locus-tag	class	description
GPY04_RS00010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY04_RS00015	COG0312	modulator of DNA gyrase
GPY04_RS00020	COG2235	arginine
GPY04_RS00040	COG0589	response to stress
GPY04_RS00055	COG1438	arginine binding
GPY04_RS00060	COG0039	L-malate dehydrogenase activity
GPY04_RS00065	COG0531	amino acid
GPY04_RS00070	COG0142	geranyltranstransferase activity
GPY04_RS00075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY04_RS00080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY04_RS00085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY04_RS00090	COG2966	Psort location CytoplasmicMembrane, score
GPY04_RS00095	COG3610	response to peptide
GPY04_RS00105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY04_RS00110	COG2967	ApaG domain
GPY04_RS00115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY04_RS00120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY04_RS00125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY04_RS00130	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY04_RS00135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY04_RS00190	COG0741	lytic transglycosylase activity
GPY04_RS00195	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY04_RS00200	COG1194	a g-specific adenine glycosylase
GPY04_RS00205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY04_RS00210	COG2066	Belongs to the glutaminase family
GPY04_RS00215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY04_RS00220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY04_RS00230	COG1872	DUF167
GPY04_RS00235	COG0762	integral membrane protein
GPY04_RS00240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY04_RS00245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY04_RS00265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY04_RS00270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY04_RS00275	COG1678	Uncharacterized ACR, COG1678
GPY04_RS00280	COG0189	ligase activity
GPY04_RS00285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY04_RS00290	COG2356	endonuclease I
GPY04_RS00295	COG3091	SprT-like family
GPY04_RS00300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY04_RS00305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY04_RS00310	COG0583	DNA-binding transcription factor activity
GPY04_RS00315	COG4771	TonB-dependent receptor
GPY04_RS00320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY04_RS00325	COG0126	phosphoglycerate kinase activity
GPY04_RS00330	COG0191	fructose-bisphosphate aldolase activity
GPY04_RS00340	COG0668	transmembrane transport
GPY04_RS00345	COG1279	arginine transmembrane transporter activity
GPY04_RS00350	COG0583	DNA-binding transcription factor activity
GPY04_RS00360	COG0469	pyruvate kinase activity
GPY04_RS00365	COG1349	DNA-binding transcription factor activity
GPY04_RS00370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY04_RS00375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY04_RS00430	COG0328	RNA-DNA hybrid ribonuclease activity
GPY04_RS00455	COG0739	heme binding
GPY04_RS00490	COG2003	Belongs to the UPF0758 family
GPY04_RS00515	COG0582	viral genome integration into host DNA
GPY04_RS00525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY04_RS00530	COG0358	DNA primase activity
GPY04_RS00535	COG1610	YqeY-like protein
GPY04_RS00540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY04_RS00545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY04_RS00555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY04_RS00560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY04_RS00565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY04_RS00570	COG1968	undecaprenyl-diphosphatase activity
GPY04_RS00575	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY04_RS00580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY04_RS00585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY04_RS00590	COG0585	pseudouridine synthase activity
GPY04_RS00595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY04_RS00600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY04_RS00605	COG1388	LysM domain
GPY04_RS00605	COG4942	peptidase
GPY04_RS00610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY04_RS00615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY04_RS00635	COG4208	sulfate ABC transporter
GPY04_RS00640	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPY04_RS00650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY04_RS00655	COG2137	regulation of response to DNA damage stimulus
GPY04_RS00660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY04_RS00665	COG0527	aspartate kinase activity
GPY04_RS00670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPY04_RS00715	COG3630	sodium ion export across plasma membrane
GPY04_RS00720	COG5016	pyruvate
GPY04_RS00720	COG0511	ligase activity, forming carbon-carbon bonds
GPY04_RS00725	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY04_RS00735	COG1238	metal cluster binding
GPY04_RS00740	COG0612	Peptidase, M16
GPY04_RS00745	COG2918	glutathione biosynthetic process
GPY04_RS00750	COG1854	S-ribosylhomocysteine lyase activity
GPY04_RS00755	COG4536	flavin adenine dinucleotide binding
GPY04_RS00760	COG4137	Cytochrome C assembly protein
GPY04_RS00765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY04_RS00770	COG0228	four-way junction DNA binding
GPY04_RS00775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY04_RS00780	COG0336	Belongs to the RNA methyltransferase TrmD family
GPY04_RS00785	COG0335	large ribosomal subunit rRNA binding
GPY04_RS00790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY04_RS00795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY04_RS00805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY04_RS00810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY04_RS00815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY04_RS00820	COG0723	plastoquinol--plastocyanin reductase activity
GPY04_RS00825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY04_RS00830	COG2857	Cytochrome c1
GPY04_RS00835	COG0625	glutathione transferase activity
GPY04_RS00840	COG2969	positive regulation of protein catabolic process
GPY04_RS00845	COG2823	Periplasmic or secreted lipoprotein
GPY04_RS00850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY04_RS00855	COG0792	nuclease activity
GPY04_RS00860	COG3107	peptidoglycan biosynthetic process
GPY04_RS00865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY04_RS00880	COG0288	reversible hydration of carbon dioxide
GPY04_RS00885	COG0659	secondary active sulfate transmembrane transporter activity
GPY04_RS00890	COG1131	(ABC) transporter
GPY04_RS00895	COG0842	Transport permease protein
GPY04_RS00900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY04_RS00905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY04_RS00910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY04_RS00920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY04_RS00925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY04_RS00930	COG1489	DNA binding
GPY04_RS00940	COG1643	Atp-dependent helicase
GPY04_RS00945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY04_RS00950	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY04_RS00955	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY04_RS00960	COG3112	Uncharacterised protein family (UPF0231)
GPY04_RS00965	COG0347	Belongs to the P(II) protein family
GPY04_RS00970	COG0004	ammonium transporteR
GPY04_RS00975	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY04_RS00985	COG3842	ATPase activity
GPY04_RS01005	COG2971	BadF BadG BcrA BcrD
GPY04_RS01015	COG4608	Belongs to the ABC transporter superfamily
GPY04_RS01020	COG0444	Belongs to the ABC transporter superfamily
GPY04_RS01025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY04_RS01030	COG0601	transmembrane transport
GPY04_RS01035	COG0747	negative chemotaxis
GPY04_RS01045	COG2813	Specifically methylates the guanine in position
GPY04_RS01050	COG0628	permease
GPY04_RS01060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY04_RS01065	COG0316	Belongs to the HesB IscA family
GPY04_RS01080	COG0739	heme binding
GPY04_RS01085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY04_RS01090	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY04_RS01095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY04_RS01100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY04_RS01105	COG1534	Rna-binding protein
GPY04_RS01110	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY04_RS01115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY04_RS01120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY04_RS01125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY04_RS01130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY04_RS01145	COG0779	Required for maturation of 30S ribosomal subunits
GPY04_RS01150	COG0195	Participates in both transcription termination and antitermination
GPY04_RS01155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY04_RS01160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY04_RS01165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY04_RS01170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY04_RS01175	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY04_RS01180	COG4785	May be involved in cell division
GPY04_RS01215	COG3153	acetyltransferase
GPY04_RS01235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY04_RS01240	COG0513	Belongs to the DEAD box helicase family
GPY04_RS01245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY04_RS01260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY04_RS01265	COG2204	response regulator
GPY04_RS01280	COG0667	Aldo Keto reductase
GPY04_RS01285	COG3066	DNA modification
GPY04_RS01290	COG0494	nUDIX hydrolase
GPY04_RS01295	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPY04_RS01300	COG0730	response to heat
GPY04_RS01305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPY04_RS01310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY04_RS01315	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY04_RS01320	COG0583	DNA-binding transcription factor activity
GPY04_RS01325	COG0640	Transcriptional regulator
GPY04_RS01330	COG0268	Binds directly to 16S ribosomal RNA
GPY04_RS01335	COG0728	peptidoglycan biosynthetic process
GPY04_RS01340	COG0196	riboflavin kinase activity
GPY04_RS01345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY04_RS01350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY04_RS01355	COG1047	Peptidyl-prolyl cis-trans
GPY04_RS01360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY04_RS01365	COG1966	Carbon starvation protein
GPY04_RS01380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY04_RS01385	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY04_RS01390	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY04_RS01395	COG3279	Response regulator of the LytR AlgR family
GPY04_RS01400	COG3275	phosphorelay sensor kinase activity
GPY04_RS01405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY04_RS01410	COG0287	Prephenate dehydrogenase
GPY04_RS01410	COG1605	Chorismate mutase
GPY04_RS01420	COG0488	(ABC) transporter
GPY04_RS01430	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY04_RS01435	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY04_RS01440	COG5001	Diguanylate cyclase
GPY04_RS01445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY04_RS01450	COG0077	Prephenate dehydratase
GPY04_RS01450	COG1605	Chorismate mutase
GPY04_RS01455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY04_RS01460	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY04_RS01465	COG0564	pseudouridine synthase activity
GPY04_RS01475	COG0542	response to heat
GPY04_RS01515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY04_RS01525	COG2974	May be involved in recombination
GPY04_RS01530	COG0745	RESPONSE REGULATOR receiver
GPY04_RS01535	COG5002	protein histidine kinase activity
GPY04_RS01545	COG0248	Ppx GppA phosphatase
GPY04_RS01550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY04_RS01560	COG0581	inorganic phosphate transmembrane transporter activity
GPY04_RS01565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY04_RS01580	COG3142	Participates in the control of copper homeostasis
GPY04_RS01585	COG0450	alkyl hydroperoxide reductase
GPY04_RS01590	COG0583	DNA-binding transcription factor activity
GPY04_RS01595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY04_RS01605	COG0517	IMP dehydrogenase activity
GPY04_RS01610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY04_RS01615	COG0343	queuine tRNA-ribosyltransferase activity
GPY04_RS01620	COG1862	Preprotein translocase
GPY04_RS01625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY04_RS01630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY04_RS01635	COG0483	inositol monophosphate 1-phosphatase activity
GPY04_RS01645	COG1959	2 iron, 2 sulfur cluster binding
GPY04_RS01650	COG1104	cysteine desulfurase activity
GPY04_RS01655	COG0822	iron-sulfur transferase activity
GPY04_RS01665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY04_RS01670	COG0443	Heat shock 70 kDa protein
GPY04_RS01675	COG0633	Ferredoxin
GPY04_RS01680	COG2975	iron-sulfur cluster assembly
GPY04_RS01685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY04_RS01690	COG0105	UTP biosynthetic process
GPY04_RS01695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GPY04_RS01705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY04_RS01710	COG0124	histidyl-tRNA synthetase
GPY04_RS01715	COG2976	Protein conserved in bacteria
GPY04_RS01720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY04_RS01725	COG1160	GTP binding
GPY04_RS01740	COG1570	exodeoxyribonuclease VII activity
GPY04_RS01745	COG0517	IMP dehydrogenase activity
GPY04_RS01745	COG0516	GMP reductase activity
GPY04_RS01750	COG0519	Catalyzes the synthesis of GMP from XMP
GPY04_RS01750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY04_RS01760	COG1584	GPR1 FUN34 yaaH family protein
GPY04_RS01765	COG1535	isochorismatase
GPY04_RS01765	COG3433	isochorismatase activity
GPY04_RS01770	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY04_RS01775	COG1169	isochorismate synthase
GPY04_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
GPY04_RS01790	COG4592	Periplasmic binding protein
GPY04_RS01795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY04_RS01800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY04_RS01805	COG1120	ATPase activity
GPY04_RS01815	COG0583	DNA-binding transcription factor activity
GPY04_RS01820	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY04_RS01825	COG1115	amino acid carrier protein
GPY04_RS01830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY04_RS01835	COG0583	DNA-binding transcription factor activity
GPY04_RS01850	COG4565	transcriptional regulatory protein
GPY04_RS01860	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY04_RS01865	COG5016	pyruvate
GPY04_RS01865	COG0511	ligase activity, forming carbon-carbon bonds
GPY04_RS01870	COG3630	sodium ion export across plasma membrane
GPY04_RS01880	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPY04_RS01885	COG3052	prosthetic group binding
GPY04_RS01890	COG2301	Belongs to the HpcH HpaI aldolase family
GPY04_RS01895	COG3051	citrate lyase alpha subunit
GPY04_RS01900	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPY04_RS01905	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPY04_RS01915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY04_RS01920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY04_RS01925	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPY04_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
GPY04_RS02010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GPY04_RS02015	COG0840	transmembrane signaling receptor activity
GPY04_RS02020	COG3710	Transcriptional regulator
GPY04_RS02030	COG2165	general secretion pathway protein
GPY04_RS02045	COG4796	Type ii and iii secretion system protein
GPY04_RS02065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY04_RS02070	COG1459	type II secretion system
GPY04_RS02080	COG2207	Transcriptional regulator
GPY04_RS02085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GPY04_RS02105	COG0739	heme binding
GPY04_RS02115	COG3064	Membrane
GPY04_RS02120	COG0582	viral genome integration into host DNA
GPY04_RS02130	COG0582	viral genome integration into host DNA
GPY04_RS02140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY04_RS02145	COG2867	negative regulation of translational initiation
GPY04_RS02150	COG2914	Belongs to the UPF0125 (RnfH) family
GPY04_RS02155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY04_RS02160	COG0497	DNA recombination
GPY04_RS02165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY04_RS02170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY04_RS02175	COG0443	Heat shock 70 kDa protein
GPY04_RS02180	COG0484	heat shock protein binding
GPY04_RS02190	COG4968	Prepilin-type N-terminal cleavage methylation domain
GPY04_RS02215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY04_RS02220	COG0590	tRNA wobble adenosine to inosine editing
GPY04_RS02225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY04_RS02235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY04_RS02235	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY04_RS02240	COG1943	Transposase
GPY04_RS02260	COG0442	prolyl-tRNA aminoacylation
GPY04_RS02265	COG1720	tRNA m6t6A37 methyltransferase activity
GPY04_RS02270	COG0254	rRNA binding
GPY04_RS02275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY04_RS02280	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY04_RS02285	COG1671	Belongs to the UPF0178 family
GPY04_RS02295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY04_RS02310	COG3098	single-species biofilm formation
GPY04_RS02315	COG0564	pseudouridine synthase activity
GPY04_RS02320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY04_RS02325	COG0142	geranyltranstransferase activity
GPY04_RS02330	COG1722	exodeoxyribonuclease VII activity
GPY04_RS02335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY04_RS02345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY04_RS02345	COG0301	tRNA thio-modification
GPY04_RS02350	COG0583	DNA-binding transcription factor activity
GPY04_RS02355	COG2363	Small membrane protein
GPY04_RS02360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY04_RS02365	COG1611	Belongs to the LOG family
GPY04_RS02370	COG3706	GGDEF domain
GPY04_RS02380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY04_RS02380	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY04_RS02390	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY04_RS02395	COG1464	Belongs to the NlpA lipoprotein family
GPY04_RS02400	COG2011	ABC-type metal ion transport system permease component
GPY04_RS02405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY04_RS02410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY04_RS02415	COG1609	Transcriptional regulator
GPY04_RS02420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY04_RS02420	COG1263	PTS System
GPY04_RS02425	COG0366	Alpha amylase catalytic
GPY04_RS02455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY04_RS02460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY04_RS02465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY04_RS02470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY04_RS02475	COG0110	maltose O-acetyltransferase activity
GPY04_RS02495	COG1045	serine acetyltransferase
GPY04_RS02505	COG0438	transferase activity, transferring glycosyl groups
GPY04_RS02515	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPY04_RS02545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY04_RS02555	COG1596	polysaccharide export
GPY04_RS02580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY04_RS02590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY04_RS02595	COG0321	lipoyl(octanoyl) transferase activity
GPY04_RS02600	COG2921	Belongs to the UPF0250 family
GPY04_RS02605	COG1686	Belongs to the peptidase S11 family
GPY04_RS02610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY04_RS02615	COG0772	Belongs to the SEDS family
GPY04_RS02620	COG0768	penicillin binding
GPY04_RS02625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY04_RS02630	COG0799	negative regulation of ribosome biogenesis
GPY04_RS02635	COG1466	dna polymerase III delta subunit
GPY04_RS02640	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY04_RS02645	COG0495	leucyl-tRNA aminoacylation
GPY04_RS02650	COG2888	peptidyl-tyrosine sulfation
GPY04_RS02655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY04_RS02660	COG4535	Mg2 and Co2 transporter CorC
GPY04_RS02665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY04_RS02670	COG1702	phosphate starvation-inducible protein PhoH
GPY04_RS02675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY04_RS02680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY04_RS02685	COG2190	(PTS) system
GPY04_RS02695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY04_RS02705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY04_RS02710	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY04_RS02715	COG3115	cell septum assembly
GPY04_RS02720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY04_RS02735	COG0789	Transcriptional regulator
GPY04_RS02740	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPY04_RS02745	COG0330	HflC and HflK could
GPY04_RS02750	COG3118	belongs to the thioredoxin family
GPY04_RS02760	COG0300	oxidoreductase activity
GPY04_RS02765	COG1090	epimerase
GPY04_RS02770	COG0622	Phosphoesterase
GPY04_RS02785	COG3710	Transcriptional regulator
GPY04_RS02790	COG0326	Molecular chaperone. Has ATPase activity
GPY04_RS02795	COG0563	adenylate kinase activity
GPY04_RS02800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY04_RS02815	COG0367	asparagine synthase
GPY04_RS02820	COG4651	solute:proton antiporter activity
GPY04_RS02820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY04_RS02825	COG1940	carbohydrate kinase activity
GPY04_RS02825	COG1846	Transcriptional regulator
GPY04_RS02830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY04_RS02835	COG1263	PTS System
GPY04_RS02835	COG2190	(PTS) system
GPY04_RS02835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY04_RS02840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY04_RS02850	COG0101	tRNA pseudouridine synthase activity
GPY04_RS02855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY04_RS02860	COG0285	dihydrofolate synthase activity
GPY04_RS02865	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY04_RS02870	COG1286	toxin biosynthetic process
GPY04_RS02875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY04_RS02880	COG2056	Na+-H+ antiporter family
GPY04_RS02885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY04_RS02900	COG0346	lactoylglutathione lyase activity
GPY04_RS02905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY04_RS02910	COG4660	Part of a membrane complex involved in electron transport
GPY04_RS02915	COG4659	FMN binding
GPY04_RS02920	COG4658	electron transport chain
GPY04_RS02925	COG4656	Part of a membrane complex involved in electron transport
GPY04_RS02930	COG2878	Part of a membrane complex involved in electron transport
GPY04_RS02935	COG4657	Part of a membrane complex involved in electron transport
GPY04_RS02945	COG0556	nucleotide-excision repair
GPY04_RS02950	COG2204	response regulator
GPY04_RS02955	COG2198	Histidine kinase
GPY04_RS02960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY04_RS02965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY04_RS02970	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY04_RS02975	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY04_RS02980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY04_RS02985	COG0314	molybdopterin synthase activity
GPY04_RS02990	COG2199	diguanylate cyclase activity
GPY04_RS02995	COG4109	DRTGG domain
GPY04_RS03005	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY04_RS03015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY04_RS03015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY04_RS03020	COG0489	protein tyrosine kinase activity
GPY04_RS03025	COG0572	uridine kinase
GPY04_RS03030	COG2982	Protein involved in outer membrane biogenesis
GPY04_RS03035	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY04_RS03040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY04_RS03065	COG0183	Belongs to the thiolase family
GPY04_RS03070	COG1024	Enoyl-CoA hydratase
GPY04_RS03070	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY04_RS03075	COG0778	Nitroreductase
GPY04_RS03080	COG0583	DNA-binding transcription factor activity
GPY04_RS03085	COG0745	RESPONSE REGULATOR receiver
GPY04_RS03095	COG2832	Protein of unknown function (DUF454)
GPY04_RS03100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY04_RS03110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY04_RS03115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY04_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
GPY04_RS03135	COG0616	signal peptide processing
GPY04_RS03145	COG1522	sequence-specific DNA binding
GPY04_RS03150	COG1946	Acyl-CoA thioesterase
GPY04_RS03170	COG3706	GGDEF domain
GPY04_RS03180	COG0640	Transcriptional regulator
GPY04_RS03185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY04_RS03210	COG1881	PFAM PEBP family protein
GPY04_RS03230	COG0009	L-threonylcarbamoyladenylate synthase
GPY04_RS03245	COG2201	protein-glutamate methylesterase activity
GPY04_RS03255	COG5002	protein histidine kinase activity
GPY04_RS03260	COG4191	Histidine kinase
GPY04_RS03265	COG3300	MHYT domain
GPY04_RS03265	COG5001	Diguanylate cyclase
GPY04_RS03270	COG2204	response regulator
GPY04_RS03290	COG0601	transmembrane transport
GPY04_RS03295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY04_RS03300	COG0444	Belongs to the ABC transporter superfamily
GPY04_RS03305	COG4608	Belongs to the ABC transporter superfamily
GPY04_RS03310	COG0435	Glutathione S-transferase
GPY04_RS03315	COG0857	belongs to the CobB CobQ family
GPY04_RS03315	COG0280	phosphate acetyltransferase
GPY04_RS03320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY04_RS03325	COG3092	negative regulation of chromosome organization
GPY04_RS03330	COG4628	conserved protein (DUF2132)
GPY04_RS03340	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY04_RS03350	COG2199	diguanylate cyclase activity
GPY04_RS03350	COG2203	Gaf domain
GPY04_RS03355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY04_RS03365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY04_RS03370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY04_RS03375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY04_RS03380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY04_RS03385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY04_RS03390	COG0156	8-amino-7-oxononanoate synthase activity
GPY04_RS03395	COG2226	methyltransferase
GPY04_RS03400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY04_RS03410	COG0501	Belongs to the peptidase M48B family
GPY04_RS03420	COG0300	oxidoreductase activity
GPY04_RS03435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY04_RS03445	COG2268	Band 7 protein
GPY04_RS03455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY04_RS03460	COG2915	High frequency lysogenization protein hflD homolog
GPY04_RS03465	COG0482	sulfurtransferase activity
GPY04_RS03470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY04_RS03475	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY04_RS03480	COG1757	Na H antiporter
GPY04_RS03485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY04_RS03490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY04_RS03495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY04_RS03500	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY04_RS03500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY04_RS03505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY04_RS03510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY04_RS03515	COG0107	imidazoleglycerol-phosphate synthase activity
GPY04_RS03520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY04_RS03520	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY04_RS03525	COG1187	pseudouridine synthase activity
GPY04_RS03535	COG1278	Cold shock
GPY04_RS03540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY04_RS03545	COG0542	response to heat
GPY04_RS03555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY04_RS03560	COG1012	belongs to the aldehyde dehydrogenase family
GPY04_RS03560	COG1454	alcohol dehydrogenase
GPY04_RS03565	COG1737	Transcriptional regulator
GPY04_RS03570	COG0076	glutamate decarboxylase activity
GPY04_RS03580	COG2431	L-lysine efflux transmembrane transporter activity
GPY04_RS03590	COG3070	regulator of competence-specific genes
GPY04_RS03605	COG3852	Histidine kinase
GPY04_RS03615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY04_RS03635	COG0500	methyltransferase
GPY04_RS03640	COG4106	trans-aconitate 2-methyltransferase activity
GPY04_RS03645	COG1801	Protein of unknown function DUF72
GPY04_RS03650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPY04_RS03655	COG1435	thymidine kinase activity
GPY04_RS03665	COG0159	tryptophan synthase activity
GPY04_RS03670	COG0133	tryptophan synthase activity
GPY04_RS03675	COG0135	phosphoribosylanthranilate isomerase activity
GPY04_RS03675	COG0134	indole-3-glycerol-phosphate synthase activity
GPY04_RS03680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY04_RS03685	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY04_RS03690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY04_RS03700	COG0613	PHP domain protein
GPY04_RS03705	COG0009	L-threonylcarbamoyladenylate synthase
GPY04_RS03710	COG1187	pseudouridine synthase activity
GPY04_RS03715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY04_RS03720	COG4988	ABC transporter
GPY04_RS03725	COG0492	ferredoxin-NADP+ reductase activity
GPY04_RS03735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY04_RS03740	COG3706	GGDEF domain
GPY04_RS03745	COG2949	membrane
GPY04_RS03755	COG0281	malic enzyme
GPY04_RS03765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY04_RS03785	COG2885	chlorophyll binding
GPY04_RS03800	COG0277	FAD linked oxidase domain protein
GPY04_RS03800	COG0247	lactate metabolic process
GPY04_RS03820	COG2986	histidine ammonia-lyase
GPY04_RS03825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY04_RS03830	COG0010	Belongs to the arginase family
GPY04_RS03835	COG1228	amidohydrolase
GPY04_RS03855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY04_RS03865	COG5001	Diguanylate cyclase
GPY04_RS03870	COG0417	DNA replication proofreading
GPY04_RS03875	COG2197	response regulator
GPY04_RS03880	COG0322	excinuclease ABC activity
GPY04_RS03910	COG3706	GGDEF domain
GPY04_RS03910	COG0745	RESPONSE REGULATOR receiver
GPY04_RS03920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY04_RS03925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY04_RS03925	COG0072	phenylalanine-tRNA ligase activity
GPY04_RS03930	COG0776	regulation of translation
GPY04_RS03945	COG0500	methyltransferase
GPY04_RS03965	COG0295	cytidine deaminase activity
GPY04_RS03970	COG1346	cytolysis
GPY04_RS03980	COG2925	Exonuclease
GPY04_RS03990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY04_RS03995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY04_RS04000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY04_RS04015	COG2988	succinylglutamate desuccinylase activity
GPY04_RS04020	COG4139	cobalamin transport
GPY04_RS04025	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY04_RS04070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY04_RS04075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY04_RS04080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY04_RS04100	COG2814	Major facilitator Superfamily
GPY04_RS04110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY04_RS04135	COG2989	Protein conserved in bacteria
GPY04_RS04140	COG3108	Peptidase M15
GPY04_RS04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY04_RS04160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY04_RS04185	COG1846	Transcriptional regulator
GPY04_RS04190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY04_RS04195	COG0726	polysaccharide deacetylase
GPY04_RS04200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY04_RS04210	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY04_RS04215	COG1486	melibiose metabolic process
GPY04_RS04220	COG3394	polysaccharide catabolic process
GPY04_RS04225	COG1609	Transcriptional regulator
GPY04_RS04230	COG2943	transferase activity, transferring hexosyl groups
GPY04_RS04235	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPY04_RS04240	COG0840	transmembrane signaling receptor activity
GPY04_RS04255	COG1448	Aminotransferase
GPY04_RS04270	COG0351	phosphomethylpyrimidine kinase
GPY04_RS04275	COG0017	Asparaginyl-tRNA synthetase
GPY04_RS04285	COG0720	synthase
GPY04_RS04290	COG1760	l-serine dehydratase
GPY04_RS04295	COG0814	amino acid
GPY04_RS04300	COG0494	nUDIX hydrolase
GPY04_RS04305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY04_RS04320	COG3106	COG3106 Predicted ATPase
GPY04_RS04325	COG3768	UPF0283 membrane protein
GPY04_RS04330	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY04_RS04335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY04_RS04350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY04_RS04360	COG0471	metal ion transport
GPY04_RS04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY04_RS04365	COG4191	Histidine kinase
GPY04_RS04375	COG2990	Protein conserved in bacteria
GPY04_RS04380	COG3713	MltA-interacting MipA family protein
GPY04_RS04385	COG2205	protein histidine kinase activity
GPY04_RS04390	COG0745	RESPONSE REGULATOR receiver
GPY04_RS04415	COG1129	ABC transporter
GPY04_RS04450	COG2186	Transcriptional regulator
GPY04_RS04455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY04_RS04460	COG0372	Belongs to the citrate synthase family
GPY04_RS04495	COG1943	Transposase
GPY04_RS04500	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY04_RS04510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY04_RS04520	COG0625	glutathione transferase activity
GPY04_RS04525	COG3437	response regulator, receiver
GPY04_RS04540	COG3706	GGDEF domain
GPY04_RS04545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY04_RS04550	COG1254	Belongs to the acylphosphatase family
GPY04_RS04555	COG2920	part of a sulfur-relay system
GPY04_RS04560	COG0670	Belongs to the BI1 family
GPY04_RS04565	COG1126	abc transporter atp-binding protein
GPY04_RS04570	COG0765	amino acid transport
GPY04_RS04575	COG4597	amino acid ABC transporter
GPY04_RS04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY04_RS04590	COG0561	phosphatase activity
GPY04_RS04595	COG0602	queuosine metabolic process
GPY04_RS04600	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY04_RS04630	COG3706	GGDEF domain
GPY04_RS04635	COG0443	Heat shock 70 kDa protein
GPY04_RS04640	COG0443	Heat shock 70 kDa protein
GPY04_RS04675	COG1643	Atp-dependent helicase
GPY04_RS04685	COG0443	Heat shock 70 kDa protein
GPY04_RS04690	COG0095	Lipoate-protein ligase
GPY04_RS04700	COG0583	DNA-binding transcription factor activity
GPY04_RS04705	COG0477	Major facilitator Superfamily
GPY04_RS04710	COG0415	Belongs to the DNA photolyase family
GPY04_RS04715	COG2076	Multidrug Resistance protein
GPY04_RS04735	COG2198	Histidine kinase
GPY04_RS04735	COG0643	Histidine kinase
GPY04_RS04745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY04_RS04755	COG2201	protein-glutamate methylesterase activity
GPY04_RS04760	COG0835	chemotaxis
GPY04_RS04765	COG3290	protein histidine kinase activity
GPY04_RS04765	COG0840	transmembrane signaling receptor activity
GPY04_RS04770	COG0840	transmembrane signaling receptor activity
GPY04_RS04780	COG0513	Belongs to the DEAD box helicase family
GPY04_RS04790	COG1538	Outer membrane efflux protein
GPY04_RS04795	COG1566	PFAM secretion protein HlyD family protein
GPY04_RS04800	COG2814	Major facilitator Superfamily
GPY04_RS04805	COG0840	transmembrane signaling receptor activity
GPY04_RS04810	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY04_RS04820	COG3501	Rhs element vgr protein
GPY04_RS04845	COG1280	lysine exporter protein (LysE YggA)
GPY04_RS04850	COG1115	amino acid carrier protein
GPY04_RS04865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY04_RS04870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY04_RS04875	COG1177	transmembrane transport
GPY04_RS04880	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY04_RS04885	COG3842	ATPase activity
GPY04_RS04905	COG0037	tRNA processing
GPY04_RS04910	COG0589	response to stress
GPY04_RS04915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY04_RS04930	COG2217	Heavy metal translocating P-type atpase
GPY04_RS04940	COG2010	Cytochrome c
GPY04_RS04955	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY04_RS04970	COG2205	protein histidine kinase activity
GPY04_RS04970	COG0784	Response regulator, receiver
GPY04_RS04995	COG2994	toxin metabolic process
GPY04_RS05000	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GPY04_RS05000	COG1073	alpha beta
GPY04_RS05000	COG3064	Membrane
GPY04_RS05020	COG1476	TRANSCRIPTIONal
GPY04_RS05035	COG4128	Pfam Zonular occludens toxin
GPY04_RS05065	COG1476	TRANSCRIPTIONal
GPY04_RS05175	COG3120	sequence-specific DNA binding
GPY04_RS05180	COG1067	ATP-dependent peptidase activity
GPY04_RS05185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY04_RS05210	COG0116	Belongs to the methyltransferase superfamily
GPY04_RS05210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY04_RS05220	COG0167	dihydroorotate dehydrogenase activity
GPY04_RS05235	COG0308	aminopeptidase N
GPY04_RS05270	COG0641	radical SAM
GPY04_RS05350	COG4695	Portal protein
GPY04_RS05430	COG1428	Deoxynucleoside kinase
GPY04_RS05500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GPY04_RS05505	COG0308	aminopeptidase N
GPY04_RS05520	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY04_RS05525	COG1956	GAF domain-containing protein
GPY04_RS05530	COG1132	(ABC) transporter
GPY04_RS05535	COG2995	paraquat-inducible protein a
GPY04_RS05540	COG3008	intermembrane lipid transfer
GPY04_RS05545	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY04_RS05545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY04_RS05550	COG2996	Protein conserved in bacteria
GPY04_RS05565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY04_RS05575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY04_RS05590	COG0437	4 iron, 4 sulfur cluster binding
GPY04_RS05595	COG3383	formate dehydrogenase (NAD+) activity
GPY04_RS05595	COG0243	molybdopterin cofactor binding
GPY04_RS05625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY04_RS05630	COG0488	(ABC) transporter
GPY04_RS05635	COG3852	Histidine kinase
GPY04_RS05640	COG2204	response regulator
GPY04_RS05650	COG4662	Binding-protein-dependent transport system inner membrane component
GPY04_RS05655	COG3842	ATPase activity
GPY04_RS05660	COG0746	molybdenum cofactor guanylyltransferase activity
GPY04_RS05690	COG1940	carbohydrate kinase activity
GPY04_RS05705	COG0840	transmembrane signaling receptor activity
GPY04_RS05710	COG0791	NLP P60 protein
GPY04_RS05730	COG0534	Mate efflux family protein
GPY04_RS05740	COG1793	dna ligase
GPY04_RS05750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY04_RS05755	COG0848	biopolymer transport protein
GPY04_RS05760	COG0811	peptide transport
GPY04_RS05765	COG0811	peptide transport
GPY04_RS05780	COG1175	transmembrane transport
GPY04_RS05785	COG0395	ABC-type sugar transport system, permease component
GPY04_RS05790	COG3842	ATPase activity
GPY04_RS05795	COG1349	DNA-binding transcription factor activity
GPY04_RS05800	COG0584	glycerophosphoryl diester phosphodiesterase
GPY04_RS05805	COG2731	YhcH YjgK YiaL family protein
GPY04_RS05810	COG0251	oxidation-reduction process
GPY04_RS05815	COG1609	Transcriptional regulator
GPY04_RS05820	COG2723	6-phospho-beta-galactosidase activity
GPY04_RS05825	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY04_RS05830	COG0583	DNA-binding transcription factor activity
GPY04_RS05850	COG0577	efflux transmembrane transporter activity
GPY04_RS05850	COG1136	(ABC) transporter
GPY04_RS05855	COG0577	efflux transmembrane transporter activity
GPY04_RS05855	COG1136	(ABC) transporter
GPY04_RS05860	COG1136	(ABC) transporter
GPY04_RS05860	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY04_RS05865	COG1294	oxidase, subunit
GPY04_RS05870	COG1271	oxidase subunit
GPY04_RS05910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY04_RS05920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPY04_RS05940	COG0753	catalase activity
GPY04_RS05955	COG3527	Alpha-acetolactate decarboxylase
GPY04_RS05970	COG2200	EAL domain
GPY04_RS05970	COG2199	diguanylate cyclase activity
GPY04_RS05975	COG3706	GGDEF domain
GPY04_RS05980	COG2017	converts alpha-aldose to the beta-anomer
GPY04_RS05985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY04_RS05990	COG1085	galactose-1-phosphate uridylyltransferase
GPY04_RS06015	COG3706	GGDEF domain
GPY04_RS06015	COG0745	RESPONSE REGULATOR receiver
GPY04_RS06035	COG0835	chemotaxis
GPY04_RS06035	COG0784	Response regulator, receiver
GPY04_RS06045	COG4565	transcriptional regulatory protein
GPY04_RS06050	COG3290	protein histidine kinase activity
GPY04_RS06065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY04_RS06085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY04_RS06090	COG3063	Type IV pilus biogenesis stability protein PilW
GPY04_RS06105	COG1451	nucleotide metabolic process
GPY04_RS06115	COG0583	DNA-binding transcription factor activity
GPY04_RS06135	COG1538	Outer membrane efflux protein
GPY04_RS06145	COG0019	diaminopimelate decarboxylase activity
GPY04_RS06150	COG1748	Saccharopine dehydrogenase
GPY04_RS06160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY04_RS06175	COG4181	ATPase activity
GPY04_RS06180	COG0534	Mate efflux family protein
GPY04_RS06185	COG0702	epimerase
GPY04_RS06195	COG2814	Major facilitator Superfamily
GPY04_RS06200	COG1187	pseudouridine synthase activity
GPY04_RS06205	COG1061	Type III restriction enzyme res subunit
GPY04_RS06225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY04_RS06230	COG5001	Diguanylate cyclase
GPY04_RS06230	COG4251	negative regulation of phosphorylation
GPY04_RS06230	COG3706	GGDEF domain
GPY04_RS06230	COG2203	Gaf domain
GPY04_RS06240	COG0840	transmembrane signaling receptor activity
GPY04_RS06270	COG4934	collagen metabolic process
GPY04_RS06290	COG2239	Acts as a magnesium transporter
GPY04_RS06300	COG0814	amino acid
GPY04_RS06305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY04_RS06310	COG1131	(ABC) transporter
GPY04_RS06315	COG0842	Transport permease protein
GPY04_RS06325	COG3313	Fe-S protein
GPY04_RS06335	COG4134	Bacterial extracellular solute-binding protein
GPY04_RS06340	COG4135	transport system, permease component
GPY04_RS06345	COG4136	ATPase activity
GPY04_RS06350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY04_RS06355	COG0564	pseudouridine synthase activity
GPY04_RS06360	COG0733	neurotransmitter:sodium symporter activity
GPY04_RS06370	COG0626	cystathionine gamma-synthase activity
GPY04_RS06375	COG2818	Glycosylase
GPY04_RS06390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY04_RS06405	COG1842	Phage shock protein A
GPY04_RS06410	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY04_RS06420	COG4168	peptide transport system, permease
GPY04_RS06425	COG4171	peptide transport system, permease
GPY04_RS06435	COG4172	Belongs to the ABC transporter superfamily
GPY04_RS06450	COG1227	inorganic diphosphatase activity
GPY04_RS06470	COG0243	molybdopterin cofactor binding
GPY04_RS06475	COG3005	denitrification pathway
GPY04_RS06480	COG4459	periplasmic nitrate reductase
GPY04_RS06490	COG2116	formate transmembrane transporter activity
GPY04_RS06500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY04_RS06505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY04_RS06515	COG2917	probably involved in intracellular septation
GPY04_RS06520	COG1607	acyl-coa hydrolase
GPY04_RS06525	COG2350	Protein conserved in bacteria
GPY04_RS06535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY04_RS06540	COG0583	DNA-binding transcription factor activity
GPY04_RS06555	COG0612	Peptidase, M16
GPY04_RS06565	COG1032	radical SAM domain protein
GPY04_RS06580	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY04_RS06585	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY04_RS06590	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY04_RS06595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY04_RS06600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY04_RS06605	COG0745	RESPONSE REGULATOR receiver
GPY04_RS06610	COG3381	protein complex oligomerization
GPY04_RS06615	COG1609	Transcriptional regulator
GPY04_RS06620	COG3070	regulator of competence-specific genes
GPY04_RS06640	COG0297	glycogen (starch) synthase activity
GPY04_RS06645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY04_RS06650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY04_RS06660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY04_RS06670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY04_RS06675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY04_RS06680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY04_RS06685	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY04_RS06710	COG1012	belongs to the aldehyde dehydrogenase family
GPY04_RS06715	COG1309	transcriptional regulator
GPY04_RS06735	COG0668	transmembrane transport
GPY04_RS06740	COG2995	paraquat-inducible protein a
GPY04_RS06745	COG3008	intermembrane lipid transfer
GPY04_RS06745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY04_RS06755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY04_RS06770	COG0582	viral genome integration into host DNA
GPY04_RS06775	COG0582	viral genome integration into host DNA
GPY04_RS06780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY04_RS06800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY04_RS06820	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY04_RS06840	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY04_RS06845	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GPY04_RS06850	COG1737	Transcriptional regulator
GPY04_RS06855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY04_RS06860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY04_RS06865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY04_RS06870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY04_RS06880	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GPY04_RS06885	COG1940	carbohydrate kinase activity
GPY04_RS06890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY04_RS06895	COG4409	exo-alpha-(2->6)-sialidase activity
GPY04_RS06905	COG2003	Belongs to the UPF0758 family
GPY04_RS06920	COG3941	tape measure
GPY04_RS06960	COG0488	(ABC) transporter
GPY04_RS07040	COG0415	Belongs to the DNA photolyase family
GPY04_RS07050	COG4628	conserved protein (DUF2132)
GPY04_RS07055	COG3284	Transcriptional regulator
GPY04_RS07060	COG1012	belongs to the aldehyde dehydrogenase family
GPY04_RS07070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY04_RS07075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY04_RS07080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY04_RS07090	COG2207	Transcriptional regulator
GPY04_RS07095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY04_RS07095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY04_RS07095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY04_RS07100	COG1482	cell wall glycoprotein biosynthetic process
GPY04_RS07110	COG5002	protein histidine kinase activity
GPY04_RS07110	COG0784	Response regulator, receiver
GPY04_RS07120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY04_RS07130	COG2885	chlorophyll binding
GPY04_RS07135	COG0823	Involved in the tonB-independent uptake of proteins
GPY04_RS07150	COG0811	peptide transport
GPY04_RS07155	COG0824	Thioesterase
GPY04_RS07160	COG3790	cyd operon protein YbgE
GPY04_RS07165	COG4890	Cyd operon protein YbgT
GPY04_RS07170	COG1294	oxidase, subunit
GPY04_RS07175	COG1271	oxidase subunit
GPY04_RS07180	COG2255	four-way junction helicase activity
GPY04_RS07185	COG0632	four-way junction helicase activity
GPY04_RS07190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY04_RS07195	COG0215	cysteine-tRNA ligase activity
GPY04_RS07200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY04_RS07205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY04_RS07210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY04_RS07220	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY04_RS07225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY04_RS07230	COG1199	ATP-dependent helicase activity
GPY04_RS07235	COG0730	response to heat
GPY04_RS07240	COG3923	Primosomal replication protein n
GPY04_RS07250	COG0840	transmembrane signaling receptor activity
GPY04_RS07255	COG0708	Exodeoxyribonuclease III
GPY04_RS07260	COG4160	amino acid transport
GPY04_RS07265	COG4215	(ABC) transporter
GPY04_RS07285	COG1882	Formate acetyltransferase
GPY04_RS07295	COG0840	transmembrane signaling receptor activity
GPY04_RS07300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY04_RS07310	COG3013	Belongs to the UPF0304 family
GPY04_RS07315	COG2766	serine protein kinase
GPY04_RS07320	COG2718	Belongs to the UPF0229 family
GPY04_RS07325	COG2719	SpoVR family
GPY04_RS07330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY04_RS07340	COG1663	tetraacyldisaccharide 4'-kinase activity
GPY04_RS07345	COG1132	(ABC) transporter
GPY04_RS07350	COG0658	competence protein
GPY04_RS07350	COG2333	competence protein COMEC
GPY04_RS07365	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY04_RS07370	COG1136	(ABC) transporter
GPY04_RS07375	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY04_RS07385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY04_RS07405	COG1252	NADH dehydrogenase
GPY04_RS07435	COG0537	adenosine 5'-monophosphoramidase activity
GPY04_RS07450	COG2186	Transcriptional regulator
GPY04_RS07455	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY04_RS07460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY04_RS07465	COG1674	ftsk spoiiie
GPY04_RS07480	COG0686	Belongs to the AlaDH PNT family
GPY04_RS07490	COG0583	DNA-binding transcription factor activity
GPY04_RS07505	COG0284	orotidine-5'-phosphate decarboxylase activity
GPY04_RS07510	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY04_RS07515	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY04_RS07520	COG0776	regulation of translation
GPY04_RS07525	COG0539	negative regulation of cytoplasmic translation
GPY04_RS07530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY04_RS07535	COG1555	photosystem II stabilization
GPY04_RS07540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY04_RS07545	COG0776	regulation of translation
GPY04_RS07550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY04_RS07555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY04_RS07565	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY04_RS07575	COG4191	Histidine kinase
GPY04_RS07585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY04_RS07590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY04_RS07595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY04_RS07600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY04_RS07615	COG5001	Diguanylate cyclase
GPY04_RS07615	COG3300	MHYT domain
GPY04_RS07625	COG4589	Belongs to the CDS family
GPY04_RS07660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY04_RS07670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY04_RS07690	COG0243	molybdopterin cofactor binding
GPY04_RS07695	COG3005	denitrification pathway
GPY04_RS07700	COG3469	chitinase activity
GPY04_RS07700	COG3325	Belongs to the glycosyl hydrolase 18 family
GPY04_RS07705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY04_RS07715	COG2951	lytic endotransglycosylase activity
GPY04_RS07720	COG3100	YcgL domain-containing protein
GPY04_RS07725	COG0850	regulation of cytokinetic process
GPY04_RS07730	COG2894	cell division
GPY04_RS07735	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY04_RS07740	COG3015	lipoprotein NlpE involved in copper resistance
GPY04_RS07760	COG0477	Major facilitator Superfamily
GPY04_RS07765	COG0840	transmembrane signaling receptor activity
GPY04_RS07770	COG1396	sequence-specific DNA binding
GPY04_RS07775	COG3135	benzoate transporter
GPY04_RS07785	COG1441	menaquinone biosynthetic process
GPY04_RS07795	COG0596	Alpha beta hydrolase
GPY04_RS07800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY04_RS07805	COG1169	isochorismate synthase
GPY04_RS07810	COG0436	Aminotransferase
GPY04_RS07815	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY04_RS07820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY04_RS07840	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY04_RS07845	COG0318	PFAM AMP-dependent synthetase and ligase
GPY04_RS07850	COG0596	Alpha beta hydrolase
GPY04_RS07865	COG1214	PFAM Peptidase M22, glycoprotease
GPY04_RS07870	COG1199	ATP-dependent helicase activity
GPY04_RS07880	COG0788	formyltetrahydrofolate deformylase activity
GPY04_RS07885	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY04_RS07885	COG1902	pentaerythritol trinitrate reductase activity
GPY04_RS07890	COG0616	signal peptide processing
GPY04_RS07895	COG0252	asparaginase activity
GPY04_RS07900	COG3139	Protein of unknown function (DUF1315)
GPY04_RS07910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY04_RS07915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY04_RS07920	COG0676	glucose-6-phosphate 1-epimerase activity
GPY04_RS07930	COG2226	methyltransferase
GPY04_RS07945	COG0835	chemotaxis
GPY04_RS07945	COG0784	Response regulator, receiver
GPY04_RS07950	COG1940	carbohydrate kinase activity
GPY04_RS07960	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY04_RS07975	COG0733	neurotransmitter:sodium symporter activity
GPY04_RS07985	COG1263	PTS System
GPY04_RS07985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY04_RS07990	COG0084	hydrolase, TatD family'
GPY04_RS08000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY04_RS08005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY04_RS08010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY04_RS08015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY04_RS08020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY04_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
GPY04_RS08030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPY04_RS08035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY04_RS08040	COG0416	fatty acid biosynthetic process
GPY04_RS08045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPY04_RS08050	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY04_RS08055	COG0424	maF-like protein
GPY04_RS08060	COG0564	pseudouridine synthase activity
GPY04_RS08065	COG1530	ribonuclease E activity
GPY04_RS08070	COG0659	secondary active sulfate transmembrane transporter activity
GPY04_RS08080	COG1454	alcohol dehydrogenase
GPY04_RS08080	COG1012	belongs to the aldehyde dehydrogenase family
GPY04_RS08085	COG2095	MarC family integral membrane protein
GPY04_RS08090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY04_RS08095	COG1757	Na H antiporter
GPY04_RS08105	COG3081	Nucleoid-associated protein
GPY04_RS08115	COG3083	sulfuric ester hydrolase activity
GPY04_RS08130	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY04_RS08135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY04_RS08140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY04_RS08160	COG2853	Lipoprotein
GPY04_RS08170	COG3088	subunit of a heme lyase
GPY04_RS08170	COG4235	cytochrome complex assembly
GPY04_RS08175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY04_RS08180	COG1138	Cytochrome C-type biogenesis protein
GPY04_RS08185	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY04_RS08195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY04_RS08200	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY04_RS08205	COG4133	protoheme IX ABC transporter activity
GPY04_RS08215	COG0835	chemotaxis
GPY04_RS08225	COG1192	Involved in chromosome partitioning
GPY04_RS08230	COG2201	protein-glutamate methylesterase activity
GPY04_RS08235	COG0643	Histidine kinase
GPY04_RS08235	COG2198	Histidine kinase
GPY04_RS08240	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY04_RS08255	COG0455	bacterial-type flagellum organization
GPY04_RS08270	COG2062	phosphohistidine phosphatase, SixA
GPY04_RS08275	COG1025	Belongs to the peptidase M16 family
GPY04_RS08285	COG0018	arginyl-trna synthetase
GPY04_RS08305	COG1918	ferrous iron import across plasma membrane
GPY04_RS08310	COG4977	sequence-specific DNA binding
GPY04_RS08315	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY04_RS08320	COG1121	(ABC) transporter
GPY04_RS08325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY04_RS08335	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY04_RS08340	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY04_RS08345	COG0567	Dehydrogenase, E1 component
GPY04_RS08355	COG1053	succinate dehydrogenase
GPY04_RS08360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY04_RS08365	COG2009	succinate dehydrogenase
GPY04_RS08370	COG0372	Belongs to the citrate synthase family
GPY04_RS08375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY04_RS08385	COG0033	Phosphoglucomutase
GPY04_RS08390	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY04_RS08395	COG0596	Alpha beta hydrolase
GPY04_RS08410	COG1346	cytolysis
GPY04_RS08420	COG0583	DNA-binding transcription factor activity
GPY04_RS08430	COG0735	belongs to the Fur family
GPY04_RS08435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY04_RS08440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY04_RS08445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY04_RS08450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY04_RS08450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY04_RS08455	COG0431	NADPH-dependent FMN reductase
GPY04_RS08465	COG3101	peptidyl-lysine hydroxylation
GPY04_RS08470	COG2860	membrane
GPY04_RS08475	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY04_RS08480	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY04_RS08495	COG1684	flagellar biosynthetic protein fliR
GPY04_RS08500	COG1987	bacterial-type flagellum assembly
GPY04_RS08525	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY04_RS08550	COG1317	bacterial-type flagellum organization
GPY04_RS08555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY04_RS08565	COG1677	Flagellar hook-basal body complex protein FliE
GPY04_RS08570	COG2204	response regulator
GPY04_RS08575	COG4191	Histidine kinase
GPY04_RS08580	COG2204	response regulator
GPY04_RS08585	COG1516	flagellar protein fliS
GPY04_RS08595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY04_RS08600	COG1334	flagellar protein FlaG
GPY04_RS08605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY04_RS08610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY04_RS08615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY04_RS08620	COG2837	iron assimilation
GPY04_RS08640	COG1393	Belongs to the ArsC family
GPY04_RS08645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY04_RS08650	COG1876	peptidase activity
GPY04_RS08660	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY04_RS08665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY04_RS08675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY04_RS08695	COG4783	chaperone-mediated protein folding
GPY04_RS08700	COG1393	Belongs to the ArsC family
GPY04_RS08720	COG2233	PERMEase
GPY04_RS08725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY04_RS08730	COG0737	Belongs to the 5'-nucleotidase family
GPY04_RS08735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY04_RS08740	COG2912	Transglutaminase-like superfamily
GPY04_RS08745	COG3094	Invasion gene expression up-regulator, SirB
GPY04_RS08750	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY04_RS08755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY04_RS08760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY04_RS08765	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY04_RS08770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY04_RS08775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY04_RS08780	COG0193	aminoacyl-tRNA hydrolase activity
GPY04_RS08785	COG0012	GTP binding
GPY04_RS08870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY04_RS08875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY04_RS08895	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY04_RS08895	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY04_RS08900	COG1706	bacterial-type flagellum-dependent cell motility
GPY04_RS08905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY04_RS08910	COG4786	Flagellar basal body rod
GPY04_RS08915	COG4787	bacterial-type flagellum-dependent cell motility
GPY04_RS08920	COG1749	Flagellar hook protein flgE
GPY04_RS08925	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY04_RS08930	COG1558	bacterial-type flagellum-dependent cell motility
GPY04_RS08935	COG1815	bacterial-type flagellum-dependent cell motility
GPY04_RS08940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY04_RS08945	COG0835	chemotaxis
GPY04_RS08945	COG0784	Response regulator, receiver
GPY04_RS08980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY04_RS08980	COG2226	methyltransferase
GPY04_RS08980	COG3433	isochorismatase activity
GPY04_RS08985	COG2375	cellular response to nickel ion
GPY04_RS08990	COG1629	transport
GPY04_RS08990	COG4774	siderophore transport
GPY04_RS09005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY04_RS09010	COG2608	mercury ion transmembrane transporter activity
GPY04_RS09010	COG2217	Heavy metal translocating P-type atpase
GPY04_RS09025	COG3735	TraB family
GPY04_RS09040	COG2840	Smr protein MutS2
GPY04_RS09045	COG1187	pseudouridine synthase activity
GPY04_RS09050	COG3706	GGDEF domain
GPY04_RS09055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY04_RS09060	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY04_RS09065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY04_RS09070	COG0121	glutamine amidotransferase
GPY04_RS09075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY04_RS09080	COG1960	acyl-CoA dehydrogenase activity
GPY04_RS09090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY04_RS09095	COG0328	RNA-DNA hybrid ribonuclease activity
GPY04_RS09100	COG2226	methyltransferase
GPY04_RS09105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY04_RS09110	COG1388	LysM domain
GPY04_RS09110	COG0741	lytic transglycosylase activity
GPY04_RS09120	COG0347	Belongs to the P(II) protein family
GPY04_RS09125	COG3479	Phenolic acid decarboxylase
GPY04_RS09135	COG0037	tRNA processing
GPY04_RS09140	COG0825	malonyl-CoA metabolic process
GPY04_RS09145	COG0587	DNA-directed DNA polymerase activity
GPY04_RS09150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPY04_RS09155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY04_RS09160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY04_RS09165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY04_RS09170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY04_RS09175	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY04_RS09185	COG0750	zinc metalloprotease
GPY04_RS09190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY04_RS09195	COG0575	Belongs to the CDS family
GPY04_RS09200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY04_RS09205	COG0233	cytoplasmic translational termination
GPY04_RS09210	COG0528	UMP kinase activity
GPY04_RS09215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY04_RS09220	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY04_RS09225	COG0024	Methionine aminopeptidase
GPY04_RS09230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY04_RS09240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY04_RS09245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY04_RS09250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY04_RS09255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPY04_RS09270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY04_RS09270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY04_RS09275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY04_RS09280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY04_RS09285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY04_RS09300	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY04_RS09305	COG2252	PERMEase
GPY04_RS09310	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY04_RS09315	COG0189	ligase activity
GPY04_RS09315	COG4067	protein conserved in archaea
GPY04_RS09320	COG0189	ligase activity
GPY04_RS09330	COG0733	neurotransmitter:sodium symporter activity
GPY04_RS09335	COG3706	GGDEF domain
GPY04_RS09345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY04_RS09355	COG1477	protein flavinylation
GPY04_RS09360	COG2871	sodium ion transport
GPY04_RS09365	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY04_RS09370	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY04_RS09375	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY04_RS09380	COG1805	sodium ion transport
GPY04_RS09385	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY04_RS09390	COG0271	Belongs to the BolA IbaG family
GPY04_RS09395	COG2813	Specifically methylates the guanine in position
GPY04_RS09405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY04_RS09415	COG2211	Major facilitator Superfamily
GPY04_RS09425	COG1595	DNA-templated transcription, initiation
GPY04_RS09435	COG3248	Nucleoside-binding outer membrane protein
GPY04_RS09440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY04_RS09445	COG0693	protein deglycase activity
GPY04_RS09450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY04_RS09455	COG2166	iron-sulfur cluster assembly
GPY04_RS09460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY04_RS09465	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY04_RS09475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY04_RS09475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY04_RS09485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY04_RS09490	COG1074	ATP-dependent DNA helicase activity
GPY04_RS09495	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY04_RS09510	COG3141	response to X-ray
GPY04_RS09515	COG2171	N-acyltransferase activity
GPY04_RS09525	COG0456	acetyltransferase
GPY04_RS09530	COG0569	domain protein
GPY04_RS09530	COG0189	ligase activity
GPY04_RS09545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY04_RS09550	COG1609	Transcriptional regulator
GPY04_RS09555	COG3250	beta-galactosidase activity
GPY04_RS09570	COG1022	Amp-dependent synthetase and ligase
GPY04_RS09575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY04_RS09580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY04_RS09590	COG0560	Phosphoserine phosphatase
GPY04_RS09600	COG0813	purine-nucleoside phosphorylase activity
GPY04_RS09605	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY04_RS09610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY04_RS09615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY04_RS09625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY04_RS09630	COG0084	hydrolase, TatD family'
GPY04_RS09645	COG1115	amino acid carrier protein
GPY04_RS09660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY04_RS09665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY04_RS09670	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY04_RS09675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY04_RS09680	COG0083	homoserine kinase activity
GPY04_RS09700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY04_RS09710	COG0745	RESPONSE REGULATOR receiver
GPY04_RS09715	COG0784	Response regulator, receiver
GPY04_RS09715	COG2198	Histidine kinase
GPY04_RS09715	COG5002	protein histidine kinase activity
GPY04_RS09720	COG5001	Diguanylate cyclase
GPY04_RS09720	COG2203	Gaf domain
GPY04_RS09720	COG3706	GGDEF domain
GPY04_RS09720	COG4251	negative regulation of phosphorylation
GPY04_RS09725	COG1242	4 iron, 4 sulfur cluster binding
GPY04_RS09730	COG0067	glutamate synthase
GPY04_RS09730	COG0069	glutamate synthase activity
GPY04_RS09730	COG0070	glutamate synthase
GPY04_RS09740	COG0067	glutamate synthase
GPY04_RS09740	COG0069	glutamate synthase activity
GPY04_RS09740	COG0070	glutamate synthase
GPY04_RS09745	COG0493	'glutamate synthase
GPY04_RS09755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY04_RS09765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY04_RS09770	COG2860	membrane
GPY04_RS09775	COG0583	DNA-binding transcription factor activity
GPY04_RS09780	COG0730	response to heat
GPY04_RS09790	COG4172	Belongs to the ABC transporter superfamily
GPY04_RS09805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY04_RS09810	COG0505	Belongs to the CarA family
GPY04_RS09820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPY04_RS09825	COG0494	nUDIX hydrolase
GPY04_RS09830	COG0653	protein targeting
GPY04_RS09840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY04_RS09845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY04_RS09850	COG0849	cell division
GPY04_RS09855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY04_RS09860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY04_RS09865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY04_RS09870	COG0772	Belongs to the SEDS family
GPY04_RS09875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY04_RS09880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY04_RS09885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY04_RS09890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY04_RS09895	COG0768	penicillin binding
GPY04_RS09900	COG3116	cell division
GPY04_RS09905	COG0275	rRNA processing
GPY04_RS09915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY04_RS09920	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY04_RS09925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY04_RS09930	COG2186	Transcriptional regulator
GPY04_RS09935	COG0737	Belongs to the 5'-nucleotidase family
GPY04_RS09940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY04_RS09945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY04_RS09950	COG4974	Belongs to the 'phage' integrase family
GPY04_RS09955	COG0716	FMN binding
GPY04_RS09975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY04_RS09980	COG1459	type II secretion system
GPY04_RS09990	COG0237	dephospho-CoA kinase activity
GPY04_RS09995	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY04_RS10000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY04_RS10005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY04_RS10010	COG0187	DNA topoisomerase II activity
GPY04_RS10015	COG3150	esterase
GPY04_RS10025	COG3151	Protein conserved in bacteria
GPY04_RS10030	COG0494	nUDIX hydrolase
GPY04_RS10035	COG1538	Outer membrane efflux protein
GPY04_RS10045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY04_RS10050	COG0840	transmembrane signaling receptor activity
GPY04_RS10055	COG3025	triphosphatase activity
GPY04_RS10060	COG1392	Phosphate transport regulator
GPY04_RS10065	COG0306	phosphate transporter
GPY04_RS10070	COG4991	sh3 domain protein
GPY04_RS10080	COG3267	Type II secretory pathway component ExeA
GPY04_RS10080	COG3409	Peptidoglycan-binding domain 1 protein
GPY04_RS10085	COG0617	tRNA 3'-terminal CCA addition
GPY04_RS10090	COG0148	phosphopyruvate hydratase activity
GPY04_RS10095	COG0504	CTP synthase activity
GPY04_RS10100	COG3956	TIGRFAM MazG family protein
GPY04_RS10105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY04_RS10110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY04_RS10120	COG5001	Diguanylate cyclase
GPY04_RS10135	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY04_RS10140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY04_RS10145	COG1381	Involved in DNA repair and RecF pathway recombination
GPY04_RS10150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY04_RS10155	COG0571	ribonuclease III activity
GPY04_RS10160	COG0681	Belongs to the peptidase S26 family
GPY04_RS10165	COG0481	GTPase activity
GPY04_RS10170	COG3086	response to oxidative stress
GPY04_RS10175	COG3026	antisigma factor binding
GPY04_RS10185	COG1595	DNA-templated transcription, initiation
GPY04_RS10190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY04_RS10200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY04_RS10205	COG0354	folic acid binding
GPY04_RS10215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY04_RS10220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY04_RS10230	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY04_RS10240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY04_RS10245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY04_RS10250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY04_RS10255	COG0440	acetolactate synthase activity
GPY04_RS10260	COG0028	Belongs to the TPP enzyme family
GPY04_RS10265	COG1022	Amp-dependent synthetase and ligase
GPY04_RS10270	COG0583	DNA-binding transcription factor activity
GPY04_RS10290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY04_RS10295	COG0473	3-isopropylmalate dehydrogenase activity
GPY04_RS10300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY04_RS10305	COG0066	3-isopropylmalate dehydratase activity
GPY04_RS10350	COG3437	response regulator, receiver
GPY04_RS10365	COG0795	lipopolysaccharide-transporting ATPase activity
GPY04_RS10370	COG0795	lipopolysaccharide-transporting ATPase activity
GPY04_RS10375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY04_RS10380	COG2927	DNA polymerase III (CHI subunit)
GPY04_RS10385	COG0525	valine-tRNA ligase activity
GPY04_RS10390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY04_RS10395	COG0564	pseudouridine synthase activity
GPY04_RS10400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY04_RS10405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY04_RS10410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY04_RS10415	COG0540	Belongs to the ATCase OTCase family
GPY04_RS10420	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY04_RS10425	COG0251	oxidation-reduction process
GPY04_RS10430	COG0204	Acyl-transferase
GPY04_RS10435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY04_RS10440	COG5007	Belongs to the BolA IbaG family
GPY04_RS10450	COG2854	intermembrane phospholipid transfer
GPY04_RS10455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY04_RS10460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY04_RS10465	COG1127	ABC transporter
GPY04_RS10475	COG0517	IMP dehydrogenase activity
GPY04_RS10475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY04_RS10490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY04_RS10495	COG1137	ATPase activity
GPY04_RS10505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY04_RS10510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY04_RS10515	COG1660	Displays ATPase and GTPase activities
GPY04_RS10520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY04_RS10525	COG2239	Acts as a magnesium transporter
GPY04_RS10530	COG0312	modulator of DNA gyrase
GPY04_RS10535	COG3028	Belongs to the UPF0307 family
GPY04_RS10540	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY04_RS10545	COG1178	ABC-type Fe3 transport system permease component
GPY04_RS10550	COG4143	(ABC) transporter
GPY04_RS10555	COG0163	prenyltransferase activity
GPY04_RS10560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY04_RS10565	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY04_RS10570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY04_RS10575	COG2105	PFAM AIG2 family protein
GPY04_RS10585	COG0729	surface antigen
GPY04_RS10590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY04_RS10595	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY04_RS10610	COG1136	(ABC) transporter
GPY04_RS10630	COG0529	Catalyzes the synthesis of activated sulfate
GPY04_RS10635	COG2895	sulfate adenylyltransferase (ATP) activity
GPY04_RS10640	COG0175	sulfate reduction
GPY04_RS10645	COG1648	precorrin-2 dehydrogenase activity
GPY04_RS10645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY04_RS10650	COG0737	Belongs to the 5'-nucleotidase family
GPY04_RS10660	COG0513	Belongs to the DEAD box helicase family
GPY04_RS10665	COG2153	protein acetylation
GPY04_RS10670	COG0697	spore germination
GPY04_RS10675	COG3266	domain, Protein
GPY04_RS10675	COG3061	Opacity-associated protein A
GPY04_RS10680	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY04_RS10690	COG0203	ribosomal protein L17
GPY04_RS10695	COG0202	RNA polymerase activity
GPY04_RS10700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY04_RS10705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY04_RS10710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY04_RS10720	COG0201	protein transport
GPY04_RS10725	COG0200	Binds to the 23S rRNA
GPY04_RS10730	COG1841	ribosomal large subunit assembly
GPY04_RS10735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPY04_RS10740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY04_RS10745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY04_RS10750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY04_RS10755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY04_RS10760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY04_RS10765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY04_RS10770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY04_RS10775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY04_RS10780	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY04_RS10785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPY04_RS10790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY04_RS10795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY04_RS10800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY04_RS10805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY04_RS10810	COG0089	rRNA binding
GPY04_RS10815	COG0088	Forms part of the polypeptide exit tunnel
GPY04_RS10820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY04_RS10825	COG0051	transcription antitermination factor activity, RNA binding
GPY04_RS10830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY04_RS10835	COG0557	exoribonuclease II activity
GPY04_RS10840	COG3083	sulfuric ester hydrolase activity
GPY04_RS10845	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY04_RS10850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY04_RS10860	COG1047	Peptidyl-prolyl cis-trans
GPY04_RS10875	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY04_RS10880	COG0488	(ABC) transporter
GPY04_RS10890	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY04_RS10900	COG3954	Phosphoribulokinase
GPY04_RS10905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY04_RS10915	COG1012	belongs to the aldehyde dehydrogenase family
GPY04_RS10925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY04_RS10935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY04_RS10950	COG0180	Tryptophanyl-tRNA synthetase
GPY04_RS10955	COG0546	phosphoglycolate phosphatase activity
GPY04_RS10960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY04_RS10965	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY04_RS10975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY04_RS10980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY04_RS11010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY04_RS11020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY04_RS11020	COG0678	peroxiredoxin activity
GPY04_RS11025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY04_RS11035	COG0165	Argininosuccinate lyase
GPY04_RS11040	COG0137	argininosuccinate synthase activity
GPY04_RS11045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY04_RS11050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY04_RS11055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY04_RS11060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY04_RS11070	COG1045	serine acetyltransferase
GPY04_RS11075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY04_RS11080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY04_RS11085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY04_RS11090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY04_RS11095	COG1053	succinate dehydrogenase
GPY04_RS11100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY04_RS11105	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY04_RS11110	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY04_RS11115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY04_RS11120	COG1509	lysine 2,3-aminomutase activity
GPY04_RS11130	COG0459	protein refolding
GPY04_RS11135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY04_RS11160	COG0149	triose-phosphate isomerase activity
GPY04_RS11170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY04_RS11175	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY04_RS11180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY04_RS11185	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY04_RS11190	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY04_RS11195	COG1609	Transcriptional regulator
GPY04_RS11200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY04_RS11205	COG0254	rRNA binding
GPY04_RS11210	COG0281	malic enzyme
GPY04_RS11215	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPY04_RS11220	COG0626	cystathionine gamma-synthase activity
GPY04_RS11225	COG0460	homoserine dehydrogenase
GPY04_RS11225	COG0527	aspartate kinase activity
GPY04_RS11230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY04_RS11235	COG3074	FtsZ-dependent cytokinesis
GPY04_RS11240	COG1494	fructose-1,6-bisphosphatase
GPY04_RS11245	COG0205	6-phosphofructokinase activity
GPY04_RS11250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY04_RS11260	COG0745	RESPONSE REGULATOR receiver
GPY04_RS11265	COG2205	protein histidine kinase activity
GPY04_RS11275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY04_RS11280	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY04_RS11285	COG3706	GGDEF domain
GPY04_RS11290	COG1027	Aspartate ammonia-lyase
GPY04_RS11295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY04_RS11305	COG4232	protein-disulfide reductase activity
GPY04_RS11315	COG3263	regulation of cellular component size
GPY04_RS11325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY04_RS11330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY04_RS11335	COG0194	GDP metabolic process
GPY04_RS11340	COG1758	RNA polymerase activity
GPY04_RS11345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY04_RS11350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY04_RS11355	COG2233	PERMEase
GPY04_RS11365	COG0745	RESPONSE REGULATOR receiver
GPY04_RS11370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY04_RS11375	COG2183	response to ionizing radiation
GPY04_RS11385	COG0596	Alpha beta hydrolase
GPY04_RS11390	COG1040	competence protein
GPY04_RS11395	COG0316	Belongs to the HesB IscA family
GPY04_RS11395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY04_RS11400	COG0494	nUDIX hydrolase
GPY04_RS11405	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY04_RS11415	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY04_RS11420	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY04_RS11425	COG3156	type II secretion system protein K
GPY04_RS11430	COG4795	General secretion pathway protein
GPY04_RS11435	COG2165	general secretion pathway protein
GPY04_RS11440	COG2165	general secretion pathway protein
GPY04_RS11445	COG2165	general secretion pathway protein
GPY04_RS11450	COG1459	type II secretion system
GPY04_RS11455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY04_RS11465	COG3031	protein transport across the cell outer membrane
GPY04_RS11470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY04_RS11475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY04_RS11480	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY04_RS11490	COG0456	acetyltransferase
GPY04_RS11495	COG1490	D-aminoacyl-tRNA deacylase activity
GPY04_RS11505	COG1660	Displays ATPase and GTPase activities
GPY04_RS11520	COG0174	glutamine synthetase
GPY04_RS11530	COG3852	Histidine kinase
GPY04_RS11540	COG3300	MHYT domain
GPY04_RS11540	COG5001	Diguanylate cyclase
GPY04_RS11545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY04_RS11615	COG0175	sulfate reduction
GPY04_RS11620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY04_RS11625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY04_RS11650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY04_RS11655	COG0735	belongs to the Fur family
GPY04_RS11670	COG0166	Belongs to the GPI family
GPY04_RS11675	COG0432	Pfam Uncharacterised protein family UPF0047
GPY04_RS11680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY04_RS11685	COG0305	Participates in initiation and elongation during chromosome replication
GPY04_RS11695	COG0359	binds to the 23S rRNA
GPY04_RS11700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPY04_RS11705	COG2965	DNA replication, synthesis of RNA primer
GPY04_RS11710	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY04_RS11720	COG2906	2 iron, 2 sulfur cluster binding
GPY04_RS11725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY04_RS11730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY04_RS11735	COG0049	tRNA binding
GPY04_RS11740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPY04_RS11750	COG2923	Belongs to the DsrF TusC family
GPY04_RS11755	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY04_RS11760	COG2964	Protein conserved in bacteria
GPY04_RS11765	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY04_RS11775	COG2900	Belongs to the SlyX family
GPY04_RS11780	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY04_RS11785	COG0330	HflC and HflK could
GPY04_RS11790	COG0330	HflC and HflK could
GPY04_RS11795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY04_RS11800	COG1923	regulation of RNA biosynthetic process
GPY04_RS11805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY04_RS11810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY04_RS11820	COG0802	atpase or kinase
GPY04_RS11825	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY04_RS11880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY04_RS11885	COG1162	GTPase activity
GPY04_RS11890	COG0688	phosphatidylethanolamine metabolic process
GPY04_RS11895	COG0471	metal ion transport
GPY04_RS11895	COG0490	domain, Protein
GPY04_RS11905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY04_RS11910	COG4942	peptidase
GPY04_RS11925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY04_RS11930	COG2816	NAD+ diphosphatase activity
GPY04_RS11935	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY04_RS11940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY04_RS11945	COG0085	RNA polymerase activity
GPY04_RS11950	COG0222	ribosome binding
GPY04_RS11955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY04_RS11960	COG0081	regulation of translation
GPY04_RS11965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY04_RS11970	COG0250	Participates in transcription elongation, termination and antitermination
GPY04_RS11975	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY04_RS11980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY04_RS12005	COG1072	(Pantothenic acid kinase))
GPY04_RS12015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY04_RS12025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY04_RS12070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY04_RS12080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY04_RS12085	COG3118	belongs to the thioredoxin family
GPY04_RS12090	COG0513	Belongs to the DEAD box helicase family
GPY04_RS12095	COG0248	Ppx GppA phosphatase
GPY04_RS12100	COG0784	Response regulator, receiver
GPY04_RS12100	COG2205	protein histidine kinase activity
GPY04_RS12105	COG2814	Major facilitator Superfamily
GPY04_RS12125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY04_RS12130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY04_RS12135	COG0511	ligase activity, forming carbon-carbon bonds
GPY04_RS12140	COG0439	Biotin carboxylase
GPY04_RS12145	COG2264	protein methyltransferase activity
GPY04_RS12150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY04_RS12155	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY04_RS12160	COG1609	Transcriptional regulator
GPY04_RS12165	COG0129	dihydroxy-acid dehydratase activity
GPY04_RS12170	COG3265	gluconokinase activity
GPY04_RS12180	COG0800	Aldolase
GPY04_RS12200	COG0840	transmembrane signaling receptor activity
GPY04_RS12205	COG1982	Orn Lys Arg decarboxylase major
GPY04_RS12210	COG0531	amino acid
GPY04_RS12215	COG3710	Transcriptional regulator
GPY04_RS12220	COG0789	Transcriptional regulator
GPY04_RS12230	COG0138	bifunctional purine biosynthesis protein purh
GPY04_RS12235	COG0151	Belongs to the GarS family
GPY04_RS12245	COG0776	regulation of translation
GPY04_RS12250	COG1253	flavin adenine dinucleotide binding
GPY04_RS12255	COG1940	carbohydrate kinase activity
GPY04_RS12265	COG3068	Protein conserved in bacteria
GPY04_RS12275	COG1573	uracil-dna glycosylase
GPY04_RS12280	COG0668	transmembrane transport
GPY04_RS12285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY04_RS12290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY04_RS12335	COG1012	belongs to the aldehyde dehydrogenase family
GPY04_RS12335	COG1454	alcohol dehydrogenase
GPY04_RS12340	COG0318	PFAM AMP-dependent synthetase and ligase
GPY04_RS12370	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GPY04_RS12375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY04_RS12380	COG0662	Cupin 2, conserved barrel domain protein
GPY04_RS12380	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GPY04_RS12385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY04_RS12420	COG1519	Transferase
GPY04_RS12450	COG3642	lipopolysaccharide core region biosynthetic process
GPY04_RS12455	COG0859	PFAM glycosyl transferase family 9
GPY04_RS12460	COG0463	Glycosyl transferase, family 2
GPY04_RS12465	COG0859	PFAM glycosyl transferase family 9
GPY04_RS12470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY04_RS12475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY04_RS12485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY04_RS12490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPY04_RS12505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY04_RS12515	COG1309	transcriptional regulator
GPY04_RS12520	COG1560	Kdo2-lipid A biosynthetic process
GPY04_RS12525	COG1560	Kdo2-lipid A biosynthetic process
GPY04_RS12530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY04_RS12535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY04_RS12540	COG1561	YicC-like family, N-terminal region
GPY04_RS12550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY04_RS12550	COG1263	PTS System
GPY04_RS12555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY04_RS12580	COG1120	ATPase activity
GPY04_RS12585	COG4774	siderophore transport
GPY04_RS12590	COG1132	(ABC) transporter
GPY04_RS12605	COG0514	ATP-dependent DNA helicase (RecQ)
GPY04_RS12610	COG2962	Rard protein
GPY04_RS12625	COG1280	lysine exporter protein (LysE YggA)
GPY04_RS12630	COG0210	DNA helicase
GPY04_RS12640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY04_RS12645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY04_RS12720	COG2131	deaminase
GPY04_RS12730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY04_RS12740	COG0747	negative chemotaxis
GPY04_RS12795	COG1309	transcriptional regulator
GPY04_RS12800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY04_RS12805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY04_RS12810	COG2960	long-chain fatty acid transporting porin activity
GPY04_RS12815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY04_RS12820	COG0583	DNA-binding transcription factor activity
GPY04_RS12865	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPY04_RS12870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY04_RS12875	COG1739	Uncharacterized protein family UPF0029
GPY04_RS12880	COG1024	Enoyl-CoA hydratase
GPY04_RS12880	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY04_RS12885	COG0183	Belongs to the thiolase family
GPY04_RS12890	COG0583	DNA-binding transcription factor activity
GPY04_RS12895	COG2814	Major facilitator Superfamily
GPY04_RS12900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY04_RS12905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY04_RS12910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY04_RS12915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY04_RS12920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY04_RS12925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY04_RS12930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY04_RS12940	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY04_RS12945	COG3312	ion transport
GPY04_RS12950	COG1475	DNA binding
GPY04_RS12955	COG1192	Involved in chromosome partitioning
GPY04_RS12960	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY04_RS12965	COG0445	tRNA wobble uridine modification
GPY04_RS12975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY04_RS12980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY04_RS12985	COG0706	membrane insertase activity
GPY04_RS12990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY04_RS12995	COG0594	ribonuclease P activity
GPY04_RS13000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY04_RS13005	COG1126	abc transporter atp-binding protein
GPY04_RS13020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY04_RS13025	COG0592	DNA-directed DNA polymerase activity
GPY04_RS13030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY04_RS13035	COG0187	DNA topoisomerase II activity
GPY04_RS13050	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY04_RS13055	COG3977	Valine--pyruvate aminotransferase
GPY04_RS13060	COG0751	glycine-tRNA ligase activity
GPY04_RS13065	COG0752	glycyl-tRNA synthetase alpha subunit
GPY04_RS13070	COG2119	membrane
GPY04_RS13080	COG0425	Belongs to the sulfur carrier protein TusA family
GPY04_RS13090	COG0604	alcohol dehydrogenase
GPY04_RS13100	COG0129	dihydroxy-acid dehydratase activity
GPY04_RS13105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY04_RS13120	COG0606	chelatase, subunit chli
GPY04_RS13125	COG0204	Acyl-transferase
GPY04_RS13130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY04_RS13135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY04_RS13145	COG3084	Protein conserved in bacteria
GPY04_RS13155	COG4326	sporulation control protein
GPY04_RS13160	COG1272	protein, Hemolysin III
GPY04_RS13170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY04_RS13175	COG0569	domain protein
GPY04_RS13180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY04_RS13180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY04_RS13185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY04_RS13190	COG0242	peptide deformylase activity
GPY04_RS13195	COG1652	LysM domain
GPY04_RS13200	COG0758	DNA mediated transformation
GPY04_RS13205	COG2922	Belongs to the Smg family
GPY04_RS13210	COG0551	DNA topoisomerase type I activity
GPY04_RS13215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY04_RS13220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY04_RS13225	COG0009	L-threonylcarbamoyladenylate synthase
GPY04_RS13230	COG0408	coproporphyrinogen oxidase activity
GPY04_RS13235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY04_RS13245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY04_RS13285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY04_RS13290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY04_RS13300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY04_RS13305	COG2104	thiamine diphosphate biosynthetic process
GPY04_RS13310	COG2022	thiamine diphosphate biosynthetic process
GPY04_RS13315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY04_RS13320	COG0006	proline dipeptidase activity
GPY04_RS13320	COG0006	proline dipeptidase activity
GPY04_RS13340	COG1522	sequence-specific DNA binding
GPY04_RS13345	COG5002	protein histidine kinase activity
GPY04_RS13345	COG5001	Diguanylate cyclase
GPY04_RS13350	COG0742	ribosomal rna small subunit methyltransferase
GPY04_RS13360	COG0697	spore germination
GPY04_RS13365	COG0589	response to stress
GPY04_RS13375	COG1528	Iron-storage protein
GPY04_RS13385	COG2081	HI0933 family
GPY04_RS13395	COG1322	Protein conserved in bacteria
GPY04_RS13400	COG2226	methyltransferase
GPY04_RS13410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY04_RS13415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY04_RS13420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY04_RS13425	COG0805	protein transport
GPY04_RS13430	COG1858	cytochrome C peroxidase
GPY04_RS13435	COG0534	Mate efflux family protein
GPY04_RS13445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY04_RS13450	COG2937	Belongs to the GPAT DAPAT family
GPY04_RS13455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY04_RS13460	COG3161	chorismate lyase activity
GPY04_RS13470	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY04_RS13475	COG0840	transmembrane signaling receptor activity
GPY04_RS13485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY04_RS13490	COG0084	hydrolase, TatD family'
GPY04_RS13505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY04_RS13505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY04_RS13510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY04_RS13525	COG3078	GTPase activator activity
GPY04_RS13535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY04_RS13540	COG3071	HemY protein
GPY04_RS13545	COG2959	enzyme of heme biosynthesis
GPY04_RS13550	COG1587	Uroporphyrinogen-III synthase
GPY04_RS13555	COG0181	hydroxymethylbilane synthase activity
GPY04_RS13565	COG3072	Adenylate cyclase
GPY04_RS13570	COG1965	Belongs to the frataxin family
GPY04_RS13580	COG0019	diaminopimelate decarboxylase activity
GPY04_RS13585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY04_RS13595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY04_RS13600	COG1011	Hydrolase
GPY04_RS13605	COG2200	EAL domain
GPY04_RS13605	COG3287	FIST C domain
GPY04_RS13605	COG2199	diguanylate cyclase activity
GPY04_RS13620	COG0561	phosphatase activity
GPY04_RS13625	COG2267	carboxylic ester hydrolase activity
GPY04_RS13630	COG1280	lysine exporter protein (LysE YggA)
GPY04_RS13635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY04_RS13640	COG0783	Belongs to the Dps family
GPY04_RS13670	COG0742	ribosomal rna small subunit methyltransferase
GPY04_RS13675	COG0552	protein localization to endoplasmic reticulum
GPY04_RS13680	COG2884	Cell division ATP-binding protein ftsE
GPY04_RS13685	COG2177	Part of the ABC transporter FtsEX involved in
GPY04_RS13690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY04_RS13695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY04_RS13710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY04_RS13715	COG4206	TonB-dependent receptor
GPY04_RS13720	COG1404	Belongs to the peptidase S8 family
GPY04_RS13725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY04_RS13795	COG0646	methionine synthase
GPY04_RS13795	COG1410	methionine synthase
GPY04_RS13800	COG0527	aspartate kinase activity
GPY04_RS13805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY04_RS13815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY04_RS13830	COG0629	single-stranded DNA binding
GPY04_RS13835	COG2200	EAL domain
GPY04_RS13835	COG2199	diguanylate cyclase activity
GPY04_RS13860	COG3267	Type II secretory pathway component ExeA
GPY04_RS13860	COG3409	Peptidoglycan-binding domain 1 protein
GPY04_RS13870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY04_RS13875	COG1459	type II secretion system
GPY04_RS13920	COG1077	Cell shape determining protein MreB Mrl
GPY04_RS13925	COG1792	Involved in formation and maintenance of cell shape
GPY04_RS13930	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY04_RS13935	COG0424	maF-like protein
GPY04_RS13940	COG1530	ribonuclease E activity
GPY04_RS14005	COG1943	Transposase
GPY04_RS14100	COG0346	lactoylglutathione lyase activity
GPY04_RS14120	COG0110	maltose O-acetyltransferase activity
GPY04_RS14125	COG3039	Transposase
GPY04_RS14140	COG2944	sequence-specific DNA binding
GPY04_RS14145	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GPY04_RS14235	COG4977	sequence-specific DNA binding
GPY04_RS14300	COG3040	lipid binding
GPY04_RS14325	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPY04_RS14445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY04_RS14500	COG3040	lipid binding
GPY04_RS14530	COG0346	lactoylglutathione lyase activity
GPY04_RS14560	COG0384	phenazine biosynthesis protein PhzF
GPY04_RS14580	COG3093	addiction module antidote protein HigA
GPY04_RS14585	COG3549	Plasmid maintenance system killer
GPY04_RS14790	COG1280	lysine exporter protein (LysE YggA)
GPY04_RS14800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPY04_RS14815	COG3040	lipid binding
GPY04_RS14835	COG0346	lactoylglutathione lyase activity
GPY04_RS14885	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPY04_RS14970	COG3041	Addiction module toxin RelE StbE family
GPY04_RS15005	COG3040	lipid binding
GPY04_RS15010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY04_RS15030	COG0494	nUDIX hydrolase
GPY04_RS15060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY04_RS15095	COG1028	Short-chain dehydrogenase reductase Sdr
GPY04_RS15155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPY04_RS15160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY04_RS15170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY04_RS15195	COG3039	Transposase
GPY04_RS15205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY04_RS15215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY04_RS15220	COG0509	glycine decarboxylation via glycine cleavage system
GPY04_RS15225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY04_RS15225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY04_RS15235	COG1943	Transposase
GPY04_RS15255	COG1686	Belongs to the peptidase S11 family
GPY04_RS15270	COG2814	Major facilitator Superfamily
GPY04_RS15285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY04_RS15310	COG5002	protein histidine kinase activity
GPY04_RS15315	COG0745	RESPONSE REGULATOR receiver
GPY04_RS15340	COG0366	Alpha amylase catalytic
GPY04_RS15345	COG3038	cytochrome b561
GPY04_RS15375	COG0561	phosphatase activity
GPY04_RS15380	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPY04_RS15385	COG3623	hexulose-6-phosphate isomerase
GPY04_RS15395	COG0745	RESPONSE REGULATOR receiver
GPY04_RS15415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY04_RS15435	COG4604	ABC transporter, ATP-binding protein
GPY04_RS15440	COG4605	iron ion homeostasis
GPY04_RS15445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY04_RS15465	COG4412	M6 family metalloprotease domain protein
GPY04_RS15465	COG3291	Pkd domain containing protein
GPY04_RS15470	COG5380	lipid catabolic process
GPY04_RS15475	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY04_RS15480	COG0840	transmembrane signaling receptor activity
GPY04_RS15490	COG3240	lipase activity
GPY04_RS15495	COG3706	GGDEF domain
GPY04_RS15505	COG2814	Major facilitator Superfamily
GPY04_RS15510	COG1757	Na H antiporter
GPY04_RS15520	COG4191	Histidine kinase
GPY04_RS15520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY04_RS15525	COG3437	response regulator, receiver
GPY04_RS15525	COG0784	Response regulator, receiver
GPY04_RS15535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY04_RS15540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY04_RS15545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY04_RS15550	COG0513	Belongs to the DEAD box helicase family
GPY04_RS15565	COG1943	Transposase
GPY04_RS15590	COG0516	GMP reductase activity
GPY04_RS15600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY04_RS15610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY04_RS15615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY04_RS15615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY04_RS15640	COG3036	rescue of stalled ribosome
GPY04_RS15645	COG1278	Cold shock
GPY04_RS15650	COG1017	nitric oxide dioxygenase activity
GPY04_RS15650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY04_RS15655	COG3604	Transcriptional regulator
GPY04_RS15665	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY04_RS15670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY04_RS15685	COG0840	transmembrane signaling receptor activity
GPY04_RS15690	COG0714	Associated with various cellular activities
GPY04_RS15710	COG2304	oxidoreductase activity
GPY04_RS15725	COG1278	Cold shock
GPY04_RS15730	COG5001	Diguanylate cyclase
GPY04_RS15730	COG5002	protein histidine kinase activity
GPY04_RS15740	COG3530	Putative quorum-sensing-regulated virulence factor
GPY04_RS15750	COG3033	Beta-eliminating lyase
GPY04_RS15755	COG0814	amino acid
GPY04_RS15760	COG0589	response to stress
GPY04_RS15770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPY04_RS15770	COG2111	Na H antiporter
GPY04_RS15790	COG2212	antiporter activity
GPY04_RS15795	COG1320	monovalent cation:proton antiporter activity
GPY04_RS15805	COG0242	peptide deformylase activity
GPY04_RS15815	COG0579	oxidoreductase
GPY04_RS15860	COG0584	glycerophosphoryl diester phosphodiesterase
GPY04_RS15870	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY04_RS15880	COG1609	Transcriptional regulator
GPY04_RS15885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY04_RS15890	COG1879	ABC-type sugar transport system periplasmic component
GPY04_RS15895	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY04_RS15900	COG1129	ABC transporter
GPY04_RS15905	COG1869	D-ribose catabolic process
GPY04_RS15920	COG3501	Rhs element vgr protein
GPY04_RS16015	COG0564	pseudouridine synthase activity
GPY04_RS16025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY04_RS16030	COG2771	luxR family
GPY04_RS16030	COG2200	EAL domain
GPY04_RS16040	COG0673	inositol 2-dehydrogenase activity
GPY04_RS16045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY04_RS16075	COG1342	Belongs to the UPF0251 family
GPY04_RS16085	COG1301	dicarboxylic acid transport
GPY04_RS16110	COG2814	Major facilitator Superfamily
GPY04_RS16115	COG0583	DNA-binding transcription factor activity
GPY04_RS16120	COG5001	Diguanylate cyclase
GPY04_RS16120	COG3300	MHYT domain
GPY04_RS16125	COG0739	heme binding
GPY04_RS16135	COG0659	secondary active sulfate transmembrane transporter activity
GPY04_RS16155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY04_RS16160	COG0581	inorganic phosphate transmembrane transporter activity
GPY04_RS16165	COG0573	inorganic phosphate transmembrane transporter activity
GPY04_RS16170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY04_RS16200	COG1770	oligopeptidase
GPY04_RS16205	COG0513	Belongs to the DEAD box helicase family
GPY04_RS16215	COG1376	ErfK ybiS ycfS ynhG family protein
GPY04_RS16215	COG1388	LysM domain
GPY04_RS16220	COG0415	Belongs to the DNA photolyase family
GPY04_RS16230	COG3272	Protein of unknown function (DUF1722)
GPY04_RS16235	COG0813	purine-nucleoside phosphorylase activity
GPY04_RS16250	COG3706	GGDEF domain
GPY04_RS16260	COG1566	PFAM secretion protein HlyD family protein
GPY04_RS16280	COG0786	glutamate:sodium symporter activity
GPY04_RS16295	COG1999	signal sequence binding
GPY04_RS16305	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY04_RS16310	COG0671	phosphoesterase, PA-phosphatase related
GPY04_RS16355	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY04_RS16360	COG0471	metal ion transport
GPY04_RS16395	COG3501	Rhs element vgr protein
GPY04_RS16405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY04_RS16410	COG1640	4-alpha-glucanotransferase
GPY04_RS16415	COG0058	SHG alpha-glucan phosphorylase activity
GPY04_RS16420	COG2909	trisaccharide binding
GPY04_RS16440	COG2084	Dehydrogenase
GPY04_RS16445	COG0217	transcriptional regulatory protein
GPY04_RS16480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY04_RS16485	COG1444	tRNA N-acetyltransferase activity
GPY04_RS16515	COG0745	RESPONSE REGULATOR receiver
GPY04_RS16520	COG0642	Histidine kinase
GPY04_RS16525	COG2194	sulfuric ester hydrolase activity
GPY04_RS16535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY04_RS16540	COG0601	transmembrane transport
GPY04_RS16560	COG2198	Histidine kinase
GPY04_RS16560	COG0643	Histidine kinase
GPY04_RS16565	COG0835	chemotaxis
GPY04_RS16570	COG0835	chemotaxis
GPY04_RS16575	COG0840	transmembrane signaling receptor activity
GPY04_RS16580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY04_RS16585	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPY04_RS16605	COG0745	RESPONSE REGULATOR receiver
GPY04_RS16635	COG0259	pyridoxamine-phosphate oxidase activity
GPY04_RS16645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY04_RS16670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY04_RS16700	COG1982	Orn Lys Arg decarboxylase major
GPY04_RS16705	COG0531	amino acid
GPY04_RS16715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY04_RS16720	COG1901	pseudouridine methyltransferase
GPY04_RS16730	COG4221	oxidoreductase activity
GPY04_RS16735	COG0840	transmembrane signaling receptor activity
GPY04_RS16745	COG2910	NAD(P)H-binding
GPY04_RS16775	COG0673	inositol 2-dehydrogenase activity
GPY04_RS16780	COG3722	fumarate hydratase activity
GPY04_RS16785	COG0246	Mannitol dehydrogenase
GPY04_RS16790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY04_RS16790	COG2213	PTS system mannitol-specific
GPY04_RS16800	COG0739	heme binding
GPY04_RS16810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY04_RS16815	COG4597	amino acid ABC transporter
GPY04_RS16820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY04_RS16830	COG1126	abc transporter atp-binding protein
GPY04_RS16835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY04_RS16845	COG0840	transmembrane signaling receptor activity
GPY04_RS16860	COG0840	transmembrane signaling receptor activity
GPY04_RS16875	COG4580	involved in the transport of maltose and maltodextrins
GPY04_RS16890	COG0363	glucosamine-6-phosphate deaminase activity
GPY04_RS16915	COG2259	Doxx family
GPY04_RS16920	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY04_RS16925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY04_RS16935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY04_RS16940	COG3366	ferrous iron transmembrane transporter activity
GPY04_RS16945	COG0700	Nucleoside recognition
GPY04_RS16955	COG0697	spore germination
GPY04_RS16960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY04_RS16965	COG1764	response to oxidative stress
GPY04_RS16970	COG1846	Transcriptional regulator
GPY04_RS16990	COG2207	Transcriptional regulator
GPY04_RS16995	COG1280	lysine exporter protein (LysE YggA)
GPY04_RS17005	COG1902	pentaerythritol trinitrate reductase activity
GPY04_RS17015	COG1132	(ABC) transporter
GPY04_RS17025	COG1902	pentaerythritol trinitrate reductase activity
GPY04_RS17035	COG0583	DNA-binding transcription factor activity
GPY04_RS17040	COG0513	Belongs to the DEAD box helicase family
GPY04_RS17050	COG0840	transmembrane signaling receptor activity
GPY04_RS17060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY04_RS17070	COG1304	FMN binding
GPY04_RS17075	COG1620	l-lactate permease
GPY04_RS17080	COG0583	DNA-binding transcription factor activity
GPY04_RS17105	COG4172	Belongs to the ABC transporter superfamily
GPY04_RS17115	COG1067	ATP-dependent peptidase activity
GPY04_RS17120	COG0840	transmembrane signaling receptor activity
GPY04_RS17130	COG2211	Major facilitator Superfamily
GPY04_RS17140	COG3123	guanosine phosphorylase activity
GPY04_RS17145	COG1741	Belongs to the pirin family
GPY04_RS17155	COG5001	Diguanylate cyclase
GPY04_RS17160	COG0583	DNA-binding transcription factor activity
GPY04_RS17195	COG3706	GGDEF domain
GPY04_RS17200	COG1846	Transcriptional regulator
GPY04_RS17205	COG0784	Response regulator, receiver
GPY04_RS17205	COG0835	chemotaxis
GPY04_RS17210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY04_RS17215	COG2197	response regulator
GPY04_RS17220	COG0393	Putative heavy-metal-binding
GPY04_RS17235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY04_RS17240	COG3842	ATPase activity
GPY04_RS17250	COG1175	transmembrane transport
GPY04_RS17255	COG3833	ABC-type maltose transport systems, permease component
GPY04_RS17270	COG1349	DNA-binding transcription factor activity
GPY04_RS17275	COG3706	GGDEF domain
GPY04_RS17300	COG1278	Cold shock
GPY04_RS17305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY04_RS17310	COG2354	Protein conserved in bacteria
GPY04_RS17315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY04_RS17325	COG3152	Membrane
GPY04_RS17335	COG0418	dihydroorotase activity
GPY04_RS17340	COG0633	Ferredoxin
GPY04_RS17340	COG3217	Mosc domain protein beta barrel domain protein
GPY04_RS17340	COG0633	Ferredoxin
GPY04_RS17340	COG3217	Mosc domain protein beta barrel domain protein
GPY04_RS17375	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY04_RS17380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY04_RS17385	COG4558	Periplasmic binding protein
GPY04_RS17390	COG0848	biopolymer transport protein
GPY04_RS17395	COG0811	peptide transport
GPY04_RS17400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY04_RS17410	COG3721	Heme iron utilization protein
GPY04_RS17415	COG0748	coenzyme F420 binding
GPY04_RS17425	COG3835	regulator
GPY04_RS17430	COG2610	gluconate transmembrane transporter activity
GPY04_RS17435	COG1929	Belongs to the glycerate kinase type-1 family
GPY04_RS17460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY04_RS17465	COG0363	glucosamine-6-phosphate deaminase activity
GPY04_RS17470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY04_RS17475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY04_RS17480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY04_RS17500	COG0346	lactoylglutathione lyase activity
GPY04_RS17525	COG1063	alcohol dehydrogenase
GPY04_RS17570	COG0583	DNA-binding transcription factor activity
GPY04_RS17575	COG3048	D-serine ammonia-lyase activity
GPY04_RS17590	COG1294	oxidase, subunit
GPY04_RS17595	COG1271	oxidase subunit
GPY04_RS17600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY04_RS17605	COG1686	Belongs to the peptidase S11 family
GPY04_RS17615	COG3047	cAMP biosynthetic process
GPY04_RS17625	COG3227	Zinc metalloprotease (Elastase)
GPY04_RS17635	COG2267	carboxylic ester hydrolase activity
GPY04_RS17640	COG2067	long-chain fatty acid transport protein
GPY04_RS17650	COG0366	Alpha amylase catalytic
GPY04_RS17655	COG4989	oxidoreductase activity
GPY04_RS17670	COG1136	(ABC) transporter
GPY04_RS17675	COG1136	(ABC) transporter
GPY04_RS17675	COG0577	efflux transmembrane transporter activity
GPY04_RS17690	COG3275	phosphorelay sensor kinase activity
GPY04_RS17695	COG3279	Response regulator of the LytR AlgR family
GPY04_RS17705	COG3706	GGDEF domain
GPY04_RS17710	COG0531	amino acid
GPY04_RS17735	COG1765	OsmC-like protein
GPY04_RS17740	COG1253	flavin adenine dinucleotide binding
GPY04_RS17745	COG2171	N-acyltransferase activity
GPY04_RS17760	COG0583	DNA-binding transcription factor activity
GPY04_RS17765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY04_RS17780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY04_RS17785	COG3186	Phenylalanine-4-hydroxylase
GPY04_RS17790	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY04_RS17795	COG0456	acetyltransferase
GPY04_RS17800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY04_RS17805	COG0662	Cupin 2, conserved barrel domain protein
GPY04_RS17810	COG0527	aspartate kinase activity
GPY04_RS17820	COG0459	protein refolding
GPY04_RS17825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY04_RS17830	COG2239	Acts as a magnesium transporter
GPY04_RS17845	COG1166	arginine decarboxylase activity
GPY04_RS17850	COG0010	Belongs to the arginase family
GPY04_RS17860	COG3227	Zinc metalloprotease (Elastase)
GPY04_RS17865	COG3397	chitin binding
GPY04_RS17870	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY04_RS17880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY04_RS17890	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY04_RS17895	COG0513	Belongs to the DEAD box helicase family
GPY04_RS17905	COG1368	sulfuric ester hydrolase activity
GPY04_RS17910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY04_RS17925	COG0546	phosphoglycolate phosphatase activity
GPY04_RS17965	COG0484	heat shock protein binding
GPY04_RS17980	COG1716	ATPase activity
GPY04_RS17980	COG5001	Diguanylate cyclase
GPY04_RS17985	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY04_RS17995	COG4181	ATPase activity
GPY04_RS18000	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY04_RS18015	COG1984	allophanate hydrolase subunit 2
GPY04_RS18025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY04_RS18030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY04_RS18035	COG0840	transmembrane signaling receptor activity
GPY04_RS18040	COG0814	amino acid
GPY04_RS18050	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY04_RS18055	COG0513	Belongs to the DEAD box helicase family
GPY04_RS18060	COG1309	transcriptional regulator
GPY04_RS18070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY04_RS18075	COG0494	nUDIX hydrolase
GPY04_RS18085	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY04_RS18095	COG1126	abc transporter atp-binding protein
GPY04_RS18100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY04_RS18105	COG4215	(ABC) transporter
GPY04_RS18110	COG4160	amino acid transport
GPY04_RS18115	COG0583	DNA-binding transcription factor activity
GPY04_RS18145	COG3118	belongs to the thioredoxin family
GPY04_RS18150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY04_RS18155	COG0247	lactate metabolic process
GPY04_RS18160	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY04_RS18165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY04_RS18170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY04_RS18175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY04_RS18205	COG2827	Endonuclease containing a URI domain
GPY04_RS18215	COG1879	ABC-type sugar transport system periplasmic component
GPY04_RS18220	COG0784	Response regulator, receiver
GPY04_RS18220	COG5002	protein histidine kinase activity
GPY04_RS18265	COG1492	cobalamin metabolic process
GPY04_RS18270	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY04_RS18275	COG4149	molybdate abc transporter
GPY04_RS18280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY04_RS18310	COG1289	transmembrane transporter activity
GPY04_RS18315	COG0210	DNA helicase
GPY04_RS18330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY04_RS18335	COG1335	isochorismatase
GPY04_RS18340	COG1803	Methylglyoxal synthase
GPY04_RS18345	COG1879	ABC-type sugar transport system periplasmic component
GPY04_RS18350	COG0784	Response regulator, receiver
GPY04_RS18350	COG2205	protein histidine kinase activity
GPY04_RS18350	COG2198	Histidine kinase
GPY04_RS18355	COG0469	pyruvate kinase activity
GPY04_RS18360	COG2271	Major facilitator Superfamily
GPY04_RS18365	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY04_RS18370	COG4191	Histidine kinase
GPY04_RS18385	COG1979	alcohol dehydrogenase
GPY04_RS18395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY04_RS18400	COG3706	GGDEF domain
GPY04_RS18415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY04_RS18420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY04_RS18430	COG0183	Belongs to the thiolase family
GPY04_RS18440	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY04_RS18445	COG3842	ATPase activity
GPY04_RS18455	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY04_RS18460	COG2271	Major facilitator Superfamily
GPY04_RS18465	COG3851	Histidine kinase
GPY04_RS18470	COG2197	response regulator
GPY04_RS18475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY04_RS18495	COG0243	molybdopterin cofactor binding
GPY04_RS18505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY04_RS18510	COG3850	Histidine kinase
GPY04_RS18515	COG2197	response regulator
GPY04_RS18520	COG1609	Transcriptional regulator
GPY04_RS18540	COG1760	l-serine dehydratase
GPY04_RS18545	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY04_RS18550	COG0840	transmembrane signaling receptor activity
GPY04_RS18555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY04_RS18560	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY04_RS18565	COG2885	chlorophyll binding
GPY04_RS18575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY04_RS18580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY04_RS18585	COG1621	beta-fructofuranosidase activity
GPY04_RS18595	COG1263	PTS System
GPY04_RS18595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY04_RS18640	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY04_RS18650	COG0640	Transcriptional regulator
GPY04_RS18675	COG0778	Nitroreductase
GPY04_RS18680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY04_RS18685	COG0583	DNA-binding transcription factor activity
GPY04_RS18710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY04_RS18735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY04_RS18740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY04_RS18750	COG2390	Transcriptional regulator
GPY04_RS18755	COG2897	thiosulfate sulfurtransferase activity
GPY04_RS18765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY04_RS18775	COG0302	gtp cyclohydrolase
GPY04_RS18780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY04_RS18780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY04_RS18785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY04_RS18790	COG1970	mechanosensitive ion channel activity
GPY04_RS18795	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY04_RS18805	COG1011	Hydrolase
GPY04_RS18810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY04_RS18815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY04_RS18825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY04_RS18835	COG3842	ATPase activity
GPY04_RS18880	COG4166	transmembrane transport
GPY04_RS18885	COG4174	ABC transporter (Permease)
GPY04_RS18890	COG4239	(ABC) transporter, permease
GPY04_RS18895	COG4172	Belongs to the ABC transporter superfamily
GPY04_RS18900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY04_RS18915	COG0625	glutathione transferase activity
GPY04_RS18935	COG2050	protein possibly involved in aromatic compounds catabolism
GPY04_RS18950	COG4771	TonB-dependent receptor
GPY04_RS18950	COG1629	transport
GPY04_RS18955	COG0583	DNA-binding transcription factor activity
GPY04_RS18960	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY04_RS18960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY04_RS18960	COG1042	CoA-binding domain protein
GPY04_RS18970	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY04_RS18980	COG0023	Translation Initiation Factor
GPY04_RS19000	COG0745	RESPONSE REGULATOR receiver
GPY04_RS19010	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY04_RS19015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY04_RS19030	COG3706	GGDEF domain
GPY04_RS19085	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY04_RS19105	COG0737	Belongs to the 5'-nucleotidase family
GPY04_RS19110	COG3593	DNA synthesis involved in DNA repair
GPY04_RS19120	COG0583	DNA-binding transcription factor activity
GPY04_RS19125	COG2116	formate transmembrane transporter activity
GPY04_RS19135	COG3038	cytochrome b561
GPY04_RS19145	COG2200	EAL domain
GPY04_RS19155	COG0586	Pfam SNARE associated Golgi protein
GPY04_RS19160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY04_RS19165	COG0745	RESPONSE REGULATOR receiver
GPY04_RS19170	COG2205	protein histidine kinase activity
GPY04_RS19175	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY04_RS19175	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY04_RS19175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY04_RS19175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPY04_RS19180	COG3158	transport of potassium into the cell
GPY04_RS19190	COG0523	cobalamin synthesis protein
GPY04_RS19195	COG0038	chloride channel
GPY04_RS19205	COG0156	8-amino-7-oxononanoate synthase activity
GPY04_RS19210	COG0784	Response regulator, receiver
GPY04_RS19210	COG2205	protein histidine kinase activity
GPY04_RS19215	COG0419	ATPase involved in DNA repair
GPY04_RS19220	COG0420	3'-5' exonuclease activity
GPY04_RS19225	COG1609	Transcriptional regulator
GPY04_RS19230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY04_RS19230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY04_RS19235	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY04_RS19240	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY04_RS19240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY04_RS19240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY04_RS19245	COG4067	protein conserved in archaea
GPY04_RS19245	COG0189	ligase activity
GPY04_RS19255	COG0602	queuosine metabolic process
GPY04_RS19260	COG1328	CTP reductase activity
GPY04_RS19285	COG0346	lactoylglutathione lyase activity