locus-tag	class	description
K6J81_RS00090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6J81_RS00105	COG3852	Histidine kinase
K6J81_RS00115	COG0174	glutamine synthetase
K6J81_RS00135	COG1295	ribonuclease BN
K6J81_RS00140	COG1490	D-aminoacyl-tRNA deacylase activity
K6J81_RS00145	COG0456	acetyltransferase
K6J81_RS00165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6J81_RS00170	COG3031	protein transport across the cell outer membrane
K6J81_RS00195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6J81_RS00220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K6J81_RS00235	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6J81_RS00240	COG1401	restriction endodeoxyribonuclease activity
K6J81_RS00285	COG4584	PFAM Integrase catalytic
K6J81_RS00300	COG1484	DNA-dependent DNA replication
K6J81_RS00350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6J81_RS00365	COG0681	Belongs to the peptidase S26 family
K6J81_RS00405	COG0629	single-stranded DNA binding
K6J81_RS00425	COG0714	Associated with various cellular activities
K6J81_RS00450	COG2003	Belongs to the UPF0758 family
K6J81_RS00565	COG0513	Belongs to the DEAD box helicase family
K6J81_RS00585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6J81_RS00590	COG2204	response regulator
K6J81_RS00600	COG0667	Aldo Keto reductase
K6J81_RS00610	COG0494	nUDIX hydrolase
K6J81_RS00615	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
K6J81_RS00620	COG0730	response to heat
K6J81_RS00625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6J81_RS00635	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6J81_RS00640	COG0583	DNA-binding transcription factor activity
K6J81_RS00645	COG0640	Transcriptional regulator
K6J81_RS00650	COG0268	Binds directly to 16S ribosomal RNA
K6J81_RS00655	COG0728	peptidoglycan biosynthetic process
K6J81_RS00660	COG0196	riboflavin kinase activity
K6J81_RS00675	COG1047	Peptidyl-prolyl cis-trans
K6J81_RS00680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6J81_RS00685	COG1966	Carbon starvation protein
K6J81_RS00700	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6J81_RS00705	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6J81_RS00715	COG3279	Response regulator of the LytR AlgR family
K6J81_RS00720	COG3275	phosphorelay sensor kinase activity
K6J81_RS00725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6J81_RS00730	COG1605	Chorismate mutase
K6J81_RS00730	COG0287	Prephenate dehydrogenase
K6J81_RS00740	COG0488	(ABC) transporter
K6J81_RS00750	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6J81_RS00760	COG5001	Diguanylate cyclase
K6J81_RS00765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6J81_RS00770	COG1605	Chorismate mutase
K6J81_RS00770	COG0077	Prephenate dehydratase
K6J81_RS00775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6J81_RS00780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6J81_RS00785	COG0564	pseudouridine synthase activity
K6J81_RS00795	COG0542	response to heat
K6J81_RS00835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6J81_RS00840	COG0826	peptidase U32
K6J81_RS00850	COG0745	RESPONSE REGULATOR receiver
K6J81_RS00855	COG5002	protein histidine kinase activity
K6J81_RS00865	COG0248	Ppx GppA phosphatase
K6J81_RS00870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6J81_RS00885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6J81_RS00900	COG3142	Participates in the control of copper homeostasis
K6J81_RS00905	COG0450	alkyl hydroperoxide reductase
K6J81_RS00910	COG0583	DNA-binding transcription factor activity
K6J81_RS00915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6J81_RS00925	COG0517	IMP dehydrogenase activity
K6J81_RS00940	COG1862	Preprotein translocase
K6J81_RS00945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J81_RS00950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J81_RS00955	COG0483	inositol monophosphate 1-phosphatase activity
K6J81_RS00965	COG1959	2 iron, 2 sulfur cluster binding
K6J81_RS00970	COG1104	cysteine desulfurase activity
K6J81_RS00975	COG0822	iron-sulfur transferase activity
K6J81_RS00985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6J81_RS00990	COG0443	Heat shock 70 kDa protein
K6J81_RS00995	COG0633	Ferredoxin
K6J81_RS01000	COG2975	iron-sulfur cluster assembly
K6J81_RS01005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6J81_RS01010	COG0105	UTP biosynthetic process
K6J81_RS01015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6J81_RS01025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6J81_RS01030	COG0124	histidyl-tRNA synthetase
K6J81_RS01035	COG2976	Protein conserved in bacteria
K6J81_RS01040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6J81_RS01045	COG1160	GTP binding
K6J81_RS01060	COG1570	exodeoxyribonuclease VII activity
K6J81_RS01065	COG0516	GMP reductase activity
K6J81_RS01065	COG0517	IMP dehydrogenase activity
K6J81_RS01070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6J81_RS01070	COG0519	Catalyzes the synthesis of GMP from XMP
K6J81_RS01080	COG1584	GPR1 FUN34 yaaH family protein
K6J81_RS01085	COG3433	isochorismatase activity
K6J81_RS01085	COG1535	isochorismatase
K6J81_RS01090	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6J81_RS01095	COG1169	isochorismate synthase
K6J81_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
K6J81_RS01110	COG4592	Periplasmic binding protein
K6J81_RS01115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J81_RS01120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J81_RS01125	COG1120	ATPase activity
K6J81_RS01135	COG0583	DNA-binding transcription factor activity
K6J81_RS01140	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K6J81_RS01145	COG1115	amino acid carrier protein
K6J81_RS01155	COG0583	DNA-binding transcription factor activity
K6J81_RS01170	COG4565	transcriptional regulatory protein
K6J81_RS01180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6J81_RS01185	COG0511	ligase activity, forming carbon-carbon bonds
K6J81_RS01185	COG5016	pyruvate
K6J81_RS01190	COG3630	sodium ion export across plasma membrane
K6J81_RS01200	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K6J81_RS01210	COG2301	Belongs to the HpcH HpaI aldolase family
K6J81_RS01215	COG3051	citrate lyase alpha subunit
K6J81_RS01235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6J81_RS01240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K6J81_RS01245	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K6J81_RS01300	COG1012	belongs to the aldehyde dehydrogenase family
K6J81_RS01320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6J81_RS01325	COG0840	transmembrane signaling receptor activity
K6J81_RS01330	COG3710	Transcriptional regulator
K6J81_RS01340	COG2165	general secretion pathway protein
K6J81_RS01355	COG4796	Type ii and iii secretion system protein
K6J81_RS01375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J81_RS01380	COG1459	type II secretion system
K6J81_RS01390	COG2207	Transcriptional regulator
K6J81_RS01395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K6J81_RS01400	COG0840	transmembrane signaling receptor activity
K6J81_RS01415	COG0739	heme binding
K6J81_RS01425	COG3064	Membrane
K6J81_RS01450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6J81_RS01455	COG2867	negative regulation of translational initiation
K6J81_RS01460	COG2914	Belongs to the UPF0125 (RnfH) family
K6J81_RS01465	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6J81_RS01470	COG0497	DNA recombination
K6J81_RS01475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6J81_RS01480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6J81_RS01490	COG0443	Heat shock 70 kDa protein
K6J81_RS01495	COG0484	heat shock protein binding
K6J81_RS01525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6J81_RS01535	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6J81_RS01570	COG0442	prolyl-tRNA aminoacylation
K6J81_RS01575	COG1720	tRNA m6t6A37 methyltransferase activity
K6J81_RS01580	COG0254	rRNA binding
K6J81_RS01585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6J81_RS01595	COG1671	Belongs to the UPF0178 family
K6J81_RS01605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J81_RS01620	COG3098	single-species biofilm formation
K6J81_RS01625	COG0564	pseudouridine synthase activity
K6J81_RS01630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6J81_RS01635	COG0142	geranyltranstransferase activity
K6J81_RS01640	COG1722	exodeoxyribonuclease VII activity
K6J81_RS01645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6J81_RS01655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6J81_RS01655	COG0301	tRNA thio-modification
K6J81_RS01660	COG0583	DNA-binding transcription factor activity
K6J81_RS01665	COG2363	Small membrane protein
K6J81_RS01670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6J81_RS01675	COG1611	Belongs to the LOG family
K6J81_RS01690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6J81_RS01690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6J81_RS01700	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K6J81_RS01705	COG1464	Belongs to the NlpA lipoprotein family
K6J81_RS01710	COG2011	ABC-type metal ion transport system permease component
K6J81_RS01715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6J81_RS01720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6J81_RS01725	COG1609	Transcriptional regulator
K6J81_RS01730	COG1263	PTS System
K6J81_RS01730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J81_RS01735	COG0366	Alpha amylase catalytic
K6J81_RS01765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6J81_RS01770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6J81_RS01775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6J81_RS01780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6J81_RS01785	COG0110	maltose O-acetyltransferase activity
K6J81_RS01805	COG1045	serine acetyltransferase
K6J81_RS01815	COG0438	transferase activity, transferring glycosyl groups
K6J81_RS01825	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K6J81_RS01855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6J81_RS01865	COG1596	polysaccharide export
K6J81_RS01890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6J81_RS01900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6J81_RS01905	COG0321	lipoyl(octanoyl) transferase activity
K6J81_RS01910	COG2921	Belongs to the UPF0250 family
K6J81_RS01915	COG1686	Belongs to the peptidase S11 family
K6J81_RS01920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6J81_RS01925	COG0772	Belongs to the SEDS family
K6J81_RS01930	COG0768	penicillin binding
K6J81_RS01935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6J81_RS01940	COG0799	negative regulation of ribosome biogenesis
K6J81_RS01945	COG1466	dna polymerase III delta subunit
K6J81_RS01950	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6J81_RS01955	COG0495	leucyl-tRNA aminoacylation
K6J81_RS01960	COG2888	peptidyl-tyrosine sulfation
K6J81_RS01965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6J81_RS01970	COG4535	Mg2 and Co2 transporter CorC
K6J81_RS01980	COG1702	phosphate starvation-inducible protein PhoH
K6J81_RS01985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6J81_RS01990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J81_RS01995	COG2190	(PTS) system
K6J81_RS02005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J81_RS02010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6J81_RS02015	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6J81_RS02020	COG3115	cell septum assembly
K6J81_RS02025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6J81_RS02040	COG0789	Transcriptional regulator
K6J81_RS02045	COG1585	Membrane protein implicated in regulation of membrane protease activity
K6J81_RS02050	COG0330	HflC and HflK could
K6J81_RS02055	COG3118	belongs to the thioredoxin family
K6J81_RS02060	COG0300	oxidoreductase activity
K6J81_RS02065	COG1090	epimerase
K6J81_RS02070	COG0622	Phosphoesterase
K6J81_RS02085	COG3710	Transcriptional regulator
K6J81_RS02090	COG0326	Molecular chaperone. Has ATPase activity
K6J81_RS02095	COG0563	adenylate kinase activity
K6J81_RS02100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6J81_RS02115	COG0367	asparagine synthase
K6J81_RS02120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6J81_RS02120	COG4651	solute:proton antiporter activity
K6J81_RS02125	COG1940	carbohydrate kinase activity
K6J81_RS02125	COG1846	Transcriptional regulator
K6J81_RS02130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6J81_RS02135	COG2190	(PTS) system
K6J81_RS02135	COG1263	PTS System
K6J81_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J81_RS02150	COG0101	tRNA pseudouridine synthase activity
K6J81_RS02155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6J81_RS02160	COG0285	dihydrofolate synthase activity
K6J81_RS02165	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6J81_RS02170	COG1286	toxin biosynthetic process
K6J81_RS02175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6J81_RS02180	COG2056	Na+-H+ antiporter family
K6J81_RS02185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6J81_RS02200	COG0346	lactoylglutathione lyase activity
K6J81_RS02205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6J81_RS02225	COG4656	Part of a membrane complex involved in electron transport
K6J81_RS02230	COG2878	Part of a membrane complex involved in electron transport
K6J81_RS02235	COG4657	Part of a membrane complex involved in electron transport
K6J81_RS02245	COG0556	nucleotide-excision repair
K6J81_RS02250	COG2204	response regulator
K6J81_RS02255	COG2198	Histidine kinase
K6J81_RS02260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6J81_RS02265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6J81_RS02270	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6J81_RS02275	COG0315	cyclic pyranopterin monophosphate synthase activity
K6J81_RS02280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6J81_RS02285	COG0314	molybdopterin synthase activity
K6J81_RS02290	COG2199	diguanylate cyclase activity
K6J81_RS02295	COG0517	IMP dehydrogenase activity
K6J81_RS02295	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6J81_RS02295	COG0617	tRNA 3'-terminal CCA addition
K6J81_RS02305	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6J81_RS02315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J81_RS02315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J81_RS02325	COG0572	uridine kinase
K6J81_RS02330	COG2982	Protein involved in outer membrane biogenesis
K6J81_RS02335	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6J81_RS02340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6J81_RS02350	COG2067	long-chain fatty acid transport protein
K6J81_RS02365	COG0183	Belongs to the thiolase family
K6J81_RS02375	COG0778	Nitroreductase
K6J81_RS02380	COG0583	DNA-binding transcription factor activity
K6J81_RS02385	COG0745	RESPONSE REGULATOR receiver
K6J81_RS02390	COG2832	Protein of unknown function (DUF454)
K6J81_RS02395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6J81_RS02405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K6J81_RS02410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6J81_RS02420	COG2983	Belongs to the UPF0260 family
K6J81_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
K6J81_RS02430	COG0616	signal peptide processing
K6J81_RS02440	COG1522	sequence-specific DNA binding
K6J81_RS02445	COG1946	Acyl-CoA thioesterase
K6J81_RS02465	COG3706	GGDEF domain
K6J81_RS02475	COG0640	Transcriptional regulator
K6J81_RS02480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6J81_RS02505	COG1881	PFAM PEBP family protein
K6J81_RS02520	COG0009	L-threonylcarbamoyladenylate synthase
K6J81_RS02535	COG2201	protein-glutamate methylesterase activity
K6J81_RS02545	COG5002	protein histidine kinase activity
K6J81_RS02550	COG4191	Histidine kinase
K6J81_RS02555	COG5001	Diguanylate cyclase
K6J81_RS02555	COG3300	MHYT domain
K6J81_RS02560	COG2204	response regulator
K6J81_RS02580	COG0601	transmembrane transport
K6J81_RS02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J81_RS02590	COG0444	Belongs to the ABC transporter superfamily
K6J81_RS02595	COG4608	Belongs to the ABC transporter superfamily
K6J81_RS02600	COG0435	Glutathione S-transferase
K6J81_RS02605	COG0280	phosphate acetyltransferase
K6J81_RS02605	COG0857	belongs to the CobB CobQ family
K6J81_RS02610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6J81_RS02615	COG3092	negative regulation of chromosome organization
K6J81_RS02620	COG4628	conserved protein (DUF2132)
K6J81_RS02630	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6J81_RS02640	COG2199	diguanylate cyclase activity
K6J81_RS02640	COG2203	Gaf domain
K6J81_RS02645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6J81_RS02655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K6J81_RS02660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6J81_RS02665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6J81_RS02670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6J81_RS02675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6J81_RS02680	COG0156	8-amino-7-oxononanoate synthase activity
K6J81_RS02685	COG2226	methyltransferase
K6J81_RS02690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6J81_RS02700	COG0501	Belongs to the peptidase M48B family
K6J81_RS02710	COG0300	oxidoreductase activity
K6J81_RS02725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6J81_RS02735	COG2268	Band 7 protein
K6J81_RS02745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6J81_RS02750	COG2915	High frequency lysogenization protein hflD homolog
K6J81_RS02755	COG0482	sulfurtransferase activity
K6J81_RS02760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J81_RS02765	COG2916	Histone family protein nucleoid-structuring protein H-NS
K6J81_RS02770	COG1757	Na H antiporter
K6J81_RS02775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6J81_RS02780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6J81_RS02785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6J81_RS02790	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6J81_RS02790	COG0131	Imidazoleglycerol-phosphate dehydratase
K6J81_RS02795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6J81_RS02800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6J81_RS02805	COG0107	imidazoleglycerol-phosphate synthase activity
K6J81_RS02810	COG0140	phosphoribosyl-ATP diphosphatase activity
K6J81_RS02810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6J81_RS02815	COG1187	pseudouridine synthase activity
K6J81_RS02825	COG1278	Cold shock
K6J81_RS02830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6J81_RS02835	COG0542	response to heat
K6J81_RS02840	COG2985	domain, Protein
K6J81_RS02840	COG3273	potassium ion transport
K6J81_RS02845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6J81_RS02850	COG1012	belongs to the aldehyde dehydrogenase family
K6J81_RS02850	COG1454	alcohol dehydrogenase
K6J81_RS02855	COG1737	Transcriptional regulator
K6J81_RS02860	COG0076	glutamate decarboxylase activity
K6J81_RS02870	COG2431	L-lysine efflux transmembrane transporter activity
K6J81_RS02880	COG3070	regulator of competence-specific genes
K6J81_RS02895	COG3852	Histidine kinase
K6J81_RS02905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6J81_RS02920	COG0189	ligase activity
K6J81_RS02920	COG4067	protein conserved in archaea
K6J81_RS02925	COG0500	methyltransferase
K6J81_RS02930	COG4106	trans-aconitate 2-methyltransferase activity
K6J81_RS02940	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6J81_RS02945	COG1435	thymidine kinase activity
K6J81_RS02955	COG0159	tryptophan synthase activity
K6J81_RS02960	COG0133	tryptophan synthase activity
K6J81_RS02965	COG0134	indole-3-glycerol-phosphate synthase activity
K6J81_RS02965	COG0135	phosphoribosylanthranilate isomerase activity
K6J81_RS02970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6J81_RS02975	COG0512	Glutamine amidotransferase of anthranilate synthase
K6J81_RS02980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6J81_RS02990	COG0613	PHP domain protein
K6J81_RS02995	COG0009	L-threonylcarbamoyladenylate synthase
K6J81_RS03000	COG1187	pseudouridine synthase activity
K6J81_RS03005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6J81_RS03010	COG4988	ABC transporter
K6J81_RS03015	COG0492	ferredoxin-NADP+ reductase activity
K6J81_RS03025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6J81_RS03030	COG3706	GGDEF domain
K6J81_RS03035	COG2949	membrane
K6J81_RS03045	COG0281	malic enzyme
K6J81_RS03055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6J81_RS03075	COG2885	chlorophyll binding
K6J81_RS03110	COG2986	histidine ammonia-lyase
K6J81_RS03115	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6J81_RS03120	COG0010	Belongs to the arginase family
K6J81_RS03125	COG1228	amidohydrolase
K6J81_RS03140	COG3099	Belongs to the UPF0263 family
K6J81_RS03145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6J81_RS03155	COG5001	Diguanylate cyclase
K6J81_RS03160	COG0417	DNA replication proofreading
K6J81_RS03165	COG2197	response regulator
K6J81_RS03210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6J81_RS03215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J81_RS03215	COG0072	phenylalanine-tRNA ligase activity
K6J81_RS03220	COG0776	regulation of translation
K6J81_RS03250	COG1346	cytolysis
K6J81_RS03255	COG1380	Effector of murein hydrolase LrgA
K6J81_RS03260	COG2925	Exonuclease
K6J81_RS03265	COG1823	symporter activity
K6J81_RS03270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J81_RS03275	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6J81_RS03280	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6J81_RS03300	COG4139	cobalamin transport
K6J81_RS03350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6J81_RS03355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6J81_RS03360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6J81_RS03370	COG1054	Belongs to the UPF0176 family
K6J81_RS03380	COG2814	Major facilitator Superfamily
K6J81_RS03390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6J81_RS03420	COG3108	Peptidase M15
K6J81_RS03425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6J81_RS03440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6J81_RS03465	COG1846	Transcriptional regulator
K6J81_RS03470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6J81_RS03475	COG0726	polysaccharide deacetylase
K6J81_RS03480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6J81_RS03490	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6J81_RS03495	COG1486	melibiose metabolic process
K6J81_RS03505	COG1609	Transcriptional regulator
K6J81_RS03510	COG2943	transferase activity, transferring hexosyl groups
K6J81_RS03515	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K6J81_RS03520	COG0840	transmembrane signaling receptor activity
K6J81_RS03535	COG1448	Aminotransferase
K6J81_RS03540	COG2770	Histidine kinase
K6J81_RS03540	COG3437	response regulator, receiver
K6J81_RS03545	COG0351	phosphomethylpyrimidine kinase
K6J81_RS03550	COG0017	Asparaginyl-tRNA synthetase
K6J81_RS03560	COG0720	synthase
K6J81_RS03565	COG1760	l-serine dehydratase
K6J81_RS03570	COG0814	amino acid
K6J81_RS03575	COG0494	nUDIX hydrolase
K6J81_RS03580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6J81_RS03595	COG3106	COG3106 Predicted ATPase
K6J81_RS03600	COG3768	UPF0283 membrane protein
K6J81_RS03610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J81_RS03625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6J81_RS03635	COG0471	metal ion transport
K6J81_RS03640	COG4191	Histidine kinase
K6J81_RS03640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J81_RS03650	COG2990	Protein conserved in bacteria
K6J81_RS03655	COG3713	MltA-interacting MipA family protein
K6J81_RS03660	COG2205	protein histidine kinase activity
K6J81_RS03665	COG0745	RESPONSE REGULATOR receiver
K6J81_RS03690	COG1129	ABC transporter
K6J81_RS03730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6J81_RS03735	COG0372	Belongs to the citrate synthase family
K6J81_RS03765	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6J81_RS03775	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K6J81_RS03785	COG0625	glutathione transferase activity
K6J81_RS03790	COG3437	response regulator, receiver
K6J81_RS03805	COG3706	GGDEF domain
K6J81_RS03815	COG1254	Belongs to the acylphosphatase family
K6J81_RS03820	COG2920	part of a sulfur-relay system
K6J81_RS03825	COG0670	Belongs to the BI1 family
K6J81_RS03830	COG1126	abc transporter atp-binding protein
K6J81_RS03835	COG0765	amino acid transport
K6J81_RS03840	COG4597	amino acid ABC transporter
K6J81_RS03845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J81_RS03855	COG0561	phosphatase activity
K6J81_RS03860	COG0602	queuosine metabolic process
K6J81_RS03865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6J81_RS03895	COG3706	GGDEF domain
K6J81_RS03900	COG0443	Heat shock 70 kDa protein
K6J81_RS03905	COG0443	Heat shock 70 kDa protein
K6J81_RS03945	COG0443	Heat shock 70 kDa protein
K6J81_RS03950	COG0095	Lipoate-protein ligase
K6J81_RS03960	COG0583	DNA-binding transcription factor activity
K6J81_RS03965	COG0477	Major facilitator Superfamily
K6J81_RS03970	COG0415	Belongs to the DNA photolyase family
K6J81_RS03985	COG0745	RESPONSE REGULATOR receiver
K6J81_RS03995	COG0643	Histidine kinase
K6J81_RS03995	COG2198	Histidine kinase
K6J81_RS04000	COG0643	Histidine kinase
K6J81_RS04000	COG0784	Response regulator, receiver
K6J81_RS04000	COG2198	Histidine kinase
K6J81_RS04005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6J81_RS04015	COG2201	protein-glutamate methylesterase activity
K6J81_RS04020	COG0835	chemotaxis
K6J81_RS04025	COG0840	transmembrane signaling receptor activity
K6J81_RS04025	COG3290	protein histidine kinase activity
K6J81_RS04040	COG0513	Belongs to the DEAD box helicase family
K6J81_RS04050	COG1538	Outer membrane efflux protein
K6J81_RS04055	COG1566	PFAM secretion protein HlyD family protein
K6J81_RS04060	COG2814	Major facilitator Superfamily
K6J81_RS04070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6J81_RS04080	COG3501	Rhs element vgr protein
K6J81_RS04090	COG3675	Pfam Lipase (class 3)
K6J81_RS04105	COG1280	lysine exporter protein (LysE YggA)
K6J81_RS04110	COG1115	amino acid carrier protein
K6J81_RS04125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6J81_RS04135	COG1177	transmembrane transport
K6J81_RS04145	COG3842	ATPase activity
K6J81_RS04170	COG0589	response to stress
K6J81_RS04175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6J81_RS04190	COG2217	Heavy metal translocating P-type atpase
K6J81_RS04200	COG2010	Cytochrome c
K6J81_RS04215	COG3278	Belongs to the heme-copper respiratory oxidase family
K6J81_RS04230	COG2205	protein histidine kinase activity
K6J81_RS04230	COG0784	Response regulator, receiver
K6J81_RS04255	COG2994	toxin metabolic process
K6J81_RS04260	COG1073	alpha beta
K6J81_RS04260	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
K6J81_RS04260	COG3064	Membrane
K6J81_RS04275	COG4128	Pfam Zonular occludens toxin
K6J81_RS04305	COG1476	TRANSCRIPTIONal
K6J81_RS04325	COG1476	TRANSCRIPTIONal
K6J81_RS04400	COG3120	sequence-specific DNA binding
K6J81_RS04405	COG1067	ATP-dependent peptidase activity
K6J81_RS04410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6J81_RS04425	COG0488	(ABC) transporter
K6J81_RS04435	COG0116	Belongs to the methyltransferase superfamily
K6J81_RS04435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6J81_RS04445	COG0167	dihydroorotate dehydrogenase activity
K6J81_RS04460	COG0308	aminopeptidase N
K6J81_RS04475	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6J81_RS04480	COG1956	GAF domain-containing protein
K6J81_RS04485	COG1132	(ABC) transporter
K6J81_RS04490	COG2995	paraquat-inducible protein a
K6J81_RS04495	COG3008	intermembrane lipid transfer
K6J81_RS04505	COG2996	Protein conserved in bacteria
K6J81_RS04520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6J81_RS04525	COG1666	GTP binding
K6J81_RS04530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6J81_RS04545	COG0437	4 iron, 4 sulfur cluster binding
K6J81_RS04550	COG0243	molybdopterin cofactor binding
K6J81_RS04550	COG3383	formate dehydrogenase (NAD+) activity
K6J81_RS04580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6J81_RS04585	COG0488	(ABC) transporter
K6J81_RS04590	COG3852	Histidine kinase
K6J81_RS04595	COG2204	response regulator
K6J81_RS04605	COG4662	Binding-protein-dependent transport system inner membrane component
K6J81_RS04610	COG3842	ATPase activity
K6J81_RS04615	COG0746	molybdenum cofactor guanylyltransferase activity
K6J81_RS04640	COG1940	carbohydrate kinase activity
K6J81_RS04645	COG3148	PFAM DTW domain containing protein
K6J81_RS04655	COG0840	transmembrane signaling receptor activity
K6J81_RS04660	COG0791	NLP P60 protein
K6J81_RS04670	COG3001	Fructosamine kinase
K6J81_RS04680	COG0534	Mate efflux family protein
K6J81_RS04690	COG1793	dna ligase
K6J81_RS04700	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6J81_RS04705	COG0848	biopolymer transport protein
K6J81_RS04710	COG0811	peptide transport
K6J81_RS04730	COG1175	transmembrane transport
K6J81_RS04735	COG0395	ABC-type sugar transport system, permease component
K6J81_RS04740	COG3842	ATPase activity
K6J81_RS04745	COG1349	DNA-binding transcription factor activity
K6J81_RS04750	COG0584	glycerophosphoryl diester phosphodiesterase
K6J81_RS04755	COG2731	YhcH YjgK YiaL family protein
K6J81_RS04760	COG0251	oxidation-reduction process
K6J81_RS04765	COG1609	Transcriptional regulator
K6J81_RS04770	COG2723	6-phospho-beta-galactosidase activity
K6J81_RS04780	COG0583	DNA-binding transcription factor activity
K6J81_RS04800	COG1136	(ABC) transporter
K6J81_RS04800	COG0577	efflux transmembrane transporter activity
K6J81_RS04805	COG1136	(ABC) transporter
K6J81_RS04805	COG0577	efflux transmembrane transporter activity
K6J81_RS04810	COG1136	(ABC) transporter
K6J81_RS04810	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6J81_RS04815	COG1294	oxidase, subunit
K6J81_RS04820	COG1271	oxidase subunit
K6J81_RS04860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6J81_RS04870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6J81_RS04890	COG0753	catalase activity
K6J81_RS04920	COG2199	diguanylate cyclase activity
K6J81_RS04920	COG2200	EAL domain
K6J81_RS04930	COG2017	converts alpha-aldose to the beta-anomer
K6J81_RS04935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6J81_RS04940	COG1085	galactose-1-phosphate uridylyltransferase
K6J81_RS04985	COG0784	Response regulator, receiver
K6J81_RS04985	COG0835	chemotaxis
K6J81_RS04995	COG4565	transcriptional regulatory protein
K6J81_RS05000	COG3290	protein histidine kinase activity
K6J81_RS05015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J81_RS05045	COG3063	Type IV pilus biogenesis stability protein PilW
K6J81_RS05055	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6J81_RS05060	COG1451	nucleotide metabolic process
K6J81_RS05070	COG0583	DNA-binding transcription factor activity
K6J81_RS05105	COG1538	Outer membrane efflux protein
K6J81_RS05120	COG1748	Saccharopine dehydrogenase
K6J81_RS05130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6J81_RS05140	COG0577	efflux transmembrane transporter activity
K6J81_RS05145	COG4181	ATPase activity
K6J81_RS05150	COG0534	Mate efflux family protein
K6J81_RS05155	COG0702	epimerase
K6J81_RS05165	COG2814	Major facilitator Superfamily
K6J81_RS05170	COG1187	pseudouridine synthase activity
K6J81_RS05175	COG1061	Type III restriction enzyme res subunit
K6J81_RS05195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6J81_RS05200	COG2203	Gaf domain
K6J81_RS05200	COG3706	GGDEF domain
K6J81_RS05200	COG4251	negative regulation of phosphorylation
K6J81_RS05200	COG5001	Diguanylate cyclase
K6J81_RS05210	COG0840	transmembrane signaling receptor activity
K6J81_RS05240	COG4934	collagen metabolic process
K6J81_RS05255	COG2205	protein histidine kinase activity
K6J81_RS05255	COG0784	Response regulator, receiver
K6J81_RS05260	COG2239	Acts as a magnesium transporter
K6J81_RS05270	COG0814	amino acid
K6J81_RS05275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J81_RS05280	COG1131	(ABC) transporter
K6J81_RS05285	COG0842	Transport permease protein
K6J81_RS05295	COG3313	Fe-S protein
K6J81_RS05305	COG4134	Bacterial extracellular solute-binding protein
K6J81_RS05310	COG4135	transport system, permease component
K6J81_RS05315	COG4136	ATPase activity
K6J81_RS05320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6J81_RS05325	COG0564	pseudouridine synthase activity
K6J81_RS05330	COG0733	neurotransmitter:sodium symporter activity
K6J81_RS05340	COG0626	cystathionine gamma-synthase activity
K6J81_RS05345	COG2818	Glycosylase
K6J81_RS05360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J81_RS05375	COG1842	Phage shock protein A
K6J81_RS05380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6J81_RS05390	COG4168	peptide transport system, permease
K6J81_RS05405	COG4172	Belongs to the ABC transporter superfamily
K6J81_RS05420	COG1227	inorganic diphosphatase activity
K6J81_RS05440	COG0243	molybdopterin cofactor binding
K6J81_RS05445	COG3005	denitrification pathway
K6J81_RS05450	COG4459	periplasmic nitrate reductase
K6J81_RS05460	COG2116	formate transmembrane transporter activity
K6J81_RS05470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6J81_RS05475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6J81_RS05490	COG1607	acyl-coa hydrolase
K6J81_RS05495	COG2350	Protein conserved in bacteria
K6J81_RS05505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6J81_RS05525	COG0612	Peptidase, M16
K6J81_RS05530	COG5001	Diguanylate cyclase
K6J81_RS05535	COG1032	radical SAM domain protein
K6J81_RS05555	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6J81_RS05565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6J81_RS05570	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6J81_RS05575	COG0745	RESPONSE REGULATOR receiver
K6J81_RS05580	COG3381	protein complex oligomerization
K6J81_RS05585	COG1609	Transcriptional regulator
K6J81_RS05590	COG3070	regulator of competence-specific genes
K6J81_RS05610	COG0297	glycogen (starch) synthase activity
K6J81_RS05620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6J81_RS05645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6J81_RS05650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6J81_RS05680	COG1012	belongs to the aldehyde dehydrogenase family
K6J81_RS05685	COG1309	transcriptional regulator
K6J81_RS05705	COG0668	transmembrane transport
K6J81_RS05710	COG2995	paraquat-inducible protein a
K6J81_RS05715	COG3008	intermembrane lipid transfer
K6J81_RS05715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6J81_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J81_RS05740	COG0582	viral genome integration into host DNA
K6J81_RS05745	COG0582	viral genome integration into host DNA
K6J81_RS05750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6J81_RS05770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6J81_RS05790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K6J81_RS05810	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
K6J81_RS05815	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
K6J81_RS05820	COG1737	Transcriptional regulator
K6J81_RS05825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6J81_RS05830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6J81_RS05835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6J81_RS05840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6J81_RS05850	COG1940	carbohydrate kinase activity
K6J81_RS05855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6J81_RS05860	COG4409	exo-alpha-(2->6)-sialidase activity
K6J81_RS05870	COG2003	Belongs to the UPF0758 family
K6J81_RS05890	COG3941	tape measure
K6J81_RS05930	COG0488	(ABC) transporter
K6J81_RS06010	COG0415	Belongs to the DNA photolyase family
K6J81_RS06020	COG4628	conserved protein (DUF2132)
K6J81_RS06025	COG3284	Transcriptional regulator
K6J81_RS06030	COG1012	belongs to the aldehyde dehydrogenase family
K6J81_RS06040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6J81_RS06045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6J81_RS06050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6J81_RS06060	COG2207	Transcriptional regulator
K6J81_RS06065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6J81_RS06065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6J81_RS06065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J81_RS06070	COG1482	cell wall glycoprotein biosynthetic process
K6J81_RS06080	COG0784	Response regulator, receiver
K6J81_RS06080	COG5002	protein histidine kinase activity
K6J81_RS06090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6J81_RS06100	COG2885	chlorophyll binding
K6J81_RS06105	COG0823	Involved in the tonB-independent uptake of proteins
K6J81_RS06120	COG0811	peptide transport
K6J81_RS06125	COG0824	Thioesterase
K6J81_RS06135	COG4890	Cyd operon protein YbgT
K6J81_RS06140	COG1294	oxidase, subunit
K6J81_RS06145	COG1271	oxidase subunit
K6J81_RS06155	COG0632	four-way junction helicase activity
K6J81_RS06160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6J81_RS06165	COG0215	cysteine-tRNA ligase activity
K6J81_RS06170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6J81_RS06175	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J81_RS06180	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6J81_RS06185	COG3012	SEC-C Motif Domain Protein
K6J81_RS06190	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6J81_RS06195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6J81_RS06200	COG1199	ATP-dependent helicase activity
K6J81_RS06205	COG0730	response to heat
K6J81_RS06210	COG3923	Primosomal replication protein n
K6J81_RS06220	COG0840	transmembrane signaling receptor activity
K6J81_RS06225	COG0708	Exodeoxyribonuclease III
K6J81_RS06230	COG4160	amino acid transport
K6J81_RS06255	COG1882	Formate acetyltransferase
K6J81_RS06265	COG0840	transmembrane signaling receptor activity
K6J81_RS06270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6J81_RS06280	COG3013	Belongs to the UPF0304 family
K6J81_RS06285	COG2766	serine protein kinase
K6J81_RS06290	COG2718	Belongs to the UPF0229 family
K6J81_RS06295	COG2719	SpoVR family
K6J81_RS06300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6J81_RS06305	COG2835	tetraacyldisaccharide 4'-kinase activity
K6J81_RS06310	COG1663	tetraacyldisaccharide 4'-kinase activity
K6J81_RS06315	COG1132	(ABC) transporter
K6J81_RS06320	COG0658	competence protein
K6J81_RS06320	COG2333	competence protein COMEC
K6J81_RS06330	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6J81_RS06335	COG1136	(ABC) transporter
K6J81_RS06340	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6J81_RS06370	COG1252	NADH dehydrogenase
K6J81_RS06375	COG3150	esterase
K6J81_RS06400	COG0537	adenosine 5'-monophosphoramidase activity
K6J81_RS06415	COG2186	Transcriptional regulator
K6J81_RS06420	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6J81_RS06425	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6J81_RS06440	COG0686	Belongs to the AlaDH PNT family
K6J81_RS06450	COG0583	DNA-binding transcription factor activity
K6J81_RS06470	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6J81_RS06475	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6J81_RS06480	COG0776	regulation of translation
K6J81_RS06485	COG0539	negative regulation of cytoplasmic translation
K6J81_RS06490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6J81_RS06495	COG1555	photosystem II stabilization
K6J81_RS06500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6J81_RS06505	COG0776	regulation of translation
K6J81_RS06510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6J81_RS06515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6J81_RS06525	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6J81_RS06535	COG4191	Histidine kinase
K6J81_RS06545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6J81_RS06550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6J81_RS06555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6J81_RS06560	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6J81_RS06570	COG3300	MHYT domain
K6J81_RS06570	COG5001	Diguanylate cyclase
K6J81_RS06580	COG4589	Belongs to the CDS family
K6J81_RS06615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6J81_RS06625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J81_RS06640	COG0243	molybdopterin cofactor binding
K6J81_RS06645	COG3005	denitrification pathway
K6J81_RS06650	COG3325	Belongs to the glycosyl hydrolase 18 family
K6J81_RS06650	COG3469	chitinase activity
K6J81_RS06655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6J81_RS06665	COG2951	lytic endotransglycosylase activity
K6J81_RS06670	COG3100	YcgL domain-containing protein
K6J81_RS06675	COG0850	regulation of cytokinetic process
K6J81_RS06680	COG2894	cell division
K6J81_RS06685	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6J81_RS06690	COG3015	lipoprotein NlpE involved in copper resistance
K6J81_RS06710	COG0477	Major facilitator Superfamily
K6J81_RS06725	COG0840	transmembrane signaling receptor activity
K6J81_RS06730	COG1396	sequence-specific DNA binding
K6J81_RS06735	COG3135	benzoate transporter
K6J81_RS06755	COG0596	Alpha beta hydrolase
K6J81_RS06760	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6J81_RS06765	COG1169	isochorismate synthase
K6J81_RS06770	COG0436	Aminotransferase
K6J81_RS06775	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6J81_RS06800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6J81_RS06805	COG0318	PFAM AMP-dependent synthetase and ligase
K6J81_RS06810	COG0596	Alpha beta hydrolase
K6J81_RS06825	COG1214	PFAM Peptidase M22, glycoprotease
K6J81_RS06830	COG1199	ATP-dependent helicase activity
K6J81_RS06840	COG0788	formyltetrahydrofolate deformylase activity
K6J81_RS06845	COG1902	pentaerythritol trinitrate reductase activity
K6J81_RS06845	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6J81_RS06850	COG0616	signal peptide processing
K6J81_RS06855	COG0252	asparaginase activity
K6J81_RS06860	COG3139	Protein of unknown function (DUF1315)
K6J81_RS06870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J81_RS06875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6J81_RS06880	COG0676	glucose-6-phosphate 1-epimerase activity
K6J81_RS06890	COG2226	methyltransferase
K6J81_RS06905	COG0835	chemotaxis
K6J81_RS06905	COG0784	Response regulator, receiver
K6J81_RS06910	COG1940	carbohydrate kinase activity
K6J81_RS06920	COG4667	esterase of the alpha-beta hydrolase superfamily
K6J81_RS06935	COG0733	neurotransmitter:sodium symporter activity
K6J81_RS06945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J81_RS06945	COG1263	PTS System
K6J81_RS06950	COG0084	hydrolase, TatD family'
K6J81_RS06960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6J81_RS06965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6J81_RS06970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6J81_RS06975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6J81_RS06980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6J81_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
K6J81_RS06995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6J81_RS07000	COG0416	fatty acid biosynthetic process
K6J81_RS07005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K6J81_RS07010	COG1399	metal-binding, possibly nucleic acid-binding protein
K6J81_RS07015	COG0424	maF-like protein
K6J81_RS07020	COG0564	pseudouridine synthase activity
K6J81_RS07025	COG1530	ribonuclease E activity
K6J81_RS07030	COG0659	secondary active sulfate transmembrane transporter activity
K6J81_RS07040	COG1012	belongs to the aldehyde dehydrogenase family
K6J81_RS07040	COG1454	alcohol dehydrogenase
K6J81_RS07045	COG2095	MarC family integral membrane protein
K6J81_RS07055	COG1757	Na H antiporter
K6J81_RS07065	COG3081	Nucleoid-associated protein
K6J81_RS07070	COG3082	Protein of unknown function (DUF1414)
K6J81_RS07075	COG3083	sulfuric ester hydrolase activity
K6J81_RS07095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6J81_RS07100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6J81_RS07120	COG2853	Lipoprotein
K6J81_RS07130	COG3088	subunit of a heme lyase
K6J81_RS07130	COG4235	cytochrome complex assembly
K6J81_RS07135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6J81_RS07140	COG1138	Cytochrome C-type biogenesis protein
K6J81_RS07145	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K6J81_RS07155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6J81_RS07160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6J81_RS07175	COG0835	chemotaxis
K6J81_RS07185	COG1192	Involved in chromosome partitioning
K6J81_RS07190	COG2201	protein-glutamate methylesterase activity
K6J81_RS07195	COG2198	Histidine kinase
K6J81_RS07195	COG0784	Response regulator, receiver
K6J81_RS07195	COG0643	Histidine kinase
K6J81_RS07200	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K6J81_RS07230	COG2062	phosphohistidine phosphatase, SixA
K6J81_RS07235	COG1025	Belongs to the peptidase M16 family
K6J81_RS07245	COG0018	arginyl-trna synthetase
K6J81_RS07265	COG1918	ferrous iron import across plasma membrane
K6J81_RS07270	COG4977	sequence-specific DNA binding
K6J81_RS07275	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K6J81_RS07280	COG1121	(ABC) transporter
K6J81_RS07285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6J81_RS07295	COG0045	succinate-CoA ligase (ADP-forming) activity
K6J81_RS07300	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6J81_RS07315	COG1053	succinate dehydrogenase
K6J81_RS07320	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6J81_RS07325	COG2009	succinate dehydrogenase
K6J81_RS07330	COG0372	Belongs to the citrate synthase family
K6J81_RS07335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6J81_RS07345	COG0033	Phosphoglucomutase
K6J81_RS07350	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6J81_RS07355	COG0596	Alpha beta hydrolase
K6J81_RS07370	COG1346	cytolysis
K6J81_RS07380	COG0583	DNA-binding transcription factor activity
K6J81_RS07390	COG0735	belongs to the Fur family
K6J81_RS07395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6J81_RS07400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6J81_RS07405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6J81_RS07415	COG0431	NADPH-dependent FMN reductase
K6J81_RS07425	COG3101	peptidyl-lysine hydroxylation
K6J81_RS07430	COG2860	membrane
K6J81_RS07435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6J81_RS07440	COG2890	protein-(glutamine-N5) methyltransferase activity
K6J81_RS07445	COG2840	Smr protein MutS2
K6J81_RS07455	COG1684	flagellar biosynthetic protein fliR
K6J81_RS07460	COG1987	bacterial-type flagellum assembly
K6J81_RS07485	COG1580	Controls the rotational direction of flagella during chemotaxis
K6J81_RS07510	COG1317	bacterial-type flagellum organization
K6J81_RS07515	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6J81_RS07525	COG1677	Flagellar hook-basal body complex protein FliE
K6J81_RS07545	COG1516	flagellar protein fliS
K6J81_RS07555	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6J81_RS07560	COG1334	flagellar protein FlaG
K6J81_RS07565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J81_RS07570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J81_RS07575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J81_RS07580	COG2837	iron assimilation
K6J81_RS07600	COG1393	Belongs to the ArsC family
K6J81_RS07610	COG1876	peptidase activity
K6J81_RS07620	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6J81_RS07635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6J81_RS07640	COG0840	transmembrane signaling receptor activity
K6J81_RS07655	COG4783	chaperone-mediated protein folding
K6J81_RS07660	COG1393	Belongs to the ArsC family
K6J81_RS07680	COG2233	PERMEase
K6J81_RS07685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6J81_RS07695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6J81_RS07700	COG2912	Transglutaminase-like superfamily
K6J81_RS07710	COG2890	protein-(glutamine-N5) methyltransferase activity
K6J81_RS07715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6J81_RS07720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6J81_RS07725	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6J81_RS07730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6J81_RS07735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6J81_RS07740	COG0193	aminoacyl-tRNA hydrolase activity
K6J81_RS07745	COG0012	GTP binding
K6J81_RS07830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J81_RS07835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J81_RS07850	COG3951	Flagellar rod assembly protein muramidase FlgJ
K6J81_RS07850	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6J81_RS07855	COG1706	bacterial-type flagellum-dependent cell motility
K6J81_RS07860	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6J81_RS07870	COG4787	bacterial-type flagellum-dependent cell motility
K6J81_RS07875	COG1749	Flagellar hook protein flgE
K6J81_RS07890	COG1815	bacterial-type flagellum-dependent cell motility
K6J81_RS07895	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6J81_RS07900	COG0784	Response regulator, receiver
K6J81_RS07900	COG0835	chemotaxis
K6J81_RS07935	COG3433	isochorismatase activity
K6J81_RS07935	COG2226	methyltransferase
K6J81_RS07935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6J81_RS07940	COG2375	cellular response to nickel ion
K6J81_RS07945	COG1629	transport
K6J81_RS07945	COG4774	siderophore transport
K6J81_RS07960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6J81_RS07965	COG2217	Heavy metal translocating P-type atpase
K6J81_RS07965	COG2608	mercury ion transmembrane transporter activity
K6J81_RS07980	COG3735	TraB family
K6J81_RS07995	COG2840	Smr protein MutS2
K6J81_RS08000	COG1187	pseudouridine synthase activity
K6J81_RS08010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6J81_RS08015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6J81_RS08020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6J81_RS08025	COG0121	glutamine amidotransferase
K6J81_RS08030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6J81_RS08050	COG0328	RNA-DNA hybrid ribonuclease activity
K6J81_RS08055	COG2226	methyltransferase
K6J81_RS08060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6J81_RS08065	COG0741	lytic transglycosylase activity
K6J81_RS08065	COG1388	LysM domain
K6J81_RS08070	COG3021	interspecies interaction between organisms
K6J81_RS08075	COG0347	Belongs to the P(II) protein family
K6J81_RS08080	COG3479	Phenolic acid decarboxylase
K6J81_RS08090	COG0037	tRNA processing
K6J81_RS08095	COG0825	malonyl-CoA metabolic process
K6J81_RS08100	COG0587	DNA-directed DNA polymerase activity
K6J81_RS08105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6J81_RS08110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J81_RS08115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J81_RS08120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6J81_RS08125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J81_RS08130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6J81_RS08140	COG0750	zinc metalloprotease
K6J81_RS08145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6J81_RS08150	COG0575	Belongs to the CDS family
K6J81_RS08155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6J81_RS08160	COG0233	cytoplasmic translational termination
K6J81_RS08165	COG0528	UMP kinase activity
K6J81_RS08170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6J81_RS08175	COG0052	Belongs to the universal ribosomal protein uS2 family
K6J81_RS08180	COG0024	Methionine aminopeptidase
K6J81_RS08185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6J81_RS08195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6J81_RS08200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6J81_RS08205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6J81_RS08210	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6J81_RS08225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6J81_RS08225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6J81_RS08230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6J81_RS08235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6J81_RS08240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6J81_RS08250	COG1073	alpha beta
K6J81_RS08255	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6J81_RS08260	COG2252	PERMEase
K6J81_RS08265	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6J81_RS08270	COG4067	protein conserved in archaea
K6J81_RS08270	COG0189	ligase activity
K6J81_RS08275	COG0189	ligase activity
K6J81_RS08285	COG0733	neurotransmitter:sodium symporter activity
K6J81_RS08290	COG3706	GGDEF domain
K6J81_RS08295	COG3328	transposase activity
K6J81_RS08320	COG1477	protein flavinylation
K6J81_RS08325	COG2871	sodium ion transport
K6J81_RS08330	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J81_RS08335	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J81_RS08340	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J81_RS08345	COG1805	sodium ion transport
K6J81_RS08350	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J81_RS08355	COG0271	Belongs to the BolA IbaG family
K6J81_RS08360	COG2813	Specifically methylates the guanine in position
K6J81_RS08370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6J81_RS08375	COG2211	Major facilitator Superfamily
K6J81_RS08385	COG1595	DNA-templated transcription, initiation
K6J81_RS08395	COG3248	Nucleoside-binding outer membrane protein
K6J81_RS08400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6J81_RS08405	COG0693	protein deglycase activity
K6J81_RS08410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6J81_RS08415	COG2166	iron-sulfur cluster assembly
K6J81_RS08420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6J81_RS08425	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6J81_RS08435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6J81_RS08435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6J81_RS08445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6J81_RS08455	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6J81_RS08470	COG3141	response to X-ray
K6J81_RS08475	COG2171	N-acyltransferase activity
K6J81_RS08485	COG0456	acetyltransferase
K6J81_RS08490	COG0189	ligase activity
K6J81_RS08490	COG0569	domain protein
K6J81_RS08505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J81_RS08510	COG1609	Transcriptional regulator
K6J81_RS08515	COG3250	beta-galactosidase activity
K6J81_RS08530	COG1022	Amp-dependent synthetase and ligase
K6J81_RS08535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6J81_RS08540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6J81_RS08550	COG0560	Phosphoserine phosphatase
K6J81_RS08560	COG0813	purine-nucleoside phosphorylase activity
K6J81_RS08565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6J81_RS08570	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6J81_RS08575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6J81_RS08585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6J81_RS08590	COG0084	hydrolase, TatD family'
K6J81_RS08600	COG3022	response to hydroperoxide
K6J81_RS08605	COG1115	amino acid carrier protein
K6J81_RS08620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6J81_RS08625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6J81_RS08630	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6J81_RS08635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6J81_RS08660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6J81_RS08670	COG0745	RESPONSE REGULATOR receiver
K6J81_RS08675	COG0784	Response regulator, receiver
K6J81_RS08675	COG2198	Histidine kinase
K6J81_RS08675	COG5002	protein histidine kinase activity
K6J81_RS08680	COG2203	Gaf domain
K6J81_RS08680	COG3706	GGDEF domain
K6J81_RS08680	COG4251	negative regulation of phosphorylation
K6J81_RS08680	COG5001	Diguanylate cyclase
K6J81_RS08685	COG1242	4 iron, 4 sulfur cluster binding
K6J81_RS08690	COG0070	glutamate synthase
K6J81_RS08690	COG0069	glutamate synthase activity
K6J81_RS08690	COG0067	glutamate synthase
K6J81_RS08700	COG0067	glutamate synthase
K6J81_RS08700	COG0069	glutamate synthase activity
K6J81_RS08700	COG0070	glutamate synthase
K6J81_RS08705	COG0493	'glutamate synthase
K6J81_RS08715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6J81_RS08725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6J81_RS08730	COG2860	membrane
K6J81_RS08735	COG0583	DNA-binding transcription factor activity
K6J81_RS08740	COG0730	response to heat
K6J81_RS08765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6J81_RS08780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6J81_RS08785	COG0494	nUDIX hydrolase
K6J81_RS08790	COG0653	protein targeting
K6J81_RS08800	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6J81_RS08805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6J81_RS08810	COG0849	cell division
K6J81_RS08815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6J81_RS08820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6J81_RS08830	COG0772	Belongs to the SEDS family
K6J81_RS08835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6J81_RS08845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6J81_RS08850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6J81_RS08855	COG0768	penicillin binding
K6J81_RS08860	COG3116	cell division
K6J81_RS08875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J81_RS08880	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6J81_RS08885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6J81_RS08890	COG2186	Transcriptional regulator
K6J81_RS08895	COG0737	Belongs to the 5'-nucleotidase family
K6J81_RS08900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6J81_RS08905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6J81_RS08910	COG4974	Belongs to the 'phage' integrase family
K6J81_RS08915	COG0716	FMN binding
K6J81_RS08935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J81_RS08940	COG1459	type II secretion system
K6J81_RS08950	COG0237	dephospho-CoA kinase activity
K6J81_RS08955	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6J81_RS08965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6J81_RS08970	COG0187	DNA topoisomerase II activity
K6J81_RS08975	COG3150	esterase
K6J81_RS08985	COG3151	Protein conserved in bacteria
K6J81_RS08990	COG0494	nUDIX hydrolase
K6J81_RS08995	COG1538	Outer membrane efflux protein
K6J81_RS09005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6J81_RS09010	COG0840	transmembrane signaling receptor activity
K6J81_RS09015	COG3025	triphosphatase activity
K6J81_RS09020	COG1392	Phosphate transport regulator
K6J81_RS09025	COG0306	phosphate transporter
K6J81_RS09030	COG4991	sh3 domain protein
K6J81_RS09040	COG3409	Peptidoglycan-binding domain 1 protein
K6J81_RS09040	COG3267	Type II secretory pathway component ExeA
K6J81_RS09050	COG0148	phosphopyruvate hydratase activity
K6J81_RS09055	COG0504	CTP synthase activity
K6J81_RS09060	COG3956	TIGRFAM MazG family protein
K6J81_RS09065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6J81_RS09080	COG5001	Diguanylate cyclase
K6J81_RS09100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6J81_RS09105	COG1381	Involved in DNA repair and RecF pathway recombination
K6J81_RS09110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6J81_RS09125	COG0481	GTPase activity
K6J81_RS09130	COG3086	response to oxidative stress
K6J81_RS09145	COG1595	DNA-templated transcription, initiation
K6J81_RS09150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6J81_RS09160	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6J81_RS09175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J81_RS09180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J81_RS09185	COG3079	Belongs to the UPF0149 family
K6J81_RS09190	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6J81_RS09200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6J81_RS09205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6J81_RS09215	COG0440	acetolactate synthase activity
K6J81_RS09220	COG0028	Belongs to the TPP enzyme family
K6J81_RS09225	COG1022	Amp-dependent synthetase and ligase
K6J81_RS09230	COG0583	DNA-binding transcription factor activity
K6J81_RS09255	COG0473	3-isopropylmalate dehydrogenase activity
K6J81_RS09260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6J81_RS09265	COG0066	3-isopropylmalate dehydratase activity
K6J81_RS09310	COG3437	response regulator, receiver
K6J81_RS09325	COG0795	lipopolysaccharide-transporting ATPase activity
K6J81_RS09330	COG0795	lipopolysaccharide-transporting ATPase activity
K6J81_RS09335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6J81_RS09340	COG2927	DNA polymerase III (CHI subunit)
K6J81_RS09345	COG0525	valine-tRNA ligase activity
K6J81_RS09350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6J81_RS09355	COG0564	pseudouridine synthase activity
K6J81_RS09365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6J81_RS09375	COG0540	Belongs to the ATCase OTCase family
K6J81_RS09385	COG0251	oxidation-reduction process
K6J81_RS09395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6J81_RS09400	COG5007	Belongs to the BolA IbaG family
K6J81_RS09410	COG2854	intermembrane phospholipid transfer
K6J81_RS09415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6J81_RS09420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6J81_RS09425	COG1127	ABC transporter
K6J81_RS09450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6J81_RS09455	COG1137	ATPase activity
K6J81_RS09465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6J81_RS09470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J81_RS09475	COG1660	Displays ATPase and GTPase activities
K6J81_RS09480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J81_RS09490	COG0312	modulator of DNA gyrase
K6J81_RS09495	COG3028	Belongs to the UPF0307 family
K6J81_RS09500	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6J81_RS09505	COG1178	ABC-type Fe3 transport system permease component
K6J81_RS09515	COG0163	prenyltransferase activity
K6J81_RS09520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6J81_RS09530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6J81_RS09535	COG2105	PFAM AIG2 family protein
K6J81_RS09545	COG0729	surface antigen
K6J81_RS09550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J81_RS09555	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6J81_RS09570	COG1136	(ABC) transporter
K6J81_RS09590	COG0529	Catalyzes the synthesis of activated sulfate
K6J81_RS09605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6J81_RS09605	COG1648	precorrin-2 dehydrogenase activity
K6J81_RS09620	COG0513	Belongs to the DEAD box helicase family
K6J81_RS09625	COG2153	protein acetylation
K6J81_RS09630	COG0697	spore germination
K6J81_RS09635	COG3061	Opacity-associated protein A
K6J81_RS09635	COG3266	domain, Protein
K6J81_RS09640	COG0545	Peptidyl-prolyl cis-trans isomerase
K6J81_RS09650	COG0203	ribosomal protein L17
K6J81_RS09655	COG0202	RNA polymerase activity
K6J81_RS09660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6J81_RS09665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6J81_RS09670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6J81_RS09675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6J81_RS09680	COG0201	protein transport
K6J81_RS09690	COG1841	ribosomal large subunit assembly
K6J81_RS09695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6J81_RS09700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6J81_RS09710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6J81_RS09715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6J81_RS09720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6J81_RS09725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6J81_RS09730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6J81_RS09735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6J81_RS09740	COG0255	Belongs to the universal ribosomal protein uL29 family
K6J81_RS09745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6J81_RS09750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6J81_RS09755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6J81_RS09760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6J81_RS09765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6J81_RS09770	COG0089	rRNA binding
K6J81_RS09775	COG0088	Forms part of the polypeptide exit tunnel
K6J81_RS09780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6J81_RS09785	COG0051	transcription antitermination factor activity, RNA binding
K6J81_RS09790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6J81_RS09795	COG0557	exoribonuclease II activity
K6J81_RS09800	COG3083	sulfuric ester hydrolase activity
K6J81_RS09805	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K6J81_RS09820	COG1047	Peptidyl-prolyl cis-trans
K6J81_RS09835	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6J81_RS09840	COG0488	(ABC) transporter
K6J81_RS09850	COG0429	hydrolase of the alpha beta-hydrolase fold
K6J81_RS09860	COG3954	Phosphoribulokinase
K6J81_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
K6J81_RS09885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6J81_RS09910	COG0180	Tryptophanyl-tRNA synthetase
K6J81_RS09915	COG0546	phosphoglycolate phosphatase activity
K6J81_RS09920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6J81_RS09925	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6J81_RS09935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6J81_RS09940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6J81_RS09970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6J81_RS09980	COG0678	peroxiredoxin activity
K6J81_RS09980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6J81_RS09985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J81_RS09995	COG0165	Argininosuccinate lyase
K6J81_RS10000	COG0137	argininosuccinate synthase activity
K6J81_RS10005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6J81_RS10010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6J81_RS10015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6J81_RS10020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6J81_RS10030	COG1045	serine acetyltransferase
K6J81_RS10035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6J81_RS10040	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6J81_RS10045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6J81_RS10050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6J81_RS10055	COG1053	succinate dehydrogenase
K6J81_RS10060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6J81_RS10065	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6J81_RS10075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6J81_RS10080	COG1509	lysine 2,3-aminomutase activity
K6J81_RS10090	COG0459	protein refolding
K6J81_RS10095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6J81_RS10120	COG0149	triose-phosphate isomerase activity
K6J81_RS10130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6J81_RS10135	COG1575	Belongs to the MenA family. Type 1 subfamily
K6J81_RS10140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6J81_RS10145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6J81_RS10150	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6J81_RS10155	COG1609	Transcriptional regulator
K6J81_RS10160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6J81_RS10170	COG0281	malic enzyme
K6J81_RS10175	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6J81_RS10180	COG0626	cystathionine gamma-synthase activity
K6J81_RS10185	COG0527	aspartate kinase activity
K6J81_RS10185	COG0460	homoserine dehydrogenase
K6J81_RS10195	COG3074	FtsZ-dependent cytokinesis
K6J81_RS10205	COG0205	6-phosphofructokinase activity
K6J81_RS10220	COG0745	RESPONSE REGULATOR receiver
K6J81_RS10225	COG2205	protein histidine kinase activity
K6J81_RS10235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6J81_RS10240	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6J81_RS10245	COG3706	GGDEF domain
K6J81_RS10250	COG1027	Aspartate ammonia-lyase
K6J81_RS10265	COG4232	protein-disulfide reductase activity
K6J81_RS10285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6J81_RS10290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6J81_RS10295	COG0194	GDP metabolic process
K6J81_RS10300	COG1758	RNA polymerase activity
K6J81_RS10310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6J81_RS10315	COG2233	PERMEase
K6J81_RS10330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6J81_RS10335	COG2183	response to ionizing radiation
K6J81_RS10345	COG0596	Alpha beta hydrolase
K6J81_RS10355	COG1040	competence protein
K6J81_RS10365	COG0494	nUDIX hydrolase
K6J81_RS10370	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6J81_RS10380	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6J81_RS10385	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6J81_RS10390	COG3156	type II secretion system protein K
K6J81_RS10395	COG4795	General secretion pathway protein
K6J81_RS10400	COG2165	general secretion pathway protein
K6J81_RS10405	COG2165	general secretion pathway protein
K6J81_RS10410	COG2165	general secretion pathway protein
K6J81_RS10415	COG1459	type II secretion system
K6J81_RS10420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J81_RS10435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6J81_RS10440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6J81_RS10445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6J81_RS10465	COG1295	ribonuclease BN
K6J81_RS10475	COG1217	gtp-binding protein TYPA
K6J81_RS10485	COG0174	glutamine synthetase
K6J81_RS10490	COG3852	Histidine kinase
K6J81_RS10505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6J81_RS10575	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6J81_RS10580	COG1404	Belongs to the peptidase S8 family
K6J81_RS10585	COG4206	TonB-dependent receptor
K6J81_RS10590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6J81_RS10605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J81_RS10610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6J81_RS10615	COG2177	Part of the ABC transporter FtsEX involved in
K6J81_RS10620	COG2884	Cell division ATP-binding protein ftsE
K6J81_RS10625	COG0552	protein localization to endoplasmic reticulum
K6J81_RS10630	COG0742	ribosomal rna small subunit methyltransferase
K6J81_RS10660	COG0783	Belongs to the Dps family
K6J81_RS10665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6J81_RS10670	COG1280	lysine exporter protein (LysE YggA)
K6J81_RS10675	COG2267	carboxylic ester hydrolase activity
K6J81_RS10680	COG0561	phosphatase activity
K6J81_RS10700	COG1011	Hydrolase
K6J81_RS10705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6J81_RS10715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K6J81_RS10720	COG0019	diaminopimelate decarboxylase activity
K6J81_RS10730	COG1965	Belongs to the frataxin family
K6J81_RS10740	COG0181	hydroxymethylbilane synthase activity
K6J81_RS10745	COG1587	Uroporphyrinogen-III synthase
K6J81_RS10750	COG2959	enzyme of heme biosynthesis
K6J81_RS10755	COG3071	HemY protein
K6J81_RS10770	COG3078	GTPase activator activity
K6J81_RS10810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6J81_RS10820	COG0840	transmembrane signaling receptor activity
K6J81_RS10825	COG1580	Controls the rotational direction of flagella during chemotaxis
K6J81_RS10830	COG3161	chorismate lyase activity
K6J81_RS10835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6J81_RS10845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6J81_RS10855	COG0534	Mate efflux family protein
K6J81_RS10860	COG1858	cytochrome C peroxidase
K6J81_RS10865	COG0805	protein transport
K6J81_RS10870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6J81_RS10875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6J81_RS10890	COG2226	methyltransferase
K6J81_RS10895	COG1322	Protein conserved in bacteria
K6J81_RS10905	COG2081	HI0933 family
K6J81_RS10915	COG1528	Iron-storage protein
K6J81_RS10920	COG0589	response to stress
K6J81_RS10940	COG5001	Diguanylate cyclase
K6J81_RS10940	COG5002	protein histidine kinase activity
K6J81_RS10945	COG1522	sequence-specific DNA binding
K6J81_RS10965	COG0006	proline dipeptidase activity
K6J81_RS10965	COG0006	proline dipeptidase activity
K6J81_RS10970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6J81_RS10975	COG2022	thiamine diphosphate biosynthetic process
K6J81_RS10980	COG2104	thiamine diphosphate biosynthetic process
K6J81_RS10985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6J81_RS10995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6J81_RS11000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6J81_RS11040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6J81_RS11050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6J81_RS11055	COG0408	coproporphyrinogen oxidase activity
K6J81_RS11060	COG0009	L-threonylcarbamoyladenylate synthase
K6J81_RS11065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6J81_RS11070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6J81_RS11075	COG0551	DNA topoisomerase type I activity
K6J81_RS11080	COG2922	Belongs to the Smg family
K6J81_RS11085	COG0758	DNA mediated transformation
K6J81_RS11090	COG1652	LysM domain
K6J81_RS11095	COG0242	peptide deformylase activity
K6J81_RS11100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6J81_RS11105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6J81_RS11105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6J81_RS11110	COG0569	domain protein
K6J81_RS11125	COG1272	protein, Hemolysin III
K6J81_RS11130	COG4326	sporulation control protein
K6J81_RS11135	COG3084	Protein conserved in bacteria
K6J81_RS11145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6J81_RS11150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6J81_RS11155	COG0204	Acyl-transferase
K6J81_RS11160	COG0606	chelatase, subunit chli
K6J81_RS11175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6J81_RS11180	COG0129	dihydroxy-acid dehydratase activity
K6J81_RS11190	COG0604	alcohol dehydrogenase
K6J81_RS11200	COG0425	Belongs to the sulfur carrier protein TusA family
K6J81_RS11210	COG2119	membrane
K6J81_RS11215	COG0752	glycyl-tRNA synthetase alpha subunit
K6J81_RS11220	COG0751	glycine-tRNA ligase activity
K6J81_RS11230	COG0071	Belongs to the small heat shock protein (HSP20) family
K6J81_RS11240	COG0187	DNA topoisomerase II activity
K6J81_RS11245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6J81_RS11250	COG0592	DNA-directed DNA polymerase activity
K6J81_RS11255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6J81_RS11270	COG1126	abc transporter atp-binding protein
K6J81_RS11275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6J81_RS11280	COG0594	ribonuclease P activity
K6J81_RS11290	COG0706	membrane insertase activity
K6J81_RS11295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6J81_RS11300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6J81_RS11305	COG0445	tRNA wobble uridine modification
K6J81_RS11315	COG1192	Involved in chromosome partitioning
K6J81_RS11320	COG1475	DNA binding
K6J81_RS11325	COG3312	ion transport
K6J81_RS11330	COG0356	it plays a direct role in the translocation of protons across the membrane
K6J81_RS11340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6J81_RS11345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6J81_RS11350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6J81_RS11355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6J81_RS11360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6J81_RS11370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6J81_RS11375	COG2814	Major facilitator Superfamily
K6J81_RS11380	COG0583	DNA-binding transcription factor activity
K6J81_RS11385	COG0183	Belongs to the thiolase family
K6J81_RS11400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6J81_RS11405	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
K6J81_RS11450	COG0583	DNA-binding transcription factor activity
K6J81_RS11455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6J81_RS11460	COG2960	long-chain fatty acid transporting porin activity
K6J81_RS11465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6J81_RS11470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J81_RS11475	COG1309	transcriptional regulator
K6J81_RS11525	COG0747	negative chemotaxis
K6J81_RS11530	COG0601	transmembrane transport
K6J81_RS11535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J81_RS11545	COG2131	deaminase
K6J81_RS11570	COG3621	Patatin-like phospholipase
K6J81_RS11610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J81_RS11615	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6J81_RS11625	COG0210	DNA helicase
K6J81_RS11630	COG1280	lysine exporter protein (LysE YggA)
K6J81_RS11650	COG0514	ATP-dependent DNA helicase (RecQ)
K6J81_RS11665	COG1132	(ABC) transporter
K6J81_RS11670	COG4774	siderophore transport
K6J81_RS11675	COG1120	ATPase activity
K6J81_RS11695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6J81_RS11705	COG2862	Uncharacterized protein family, UPF0114
K6J81_RS11710	COG1561	YicC-like family, N-terminal region
K6J81_RS11715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6J81_RS11720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6J81_RS11725	COG1560	Kdo2-lipid A biosynthetic process
K6J81_RS11730	COG1560	Kdo2-lipid A biosynthetic process
K6J81_RS11735	COG1309	transcriptional regulator
K6J81_RS11745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6J81_RS11755	COG2003	Belongs to the UPF0758 family
K6J81_RS11760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6J81_RS11765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6J81_RS11775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6J81_RS11780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6J81_RS11785	COG0859	PFAM glycosyl transferase family 9
K6J81_RS11790	COG0463	Glycosyl transferase, family 2
K6J81_RS11795	COG0859	PFAM glycosyl transferase family 9
K6J81_RS11800	COG3642	lipopolysaccharide core region biosynthetic process
K6J81_RS11830	COG1519	Transferase
K6J81_RS11865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6J81_RS11870	COG0662	Cupin 2, conserved barrel domain protein
K6J81_RS11870	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K6J81_RS11875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6J81_RS11880	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6J81_RS11910	COG0318	PFAM AMP-dependent synthetase and ligase
K6J81_RS11915	COG1454	alcohol dehydrogenase
K6J81_RS11915	COG1012	belongs to the aldehyde dehydrogenase family
K6J81_RS11960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6J81_RS11965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K6J81_RS11970	COG0668	transmembrane transport
K6J81_RS11975	COG1573	uracil-dna glycosylase
K6J81_RS11985	COG3068	Protein conserved in bacteria
K6J81_RS11995	COG1940	carbohydrate kinase activity
K6J81_RS12000	COG1253	flavin adenine dinucleotide binding
K6J81_RS12005	COG0776	regulation of translation
K6J81_RS12015	COG0151	Belongs to the GarS family
K6J81_RS12030	COG0789	Transcriptional regulator
K6J81_RS12035	COG3710	Transcriptional regulator
K6J81_RS12040	COG0531	amino acid
K6J81_RS12045	COG1982	Orn Lys Arg decarboxylase major
K6J81_RS12050	COG0840	transmembrane signaling receptor activity
K6J81_RS12065	COG0800	Aldolase
K6J81_RS12075	COG3265	gluconokinase activity
K6J81_RS12080	COG0129	dihydroxy-acid dehydratase activity
K6J81_RS12085	COG1609	Transcriptional regulator
K6J81_RS12090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6J81_RS12095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6J81_RS12100	COG2264	protein methyltransferase activity
K6J81_RS12105	COG0439	Biotin carboxylase
K6J81_RS12110	COG0511	ligase activity, forming carbon-carbon bonds
K6J81_RS12115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6J81_RS12135	COG2814	Major facilitator Superfamily
K6J81_RS12140	COG0784	Response regulator, receiver
K6J81_RS12140	COG2205	protein histidine kinase activity
K6J81_RS12145	COG0248	Ppx GppA phosphatase
K6J81_RS12150	COG0513	Belongs to the DEAD box helicase family
K6J81_RS12155	COG3118	belongs to the thioredoxin family
K6J81_RS12170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6J81_RS12215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6J81_RS12225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6J81_RS12235	COG1072	(Pantothenic acid kinase))
K6J81_RS12260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6J81_RS12265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6J81_RS12270	COG0250	Participates in transcription elongation, termination and antitermination
K6J81_RS12275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6J81_RS12285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6J81_RS12290	COG0222	ribosome binding
K6J81_RS12295	COG0085	RNA polymerase activity
K6J81_RS12300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6J81_RS12305	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6J81_RS12310	COG2816	NAD+ diphosphatase activity
K6J81_RS12315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6J81_RS12330	COG4942	peptidase
K6J81_RS12335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6J81_RS12345	COG0471	metal ion transport
K6J81_RS12350	COG0688	phosphatidylethanolamine metabolic process
K6J81_RS12355	COG1162	GTPase activity
K6J81_RS12360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6J81_RS12405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6J81_RS12410	COG0802	atpase or kinase
K6J81_RS12420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6J81_RS12425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6J81_RS12430	COG1923	regulation of RNA biosynthetic process
K6J81_RS12435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6J81_RS12440	COG0330	HflC and HflK could
K6J81_RS12445	COG0330	HflC and HflK could
K6J81_RS12450	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K6J81_RS12455	COG2900	Belongs to the SlyX family
K6J81_RS12465	COG0545	Peptidyl-prolyl cis-trans isomerase
K6J81_RS12470	COG2964	Protein conserved in bacteria
K6J81_RS12475	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6J81_RS12480	COG2923	Belongs to the DsrF TusC family
K6J81_RS12495	COG0049	tRNA binding
K6J81_RS12500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6J81_RS12505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6J81_RS12510	COG2906	2 iron, 2 sulfur cluster binding
K6J81_RS12520	COG0360	Binds together with S18 to 16S ribosomal RNA
K6J81_RS12525	COG2965	DNA replication, synthesis of RNA primer
K6J81_RS12530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6J81_RS12535	COG0359	binds to the 23S rRNA
K6J81_RS12550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6J81_RS12555	COG0432	Pfam Uncharacterised protein family UPF0047
K6J81_RS12575	COG0735	belongs to the Fur family
K6J81_RS12580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6J81_RS12605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6J81_RS12615	COG0175	sulfate reduction
K6J81_RS12685	COG0646	methionine synthase
K6J81_RS12685	COG1410	methionine synthase
K6J81_RS12690	COG0527	aspartate kinase activity
K6J81_RS12695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6J81_RS12705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6J81_RS12720	COG0629	single-stranded DNA binding
K6J81_RS12725	COG2199	diguanylate cyclase activity
K6J81_RS12725	COG2200	EAL domain
K6J81_RS12750	COG3409	Peptidoglycan-binding domain 1 protein
K6J81_RS12750	COG3267	Type II secretory pathway component ExeA
K6J81_RS12760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J81_RS12765	COG1459	type II secretion system
K6J81_RS12775	COG2165	general secretion pathway protein
K6J81_RS12780	COG2165	general secretion pathway protein
K6J81_RS12810	COG1077	Cell shape determining protein MreB Mrl
K6J81_RS12815	COG1792	Involved in formation and maintenance of cell shape
K6J81_RS12820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6J81_RS12825	COG0424	maF-like protein
K6J81_RS12840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6J81_RS12845	COG0312	modulator of DNA gyrase
K6J81_RS12855	COG2235	arginine
K6J81_RS12875	COG0589	response to stress
K6J81_RS12885	COG2358	TRAP transporter, solute receptor (TAXI family
K6J81_RS12890	COG1438	arginine binding
K6J81_RS12895	COG0039	L-malate dehydrogenase activity
K6J81_RS12910	COG0142	geranyltranstransferase activity
K6J81_RS12915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6J81_RS12920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6J81_RS12930	COG2966	Psort location CytoplasmicMembrane, score
K6J81_RS12935	COG3610	response to peptide
K6J81_RS12945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6J81_RS12950	COG2967	ApaG domain
K6J81_RS12955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6J81_RS12965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6J81_RS12970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6J81_RS12975	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6J81_RS13030	COG0741	lytic transglycosylase activity
K6J81_RS13035	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K6J81_RS13040	COG1194	a g-specific adenine glycosylase
K6J81_RS13050	COG2066	Belongs to the glutaminase family
K6J81_RS13055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6J81_RS13060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6J81_RS13070	COG1872	DUF167
K6J81_RS13075	COG0762	integral membrane protein
K6J81_RS13080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6J81_RS13085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6J81_RS13105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6J81_RS13110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6J81_RS13115	COG1678	Uncharacterized ACR, COG1678
K6J81_RS13120	COG0189	ligase activity
K6J81_RS13125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6J81_RS13130	COG2356	endonuclease I
K6J81_RS13140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6J81_RS13145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6J81_RS13150	COG0583	DNA-binding transcription factor activity
K6J81_RS13155	COG4771	TonB-dependent receptor
K6J81_RS13160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6J81_RS13165	COG0126	phosphoglycerate kinase activity
K6J81_RS13170	COG0191	fructose-bisphosphate aldolase activity
K6J81_RS13175	COG0668	transmembrane transport
K6J81_RS13180	COG1279	arginine transmembrane transporter activity
K6J81_RS13200	COG1349	DNA-binding transcription factor activity
K6J81_RS13205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6J81_RS13210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6J81_RS13260	COG4969	Belongs to the N-Me-Phe pilin family
K6J81_RS13270	COG0739	heme binding
K6J81_RS13300	COG2003	Belongs to the UPF0758 family
K6J81_RS13310	COG0840	transmembrane signaling receptor activity
K6J81_RS13315	COG2207	Transcriptional regulator
K6J81_RS13320	COG0840	transmembrane signaling receptor activity
K6J81_RS13325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6J81_RS13330	COG0582	viral genome integration into host DNA
K6J81_RS13345	COG0358	DNA primase activity
K6J81_RS13350	COG1610	YqeY-like protein
K6J81_RS13355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6J81_RS13360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6J81_RS13370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6J81_RS13375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6J81_RS13380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6J81_RS13385	COG1968	undecaprenyl-diphosphatase activity
K6J81_RS13390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6J81_RS13395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6J81_RS13400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6J81_RS13405	COG0585	pseudouridine synthase activity
K6J81_RS13410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6J81_RS13415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6J81_RS13425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6J81_RS13430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6J81_RS13450	COG4208	sulfate ABC transporter
K6J81_RS13455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K6J81_RS13465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6J81_RS13475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6J81_RS13480	COG0527	aspartate kinase activity
K6J81_RS13485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K6J81_RS13530	COG3630	sodium ion export across plasma membrane
K6J81_RS13535	COG5016	pyruvate
K6J81_RS13535	COG0511	ligase activity, forming carbon-carbon bonds
K6J81_RS13540	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6J81_RS13550	COG1238	metal cluster binding
K6J81_RS13555	COG0612	Peptidase, M16
K6J81_RS13560	COG2918	glutathione biosynthetic process
K6J81_RS13565	COG1854	S-ribosylhomocysteine lyase activity
K6J81_RS13570	COG4536	flavin adenine dinucleotide binding
K6J81_RS13575	COG4137	Cytochrome C assembly protein
K6J81_RS13580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6J81_RS13585	COG0228	four-way junction DNA binding
K6J81_RS13590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6J81_RS13595	COG0336	Belongs to the RNA methyltransferase TrmD family
K6J81_RS13600	COG0335	large ribosomal subunit rRNA binding
K6J81_RS13605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6J81_RS13610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6J81_RS13620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6J81_RS13625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6J81_RS13630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6J81_RS13635	COG0723	plastoquinol--plastocyanin reductase activity
K6J81_RS13640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6J81_RS13645	COG2857	Cytochrome c1
K6J81_RS13650	COG0625	glutathione transferase activity
K6J81_RS13655	COG2969	positive regulation of protein catabolic process
K6J81_RS13660	COG2823	Periplasmic or secreted lipoprotein
K6J81_RS13665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6J81_RS13670	COG0792	nuclease activity
K6J81_RS13675	COG3107	peptidoglycan biosynthetic process
K6J81_RS13680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6J81_RS13695	COG0288	reversible hydration of carbon dioxide
K6J81_RS13700	COG0659	secondary active sulfate transmembrane transporter activity
K6J81_RS13705	COG1131	(ABC) transporter
K6J81_RS13710	COG0842	Transport permease protein
K6J81_RS13715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6J81_RS13720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6J81_RS13725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6J81_RS13735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6J81_RS13745	COG1489	DNA binding
K6J81_RS13760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6J81_RS13765	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6J81_RS13770	COG1049	propionate catabolic process, 2-methylcitrate cycle
K6J81_RS13775	COG3112	Uncharacterised protein family (UPF0231)
K6J81_RS13780	COG0347	Belongs to the P(II) protein family
K6J81_RS13785	COG0004	ammonium transporteR
K6J81_RS13790	COG1840	ABC-type Fe3 transport system, periplasmic component
K6J81_RS13820	COG2971	BadF BadG BcrA BcrD
K6J81_RS13830	COG4608	Belongs to the ABC transporter superfamily
K6J81_RS13835	COG0444	Belongs to the ABC transporter superfamily
K6J81_RS13840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J81_RS13845	COG0601	transmembrane transport
K6J81_RS13850	COG0747	negative chemotaxis
K6J81_RS13855	COG0784	Response regulator, receiver
K6J81_RS13855	COG2205	protein histidine kinase activity
K6J81_RS13865	COG0628	permease
K6J81_RS13870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6J81_RS13875	COG0316	Belongs to the HesB IscA family
K6J81_RS13895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6J81_RS13900	COG2027	D-alanyl-D-alanine carboxypeptidase
K6J81_RS13905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6J81_RS13910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6J81_RS13915	COG1534	Rna-binding protein
K6J81_RS13920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6J81_RS13925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6J81_RS13930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6J81_RS13940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6J81_RS13955	COG0779	Required for maturation of 30S ribosomal subunits
K6J81_RS13960	COG0195	Participates in both transcription termination and antitermination
K6J81_RS13965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6J81_RS13970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6J81_RS13980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6J81_RS14005	COG0826	peptidase U32
K6J81_RS14010	COG0826	peptidase U32
K6J81_RS14020	COG3154	lipid carrier protein
K6J81_RS14025	COG3153	acetyltransferase
K6J81_RS14115	COG1357	PFAM Pentapeptide repeats (8 copies)
K6J81_RS14140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6J81_RS14155	COG3074	FtsZ-dependent cytokinesis
K6J81_RS14160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6J81_RS14180	COG0281	malic enzyme
K6J81_RS14185	COG0254	rRNA binding
K6J81_RS14200	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6J81_RS14225	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6J81_RS14230	COG0471	metal ion transport
K6J81_RS14260	COG4104	PAAR repeat-containing protein
K6J81_RS14265	COG3501	Rhs element vgr protein
K6J81_RS14275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6J81_RS14280	COG1640	4-alpha-glucanotransferase
K6J81_RS14285	COG0058	SHG alpha-glucan phosphorylase activity
K6J81_RS14290	COG2909	trisaccharide binding
K6J81_RS14305	COG2084	Dehydrogenase
K6J81_RS14310	COG0217	transcriptional regulatory protein
K6J81_RS14350	COG1444	tRNA N-acetyltransferase activity
K6J81_RS14385	COG0642	Histidine kinase
K6J81_RS14390	COG2194	sulfuric ester hydrolase activity
K6J81_RS14400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J81_RS14405	COG0601	transmembrane transport
K6J81_RS14425	COG0643	Histidine kinase
K6J81_RS14425	COG2198	Histidine kinase
K6J81_RS14430	COG0835	chemotaxis
K6J81_RS14435	COG0835	chemotaxis
K6J81_RS14440	COG0840	transmembrane signaling receptor activity
K6J81_RS14445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6J81_RS14470	COG0745	RESPONSE REGULATOR receiver
K6J81_RS14510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6J81_RS14535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6J81_RS14570	COG0531	amino acid
K6J81_RS14585	COG1901	pseudouridine methyltransferase
K6J81_RS14595	COG4221	oxidoreductase activity
K6J81_RS14600	COG0840	transmembrane signaling receptor activity
K6J81_RS14610	COG2910	NAD(P)H-binding
K6J81_RS14640	COG0673	inositol 2-dehydrogenase activity
K6J81_RS14645	COG3722	fumarate hydratase activity
K6J81_RS14650	COG0246	Mannitol dehydrogenase
K6J81_RS14655	COG2213	PTS system mannitol-specific
K6J81_RS14655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J81_RS14660	COG0739	heme binding
K6J81_RS14670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6J81_RS14675	COG4597	amino acid ABC transporter
K6J81_RS14680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J81_RS14690	COG1126	abc transporter atp-binding protein
K6J81_RS14695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6J81_RS14705	COG0840	transmembrane signaling receptor activity
K6J81_RS14720	COG0840	transmembrane signaling receptor activity
K6J81_RS14735	COG4580	involved in the transport of maltose and maltodextrins
K6J81_RS14750	COG0363	glucosamine-6-phosphate deaminase activity
K6J81_RS14775	COG2259	Doxx family
K6J81_RS14780	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K6J81_RS14785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6J81_RS14795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6J81_RS14800	COG3366	ferrous iron transmembrane transporter activity
K6J81_RS14805	COG0700	Nucleoside recognition
K6J81_RS14815	COG0697	spore germination
K6J81_RS14820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6J81_RS14825	COG1764	response to oxidative stress
K6J81_RS14830	COG1846	Transcriptional regulator
K6J81_RS14850	COG2207	Transcriptional regulator
K6J81_RS14855	COG1280	lysine exporter protein (LysE YggA)
K6J81_RS14865	COG1902	pentaerythritol trinitrate reductase activity
K6J81_RS14875	COG1132	(ABC) transporter
K6J81_RS14885	COG1902	pentaerythritol trinitrate reductase activity
K6J81_RS14895	COG0583	DNA-binding transcription factor activity
K6J81_RS14900	COG0513	Belongs to the DEAD box helicase family
K6J81_RS14910	COG0840	transmembrane signaling receptor activity
K6J81_RS14920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6J81_RS14935	COG1620	l-lactate permease
K6J81_RS14945	COG0583	DNA-binding transcription factor activity
K6J81_RS14970	COG4172	Belongs to the ABC transporter superfamily
K6J81_RS14980	COG1067	ATP-dependent peptidase activity
K6J81_RS14985	COG0840	transmembrane signaling receptor activity
K6J81_RS14990	COG2211	Major facilitator Superfamily
K6J81_RS15000	COG3123	guanosine phosphorylase activity
K6J81_RS15005	COG1741	Belongs to the pirin family
K6J81_RS15015	COG5001	Diguanylate cyclase
K6J81_RS15020	COG0583	DNA-binding transcription factor activity
K6J81_RS15055	COG3706	GGDEF domain
K6J81_RS15060	COG1846	Transcriptional regulator
K6J81_RS15065	COG0835	chemotaxis
K6J81_RS15065	COG0784	Response regulator, receiver
K6J81_RS15070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6J81_RS15080	COG0393	Putative heavy-metal-binding
K6J81_RS15095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J81_RS15100	COG3842	ATPase activity
K6J81_RS15110	COG1175	transmembrane transport
K6J81_RS15115	COG3833	ABC-type maltose transport systems, permease component
K6J81_RS15130	COG1349	DNA-binding transcription factor activity
K6J81_RS15135	COG2199	diguanylate cyclase activity
K6J81_RS15160	COG1278	Cold shock
K6J81_RS15165	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6J81_RS15170	COG2354	Protein conserved in bacteria
K6J81_RS15175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6J81_RS15185	COG3152	Membrane
K6J81_RS15195	COG0418	dihydroorotase activity
K6J81_RS15200	COG3217	Mosc domain protein beta barrel domain protein
K6J81_RS15200	COG3217	Mosc domain protein beta barrel domain protein
K6J81_RS15200	COG0633	Ferredoxin
K6J81_RS15200	COG0633	Ferredoxin
K6J81_RS15235	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6J81_RS15240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J81_RS15245	COG4558	Periplasmic binding protein
K6J81_RS15250	COG0848	biopolymer transport protein
K6J81_RS15255	COG0811	peptide transport
K6J81_RS15260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6J81_RS15270	COG3721	Heme iron utilization protein
K6J81_RS15275	COG0748	coenzyme F420 binding
K6J81_RS15285	COG3835	regulator
K6J81_RS15290	COG2610	gluconate transmembrane transporter activity
K6J81_RS15320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6J81_RS15325	COG0363	glucosamine-6-phosphate deaminase activity
K6J81_RS15330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6J81_RS15335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6J81_RS15340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6J81_RS15360	COG0346	lactoylglutathione lyase activity
K6J81_RS15385	COG1063	alcohol dehydrogenase
K6J81_RS15430	COG0583	DNA-binding transcription factor activity
K6J81_RS15435	COG3048	D-serine ammonia-lyase activity
K6J81_RS15450	COG1294	oxidase, subunit
K6J81_RS15455	COG1271	oxidase subunit
K6J81_RS15460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6J81_RS15465	COG1686	Belongs to the peptidase S11 family
K6J81_RS15475	COG3047	cAMP biosynthetic process
K6J81_RS15485	COG3227	Zinc metalloprotease (Elastase)
K6J81_RS15495	COG2267	carboxylic ester hydrolase activity
K6J81_RS15500	COG2067	long-chain fatty acid transport protein
K6J81_RS15510	COG0366	Alpha amylase catalytic
K6J81_RS15515	COG4989	oxidoreductase activity
K6J81_RS15525	COG1136	(ABC) transporter
K6J81_RS15530	COG0577	efflux transmembrane transporter activity
K6J81_RS15530	COG1136	(ABC) transporter
K6J81_RS15545	COG3275	phosphorelay sensor kinase activity
K6J81_RS15550	COG3279	Response regulator of the LytR AlgR family
K6J81_RS15590	COG1765	OsmC-like protein
K6J81_RS15595	COG1253	flavin adenine dinucleotide binding
K6J81_RS15620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6J81_RS15635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6J81_RS15640	COG3186	Phenylalanine-4-hydroxylase
K6J81_RS15650	COG0456	acetyltransferase
K6J81_RS15655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6J81_RS15660	COG0662	Cupin 2, conserved barrel domain protein
K6J81_RS15665	COG0527	aspartate kinase activity
K6J81_RS15675	COG0459	protein refolding
K6J81_RS15680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6J81_RS15685	COG2239	Acts as a magnesium transporter
K6J81_RS15695	COG1166	arginine decarboxylase activity
K6J81_RS15700	COG0010	Belongs to the arginase family
K6J81_RS15710	COG3227	Zinc metalloprotease (Elastase)
K6J81_RS15715	COG3397	chitin binding
K6J81_RS15720	COG3046	protein related to deoxyribodipyrimidine photolyase
K6J81_RS15730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6J81_RS15745	COG0513	Belongs to the DEAD box helicase family
K6J81_RS15755	COG1368	sulfuric ester hydrolase activity
K6J81_RS15760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J81_RS15815	COG0484	heat shock protein binding
K6J81_RS15825	COG1716	ATPase activity
K6J81_RS15825	COG5001	Diguanylate cyclase
K6J81_RS15830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6J81_RS15840	COG4181	ATPase activity
K6J81_RS15845	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6J81_RS15860	COG1984	allophanate hydrolase subunit 2
K6J81_RS15870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6J81_RS15875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6J81_RS15880	COG0840	transmembrane signaling receptor activity
K6J81_RS15885	COG0814	amino acid
K6J81_RS15890	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K6J81_RS15895	COG0513	Belongs to the DEAD box helicase family
K6J81_RS15900	COG1309	transcriptional regulator
K6J81_RS15910	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K6J81_RS15915	COG0494	nUDIX hydrolase
K6J81_RS15925	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6J81_RS15935	COG1126	abc transporter atp-binding protein
K6J81_RS15940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J81_RS15945	COG4215	(ABC) transporter
K6J81_RS15950	COG4160	amino acid transport
K6J81_RS15955	COG0583	DNA-binding transcription factor activity
K6J81_RS15985	COG3118	belongs to the thioredoxin family
K6J81_RS15990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6J81_RS16000	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
K6J81_RS16005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6J81_RS16010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6J81_RS16015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6J81_RS16025	COG2926	Belongs to the UPF0265 family
K6J81_RS16040	COG2827	Endonuclease containing a URI domain
K6J81_RS16050	COG1879	ABC-type sugar transport system periplasmic component
K6J81_RS16055	COG5002	protein histidine kinase activity
K6J81_RS16055	COG0784	Response regulator, receiver
K6J81_RS16100	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6J81_RS16105	COG4149	molybdate abc transporter
K6J81_RS16110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6J81_RS16140	COG1289	transmembrane transporter activity
K6J81_RS16145	COG0210	DNA helicase
K6J81_RS16160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6J81_RS16165	COG1335	isochorismatase
K6J81_RS16170	COG1803	Methylglyoxal synthase
K6J81_RS16175	COG1879	ABC-type sugar transport system periplasmic component
K6J81_RS16180	COG0784	Response regulator, receiver
K6J81_RS16180	COG2205	protein histidine kinase activity
K6J81_RS16180	COG2198	Histidine kinase
K6J81_RS16185	COG0469	pyruvate kinase activity
K6J81_RS16190	COG2271	Major facilitator Superfamily
K6J81_RS16200	COG4191	Histidine kinase
K6J81_RS16215	COG1979	alcohol dehydrogenase
K6J81_RS16225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6J81_RS16245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J81_RS16250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J81_RS16260	COG0183	Belongs to the thiolase family
K6J81_RS16270	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6J81_RS16275	COG3842	ATPase activity
K6J81_RS16285	COG1840	ABC-type Fe3 transport system, periplasmic component
K6J81_RS16295	COG3851	Histidine kinase
K6J81_RS16300	COG2197	response regulator
K6J81_RS16305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6J81_RS16325	COG0243	molybdopterin cofactor binding
K6J81_RS16335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6J81_RS16340	COG3850	Histidine kinase
K6J81_RS16345	COG2197	response regulator
K6J81_RS16350	COG1609	Transcriptional regulator
K6J81_RS16370	COG1760	l-serine dehydratase
K6J81_RS16375	COG3069	C4-dicarboxylate transmembrane transporter activity
K6J81_RS16380	COG0840	transmembrane signaling receptor activity
K6J81_RS16385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6J81_RS16390	COG0545	Peptidyl-prolyl cis-trans isomerase
K6J81_RS16395	COG2885	chlorophyll binding
K6J81_RS16405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6J81_RS16410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J81_RS16415	COG1621	beta-fructofuranosidase activity
K6J81_RS16420	COG1609	Transcriptional regulator
K6J81_RS16425	COG1263	PTS System
K6J81_RS16425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J81_RS16470	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6J81_RS16510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6J81_RS16540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6J81_RS16575	COG2897	thiosulfate sulfurtransferase activity
K6J81_RS16585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6J81_RS16595	COG0302	gtp cyclohydrolase
K6J81_RS16600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J81_RS16600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J81_RS16605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6J81_RS16610	COG1970	mechanosensitive ion channel activity
K6J81_RS16615	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6J81_RS16625	COG1011	Hydrolase
K6J81_RS16630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6J81_RS16635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6J81_RS16640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6J81_RS16645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6J81_RS16655	COG3842	ATPase activity
K6J81_RS16675	COG3104	oligopeptide transport
K6J81_RS16700	COG4166	transmembrane transport
K6J81_RS16705	COG4174	ABC transporter (Permease)
K6J81_RS16710	COG4239	(ABC) transporter, permease
K6J81_RS16715	COG4172	Belongs to the ABC transporter superfamily
K6J81_RS16720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6J81_RS16735	COG0625	glutathione transferase activity
K6J81_RS16755	COG2050	protein possibly involved in aromatic compounds catabolism
K6J81_RS16770	COG1629	transport
K6J81_RS16770	COG4771	TonB-dependent receptor
K6J81_RS16775	COG0583	DNA-binding transcription factor activity
K6J81_RS16780	COG0045	succinate-CoA ligase (ADP-forming) activity
K6J81_RS16780	COG1042	CoA-binding domain protein
K6J81_RS16780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J81_RS16800	COG0023	Translation Initiation Factor
K6J81_RS16805	COG3140	Belongs to the UPF0181 family
K6J81_RS16830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6J81_RS16835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6J81_RS16850	COG3706	GGDEF domain
K6J81_RS16870	COG2199	diguanylate cyclase activity
K6J81_RS16900	COG2824	Alkylphosphonate utilization operon protein PhnA
K6J81_RS16920	COG0583	DNA-binding transcription factor activity
K6J81_RS16925	COG2116	formate transmembrane transporter activity
K6J81_RS16935	COG3038	cytochrome b561
K6J81_RS16945	COG2200	EAL domain
K6J81_RS16955	COG0586	Pfam SNARE associated Golgi protein
K6J81_RS16960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6J81_RS16965	COG0745	RESPONSE REGULATOR receiver
K6J81_RS16970	COG2205	protein histidine kinase activity
K6J81_RS16975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6J81_RS16975	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6J81_RS16975	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6J81_RS16975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6J81_RS16990	COG0523	cobalamin synthesis protein
K6J81_RS17005	COG0156	8-amino-7-oxononanoate synthase activity
K6J81_RS17010	COG2205	protein histidine kinase activity
K6J81_RS17010	COG0784	Response regulator, receiver
K6J81_RS17015	COG0419	ATPase involved in DNA repair
K6J81_RS17020	COG0420	3'-5' exonuclease activity
K6J81_RS17025	COG1609	Transcriptional regulator
K6J81_RS17030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J81_RS17030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J81_RS17035	COG1105	Belongs to the carbohydrate kinase PfkB family
K6J81_RS17045	COG0189	ligase activity
K6J81_RS17045	COG4067	protein conserved in archaea
K6J81_RS17055	COG0602	queuosine metabolic process
K6J81_RS17075	COG0346	lactoylglutathione lyase activity
K6J81_RS17220	COG0346	lactoylglutathione lyase activity
K6J81_RS17240	COG3039	Transposase
K6J81_RS17255	COG2944	sequence-specific DNA binding
K6J81_RS17260	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
K6J81_RS17335	COG4977	sequence-specific DNA binding
K6J81_RS17400	COG3040	lipid binding
K6J81_RS17420	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6J81_RS17435	COG3093	addiction module antidote protein HigA
K6J81_RS17440	COG3549	Plasmid maintenance system killer
K6J81_RS17635	COG1280	lysine exporter protein (LysE YggA)
K6J81_RS17645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6J81_RS17660	COG3040	lipid binding
K6J81_RS17675	COG0346	lactoylglutathione lyase activity
K6J81_RS17725	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6J81_RS17795	COG3041	Addiction module toxin RelE StbE family
K6J81_RS17825	COG3040	lipid binding
K6J81_RS17830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J81_RS17845	COG0494	nUDIX hydrolase
K6J81_RS17870	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6J81_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
K6J81_RS17950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6J81_RS17955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6J81_RS17990	COG3039	Transposase
K6J81_RS18000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6J81_RS18010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6J81_RS18015	COG0509	glycine decarboxylation via glycine cleavage system
K6J81_RS18020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6J81_RS18020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6J81_RS18045	COG1686	Belongs to the peptidase S11 family
K6J81_RS18060	COG2814	Major facilitator Superfamily
K6J81_RS18075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6J81_RS18100	COG5002	protein histidine kinase activity
K6J81_RS18105	COG0745	RESPONSE REGULATOR receiver
K6J81_RS18130	COG0366	Alpha amylase catalytic
K6J81_RS18135	COG3038	cytochrome b561
K6J81_RS18165	COG0561	phosphatase activity
K6J81_RS18170	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K6J81_RS18175	COG3623	hexulose-6-phosphate isomerase
K6J81_RS18185	COG0745	RESPONSE REGULATOR receiver
K6J81_RS18205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6J81_RS18220	COG2207	Transcriptional regulator
K6J81_RS18225	COG4604	ABC transporter, ATP-binding protein
K6J81_RS18230	COG4605	iron ion homeostasis
K6J81_RS18235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J81_RS18260	COG5380	lipid catabolic process
K6J81_RS18265	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6J81_RS18270	COG0840	transmembrane signaling receptor activity
K6J81_RS18280	COG3240	lipase activity
K6J81_RS18285	COG3706	GGDEF domain
K6J81_RS18295	COG2814	Major facilitator Superfamily
K6J81_RS18310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J81_RS18310	COG4191	Histidine kinase
K6J81_RS18315	COG0784	Response regulator, receiver
K6J81_RS18315	COG3437	response regulator, receiver
K6J81_RS18320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6J81_RS18325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6J81_RS18330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6J81_RS18335	COG0513	Belongs to the DEAD box helicase family
K6J81_RS18380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6J81_RS18390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6J81_RS18395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6J81_RS18395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6J81_RS18420	COG3036	rescue of stalled ribosome
K6J81_RS18425	COG1278	Cold shock
K6J81_RS18430	COG1017	nitric oxide dioxygenase activity
K6J81_RS18430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6J81_RS18435	COG3604	Transcriptional regulator
K6J81_RS18445	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6J81_RS18450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6J81_RS18465	COG0840	transmembrane signaling receptor activity
K6J81_RS18470	COG0714	Associated with various cellular activities
K6J81_RS18490	COG2304	oxidoreductase activity
K6J81_RS18505	COG1278	Cold shock
K6J81_RS18510	COG5002	protein histidine kinase activity
K6J81_RS18510	COG5001	Diguanylate cyclase
K6J81_RS18520	COG3530	Putative quorum-sensing-regulated virulence factor
K6J81_RS18535	COG0814	amino acid
K6J81_RS18540	COG0589	response to stress
K6J81_RS18550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6J81_RS18550	COG2111	Na H antiporter
K6J81_RS18555	COG2111	Na H antiporter
K6J81_RS18555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6J81_RS18560	COG1006	Multisubunit Na H antiporter MnhC subunit
K6J81_RS18565	COG0651	ATP synthesis coupled electron transport
K6J81_RS18570	COG1863	multisubunit Na H antiporter MnhE subunit
K6J81_RS18575	COG2212	antiporter activity
K6J81_RS18580	COG1320	monovalent cation:proton antiporter activity
K6J81_RS18590	COG0242	peptide deformylase activity
K6J81_RS18600	COG0579	oxidoreductase
K6J81_RS18635	COG2271	Major facilitator Superfamily
K6J81_RS18640	COG0584	glycerophosphoryl diester phosphodiesterase
K6J81_RS18650	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6J81_RS18660	COG1609	Transcriptional regulator
K6J81_RS18665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J81_RS18670	COG1879	ABC-type sugar transport system periplasmic component
K6J81_RS18675	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6J81_RS18680	COG1129	ABC transporter
K6J81_RS18685	COG1869	D-ribose catabolic process
K6J81_RS18700	COG3501	Rhs element vgr protein
K6J81_RS18700	COG3409	Peptidoglycan-binding domain 1 protein
K6J81_RS18725	COG3829	transcription factor binding
K6J81_RS18790	COG0564	pseudouridine synthase activity
K6J81_RS18800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6J81_RS18805	COG2771	luxR family
K6J81_RS18805	COG2200	EAL domain
K6J81_RS18815	COG0673	inositol 2-dehydrogenase activity
K6J81_RS18820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6J81_RS18850	COG1342	Belongs to the UPF0251 family
K6J81_RS18860	COG1301	dicarboxylic acid transport
K6J81_RS18880	COG2814	Major facilitator Superfamily
K6J81_RS18885	COG0583	DNA-binding transcription factor activity
K6J81_RS18890	COG5001	Diguanylate cyclase
K6J81_RS18890	COG3300	MHYT domain
K6J81_RS18895	COG0739	heme binding
K6J81_RS18905	COG0659	secondary active sulfate transmembrane transporter activity
K6J81_RS18910	COG3314	Sporulation integral membrane protein YlbJ
K6J81_RS18925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6J81_RS18930	COG0581	inorganic phosphate transmembrane transporter activity
K6J81_RS18935	COG0573	inorganic phosphate transmembrane transporter activity
K6J81_RS18940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6J81_RS18970	COG1770	oligopeptidase
K6J81_RS18975	COG0513	Belongs to the DEAD box helicase family
K6J81_RS18985	COG1376	ErfK ybiS ycfS ynhG family protein
K6J81_RS18985	COG1388	LysM domain
K6J81_RS18990	COG0415	Belongs to the DNA photolyase family
K6J81_RS19000	COG3272	Protein of unknown function (DUF1722)
K6J81_RS19005	COG0813	purine-nucleoside phosphorylase activity
K6J81_RS19030	COG1566	PFAM secretion protein HlyD family protein
K6J81_RS19050	COG0786	glutamate:sodium symporter activity
K6J81_RS19065	COG1999	signal sequence binding
K6J81_RS19075	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6J81_RS19080	COG0671	phosphoesterase, PA-phosphatase related
K6J81_RS19140	COG0840	transmembrane signaling receptor activity
K6J81_RS19305	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6J81_RS19355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A