locus-tag class description GPY07_RS00005 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY07_RS00010 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY07_RS00015 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY07_RS00020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY07_RS00025 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY07_RS00035 ENOG4107QZV Type I secretion membrane fusion protein GPY07_RS00050 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GPY07_RS00055 ENOG4105CS2 ec 3.2.1.21 GPY07_RS00060 ENOG4105DDV Transcriptional regulator (LacI family GPY07_RS00065 ENOG4105M4H endoribonuclease L-psp GPY07_RS00070 ENOG4105XEP YhcH YjgK YiaL family protein GPY07_RS00075 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GPY07_RS00080 ENOG4105E98 transcriptional regulator DeoR family GPY07_RS00085 ENOG4108IJ9 (ABC) transporter GPY07_RS00090 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GPY07_RS00120 ENOG4109015 Biopolymer transport protein exbD tolR GPY07_RS00125 ENOG41067XB TonB family GPY07_RS00145 ENOG4107QI1 Mate efflux family protein GPY07_RS00155 ENOG4105FGM Fructosamine kinase GPY07_RS00165 ENOG4107TT5 NLP P60 protein GPY07_RS00170 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS00180 ENOG4106IUH DTW domain containing protein GPY07_RS00185 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GPY07_RS00210 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY07_RS00215 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GPY07_RS00220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS00225 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component GPY07_RS00235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS00240 ENOG4105BZU Histidine kinase GPY07_RS00245 ENOG4105C5H ABC transporter GPY07_RS00250 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GPY07_RS00270 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPY07_RS00280 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPY07_RS00285 ENOG4105QAX Iron-sulfur GPY07_RS00300 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GPY07_RS00310 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY07_RS00325 ENOG4105QNR S1 RNA binding domain protein GPY07_RS00330 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY07_RS00335 ENOG4105DY2 Paraquat-inducible protein b GPY07_RS00340 ENOG4105H2K paraquat-inducible protein a GPY07_RS00345 ENOG4105BZ1 (ABC) transporter GPY07_RS00350 ENOG4108ZGC gaf domain protein GPY07_RS00355 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GPY07_RS00360 ENOG4105CN1 protease GPY07_RS00370 ENOG4105CD8 aminopeptidase N GPY07_RS00380 ENOG4105C7I Dehydrogenase GPY07_RS00385 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GPY07_RS00390 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GPY07_RS00395 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GPY07_RS00405 ENOG4105C5H ABC transporter GPY07_RS00420 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GPY07_RS00425 ENOG4105DAN ATP-dependent protease GPY07_RS00430 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GPY07_RS00510 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR GPY07_RS00540 ENOG4105MQ5 zona occludens toxin GPY07_RS00545 ENOG4107927 Cholera enterotoxin, A subunit GPY07_RS00555 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR GPY07_RS00575 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR GPY07_RS00605 ENOG4105MQ5 zona occludens toxin GPY07_RS00610 ENOG4107927 Cholera enterotoxin, A subunit GPY07_RS00620 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR GPY07_RS00640 ENOG4105EUK rtx toxin RtxA GPY07_RS00645 ENOG4108RC6 RTX toxin GPY07_RS00670 ENOG4105BZU Histidine kinase GPY07_RS00685 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GPY07_RS00700 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) GPY07_RS00710 ENOG4105C59 p-type ATPase GPY07_RS00725 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPY07_RS00730 ENOG4105Q9Y Universal stress protein GPY07_RS00735 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GPY07_RS00755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS00760 ENOG4105F38 ABC transporter, permease GPY07_RS00765 ENOG4105D38 putrescine abc transporter GPY07_RS00770 ENOG4107RUE extracellular solute-binding protein family 1 GPY07_RS00775 ENOG4107RUE extracellular solute-binding protein family 1 GPY07_RS00790 ENOG4105BZG amino acid carrier protein GPY07_RS00795 ENOG410829K Lysine exporter protein (Lyse ygga) GPY07_RS00820 ENOG4105CS6 Rhs element vgr protein GPY07_RS00825 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY07_RS00830 ENOG4105CTD carboxy-peptidase GPY07_RS00835 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS00840 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY07_RS00845 ENOG4105CW7 secretion protein, HlyD family GPY07_RS00850 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GPY07_RS00860 ENOG4105C1J atp-dependent rna helicase GPY07_RS00865 ENOG4107SDU Methyl-accepting chemotaxis GPY07_RS00870 ENOG4108N3W hemolysin secretion protein GPY07_RS00875 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS00880 ENOG4108V3W Chemotaxis protein, CheW GPY07_RS00885 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY07_RS00895 ENOG4105BZU Histidine kinase GPY07_RS00900 ENOG4105CBS Chea signal transduction histidine kinase GPY07_RS00905 ENOG4105CBS Chea signal transduction histidine kinase GPY07_RS00915 ENOG4108VYJ response regulator receiver protein GPY07_RS00920 ENOG4108NVR Methyl-accepting chemotaxis GPY07_RS00925 ENOG4105KPY Small multidrug resistance protein GPY07_RS00930 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY07_RS00935 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY07_RS00940 ENOG4105EJC lysr family transcriptional regulator GPY07_RS00950 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GPY07_RS00955 ENOG4105R8A Heat shock protein GPY07_RS00965 ENOG4105CQ7 ATP-dependent helicase GPY07_RS00990 ENOG4105BZU Histidine kinase GPY07_RS01000 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY07_RS01005 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY07_RS01010 ENOG4105BZU Histidine kinase GPY07_RS01020 ENOG4105BZU Histidine kinase GPY07_RS01040 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GPY07_RS01045 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GPY07_RS01050 ENOG410667J hydrolase GPY07_RS01060 ENOG4107QXX ABC transporter GPY07_RS01065 ENOG4105EZ7 amino acid ABC transporter GPY07_RS01070 ENOG4105DRP amino acid AbC transporter GPY07_RS01075 ENOG4105CDA abc transporter atp-binding protein GPY07_RS01080 ENOG4108MN8 Membrane GPY07_RS01085 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GPY07_RS01090 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GPY07_RS01095 ENOG4105DR4 Methyltransferase GPY07_RS01100 ENOG4106TD9 Diguanylate cyclase GPY07_RS01110 ENOG4105BZU Histidine kinase GPY07_RS01115 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY07_RS01120 ENOG4108RXX maleylacetoacetate isomerase GPY07_RS01130 ENOG4105F1J Homogentisate 1,2-dioxygenase GPY07_RS01135 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GPY07_RS01140 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY07_RS01155 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY07_RS01165 ENOG4108I0Z Aconitate hydratase GPY07_RS01170 ENOG4105BZN citrate synthase GPY07_RS01175 ENOG4105CR4 methylisocitrate lyase GPY07_RS01180 ENOG41073TP transcriptional regulator GPY07_RS01210 ENOG4107SDZ Galactoside transport system permease protein mglC GPY07_RS01215 ENOG4105C2J ABC transporter GPY07_RS01240 ENOG4107EXC regulatoR GPY07_RS01245 ENOG4105EB3 Histidine kinase GPY07_RS01250 ENOG4105RW8 MltA-interacting MipA family protein GPY07_RS01255 ENOG4108MJ5 VirK protein GPY07_RS01260 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS01265 ENOG4105BZU Histidine kinase GPY07_RS01270 ENOG4105C8P )-transporter GPY07_RS01275 ENOG4108NVR Methyl-accepting chemotaxis GPY07_RS01280 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY07_RS01295 ENOG4105D9U N-acetyltransferase GPY07_RS01300 ENOG4108JU8 Transcriptional regulator GPY07_RS01310 ENOG4105CM6 amino acid regulated cytosolic protein GPY07_RS01325 ENOG4105CRQ synthase (Component I) GPY07_RS01330 ENOG4105P8F nudix hydrolase GPY07_RS01335 ENOG4105C44 Serine transporter GPY07_RS01340 ENOG4105EJQ L-serine dehydratase GPY07_RS01345 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GPY07_RS01350 ENOG4108NVR Methyl-accepting chemotaxis GPY07_RS01355 ENOG4105C5S asparaginyl-tRNA synthetase GPY07_RS01365 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY07_RS01375 ENOG4105CGF Aromatic amino acid aminotransferase GPY07_RS01390 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS01395 ENOG4105DJ9 glucan biosynthesis protein GPY07_RS01400 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) GPY07_RS01405 ENOG41060NJ transcriptional regulator GPY07_RS01410 ENOG410901P UPF0249 protein GPY07_RS01415 ENOG4105F8D glycoside hydrolase family 4 GPY07_RS01420 ENOG4105VCP PTS System GPY07_RS01430 ENOG4105VZJ PTS System GPY07_RS01440 ENOG4105C94 Transporter GPY07_RS01445 ENOG41067TZ transcriptional regulator, MarR family GPY07_RS01460 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY07_RS01470 ENOG4105CH5 extracellular solute-binding protein, family 7 GPY07_RS01485 ENOG4105C5X domain protein GPY07_RS01490 ENOG4105EAQ (twin-arginine translocation) pathway signal GPY07_RS01495 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GPY07_RS01520 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GPY07_RS01530 ENOG4105S8Q sugar efflux transporter GPY07_RS01540 ENOG4105C72 UPF0176 protein GPY07_RS01545 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY07_RS01550 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY07_RS01555 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY07_RS01560 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY07_RS01565 ENOG4107QK7 reductase GPY07_RS01590 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS01605 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS01610 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) GPY07_RS01625 ENOG4108YZT Adenosylcobinamide kinase GPY07_RS01630 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GPY07_RS01635 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GPY07_RS01640 ENOG4105E0X reductase GPY07_RS01645 ENOG4108ETY sodium dicarboxylate symporter GPY07_RS01650 ENOG4105CJB Exodeoxyribonuclease I GPY07_RS01660 ENOG41067MG lrgb family GPY07_RS01665 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GPY07_RS01685 ENOG4105FQ6 thiopurine methyltransferase GPY07_RS01700 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY07_RS01705 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GPY07_RS01710 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GPY07_RS01720 ENOG4105BZU Histidine kinase GPY07_RS01750 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GPY07_RS01755 ENOG4105WH1 Two component transcriptional regulator luxr family GPY07_RS01760 ENOG4105CQ2 DNA polymerase GPY07_RS01765 ENOG4105BZU Histidine kinase GPY07_RS01775 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY07_RS01790 ENOG4105CZE histidine utilization repressor GPY07_RS01795 ENOG4105CI2 imidazolone-5-propionate hydrolase GPY07_RS01800 ENOG41088SP formiminoglutamate hydrolase GPY07_RS01805 ENOG4105CGP Urocanate hydratase GPY07_RS01810 ENOG4105C84 Histidine ammonia-lyase GPY07_RS01820 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GPY07_RS01830 ENOG4105CQB FAD linked oxidase domain protein GPY07_RS01845 ENOG4108ZG0 Ompa motb domain protein GPY07_RS01865 ENOG4105C8V SAICAR synthetase GPY07_RS01875 ENOG4107R1I NAD-dependent malic enzyme GPY07_RS01885 ENOG4107GZ4 SanA protein GPY07_RS01890 ENOG4105BZU Histidine kinase GPY07_RS01895 ENOG4105C9B Cysteine desulfurase GPY07_RS01905 ENOG4105C3M thioredoxin reductase GPY07_RS01910 ENOG4108JJ9 ABC, transporter GPY07_RS01915 ENOG4108JJ8 (ABC) transporter GPY07_RS01920 ENOG4105FE9 pseudouridine synthase GPY07_RS01925 ENOG4107RTD sua5 ycio yrdc ywlc family protein GPY07_RS01930 ENOG4105DB7 PHP domain protein GPY07_RS01940 ENOG4105CRQ synthase (Component I) GPY07_RS01945 ENOG4105DDQ anthranilate synthase GPY07_RS01950 ENOG4108I0Q anthranilate phosphoribosyltransferase GPY07_RS01955 ENOG4105DK0 Indole-3-glycerol phosphate synthase GPY07_RS01960 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPY07_RS01965 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GPY07_RS01970 ENOG4105CK2 sodium dicarboxylate symporter GPY07_RS01975 ENOG4107104 thymidine kinase GPY07_RS01980 ENOG4105C9M aspartyl-trna synthetase GPY07_RS01985 ENOG41081XQ Conserved Protein GPY07_RS01990 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GPY07_RS01995 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GPY07_RS02000 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY07_RS02015 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GPY07_RS02025 ENOG4105CUX Signal transduction histidine kinase GPY07_RS02050 ENOG4105DWU Membrane GPY07_RS02060 ENOG4105DY8 decarboxylase GPY07_RS02065 ENOG4106KNT transcriptional regulator GPY07_RS02075 ENOG41090BQ Glutaredoxin GPY07_RS02085 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY07_RS02090 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GPY07_RS02095 ENOG4105VEQ Cold shock protein GPY07_RS02105 ENOG4108R99 pseudouridine synthase GPY07_RS02110 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GPY07_RS02115 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GPY07_RS02120 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GPY07_RS02125 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GPY07_RS02130 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GPY07_RS02135 ENOG4105CIH Imidazole acetol-phosphate transaminase GPY07_RS02140 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GPY07_RS02145 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GPY07_RS02150 ENOG4107S6Z Na H antiporter GPY07_RS02160 ENOG4107RE1 Inosine-guanosine kinase GPY07_RS02165 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GPY07_RS02170 ENOG41075W9 High frequency lysogenization protein HflD homolog GPY07_RS02175 ENOG4107QTF adenylosuccinate lyase GPY07_RS02185 ENOG4105RHG GPY07_RS02195 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GPY07_RS02210 ENOG4107FW0 short-chain dehydrogenase reductase GPY07_RS02220 ENOG4105D0M Protease HtpX homolog GPY07_RS02230 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GPY07_RS02235 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GPY07_RS02240 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY07_RS02245 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GPY07_RS02250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GPY07_RS02255 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GPY07_RS02260 ENOG4105D1H recombination factor protein RarA GPY07_RS02270 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GPY07_RS02275 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GPY07_RS02280 ENOG4105BZU Histidine kinase GPY07_RS02285 ENOG4108JJB ABC transporter GPY07_RS02290 ENOG4105C7J ABC transporter, permease GPY07_RS02300 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY07_RS02305 ENOG4105PQ6 UPF0208 membrane protein GPY07_RS02310 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY07_RS02315 ENOG4108DNC Involved in acetate metabolism (By similarity) GPY07_RS02320 ENOG4105CHF Glutathione S-transferase GPY07_RS02325 ENOG4108JQ7 (ABC) transporter GPY07_RS02330 ENOG4105C3U ABC transporter GPY07_RS02335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY07_RS02340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY07_RS02345 ENOG4107QSI ABC, transporter GPY07_RS02360 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS02365 ENOG4105BZU Histidine kinase GPY07_RS02370 ENOG4105BZU Histidine kinase GPY07_RS02375 ENOG4105BZU Histidine kinase GPY07_RS02385 ENOG4107YTP response regulator receiver protein GPY07_RS02400 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY07_RS02420 ENOG4108V1U phospholipid-binding protein GPY07_RS02445 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY07_RS02450 ENOG41082YX Transcriptional regulator, arsr family GPY07_RS02460 ENOG4105BZU Histidine kinase GPY07_RS02480 ENOG4105C29 acyl-CoA thioesterase GPY07_RS02485 ENOG4108XM1 transcriptional regulator AsnC family GPY07_RS02495 ENOG4105ERU peptidase GPY07_RS02500 ENOG4105UBK short-chain dehydrogenase reductase GPY07_RS02510 ENOG4105KRS Proteinase inhibitor GPY07_RS02515 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GPY07_RS02520 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GPY07_RS02525 ENOG4107QMP dna polymerase iii subunits gamma and tau GPY07_RS02530 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GPY07_RS02535 ENOG4105WD1 Membrane GPY07_RS02545 ENOG4105I93 response regulator GPY07_RS02550 ENOG4105EJC lysr family transcriptional regulator GPY07_RS02555 ENOG41069NU Nitroreductase GPY07_RS02560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY07_RS02565 ENOG4105CHU acetyl-coa acetyltransferase GPY07_RS02585 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY07_RS02595 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GPY07_RS02600 ENOG4108GAE asmA family GPY07_RS02605 ENOG4105DBI uridine monophosphokinase GPY07_RS02610 ENOG4105D1F ATP-binding protein GPY07_RS02615 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GPY07_RS02625 ENOG4108I5U Uridine phosphorylase GPY07_RS02640 ENOG4105BZU Histidine kinase GPY07_RS02645 ENOG4108ZAF Molybdopterin GPY07_RS02650 ENOG4105M00 molybdopterin converting factor, subunit 1 GPY07_RS02655 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY07_RS02660 ENOG4108RIR Molybdenum cofactor biosynthesis protein GPY07_RS02665 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY07_RS02670 ENOG4105CHW UPF0052 protein GPY07_RS02680 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS02685 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GPY07_RS02700 ENOG4108R3D Electron transport complex GPY07_RS02710 ENOG4105D6A Electron transport complex GPY07_RS02715 ENOG4108UQQ Electron transport complex GPY07_RS02720 ENOG4105DZB Electron transport complex GPY07_RS02725 ENOG4105CSM endonuclease III GPY07_RS02730 ENOG4108UYE Lactoylglutathione lyase GPY07_RS02735 ENOG4106WH9 Protein of unknown function (DUF2753) GPY07_RS02740 ENOG4105EIY sodium-type flagellar protein motY GPY07_RS02745 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GPY07_RS02750 ENOG4105D3Y Na H antiporter GPY07_RS02755 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GPY07_RS02760 ENOG4105E96 Colicin v production protein GPY07_RS02765 ENOG4108S3P Sporulation domain protein GPY07_RS02770 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GPY07_RS02775 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GPY07_RS02780 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GPY07_RS02790 ENOG4105CX6 glutaminyL-tRNA synthetase GPY07_RS02795 ENOG4105CI1 PTS System GPY07_RS02800 ENOG4105CE4 GlcNAc 6-P deacetylase GPY07_RS02805 ENOG4105E2R ROK family GPY07_RS02810 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPY07_RS02815 ENOG4105CAQ asparagine synthetase GPY07_RS02820 ENOG4105MDZ Transcriptional activator rfaH GPY07_RS02825 ENOG4105DUX Transporter GPY07_RS02830 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GPY07_RS02835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GPY07_RS02840 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GPY07_RS02845 ENOG4108TU9 TRANSCRIPTIONal GPY07_RS02860 ENOG4108RE9 Phosphodiesterase GPY07_RS02865 ENOG4105ECP epimerase GPY07_RS02870 ENOG4105E1F short-chain dehydrogenase reductase GPY07_RS02880 ENOG4107QR8 Thioredoxin GPY07_RS02885 ENOG4107QX8 SPFH domain, Band 7 family protein GPY07_RS02890 ENOG4105G5H Membrane GPY07_RS02895 ENOG4108Z6Z Transcriptional regulator GPY07_RS02905 ENOG41081QG Porin Gram-negative type GPY07_RS02910 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GPY07_RS02915 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GPY07_RS02920 ENOG4105EXN Sulfate transport protein CysZ GPY07_RS02925 ENOG4105C6T cysteine synthase GPY07_RS02935 ENOG4105KZ7 phosphocarrier protein hpr GPY07_RS02945 ENOG4105C5Y PTS System GPY07_RS02950 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY07_RS02955 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GPY07_RS02960 ENOG4105C9A Phoh family GPY07_RS02965 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GPY07_RS02970 ENOG4108JU5 Magnesium and cobalt efflux protein GPY07_RS02975 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GPY07_RS02980 ENOG4107PAI alpha helical protein GPY07_RS02985 ENOG4105C8T Leucyl-tRNA synthetase GPY07_RS02990 ENOG4108U2H Rare lipoprotein B GPY07_RS02995 ENOG4105DJF DNA polymerase III, delta' subunit GPY07_RS03000 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GPY07_RS03005 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GPY07_RS03010 ENOG4105CJN penicillin-binding protein GPY07_RS03015 ENOG4105CNI cell division protein FtsW GPY07_RS03020 ENOG4105K6T rare lipoprotein A GPY07_RS03025 ENOG4105DZ1 carboxypeptidase GPY07_RS03030 ENOG4108Z43 UPF0250 protein GPY07_RS03035 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GPY07_RS03040 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GPY07_RS03050 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY07_RS03070 ENOG4105D75 Capsular exopolysaccharide family GPY07_RS03075 ENOG4105DAY polysaccharide export protein GPY07_RS03085 ENOG4105D3Q Sugar transferase GPY07_RS03100 ENOG4108MA4 Peptidase M66 GPY07_RS03115 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family GPY07_RS03125 ENOG4105Q84 sucrose synthase GPY07_RS03135 ENOG4105D7W serine acetyltransferase GPY07_RS03155 ENOG4108UW5 maltose o-acetyltransferase GPY07_RS03165 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GPY07_RS03170 ENOG4107ZF2 Phosphatase GPY07_RS03205 ENOG4105CG3 alpha amylase, catalytic region GPY07_RS03210 ENOG4105C5Y PTS System GPY07_RS03215 ENOG4105D4X repressor GPY07_RS03220 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GPY07_RS03225 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS03230 ENOG4108UMI ABC transporter, permease GPY07_RS03235 ENOG4105D01 (LipO)protein GPY07_RS03240 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein GPY07_RS03245 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GPY07_RS03250 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GPY07_RS03260 ENOG4105BZU Histidine kinase GPY07_RS03270 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GPY07_RS03275 ENOG4105M08 Membrane GPY07_RS03280 ENOG4105ETT transcriptional Regulator, LysR family GPY07_RS03285 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GPY07_RS03290 ENOG4106VK6 Flagellar motor protein GPY07_RS03295 ENOG4105E14 MotA TolQ exbB proton channel GPY07_RS03305 ENOG4105CTB Polyprenyl synthetase GPY07_RS03310 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GPY07_RS03315 ENOG4105DR9 pseudouridine synthase GPY07_RS03320 ENOG4105WP7 tRNA pseudouridine synthase C GPY07_RS03335 ENOG4108428 Inherit from COG: -acetyltransferase GPY07_RS03345 ENOG4108UPT UPF0178 protein GPY07_RS03350 ENOG4105CFC Transporter GPY07_RS03360 ENOG4105NRA 50s ribosomal protein l31 type b GPY07_RS03365 ENOG4108R96 Methyltransferase, YaeB family GPY07_RS03370 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GPY07_RS03390 ENOG4108RS6 transposase GPY07_RS03395 ENOG4107QIK phosphoribosylformylglycinamidine synthase GPY07_RS03405 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GPY07_RS03410 ENOG4108Z6B deaminase GPY07_RS03415 ENOG4105CFC Transporter GPY07_RS03440 ENOG4106855 Competence protein GPY07_RS03450 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY07_RS03455 ENOG4105CFG Acts as a chaperone (By similarity) GPY07_RS03460 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GPY07_RS03465 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GPY07_RS03470 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GPY07_RS03475 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY07_RS03480 ENOG4105VDB UPF0125 protein GPY07_RS03485 ENOG4108Z1B Cyclase dehydrase GPY07_RS03490 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GPY07_RS03500 ENOG4105DFP Integrase GPY07_RS03510 ENOG4105DFP Integrase GPY07_RS03515 ENOG4105F88 accessory colonization factor AcfD GPY07_RS03525 ENOG4105DR5 peptidase GPY07_RS03540 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS03545 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GPY07_RS03560 ENOG4108VEY type ii secretion system GPY07_RS03565 ENOG4107QHF type ii secretion system protein e GPY07_RS03600 ENOG4105XB6 Toxin coregulated pilin GPY07_RS03615 ENOG4107RK6 Methyl-accepting chemotaxis GPY07_RS03620 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GPY07_RS03640 ENOG4105C26 Dehydrogenase GPY07_RS03705 ENOG4105DZ0 fad dependent oxidoreductase GPY07_RS03710 ENOG4108Z4U Ferredoxin GPY07_RS03725 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GPY07_RS03730 ENOG4105YGP holo-ACP synthase CitX GPY07_RS03735 ENOG4105CHY citrate lyase, alpha GPY07_RS03740 ENOG4105CI0 Citrate lyase GPY07_RS03745 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) GPY07_RS03750 ENOG4105DUA (citrate (pro-3S)-lyase ligase GPY07_RS03765 ENOG4107QSA Oxaloacetate decarboxylase GPY07_RS03770 ENOG4105D9Q decarboxylase (Beta subunit) GPY07_RS03775 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY07_RS03780 ENOG4106YYS transcriptional regulatory protein GPY07_RS03800 ENOG4105MWK D-amino acid dehydrogenase, small subunit GPY07_RS03805 ENOG4105BZG amino acid carrier protein GPY07_RS03810 ENOG4105EUZ Beta-lactamase domain protein GPY07_RS03815 ENOG41064T2 transcriptional regulator, lysR family GPY07_RS03825 ENOG4105E0A ABC, transporter GPY07_RS03835 ENOG4105DQ5 transport system permease protein GPY07_RS03840 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GPY07_RS03850 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GPY07_RS03855 ENOG4105E4F Isochorismate synthase GPY07_RS03860 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GPY07_RS03865 ENOG4105WQI isochorismatase GPY07_RS03870 ENOG4106HK8 GPR1 FUN34 yaaH family protein GPY07_RS03880 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GPY07_RS03885 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY07_RS03890 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY07_RS03905 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GPY07_RS03910 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY07_RS03915 ENOG4105N21 Membrane GPY07_RS03920 ENOG4105CUT histidyl-tRNA synthetase GPY07_RS03925 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GPY07_RS03935 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GPY07_RS03940 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GPY07_RS03945 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY07_RS03950 ENOG4105WVQ Fe-S assembly protein IscX GPY07_RS03955 ENOG4108ZIT Ferredoxin, 2FE-2S GPY07_RS03960 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY07_RS03965 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) GPY07_RS03970 ENOG4108Z4V iron-sulfur cluster assembly GPY07_RS03975 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GPY07_RS03980 ENOG4105C3J Cysteine desulfurase GPY07_RS03985 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GPY07_RS03990 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GPY07_RS03995 ENOG4105ECY inositol monophosphatase GPY07_RS04000 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY07_RS04005 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY07_RS04010 ENOG4105VIE preprotein translocase, subunit YajC GPY07_RS04015 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GPY07_RS04020 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GPY07_RS04025 ENOG4105W87 Cbs domain GPY07_RS04030 ENOG4108I9X Isocitrate lyase GPY07_RS04035 ENOG4107QP3 malate synthase g GPY07_RS04040 ENOG4105C5Q Transcriptional regulator GPY07_RS04045 ENOG4105D3R alkyl hydroperoxide reductase GPY07_RS04050 ENOG4106N3A copper homeostasis protein cutc GPY07_RS04055 ENOG4105CSR polyphosphate kinase 2 GPY07_RS04065 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS04070 ENOG4105E2Z phosphate ABC transporter (Permease GPY07_RS04075 ENOG4105C8U phosphate abc transporter GPY07_RS04080 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GPY07_RS04085 ENOG4105C9X ppx gppa phosphatase GPY07_RS04095 ENOG4105BZU Histidine kinase GPY07_RS04100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY07_RS04105 ENOG4105DH7 May be involved in recombination (By similarity) GPY07_RS04110 ENOG4105CFP Peptidase U32 GPY07_RS04115 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GPY07_RS04155 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY07_RS04160 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GPY07_RS04165 ENOG4105C34 Pseudouridine synthase GPY07_RS04170 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GPY07_RS04175 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GPY07_RS04185 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein GPY07_RS04190 ENOG4108K0B C-di-gmp phosphodiesterase GPY07_RS04195 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY07_RS04200 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GPY07_RS04205 ENOG4107SC1 transglycosylase GPY07_RS04210 ENOG4105C5H ABC transporter GPY07_RS04225 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY07_RS04230 ENOG4108HRK Histidine kinase GPY07_RS04235 ENOG4108NEV two component transcriptional regulator, LytTR family GPY07_RS04240 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GPY07_RS04245 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GPY07_RS04250 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY07_RS04270 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GPY07_RS04275 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GPY07_RS04280 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GPY07_RS04285 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GPY07_RS04290 ENOG4105DTN riboflavin biosynthesis protein ribF GPY07_RS04295 ENOG4105CJR Integral membrane protein (MviN GPY07_RS04300 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GPY07_RS04305 ENOG41080HT Transcriptional regulator, arsr family GPY07_RS04310 ENOG41063Z6 transcriptional regulator, lysR family GPY07_RS04320 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GPY07_RS04325 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GPY07_RS04330 ENOG4105HF0 Membrane GPY07_RS04335 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GPY07_RS04340 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GPY07_RS04345 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GPY07_RS04350 ENOG4105CPC Aldo Keto reductase GPY07_RS04365 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS04370 ENOG4105CRK lysyL-tRNA synthetase GPY07_RS04380 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPY07_RS04385 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GPY07_RS04390 ENOG4105C1J atp-dependent rna helicase GPY07_RS04395 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GPY07_RS04455 ENOG4105BZU Histidine kinase GPY07_RS04460 ENOG4105BZU Histidine kinase GPY07_RS04480 ENOG4108YGG dna repair protein GPY07_RS04505 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GPY07_RS04520 ENOG4108UUM single-stranded DNA-binding protein GPY07_RS04535 ENOG4105RWS endonuclease I GPY07_RS04585 ENOG4105T95 Thiol disulfide interChange protein GPY07_RS04630 ENOG4105MRD Phage derived protein Gp49-like (DUF891) GPY07_RS04660 ENOG4105ESI atpase involved in dna repair GPY07_RS04725 ENOG4105KT5 UmuD protein GPY07_RS04755 ENOG4108R0M Aminoglycoside GPY07_RS04790 ENOG4105DHP deoxycytidine triphosphate deaminase GPY07_RS04860 ENOG4105BZU Histidine kinase GPY07_RS04875 ENOG4108YYD acetyltransferase GPY07_RS04880 ENOG4105XPQ lipid carrier protein GPY07_RS04885 ENOG4105BZU Histidine kinase GPY07_RS04890 ENOG4105CFP Peptidase U32 GPY07_RS04895 ENOG4106RZ4 Peptidase U32 GPY07_RS04910 ENOG4105RT1 May be involved in cell division (By similarity) GPY07_RS04915 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GPY07_RS04920 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GPY07_RS04925 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GPY07_RS04930 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GPY07_RS04935 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GPY07_RS04940 ENOG4105CHV Transcription elongation factor NusA GPY07_RS04945 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GPY07_RS04965 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GPY07_RS04970 ENOG4105EEI dihydropteroate synthase GPY07_RS04975 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GPY07_RS04980 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GPY07_RS04985 ENOG4105HBR Rna-binding protein GPY07_RS04990 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPY07_RS04995 ENOG4105FCK Membrane GPY07_RS05000 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GPY07_RS05005 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY07_RS05010 ENOG4105DR5 peptidase GPY07_RS05025 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GPY07_RS05030 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GPY07_RS05040 ENOG4105IPI Membrane GPY07_RS05045 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY07_RS05050 ENOG4105BZU Histidine kinase GPY07_RS05055 ENOG4107QRA Extracellular solute-binding protein, family 5 GPY07_RS05065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY07_RS05070 ENOG4105C3U ABC transporter GPY07_RS05075 ENOG4108JQ7 (ABC) transporter GPY07_RS05085 ENOG4105RD7 BadF BadG BcrA BcrD GPY07_RS05090 ENOG4105E2D ec 3.2.1.52 GPY07_RS05095 ENOG4105E2V Glycosyltransferase 36 GPY07_RS05105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS05125 ENOG4108YZA Nitrogen regulatory protein pii GPY07_RS05130 ENOG4105XTV UPF0231 protein GPY07_RS05135 ENOG4107QIJ Aconitate hydratase 2 GPY07_RS05140 ENOG4105D78 K07001 NTE family protein GPY07_RS05145 ENOG4105BZ4 penicillin-binding protein GPY07_RS05150 ENOG4105CQ7 ATP-dependent helicase GPY07_RS05160 ENOG4105PW4 Sugar fermentation stimulation protein homolog GPY07_RS05165 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GPY07_RS05170 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GPY07_RS05175 ENOG4105DJ0 Poly(A) Polymerase GPY07_RS05180 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY07_RS05185 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GPY07_RS05190 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GPY07_RS05195 ENOG4105E3A (ABC) transporter GPY07_RS05200 ENOG4105DA5 (ABC) transporter GPY07_RS05205 ENOG4105CHH sulfate transporter GPY07_RS05210 ENOG41077A9 carbonic anhydrase GPY07_RS05215 ENOG4108UGV hypoxanthine phosphoribosyltransferase GPY07_RS05220 ENOG410630P Transcriptional regulator GPY07_RS05225 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GPY07_RS05230 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) GPY07_RS05235 ENOG41082RQ UPF0102 protein GPY07_RS05240 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY07_RS05245 ENOG4105W4M Transport-associated protein GPY07_RS05250 ENOG4105KB2 stringent starvation protein b GPY07_RS05255 ENOG4107MKT Stringent starvation protein a GPY07_RS05260 ENOG4105EIX cytochrome c1 GPY07_RS05265 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY07_RS05270 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY07_RS05275 ENOG4108UJD 30S ribosomal protein S9 GPY07_RS05280 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GPY07_RS05285 ENOG4105D6Z AFG1 family ATPase GPY07_RS05295 ENOG4105C0H protease GPY07_RS05300 ENOG4105C0H protease GPY07_RS05305 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GPY07_RS05310 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GPY07_RS05315 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GPY07_RS05320 ENOG4105K5M 30s ribosomal protein S16 GPY07_RS05325 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GPY07_RS05330 ENOG4106KVJ cytochrome C assembly protein GPY07_RS05335 ENOG4108JU6 CBS domain protein GPY07_RS05340 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GPY07_RS05345 ENOG4105D9M gamma-glutamylcysteine synthetase GPY07_RS05355 ENOG4105W39 Membrane GPY07_RS05365 ENOG4105D9Q decarboxylase (Beta subunit) GPY07_RS05370 ENOG4107QSA Oxaloacetate decarboxylase GPY07_RS05420 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GPY07_RS05425 ENOG4105CFH Aspartokinase GPY07_RS05430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GPY07_RS05435 ENOG4105Y3E Modulates RecA activity (By similarity) GPY07_RS05440 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GPY07_RS05450 ENOG4108IJ6 ABC transporter GPY07_RS05455 ENOG4105ECW sulfate abc transporter GPY07_RS05460 ENOG4108I5D sulfate abc transporter GPY07_RS05465 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GPY07_RS05470 ENOG4105C6T cysteine synthase GPY07_RS05475 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GPY07_RS05480 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY07_RS05485 ENOG4108K5P (LipO)protein GPY07_RS05490 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GPY07_RS05495 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GPY07_RS05500 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GPY07_RS05505 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GPY07_RS05510 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GPY07_RS05520 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GPY07_RS05525 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY07_RS05530 ENOG4107ZVW dihydroneopterin aldolase GPY07_RS05535 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GPY07_RS05545 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY07_RS05550 ENOG4105VCC 30S ribosomal protein S21 GPY07_RS05555 ENOG4105KTH gatB Yqey GPY07_RS05560 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GPY07_RS05565 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY07_RS05575 ENOG4105DFP Integrase GPY07_RS05580 ENOG4105D58 Diguanylate phosphodiesterase GPY07_RS05585 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS05595 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GPY07_RS05605 ENOG4108YGG dna repair protein GPY07_RS05640 ENOG4105DR5 peptidase GPY07_RS05665 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY07_RS05715 ENOG4105CH5 extracellular solute-binding protein, family 7 GPY07_RS05720 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GPY07_RS05725 ENOG410804X Transcriptional regulator GPY07_RS05730 ENOG4105CA9 Pyruvate kinase GPY07_RS05735 ENOG4105MPN Membrane GPY07_RS05740 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GPY07_RS05745 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GPY07_RS05750 ENOG4105D64 Mechanosensitive ion channel GPY07_RS05760 ENOG4105D2N Aldolase GPY07_RS05765 ENOG4105BZA Phosphoglycerate kinase GPY07_RS05770 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY07_RS05775 ENOG4105D05 Receptor GPY07_RS05780 ENOG4108R4R Iron-regulated virulence regulatory protein GPY07_RS05785 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY07_RS05790 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GPY07_RS05795 ENOG4105GPY SprT protein GPY07_RS05800 ENOG4105RWS endonuclease I GPY07_RS05805 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GPY07_RS05810 ENOG4105D7Z glutathione synthase GPY07_RS05815 ENOG4108UJU UPF0301 protein GPY07_RS05820 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GPY07_RS05825 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY07_RS05835 ENOG4105CZX twitching motility protein GPY07_RS05840 ENOG4105CZX twitching motility protein GPY07_RS05845 ENOG4105DFA alanine racemase domain protein GPY07_RS05850 ENOG4105II7 pyrroline-5-carboxylate reductase GPY07_RS05855 ENOG4108VIA integral membrane protein GPY07_RS05860 ENOG4105VZ9 UPF0235 protein GPY07_RS05870 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY07_RS05875 ENOG4105CSA Coproporphyrinogen iii oxidase GPY07_RS05880 ENOG4105CSV Glutaminase GPY07_RS05885 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GPY07_RS05890 ENOG4105CEN a g-specific adenine glycosylase GPY07_RS05895 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GPY07_RS05900 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GPY07_RS05955 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GPY07_RS05960 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GPY07_RS05965 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GPY07_RS05970 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GPY07_RS05975 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GPY07_RS05980 ENOG4105NWN ApaG protein GPY07_RS05985 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GPY07_RS05995 ENOG4107XM3 UPF0442 protein GPY07_RS06000 ENOG4105DWK Membrane GPY07_RS06005 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GPY07_RS06010 ENOG4105K46 50S ribosomal protein l27 GPY07_RS06015 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GPY07_RS06020 ENOG4105EAH synthase GPY07_RS06030 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GPY07_RS06035 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GPY07_RS06050 ENOG41081QV Universal stress protein GPY07_RS06070 ENOG4105CEU Arginine dihydrolase GPY07_RS06075 ENOG4105D1U peptidase U62 modulator of DNA gyrase GPY07_RS06085 ENOG4105QD6 exported protein GPY07_RS06090 ENOG4105C03 ribonuclease GPY07_RS06095 ENOG4108Z03 MAF-like protein GPY07_RS06100 ENOG4105VQ7 Rod shape-determining protein MreD GPY07_RS06105 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GPY07_RS06110 ENOG4105DFF Rod shape-determining protein mreb GPY07_RS06145 ENOG4105X0D Fimbrial protein GPY07_RS06155 ENOG4105D7Q type ii secretion system GPY07_RS06160 ENOG4107QHF type ii secretion system protein e GPY07_RS06175 ENOG4105E4G Type IV pilus GPY07_RS06195 ENOG41062P1 Diguanylate cyclase phosphodiesterase GPY07_RS06200 ENOG4108UUM single-stranded DNA-binding protein GPY07_RS06205 ENOG41086KC Transcriptional regulator GPY07_RS06210 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPY07_RS06215 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GPY07_RS06225 ENOG4105C5R Aminotransferase GPY07_RS06230 ENOG4105CFH Aspartokinase GPY07_RS06235 ENOG4105C3R Methionine synthase GPY07_RS06240 ENOG4105EEQ Na H antiporter GPY07_RS06305 ENOG4108Z0R Transferase GPY07_RS06315 ENOG4105E2X shikimate dehydrogenase GPY07_RS06320 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GPY07_RS06325 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY07_RS06330 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GPY07_RS06335 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GPY07_RS06340 ENOG4108WI1 Dna topoisomerase GPY07_RS06345 ENOG4108RPN Protein smg homolog GPY07_RS06350 ENOG4105C79 DNA protecting protein DprA GPY07_RS06355 ENOG4108WZM domain protein GPY07_RS06360 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY07_RS06365 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GPY07_RS06370 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY07_RS06375 ENOG4105C1A potassium transporter peripheral membrane GPY07_RS06380 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY07_RS06390 ENOG4108UT2 hemolysin iii GPY07_RS06395 ENOG4108N23 SpoOM-related protein GPY07_RS06405 ENOG4105PC1 Conserved Protein GPY07_RS06415 ENOG4105E27 serine threonine protein kinase GPY07_RS06420 ENOG4108Z33 Thiol disulfide Interchange Protein GPY07_RS06425 ENOG4106HNH Acyl-transferase GPY07_RS06430 ENOG4105C0P Mg chelatase subunit ChlI GPY07_RS06445 ENOG4105CM2 brancheD-chain amino acid aminotransferase GPY07_RS06450 ENOG4105C01 Dihydroxy-acid dehydratase GPY07_RS06455 ENOG4105C7B Threonine dehydratase GPY07_RS06460 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GPY07_RS06470 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GPY07_RS06485 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit GPY07_RS06490 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GPY07_RS06495 ENOG4105JKW Valine--pyruvate aminotransferase GPY07_RS06500 ENOG4108ZNX Heat shock protein GPY07_RS06515 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY07_RS06520 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GPY07_RS06525 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GPY07_RS06530 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GPY07_RS06535 ENOG4105EAB amino acid AbC transporter GPY07_RS06540 ENOG4105E5Q amino acid AbC transporter GPY07_RS06555 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GPY07_RS06560 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GPY07_RS06565 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GPY07_RS06570 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GPY07_RS06575 ENOG4105QTB Flavodoxin GPY07_RS06585 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GPY07_RS06590 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GPY07_RS06595 ENOG4107QJE Chromosome Partitioning Protein GPY07_RS06600 ENOG4105FA0 parb-like partition protein GPY07_RS06605 ENOG410684E atp synthase GPY07_RS06610 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GPY07_RS06615 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY07_RS06620 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY07_RS06625 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY07_RS06630 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GPY07_RS06635 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GPY07_RS06640 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GPY07_RS06645 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GPY07_RS06650 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPY07_RS06655 ENOG4105CZQ inner membrane transport protein YdhC GPY07_RS06660 ENOG4105F52 Transcriptional regulator GPY07_RS06665 ENOG4105CHU acetyl-coa acetyltransferase GPY07_RS06670 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY07_RS06675 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GPY07_RS06680 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY07_RS06685 ENOG4108RR8 protoporphyrinogen oxidase GPY07_RS06730 ENOG4105EMY transcriptional regulator GPY07_RS06735 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GPY07_RS06740 ENOG4105W0Z cytoplasmic protein GPY07_RS06745 ENOG4105BZS acriflavin resistance protein GPY07_RS06750 ENOG410624X efflux transporter, rnd family, mfp subunit GPY07_RS06755 ENOG4105Y7M Transcriptional regulator, TetR family GPY07_RS06760 ENOG4105C4R Atp-dependent dna helicase GPY07_RS06765 ENOG4105MPD Cytochrome GPY07_RS06810 ENOG4105DEF Extracellular solute-binding protein, family 5 GPY07_RS06815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY07_RS06820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY07_RS06830 ENOG4108UK2 deaminase GPY07_RS06860 ENOG4108ZXE GPY07_RS06895 ENOG4105DC8 reductase GPY07_RS06900 ENOG4105D6S protein involved in catabolism of external DNA GPY07_RS06905 ENOG4105DGW oligopeptidase A GPY07_RS06910 ENOG4105C4R Atp-dependent dna helicase GPY07_RS06920 ENOG4108DMH HTH_ARAC GPY07_RS06935 ENOG4105C9U ATP-dependent DNA helicase RecQ GPY07_RS06950 ENOG4105BZ1 (ABC) transporter GPY07_RS06955 ENOG4105E0K tonB-dependent siderophore receptor GPY07_RS06960 ENOG4105E0A ABC, transporter GPY07_RS06965 ENOG4105J76 Periplasmic binding protein GPY07_RS06970 ENOG4105S6R Iron-hydroxamate transporter permease subunit GPY07_RS06975 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) GPY07_RS06985 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY07_RS06990 ENOG4105C5Y PTS System GPY07_RS07000 ENOG4105DSJ YicC domain protein GPY07_RS07005 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GPY07_RS07010 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GPY07_RS07015 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GPY07_RS07020 ENOG4105D1S lipid A biosynthesis GPY07_RS07025 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GPY07_RS07035 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GPY07_RS07040 ENOG4108NVR Methyl-accepting chemotaxis GPY07_RS07050 ENOG4105KDC 50s ribosomal protein l28 GPY07_RS07055 ENOG4105W0E 50S ribosomal protein L33 GPY07_RS07065 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GPY07_RS07070 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GPY07_RS07075 ENOG4105M5K heptosyltransferase GPY07_RS07080 ENOG4106WTF Glycosyl transferase, family 2 GPY07_RS07085 ENOG4105DKP glycosyl transferase, family 9 GPY07_RS07090 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) GPY07_RS07120 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GPY07_RS07125 ENOG4108ST3 glycosyltransferase GPY07_RS07135 ENOG4105XA0 heptosyltransferase ii GPY07_RS07150 ENOG4107T94 Endo-14-beta-xylanase GPY07_RS07155 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GPY07_RS07165 ENOG4105E3R (LipO)protein GPY07_RS07175 ENOG4108MDC (LipO)protein GPY07_RS07200 ENOG410600T transposase GPY07_RS07220 ENOG4105FGF GDP-mannose mannosyl hydrolase GPY07_RS07245 ENOG4105K64 Glycosyl transferase, family 2 GPY07_RS07250 ENOG4105K64 Glycosyl transferase, family 2 GPY07_RS07260 ENOG4105CAQ asparagine synthetase GPY07_RS07265 ENOG4105CGN Glycosyl transferase (Group 1 GPY07_RS07270 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GPY07_RS07275 ENOG4106ECQ phosphomannomutase GPY07_RS07285 ENOG4105D3Q Sugar transferase GPY07_RS07305 ENOG4105CY0 Metallo-Beta-Lactamase GPY07_RS07320 ENOG4105CUY Mechanosensitive ion channel GPY07_RS07325 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GPY07_RS07330 ENOG4105R2J Conserved Protein GPY07_RS07340 ENOG4105K70 DNA-binding protein GPY07_RS07350 ENOG4105C12 Phosphoribosylglycinamide synthetase GPY07_RS07355 ENOG4105DC1 bifunctional purine biosynthesis protein purh GPY07_RS07365 ENOG4105W1Y Transcriptional regulator GPY07_RS07370 ENOG4108M3R transcriptional activator CadC GPY07_RS07375 ENOG4105D5Q Arginine ornithine antiporter GPY07_RS07380 ENOG4105CXN decarboxylase GPY07_RS07385 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS07400 ENOG4108UHU Aldolase GPY07_RS07405 ENOG4105C6Z Gluconate GPY07_RS07410 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GPY07_RS07415 ENOG4105C01 Dihydroxy-acid dehydratase GPY07_RS07420 ENOG4105DIQ Transcriptional regulator GPY07_RS07425 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GPY07_RS07430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY07_RS07435 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GPY07_RS07440 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GPY07_RS07445 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GPY07_RS07450 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GPY07_RS07455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY07_RS07475 ENOG4105D8G Major Facilitator superfamily GPY07_RS07480 ENOG4105BZU Histidine kinase GPY07_RS07485 ENOG4105C9X ppx gppa phosphatase GPY07_RS07490 ENOG4105C1J atp-dependent rna helicase GPY07_RS07495 ENOG4105K63 Thioredoxin GPY07_RS07500 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GPY07_RS07510 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GPY07_RS07520 ENOG4107QK7 reductase GPY07_RS07555 ENOG4105JIM Phosphatidylserine synthase GPY07_RS07565 ENOG4105D4A Cell wall formation (By similarity) GPY07_RS07570 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GPY07_RS07575 ENOG4105CS9 pantothenic acid kinase GPY07_RS07600 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY07_RS07605 ENOG4105PM1 preprotein translocase subunit SecE GPY07_RS07610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GPY07_RS07615 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GPY07_RS07620 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GPY07_RS07625 ENOG4108VZM 50s ribosomal protein L10 GPY07_RS07630 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GPY07_RS07635 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY07_RS07640 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY07_RS07645 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor GPY07_RS07650 ENOG4105E09 nadh pyrophosphatase GPY07_RS07655 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GPY07_RS07660 ENOG41062JF Transcriptional regulator GPY07_RS07670 ENOG41063SB peptidase GPY07_RS07675 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GPY07_RS07685 ENOG4107QWE )-transporter GPY07_RS07690 ENOG4105DJ4 phosphatidylserine decarboxylase GPY07_RS07695 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GPY07_RS07700 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GPY07_RS07745 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GPY07_RS07750 ENOG4105K8N protein family UPF0079, ATPase GPY07_RS07755 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GPY07_RS07760 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GPY07_RS07765 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GPY07_RS07770 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GPY07_RS07775 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GPY07_RS07780 ENOG4107QJR hflk protein GPY07_RS07785 ENOG4105EPW hflc protein GPY07_RS07795 ENOG41069P5 Protein slyX homolog GPY07_RS07805 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY07_RS07810 ENOG4105WWK YheO domain protein GPY07_RS07815 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GPY07_RS07820 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPY07_RS07830 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GPY07_RS07835 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GPY07_RS07840 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY07_RS07845 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY07_RS07850 ENOG4105W53 bacterioferritin-associated ferredoxin GPY07_RS07855 ENOG4108UQY Iron-storage protein GPY07_RS07860 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GPY07_RS07865 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GPY07_RS07870 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GPY07_RS07875 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GPY07_RS07885 ENOG4105CDU Replicative dna helicase GPY07_RS07890 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY07_RS07895 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GPY07_RS07900 ENOG4107QP8 phosphohexose isomerase GPY07_RS07915 ENOG4105MYN Zinc uptake regulation protein GPY07_RS07920 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY07_RS07925 ENOG4105P4Z Phage shock protein G GPY07_RS07945 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GPY07_RS07950 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GPY07_RS07955 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GPY07_RS07995 ENOG4105WMR Protein CrcB homolog GPY07_RS08000 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GPY07_RS08010 ENOG4105D06 uba thif-type nad fad binding protein GPY07_RS08015 ENOG4105WHD thiamine biosynthesis protein ThiS GPY07_RS08020 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GPY07_RS08025 ENOG4105D41 biosynthesis protein thiH GPY07_RS08030 ENOG4105DC7 peptidase M24 GPY07_RS08030 ENOG4105DC7 peptidase M24 GPY07_RS08040 ENOG4105CNH Multidrug resistance protein MdtL GPY07_RS08050 ENOG4108VVK transcriptional Regulator, AsnC GPY07_RS08055 ENOG4105BZU Histidine kinase GPY07_RS08060 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GPY07_RS08070 ENOG4105EMK carboxylate amino acid amine transporter GPY07_RS08075 ENOG4108M6U Universal stress protein A GPY07_RS08085 ENOG41090A1 ferritin GPY07_RS08090 ENOG4108V6B universal stress protein B GPY07_RS08095 ENOG4105CBX hi0933 family GPY07_RS08105 ENOG4105CGY Dna recombination protein GPY07_RS08110 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GPY07_RS08115 ENOG4105JC1 sterol-binding domain protein GPY07_RS08120 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GPY07_RS08125 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GPY07_RS08130 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GPY07_RS08135 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GPY07_RS08140 ENOG4105CA0 peroxidase GPY07_RS08145 ENOG4107R73 Mate efflux family protein GPY07_RS08155 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GPY07_RS08160 ENOG4105E55 glycerol-3-phosphate acyltransferase GPY07_RS08165 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GPY07_RS08170 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GPY07_RS08180 ENOG4105X6C Flagellar basal body-associated protein FliL GPY07_RS08185 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS08195 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPY07_RS08200 ENOG4105F8V Hydrolase, tatD family GPY07_RS08205 ENOG4105D52 delta-aminolevulinic acid dehydratase GPY07_RS08215 ENOG4105C2M dna polymerase I GPY07_RS08220 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GPY07_RS08225 ENOG4106RE7 Cytochrome GPY07_RS08235 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GPY07_RS08240 ENOG4105XCT Protein of unknown function (DUF2489) GPY07_RS08245 ENOG4105D4P Coproporphyrinogen iii oxidase GPY07_RS08250 ENOG410601J HemY protein GPY07_RS08255 ENOG4105ECF c-methyltransferase GPY07_RS08260 ENOG41076E6 Uroporphyrinogen-III Synthase GPY07_RS08265 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GPY07_RS08275 ENOG4107T0K Adenylate cyclase GPY07_RS08280 ENOG4105XQ6 frataxin-like protein GPY07_RS08290 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GPY07_RS08295 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GPY07_RS08300 ENOG4105CT0 Protein of unknown function, DUF484 GPY07_RS08305 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY07_RS08310 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GPY07_RS08315 ENOG4105BZU Histidine kinase GPY07_RS08330 ENOG4105DQF Hydrolase GPY07_RS08335 ENOG4108EUD Lysophospholipase GPY07_RS08340 ENOG410829K Lysine exporter protein (Lyse ygga) GPY07_RS08345 ENOG4105D58 Diguanylate phosphodiesterase GPY07_RS08350 ENOG4108RMU ferritin dps family protein GPY07_RS08380 ENOG4106H78 methyltransferase GPY07_RS08385 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GPY07_RS08390 ENOG4105CAK Cell division ATP-binding protein ftsE GPY07_RS08395 ENOG4105CRP Part of the ABC transporter FtsEX involved in GPY07_RS08400 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY07_RS08405 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GPY07_RS08420 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) GPY07_RS08425 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GPY07_RS08430 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY07_RS08435 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GPY07_RS08505 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GPY07_RS08510 ENOG4105BZU Histidine kinase GPY07_RS08515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS08520 ENOG4105CUX Signal transduction histidine kinase GPY07_RS08530 ENOG4105C5F glutamine synthetase GPY07_RS08545 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GPY07_RS08555 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GPY07_RS08560 ENOG4105SUU thioesterase domain GPY07_RS08570 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GPY07_RS08575 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GPY07_RS08580 ENOG4105VEJ Heat shock protein GPY07_RS08585 ENOG4108XKW General secretion pathway protein C GPY07_RS08595 ENOG4107QHF type ii secretion system protein e GPY07_RS08600 ENOG4105D7Q type ii secretion system GPY07_RS08605 ENOG4108VAU general secretion pathway protein G GPY07_RS08610 ENOG4105VWV general secretion pathway protein h GPY07_RS08615 ENOG4105X5Z General secretion pathway protein I GPY07_RS08620 ENOG4108WWZ General secretion pathway protein J GPY07_RS08625 ENOG4108RTD type II secretion system protein K GPY07_RS08630 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) GPY07_RS08635 ENOG4105U1E general secretion pathway protein M GPY07_RS08640 ENOG4105PIC general secretion pathway protein N GPY07_RS08645 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GPY07_RS08650 ENOG4107RK2 ADP-ribose diphosphatase NudE GPY07_RS08655 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) GPY07_RS08660 ENOG4105MJ2 Competence protein GPY07_RS08665 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY07_RS08675 ENOG4105BZM domain protein GPY07_RS08680 ENOG4108RRZ Transcription elongation factor GreB GPY07_RS08685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY07_RS08690 ENOG4105E0F Histidine kinase GPY07_RS08695 ENOG4105C2W permease GPY07_RS08705 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY07_RS08710 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GPY07_RS08715 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GPY07_RS08720 ENOG4105EX9 Membrane GPY07_RS08725 ENOG4107QN1 sodium solute GPY07_RS08735 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GPY07_RS08745 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GPY07_RS08755 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY07_RS08760 ENOG4108IJ0 Aspartate ammonia-lyase GPY07_RS08765 ENOG4105BZU Histidine kinase GPY07_RS08770 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GPY07_RS08775 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GPY07_RS08785 ENOG4105E0F Histidine kinase GPY07_RS08790 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY07_RS08800 ENOG41076HS cation diffusion facilitator family transporter GPY07_RS08805 ENOG4105CTQ phosphohexokinase GPY07_RS08810 ENOG4105CBT Fructose-1,6-bisphosphatase GPY07_RS08815 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GPY07_RS08820 ENOG4105SYT Methylenetetrahydrofolate reductase GPY07_RS08825 ENOG4105CFH Aspartokinase GPY07_RS08830 ENOG4105C28 cystathionine GPY07_RS08835 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GPY07_RS08840 ENOG4105C6K Malic enzyme GPY07_RS08845 ENOG4105VFB Binds the 23S rRNA (By similarity) GPY07_RS08850 ENOG4105C25 Primosomal protein n' GPY07_RS08855 ENOG4105ETE Transcriptional regulator (LacI family GPY07_RS08860 ENOG41063M6 Cell Division Protein GPY07_RS08865 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GPY07_RS08870 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GPY07_RS08875 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GPY07_RS08880 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY07_RS08890 ENOG4105CP7 Triose-phosphate isomerase GPY07_RS08915 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY07_RS08920 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY07_RS08930 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GPY07_RS08935 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY07_RS08940 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY07_RS08945 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY07_RS08950 ENOG4105E33 succinate dehydrogenase GPY07_RS08960 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GPY07_RS08965 ENOG4107YZP Rhodanese domain protein GPY07_RS08970 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GPY07_RS08975 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GPY07_RS08980 ENOG4105D7W serine acetyltransferase GPY07_RS08990 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GPY07_RS08995 ENOG4105CWC Acetylornithine deacetylase GPY07_RS09000 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GPY07_RS09005 ENOG4105CAS nag kinase GPY07_RS09010 ENOG4105CDH Citrulline--aspartate ligase GPY07_RS09015 ENOG4105CH7 arginosuccinase GPY07_RS09025 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY07_RS09030 ENOG4105EHV domain protein GPY07_RS09040 ENOG4108JQC penicillin-binding protein 1A GPY07_RS09065 ENOG4105E4G Type IV pilus GPY07_RS09070 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GPY07_RS09075 ENOG4105D49 3-dehydroquinate synthase GPY07_RS09085 ENOG4105DFE Dna adenine methylase GPY07_RS09090 ENOG4105DJV ribulose-phosphate 3-epimerase GPY07_RS09095 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY07_RS09100 ENOG4105C31 Tryptophanyl-tRNA synthetase GPY07_RS09115 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GPY07_RS09120 ENOG4105DDQ anthranilate synthase GPY07_RS09125 ENOG4105C8Y Acetylornithine aminotransferase GPY07_RS09135 ENOG4105C26 Dehydrogenase GPY07_RS09145 ENOG4107RYR Transcriptional regulator, Crp Fnr family GPY07_RS09150 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GPY07_RS09160 ENOG4105DNZ Alpha Beta Hydrolase GPY07_RS09170 ENOG4105C5H ABC transporter GPY07_RS09175 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPY07_RS09190 ENOG4108YZY peptidylprolyl cis-trans isomerase GPY07_RS09195 ENOG4105D44 asparaginase GPY07_RS09200 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPY07_RS09205 ENOG4108UV7 flagellar protein motX GPY07_RS09210 ENOG4105E68 Sulfatase GPY07_RS09220 ENOG4105C2N RNA methyltransferase TrmH family group 3 GPY07_RS09225 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GPY07_RS09230 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GPY07_RS09235 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GPY07_RS09240 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GPY07_RS09245 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GPY07_RS09250 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GPY07_RS09255 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GPY07_RS09260 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GPY07_RS09265 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GPY07_RS09270 ENOG41083MP 50s ribosomal protein l29 GPY07_RS09275 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GPY07_RS09280 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GPY07_RS09285 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GPY07_RS09290 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GPY07_RS09295 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GPY07_RS09300 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GPY07_RS09305 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GPY07_RS09310 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GPY07_RS09315 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GPY07_RS09320 ENOG4105VPB 50S ribosomal protein L30 GPY07_RS09325 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GPY07_RS09330 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GPY07_RS09340 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GPY07_RS09345 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GPY07_RS09350 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GPY07_RS09355 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY07_RS09360 ENOG4108ZT0 50S ribosomal protein l17 GPY07_RS09370 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY07_RS09375 ENOG4108UBT opacity-associated protein GPY07_RS09380 ENOG4108SXK Transporter Drug Metabolite Exporter family GPY07_RS09385 ENOG4107YB6 acetyltransferase, (GNAT) family GPY07_RS09390 ENOG4105C1J atp-dependent rna helicase GPY07_RS09400 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GPY07_RS09405 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY07_RS09410 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GPY07_RS09415 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) GPY07_RS09420 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) GPY07_RS09440 ENOG4105C19 ABC transporter GPY07_RS09455 ENOG4108UUE Transcriptional regulator GPY07_RS09460 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GPY07_RS09465 ENOG4105CFU surface antigen GPY07_RS09475 ENOG41066HZ AIG2-like family GPY07_RS09480 ENOG4105F0N pyrophosphate phospho-hydrolase GPY07_RS09485 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GPY07_RS09490 ENOG4105DFU Cell wall formation (By similarity) GPY07_RS09495 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GPY07_RS09500 ENOG4105DP9 ABC transporter GPY07_RS09505 ENOG4106SMU thiamine transporter membrane protein GPY07_RS09510 ENOG4107T0D ABC, transporter GPY07_RS09515 ENOG4105N42 UPF0307 protein GPY07_RS09520 ENOG4105CMS peptidase U62, modulator of DNA gyrase GPY07_RS09525 ENOG4105CJW magnesium transporter GPY07_RS09530 ENOG41080Z8 PHOSPHOCARRIER protein GPY07_RS09535 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GPY07_RS09540 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GPY07_RS09545 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GPY07_RS09550 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY07_RS09555 ENOG4108IUZ ABC transporter GPY07_RS09560 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GPY07_RS09570 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GPY07_RS09575 ENOG4105C2X Arabinose 5-phosphate isomerase GPY07_RS09585 ENOG4105DHJ ABC, transporter GPY07_RS09590 ENOG4105CY3 ABC transporter, permease GPY07_RS09595 ENOG4107PE3 Mammalian cell entry related domain protein GPY07_RS09600 ENOG4105E3I toluene tolerance GPY07_RS09610 ENOG4105VFK BolA family GPY07_RS09615 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GPY07_RS09620 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GPY07_RS09625 ENOG4105KME endoribonuclease L-psp GPY07_RS09630 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GPY07_RS09635 ENOG4105CXT aspartate transcarbamylase GPY07_RS09640 ENOG4105DBV ornithine carbamoyltransferase GPY07_RS09645 ENOG4108IAB Phoh family GPY07_RS09650 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GPY07_RS09655 ENOG4105D3G Pseudouridine synthase GPY07_RS09660 ENOG4105C5I Dehydrogenase GPY07_RS09665 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GPY07_RS09670 ENOG4105MYG DNA polymerase iii, chi subunit GPY07_RS09675 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY07_RS09680 ENOG4108M8S permease YjgP YjgQ family protein GPY07_RS09685 ENOG4108K5H permease YjgP YjgQ family protein GPY07_RS09700 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY07_RS09745 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY07_RS09750 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY07_RS09755 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GPY07_RS09760 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GPY07_RS09780 ENOG41064T2 transcriptional regulator, lysR family GPY07_RS09785 ENOG4108IQE Amp-dependent synthetase and ligase GPY07_RS09790 ENOG4105C7K acetolactate synthase GPY07_RS09795 ENOG4108ZP8 Acetolactate synthase small subunit GPY07_RS09800 ENOG4108JQ1 Dehydrogenase GPY07_RS09805 ENOG4105E66 phosphoriboisomerase A GPY07_RS09810 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GPY07_RS09820 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GPY07_RS09830 ENOG4105D0A hydroxylase GPY07_RS09835 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY07_RS09845 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GPY07_RS09850 ENOG4105Y75 tpr repeat protein GPY07_RS09860 ENOG4108IYU L-aspartate oxidase GPY07_RS09865 ENOG4105EMN RNA polymerase sigma factor GPY07_RS09875 ENOG4105VQK sigma E regulatory protein, MucB RseB GPY07_RS09880 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GPY07_RS09885 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GPY07_RS09890 ENOG4105C3F Signal peptidase i GPY07_RS09895 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GPY07_RS09900 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GPY07_RS09905 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GPY07_RS09910 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GPY07_RS09915 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GPY07_RS09930 ENOG4108K0B C-di-gmp phosphodiesterase GPY07_RS09935 ENOG4105BZU Histidine kinase GPY07_RS09940 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GPY07_RS09945 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY07_RS09950 ENOG4105DXN mazG family GPY07_RS09955 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GPY07_RS09960 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GPY07_RS09965 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GPY07_RS09980 ENOG4106MWK domain protein GPY07_RS09985 ENOG4105CJ3 phosphate transporter GPY07_RS09990 ENOG4107IX6 phosphate transport regulator GPY07_RS09995 ENOG4105I7R Adenylate cyclase GPY07_RS10000 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS10005 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GPY07_RS10015 ENOG4105DFG type I secretion outer membrane protein GPY07_RS10020 ENOG41087AY ADP-Ribose pyrophosphatase GPY07_RS10025 ENOG4108SX3 cytoplasmic protein GPY07_RS10030 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GPY07_RS10035 ENOG4105IPS esterase GPY07_RS10040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY07_RS10045 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY07_RS10050 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GPY07_RS10055 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GPY07_RS10060 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GPY07_RS10065 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GPY07_RS10070 ENOG4105D7Q type ii secretion system GPY07_RS10075 ENOG4107QHF type ii secretion system protein e GPY07_RS10085 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GPY07_RS10095 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GPY07_RS10100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY07_RS10105 ENOG4105T95 Thiol disulfide interChange protein GPY07_RS10110 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GPY07_RS10115 ENOG4105CGH 5'-nucleotidase GPY07_RS10120 ENOG41073TP transcriptional regulator GPY07_RS10125 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GPY07_RS10130 ENOG4107QSN dihydrolipoamide acetyltransferase GPY07_RS10135 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY07_RS10145 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GPY07_RS10150 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPY07_RS10155 ENOG4105CJN penicillin-binding protein GPY07_RS10160 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GPY07_RS10165 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GPY07_RS10170 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GPY07_RS10175 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GPY07_RS10185 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GPY07_RS10190 ENOG4105DFU Cell wall formation (By similarity) GPY07_RS10195 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GPY07_RS10200 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GPY07_RS10205 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GPY07_RS10210 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY07_RS10220 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GPY07_RS10225 ENOG4105M6F mutator MutT protein GPY07_RS10230 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GPY07_RS10240 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GPY07_RS10245 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GPY07_RS10265 ENOG4107RRE RNA-directed DNA polymerase GPY07_RS10270 ENOG4105EJ9 Membrane GPY07_RS10275 ENOG4105VP0 transcriptional regulator, lysR family GPY07_RS10280 ENOG4105EN6 Membrane GPY07_RS10285 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GPY07_RS10295 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GPY07_RS10305 ENOG4105BZ8 glutamate synthase GPY07_RS10310 ENOG4105CBC glutamate synthase GPY07_RS10325 ENOG4105N5T Radical SAM Protein GPY07_RS10335 ENOG4105BZU Histidine kinase GPY07_RS10340 ENOG41065U4 response regulator GPY07_RS10350 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY07_RS10370 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GPY07_RS10375 ENOG4105D98 threonine synthase GPY07_RS10380 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GPY07_RS10385 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GPY07_RS10390 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GPY07_RS10405 ENOG4105BZG amino acid carrier protein GPY07_RS10420 ENOG4105EYA deoxyribonuclease GPY07_RS10425 ENOG4105D9N nucleoside GPY07_RS10435 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GPY07_RS10440 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GPY07_RS10445 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GPY07_RS10450 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY07_RS10460 ENOG4105EAC phosphoserine phosphatase GPY07_RS10470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GPY07_RS10475 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY07_RS10480 ENOG4108IQE Amp-dependent synthetase and ligase GPY07_RS10485 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY07_RS10495 ENOG4105CNT hydrolase family 2 GPY07_RS10500 ENOG41060NJ transcriptional regulator GPY07_RS10505 ENOG4108Y51 tRNA-binding protein GPY07_RS10520 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY07_RS10525 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GPY07_RS10535 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GPY07_RS10540 ENOG4105X2V dna damage-inducible protein GPY07_RS10555 ENOG4105DSY exodeoxyribonuclease V, gamma GPY07_RS10560 ENOG4107QKA exodeoxyribonuclease V beta GPY07_RS10565 ENOG4107QYX exodeoxyribonuclease v alpha GPY07_RS10575 ENOG4107QZM n-acetylglutamate synthase GPY07_RS10585 ENOG4105CA3 membrane-bound lytic murein transglycosylase GPY07_RS10590 ENOG4105CUZ uba thif-type nad fad binding protein GPY07_RS10595 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GPY07_RS10600 ENOG4105C9B Cysteine desulfurase GPY07_RS10605 ENOG4107S0N DJ-1 family GPY07_RS10610 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GPY07_RS10615 ENOG4105DRB nucleoside-specific channel-forming protein GPY07_RS10625 ENOG4105K6V RNA polymerase GPY07_RS10635 ENOG4105EYM Major Facilitator superfamily GPY07_RS10645 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY07_RS10655 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY07_RS10660 ENOG4105M85 Bola protein GPY07_RS10665 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY07_RS10670 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY07_RS10675 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY07_RS10680 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY07_RS10685 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY07_RS10690 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GPY07_RS10695 ENOG4105CJ2 (LipO)protein GPY07_RS10705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPY07_RS10720 ENOG4105C8J )-transporter GPY07_RS10730 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY07_RS10735 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY07_RS10745 ENOG4105C7N Xanthine uracil vitamin C permease GPY07_RS10750 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GPY07_RS10760 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GPY07_RS10765 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GPY07_RS10770 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GPY07_RS10775 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GPY07_RS10780 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPY07_RS10795 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GPY07_RS10800 ENOG4107YIM Involved in the transcription termination process (By similarity) GPY07_RS10805 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GPY07_RS10810 ENOG4108ZAI phosphatidylglycerophosphatase a GPY07_RS10815 ENOG4108T8E UPF0325 protein GPY07_RS10820 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GPY07_RS10825 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GPY07_RS10830 ENOG4105CE9 30S ribosomal protein S2 GPY07_RS10835 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GPY07_RS10840 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GPY07_RS10845 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GPY07_RS10850 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GPY07_RS10855 ENOG4105KNE Phosphatidate cytidylyltransferase GPY07_RS10860 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GPY07_RS10865 ENOG4105DZP Membrane-associated zinc metalloprotease GPY07_RS10875 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GPY07_RS10880 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY07_RS10885 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY07_RS10890 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY07_RS10895 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY07_RS10900 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY07_RS10905 ENOG4105C0B DNA polymerase III (alpha subunit) GPY07_RS10910 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GPY07_RS10915 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GPY07_RS10920 ENOG4105N7H Cytochrome GPY07_RS10925 ENOG4105PY6 Phenolic acid decarboxylase GPY07_RS10930 ENOG4108YZA Nitrogen regulatory protein pii GPY07_RS10940 ENOG4105E9H Lytic Murein transglycosylase GPY07_RS10945 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GPY07_RS10950 ENOG4105D1A Methyltransferase GPY07_RS10955 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY07_RS10960 ENOG4108JDX DNA polymerase iii, epsilon subunit GPY07_RS10970 ENOG4107QPN acyl-Coa dehydrogenase GPY07_RS10975 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY07_RS10980 ENOG4105E7A Glutamine amidotransferase GPY07_RS10985 ENOG4108V3E phosphoribosylglycinamide formyltransferase GPY07_RS10990 ENOG4105CXB phosphoribosylaminoimidazole synthetase GPY07_RS10995 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GPY07_RS11000 ENOG4105BZU Histidine kinase GPY07_RS11005 ENOG4105FE9 pseudouridine synthase GPY07_RS11010 ENOG4108DG9 Smr protein MutS2 GPY07_RS11025 ENOG4105MBR gumn family GPY07_RS11030 ENOG4105E2D ec 3.2.1.52 GPY07_RS11040 ENOG4105C59 p-type ATPase GPY07_RS11045 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GPY07_RS11050 ENOG4105UYK outer membrane protein a GPY07_RS11060 ENOG4107RBR Receptor GPY07_RS11065 ENOG4105Q26 Siderophore-interacting protein GPY07_RS11105 ENOG4107R88 Chemotaxis protein (CheV) GPY07_RS11110 ENOG4105BZU Histidine kinase GPY07_RS11115 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPY07_RS11120 ENOG4108ZC9 flagellar basal-body rod protein flgc GPY07_RS11125 ENOG4105W00 Flagellar hook capping protein GPY07_RS11130 ENOG4105BZE flagellar hook protein, FlgE GPY07_RS11135 ENOG4108KPB Flagellar basal-body rod protein FlgF GPY07_RS11140 ENOG4105CGA flagellar basal-body rod protein FlgG GPY07_RS11145 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY07_RS11150 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY07_RS11155 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPY07_RS11175 ENOG4105I03 Flagellin GPY07_RS11180 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY07_RS11200 ENOG4105MEH GPY07_RS11275 ENOG4105ED4 portal protein GPY07_RS11395 ENOG4105I03 Flagellin GPY07_RS11480 ENOG4105C3G gtp-binding protein GPY07_RS11485 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GPY07_RS11490 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GPY07_RS11495 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GPY07_RS11500 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GPY07_RS11505 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GPY07_RS11510 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GPY07_RS11515 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GPY07_RS11520 ENOG4108YY7 Invasion gene expression up-regulator SirB GPY07_RS11525 ENOG41063JG Transcriptional regulator GPY07_RS11530 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GPY07_RS11535 ENOG4105CGH 5'-nucleotidase GPY07_RS11540 ENOG4108Z66 YbaK ebsC protein GPY07_RS11545 ENOG4105C2W permease GPY07_RS11560 ENOG4105CS1 NAD(P)H quinone oxidoreductase GPY07_RS11565 ENOG4105K89 arsenate reductase GPY07_RS11570 ENOG4105ERG peptidase m48, ste24p GPY07_RS11585 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS11590 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GPY07_RS11605 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY07_RS11620 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPY07_RS11625 ENOG4105KUZ arsenate reductase GPY07_RS11640 ENOG4105QZU Inner membrane protein YfeZ GPY07_RS11645 ENOG4105EZR dyp-type peroxidase family protein GPY07_RS11650 ENOG4105I03 Flagellin GPY07_RS11655 ENOG4105I03 Flagellin GPY07_RS11660 ENOG4105I03 Flagellin GPY07_RS11665 ENOG41063QE flagellar protein FlaG GPY07_RS11670 ENOG4107W9T flagellar hook-associated GPY07_RS11680 ENOG4105MQ3 flagellar protein FliS GPY07_RS11685 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS11690 ENOG4105BZU Histidine kinase GPY07_RS11695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS11700 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GPY07_RS11705 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GPY07_RS11710 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY07_RS11715 ENOG4105W2B Flagellar assembly protein GPY07_RS11720 ENOG4108JIR Flagellum-specific ATP synthase GPY07_RS11740 ENOG4105X6C Flagellar basal body-associated protein FliL GPY07_RS11745 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY07_RS11750 ENOG4105DD5 Flagellar motor switch protein GPY07_RS11755 ENOG4105VTB flagellar biosynthesis protein fliO GPY07_RS11760 ENOG4105CN7 Flagellar biosynthetic protein FliP GPY07_RS11765 ENOG4105VS8 Flagellar biosynthetic protein fliq GPY07_RS11770 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPY07_RS11775 ENOG4105D00 flagellar biosynthetic protein flhB GPY07_RS11785 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GPY07_RS11790 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GPY07_RS11795 ENOG4105EN6 Membrane GPY07_RS11800 ENOG4108BPE -transporting atpase GPY07_RS11805 ENOG4105MH2 YfcL protein GPY07_RS11810 ENOG4105Q8W reductase GPY07_RS11815 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GPY07_RS11820 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY07_RS11825 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) GPY07_RS11830 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY07_RS11835 ENOG41090R7 Ferric uptake GPY07_RS11845 ENOG4105CMU LysR family (Transcriptional regulator GPY07_RS11850 ENOG4105VAW lrga family GPY07_RS11855 ENOG41067MG lrgb family GPY07_RS11860 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GPY07_RS11870 ENOG4105EV9 Alpha Beta Hydrolase GPY07_RS11875 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GPY07_RS11880 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GPY07_RS11890 ENOG4107QNR UPF0135 protein GPY07_RS11895 ENOG4105BZN citrate synthase GPY07_RS11900 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GPY07_RS11905 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GPY07_RS11910 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GPY07_RS11915 ENOG4105E33 succinate dehydrogenase GPY07_RS11920 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GPY07_RS11925 ENOG4105C7S Dehydrogenase GPY07_RS11930 ENOG4105CMV Succinyl-CoA synthetase subunit beta GPY07_RS11935 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GPY07_RS11940 ENOG4105FAV ABC, transporter GPY07_RS11945 ENOG4105FDK ABC transporter GPY07_RS11950 ENOG4105NXV High-affinity zinc uptake system protein GPY07_RS11955 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPY07_RS11960 ENOG4105XFK Ferrous iron transport protein A GPY07_RS11980 ENOG4105C75 arginyL-tRNA synthetase GPY07_RS11990 ENOG4108JQM Insulinase (Peptidase family M16) GPY07_RS11995 ENOG4108BY2 phosphohistidine phosphatase GPY07_RS12000 ENOG4105D7B Flagellar biosynthesis protein flha GPY07_RS12005 ENOG4105FZW flagellar biosynthesis regulator FlhF GPY07_RS12010 ENOG4107R21 site-determining protein GPY07_RS12015 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY07_RS12020 ENOG4108VYJ response regulator receiver protein GPY07_RS12025 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GPY07_RS12030 ENOG4105CBS Chea signal transduction histidine kinase GPY07_RS12035 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY07_RS12040 ENOG4107QJE Chromosome Partitioning Protein GPY07_RS12050 ENOG4108V3W Chemotaxis protein, CheW GPY07_RS12060 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GPY07_RS12065 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GPY07_RS12070 ENOG41060IM Heme exporter protein GPY07_RS12075 ENOG41067VX Heme exporter protein GPY07_RS12080 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GPY07_RS12085 ENOG4105DA4 cytochrome c-type biogenesis protein GPY07_RS12090 ENOG4107QX9 Thiol disulfide interChange protein GPY07_RS12095 ENOG4105KWW Biogenesis protein GPY07_RS12105 ENOG410903C (LipO)protein GPY07_RS12120 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPY07_RS12125 ENOG4105M2J Glutaredoxin GPY07_RS12130 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY07_RS12135 ENOG4105DGU Histone deacetylase GPY07_RS12150 ENOG4105E68 Sulfatase GPY07_RS12160 ENOG4106V8H Nucleoid-associated protein GPY07_RS12170 ENOG4105DFD Na H antiporter GPY07_RS12175 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY07_RS12180 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GPY07_RS12185 ENOG4108EKI Dehydrogenase GPY07_RS12195 ENOG4105CHH sulfate transporter GPY07_RS12200 ENOG4105C03 ribonuclease GPY07_RS12205 ENOG4105EI2 Pseudouridine synthase GPY07_RS12210 ENOG4108UHJ MAF-like protein GPY07_RS12215 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GPY07_RS12220 ENOG4105VGS 50s ribosomal protein l32 GPY07_RS12225 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GPY07_RS12230 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY07_RS12235 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GPY07_RS12240 ENOG4105CHR reductase GPY07_RS12245 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPY07_RS12250 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY07_RS12255 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GPY07_RS12260 ENOG4105HHA aminodeoxychorismate lyase GPY07_RS12265 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GPY07_RS12270 ENOG4107QRG dna polymerase iii GPY07_RS12275 ENOG4105F8V Hydrolase, tatD family GPY07_RS12280 ENOG4105CI1 PTS System GPY07_RS12290 ENOG4105C8J )-transporter GPY07_RS12305 ENOG4108NRW Phospholipase, patatin family GPY07_RS12310 ENOG4105CA9 Pyruvate kinase GPY07_RS12315 ENOG4105DAG ROK family GPY07_RS12320 ENOG4107R88 Chemotaxis protein (CheV) GPY07_RS12335 ENOG4105DHI Methyltransferase GPY07_RS12345 ENOG4105DSB aldose 1-epimerase GPY07_RS12350 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY07_RS12355 ENOG4105E0X reductase GPY07_RS12365 ENOG4105VUT cytoplasmic protein GPY07_RS12370 ENOG4105HDK L-asparaginase GPY07_RS12375 ENOG4105D07 Signal peptide peptidase, SppA GPY07_RS12380 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY07_RS12385 ENOG4105CIY formyltetrahydrofolate deformylase GPY07_RS12395 ENOG4105DVT helicase GPY07_RS12400 ENOG41072GX Peptidase M22 Glycoprotease GPY07_RS12415 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY07_RS12420 ENOG4105CEY Amp-dependent synthetase and ligase GPY07_RS12425 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GPY07_RS12445 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GPY07_RS12450 ENOG4105DK2 UPF0207 protein GPY07_RS12455 ENOG4105CHM Aminotransferase GPY07_RS12460 ENOG4105E4F Isochorismate synthase GPY07_RS12465 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GPY07_RS12470 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GPY07_RS12475 ENOG4108IPT Naphthoate synthase GPY07_RS12480 ENOG4105DNI Converts SHCHC to OSB (By similarity) GPY07_RS12485 ENOG4105CEY Amp-dependent synthetase and ligase GPY07_RS12490 ENOG4105DKK Benzoate GPY07_RS12495 ENOG4108JCI Transcriptional regulator GPY07_RS12500 ENOG4108N3W hemolysin secretion protein GPY07_RS12505 ENOG4107S74 Lysophospholipid transporter LplT GPY07_RS12530 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GPY07_RS12535 ENOG4107QMS site-determining protein GPY07_RS12540 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GPY07_RS12545 ENOG4105VNG YcgL domain-containing protein GPY07_RS12550 ENOG4105CVE Lytic murein transglycosylase GPY07_RS12555 ENOG4105JQN Transcriptional regulator GPY07_RS12560 ENOG4105D9N nucleoside GPY07_RS12565 ENOG410662T chitinase GPY07_RS12570 ENOG4105CUW cytochrome C-TYPE protein GPY07_RS12575 ENOG4107QY8 reductase GPY07_RS12590 ENOG4105JQN Transcriptional regulator GPY07_RS12605 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GPY07_RS12640 ENOG4108HPI phosphatidate Cytidylyltransferase GPY07_RS12650 ENOG4105BZU Histidine kinase GPY07_RS12665 ENOG4105CNG UPF0061 protein GPY07_RS12670 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GPY07_RS12675 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ GPY07_RS12680 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY07_RS12685 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS12700 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GPY07_RS12705 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GPY07_RS12710 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GPY07_RS12715 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GPY07_RS12720 ENOG4105K70 DNA-binding protein GPY07_RS12725 ENOG4105EIN peptidylprolyl cis-trans isomerase GPY07_RS12730 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GPY07_RS12735 ENOG4105CAT Cytidine monophosphate kinase GPY07_RS12740 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GPY07_RS12745 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY07_RS12750 ENOG4105Q4A inner membrane protein yciS GPY07_RS12755 ENOG4105CFV Tetratricopeptide repeat protein GPY07_RS12760 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GPY07_RS12765 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GPY07_RS12775 ENOG4107R11 Transcriptional regulator GPY07_RS12785 ENOG4105DCF alanine dehydrogenase GPY07_RS12790 ENOG4105EW9 transcriptional regulator AsnC family GPY07_RS12800 ENOG4105CNU cell division protein FtsK GPY07_RS12805 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GPY07_RS12810 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY07_RS12815 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GPY07_RS12825 ENOG4108NVR Methyl-accepting chemotaxis GPY07_RS12830 ENOG4105K59 histidine triad (HIT) protein GPY07_RS12860 ENOG4105CEP NADH dehydrogenase GPY07_RS12870 ENOG4106M3D hemolysin GPY07_RS12880 ENOG4108JA2 transcriptioN-repair coupling factor GPY07_RS12890 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY07_RS12895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY07_RS12900 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY07_RS12915 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GPY07_RS12920 ENOG4105BZ1 (ABC) transporter GPY07_RS12925 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GPY07_RS12935 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GPY07_RS12940 ENOG4105ED1 spovr family GPY07_RS12945 ENOG4106AKX UPF0229 protein GPY07_RS12950 ENOG4105CYN Serine protein kinase GPY07_RS12955 ENOG4105XWI UPF0304 protein GPY07_RS12965 ENOG4105F1A Pyruvate formate-lyase GPY07_RS12970 ENOG4108N3W hemolysin secretion protein GPY07_RS12980 ENOG4105C6N Formate acetyltransferase GPY07_RS12990 ENOG4108JEH abc transporter atp-binding protein GPY07_RS12995 ENOG4105E89 ABC transporter GPY07_RS13000 ENOG4105DSP amino acid AbC transporter GPY07_RS13005 ENOG4106YG3 ABC transporter GPY07_RS13010 ENOG4105CGK Exodeoxyribonuclease III GPY07_RS13015 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS13020 ENOG4106428 Protein of unknown function (DUF2496) GPY07_RS13025 ENOG4108URS primosomal replication protein n'' GPY07_RS13030 ENOG4105EJ9 Membrane GPY07_RS13035 ENOG4105DVT helicase GPY07_RS13040 ENOG4105ZU8 porin-like protein H GPY07_RS13055 ENOG4105D58 Diguanylate phosphodiesterase GPY07_RS13060 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GPY07_RS13065 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY07_RS13070 ENOG4105C8N cysteinyl-tRNA synthetase GPY07_RS13075 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GPY07_RS13080 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GPY07_RS13085 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GPY07_RS13090 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY07_RS13095 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY07_RS13105 ENOG4105KJB cyd operon protein YbgE GPY07_RS13110 ENOG4107YD3 Thioesterase GPY07_RS13115 ENOG4105E02 MotA TolQ exbB proton channel GPY07_RS13120 ENOG4105M8F Biopolymer transport protein exbD tolR GPY07_RS13130 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) GPY07_RS13135 ENOG4105KCK Peptidoglycan-associated lipoprotein GPY07_RS13155 ENOG4105BZU Histidine kinase GPY07_RS13160 ENOG4108RNS Exports L-alanine (By similarity) GPY07_RS13165 ENOG4105EIP mannose-6-phosphate isomerase GPY07_RS13170 ENOG4105DM4 PTS System GPY07_RS13175 ENOG4106R3P AraC family transcriptional regulator GPY07_RS13185 ENOG4108YRF PTS System GPY07_RS13190 ENOG4105DM4 PTS System GPY07_RS13195 ENOG4105DM4 PTS System GPY07_RS13205 ENOG4105C26 Dehydrogenase GPY07_RS13210 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GPY07_RS13215 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY07_RS13225 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY07_RS13345 ENOG4108NYK Tape measure protein GPY07_RS13360 ENOG4105DFP Integrase GPY07_RS13365 ENOG4105DFP Integrase GPY07_RS13390 ENOG4105DY2 Paraquat-inducible protein b GPY07_RS13420 ENOG4108R86 Transcriptional regulator GPY07_RS13425 ENOG4105C26 Dehydrogenase GPY07_RS13430 ENOG4105MTM Protein of unknown function (DUF1496) GPY07_RS13440 ENOG41067SE Tetr family transcriptional regulator GPY07_RS13445 ENOG4107QPN acyl-Coa dehydrogenase GPY07_RS13455 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GPY07_RS13460 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate GPY07_RS13465 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GPY07_RS13475 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GPY07_RS13480 ENOG4105RKX Protein of unknown function (DUF2498) GPY07_RS13485 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY07_RS13490 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY07_RS13495 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GPY07_RS13515 ENOG4105HP8 regulator of competence-specific genes GPY07_RS13520 ENOG4105ETE Transcriptional regulator (LacI family GPY07_RS13525 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPY07_RS13530 ENOG4106WF9 DNA-binding transcriptional regulator TorR GPY07_RS13535 ENOG4107S90 membrAne GPY07_RS13540 ENOG4106371 Methyltransferase GPY07_RS13545 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GPY07_RS13550 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GPY07_RS13555 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GPY07_RS13560 ENOG4105EW9 transcriptional regulator AsnC family GPY07_RS13570 ENOG4105CCT upf0313 protein GPY07_RS13575 ENOG4105BZU Histidine kinase GPY07_RS13595 ENOG4105DZ2 Transcriptional regulator GPY07_RS13600 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GPY07_RS13610 ENOG4105K9H YciI-like protein GPY07_RS13615 ENOG4105NAU thioesterase Superfamily protein GPY07_RS13620 ENOG4107835 probably involved in intracellular septation (By similarity) GPY07_RS13630 ENOG4105GFG DUF218 domain GPY07_RS13635 ENOG4108535 NAD dependent epimerase/dehydratase family GPY07_RS13645 ENOG4105TMB Formate nitrite transporter GPY07_RS13665 ENOG4107QY8 reductase GPY07_RS13685 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GPY07_RS13700 ENOG4108JQ2 peptide transport system atp-binding protein GPY07_RS13705 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GPY07_RS13710 ENOG4108EU3 peptide transport system, permease GPY07_RS13715 ENOG4108I5W peptide transport system, permease protein GPY07_RS13720 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY07_RS13725 ENOG4105E51 psp operon transcriptional activator GPY07_RS13730 ENOG41087YS Phage shock protein A GPY07_RS13745 ENOG4105C1P efflux transporter, rnd family, mfp subunit GPY07_RS13760 ENOG4108R3E Dna-3-methyladenine glycosylase i GPY07_RS13765 ENOG4105C28 cystathionine GPY07_RS13770 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GPY07_RS13775 ENOG4105C8J )-transporter GPY07_RS13780 ENOG4108W1A pseudouridine synthase GPY07_RS13785 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GPY07_RS13790 ENOG4108VGW abc transporter atp-binding protein GPY07_RS13800 ENOG4105VNH ABC transporter solute-binding protein GPY07_RS13810 ENOG4105XZD Fe-S protein GPY07_RS13820 ENOG4107QWP ABC-2 type transporter GPY07_RS13825 ENOG4105CJ1 ABC, transporter GPY07_RS13835 ENOG4105C44 Serine transporter GPY07_RS13845 ENOG4105CJW magnesium transporter GPY07_RS13850 ENOG4105BZU Histidine kinase GPY07_RS13855 ENOG4105BZU Histidine kinase GPY07_RS13865 ENOG4105KXC Collagenase GPY07_RS13895 ENOG4108N3W hemolysin secretion protein GPY07_RS13910 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GPY07_RS13930 ENOG4105CFI type iii restriction protein res subunit GPY07_RS13935 ENOG4105I08 Pseudouridine synthase GPY07_RS13940 ENOG4105C2C drug resistance transporter, Bcr CflA GPY07_RS13950 ENOG4105CGD Nad-dependent epimerase dehydratase GPY07_RS13955 ENOG4105UQX Mate efflux family protein GPY07_RS13960 ENOG4108I0Y (ABC) transporter GPY07_RS13975 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY07_RS13985 ENOG4105E3Q saccharopine dehydrogenase GPY07_RS13990 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) GPY07_RS13995 ENOG4105CDV Ompa motb domain protein GPY07_RS14000 ENOG4105DFG type I secretion outer membrane protein GPY07_RS14020 ENOG4105F04 LysR family Transcriptional regulator GPY07_RS14030 ENOG4108VKG metal-dependent hydrolase GPY07_RS14035 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GPY07_RS14045 ENOG41090FY type IV pilus biogenesis stability protein PilW GPY07_RS14050 ENOG4105CVG Homoserine O-transsuccinylase GPY07_RS14070 ENOG4107V40 secretion protein, HlyD family GPY07_RS14085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY07_RS14090 ENOG4106YYS transcriptional regulatory protein GPY07_RS14100 ENOG4107R88 Chemotaxis protein (CheV) GPY07_RS14120 ENOG4105BZU Histidine kinase GPY07_RS14145 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GPY07_RS14150 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GPY07_RS14155 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GPY07_RS14160 ENOG4106TD9 Diguanylate cyclase GPY07_RS14165 ENOG4105BZU Histidine kinase GPY07_RS14175 ENOG4105C7K acetolactate synthase GPY07_RS14180 ENOG4107FQX Alpha-acetolactate decarboxylase GPY07_RS14195 ENOG4105CH6 catalase GPY07_RS14205 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPY07_RS14215 ENOG4108TWJ NADH dehydrogenase subunit 5 GPY07_RS14220 ENOG4105DUM transcriptional regulator, lysR family GPY07_RS14225 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) GPY07_RS14255 ENOG4105C9Q fumarate hydratase class II GPY07_RS14265 ENOG4105E0M Sulfatase GPY07_RS14270 ENOG4107RE1 Inosine-guanosine kinase GPY07_RS14285 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY07_RS14325 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY07_RS14345 ENOG4105RKW reductase (By GPY07_RS14355 ENOG4108I0Y (ABC) transporter GPY07_RS14360 ENOG4105CV6 ABC transporter, permease GPY07_RS14365 ENOG4105C6Y Udp-glucose 6-dehydrogenase GPY07_RS14375 ENOG4107R7A Allophanate hydrolase subunit 2 GPY07_RS14385 ENOG4105E7W lamb ycsf family protein GPY07_RS14390 ENOG4105CMR udp-glucose 4-epimerase GPY07_RS14395 ENOG4108N3W hemolysin secretion protein GPY07_RS14400 ENOG4105E0U tyrosine-specific transport protein GPY07_RS14410 ENOG4108ZYK Acyl carrier protein phosphodiesterase GPY07_RS14415 ENOG4105C1J atp-dependent rna helicase GPY07_RS14420 ENOG4108IG5 Transcriptional regulator GPY07_RS14425 ENOG4106RE7 Cytochrome GPY07_RS14430 ENOG4105C5W Aldolase GPY07_RS14435 ENOG4108YZ4 nudix hydrolase GPY07_RS14445 ENOG4105EV2 VWA domain protein interacting with AAA ATPase GPY07_RS14455 ENOG4105E5Z arginine transporter ATP-binding subunit GPY07_RS14460 ENOG4106PMH Extracellular solute-binding protein family 3 GPY07_RS14465 ENOG4105GBT ABC transporter GPY07_RS14470 ENOG4105DMR ABC, transporter GPY07_RS14475 ENOG4105DUM transcriptional regulator, lysR family GPY07_RS14505 ENOG4105K63 Thioredoxin GPY07_RS14515 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GPY07_RS14520 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B GPY07_RS14525 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GPY07_RS14530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPY07_RS14535 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GPY07_RS14565 ENOG41082IR Excinuclease ABC C subunit domain protein GPY07_RS14575 ENOG4108QGH periplasmic GPY07_RS14580 ENOG4105BZU Histidine kinase GPY07_RS14625 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GPY07_RS14630 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GPY07_RS14635 ENOG4105E0C molybdate abc transporter GPY07_RS14640 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS14670 ENOG4105EM2 membrane GPY07_RS14675 ENOG41088T4 Helicase IV GPY07_RS14690 ENOG41080IJ Diacylglycerol kinase GPY07_RS14695 ENOG4108RWI nicotinamidase GPY07_RS14700 ENOG4108Z5K methylglyoxal synthase GPY07_RS14705 ENOG4108SV3 Tmao reductase system periplasmic protein tort GPY07_RS14710 ENOG4105BZU Histidine kinase GPY07_RS14715 ENOG4105CA9 Pyruvate kinase GPY07_RS14720 ENOG4105CXY transporter GPY07_RS14725 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GPY07_RS14735 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta GPY07_RS14745 ENOG4108I6A alcohol dehydrogenase GPY07_RS14755 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY07_RS14760 ENOG4105BZU Histidine kinase GPY07_RS14795 ENOG4108ZXE GPY07_RS14825 ENOG4108UK2 deaminase GPY07_RS14840 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY07_RS14845 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY07_RS14855 ENOG4105CHU acetyl-coa acetyltransferase GPY07_RS14865 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GPY07_RS14870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS14875 ENOG4107RCV ABC transporter, permease GPY07_RS14880 ENOG4105C4Y ABC transporter GPY07_RS14885 ENOG4105CXY transporter GPY07_RS14890 ENOG4105BZU Histidine kinase GPY07_RS14895 ENOG4108KX4 response regulator GPY07_RS14900 ENOG4105DHT Metal Dependent Phosphohydrolase GPY07_RS14920 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPY07_RS14935 ENOG4105BZU Histidine kinase GPY07_RS14940 ENOG4105WH1 Two component transcriptional regulator luxr family GPY07_RS14945 ENOG4105ETE Transcriptional regulator (LacI family GPY07_RS14965 ENOG4105EJQ L-serine dehydratase GPY07_RS14970 ENOG4105CEE C4-dicarboxylate transporter GPY07_RS14975 ENOG4108N3W hemolysin secretion protein GPY07_RS14980 ENOG4107VXZ Hydrolase GPY07_RS14985 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY07_RS14990 ENOG4108ZG0 Ompa motb domain protein GPY07_RS14995 ENOG4108NVR Methyl-accepting chemotaxis GPY07_RS15000 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GPY07_RS15005 ENOG4105D7K pfkb domain protein GPY07_RS15010 ENOG4107R3K hydrolase GPY07_RS15015 ENOG4105ETE Transcriptional regulator (LacI family GPY07_RS15020 ENOG4105C5Y PTS System GPY07_RS15065 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GPY07_RS15075 ENOG41080HT Transcriptional regulator, arsr family GPY07_RS15105 ENOG41067V3 Antibiotic biosynthesis monooxygenase GPY07_RS15110 ENOG4105ETT transcriptional Regulator, LysR family GPY07_RS15120 ENOG4105RA2 Membrane GPY07_RS15135 ENOG4108M3J Dehydrogenase GPY07_RS15160 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY07_RS15165 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPY07_RS15175 ENOG4107RHR regulatoR GPY07_RS15180 ENOG4105KHC sulfurtransferase GPY07_RS15190 ENOG4105D06 uba thif-type nad fad binding protein GPY07_RS15195 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY07_RS15200 ENOG4105EUJ GTP cyclohydrolase i GPY07_RS15205 ENOG4105E0X reductase GPY07_RS15210 ENOG4105CKU formyltetrahydrofolate synthetase GPY07_RS15215 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GPY07_RS15220 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GPY07_RS15230 ENOG4105PAD Hydrolase GPY07_RS15235 ENOG4105NXH GreA GreB family elongation factor GPY07_RS15240 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GPY07_RS15245 ENOG4108JPW Aminotransferase GPY07_RS15250 ENOG4107STF Involved in phosphonate degradation (By similarity) GPY07_RS15265 ENOG4107RCV ABC transporter, permease GPY07_RS15280 ENOG4105DUX Transporter GPY07_RS15305 ENOG4105E43 Extracellular solute-binding protein, family 5 GPY07_RS15310 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GPY07_RS15315 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPY07_RS15320 ENOG4108JQ5 ABC transporter GPY07_RS15325 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPY07_RS15340 ENOG4105CYM Glutathione S-transferase GPY07_RS15360 ENOG4105KA0 thioesterase Superfamily protein GPY07_RS15380 ENOG4105CWB LysR family transcriptional Regulator GPY07_RS15385 ENOG4105CD5 CoA-binding domain protein GPY07_RS15395 ENOG4105CPF Cell wall formation (By similarity) GPY07_RS15405 ENOG4108ZJT translation initiation factor, Sui1 GPY07_RS15425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY07_RS15435 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY07_RS15440 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY07_RS15455 ENOG4105BZU Histidine kinase GPY07_RS15465 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GPY07_RS15475 ENOG4105BZU Histidine kinase GPY07_RS15510 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GPY07_RS15525 ENOG4105DU1 integral membrane protein, terc GPY07_RS15530 ENOG4105CGH 5'-nucleotidase GPY07_RS15535 ENOG4105CPB ATP-dependent endonuclease of the OLD family GPY07_RS15540 ENOG4108UQ5 membrane protein YcdZ GPY07_RS15545 ENOG4105DUM transcriptional regulator, lysR family GPY07_RS15550 ENOG4105TMB Formate nitrite transporter GPY07_RS15560 ENOG4105DS1 cytochrome b561 GPY07_RS15570 ENOG4105EPM Diguanylate phosphodiesterase GPY07_RS15580 ENOG4108RHM integral membrane protein GPY07_RS15585 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) GPY07_RS15590 ENOG4105EEX Two component transcriptional regulator (Winged helix family GPY07_RS15595 ENOG4105C08 Histidine kinase GPY07_RS15600 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GPY07_RS15605 ENOG4105DFH Transport of potassium into the cell (By similarity) GPY07_RS15610 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GPY07_RS15615 ENOG4105CKI cobalamin synthesis protein GPY07_RS15630 ENOG4107KBT 8-Amino-7-oxononanoate synthase GPY07_RS15635 ENOG4108MGY Histidine kinase GPY07_RS15640 ENOG4105EYH Exonuclease GPY07_RS15645 ENOG4107RFY SbcCD D subunit GPY07_RS15650 ENOG4107B7Y DNA-binding transcriptional regulator FruR GPY07_RS15655 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GPY07_RS15660 ENOG4105DE4 1-phosphofructokinase GPY07_RS15665 ENOG4105DM4 PTS System GPY07_RS15670 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY07_RS15675 ENOG4105CGF Aromatic amino acid aminotransferase GPY07_RS15680 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GPY07_RS15685 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GPY07_RS15710 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY07_RS15775 ENOG4108RS6 transposase GPY07_RS15870 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY07_RS15890 ENOG4105EQK -acetyltransferase GPY07_RS15895 ENOG4105F2I Transposase GPY07_RS15910 ENOG4105W08 virulence gene repressor rsal GPY07_RS15915 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system GPY07_RS15955 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY07_RS16070 ENOG4105QNF Outer membrane lipoprotein GPY07_RS16095 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GPY07_RS16115 ENOG4105VDM plasmid maintenance system antidote protein, xre family GPY07_RS16120 ENOG41080ET plasmid maintenance system killer protein GPY07_RS16325 ENOG4105N14 lysine exporter protein LysE YggA GPY07_RS16335 ENOG4105YGK Pfam:UPF0157 GPY07_RS16395 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY07_RS16420 ENOG4105VXN addiction module toxin, RelE StbE family GPY07_RS16455 ENOG4105QNF Outer membrane lipoprotein GPY07_RS16460 ENOG4105D9U N-acetyltransferase GPY07_RS16510 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GPY07_RS16545 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GPY07_RS16605 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GPY07_RS16610 ENOG41082NX 50s ribosomal protein l35 GPY07_RS16615 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GPY07_RS16620 ENOG4105C22 threonyL-tRNA synthetase GPY07_RS16645 ENOG4105F2I Transposase GPY07_RS16655 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GPY07_RS16665 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY07_RS16670 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GPY07_RS16675 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GPY07_RS16685 ENOG4108RS6 transposase GPY07_RS16705 ENOG4105DZ1 carboxypeptidase GPY07_RS16715 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS16720 ENOG4105C2C drug resistance transporter, Bcr CflA GPY07_RS16735 ENOG4107QVI Methyltransferase, type 11 GPY07_RS16760 ENOG4105BZU Histidine kinase GPY07_RS16765 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPY07_RS16795 ENOG4105DS1 cytochrome b561 GPY07_RS16825 ENOG410667J hydrolase GPY07_RS16835 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase GPY07_RS16845 ENOG4105ETX regulatoR GPY07_RS16865 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY07_RS16885 ENOG4108IPW abc transporter atp-binding protein GPY07_RS16890 ENOG4105CM4 permease protein GPY07_RS16895 ENOG4105DHS permease protein GPY07_RS16915 ENOG4107G87 m6 family metalloprotease domain protein GPY07_RS16925 ENOG4107IFA Lipase (EC 3.1.1.3) GPY07_RS16930 ENOG4108N3W hemolysin secretion protein GPY07_RS16935 ENOG4106M3D hemolysin GPY07_RS16940 ENOG4105KUU lipolytic protein G-D-S-L family GPY07_RS16945 ENOG4105BZU Histidine kinase GPY07_RS16955 ENOG4105E5M Multidrug resistance protein D GPY07_RS16960 ENOG4107S6Z Na H antiporter GPY07_RS16970 ENOG4105BZU Histidine kinase GPY07_RS16975 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY07_RS16985 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GPY07_RS16990 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GPY07_RS16995 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY07_RS17000 ENOG4105C1J atp-dependent rna helicase GPY07_RS17015 ENOG4108RS6 transposase GPY07_RS17040 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY07_RS17060 ENOG4105C5I Dehydrogenase GPY07_RS17065 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GPY07_RS17075 ENOG4108UNF response regulator GPY07_RS17095 ENOG4105VEQ Cold shock protein GPY07_RS17100 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPY07_RS17105 ENOG4108JUA Transcriptional regulator GPY07_RS17115 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY07_RS17120 ENOG4105D9N nucleoside GPY07_RS17135 ENOG41069D7 Methyl-accepting chemotaxis GPY07_RS17140 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GPY07_RS17175 ENOG4105VEQ Cold shock protein GPY07_RS17180 ENOG4105BZU Histidine kinase GPY07_RS17190 ENOG4105VRT cytoplasmic protein GPY07_RS17200 ENOG4105C0F tryptophanase EC 4.1.99.1 GPY07_RS17205 ENOG4105CIC tryptophan-specific transport protein GPY07_RS17210 ENOG4105Q9Y Universal stress protein GPY07_RS17220 ENOG4105D65 subunit l GPY07_RS17225 ENOG4105MKQ Monovalent cation H antiporter subunit C GPY07_RS17230 ENOG4108JPZ Monovalent cation H antiporter subunit D GPY07_RS17235 ENOG4105SC1 monovalent cation H antiporter subunit E GPY07_RS17240 ENOG41080TA Multiple resistance and ph regulation protein f GPY07_RS17245 ENOG4105KJM monovalent cation h antiporter subunit g GPY07_RS17255 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY07_RS17265 ENOG4105D5U fad dependent oxidoreductase GPY07_RS17285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY07_RS17290 ENOG4105CQZ Histidine kinase GPY07_RS17305 ENOG4105CXY transporter GPY07_RS17310 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPY07_RS17320 ENOG4108I5U Uridine phosphorylase GPY07_RS17330 ENOG4105ETE Transcriptional regulator (LacI family GPY07_RS17335 ENOG4108RVA ribokinase GPY07_RS17340 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPY07_RS17345 ENOG4105CNN ABC, transporter GPY07_RS17350 ENOG4105C2J ABC transporter GPY07_RS17355 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GPY07_RS17370 ENOG4105CS6 Rhs element vgr protein GPY07_RS17400 ENOG4108JUB Transcriptional regulator GPY07_RS17405 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY07_RS17465 ENOG4105D3G Pseudouridine synthase GPY07_RS17475 ENOG4107VXZ Hydrolase GPY07_RS17480 ENOG4105BZU Histidine kinase GPY07_RS17490 ENOG4105D9R oxidoreductase GPY07_RS17495 ENOG4107RH7 Nicotinate phosphoribosyltransferase GPY07_RS17535 ENOG4105CK2 sodium dicarboxylate symporter GPY07_RS17555 ENOG4108Z4X TRANSCRIPTIONal GPY07_RS17560 ENOG4105E5M Multidrug resistance protein D GPY07_RS17565 ENOG4105EQ2 LysR family Transcriptional regulator GPY07_RS17570 ENOG4105BZU Histidine kinase GPY07_RS17575 ENOG4105DR5 peptidase GPY07_RS17585 ENOG4105CHH sulfate transporter GPY07_RS17590 ENOG4105DWD nucleoside recognition domain protein GPY07_RS17600 ENOG4105BZU Histidine kinase GPY07_RS17605 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS17610 ENOG4105E2Z phosphate ABC transporter (Permease GPY07_RS17615 ENOG4105C8U phosphate abc transporter GPY07_RS17620 ENOG4105CVA phosphate GPY07_RS17650 ENOG4105CUG Oligopeptidase b GPY07_RS17655 ENOG4105C1J atp-dependent rna helicase GPY07_RS17665 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPY07_RS17670 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY07_RS17680 ENOG4107SEY Conserved Protein GPY07_RS17685 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY07_RS17700 ENOG4106TD9 Diguanylate cyclase GPY07_RS17705 ENOG4105KK7 inner membrane protein YiaW GPY07_RS17710 ENOG4105EFX secretion protein, HlyD family GPY07_RS17725 ENOG4105YE1 PilZ domain GPY07_RS17730 ENOG4105D6U Sodium Glutamate Symporter GPY07_RS17755 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GPY07_RS17760 ENOG4105EYK Phosphatidylglycerophosphatase B GPY07_RS17780 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS17805 ENOG4108Q67 UPF0319 protein GPY07_RS17810 ENOG4105C8P )-transporter GPY07_RS17820 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY07_RS17845 ENOG4105CS6 Rhs element vgr protein GPY07_RS17850 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY07_RS17855 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GPY07_RS17860 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GPY07_RS17865 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GPY07_RS17870 ENOG41061ZR Transcriptional regulator GPY07_RS17875 ENOG4108YYI Protein of unknown function (DUF2810) GPY07_RS17885 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS17890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY07_RS17895 ENOG4105CDY transcriptional regulatory protein GPY07_RS17925 ENOG4106RMF ParB family GPY07_RS17930 ENOG4107RUE extracellular solute-binding protein family 1 GPY07_RS17935 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GPY07_RS17965 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPY07_RS17970 ENOG4105DHQ Histidine kinase GPY07_RS17975 ENOG4105DIJ Phosphoethanolamine transferase GPY07_RS17980 ENOG4108JQ6 ABC transporter GPY07_RS17985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY07_RS17990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY07_RS18005 ENOG4108VYJ response regulator receiver protein GPY07_RS18010 ENOG4105CBS Chea signal transduction histidine kinase GPY07_RS18015 ENOG4108V3W Chemotaxis protein, CheW GPY07_RS18020 ENOG4108V3W Chemotaxis protein, CheW GPY07_RS18025 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS18030 ENOG4105BZU Histidine kinase GPY07_RS18035 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GPY07_RS18040 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY07_RS18045 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS18055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY07_RS18065 ENOG4108JJA ABC, transporter GPY07_RS18080 ENOG4107QZV Type I secretion membrane fusion protein GPY07_RS18085 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GPY07_RS18095 ENOG4105E6M Sulphatase-modifying factor protein GPY07_RS18110 ENOG4105C26 Dehydrogenase GPY07_RS18120 ENOG4105CK7 Sodium proline symporter GPY07_RS18130 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS18135 ENOG4105EW9 transcriptional regulator AsnC family GPY07_RS18140 ENOG4107RGH Aldehyde dehydrogenase GPY07_RS18150 ENOG4105CXN decarboxylase GPY07_RS18155 ENOG4105D5Q Arginine ornithine antiporter GPY07_RS18165 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GPY07_RS18175 ENOG4105JQN Transcriptional regulator GPY07_RS18180 ENOG4105EMU Dehydrogenase GPY07_RS18185 ENOG41069D7 Methyl-accepting chemotaxis GPY07_RS18190 ENOG4105JQN Transcriptional regulator GPY07_RS18195 ENOG4108RYK Nad-dependent epimerase dehydratase GPY07_RS18225 ENOG4105EP9 oxidoreductase GPY07_RS18230 ENOG4105E61 Mannitol repressor protein GPY07_RS18235 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GPY07_RS18240 ENOG4105CTS PTS system mannitol-specific GPY07_RS18250 ENOG4105DR5 peptidase GPY07_RS18260 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GPY07_RS18265 ENOG4105EZ7 amino acid ABC transporter GPY07_RS18270 ENOG4106TNF Periplasmic binding protein GPY07_RS18280 ENOG4105CDA abc transporter atp-binding protein GPY07_RS18285 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY07_RS18295 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS18310 ENOG4108N3W hemolysin secretion protein GPY07_RS18325 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GPY07_RS18330 ENOG4107W52 maltose operon periplasmic protein GPY07_RS18340 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GPY07_RS18365 ENOG4108VGI doxx family GPY07_RS18370 ENOG4105D03 DNA-3-methyladenine glycosylase II GPY07_RS18375 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GPY07_RS18385 ENOG4105DN9 Na H antiporter GPY07_RS18390 ENOG41074DU domain protein GPY07_RS18395 ENOG4108P2H Inner membrane protein YjiG GPY07_RS18400 ENOG4105VW4 glutaredoxin 3 GPY07_RS18405 ENOG4108SXK Transporter Drug Metabolite Exporter family GPY07_RS18415 ENOG4108ZHJ Organic hydroperoxide resistance protein GPY07_RS18420 ENOG4105K56 Transcriptional regulator GPY07_RS18455 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY07_RS18465 ENOG4105BZ1 (ABC) transporter GPY07_RS18475 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY07_RS18485 ENOG4105CR8 Transcriptional regulator GPY07_RS18490 ENOG4105C1J atp-dependent rna helicase GPY07_RS18500 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GPY07_RS18510 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GPY07_RS18520 ENOG4105DMF Dehydrogenase GPY07_RS18525 ENOG4105DAA L-lactate GPY07_RS18530 ENOG4105CC0 LysR family Transcriptional regulator GPY07_RS18545 ENOG4107SDU Methyl-accepting chemotaxis GPY07_RS18550 ENOG4105E89 ABC transporter GPY07_RS18555 ENOG4108JQ5 ABC transporter GPY07_RS18565 ENOG4105DAN ATP-dependent protease GPY07_RS18570 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS18580 ENOG4105E5W Transporter GPY07_RS18590 ENOG4105NBK UPF0345 protein GPY07_RS18595 ENOG4105EUB pirin domain protein GPY07_RS18605 ENOG4108K0B C-di-gmp phosphodiesterase GPY07_RS18610 ENOG4105ETT transcriptional Regulator, LysR family GPY07_RS18630 ENOG4105BZU Histidine kinase GPY07_RS18645 ENOG4106TD9 Diguanylate cyclase GPY07_RS18650 ENOG4105K56 Transcriptional regulator GPY07_RS18655 ENOG4107R88 Chemotaxis protein (CheV) GPY07_RS18660 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GPY07_RS18665 ENOG41086KC Transcriptional regulator GPY07_RS18670 ENOG4105K8R UPF0145 protein GPY07_RS18685 ENOG4108HK0 -acetyltransferase GPY07_RS18690 ENOG4108IJ9 (ABC) transporter GPY07_RS18695 ENOG4107FKK extracellular solute-binding protein family 1 GPY07_RS18700 ENOG4105D56 permease protein GPY07_RS18705 ENOG4105EG2 ABC transporter, permease GPY07_RS18720 ENOG4105E98 transcriptional regulator DeoR family GPY07_RS18725 ENOG4105BZU Histidine kinase GPY07_RS18735 ENOG4105EQD regulatoR GPY07_RS18750 ENOG4105VEQ Cold shock protein GPY07_RS18755 ENOG4108ESY Metal dependent phosphohydrolase GPY07_RS18760 ENOG4105CKW Inner membrane protein yedI GPY07_RS18765 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GPY07_RS18775 ENOG4105KAF membrAne GPY07_RS18785 ENOG4105EKE dihydroorotase GPY07_RS18790 ENOG4105QVC MOSC domain-containing protein GPY07_RS18790 ENOG4105QVC MOSC domain-containing protein GPY07_RS18795 ENOG4105C8Q Methyl-accepting chemotaxis GPY07_RS18825 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GPY07_RS18830 ENOG4105EHG Permease protein GPY07_RS18835 ENOG4107R4I Periplasmic binding protein GPY07_RS18840 ENOG4106GFD transport protein GPY07_RS18845 ENOG41090AP transport protein GPY07_RS18850 ENOG4105WQ5 TonB family GPY07_RS18855 ENOG4105D4P Coproporphyrinogen iii oxidase GPY07_RS18860 ENOG41090JE Utilization Protein GPY07_RS18865 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related GPY07_RS18870 ENOG4108NVR Methyl-accepting chemotaxis GPY07_RS18875 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GPY07_RS18880 ENOG4105C6Z Gluconate GPY07_RS18885 ENOG4105BZW Glycerate kinase GPY07_RS18910 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GPY07_RS18915 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) GPY07_RS18920 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GPY07_RS18930 ENOG4107SSZ Phosphatase GPY07_RS18950 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GPY07_RS18955 ENOG4105EXG Transcriptional regulator GPY07_RS18970 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY07_RS18975 ENOG4105CPQ Dehydrogenase GPY07_RS19020 ENOG4105W8I Transcriptional regulator GPY07_RS19025 ENOG4105BZC d-serine deaminase GPY07_RS19040 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY07_RS19045 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY07_RS19050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY07_RS19055 ENOG41061WM D-Alanyl-D-Alanine GPY07_RS19065 ENOG4105EIF outer membrane protein W GPY07_RS19075 ENOG4105D4Y metalloprotease GPY07_RS19080 ENOG4107SDU Methyl-accepting chemotaxis GPY07_RS19085 ENOG4108M0H Extracellular lipase GPY07_RS19090 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY07_RS19100 ENOG4107T9C Alpha amylase catalytic region GPY07_RS19105 ENOG4107RGM aldo keto reductase GPY07_RS19120 ENOG4105C19 ABC transporter GPY07_RS19125 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY07_RS19140 ENOG4108HRK Histidine kinase GPY07_RS19145 ENOG4108VAC response regulator GPY07_RS19155 ENOG4106TD9 Diguanylate cyclase GPY07_RS19160 ENOG4105DVH amino acid GPY07_RS19180 ENOG4107YWA deoxycytidylate deaminase GPY07_RS19185 ENOG4108UKZ OsmC family GPY07_RS19190 ENOG4105C37 (CBS) domain GPY07_RS19195 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GPY07_RS19210 ENOG4105EGI Transcriptional regulator GPY07_RS19215 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY07_RS19230 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY07_RS19235 ENOG4105MIR Phenylalanine 4-monooxygenase GPY07_RS19240 ENOG41090A4 Pterin carbinolamine dehydratase GPY07_RS19245 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GPY07_RS19250 ENOG4108JPW Aminotransferase GPY07_RS19255 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GPY07_RS19260 ENOG4105CZK Aspartate kinase GPY07_RS19270 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY07_RS19275 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY07_RS19280 ENOG4105CJW magnesium transporter GPY07_RS19295 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GPY07_RS19300 ENOG4105CYW agmatinase GPY07_RS19310 ENOG4105D4Y metalloprotease GPY07_RS19315 ENOG4108M1A Chitin-binding protein GPY07_RS19320 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GPY07_RS19330 ENOG4105CVA phosphate GPY07_RS19340 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GPY07_RS19345 ENOG4105C1J atp-dependent rna helicase