locus-tag	class	description
KW3_RS01000000119225	COG2009	succinate dehydrogenase
KW3_RS01000000119410	COG2906	2 iron, 2 sulfur cluster binding
KW3_RS01000000119560	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS01000000119610	COG0314	molybdopterin synthase activity
KW3_RS01000000119675	COG0010	Belongs to the arginase family
KW3_RS01000000119695	COG0322	excinuclease ABC activity
KW3_RS01000000119770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KW3_RS0100010	COG0646	methionine synthase
KW3_RS0100010	COG1410	methionine synthase
KW3_RS0100015	COG0527	aspartate kinase activity
KW3_RS0100020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KW3_RS0100030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KW3_RS0100045	COG0629	single-stranded DNA binding
KW3_RS0100050	COG2199	diguanylate cyclase activity
KW3_RS0100050	COG2200	EAL domain
KW3_RS0100075	COG3267	Type II secretory pathway component ExeA
KW3_RS0100075	COG3409	Peptidoglycan-binding domain 1 protein
KW3_RS0100085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KW3_RS0100090	COG1459	type II secretion system
KW3_RS0100100	COG2165	general secretion pathway protein
KW3_RS0100105	COG2165	general secretion pathway protein
KW3_RS0100135	COG1077	Cell shape determining protein MreB Mrl
KW3_RS0100140	COG1792	Involved in formation and maintenance of cell shape
KW3_RS0100145	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KW3_RS0100150	COG0424	maF-like protein
KW3_RS0100160	COG3164	Protein of unknown function
KW3_RS0100165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KW3_RS0100170	COG0312	modulator of DNA gyrase
KW3_RS0100175	COG2235	arginine
KW3_RS0100200	COG0589	response to stress
KW3_RS0100210	COG2358	TRAP transporter, solute receptor (TAXI family
KW3_RS0100215	COG1438	arginine binding
KW3_RS0100220	COG0039	L-malate dehydrogenase activity
KW3_RS0100225	COG0531	amino acid
KW3_RS0100230	COG0531	amino acid
KW3_RS0100235	COG0142	geranyltranstransferase activity
KW3_RS0100240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KW3_RS0100245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KW3_RS0100250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KW3_RS0100255	COG2966	Psort location CytoplasmicMembrane, score
KW3_RS0100260	COG3610	response to peptide
KW3_RS0100270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KW3_RS0100275	COG2967	ApaG domain
KW3_RS0100280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KW3_RS0100285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KW3_RS0100290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KW3_RS0100295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KW3_RS0100300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KW3_RS0100320	COG0840	transmembrane signaling receptor activity
KW3_RS0100345	COG0741	lytic transglycosylase activity
KW3_RS0100350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KW3_RS0100355	COG1194	a g-specific adenine glycosylase
KW3_RS0100365	COG2066	Belongs to the glutaminase family
KW3_RS0100375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KW3_RS0100380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KW3_RS0100390	COG1872	DUF167
KW3_RS0100395	COG0762	integral membrane protein
KW3_RS0100400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KW3_RS0100405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KW3_RS0100425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KW3_RS0100430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KW3_RS0100435	COG1678	Uncharacterized ACR, COG1678
KW3_RS0100440	COG0189	ligase activity
KW3_RS0100445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KW3_RS0100450	COG2356	endonuclease I
KW3_RS0100460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KW3_RS0100475	COG0583	DNA-binding transcription factor activity
KW3_RS0100480	COG4771	TonB-dependent receptor
KW3_RS0100485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KW3_RS0100490	COG0126	phosphoglycerate kinase activity
KW3_RS0100500	COG0191	fructose-bisphosphate aldolase activity
KW3_RS0100510	COG0668	transmembrane transport
KW3_RS0100515	COG1279	arginine transmembrane transporter activity
KW3_RS0100535	COG1349	DNA-binding transcription factor activity
KW3_RS0100540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KW3_RS0100545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KW3_RS0100595	COG2207	Transcriptional regulator
KW3_RS0100605	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KW3_RS0100610	COG0582	viral genome integration into host DNA
KW3_RS0100625	COG0358	DNA primase activity
KW3_RS0100630	COG1610	YqeY-like protein
KW3_RS0100635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KW3_RS0100640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KW3_RS0100650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KW3_RS0100655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KW3_RS0100660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KW3_RS0100665	COG1968	undecaprenyl-diphosphatase activity
KW3_RS0100670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KW3_RS0100675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KW3_RS0100680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KW3_RS0100685	COG0585	pseudouridine synthase activity
KW3_RS0100690	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KW3_RS0100695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KW3_RS0100705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KW3_RS0100710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KW3_RS0100730	COG4208	sulfate ABC transporter
KW3_RS0100735	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KW3_RS0100745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KW3_RS0100755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KW3_RS0100760	COG0527	aspartate kinase activity
KW3_RS0100765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KW3_RS0100815	COG3630	sodium ion export across plasma membrane
KW3_RS0100820	COG5016	pyruvate
KW3_RS0100820	COG0511	ligase activity, forming carbon-carbon bonds
KW3_RS0100825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KW3_RS0100835	COG1238	metal cluster binding
KW3_RS0100840	COG0612	Peptidase, M16
KW3_RS0100845	COG2918	glutathione biosynthetic process
KW3_RS0100850	COG1854	S-ribosylhomocysteine lyase activity
KW3_RS0100855	COG4536	flavin adenine dinucleotide binding
KW3_RS0100860	COG4137	Cytochrome C assembly protein
KW3_RS0100865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KW3_RS0100870	COG0228	four-way junction DNA binding
KW3_RS0100875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KW3_RS0100880	COG0336	Belongs to the RNA methyltransferase TrmD family
KW3_RS0100885	COG0335	large ribosomal subunit rRNA binding
KW3_RS0100890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KW3_RS0100895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KW3_RS0100905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KW3_RS0100910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KW3_RS0100915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KW3_RS0100920	COG0723	plastoquinol--plastocyanin reductase activity
KW3_RS0100925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KW3_RS0100930	COG2857	Cytochrome c1
KW3_RS0100935	COG0625	glutathione transferase activity
KW3_RS0100940	COG2969	positive regulation of protein catabolic process
KW3_RS0100945	COG2823	Periplasmic or secreted lipoprotein
KW3_RS0100950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KW3_RS0100955	COG0792	nuclease activity
KW3_RS0100960	COG3107	peptidoglycan biosynthetic process
KW3_RS0100965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KW3_RS0100980	COG0288	reversible hydration of carbon dioxide
KW3_RS0100985	COG0659	secondary active sulfate transmembrane transporter activity
KW3_RS0100990	COG1131	(ABC) transporter
KW3_RS0100995	COG0842	Transport permease protein
KW3_RS0101000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KW3_RS0101005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KW3_RS0101010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KW3_RS0101020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KW3_RS0101030	COG1489	DNA binding
KW3_RS0101040	COG1643	Atp-dependent helicase
KW3_RS0101045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KW3_RS0101050	COG1752	Esterase of the alpha-beta hydrolase superfamily
KW3_RS0101055	COG1049	propionate catabolic process, 2-methylcitrate cycle
KW3_RS0101060	COG3112	Uncharacterised protein family (UPF0231)
KW3_RS0101065	COG0347	Belongs to the P(II) protein family
KW3_RS0101070	COG0004	ammonium transporteR
KW3_RS0101075	COG1840	ABC-type Fe3 transport system, periplasmic component
KW3_RS0101085	COG3842	ATPase activity
KW3_RS0101105	COG2971	BadF BadG BcrA BcrD
KW3_RS0101115	COG4608	Belongs to the ABC transporter superfamily
KW3_RS0101120	COG0444	Belongs to the ABC transporter superfamily
KW3_RS0101125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KW3_RS0101130	COG0601	transmembrane transport
KW3_RS0101135	COG0747	negative chemotaxis
KW3_RS0101140	COG2205	protein histidine kinase activity
KW3_RS0101140	COG0784	Response regulator, receiver
KW3_RS0101145	COG2813	Specifically methylates the guanine in position
KW3_RS0101150	COG0628	permease
KW3_RS0101155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KW3_RS0101165	COG0316	Belongs to the HesB IscA family
KW3_RS0101180	COG0739	heme binding
KW3_RS0101185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KW3_RS0101190	COG2027	D-alanyl-D-alanine carboxypeptidase
KW3_RS0101195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KW3_RS0101200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KW3_RS0101205	COG1534	Rna-binding protein
KW3_RS0101210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KW3_RS0101215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KW3_RS0101220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KW3_RS0101230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KW3_RS0101245	COG0779	Required for maturation of 30S ribosomal subunits
KW3_RS0101250	COG0195	Participates in both transcription termination and antitermination
KW3_RS0101255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KW3_RS0101260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KW3_RS0101270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KW3_RS0101295	COG0826	peptidase U32
KW3_RS0101300	COG0826	peptidase U32
KW3_RS0101310	COG3154	lipid carrier protein
KW3_RS0101315	COG3153	acetyltransferase
KW3_RS0101430	COG3328	transposase activity
KW3_RS0101435	COG3328	transposase activity
KW3_RS0101450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KW3_RS0101585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KW3_RS0101600	COG0681	Belongs to the peptidase S26 family
KW3_RS0101640	COG2356	endonuclease I
KW3_RS0101655	COG0629	single-stranded DNA binding
KW3_RS0101675	COG0714	Associated with various cellular activities
KW3_RS0101700	COG2003	Belongs to the UPF0758 family
KW3_RS0101815	COG0513	Belongs to the DEAD box helicase family
KW3_RS0101830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KW3_RS0101835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KW3_RS0101840	COG2204	response regulator
KW3_RS0101850	COG0667	Aldo Keto reductase
KW3_RS0101865	COG0494	nUDIX hydrolase
KW3_RS0101870	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
KW3_RS0101875	COG0730	response to heat
KW3_RS0101880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KW3_RS0101890	COG1283	sodium-dependent phosphate transmembrane transporter activity
KW3_RS0101895	COG0583	DNA-binding transcription factor activity
KW3_RS0101900	COG0640	Transcriptional regulator
KW3_RS0101905	COG0268	Binds directly to 16S ribosomal RNA
KW3_RS0101910	COG0728	peptidoglycan biosynthetic process
KW3_RS0101915	COG0196	riboflavin kinase activity
KW3_RS0101930	COG1047	Peptidyl-prolyl cis-trans
KW3_RS0101935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KW3_RS0101940	COG1966	Carbon starvation protein
KW3_RS0101955	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KW3_RS0101960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KW3_RS0101970	COG3279	Response regulator of the LytR AlgR family
KW3_RS0101975	COG3275	phosphorelay sensor kinase activity
KW3_RS0101980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KW3_RS0101985	COG0287	Prephenate dehydrogenase
KW3_RS0101985	COG1605	Chorismate mutase
KW3_RS0101995	COG0488	(ABC) transporter
KW3_RS0102005	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
KW3_RS0102015	COG5001	Diguanylate cyclase
KW3_RS0102020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KW3_RS0102025	COG1605	Chorismate mutase
KW3_RS0102025	COG0077	Prephenate dehydratase
KW3_RS0102030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KW3_RS0102035	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KW3_RS0102040	COG0564	pseudouridine synthase activity
KW3_RS0102050	COG0542	response to heat
KW3_RS0102090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KW3_RS0102095	COG0826	peptidase U32
KW3_RS0102105	COG0745	RESPONSE REGULATOR receiver
KW3_RS0102110	COG5002	protein histidine kinase activity
KW3_RS0102120	COG0248	Ppx GppA phosphatase
KW3_RS0102125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KW3_RS0102135	COG0581	inorganic phosphate transmembrane transporter activity
KW3_RS0102140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KW3_RS0102155	COG3142	Participates in the control of copper homeostasis
KW3_RS0102160	COG0450	alkyl hydroperoxide reductase
KW3_RS0102165	COG0583	DNA-binding transcription factor activity
KW3_RS0102170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KW3_RS0102180	COG0517	IMP dehydrogenase activity
KW3_RS0102195	COG1862	Preprotein translocase
KW3_RS0102200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KW3_RS0102205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KW3_RS0102210	COG0483	inositol monophosphate 1-phosphatase activity
KW3_RS0102220	COG1959	2 iron, 2 sulfur cluster binding
KW3_RS0102225	COG1104	cysteine desulfurase activity
KW3_RS0102230	COG0822	iron-sulfur transferase activity
KW3_RS0102240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KW3_RS0102245	COG0443	Heat shock 70 kDa protein
KW3_RS0102250	COG0633	Ferredoxin
KW3_RS0102255	COG2975	iron-sulfur cluster assembly
KW3_RS0102260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KW3_RS0102265	COG0105	UTP biosynthetic process
KW3_RS0102270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KW3_RS0102280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KW3_RS0102285	COG0124	histidyl-tRNA synthetase
KW3_RS0102290	COG2976	Protein conserved in bacteria
KW3_RS0102295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KW3_RS0102300	COG1160	GTP binding
KW3_RS0102315	COG1570	exodeoxyribonuclease VII activity
KW3_RS0102320	COG0516	GMP reductase activity
KW3_RS0102320	COG0517	IMP dehydrogenase activity
KW3_RS0102325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KW3_RS0102325	COG0519	Catalyzes the synthesis of GMP from XMP
KW3_RS0102340	COG1584	GPR1 FUN34 yaaH family protein
KW3_RS0102345	COG1535	isochorismatase
KW3_RS0102345	COG3433	isochorismatase activity
KW3_RS0102350	COG1021	2,3-dihydroxybenzoate-AMP ligase
KW3_RS0102355	COG1169	isochorismate synthase
KW3_RS0102360	COG1028	Short-chain dehydrogenase reductase Sdr
KW3_RS0102370	COG4592	Periplasmic binding protein
KW3_RS0102375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KW3_RS0102380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KW3_RS0102385	COG1120	ATPase activity
KW3_RS0102395	COG0583	DNA-binding transcription factor activity
KW3_RS0102400	COG2015	COG2015, Alkyl sulfatase and related hydrolases
KW3_RS0102405	COG1115	amino acid carrier protein
KW3_RS0102415	COG0583	DNA-binding transcription factor activity
KW3_RS0102430	COG4565	transcriptional regulatory protein
KW3_RS0102440	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KW3_RS0102445	COG0511	ligase activity, forming carbon-carbon bonds
KW3_RS0102445	COG5016	pyruvate
KW3_RS0102450	COG3630	sodium ion export across plasma membrane
KW3_RS0102460	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
KW3_RS0102470	COG2301	Belongs to the HpcH HpaI aldolase family
KW3_RS0102475	COG3051	citrate lyase alpha subunit
KW3_RS0102495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KW3_RS0102500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KW3_RS0102505	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KW3_RS0102565	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS0102585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KW3_RS0102590	COG0840	transmembrane signaling receptor activity
KW3_RS0102595	COG3710	Transcriptional regulator
KW3_RS0102605	COG2165	general secretion pathway protein
KW3_RS0102620	COG4796	Type ii and iii secretion system protein
KW3_RS0102640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KW3_RS0102645	COG1459	type II secretion system
KW3_RS0102685	COG0739	heme binding
KW3_RS0102695	COG3064	Membrane
KW3_RS0102705	COG0582	viral genome integration into host DNA
KW3_RS0102710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KW3_RS0102715	COG2867	negative regulation of translational initiation
KW3_RS0102720	COG2914	Belongs to the UPF0125 (RnfH) family
KW3_RS0102725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KW3_RS0102730	COG0497	DNA recombination
KW3_RS0102735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KW3_RS0102740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KW3_RS0102745	COG0443	Heat shock 70 kDa protein
KW3_RS0102750	COG0484	heat shock protein binding
KW3_RS0102780	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KW3_RS0102795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KW3_RS0102805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KW3_RS0102805	COG0047	phosphoribosylformylglycinamidine synthase activity
KW3_RS0102830	COG0442	prolyl-tRNA aminoacylation
KW3_RS0102835	COG1720	tRNA m6t6A37 methyltransferase activity
KW3_RS0102840	COG0254	rRNA binding
KW3_RS0102845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KW3_RS0102850	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KW3_RS0102855	COG1671	Belongs to the UPF0178 family
KW3_RS0102865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KW3_RS0102880	COG3098	single-species biofilm formation
KW3_RS0102885	COG0564	pseudouridine synthase activity
KW3_RS0102890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KW3_RS0102895	COG0142	geranyltranstransferase activity
KW3_RS0102900	COG1722	exodeoxyribonuclease VII activity
KW3_RS0102905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KW3_RS0102915	COG0301	tRNA thio-modification
KW3_RS0102915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KW3_RS0102925	COG0583	DNA-binding transcription factor activity
KW3_RS0102930	COG2363	Small membrane protein
KW3_RS0102935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KW3_RS0102940	COG1611	Belongs to the LOG family
KW3_RS0102955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KW3_RS0102955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KW3_RS0102965	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KW3_RS0102970	COG1464	Belongs to the NlpA lipoprotein family
KW3_RS0102975	COG2011	ABC-type metal ion transport system permease component
KW3_RS0102980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KW3_RS0102985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KW3_RS0102990	COG1609	Transcriptional regulator
KW3_RS0102995	COG1263	PTS System
KW3_RS0102995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KW3_RS0103000	COG0366	Alpha amylase catalytic
KW3_RS0103025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KW3_RS0103030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KW3_RS0103035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KW3_RS0103040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KW3_RS0103045	COG0110	maltose O-acetyltransferase activity
KW3_RS0103065	COG1045	serine acetyltransferase
KW3_RS0103075	COG0438	transferase activity, transferring glycosyl groups
KW3_RS0103085	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KW3_RS0103115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KW3_RS0103125	COG1596	polysaccharide export
KW3_RS0103150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KW3_RS0103160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KW3_RS0103165	COG0321	lipoyl(octanoyl) transferase activity
KW3_RS0103170	COG2921	Belongs to the UPF0250 family
KW3_RS0103175	COG1686	Belongs to the peptidase S11 family
KW3_RS0103180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KW3_RS0103185	COG0772	Belongs to the SEDS family
KW3_RS0103190	COG0768	penicillin binding
KW3_RS0103195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KW3_RS0103200	COG0799	negative regulation of ribosome biogenesis
KW3_RS0103205	COG1466	dna polymerase III delta subunit
KW3_RS0103210	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
KW3_RS0103215	COG0495	leucyl-tRNA aminoacylation
KW3_RS0103220	COG2888	peptidyl-tyrosine sulfation
KW3_RS0103225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KW3_RS0103230	COG4535	Mg2 and Co2 transporter CorC
KW3_RS0103240	COG1702	phosphate starvation-inducible protein PhoH
KW3_RS0103245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KW3_RS0103250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KW3_RS0103255	COG2190	(PTS) system
KW3_RS0103265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KW3_RS0103270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KW3_RS0103275	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
KW3_RS0103280	COG3115	cell septum assembly
KW3_RS0103285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KW3_RS0103300	COG0789	Transcriptional regulator
KW3_RS0103305	COG1585	Membrane protein implicated in regulation of membrane protease activity
KW3_RS0103310	COG0330	HflC and HflK could
KW3_RS0103315	COG3118	belongs to the thioredoxin family
KW3_RS0103325	COG0300	oxidoreductase activity
KW3_RS0103330	COG1090	epimerase
KW3_RS0103335	COG0622	Phosphoesterase
KW3_RS0103350	COG3710	Transcriptional regulator
KW3_RS0103355	COG0326	Molecular chaperone. Has ATPase activity
KW3_RS0103360	COG0563	adenylate kinase activity
KW3_RS0103365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KW3_RS0103380	COG0367	asparagine synthase
KW3_RS0103385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KW3_RS0103385	COG4651	solute:proton antiporter activity
KW3_RS0103390	COG1940	carbohydrate kinase activity
KW3_RS0103390	COG1846	Transcriptional regulator
KW3_RS0103395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KW3_RS0103400	COG1263	PTS System
KW3_RS0103400	COG2190	(PTS) system
KW3_RS0103400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KW3_RS0103420	COG0101	tRNA pseudouridine synthase activity
KW3_RS0103425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KW3_RS0103430	COG0285	dihydrofolate synthase activity
KW3_RS0103435	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
KW3_RS0103440	COG1286	toxin biosynthetic process
KW3_RS0103445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KW3_RS0103450	COG2056	Na+-H+ antiporter family
KW3_RS0103455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KW3_RS0103475	COG0346	lactoylglutathione lyase activity
KW3_RS0103480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KW3_RS0103505	COG2878	Part of a membrane complex involved in electron transport
KW3_RS0103510	COG4657	Part of a membrane complex involved in electron transport
KW3_RS0103525	COG0556	nucleotide-excision repair
KW3_RS0103535	COG2204	response regulator
KW3_RS0103540	COG2198	Histidine kinase
KW3_RS0103545	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KW3_RS0103550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KW3_RS0103555	COG0521	Mo-molybdopterin cofactor biosynthetic process
KW3_RS0103560	COG0315	cyclic pyranopterin monophosphate synthase activity
KW3_RS0103565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KW3_RS0103570	COG0314	molybdopterin synthase activity
KW3_RS0103575	COG2199	diguanylate cyclase activity
KW3_RS0103580	COG0517	IMP dehydrogenase activity
KW3_RS0103580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KW3_RS0103580	COG0617	tRNA 3'-terminal CCA addition
KW3_RS0103590	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KW3_RS0103600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KW3_RS0103600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KW3_RS0103605	COG0489	protein tyrosine kinase activity
KW3_RS0103615	COG0572	uridine kinase
KW3_RS0103620	COG2982	Protein involved in outer membrane biogenesis
KW3_RS0103625	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KW3_RS0103630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KW3_RS0103640	COG2067	long-chain fatty acid transport protein
KW3_RS0103665	COG0183	Belongs to the thiolase family
KW3_RS0103670	COG1024	Enoyl-CoA hydratase
KW3_RS0103670	COG1250	3-hydroxyacyl-CoA dehydrogenase
KW3_RS0103675	COG0778	Nitroreductase
KW3_RS0103680	COG0583	DNA-binding transcription factor activity
KW3_RS0103685	COG0745	RESPONSE REGULATOR receiver
KW3_RS0103695	COG2832	Protein of unknown function (DUF454)
KW3_RS0103700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KW3_RS0103710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KW3_RS0103715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KW3_RS0103725	COG2983	Belongs to the UPF0260 family
KW3_RS0103730	COG1028	Short-chain dehydrogenase reductase Sdr
KW3_RS0103735	COG0616	signal peptide processing
KW3_RS0103745	COG1522	sequence-specific DNA binding
KW3_RS0103750	COG1946	Acyl-CoA thioesterase
KW3_RS0103770	COG3706	GGDEF domain
KW3_RS0103775	COG0640	Transcriptional regulator
KW3_RS0103780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KW3_RS0103805	COG1881	PFAM PEBP family protein
KW3_RS0103825	COG0009	L-threonylcarbamoyladenylate synthase
KW3_RS0103840	COG2201	protein-glutamate methylesterase activity
KW3_RS0103850	COG5002	protein histidine kinase activity
KW3_RS0103855	COG4191	Histidine kinase
KW3_RS0103860	COG5001	Diguanylate cyclase
KW3_RS0103860	COG3300	MHYT domain
KW3_RS0103865	COG2204	response regulator
KW3_RS0103885	COG0601	transmembrane transport
KW3_RS0103890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KW3_RS0103895	COG0444	Belongs to the ABC transporter superfamily
KW3_RS0103900	COG4608	Belongs to the ABC transporter superfamily
KW3_RS0103905	COG0435	Glutathione S-transferase
KW3_RS0103910	COG0280	phosphate acetyltransferase
KW3_RS0103910	COG0857	belongs to the CobB CobQ family
KW3_RS0103915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KW3_RS0103920	COG3092	negative regulation of chromosome organization
KW3_RS0103925	COG4628	conserved protein (DUF2132)
KW3_RS0103935	COG4120	Belongs to the binding-protein-dependent transport system permease family
KW3_RS0103945	COG2199	diguanylate cyclase activity
KW3_RS0103945	COG2203	Gaf domain
KW3_RS0103950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KW3_RS0103960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KW3_RS0103965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KW3_RS0103970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KW3_RS0103975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KW3_RS0103980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KW3_RS0103985	COG0156	8-amino-7-oxononanoate synthase activity
KW3_RS0103990	COG2226	methyltransferase
KW3_RS0103995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KW3_RS0104005	COG0501	Belongs to the peptidase M48B family
KW3_RS0104015	COG0300	oxidoreductase activity
KW3_RS0104030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KW3_RS0104040	COG2268	Band 7 protein
KW3_RS0104050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KW3_RS0104055	COG2915	High frequency lysogenization protein hflD homolog
KW3_RS0104060	COG0482	sulfurtransferase activity
KW3_RS0104065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KW3_RS0104070	COG2916	Histone family protein nucleoid-structuring protein H-NS
KW3_RS0104075	COG1757	Na H antiporter
KW3_RS0104080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KW3_RS0104085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KW3_RS0104090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KW3_RS0104095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KW3_RS0104095	COG0131	Imidazoleglycerol-phosphate dehydratase
KW3_RS0104100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KW3_RS0104105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KW3_RS0104110	COG0107	imidazoleglycerol-phosphate synthase activity
KW3_RS0104115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KW3_RS0104115	COG0140	phosphoribosyl-ATP diphosphatase activity
KW3_RS0104120	COG1187	pseudouridine synthase activity
KW3_RS0104130	COG1278	Cold shock
KW3_RS0104135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KW3_RS0104140	COG0542	response to heat
KW3_RS0104145	COG2985	domain, Protein
KW3_RS0104145	COG3273	potassium ion transport
KW3_RS0104150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KW3_RS0104155	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS0104155	COG1454	alcohol dehydrogenase
KW3_RS0104160	COG1737	Transcriptional regulator
KW3_RS0104165	COG0076	glutamate decarboxylase activity
KW3_RS0104175	COG2431	L-lysine efflux transmembrane transporter activity
KW3_RS0104185	COG3070	regulator of competence-specific genes
KW3_RS0104200	COG3852	Histidine kinase
KW3_RS0104210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KW3_RS0104225	COG0189	ligase activity
KW3_RS0104225	COG4067	protein conserved in archaea
KW3_RS0104230	COG0500	methyltransferase
KW3_RS0104235	COG4106	trans-aconitate 2-methyltransferase activity
KW3_RS0104240	COG1801	Protein of unknown function DUF72
KW3_RS0104245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KW3_RS0104250	COG1435	thymidine kinase activity
KW3_RS0104260	COG0159	tryptophan synthase activity
KW3_RS0104265	COG0133	tryptophan synthase activity
KW3_RS0104270	COG0135	phosphoribosylanthranilate isomerase activity
KW3_RS0104270	COG0134	indole-3-glycerol-phosphate synthase activity
KW3_RS0104275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KW3_RS0104280	COG0512	Glutamine amidotransferase of anthranilate synthase
KW3_RS0104285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KW3_RS0104295	COG0613	PHP domain protein
KW3_RS0104300	COG0009	L-threonylcarbamoyladenylate synthase
KW3_RS0104305	COG1187	pseudouridine synthase activity
KW3_RS0104310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KW3_RS0104315	COG4988	ABC transporter
KW3_RS0104320	COG0492	ferredoxin-NADP+ reductase activity
KW3_RS0104330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KW3_RS0104340	COG2949	membrane
KW3_RS0104350	COG0281	malic enzyme
KW3_RS0104360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KW3_RS0104380	COG2885	chlorophyll binding
KW3_RS0104395	COG0247	lactate metabolic process
KW3_RS0104395	COG0277	FAD linked oxidase domain protein
KW3_RS0104415	COG2986	histidine ammonia-lyase
KW3_RS0104420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KW3_RS0104425	COG0010	Belongs to the arginase family
KW3_RS0104430	COG1228	amidohydrolase
KW3_RS0104445	COG3099	Belongs to the UPF0263 family
KW3_RS0104450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KW3_RS0104460	COG5001	Diguanylate cyclase
KW3_RS0104465	COG0417	DNA replication proofreading
KW3_RS0104470	COG2197	response regulator
KW3_RS0104475	COG0322	excinuclease ABC activity
KW3_RS0104515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KW3_RS0104520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KW3_RS0104520	COG0072	phenylalanine-tRNA ligase activity
KW3_RS0104525	COG0776	regulation of translation
KW3_RS0104560	COG1346	cytolysis
KW3_RS0104565	COG1380	Effector of murein hydrolase LrgA
KW3_RS0104570	COG2925	Exonuclease
KW3_RS0104575	COG1823	symporter activity
KW3_RS0104580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KW3_RS0104590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KW3_RS0104595	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KW3_RS0104615	COG4139	cobalamin transport
KW3_RS0104665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KW3_RS0104670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KW3_RS0104675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KW3_RS0104685	COG1054	Belongs to the UPF0176 family
KW3_RS0104695	COG2814	Major facilitator Superfamily
KW3_RS0104705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KW3_RS0104730	COG2989	Protein conserved in bacteria
KW3_RS0104735	COG3108	Peptidase M15
KW3_RS0104740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KW3_RS0104755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KW3_RS0104780	COG1846	Transcriptional regulator
KW3_RS0104785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KW3_RS0104790	COG0726	polysaccharide deacetylase
KW3_RS0104795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KW3_RS0104805	COG1447	Phosphotransferase system cellobiose-specific component IIA
KW3_RS0104810	COG1486	melibiose metabolic process
KW3_RS0104820	COG1609	Transcriptional regulator
KW3_RS0104825	COG2943	transferase activity, transferring hexosyl groups
KW3_RS0104830	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KW3_RS0104835	COG0840	transmembrane signaling receptor activity
KW3_RS0104850	COG1448	Aminotransferase
KW3_RS0104860	COG3437	response regulator, receiver
KW3_RS0104860	COG2770	Histidine kinase
KW3_RS0104865	COG0351	phosphomethylpyrimidine kinase
KW3_RS0104870	COG0017	Asparaginyl-tRNA synthetase
KW3_RS0104875	COG0840	transmembrane signaling receptor activity
KW3_RS0104880	COG0720	synthase
KW3_RS0104885	COG1760	l-serine dehydratase
KW3_RS0104890	COG0814	amino acid
KW3_RS0104895	COG0494	nUDIX hydrolase
KW3_RS0104900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KW3_RS0104915	COG3106	COG3106 Predicted ATPase
KW3_RS0104920	COG3768	UPF0283 membrane protein
KW3_RS0104930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KW3_RS0104945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KW3_RS0104955	COG0471	metal ion transport
KW3_RS0104960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KW3_RS0104960	COG4191	Histidine kinase
KW3_RS0104970	COG2990	Protein conserved in bacteria
KW3_RS0104975	COG3713	MltA-interacting MipA family protein
KW3_RS0104980	COG2205	protein histidine kinase activity
KW3_RS0104985	COG0745	RESPONSE REGULATOR receiver
KW3_RS0105010	COG1129	ABC transporter
KW3_RS0105050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KW3_RS0105055	COG0372	Belongs to the citrate synthase family
KW3_RS0105085	COG2195	Cleaves the N-terminal amino acid of tripeptides
KW3_RS0105100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KW3_RS0105110	COG0625	glutathione transferase activity
KW3_RS0105115	COG3437	response regulator, receiver
KW3_RS0105130	COG3706	GGDEF domain
KW3_RS0105135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KW3_RS0105140	COG1254	Belongs to the acylphosphatase family
KW3_RS0105145	COG2920	part of a sulfur-relay system
KW3_RS0105150	COG0670	Belongs to the BI1 family
KW3_RS0105155	COG1126	abc transporter atp-binding protein
KW3_RS0105160	COG0765	amino acid transport
KW3_RS0105165	COG4597	amino acid ABC transporter
KW3_RS0105170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KW3_RS0105180	COG0561	phosphatase activity
KW3_RS0105185	COG0602	queuosine metabolic process
KW3_RS0105190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KW3_RS0105220	COG3706	GGDEF domain
KW3_RS0105225	COG0443	Heat shock 70 kDa protein
KW3_RS0105230	COG0443	Heat shock 70 kDa protein
KW3_RS0105260	COG1643	Atp-dependent helicase
KW3_RS0105270	COG0443	Heat shock 70 kDa protein
KW3_RS0105275	COG0095	Lipoate-protein ligase
KW3_RS0105280	COG0583	DNA-binding transcription factor activity
KW3_RS0105285	COG0477	Major facilitator Superfamily
KW3_RS0105290	COG0415	Belongs to the DNA photolyase family
KW3_RS0105305	COG0745	RESPONSE REGULATOR receiver
KW3_RS0105315	COG2198	Histidine kinase
KW3_RS0105315	COG0643	Histidine kinase
KW3_RS0105320	COG2198	Histidine kinase
KW3_RS0105320	COG0643	Histidine kinase
KW3_RS0105320	COG0784	Response regulator, receiver
KW3_RS0105325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KW3_RS0105335	COG2201	protein-glutamate methylesterase activity
KW3_RS0105340	COG0835	chemotaxis
KW3_RS0105345	COG0840	transmembrane signaling receptor activity
KW3_RS0105345	COG3290	protein histidine kinase activity
KW3_RS0105350	COG0840	transmembrane signaling receptor activity
KW3_RS0105360	COG0513	Belongs to the DEAD box helicase family
KW3_RS0105370	COG1538	Outer membrane efflux protein
KW3_RS0105375	COG1566	PFAM secretion protein HlyD family protein
KW3_RS0105380	COG2814	Major facilitator Superfamily
KW3_RS0105390	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KW3_RS0105400	COG3501	Rhs element vgr protein
KW3_RS0105410	COG3675	Pfam Lipase (class 3)
KW3_RS0105425	COG1280	lysine exporter protein (LysE YggA)
KW3_RS0105430	COG1115	amino acid carrier protein
KW3_RS0105445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KW3_RS0105455	COG1177	transmembrane transport
KW3_RS0105465	COG3842	ATPase activity
KW3_RS0105490	COG0589	response to stress
KW3_RS0105495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KW3_RS0105510	COG2217	Heavy metal translocating P-type atpase
KW3_RS0105520	COG2010	Cytochrome c
KW3_RS0105535	COG3278	Belongs to the heme-copper respiratory oxidase family
KW3_RS0105550	COG2205	protein histidine kinase activity
KW3_RS0105550	COG0784	Response regulator, receiver
KW3_RS0105575	COG2994	toxin metabolic process
KW3_RS0105580	COG1073	alpha beta
KW3_RS0105580	COG3064	Membrane
KW3_RS0105580	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
KW3_RS0105595	COG4128	Pfam Zonular occludens toxin
KW3_RS0105630	COG1476	TRANSCRIPTIONal
KW3_RS0105650	COG1476	TRANSCRIPTIONal
KW3_RS0105730	COG3328	transposase activity
KW3_RS0105745	COG3120	sequence-specific DNA binding
KW3_RS0105750	COG1067	ATP-dependent peptidase activity
KW3_RS0105755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KW3_RS0105765	COG0488	(ABC) transporter
KW3_RS0105775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KW3_RS0105775	COG0116	Belongs to the methyltransferase superfamily
KW3_RS0105785	COG0167	dihydroorotate dehydrogenase activity
KW3_RS0105800	COG0308	aminopeptidase N
KW3_RS0105815	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KW3_RS0105820	COG1956	GAF domain-containing protein
KW3_RS0105825	COG1132	(ABC) transporter
KW3_RS0105830	COG2995	paraquat-inducible protein a
KW3_RS0105835	COG3008	intermembrane lipid transfer
KW3_RS0105845	COG2996	Protein conserved in bacteria
KW3_RS0105860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KW3_RS0105865	COG1666	GTP binding
KW3_RS0105870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KW3_RS0105885	COG0437	4 iron, 4 sulfur cluster binding
KW3_RS0105890	COG0243	molybdopterin cofactor binding
KW3_RS0105890	COG3383	formate dehydrogenase (NAD+) activity
KW3_RS0105920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KW3_RS0105925	COG0488	(ABC) transporter
KW3_RS0105930	COG3852	Histidine kinase
KW3_RS0105935	COG2204	response regulator
KW3_RS0105945	COG4662	Binding-protein-dependent transport system inner membrane component
KW3_RS0105950	COG3842	ATPase activity
KW3_RS0105955	COG0746	molybdenum cofactor guanylyltransferase activity
KW3_RS0105985	COG1940	carbohydrate kinase activity
KW3_RS0105990	COG3148	PFAM DTW domain containing protein
KW3_RS0106000	COG0840	transmembrane signaling receptor activity
KW3_RS0106005	COG0791	NLP P60 protein
KW3_RS0106015	COG3001	Fructosamine kinase
KW3_RS0106025	COG0534	Mate efflux family protein
KW3_RS0106035	COG1793	dna ligase
KW3_RS0106045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KW3_RS0106050	COG0848	biopolymer transport protein
KW3_RS0106055	COG0811	peptide transport
KW3_RS0106060	COG0811	peptide transport
KW3_RS0106075	COG1175	transmembrane transport
KW3_RS0106080	COG0395	ABC-type sugar transport system, permease component
KW3_RS0106085	COG3842	ATPase activity
KW3_RS0106090	COG1349	DNA-binding transcription factor activity
KW3_RS0106095	COG0584	glycerophosphoryl diester phosphodiesterase
KW3_RS0106100	COG2731	YhcH YjgK YiaL family protein
KW3_RS0106105	COG0251	oxidation-reduction process
KW3_RS0106110	COG1609	Transcriptional regulator
KW3_RS0106115	COG2723	6-phospho-beta-galactosidase activity
KW3_RS0106125	COG0583	DNA-binding transcription factor activity
KW3_RS0106145	COG0577	efflux transmembrane transporter activity
KW3_RS0106145	COG1136	(ABC) transporter
KW3_RS0106150	COG0577	efflux transmembrane transporter activity
KW3_RS0106150	COG1136	(ABC) transporter
KW3_RS0106155	COG4591	ABC-type transport system involved in lipoprotein release permease component
KW3_RS0106155	COG1136	(ABC) transporter
KW3_RS0106160	COG1294	oxidase, subunit
KW3_RS0106165	COG1271	oxidase subunit
KW3_RS0106205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KW3_RS0106215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KW3_RS0106235	COG0753	catalase activity
KW3_RS0106265	COG2199	diguanylate cyclase activity
KW3_RS0106265	COG2200	EAL domain
KW3_RS0106275	COG2017	converts alpha-aldose to the beta-anomer
KW3_RS0106280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KW3_RS0106285	COG1085	galactose-1-phosphate uridylyltransferase
KW3_RS0106330	COG0835	chemotaxis
KW3_RS0106330	COG0784	Response regulator, receiver
KW3_RS0106340	COG4565	transcriptional regulatory protein
KW3_RS0106345	COG3290	protein histidine kinase activity
KW3_RS0106360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KW3_RS0106380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KW3_RS0106385	COG3063	Type IV pilus biogenesis stability protein PilW
KW3_RS0106395	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KW3_RS0106400	COG1451	nucleotide metabolic process
KW3_RS0106410	COG0583	DNA-binding transcription factor activity
KW3_RS0106440	COG1538	Outer membrane efflux protein
KW3_RS0106455	COG1748	Saccharopine dehydrogenase
KW3_RS0106465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KW3_RS0106475	COG0577	efflux transmembrane transporter activity
KW3_RS0106480	COG4181	ATPase activity
KW3_RS0106485	COG0534	Mate efflux family protein
KW3_RS0106490	COG0702	epimerase
KW3_RS0106500	COG2814	Major facilitator Superfamily
KW3_RS0106505	COG1187	pseudouridine synthase activity
KW3_RS0106510	COG1061	Type III restriction enzyme res subunit
KW3_RS0106530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KW3_RS0106535	COG2203	Gaf domain
KW3_RS0106535	COG3706	GGDEF domain
KW3_RS0106535	COG4251	negative regulation of phosphorylation
KW3_RS0106535	COG5001	Diguanylate cyclase
KW3_RS0106550	COG0840	transmembrane signaling receptor activity
KW3_RS0106595	COG2205	protein histidine kinase activity
KW3_RS0106595	COG0784	Response regulator, receiver
KW3_RS0106600	COG2239	Acts as a magnesium transporter
KW3_RS0106615	COG0814	amino acid
KW3_RS0106620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KW3_RS0106625	COG1131	(ABC) transporter
KW3_RS0106630	COG0842	Transport permease protein
KW3_RS0106640	COG3313	Fe-S protein
KW3_RS0106650	COG4134	Bacterial extracellular solute-binding protein
KW3_RS0106655	COG4135	transport system, permease component
KW3_RS0106660	COG4136	ATPase activity
KW3_RS0106665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KW3_RS0106670	COG0564	pseudouridine synthase activity
KW3_RS0106675	COG0733	neurotransmitter:sodium symporter activity
KW3_RS0106685	COG0626	cystathionine gamma-synthase activity
KW3_RS0106690	COG2818	Glycosylase
KW3_RS0106705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KW3_RS0106720	COG1842	Phage shock protein A
KW3_RS0106725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KW3_RS0106735	COG4168	peptide transport system, permease
KW3_RS0106750	COG4172	Belongs to the ABC transporter superfamily
KW3_RS0106765	COG1227	inorganic diphosphatase activity
KW3_RS0106785	COG0243	molybdopterin cofactor binding
KW3_RS0106790	COG3005	denitrification pathway
KW3_RS0106795	COG4459	periplasmic nitrate reductase
KW3_RS0106805	COG2116	formate transmembrane transporter activity
KW3_RS0106815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KW3_RS0106820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KW3_RS0106835	COG1607	acyl-coa hydrolase
KW3_RS0106840	COG2350	Protein conserved in bacteria
KW3_RS0106850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KW3_RS0106855	COG0583	DNA-binding transcription factor activity
KW3_RS0106870	COG0612	Peptidase, M16
KW3_RS0106875	COG5001	Diguanylate cyclase
KW3_RS0106880	COG1032	radical SAM domain protein
KW3_RS0106900	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KW3_RS0106910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KW3_RS0106915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KW3_RS0106920	COG0745	RESPONSE REGULATOR receiver
KW3_RS0106925	COG3381	protein complex oligomerization
KW3_RS0106930	COG1609	Transcriptional regulator
KW3_RS0106935	COG3070	regulator of competence-specific genes
KW3_RS0106955	COG0297	glycogen (starch) synthase activity
KW3_RS0106960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KW3_RS0106970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KW3_RS0107000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KW3_RS0107005	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KW3_RS0107030	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS0107035	COG1309	transcriptional regulator
KW3_RS0107055	COG0668	transmembrane transport
KW3_RS0107060	COG2995	paraquat-inducible protein a
KW3_RS0107065	COG3008	intermembrane lipid transfer
KW3_RS0107065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KW3_RS0107075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KW3_RS0107090	COG0582	viral genome integration into host DNA
KW3_RS0107100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KW3_RS0107120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KW3_RS0107140	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KW3_RS0107160	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
KW3_RS0107165	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
KW3_RS0107170	COG1737	Transcriptional regulator
KW3_RS0107175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KW3_RS0107180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KW3_RS0107185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KW3_RS0107190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KW3_RS0107200	COG1940	carbohydrate kinase activity
KW3_RS0107205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KW3_RS0107210	COG4409	exo-alpha-(2->6)-sialidase activity
KW3_RS0107220	COG2003	Belongs to the UPF0758 family
KW3_RS0107245	COG3941	tape measure
KW3_RS0107285	COG0488	(ABC) transporter
KW3_RS0107365	COG0415	Belongs to the DNA photolyase family
KW3_RS0107375	COG4628	conserved protein (DUF2132)
KW3_RS0107380	COG3284	Transcriptional regulator
KW3_RS0107385	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS0107395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KW3_RS0107400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KW3_RS0107405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KW3_RS0107415	COG2207	Transcriptional regulator
KW3_RS0107420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KW3_RS0107420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KW3_RS0107420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KW3_RS0107425	COG1482	cell wall glycoprotein biosynthetic process
KW3_RS0107435	COG5002	protein histidine kinase activity
KW3_RS0107435	COG0784	Response regulator, receiver
KW3_RS0107445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KW3_RS0107455	COG2885	chlorophyll binding
KW3_RS0107460	COG0823	Involved in the tonB-independent uptake of proteins
KW3_RS0107475	COG0811	peptide transport
KW3_RS0107480	COG0824	Thioesterase
KW3_RS0107485	COG3790	cyd operon protein YbgE
KW3_RS0107490	COG4890	Cyd operon protein YbgT
KW3_RS0107495	COG1294	oxidase, subunit
KW3_RS0107500	COG1271	oxidase subunit
KW3_RS0107510	COG0632	four-way junction helicase activity
KW3_RS0107515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KW3_RS0107520	COG0215	cysteine-tRNA ligase activity
KW3_RS0107525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KW3_RS0107530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KW3_RS0107535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KW3_RS0107540	COG3012	SEC-C Motif Domain Protein
KW3_RS0107545	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KW3_RS0107550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KW3_RS0107555	COG1199	ATP-dependent helicase activity
KW3_RS0107560	COG0730	response to heat
KW3_RS0107565	COG3923	Primosomal replication protein n
KW3_RS0107575	COG0840	transmembrane signaling receptor activity
KW3_RS0107580	COG0708	Exodeoxyribonuclease III
KW3_RS0107585	COG4160	amino acid transport
KW3_RS0107610	COG1882	Formate acetyltransferase
KW3_RS0107620	COG0840	transmembrane signaling receptor activity
KW3_RS0107625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KW3_RS0107635	COG3013	Belongs to the UPF0304 family
KW3_RS0107640	COG2766	serine protein kinase
KW3_RS0107645	COG2718	Belongs to the UPF0229 family
KW3_RS0107650	COG2719	SpoVR family
KW3_RS0107655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KW3_RS0107660	COG2835	tetraacyldisaccharide 4'-kinase activity
KW3_RS0107665	COG1663	tetraacyldisaccharide 4'-kinase activity
KW3_RS0107670	COG1132	(ABC) transporter
KW3_RS0107675	COG0658	competence protein
KW3_RS0107675	COG2333	competence protein COMEC
KW3_RS0107685	COG4591	ABC-type transport system involved in lipoprotein release permease component
KW3_RS0107690	COG1136	(ABC) transporter
KW3_RS0107695	COG4591	ABC-type transport system involved in lipoprotein release permease component
KW3_RS0107705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KW3_RS0107725	COG1252	NADH dehydrogenase
KW3_RS0107730	COG3150	esterase
KW3_RS0107755	COG0537	adenosine 5'-monophosphoramidase activity
KW3_RS0107770	COG2186	Transcriptional regulator
KW3_RS0107775	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KW3_RS0107780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KW3_RS0107785	COG1674	ftsk spoiiie
KW3_RS0107795	COG0686	Belongs to the AlaDH PNT family
KW3_RS0107805	COG0583	DNA-binding transcription factor activity
KW3_RS0107830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KW3_RS0107835	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
KW3_RS0107840	COG0776	regulation of translation
KW3_RS0107845	COG0539	negative regulation of cytoplasmic translation
KW3_RS0107850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KW3_RS0107855	COG1555	photosystem II stabilization
KW3_RS0107860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KW3_RS0107865	COG0776	regulation of translation
KW3_RS0107870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KW3_RS0107875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KW3_RS0107885	COG0544	peptidyl-prolyl cis-trans isomerase activity
KW3_RS0107895	COG4191	Histidine kinase
KW3_RS0107905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KW3_RS0107910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KW3_RS0107915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KW3_RS0107920	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KW3_RS0107935	COG3300	MHYT domain
KW3_RS0107935	COG5001	Diguanylate cyclase
KW3_RS0107945	COG4589	Belongs to the CDS family
KW3_RS0107980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KW3_RS0107990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KW3_RS0108010	COG0243	molybdopterin cofactor binding
KW3_RS0108015	COG3005	denitrification pathway
KW3_RS0108020	COG3325	Belongs to the glycosyl hydrolase 18 family
KW3_RS0108020	COG3469	chitinase activity
KW3_RS0108025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KW3_RS0108040	COG2951	lytic endotransglycosylase activity
KW3_RS0108045	COG3100	YcgL domain-containing protein
KW3_RS0108050	COG0850	regulation of cytokinetic process
KW3_RS0108055	COG2894	cell division
KW3_RS0108060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KW3_RS0108065	COG3015	lipoprotein NlpE involved in copper resistance
KW3_RS0108085	COG0477	Major facilitator Superfamily
KW3_RS0108095	COG0840	transmembrane signaling receptor activity
KW3_RS0108100	COG1396	sequence-specific DNA binding
KW3_RS0108105	COG3135	benzoate transporter
KW3_RS0108125	COG0596	Alpha beta hydrolase
KW3_RS0108130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KW3_RS0108135	COG1169	isochorismate synthase
KW3_RS0108140	COG0436	Aminotransferase
KW3_RS0108145	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KW3_RS0108150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KW3_RS0108170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KW3_RS0108175	COG0318	PFAM AMP-dependent synthetase and ligase
KW3_RS0108180	COG0596	Alpha beta hydrolase
KW3_RS0108195	COG1214	PFAM Peptidase M22, glycoprotease
KW3_RS0108200	COG1199	ATP-dependent helicase activity
KW3_RS0108210	COG0788	formyltetrahydrofolate deformylase activity
KW3_RS0108215	COG0446	pyridine nucleotide-disulphide oxidoreductase
KW3_RS0108215	COG1902	pentaerythritol trinitrate reductase activity
KW3_RS0108220	COG0616	signal peptide processing
KW3_RS0108225	COG0252	asparaginase activity
KW3_RS0108230	COG3139	Protein of unknown function (DUF1315)
KW3_RS0108240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KW3_RS0108245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KW3_RS0108250	COG0676	glucose-6-phosphate 1-epimerase activity
KW3_RS0108260	COG2226	methyltransferase
KW3_RS0108275	COG0835	chemotaxis
KW3_RS0108275	COG0784	Response regulator, receiver
KW3_RS0108280	COG1940	carbohydrate kinase activity
KW3_RS0108290	COG4667	esterase of the alpha-beta hydrolase superfamily
KW3_RS0108305	COG0733	neurotransmitter:sodium symporter activity
KW3_RS0108315	COG1263	PTS System
KW3_RS0108315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KW3_RS0108320	COG0084	hydrolase, TatD family'
KW3_RS0108330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KW3_RS0108335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KW3_RS0108340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KW3_RS0108345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KW3_RS0108350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KW3_RS0108355	COG1028	Short-chain dehydrogenase reductase Sdr
KW3_RS0108365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KW3_RS0108370	COG0416	fatty acid biosynthetic process
KW3_RS0108375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KW3_RS0108380	COG1399	metal-binding, possibly nucleic acid-binding protein
KW3_RS0108385	COG0424	maF-like protein
KW3_RS0108390	COG0564	pseudouridine synthase activity
KW3_RS0108400	COG1530	ribonuclease E activity
KW3_RS0108405	COG0659	secondary active sulfate transmembrane transporter activity
KW3_RS0108415	COG1454	alcohol dehydrogenase
KW3_RS0108415	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS0108420	COG2095	MarC family integral membrane protein
KW3_RS0108425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KW3_RS0108430	COG1757	Na H antiporter
KW3_RS0108440	COG3081	Nucleoid-associated protein
KW3_RS0108445	COG3082	Protein of unknown function (DUF1414)
KW3_RS0108450	COG3083	sulfuric ester hydrolase activity
KW3_RS0108465	COG0123	including yeast histone deacetylase and acetoin utilization protein
KW3_RS0108470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KW3_RS0108475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KW3_RS0108495	COG2853	Lipoprotein
KW3_RS0108505	COG4235	cytochrome complex assembly
KW3_RS0108505	COG3088	subunit of a heme lyase
KW3_RS0108510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KW3_RS0108515	COG1138	Cytochrome C-type biogenesis protein
KW3_RS0108520	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KW3_RS0108530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KW3_RS0108535	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KW3_RS0108540	COG4133	protoheme IX ABC transporter activity
KW3_RS0108550	COG0835	chemotaxis
KW3_RS0108560	COG1192	Involved in chromosome partitioning
KW3_RS0108565	COG2201	protein-glutamate methylesterase activity
KW3_RS0108570	COG2198	Histidine kinase
KW3_RS0108570	COG0643	Histidine kinase
KW3_RS0108570	COG0784	Response regulator, receiver
KW3_RS0108575	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KW3_RS0108605	COG2062	phosphohistidine phosphatase, SixA
KW3_RS0108610	COG1025	Belongs to the peptidase M16 family
KW3_RS0108620	COG0018	arginyl-trna synthetase
KW3_RS0108640	COG1918	ferrous iron import across plasma membrane
KW3_RS0108645	COG4977	sequence-specific DNA binding
KW3_RS0108650	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KW3_RS0108655	COG1121	(ABC) transporter
KW3_RS0108660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KW3_RS0108670	COG0045	succinate-CoA ligase (ADP-forming) activity
KW3_RS0108675	COG0508	dehydrogenase complex catalyzes the overall conversion of
KW3_RS0108680	COG0567	Dehydrogenase, E1 component
KW3_RS0108690	COG1053	succinate dehydrogenase
KW3_RS0108695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KW3_RS0108710	COG0372	Belongs to the citrate synthase family
KW3_RS0108715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KW3_RS0108725	COG0033	Phosphoglucomutase
KW3_RS0108730	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KW3_RS0108735	COG0596	Alpha beta hydrolase
KW3_RS0108750	COG1346	cytolysis
KW3_RS0108760	COG0583	DNA-binding transcription factor activity
KW3_RS0108770	COG0735	belongs to the Fur family
KW3_RS0108775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KW3_RS0108780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KW3_RS0108785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KW3_RS0108795	COG0431	NADPH-dependent FMN reductase
KW3_RS0108805	COG3101	peptidyl-lysine hydroxylation
KW3_RS0108810	COG2860	membrane
KW3_RS0108815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KW3_RS0108820	COG2890	protein-(glutamine-N5) methyltransferase activity
KW3_RS0108825	COG2840	Smr protein MutS2
KW3_RS0108835	COG1684	flagellar biosynthetic protein fliR
KW3_RS0108840	COG1987	bacterial-type flagellum assembly
KW3_RS0108865	COG1580	Controls the rotational direction of flagella during chemotaxis
KW3_RS0108885	COG1317	bacterial-type flagellum organization
KW3_RS0108890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KW3_RS0108900	COG1677	Flagellar hook-basal body complex protein FliE
KW3_RS0108920	COG1516	flagellar protein fliS
KW3_RS0108930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KW3_RS0108935	COG1334	flagellar protein FlaG
KW3_RS0108940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KW3_RS0108945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KW3_RS0108950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KW3_RS0108955	COG2837	iron assimilation
KW3_RS0108975	COG1393	Belongs to the ArsC family
KW3_RS0108985	COG1876	peptidase activity
KW3_RS0108995	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KW3_RS0109010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KW3_RS0109030	COG4783	chaperone-mediated protein folding
KW3_RS0109035	COG1393	Belongs to the ArsC family
KW3_RS0109055	COG2233	PERMEase
KW3_RS0109060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KW3_RS0109065	COG0737	Belongs to the 5'-nucleotidase family
KW3_RS0109070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KW3_RS0109075	COG2912	Transglutaminase-like superfamily
KW3_RS0109085	COG2890	protein-(glutamine-N5) methyltransferase activity
KW3_RS0109090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KW3_RS0109095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KW3_RS0109100	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KW3_RS0109105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KW3_RS0109110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KW3_RS0109115	COG0193	aminoacyl-tRNA hydrolase activity
KW3_RS0109120	COG0012	GTP binding
KW3_RS0109150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KW3_RS0109155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KW3_RS0109170	COG3951	Flagellar rod assembly protein muramidase FlgJ
KW3_RS0109170	COG1705	Flagellar rod assembly protein muramidase FlgJ
KW3_RS0109175	COG1706	bacterial-type flagellum-dependent cell motility
KW3_RS0109180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KW3_RS0109190	COG4787	bacterial-type flagellum-dependent cell motility
KW3_RS0109195	COG1749	Flagellar hook protein flgE
KW3_RS0109210	COG1815	bacterial-type flagellum-dependent cell motility
KW3_RS0109215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KW3_RS0109220	COG0835	chemotaxis
KW3_RS0109220	COG0784	Response regulator, receiver
KW3_RS0109255	COG3433	isochorismatase activity
KW3_RS0109255	COG2226	methyltransferase
KW3_RS0109255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KW3_RS0109260	COG2375	cellular response to nickel ion
KW3_RS0109265	COG4774	siderophore transport
KW3_RS0109265	COG1629	transport
KW3_RS0109280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KW3_RS0109285	COG2608	mercury ion transmembrane transporter activity
KW3_RS0109285	COG2217	Heavy metal translocating P-type atpase
KW3_RS0109300	COG3735	TraB family
KW3_RS0109315	COG2840	Smr protein MutS2
KW3_RS0109320	COG1187	pseudouridine synthase activity
KW3_RS0109330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KW3_RS0109335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KW3_RS0109340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KW3_RS0109345	COG0121	glutamine amidotransferase
KW3_RS0109350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KW3_RS0109355	COG1960	acyl-CoA dehydrogenase activity
KW3_RS0109370	COG0328	RNA-DNA hybrid ribonuclease activity
KW3_RS0109375	COG2226	methyltransferase
KW3_RS0109380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KW3_RS0109385	COG1388	LysM domain
KW3_RS0109385	COG0741	lytic transglycosylase activity
KW3_RS0109390	COG3021	interspecies interaction between organisms
KW3_RS0109395	COG0347	Belongs to the P(II) protein family
KW3_RS0109400	COG3479	Phenolic acid decarboxylase
KW3_RS0109410	COG0037	tRNA processing
KW3_RS0109415	COG0825	malonyl-CoA metabolic process
KW3_RS0109425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KW3_RS0109430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KW3_RS0109435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KW3_RS0109440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KW3_RS0109445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KW3_RS0109450	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
KW3_RS0109460	COG0750	zinc metalloprotease
KW3_RS0109465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KW3_RS0109470	COG0575	Belongs to the CDS family
KW3_RS0109475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KW3_RS0109480	COG0233	cytoplasmic translational termination
KW3_RS0109485	COG0528	UMP kinase activity
KW3_RS0109490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KW3_RS0109495	COG0052	Belongs to the universal ribosomal protein uS2 family
KW3_RS0109500	COG0024	Methionine aminopeptidase
KW3_RS0109505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KW3_RS0109515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KW3_RS0109520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KW3_RS0109525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KW3_RS0109530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KW3_RS0109545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KW3_RS0109545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KW3_RS0109550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KW3_RS0109555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KW3_RS0109560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KW3_RS0109570	COG1073	alpha beta
KW3_RS0109575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KW3_RS0109580	COG2252	PERMEase
KW3_RS0109585	COG2195	Cleaves the N-terminal amino acid of tripeptides
KW3_RS0109590	COG4067	protein conserved in archaea
KW3_RS0109590	COG0189	ligase activity
KW3_RS0109595	COG0189	ligase activity
KW3_RS0109605	COG0733	neurotransmitter:sodium symporter activity
KW3_RS0109610	COG3706	GGDEF domain
KW3_RS0109615	COG3328	transposase activity
KW3_RS0109645	COG1477	protein flavinylation
KW3_RS0109650	COG2871	sodium ion transport
KW3_RS0109655	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KW3_RS0109660	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KW3_RS0109665	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KW3_RS0109670	COG1805	sodium ion transport
KW3_RS0109675	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KW3_RS0109680	COG0271	Belongs to the BolA IbaG family
KW3_RS0109685	COG2813	Specifically methylates the guanine in position
KW3_RS0109695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KW3_RS0109700	COG2211	Major facilitator Superfamily
KW3_RS0109710	COG1595	DNA-templated transcription, initiation
KW3_RS0109720	COG3248	Nucleoside-binding outer membrane protein
KW3_RS0109725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KW3_RS0109730	COG0693	protein deglycase activity
KW3_RS0109735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KW3_RS0109740	COG2166	iron-sulfur cluster assembly
KW3_RS0109745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KW3_RS0109750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KW3_RS0109760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KW3_RS0109760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KW3_RS0109775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KW3_RS0109780	COG1074	ATP-dependent DNA helicase activity
KW3_RS0109785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KW3_RS0109800	COG3141	response to X-ray
KW3_RS0109805	COG2171	N-acyltransferase activity
KW3_RS0109815	COG0456	acetyltransferase
KW3_RS0109825	COG0569	domain protein
KW3_RS0109825	COG0189	ligase activity
KW3_RS0109840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KW3_RS0109845	COG1609	Transcriptional regulator
KW3_RS0109850	COG3250	beta-galactosidase activity
KW3_RS0109865	COG1022	Amp-dependent synthetase and ligase
KW3_RS0109870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KW3_RS0109875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KW3_RS0109885	COG0560	Phosphoserine phosphatase
KW3_RS0109895	COG0813	purine-nucleoside phosphorylase activity
KW3_RS0109900	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KW3_RS0109905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KW3_RS0109910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KW3_RS0109915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KW3_RS0109920	COG0084	hydrolase, TatD family'
KW3_RS0109925	COG3022	response to hydroperoxide
KW3_RS0109930	COG1115	amino acid carrier protein
KW3_RS0109945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KW3_RS0109950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KW3_RS0109955	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
KW3_RS0109960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KW3_RS0109980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KW3_RS0109990	COG0745	RESPONSE REGULATOR receiver
KW3_RS0109995	COG2198	Histidine kinase
KW3_RS0109995	COG0784	Response regulator, receiver
KW3_RS0109995	COG5002	protein histidine kinase activity
KW3_RS0110000	COG3706	GGDEF domain
KW3_RS0110000	COG2203	Gaf domain
KW3_RS0110000	COG4251	negative regulation of phosphorylation
KW3_RS0110000	COG5001	Diguanylate cyclase
KW3_RS0110005	COG1242	4 iron, 4 sulfur cluster binding
KW3_RS0110010	COG0067	glutamate synthase
KW3_RS0110010	COG0070	glutamate synthase
KW3_RS0110010	COG0069	glutamate synthase activity
KW3_RS0110020	COG0067	glutamate synthase
KW3_RS0110020	COG0069	glutamate synthase activity
KW3_RS0110020	COG0070	glutamate synthase
KW3_RS0110025	COG0493	'glutamate synthase
KW3_RS0110035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KW3_RS0110045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KW3_RS0110050	COG2860	membrane
KW3_RS0110055	COG0583	DNA-binding transcription factor activity
KW3_RS0110060	COG0730	response to heat
KW3_RS0110070	COG4172	Belongs to the ABC transporter superfamily
KW3_RS0110090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KW3_RS0110095	COG0505	Belongs to the CarA family
KW3_RS0110105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KW3_RS0110110	COG0494	nUDIX hydrolase
KW3_RS0110115	COG0653	protein targeting
KW3_RS0110125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KW3_RS0110130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KW3_RS0110135	COG0849	cell division
KW3_RS0110140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KW3_RS0110145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KW3_RS0110155	COG0772	Belongs to the SEDS family
KW3_RS0110160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KW3_RS0110170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KW3_RS0110175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KW3_RS0110180	COG0768	penicillin binding
KW3_RS0110185	COG3116	cell division
KW3_RS0110195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KW3_RS0110200	COG0508	dehydrogenase complex catalyzes the overall conversion of
KW3_RS0110205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KW3_RS0110210	COG2186	Transcriptional regulator
KW3_RS0110215	COG0737	Belongs to the 5'-nucleotidase family
KW3_RS0110220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KW3_RS0110225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KW3_RS0110230	COG4974	Belongs to the 'phage' integrase family
KW3_RS0110235	COG0716	FMN binding
KW3_RS0110255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KW3_RS0110260	COG1459	type II secretion system
KW3_RS0110270	COG0237	dephospho-CoA kinase activity
KW3_RS0110275	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
KW3_RS0110290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KW3_RS0110295	COG0187	DNA topoisomerase II activity
KW3_RS0110300	COG3150	esterase
KW3_RS0110310	COG3151	Protein conserved in bacteria
KW3_RS0110315	COG0494	nUDIX hydrolase
KW3_RS0110320	COG1538	Outer membrane efflux protein
KW3_RS0110330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KW3_RS0110335	COG0840	transmembrane signaling receptor activity
KW3_RS0110345	COG3025	triphosphatase activity
KW3_RS0110350	COG1392	Phosphate transport regulator
KW3_RS0110355	COG0306	phosphate transporter
KW3_RS0110360	COG4991	sh3 domain protein
KW3_RS0110370	COG3267	Type II secretory pathway component ExeA
KW3_RS0110370	COG3409	Peptidoglycan-binding domain 1 protein
KW3_RS0110380	COG0148	phosphopyruvate hydratase activity
KW3_RS0110385	COG0504	CTP synthase activity
KW3_RS0110395	COG3956	TIGRFAM MazG family protein
KW3_RS0110400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KW3_RS0110415	COG5001	Diguanylate cyclase
KW3_RS0110435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KW3_RS0110440	COG1381	Involved in DNA repair and RecF pathway recombination
KW3_RS0110445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KW3_RS0110460	COG0481	GTPase activity
KW3_RS0110465	COG3086	response to oxidative stress
KW3_RS0110480	COG1595	DNA-templated transcription, initiation
KW3_RS0110485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KW3_RS0110495	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KW3_RS0110510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KW3_RS0110515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KW3_RS0110520	COG3079	Belongs to the UPF0149 family
KW3_RS0110525	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KW3_RS0110530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KW3_RS0110535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KW3_RS0110540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KW3_RS0110545	COG0440	acetolactate synthase activity
KW3_RS0110550	COG0028	Belongs to the TPP enzyme family
KW3_RS0110555	COG1022	Amp-dependent synthetase and ligase
KW3_RS0110560	COG0583	DNA-binding transcription factor activity
KW3_RS0110585	COG0473	3-isopropylmalate dehydrogenase activity
KW3_RS0110590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KW3_RS0110595	COG0066	3-isopropylmalate dehydratase activity
KW3_RS0110640	COG3437	response regulator, receiver
KW3_RS0110655	COG0795	lipopolysaccharide-transporting ATPase activity
KW3_RS0110660	COG0795	lipopolysaccharide-transporting ATPase activity
KW3_RS0110665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KW3_RS0110670	COG2927	DNA polymerase III (CHI subunit)
KW3_RS0110675	COG0525	valine-tRNA ligase activity
KW3_RS0110680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KW3_RS0110685	COG0564	pseudouridine synthase activity
KW3_RS0110700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KW3_RS0110715	COG0540	Belongs to the ATCase OTCase family
KW3_RS0110725	COG0251	oxidation-reduction process
KW3_RS0110735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KW3_RS0110740	COG5007	Belongs to the BolA IbaG family
KW3_RS0110750	COG2854	intermembrane phospholipid transfer
KW3_RS0110755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KW3_RS0110760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KW3_RS0110765	COG1127	ABC transporter
KW3_RS0110775	COG0517	IMP dehydrogenase activity
KW3_RS0110775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KW3_RS0110790	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KW3_RS0110795	COG1137	ATPase activity
KW3_RS0110805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KW3_RS0110810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KW3_RS0110815	COG1660	Displays ATPase and GTPase activities
KW3_RS0110820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KW3_RS0110825	COG2239	Acts as a magnesium transporter
KW3_RS0110830	COG0312	modulator of DNA gyrase
KW3_RS0110835	COG3028	Belongs to the UPF0307 family
KW3_RS0110840	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KW3_RS0110845	COG1178	ABC-type Fe3 transport system permease component
KW3_RS0110855	COG0163	prenyltransferase activity
KW3_RS0110860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KW3_RS0110870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KW3_RS0110875	COG2105	PFAM AIG2 family protein
KW3_RS0110885	COG0729	surface antigen
KW3_RS0110890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KW3_RS0110895	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KW3_RS0110910	COG1136	(ABC) transporter
KW3_RS0110930	COG0529	Catalyzes the synthesis of activated sulfate
KW3_RS0110945	COG1648	precorrin-2 dehydrogenase activity
KW3_RS0110945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KW3_RS0110950	COG0737	Belongs to the 5'-nucleotidase family
KW3_RS0110960	COG0513	Belongs to the DEAD box helicase family
KW3_RS0110965	COG2153	protein acetylation
KW3_RS0110970	COG0697	spore germination
KW3_RS0110975	COG3061	Opacity-associated protein A
KW3_RS0110975	COG3266	domain, Protein
KW3_RS0110980	COG0545	Peptidyl-prolyl cis-trans isomerase
KW3_RS0110990	COG0203	ribosomal protein L17
KW3_RS0110995	COG0202	RNA polymerase activity
KW3_RS0111000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KW3_RS0111005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KW3_RS0111010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KW3_RS0111015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KW3_RS0111020	COG0201	protein transport
KW3_RS0111030	COG1841	ribosomal large subunit assembly
KW3_RS0111035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KW3_RS0111040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KW3_RS0111050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KW3_RS0111055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KW3_RS0111060	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KW3_RS0111065	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KW3_RS0111070	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KW3_RS0111075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KW3_RS0111080	COG0255	Belongs to the universal ribosomal protein uL29 family
KW3_RS0111085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KW3_RS0111090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KW3_RS0111095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KW3_RS0111100	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KW3_RS0111105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KW3_RS0111110	COG0089	rRNA binding
KW3_RS0111115	COG0088	Forms part of the polypeptide exit tunnel
KW3_RS0111120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KW3_RS0111125	COG0051	transcription antitermination factor activity, RNA binding
KW3_RS0111130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KW3_RS0111135	COG0557	exoribonuclease II activity
KW3_RS0111140	COG3083	sulfuric ester hydrolase activity
KW3_RS0111145	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KW3_RS0111160	COG1047	Peptidyl-prolyl cis-trans
KW3_RS0111175	COG2249	NAD(P)H dehydrogenase (quinone) activity
KW3_RS0111180	COG0488	(ABC) transporter
KW3_RS0111190	COG0429	hydrolase of the alpha beta-hydrolase fold
KW3_RS0111200	COG3954	Phosphoribulokinase
KW3_RS0111215	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS0111225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KW3_RS0111235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KW3_RS0111250	COG0180	Tryptophanyl-tRNA synthetase
KW3_RS0111255	COG0546	phosphoglycolate phosphatase activity
KW3_RS0111260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KW3_RS0111265	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KW3_RS0111275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KW3_RS0111280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KW3_RS0111310	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KW3_RS0111320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KW3_RS0111320	COG0678	peroxiredoxin activity
KW3_RS0111325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KW3_RS0111335	COG0165	Argininosuccinate lyase
KW3_RS0111340	COG0137	argininosuccinate synthase activity
KW3_RS0111345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KW3_RS0111350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KW3_RS0111355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KW3_RS0111360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KW3_RS0111370	COG1045	serine acetyltransferase
KW3_RS0111375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KW3_RS0111380	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KW3_RS0111385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KW3_RS0111390	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KW3_RS0111395	COG1053	succinate dehydrogenase
KW3_RS0111400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KW3_RS0111405	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KW3_RS0111415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KW3_RS0111420	COG1509	lysine 2,3-aminomutase activity
KW3_RS0111430	COG0459	protein refolding
KW3_RS0111435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KW3_RS0111460	COG0149	triose-phosphate isomerase activity
KW3_RS0111465	COG0534	Mate efflux family protein
KW3_RS0111470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KW3_RS0111475	COG1575	Belongs to the MenA family. Type 1 subfamily
KW3_RS0111480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KW3_RS0111485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KW3_RS0111490	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KW3_RS0111495	COG1609	Transcriptional regulator
KW3_RS0111500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KW3_RS0111505	COG0254	rRNA binding
KW3_RS0111510	COG0281	malic enzyme
KW3_RS0111515	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
KW3_RS0111520	COG0626	cystathionine gamma-synthase activity
KW3_RS0111525	COG0527	aspartate kinase activity
KW3_RS0111525	COG0460	homoserine dehydrogenase
KW3_RS0111535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KW3_RS0111540	COG3074	FtsZ-dependent cytokinesis
KW3_RS0111545	COG1494	fructose-1,6-bisphosphatase
KW3_RS0111550	COG0205	6-phosphofructokinase activity
KW3_RS0111555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KW3_RS0111565	COG0745	RESPONSE REGULATOR receiver
KW3_RS0111570	COG2205	protein histidine kinase activity
KW3_RS0111580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KW3_RS0111585	COG3030	protein affecting phage T7 exclusion by the F plasmid
KW3_RS0111590	COG3706	GGDEF domain
KW3_RS0111595	COG1027	Aspartate ammonia-lyase
KW3_RS0111600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KW3_RS0111615	COG4232	protein-disulfide reductase activity
KW3_RS0111635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KW3_RS0111640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KW3_RS0111645	COG0194	GDP metabolic process
KW3_RS0111650	COG1758	RNA polymerase activity
KW3_RS0111655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KW3_RS0111660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KW3_RS0111665	COG2233	PERMEase
KW3_RS0111680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KW3_RS0111685	COG2183	response to ionizing radiation
KW3_RS0111695	COG0596	Alpha beta hydrolase
KW3_RS0111700	COG1040	competence protein
KW3_RS0111710	COG0494	nUDIX hydrolase
KW3_RS0111715	COG1218	3'(2'),5'-bisphosphate nucleotidase
KW3_RS0111725	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KW3_RS0111730	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KW3_RS0111735	COG3156	type II secretion system protein K
KW3_RS0111740	COG4795	General secretion pathway protein
KW3_RS0111745	COG2165	general secretion pathway protein
KW3_RS0111750	COG2165	general secretion pathway protein
KW3_RS0111755	COG2165	general secretion pathway protein
KW3_RS0111760	COG1459	type II secretion system
KW3_RS0111765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KW3_RS0111775	COG3031	protein transport across the cell outer membrane
KW3_RS0111780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KW3_RS0111785	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KW3_RS0111790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KW3_RS0111800	COG0456	acetyltransferase
KW3_RS0111805	COG1490	D-aminoacyl-tRNA deacylase activity
KW3_RS0111810	COG1295	ribonuclease BN
KW3_RS0111820	COG1217	gtp-binding protein TYPA
KW3_RS0111830	COG0174	glutamine synthetase
KW3_RS0111845	COG3852	Histidine kinase
KW3_RS0111855	COG3300	MHYT domain
KW3_RS0111855	COG5001	Diguanylate cyclase
KW3_RS0111860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KW3_RS0111895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KW3_RS0111900	COG1404	Belongs to the peptidase S8 family
KW3_RS0111905	COG4206	TonB-dependent receptor
KW3_RS0111910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KW3_RS0111925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KW3_RS0111930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KW3_RS0111935	COG2177	Part of the ABC transporter FtsEX involved in
KW3_RS0111940	COG2884	Cell division ATP-binding protein ftsE
KW3_RS0111945	COG0552	protein localization to endoplasmic reticulum
KW3_RS0111950	COG0742	ribosomal rna small subunit methyltransferase
KW3_RS0111985	COG0783	Belongs to the Dps family
KW3_RS0111990	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KW3_RS0111995	COG1280	lysine exporter protein (LysE YggA)
KW3_RS0112000	COG2267	carboxylic ester hydrolase activity
KW3_RS0112005	COG0561	phosphatase activity
KW3_RS0112020	COG3287	FIST C domain
KW3_RS0112020	COG2199	diguanylate cyclase activity
KW3_RS0112020	COG2200	EAL domain
KW3_RS0112025	COG1011	Hydrolase
KW3_RS0112030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KW3_RS0112040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KW3_RS0112045	COG0019	diaminopimelate decarboxylase activity
KW3_RS0112055	COG1965	Belongs to the frataxin family
KW3_RS0112070	COG0181	hydroxymethylbilane synthase activity
KW3_RS0112075	COG1587	Uroporphyrinogen-III synthase
KW3_RS0112080	COG2959	enzyme of heme biosynthesis
KW3_RS0112085	COG3071	HemY protein
KW3_RS0112100	COG3078	GTPase activator activity
KW3_RS0112120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KW3_RS0112120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KW3_RS0112135	COG0084	hydrolase, TatD family'
KW3_RS0112140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KW3_RS0112155	COG0840	transmembrane signaling receptor activity
KW3_RS0112160	COG1580	Controls the rotational direction of flagella during chemotaxis
KW3_RS0112165	COG3161	chorismate lyase activity
KW3_RS0112170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KW3_RS0112180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KW3_RS0112190	COG0534	Mate efflux family protein
KW3_RS0112195	COG1858	cytochrome C peroxidase
KW3_RS0112200	COG0805	protein transport
KW3_RS0112205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KW3_RS0112210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KW3_RS0112225	COG2226	methyltransferase
KW3_RS0112230	COG1322	Protein conserved in bacteria
KW3_RS0112240	COG2081	HI0933 family
KW3_RS0112250	COG1528	Iron-storage protein
KW3_RS0112255	COG0589	response to stress
KW3_RS0112275	COG5002	protein histidine kinase activity
KW3_RS0112275	COG5001	Diguanylate cyclase
KW3_RS0112280	COG1522	sequence-specific DNA binding
KW3_RS0112300	COG0006	proline dipeptidase activity
KW3_RS0112300	COG0006	proline dipeptidase activity
KW3_RS0112305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KW3_RS0112310	COG2022	thiamine diphosphate biosynthetic process
KW3_RS0112315	COG2104	thiamine diphosphate biosynthetic process
KW3_RS0112320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KW3_RS0112330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KW3_RS0112335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KW3_RS0112375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KW3_RS0112385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KW3_RS0112390	COG0408	coproporphyrinogen oxidase activity
KW3_RS0112395	COG0009	L-threonylcarbamoyladenylate synthase
KW3_RS0112400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KW3_RS0112405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KW3_RS0112410	COG0551	DNA topoisomerase type I activity
KW3_RS0112415	COG2922	Belongs to the Smg family
KW3_RS0112420	COG0758	DNA mediated transformation
KW3_RS0112425	COG1652	LysM domain
KW3_RS0112430	COG0242	peptide deformylase activity
KW3_RS0112435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KW3_RS0112440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KW3_RS0112440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KW3_RS0112445	COG0569	domain protein
KW3_RS0112450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KW3_RS0112460	COG1272	protein, Hemolysin III
KW3_RS0112465	COG4326	sporulation control protein
KW3_RS0112475	COG3084	Protein conserved in bacteria
KW3_RS0112485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KW3_RS0112490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KW3_RS0112495	COG0204	Acyl-transferase
KW3_RS0112500	COG0606	chelatase, subunit chli
KW3_RS0112515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KW3_RS0112520	COG0129	dihydroxy-acid dehydratase activity
KW3_RS0112530	COG0604	alcohol dehydrogenase
KW3_RS0112540	COG0425	Belongs to the sulfur carrier protein TusA family
KW3_RS0112550	COG2119	membrane
KW3_RS0112555	COG0752	glycyl-tRNA synthetase alpha subunit
KW3_RS0112560	COG0751	glycine-tRNA ligase activity
KW3_RS0112565	COG3977	Valine--pyruvate aminotransferase
KW3_RS0112570	COG0071	Belongs to the small heat shock protein (HSP20) family
KW3_RS0112585	COG0187	DNA topoisomerase II activity
KW3_RS0112590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KW3_RS0112595	COG0592	DNA-directed DNA polymerase activity
KW3_RS0112600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KW3_RS0112615	COG1126	abc transporter atp-binding protein
KW3_RS0112620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KW3_RS0112625	COG0594	ribonuclease P activity
KW3_RS0112630	COG0706	membrane insertase activity
KW3_RS0112635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KW3_RS0112640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KW3_RS0112645	COG0445	tRNA wobble uridine modification
KW3_RS0112655	COG1192	Involved in chromosome partitioning
KW3_RS0112660	COG1475	DNA binding
KW3_RS0112665	COG3312	ion transport
KW3_RS0112670	COG0356	it plays a direct role in the translocation of protons across the membrane
KW3_RS0112680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KW3_RS0112685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KW3_RS0112690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KW3_RS0112695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KW3_RS0112700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KW3_RS0112705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KW3_RS0112710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KW3_RS0112715	COG2814	Major facilitator Superfamily
KW3_RS0112720	COG0583	DNA-binding transcription factor activity
KW3_RS0112725	COG0183	Belongs to the thiolase family
KW3_RS0112735	COG1739	Uncharacterized protein family UPF0029
KW3_RS0112740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KW3_RS0112745	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KW3_RS0112790	COG0583	DNA-binding transcription factor activity
KW3_RS0112795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KW3_RS0112800	COG2960	long-chain fatty acid transporting porin activity
KW3_RS0112805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KW3_RS0112810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KW3_RS0112815	COG1309	transcriptional regulator
KW3_RS0112865	COG0747	negative chemotaxis
KW3_RS0112870	COG0601	transmembrane transport
KW3_RS0112875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KW3_RS0112885	COG2131	deaminase
KW3_RS0112910	COG3621	Patatin-like phospholipase
KW3_RS0112950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KW3_RS0112955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KW3_RS0112965	COG0210	DNA helicase
KW3_RS0112970	COG1280	lysine exporter protein (LysE YggA)
KW3_RS0112985	COG2962	Rard protein
KW3_RS0112990	COG0514	ATP-dependent DNA helicase (RecQ)
KW3_RS0113005	COG1132	(ABC) transporter
KW3_RS0113010	COG4774	siderophore transport
KW3_RS0113015	COG1120	ATPase activity
KW3_RS0113035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KW3_RS0113040	COG1263	PTS System
KW3_RS0113040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KW3_RS0113045	COG2862	Uncharacterized protein family, UPF0114
KW3_RS0113050	COG1561	YicC-like family, N-terminal region
KW3_RS0113055	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KW3_RS0113060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KW3_RS0113065	COG1560	Kdo2-lipid A biosynthetic process
KW3_RS0113070	COG1560	Kdo2-lipid A biosynthetic process
KW3_RS0113075	COG1309	transcriptional regulator
KW3_RS0113080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KW3_RS0113090	COG2003	Belongs to the UPF0758 family
KW3_RS0113095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KW3_RS0113100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KW3_RS0113110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KW3_RS0113115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KW3_RS0113120	COG0859	PFAM glycosyl transferase family 9
KW3_RS0113125	COG0463	Glycosyl transferase, family 2
KW3_RS0113130	COG0859	PFAM glycosyl transferase family 9
KW3_RS0113135	COG3642	lipopolysaccharide core region biosynthetic process
KW3_RS0113165	COG1519	Transferase
KW3_RS0113200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KW3_RS0113205	COG0662	Cupin 2, conserved barrel domain protein
KW3_RS0113205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KW3_RS0113210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KW3_RS0113215	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KW3_RS0113245	COG0318	PFAM AMP-dependent synthetase and ligase
KW3_RS0113250	COG1012	belongs to the aldehyde dehydrogenase family
KW3_RS0113250	COG1454	alcohol dehydrogenase
KW3_RS0113265	COG5433	transposase activity
KW3_RS0113295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KW3_RS0113300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KW3_RS0113305	COG0668	transmembrane transport
KW3_RS0113310	COG1573	uracil-dna glycosylase
KW3_RS0113320	COG3068	Protein conserved in bacteria
KW3_RS0113330	COG1940	carbohydrate kinase activity
KW3_RS0113335	COG1253	flavin adenine dinucleotide binding
KW3_RS0113340	COG0776	regulation of translation
KW3_RS0113350	COG0151	Belongs to the GarS family
KW3_RS0113360	COG0789	Transcriptional regulator
KW3_RS0113365	COG3710	Transcriptional regulator
KW3_RS0113370	COG0531	amino acid
KW3_RS0113375	COG1982	Orn Lys Arg decarboxylase major
KW3_RS0113380	COG0840	transmembrane signaling receptor activity
KW3_RS0113400	COG0800	Aldolase
KW3_RS0113410	COG3265	gluconokinase activity
KW3_RS0113415	COG0129	dihydroxy-acid dehydratase activity
KW3_RS0113420	COG1609	Transcriptional regulator
KW3_RS0113425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KW3_RS0113430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KW3_RS0113435	COG2264	protein methyltransferase activity
KW3_RS0113440	COG0439	Biotin carboxylase
KW3_RS0113445	COG0511	ligase activity, forming carbon-carbon bonds
KW3_RS0113450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KW3_RS0113455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KW3_RS0113470	COG2814	Major facilitator Superfamily
KW3_RS0113475	COG0784	Response regulator, receiver
KW3_RS0113475	COG2205	protein histidine kinase activity
KW3_RS0113480	COG0248	Ppx GppA phosphatase
KW3_RS0113485	COG0513	Belongs to the DEAD box helicase family
KW3_RS0113490	COG3118	belongs to the thioredoxin family
KW3_RS0113505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KW3_RS0113550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KW3_RS0113560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KW3_RS0113570	COG1072	(Pantothenic acid kinase))
KW3_RS0113595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KW3_RS0113600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KW3_RS0113605	COG0250	Participates in transcription elongation, termination and antitermination
KW3_RS0113610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KW3_RS0113620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KW3_RS0113625	COG0222	ribosome binding
KW3_RS0113630	COG0085	RNA polymerase activity
KW3_RS0113635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KW3_RS0113640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
KW3_RS0113645	COG2816	NAD+ diphosphatase activity
KW3_RS0113650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KW3_RS0113665	COG4942	peptidase
KW3_RS0113670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KW3_RS0113680	COG0471	metal ion transport
KW3_RS0113685	COG0688	phosphatidylethanolamine metabolic process
KW3_RS0113690	COG1162	GTPase activity
KW3_RS0113695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KW3_RS0113745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KW3_RS0113750	COG0802	atpase or kinase
KW3_RS0113760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KW3_RS0113765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KW3_RS0113770	COG1923	regulation of RNA biosynthetic process
KW3_RS0113775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KW3_RS0113780	COG0330	HflC and HflK could
KW3_RS0113785	COG0330	HflC and HflK could
KW3_RS0113790	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
KW3_RS0113795	COG2900	Belongs to the SlyX family
KW3_RS0113805	COG0545	Peptidyl-prolyl cis-trans isomerase
KW3_RS0113810	COG2964	Protein conserved in bacteria
KW3_RS0113815	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KW3_RS0113820	COG2923	Belongs to the DsrF TusC family
KW3_RS0113835	COG0049	tRNA binding
KW3_RS0113840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KW3_RS0113845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KW3_RS0113860	COG0360	Binds together with S18 to 16S ribosomal RNA
KW3_RS0113865	COG2965	DNA replication, synthesis of RNA primer
KW3_RS0113870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KW3_RS0113875	COG0359	binds to the 23S rRNA
KW3_RS0113890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KW3_RS0113895	COG0432	Pfam Uncharacterised protein family UPF0047
KW3_RS0113920	COG0735	belongs to the Fur family
KW3_RS0113925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KW3_RS0113945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KW3_RS0113955	COG0175	sulfate reduction
KW3_RS0115030	COG0784	Response regulator, receiver
KW3_RS0115030	COG2205	protein histidine kinase activity
KW3_RS0115135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KW3_RS0115690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KW3_RS0116025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KW3_RS0116045	COG0573	inorganic phosphate transmembrane transporter activity
KW3_RS0116115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KW3_RS0116420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KW3_RS0116890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KW3_RS0117125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KW3_RS0117280	COG0101	tRNA pseudouridine synthase activity
KW3_RS0117630	COG2204	response regulator
KW3_RS0117650	COG4166	transmembrane transport
KW3_RS0117655	COG4166	transmembrane transport
KW3_RS0117695	COG0280	phosphate acetyltransferase
KW3_RS0117695	COG0857	belongs to the CobB CobQ family
KW3_RS0117745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KW3_RS0117830	COG0131	Imidazoleglycerol-phosphate dehydratase
KW3_RS0117830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KW3_RS0117885	COG3273	potassium ion transport
KW3_RS0117885	COG2985	domain, Protein
KW3_RS0118195	COG0277	FAD linked oxidase domain protein
KW3_RS0118195	COG0247	lactate metabolic process
KW3_RS0118245	COG0010	Belongs to the arginase family
KW3_RS0118365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KW3_RS0118400	COG0776	regulation of translation
KW3_RS0118550	COG0840	transmembrane signaling receptor activity
KW3_RS0118640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner