locus-tag	class	description
A6J62_RS00010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J62_RS00015	COG2771	luxR family
A6J62_RS00015	COG2200	EAL domain
A6J62_RS00025	COG0673	inositol 2-dehydrogenase activity
A6J62_RS00030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J62_RS00065	COG1342	Belongs to the UPF0251 family
A6J62_RS00075	COG1301	dicarboxylic acid transport
A6J62_RS00100	COG2814	Major facilitator Superfamily
A6J62_RS00105	COG0583	DNA-binding transcription factor activity
A6J62_RS00110	COG3300	MHYT domain
A6J62_RS00110	COG5001	Diguanylate cyclase
A6J62_RS00115	COG0739	heme binding
A6J62_RS00125	COG0659	secondary active sulfate transmembrane transporter activity
A6J62_RS00130	COG3314	Sporulation integral membrane protein YlbJ
A6J62_RS00150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J62_RS00155	COG0581	inorganic phosphate transmembrane transporter activity
A6J62_RS00160	COG0573	inorganic phosphate transmembrane transporter activity
A6J62_RS00165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J62_RS00195	COG1770	oligopeptidase
A6J62_RS00200	COG0513	Belongs to the DEAD box helicase family
A6J62_RS00210	COG1388	LysM domain
A6J62_RS00210	COG1376	ErfK ybiS ycfS ynhG family protein
A6J62_RS00215	COG0415	Belongs to the DNA photolyase family
A6J62_RS00225	COG3272	Protein of unknown function (DUF1722)
A6J62_RS00235	COG0813	purine-nucleoside phosphorylase activity
A6J62_RS00260	COG1566	PFAM secretion protein HlyD family protein
A6J62_RS00280	COG0786	glutamate:sodium symporter activity
A6J62_RS00295	COG1999	signal sequence binding
A6J62_RS00305	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6J62_RS00310	COG0671	phosphoesterase, PA-phosphatase related
A6J62_RS00355	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6J62_RS00360	COG0471	metal ion transport
A6J62_RS00390	COG4104	PAAR repeat-containing protein
A6J62_RS00395	COG3501	Rhs element vgr protein
A6J62_RS00410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J62_RS00415	COG1640	4-alpha-glucanotransferase
A6J62_RS00420	COG0058	SHG alpha-glucan phosphorylase activity
A6J62_RS00425	COG2909	trisaccharide binding
A6J62_RS00445	COG2084	Dehydrogenase
A6J62_RS00450	COG0217	transcriptional regulatory protein
A6J62_RS00490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6J62_RS00495	COG1444	tRNA N-acetyltransferase activity
A6J62_RS00530	COG0642	Histidine kinase
A6J62_RS00545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J62_RS00550	COG0601	transmembrane transport
A6J62_RS00570	COG0643	Histidine kinase
A6J62_RS00570	COG2198	Histidine kinase
A6J62_RS00575	COG0835	chemotaxis
A6J62_RS00580	COG0835	chemotaxis
A6J62_RS00585	COG0840	transmembrane signaling receptor activity
A6J62_RS00590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J62_RS00615	COG0745	RESPONSE REGULATOR receiver
A6J62_RS00655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6J62_RS00680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J62_RS00715	COG1982	Orn Lys Arg decarboxylase major
A6J62_RS00720	COG0531	amino acid
A6J62_RS00735	COG1901	pseudouridine methyltransferase
A6J62_RS00745	COG4221	oxidoreductase activity
A6J62_RS00750	COG0840	transmembrane signaling receptor activity
A6J62_RS00760	COG2910	NAD(P)H-binding
A6J62_RS00790	COG0673	inositol 2-dehydrogenase activity
A6J62_RS00795	COG3722	fumarate hydratase activity
A6J62_RS00800	COG0246	Mannitol dehydrogenase
A6J62_RS00805	COG2213	PTS system mannitol-specific
A6J62_RS00805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J62_RS00825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J62_RS00830	COG4597	amino acid ABC transporter
A6J62_RS00835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J62_RS00845	COG1126	abc transporter atp-binding protein
A6J62_RS00850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J62_RS00860	COG0840	transmembrane signaling receptor activity
A6J62_RS00875	COG0840	transmembrane signaling receptor activity
A6J62_RS00890	COG4580	involved in the transport of maltose and maltodextrins
A6J62_RS00905	COG0363	glucosamine-6-phosphate deaminase activity
A6J62_RS00930	COG2259	Doxx family
A6J62_RS00935	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6J62_RS00940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J62_RS00950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6J62_RS00955	COG3366	ferrous iron transmembrane transporter activity
A6J62_RS00960	COG0700	Nucleoside recognition
A6J62_RS00970	COG0697	spore germination
A6J62_RS00975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6J62_RS00980	COG1764	response to oxidative stress
A6J62_RS00985	COG1846	Transcriptional regulator
A6J62_RS01005	COG2207	Transcriptional regulator
A6J62_RS01010	COG1280	lysine exporter protein (LysE YggA)
A6J62_RS01020	COG1902	pentaerythritol trinitrate reductase activity
A6J62_RS01030	COG1132	(ABC) transporter
A6J62_RS01040	COG1902	pentaerythritol trinitrate reductase activity
A6J62_RS01050	COG0583	DNA-binding transcription factor activity
A6J62_RS01055	COG0513	Belongs to the DEAD box helicase family
A6J62_RS01065	COG0840	transmembrane signaling receptor activity
A6J62_RS01075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6J62_RS01090	COG1620	l-lactate permease
A6J62_RS01095	COG0583	DNA-binding transcription factor activity
A6J62_RS01120	COG4172	Belongs to the ABC transporter superfamily
A6J62_RS01130	COG1067	ATP-dependent peptidase activity
A6J62_RS01135	COG0840	transmembrane signaling receptor activity
A6J62_RS01145	COG2211	Major facilitator Superfamily
A6J62_RS01155	COG3123	guanosine phosphorylase activity
A6J62_RS01160	COG1741	Belongs to the pirin family
A6J62_RS01170	COG5001	Diguanylate cyclase
A6J62_RS01175	COG0583	DNA-binding transcription factor activity
A6J62_RS01220	COG1846	Transcriptional regulator
A6J62_RS01225	COG0784	Response regulator, receiver
A6J62_RS01225	COG0835	chemotaxis
A6J62_RS01230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J62_RS01240	COG0393	Putative heavy-metal-binding
A6J62_RS01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J62_RS01260	COG3842	ATPase activity
A6J62_RS01270	COG1175	transmembrane transport
A6J62_RS01275	COG3833	ABC-type maltose transport systems, permease component
A6J62_RS01290	COG1349	DNA-binding transcription factor activity
A6J62_RS01295	COG2199	diguanylate cyclase activity
A6J62_RS01325	COG1278	Cold shock
A6J62_RS01330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6J62_RS01335	COG2354	Protein conserved in bacteria
A6J62_RS01340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J62_RS01350	COG3152	Membrane
A6J62_RS01360	COG0418	dihydroorotase activity
A6J62_RS01365	COG0633	Ferredoxin
A6J62_RS01365	COG0633	Ferredoxin
A6J62_RS01365	COG3217	Mosc domain protein beta barrel domain protein
A6J62_RS01365	COG3217	Mosc domain protein beta barrel domain protein
A6J62_RS01400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6J62_RS01405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J62_RS01410	COG4558	Periplasmic binding protein
A6J62_RS01415	COG0848	biopolymer transport protein
A6J62_RS01420	COG0811	peptide transport
A6J62_RS01425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6J62_RS01435	COG3721	Heme iron utilization protein
A6J62_RS01440	COG0748	coenzyme F420 binding
A6J62_RS01450	COG3835	regulator
A6J62_RS01455	COG2610	gluconate transmembrane transporter activity
A6J62_RS01485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6J62_RS01495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J62_RS01505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6J62_RS01525	COG0346	lactoylglutathione lyase activity
A6J62_RS01555	COG1063	alcohol dehydrogenase
A6J62_RS01605	COG0583	DNA-binding transcription factor activity
A6J62_RS01610	COG3048	D-serine ammonia-lyase activity
A6J62_RS01625	COG1294	oxidase, subunit
A6J62_RS01630	COG1271	oxidase subunit
A6J62_RS01635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J62_RS01640	COG1686	Belongs to the peptidase S11 family
A6J62_RS01650	COG3047	cAMP biosynthetic process
A6J62_RS01660	COG3227	Zinc metalloprotease (Elastase)
A6J62_RS01670	COG2267	carboxylic ester hydrolase activity
A6J62_RS01675	COG2067	long-chain fatty acid transport protein
A6J62_RS01685	COG0366	Alpha amylase catalytic
A6J62_RS01690	COG4989	oxidoreductase activity
A6J62_RS01705	COG1136	(ABC) transporter
A6J62_RS01725	COG3275	phosphorelay sensor kinase activity
A6J62_RS01730	COG3279	Response regulator of the LytR AlgR family
A6J62_RS01745	COG0531	amino acid
A6J62_RS01770	COG1765	OsmC-like protein
A6J62_RS01775	COG1253	flavin adenine dinucleotide binding
A6J62_RS01800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J62_RS01820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J62_RS01835	COG0456	acetyltransferase
A6J62_RS01840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J62_RS01845	COG0662	Cupin 2, conserved barrel domain protein
A6J62_RS01850	COG0527	aspartate kinase activity
A6J62_RS01860	COG0459	protein refolding
A6J62_RS01865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J62_RS01880	COG1166	arginine decarboxylase activity
A6J62_RS01885	COG0010	Belongs to the arginase family
A6J62_RS01895	COG3227	Zinc metalloprotease (Elastase)
A6J62_RS01900	COG3397	chitin binding
A6J62_RS01905	COG3046	protein related to deoxyribodipyrimidine photolyase
A6J62_RS01915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J62_RS01930	COG0513	Belongs to the DEAD box helicase family
A6J62_RS01940	COG1368	sulfuric ester hydrolase activity
A6J62_RS01945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J62_RS01960	COG0546	phosphoglycolate phosphatase activity
A6J62_RS02000	COG0484	heat shock protein binding
A6J62_RS02015	COG5001	Diguanylate cyclase
A6J62_RS02015	COG1716	ATPase activity
A6J62_RS02020	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J62_RS02030	COG4181	ATPase activity
A6J62_RS02035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6J62_RS02050	COG1984	allophanate hydrolase subunit 2
A6J62_RS02060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6J62_RS02070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J62_RS02075	COG0840	transmembrane signaling receptor activity
A6J62_RS02080	COG0814	amino acid
A6J62_RS02090	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6J62_RS02095	COG0513	Belongs to the DEAD box helicase family
A6J62_RS02100	COG1309	transcriptional regulator
A6J62_RS02110	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A6J62_RS02115	COG0494	nUDIX hydrolase
A6J62_RS02125	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A6J62_RS02135	COG1126	abc transporter atp-binding protein
A6J62_RS02140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J62_RS02145	COG4215	(ABC) transporter
A6J62_RS02150	COG4160	amino acid transport
A6J62_RS02155	COG0583	DNA-binding transcription factor activity
A6J62_RS02185	COG3118	belongs to the thioredoxin family
A6J62_RS02190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J62_RS02195	COG0247	lactate metabolic process
A6J62_RS02200	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A6J62_RS02205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J62_RS02210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J62_RS02215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6J62_RS02230	COG2926	Belongs to the UPF0265 family
A6J62_RS02245	COG2827	Endonuclease containing a URI domain
A6J62_RS02255	COG1879	ABC-type sugar transport system periplasmic component
A6J62_RS02260	COG5002	protein histidine kinase activity
A6J62_RS02260	COG0784	Response regulator, receiver
A6J62_RS02305	COG1492	cobalamin metabolic process
A6J62_RS02310	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6J62_RS02315	COG4149	molybdate abc transporter
A6J62_RS02320	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6J62_RS02350	COG1289	transmembrane transporter activity
A6J62_RS02355	COG0210	DNA helicase
A6J62_RS02370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J62_RS02375	COG1335	isochorismatase
A6J62_RS02380	COG1803	Methylglyoxal synthase
A6J62_RS02385	COG1879	ABC-type sugar transport system periplasmic component
A6J62_RS02390	COG2205	protein histidine kinase activity
A6J62_RS02390	COG2198	Histidine kinase
A6J62_RS02390	COG0784	Response regulator, receiver
A6J62_RS02400	COG2271	Major facilitator Superfamily
A6J62_RS02410	COG4191	Histidine kinase
A6J62_RS02425	COG1979	alcohol dehydrogenase
A6J62_RS02440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J62_RS02460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J62_RS02465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J62_RS02475	COG0183	Belongs to the thiolase family
A6J62_RS02490	COG3842	ATPase activity
A6J62_RS02500	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J62_RS02505	COG2271	Major facilitator Superfamily
A6J62_RS02510	COG3851	Histidine kinase
A6J62_RS02515	COG2197	response regulator
A6J62_RS02520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6J62_RS02540	COG0243	molybdopterin cofactor binding
A6J62_RS02550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J62_RS02555	COG3850	Histidine kinase
A6J62_RS02560	COG2197	response regulator
A6J62_RS02565	COG1609	Transcriptional regulator
A6J62_RS02585	COG1760	l-serine dehydratase
A6J62_RS02590	COG3069	C4-dicarboxylate transmembrane transporter activity
A6J62_RS02600	COG0840	transmembrane signaling receptor activity
A6J62_RS02605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J62_RS02610	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J62_RS02615	COG2885	chlorophyll binding
A6J62_RS02625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J62_RS02630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J62_RS02635	COG1621	beta-fructofuranosidase activity
A6J62_RS02640	COG1609	Transcriptional regulator
A6J62_RS02645	COG1263	PTS System
A6J62_RS02645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J62_RS02690	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J62_RS02735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A6J62_RS02740	COG0583	DNA-binding transcription factor activity
A6J62_RS02765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J62_RS02790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J62_RS02805	COG2390	Transcriptional regulator
A6J62_RS02810	COG2897	thiosulfate sulfurtransferase activity
A6J62_RS02820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J62_RS02830	COG0302	gtp cyclohydrolase
A6J62_RS02835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J62_RS02835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J62_RS02840	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J62_RS02845	COG1970	mechanosensitive ion channel activity
A6J62_RS02850	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6J62_RS02860	COG1011	Hydrolase
A6J62_RS02865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J62_RS02870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J62_RS02875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J62_RS02880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6J62_RS02890	COG3842	ATPase activity
A6J62_RS02910	COG3104	oligopeptide transport
A6J62_RS02935	COG4166	transmembrane transport
A6J62_RS02940	COG4174	ABC transporter (Permease)
A6J62_RS02945	COG4239	(ABC) transporter, permease
A6J62_RS02950	COG4172	Belongs to the ABC transporter superfamily
A6J62_RS02955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J62_RS02970	COG0625	glutathione transferase activity
A6J62_RS02995	COG2050	protein possibly involved in aromatic compounds catabolism
A6J62_RS03015	COG4771	TonB-dependent receptor
A6J62_RS03015	COG1629	transport
A6J62_RS03020	COG0583	DNA-binding transcription factor activity
A6J62_RS03025	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J62_RS03025	COG1042	CoA-binding domain protein
A6J62_RS03025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J62_RS03045	COG0023	Translation Initiation Factor
A6J62_RS03050	COG3140	Belongs to the UPF0181 family
A6J62_RS03065	COG0745	RESPONSE REGULATOR receiver
A6J62_RS03075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6J62_RS03080	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6J62_RS03095	COG3706	GGDEF domain
A6J62_RS03115	COG2199	diguanylate cyclase activity
A6J62_RS03150	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J62_RS03165	COG0737	Belongs to the 5'-nucleotidase family
A6J62_RS03170	COG3593	DNA synthesis involved in DNA repair
A6J62_RS03180	COG0583	DNA-binding transcription factor activity
A6J62_RS03185	COG2116	formate transmembrane transporter activity
A6J62_RS03195	COG3038	cytochrome b561
A6J62_RS03205	COG2200	EAL domain
A6J62_RS03215	COG0586	Pfam SNARE associated Golgi protein
A6J62_RS03220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J62_RS03225	COG0745	RESPONSE REGULATOR receiver
A6J62_RS03230	COG2205	protein histidine kinase activity
A6J62_RS03235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6J62_RS03235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J62_RS03235	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6J62_RS03235	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6J62_RS03250	COG0523	cobalamin synthesis protein
A6J62_RS03265	COG0156	8-amino-7-oxononanoate synthase activity
A6J62_RS03275	COG0784	Response regulator, receiver
A6J62_RS03275	COG2205	protein histidine kinase activity
A6J62_RS03280	COG0419	ATPase involved in DNA repair
A6J62_RS03285	COG0420	3'-5' exonuclease activity
A6J62_RS03290	COG1609	Transcriptional regulator
A6J62_RS03295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J62_RS03295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J62_RS03300	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J62_RS03305	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6J62_RS03305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J62_RS03305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J62_RS03310	COG4067	protein conserved in archaea
A6J62_RS03310	COG0189	ligase activity
A6J62_RS03320	COG0602	queuosine metabolic process
A6J62_RS03325	COG1328	CTP reductase activity
A6J62_RS03345	COG0346	lactoylglutathione lyase activity
A6J62_RS03490	COG0346	lactoylglutathione lyase activity
A6J62_RS03505	COG0110	maltose O-acetyltransferase activity
A6J62_RS03510	COG3039	Transposase
A6J62_RS03525	COG2944	sequence-specific DNA binding
A6J62_RS03530	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A6J62_RS03635	COG4977	sequence-specific DNA binding
A6J62_RS03640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A6J62_RS03695	COG3040	lipid binding
A6J62_RS03715	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J62_RS03810	COG0384	phenazine biosynthesis protein PhzF
A6J62_RS03835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J62_RS03895	COG3040	lipid binding
A6J62_RS03930	COG0346	lactoylglutathione lyase activity
A6J62_RS03960	COG0384	phenazine biosynthesis protein PhzF
A6J62_RS03980	COG3093	addiction module antidote protein HigA
A6J62_RS03985	COG3549	Plasmid maintenance system killer
A6J62_RS04185	COG1280	lysine exporter protein (LysE YggA)
A6J62_RS04195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A6J62_RS04215	COG3040	lipid binding
A6J62_RS04235	COG0346	lactoylglutathione lyase activity
A6J62_RS04285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A6J62_RS04295	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J62_RS04390	COG3041	Addiction module toxin RelE StbE family
A6J62_RS04415	COG3040	lipid binding
A6J62_RS04420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J62_RS04440	COG0494	nUDIX hydrolase
A6J62_RS04465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6J62_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
A6J62_RS04580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6J62_RS04585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J62_RS04620	COG3039	Transposase
A6J62_RS04630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J62_RS04640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J62_RS04645	COG0509	glycine decarboxylation via glycine cleavage system
A6J62_RS04650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J62_RS04650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J62_RS04680	COG1686	Belongs to the peptidase S11 family
A6J62_RS04695	COG2814	Major facilitator Superfamily
A6J62_RS04710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J62_RS04735	COG5002	protein histidine kinase activity
A6J62_RS04740	COG0745	RESPONSE REGULATOR receiver
A6J62_RS04765	COG0366	Alpha amylase catalytic
A6J62_RS04770	COG3038	cytochrome b561
A6J62_RS04800	COG0561	phosphatase activity
A6J62_RS04805	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A6J62_RS04810	COG3623	hexulose-6-phosphate isomerase
A6J62_RS04820	COG0745	RESPONSE REGULATOR receiver
A6J62_RS04840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J62_RS04855	COG2207	Transcriptional regulator
A6J62_RS04860	COG4604	ABC transporter, ATP-binding protein
A6J62_RS04865	COG4605	iron ion homeostasis
A6J62_RS04870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J62_RS04895	COG5380	lipid catabolic process
A6J62_RS04900	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6J62_RS04905	COG0840	transmembrane signaling receptor activity
A6J62_RS04915	COG3240	lipase activity
A6J62_RS04920	COG3706	GGDEF domain
A6J62_RS04930	COG2814	Major facilitator Superfamily
A6J62_RS04935	COG1757	Na H antiporter
A6J62_RS04945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J62_RS04945	COG4191	Histidine kinase
A6J62_RS04950	COG3437	response regulator, receiver
A6J62_RS04950	COG0784	Response regulator, receiver
A6J62_RS04960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J62_RS04965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J62_RS04970	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J62_RS04975	COG0513	Belongs to the DEAD box helicase family
A6J62_RS05015	COG0516	GMP reductase activity
A6J62_RS05040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J62_RS05045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J62_RS05045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6J62_RS05070	COG3036	rescue of stalled ribosome
A6J62_RS05075	COG1278	Cold shock
A6J62_RS05080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J62_RS05080	COG1017	nitric oxide dioxygenase activity
A6J62_RS05085	COG3604	Transcriptional regulator
A6J62_RS05095	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J62_RS05100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J62_RS05115	COG0840	transmembrane signaling receptor activity
A6J62_RS05120	COG0714	Associated with various cellular activities
A6J62_RS05140	COG2304	oxidoreductase activity
A6J62_RS05155	COG1278	Cold shock
A6J62_RS05160	COG5001	Diguanylate cyclase
A6J62_RS05160	COG5002	protein histidine kinase activity
A6J62_RS05170	COG3530	Putative quorum-sensing-regulated virulence factor
A6J62_RS05185	COG0814	amino acid
A6J62_RS05190	COG0589	response to stress
A6J62_RS05200	COG2111	Na H antiporter
A6J62_RS05200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J62_RS05205	COG1006	Multisubunit Na H antiporter MnhC subunit
A6J62_RS05210	COG0651	ATP synthesis coupled electron transport
A6J62_RS05215	COG1863	multisubunit Na H antiporter MnhE subunit
A6J62_RS05220	COG2212	antiporter activity
A6J62_RS05225	COG1320	monovalent cation:proton antiporter activity
A6J62_RS05235	COG0242	peptide deformylase activity
A6J62_RS05245	COG0579	oxidoreductase
A6J62_RS05285	COG2271	Major facilitator Superfamily
A6J62_RS05290	COG0584	glycerophosphoryl diester phosphodiesterase
A6J62_RS05300	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6J62_RS05305	COG3201	nicotinamide mononucleotide transporter
A6J62_RS05315	COG1609	Transcriptional regulator
A6J62_RS05320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J62_RS05325	COG1879	ABC-type sugar transport system periplasmic component
A6J62_RS05330	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J62_RS05335	COG1129	ABC transporter
A6J62_RS05340	COG1869	D-ribose catabolic process
A6J62_RS05355	COG3501	Rhs element vgr protein
A6J62_RS05355	COG3409	Peptidoglycan-binding domain 1 protein
A6J62_RS05385	COG3829	transcription factor binding
A6J62_RS05450	COG0564	pseudouridine synthase activity
A6J62_RS05465	COG0070	glutamate synthase
A6J62_RS05465	COG0069	glutamate synthase activity
A6J62_RS05465	COG0067	glutamate synthase
A6J62_RS05470	COG1242	4 iron, 4 sulfur cluster binding
A6J62_RS05475	COG5001	Diguanylate cyclase
A6J62_RS05475	COG3706	GGDEF domain
A6J62_RS05475	COG2203	Gaf domain
A6J62_RS05475	COG4251	negative regulation of phosphorylation
A6J62_RS05480	COG0784	Response regulator, receiver
A6J62_RS05480	COG2198	Histidine kinase
A6J62_RS05480	COG5002	protein histidine kinase activity
A6J62_RS05485	COG0745	RESPONSE REGULATOR receiver
A6J62_RS05495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6J62_RS05520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6J62_RS05525	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A6J62_RS05530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6J62_RS05535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J62_RS05550	COG1115	amino acid carrier protein
A6J62_RS05555	COG3022	response to hydroperoxide
A6J62_RS05560	COG0084	hydrolase, TatD family'
A6J62_RS05565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J62_RS05575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6J62_RS05580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6J62_RS05585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6J62_RS05590	COG0813	purine-nucleoside phosphorylase activity
A6J62_RS05600	COG0560	Phosphoserine phosphatase
A6J62_RS05615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6J62_RS05620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J62_RS05625	COG1022	Amp-dependent synthetase and ligase
A6J62_RS05645	COG1609	Transcriptional regulator
A6J62_RS05650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J62_RS05665	COG0569	domain protein
A6J62_RS05665	COG0189	ligase activity
A6J62_RS05670	COG0456	acetyltransferase
A6J62_RS05680	COG2171	N-acyltransferase activity
A6J62_RS05685	COG3141	response to X-ray
A6J62_RS05700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6J62_RS05710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J62_RS05720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J62_RS05720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6J62_RS05735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J62_RS05740	COG2166	iron-sulfur cluster assembly
A6J62_RS05745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J62_RS05750	COG0693	protein deglycase activity
A6J62_RS05755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6J62_RS05760	COG3248	Nucleoside-binding outer membrane protein
A6J62_RS05770	COG1595	DNA-templated transcription, initiation
A6J62_RS05780	COG2211	Major facilitator Superfamily
A6J62_RS05790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J62_RS05800	COG2813	Specifically methylates the guanine in position
A6J62_RS05805	COG0271	Belongs to the BolA IbaG family
A6J62_RS05810	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J62_RS05815	COG1805	sodium ion transport
A6J62_RS05820	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J62_RS05825	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J62_RS05830	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J62_RS05835	COG2871	sodium ion transport
A6J62_RS05840	COG1477	protein flavinylation
A6J62_RS05860	COG3706	GGDEF domain
A6J62_RS05865	COG0733	neurotransmitter:sodium symporter activity
A6J62_RS05875	COG0189	ligase activity
A6J62_RS05880	COG0189	ligase activity
A6J62_RS05880	COG4067	protein conserved in archaea
A6J62_RS05885	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J62_RS05890	COG2252	PERMEase
A6J62_RS05895	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6J62_RS05910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J62_RS05915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J62_RS05920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J62_RS05925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J62_RS05925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J62_RS05940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6J62_RS05945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J62_RS05950	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6J62_RS05955	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6J62_RS05970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6J62_RS05975	COG0024	Methionine aminopeptidase
A6J62_RS05980	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J62_RS05985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J62_RS05990	COG0528	UMP kinase activity
A6J62_RS05995	COG0233	cytoplasmic translational termination
A6J62_RS06000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J62_RS06005	COG0575	Belongs to the CDS family
A6J62_RS06010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6J62_RS06015	COG0750	zinc metalloprotease
A6J62_RS06025	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6J62_RS06035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J62_RS06040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J62_RS06045	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J62_RS06050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J62_RS06055	COG0587	DNA-directed DNA polymerase activity
A6J62_RS06060	COG0825	malonyl-CoA metabolic process
A6J62_RS06065	COG0037	tRNA processing
A6J62_RS06075	COG3479	Phenolic acid decarboxylase
A6J62_RS06080	COG0347	Belongs to the P(II) protein family
A6J62_RS06085	COG3021	interspecies interaction between organisms
A6J62_RS06090	COG0741	lytic transglycosylase activity
A6J62_RS06090	COG1388	LysM domain
A6J62_RS06095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J62_RS06100	COG2226	methyltransferase
A6J62_RS06105	COG0328	RNA-DNA hybrid ribonuclease activity
A6J62_RS06120	COG1960	acyl-CoA dehydrogenase activity
A6J62_RS06125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J62_RS06130	COG0121	glutamine amidotransferase
A6J62_RS06135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J62_RS06140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J62_RS06145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J62_RS06155	COG1187	pseudouridine synthase activity
A6J62_RS06160	COG2840	Smr protein MutS2
A6J62_RS06175	COG3735	TraB family
A6J62_RS06190	COG2217	Heavy metal translocating P-type atpase
A6J62_RS06190	COG2608	mercury ion transmembrane transporter activity
A6J62_RS06195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J62_RS06215	COG2375	cellular response to nickel ion
A6J62_RS06255	COG0784	Response regulator, receiver
A6J62_RS06255	COG0835	chemotaxis
A6J62_RS06260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J62_RS06265	COG1815	bacterial-type flagellum-dependent cell motility
A6J62_RS06280	COG1749	Flagellar hook protein flgE
A6J62_RS06285	COG4787	bacterial-type flagellum-dependent cell motility
A6J62_RS06295	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6J62_RS06300	COG1706	bacterial-type flagellum-dependent cell motility
A6J62_RS06305	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J62_RS06305	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6J62_RS06320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J62_RS06325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J62_RS06410	COG0012	GTP binding
A6J62_RS06415	COG0193	aminoacyl-tRNA hydrolase activity
A6J62_RS06420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J62_RS06430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6J62_RS06435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6J62_RS06440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J62_RS06445	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J62_RS06455	COG2912	Transglutaminase-like superfamily
A6J62_RS06460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6J62_RS06465	COG0737	Belongs to the 5'-nucleotidase family
A6J62_RS06470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J62_RS06475	COG2233	PERMEase
A6J62_RS06495	COG1393	Belongs to the ArsC family
A6J62_RS06500	COG4783	chaperone-mediated protein folding
A6J62_RS06520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J62_RS06535	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6J62_RS06545	COG1876	peptidase activity
A6J62_RS06555	COG1393	Belongs to the ArsC family
A6J62_RS06575	COG2837	iron assimilation
A6J62_RS06580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J62_RS06585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J62_RS06590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J62_RS06595	COG1334	flagellar protein FlaG
A6J62_RS06600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6J62_RS06610	COG1516	flagellar protein fliS
A6J62_RS06630	COG1677	Flagellar hook-basal body complex protein FliE
A6J62_RS06640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J62_RS06645	COG1317	bacterial-type flagellum organization
A6J62_RS06670	COG1580	Controls the rotational direction of flagella during chemotaxis
A6J62_RS06695	COG1987	bacterial-type flagellum assembly
A6J62_RS06700	COG1684	flagellar biosynthetic protein fliR
A6J62_RS06710	COG2840	Smr protein MutS2
A6J62_RS06715	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J62_RS06725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J62_RS06730	COG2860	membrane
A6J62_RS06735	COG3101	peptidyl-lysine hydroxylation
A6J62_RS06745	COG0431	NADPH-dependent FMN reductase
A6J62_RS06755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J62_RS06760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J62_RS06765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J62_RS06770	COG0735	belongs to the Fur family
A6J62_RS06780	COG0583	DNA-binding transcription factor activity
A6J62_RS06790	COG1346	cytolysis
A6J62_RS06805	COG0596	Alpha beta hydrolase
A6J62_RS06810	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6J62_RS06815	COG0033	Phosphoglucomutase
A6J62_RS06825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J62_RS06830	COG0372	Belongs to the citrate synthase family
A6J62_RS06835	COG2009	succinate dehydrogenase
A6J62_RS06840	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6J62_RS06845	COG1053	succinate dehydrogenase
A6J62_RS06855	COG0567	Dehydrogenase, E1 component
A6J62_RS06860	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J62_RS06865	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J62_RS06875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J62_RS06880	COG1121	(ABC) transporter
A6J62_RS06885	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6J62_RS06890	COG4977	sequence-specific DNA binding
A6J62_RS06895	COG1918	ferrous iron import across plasma membrane
A6J62_RS06915	COG0018	arginyl-trna synthetase
A6J62_RS06930	COG2062	phosphohistidine phosphatase, SixA
A6J62_RS06960	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6J62_RS06965	COG0643	Histidine kinase
A6J62_RS06965	COG0784	Response regulator, receiver
A6J62_RS06965	COG2198	Histidine kinase
A6J62_RS06970	COG2201	protein-glutamate methylesterase activity
A6J62_RS06975	COG1192	Involved in chromosome partitioning
A6J62_RS06985	COG0835	chemotaxis
A6J62_RS06995	COG4133	protoheme IX ABC transporter activity
A6J62_RS07000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J62_RS07005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J62_RS07015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6J62_RS07020	COG1138	Cytochrome C-type biogenesis protein
A6J62_RS07025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J62_RS07030	COG3088	subunit of a heme lyase
A6J62_RS07030	COG4235	cytochrome complex assembly
A6J62_RS07040	COG2853	Lipoprotein
A6J62_RS07060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6J62_RS07070	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6J62_RS07085	COG3083	sulfuric ester hydrolase activity
A6J62_RS07090	COG3082	Protein of unknown function (DUF1414)
A6J62_RS07095	COG3081	Nucleoid-associated protein
A6J62_RS07105	COG1757	Na H antiporter
A6J62_RS07110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J62_RS07115	COG2095	MarC family integral membrane protein
A6J62_RS07120	COG1454	alcohol dehydrogenase
A6J62_RS07120	COG1012	belongs to the aldehyde dehydrogenase family
A6J62_RS07135	COG0659	secondary active sulfate transmembrane transporter activity
A6J62_RS07140	COG1530	ribonuclease E activity
A6J62_RS07155	COG0564	pseudouridine synthase activity
A6J62_RS07160	COG0424	maF-like protein
A6J62_RS07165	COG1399	metal-binding, possibly nucleic acid-binding protein
A6J62_RS07170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6J62_RS07175	COG0416	fatty acid biosynthetic process
A6J62_RS07180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J62_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
A6J62_RS07195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J62_RS07200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J62_RS07205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J62_RS07210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J62_RS07215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6J62_RS07225	COG0084	hydrolase, TatD family'
A6J62_RS07230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J62_RS07230	COG1263	PTS System
A6J62_RS07235	COG0733	neurotransmitter:sodium symporter activity
A6J62_RS07245	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J62_RS07255	COG1940	carbohydrate kinase activity
A6J62_RS07260	COG0835	chemotaxis
A6J62_RS07260	COG0784	Response regulator, receiver
A6J62_RS07275	COG2226	methyltransferase
A6J62_RS07295	COG0676	glucose-6-phosphate 1-epimerase activity
A6J62_RS07300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J62_RS07305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J62_RS07315	COG3139	Protein of unknown function (DUF1315)
A6J62_RS07320	COG0252	asparaginase activity
A6J62_RS07325	COG0616	signal peptide processing
A6J62_RS07330	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J62_RS07330	COG1902	pentaerythritol trinitrate reductase activity
A6J62_RS07335	COG0788	formyltetrahydrofolate deformylase activity
A6J62_RS07345	COG1199	ATP-dependent helicase activity
A6J62_RS07350	COG1214	PFAM Peptidase M22, glycoprotease
A6J62_RS07365	COG0596	Alpha beta hydrolase
A6J62_RS07370	COG0318	PFAM AMP-dependent synthetase and ligase
A6J62_RS07375	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6J62_RS07395	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6J62_RS07400	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6J62_RS07405	COG0436	Aminotransferase
A6J62_RS07410	COG1169	isochorismate synthase
A6J62_RS07415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6J62_RS07420	COG0596	Alpha beta hydrolase
A6J62_RS07440	COG3135	benzoate transporter
A6J62_RS07445	COG1396	sequence-specific DNA binding
A6J62_RS07450	COG0840	transmembrane signaling receptor activity
A6J62_RS07455	COG0477	Major facilitator Superfamily
A6J62_RS07475	COG3015	lipoprotein NlpE involved in copper resistance
A6J62_RS07480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6J62_RS07485	COG2894	cell division
A6J62_RS07490	COG0850	regulation of cytokinetic process
A6J62_RS07495	COG3100	YcgL domain-containing protein
A6J62_RS07500	COG2951	lytic endotransglycosylase activity
A6J62_RS07510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J62_RS07515	COG3325	Belongs to the glycosyl hydrolase 18 family
A6J62_RS07515	COG3469	chitinase activity
A6J62_RS07520	COG3005	denitrification pathway
A6J62_RS07525	COG0243	molybdopterin cofactor binding
A6J62_RS07545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J62_RS07555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J62_RS07595	COG4589	Belongs to the CDS family
A6J62_RS07605	COG5001	Diguanylate cyclase
A6J62_RS07605	COG3300	MHYT domain
A6J62_RS07620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6J62_RS07625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J62_RS07630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6J62_RS07635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6J62_RS07645	COG4191	Histidine kinase
A6J62_RS07655	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J62_RS07665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J62_RS07670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J62_RS07675	COG0776	regulation of translation
A6J62_RS07680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J62_RS07685	COG1555	photosystem II stabilization
A6J62_RS07690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6J62_RS07695	COG0539	negative regulation of cytoplasmic translation
A6J62_RS07700	COG0776	regulation of translation
A6J62_RS07705	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6J62_RS07710	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6J62_RS07730	COG0583	DNA-binding transcription factor activity
A6J62_RS07740	COG0686	Belongs to the AlaDH PNT family
A6J62_RS07750	COG1674	ftsk spoiiie
A6J62_RS07755	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6J62_RS07760	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J62_RS07765	COG2186	Transcriptional regulator
A6J62_RS07780	COG0537	adenosine 5'-monophosphoramidase activity
A6J62_RS07805	COG3150	esterase
A6J62_RS07810	COG1252	NADH dehydrogenase
A6J62_RS07830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J62_RS07840	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6J62_RS07845	COG1136	(ABC) transporter
A6J62_RS07850	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6J62_RS07860	COG2333	competence protein COMEC
A6J62_RS07860	COG0658	competence protein
A6J62_RS07865	COG1132	(ABC) transporter
A6J62_RS07870	COG1663	tetraacyldisaccharide 4'-kinase activity
A6J62_RS07875	COG2835	tetraacyldisaccharide 4'-kinase activity
A6J62_RS07880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6J62_RS07885	COG2719	SpoVR family
A6J62_RS07890	COG2718	Belongs to the UPF0229 family
A6J62_RS07895	COG2766	serine protein kinase
A6J62_RS07900	COG3013	Belongs to the UPF0304 family
A6J62_RS07910	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J62_RS07915	COG0840	transmembrane signaling receptor activity
A6J62_RS07925	COG1882	Formate acetyltransferase
A6J62_RS07950	COG4160	amino acid transport
A6J62_RS07955	COG0708	Exodeoxyribonuclease III
A6J62_RS07960	COG0840	transmembrane signaling receptor activity
A6J62_RS07970	COG3923	Primosomal replication protein n
A6J62_RS07975	COG0730	response to heat
A6J62_RS07985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6J62_RS07990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6J62_RS07995	COG3012	SEC-C Motif Domain Protein
A6J62_RS08000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6J62_RS08005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J62_RS08010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J62_RS08015	COG0215	cysteine-tRNA ligase activity
A6J62_RS08020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6J62_RS08025	COG0632	four-way junction helicase activity
A6J62_RS08035	COG1271	oxidase subunit
A6J62_RS08040	COG1294	oxidase, subunit
A6J62_RS08045	COG4890	Cyd operon protein YbgT
A6J62_RS08050	COG3790	cyd operon protein YbgE
A6J62_RS08055	COG0824	Thioesterase
A6J62_RS08060	COG0811	peptide transport
A6J62_RS08075	COG0823	Involved in the tonB-independent uptake of proteins
A6J62_RS08080	COG2885	chlorophyll binding
A6J62_RS08090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6J62_RS08110	COG1482	cell wall glycoprotein biosynthetic process
A6J62_RS08115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J62_RS08115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J62_RS08115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J62_RS08120	COG2207	Transcriptional regulator
A6J62_RS08130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J62_RS08135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J62_RS08140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J62_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
A6J62_RS08155	COG3284	Transcriptional regulator
A6J62_RS08160	COG4628	conserved protein (DUF2132)
A6J62_RS08170	COG0415	Belongs to the DNA photolyase family
A6J62_RS08255	COG0488	(ABC) transporter
A6J62_RS08300	COG3941	tape measure
A6J62_RS08315	COG2003	Belongs to the UPF0758 family
A6J62_RS08325	COG4409	exo-alpha-(2->6)-sialidase activity
A6J62_RS08330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6J62_RS08335	COG1940	carbohydrate kinase activity
A6J62_RS08350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J62_RS08355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6J62_RS08360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6J62_RS08365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J62_RS08370	COG1737	Transcriptional regulator
A6J62_RS08375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A6J62_RS08380	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A6J62_RS08400	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A6J62_RS08420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6J62_RS08440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J62_RS08445	COG0582	viral genome integration into host DNA
A6J62_RS08450	COG0582	viral genome integration into host DNA
A6J62_RS08465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J62_RS08475	COG3008	intermembrane lipid transfer
A6J62_RS08475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J62_RS08480	COG2995	paraquat-inducible protein a
A6J62_RS08485	COG0668	transmembrane transport
A6J62_RS08510	COG1309	transcriptional regulator
A6J62_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
A6J62_RS08540	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J62_RS08550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J62_RS08580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J62_RS08585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J62_RS08590	COG0297	glycogen (starch) synthase activity
A6J62_RS08610	COG3070	regulator of competence-specific genes
A6J62_RS08615	COG1609	Transcriptional regulator
A6J62_RS08625	COG3381	protein complex oligomerization
A6J62_RS08630	COG0745	RESPONSE REGULATOR receiver
A6J62_RS08640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J62_RS08650	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6J62_RS08670	COG1032	radical SAM domain protein
A6J62_RS08675	COG5001	Diguanylate cyclase
A6J62_RS08680	COG0612	Peptidase, M16
A6J62_RS08695	COG0583	DNA-binding transcription factor activity
A6J62_RS08700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J62_RS08710	COG2350	Protein conserved in bacteria
A6J62_RS08715	COG1607	acyl-coa hydrolase
A6J62_RS08730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6J62_RS08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J62_RS08750	COG2116	formate transmembrane transporter activity
A6J62_RS08760	COG4459	periplasmic nitrate reductase
A6J62_RS08765	COG3005	denitrification pathway
A6J62_RS08770	COG0243	molybdopterin cofactor binding
A6J62_RS08795	COG1227	inorganic diphosphatase activity
A6J62_RS08810	COG4172	Belongs to the ABC transporter superfamily
A6J62_RS08825	COG4168	peptide transport system, permease
A6J62_RS08835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6J62_RS08840	COG1842	Phage shock protein A
A6J62_RS08855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J62_RS08870	COG2818	Glycosylase
A6J62_RS08875	COG0626	cystathionine gamma-synthase activity
A6J62_RS08890	COG0733	neurotransmitter:sodium symporter activity
A6J62_RS08895	COG0564	pseudouridine synthase activity
A6J62_RS08900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J62_RS08905	COG4136	ATPase activity
A6J62_RS08910	COG4135	transport system, permease component
A6J62_RS08915	COG4134	Bacterial extracellular solute-binding protein
A6J62_RS08925	COG3313	Fe-S protein
A6J62_RS08935	COG0842	Transport permease protein
A6J62_RS08940	COG1131	(ABC) transporter
A6J62_RS08945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J62_RS08950	COG0814	amino acid
A6J62_RS08960	COG2239	Acts as a magnesium transporter
A6J62_RS08965	COG2205	protein histidine kinase activity
A6J62_RS08965	COG0784	Response regulator, receiver
A6J62_RS08980	COG4934	collagen metabolic process
A6J62_RS09010	COG0840	transmembrane signaling receptor activity
A6J62_RS09025	COG3706	GGDEF domain
A6J62_RS09025	COG5001	Diguanylate cyclase
A6J62_RS09025	COG4251	negative regulation of phosphorylation
A6J62_RS09025	COG2203	Gaf domain
A6J62_RS09030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6J62_RS09050	COG1061	Type III restriction enzyme res subunit
A6J62_RS09055	COG1187	pseudouridine synthase activity
A6J62_RS09060	COG2814	Major facilitator Superfamily
A6J62_RS09070	COG0702	epimerase
A6J62_RS09075	COG0534	Mate efflux family protein
A6J62_RS09080	COG4181	ATPase activity
A6J62_RS09095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J62_RS09110	COG1748	Saccharopine dehydrogenase
A6J62_RS09125	COG1538	Outer membrane efflux protein
A6J62_RS09145	COG0583	DNA-binding transcription factor activity
A6J62_RS09155	COG1451	nucleotide metabolic process
A6J62_RS09160	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6J62_RS09170	COG3063	Type IV pilus biogenesis stability protein PilW
A6J62_RS09175	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6J62_RS09195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J62_RS09210	COG3290	protein histidine kinase activity
A6J62_RS09215	COG4565	transcriptional regulatory protein
A6J62_RS09225	COG0835	chemotaxis
A6J62_RS09225	COG0784	Response regulator, receiver
A6J62_RS09270	COG1085	galactose-1-phosphate uridylyltransferase
A6J62_RS09275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6J62_RS09280	COG2017	converts alpha-aldose to the beta-anomer
A6J62_RS09290	COG2199	diguanylate cyclase activity
A6J62_RS09290	COG2200	EAL domain
A6J62_RS09305	COG3527	Alpha-acetolactate decarboxylase
A6J62_RS09320	COG0753	catalase activity
A6J62_RS09340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J62_RS09350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6J62_RS09400	COG1294	oxidase, subunit
A6J62_RS09405	COG1136	(ABC) transporter
A6J62_RS09405	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6J62_RS09410	COG1136	(ABC) transporter
A6J62_RS09410	COG0577	efflux transmembrane transporter activity
A6J62_RS09415	COG0577	efflux transmembrane transporter activity
A6J62_RS09415	COG1136	(ABC) transporter
A6J62_RS09435	COG0583	DNA-binding transcription factor activity
A6J62_RS09445	COG2723	6-phospho-beta-galactosidase activity
A6J62_RS09450	COG1609	Transcriptional regulator
A6J62_RS09455	COG0251	oxidation-reduction process
A6J62_RS09460	COG2731	YhcH YjgK YiaL family protein
A6J62_RS09465	COG0584	glycerophosphoryl diester phosphodiesterase
A6J62_RS09470	COG1349	DNA-binding transcription factor activity
A6J62_RS09475	COG3842	ATPase activity
A6J62_RS09480	COG0395	ABC-type sugar transport system, permease component
A6J62_RS09485	COG1175	transmembrane transport
A6J62_RS09505	COG0811	peptide transport
A6J62_RS09510	COG0848	biopolymer transport protein
A6J62_RS09515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6J62_RS09530	COG1793	dna ligase
A6J62_RS09540	COG0534	Mate efflux family protein
A6J62_RS09550	COG3001	Fructosamine kinase
A6J62_RS09560	COG0791	NLP P60 protein
A6J62_RS09565	COG0840	transmembrane signaling receptor activity
A6J62_RS09575	COG3148	PFAM DTW domain containing protein
A6J62_RS09580	COG1940	carbohydrate kinase activity
A6J62_RS09615	COG0746	molybdenum cofactor guanylyltransferase activity
A6J62_RS09620	COG3842	ATPase activity
A6J62_RS09625	COG4662	Binding-protein-dependent transport system inner membrane component
A6J62_RS09635	COG2204	response regulator
A6J62_RS09640	COG3852	Histidine kinase
A6J62_RS09645	COG0488	(ABC) transporter
A6J62_RS09650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J62_RS09680	COG0243	molybdopterin cofactor binding
A6J62_RS09680	COG3383	formate dehydrogenase (NAD+) activity
A6J62_RS09685	COG0437	4 iron, 4 sulfur cluster binding
A6J62_RS09700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6J62_RS09705	COG1666	GTP binding
A6J62_RS09710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J62_RS09735	COG3008	intermembrane lipid transfer
A6J62_RS09740	COG2995	paraquat-inducible protein a
A6J62_RS09745	COG1132	(ABC) transporter
A6J62_RS09750	COG1956	GAF domain-containing protein
A6J62_RS09755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6J62_RS09770	COG0308	aminopeptidase N
A6J62_RS09785	COG0167	dihydroorotate dehydrogenase activity
A6J62_RS09795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J62_RS09795	COG0116	Belongs to the methyltransferase superfamily
A6J62_RS09805	COG0488	(ABC) transporter
A6J62_RS09820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J62_RS09825	COG1067	ATP-dependent peptidase activity
A6J62_RS09830	COG3120	sequence-specific DNA binding
A6J62_RS09930	COG1476	TRANSCRIPTIONal
A6J62_RS09960	COG4128	Pfam Zonular occludens toxin
A6J62_RS09980	COG1476	TRANSCRIPTIONal
A6J62_RS10005	COG1476	TRANSCRIPTIONal
A6J62_RS10025	COG3064	Membrane
A6J62_RS10025	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A6J62_RS10025	COG1073	alpha beta
A6J62_RS10035	COG2994	toxin metabolic process
A6J62_RS10060	COG2205	protein histidine kinase activity
A6J62_RS10060	COG0784	Response regulator, receiver
A6J62_RS10075	COG3278	Belongs to the heme-copper respiratory oxidase family
A6J62_RS10090	COG2010	Cytochrome c
A6J62_RS10100	COG2217	Heavy metal translocating P-type atpase
A6J62_RS10115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J62_RS10120	COG0589	response to stress
A6J62_RS10145	COG3842	ATPase activity
A6J62_RS10155	COG1177	transmembrane transport
A6J62_RS10165	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6J62_RS10180	COG1115	amino acid carrier protein
A6J62_RS10185	COG1280	lysine exporter protein (LysE YggA)
A6J62_RS10200	COG3675	Pfam Lipase (class 3)
A6J62_RS10210	COG3501	Rhs element vgr protein
A6J62_RS10220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6J62_RS10230	COG2814	Major facilitator Superfamily
A6J62_RS10235	COG1566	PFAM secretion protein HlyD family protein
A6J62_RS10240	COG1538	Outer membrane efflux protein
A6J62_RS10250	COG0513	Belongs to the DEAD box helicase family
A6J62_RS10260	COG0840	transmembrane signaling receptor activity
A6J62_RS10265	COG0840	transmembrane signaling receptor activity
A6J62_RS10265	COG3290	protein histidine kinase activity
A6J62_RS10270	COG0835	chemotaxis
A6J62_RS10275	COG2201	protein-glutamate methylesterase activity
A6J62_RS10285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J62_RS10290	COG0643	Histidine kinase
A6J62_RS10290	COG0784	Response regulator, receiver
A6J62_RS10290	COG2198	Histidine kinase
A6J62_RS10295	COG2198	Histidine kinase
A6J62_RS10295	COG0643	Histidine kinase
A6J62_RS10305	COG0745	RESPONSE REGULATOR receiver
A6J62_RS10320	COG0415	Belongs to the DNA photolyase family
A6J62_RS10325	COG0477	Major facilitator Superfamily
A6J62_RS10330	COG0583	DNA-binding transcription factor activity
A6J62_RS10340	COG0095	Lipoate-protein ligase
A6J62_RS10345	COG0443	Heat shock 70 kDa protein
A6J62_RS10355	COG1643	Atp-dependent helicase
A6J62_RS10395	COG0443	Heat shock 70 kDa protein
A6J62_RS10400	COG0443	Heat shock 70 kDa protein
A6J62_RS10405	COG3706	GGDEF domain
A6J62_RS10435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6J62_RS10440	COG0602	queuosine metabolic process
A6J62_RS10445	COG0561	phosphatase activity
A6J62_RS10455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J62_RS10460	COG4597	amino acid ABC transporter
A6J62_RS10465	COG0765	amino acid transport
A6J62_RS10470	COG1126	abc transporter atp-binding protein
A6J62_RS10475	COG0670	Belongs to the BI1 family
A6J62_RS10480	COG2920	part of a sulfur-relay system
A6J62_RS10485	COG1254	Belongs to the acylphosphatase family
A6J62_RS10490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J62_RS10515	COG3437	response regulator, receiver
A6J62_RS10520	COG0625	glutathione transferase activity
A6J62_RS10530	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6J62_RS10540	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J62_RS10570	COG0372	Belongs to the citrate synthase family
A6J62_RS10575	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6J62_RS10615	COG1129	ABC transporter
A6J62_RS10645	COG0745	RESPONSE REGULATOR receiver
A6J62_RS10650	COG2205	protein histidine kinase activity
A6J62_RS10655	COG3713	MltA-interacting MipA family protein
A6J62_RS10660	COG2990	Protein conserved in bacteria
A6J62_RS10670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J62_RS10670	COG4191	Histidine kinase
A6J62_RS10675	COG0471	metal ion transport
A6J62_RS10685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J62_RS10700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J62_RS10710	COG3768	UPF0283 membrane protein
A6J62_RS10715	COG3106	COG3106 Predicted ATPase
A6J62_RS10730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J62_RS10735	COG0494	nUDIX hydrolase
A6J62_RS10740	COG0814	amino acid
A6J62_RS10745	COG1760	l-serine dehydratase
A6J62_RS10750	COG0720	synthase
A6J62_RS10760	COG0017	Asparaginyl-tRNA synthetase
A6J62_RS10765	COG0351	phosphomethylpyrimidine kinase
A6J62_RS10770	COG3437	response regulator, receiver
A6J62_RS10770	COG2770	Histidine kinase
A6J62_RS10780	COG1448	Aminotransferase
A6J62_RS10795	COG0840	transmembrane signaling receptor activity
A6J62_RS10800	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6J62_RS10805	COG2943	transferase activity, transferring hexosyl groups
A6J62_RS10810	COG1609	Transcriptional regulator
A6J62_RS10820	COG1486	melibiose metabolic process
A6J62_RS10825	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J62_RS10835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J62_RS10840	COG0726	polysaccharide deacetylase
A6J62_RS10845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J62_RS10850	COG1846	Transcriptional regulator
A6J62_RS10875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6J62_RS10890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J62_RS10895	COG3108	Peptidase M15
A6J62_RS10900	COG2989	Protein conserved in bacteria
A6J62_RS10925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J62_RS10935	COG2814	Major facilitator Superfamily
A6J62_RS10945	COG1054	Belongs to the UPF0176 family
A6J62_RS10955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J62_RS10960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J62_RS10965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J62_RS11040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6J62_RS11045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6J62_RS11055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J62_RS11060	COG1823	symporter activity
A6J62_RS11065	COG2925	Exonuclease
A6J62_RS11070	COG1380	Effector of murein hydrolase LrgA
A6J62_RS11075	COG1346	cytolysis
A6J62_RS11115	COG0776	regulation of translation
A6J62_RS11120	COG0072	phenylalanine-tRNA ligase activity
A6J62_RS11120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J62_RS11125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6J62_RS11165	COG0322	excinuclease ABC activity
A6J62_RS11170	COG2197	response regulator
A6J62_RS11175	COG0417	DNA replication proofreading
A6J62_RS11180	COG5001	Diguanylate cyclase
A6J62_RS11190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J62_RS11195	COG3099	Belongs to the UPF0263 family
A6J62_RS11210	COG1228	amidohydrolase
A6J62_RS11215	COG0010	Belongs to the arginase family
A6J62_RS11220	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6J62_RS11225	COG2986	histidine ammonia-lyase
A6J62_RS11260	COG2885	chlorophyll binding
A6J62_RS11280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J62_RS11290	COG0281	malic enzyme
A6J62_RS11300	COG2949	membrane
A6J62_RS11310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J62_RS11320	COG0492	ferredoxin-NADP+ reductase activity
A6J62_RS11325	COG4988	ABC transporter
A6J62_RS11330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6J62_RS11335	COG1187	pseudouridine synthase activity
A6J62_RS11340	COG0009	L-threonylcarbamoyladenylate synthase
A6J62_RS11345	COG0613	PHP domain protein
A6J62_RS11355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J62_RS11360	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J62_RS11365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J62_RS11370	COG0134	indole-3-glycerol-phosphate synthase activity
A6J62_RS11370	COG0135	phosphoribosylanthranilate isomerase activity
A6J62_RS11375	COG0133	tryptophan synthase activity
A6J62_RS11380	COG0159	tryptophan synthase activity
A6J62_RS11390	COG1435	thymidine kinase activity
A6J62_RS11395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J62_RS11400	COG1801	Protein of unknown function DUF72
A6J62_RS11405	COG4106	trans-aconitate 2-methyltransferase activity
A6J62_RS11410	COG0500	methyltransferase
A6J62_RS11415	COG0189	ligase activity
A6J62_RS11415	COG4067	protein conserved in archaea
A6J62_RS11440	COG3852	Histidine kinase
A6J62_RS11455	COG3070	regulator of competence-specific genes
A6J62_RS11465	COG2431	L-lysine efflux transmembrane transporter activity
A6J62_RS11475	COG0076	glutamate decarboxylase activity
A6J62_RS11480	COG1737	Transcriptional regulator
A6J62_RS11485	COG1012	belongs to the aldehyde dehydrogenase family
A6J62_RS11485	COG1454	alcohol dehydrogenase
A6J62_RS11490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J62_RS11495	COG3273	potassium ion transport
A6J62_RS11495	COG2985	domain, Protein
A6J62_RS11500	COG0542	response to heat
A6J62_RS11505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6J62_RS11510	COG1278	Cold shock
A6J62_RS11520	COG1187	pseudouridine synthase activity
A6J62_RS11525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6J62_RS11525	COG0140	phosphoribosyl-ATP diphosphatase activity
A6J62_RS11530	COG0107	imidazoleglycerol-phosphate synthase activity
A6J62_RS11535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6J62_RS11540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6J62_RS11545	COG0131	Imidazoleglycerol-phosphate dehydratase
A6J62_RS11545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J62_RS11550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J62_RS11555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J62_RS11560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6J62_RS11565	COG1757	Na H antiporter
A6J62_RS11570	COG2916	Histone family protein nucleoid-structuring protein H-NS
A6J62_RS11575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J62_RS11580	COG0482	sulfurtransferase activity
A6J62_RS11585	COG2915	High frequency lysogenization protein hflD homolog
A6J62_RS11590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J62_RS11600	COG2268	Band 7 protein
A6J62_RS11610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J62_RS11625	COG0300	oxidoreductase activity
A6J62_RS11635	COG0501	Belongs to the peptidase M48B family
A6J62_RS11645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6J62_RS11650	COG2226	methyltransferase
A6J62_RS11655	COG0156	8-amino-7-oxononanoate synthase activity
A6J62_RS11660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J62_RS11665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J62_RS11670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J62_RS11675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J62_RS11690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J62_RS11695	COG2199	diguanylate cyclase activity
A6J62_RS11695	COG2203	Gaf domain
A6J62_RS11705	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6J62_RS11715	COG4628	conserved protein (DUF2132)
A6J62_RS11720	COG3092	negative regulation of chromosome organization
A6J62_RS11725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J62_RS11730	COG0857	belongs to the CobB CobQ family
A6J62_RS11730	COG0280	phosphate acetyltransferase
A6J62_RS11735	COG0435	Glutathione S-transferase
A6J62_RS11740	COG4608	Belongs to the ABC transporter superfamily
A6J62_RS11745	COG0444	Belongs to the ABC transporter superfamily
A6J62_RS11750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J62_RS11755	COG0601	transmembrane transport
A6J62_RS11775	COG2204	response regulator
A6J62_RS11780	COG5001	Diguanylate cyclase
A6J62_RS11780	COG3300	MHYT domain
A6J62_RS11785	COG4191	Histidine kinase
A6J62_RS11790	COG5002	protein histidine kinase activity
A6J62_RS11800	COG2201	protein-glutamate methylesterase activity
A6J62_RS11815	COG0009	L-threonylcarbamoyladenylate synthase
A6J62_RS11835	COG1881	PFAM PEBP family protein
A6J62_RS11860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J62_RS11865	COG0640	Transcriptional regulator
A6J62_RS11875	COG3706	GGDEF domain
A6J62_RS11895	COG1946	Acyl-CoA thioesterase
A6J62_RS11900	COG1522	sequence-specific DNA binding
A6J62_RS11910	COG0616	signal peptide processing
A6J62_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
A6J62_RS11920	COG2983	Belongs to the UPF0260 family
A6J62_RS11930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J62_RS11935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J62_RS11945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J62_RS11950	COG2832	Protein of unknown function (DUF454)
A6J62_RS11960	COG0745	RESPONSE REGULATOR receiver
A6J62_RS11965	COG0583	DNA-binding transcription factor activity
A6J62_RS11970	COG0778	Nitroreductase
A6J62_RS11975	COG1024	Enoyl-CoA hydratase
A6J62_RS11975	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J62_RS11980	COG0183	Belongs to the thiolase family
A6J62_RS12000	COG2067	long-chain fatty acid transport protein
A6J62_RS12010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J62_RS12015	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A6J62_RS12020	COG2982	Protein involved in outer membrane biogenesis
A6J62_RS12025	COG0572	uridine kinase
A6J62_RS12035	COG0489	protein tyrosine kinase activity
A6J62_RS12040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J62_RS12040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J62_RS12050	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6J62_RS12065	COG0517	IMP dehydrogenase activity
A6J62_RS12065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J62_RS12065	COG0617	tRNA 3'-terminal CCA addition
A6J62_RS12070	COG2199	diguanylate cyclase activity
A6J62_RS12075	COG0314	molybdopterin synthase activity
A6J62_RS12080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6J62_RS12085	COG0315	cyclic pyranopterin monophosphate synthase activity
A6J62_RS12090	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6J62_RS12095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6J62_RS12100	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6J62_RS12105	COG2198	Histidine kinase
A6J62_RS12110	COG2204	response regulator
A6J62_RS12120	COG0556	nucleotide-excision repair
A6J62_RS12130	COG4657	Part of a membrane complex involved in electron transport
A6J62_RS12135	COG2878	Part of a membrane complex involved in electron transport
A6J62_RS12140	COG4656	Part of a membrane complex involved in electron transport
A6J62_RS12160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J62_RS12165	COG0346	lactoylglutathione lyase activity
A6J62_RS12180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J62_RS12185	COG2056	Na+-H+ antiporter family
A6J62_RS12190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J62_RS12195	COG1286	toxin biosynthetic process
A6J62_RS12200	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6J62_RS12205	COG0285	dihydrofolate synthase activity
A6J62_RS12210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J62_RS12215	COG0101	tRNA pseudouridine synthase activity
A6J62_RS12230	COG1263	PTS System
A6J62_RS12230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J62_RS12230	COG2190	(PTS) system
A6J62_RS12235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6J62_RS12240	COG1846	Transcriptional regulator
A6J62_RS12240	COG1940	carbohydrate kinase activity
A6J62_RS12245	COG4651	solute:proton antiporter activity
A6J62_RS12245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J62_RS12250	COG0367	asparagine synthase
A6J62_RS12265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6J62_RS12270	COG0563	adenylate kinase activity
A6J62_RS12275	COG0326	Molecular chaperone. Has ATPase activity
A6J62_RS12280	COG3710	Transcriptional regulator
A6J62_RS12295	COG0622	Phosphoesterase
A6J62_RS12300	COG1090	epimerase
A6J62_RS12305	COG0300	oxidoreductase activity
A6J62_RS12310	COG3118	belongs to the thioredoxin family
A6J62_RS12320	COG0330	HflC and HflK could
A6J62_RS12325	COG1585	Membrane protein implicated in regulation of membrane protease activity
A6J62_RS12330	COG0789	Transcriptional regulator
A6J62_RS12345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J62_RS12350	COG3115	cell septum assembly
A6J62_RS12355	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A6J62_RS12360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6J62_RS12370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J62_RS12380	COG2190	(PTS) system
A6J62_RS12385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J62_RS12390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J62_RS12395	COG1702	phosphate starvation-inducible protein PhoH
A6J62_RS12405	COG4535	Mg2 and Co2 transporter CorC
A6J62_RS12410	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6J62_RS12415	COG2888	peptidyl-tyrosine sulfation
A6J62_RS12420	COG0495	leucyl-tRNA aminoacylation
A6J62_RS12425	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6J62_RS12430	COG1466	dna polymerase III delta subunit
A6J62_RS12435	COG0799	negative regulation of ribosome biogenesis
A6J62_RS12440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J62_RS12445	COG0768	penicillin binding
A6J62_RS12450	COG0772	Belongs to the SEDS family
A6J62_RS12455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J62_RS12460	COG1686	Belongs to the peptidase S11 family
A6J62_RS12465	COG2921	Belongs to the UPF0250 family
A6J62_RS12470	COG0321	lipoyl(octanoyl) transferase activity
A6J62_RS12475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6J62_RS12485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J62_RS12510	COG1596	polysaccharide export
A6J62_RS12520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J62_RS12550	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6J62_RS12560	COG0438	transferase activity, transferring glycosyl groups
A6J62_RS12570	COG1045	serine acetyltransferase
A6J62_RS12590	COG0110	maltose O-acetyltransferase activity
A6J62_RS12595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6J62_RS12600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6J62_RS12605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J62_RS12610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J62_RS12640	COG0366	Alpha amylase catalytic
A6J62_RS12645	COG1263	PTS System
A6J62_RS12645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J62_RS12650	COG1609	Transcriptional regulator
A6J62_RS12655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J62_RS12660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J62_RS12665	COG2011	ABC-type metal ion transport system permease component
A6J62_RS12670	COG1464	Belongs to the NlpA lipoprotein family
A6J62_RS12675	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6J62_RS12685	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6J62_RS12685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6J62_RS12700	COG1611	Belongs to the LOG family
A6J62_RS12705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J62_RS12710	COG2363	Small membrane protein
A6J62_RS12715	COG0583	DNA-binding transcription factor activity
A6J62_RS12720	COG0301	tRNA thio-modification
A6J62_RS12720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J62_RS12730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6J62_RS12735	COG1722	exodeoxyribonuclease VII activity
A6J62_RS12740	COG0142	geranyltranstransferase activity
A6J62_RS12745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J62_RS12750	COG0564	pseudouridine synthase activity
A6J62_RS12755	COG3098	single-species biofilm formation
A6J62_RS12770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J62_RS12780	COG1671	Belongs to the UPF0178 family
A6J62_RS12785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6J62_RS12790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J62_RS12795	COG0254	rRNA binding
A6J62_RS12800	COG1720	tRNA m6t6A37 methyltransferase activity
A6J62_RS12805	COG0442	prolyl-tRNA aminoacylation
A6J62_RS12835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J62_RS12835	COG0047	phosphoribosylformylglycinamidine synthase activity
A6J62_RS12845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6J62_RS12855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6J62_RS12880	COG4968	Prepilin-type N-terminal cleavage methylation domain
A6J62_RS12890	COG0484	heat shock protein binding
A6J62_RS12895	COG0443	Heat shock 70 kDa protein
A6J62_RS12900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J62_RS12905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6J62_RS12910	COG0497	DNA recombination
A6J62_RS12915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J62_RS12920	COG2914	Belongs to the UPF0125 (RnfH) family
A6J62_RS12925	COG2867	negative regulation of translational initiation
A6J62_RS12930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J62_RS12940	COG0582	viral genome integration into host DNA
A6J62_RS12955	COG0582	viral genome integration into host DNA
A6J62_RS12960	COG3064	Membrane
A6J62_RS12970	COG0739	heme binding
A6J62_RS12990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A6J62_RS12995	COG2207	Transcriptional regulator
A6J62_RS13005	COG1459	type II secretion system
A6J62_RS13010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J62_RS13045	COG2165	general secretion pathway protein
A6J62_RS13055	COG3710	Transcriptional regulator
A6J62_RS13060	COG0840	transmembrane signaling receptor activity
A6J62_RS13065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6J62_RS13095	COG1012	belongs to the aldehyde dehydrogenase family
A6J62_RS13160	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6J62_RS13165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A6J62_RS13170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J62_RS13190	COG3051	citrate lyase alpha subunit
A6J62_RS13195	COG2301	Belongs to the HpcH HpaI aldolase family
A6J62_RS13205	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A6J62_RS13215	COG3630	sodium ion export across plasma membrane
A6J62_RS13220	COG0511	ligase activity, forming carbon-carbon bonds
A6J62_RS13220	COG5016	pyruvate
A6J62_RS13225	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6J62_RS13235	COG4565	transcriptional regulatory protein
A6J62_RS13250	COG0583	DNA-binding transcription factor activity
A6J62_RS13260	COG1115	amino acid carrier protein
A6J62_RS13265	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A6J62_RS13270	COG0583	DNA-binding transcription factor activity
A6J62_RS13280	COG1120	ATPase activity
A6J62_RS13285	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J62_RS13290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J62_RS13295	COG4592	Periplasmic binding protein
A6J62_RS13305	COG1028	Short-chain dehydrogenase reductase Sdr
A6J62_RS13310	COG1169	isochorismate synthase
A6J62_RS13315	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6J62_RS13320	COG3433	isochorismatase activity
A6J62_RS13320	COG1535	isochorismatase
A6J62_RS13325	COG1584	GPR1 FUN34 yaaH family protein
A6J62_RS13335	COG0519	Catalyzes the synthesis of GMP from XMP
A6J62_RS13335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6J62_RS13340	COG0516	GMP reductase activity
A6J62_RS13340	COG0517	IMP dehydrogenase activity
A6J62_RS13345	COG1570	exodeoxyribonuclease VII activity
A6J62_RS13360	COG1160	GTP binding
A6J62_RS13365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J62_RS13370	COG2976	Protein conserved in bacteria
A6J62_RS13375	COG0124	histidyl-tRNA synthetase
A6J62_RS13380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6J62_RS13390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J62_RS13395	COG0105	UTP biosynthetic process
A6J62_RS13400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J62_RS13405	COG2975	iron-sulfur cluster assembly
A6J62_RS13410	COG0633	Ferredoxin
A6J62_RS13415	COG0443	Heat shock 70 kDa protein
A6J62_RS13420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J62_RS13430	COG0822	iron-sulfur transferase activity
A6J62_RS13435	COG1104	cysteine desulfurase activity
A6J62_RS13440	COG1959	2 iron, 2 sulfur cluster binding
A6J62_RS13450	COG0483	inositol monophosphate 1-phosphatase activity
A6J62_RS13455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J62_RS13460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J62_RS13465	COG1862	Preprotein translocase
A6J62_RS13485	COG0517	IMP dehydrogenase activity
A6J62_RS13495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6J62_RS13500	COG0583	DNA-binding transcription factor activity
A6J62_RS13505	COG0450	alkyl hydroperoxide reductase
A6J62_RS13510	COG3142	Participates in the control of copper homeostasis
A6J62_RS13525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J62_RS13530	COG0581	inorganic phosphate transmembrane transporter activity
A6J62_RS13540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6J62_RS13545	COG0248	Ppx GppA phosphatase
A6J62_RS13560	COG0745	RESPONSE REGULATOR receiver
A6J62_RS13570	COG0826	peptidase U32
A6J62_RS13575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J62_RS13620	COG0542	response to heat
A6J62_RS13630	COG0564	pseudouridine synthase activity
A6J62_RS13635	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J62_RS13640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6J62_RS13645	COG1605	Chorismate mutase
A6J62_RS13645	COG0077	Prephenate dehydratase
A6J62_RS13650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6J62_RS13655	COG5001	Diguanylate cyclase
A6J62_RS13665	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A6J62_RS13675	COG0488	(ABC) transporter
A6J62_RS13685	COG1605	Chorismate mutase
A6J62_RS13685	COG0287	Prephenate dehydrogenase
A6J62_RS13690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J62_RS13695	COG3275	phosphorelay sensor kinase activity
A6J62_RS13700	COG3279	Response regulator of the LytR AlgR family
A6J62_RS13710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6J62_RS13715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6J62_RS13730	COG1966	Carbon starvation protein
A6J62_RS13735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6J62_RS13740	COG1047	Peptidyl-prolyl cis-trans
A6J62_RS13755	COG0196	riboflavin kinase activity
A6J62_RS13760	COG0728	peptidoglycan biosynthetic process
A6J62_RS13765	COG0268	Binds directly to 16S ribosomal RNA
A6J62_RS13770	COG0640	Transcriptional regulator
A6J62_RS13775	COG0583	DNA-binding transcription factor activity
A6J62_RS13780	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6J62_RS13790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6J62_RS13795	COG0730	response to heat
A6J62_RS13800	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A6J62_RS13805	COG0494	nUDIX hydrolase
A6J62_RS13815	COG0667	Aldo Keto reductase
A6J62_RS13825	COG2204	response regulator
A6J62_RS13830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6J62_RS13850	COG0513	Belongs to the DEAD box helicase family
A6J62_RS13875	COG3153	acetyltransferase
A6J62_RS13880	COG3154	lipid carrier protein
A6J62_RS13890	COG0826	peptidase U32
A6J62_RS13895	COG0826	peptidase U32
A6J62_RS13920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6J62_RS13930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J62_RS13935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J62_RS13940	COG0195	Participates in both transcription termination and antitermination
A6J62_RS13945	COG0779	Required for maturation of 30S ribosomal subunits
A6J62_RS13960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J62_RS13975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J62_RS13980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J62_RS13985	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6J62_RS13990	COG1534	Rna-binding protein
A6J62_RS13995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J62_RS14000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6J62_RS14010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J62_RS14015	COG0739	heme binding
A6J62_RS14030	COG0316	Belongs to the HesB IscA family
A6J62_RS14035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6J62_RS14040	COG0628	permease
A6J62_RS14050	COG0784	Response regulator, receiver
A6J62_RS14050	COG2205	protein histidine kinase activity
A6J62_RS14060	COG0747	negative chemotaxis
A6J62_RS14065	COG0601	transmembrane transport
A6J62_RS14070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J62_RS14075	COG0444	Belongs to the ABC transporter superfamily
A6J62_RS14080	COG4608	Belongs to the ABC transporter superfamily
A6J62_RS14090	COG2971	BadF BadG BcrA BcrD
A6J62_RS14110	COG3842	ATPase activity
A6J62_RS14120	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J62_RS14125	COG0004	ammonium transporteR
A6J62_RS14130	COG0347	Belongs to the P(II) protein family
A6J62_RS14135	COG3112	Uncharacterised protein family (UPF0231)
A6J62_RS14140	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6J62_RS14150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J62_RS14155	COG1643	Atp-dependent helicase
A6J62_RS14165	COG1489	DNA binding
A6J62_RS14175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J62_RS14185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J62_RS14190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6J62_RS14195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6J62_RS14200	COG0842	Transport permease protein
A6J62_RS14205	COG1131	(ABC) transporter
A6J62_RS14210	COG0659	secondary active sulfate transmembrane transporter activity
A6J62_RS14215	COG0288	reversible hydration of carbon dioxide
A6J62_RS14235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J62_RS14240	COG3107	peptidoglycan biosynthetic process
A6J62_RS14245	COG0792	nuclease activity
A6J62_RS14250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J62_RS14255	COG2823	Periplasmic or secreted lipoprotein
A6J62_RS14260	COG2969	positive regulation of protein catabolic process
A6J62_RS14265	COG0625	glutathione transferase activity
A6J62_RS14270	COG2857	Cytochrome c1
A6J62_RS14275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6J62_RS14280	COG0723	plastoquinol--plastocyanin reductase activity
A6J62_RS14285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J62_RS14290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J62_RS14295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6J62_RS14305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J62_RS14310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J62_RS14315	COG0335	large ribosomal subunit rRNA binding
A6J62_RS14320	COG0336	Belongs to the RNA methyltransferase TrmD family
A6J62_RS14325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6J62_RS14330	COG0228	four-way junction DNA binding
A6J62_RS14335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J62_RS14340	COG4137	Cytochrome C assembly protein
A6J62_RS14345	COG4536	flavin adenine dinucleotide binding
A6J62_RS14350	COG1854	S-ribosylhomocysteine lyase activity
A6J62_RS14355	COG2918	glutathione biosynthetic process
A6J62_RS14360	COG0612	Peptidase, M16
A6J62_RS14365	COG1238	metal cluster binding
A6J62_RS14375	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6J62_RS14380	COG5016	pyruvate
A6J62_RS14380	COG0511	ligase activity, forming carbon-carbon bonds
A6J62_RS14385	COG3630	sodium ion export across plasma membrane
A6J62_RS14430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6J62_RS14435	COG0527	aspartate kinase activity
A6J62_RS14440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J62_RS14450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J62_RS14460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6J62_RS14465	COG4208	sulfate ABC transporter
A6J62_RS14485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J62_RS14490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J62_RS14500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J62_RS14505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6J62_RS14510	COG0585	pseudouridine synthase activity
A6J62_RS14515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6J62_RS14520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6J62_RS14525	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6J62_RS14530	COG1968	undecaprenyl-diphosphatase activity
A6J62_RS14535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J62_RS14540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6J62_RS14550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J62_RS14560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J62_RS14565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J62_RS14570	COG1610	YqeY-like protein
A6J62_RS14575	COG0358	DNA primase activity
A6J62_RS14590	COG0582	viral genome integration into host DNA
A6J62_RS14595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6J62_RS14605	COG2207	Transcriptional regulator
A6J62_RS14610	COG0840	transmembrane signaling receptor activity
A6J62_RS14620	COG2003	Belongs to the UPF0758 family
A6J62_RS14655	COG0739	heme binding
A6J62_RS14665	COG4969	Belongs to the N-Me-Phe pilin family
A6J62_RS14680	COG0328	RNA-DNA hybrid ribonuclease activity
A6J62_RS14730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6J62_RS14740	COG1349	DNA-binding transcription factor activity
A6J62_RS14760	COG1279	arginine transmembrane transporter activity
A6J62_RS14765	COG0668	transmembrane transport
A6J62_RS14775	COG0191	fructose-bisphosphate aldolase activity
A6J62_RS14780	COG0126	phosphoglycerate kinase activity
A6J62_RS14785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J62_RS14790	COG4771	TonB-dependent receptor
A6J62_RS14795	COG0583	DNA-binding transcription factor activity
A6J62_RS14800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J62_RS14805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J62_RS14815	COG2356	endonuclease I
A6J62_RS14820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J62_RS14825	COG0189	ligase activity
A6J62_RS14830	COG1678	Uncharacterized ACR, COG1678
A6J62_RS14835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J62_RS14860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J62_RS14865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J62_RS14870	COG0762	integral membrane protein
A6J62_RS14875	COG1872	DUF167
A6J62_RS14885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J62_RS14890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J62_RS14895	COG2066	Belongs to the glutaminase family
A6J62_RS14905	COG1194	a g-specific adenine glycosylase
A6J62_RS14910	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A6J62_RS14915	COG0741	lytic transglycosylase activity
A6J62_RS14970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J62_RS14975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6J62_RS14980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J62_RS14985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6J62_RS14990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J62_RS14995	COG2967	ApaG domain
A6J62_RS15000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6J62_RS15010	COG3610	response to peptide
A6J62_RS15015	COG2966	Psort location CytoplasmicMembrane, score
A6J62_RS15020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J62_RS15025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J62_RS15030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6J62_RS15035	COG0142	geranyltranstransferase activity
A6J62_RS15040	COG0531	amino acid
A6J62_RS15045	COG0039	L-malate dehydrogenase activity
A6J62_RS15050	COG1438	arginine binding
A6J62_RS15060	COG2358	TRAP transporter, solute receptor (TAXI family
A6J62_RS15070	COG0589	response to stress
A6J62_RS15090	COG2235	arginine
A6J62_RS15095	COG0312	modulator of DNA gyrase
A6J62_RS15100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J62_RS15105	COG3164	Protein of unknown function
A6J62_RS15115	COG0424	maF-like protein
A6J62_RS15120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6J62_RS15125	COG1792	Involved in formation and maintenance of cell shape
A6J62_RS15130	COG1077	Cell shape determining protein MreB Mrl
A6J62_RS15160	COG2165	general secretion pathway protein
A6J62_RS15165	COG2165	general secretion pathway protein
A6J62_RS15175	COG1459	type II secretion system
A6J62_RS15180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J62_RS15190	COG3409	Peptidoglycan-binding domain 1 protein
A6J62_RS15190	COG3267	Type II secretory pathway component ExeA
A6J62_RS15215	COG2199	diguanylate cyclase activity
A6J62_RS15215	COG2200	EAL domain
A6J62_RS15220	COG0629	single-stranded DNA binding
A6J62_RS15235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J62_RS15245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6J62_RS15250	COG0527	aspartate kinase activity
A6J62_RS15255	COG0646	methionine synthase
A6J62_RS15255	COG1410	methionine synthase
A6J62_RS15330	COG0175	sulfate reduction
A6J62_RS15340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6J62_RS15365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J62_RS15370	COG0735	belongs to the Fur family
A6J62_RS15390	COG0432	Pfam Uncharacterised protein family UPF0047
A6J62_RS15395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J62_RS15410	COG0359	binds to the 23S rRNA
A6J62_RS15415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6J62_RS15420	COG2965	DNA replication, synthesis of RNA primer
A6J62_RS15425	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J62_RS15435	COG2906	2 iron, 2 sulfur cluster binding
A6J62_RS15440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J62_RS15445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J62_RS15450	COG0049	tRNA binding
A6J62_RS15465	COG2923	Belongs to the DsrF TusC family
A6J62_RS15470	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6J62_RS15475	COG2964	Protein conserved in bacteria
A6J62_RS15480	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J62_RS15490	COG2900	Belongs to the SlyX family
A6J62_RS15495	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6J62_RS15500	COG0330	HflC and HflK could
A6J62_RS15505	COG0330	HflC and HflK could
A6J62_RS15510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J62_RS15515	COG1923	regulation of RNA biosynthetic process
A6J62_RS15520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6J62_RS15525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J62_RS15535	COG0802	atpase or kinase
A6J62_RS15540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J62_RS15585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6J62_RS15595	COG0688	phosphatidylethanolamine metabolic process
A6J62_RS15610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6J62_RS15615	COG4942	peptidase
A6J62_RS15630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6J62_RS15635	COG2816	NAD+ diphosphatase activity
A6J62_RS15640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6J62_RS15645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J62_RS15650	COG0085	RNA polymerase activity
A6J62_RS15655	COG0222	ribosome binding
A6J62_RS15660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J62_RS15670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J62_RS15675	COG0250	Participates in transcription elongation, termination and antitermination
A6J62_RS15680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J62_RS15685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J62_RS15710	COG1072	(Pantothenic acid kinase))
A6J62_RS15720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J62_RS15730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J62_RS15780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6J62_RS15795	COG3118	belongs to the thioredoxin family
A6J62_RS15800	COG0513	Belongs to the DEAD box helicase family
A6J62_RS15805	COG0248	Ppx GppA phosphatase
A6J62_RS15810	COG0784	Response regulator, receiver
A6J62_RS15810	COG2205	protein histidine kinase activity
A6J62_RS15815	COG2814	Major facilitator Superfamily
A6J62_RS15835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J62_RS15840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6J62_RS15845	COG0511	ligase activity, forming carbon-carbon bonds
A6J62_RS15850	COG0439	Biotin carboxylase
A6J62_RS15855	COG2264	protein methyltransferase activity
A6J62_RS15860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J62_RS15865	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6J62_RS15875	COG0129	dihydroxy-acid dehydratase activity
A6J62_RS15880	COG3265	gluconokinase activity
A6J62_RS15890	COG0800	Aldolase
A6J62_RS15910	COG0840	transmembrane signaling receptor activity
A6J62_RS15915	COG1982	Orn Lys Arg decarboxylase major
A6J62_RS15920	COG0531	amino acid
A6J62_RS15925	COG3710	Transcriptional regulator
A6J62_RS15930	COG0789	Transcriptional regulator
A6J62_RS15945	COG0151	Belongs to the GarS family
A6J62_RS15955	COG0776	regulation of translation
A6J62_RS15960	COG1253	flavin adenine dinucleotide binding
A6J62_RS15965	COG1940	carbohydrate kinase activity
A6J62_RS15975	COG3068	Protein conserved in bacteria
A6J62_RS15985	COG1573	uracil-dna glycosylase
A6J62_RS15990	COG0668	transmembrane transport
A6J62_RS15995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6J62_RS16000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J62_RS16050	COG1012	belongs to the aldehyde dehydrogenase family
A6J62_RS16050	COG1454	alcohol dehydrogenase
A6J62_RS16055	COG0318	PFAM AMP-dependent synthetase and ligase
A6J62_RS16085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6J62_RS16090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J62_RS16095	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6J62_RS16095	COG0662	Cupin 2, conserved barrel domain protein
A6J62_RS16100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J62_RS16135	COG1519	Transferase
A6J62_RS16165	COG3642	lipopolysaccharide core region biosynthetic process
A6J62_RS16170	COG0859	PFAM glycosyl transferase family 9
A6J62_RS16175	COG0463	Glycosyl transferase, family 2
A6J62_RS16180	COG0859	PFAM glycosyl transferase family 9
A6J62_RS16185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J62_RS16190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6J62_RS16200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J62_RS16205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J62_RS16210	COG2003	Belongs to the UPF0758 family
A6J62_RS16220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J62_RS16230	COG1309	transcriptional regulator
A6J62_RS16235	COG1560	Kdo2-lipid A biosynthetic process
A6J62_RS16240	COG1560	Kdo2-lipid A biosynthetic process
A6J62_RS16245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J62_RS16250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6J62_RS16255	COG1561	YicC-like family, N-terminal region
A6J62_RS16260	COG2862	Uncharacterized protein family, UPF0114
A6J62_RS16265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J62_RS16265	COG1263	PTS System
A6J62_RS16270	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6J62_RS16295	COG1120	ATPase activity
A6J62_RS16300	COG4774	siderophore transport
A6J62_RS16305	COG1132	(ABC) transporter
A6J62_RS16320	COG0514	ATP-dependent DNA helicase (RecQ)
A6J62_RS16340	COG1280	lysine exporter protein (LysE YggA)
A6J62_RS16345	COG0210	DNA helicase
A6J62_RS16355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6J62_RS16360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J62_RS16400	COG3621	Patatin-like phospholipase
A6J62_RS16425	COG2131	deaminase
A6J62_RS16435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J62_RS16445	COG0747	negative chemotaxis
A6J62_RS16500	COG1309	transcriptional regulator
A6J62_RS16505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J62_RS16510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J62_RS16515	COG2960	long-chain fatty acid transporting porin activity
A6J62_RS16520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6J62_RS16525	COG0583	DNA-binding transcription factor activity
A6J62_RS16570	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A6J62_RS16575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J62_RS16580	COG1739	Uncharacterized protein family UPF0029
A6J62_RS16590	COG0183	Belongs to the thiolase family
A6J62_RS16595	COG0583	DNA-binding transcription factor activity
A6J62_RS16600	COG2814	Major facilitator Superfamily
A6J62_RS16605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J62_RS16610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J62_RS16615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6J62_RS16620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6J62_RS16625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6J62_RS16630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J62_RS16635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6J62_RS16645	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J62_RS16650	COG3312	ion transport
A6J62_RS16655	COG1475	DNA binding
A6J62_RS16660	COG1192	Involved in chromosome partitioning
A6J62_RS16670	COG0445	tRNA wobble uridine modification
A6J62_RS16680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6J62_RS16685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J62_RS16690	COG0706	membrane insertase activity
A6J62_RS16700	COG0594	ribonuclease P activity
A6J62_RS16705	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6J62_RS16710	COG1126	abc transporter atp-binding protein
A6J62_RS16725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J62_RS16730	COG0592	DNA-directed DNA polymerase activity
A6J62_RS16735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J62_RS16740	COG0187	DNA topoisomerase II activity
A6J62_RS16755	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J62_RS16760	COG3977	Valine--pyruvate aminotransferase
A6J62_RS16770	COG0751	glycine-tRNA ligase activity
A6J62_RS16775	COG0752	glycyl-tRNA synthetase alpha subunit
A6J62_RS16780	COG2119	membrane
A6J62_RS16790	COG0425	Belongs to the sulfur carrier protein TusA family
A6J62_RS16810	COG0129	dihydroxy-acid dehydratase activity
A6J62_RS16815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J62_RS16835	COG0204	Acyl-transferase
A6J62_RS16840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J62_RS16845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6J62_RS16860	COG3084	Protein conserved in bacteria
A6J62_RS16870	COG4326	sporulation control protein
A6J62_RS16875	COG1272	protein, Hemolysin III
A6J62_RS16885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J62_RS16890	COG0569	domain protein
A6J62_RS16895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J62_RS16895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J62_RS16900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J62_RS16905	COG0242	peptide deformylase activity
A6J62_RS16910	COG1652	LysM domain
A6J62_RS16915	COG0758	DNA mediated transformation
A6J62_RS16920	COG2922	Belongs to the Smg family
A6J62_RS16925	COG0551	DNA topoisomerase type I activity
A6J62_RS16930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J62_RS16935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J62_RS16940	COG0009	L-threonylcarbamoyladenylate synthase
A6J62_RS16945	COG0408	coproporphyrinogen oxidase activity
A6J62_RS16950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J62_RS16960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6J62_RS17000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J62_RS17005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6J62_RS17015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J62_RS17020	COG2104	thiamine diphosphate biosynthetic process
A6J62_RS17025	COG2022	thiamine diphosphate biosynthetic process
A6J62_RS17030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J62_RS17035	COG0006	proline dipeptidase activity
A6J62_RS17035	COG0006	proline dipeptidase activity
A6J62_RS17055	COG1522	sequence-specific DNA binding
A6J62_RS17060	COG5001	Diguanylate cyclase
A6J62_RS17060	COG5002	protein histidine kinase activity
A6J62_RS17080	COG0589	response to stress
A6J62_RS17090	COG1528	Iron-storage protein
A6J62_RS17100	COG2081	HI0933 family
A6J62_RS17110	COG1322	Protein conserved in bacteria
A6J62_RS17115	COG2226	methyltransferase
A6J62_RS17130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J62_RS17135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J62_RS17140	COG0805	protein transport
A6J62_RS17145	COG1858	cytochrome C peroxidase
A6J62_RS17150	COG0534	Mate efflux family protein
A6J62_RS17160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6J62_RS17175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6J62_RS17180	COG3161	chorismate lyase activity
A6J62_RS17190	COG1580	Controls the rotational direction of flagella during chemotaxis
A6J62_RS17195	COG0840	transmembrane signaling receptor activity
A6J62_RS17205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J62_RS17215	COG0084	hydrolase, TatD family'
A6J62_RS17230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J62_RS17230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J62_RS17250	COG3078	GTPase activator activity
A6J62_RS17265	COG3071	HemY protein
A6J62_RS17270	COG2959	enzyme of heme biosynthesis
A6J62_RS17275	COG1587	Uroporphyrinogen-III synthase
A6J62_RS17280	COG0181	hydroxymethylbilane synthase activity
A6J62_RS17295	COG1965	Belongs to the frataxin family
A6J62_RS17305	COG0019	diaminopimelate decarboxylase activity
A6J62_RS17310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6J62_RS17320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6J62_RS17325	COG1011	Hydrolase
A6J62_RS17330	COG2200	EAL domain
A6J62_RS17330	COG2199	diguanylate cyclase activity
A6J62_RS17330	COG3287	FIST C domain
A6J62_RS17350	COG0561	phosphatase activity
A6J62_RS17355	COG2267	carboxylic ester hydrolase activity
A6J62_RS17360	COG1280	lysine exporter protein (LysE YggA)
A6J62_RS17365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6J62_RS17370	COG0783	Belongs to the Dps family
A6J62_RS17410	COG0742	ribosomal rna small subunit methyltransferase
A6J62_RS17415	COG0552	protein localization to endoplasmic reticulum
A6J62_RS17420	COG2884	Cell division ATP-binding protein ftsE
A6J62_RS17425	COG2177	Part of the ABC transporter FtsEX involved in
A6J62_RS17430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J62_RS17435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J62_RS17455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J62_RS17460	COG4206	TonB-dependent receptor
A6J62_RS17465	COG1404	Belongs to the peptidase S8 family
A6J62_RS17470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J62_RS17545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6J62_RS17550	COG5001	Diguanylate cyclase
A6J62_RS17550	COG3300	MHYT domain
A6J62_RS17570	COG0174	glutamine synthetase
A6J62_RS17580	COG1217	gtp-binding protein TYPA
A6J62_RS17585	COG1660	Displays ATPase and GTPase activities
A6J62_RS17590	COG1295	ribonuclease BN
A6J62_RS17595	COG1490	D-aminoacyl-tRNA deacylase activity
A6J62_RS17600	COG0456	acetyltransferase
A6J62_RS17610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6J62_RS17615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6J62_RS17620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J62_RS17625	COG3031	protein transport across the cell outer membrane
A6J62_RS17635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J62_RS17640	COG1459	type II secretion system
A6J62_RS17645	COG2165	general secretion pathway protein
A6J62_RS17650	COG2165	general secretion pathway protein
A6J62_RS17655	COG2165	general secretion pathway protein
A6J62_RS17660	COG4795	General secretion pathway protein
A6J62_RS17665	COG3156	type II secretion system protein K
A6J62_RS17670	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6J62_RS17675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6J62_RS17685	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6J62_RS17690	COG0494	nUDIX hydrolase
A6J62_RS17700	COG1040	competence protein
A6J62_RS17705	COG0596	Alpha beta hydrolase
A6J62_RS17715	COG2183	response to ionizing radiation
A6J62_RS17720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J62_RS17735	COG2233	PERMEase
A6J62_RS17740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J62_RS17745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J62_RS17750	COG1758	RNA polymerase activity
A6J62_RS17755	COG0194	GDP metabolic process
A6J62_RS17760	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6J62_RS17765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J62_RS17785	COG4232	protein-disulfide reductase activity
A6J62_RS17800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J62_RS17805	COG1027	Aspartate ammonia-lyase
A6J62_RS17810	COG3706	GGDEF domain
A6J62_RS17815	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6J62_RS17820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6J62_RS17830	COG2205	protein histidine kinase activity
A6J62_RS17835	COG0745	RESPONSE REGULATOR receiver
A6J62_RS17845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J62_RS17850	COG0205	6-phosphofructokinase activity
A6J62_RS17855	COG1494	fructose-1,6-bisphosphatase
A6J62_RS17860	COG3074	FtsZ-dependent cytokinesis
A6J62_RS17865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6J62_RS17870	COG0460	homoserine dehydrogenase
A6J62_RS17870	COG0527	aspartate kinase activity
A6J62_RS17875	COG0626	cystathionine gamma-synthase activity
A6J62_RS17880	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6J62_RS17885	COG0281	malic enzyme
A6J62_RS17890	COG0254	rRNA binding
A6J62_RS17895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J62_RS17905	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J62_RS17910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6J62_RS17915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6J62_RS17920	COG1575	Belongs to the MenA family. Type 1 subfamily
A6J62_RS17925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6J62_RS17930	COG0534	Mate efflux family protein
A6J62_RS17935	COG0149	triose-phosphate isomerase activity
A6J62_RS17960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J62_RS17965	COG0459	protein refolding
A6J62_RS17975	COG1509	lysine 2,3-aminomutase activity
A6J62_RS17980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J62_RS17990	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6J62_RS17995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J62_RS18000	COG1053	succinate dehydrogenase
A6J62_RS18005	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6J62_RS18010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J62_RS18015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6J62_RS18020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6J62_RS18025	COG1045	serine acetyltransferase
A6J62_RS18035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6J62_RS18040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J62_RS18045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6J62_RS18050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J62_RS18055	COG0137	argininosuccinate synthase activity
A6J62_RS18065	COG0165	Argininosuccinate lyase
A6J62_RS18075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J62_RS18080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J62_RS18080	COG0678	peroxiredoxin activity
A6J62_RS18090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6J62_RS18120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J62_RS18125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6J62_RS18135	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6J62_RS18140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J62_RS18145	COG0546	phosphoglycolate phosphatase activity
A6J62_RS18150	COG0180	Tryptophanyl-tRNA synthetase
A6J62_RS18165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J62_RS18175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6J62_RS18185	COG1012	belongs to the aldehyde dehydrogenase family
A6J62_RS18200	COG3954	Phosphoribulokinase
A6J62_RS18210	COG0429	hydrolase of the alpha beta-hydrolase fold
A6J62_RS18220	COG0488	(ABC) transporter
A6J62_RS18225	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J62_RS18240	COG1047	Peptidyl-prolyl cis-trans
A6J62_RS18260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6J62_RS18265	COG3083	sulfuric ester hydrolase activity
A6J62_RS18270	COG0557	exoribonuclease II activity
A6J62_RS18275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J62_RS18280	COG0051	transcription antitermination factor activity, RNA binding
A6J62_RS18285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6J62_RS18290	COG0088	Forms part of the polypeptide exit tunnel
A6J62_RS18295	COG0089	rRNA binding
A6J62_RS18300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6J62_RS18305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6J62_RS18310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6J62_RS18315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J62_RS18320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6J62_RS18325	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J62_RS18330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J62_RS18335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J62_RS18340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J62_RS18345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6J62_RS18350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J62_RS18355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J62_RS18365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6J62_RS18370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6J62_RS18375	COG1841	ribosomal large subunit assembly
A6J62_RS18385	COG0201	protein transport
A6J62_RS18390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J62_RS18395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J62_RS18400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J62_RS18405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6J62_RS18410	COG0202	RNA polymerase activity
A6J62_RS18415	COG0203	ribosomal protein L17
A6J62_RS18425	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J62_RS18430	COG3266	domain, Protein
A6J62_RS18430	COG3061	Opacity-associated protein A
A6J62_RS18435	COG0697	spore germination
A6J62_RS18440	COG2153	protein acetylation
A6J62_RS18445	COG0513	Belongs to the DEAD box helicase family
A6J62_RS18455	COG0737	Belongs to the 5'-nucleotidase family
A6J62_RS18460	COG1648	precorrin-2 dehydrogenase activity
A6J62_RS18460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J62_RS18475	COG0529	Catalyzes the synthesis of activated sulfate
A6J62_RS18495	COG1136	(ABC) transporter
A6J62_RS18510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6J62_RS18515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J62_RS18520	COG0729	surface antigen
A6J62_RS18530	COG2105	PFAM AIG2 family protein
A6J62_RS18535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6J62_RS18550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J62_RS18555	COG0163	prenyltransferase activity
A6J62_RS18565	COG1178	ABC-type Fe3 transport system permease component
A6J62_RS18570	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6J62_RS18575	COG3028	Belongs to the UPF0307 family
A6J62_RS18580	COG0312	modulator of DNA gyrase
A6J62_RS18585	COG2239	Acts as a magnesium transporter
A6J62_RS18590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J62_RS18595	COG1660	Displays ATPase and GTPase activities
A6J62_RS18600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J62_RS18605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6J62_RS18615	COG1137	ATPase activity
A6J62_RS18620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6J62_RS18635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6J62_RS18635	COG0517	IMP dehydrogenase activity
A6J62_RS18650	COG1127	ABC transporter
A6J62_RS18655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J62_RS18660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J62_RS18665	COG2854	intermembrane phospholipid transfer
A6J62_RS18675	COG5007	Belongs to the BolA IbaG family
A6J62_RS18690	COG0251	oxidation-reduction process
A6J62_RS18700	COG0540	Belongs to the ATCase OTCase family
A6J62_RS18710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6J62_RS18725	COG0564	pseudouridine synthase activity
A6J62_RS18730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J62_RS18735	COG0525	valine-tRNA ligase activity
A6J62_RS18740	COG2927	DNA polymerase III (CHI subunit)
A6J62_RS18745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J62_RS18750	COG0795	lipopolysaccharide-transporting ATPase activity
A6J62_RS18755	COG0795	lipopolysaccharide-transporting ATPase activity
A6J62_RS18770	COG3437	response regulator, receiver
A6J62_RS18815	COG0066	3-isopropylmalate dehydratase activity
A6J62_RS18820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6J62_RS18825	COG0473	3-isopropylmalate dehydrogenase activity
A6J62_RS18850	COG0583	DNA-binding transcription factor activity
A6J62_RS18855	COG1022	Amp-dependent synthetase and ligase
A6J62_RS18860	COG0028	Belongs to the TPP enzyme family
A6J62_RS18865	COG0440	acetolactate synthase activity
A6J62_RS18875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6J62_RS18880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J62_RS18890	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6J62_RS18895	COG3079	Belongs to the UPF0149 family
A6J62_RS18900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J62_RS18905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J62_RS18920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6J62_RS18930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6J62_RS18940	COG1595	DNA-templated transcription, initiation
A6J62_RS18955	COG3086	response to oxidative stress
A6J62_RS18960	COG0481	GTPase activity
A6J62_RS18975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J62_RS18980	COG1381	Involved in DNA repair and RecF pathway recombination
A6J62_RS18985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6J62_RS19005	COG5001	Diguanylate cyclase
A6J62_RS19020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J62_RS19025	COG3956	TIGRFAM MazG family protein
A6J62_RS19030	COG0504	CTP synthase activity
A6J62_RS19035	COG0148	phosphopyruvate hydratase activity
A6J62_RS19045	COG3267	Type II secretory pathway component ExeA
A6J62_RS19045	COG3409	Peptidoglycan-binding domain 1 protein
A6J62_RS19055	COG4991	sh3 domain protein
A6J62_RS19060	COG0306	phosphate transporter
A6J62_RS19065	COG1392	Phosphate transport regulator
A6J62_RS19070	COG3025	triphosphatase activity
A6J62_RS19075	COG0840	transmembrane signaling receptor activity
A6J62_RS19080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6J62_RS19090	COG1538	Outer membrane efflux protein
A6J62_RS19095	COG0494	nUDIX hydrolase
A6J62_RS19100	COG3151	Protein conserved in bacteria
A6J62_RS19110	COG3150	esterase
A6J62_RS19115	COG0187	DNA topoisomerase II activity
A6J62_RS19120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J62_RS19130	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6J62_RS19135	COG0237	dephospho-CoA kinase activity
A6J62_RS19145	COG1459	type II secretion system
A6J62_RS19150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J62_RS19170	COG0716	FMN binding
A6J62_RS19175	COG4974	Belongs to the 'phage' integrase family
A6J62_RS19180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J62_RS19185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J62_RS19190	COG0737	Belongs to the 5'-nucleotidase family
A6J62_RS19200	COG2186	Transcriptional regulator
A6J62_RS19205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6J62_RS19210	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J62_RS19215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J62_RS19230	COG3116	cell division
A6J62_RS19235	COG0768	penicillin binding
A6J62_RS19240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J62_RS19245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J62_RS19255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J62_RS19260	COG0772	Belongs to the SEDS family
A6J62_RS19270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J62_RS19275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6J62_RS19280	COG0849	cell division
A6J62_RS19285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6J62_RS19290	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6J62_RS19300	COG0653	protein targeting
A6J62_RS19305	COG0494	nUDIX hydrolase
A6J62_RS19310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J62_RS19320	COG0505	Belongs to the CarA family
A6J62_RS19325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J62_RS19345	COG4172	Belongs to the ABC transporter superfamily
A6J62_RS19355	COG0730	response to heat
A6J62_RS19360	COG0583	DNA-binding transcription factor activity
A6J62_RS19365	COG2860	membrane
A6J62_RS19370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J62_RS19380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J62_RS19390	COG0493	'glutamate synthase