acetyltransferase activity
C1H56_RS16740	COG0346	lactoylglutathione lyase activity
C1H56_RS16905	COG0346	lactoylglutathione lyase activity
C1H56_RS16925	COG1328	CTP reductase activity
C1H56_RS16930	COG0602	queuosine metabolic process
C1H56_RS16940	COG4067	protein conserved in archaea
C1H56_RS16940	COG0189	ligase activity
C1H56_RS16945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H56_RS16945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1H56_RS16945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1H56_RS16950	COG1105	Belongs to the carbohydrate kinase PfkB family
C1H56_RS16955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H56_RS16955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H56_RS16960	COG1609	Transcriptional regulator
C1H56_RS16965	COG0420	3'-5' exonuclease activity
C1H56_RS16970	COG0419	ATPase involved in DNA repair
C1H56_RS16975	COG2205	protein histidine kinase activity
C1H56_RS16975	COG0784	Response regulator, receiver
C1H56_RS16985	COG0156	8-amino-7-oxononanoate synthase activity
C1H56_RS17000	COG0523	cobalamin synthesis protein
C1H56_RS17015	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1H56_RS17015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1H56_RS17015	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1H56_RS17015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1H56_RS17020	COG2205	protein histidine kinase activity
C1H56_RS17025	COG0745	RESPONSE REGULATOR receiver
C1H56_RS17030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1H56_RS17035	COG0586	Pfam SNARE associated Golgi protein
C1H56_RS17045	COG2200	EAL domain
C1H56_RS17055	COG3038	cytochrome b561
C1H56_RS17065	COG2116	formate transmembrane transporter activity
C1H56_RS17070	COG0583	DNA-binding transcription factor activity
C1H56_RS17080	COG3593	DNA synthesis involved in DNA repair
C1H56_RS17085	COG0737	Belongs to the 5'-nucleotidase family
C1H56_RS17100	COG2824	Alkylphosphonate utilization operon protein PhnA
C1H56_RS17135	COG2199	diguanylate cyclase activity
C1H56_RS17155	COG3706	GGDEF domain
C1H56_RS17170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1H56_RS17175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1H56_RS17185	COG0745	RESPONSE REGULATOR receiver
C1H56_RS17200	COG3140	Belongs to the UPF0181 family
C1H56_RS17205	COG0023	Translation Initiation Factor
C1H56_RS17225	COG0045	succinate-CoA ligase (ADP-forming) activity
C1H56_RS17225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1H56_RS17225	COG1042	CoA-binding domain protein
C1H56_RS17230	COG0583	DNA-binding transcription factor activity
C1H56_RS17235	COG4771	TonB-dependent receptor
C1H56_RS17235	COG1629	transport
C1H56_RS17250	COG2050	protein possibly involved in aromatic compounds catabolism
C1H56_RS17275	COG0625	glutathione transferase activity
C1H56_RS17290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1H56_RS17295	COG4172	Belongs to the ABC transporter superfamily
C1H56_RS17300	COG4239	(ABC) transporter, permease
C1H56_RS17305	COG4174	ABC transporter (Permease)
C1H56_RS17310	COG4166	transmembrane transport
C1H56_RS17335	COG3104	oligopeptide transport
C1H56_RS17355	COG3842	ATPase activity
C1H56_RS17365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1H56_RS17370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1H56_RS17375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1H56_RS17380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1H56_RS17385	COG1011	Hydrolase
C1H56_RS17395	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1H56_RS17400	COG1970	mechanosensitive ion channel activity
C1H56_RS17405	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1H56_RS17410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H56_RS17410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1H56_RS17415	COG0302	gtp cyclohydrolase
C1H56_RS17425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1H56_RS17435	COG2897	thiosulfate sulfurtransferase activity
C1H56_RS17440	COG2390	Transcriptional regulator
C1H56_RS17455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1H56_RS17480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1H56_RS17505	COG0583	DNA-binding transcription factor activity
C1H56_RS17510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C1H56_RS17555	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1H56_RS17600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1H56_RS17600	COG1263	PTS System
C1H56_RS17605	COG1609	Transcriptional regulator
C1H56_RS17610	COG1621	beta-fructofuranosidase activity
C1H56_RS17615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1H56_RS17620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1H56_RS17630	COG2885	chlorophyll binding
C1H56_RS17635	COG0545	Peptidyl-prolyl cis-trans isomerase
C1H56_RS17640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1H56_RS17645	COG0840	transmembrane signaling receptor activity
C1H56_RS17655	COG3069	C4-dicarboxylate transmembrane transporter activity
C1H56_RS17660	COG1760	l-serine dehydratase
C1H56_RS17680	COG1609	Transcriptional regulator
C1H56_RS17685	COG2197	response regulator
C1H56_RS17690	COG3850	Histidine kinase
C1H56_RS17695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1H56_RS17705	COG0243	molybdopterin cofactor binding
C1H56_RS17725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1H56_RS17730	COG2197	response regulator
C1H56_RS17735	COG3851	Histidine kinase
C1H56_RS17740	COG2271	Major facilitator Superfamily
C1H56_RS17745	COG1840	ABC-type Fe3 transport system, periplasmic component
C1H56_RS17755	COG3842	ATPase activity
C1H56_RS17760	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1H56_RS17770	COG0183	Belongs to the thiolase family
C1H56_RS17780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1H56_RS17785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1H56_RS17805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1H56_RS17815	COG1979	alcohol dehydrogenase
C1H56_RS17830	COG4191	Histidine kinase
C1H56_RS17840	COG2271	Major facilitator Superfamily
C1H56_RS17845	COG0469	pyruvate kinase activity
C1H56_RS17850	COG0784	Response regulator, receiver
C1H56_RS17850	COG2198	Histidine kinase
C1H56_RS17850	COG2205	protein histidine kinase activity
C1H56_RS17855	COG1879	ABC-type sugar transport system periplasmic component
C1H56_RS17860	COG1803	Methylglyoxal synthase
C1H56_RS17865	COG1335	isochorismatase
C1H56_RS17870	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1H56_RS17885	COG0210	DNA helicase
C1H56_RS17890	COG1289	transmembrane transporter activity
C1H56_RS17920	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1H56_RS17925	COG4149	molybdate abc transporter
C1H56_RS17930	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1H56_RS17935	COG1492	cobalamin metabolic process
C1H56_RS17980	COG5002	protein histidine kinase activity
C1H56_RS17980	COG0784	Response regulator, receiver
C1H56_RS17985	COG1879	ABC-type sugar transport system periplasmic component
C1H56_RS17995	COG2827	Endonuclease containing a URI domain
C1H56_RS18010	COG2926	Belongs to the UPF0265 family
C1H56_RS18025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1H56_RS18030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1H56_RS18035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1H56_RS18040	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1H56_RS18045	COG0247	lactate metabolic process
C1H56_RS18050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1H56_RS18055	COG3118	belongs to the thioredoxin family
C1H56_RS18085	COG0583	DNA-binding transcription factor activity
C1H56_RS18090	COG4160	amino acid transport
C1H56_RS18095	COG4215	(ABC) transporter
C1H56_RS18100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H56_RS18105	COG1126	abc transporter atp-binding protein
C1H56_RS18115	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C1H56_RS18125	COG0494	nUDIX hydrolase
C1H56_RS18130	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C1H56_RS18140	COG1309	transcriptional regulator
C1H56_RS18145	COG0513	Belongs to the DEAD box helicase family
C1H56_RS18150	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C1H56_RS18160	COG0814	amino acid
C1H56_RS18165	COG0840	transmembrane signaling receptor activity
C1H56_RS18170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1H56_RS18180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1H56_RS18190	COG1984	allophanate hydrolase subunit 2
C1H56_RS18205	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1H56_RS18210	COG4181	ATPase activity
C1H56_RS18220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1H56_RS18225	COG5001	Diguanylate cyclase
C1H56_RS18225	COG1716	ATPase activity
C1H56_RS18240	COG0484	heat shock protein binding
C1H56_RS18280	COG0546	phosphoglycolate phosphatase activity
C1H56_RS18295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1H56_RS18300	COG1368	sulfuric ester hydrolase activity
C1H56_RS18310	COG0513	Belongs to the DEAD box helicase family
C1H56_RS18325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1H56_RS18335	COG3046	protein related to deoxyribodipyrimidine photolyase
C1H56_RS18340	COG3397	chitin binding
C1H56_RS18345	COG3227	Zinc metalloprotease (Elastase)
C1H56_RS18355	COG0010	Belongs to the arginase family
C1H56_RS18360	COG1166	arginine decarboxylase activity
C1H56_RS18370	COG2239	Acts as a magnesium transporter
C1H56_RS18375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1H56_RS18380	COG0459	protein refolding
C1H56_RS18390	COG0527	aspartate kinase activity
C1H56_RS18395	COG0662	Cupin 2, conserved barrel domain protein
C1H56_RS18400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1H56_RS18405	COG0456	acetyltransferase
C1H56_RS18415	COG3186	Phenylalanine-4-hydroxylase
C1H56_RS18420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1H56_RS18440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1H56_RS18465	COG1253	flavin adenine dinucleotide binding
C1H56_RS18470	COG1765	OsmC-like protein
C1H56_RS18495	COG0531	amino acid
C1H56_RS18510	COG3279	Response regulator of the LytR AlgR family
C1H56_RS18515	COG3275	phosphorelay sensor kinase activity
C1H56_RS18530	COG1136	(ABC) transporter
C1H56_RS18530	COG0577	efflux transmembrane transporter activity
C1H56_RS18535	COG1136	(ABC) transporter
C1H56_RS18550	COG4989	oxidoreductase activity
C1H56_RS18555	COG0366	Alpha amylase catalytic
C1H56_RS18565	COG2067	long-chain fatty acid transport protein
C1H56_RS18570	COG2267	carboxylic ester hydrolase activity
C1H56_RS18580	COG3227	Zinc metalloprotease (Elastase)
C1H56_RS18590	COG3047	cAMP biosynthetic process
C1H56_RS18600	COG1686	Belongs to the peptidase S11 family
C1H56_RS18605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1H56_RS18610	COG1271	oxidase subunit
C1H56_RS18615	COG1294	oxidase, subunit
C1H56_RS18635	COG3048	D-serine ammonia-lyase activity
C1H56_RS18640	COG0583	DNA-binding transcription factor activity
C1H56_RS18690	COG1063	alcohol dehydrogenase
C1H56_RS18720	COG0346	lactoylglutathione lyase activity
C1H56_RS18740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1H56_RS18745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1H56_RS18750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1H56_RS18755	COG0363	glucosamine-6-phosphate deaminase activity
C1H56_RS18760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1H56_RS18785	COG1929	Belongs to the glycerate kinase type-1 family
C1H56_RS18790	COG2610	gluconate transmembrane transporter activity
C1H56_RS18795	COG3835	regulator
C1H56_RS18805	COG0748	coenzyme F420 binding
C1H56_RS18810	COG3721	Heme iron utilization protein
C1H56_RS18820	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1H56_RS18825	COG0811	peptide transport
C1H56_RS18830	COG0848	biopolymer transport protein
C1H56_RS18835	COG4558	Periplasmic binding protein
C1H56_RS18840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1H56_RS18845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1H56_RS18880	COG0633	Ferredoxin
C1H56_RS18880	COG3217	Mosc domain protein beta barrel domain protein
C1H56_RS18880	COG0633	Ferredoxin
C1H56_RS18880	COG3217	Mosc domain protein beta barrel domain protein
C1H56_RS18890	COG0418	dihydroorotase activity
C1H56_RS18900	COG3152	Membrane
C1H56_RS18910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1H56_RS18915	COG2354	Protein conserved in bacteria
C1H56_RS18920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1H56_RS18925	COG1278	Cold shock
C1H56_RS18945	COG2207	Transcriptional regulator
C1H56_RS18945	COG4753	response regulator
C1H56_RS18955	COG2199	diguanylate cyclase activity
C1H56_RS18960	COG1349	DNA-binding transcription factor activity
C1H56_RS18975	COG3833	ABC-type maltose transport systems, permease component
C1H56_RS18980	COG1175	transmembrane transport
C1H56_RS18990	COG3842	ATPase activity
C1H56_RS18995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1H56_RS19010	COG0393	Putative heavy-metal-binding
C1H56_RS19020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1H56_RS19025	COG0784	Response regulator, receiver
C1H56_RS19025	COG0835	chemotaxis
C1H56_RS19030	COG1846	Transcriptional regulator
C1H56_RS19035	COG3706	GGDEF domain
C1H56_RS19075	COG0583	DNA-binding transcription factor activity
C1H56_RS19080	COG5001	Diguanylate cyclase
C1H56_RS19090	COG1741	Belongs to the pirin family
C1H56_RS19095	COG3123	guanosine phosphorylase activity
C1H56_RS19105	COG2211	Major facilitator Superfamily
C1H56_RS19115	COG0840	transmembrane signaling receptor activity
C1H56_RS19120	COG1067	ATP-dependent peptidase activity
C1H56_RS19130	COG4172	Belongs to the ABC transporter superfamily
C1H56_RS19155	COG0583	DNA-binding transcription factor activity
C1H56_RS19160	COG1620	l-lactate permease
C1H56_RS19175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C1H56_RS19185	COG0840	transmembrane signaling receptor activity
C1H56_RS19195	COG0513	Belongs to the DEAD box helicase family
C1H56_RS19200	COG0583	DNA-binding transcription factor activity
C1H56_RS19210	COG1902	pentaerythritol trinitrate reductase activity
C1H56_RS19220	COG1132	(ABC) transporter
C1H56_RS19230	COG1902	pentaerythritol trinitrate reductase activity
C1H56_RS19240	COG1280	lysine exporter protein (LysE YggA)
C1H56_RS19245	COG2207	Transcriptional regulator
C1H56_RS19265	COG1846	Transcriptional regulator
C1H56_RS19270	COG1764	response to oxidative stress
C1H56_RS19275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C1H56_RS19280	COG0697	spore germination
C1H56_RS19290	COG0700	Nucleoside recognition
C1H56_RS19295	COG3366	ferrous iron transmembrane transporter activity
C1H56_RS19300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C1H56_RS19310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1H56_RS19315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C1H56_RS19320	COG2259	Doxx family
C1H56_RS19345	COG0363	glucosamine-6-phosphate deaminase activity
C1H56_RS19360	COG4580	involved in the transport of maltose and maltodextrins
C1H56_RS19375	COG0840	transmembrane signaling receptor activity
C1H56_RS19390	COG0840	transmembrane signaling receptor activity
C1H56_RS19400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1H56_RS19405	COG1126	abc transporter atp-binding protein
C1H56_RS19415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1H56_RS19420	COG4597	amino acid ABC transporter
C1H56_RS19425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1H56_RS19435	COG0739	heme binding
C1H56_RS19445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1H56_RS19445	COG2213	PTS system mannitol-specific
C1H56_RS19450	COG0246	Mannitol dehydrogenase
C1H56_RS19455	COG3722	fumarate hydratase activity
C1H56_RS19460	COG0673	inositol 2-dehydrogenase activity
C1H56_RS19490	COG2910	NAD(P)H-binding
C1H56_RS19500	COG0840	transmembrane signaling receptor activity
C1H56_RS19510	COG4221	oxidoreductase activity
C1H56_RS19520	COG1901	pseudouridine methyltransferase
C1H56_RS19535	COG0531	amino acid
C1H56_RS19540	COG1982	Orn Lys Arg decarboxylase major
C1H56_RS19575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1H56_RS19600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1H56_RS19640	COG0745	RESPONSE REGULATOR receiver
C1H56_RS19665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1H56_RS19670	COG0840	transmembrane signaling receptor activity
C1H56_RS19675	COG0835	chemotaxis
C1H56_RS19680	COG0835	chemotaxis
C1H56_RS19685	COG2198	Histidine kinase
C1H56_RS19685	COG0643	Histidine kinase
C1H56_RS19705	COG0601	transmembrane transport
C1H56_RS19710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1H56_RS19720	COG2194	sulfuric ester hydrolase activity
C1H56_RS19725	COG0642	Histidine kinase
C1H56_RS19760	COG1444	tRNA N-acetyltransferase activity
C1H56_RS19765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine