locus-tag	class	description
ASZ81_RS00010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ81_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ASZ81_RS00020	COG0706	membrane insertase activity
ASZ81_RS00030	COG0594	ribonuclease P activity
ASZ81_RS00035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ASZ81_RS00040	COG1126	abc transporter atp-binding protein
ASZ81_RS00055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASZ81_RS00060	COG0592	DNA-directed DNA polymerase activity
ASZ81_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASZ81_RS00070	COG0187	DNA topoisomerase II activity
ASZ81_RS00085	COG0071	Belongs to the small heat shock protein (HSP20) family
ASZ81_RS00090	COG3977	Valine--pyruvate aminotransferase
ASZ81_RS00100	COG0751	glycine-tRNA ligase activity
ASZ81_RS00105	COG0752	glycyl-tRNA synthetase alpha subunit
ASZ81_RS00110	COG2119	membrane
ASZ81_RS00120	COG0425	Belongs to the sulfur carrier protein TusA family
ASZ81_RS00130	COG0604	alcohol dehydrogenase
ASZ81_RS00140	COG0129	dihydroxy-acid dehydratase activity
ASZ81_RS00145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASZ81_RS00160	COG0606	chelatase, subunit chli
ASZ81_RS00165	COG0204	Acyl-transferase
ASZ81_RS00170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASZ81_RS00175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ASZ81_RS00190	COG3084	Protein conserved in bacteria
ASZ81_RS00200	COG4326	sporulation control protein
ASZ81_RS00205	COG1272	protein, Hemolysin III
ASZ81_RS00215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASZ81_RS00220	COG0569	domain protein
ASZ81_RS00225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASZ81_RS00225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASZ81_RS00230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASZ81_RS00235	COG0242	peptide deformylase activity
ASZ81_RS00240	COG1652	LysM domain
ASZ81_RS00245	COG0758	DNA mediated transformation
ASZ81_RS00250	COG2922	Belongs to the Smg family
ASZ81_RS00255	COG0551	DNA topoisomerase type I activity
ASZ81_RS00260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ASZ81_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ASZ81_RS00270	COG0009	L-threonylcarbamoyladenylate synthase
ASZ81_RS00275	COG0408	coproporphyrinogen oxidase activity
ASZ81_RS00280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASZ81_RS00290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ASZ81_RS00330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASZ81_RS00335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASZ81_RS00345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASZ81_RS00350	COG2104	thiamine diphosphate biosynthetic process
ASZ81_RS00355	COG2022	thiamine diphosphate biosynthetic process
ASZ81_RS00360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASZ81_RS00365	COG0006	proline dipeptidase activity
ASZ81_RS00365	COG0006	proline dipeptidase activity
ASZ81_RS00385	COG1522	sequence-specific DNA binding
ASZ81_RS00390	COG5001	Diguanylate cyclase
ASZ81_RS00390	COG5002	protein histidine kinase activity
ASZ81_RS00410	COG0589	response to stress
ASZ81_RS00420	COG1528	Iron-storage protein
ASZ81_RS00430	COG2081	HI0933 family
ASZ81_RS00440	COG1322	Protein conserved in bacteria
ASZ81_RS00445	COG2226	methyltransferase
ASZ81_RS00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASZ81_RS00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASZ81_RS00470	COG0805	protein transport
ASZ81_RS00475	COG1858	cytochrome C peroxidase
ASZ81_RS00480	COG0534	Mate efflux family protein
ASZ81_RS00490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ASZ81_RS00505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASZ81_RS00510	COG3161	chorismate lyase activity
ASZ81_RS00520	COG1580	Controls the rotational direction of flagella during chemotaxis
ASZ81_RS00525	COG0840	transmembrane signaling receptor activity
ASZ81_RS00535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASZ81_RS00545	COG0084	hydrolase, TatD family'
ASZ81_RS00560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASZ81_RS00560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASZ81_RS00580	COG3078	GTPase activator activity
ASZ81_RS00595	COG3071	HemY protein
ASZ81_RS00600	COG2959	enzyme of heme biosynthesis
ASZ81_RS00605	COG1587	Uroporphyrinogen-III synthase
ASZ81_RS00610	COG0181	hydroxymethylbilane synthase activity
ASZ81_RS00625	COG1965	Belongs to the frataxin family
ASZ81_RS00635	COG0019	diaminopimelate decarboxylase activity
ASZ81_RS00640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ASZ81_RS00650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ASZ81_RS00655	COG1011	Hydrolase
ASZ81_RS00660	COG3287	FIST C domain
ASZ81_RS00660	COG2200	EAL domain
ASZ81_RS00660	COG2199	diguanylate cyclase activity
ASZ81_RS00680	COG0561	phosphatase activity
ASZ81_RS00685	COG2267	carboxylic ester hydrolase activity
ASZ81_RS00690	COG1280	lysine exporter protein (LysE YggA)
ASZ81_RS00695	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ASZ81_RS00700	COG0783	Belongs to the Dps family
ASZ81_RS00740	COG0742	ribosomal rna small subunit methyltransferase
ASZ81_RS00745	COG0552	protein localization to endoplasmic reticulum
ASZ81_RS00750	COG2884	Cell division ATP-binding protein ftsE
ASZ81_RS00755	COG2177	Part of the ABC transporter FtsEX involved in
ASZ81_RS00760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASZ81_RS00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ81_RS00785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASZ81_RS00790	COG4206	TonB-dependent receptor
ASZ81_RS00795	COG1404	Belongs to the peptidase S8 family
ASZ81_RS00800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASZ81_RS00835	COG0583	DNA-binding transcription factor activity
ASZ81_RS00840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASZ81_RS00845	COG2960	long-chain fatty acid transporting porin activity
ASZ81_RS00850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASZ81_RS00855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ81_RS00860	COG1309	transcriptional regulator
ASZ81_RS00910	COG0747	negative chemotaxis
ASZ81_RS00915	COG0601	transmembrane transport
ASZ81_RS00920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASZ81_RS00930	COG2131	deaminase
ASZ81_RS00955	COG3621	Patatin-like phospholipase
ASZ81_RS00995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ81_RS01000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ASZ81_RS01010	COG0210	DNA helicase
ASZ81_RS01015	COG1280	lysine exporter protein (LysE YggA)
ASZ81_RS01030	COG2962	Rard protein
ASZ81_RS01035	COG0514	ATP-dependent DNA helicase (RecQ)
ASZ81_RS01050	COG1132	(ABC) transporter
ASZ81_RS01055	COG4774	siderophore transport
ASZ81_RS01060	COG1120	ATPase activity
ASZ81_RS01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASZ81_RS01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ81_RS01090	COG1263	PTS System
ASZ81_RS01095	COG2862	Uncharacterized protein family, UPF0114
ASZ81_RS01100	COG1561	YicC-like family, N-terminal region
ASZ81_RS01105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASZ81_RS01110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASZ81_RS01115	COG1560	Kdo2-lipid A biosynthetic process
ASZ81_RS01120	COG1560	Kdo2-lipid A biosynthetic process
ASZ81_RS01125	COG1309	transcriptional regulator
ASZ81_RS01135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ASZ81_RS01145	COG2003	Belongs to the UPF0758 family
ASZ81_RS01150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASZ81_RS01155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASZ81_RS01165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASZ81_RS01170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASZ81_RS01175	COG0859	PFAM glycosyl transferase family 9
ASZ81_RS01180	COG0463	Glycosyl transferase, family 2
ASZ81_RS01185	COG0859	PFAM glycosyl transferase family 9
ASZ81_RS01190	COG3642	lipopolysaccharide core region biosynthetic process
ASZ81_RS01220	COG1519	Transferase
ASZ81_RS01255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASZ81_RS01260	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ASZ81_RS01260	COG0662	Cupin 2, conserved barrel domain protein
ASZ81_RS01265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASZ81_RS01270	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ASZ81_RS01300	COG0318	PFAM AMP-dependent synthetase and ligase
ASZ81_RS01305	COG1012	belongs to the aldehyde dehydrogenase family
ASZ81_RS01305	COG1454	alcohol dehydrogenase
ASZ81_RS01325	COG5433	transposase activity
ASZ81_RS01355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASZ81_RS01360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASZ81_RS01365	COG0668	transmembrane transport
ASZ81_RS01370	COG1573	uracil-dna glycosylase
ASZ81_RS01380	COG3068	Protein conserved in bacteria
ASZ81_RS01390	COG1940	carbohydrate kinase activity
ASZ81_RS01395	COG1253	flavin adenine dinucleotide binding
ASZ81_RS01405	COG0776	regulation of translation
ASZ81_RS01415	COG0151	Belongs to the GarS family
ASZ81_RS01430	COG0789	Transcriptional regulator
ASZ81_RS01435	COG3710	Transcriptional regulator
ASZ81_RS01440	COG0531	amino acid
ASZ81_RS01445	COG1982	Orn Lys Arg decarboxylase major
ASZ81_RS01450	COG0840	transmembrane signaling receptor activity
ASZ81_RS01465	COG0800	Aldolase
ASZ81_RS01475	COG3265	gluconokinase activity
ASZ81_RS01480	COG0129	dihydroxy-acid dehydratase activity
ASZ81_RS01485	COG1609	Transcriptional regulator
ASZ81_RS01490	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ASZ81_RS01495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASZ81_RS01500	COG2264	protein methyltransferase activity
ASZ81_RS01505	COG0439	Biotin carboxylase
ASZ81_RS01510	COG0511	ligase activity, forming carbon-carbon bonds
ASZ81_RS01515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ASZ81_RS01520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASZ81_RS01535	COG2814	Major facilitator Superfamily
ASZ81_RS01540	COG2205	protein histidine kinase activity
ASZ81_RS01540	COG0784	Response regulator, receiver
ASZ81_RS01545	COG0248	Ppx GppA phosphatase
ASZ81_RS01550	COG0513	Belongs to the DEAD box helicase family
ASZ81_RS01555	COG3118	belongs to the thioredoxin family
ASZ81_RS01570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASZ81_RS01620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASZ81_RS01635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASZ81_RS01645	COG1072	(Pantothenic acid kinase))
ASZ81_RS01670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASZ81_RS01675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASZ81_RS01680	COG0250	Participates in transcription elongation, termination and antitermination
ASZ81_RS01685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASZ81_RS01695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ASZ81_RS01700	COG0222	ribosome binding
ASZ81_RS01705	COG0085	RNA polymerase activity
ASZ81_RS01710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASZ81_RS01715	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ASZ81_RS01720	COG2816	NAD+ diphosphatase activity
ASZ81_RS01725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASZ81_RS01740	COG4942	peptidase
ASZ81_RS01745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ASZ81_RS01755	COG0471	metal ion transport
ASZ81_RS01760	COG0688	phosphatidylethanolamine metabolic process
ASZ81_RS01765	COG1162	GTPase activity
ASZ81_RS01770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ASZ81_RS01815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ASZ81_RS01820	COG0802	atpase or kinase
ASZ81_RS01830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ASZ81_RS01835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASZ81_RS01840	COG1923	regulation of RNA biosynthetic process
ASZ81_RS01845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASZ81_RS01850	COG0330	HflC and HflK could
ASZ81_RS01855	COG0330	HflC and HflK could
ASZ81_RS01860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ASZ81_RS01865	COG2900	Belongs to the SlyX family
ASZ81_RS01875	COG0545	Peptidyl-prolyl cis-trans isomerase
ASZ81_RS01880	COG2964	Protein conserved in bacteria
ASZ81_RS01885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ASZ81_RS01890	COG2923	Belongs to the DsrF TusC family
ASZ81_RS01905	COG0049	tRNA binding
ASZ81_RS01910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ81_RS01915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASZ81_RS01920	COG2906	2 iron, 2 sulfur cluster binding
ASZ81_RS01930	COG0360	Binds together with S18 to 16S ribosomal RNA
ASZ81_RS01935	COG2965	DNA replication, synthesis of RNA primer
ASZ81_RS01940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASZ81_RS01945	COG0359	binds to the 23S rRNA
ASZ81_RS01960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASZ81_RS01965	COG0432	Pfam Uncharacterised protein family UPF0047
ASZ81_RS01985	COG0735	belongs to the Fur family
ASZ81_RS01990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASZ81_RS02015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ81_RS02025	COG0175	sulfate reduction
ASZ81_RS02100	COG1410	methionine synthase
ASZ81_RS02100	COG0646	methionine synthase
ASZ81_RS02105	COG0527	aspartate kinase activity
ASZ81_RS02110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASZ81_RS02120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASZ81_RS02135	COG0629	single-stranded DNA binding
ASZ81_RS02140	COG2200	EAL domain
ASZ81_RS02140	COG2199	diguanylate cyclase activity
ASZ81_RS02165	COG3409	Peptidoglycan-binding domain 1 protein
ASZ81_RS02165	COG3267	Type II secretory pathway component ExeA
ASZ81_RS02175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASZ81_RS02180	COG1459	type II secretion system
ASZ81_RS02190	COG2165	general secretion pathway protein
ASZ81_RS02195	COG2165	general secretion pathway protein
ASZ81_RS02225	COG1077	Cell shape determining protein MreB Mrl
ASZ81_RS02230	COG1792	Involved in formation and maintenance of cell shape
ASZ81_RS02235	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ASZ81_RS02240	COG0424	maF-like protein
ASZ81_RS02250	COG3164	Protein of unknown function
ASZ81_RS02255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASZ81_RS02260	COG0312	modulator of DNA gyrase
ASZ81_RS02265	COG2235	arginine
ASZ81_RS02285	COG0589	response to stress
ASZ81_RS02295	COG2358	TRAP transporter, solute receptor (TAXI family
ASZ81_RS02305	COG1438	arginine binding
ASZ81_RS02310	COG0039	L-malate dehydrogenase activity
ASZ81_RS02315	COG0531	amino acid
ASZ81_RS02320	COG0142	geranyltranstransferase activity
ASZ81_RS02325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASZ81_RS02330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASZ81_RS02335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASZ81_RS02340	COG2966	Psort location CytoplasmicMembrane, score
ASZ81_RS02345	COG3610	response to peptide
ASZ81_RS02355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASZ81_RS02360	COG2967	ApaG domain
ASZ81_RS02365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASZ81_RS02370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ASZ81_RS02375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASZ81_RS02380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ASZ81_RS02385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ASZ81_RS02440	COG0741	lytic transglycosylase activity
ASZ81_RS02445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ASZ81_RS02450	COG1194	a g-specific adenine glycosylase
ASZ81_RS02460	COG2066	Belongs to the glutaminase family
ASZ81_RS02465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASZ81_RS02470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASZ81_RS02480	COG1872	DUF167
ASZ81_RS02485	COG0762	integral membrane protein
ASZ81_RS02490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASZ81_RS02495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ASZ81_RS02515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASZ81_RS02520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ASZ81_RS02525	COG1678	Uncharacterized ACR, COG1678
ASZ81_RS02530	COG0189	ligase activity
ASZ81_RS02535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ASZ81_RS02540	COG2356	endonuclease I
ASZ81_RS02550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASZ81_RS02560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ASZ81_RS02565	COG0583	DNA-binding transcription factor activity
ASZ81_RS02570	COG4771	TonB-dependent receptor
ASZ81_RS02575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASZ81_RS02580	COG0126	phosphoglycerate kinase activity
ASZ81_RS02585	COG0191	fructose-bisphosphate aldolase activity
ASZ81_RS02595	COG0668	transmembrane transport
ASZ81_RS02600	COG1279	arginine transmembrane transporter activity
ASZ81_RS02620	COG1349	DNA-binding transcription factor activity
ASZ81_RS02625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASZ81_RS02630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ASZ81_RS02680	COG0328	RNA-DNA hybrid ribonuclease activity
ASZ81_RS02700	COG4969	Belongs to the N-Me-Phe pilin family
ASZ81_RS02710	COG0739	heme binding
ASZ81_RS02745	COG2003	Belongs to the UPF0758 family
ASZ81_RS02760	COG0840	transmembrane signaling receptor activity
ASZ81_RS02765	COG2207	Transcriptional regulator
ASZ81_RS02775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ASZ81_RS02780	COG0582	viral genome integration into host DNA
ASZ81_RS02795	COG0358	DNA primase activity
ASZ81_RS02800	COG1610	YqeY-like protein
ASZ81_RS02805	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ASZ81_RS02810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASZ81_RS02820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ASZ81_RS02830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASZ81_RS02835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASZ81_RS02840	COG1968	undecaprenyl-diphosphatase activity
ASZ81_RS02845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ASZ81_RS02850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASZ81_RS02855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ASZ81_RS02860	COG0585	pseudouridine synthase activity
ASZ81_RS02865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ASZ81_RS02870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASZ81_RS02880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASZ81_RS02885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ASZ81_RS02905	COG4208	sulfate ABC transporter
ASZ81_RS02910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ASZ81_RS02920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ASZ81_RS02930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASZ81_RS02935	COG0527	aspartate kinase activity
ASZ81_RS02940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ASZ81_RS02985	COG3630	sodium ion export across plasma membrane
ASZ81_RS02990	COG5016	pyruvate
ASZ81_RS02990	COG0511	ligase activity, forming carbon-carbon bonds
ASZ81_RS02995	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ASZ81_RS03005	COG1238	metal cluster binding
ASZ81_RS03010	COG0612	Peptidase, M16
ASZ81_RS03015	COG2918	glutathione biosynthetic process
ASZ81_RS03020	COG1854	S-ribosylhomocysteine lyase activity
ASZ81_RS03025	COG4536	flavin adenine dinucleotide binding
ASZ81_RS03030	COG4137	Cytochrome C assembly protein
ASZ81_RS03035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASZ81_RS03040	COG0228	four-way junction DNA binding
ASZ81_RS03045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASZ81_RS03050	COG0336	Belongs to the RNA methyltransferase TrmD family
ASZ81_RS03055	COG0335	large ribosomal subunit rRNA binding
ASZ81_RS03060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASZ81_RS03065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASZ81_RS03075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ASZ81_RS03085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASZ81_RS03090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASZ81_RS03095	COG0723	plastoquinol--plastocyanin reductase activity
ASZ81_RS03100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASZ81_RS03105	COG2857	Cytochrome c1
ASZ81_RS03110	COG0625	glutathione transferase activity
ASZ81_RS03115	COG2969	positive regulation of protein catabolic process
ASZ81_RS03120	COG2823	Periplasmic or secreted lipoprotein
ASZ81_RS03125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASZ81_RS03130	COG0792	nuclease activity
ASZ81_RS03135	COG3107	peptidoglycan biosynthetic process
ASZ81_RS03140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ASZ81_RS03160	COG0288	reversible hydration of carbon dioxide
ASZ81_RS03165	COG0659	secondary active sulfate transmembrane transporter activity
ASZ81_RS03170	COG1131	(ABC) transporter
ASZ81_RS03175	COG0842	Transport permease protein
ASZ81_RS03180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ASZ81_RS03185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASZ81_RS03190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASZ81_RS03200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASZ81_RS03210	COG1489	DNA binding
ASZ81_RS03220	COG1643	Atp-dependent helicase
ASZ81_RS03225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASZ81_RS03230	COG1752	Esterase of the alpha-beta hydrolase superfamily
ASZ81_RS03235	COG1049	propionate catabolic process, 2-methylcitrate cycle
ASZ81_RS03240	COG3112	Uncharacterised protein family (UPF0231)
ASZ81_RS03245	COG0347	Belongs to the P(II) protein family
ASZ81_RS03250	COG0004	ammonium transporteR
ASZ81_RS03255	COG1840	ABC-type Fe3 transport system, periplasmic component
ASZ81_RS03265	COG3842	ATPase activity
ASZ81_RS03285	COG2971	BadF BadG BcrA BcrD
ASZ81_RS03295	COG4608	Belongs to the ABC transporter superfamily
ASZ81_RS03300	COG0444	Belongs to the ABC transporter superfamily
ASZ81_RS03305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASZ81_RS03310	COG0601	transmembrane transport
ASZ81_RS03315	COG0747	negative chemotaxis
ASZ81_RS03325	COG2205	protein histidine kinase activity
ASZ81_RS03325	COG0784	Response regulator, receiver
ASZ81_RS03330	COG2813	Specifically methylates the guanine in position
ASZ81_RS03335	COG0628	permease
ASZ81_RS03345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASZ81_RS03350	COG0316	Belongs to the HesB IscA family
ASZ81_RS03365	COG0739	heme binding
ASZ81_RS03370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASZ81_RS03375	COG2027	D-alanyl-D-alanine carboxypeptidase
ASZ81_RS03380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ASZ81_RS03385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASZ81_RS03390	COG1534	Rna-binding protein
ASZ81_RS03395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ASZ81_RS03400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASZ81_RS03405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASZ81_RS03420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASZ81_RS03435	COG0779	Required for maturation of 30S ribosomal subunits
ASZ81_RS03440	COG0195	Participates in both transcription termination and antitermination
ASZ81_RS03445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASZ81_RS03450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASZ81_RS03460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASZ81_RS03485	COG0826	peptidase U32
ASZ81_RS03490	COG0826	peptidase U32
ASZ81_RS03500	COG3154	lipid carrier protein
ASZ81_RS03505	COG3153	acetyltransferase
ASZ81_RS03530	COG0513	Belongs to the DEAD box helicase family
ASZ81_RS03545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASZ81_RS03550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASZ81_RS03555	COG2204	response regulator
ASZ81_RS03565	COG0667	Aldo Keto reductase
ASZ81_RS03575	COG0494	nUDIX hydrolase
ASZ81_RS03580	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ASZ81_RS03585	COG0730	response to heat
ASZ81_RS03590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASZ81_RS03600	COG1283	sodium-dependent phosphate transmembrane transporter activity
ASZ81_RS03605	COG0583	DNA-binding transcription factor activity
ASZ81_RS03610	COG0640	Transcriptional regulator
ASZ81_RS03615	COG0268	Binds directly to 16S ribosomal RNA
ASZ81_RS03620	COG0728	peptidoglycan biosynthetic process
ASZ81_RS03625	COG0196	riboflavin kinase activity
ASZ81_RS03640	COG1047	Peptidyl-prolyl cis-trans
ASZ81_RS03645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASZ81_RS03650	COG1966	Carbon starvation protein
ASZ81_RS03665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASZ81_RS03670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ASZ81_RS03680	COG3279	Response regulator of the LytR AlgR family
ASZ81_RS03685	COG3275	phosphorelay sensor kinase activity
ASZ81_RS03690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASZ81_RS03695	COG1605	Chorismate mutase
ASZ81_RS03695	COG0287	Prephenate dehydrogenase
ASZ81_RS03705	COG0488	(ABC) transporter
ASZ81_RS03715	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ASZ81_RS03725	COG5001	Diguanylate cyclase
ASZ81_RS03730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ASZ81_RS03735	COG1605	Chorismate mutase
ASZ81_RS03735	COG0077	Prephenate dehydratase
ASZ81_RS03740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASZ81_RS03745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASZ81_RS03750	COG0564	pseudouridine synthase activity
ASZ81_RS03760	COG0542	response to heat
ASZ81_RS03805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASZ81_RS03810	COG0826	peptidase U32
ASZ81_RS03820	COG0745	RESPONSE REGULATOR receiver
ASZ81_RS03825	COG5002	protein histidine kinase activity
ASZ81_RS03835	COG0248	Ppx GppA phosphatase
ASZ81_RS03840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASZ81_RS03850	COG0581	inorganic phosphate transmembrane transporter activity
ASZ81_RS03855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASZ81_RS03870	COG3142	Participates in the control of copper homeostasis
ASZ81_RS03875	COG0450	alkyl hydroperoxide reductase
ASZ81_RS03880	COG0583	DNA-binding transcription factor activity
ASZ81_RS03885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASZ81_RS03895	COG0517	IMP dehydrogenase activity
ASZ81_RS03915	COG1862	Preprotein translocase
ASZ81_RS03920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASZ81_RS03925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASZ81_RS03930	COG0483	inositol monophosphate 1-phosphatase activity
ASZ81_RS03940	COG1959	2 iron, 2 sulfur cluster binding
ASZ81_RS03945	COG1104	cysteine desulfurase activity
ASZ81_RS03950	COG0822	iron-sulfur transferase activity
ASZ81_RS03960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ASZ81_RS03965	COG0443	Heat shock 70 kDa protein
ASZ81_RS03970	COG0633	Ferredoxin
ASZ81_RS03975	COG2975	iron-sulfur cluster assembly
ASZ81_RS03980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASZ81_RS03985	COG0105	UTP biosynthetic process
ASZ81_RS03990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ASZ81_RS04000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASZ81_RS04005	COG0124	histidyl-tRNA synthetase
ASZ81_RS04010	COG2976	Protein conserved in bacteria
ASZ81_RS04015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASZ81_RS04020	COG1160	GTP binding
ASZ81_RS04035	COG1570	exodeoxyribonuclease VII activity
ASZ81_RS04040	COG0516	GMP reductase activity
ASZ81_RS04040	COG0517	IMP dehydrogenase activity
ASZ81_RS04045	COG0519	Catalyzes the synthesis of GMP from XMP
ASZ81_RS04045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASZ81_RS04055	COG1584	GPR1 FUN34 yaaH family protein
ASZ81_RS04060	COG1535	isochorismatase
ASZ81_RS04060	COG3433	isochorismatase activity
ASZ81_RS04065	COG1021	2,3-dihydroxybenzoate-AMP ligase
ASZ81_RS04070	COG1169	isochorismate synthase
ASZ81_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
ASZ81_RS04085	COG4592	Periplasmic binding protein
ASZ81_RS04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASZ81_RS04095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASZ81_RS04100	COG1120	ATPase activity
ASZ81_RS04110	COG0583	DNA-binding transcription factor activity
ASZ81_RS04115	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ASZ81_RS04120	COG1115	amino acid carrier protein
ASZ81_RS04130	COG0583	DNA-binding transcription factor activity
ASZ81_RS04145	COG4565	transcriptional regulatory protein
ASZ81_RS04155	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ASZ81_RS04160	COG5016	pyruvate
ASZ81_RS04160	COG0511	ligase activity, forming carbon-carbon bonds
ASZ81_RS04165	COG3630	sodium ion export across plasma membrane
ASZ81_RS04175	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ASZ81_RS04185	COG2301	Belongs to the HpcH HpaI aldolase family
ASZ81_RS04190	COG3051	citrate lyase alpha subunit
ASZ81_RS04210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASZ81_RS04215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ASZ81_RS04220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ASZ81_RS04285	COG1012	belongs to the aldehyde dehydrogenase family
ASZ81_RS04305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ASZ81_RS04310	COG0840	transmembrane signaling receptor activity
ASZ81_RS04325	COG2165	general secretion pathway protein
ASZ81_RS04340	COG4796	Type ii and iii secretion system protein
ASZ81_RS04360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASZ81_RS04365	COG1459	type II secretion system
ASZ81_RS04375	COG2207	Transcriptional regulator
ASZ81_RS04380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ASZ81_RS04400	COG0739	heme binding
ASZ81_RS04410	COG3064	Membrane
ASZ81_RS04415	COG0582	viral genome integration into host DNA
ASZ81_RS04435	COG0582	viral genome integration into host DNA
ASZ81_RS04445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASZ81_RS04450	COG2867	negative regulation of translational initiation
ASZ81_RS04455	COG2914	Belongs to the UPF0125 (RnfH) family
ASZ81_RS04460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASZ81_RS04465	COG0497	DNA recombination
ASZ81_RS04470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASZ81_RS04475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASZ81_RS04480	COG0443	Heat shock 70 kDa protein
ASZ81_RS04485	COG0484	heat shock protein binding
ASZ81_RS04520	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ASZ81_RS04535	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ASZ81_RS04545	COG0047	phosphoribosylformylglycinamidine synthase activity
ASZ81_RS04545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASZ81_RS04575	COG0442	prolyl-tRNA aminoacylation
ASZ81_RS04580	COG1720	tRNA m6t6A37 methyltransferase activity
ASZ81_RS04585	COG0254	rRNA binding
ASZ81_RS04590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASZ81_RS04595	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ASZ81_RS04600	COG1671	Belongs to the UPF0178 family
ASZ81_RS04610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASZ81_RS04625	COG3098	single-species biofilm formation
ASZ81_RS04630	COG0564	pseudouridine synthase activity
ASZ81_RS04635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASZ81_RS04640	COG0142	geranyltranstransferase activity
ASZ81_RS04645	COG1722	exodeoxyribonuclease VII activity
ASZ81_RS04650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ASZ81_RS04660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASZ81_RS04660	COG0301	tRNA thio-modification
ASZ81_RS04670	COG0583	DNA-binding transcription factor activity
ASZ81_RS04675	COG2363	Small membrane protein
ASZ81_RS04680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASZ81_RS04685	COG1611	Belongs to the LOG family
ASZ81_RS04700	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASZ81_RS04700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASZ81_RS04710	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ASZ81_RS04715	COG1464	Belongs to the NlpA lipoprotein family
ASZ81_RS04720	COG2011	ABC-type metal ion transport system permease component
ASZ81_RS04725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASZ81_RS04730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASZ81_RS04735	COG1609	Transcriptional regulator
ASZ81_RS04740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ81_RS04740	COG1263	PTS System
ASZ81_RS04745	COG0366	Alpha amylase catalytic
ASZ81_RS04775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASZ81_RS04780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASZ81_RS04785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ASZ81_RS04790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ASZ81_RS04795	COG0110	maltose O-acetyltransferase activity
ASZ81_RS04815	COG1045	serine acetyltransferase
ASZ81_RS04825	COG0438	transferase activity, transferring glycosyl groups
ASZ81_RS04835	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ASZ81_RS04865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASZ81_RS04875	COG1596	polysaccharide export
ASZ81_RS04900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASZ81_RS04910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASZ81_RS04915	COG0321	lipoyl(octanoyl) transferase activity
ASZ81_RS04920	COG2921	Belongs to the UPF0250 family
ASZ81_RS04925	COG1686	Belongs to the peptidase S11 family
ASZ81_RS04930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASZ81_RS04935	COG0772	Belongs to the SEDS family
ASZ81_RS04940	COG0768	penicillin binding
ASZ81_RS04945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ASZ81_RS04950	COG0799	negative regulation of ribosome biogenesis
ASZ81_RS04955	COG1466	dna polymerase III delta subunit
ASZ81_RS04960	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ASZ81_RS04965	COG0495	leucyl-tRNA aminoacylation
ASZ81_RS04970	COG2888	peptidyl-tyrosine sulfation
ASZ81_RS04975	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASZ81_RS04980	COG4535	Mg2 and Co2 transporter CorC
ASZ81_RS04990	COG1702	phosphate starvation-inducible protein PhoH
ASZ81_RS04995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASZ81_RS05000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ81_RS05005	COG2190	(PTS) system
ASZ81_RS05015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ81_RS05025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASZ81_RS05030	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ASZ81_RS05035	COG3115	cell septum assembly
ASZ81_RS05040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASZ81_RS05055	COG0789	Transcriptional regulator
ASZ81_RS05060	COG1585	Membrane protein implicated in regulation of membrane protease activity
ASZ81_RS05065	COG0330	HflC and HflK could
ASZ81_RS05075	COG3118	belongs to the thioredoxin family
ASZ81_RS05080	COG0300	oxidoreductase activity
ASZ81_RS05085	COG1090	epimerase
ASZ81_RS05090	COG0622	Phosphoesterase
ASZ81_RS05105	COG3710	Transcriptional regulator
ASZ81_RS05110	COG0326	Molecular chaperone. Has ATPase activity
ASZ81_RS05115	COG0563	adenylate kinase activity
ASZ81_RS05120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASZ81_RS05135	COG0367	asparagine synthase
ASZ81_RS05140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ASZ81_RS05140	COG4651	solute:proton antiporter activity
ASZ81_RS05145	COG1940	carbohydrate kinase activity
ASZ81_RS05145	COG1846	Transcriptional regulator
ASZ81_RS05150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASZ81_RS05155	COG1263	PTS System
ASZ81_RS05155	COG2190	(PTS) system
ASZ81_RS05155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ81_RS05170	COG0101	tRNA pseudouridine synthase activity
ASZ81_RS05175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ASZ81_RS05180	COG0285	dihydrofolate synthase activity
ASZ81_RS05185	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ASZ81_RS05190	COG1286	toxin biosynthetic process
ASZ81_RS05195	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ASZ81_RS05200	COG2056	Na+-H+ antiporter family
ASZ81_RS05205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ASZ81_RS05225	COG0346	lactoylglutathione lyase activity
ASZ81_RS05230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ASZ81_RS05250	COG4656	Part of a membrane complex involved in electron transport
ASZ81_RS05255	COG2878	Part of a membrane complex involved in electron transport
ASZ81_RS05260	COG4657	Part of a membrane complex involved in electron transport
ASZ81_RS05270	COG0556	nucleotide-excision repair
ASZ81_RS05280	COG2204	response regulator
ASZ81_RS05285	COG2198	Histidine kinase
ASZ81_RS05290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ASZ81_RS05295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASZ81_RS05300	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASZ81_RS05305	COG0315	cyclic pyranopterin monophosphate synthase activity
ASZ81_RS05310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ASZ81_RS05315	COG0314	molybdopterin synthase activity
ASZ81_RS05320	COG2199	diguanylate cyclase activity
ASZ81_RS05325	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ASZ81_RS05325	COG0617	tRNA 3'-terminal CCA addition
ASZ81_RS05325	COG0517	IMP dehydrogenase activity
ASZ81_RS05340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ASZ81_RS05350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ81_RS05350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ81_RS05355	COG0489	protein tyrosine kinase activity
ASZ81_RS05365	COG0572	uridine kinase
ASZ81_RS05370	COG2982	Protein involved in outer membrane biogenesis
ASZ81_RS05375	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ASZ81_RS05380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASZ81_RS05390	COG2067	long-chain fatty acid transport protein
ASZ81_RS05410	COG0183	Belongs to the thiolase family
ASZ81_RS05415	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASZ81_RS05415	COG1024	Enoyl-CoA hydratase
ASZ81_RS05420	COG0778	Nitroreductase
ASZ81_RS05425	COG0583	DNA-binding transcription factor activity
ASZ81_RS05430	COG0745	RESPONSE REGULATOR receiver
ASZ81_RS05440	COG2832	Protein of unknown function (DUF454)
ASZ81_RS05445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASZ81_RS05455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASZ81_RS05460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASZ81_RS05470	COG2983	Belongs to the UPF0260 family
ASZ81_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
ASZ81_RS05480	COG0616	signal peptide processing
ASZ81_RS05490	COG1522	sequence-specific DNA binding
ASZ81_RS05495	COG1946	Acyl-CoA thioesterase
ASZ81_RS05515	COG3706	GGDEF domain
ASZ81_RS05525	COG0640	Transcriptional regulator
ASZ81_RS05530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASZ81_RS05555	COG1881	PFAM PEBP family protein
ASZ81_RS05575	COG0009	L-threonylcarbamoyladenylate synthase
ASZ81_RS05590	COG2201	protein-glutamate methylesterase activity
ASZ81_RS05600	COG5002	protein histidine kinase activity
ASZ81_RS05605	COG4191	Histidine kinase
ASZ81_RS05610	COG3300	MHYT domain
ASZ81_RS05610	COG5001	Diguanylate cyclase
ASZ81_RS05615	COG2204	response regulator
ASZ81_RS05635	COG0601	transmembrane transport
ASZ81_RS05640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASZ81_RS05645	COG0444	Belongs to the ABC transporter superfamily
ASZ81_RS05650	COG4608	Belongs to the ABC transporter superfamily
ASZ81_RS05655	COG0435	Glutathione S-transferase
ASZ81_RS05660	COG0857	belongs to the CobB CobQ family
ASZ81_RS05660	COG0280	phosphate acetyltransferase
ASZ81_RS05665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ASZ81_RS05670	COG3092	negative regulation of chromosome organization
ASZ81_RS05675	COG4628	conserved protein (DUF2132)
ASZ81_RS05685	COG4120	Belongs to the binding-protein-dependent transport system permease family
ASZ81_RS05695	COG2199	diguanylate cyclase activity
ASZ81_RS05695	COG2203	Gaf domain
ASZ81_RS05700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASZ81_RS05710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ASZ81_RS05715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASZ81_RS05720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASZ81_RS05725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASZ81_RS05730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASZ81_RS05735	COG0156	8-amino-7-oxononanoate synthase activity
ASZ81_RS05740	COG2226	methyltransferase
ASZ81_RS05745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ASZ81_RS05755	COG0501	Belongs to the peptidase M48B family
ASZ81_RS05765	COG0300	oxidoreductase activity
ASZ81_RS05780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASZ81_RS05790	COG2268	Band 7 protein
ASZ81_RS05800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASZ81_RS05805	COG2915	High frequency lysogenization protein hflD homolog
ASZ81_RS05810	COG0482	sulfurtransferase activity
ASZ81_RS05815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASZ81_RS05820	COG2916	Histone family protein nucleoid-structuring protein H-NS
ASZ81_RS05825	COG1757	Na H antiporter
ASZ81_RS05830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASZ81_RS05835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASZ81_RS05840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASZ81_RS05845	COG0131	Imidazoleglycerol-phosphate dehydratase
ASZ81_RS05845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASZ81_RS05850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASZ81_RS05855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASZ81_RS05860	COG0107	imidazoleglycerol-phosphate synthase activity
ASZ81_RS05865	COG0140	phosphoribosyl-ATP diphosphatase activity
ASZ81_RS05865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASZ81_RS05870	COG1187	pseudouridine synthase activity
ASZ81_RS05880	COG1278	Cold shock
ASZ81_RS05885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASZ81_RS05890	COG0542	response to heat
ASZ81_RS05895	COG2985	domain, Protein
ASZ81_RS05895	COG3273	potassium ion transport
ASZ81_RS05900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ASZ81_RS05905	COG1012	belongs to the aldehyde dehydrogenase family
ASZ81_RS05905	COG1454	alcohol dehydrogenase
ASZ81_RS05910	COG1737	Transcriptional regulator
ASZ81_RS05915	COG0076	glutamate decarboxylase activity
ASZ81_RS05925	COG2431	L-lysine efflux transmembrane transporter activity
ASZ81_RS05935	COG3070	regulator of competence-specific genes
ASZ81_RS05950	COG3852	Histidine kinase
ASZ81_RS05960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ASZ81_RS05975	COG0189	ligase activity
ASZ81_RS05975	COG4067	protein conserved in archaea
ASZ81_RS05980	COG0500	methyltransferase
ASZ81_RS05985	COG4106	trans-aconitate 2-methyltransferase activity
ASZ81_RS05990	COG1801	Protein of unknown function DUF72
ASZ81_RS05995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASZ81_RS06000	COG1435	thymidine kinase activity
ASZ81_RS06010	COG0159	tryptophan synthase activity
ASZ81_RS06015	COG0133	tryptophan synthase activity
ASZ81_RS06020	COG0134	indole-3-glycerol-phosphate synthase activity
ASZ81_RS06020	COG0135	phosphoribosylanthranilate isomerase activity
ASZ81_RS06025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASZ81_RS06030	COG0512	Glutamine amidotransferase of anthranilate synthase
ASZ81_RS06035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASZ81_RS06045	COG0613	PHP domain protein
ASZ81_RS06050	COG0009	L-threonylcarbamoyladenylate synthase
ASZ81_RS06055	COG1187	pseudouridine synthase activity
ASZ81_RS06060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ASZ81_RS06065	COG4988	ABC transporter
ASZ81_RS06070	COG0492	ferredoxin-NADP+ reductase activity
ASZ81_RS06080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASZ81_RS06085	COG3706	GGDEF domain
ASZ81_RS06090	COG2949	membrane
ASZ81_RS06100	COG0281	malic enzyme
ASZ81_RS06110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASZ81_RS06130	COG2885	chlorophyll binding
ASZ81_RS06145	COG0277	FAD linked oxidase domain protein
ASZ81_RS06145	COG0247	lactate metabolic process
ASZ81_RS06165	COG2986	histidine ammonia-lyase
ASZ81_RS06170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ASZ81_RS06175	COG0010	Belongs to the arginase family
ASZ81_RS06180	COG1228	amidohydrolase
ASZ81_RS06195	COG3099	Belongs to the UPF0263 family
ASZ81_RS06200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASZ81_RS06210	COG5001	Diguanylate cyclase
ASZ81_RS06215	COG0417	DNA replication proofreading
ASZ81_RS06220	COG2197	response regulator
ASZ81_RS06225	COG0322	excinuclease ABC activity
ASZ81_RS06265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASZ81_RS06270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ81_RS06270	COG0072	phenylalanine-tRNA ligase activity
ASZ81_RS06275	COG0776	regulation of translation
ASZ81_RS06315	COG1346	cytolysis
ASZ81_RS06320	COG1380	Effector of murein hydrolase LrgA
ASZ81_RS06325	COG2925	Exonuclease
ASZ81_RS06330	COG1823	symporter activity
ASZ81_RS06335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASZ81_RS06345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASZ81_RS06350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ASZ81_RS06370	COG4139	cobalamin transport
ASZ81_RS06425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASZ81_RS06430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASZ81_RS06435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASZ81_RS06445	COG1054	Belongs to the UPF0176 family
ASZ81_RS06455	COG2814	Major facilitator Superfamily
ASZ81_RS06465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASZ81_RS06490	COG2989	Protein conserved in bacteria
ASZ81_RS06495	COG3108	Peptidase M15
ASZ81_RS06500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASZ81_RS06515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ASZ81_RS06545	COG1846	Transcriptional regulator
ASZ81_RS06550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ASZ81_RS06555	COG0726	polysaccharide deacetylase
ASZ81_RS06560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ASZ81_RS06570	COG1447	Phosphotransferase system cellobiose-specific component IIA
ASZ81_RS06575	COG1486	melibiose metabolic process
ASZ81_RS06585	COG1609	Transcriptional regulator
ASZ81_RS06590	COG2943	transferase activity, transferring hexosyl groups
ASZ81_RS06595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ASZ81_RS06600	COG0840	transmembrane signaling receptor activity
ASZ81_RS06615	COG1448	Aminotransferase
ASZ81_RS06625	COG2770	Histidine kinase
ASZ81_RS06625	COG3437	response regulator, receiver
ASZ81_RS06630	COG0351	phosphomethylpyrimidine kinase
ASZ81_RS06635	COG0017	Asparaginyl-tRNA synthetase
ASZ81_RS06640	COG0840	transmembrane signaling receptor activity
ASZ81_RS06645	COG0720	synthase
ASZ81_RS06650	COG1760	l-serine dehydratase
ASZ81_RS06655	COG0814	amino acid
ASZ81_RS06660	COG0494	nUDIX hydrolase
ASZ81_RS06665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASZ81_RS06680	COG3106	COG3106 Predicted ATPase
ASZ81_RS06685	COG3768	UPF0283 membrane protein
ASZ81_RS06695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASZ81_RS06710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASZ81_RS06720	COG0471	metal ion transport
ASZ81_RS06725	COG4191	Histidine kinase
ASZ81_RS06725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASZ81_RS06735	COG2990	Protein conserved in bacteria
ASZ81_RS06740	COG3713	MltA-interacting MipA family protein
ASZ81_RS06745	COG2205	protein histidine kinase activity
ASZ81_RS06750	COG0745	RESPONSE REGULATOR receiver
ASZ81_RS06785	COG1129	ABC transporter
ASZ81_RS06825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ASZ81_RS06830	COG0372	Belongs to the citrate synthase family
ASZ81_RS06860	COG2195	Cleaves the N-terminal amino acid of tripeptides
ASZ81_RS06870	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ASZ81_RS06880	COG0625	glutathione transferase activity
ASZ81_RS06885	COG3437	response regulator, receiver
ASZ81_RS06905	COG3706	GGDEF domain
ASZ81_RS06910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ASZ81_RS06915	COG1254	Belongs to the acylphosphatase family
ASZ81_RS06920	COG2920	part of a sulfur-relay system
ASZ81_RS06925	COG0670	Belongs to the BI1 family
ASZ81_RS06930	COG1126	abc transporter atp-binding protein
ASZ81_RS06935	COG0765	amino acid transport
ASZ81_RS06940	COG4597	amino acid ABC transporter
ASZ81_RS06945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASZ81_RS06955	COG0561	phosphatase activity
ASZ81_RS06960	COG0602	queuosine metabolic process
ASZ81_RS06965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ASZ81_RS06995	COG3706	GGDEF domain
ASZ81_RS07000	COG0443	Heat shock 70 kDa protein
ASZ81_RS07005	COG0443	Heat shock 70 kDa protein
ASZ81_RS07050	COG1643	Atp-dependent helicase
ASZ81_RS07060	COG0443	Heat shock 70 kDa protein
ASZ81_RS07065	COG0095	Lipoate-protein ligase
ASZ81_RS07075	COG0583	DNA-binding transcription factor activity
ASZ81_RS07080	COG0477	Major facilitator Superfamily
ASZ81_RS07085	COG0415	Belongs to the DNA photolyase family
ASZ81_RS07100	COG0745	RESPONSE REGULATOR receiver
ASZ81_RS07110	COG0643	Histidine kinase
ASZ81_RS07110	COG2198	Histidine kinase
ASZ81_RS07115	COG0643	Histidine kinase
ASZ81_RS07115	COG0784	Response regulator, receiver
ASZ81_RS07115	COG2198	Histidine kinase
ASZ81_RS07120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ASZ81_RS07130	COG2201	protein-glutamate methylesterase activity
ASZ81_RS07135	COG0835	chemotaxis
ASZ81_RS07140	COG3290	protein histidine kinase activity
ASZ81_RS07140	COG0840	transmembrane signaling receptor activity
ASZ81_RS07145	COG0840	transmembrane signaling receptor activity
ASZ81_RS07155	COG0513	Belongs to the DEAD box helicase family
ASZ81_RS07165	COG1538	Outer membrane efflux protein
ASZ81_RS07170	COG1566	PFAM secretion protein HlyD family protein
ASZ81_RS07175	COG2814	Major facilitator Superfamily
ASZ81_RS07185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ASZ81_RS07195	COG3501	Rhs element vgr protein
ASZ81_RS07205	COG3675	Pfam Lipase (class 3)
ASZ81_RS07220	COG1280	lysine exporter protein (LysE YggA)
ASZ81_RS07225	COG1115	amino acid carrier protein
ASZ81_RS07240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ASZ81_RS07250	COG1177	transmembrane transport
ASZ81_RS07260	COG3842	ATPase activity
ASZ81_RS07285	COG0589	response to stress
ASZ81_RS07290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASZ81_RS07305	COG2217	Heavy metal translocating P-type atpase
ASZ81_RS07315	COG2010	Cytochrome c
ASZ81_RS07330	COG3278	Belongs to the heme-copper respiratory oxidase family
ASZ81_RS07345	COG2205	protein histidine kinase activity
ASZ81_RS07345	COG0784	Response regulator, receiver
ASZ81_RS07370	COG2994	toxin metabolic process
ASZ81_RS07375	COG3064	Membrane
ASZ81_RS07375	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ASZ81_RS07375	COG1073	alpha beta
ASZ81_RS07390	COG4128	Pfam Zonular occludens toxin
ASZ81_RS07420	COG1476	TRANSCRIPTIONal
ASZ81_RS07445	COG1476	TRANSCRIPTIONal
ASZ81_RS07550	COG3120	sequence-specific DNA binding
ASZ81_RS07555	COG1067	ATP-dependent peptidase activity
ASZ81_RS07560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASZ81_RS07575	COG0488	(ABC) transporter
ASZ81_RS07585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ASZ81_RS07585	COG0116	Belongs to the methyltransferase superfamily
ASZ81_RS07595	COG0167	dihydroorotate dehydrogenase activity
ASZ81_RS07610	COG0308	aminopeptidase N
ASZ81_RS07625	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ASZ81_RS07630	COG1956	GAF domain-containing protein
ASZ81_RS07635	COG1132	(ABC) transporter
ASZ81_RS07640	COG2995	paraquat-inducible protein a
ASZ81_RS07645	COG3008	intermembrane lipid transfer
ASZ81_RS07655	COG2996	Protein conserved in bacteria
ASZ81_RS07670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASZ81_RS07675	COG1666	GTP binding
ASZ81_RS07680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASZ81_RS07695	COG0437	4 iron, 4 sulfur cluster binding
ASZ81_RS07700	COG0243	molybdopterin cofactor binding
ASZ81_RS07700	COG3383	formate dehydrogenase (NAD+) activity
ASZ81_RS07730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASZ81_RS07735	COG0488	(ABC) transporter
ASZ81_RS07740	COG3852	Histidine kinase
ASZ81_RS07745	COG2204	response regulator
ASZ81_RS07755	COG4662	Binding-protein-dependent transport system inner membrane component
ASZ81_RS07760	COG3842	ATPase activity
ASZ81_RS07765	COG0746	molybdenum cofactor guanylyltransferase activity
ASZ81_RS07800	COG1940	carbohydrate kinase activity
ASZ81_RS07805	COG3148	PFAM DTW domain containing protein
ASZ81_RS07815	COG0840	transmembrane signaling receptor activity
ASZ81_RS07820	COG0791	NLP P60 protein
ASZ81_RS07830	COG3001	Fructosamine kinase
ASZ81_RS07840	COG0534	Mate efflux family protein
ASZ81_RS07850	COG1793	dna ligase
ASZ81_RS07865	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ASZ81_RS07870	COG0848	biopolymer transport protein
ASZ81_RS07875	COG0811	peptide transport
ASZ81_RS07880	COG0811	peptide transport
ASZ81_RS07895	COG1175	transmembrane transport
ASZ81_RS07900	COG0395	ABC-type sugar transport system, permease component
ASZ81_RS07905	COG3842	ATPase activity
ASZ81_RS07910	COG1349	DNA-binding transcription factor activity
ASZ81_RS07915	COG0584	glycerophosphoryl diester phosphodiesterase
ASZ81_RS07920	COG2731	YhcH YjgK YiaL family protein
ASZ81_RS07925	COG0251	oxidation-reduction process
ASZ81_RS07930	COG1609	Transcriptional regulator
ASZ81_RS07935	COG2723	6-phospho-beta-galactosidase activity
ASZ81_RS07945	COG0583	DNA-binding transcription factor activity
ASZ81_RS07965	COG1136	(ABC) transporter
ASZ81_RS07965	COG0577	efflux transmembrane transporter activity
ASZ81_RS07970	COG0577	efflux transmembrane transporter activity
ASZ81_RS07970	COG1136	(ABC) transporter
ASZ81_RS07975	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASZ81_RS07975	COG1136	(ABC) transporter
ASZ81_RS07980	COG1294	oxidase, subunit
ASZ81_RS07985	COG1271	oxidase subunit
ASZ81_RS08030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASZ81_RS08040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASZ81_RS08060	COG0753	catalase activity
ASZ81_RS08075	COG3527	Alpha-acetolactate decarboxylase
ASZ81_RS08090	COG2200	EAL domain
ASZ81_RS08090	COG2199	diguanylate cyclase activity
ASZ81_RS08100	COG2017	converts alpha-aldose to the beta-anomer
ASZ81_RS08105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASZ81_RS08110	COG1085	galactose-1-phosphate uridylyltransferase
ASZ81_RS08155	COG0784	Response regulator, receiver
ASZ81_RS08155	COG0835	chemotaxis
ASZ81_RS08165	COG4565	transcriptional regulatory protein
ASZ81_RS08170	COG3290	protein histidine kinase activity
ASZ81_RS08185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ81_RS08205	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ASZ81_RS08210	COG3063	Type IV pilus biogenesis stability protein PilW
ASZ81_RS08225	COG1451	nucleotide metabolic process
ASZ81_RS08235	COG0583	DNA-binding transcription factor activity
ASZ81_RS08265	COG1538	Outer membrane efflux protein
ASZ81_RS08280	COG1748	Saccharopine dehydrogenase
ASZ81_RS08295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASZ81_RS08305	COG0577	efflux transmembrane transporter activity
ASZ81_RS08310	COG4181	ATPase activity
ASZ81_RS08315	COG0534	Mate efflux family protein
ASZ81_RS08320	COG0702	epimerase
ASZ81_RS08330	COG2814	Major facilitator Superfamily
ASZ81_RS08335	COG1187	pseudouridine synthase activity
ASZ81_RS08340	COG1061	Type III restriction enzyme res subunit
ASZ81_RS08360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASZ81_RS08365	COG5001	Diguanylate cyclase
ASZ81_RS08365	COG3706	GGDEF domain
ASZ81_RS08365	COG2203	Gaf domain
ASZ81_RS08365	COG4251	negative regulation of phosphorylation
ASZ81_RS08380	COG0840	transmembrane signaling receptor activity
ASZ81_RS08410	COG4934	collagen metabolic process
ASZ81_RS08425	COG0784	Response regulator, receiver
ASZ81_RS08425	COG2205	protein histidine kinase activity
ASZ81_RS08430	COG2239	Acts as a magnesium transporter
ASZ81_RS08440	COG0814	amino acid
ASZ81_RS08445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ81_RS08450	COG1131	(ABC) transporter
ASZ81_RS08455	COG0842	Transport permease protein
ASZ81_RS08465	COG3313	Fe-S protein
ASZ81_RS08475	COG4134	Bacterial extracellular solute-binding protein
ASZ81_RS08480	COG4135	transport system, permease component
ASZ81_RS08485	COG4136	ATPase activity
ASZ81_RS08490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASZ81_RS08495	COG0564	pseudouridine synthase activity
ASZ81_RS08500	COG0733	neurotransmitter:sodium symporter activity
ASZ81_RS08515	COG0626	cystathionine gamma-synthase activity
ASZ81_RS08520	COG2818	Glycosylase
ASZ81_RS08535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ81_RS08550	COG1842	Phage shock protein A
ASZ81_RS08555	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ASZ81_RS08565	COG4168	peptide transport system, permease
ASZ81_RS08580	COG4172	Belongs to the ABC transporter superfamily
ASZ81_RS08595	COG1227	inorganic diphosphatase activity
ASZ81_RS08615	COG0243	molybdopterin cofactor binding
ASZ81_RS08620	COG3005	denitrification pathway
ASZ81_RS08625	COG4459	periplasmic nitrate reductase
ASZ81_RS08635	COG2116	formate transmembrane transporter activity
ASZ81_RS08650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASZ81_RS08655	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ASZ81_RS08670	COG1607	acyl-coa hydrolase
ASZ81_RS08675	COG2350	Protein conserved in bacteria
ASZ81_RS08685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASZ81_RS08690	COG0583	DNA-binding transcription factor activity
ASZ81_RS08705	COG0612	Peptidase, M16
ASZ81_RS08710	COG5001	Diguanylate cyclase
ASZ81_RS08715	COG1032	radical SAM domain protein
ASZ81_RS08735	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ASZ81_RS08745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASZ81_RS08750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ASZ81_RS08755	COG0745	RESPONSE REGULATOR receiver
ASZ81_RS08760	COG3381	protein complex oligomerization
ASZ81_RS08770	COG1609	Transcriptional regulator
ASZ81_RS08775	COG3070	regulator of competence-specific genes
ASZ81_RS08795	COG0297	glycogen (starch) synthase activity
ASZ81_RS08800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASZ81_RS08805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASZ81_RS08835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASZ81_RS08845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ASZ81_RS08870	COG1012	belongs to the aldehyde dehydrogenase family
ASZ81_RS08875	COG1309	transcriptional regulator
ASZ81_RS08900	COG0668	transmembrane transport
ASZ81_RS08905	COG2995	paraquat-inducible protein a
ASZ81_RS08910	COG3008	intermembrane lipid transfer
ASZ81_RS08910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ASZ81_RS08920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ81_RS08935	COG0582	viral genome integration into host DNA
ASZ81_RS08945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASZ81_RS08965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASZ81_RS08985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASZ81_RS09005	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
ASZ81_RS09010	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
ASZ81_RS09015	COG1737	Transcriptional regulator
ASZ81_RS09020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASZ81_RS09025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ASZ81_RS09030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ASZ81_RS09035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ASZ81_RS09050	COG1940	carbohydrate kinase activity
ASZ81_RS09055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASZ81_RS09060	COG4409	exo-alpha-(2->6)-sialidase activity
ASZ81_RS09070	COG2003	Belongs to the UPF0758 family
ASZ81_RS09090	COG3941	tape measure
ASZ81_RS09135	COG0488	(ABC) transporter
ASZ81_RS09220	COG0415	Belongs to the DNA photolyase family
ASZ81_RS09230	COG4628	conserved protein (DUF2132)
ASZ81_RS09235	COG3284	Transcriptional regulator
ASZ81_RS09240	COG1012	belongs to the aldehyde dehydrogenase family
ASZ81_RS09250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ81_RS09255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ81_RS09260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ81_RS09270	COG2207	Transcriptional regulator
ASZ81_RS09275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ81_RS09275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ81_RS09275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ81_RS09280	COG1482	cell wall glycoprotein biosynthetic process
ASZ81_RS09290	COG5002	protein histidine kinase activity
ASZ81_RS09290	COG0784	Response regulator, receiver
ASZ81_RS09300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ASZ81_RS09310	COG2885	chlorophyll binding
ASZ81_RS09315	COG0823	Involved in the tonB-independent uptake of proteins
ASZ81_RS09330	COG0811	peptide transport
ASZ81_RS09335	COG0824	Thioesterase
ASZ81_RS09340	COG3790	cyd operon protein YbgE
ASZ81_RS09345	COG4890	Cyd operon protein YbgT
ASZ81_RS09350	COG1294	oxidase, subunit
ASZ81_RS09355	COG1271	oxidase subunit
ASZ81_RS09365	COG0632	four-way junction helicase activity
ASZ81_RS09370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASZ81_RS09375	COG0215	cysteine-tRNA ligase activity
ASZ81_RS09380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASZ81_RS09385	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ81_RS09390	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ASZ81_RS09395	COG3012	SEC-C Motif Domain Protein
ASZ81_RS09400	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ASZ81_RS09405	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ASZ81_RS09410	COG1199	ATP-dependent helicase activity
ASZ81_RS09415	COG0730	response to heat
ASZ81_RS09420	COG3923	Primosomal replication protein n
ASZ81_RS09430	COG0840	transmembrane signaling receptor activity
ASZ81_RS09435	COG0708	Exodeoxyribonuclease III
ASZ81_RS09440	COG4160	amino acid transport
ASZ81_RS09465	COG1882	Formate acetyltransferase
ASZ81_RS09475	COG0840	transmembrane signaling receptor activity
ASZ81_RS09480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ASZ81_RS09490	COG3013	Belongs to the UPF0304 family
ASZ81_RS09495	COG2766	serine protein kinase
ASZ81_RS09500	COG2718	Belongs to the UPF0229 family
ASZ81_RS09505	COG2719	SpoVR family
ASZ81_RS09510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ASZ81_RS09515	COG2835	tetraacyldisaccharide 4'-kinase activity
ASZ81_RS09520	COG1663	tetraacyldisaccharide 4'-kinase activity
ASZ81_RS09525	COG1132	(ABC) transporter
ASZ81_RS09530	COG0658	competence protein
ASZ81_RS09530	COG2333	competence protein COMEC
ASZ81_RS09540	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASZ81_RS09545	COG1136	(ABC) transporter
ASZ81_RS09550	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASZ81_RS09560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ASZ81_RS09580	COG1252	NADH dehydrogenase
ASZ81_RS09585	COG3150	esterase
ASZ81_RS09610	COG0537	adenosine 5'-monophosphoramidase activity
ASZ81_RS09625	COG2186	Transcriptional regulator
ASZ81_RS09630	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASZ81_RS09635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ASZ81_RS09640	COG1674	ftsk spoiiie
ASZ81_RS09650	COG0686	Belongs to the AlaDH PNT family
ASZ81_RS09660	COG0583	DNA-binding transcription factor activity
ASZ81_RS09680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ASZ81_RS09685	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ASZ81_RS09690	COG0776	regulation of translation
ASZ81_RS09695	COG0539	negative regulation of cytoplasmic translation
ASZ81_RS09700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASZ81_RS09705	COG1555	photosystem II stabilization
ASZ81_RS09710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASZ81_RS09715	COG0776	regulation of translation
ASZ81_RS09720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ASZ81_RS09725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASZ81_RS09735	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASZ81_RS09745	COG4191	Histidine kinase
ASZ81_RS09755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ASZ81_RS09760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ASZ81_RS09765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ASZ81_RS09770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ASZ81_RS09785	COG3300	MHYT domain
ASZ81_RS09785	COG5001	Diguanylate cyclase
ASZ81_RS09795	COG4589	Belongs to the CDS family
ASZ81_RS09835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASZ81_RS09845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ81_RS09860	COG0243	molybdopterin cofactor binding
ASZ81_RS09865	COG3005	denitrification pathway
ASZ81_RS09870	COG3325	Belongs to the glycosyl hydrolase 18 family
ASZ81_RS09870	COG3469	chitinase activity
ASZ81_RS09875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASZ81_RS09885	COG2951	lytic endotransglycosylase activity
ASZ81_RS09890	COG3100	YcgL domain-containing protein
ASZ81_RS09895	COG0850	regulation of cytokinetic process
ASZ81_RS09900	COG2894	cell division
ASZ81_RS09905	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ASZ81_RS09910	COG3015	lipoprotein NlpE involved in copper resistance
ASZ81_RS09930	COG0477	Major facilitator Superfamily
ASZ81_RS09940	COG0840	transmembrane signaling receptor activity
ASZ81_RS09945	COG1396	sequence-specific DNA binding
ASZ81_RS09950	COG3135	benzoate transporter
ASZ81_RS09970	COG0596	Alpha beta hydrolase
ASZ81_RS09975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ASZ81_RS09980	COG1169	isochorismate synthase
ASZ81_RS09985	COG0436	Aminotransferase
ASZ81_RS09990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ASZ81_RS09995	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ASZ81_RS10015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ASZ81_RS10020	COG0318	PFAM AMP-dependent synthetase and ligase
ASZ81_RS10025	COG0596	Alpha beta hydrolase
ASZ81_RS10040	COG1214	PFAM Peptidase M22, glycoprotease
ASZ81_RS10045	COG1199	ATP-dependent helicase activity
ASZ81_RS10055	COG0788	formyltetrahydrofolate deformylase activity
ASZ81_RS10060	COG1902	pentaerythritol trinitrate reductase activity
ASZ81_RS10060	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASZ81_RS10065	COG0616	signal peptide processing
ASZ81_RS10070	COG0252	asparaginase activity
ASZ81_RS10075	COG3139	Protein of unknown function (DUF1315)
ASZ81_RS10085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASZ81_RS10090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASZ81_RS10095	COG0676	glucose-6-phosphate 1-epimerase activity
ASZ81_RS10115	COG2226	methyltransferase
ASZ81_RS10130	COG0784	Response regulator, receiver
ASZ81_RS10130	COG0835	chemotaxis
ASZ81_RS10135	COG1940	carbohydrate kinase activity
ASZ81_RS10145	COG4667	esterase of the alpha-beta hydrolase superfamily
ASZ81_RS10155	COG0733	neurotransmitter:sodium symporter activity
ASZ81_RS10160	COG1263	PTS System
ASZ81_RS10160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ81_RS10165	COG0084	hydrolase, TatD family'
ASZ81_RS10175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASZ81_RS10180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ASZ81_RS10185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASZ81_RS10190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASZ81_RS10195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASZ81_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
ASZ81_RS10210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASZ81_RS10215	COG0416	fatty acid biosynthetic process
ASZ81_RS10220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASZ81_RS10225	COG1399	metal-binding, possibly nucleic acid-binding protein
ASZ81_RS10230	COG0424	maF-like protein
ASZ81_RS10235	COG0564	pseudouridine synthase activity
ASZ81_RS10250	COG1530	ribonuclease E activity
ASZ81_RS10255	COG0659	secondary active sulfate transmembrane transporter activity
ASZ81_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
ASZ81_RS10270	COG1454	alcohol dehydrogenase
ASZ81_RS10275	COG2095	MarC family integral membrane protein
ASZ81_RS10280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASZ81_RS10285	COG1757	Na H antiporter
ASZ81_RS10295	COG3081	Nucleoid-associated protein
ASZ81_RS10300	COG3082	Protein of unknown function (DUF1414)
ASZ81_RS10305	COG3083	sulfuric ester hydrolase activity
ASZ81_RS10320	COG0123	including yeast histone deacetylase and acetoin utilization protein
ASZ81_RS10325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASZ81_RS10330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ASZ81_RS10350	COG2853	Lipoprotein
ASZ81_RS10360	COG3088	subunit of a heme lyase
ASZ81_RS10360	COG4235	cytochrome complex assembly
ASZ81_RS10365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASZ81_RS10370	COG1138	Cytochrome C-type biogenesis protein
ASZ81_RS10375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ASZ81_RS10385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASZ81_RS10390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASZ81_RS10395	COG4133	protoheme IX ABC transporter activity
ASZ81_RS10405	COG0835	chemotaxis
ASZ81_RS10420	COG2198	Histidine kinase
ASZ81_RS10420	COG0784	Response regulator, receiver
ASZ81_RS10420	COG0643	Histidine kinase
ASZ81_RS10425	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ASZ81_RS10455	COG2062	phosphohistidine phosphatase, SixA
ASZ81_RS10460	COG1025	Belongs to the peptidase M16 family
ASZ81_RS10470	COG0018	arginyl-trna synthetase
ASZ81_RS10490	COG1918	ferrous iron import across plasma membrane
ASZ81_RS10495	COG4977	sequence-specific DNA binding
ASZ81_RS10500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ASZ81_RS10505	COG1121	(ABC) transporter
ASZ81_RS10510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASZ81_RS10520	COG0045	succinate-CoA ligase (ADP-forming) activity
ASZ81_RS10525	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASZ81_RS10530	COG0567	Dehydrogenase, E1 component
ASZ81_RS10540	COG1053	succinate dehydrogenase
ASZ81_RS10545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ASZ81_RS10550	COG2009	succinate dehydrogenase
ASZ81_RS10555	COG0372	Belongs to the citrate synthase family
ASZ81_RS10560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASZ81_RS10570	COG0033	Phosphoglucomutase
ASZ81_RS10575	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ASZ81_RS10580	COG0596	Alpha beta hydrolase
ASZ81_RS10595	COG1346	cytolysis
ASZ81_RS10605	COG0583	DNA-binding transcription factor activity
ASZ81_RS10615	COG0735	belongs to the Fur family
ASZ81_RS10620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASZ81_RS10625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASZ81_RS10630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASZ81_RS10640	COG0431	NADPH-dependent FMN reductase
ASZ81_RS10650	COG3101	peptidyl-lysine hydroxylation
ASZ81_RS10655	COG2860	membrane
ASZ81_RS10660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASZ81_RS10670	COG2890	protein-(glutamine-N5) methyltransferase activity
ASZ81_RS10675	COG2840	Smr protein MutS2
ASZ81_RS10685	COG1684	flagellar biosynthetic protein fliR
ASZ81_RS10690	COG1987	bacterial-type flagellum assembly
ASZ81_RS10715	COG1580	Controls the rotational direction of flagella during chemotaxis
ASZ81_RS10740	COG1317	bacterial-type flagellum organization
ASZ81_RS10745	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASZ81_RS10755	COG1677	Flagellar hook-basal body complex protein FliE
ASZ81_RS10775	COG1516	flagellar protein fliS
ASZ81_RS10785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ASZ81_RS10790	COG1334	flagellar protein FlaG
ASZ81_RS10795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ81_RS10800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ81_RS10805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ81_RS10810	COG2837	iron assimilation
ASZ81_RS10830	COG1393	Belongs to the ArsC family
ASZ81_RS10840	COG1876	peptidase activity
ASZ81_RS10850	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ASZ81_RS10865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASZ81_RS10885	COG4783	chaperone-mediated protein folding
ASZ81_RS10890	COG1393	Belongs to the ArsC family
ASZ81_RS10910	COG2233	PERMEase
ASZ81_RS10915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASZ81_RS10920	COG0737	Belongs to the 5'-nucleotidase family
ASZ81_RS10925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ASZ81_RS10930	COG2912	Transglutaminase-like superfamily
ASZ81_RS10940	COG2890	protein-(glutamine-N5) methyltransferase activity
ASZ81_RS10945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASZ81_RS10950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASZ81_RS10955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ASZ81_RS10960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASZ81_RS10965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASZ81_RS10970	COG0193	aminoacyl-tRNA hydrolase activity
ASZ81_RS10975	COG0012	GTP binding
ASZ81_RS11060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ81_RS11185	COG4695	Portal protein
ASZ81_RS11285	COG4974	Belongs to the 'phage' integrase family
ASZ81_RS11290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ81_RS11305	COG1705	Flagellar rod assembly protein muramidase FlgJ
ASZ81_RS11305	COG3951	Flagellar rod assembly protein muramidase FlgJ
ASZ81_RS11310	COG1706	bacterial-type flagellum-dependent cell motility
ASZ81_RS11315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ASZ81_RS11325	COG4787	bacterial-type flagellum-dependent cell motility
ASZ81_RS11330	COG1749	Flagellar hook protein flgE
ASZ81_RS11345	COG1815	bacterial-type flagellum-dependent cell motility
ASZ81_RS11350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ASZ81_RS11355	COG0784	Response regulator, receiver
ASZ81_RS11355	COG0835	chemotaxis
ASZ81_RS11390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASZ81_RS11390	COG2226	methyltransferase
ASZ81_RS11390	COG3433	isochorismatase activity
ASZ81_RS11395	COG2375	cellular response to nickel ion
ASZ81_RS11400	COG1629	transport
ASZ81_RS11400	COG4774	siderophore transport
ASZ81_RS11420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASZ81_RS11425	COG2217	Heavy metal translocating P-type atpase
ASZ81_RS11425	COG2608	mercury ion transmembrane transporter activity
ASZ81_RS11440	COG3735	TraB family
ASZ81_RS11455	COG2840	Smr protein MutS2
ASZ81_RS11460	COG1187	pseudouridine synthase activity
ASZ81_RS11470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASZ81_RS11475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASZ81_RS11480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ASZ81_RS11485	COG0121	glutamine amidotransferase
ASZ81_RS11490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASZ81_RS11495	COG1960	acyl-CoA dehydrogenase activity
ASZ81_RS11510	COG0328	RNA-DNA hybrid ribonuclease activity
ASZ81_RS11515	COG2226	methyltransferase
ASZ81_RS11520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASZ81_RS11525	COG0741	lytic transglycosylase activity
ASZ81_RS11525	COG1388	LysM domain
ASZ81_RS11530	COG3021	interspecies interaction between organisms
ASZ81_RS11535	COG0347	Belongs to the P(II) protein family
ASZ81_RS11540	COG3479	Phenolic acid decarboxylase
ASZ81_RS11550	COG0037	tRNA processing
ASZ81_RS11555	COG0825	malonyl-CoA metabolic process
ASZ81_RS11560	COG0587	DNA-directed DNA polymerase activity
ASZ81_RS11565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASZ81_RS11570	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ81_RS11575	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ81_RS11580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASZ81_RS11585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ81_RS11590	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ASZ81_RS11600	COG0750	zinc metalloprotease
ASZ81_RS11605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASZ81_RS11610	COG0575	Belongs to the CDS family
ASZ81_RS11615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASZ81_RS11620	COG0233	cytoplasmic translational termination
ASZ81_RS11625	COG0528	UMP kinase activity
ASZ81_RS11630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASZ81_RS11635	COG0052	Belongs to the universal ribosomal protein uS2 family
ASZ81_RS11640	COG0024	Methionine aminopeptidase
ASZ81_RS11645	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ASZ81_RS11660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ASZ81_RS11665	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ASZ81_RS11670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASZ81_RS11675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASZ81_RS11690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASZ81_RS11690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASZ81_RS11695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASZ81_RS11700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASZ81_RS11705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASZ81_RS11715	COG1073	alpha beta
ASZ81_RS11720	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASZ81_RS11725	COG2252	PERMEase
ASZ81_RS11730	COG2195	Cleaves the N-terminal amino acid of tripeptides
ASZ81_RS11735	COG0189	ligase activity
ASZ81_RS11735	COG4067	protein conserved in archaea
ASZ81_RS11740	COG0189	ligase activity
ASZ81_RS11750	COG0733	neurotransmitter:sodium symporter activity
ASZ81_RS11755	COG3706	GGDEF domain
ASZ81_RS11775	COG1477	protein flavinylation
ASZ81_RS11780	COG2871	sodium ion transport
ASZ81_RS11785	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ81_RS11790	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ81_RS11795	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ81_RS11800	COG1805	sodium ion transport
ASZ81_RS11805	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ81_RS11810	COG0271	Belongs to the BolA IbaG family
ASZ81_RS11815	COG2813	Specifically methylates the guanine in position
ASZ81_RS11825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASZ81_RS11830	COG2211	Major facilitator Superfamily
ASZ81_RS11840	COG1595	DNA-templated transcription, initiation
ASZ81_RS11850	COG3248	Nucleoside-binding outer membrane protein
ASZ81_RS11855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASZ81_RS11860	COG0693	protein deglycase activity
ASZ81_RS11865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASZ81_RS11870	COG2166	iron-sulfur cluster assembly
ASZ81_RS11875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ASZ81_RS11880	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ASZ81_RS11890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ASZ81_RS11890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASZ81_RS11905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASZ81_RS11910	COG1074	ATP-dependent DNA helicase activity
ASZ81_RS11915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ASZ81_RS11930	COG3141	response to X-ray
ASZ81_RS11935	COG2171	N-acyltransferase activity
ASZ81_RS11945	COG0456	acetyltransferase
ASZ81_RS11950	COG0189	ligase activity
ASZ81_RS11950	COG0569	domain protein
ASZ81_RS11965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ81_RS11970	COG1609	Transcriptional regulator
ASZ81_RS11975	COG3250	beta-galactosidase activity
ASZ81_RS11990	COG1022	Amp-dependent synthetase and ligase
ASZ81_RS11995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ81_RS12000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ASZ81_RS12015	COG0560	Phosphoserine phosphatase
ASZ81_RS12025	COG0813	purine-nucleoside phosphorylase activity
ASZ81_RS12030	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ASZ81_RS12035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ASZ81_RS12040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASZ81_RS12050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASZ81_RS12055	COG0084	hydrolase, TatD family'
ASZ81_RS12060	COG3022	response to hydroperoxide
ASZ81_RS12065	COG1115	amino acid carrier protein
ASZ81_RS12080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASZ81_RS12085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ASZ81_RS12090	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ASZ81_RS12095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASZ81_RS12120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ASZ81_RS12130	COG0745	RESPONSE REGULATOR receiver
ASZ81_RS12135	COG0784	Response regulator, receiver
ASZ81_RS12135	COG2198	Histidine kinase
ASZ81_RS12135	COG5002	protein histidine kinase activity
ASZ81_RS12140	COG5001	Diguanylate cyclase
ASZ81_RS12140	COG4251	negative regulation of phosphorylation
ASZ81_RS12140	COG2203	Gaf domain
ASZ81_RS12140	COG3706	GGDEF domain
ASZ81_RS12145	COG1242	4 iron, 4 sulfur cluster binding
ASZ81_RS12150	COG0070	glutamate synthase
ASZ81_RS12150	COG0069	glutamate synthase activity
ASZ81_RS12150	COG0067	glutamate synthase
ASZ81_RS12160	COG0067	glutamate synthase
ASZ81_RS12160	COG0069	glutamate synthase activity
ASZ81_RS12160	COG0070	glutamate synthase
ASZ81_RS12165	COG0493	'glutamate synthase
ASZ81_RS12175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASZ81_RS12185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASZ81_RS12190	COG2860	membrane
ASZ81_RS12195	COG0583	DNA-binding transcription factor activity
ASZ81_RS12200	COG0730	response to heat
ASZ81_RS12210	COG4172	Belongs to the ABC transporter superfamily
ASZ81_RS12235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASZ81_RS12240	COG0505	Belongs to the CarA family
ASZ81_RS12250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASZ81_RS12255	COG0494	nUDIX hydrolase
ASZ81_RS12265	COG0653	protein targeting
ASZ81_RS12275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ASZ81_RS12280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASZ81_RS12285	COG0849	cell division
ASZ81_RS12290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ASZ81_RS12295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASZ81_RS12305	COG0772	Belongs to the SEDS family
ASZ81_RS12310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASZ81_RS12320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASZ81_RS12325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ASZ81_RS12330	COG0768	penicillin binding
ASZ81_RS12335	COG3116	cell division
ASZ81_RS12350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ81_RS12355	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASZ81_RS12360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASZ81_RS12365	COG2186	Transcriptional regulator
ASZ81_RS12375	COG0737	Belongs to the 5'-nucleotidase family
ASZ81_RS12380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ASZ81_RS12385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASZ81_RS12390	COG4974	Belongs to the 'phage' integrase family
ASZ81_RS12395	COG0716	FMN binding
ASZ81_RS12415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASZ81_RS12420	COG1459	type II secretion system
ASZ81_RS12430	COG0237	dephospho-CoA kinase activity
ASZ81_RS12435	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ASZ81_RS12445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASZ81_RS12450	COG0187	DNA topoisomerase II activity
ASZ81_RS12455	COG3150	esterase
ASZ81_RS12465	COG3151	Protein conserved in bacteria
ASZ81_RS12470	COG0494	nUDIX hydrolase
ASZ81_RS12475	COG1538	Outer membrane efflux protein
ASZ81_RS12485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASZ81_RS12490	COG0840	transmembrane signaling receptor activity
ASZ81_RS12495	COG3025	triphosphatase activity
ASZ81_RS12500	COG1392	Phosphate transport regulator
ASZ81_RS12505	COG0306	phosphate transporter
ASZ81_RS12510	COG4991	sh3 domain protein
ASZ81_RS12520	COG3409	Peptidoglycan-binding domain 1 protein
ASZ81_RS12520	COG3267	Type II secretory pathway component ExeA
ASZ81_RS12530	COG0148	phosphopyruvate hydratase activity
ASZ81_RS12535	COG0504	CTP synthase activity
ASZ81_RS12540	COG3956	TIGRFAM MazG family protein
ASZ81_RS12545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASZ81_RS12560	COG5001	Diguanylate cyclase
ASZ81_RS12580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ASZ81_RS12585	COG1381	Involved in DNA repair and RecF pathway recombination
ASZ81_RS12590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASZ81_RS12605	COG0481	GTPase activity
ASZ81_RS12610	COG3086	response to oxidative stress
ASZ81_RS12625	COG1595	DNA-templated transcription, initiation
ASZ81_RS12635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASZ81_RS12645	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ASZ81_RS12660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ81_RS12665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ81_RS12670	COG3079	Belongs to the UPF0149 family
ASZ81_RS12675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ASZ81_RS12685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ASZ81_RS12690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ASZ81_RS12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASZ81_RS12700	COG0440	acetolactate synthase activity
ASZ81_RS12705	COG0028	Belongs to the TPP enzyme family
ASZ81_RS12710	COG1022	Amp-dependent synthetase and ligase
ASZ81_RS12715	COG0583	DNA-binding transcription factor activity
ASZ81_RS12740	COG0473	3-isopropylmalate dehydrogenase activity
ASZ81_RS12745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASZ81_RS12750	COG0066	3-isopropylmalate dehydratase activity
ASZ81_RS12795	COG3437	response regulator, receiver
ASZ81_RS12810	COG0795	lipopolysaccharide-transporting ATPase activity
ASZ81_RS12815	COG0795	lipopolysaccharide-transporting ATPase activity
ASZ81_RS12820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASZ81_RS12825	COG2927	DNA polymerase III (CHI subunit)
ASZ81_RS12830	COG0525	valine-tRNA ligase activity
ASZ81_RS12835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASZ81_RS12840	COG0564	pseudouridine synthase activity
ASZ81_RS12855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASZ81_RS12865	COG0540	Belongs to the ATCase OTCase family
ASZ81_RS12875	COG0251	oxidation-reduction process
ASZ81_RS12885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASZ81_RS12890	COG5007	Belongs to the BolA IbaG family
ASZ81_RS12900	COG2854	intermembrane phospholipid transfer
ASZ81_RS12905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ASZ81_RS12910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ASZ81_RS12915	COG1127	ABC transporter
ASZ81_RS12930	COG0517	IMP dehydrogenase activity
ASZ81_RS12930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASZ81_RS12945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ASZ81_RS12950	COG1137	ATPase activity
ASZ81_RS12960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASZ81_RS12965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ81_RS12970	COG1660	Displays ATPase and GTPase activities
ASZ81_RS12975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ81_RS12980	COG2239	Acts as a magnesium transporter
ASZ81_RS12985	COG0312	modulator of DNA gyrase
ASZ81_RS12990	COG3028	Belongs to the UPF0307 family
ASZ81_RS12995	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ASZ81_RS13000	COG1178	ABC-type Fe3 transport system permease component
ASZ81_RS13010	COG0163	prenyltransferase activity
ASZ81_RS13015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASZ81_RS13030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ASZ81_RS13035	COG2105	PFAM AIG2 family protein
ASZ81_RS13045	COG0729	surface antigen
ASZ81_RS13050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASZ81_RS13055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ASZ81_RS13070	COG1136	(ABC) transporter
ASZ81_RS13090	COG0529	Catalyzes the synthesis of activated sulfate
ASZ81_RS13105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASZ81_RS13105	COG1648	precorrin-2 dehydrogenase activity
ASZ81_RS13110	COG0737	Belongs to the 5'-nucleotidase family
ASZ81_RS13120	COG0513	Belongs to the DEAD box helicase family
ASZ81_RS13125	COG2153	protein acetylation
ASZ81_RS13130	COG0697	spore germination
ASZ81_RS13135	COG3061	Opacity-associated protein A
ASZ81_RS13135	COG3266	domain, Protein
ASZ81_RS13140	COG0545	Peptidyl-prolyl cis-trans isomerase
ASZ81_RS13150	COG0203	ribosomal protein L17
ASZ81_RS13155	COG0202	RNA polymerase activity
ASZ81_RS13160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASZ81_RS13165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASZ81_RS13170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASZ81_RS13175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASZ81_RS13180	COG0201	protein transport
ASZ81_RS13190	COG1841	ribosomal large subunit assembly
ASZ81_RS13195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASZ81_RS13200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASZ81_RS13210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASZ81_RS13215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASZ81_RS13220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASZ81_RS13225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASZ81_RS13230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASZ81_RS13235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASZ81_RS13240	COG0255	Belongs to the universal ribosomal protein uL29 family
ASZ81_RS13245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASZ81_RS13250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASZ81_RS13255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASZ81_RS13260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASZ81_RS13265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASZ81_RS13270	COG0089	rRNA binding
ASZ81_RS13275	COG0088	Forms part of the polypeptide exit tunnel
ASZ81_RS13280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASZ81_RS13285	COG0051	transcription antitermination factor activity, RNA binding
ASZ81_RS13290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASZ81_RS13295	COG0557	exoribonuclease II activity
ASZ81_RS13300	COG3083	sulfuric ester hydrolase activity
ASZ81_RS13305	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ASZ81_RS13325	COG1047	Peptidyl-prolyl cis-trans
ASZ81_RS13340	COG2249	NAD(P)H dehydrogenase (quinone) activity
ASZ81_RS13345	COG0488	(ABC) transporter
ASZ81_RS13355	COG0429	hydrolase of the alpha beta-hydrolase fold
ASZ81_RS13365	COG3954	Phosphoribulokinase
ASZ81_RS13380	COG1012	belongs to the aldehyde dehydrogenase family
ASZ81_RS13390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASZ81_RS13400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASZ81_RS13415	COG0180	Tryptophanyl-tRNA synthetase
ASZ81_RS13420	COG0546	phosphoglycolate phosphatase activity
ASZ81_RS13425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASZ81_RS13430	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ASZ81_RS13440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASZ81_RS13445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASZ81_RS13475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ASZ81_RS13485	COG0678	peroxiredoxin activity
ASZ81_RS13485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ASZ81_RS13490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ81_RS13500	COG0165	Argininosuccinate lyase
ASZ81_RS13510	COG0137	argininosuccinate synthase activity
ASZ81_RS13515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASZ81_RS13520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASZ81_RS13525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASZ81_RS13530	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ASZ81_RS13540	COG1045	serine acetyltransferase
ASZ81_RS13545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASZ81_RS13550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ASZ81_RS13555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASZ81_RS13560	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ASZ81_RS13565	COG1053	succinate dehydrogenase
ASZ81_RS13570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASZ81_RS13575	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ASZ81_RS13585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASZ81_RS13590	COG1509	lysine 2,3-aminomutase activity
ASZ81_RS13600	COG0459	protein refolding
ASZ81_RS13605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASZ81_RS13630	COG0149	triose-phosphate isomerase activity
ASZ81_RS13635	COG0534	Mate efflux family protein
ASZ81_RS13640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ASZ81_RS13645	COG1575	Belongs to the MenA family. Type 1 subfamily
ASZ81_RS13650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ASZ81_RS13655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ASZ81_RS13660	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASZ81_RS13665	COG1609	Transcriptional regulator
ASZ81_RS13670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ASZ81_RS13675	COG0254	rRNA binding
ASZ81_RS13680	COG0281	malic enzyme
ASZ81_RS13685	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ASZ81_RS13690	COG0626	cystathionine gamma-synthase activity
ASZ81_RS13695	COG0527	aspartate kinase activity
ASZ81_RS13695	COG0460	homoserine dehydrogenase
ASZ81_RS13700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ASZ81_RS13705	COG3074	FtsZ-dependent cytokinesis
ASZ81_RS13710	COG1494	fructose-1,6-bisphosphatase
ASZ81_RS13715	COG0205	6-phosphofructokinase activity
ASZ81_RS13720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ASZ81_RS13730	COG0745	RESPONSE REGULATOR receiver
ASZ81_RS13735	COG2205	protein histidine kinase activity
ASZ81_RS13745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ASZ81_RS13750	COG3030	protein affecting phage T7 exclusion by the F plasmid
ASZ81_RS13755	COG3706	GGDEF domain
ASZ81_RS13760	COG1027	Aspartate ammonia-lyase
ASZ81_RS13765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ASZ81_RS13780	COG4232	protein-disulfide reductase activity
ASZ81_RS13800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASZ81_RS13805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ASZ81_RS13810	COG0194	GDP metabolic process
ASZ81_RS13815	COG1758	RNA polymerase activity
ASZ81_RS13820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASZ81_RS13825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ASZ81_RS13830	COG2233	PERMEase
ASZ81_RS13845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASZ81_RS13850	COG2183	response to ionizing radiation
ASZ81_RS13860	COG0596	Alpha beta hydrolase
ASZ81_RS13875	COG1040	competence protein
ASZ81_RS13885	COG0494	nUDIX hydrolase
ASZ81_RS13890	COG1218	3'(2'),5'-bisphosphate nucleotidase
ASZ81_RS13900	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ASZ81_RS13905	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ASZ81_RS13910	COG3156	type II secretion system protein K
ASZ81_RS13915	COG4795	General secretion pathway protein
ASZ81_RS13920	COG2165	general secretion pathway protein
ASZ81_RS13925	COG2165	general secretion pathway protein
ASZ81_RS13930	COG2165	general secretion pathway protein
ASZ81_RS13935	COG1459	type II secretion system
ASZ81_RS13940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASZ81_RS13950	COG3031	protein transport across the cell outer membrane
ASZ81_RS13955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ASZ81_RS13960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ASZ81_RS13965	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ASZ81_RS13975	COG0456	acetyltransferase
ASZ81_RS13980	COG1490	D-aminoacyl-tRNA deacylase activity
ASZ81_RS13985	COG1295	ribonuclease BN
ASZ81_RS13995	COG1217	gtp-binding protein TYPA
ASZ81_RS14005	COG0174	glutamine synthetase
ASZ81_RS14015	COG3852	Histidine kinase
ASZ81_RS14025	COG5001	Diguanylate cyclase
ASZ81_RS14025	COG3300	MHYT domain
ASZ81_RS14030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASZ81_RS14115	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ASZ81_RS14120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASZ81_RS14125	COG1739	Uncharacterized protein family UPF0029
ASZ81_RS14135	COG0183	Belongs to the thiolase family
ASZ81_RS14140	COG0583	DNA-binding transcription factor activity
ASZ81_RS14145	COG2814	Major facilitator Superfamily
ASZ81_RS14150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASZ81_RS14155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASZ81_RS14160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASZ81_RS14165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASZ81_RS14170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASZ81_RS14175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASZ81_RS14180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASZ81_RS14190	COG0356	it plays a direct role in the translocation of protons across the membrane
ASZ81_RS14195	COG3312	ion transport
ASZ81_RS14200	COG1475	DNA binding
ASZ81_RS14205	COG1192	Involved in chromosome partitioning
ASZ81_RS14215	COG0445	tRNA wobble uridine modification
ASZ81_RS14230	COG0706	membrane insertase activity
ASZ81_RS14260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASZ81_RS14370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASZ81_RS14425	COG0408	coproporphyrinogen oxidase activity
ASZ81_RS14565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASZ81_RS14760	COG3287	FIST C domain
ASZ81_RS14760	COG2199	diguanylate cyclase activity
ASZ81_RS14760	COG2200	EAL domain
ASZ81_RS14815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ81_RS14840	COG4206	TonB-dependent receptor
ASZ81_RS14895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASZ81_RS15030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ81_RS15115	COG4774	siderophore transport
ASZ81_RS15150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ81_RS15150	COG1263	PTS System
ASZ81_RS15395	COG0668	transmembrane transport
ASZ81_RS15585	COG2814	Major facilitator Superfamily
ASZ81_RS15790	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ASZ81_RS15790	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ASZ81_RS15805	COG1072	(Pantothenic acid kinase))
ASZ81_RS15820	COG1072	(Pantothenic acid kinase))
ASZ81_RS15850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASZ81_RS15905	COG0085	RNA polymerase activity
ASZ81_RS15920	COG0085	RNA polymerase activity
ASZ81_RS15930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASZ81_RS15935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASZ81_RS15945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASZ81_RS15965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASZ81_RS16050	COG0688	phosphatidylethanolamine metabolic process
ASZ81_RS16135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ASZ81_RS16160	COG1923	regulation of RNA biosynthetic process
ASZ81_RS16260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ81_RS16270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ81_RS16280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ81_RS16445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ81_RS16470	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASZ81_RS16640	COG0646	methionine synthase
ASZ81_RS16640	COG1410	methionine synthase
ASZ81_RS16970	COG1077	Cell shape determining protein MreB Mrl
ASZ81_RS16995	COG0424	maF-like protein
ASZ81_RS17070	COG0312	modulator of DNA gyrase
ASZ81_RS17260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASZ81_RS17300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ASZ81_RS17325	COG0126	phosphoglycerate kinase activity
ASZ81_RS17680	COG0527	aspartate kinase activity
ASZ81_RS17705	COG0612	Peptidase, M16
ASZ81_RS17755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASZ81_RS18265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASZ81_RS18590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASZ81_RS18630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASZ81_RS18785	COG1021	2,3-dihydroxybenzoate-AMP ligase
ASZ81_RS18820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASZ81_RS19095	COG2165	general secretion pathway protein
ASZ81_RS19165	COG0739	heme binding
ASZ81_RS19195	COG3064	Membrane
ASZ81_RS19235	COG0497	DNA recombination
ASZ81_RS19755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ81_RS19865	COG0367	asparagine synthase
ASZ81_RS19950	COG2056	Na+-H+ antiporter family