locus-tag	class	description
OFY13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OFY13_RS00010	COG0592	DNA-directed DNA polymerase activity
OFY13_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OFY13_RS00020	COG0187	DNA topoisomerase II activity
OFY13_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
OFY13_RS00035	COG3977	Valine--pyruvate aminotransferase
OFY13_RS00040	COG0751	glycine-tRNA ligase activity
OFY13_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
OFY13_RS00050	COG2119	membrane
OFY13_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
OFY13_RS00070	COG0604	alcohol dehydrogenase
OFY13_RS00080	COG0129	dihydroxy-acid dehydratase activity
OFY13_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OFY13_RS00100	COG0606	chelatase, subunit chli
OFY13_RS00105	COG0204	Acyl-transferase
OFY13_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFY13_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OFY13_RS00125	COG3084	Protein conserved in bacteria
OFY13_RS00135	COG4326	sporulation control protein
OFY13_RS00140	COG1272	protein, Hemolysin III
OFY13_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFY13_RS00155	COG0569	domain protein
OFY13_RS00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OFY13_RS00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OFY13_RS00165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OFY13_RS00170	COG0242	peptide deformylase activity
OFY13_RS00175	COG1652	LysM domain
OFY13_RS00180	COG0758	DNA mediated transformation
OFY13_RS00185	COG2922	Belongs to the Smg family
OFY13_RS00190	COG0551	DNA topoisomerase type I activity
OFY13_RS00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OFY13_RS00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OFY13_RS00205	COG0009	L-threonylcarbamoyladenylate synthase
OFY13_RS00210	COG0408	coproporphyrinogen oxidase activity
OFY13_RS00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OFY13_RS00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OFY13_RS00265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OFY13_RS00270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OFY13_RS00280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OFY13_RS00285	COG2104	thiamine diphosphate biosynthetic process
OFY13_RS00290	COG2022	thiamine diphosphate biosynthetic process
OFY13_RS00295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OFY13_RS00300	COG0006	proline dipeptidase activity
OFY13_RS00300	COG0006	proline dipeptidase activity
OFY13_RS00320	COG1522	sequence-specific DNA binding
OFY13_RS00325	COG5002	protein histidine kinase activity
OFY13_RS00325	COG5001	Diguanylate cyclase
OFY13_RS00345	COG0589	response to stress
OFY13_RS00350	COG1528	Iron-storage protein
OFY13_RS00360	COG2081	HI0933 family
OFY13_RS00370	COG1322	Protein conserved in bacteria
OFY13_RS00375	COG2226	methyltransferase
OFY13_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OFY13_RS00395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OFY13_RS00400	COG0805	protein transport
OFY13_RS00405	COG1858	cytochrome C peroxidase
OFY13_RS00410	COG0534	Mate efflux family protein
OFY13_RS00420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OFY13_RS00425	COG2937	Belongs to the GPAT DAPAT family
OFY13_RS00430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OFY13_RS00435	COG3161	chorismate lyase activity
OFY13_RS00440	COG1580	Controls the rotational direction of flagella during chemotaxis
OFY13_RS00445	COG0840	transmembrane signaling receptor activity
OFY13_RS00455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFY13_RS00460	COG0084	hydrolase, TatD family'
OFY13_RS00475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFY13_RS00475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFY13_RS00495	COG3078	GTPase activator activity
OFY13_RS00510	COG3071	HemY protein
OFY13_RS00515	COG2959	enzyme of heme biosynthesis
OFY13_RS00520	COG1587	Uroporphyrinogen-III synthase
OFY13_RS00525	COG0181	hydroxymethylbilane synthase activity
OFY13_RS00535	COG1965	Belongs to the frataxin family
OFY13_RS00545	COG0019	diaminopimelate decarboxylase activity
OFY13_RS00550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OFY13_RS00560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OFY13_RS00565	COG1011	Hydrolase
OFY13_RS00570	COG2199	diguanylate cyclase activity
OFY13_RS00570	COG2200	EAL domain
OFY13_RS00570	COG3287	FIST C domain
OFY13_RS00585	COG0561	phosphatase activity
OFY13_RS00590	COG2267	carboxylic ester hydrolase activity
OFY13_RS00595	COG1280	lysine exporter protein (LysE YggA)
OFY13_RS00600	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
OFY13_RS00605	COG0783	Belongs to the Dps family
OFY13_RS00635	COG0742	ribosomal rna small subunit methyltransferase
OFY13_RS00640	COG0552	protein localization to endoplasmic reticulum
OFY13_RS00645	COG2884	Cell division ATP-binding protein ftsE
OFY13_RS00650	COG2177	Part of the ABC transporter FtsEX involved in
OFY13_RS00655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OFY13_RS00660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFY13_RS00675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OFY13_RS00680	COG4206	TonB-dependent receptor
OFY13_RS00685	COG1404	Belongs to the peptidase S8 family
OFY13_RS00690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OFY13_RS00760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OFY13_RS00765	COG5001	Diguanylate cyclase
OFY13_RS00765	COG3300	MHYT domain
OFY13_RS00775	COG3852	Histidine kinase
OFY13_RS00785	COG0174	glutamine synthetase
OFY13_RS00795	COG1217	gtp-binding protein TYPA
OFY13_RS00805	COG1295	ribonuclease BN
OFY13_RS00810	COG1490	D-aminoacyl-tRNA deacylase activity
OFY13_RS00815	COG0456	acetyltransferase
OFY13_RS00825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OFY13_RS00830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OFY13_RS00835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OFY13_RS00840	COG3031	protein transport across the cell outer membrane
OFY13_RS00850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFY13_RS00855	COG1459	type II secretion system
OFY13_RS00860	COG2165	general secretion pathway protein
OFY13_RS00865	COG2165	general secretion pathway protein
OFY13_RS00870	COG2165	general secretion pathway protein
OFY13_RS00875	COG4795	General secretion pathway protein
OFY13_RS00880	COG3156	type II secretion system protein K
OFY13_RS00885	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
OFY13_RS00890	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
OFY13_RS00900	COG1218	3'(2'),5'-bisphosphate nucleotidase
OFY13_RS00905	COG0494	nUDIX hydrolase
OFY13_RS00915	COG1040	competence protein
OFY13_RS00925	COG0596	Alpha beta hydrolase
OFY13_RS00935	COG2183	response to ionizing radiation
OFY13_RS00940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFY13_RS00945	COG2199	diguanylate cyclase activity
OFY13_RS00960	COG2233	PERMEase
OFY13_RS00965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OFY13_RS00970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OFY13_RS00975	COG1758	RNA polymerase activity
OFY13_RS00980	COG0194	GDP metabolic process
OFY13_RS00985	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
OFY13_RS00990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFY13_RS01010	COG4232	protein-disulfide reductase activity
OFY13_RS01020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OFY13_RS01025	COG1027	Aspartate ammonia-lyase
OFY13_RS01030	COG3706	GGDEF domain
OFY13_RS01035	COG3030	protein affecting phage T7 exclusion by the F plasmid
OFY13_RS01040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OFY13_RS01050	COG2205	protein histidine kinase activity
OFY13_RS01055	COG0745	RESPONSE REGULATOR receiver
OFY13_RS01065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OFY13_RS01070	COG0205	6-phosphofructokinase activity
OFY13_RS01075	COG1494	fructose-1,6-bisphosphatase
OFY13_RS01080	COG3074	FtsZ-dependent cytokinesis
OFY13_RS01085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OFY13_RS01090	COG0527	aspartate kinase activity
OFY13_RS01090	COG0460	homoserine dehydrogenase
OFY13_RS01095	COG0626	cystathionine gamma-synthase activity
OFY13_RS01100	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
OFY13_RS01105	COG0281	malic enzyme
OFY13_RS01110	COG0254	rRNA binding
OFY13_RS01115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OFY13_RS01120	COG1609	Transcriptional regulator
OFY13_RS01125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OFY13_RS01130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OFY13_RS01135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OFY13_RS01140	COG1575	Belongs to the MenA family. Type 1 subfamily
OFY13_RS01145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OFY13_RS01150	COG0534	Mate efflux family protein
OFY13_RS01155	COG0149	triose-phosphate isomerase activity
OFY13_RS01180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OFY13_RS01185	COG0459	protein refolding
OFY13_RS01195	COG1509	lysine 2,3-aminomutase activity
OFY13_RS01200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OFY13_RS01210	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
OFY13_RS01215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OFY13_RS01220	COG1053	succinate dehydrogenase
OFY13_RS01225	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OFY13_RS01230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFY13_RS01235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OFY13_RS01240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OFY13_RS01245	COG1045	serine acetyltransferase
OFY13_RS01255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OFY13_RS01260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OFY13_RS01265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OFY13_RS01270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OFY13_RS01275	COG0137	argininosuccinate synthase activity
OFY13_RS01280	COG0165	Argininosuccinate lyase
OFY13_RS01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFY13_RS01295	COG0678	peroxiredoxin activity
OFY13_RS01295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OFY13_RS01305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OFY13_RS01335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OFY13_RS01340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OFY13_RS01350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
OFY13_RS01355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OFY13_RS01360	COG0546	phosphoglycolate phosphatase activity
OFY13_RS01365	COG0180	Tryptophanyl-tRNA synthetase
OFY13_RS01380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OFY13_RS01390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OFY13_RS01415	COG3954	Phosphoribulokinase
OFY13_RS01425	COG0429	hydrolase of the alpha beta-hydrolase fold
OFY13_RS01435	COG0488	(ABC) transporter
OFY13_RS01440	COG2249	NAD(P)H dehydrogenase (quinone) activity
OFY13_RS01455	COG1047	Peptidyl-prolyl cis-trans
OFY13_RS01465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OFY13_RS01470	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
OFY13_RS01475	COG3083	sulfuric ester hydrolase activity
OFY13_RS01480	COG0557	exoribonuclease II activity
OFY13_RS01485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFY13_RS01490	COG0051	transcription antitermination factor activity, RNA binding
OFY13_RS01495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OFY13_RS01500	COG0088	Forms part of the polypeptide exit tunnel
OFY13_RS01505	COG0089	rRNA binding
OFY13_RS01510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OFY13_RS01515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OFY13_RS01520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OFY13_RS01525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OFY13_RS01530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OFY13_RS01535	COG0255	Belongs to the universal ribosomal protein uL29 family
OFY13_RS01540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OFY13_RS01545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OFY13_RS01550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OFY13_RS01555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OFY13_RS01560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OFY13_RS01565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OFY13_RS01575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OFY13_RS01580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OFY13_RS01585	COG1841	ribosomal large subunit assembly
OFY13_RS01590	COG0200	Binds to the 23S rRNA
OFY13_RS01595	COG0201	protein transport
OFY13_RS01600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OFY13_RS01605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OFY13_RS01610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OFY13_RS01615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OFY13_RS01620	COG0202	RNA polymerase activity
OFY13_RS01625	COG0203	ribosomal protein L17
OFY13_RS01635	COG0545	Peptidyl-prolyl cis-trans isomerase
OFY13_RS01640	COG3061	Opacity-associated protein A
OFY13_RS01640	COG3266	domain, Protein
OFY13_RS01645	COG0697	spore germination
OFY13_RS01650	COG2153	protein acetylation
OFY13_RS01655	COG0513	Belongs to the DEAD box helicase family
OFY13_RS01670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OFY13_RS01670	COG1648	precorrin-2 dehydrogenase activity
OFY13_RS01680	COG2895	sulfate adenylyltransferase (ATP) activity
OFY13_RS01685	COG0529	Catalyzes the synthesis of activated sulfate
OFY13_RS01705	COG1136	(ABC) transporter
OFY13_RS01720	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
OFY13_RS01725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFY13_RS01730	COG0729	surface antigen
OFY13_RS01740	COG2105	PFAM AIG2 family protein
OFY13_RS01745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OFY13_RS01755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OFY13_RS01760	COG0163	prenyltransferase activity
OFY13_RS01770	COG1178	ABC-type Fe3 transport system permease component
OFY13_RS01775	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
OFY13_RS01780	COG3028	Belongs to the UPF0307 family
OFY13_RS01785	COG0312	modulator of DNA gyrase
OFY13_RS01790	COG2239	Acts as a magnesium transporter
OFY13_RS01795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFY13_RS01800	COG1660	Displays ATPase and GTPase activities
OFY13_RS01805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFY13_RS01810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OFY13_RS01820	COG1137	ATPase activity
OFY13_RS01825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OFY13_RS01840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OFY13_RS01840	COG0517	IMP dehydrogenase activity
OFY13_RS01850	COG1127	ABC transporter
OFY13_RS01855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OFY13_RS01860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OFY13_RS01865	COG2854	intermembrane phospholipid transfer
OFY13_RS01875	COG5007	Belongs to the BolA IbaG family
OFY13_RS01880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OFY13_RS01890	COG0251	oxidation-reduction process
OFY13_RS01900	COG0540	Belongs to the ATCase OTCase family
OFY13_RS01910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OFY13_RS01915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OFY13_RS01920	COG0564	pseudouridine synthase activity
OFY13_RS01925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OFY13_RS01930	COG0525	valine-tRNA ligase activity
OFY13_RS01935	COG2927	DNA polymerase III (CHI subunit)
OFY13_RS01940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OFY13_RS01945	COG0795	lipopolysaccharide-transporting ATPase activity
OFY13_RS01950	COG0795	lipopolysaccharide-transporting ATPase activity
OFY13_RS01965	COG3437	response regulator, receiver
OFY13_RS02010	COG0066	3-isopropylmalate dehydratase activity
OFY13_RS02015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OFY13_RS02020	COG0473	3-isopropylmalate dehydrogenase activity
OFY13_RS02045	COG0583	DNA-binding transcription factor activity
OFY13_RS02050	COG1022	Amp-dependent synthetase and ligase
OFY13_RS02055	COG0028	Belongs to the TPP enzyme family
OFY13_RS02060	COG0440	acetolactate synthase activity
OFY13_RS02065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OFY13_RS02070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OFY13_RS02075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OFY13_RS02085	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OFY13_RS02090	COG3079	Belongs to the UPF0149 family
OFY13_RS02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFY13_RS02100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFY13_RS02110	COG0354	folic acid binding
OFY13_RS02115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OFY13_RS02125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OFY13_RS02130	COG1595	DNA-templated transcription, initiation
OFY13_RS02145	COG3086	response to oxidative stress
OFY13_RS02150	COG0481	GTPase activity
OFY13_RS02160	COG0571	ribonuclease III activity
OFY13_RS02165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OFY13_RS02170	COG1381	Involved in DNA repair and RecF pathway recombination
OFY13_RS02175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OFY13_RS02195	COG5001	Diguanylate cyclase
OFY13_RS02210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OFY13_RS02215	COG3956	TIGRFAM MazG family protein
OFY13_RS02220	COG0504	CTP synthase activity
OFY13_RS02225	COG0148	phosphopyruvate hydratase activity
OFY13_RS02235	COG3267	Type II secretory pathway component ExeA
OFY13_RS02235	COG3409	Peptidoglycan-binding domain 1 protein
OFY13_RS02245	COG4991	sh3 domain protein
OFY13_RS02250	COG0306	phosphate transporter
OFY13_RS02255	COG1392	Phosphate transport regulator
OFY13_RS02260	COG3025	triphosphatase activity
OFY13_RS02265	COG0840	transmembrane signaling receptor activity
OFY13_RS02270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OFY13_RS02275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OFY13_RS02275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
OFY13_RS02280	COG1538	Outer membrane efflux protein
OFY13_RS02285	COG0494	nUDIX hydrolase
OFY13_RS02290	COG3151	Protein conserved in bacteria
OFY13_RS02300	COG3150	esterase
OFY13_RS02305	COG0187	DNA topoisomerase II activity
OFY13_RS02310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OFY13_RS02320	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
OFY13_RS02325	COG0237	dephospho-CoA kinase activity
OFY13_RS02335	COG1459	type II secretion system
OFY13_RS02340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFY13_RS02345	COG4969	Belongs to the N-Me-Phe pilin family
OFY13_RS02360	COG0716	FMN binding
OFY13_RS02365	COG4974	Belongs to the 'phage' integrase family
OFY13_RS02370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OFY13_RS02375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OFY13_RS02380	COG0737	Belongs to the 5'-nucleotidase family
OFY13_RS02385	COG2186	Transcriptional regulator
OFY13_RS02390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
OFY13_RS02395	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFY13_RS02400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFY13_RS02415	COG3116	cell division
OFY13_RS02420	COG0768	penicillin binding
OFY13_RS02425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OFY13_RS02430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OFY13_RS02440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OFY13_RS02445	COG0772	Belongs to the SEDS family
OFY13_RS02455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OFY13_RS02460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OFY13_RS02465	COG0849	cell division
OFY13_RS02470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OFY13_RS02475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OFY13_RS02485	COG0653	protein targeting
OFY13_RS02490	COG0494	nUDIX hydrolase
OFY13_RS02495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OFY13_RS02505	COG0505	Belongs to the CarA family
OFY13_RS02510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OFY13_RS02525	COG0730	response to heat
OFY13_RS02530	COG0583	DNA-binding transcription factor activity
OFY13_RS02535	COG2860	membrane
OFY13_RS02540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OFY13_RS02550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OFY13_RS02560	COG0493	'glutamate synthase
OFY13_RS02565	COG0067	glutamate synthase
OFY13_RS02565	COG0069	glutamate synthase activity
OFY13_RS02565	COG0070	glutamate synthase
OFY13_RS02575	COG0070	glutamate synthase
OFY13_RS02575	COG0067	glutamate synthase
OFY13_RS02575	COG0069	glutamate synthase activity
OFY13_RS02580	COG1242	4 iron, 4 sulfur cluster binding
OFY13_RS02585	COG5001	Diguanylate cyclase
OFY13_RS02585	COG4251	negative regulation of phosphorylation
OFY13_RS02585	COG3706	GGDEF domain
OFY13_RS02585	COG2203	Gaf domain
OFY13_RS02590	COG0784	Response regulator, receiver
OFY13_RS02590	COG2198	Histidine kinase
OFY13_RS02590	COG5002	protein histidine kinase activity
OFY13_RS02595	COG0745	RESPONSE REGULATOR receiver
OFY13_RS02605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OFY13_RS02625	COG0083	homoserine kinase activity
OFY13_RS02630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OFY13_RS02635	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
OFY13_RS02640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OFY13_RS02650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OFY13_RS02665	COG1115	amino acid carrier protein
OFY13_RS02670	COG3022	response to hydroperoxide
OFY13_RS02680	COG0084	hydrolase, TatD family'
OFY13_RS02685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFY13_RS02695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OFY13_RS02700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OFY13_RS02705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OFY13_RS02710	COG0813	purine-nucleoside phosphorylase activity
OFY13_RS02720	COG0560	Phosphoserine phosphatase
OFY13_RS02730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OFY13_RS02735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OFY13_RS02740	COG1022	Amp-dependent synthetase and ligase
OFY13_RS02755	COG3250	beta-galactosidase activity
OFY13_RS02760	COG1609	Transcriptional regulator
OFY13_RS02765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFY13_RS02780	COG0189	ligase activity
OFY13_RS02780	COG0569	domain protein
OFY13_RS02785	COG0456	acetyltransferase
OFY13_RS02795	COG2171	N-acyltransferase activity
OFY13_RS02800	COG3141	response to X-ray
OFY13_RS02815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OFY13_RS02820	COG1074	ATP-dependent DNA helicase activity
OFY13_RS02825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OFY13_RS02835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OFY13_RS02835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OFY13_RS02845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
OFY13_RS02850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OFY13_RS02855	COG2166	iron-sulfur cluster assembly
OFY13_RS02860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OFY13_RS02865	COG0693	protein deglycase activity
OFY13_RS02870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OFY13_RS02875	COG3248	Nucleoside-binding outer membrane protein
OFY13_RS02885	COG1595	DNA-templated transcription, initiation
OFY13_RS02895	COG2211	Major facilitator Superfamily
OFY13_RS02910	COG2813	Specifically methylates the guanine in position
OFY13_RS02915	COG0271	Belongs to the BolA IbaG family
OFY13_RS02920	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFY13_RS02925	COG1805	sodium ion transport
OFY13_RS02930	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFY13_RS02935	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFY13_RS02940	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OFY13_RS02945	COG2871	sodium ion transport
OFY13_RS02950	COG1477	protein flavinylation
OFY13_RS02970	COG3706	GGDEF domain
OFY13_RS02975	COG0733	neurotransmitter:sodium symporter activity
OFY13_RS02985	COG0189	ligase activity
OFY13_RS02990	COG4067	protein conserved in archaea
OFY13_RS02990	COG0189	ligase activity
OFY13_RS02995	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFY13_RS03000	COG2252	PERMEase
OFY13_RS03005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
OFY13_RS03010	COG1073	alpha beta
OFY13_RS03020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OFY13_RS03025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OFY13_RS03030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OFY13_RS03035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OFY13_RS03035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OFY13_RS03050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OFY13_RS03055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OFY13_RS03060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OFY13_RS03065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OFY13_RS03075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
OFY13_RS03080	COG0024	Methionine aminopeptidase
OFY13_RS03085	COG0052	Belongs to the universal ribosomal protein uS2 family
OFY13_RS03090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OFY13_RS03095	COG0528	UMP kinase activity
OFY13_RS03100	COG0233	cytoplasmic translational termination
OFY13_RS03105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OFY13_RS03110	COG0575	Belongs to the CDS family
OFY13_RS03115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OFY13_RS03120	COG0750	zinc metalloprotease
OFY13_RS03130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
OFY13_RS03135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFY13_RS03140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OFY13_RS03145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFY13_RS03150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFY13_RS03155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OFY13_RS03160	COG0587	DNA-directed DNA polymerase activity
OFY13_RS03165	COG0825	malonyl-CoA metabolic process
OFY13_RS03170	COG0037	tRNA processing
OFY13_RS03180	COG3479	Phenolic acid decarboxylase
OFY13_RS03185	COG0347	Belongs to the P(II) protein family
OFY13_RS03190	COG3021	interspecies interaction between organisms
OFY13_RS03195	COG1388	LysM domain
OFY13_RS03195	COG0741	lytic transglycosylase activity
OFY13_RS03200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OFY13_RS03205	COG2226	methyltransferase
OFY13_RS03210	COG0328	RNA-DNA hybrid ribonuclease activity
OFY13_RS03225	COG1960	acyl-CoA dehydrogenase activity
OFY13_RS03230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OFY13_RS03235	COG0121	glutamine amidotransferase
OFY13_RS03240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OFY13_RS03245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OFY13_RS03250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OFY13_RS03260	COG1187	pseudouridine synthase activity
OFY13_RS03265	COG2840	Smr protein MutS2
OFY13_RS03280	COG3735	TraB family
OFY13_RS03295	COG2217	Heavy metal translocating P-type atpase
OFY13_RS03295	COG2608	mercury ion transmembrane transporter activity
OFY13_RS03300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OFY13_RS03315	COG4774	siderophore transport
OFY13_RS03315	COG1629	transport
OFY13_RS03320	COG2375	cellular response to nickel ion
OFY13_RS03325	COG3433	isochorismatase activity
OFY13_RS03325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OFY13_RS03325	COG2226	methyltransferase
OFY13_RS03365	COG0784	Response regulator, receiver
OFY13_RS03365	COG0835	chemotaxis
OFY13_RS03370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OFY13_RS03375	COG1815	bacterial-type flagellum-dependent cell motility
OFY13_RS03390	COG1749	Flagellar hook protein flgE
OFY13_RS03395	COG4787	bacterial-type flagellum-dependent cell motility
OFY13_RS03405	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
OFY13_RS03410	COG1706	bacterial-type flagellum-dependent cell motility
OFY13_RS03415	COG3951	Flagellar rod assembly protein muramidase FlgJ
OFY13_RS03415	COG1705	Flagellar rod assembly protein muramidase FlgJ
OFY13_RS03430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFY13_RS03435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFY13_RS03525	COG0012	GTP binding
OFY13_RS03530	COG0193	aminoacyl-tRNA hydrolase activity
OFY13_RS03535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OFY13_RS03540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OFY13_RS03545	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OFY13_RS03550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OFY13_RS03555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OFY13_RS03560	COG2890	protein-(glutamine-N5) methyltransferase activity
OFY13_RS03570	COG2912	Transglutaminase-like superfamily
OFY13_RS03575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OFY13_RS03580	COG0737	Belongs to the 5'-nucleotidase family
OFY13_RS03585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OFY13_RS03590	COG2233	PERMEase
OFY13_RS03610	COG1393	Belongs to the ArsC family
OFY13_RS03615	COG4783	chaperone-mediated protein folding
OFY13_RS03635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OFY13_RS03650	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
OFY13_RS03660	COG1876	peptidase activity
OFY13_RS03670	COG1393	Belongs to the ArsC family
OFY13_RS03690	COG2837	iron assimilation
OFY13_RS03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFY13_RS03700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFY13_RS03705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OFY13_RS03710	COG1334	flagellar protein FlaG
OFY13_RS03715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OFY13_RS03725	COG1516	flagellar protein fliS
OFY13_RS03745	COG1677	Flagellar hook-basal body complex protein FliE
OFY13_RS03755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OFY13_RS03760	COG1317	bacterial-type flagellum organization
OFY13_RS03785	COG1580	Controls the rotational direction of flagella during chemotaxis
OFY13_RS03810	COG1987	bacterial-type flagellum assembly
OFY13_RS03815	COG1684	flagellar biosynthetic protein fliR
OFY13_RS03825	COG2840	Smr protein MutS2
OFY13_RS03830	COG2890	protein-(glutamine-N5) methyltransferase activity
OFY13_RS03835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OFY13_RS03840	COG2860	membrane
OFY13_RS03845	COG3101	peptidyl-lysine hydroxylation
OFY13_RS03855	COG0431	NADPH-dependent FMN reductase
OFY13_RS03860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
OFY13_RS03860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OFY13_RS03865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OFY13_RS03870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OFY13_RS03875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OFY13_RS03880	COG0735	belongs to the Fur family
OFY13_RS03890	COG0583	DNA-binding transcription factor activity
OFY13_RS03900	COG1346	cytolysis
OFY13_RS03915	COG0596	Alpha beta hydrolase
OFY13_RS03920	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
OFY13_RS03925	COG0033	Phosphoglucomutase
OFY13_RS03935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OFY13_RS03940	COG0372	Belongs to the citrate synthase family
OFY13_RS03945	COG2009	succinate dehydrogenase
OFY13_RS03950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OFY13_RS03955	COG1053	succinate dehydrogenase
OFY13_RS03965	COG0567	Dehydrogenase, E1 component
OFY13_RS03970	COG0508	dehydrogenase complex catalyzes the overall conversion of
OFY13_RS03975	COG0045	succinate-CoA ligase (ADP-forming) activity
OFY13_RS03985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OFY13_RS03990	COG1121	(ABC) transporter
OFY13_RS03995	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
OFY13_RS04000	COG4977	sequence-specific DNA binding
OFY13_RS04005	COG1918	ferrous iron import across plasma membrane
OFY13_RS04025	COG0018	arginyl-trna synthetase
OFY13_RS04035	COG1025	Belongs to the peptidase M16 family
OFY13_RS04040	COG2062	phosphohistidine phosphatase, SixA
OFY13_RS04070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
OFY13_RS04075	COG0784	Response regulator, receiver
OFY13_RS04075	COG2198	Histidine kinase
OFY13_RS04075	COG0643	Histidine kinase
OFY13_RS04080	COG2201	protein-glutamate methylesterase activity
OFY13_RS04085	COG1192	Involved in chromosome partitioning
OFY13_RS04095	COG0835	chemotaxis
OFY13_RS04105	COG4133	protoheme IX ABC transporter activity
OFY13_RS04110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFY13_RS04115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OFY13_RS04125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OFY13_RS04130	COG1138	Cytochrome C-type biogenesis protein
OFY13_RS04135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OFY13_RS04140	COG4235	cytochrome complex assembly
OFY13_RS04140	COG3088	subunit of a heme lyase
OFY13_RS04150	COG2853	Lipoprotein
OFY13_RS04170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OFY13_RS04175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OFY13_RS04180	COG0123	including yeast histone deacetylase and acetoin utilization protein
OFY13_RS04195	COG3083	sulfuric ester hydrolase activity
OFY13_RS04200	COG3082	Protein of unknown function (DUF1414)
OFY13_RS04205	COG3081	Nucleoid-associated protein
OFY13_RS04215	COG1757	Na H antiporter
OFY13_RS04220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OFY13_RS04225	COG2095	MarC family integral membrane protein
OFY13_RS04230	COG1012	belongs to the aldehyde dehydrogenase family
OFY13_RS04230	COG1454	alcohol dehydrogenase
OFY13_RS04240	COG0659	secondary active sulfate transmembrane transporter activity
OFY13_RS04245	COG1530	ribonuclease E activity
OFY13_RS04250	COG0564	pseudouridine synthase activity
OFY13_RS04255	COG0424	maF-like protein
OFY13_RS04260	COG1399	metal-binding, possibly nucleic acid-binding protein
OFY13_RS04265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OFY13_RS04270	COG0416	fatty acid biosynthetic process
OFY13_RS04275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OFY13_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
OFY13_RS04290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OFY13_RS04295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OFY13_RS04300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OFY13_RS04305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OFY13_RS04310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OFY13_RS04320	COG0084	hydrolase, TatD family'
OFY13_RS04325	COG1263	PTS System
OFY13_RS04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFY13_RS04335	COG0733	neurotransmitter:sodium symporter activity
OFY13_RS04350	COG4667	esterase of the alpha-beta hydrolase superfamily
OFY13_RS04360	COG1940	carbohydrate kinase activity
OFY13_RS04365	COG0784	Response regulator, receiver
OFY13_RS04365	COG0835	chemotaxis
OFY13_RS04380	COG2226	methyltransferase
OFY13_RS04390	COG0676	glucose-6-phosphate 1-epimerase activity
OFY13_RS04395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFY13_RS04400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFY13_RS04410	COG3139	Protein of unknown function (DUF1315)
OFY13_RS04415	COG0252	asparaginase activity
OFY13_RS04420	COG0616	signal peptide processing
OFY13_RS04425	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFY13_RS04425	COG1902	pentaerythritol trinitrate reductase activity
OFY13_RS04430	COG0788	formyltetrahydrofolate deformylase activity
OFY13_RS04440	COG1199	ATP-dependent helicase activity
OFY13_RS04445	COG1214	PFAM Peptidase M22, glycoprotease
OFY13_RS04460	COG0596	Alpha beta hydrolase
OFY13_RS04465	COG0318	PFAM AMP-dependent synthetase and ligase
OFY13_RS04470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
OFY13_RS04485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
OFY13_RS04490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OFY13_RS04495	COG0436	Aminotransferase
OFY13_RS04500	COG1169	isochorismate synthase
OFY13_RS04505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OFY13_RS04510	COG0596	Alpha beta hydrolase
OFY13_RS04530	COG3135	benzoate transporter
OFY13_RS04535	COG1396	sequence-specific DNA binding
OFY13_RS04540	COG0840	transmembrane signaling receptor activity
OFY13_RS04570	COG3015	lipoprotein NlpE involved in copper resistance
OFY13_RS04575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
OFY13_RS04580	COG2894	cell division
OFY13_RS04585	COG0850	regulation of cytokinetic process
OFY13_RS04590	COG3100	YcgL domain-containing protein
OFY13_RS04595	COG2951	lytic endotransglycosylase activity
OFY13_RS04605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFY13_RS04610	COG3469	chitinase activity
OFY13_RS04610	COG3325	Belongs to the glycosyl hydrolase 18 family
OFY13_RS04615	COG3005	denitrification pathway
OFY13_RS04620	COG0243	molybdopterin cofactor binding
OFY13_RS04635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFY13_RS04645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OFY13_RS04680	COG4589	Belongs to the CDS family
OFY13_RS04690	COG3300	MHYT domain
OFY13_RS04690	COG5001	Diguanylate cyclase
OFY13_RS04700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OFY13_RS04705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFY13_RS04710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFY13_RS04715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFY13_RS04725	COG4191	Histidine kinase
OFY13_RS04735	COG0544	peptidyl-prolyl cis-trans isomerase activity
OFY13_RS04745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OFY13_RS04750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OFY13_RS04755	COG0776	regulation of translation
OFY13_RS04760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFY13_RS04765	COG1555	photosystem II stabilization
OFY13_RS04770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OFY13_RS04775	COG0539	negative regulation of cytoplasmic translation
OFY13_RS04780	COG0776	regulation of translation
OFY13_RS04785	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
OFY13_RS04790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OFY13_RS04830	COG0583	DNA-binding transcription factor activity
OFY13_RS04840	COG0686	Belongs to the AlaDH PNT family
OFY13_RS04850	COG1674	ftsk spoiiie
OFY13_RS04855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
OFY13_RS04860	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFY13_RS04865	COG2186	Transcriptional regulator
OFY13_RS04880	COG0537	adenosine 5'-monophosphoramidase activity
OFY13_RS04905	COG3150	esterase
OFY13_RS04910	COG1252	NADH dehydrogenase
OFY13_RS04930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OFY13_RS04940	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFY13_RS04945	COG1136	(ABC) transporter
OFY13_RS04950	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFY13_RS04960	COG0658	competence protein
OFY13_RS04960	COG2333	competence protein COMEC
OFY13_RS04965	COG1132	(ABC) transporter
OFY13_RS04970	COG1663	tetraacyldisaccharide 4'-kinase activity
OFY13_RS04975	COG2835	tetraacyldisaccharide 4'-kinase activity
OFY13_RS04980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OFY13_RS04985	COG2719	SpoVR family
OFY13_RS04990	COG2718	Belongs to the UPF0229 family
OFY13_RS04995	COG2766	serine protein kinase
OFY13_RS05000	COG3013	Belongs to the UPF0304 family
OFY13_RS05010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OFY13_RS05015	COG0840	transmembrane signaling receptor activity
OFY13_RS05025	COG1882	Formate acetyltransferase
OFY13_RS05050	COG4160	amino acid transport
OFY13_RS05055	COG0708	Exodeoxyribonuclease III
OFY13_RS05060	COG0840	transmembrane signaling receptor activity
OFY13_RS05070	COG3923	Primosomal replication protein n
OFY13_RS05075	COG0730	response to heat
OFY13_RS05080	COG1199	ATP-dependent helicase activity
OFY13_RS05095	COG3012	SEC-C Motif Domain Protein
OFY13_RS05100	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
OFY13_RS05105	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OFY13_RS05110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OFY13_RS05115	COG0215	cysteine-tRNA ligase activity
OFY13_RS05120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OFY13_RS05125	COG0632	four-way junction helicase activity
OFY13_RS05135	COG1271	oxidase subunit
OFY13_RS05140	COG1294	oxidase, subunit
OFY13_RS05145	COG4890	Cyd operon protein YbgT
OFY13_RS05155	COG0824	Thioesterase
OFY13_RS05160	COG0811	peptide transport
OFY13_RS05175	COG0823	Involved in the tonB-independent uptake of proteins
OFY13_RS05180	COG2885	chlorophyll binding
OFY13_RS05190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OFY13_RS05200	COG0784	Response regulator, receiver
OFY13_RS05200	COG5002	protein histidine kinase activity
OFY13_RS05210	COG1482	cell wall glycoprotein biosynthetic process
OFY13_RS05215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFY13_RS05215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFY13_RS05215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFY13_RS05220	COG2207	Transcriptional regulator
OFY13_RS05230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFY13_RS05235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFY13_RS05240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFY13_RS05250	COG1012	belongs to the aldehyde dehydrogenase family
OFY13_RS05255	COG3284	Transcriptional regulator
OFY13_RS05260	COG4628	conserved protein (DUF2132)
OFY13_RS05270	COG0415	Belongs to the DNA photolyase family
OFY13_RS05320	COG2003	Belongs to the UPF0758 family
OFY13_RS05330	COG4409	exo-alpha-(2->6)-sialidase activity
OFY13_RS05335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OFY13_RS05340	COG1940	carbohydrate kinase activity
OFY13_RS05350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OFY13_RS05355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OFY13_RS05360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OFY13_RS05365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OFY13_RS05370	COG1737	Transcriptional regulator
OFY13_RS05375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
OFY13_RS05380	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
OFY13_RS05390	COG4932	domain protein
OFY13_RS05390	COG5492	domain, Protein
OFY13_RS05415	COG2267	carboxylic ester hydrolase activity
OFY13_RS05425	COG3064	Membrane
OFY13_RS05530	COG4789	Type iii secretion
OFY13_RS05535	COG4792	protein secretion
OFY13_RS05565	COG3710	Transcriptional regulator
OFY13_RS05575	COG4790	Type iii secretion
OFY13_RS05655	COG0582	viral genome integration into host DNA
OFY13_RS05670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFY13_RS05680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OFY13_RS05680	COG3008	intermembrane lipid transfer
OFY13_RS05685	COG2995	paraquat-inducible protein a
OFY13_RS05690	COG1309	transcriptional regulator
OFY13_RS05695	COG1012	belongs to the aldehyde dehydrogenase family
OFY13_RS05715	COG1960	acyl-CoA dehydrogenase activity
OFY13_RS05720	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OFY13_RS05725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OFY13_RS05730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OFY13_RS05735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OFY13_RS05750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OFY13_RS05755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OFY13_RS05760	COG0297	glycogen (starch) synthase activity
OFY13_RS05780	COG3070	regulator of competence-specific genes
OFY13_RS05785	COG1609	Transcriptional regulator
OFY13_RS05795	COG0745	RESPONSE REGULATOR receiver
OFY13_RS05800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OFY13_RS05805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFY13_RS05810	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
OFY13_RS05815	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
OFY13_RS05835	COG1032	radical SAM domain protein
OFY13_RS05840	COG5001	Diguanylate cyclase
OFY13_RS05845	COG0612	Peptidase, M16
OFY13_RS05860	COG0583	DNA-binding transcription factor activity
OFY13_RS05865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OFY13_RS05875	COG2350	Protein conserved in bacteria
OFY13_RS05880	COG1607	acyl-coa hydrolase
OFY13_RS05895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
OFY13_RS05900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OFY13_RS05910	COG2116	formate transmembrane transporter activity
OFY13_RS05915	COG4459	periplasmic nitrate reductase
OFY13_RS05920	COG3005	denitrification pathway
OFY13_RS05925	COG0243	molybdopterin cofactor binding
OFY13_RS05940	COG1227	inorganic diphosphatase activity
OFY13_RS05955	COG4172	Belongs to the ABC transporter superfamily
OFY13_RS05970	COG4168	peptide transport system, permease
OFY13_RS05980	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OFY13_RS05985	COG1842	Phage shock protein A
OFY13_RS06000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFY13_RS06015	COG2818	Glycosylase
OFY13_RS06020	COG0626	cystathionine gamma-synthase activity
OFY13_RS06030	COG0733	neurotransmitter:sodium symporter activity
OFY13_RS06035	COG0564	pseudouridine synthase activity
OFY13_RS06040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OFY13_RS06045	COG4136	ATPase activity
OFY13_RS06050	COG4135	transport system, permease component
OFY13_RS06055	COG4134	Bacterial extracellular solute-binding protein
OFY13_RS06065	COG3313	Fe-S protein
OFY13_RS06075	COG0842	Transport permease protein
OFY13_RS06080	COG1131	(ABC) transporter
OFY13_RS06085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFY13_RS06090	COG0814	amino acid
OFY13_RS06100	COG2239	Acts as a magnesium transporter
OFY13_RS06105	COG0784	Response regulator, receiver
OFY13_RS06105	COG2205	protein histidine kinase activity
OFY13_RS06120	COG4934	collagen metabolic process
OFY13_RS06160	COG5001	Diguanylate cyclase
OFY13_RS06160	COG2203	Gaf domain
OFY13_RS06160	COG4251	negative regulation of phosphorylation
OFY13_RS06160	COG3706	GGDEF domain
OFY13_RS06165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OFY13_RS06185	COG1061	Type III restriction enzyme res subunit
OFY13_RS06190	COG1187	pseudouridine synthase activity
OFY13_RS06195	COG2814	Major facilitator Superfamily
OFY13_RS06205	COG0702	epimerase
OFY13_RS06210	COG0534	Mate efflux family protein
OFY13_RS06215	COG4181	ATPase activity
OFY13_RS06220	COG0577	efflux transmembrane transporter activity
OFY13_RS06230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OFY13_RS06240	COG1748	Saccharopine dehydrogenase
OFY13_RS06255	COG1538	Outer membrane efflux protein
OFY13_RS06275	COG0583	DNA-binding transcription factor activity
OFY13_RS06285	COG1451	nucleotide metabolic process
OFY13_RS06300	COG3063	Type IV pilus biogenesis stability protein PilW
OFY13_RS06305	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OFY13_RS06325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFY13_RS06345	COG4565	transcriptional regulatory protein
OFY13_RS06355	COG0784	Response regulator, receiver
OFY13_RS06355	COG0835	chemotaxis
OFY13_RS06400	COG1085	galactose-1-phosphate uridylyltransferase
OFY13_RS06405	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OFY13_RS06410	COG2017	converts alpha-aldose to the beta-anomer
OFY13_RS06420	COG2199	diguanylate cyclase activity
OFY13_RS06420	COG2200	EAL domain
OFY13_RS06435	COG3527	Alpha-acetolactate decarboxylase
OFY13_RS06450	COG0753	catalase activity
OFY13_RS06470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OFY13_RS06480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OFY13_RS06495	COG3097	Belongs to the UPF0267 family
OFY13_RS06520	COG1271	oxidase subunit
OFY13_RS06525	COG1294	oxidase, subunit
OFY13_RS06530	COG4591	ABC-type transport system involved in lipoprotein release permease component
OFY13_RS06530	COG1136	(ABC) transporter
OFY13_RS06535	COG0577	efflux transmembrane transporter activity
OFY13_RS06535	COG1136	(ABC) transporter
OFY13_RS06540	COG1136	(ABC) transporter
OFY13_RS06540	COG0577	efflux transmembrane transporter activity
OFY13_RS06570	COG2723	6-phospho-beta-galactosidase activity
OFY13_RS06575	COG1609	Transcriptional regulator
OFY13_RS06580	COG0251	oxidation-reduction process
OFY13_RS06585	COG2731	YhcH YjgK YiaL family protein
OFY13_RS06590	COG0584	glycerophosphoryl diester phosphodiesterase
OFY13_RS06595	COG1349	DNA-binding transcription factor activity
OFY13_RS06600	COG3842	ATPase activity
OFY13_RS06605	COG0395	ABC-type sugar transport system, permease component
OFY13_RS06610	COG1175	transmembrane transport
OFY13_RS06625	COG0811	peptide transport
OFY13_RS06630	COG0811	peptide transport
OFY13_RS06635	COG0848	biopolymer transport protein
OFY13_RS06640	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
OFY13_RS06650	COG1793	dna ligase
OFY13_RS06660	COG0534	Mate efflux family protein
OFY13_RS06670	COG3001	Fructosamine kinase
OFY13_RS06680	COG0791	NLP P60 protein
OFY13_RS06685	COG0840	transmembrane signaling receptor activity
OFY13_RS06685	COG3290	protein histidine kinase activity
OFY13_RS06695	COG3148	PFAM DTW domain containing protein
OFY13_RS06700	COG1940	carbohydrate kinase activity
OFY13_RS06710	COG0303	'Molybdopterin
OFY13_RS06715	COG0746	molybdenum cofactor guanylyltransferase activity
OFY13_RS06720	COG3842	ATPase activity
OFY13_RS06725	COG4662	Binding-protein-dependent transport system inner membrane component
OFY13_RS06735	COG2204	response regulator
OFY13_RS06740	COG3852	Histidine kinase
OFY13_RS06745	COG0488	(ABC) transporter
OFY13_RS06750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OFY13_RS06780	COG3383	formate dehydrogenase (NAD+) activity
OFY13_RS06780	COG0243	molybdopterin cofactor binding
OFY13_RS06785	COG0437	4 iron, 4 sulfur cluster binding
OFY13_RS06800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OFY13_RS06805	COG1666	GTP binding
OFY13_RS06810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFY13_RS06825	COG2996	Protein conserved in bacteria
OFY13_RS06835	COG3008	intermembrane lipid transfer
OFY13_RS06840	COG2995	paraquat-inducible protein a
OFY13_RS06845	COG1132	(ABC) transporter
OFY13_RS06850	COG1956	GAF domain-containing protein
OFY13_RS06855	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
OFY13_RS06870	COG0308	aminopeptidase N
OFY13_RS06885	COG0167	dihydroorotate dehydrogenase activity
OFY13_RS06895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFY13_RS06895	COG0116	Belongs to the methyltransferase superfamily
OFY13_RS06905	COG0488	(ABC) transporter
OFY13_RS06920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OFY13_RS06925	COG1067	ATP-dependent peptidase activity
OFY13_RS06930	COG3120	sequence-specific DNA binding
OFY13_RS06945	COG3064	Membrane
OFY13_RS06945	COG1073	alpha beta
OFY13_RS06945	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
OFY13_RS06950	COG2994	toxin metabolic process
OFY13_RS06975	COG2205	protein histidine kinase activity
OFY13_RS06975	COG0784	Response regulator, receiver
OFY13_RS06990	COG3278	Belongs to the heme-copper respiratory oxidase family
OFY13_RS07005	COG2010	Cytochrome c
OFY13_RS07015	COG2217	Heavy metal translocating P-type atpase
OFY13_RS07030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OFY13_RS07035	COG0589	response to stress
OFY13_RS07040	COG0037	tRNA processing
OFY13_RS07060	COG3842	ATPase activity
OFY13_RS07070	COG1177	transmembrane transport
OFY13_RS07080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFY13_RS07090	COG1115	amino acid carrier protein
OFY13_RS07095	COG1280	lysine exporter protein (LysE YggA)
OFY13_RS07115	COG3501	Rhs element vgr protein
OFY13_RS07125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OFY13_RS07135	COG2814	Major facilitator Superfamily
OFY13_RS07140	COG1566	PFAM secretion protein HlyD family protein
OFY13_RS07145	COG1538	Outer membrane efflux protein
OFY13_RS07155	COG0513	Belongs to the DEAD box helicase family
OFY13_RS07170	COG0840	transmembrane signaling receptor activity
OFY13_RS07170	COG3290	protein histidine kinase activity
OFY13_RS07175	COG0835	chemotaxis
OFY13_RS07180	COG2201	protein-glutamate methylesterase activity
OFY13_RS07190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OFY13_RS07195	COG0784	Response regulator, receiver
OFY13_RS07195	COG0643	Histidine kinase
OFY13_RS07195	COG2198	Histidine kinase
OFY13_RS07200	COG2198	Histidine kinase
OFY13_RS07200	COG0643	Histidine kinase
OFY13_RS07210	COG0745	RESPONSE REGULATOR receiver
OFY13_RS07225	COG0415	Belongs to the DNA photolyase family
OFY13_RS07230	COG0477	Major facilitator Superfamily
OFY13_RS07235	COG0583	DNA-binding transcription factor activity
OFY13_RS07245	COG0095	Lipoate-protein ligase
OFY13_RS07250	COG0443	Heat shock 70 kDa protein
OFY13_RS07260	COG1643	Atp-dependent helicase
OFY13_RS07290	COG0443	Heat shock 70 kDa protein
OFY13_RS07295	COG0443	Heat shock 70 kDa protein
OFY13_RS07300	COG3706	GGDEF domain
OFY13_RS07330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OFY13_RS07335	COG0602	queuosine metabolic process
OFY13_RS07340	COG0561	phosphatase activity
OFY13_RS07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFY13_RS07355	COG4597	amino acid ABC transporter
OFY13_RS07360	COG0765	amino acid transport
OFY13_RS07365	COG1126	abc transporter atp-binding protein
OFY13_RS07370	COG0670	Belongs to the BI1 family
OFY13_RS07375	COG2920	part of a sulfur-relay system
OFY13_RS07380	COG1254	Belongs to the acylphosphatase family
OFY13_RS07385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OFY13_RS07390	COG3706	GGDEF domain
OFY13_RS07400	COG2205	protein histidine kinase activity
OFY13_RS07400	COG3850	Histidine kinase
OFY13_RS07400	COG4999	Histidine kinase
OFY13_RS07400	COG3437	response regulator, receiver
OFY13_RS07405	COG3437	response regulator, receiver
OFY13_RS07410	COG0625	glutathione transferase activity
OFY13_RS07420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
OFY13_RS07430	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFY13_RS07460	COG0372	Belongs to the citrate synthase family
OFY13_RS07465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OFY13_RS07505	COG1129	ABC transporter
OFY13_RS07530	COG0745	RESPONSE REGULATOR receiver
OFY13_RS07535	COG2205	protein histidine kinase activity
OFY13_RS07540	COG3713	MltA-interacting MipA family protein
OFY13_RS07545	COG2990	Protein conserved in bacteria
OFY13_RS07555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFY13_RS07555	COG4191	Histidine kinase
OFY13_RS07560	COG0471	metal ion transport
OFY13_RS07570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OFY13_RS07585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFY13_RS07600	COG3768	UPF0283 membrane protein
OFY13_RS07605	COG3106	COG3106 Predicted ATPase
OFY13_RS07625	COG0494	nUDIX hydrolase
OFY13_RS07630	COG0814	amino acid
OFY13_RS07635	COG1760	l-serine dehydratase
OFY13_RS07640	COG0720	synthase
OFY13_RS07650	COG0017	Asparaginyl-tRNA synthetase
OFY13_RS07655	COG0351	phosphomethylpyrimidine kinase
OFY13_RS07660	COG2770	Histidine kinase
OFY13_RS07660	COG3437	response regulator, receiver
OFY13_RS07665	COG1448	Aminotransferase
OFY13_RS07680	COG0840	transmembrane signaling receptor activity
OFY13_RS07685	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
OFY13_RS07690	COG2943	transferase activity, transferring hexosyl groups
OFY13_RS07695	COG1609	Transcriptional regulator
OFY13_RS07700	COG3394	polysaccharide catabolic process
OFY13_RS07705	COG1486	melibiose metabolic process
OFY13_RS07710	COG1447	Phosphotransferase system cellobiose-specific component IIA
OFY13_RS07720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OFY13_RS07725	COG0726	polysaccharide deacetylase
OFY13_RS07730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OFY13_RS07735	COG1846	Transcriptional regulator
OFY13_RS07760	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFY13_RS07775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OFY13_RS07780	COG3108	Peptidase M15
OFY13_RS07810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OFY13_RS07820	COG2814	Major facilitator Superfamily
OFY13_RS07830	COG1054	Belongs to the UPF0176 family
OFY13_RS07840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OFY13_RS07845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OFY13_RS07850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OFY13_RS07895	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
OFY13_RS07900	COG4139	cobalamin transport
OFY13_RS07920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
OFY13_RS07925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OFY13_RS07930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFY13_RS07935	COG1823	symporter activity
OFY13_RS07940	COG2925	Exonuclease
OFY13_RS07945	COG1380	Effector of murein hydrolase LrgA
OFY13_RS07950	COG1346	cytolysis
OFY13_RS07980	COG0776	regulation of translation
OFY13_RS07985	COG0072	phenylalanine-tRNA ligase activity
OFY13_RS07985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFY13_RS07990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OFY13_RS08035	COG0322	excinuclease ABC activity
OFY13_RS08040	COG2197	response regulator
OFY13_RS08045	COG0417	DNA replication proofreading
OFY13_RS08050	COG5001	Diguanylate cyclase
OFY13_RS08060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OFY13_RS08065	COG3099	Belongs to the UPF0263 family
OFY13_RS08080	COG1228	amidohydrolase
OFY13_RS08085	COG0010	Belongs to the arginase family
OFY13_RS08090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
OFY13_RS08095	COG2986	histidine ammonia-lyase
OFY13_RS08115	COG0247	lactate metabolic process
OFY13_RS08115	COG0277	FAD linked oxidase domain protein
OFY13_RS08130	COG2885	chlorophyll binding
OFY13_RS08150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OFY13_RS08160	COG0281	malic enzyme
OFY13_RS08170	COG2949	membrane
OFY13_RS08180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OFY13_RS08190	COG0492	ferredoxin-NADP+ reductase activity
OFY13_RS08195	COG4988	ABC transporter
OFY13_RS08200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OFY13_RS08205	COG1187	pseudouridine synthase activity
OFY13_RS08210	COG0009	L-threonylcarbamoyladenylate synthase
OFY13_RS08215	COG0613	PHP domain protein
OFY13_RS08225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OFY13_RS08230	COG0512	Glutamine amidotransferase of anthranilate synthase
OFY13_RS08235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OFY13_RS08240	COG0135	phosphoribosylanthranilate isomerase activity
OFY13_RS08240	COG0134	indole-3-glycerol-phosphate synthase activity
OFY13_RS08245	COG0133	tryptophan synthase activity
OFY13_RS08250	COG0159	tryptophan synthase activity
OFY13_RS08260	COG1435	thymidine kinase activity
OFY13_RS08265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OFY13_RS08270	COG1801	Protein of unknown function DUF72
OFY13_RS08275	COG4106	trans-aconitate 2-methyltransferase activity
OFY13_RS08280	COG0500	methyltransferase
OFY13_RS08285	COG4067	protein conserved in archaea
OFY13_RS08285	COG0189	ligase activity
OFY13_RS08300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
OFY13_RS08310	COG3852	Histidine kinase
OFY13_RS08325	COG3070	regulator of competence-specific genes
OFY13_RS08335	COG2431	L-lysine efflux transmembrane transporter activity
OFY13_RS08345	COG0076	glutamate decarboxylase activity
OFY13_RS08350	COG1737	Transcriptional regulator
OFY13_RS08355	COG1454	alcohol dehydrogenase
OFY13_RS08355	COG1012	belongs to the aldehyde dehydrogenase family
OFY13_RS08360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OFY13_RS08365	COG2985	domain, Protein
OFY13_RS08365	COG3273	potassium ion transport
OFY13_RS08370	COG0542	response to heat
OFY13_RS08375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OFY13_RS08380	COG1278	Cold shock
OFY13_RS08390	COG1187	pseudouridine synthase activity
OFY13_RS08395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OFY13_RS08395	COG0140	phosphoribosyl-ATP diphosphatase activity
OFY13_RS08400	COG0107	imidazoleglycerol-phosphate synthase activity
OFY13_RS08405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OFY13_RS08410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OFY13_RS08415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OFY13_RS08415	COG0131	Imidazoleglycerol-phosphate dehydratase
OFY13_RS08420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OFY13_RS08425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OFY13_RS08430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OFY13_RS08435	COG1757	Na H antiporter
OFY13_RS08440	COG2916	Histone family protein nucleoid-structuring protein H-NS
OFY13_RS08445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFY13_RS08450	COG0482	sulfurtransferase activity
OFY13_RS08455	COG2915	High frequency lysogenization protein hflD homolog
OFY13_RS08460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OFY13_RS08470	COG2268	Band 7 protein
OFY13_RS08480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OFY13_RS08495	COG0300	oxidoreductase activity
OFY13_RS08505	COG0501	Belongs to the peptidase M48B family
OFY13_RS08515	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OFY13_RS08520	COG2226	methyltransferase
OFY13_RS08525	COG0156	8-amino-7-oxononanoate synthase activity
OFY13_RS08530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OFY13_RS08535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OFY13_RS08540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OFY13_RS08545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OFY13_RS08550	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OFY13_RS08555	COG0653	protein targeting
OFY13_RS08560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFY13_RS08565	COG2199	diguanylate cyclase activity
OFY13_RS08565	COG2203	Gaf domain
OFY13_RS08575	COG4120	Belongs to the binding-protein-dependent transport system permease family
OFY13_RS08585	COG4628	conserved protein (DUF2132)
OFY13_RS08590	COG3092	negative regulation of chromosome organization
OFY13_RS08595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFY13_RS08600	COG0857	belongs to the CobB CobQ family
OFY13_RS08600	COG0280	phosphate acetyltransferase
OFY13_RS08605	COG0435	Glutathione S-transferase
OFY13_RS08610	COG4608	Belongs to the ABC transporter superfamily
OFY13_RS08615	COG0444	Belongs to the ABC transporter superfamily
OFY13_RS08620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFY13_RS08625	COG0601	transmembrane transport
OFY13_RS08645	COG2204	response regulator
OFY13_RS08650	COG5001	Diguanylate cyclase
OFY13_RS08650	COG3300	MHYT domain
OFY13_RS08655	COG4191	Histidine kinase
OFY13_RS08660	COG5002	protein histidine kinase activity
OFY13_RS08670	COG2201	protein-glutamate methylesterase activity
OFY13_RS08685	COG0009	L-threonylcarbamoyladenylate synthase
OFY13_RS08700	COG1881	PFAM PEBP family protein
OFY13_RS08725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFY13_RS08730	COG0640	Transcriptional regulator
OFY13_RS08755	COG2801	Transposase and inactivated derivatives
OFY13_RS08810	COG0732	type I restriction modification DNA specificity domain
OFY13_RS08835	COG1396	sequence-specific DNA binding
OFY13_RS08860	COG3706	GGDEF domain
OFY13_RS08880	COG1946	Acyl-CoA thioesterase
OFY13_RS08885	COG1522	sequence-specific DNA binding
OFY13_RS08895	COG0616	signal peptide processing
OFY13_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
OFY13_RS08905	COG2983	Belongs to the UPF0260 family
OFY13_RS08915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OFY13_RS08920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OFY13_RS08925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OFY13_RS08930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OFY13_RS08935	COG2832	Protein of unknown function (DUF454)
OFY13_RS08945	COG0745	RESPONSE REGULATOR receiver
OFY13_RS08950	COG0583	DNA-binding transcription factor activity
OFY13_RS08955	COG0778	Nitroreductase
OFY13_RS08960	COG1250	3-hydroxyacyl-CoA dehydrogenase
OFY13_RS08960	COG1024	Enoyl-CoA hydratase
OFY13_RS08965	COG0183	Belongs to the thiolase family
OFY13_RS08980	COG2067	long-chain fatty acid transport protein
OFY13_RS08990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OFY13_RS08995	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
OFY13_RS09000	COG2982	Protein involved in outer membrane biogenesis
OFY13_RS09005	COG0572	uridine kinase
OFY13_RS09010	COG0489	protein tyrosine kinase activity
OFY13_RS09015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFY13_RS09015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OFY13_RS09025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
OFY13_RS09035	COG0617	tRNA 3'-terminal CCA addition
OFY13_RS09035	COG0517	IMP dehydrogenase activity
OFY13_RS09035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OFY13_RS09040	COG2199	diguanylate cyclase activity
OFY13_RS09045	COG0314	molybdopterin synthase activity
OFY13_RS09050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OFY13_RS09055	COG0315	cyclic pyranopterin monophosphate synthase activity
OFY13_RS09060	COG0521	Mo-molybdopterin cofactor biosynthetic process
OFY13_RS09065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OFY13_RS09070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OFY13_RS09075	COG2198	Histidine kinase
OFY13_RS09080	COG2204	response regulator
OFY13_RS09085	COG0556	nucleotide-excision repair
OFY13_RS09095	COG4657	Part of a membrane complex involved in electron transport
OFY13_RS09100	COG2878	Part of a membrane complex involved in electron transport
OFY13_RS09105	COG4656	Part of a membrane complex involved in electron transport
OFY13_RS09110	COG4658	electron transport chain
OFY13_RS09120	COG4660	Part of a membrane complex involved in electron transport
OFY13_RS09125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OFY13_RS09130	COG0346	lactoylglutathione lyase activity
OFY13_RS09155	COG2056	Na+-H+ antiporter family
OFY13_RS09160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OFY13_RS09165	COG1286	toxin biosynthetic process
OFY13_RS09170	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
OFY13_RS09175	COG0285	dihydrofolate synthase activity
OFY13_RS09180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OFY13_RS09185	COG0101	tRNA pseudouridine synthase activity
OFY13_RS09205	COG1263	PTS System
OFY13_RS09205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFY13_RS09205	COG2190	(PTS) system
OFY13_RS09210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OFY13_RS09215	COG1940	carbohydrate kinase activity
OFY13_RS09215	COG1846	Transcriptional regulator
OFY13_RS09220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OFY13_RS09220	COG4651	solute:proton antiporter activity
OFY13_RS09225	COG0367	asparagine synthase
OFY13_RS09240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OFY13_RS09245	COG0563	adenylate kinase activity
OFY13_RS09250	COG0326	Molecular chaperone. Has ATPase activity
OFY13_RS09255	COG3710	Transcriptional regulator
OFY13_RS09275	COG1090	epimerase
OFY13_RS09280	COG0300	oxidoreductase activity
OFY13_RS09285	COG3118	belongs to the thioredoxin family
OFY13_RS09290	COG0330	HflC and HflK could
OFY13_RS09295	COG1585	Membrane protein implicated in regulation of membrane protease activity
OFY13_RS09300	COG0789	Transcriptional regulator
OFY13_RS09315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OFY13_RS09320	COG3115	cell septum assembly
OFY13_RS09325	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
OFY13_RS09330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OFY13_RS09335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFY13_RS09345	COG2190	(PTS) system
OFY13_RS09350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OFY13_RS09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OFY13_RS09360	COG1702	phosphate starvation-inducible protein PhoH
OFY13_RS09370	COG4535	Mg2 and Co2 transporter CorC
OFY13_RS09375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
OFY13_RS09380	COG2888	peptidyl-tyrosine sulfation
OFY13_RS09385	COG0495	leucyl-tRNA aminoacylation
OFY13_RS09390	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
OFY13_RS09395	COG1466	dna polymerase III delta subunit
OFY13_RS09400	COG0799	negative regulation of ribosome biogenesis
OFY13_RS09405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OFY13_RS09410	COG0768	penicillin binding
OFY13_RS09415	COG0772	Belongs to the SEDS family
OFY13_RS09420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OFY13_RS09425	COG1686	Belongs to the peptidase S11 family
OFY13_RS09430	COG2921	Belongs to the UPF0250 family
OFY13_RS09435	COG0321	lipoyl(octanoyl) transferase activity
OFY13_RS09440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OFY13_RS09450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFY13_RS09475	COG1596	polysaccharide export
OFY13_RS09485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OFY13_RS09515	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
OFY13_RS09560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
OFY13_RS09565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OFY13_RS09570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFY13_RS09600	COG0366	Alpha amylase catalytic
OFY13_RS09605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFY13_RS09605	COG1263	PTS System
OFY13_RS09610	COG1609	Transcriptional regulator
OFY13_RS09615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OFY13_RS09620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OFY13_RS09625	COG2011	ABC-type metal ion transport system permease component
OFY13_RS09630	COG1464	Belongs to the NlpA lipoprotein family
OFY13_RS09635	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
OFY13_RS09645	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OFY13_RS09645	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OFY13_RS09660	COG1611	Belongs to the LOG family
OFY13_RS09665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OFY13_RS09670	COG2363	Small membrane protein
OFY13_RS09675	COG0583	DNA-binding transcription factor activity
OFY13_RS09680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OFY13_RS09680	COG0301	tRNA thio-modification
OFY13_RS09690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OFY13_RS09700	COG1722	exodeoxyribonuclease VII activity
OFY13_RS09705	COG0142	geranyltranstransferase activity
OFY13_RS09710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OFY13_RS09715	COG0564	pseudouridine synthase activity
OFY13_RS09720	COG3098	single-species biofilm formation
OFY13_RS09735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFY13_RS09745	COG1671	Belongs to the UPF0178 family
OFY13_RS09750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OFY13_RS09755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OFY13_RS09760	COG0254	rRNA binding
OFY13_RS09765	COG1720	tRNA m6t6A37 methyltransferase activity
OFY13_RS09770	COG0442	prolyl-tRNA aminoacylation
OFY13_RS09790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OFY13_RS09790	COG0047	phosphoribosylformylglycinamidine synthase activity
OFY13_RS09800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OFY13_RS09815	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
OFY13_RS09845	COG0484	heat shock protein binding
OFY13_RS09850	COG0443	Heat shock 70 kDa protein
OFY13_RS09860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OFY13_RS09865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OFY13_RS09870	COG0497	DNA recombination
OFY13_RS09875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFY13_RS09880	COG2914	Belongs to the UPF0125 (RnfH) family
OFY13_RS09885	COG2867	negative regulation of translational initiation
OFY13_RS09890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OFY13_RS09910	COG1061	Type III restriction enzyme res subunit
OFY13_RS09920	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
OFY13_RS09925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OFY13_RS09930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OFY13_RS09950	COG3051	citrate lyase alpha subunit
OFY13_RS09955	COG2301	Belongs to the HpcH HpaI aldolase family
OFY13_RS09960	COG3052	prosthetic group binding
OFY13_RS09965	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
OFY13_RS09975	COG3630	sodium ion export across plasma membrane
OFY13_RS09980	COG0511	ligase activity, forming carbon-carbon bonds
OFY13_RS09980	COG5016	pyruvate
OFY13_RS09985	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
OFY13_RS09995	COG4565	transcriptional regulatory protein
OFY13_RS10010	COG0583	DNA-binding transcription factor activity
OFY13_RS10025	COG2015	COG2015, Alkyl sulfatase and related hydrolases
OFY13_RS10030	COG0583	DNA-binding transcription factor activity
OFY13_RS10040	COG1120	ATPase activity
OFY13_RS10045	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFY13_RS10050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFY13_RS10055	COG4592	Periplasmic binding protein
OFY13_RS10065	COG1028	Short-chain dehydrogenase reductase Sdr
OFY13_RS10070	COG1169	isochorismate synthase
OFY13_RS10075	COG1021	2,3-dihydroxybenzoate-AMP ligase
OFY13_RS10080	COG1535	isochorismatase
OFY13_RS10080	COG3433	isochorismatase activity
OFY13_RS10085	COG1584	GPR1 FUN34 yaaH family protein
OFY13_RS10095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OFY13_RS10095	COG0519	Catalyzes the synthesis of GMP from XMP
OFY13_RS10100	COG0516	GMP reductase activity
OFY13_RS10100	COG0517	IMP dehydrogenase activity
OFY13_RS10105	COG1570	exodeoxyribonuclease VII activity
OFY13_RS10120	COG1160	GTP binding
OFY13_RS10125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFY13_RS10130	COG2976	Protein conserved in bacteria
OFY13_RS10135	COG0124	histidyl-tRNA synthetase
OFY13_RS10140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OFY13_RS10155	COG0105	UTP biosynthetic process
OFY13_RS10160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OFY13_RS10165	COG2975	iron-sulfur cluster assembly
OFY13_RS10170	COG0633	Ferredoxin
OFY13_RS10175	COG0443	Heat shock 70 kDa protein
OFY13_RS10190	COG0822	iron-sulfur transferase activity
OFY13_RS10200	COG1959	2 iron, 2 sulfur cluster binding
OFY13_RS10210	COG0483	inositol monophosphate 1-phosphatase activity
OFY13_RS10215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFY13_RS10220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFY13_RS10225	COG1862	Preprotein translocase
OFY13_RS10235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OFY13_RS10240	COG0517	IMP dehydrogenase activity
OFY13_RS10250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OFY13_RS10255	COG0583	DNA-binding transcription factor activity
OFY13_RS10260	COG0450	alkyl hydroperoxide reductase
OFY13_RS10265	COG3142	Participates in the control of copper homeostasis
OFY13_RS10280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OFY13_RS10285	COG0581	inorganic phosphate transmembrane transporter activity
OFY13_RS10295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OFY13_RS10300	COG0248	Ppx GppA phosphatase
OFY13_RS10310	COG5002	protein histidine kinase activity
OFY13_RS10315	COG0745	RESPONSE REGULATOR receiver
OFY13_RS10325	COG0826	peptidase U32
OFY13_RS10330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFY13_RS10370	COG0542	response to heat
OFY13_RS10375	COG1496	oxidoreductase activity
OFY13_RS10380	COG0564	pseudouridine synthase activity
OFY13_RS10385	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OFY13_RS10390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OFY13_RS10395	COG1605	Chorismate mutase
OFY13_RS10395	COG0077	Prephenate dehydratase
OFY13_RS10400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFY13_RS10405	COG5001	Diguanylate cyclase
OFY13_RS10415	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
OFY13_RS10425	COG0488	(ABC) transporter
OFY13_RS10435	COG0287	Prephenate dehydrogenase
OFY13_RS10435	COG1605	Chorismate mutase
OFY13_RS10440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFY13_RS10445	COG3275	phosphorelay sensor kinase activity
OFY13_RS10450	COG3279	Response regulator of the LytR AlgR family
OFY13_RS10460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OFY13_RS10465	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OFY13_RS10475	COG1966	Carbon starvation protein
OFY13_RS10480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OFY13_RS10485	COG1047	Peptidyl-prolyl cis-trans
OFY13_RS10490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OFY13_RS10500	COG0196	riboflavin kinase activity
OFY13_RS10505	COG0728	peptidoglycan biosynthetic process
OFY13_RS10510	COG0268	Binds directly to 16S ribosomal RNA
OFY13_RS10515	COG0640	Transcriptional regulator
OFY13_RS10520	COG0583	DNA-binding transcription factor activity
OFY13_RS10525	COG1283	sodium-dependent phosphate transmembrane transporter activity
OFY13_RS10535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OFY13_RS10540	COG0730	response to heat
OFY13_RS10545	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
OFY13_RS10550	COG0494	nUDIX hydrolase
OFY13_RS10555	COG3066	DNA modification
OFY13_RS10560	COG0667	Aldo Keto reductase
OFY13_RS10570	COG2204	response regulator
OFY13_RS10575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OFY13_RS10595	COG0513	Belongs to the DEAD box helicase family
OFY13_RS10620	COG3153	acetyltransferase
OFY13_RS10625	COG3154	lipid carrier protein
OFY13_RS10635	COG0826	peptidase U32
OFY13_RS10640	COG0826	peptidase U32
OFY13_RS10660	COG1185	polyribonucleotide nucleotidyltransferase activity
OFY13_RS10665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OFY13_RS10675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OFY13_RS10680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OFY13_RS10685	COG0195	Participates in both transcription termination and antitermination
OFY13_RS10690	COG0779	Required for maturation of 30S ribosomal subunits
OFY13_RS10705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OFY13_RS10715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OFY13_RS10720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OFY13_RS10725	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OFY13_RS10730	COG1534	Rna-binding protein
OFY13_RS10735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFY13_RS10740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
OFY13_RS10745	COG2027	D-alanyl-D-alanine carboxypeptidase
OFY13_RS10750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OFY13_RS10755	COG0739	heme binding
OFY13_RS10770	COG0316	Belongs to the HesB IscA family
OFY13_RS10775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OFY13_RS10780	COG0628	permease
OFY13_RS10785	COG2813	Specifically methylates the guanine in position
OFY13_RS10790	COG0784	Response regulator, receiver
OFY13_RS10790	COG2205	protein histidine kinase activity
OFY13_RS10795	COG0747	negative chemotaxis
OFY13_RS10800	COG0601	transmembrane transport
OFY13_RS10805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFY13_RS10810	COG0444	Belongs to the ABC transporter superfamily
OFY13_RS10815	COG4608	Belongs to the ABC transporter superfamily
OFY13_RS10825	COG2971	BadF BadG BcrA BcrD
OFY13_RS10845	COG3842	ATPase activity
OFY13_RS10855	COG1840	ABC-type Fe3 transport system, periplasmic component
OFY13_RS10860	COG0004	ammonium transporteR
OFY13_RS10865	COG0347	Belongs to the P(II) protein family
OFY13_RS10870	COG3112	Uncharacterised protein family (UPF0231)
OFY13_RS10875	COG1049	propionate catabolic process, 2-methylcitrate cycle
OFY13_RS10880	COG1752	Esterase of the alpha-beta hydrolase superfamily
OFY13_RS10885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OFY13_RS10890	COG1643	Atp-dependent helicase
OFY13_RS10900	COG1489	DNA binding
OFY13_RS10910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OFY13_RS10920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OFY13_RS10925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OFY13_RS10930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OFY13_RS10935	COG0842	Transport permease protein
OFY13_RS10940	COG1131	(ABC) transporter
OFY13_RS10945	COG0659	secondary active sulfate transmembrane transporter activity
OFY13_RS10950	COG0288	reversible hydration of carbon dioxide
OFY13_RS10965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OFY13_RS10970	COG3107	peptidoglycan biosynthetic process
OFY13_RS10975	COG0792	nuclease activity
OFY13_RS10980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OFY13_RS10985	COG2823	Periplasmic or secreted lipoprotein
OFY13_RS10990	COG2969	positive regulation of protein catabolic process
OFY13_RS10995	COG0625	glutathione transferase activity
OFY13_RS11000	COG2857	Cytochrome c1
OFY13_RS11005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OFY13_RS11010	COG0723	plastoquinol--plastocyanin reductase activity
OFY13_RS11015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OFY13_RS11020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OFY13_RS11025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OFY13_RS11035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OFY13_RS11040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OFY13_RS11045	COG0335	large ribosomal subunit rRNA binding
OFY13_RS11050	COG0336	Belongs to the RNA methyltransferase TrmD family
OFY13_RS11055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OFY13_RS11060	COG0228	four-way junction DNA binding
OFY13_RS11065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OFY13_RS11070	COG4137	Cytochrome C assembly protein
OFY13_RS11075	COG4536	flavin adenine dinucleotide binding
OFY13_RS11080	COG1854	S-ribosylhomocysteine lyase activity
OFY13_RS11085	COG2918	glutathione biosynthetic process
OFY13_RS11090	COG0612	Peptidase, M16
OFY13_RS11095	COG1238	metal cluster binding
OFY13_RS11105	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
OFY13_RS11110	COG0511	ligase activity, forming carbon-carbon bonds
OFY13_RS11110	COG5016	pyruvate
OFY13_RS11115	COG3630	sodium ion export across plasma membrane
OFY13_RS11165	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OFY13_RS11170	COG0527	aspartate kinase activity
OFY13_RS11175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OFY13_RS11180	COG2137	regulation of response to DNA damage stimulus
OFY13_RS11185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OFY13_RS11195	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OFY13_RS11200	COG4208	sulfate ABC transporter
OFY13_RS11235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OFY13_RS11240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OFY13_RS11245	COG0585	pseudouridine synthase activity
OFY13_RS11250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OFY13_RS11255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OFY13_RS11260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OFY13_RS11265	COG1968	undecaprenyl-diphosphatase activity
OFY13_RS11270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OFY13_RS11275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OFY13_RS11280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OFY13_RS11290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OFY13_RS11295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OFY13_RS11300	COG1610	YqeY-like protein
OFY13_RS11305	COG0358	DNA primase activity
OFY13_RS11325	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OFY13_RS11330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OFY13_RS11335	COG1349	DNA-binding transcription factor activity
OFY13_RS11360	COG1279	arginine transmembrane transporter activity
OFY13_RS11365	COG0668	transmembrane transport
OFY13_RS11370	COG0191	fructose-bisphosphate aldolase activity
OFY13_RS11375	COG0126	phosphoglycerate kinase activity
OFY13_RS11380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OFY13_RS11385	COG4771	TonB-dependent receptor
OFY13_RS11390	COG0583	DNA-binding transcription factor activity
OFY13_RS11395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OFY13_RS11400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OFY13_RS11410	COG2356	endonuclease I
OFY13_RS11415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OFY13_RS11420	COG0189	ligase activity
OFY13_RS11425	COG1678	Uncharacterized ACR, COG1678
OFY13_RS11430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OFY13_RS11435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OFY13_RS11455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OFY13_RS11460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OFY13_RS11465	COG0762	integral membrane protein
OFY13_RS11480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OFY13_RS11485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OFY13_RS11490	COG2066	Belongs to the glutaminase family
OFY13_RS11495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OFY13_RS11500	COG1194	a g-specific adenine glycosylase
OFY13_RS11505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
OFY13_RS11510	COG0741	lytic transglycosylase activity
OFY13_RS11565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OFY13_RS11570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OFY13_RS11575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFY13_RS11580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OFY13_RS11585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OFY13_RS11590	COG2967	ApaG domain
OFY13_RS11595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OFY13_RS11605	COG3610	response to peptide
OFY13_RS11610	COG2966	Psort location CytoplasmicMembrane, score
OFY13_RS11615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OFY13_RS11620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OFY13_RS11625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OFY13_RS11630	COG0142	geranyltranstransferase activity
OFY13_RS11635	COG0531	amino acid
OFY13_RS11640	COG0039	L-malate dehydrogenase activity
OFY13_RS11645	COG1438	arginine binding
OFY13_RS11650	COG2358	TRAP transporter, solute receptor (TAXI family
OFY13_RS11660	COG0589	response to stress
OFY13_RS11680	COG2235	arginine
OFY13_RS11685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFY13_RS11690	COG1151	hydroxylamine reductase activity
OFY13_RS11695	COG0312	modulator of DNA gyrase
OFY13_RS11700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OFY13_RS11705	COG3164	Protein of unknown function
OFY13_RS11715	COG0424	maF-like protein
OFY13_RS11720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OFY13_RS11725	COG1792	Involved in formation and maintenance of cell shape
OFY13_RS11730	COG1077	Cell shape determining protein MreB Mrl
OFY13_RS11760	COG2165	general secretion pathway protein
OFY13_RS11765	COG2165	general secretion pathway protein
OFY13_RS11775	COG1459	type II secretion system
OFY13_RS11780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OFY13_RS11790	COG3267	Type II secretory pathway component ExeA
OFY13_RS11790	COG3409	Peptidoglycan-binding domain 1 protein
OFY13_RS11815	COG2199	diguanylate cyclase activity
OFY13_RS11815	COG2200	EAL domain
OFY13_RS11820	COG0629	single-stranded DNA binding
OFY13_RS11835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OFY13_RS11845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OFY13_RS11850	COG0527	aspartate kinase activity
OFY13_RS11855	COG0646	methionine synthase
OFY13_RS11855	COG1410	methionine synthase
OFY13_RS11925	COG0175	sulfate reduction
OFY13_RS11935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OFY13_RS11960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFY13_RS11970	COG0653	protein targeting
OFY13_RS12115	COG0735	belongs to the Fur family
OFY13_RS12135	COG0432	Pfam Uncharacterised protein family UPF0047
OFY13_RS12140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OFY13_RS12155	COG0359	binds to the 23S rRNA
OFY13_RS12160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OFY13_RS12165	COG2965	DNA replication, synthesis of RNA primer
OFY13_RS12170	COG0360	Binds together with S18 to 16S ribosomal RNA
OFY13_RS12180	COG2906	2 iron, 2 sulfur cluster binding
OFY13_RS12185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OFY13_RS12190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OFY13_RS12195	COG0049	tRNA binding
OFY13_RS12210	COG2923	Belongs to the DsrF TusC family
OFY13_RS12215	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OFY13_RS12220	COG2964	Protein conserved in bacteria
OFY13_RS12225	COG0545	Peptidyl-prolyl cis-trans isomerase
OFY13_RS12235	COG2900	Belongs to the SlyX family
OFY13_RS12240	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
OFY13_RS12245	COG0330	HflC and HflK could
OFY13_RS12250	COG0330	HflC and HflK could
OFY13_RS12255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OFY13_RS12260	COG1923	regulation of RNA biosynthetic process
OFY13_RS12265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OFY13_RS12270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OFY13_RS12275	COG0860	N-Acetylmuramoyl-L-alanine amidase
OFY13_RS12280	COG0802	atpase or kinase
OFY13_RS12285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OFY13_RS12335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OFY13_RS12340	COG1162	GTPase activity
OFY13_RS12345	COG0688	phosphatidylethanolamine metabolic process
OFY13_RS12350	COG0471	metal ion transport
OFY13_RS12360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OFY13_RS12365	COG4942	peptidase
OFY13_RS12380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OFY13_RS12385	COG2816	NAD+ diphosphatase activity
OFY13_RS12390	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
OFY13_RS12395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OFY13_RS12400	COG0085	RNA polymerase activity
OFY13_RS12405	COG0222	ribosome binding
OFY13_RS12410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OFY13_RS12420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OFY13_RS12425	COG0250	Participates in transcription elongation, termination and antitermination
OFY13_RS12430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OFY13_RS12435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OFY13_RS12460	COG1072	(Pantothenic acid kinase))
OFY13_RS12470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OFY13_RS12480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OFY13_RS12525	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OFY13_RS12540	COG3118	belongs to the thioredoxin family
OFY13_RS12545	COG0513	Belongs to the DEAD box helicase family
OFY13_RS12550	COG0248	Ppx GppA phosphatase
OFY13_RS12555	COG2205	protein histidine kinase activity
OFY13_RS12555	COG0784	Response regulator, receiver
OFY13_RS12560	COG2814	Major facilitator Superfamily
OFY13_RS12575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFY13_RS12580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OFY13_RS12585	COG0511	ligase activity, forming carbon-carbon bonds
OFY13_RS12590	COG0439	Biotin carboxylase
OFY13_RS12595	COG2264	protein methyltransferase activity
OFY13_RS12600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OFY13_RS12605	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
OFY13_RS12640	COG1518	maintenance of DNA repeat elements
OFY13_RS12650	COG1857	crispr-associated protein
OFY13_RS12680	COG1609	Transcriptional regulator
OFY13_RS12685	COG0129	dihydroxy-acid dehydratase activity
OFY13_RS12690	COG3265	gluconokinase activity
OFY13_RS12695	COG2610	gluconate transmembrane transporter activity
OFY13_RS12700	COG0800	Aldolase
OFY13_RS12720	COG0840	transmembrane signaling receptor activity
OFY13_RS12725	COG1982	Orn Lys Arg decarboxylase major
OFY13_RS12730	COG0531	amino acid
OFY13_RS12735	COG3710	Transcriptional regulator
OFY13_RS12740	COG0789	Transcriptional regulator
OFY13_RS12755	COG0151	Belongs to the GarS family
OFY13_RS12765	COG0776	regulation of translation
OFY13_RS12770	COG1253	flavin adenine dinucleotide binding
OFY13_RS12775	COG1940	carbohydrate kinase activity
OFY13_RS12785	COG3068	Protein conserved in bacteria
OFY13_RS12795	COG1573	uracil-dna glycosylase
OFY13_RS12800	COG0668	transmembrane transport
OFY13_RS12805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
OFY13_RS12865	COG1012	belongs to the aldehyde dehydrogenase family
OFY13_RS12865	COG1454	alcohol dehydrogenase
OFY13_RS12900	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
OFY13_RS12905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OFY13_RS12910	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
OFY13_RS12910	COG0662	Cupin 2, conserved barrel domain protein
OFY13_RS12915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OFY13_RS12950	COG1519	Transferase
OFY13_RS12980	COG3642	lipopolysaccharide core region biosynthetic process
OFY13_RS12985	COG0859	PFAM glycosyl transferase family 9
OFY13_RS12990	COG0463	Glycosyl transferase, family 2
OFY13_RS12995	COG0859	PFAM glycosyl transferase family 9
OFY13_RS13000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OFY13_RS13005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OFY13_RS13015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OFY13_RS13020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OFY13_RS13025	COG2003	Belongs to the UPF0758 family
OFY13_RS13035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OFY13_RS13045	COG1309	transcriptional regulator
OFY13_RS13050	COG1560	Kdo2-lipid A biosynthetic process
OFY13_RS13055	COG1560	Kdo2-lipid A biosynthetic process
OFY13_RS13060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OFY13_RS13065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OFY13_RS13070	COG1561	YicC-like family, N-terminal region
OFY13_RS13075	COG2862	Uncharacterized protein family, UPF0114
OFY13_RS13080	COG1263	PTS System
OFY13_RS13080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFY13_RS13085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OFY13_RS13105	COG1120	ATPase activity
OFY13_RS13110	COG4774	siderophore transport
OFY13_RS13115	COG1132	(ABC) transporter
OFY13_RS13130	COG0514	ATP-dependent DNA helicase (RecQ)
OFY13_RS13135	COG2962	Rard protein
OFY13_RS13140	COG0405	Gamma-glutamyltransferase
OFY13_RS13150	COG1280	lysine exporter protein (LysE YggA)
OFY13_RS13155	COG0210	DNA helicase
OFY13_RS13165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OFY13_RS13170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OFY13_RS13210	COG3621	Patatin-like phospholipase
OFY13_RS13240	COG2801	Transposase and inactivated derivatives
OFY13_RS13275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFY13_RS13280	COG0601	transmembrane transport
OFY13_RS13285	COG0747	negative chemotaxis
OFY13_RS13335	COG1309	transcriptional regulator
OFY13_RS13340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OFY13_RS13345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OFY13_RS13350	COG2960	long-chain fatty acid transporting porin activity
OFY13_RS13355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OFY13_RS13360	COG0583	DNA-binding transcription factor activity
OFY13_RS13430	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
OFY13_RS13435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFY13_RS13440	COG1739	Uncharacterized protein family UPF0029
OFY13_RS13445	COG1024	Enoyl-CoA hydratase
OFY13_RS13445	COG1250	3-hydroxyacyl-CoA dehydrogenase
OFY13_RS13450	COG0183	Belongs to the thiolase family
OFY13_RS13455	COG0583	DNA-binding transcription factor activity
OFY13_RS13460	COG2814	Major facilitator Superfamily
OFY13_RS13470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OFY13_RS13475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OFY13_RS13480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OFY13_RS13485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OFY13_RS13490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OFY13_RS13495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OFY13_RS13505	COG0356	it plays a direct role in the translocation of protons across the membrane
OFY13_RS13510	COG3312	ion transport
OFY13_RS13515	COG1475	DNA binding
OFY13_RS13520	COG1192	Involved in chromosome partitioning
OFY13_RS13525	COG0357	Ribosomal RNA small subunit methyltransferase G
OFY13_RS13530	COG0445	tRNA wobble uridine modification
OFY13_RS13535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OFY13_RS13540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OFY13_RS13545	COG0706	membrane insertase activity
OFY13_RS13555	COG0594	ribonuclease P activity
OFY13_RS13560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
OFY13_RS13565	COG1126	abc transporter atp-binding protein
OFY13_RS13585	COG2944	sequence-specific DNA binding
OFY13_RS13590	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
OFY13_RS13625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OFY13_RS13630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OFY13_RS13645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OFY13_RS13655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OFY13_RS13660	COG0509	glycine decarboxylation via glycine cleavage system
OFY13_RS13665	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OFY13_RS13665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OFY13_RS13685	COG1686	Belongs to the peptidase S11 family
OFY13_RS13700	COG2814	Major facilitator Superfamily
OFY13_RS13715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OFY13_RS13740	COG5002	protein histidine kinase activity
OFY13_RS13745	COG0745	RESPONSE REGULATOR receiver
OFY13_RS13765	COG0366	Alpha amylase catalytic
OFY13_RS13800	COG0561	phosphatase activity
OFY13_RS13805	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
OFY13_RS13810	COG3623	hexulose-6-phosphate isomerase
OFY13_RS13820	COG0745	RESPONSE REGULATOR receiver
OFY13_RS13840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OFY13_RS13855	COG2207	Transcriptional regulator
OFY13_RS13860	COG4604	ABC transporter, ATP-binding protein
OFY13_RS13865	COG4605	iron ion homeostasis
OFY13_RS13870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFY13_RS13895	COG5380	lipid catabolic process
OFY13_RS13900	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
OFY13_RS13905	COG0840	transmembrane signaling receptor activity
OFY13_RS13915	COG3240	lipase activity
OFY13_RS13930	COG2814	Major facilitator Superfamily
OFY13_RS13935	COG1757	Na H antiporter
OFY13_RS13945	COG4191	Histidine kinase
OFY13_RS13945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFY13_RS13950	COG0784	Response regulator, receiver
OFY13_RS13950	COG3437	response regulator, receiver
OFY13_RS13955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OFY13_RS13960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OFY13_RS13965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OFY13_RS13970	COG0513	Belongs to the DEAD box helicase family
OFY13_RS13975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OFY13_RS13980	COG0516	GMP reductase activity
OFY13_RS13990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OFY13_RS14000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OFY13_RS14005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OFY13_RS14005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OFY13_RS14030	COG3036	rescue of stalled ribosome
OFY13_RS14035	COG1278	Cold shock
OFY13_RS14040	COG1017	nitric oxide dioxygenase activity
OFY13_RS14040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFY13_RS14045	COG3604	Transcriptional regulator
OFY13_RS14055	COG2195	Cleaves the N-terminal amino acid of tripeptides
OFY13_RS14060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OFY13_RS14075	COG0840	transmembrane signaling receptor activity
OFY13_RS14080	COG0714	Associated with various cellular activities
OFY13_RS14100	COG2304	oxidoreductase activity
OFY13_RS14115	COG1278	Cold shock
OFY13_RS14120	COG5002	protein histidine kinase activity
OFY13_RS14120	COG5001	Diguanylate cyclase
OFY13_RS14130	COG3530	Putative quorum-sensing-regulated virulence factor
OFY13_RS14140	COG0814	amino acid
OFY13_RS14145	COG0589	response to stress
OFY13_RS14155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OFY13_RS14155	COG2111	Na H antiporter
OFY13_RS14160	COG1006	Multisubunit Na H antiporter MnhC subunit
OFY13_RS14165	COG0651	ATP synthesis coupled electron transport
OFY13_RS14170	COG1863	multisubunit Na H antiporter MnhE subunit
OFY13_RS14175	COG2212	antiporter activity
OFY13_RS14180	COG1320	monovalent cation:proton antiporter activity
OFY13_RS14185	COG1017	nitric oxide dioxygenase activity
OFY13_RS14185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OFY13_RS14190	COG0242	peptide deformylase activity
OFY13_RS14200	COG0579	oxidoreductase
OFY13_RS14235	COG2271	Major facilitator Superfamily
OFY13_RS14240	COG0584	glycerophosphoryl diester phosphodiesterase
OFY13_RS14260	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
OFY13_RS14270	COG3447	MASE1 domain protein
OFY13_RS14270	COG5001	Diguanylate cyclase
OFY13_RS14270	COG5002	protein histidine kinase activity
OFY13_RS14275	COG1609	Transcriptional regulator
OFY13_RS14280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFY13_RS14285	COG1879	ABC-type sugar transport system periplasmic component
OFY13_RS14290	COG1172	Belongs to the binding-protein-dependent transport system permease family
OFY13_RS14295	COG1129	ABC transporter
OFY13_RS14300	COG1869	D-ribose catabolic process
OFY13_RS14315	COG3409	Peptidoglycan-binding domain 1 protein
OFY13_RS14315	COG3501	Rhs element vgr protein
OFY13_RS14340	COG3829	transcription factor binding
OFY13_RS14405	COG0564	pseudouridine synthase activity
OFY13_RS14415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFY13_RS14420	COG2771	luxR family
OFY13_RS14420	COG2200	EAL domain
OFY13_RS14430	COG0673	inositol 2-dehydrogenase activity
OFY13_RS14435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OFY13_RS14465	COG1342	Belongs to the UPF0251 family
OFY13_RS14475	COG1301	dicarboxylic acid transport
OFY13_RS14500	COG2814	Major facilitator Superfamily
OFY13_RS14505	COG0583	DNA-binding transcription factor activity
OFY13_RS14510	COG5001	Diguanylate cyclase
OFY13_RS14510	COG3300	MHYT domain
OFY13_RS14515	COG0739	heme binding
OFY13_RS14525	COG0659	secondary active sulfate transmembrane transporter activity
OFY13_RS14530	COG3314	Sporulation integral membrane protein YlbJ
OFY13_RS14550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OFY13_RS14555	COG0581	inorganic phosphate transmembrane transporter activity
OFY13_RS14560	COG0573	inorganic phosphate transmembrane transporter activity
OFY13_RS14565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OFY13_RS14595	COG1770	oligopeptidase
OFY13_RS14600	COG0513	Belongs to the DEAD box helicase family
OFY13_RS14610	COG1388	LysM domain
OFY13_RS14610	COG1376	ErfK ybiS ycfS ynhG family protein
OFY13_RS14615	COG0415	Belongs to the DNA photolyase family
OFY13_RS14625	COG3272	Protein of unknown function (DUF1722)
OFY13_RS14630	COG0813	purine-nucleoside phosphorylase activity
OFY13_RS14655	COG1566	PFAM secretion protein HlyD family protein
OFY13_RS14675	COG0786	glutamate:sodium symporter activity
OFY13_RS14690	COG1999	signal sequence binding
OFY13_RS14700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
OFY13_RS14705	COG0671	phosphoesterase, PA-phosphatase related
OFY13_RS14745	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
OFY13_RS14750	COG0471	metal ion transport
OFY13_RS14780	COG4104	PAAR repeat-containing protein
OFY13_RS14785	COG3501	Rhs element vgr protein
OFY13_RS14795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OFY13_RS14800	COG1640	4-alpha-glucanotransferase
OFY13_RS14805	COG0058	SHG alpha-glucan phosphorylase activity
OFY13_RS14810	COG2909	trisaccharide binding
OFY13_RS14825	COG2084	Dehydrogenase
OFY13_RS14830	COG0217	transcriptional regulatory protein
OFY13_RS14865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OFY13_RS14870	COG1444	tRNA N-acetyltransferase activity
OFY13_RS14905	COG0642	Histidine kinase
OFY13_RS14910	COG2194	sulfuric ester hydrolase activity
OFY13_RS14920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OFY13_RS14925	COG0601	transmembrane transport
OFY13_RS14945	COG0643	Histidine kinase
OFY13_RS14945	COG2198	Histidine kinase
OFY13_RS14950	COG0835	chemotaxis
OFY13_RS14955	COG0835	chemotaxis
OFY13_RS14965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OFY13_RS14990	COG0745	RESPONSE REGULATOR receiver
OFY13_RS15030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OFY13_RS15055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OFY13_RS15085	COG1982	Orn Lys Arg decarboxylase major
OFY13_RS15090	COG0531	amino acid
OFY13_RS15105	COG1901	pseudouridine methyltransferase
OFY13_RS15115	COG4221	oxidoreductase activity
OFY13_RS15120	COG0840	transmembrane signaling receptor activity
OFY13_RS15130	COG2910	NAD(P)H-binding
OFY13_RS15160	COG3722	fumarate hydratase activity
OFY13_RS15165	COG0246	Mannitol dehydrogenase
OFY13_RS15170	COG2213	PTS system mannitol-specific
OFY13_RS15170	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFY13_RS15175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OFY13_RS15180	COG4597	amino acid ABC transporter
OFY13_RS15185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFY13_RS15195	COG1126	abc transporter atp-binding protein
OFY13_RS15200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
OFY13_RS15210	COG0840	transmembrane signaling receptor activity
OFY13_RS15225	COG0840	transmembrane signaling receptor activity
OFY13_RS15240	COG4580	involved in the transport of maltose and maltodextrins
OFY13_RS15255	COG0363	glucosamine-6-phosphate deaminase activity
OFY13_RS15280	COG2259	Doxx family
OFY13_RS15285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OFY13_RS15290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OFY13_RS15300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
OFY13_RS15305	COG3366	ferrous iron transmembrane transporter activity
OFY13_RS15310	COG0700	Nucleoside recognition
OFY13_RS15320	COG0697	spore germination
OFY13_RS15325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
OFY13_RS15330	COG1764	response to oxidative stress
OFY13_RS15335	COG1846	Transcriptional regulator
OFY13_RS15355	COG2207	Transcriptional regulator
OFY13_RS15360	COG1280	lysine exporter protein (LysE YggA)
OFY13_RS15370	COG1902	pentaerythritol trinitrate reductase activity
OFY13_RS15380	COG1132	(ABC) transporter
OFY13_RS15390	COG1902	pentaerythritol trinitrate reductase activity
OFY13_RS15400	COG0583	DNA-binding transcription factor activity
OFY13_RS15405	COG0513	Belongs to the DEAD box helicase family
OFY13_RS15415	COG0840	transmembrane signaling receptor activity
OFY13_RS15425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OFY13_RS15440	COG1620	l-lactate permease
OFY13_RS15450	COG0583	DNA-binding transcription factor activity
OFY13_RS15475	COG4172	Belongs to the ABC transporter superfamily
OFY13_RS15485	COG1067	ATP-dependent peptidase activity
OFY13_RS15490	COG0840	transmembrane signaling receptor activity
OFY13_RS15495	COG2211	Major facilitator Superfamily
OFY13_RS15505	COG3123	guanosine phosphorylase activity
OFY13_RS15510	COG1741	Belongs to the pirin family
OFY13_RS15520	COG5001	Diguanylate cyclase
OFY13_RS15525	COG0583	DNA-binding transcription factor activity
OFY13_RS15560	COG3706	GGDEF domain
OFY13_RS15570	COG0784	Response regulator, receiver
OFY13_RS15570	COG0835	chemotaxis
OFY13_RS15575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OFY13_RS15585	COG0393	Putative heavy-metal-binding
OFY13_RS15600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFY13_RS15605	COG3842	ATPase activity
OFY13_RS15615	COG1175	transmembrane transport
OFY13_RS15620	COG3833	ABC-type maltose transport systems, permease component
OFY13_RS15635	COG1349	DNA-binding transcription factor activity
OFY13_RS15640	COG2199	diguanylate cyclase activity
OFY13_RS15665	COG1278	Cold shock
OFY13_RS15670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OFY13_RS15675	COG2354	Protein conserved in bacteria
OFY13_RS15680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OFY13_RS15690	COG3152	Membrane
OFY13_RS15700	COG0418	dihydroorotase activity
OFY13_RS15705	COG0633	Ferredoxin
OFY13_RS15705	COG3217	Mosc domain protein beta barrel domain protein
OFY13_RS15705	COG0633	Ferredoxin
OFY13_RS15705	COG3217	Mosc domain protein beta barrel domain protein
OFY13_RS15740	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OFY13_RS15745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OFY13_RS15750	COG4558	Periplasmic binding protein
OFY13_RS15755	COG0848	biopolymer transport protein
OFY13_RS15760	COG0811	peptide transport
OFY13_RS15765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
OFY13_RS15775	COG3721	Heme iron utilization protein
OFY13_RS15780	COG0748	coenzyme F420 binding
OFY13_RS15790	COG3835	regulator
OFY13_RS15795	COG2610	gluconate transmembrane transporter activity
OFY13_RS15800	COG1929	Belongs to the glycerate kinase type-1 family
OFY13_RS15825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OFY13_RS15830	COG0363	glucosamine-6-phosphate deaminase activity
OFY13_RS15835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OFY13_RS15840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OFY13_RS15865	COG0346	lactoylglutathione lyase activity
OFY13_RS15875	COG2873	o-acetylhomoserine
OFY13_RS15885	COG1063	alcohol dehydrogenase
OFY13_RS15890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFY13_RS15895	COG0569	domain protein
OFY13_RS15900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OFY13_RS15905	COG0745	RESPONSE REGULATOR receiver
OFY13_RS15910	COG2205	protein histidine kinase activity
OFY13_RS15925	COG0582	viral genome integration into host DNA
OFY13_RS15955	COG1802	Transcriptional regulator
OFY13_RS15955	COG4626	Terminase
OFY13_RS15980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OFY13_RS15985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OFY13_RS16000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OFY13_RS16125	COG0557	exoribonuclease II activity
OFY13_RS16130	COG1278	Cold shock
OFY13_RS16185	COG0582	viral genome integration into host DNA
OFY13_RS16190	COG0583	DNA-binding transcription factor activity
OFY13_RS16195	COG3048	D-serine ammonia-lyase activity
OFY13_RS16210	COG1294	oxidase, subunit
OFY13_RS16215	COG1271	oxidase subunit
OFY13_RS16220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OFY13_RS16225	COG1686	Belongs to the peptidase S11 family
OFY13_RS16235	COG3047	cAMP biosynthetic process
OFY13_RS16245	COG3227	Zinc metalloprotease (Elastase)
OFY13_RS16255	COG2267	carboxylic ester hydrolase activity
OFY13_RS16260	COG2067	long-chain fatty acid transport protein
OFY13_RS16270	COG0366	Alpha amylase catalytic
OFY13_RS16275	COG4989	oxidoreductase activity
OFY13_RS16290	COG1136	(ABC) transporter
OFY13_RS16295	COG1136	(ABC) transporter
OFY13_RS16295	COG0577	efflux transmembrane transporter activity
OFY13_RS16310	COG3275	phosphorelay sensor kinase activity
OFY13_RS16315	COG3279	Response regulator of the LytR AlgR family
OFY13_RS16330	COG0531	amino acid
OFY13_RS16355	COG1765	OsmC-like protein
OFY13_RS16360	COG1253	flavin adenine dinucleotide binding
OFY13_RS16385	COG2264	protein methyltransferase activity
OFY13_RS16400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OFY13_RS16405	COG3186	Phenylalanine-4-hydroxylase
OFY13_RS16410	COG2154	pterin-4-alpha-carbinolamine dehydratase
OFY13_RS16415	COG0456	acetyltransferase
OFY13_RS16420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFY13_RS16425	COG0662	Cupin 2, conserved barrel domain protein
OFY13_RS16430	COG0527	aspartate kinase activity
OFY13_RS16440	COG0459	protein refolding
OFY13_RS16445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OFY13_RS16450	COG2239	Acts as a magnesium transporter
OFY13_RS16460	COG1166	arginine decarboxylase activity
OFY13_RS16465	COG0010	Belongs to the arginase family
OFY13_RS16475	COG3227	Zinc metalloprotease (Elastase)
OFY13_RS16480	COG3397	chitin binding
OFY13_RS16485	COG3046	protein related to deoxyribodipyrimidine photolyase
OFY13_RS16495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OFY13_RS16510	COG0513	Belongs to the DEAD box helicase family
OFY13_RS16520	COG1368	sulfuric ester hydrolase activity
OFY13_RS16525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFY13_RS16540	COG0546	phosphoglycolate phosphatase activity
OFY13_RS16555	COG0484	heat shock protein binding
OFY13_RS16565	COG1716	ATPase activity
OFY13_RS16565	COG5001	Diguanylate cyclase
OFY13_RS16570	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OFY13_RS16580	COG4181	ATPase activity
OFY13_RS16585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OFY13_RS16600	COG1984	allophanate hydrolase subunit 2
OFY13_RS16610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OFY13_RS16615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OFY13_RS16620	COG0840	transmembrane signaling receptor activity
OFY13_RS16625	COG0814	amino acid
OFY13_RS16630	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
OFY13_RS16635	COG0513	Belongs to the DEAD box helicase family
OFY13_RS16640	COG1309	transcriptional regulator
OFY13_RS16650	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
OFY13_RS16655	COG0494	nUDIX hydrolase
OFY13_RS16665	COG2425	protein containing a von Willebrand factor type A (vWA) domain
OFY13_RS16675	COG1126	abc transporter atp-binding protein
OFY13_RS16680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OFY13_RS16685	COG4215	(ABC) transporter
OFY13_RS16690	COG4160	amino acid transport
OFY13_RS16695	COG0583	DNA-binding transcription factor activity
OFY13_RS16725	COG3118	belongs to the thioredoxin family
OFY13_RS16730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OFY13_RS16735	COG0247	lactate metabolic process
OFY13_RS16740	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
OFY13_RS16745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OFY13_RS16750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OFY13_RS16765	COG2926	Belongs to the UPF0265 family
OFY13_RS16780	COG2827	Endonuclease containing a URI domain
OFY13_RS16790	COG1879	ABC-type sugar transport system periplasmic component
OFY13_RS16795	COG5002	protein histidine kinase activity
OFY13_RS16795	COG0784	Response regulator, receiver
OFY13_RS16830	COG1492	cobalamin metabolic process
OFY13_RS16835	COG0725	ABC transporter, periplasmic molybdate-binding protein
OFY13_RS16840	COG4149	molybdate abc transporter
OFY13_RS16845	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OFY13_RS16875	COG1289	transmembrane transporter activity
OFY13_RS16880	COG0210	DNA helicase
OFY13_RS16895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OFY13_RS16900	COG1335	isochorismatase
OFY13_RS16905	COG1803	Methylglyoxal synthase
OFY13_RS16910	COG1879	ABC-type sugar transport system periplasmic component
OFY13_RS16920	COG0469	pyruvate kinase activity
OFY13_RS16925	COG2271	Major facilitator Superfamily
OFY13_RS16935	COG4191	Histidine kinase
OFY13_RS16950	COG1979	alcohol dehydrogenase
OFY13_RS16960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OFY13_RS16980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFY13_RS16985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OFY13_RS16995	COG0183	Belongs to the thiolase family
OFY13_RS17005	COG3243	poly(R)-hydroxyalkanoic acid synthase
OFY13_RS17010	COG3842	ATPase activity
OFY13_RS17020	COG1840	ABC-type Fe3 transport system, periplasmic component
OFY13_RS17025	COG2271	Major facilitator Superfamily
OFY13_RS17030	COG3851	Histidine kinase
OFY13_RS17035	COG2197	response regulator
OFY13_RS17040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OFY13_RS17060	COG0243	molybdopterin cofactor binding
OFY13_RS17070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OFY13_RS17075	COG3850	Histidine kinase
OFY13_RS17080	COG2197	response regulator
OFY13_RS17085	COG1609	Transcriptional regulator
OFY13_RS17105	COG1760	l-serine dehydratase
OFY13_RS17110	COG3069	C4-dicarboxylate transmembrane transporter activity
OFY13_RS17115	COG0840	transmembrane signaling receptor activity
OFY13_RS17120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFY13_RS17125	COG0545	Peptidyl-prolyl cis-trans isomerase
OFY13_RS17130	COG2885	chlorophyll binding
OFY13_RS17140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OFY13_RS17145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OFY13_RS17150	COG1621	beta-fructofuranosidase activity
OFY13_RS17155	COG1609	Transcriptional regulator
OFY13_RS17160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OFY13_RS17160	COG1263	PTS System
OFY13_RS17205	COG0446	pyridine nucleotide-disulphide oxidoreductase
OFY13_RS17240	COG0778	Nitroreductase
OFY13_RS17245	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
OFY13_RS17250	COG0583	DNA-binding transcription factor activity
OFY13_RS17305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OFY13_RS17320	COG2390	Transcriptional regulator
OFY13_RS17325	COG2897	thiosulfate sulfurtransferase activity
OFY13_RS17335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OFY13_RS17345	COG0302	gtp cyclohydrolase
OFY13_RS17350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFY13_RS17350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OFY13_RS17355	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OFY13_RS17360	COG1970	mechanosensitive ion channel activity
OFY13_RS17365	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
OFY13_RS17375	COG1011	Hydrolase
OFY13_RS17380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OFY13_RS17385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OFY13_RS17390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OFY13_RS17395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OFY13_RS17400	COG1840	ABC-type Fe3 transport system, periplasmic component
OFY13_RS17405	COG3842	ATPase activity
OFY13_RS17425	COG3104	oligopeptide transport
OFY13_RS17450	COG4166	transmembrane transport
OFY13_RS17455	COG4174	ABC transporter (Permease)
OFY13_RS17460	COG4239	(ABC) transporter, permease
OFY13_RS17465	COG4172	Belongs to the ABC transporter superfamily
OFY13_RS17470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OFY13_RS17485	COG0625	glutathione transferase activity
OFY13_RS17505	COG2050	protein possibly involved in aromatic compounds catabolism
OFY13_RS17525	COG4771	TonB-dependent receptor
OFY13_RS17525	COG1629	transport
OFY13_RS17530	COG0583	DNA-binding transcription factor activity
OFY13_RS17535	COG0045	succinate-CoA ligase (ADP-forming) activity
OFY13_RS17535	COG1042	CoA-binding domain protein
OFY13_RS17535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFY13_RS17555	COG0023	Translation Initiation Factor
OFY13_RS17625	COG3140	Belongs to the UPF0181 family
OFY13_RS17650	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
OFY13_RS17655	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
OFY13_RS17670	COG3706	GGDEF domain
OFY13_RS17690	COG2199	diguanylate cyclase activity
OFY13_RS17720	COG2824	Alkylphosphonate utilization operon protein PhnA
OFY13_RS17735	COG0737	Belongs to the 5'-nucleotidase family
OFY13_RS17740	COG3593	DNA synthesis involved in DNA repair
OFY13_RS17750	COG0583	DNA-binding transcription factor activity
OFY13_RS17755	COG2116	formate transmembrane transporter activity
OFY13_RS17765	COG3038	cytochrome b561
OFY13_RS17775	COG2200	EAL domain
OFY13_RS17785	COG0586	Pfam SNARE associated Golgi protein
OFY13_RS17790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OFY13_RS17795	COG0745	RESPONSE REGULATOR receiver
OFY13_RS17800	COG2205	protein histidine kinase activity
OFY13_RS17805	COG0674	pyruvate-flavodoxin oxidoreductase activity
OFY13_RS17805	COG1013	pyruvate-flavodoxin oxidoreductase activity
OFY13_RS17805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
OFY13_RS17805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OFY13_RS17810	COG3158	transport of potassium into the cell
OFY13_RS17820	COG0523	cobalamin synthesis protein
OFY13_RS17825	COG0038	chloride channel
OFY13_RS17835	COG0156	8-amino-7-oxononanoate synthase activity
OFY13_RS17840	COG2205	protein histidine kinase activity
OFY13_RS17840	COG0784	Response regulator, receiver
OFY13_RS17845	COG0419	ATPase involved in DNA repair
OFY13_RS17850	COG0420	3'-5' exonuclease activity
OFY13_RS17855	COG1609	Transcriptional regulator
OFY13_RS17860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFY13_RS17860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OFY13_RS17865	COG1105	Belongs to the carbohydrate kinase PfkB family
OFY13_RS17870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFY13_RS17870	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
OFY13_RS17870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OFY13_RS17875	COG4067	protein conserved in archaea
OFY13_RS17875	COG0189	ligase activity
OFY13_RS17885	COG0602	queuosine metabolic process
OFY13_RS17890	COG1328	CTP reductase activity
OFY13_RS17905	COG0346	lactoylglutathione lyase activity
OFY13_RS17950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFY13_RS18195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFY13_RS18225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OFY13_RS18245	COG0494	nUDIX hydrolase
OFY13_RS18350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins