locus-tag	class	description
K6J80_RS00040	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
K6J80_RS00045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6J80_RS00060	COG0183	Belongs to the thiolase family
K6J80_RS00065	COG0583	DNA-binding transcription factor activity
K6J80_RS00070	COG2814	Major facilitator Superfamily
K6J80_RS00075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6J80_RS00080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6J80_RS00085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6J80_RS00090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6J80_RS00095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6J80_RS00100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6J80_RS00105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6J80_RS00115	COG0356	it plays a direct role in the translocation of protons across the membrane
K6J80_RS00120	COG3312	ion transport
K6J80_RS00125	COG1475	DNA binding
K6J80_RS00130	COG1192	Involved in chromosome partitioning
K6J80_RS00140	COG0445	tRNA wobble uridine modification
K6J80_RS00145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6J80_RS00150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6J80_RS00155	COG0706	membrane insertase activity
K6J80_RS00165	COG0594	ribonuclease P activity
K6J80_RS00170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6J80_RS00175	COG1126	abc transporter atp-binding protein
K6J80_RS00190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6J80_RS00195	COG0592	DNA-directed DNA polymerase activity
K6J80_RS00200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6J80_RS00205	COG0187	DNA topoisomerase II activity
K6J80_RS00215	COG0071	Belongs to the small heat shock protein (HSP20) family
K6J80_RS00220	COG3977	Valine--pyruvate aminotransferase
K6J80_RS00225	COG0751	glycine-tRNA ligase activity
K6J80_RS00230	COG0752	glycyl-tRNA synthetase alpha subunit
K6J80_RS00235	COG2119	membrane
K6J80_RS00245	COG0425	Belongs to the sulfur carrier protein TusA family
K6J80_RS00255	COG0604	alcohol dehydrogenase
K6J80_RS00265	COG0129	dihydroxy-acid dehydratase activity
K6J80_RS00270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6J80_RS00285	COG0606	chelatase, subunit chli
K6J80_RS00290	COG0204	Acyl-transferase
K6J80_RS00295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6J80_RS00300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6J80_RS00310	COG3084	Protein conserved in bacteria
K6J80_RS00315	COG4326	sporulation control protein
K6J80_RS00320	COG1272	protein, Hemolysin III
K6J80_RS00335	COG0569	domain protein
K6J80_RS00340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6J80_RS00340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6J80_RS00345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6J80_RS00350	COG0242	peptide deformylase activity
K6J80_RS00355	COG1652	LysM domain
K6J80_RS00360	COG0758	DNA mediated transformation
K6J80_RS00365	COG2922	Belongs to the Smg family
K6J80_RS00370	COG0551	DNA topoisomerase type I activity
K6J80_RS00375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6J80_RS00380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6J80_RS00385	COG0009	L-threonylcarbamoyladenylate synthase
K6J80_RS00390	COG0408	coproporphyrinogen oxidase activity
K6J80_RS00395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6J80_RS00405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6J80_RS00445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6J80_RS00450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6J80_RS00460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6J80_RS00465	COG2104	thiamine diphosphate biosynthetic process
K6J80_RS00470	COG2022	thiamine diphosphate biosynthetic process
K6J80_RS00475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6J80_RS00480	COG0006	proline dipeptidase activity
K6J80_RS00480	COG0006	proline dipeptidase activity
K6J80_RS00500	COG1522	sequence-specific DNA binding
K6J80_RS00505	COG5001	Diguanylate cyclase
K6J80_RS00505	COG5002	protein histidine kinase activity
K6J80_RS00525	COG0589	response to stress
K6J80_RS00530	COG1528	Iron-storage protein
K6J80_RS00540	COG2081	HI0933 family
K6J80_RS00550	COG1322	Protein conserved in bacteria
K6J80_RS00555	COG2226	methyltransferase
K6J80_RS00570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6J80_RS00575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6J80_RS00580	COG0805	protein transport
K6J80_RS00585	COG1858	cytochrome C peroxidase
K6J80_RS00590	COG0534	Mate efflux family protein
K6J80_RS00600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6J80_RS00610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K6J80_RS00615	COG3161	chorismate lyase activity
K6J80_RS00620	COG1580	Controls the rotational direction of flagella during chemotaxis
K6J80_RS00625	COG0840	transmembrane signaling receptor activity
K6J80_RS00635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6J80_RS00640	COG0084	hydrolase, TatD family'
K6J80_RS00655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6J80_RS00655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6J80_RS00675	COG3078	GTPase activator activity
K6J80_RS00690	COG3071	HemY protein
K6J80_RS00695	COG2959	enzyme of heme biosynthesis
K6J80_RS00700	COG1587	Uroporphyrinogen-III synthase
K6J80_RS00705	COG0181	hydroxymethylbilane synthase activity
K6J80_RS00715	COG1965	Belongs to the frataxin family
K6J80_RS00725	COG0019	diaminopimelate decarboxylase activity
K6J80_RS00730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K6J80_RS00740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K6J80_RS00745	COG1011	Hydrolase
K6J80_RS00750	COG2199	diguanylate cyclase activity
K6J80_RS00750	COG2200	EAL domain
K6J80_RS00750	COG3287	FIST C domain
K6J80_RS00765	COG0561	phosphatase activity
K6J80_RS00770	COG2267	carboxylic ester hydrolase activity
K6J80_RS00775	COG1280	lysine exporter protein (LysE YggA)
K6J80_RS00780	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6J80_RS00785	COG0783	Belongs to the Dps family
K6J80_RS00815	COG0742	ribosomal rna small subunit methyltransferase
K6J80_RS00820	COG0552	protein localization to endoplasmic reticulum
K6J80_RS00825	COG2884	Cell division ATP-binding protein ftsE
K6J80_RS00830	COG2177	Part of the ABC transporter FtsEX involved in
K6J80_RS00835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6J80_RS00840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J80_RS00855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6J80_RS00860	COG4206	TonB-dependent receptor
K6J80_RS00865	COG1404	Belongs to the peptidase S8 family
K6J80_RS00870	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6J80_RS00905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K6J80_RS00910	COG3300	MHYT domain
K6J80_RS00910	COG5001	Diguanylate cyclase
K6J80_RS00920	COG3852	Histidine kinase
K6J80_RS00930	COG0174	glutamine synthetase
K6J80_RS00940	COG1217	gtp-binding protein TYPA
K6J80_RS00950	COG1295	ribonuclease BN
K6J80_RS00955	COG1490	D-aminoacyl-tRNA deacylase activity
K6J80_RS00960	COG0456	acetyltransferase
K6J80_RS00970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6J80_RS00975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6J80_RS00980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6J80_RS00985	COG3031	protein transport across the cell outer membrane
K6J80_RS00995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J80_RS01000	COG1459	type II secretion system
K6J80_RS01005	COG2165	general secretion pathway protein
K6J80_RS01010	COG2165	general secretion pathway protein
K6J80_RS01015	COG2165	general secretion pathway protein
K6J80_RS01020	COG4795	General secretion pathway protein
K6J80_RS01025	COG3156	type II secretion system protein K
K6J80_RS01030	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6J80_RS01035	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K6J80_RS01045	COG1218	3'(2'),5'-bisphosphate nucleotidase
K6J80_RS01050	COG0494	nUDIX hydrolase
K6J80_RS01060	COG1040	competence protein
K6J80_RS01070	COG0596	Alpha beta hydrolase
K6J80_RS01080	COG2183	response to ionizing radiation
K6J80_RS01085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6J80_RS01100	COG2233	PERMEase
K6J80_RS01105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6J80_RS01110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6J80_RS01115	COG1758	RNA polymerase activity
K6J80_RS01120	COG0194	GDP metabolic process
K6J80_RS01125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6J80_RS01130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6J80_RS01150	COG4232	protein-disulfide reductase activity
K6J80_RS01160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6J80_RS01165	COG1027	Aspartate ammonia-lyase
K6J80_RS01170	COG3706	GGDEF domain
K6J80_RS01175	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6J80_RS01180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6J80_RS01195	COG0745	RESPONSE REGULATOR receiver
K6J80_RS01205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6J80_RS01210	COG0205	6-phosphofructokinase activity
K6J80_RS01220	COG3074	FtsZ-dependent cytokinesis
K6J80_RS01225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6J80_RS01230	COG0527	aspartate kinase activity
K6J80_RS01230	COG0460	homoserine dehydrogenase
K6J80_RS01235	COG0626	cystathionine gamma-synthase activity
K6J80_RS01240	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K6J80_RS01245	COG0281	malic enzyme
K6J80_RS01250	COG0254	rRNA binding
K6J80_RS01255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6J80_RS01260	COG1609	Transcriptional regulator
K6J80_RS01265	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6J80_RS01270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6J80_RS01275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6J80_RS01280	COG1575	Belongs to the MenA family. Type 1 subfamily
K6J80_RS01285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6J80_RS01290	COG0534	Mate efflux family protein
K6J80_RS01295	COG0149	triose-phosphate isomerase activity
K6J80_RS01320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6J80_RS01325	COG0459	protein refolding
K6J80_RS01335	COG1509	lysine 2,3-aminomutase activity
K6J80_RS01340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6J80_RS01350	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K6J80_RS01355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6J80_RS01360	COG1053	succinate dehydrogenase
K6J80_RS01365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K6J80_RS01370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6J80_RS01375	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K6J80_RS01380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6J80_RS01385	COG1045	serine acetyltransferase
K6J80_RS01395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K6J80_RS01400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6J80_RS01405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6J80_RS01410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6J80_RS01415	COG0137	argininosuccinate synthase activity
K6J80_RS01420	COG0165	Argininosuccinate lyase
K6J80_RS01430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J80_RS01435	COG0678	peroxiredoxin activity
K6J80_RS01435	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6J80_RS01445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6J80_RS01475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6J80_RS01480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6J80_RS01490	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6J80_RS01495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6J80_RS01500	COG0546	phosphoglycolate phosphatase activity
K6J80_RS01505	COG0180	Tryptophanyl-tRNA synthetase
K6J80_RS01530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6J80_RS01540	COG1012	belongs to the aldehyde dehydrogenase family
K6J80_RS01555	COG3954	Phosphoribulokinase
K6J80_RS01565	COG0429	hydrolase of the alpha beta-hydrolase fold
K6J80_RS01575	COG0488	(ABC) transporter
K6J80_RS01580	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6J80_RS01595	COG1047	Peptidyl-prolyl cis-trans
K6J80_RS01610	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K6J80_RS01615	COG3083	sulfuric ester hydrolase activity
K6J80_RS01620	COG0557	exoribonuclease II activity
K6J80_RS01625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6J80_RS01630	COG0051	transcription antitermination factor activity, RNA binding
K6J80_RS01635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6J80_RS01640	COG0088	Forms part of the polypeptide exit tunnel
K6J80_RS01645	COG0089	rRNA binding
K6J80_RS01650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6J80_RS01655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K6J80_RS01660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K6J80_RS01665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6J80_RS01670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6J80_RS01675	COG0255	Belongs to the universal ribosomal protein uL29 family
K6J80_RS01680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6J80_RS01685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6J80_RS01690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K6J80_RS01695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6J80_RS01700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6J80_RS01705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6J80_RS01715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6J80_RS01720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6J80_RS01725	COG1841	ribosomal large subunit assembly
K6J80_RS01735	COG0201	protein transport
K6J80_RS01740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6J80_RS01745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6J80_RS01750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6J80_RS01755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6J80_RS01760	COG0202	RNA polymerase activity
K6J80_RS01765	COG0203	ribosomal protein L17
K6J80_RS01775	COG0545	Peptidyl-prolyl cis-trans isomerase
K6J80_RS01780	COG3061	Opacity-associated protein A
K6J80_RS01780	COG3266	domain, Protein
K6J80_RS01785	COG0697	spore germination
K6J80_RS01790	COG2153	protein acetylation
K6J80_RS01795	COG0513	Belongs to the DEAD box helicase family
K6J80_RS01810	COG1648	precorrin-2 dehydrogenase activity
K6J80_RS01810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6J80_RS01825	COG0529	Catalyzes the synthesis of activated sulfate
K6J80_RS01845	COG1136	(ABC) transporter
K6J80_RS01860	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K6J80_RS01865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J80_RS01870	COG0729	surface antigen
K6J80_RS01880	COG2105	PFAM AIG2 family protein
K6J80_RS01885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K6J80_RS01895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6J80_RS01900	COG0163	prenyltransferase activity
K6J80_RS01915	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K6J80_RS01920	COG3028	Belongs to the UPF0307 family
K6J80_RS01925	COG0312	modulator of DNA gyrase
K6J80_RS01930	COG2239	Acts as a magnesium transporter
K6J80_RS01935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J80_RS01940	COG1660	Displays ATPase and GTPase activities
K6J80_RS01945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J80_RS01950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6J80_RS01960	COG1137	ATPase activity
K6J80_RS01965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K6J80_RS01980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6J80_RS01980	COG0517	IMP dehydrogenase activity
K6J80_RS01990	COG1127	ABC transporter
K6J80_RS01995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K6J80_RS02000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6J80_RS02005	COG2854	intermembrane phospholipid transfer
K6J80_RS02015	COG5007	Belongs to the BolA IbaG family
K6J80_RS02020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6J80_RS02030	COG0251	oxidation-reduction process
K6J80_RS02040	COG0540	Belongs to the ATCase OTCase family
K6J80_RS02050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6J80_RS02060	COG0564	pseudouridine synthase activity
K6J80_RS02070	COG0525	valine-tRNA ligase activity
K6J80_RS02075	COG2927	DNA polymerase III (CHI subunit)
K6J80_RS02080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6J80_RS02085	COG0795	lipopolysaccharide-transporting ATPase activity
K6J80_RS02090	COG0795	lipopolysaccharide-transporting ATPase activity
K6J80_RS02105	COG3437	response regulator, receiver
K6J80_RS02150	COG0066	3-isopropylmalate dehydratase activity
K6J80_RS02155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6J80_RS02160	COG0473	3-isopropylmalate dehydrogenase activity
K6J80_RS02185	COG0583	DNA-binding transcription factor activity
K6J80_RS02190	COG1022	Amp-dependent synthetase and ligase
K6J80_RS02195	COG0028	Belongs to the TPP enzyme family
K6J80_RS02200	COG0440	acetolactate synthase activity
K6J80_RS02210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K6J80_RS02215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6J80_RS02225	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6J80_RS02230	COG3079	Belongs to the UPF0149 family
K6J80_RS02235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J80_RS02240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J80_RS02255	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K6J80_RS02265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6J80_RS02270	COG1595	DNA-templated transcription, initiation
K6J80_RS02285	COG3086	response to oxidative stress
K6J80_RS02290	COG0481	GTPase activity
K6J80_RS02305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6J80_RS02310	COG1381	Involved in DNA repair and RecF pathway recombination
K6J80_RS02315	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K6J80_RS02335	COG5001	Diguanylate cyclase
K6J80_RS02350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6J80_RS02355	COG3956	TIGRFAM MazG family protein
K6J80_RS02360	COG0504	CTP synthase activity
K6J80_RS02365	COG0148	phosphopyruvate hydratase activity
K6J80_RS02375	COG3267	Type II secretory pathway component ExeA
K6J80_RS02375	COG3409	Peptidoglycan-binding domain 1 protein
K6J80_RS02385	COG4991	sh3 domain protein
K6J80_RS02390	COG0306	phosphate transporter
K6J80_RS02395	COG1392	Phosphate transport regulator
K6J80_RS02400	COG3025	triphosphatase activity
K6J80_RS02405	COG0840	transmembrane signaling receptor activity
K6J80_RS02410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K6J80_RS02420	COG1538	Outer membrane efflux protein
K6J80_RS02425	COG0494	nUDIX hydrolase
K6J80_RS02430	COG3151	Protein conserved in bacteria
K6J80_RS02440	COG3150	esterase
K6J80_RS02445	COG0187	DNA topoisomerase II activity
K6J80_RS02450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6J80_RS02460	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K6J80_RS02465	COG0237	dephospho-CoA kinase activity
K6J80_RS02475	COG1459	type II secretion system
K6J80_RS02480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J80_RS02500	COG0716	FMN binding
K6J80_RS02505	COG4974	Belongs to the 'phage' integrase family
K6J80_RS02510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6J80_RS02515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6J80_RS02520	COG0737	Belongs to the 5'-nucleotidase family
K6J80_RS02525	COG2186	Transcriptional regulator
K6J80_RS02530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K6J80_RS02535	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6J80_RS02540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J80_RS02555	COG3116	cell division
K6J80_RS02560	COG0768	penicillin binding
K6J80_RS02565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6J80_RS02570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6J80_RS02580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6J80_RS02585	COG0772	Belongs to the SEDS family
K6J80_RS02595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6J80_RS02600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6J80_RS02605	COG0849	cell division
K6J80_RS02610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6J80_RS02615	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K6J80_RS02625	COG0653	protein targeting
K6J80_RS02630	COG0494	nUDIX hydrolase
K6J80_RS02635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6J80_RS02645	COG0505	Belongs to the CarA family
K6J80_RS02650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6J80_RS02665	COG4172	Belongs to the ABC transporter superfamily
K6J80_RS02675	COG0730	response to heat
K6J80_RS02680	COG0583	DNA-binding transcription factor activity
K6J80_RS02685	COG2860	membrane
K6J80_RS02690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6J80_RS02700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6J80_RS02710	COG0493	'glutamate synthase
K6J80_RS02715	COG0067	glutamate synthase
K6J80_RS02715	COG0069	glutamate synthase activity
K6J80_RS02715	COG0070	glutamate synthase
K6J80_RS02730	COG1242	4 iron, 4 sulfur cluster binding
K6J80_RS02735	COG2203	Gaf domain
K6J80_RS02735	COG3706	GGDEF domain
K6J80_RS02735	COG4251	negative regulation of phosphorylation
K6J80_RS02735	COG5001	Diguanylate cyclase
K6J80_RS02740	COG0784	Response regulator, receiver
K6J80_RS02740	COG5002	protein histidine kinase activity
K6J80_RS02740	COG2198	Histidine kinase
K6J80_RS02745	COG0745	RESPONSE REGULATOR receiver
K6J80_RS02755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K6J80_RS02780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6J80_RS02785	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K6J80_RS02790	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6J80_RS02795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6J80_RS02810	COG1115	amino acid carrier protein
K6J80_RS02815	COG3022	response to hydroperoxide
K6J80_RS02825	COG0084	hydrolase, TatD family'
K6J80_RS02830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6J80_RS02840	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6J80_RS02850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6J80_RS02855	COG0813	purine-nucleoside phosphorylase activity
K6J80_RS02865	COG0560	Phosphoserine phosphatase
K6J80_RS02875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6J80_RS02880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6J80_RS02885	COG1022	Amp-dependent synthetase and ligase
K6J80_RS02900	COG3250	beta-galactosidase activity
K6J80_RS02905	COG1609	Transcriptional regulator
K6J80_RS02910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J80_RS02925	COG0189	ligase activity
K6J80_RS02925	COG0569	domain protein
K6J80_RS02930	COG0456	acetyltransferase
K6J80_RS02940	COG2171	N-acyltransferase activity
K6J80_RS02945	COG3141	response to X-ray
K6J80_RS02960	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K6J80_RS02965	COG1074	ATP-dependent DNA helicase activity
K6J80_RS02970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6J80_RS02980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K6J80_RS02980	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6J80_RS02990	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K6J80_RS02995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6J80_RS03000	COG2166	iron-sulfur cluster assembly
K6J80_RS03005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6J80_RS03010	COG0693	protein deglycase activity
K6J80_RS03015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6J80_RS03020	COG3248	Nucleoside-binding outer membrane protein
K6J80_RS03030	COG1595	DNA-templated transcription, initiation
K6J80_RS03040	COG2211	Major facilitator Superfamily
K6J80_RS03045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6J80_RS03055	COG2813	Specifically methylates the guanine in position
K6J80_RS03060	COG0271	Belongs to the BolA IbaG family
K6J80_RS03065	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J80_RS03070	COG1805	sodium ion transport
K6J80_RS03075	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J80_RS03080	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J80_RS03085	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K6J80_RS03090	COG2871	sodium ion transport
K6J80_RS03095	COG1477	protein flavinylation
K6J80_RS03120	COG3328	transposase activity
K6J80_RS03125	COG3706	GGDEF domain
K6J80_RS03130	COG0733	neurotransmitter:sodium symporter activity
K6J80_RS03140	COG0189	ligase activity
K6J80_RS03145	COG0189	ligase activity
K6J80_RS03145	COG4067	protein conserved in archaea
K6J80_RS03150	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6J80_RS03155	COG2252	PERMEase
K6J80_RS03160	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K6J80_RS03165	COG1073	alpha beta
K6J80_RS03175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6J80_RS03180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6J80_RS03185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6J80_RS03190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6J80_RS03190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6J80_RS03205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6J80_RS03210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6J80_RS03220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6J80_RS03230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K6J80_RS03235	COG0024	Methionine aminopeptidase
K6J80_RS03240	COG0052	Belongs to the universal ribosomal protein uS2 family
K6J80_RS03245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6J80_RS03250	COG0528	UMP kinase activity
K6J80_RS03255	COG0233	cytoplasmic translational termination
K6J80_RS03260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6J80_RS03265	COG0575	Belongs to the CDS family
K6J80_RS03270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6J80_RS03275	COG0750	zinc metalloprotease
K6J80_RS03285	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K6J80_RS03290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J80_RS03295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6J80_RS03300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J80_RS03305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J80_RS03310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6J80_RS03320	COG0825	malonyl-CoA metabolic process
K6J80_RS03325	COG0037	tRNA processing
K6J80_RS03335	COG3479	Phenolic acid decarboxylase
K6J80_RS03340	COG0347	Belongs to the P(II) protein family
K6J80_RS03345	COG3021	interspecies interaction between organisms
K6J80_RS03350	COG0741	lytic transglycosylase activity
K6J80_RS03350	COG1388	LysM domain
K6J80_RS03355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6J80_RS03360	COG2226	methyltransferase
K6J80_RS03365	COG0328	RNA-DNA hybrid ribonuclease activity
K6J80_RS03380	COG1960	acyl-CoA dehydrogenase activity
K6J80_RS03385	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6J80_RS03390	COG0121	glutamine amidotransferase
K6J80_RS03395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6J80_RS03400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6J80_RS03405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6J80_RS03415	COG1187	pseudouridine synthase activity
K6J80_RS03420	COG2840	Smr protein MutS2
K6J80_RS03435	COG3735	TraB family
K6J80_RS03450	COG2608	mercury ion transmembrane transporter activity
K6J80_RS03450	COG2217	Heavy metal translocating P-type atpase
K6J80_RS03455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6J80_RS03470	COG4774	siderophore transport
K6J80_RS03470	COG1629	transport
K6J80_RS03480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6J80_RS03480	COG3433	isochorismatase activity
K6J80_RS03480	COG2226	methyltransferase
K6J80_RS03515	COG0835	chemotaxis
K6J80_RS03515	COG0784	Response regulator, receiver
K6J80_RS03520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6J80_RS03525	COG1815	bacterial-type flagellum-dependent cell motility
K6J80_RS03540	COG1749	Flagellar hook protein flgE
K6J80_RS03545	COG4787	bacterial-type flagellum-dependent cell motility
K6J80_RS03555	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K6J80_RS03560	COG1706	bacterial-type flagellum-dependent cell motility
K6J80_RS03565	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6J80_RS03565	COG3951	Flagellar rod assembly protein muramidase FlgJ
K6J80_RS03580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J80_RS03585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J80_RS03670	COG0012	GTP binding
K6J80_RS03675	COG0193	aminoacyl-tRNA hydrolase activity
K6J80_RS03680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6J80_RS03685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6J80_RS03690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K6J80_RS03695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6J80_RS03700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6J80_RS03705	COG2890	protein-(glutamine-N5) methyltransferase activity
K6J80_RS03715	COG2912	Transglutaminase-like superfamily
K6J80_RS03720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K6J80_RS03725	COG0737	Belongs to the 5'-nucleotidase family
K6J80_RS03730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6J80_RS03735	COG2233	PERMEase
K6J80_RS03755	COG1393	Belongs to the ArsC family
K6J80_RS03760	COG4783	chaperone-mediated protein folding
K6J80_RS03780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6J80_RS03795	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K6J80_RS03805	COG1876	peptidase activity
K6J80_RS03815	COG1393	Belongs to the ArsC family
K6J80_RS03835	COG2837	iron assimilation
K6J80_RS03840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J80_RS03845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J80_RS03850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6J80_RS03855	COG1334	flagellar protein FlaG
K6J80_RS03860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6J80_RS03870	COG1516	flagellar protein fliS
K6J80_RS03890	COG1677	Flagellar hook-basal body complex protein FliE
K6J80_RS03900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6J80_RS03905	COG1317	bacterial-type flagellum organization
K6J80_RS03930	COG1580	Controls the rotational direction of flagella during chemotaxis
K6J80_RS03955	COG1987	bacterial-type flagellum assembly
K6J80_RS03960	COG1684	flagellar biosynthetic protein fliR
K6J80_RS03970	COG2840	Smr protein MutS2
K6J80_RS03975	COG2890	protein-(glutamine-N5) methyltransferase activity
K6J80_RS03980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6J80_RS03985	COG2860	membrane
K6J80_RS03990	COG3101	peptidyl-lysine hydroxylation
K6J80_RS04000	COG0431	NADPH-dependent FMN reductase
K6J80_RS04010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6J80_RS04015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6J80_RS04020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6J80_RS04025	COG0735	belongs to the Fur family
K6J80_RS04035	COG0583	DNA-binding transcription factor activity
K6J80_RS04045	COG1346	cytolysis
K6J80_RS04060	COG0596	Alpha beta hydrolase
K6J80_RS04065	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K6J80_RS04070	COG0033	Phosphoglucomutase
K6J80_RS04080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6J80_RS04085	COG0372	Belongs to the citrate synthase family
K6J80_RS04090	COG2009	succinate dehydrogenase
K6J80_RS04095	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K6J80_RS04100	COG1053	succinate dehydrogenase
K6J80_RS04115	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6J80_RS04120	COG0045	succinate-CoA ligase (ADP-forming) activity
K6J80_RS04130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6J80_RS04135	COG1121	(ABC) transporter
K6J80_RS04140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K6J80_RS04145	COG4977	sequence-specific DNA binding
K6J80_RS04150	COG1918	ferrous iron import across plasma membrane
K6J80_RS04170	COG0018	arginyl-trna synthetase
K6J80_RS04180	COG1025	Belongs to the peptidase M16 family
K6J80_RS04185	COG2062	phosphohistidine phosphatase, SixA
K6J80_RS04215	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K6J80_RS04220	COG0643	Histidine kinase
K6J80_RS04220	COG0784	Response regulator, receiver
K6J80_RS04220	COG2198	Histidine kinase
K6J80_RS04225	COG2201	protein-glutamate methylesterase activity
K6J80_RS04230	COG1192	Involved in chromosome partitioning
K6J80_RS04240	COG0835	chemotaxis
K6J80_RS04255	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6J80_RS04260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6J80_RS04270	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K6J80_RS04275	COG1138	Cytochrome C-type biogenesis protein
K6J80_RS04280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6J80_RS04285	COG4235	cytochrome complex assembly
K6J80_RS04285	COG3088	subunit of a heme lyase
K6J80_RS04295	COG2853	Lipoprotein
K6J80_RS04315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K6J80_RS04325	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6J80_RS04340	COG3083	sulfuric ester hydrolase activity
K6J80_RS04345	COG3082	Protein of unknown function (DUF1414)
K6J80_RS04350	COG3081	Nucleoid-associated protein
K6J80_RS04360	COG1757	Na H antiporter
K6J80_RS04365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6J80_RS04370	COG2095	MarC family integral membrane protein
K6J80_RS04375	COG1012	belongs to the aldehyde dehydrogenase family
K6J80_RS04375	COG1454	alcohol dehydrogenase
K6J80_RS04385	COG0659	secondary active sulfate transmembrane transporter activity
K6J80_RS04390	COG1530	ribonuclease E activity
K6J80_RS04395	COG0564	pseudouridine synthase activity
K6J80_RS04400	COG0424	maF-like protein
K6J80_RS04405	COG1399	metal-binding, possibly nucleic acid-binding protein
K6J80_RS04410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K6J80_RS04415	COG0416	fatty acid biosynthetic process
K6J80_RS04420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6J80_RS04435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6J80_RS04445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6J80_RS04450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6J80_RS04455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6J80_RS04465	COG0084	hydrolase, TatD family'
K6J80_RS04470	COG1263	PTS System
K6J80_RS04470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J80_RS04480	COG0733	neurotransmitter:sodium symporter activity
K6J80_RS04495	COG4667	esterase of the alpha-beta hydrolase superfamily
K6J80_RS04505	COG1940	carbohydrate kinase activity
K6J80_RS04510	COG0835	chemotaxis
K6J80_RS04510	COG0784	Response regulator, receiver
K6J80_RS04525	COG2226	methyltransferase
K6J80_RS04535	COG0676	glucose-6-phosphate 1-epimerase activity
K6J80_RS04540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6J80_RS04545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J80_RS04555	COG3139	Protein of unknown function (DUF1315)
K6J80_RS04560	COG0252	asparaginase activity
K6J80_RS04565	COG0616	signal peptide processing
K6J80_RS04570	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6J80_RS04570	COG1902	pentaerythritol trinitrate reductase activity
K6J80_RS04575	COG0788	formyltetrahydrofolate deformylase activity
K6J80_RS04585	COG1199	ATP-dependent helicase activity
K6J80_RS04590	COG1214	PFAM Peptidase M22, glycoprotease
K6J80_RS04605	COG0596	Alpha beta hydrolase
K6J80_RS04610	COG0318	PFAM AMP-dependent synthetase and ligase
K6J80_RS04615	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K6J80_RS04635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6J80_RS04640	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K6J80_RS04645	COG0436	Aminotransferase
K6J80_RS04650	COG1169	isochorismate synthase
K6J80_RS04655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6J80_RS04660	COG0596	Alpha beta hydrolase
K6J80_RS04680	COG3135	benzoate transporter
K6J80_RS04685	COG1396	sequence-specific DNA binding
K6J80_RS04690	COG0840	transmembrane signaling receptor activity
K6J80_RS04705	COG0477	Major facilitator Superfamily
K6J80_RS04725	COG3015	lipoprotein NlpE involved in copper resistance
K6J80_RS04730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K6J80_RS04735	COG2894	cell division
K6J80_RS04740	COG0850	regulation of cytokinetic process
K6J80_RS04745	COG3100	YcgL domain-containing protein
K6J80_RS04750	COG2951	lytic endotransglycosylase activity
K6J80_RS04760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6J80_RS04765	COG3469	chitinase activity
K6J80_RS04765	COG3325	Belongs to the glycosyl hydrolase 18 family
K6J80_RS04770	COG3005	denitrification pathway
K6J80_RS04775	COG0243	molybdopterin cofactor binding
K6J80_RS04790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J80_RS04800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6J80_RS04835	COG4589	Belongs to the CDS family
K6J80_RS04845	COG5001	Diguanylate cyclase
K6J80_RS04845	COG3300	MHYT domain
K6J80_RS04855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K6J80_RS04860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6J80_RS04865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6J80_RS04870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6J80_RS04880	COG4191	Histidine kinase
K6J80_RS04890	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6J80_RS04900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6J80_RS04905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6J80_RS04910	COG0776	regulation of translation
K6J80_RS04915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6J80_RS04920	COG1555	photosystem II stabilization
K6J80_RS04925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6J80_RS04930	COG0539	negative regulation of cytoplasmic translation
K6J80_RS04935	COG0776	regulation of translation
K6J80_RS04940	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K6J80_RS04945	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K6J80_RS04965	COG0583	DNA-binding transcription factor activity
K6J80_RS04975	COG0686	Belongs to the AlaDH PNT family
K6J80_RS04985	COG1674	ftsk spoiiie
K6J80_RS04990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6J80_RS04995	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6J80_RS05000	COG2186	Transcriptional regulator
K6J80_RS05015	COG0537	adenosine 5'-monophosphoramidase activity
K6J80_RS05040	COG3150	esterase
K6J80_RS05045	COG1252	NADH dehydrogenase
K6J80_RS05075	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6J80_RS05080	COG1136	(ABC) transporter
K6J80_RS05085	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6J80_RS05095	COG0658	competence protein
K6J80_RS05095	COG2333	competence protein COMEC
K6J80_RS05100	COG1132	(ABC) transporter
K6J80_RS05110	COG2835	tetraacyldisaccharide 4'-kinase activity
K6J80_RS05115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K6J80_RS05120	COG2719	SpoVR family
K6J80_RS05125	COG2718	Belongs to the UPF0229 family
K6J80_RS05130	COG2766	serine protein kinase
K6J80_RS05135	COG3013	Belongs to the UPF0304 family
K6J80_RS05145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6J80_RS05150	COG0840	transmembrane signaling receptor activity
K6J80_RS05160	COG1882	Formate acetyltransferase
K6J80_RS05185	COG4160	amino acid transport
K6J80_RS05190	COG0708	Exodeoxyribonuclease III
K6J80_RS05195	COG0840	transmembrane signaling receptor activity
K6J80_RS05205	COG3923	Primosomal replication protein n
K6J80_RS05210	COG0730	response to heat
K6J80_RS05215	COG1199	ATP-dependent helicase activity
K6J80_RS05220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6J80_RS05225	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6J80_RS05230	COG3012	SEC-C Motif Domain Protein
K6J80_RS05235	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6J80_RS05240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K6J80_RS05245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6J80_RS05250	COG0215	cysteine-tRNA ligase activity
K6J80_RS05255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K6J80_RS05260	COG0632	four-way junction helicase activity
K6J80_RS05270	COG1271	oxidase subunit
K6J80_RS05275	COG1294	oxidase, subunit
K6J80_RS05280	COG4890	Cyd operon protein YbgT
K6J80_RS05290	COG0824	Thioesterase
K6J80_RS05295	COG0811	peptide transport
K6J80_RS05310	COG0823	Involved in the tonB-independent uptake of proteins
K6J80_RS05315	COG2885	chlorophyll binding
K6J80_RS05325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6J80_RS05335	COG0784	Response regulator, receiver
K6J80_RS05335	COG5002	protein histidine kinase activity
K6J80_RS05345	COG1482	cell wall glycoprotein biosynthetic process
K6J80_RS05355	COG2207	Transcriptional regulator
K6J80_RS05365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6J80_RS05375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6J80_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
K6J80_RS05390	COG3284	Transcriptional regulator
K6J80_RS05395	COG4628	conserved protein (DUF2132)
K6J80_RS05405	COG0415	Belongs to the DNA photolyase family
K6J80_RS05485	COG0488	(ABC) transporter
K6J80_RS05525	COG3941	tape measure
K6J80_RS05545	COG2003	Belongs to the UPF0758 family
K6J80_RS05555	COG4409	exo-alpha-(2->6)-sialidase activity
K6J80_RS05560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6J80_RS05565	COG1940	carbohydrate kinase activity
K6J80_RS05575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6J80_RS05580	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K6J80_RS05585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K6J80_RS05590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6J80_RS05595	COG1737	Transcriptional regulator
K6J80_RS05600	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
K6J80_RS05605	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
K6J80_RS05625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K6J80_RS05645	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K6J80_RS05665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6J80_RS05670	COG0582	viral genome integration into host DNA
K6J80_RS05675	COG0582	viral genome integration into host DNA
K6J80_RS05690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J80_RS05700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K6J80_RS05700	COG3008	intermembrane lipid transfer
K6J80_RS05705	COG2995	paraquat-inducible protein a
K6J80_RS05710	COG0668	transmembrane transport
K6J80_RS05730	COG1309	transcriptional regulator
K6J80_RS05735	COG1012	belongs to the aldehyde dehydrogenase family
K6J80_RS05765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6J80_RS05770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K6J80_RS05795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6J80_RS05805	COG0297	glycogen (starch) synthase activity
K6J80_RS05825	COG3070	regulator of competence-specific genes
K6J80_RS05830	COG1609	Transcriptional regulator
K6J80_RS05835	COG3381	protein complex oligomerization
K6J80_RS05840	COG0745	RESPONSE REGULATOR receiver
K6J80_RS05850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6J80_RS05860	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K6J80_RS05885	COG5001	Diguanylate cyclase
K6J80_RS05890	COG0612	Peptidase, M16
K6J80_RS05905	COG0583	DNA-binding transcription factor activity
K6J80_RS05910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6J80_RS05920	COG2350	Protein conserved in bacteria
K6J80_RS05925	COG1607	acyl-coa hydrolase
K6J80_RS05940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6J80_RS05945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6J80_RS05955	COG2116	formate transmembrane transporter activity
K6J80_RS05965	COG4459	periplasmic nitrate reductase
K6J80_RS05970	COG3005	denitrification pathway
K6J80_RS05975	COG0243	molybdopterin cofactor binding
K6J80_RS05995	COG1227	inorganic diphosphatase activity
K6J80_RS06010	COG4172	Belongs to the ABC transporter superfamily
K6J80_RS06025	COG4168	peptide transport system, permease
K6J80_RS06035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6J80_RS06040	COG1842	Phage shock protein A
K6J80_RS06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J80_RS06070	COG2818	Glycosylase
K6J80_RS06075	COG0626	cystathionine gamma-synthase activity
K6J80_RS06085	COG0733	neurotransmitter:sodium symporter activity
K6J80_RS06090	COG0564	pseudouridine synthase activity
K6J80_RS06095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6J80_RS06100	COG4136	ATPase activity
K6J80_RS06105	COG4135	transport system, permease component
K6J80_RS06110	COG4134	Bacterial extracellular solute-binding protein
K6J80_RS06120	COG3313	Fe-S protein
K6J80_RS06130	COG0842	Transport permease protein
K6J80_RS06135	COG1131	(ABC) transporter
K6J80_RS06140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J80_RS06145	COG0814	amino acid
K6J80_RS06155	COG2239	Acts as a magnesium transporter
K6J80_RS06160	COG2205	protein histidine kinase activity
K6J80_RS06160	COG0784	Response regulator, receiver
K6J80_RS06175	COG4934	collagen metabolic process
K6J80_RS06205	COG0840	transmembrane signaling receptor activity
K6J80_RS06215	COG2203	Gaf domain
K6J80_RS06215	COG3706	GGDEF domain
K6J80_RS06215	COG4251	negative regulation of phosphorylation
K6J80_RS06215	COG5001	Diguanylate cyclase
K6J80_RS06220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6J80_RS06245	COG1187	pseudouridine synthase activity
K6J80_RS06250	COG2814	Major facilitator Superfamily
K6J80_RS06260	COG0702	epimerase
K6J80_RS06265	COG0534	Mate efflux family protein
K6J80_RS06270	COG4181	ATPase activity
K6J80_RS06285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K6J80_RS06295	COG1748	Saccharopine dehydrogenase
K6J80_RS06310	COG1538	Outer membrane efflux protein
K6J80_RS06340	COG0583	DNA-binding transcription factor activity
K6J80_RS06350	COG1451	nucleotide metabolic process
K6J80_RS06355	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K6J80_RS06365	COG3063	Type IV pilus biogenesis stability protein PilW
K6J80_RS06370	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6J80_RS06390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J80_RS06405	COG3290	protein histidine kinase activity
K6J80_RS06410	COG4565	transcriptional regulatory protein
K6J80_RS06420	COG0784	Response regulator, receiver
K6J80_RS06420	COG0835	chemotaxis
K6J80_RS06465	COG1085	galactose-1-phosphate uridylyltransferase
K6J80_RS06470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6J80_RS06475	COG2017	converts alpha-aldose to the beta-anomer
K6J80_RS06485	COG2200	EAL domain
K6J80_RS06485	COG2199	diguanylate cyclase activity
K6J80_RS06515	COG0753	catalase activity
K6J80_RS06535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6J80_RS06545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6J80_RS06585	COG1271	oxidase subunit
K6J80_RS06590	COG1294	oxidase, subunit
K6J80_RS06595	COG4591	ABC-type transport system involved in lipoprotein release permease component
K6J80_RS06595	COG1136	(ABC) transporter
K6J80_RS06600	COG0577	efflux transmembrane transporter activity
K6J80_RS06600	COG1136	(ABC) transporter
K6J80_RS06605	COG1136	(ABC) transporter
K6J80_RS06605	COG0577	efflux transmembrane transporter activity
K6J80_RS06625	COG0583	DNA-binding transcription factor activity
K6J80_RS06635	COG2723	6-phospho-beta-galactosidase activity
K6J80_RS06640	COG1609	Transcriptional regulator
K6J80_RS06645	COG0251	oxidation-reduction process
K6J80_RS06650	COG2731	YhcH YjgK YiaL family protein
K6J80_RS06655	COG0584	glycerophosphoryl diester phosphodiesterase
K6J80_RS06660	COG1349	DNA-binding transcription factor activity
K6J80_RS06665	COG3842	ATPase activity
K6J80_RS06670	COG0395	ABC-type sugar transport system, permease component
K6J80_RS06675	COG1175	transmembrane transport
K6J80_RS06690	COG0811	peptide transport
K6J80_RS06695	COG0811	peptide transport
K6J80_RS06700	COG0848	biopolymer transport protein
K6J80_RS06705	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6J80_RS06715	COG1793	dna ligase
K6J80_RS06725	COG0534	Mate efflux family protein
K6J80_RS06735	COG3001	Fructosamine kinase
K6J80_RS06745	COG0791	NLP P60 protein
K6J80_RS06750	COG0840	transmembrane signaling receptor activity
K6J80_RS06760	COG3148	PFAM DTW domain containing protein
K6J80_RS06765	COG1940	carbohydrate kinase activity
K6J80_RS06790	COG0746	molybdenum cofactor guanylyltransferase activity
K6J80_RS06795	COG3842	ATPase activity
K6J80_RS06800	COG4662	Binding-protein-dependent transport system inner membrane component
K6J80_RS06810	COG2204	response regulator
K6J80_RS06815	COG3852	Histidine kinase
K6J80_RS06820	COG0488	(ABC) transporter
K6J80_RS06825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6J80_RS06855	COG3383	formate dehydrogenase (NAD+) activity
K6J80_RS06855	COG0243	molybdopterin cofactor binding
K6J80_RS06860	COG0437	4 iron, 4 sulfur cluster binding
K6J80_RS06875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6J80_RS06880	COG1666	GTP binding
K6J80_RS06885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6J80_RS06900	COG2996	Protein conserved in bacteria
K6J80_RS06910	COG3008	intermembrane lipid transfer
K6J80_RS06915	COG2995	paraquat-inducible protein a
K6J80_RS06920	COG1132	(ABC) transporter
K6J80_RS06925	COG1956	GAF domain-containing protein
K6J80_RS06930	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K6J80_RS06945	COG0308	aminopeptidase N
K6J80_RS06960	COG0167	dihydroorotate dehydrogenase activity
K6J80_RS06970	COG0116	Belongs to the methyltransferase superfamily
K6J80_RS06970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6J80_RS06980	COG0488	(ABC) transporter
K6J80_RS06995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6J80_RS07005	COG3120	sequence-specific DNA binding
K6J80_RS07020	COG3328	transposase activity
K6J80_RS07110	COG1476	TRANSCRIPTIONal
K6J80_RS07140	COG4128	Pfam Zonular occludens toxin
K6J80_RS07155	COG1073	alpha beta
K6J80_RS07155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
K6J80_RS07155	COG3064	Membrane
K6J80_RS07165	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
K6J80_RS07165	COG3064	Membrane
K6J80_RS07165	COG1073	alpha beta
K6J80_RS07170	COG2994	toxin metabolic process
K6J80_RS07195	COG0784	Response regulator, receiver
K6J80_RS07195	COG2205	protein histidine kinase activity
K6J80_RS07210	COG3278	Belongs to the heme-copper respiratory oxidase family
K6J80_RS07225	COG2010	Cytochrome c
K6J80_RS07235	COG2217	Heavy metal translocating P-type atpase
K6J80_RS07250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6J80_RS07255	COG0589	response to stress
K6J80_RS07280	COG3842	ATPase activity
K6J80_RS07290	COG1177	transmembrane transport
K6J80_RS07300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6J80_RS07315	COG1115	amino acid carrier protein
K6J80_RS07320	COG1280	lysine exporter protein (LysE YggA)
K6J80_RS07335	COG3675	Pfam Lipase (class 3)
K6J80_RS07345	COG3501	Rhs element vgr protein
K6J80_RS07355	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6J80_RS07365	COG2814	Major facilitator Superfamily
K6J80_RS07370	COG1566	PFAM secretion protein HlyD family protein
K6J80_RS07375	COG1538	Outer membrane efflux protein
K6J80_RS07385	COG0513	Belongs to the DEAD box helicase family
K6J80_RS07395	COG0840	transmembrane signaling receptor activity
K6J80_RS07400	COG0840	transmembrane signaling receptor activity
K6J80_RS07400	COG3290	protein histidine kinase activity
K6J80_RS07405	COG0835	chemotaxis
K6J80_RS07410	COG2201	protein-glutamate methylesterase activity
K6J80_RS07420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6J80_RS07425	COG0784	Response regulator, receiver
K6J80_RS07425	COG0643	Histidine kinase
K6J80_RS07425	COG2198	Histidine kinase
K6J80_RS07430	COG0643	Histidine kinase
K6J80_RS07430	COG2198	Histidine kinase
K6J80_RS07440	COG0745	RESPONSE REGULATOR receiver
K6J80_RS07455	COG0415	Belongs to the DNA photolyase family
K6J80_RS07460	COG0477	Major facilitator Superfamily
K6J80_RS07465	COG0583	DNA-binding transcription factor activity
K6J80_RS07475	COG0095	Lipoate-protein ligase
K6J80_RS07480	COG0443	Heat shock 70 kDa protein
K6J80_RS07490	COG1643	Atp-dependent helicase
K6J80_RS07520	COG0443	Heat shock 70 kDa protein
K6J80_RS07525	COG0443	Heat shock 70 kDa protein
K6J80_RS07530	COG3706	GGDEF domain
K6J80_RS07560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6J80_RS07565	COG0602	queuosine metabolic process
K6J80_RS07570	COG0561	phosphatase activity
K6J80_RS07580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J80_RS07585	COG4597	amino acid ABC transporter
K6J80_RS07590	COG0765	amino acid transport
K6J80_RS07595	COG1126	abc transporter atp-binding protein
K6J80_RS07600	COG0670	Belongs to the BI1 family
K6J80_RS07605	COG2920	part of a sulfur-relay system
K6J80_RS07610	COG1254	Belongs to the acylphosphatase family
K6J80_RS07615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6J80_RS07620	COG3706	GGDEF domain
K6J80_RS07635	COG3437	response regulator, receiver
K6J80_RS07640	COG0625	glutathione transferase activity
K6J80_RS07650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K6J80_RS07660	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6J80_RS07690	COG0372	Belongs to the citrate synthase family
K6J80_RS07695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6J80_RS07735	COG1129	ABC transporter
K6J80_RS07760	COG0745	RESPONSE REGULATOR receiver
K6J80_RS07765	COG2205	protein histidine kinase activity
K6J80_RS07770	COG3713	MltA-interacting MipA family protein
K6J80_RS07775	COG2990	Protein conserved in bacteria
K6J80_RS07785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J80_RS07785	COG4191	Histidine kinase
K6J80_RS07790	COG0471	metal ion transport
K6J80_RS07800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6J80_RS07815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J80_RS07825	COG3768	UPF0283 membrane protein
K6J80_RS07830	COG3106	COG3106 Predicted ATPase
K6J80_RS07845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6J80_RS07850	COG0494	nUDIX hydrolase
K6J80_RS07855	COG0814	amino acid
K6J80_RS07860	COG1760	l-serine dehydratase
K6J80_RS07865	COG0720	synthase
K6J80_RS07875	COG0017	Asparaginyl-tRNA synthetase
K6J80_RS07880	COG0351	phosphomethylpyrimidine kinase
K6J80_RS07885	COG3437	response regulator, receiver
K6J80_RS07885	COG2770	Histidine kinase
K6J80_RS07890	COG1448	Aminotransferase
K6J80_RS07905	COG0840	transmembrane signaling receptor activity
K6J80_RS07910	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K6J80_RS07915	COG2943	transferase activity, transferring hexosyl groups
K6J80_RS07920	COG1609	Transcriptional regulator
K6J80_RS07930	COG1486	melibiose metabolic process
K6J80_RS07935	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6J80_RS07945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6J80_RS07950	COG0726	polysaccharide deacetylase
K6J80_RS07955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6J80_RS07960	COG1846	Transcriptional regulator
K6J80_RS07985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6J80_RS08000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6J80_RS08005	COG3108	Peptidase M15
K6J80_RS08010	COG2989	Protein conserved in bacteria
K6J80_RS08035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6J80_RS08045	COG2814	Major facilitator Superfamily
K6J80_RS08055	COG1054	Belongs to the UPF0176 family
K6J80_RS08065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6J80_RS08070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6J80_RS08075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6J80_RS08125	COG4139	cobalamin transport
K6J80_RS08145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K6J80_RS08150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K6J80_RS08155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J80_RS08160	COG1823	symporter activity
K6J80_RS08165	COG2925	Exonuclease
K6J80_RS08170	COG1380	Effector of murein hydrolase LrgA
K6J80_RS08175	COG1346	cytolysis
K6J80_RS08210	COG0072	phenylalanine-tRNA ligase activity
K6J80_RS08210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J80_RS08215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6J80_RS08255	COG0322	excinuclease ABC activity
K6J80_RS08260	COG2197	response regulator
K6J80_RS08265	COG0417	DNA replication proofreading
K6J80_RS08270	COG5001	Diguanylate cyclase
K6J80_RS08280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6J80_RS08285	COG3099	Belongs to the UPF0263 family
K6J80_RS08300	COG1228	amidohydrolase
K6J80_RS08305	COG0010	Belongs to the arginase family
K6J80_RS08310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6J80_RS08315	COG2986	histidine ammonia-lyase
K6J80_RS08335	COG0247	lactate metabolic process
K6J80_RS08335	COG0277	FAD linked oxidase domain protein
K6J80_RS08350	COG2885	chlorophyll binding
K6J80_RS08370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6J80_RS08380	COG0281	malic enzyme
K6J80_RS08390	COG2949	membrane
K6J80_RS08395	COG3706	GGDEF domain
K6J80_RS08400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6J80_RS08410	COG0492	ferredoxin-NADP+ reductase activity
K6J80_RS08415	COG4988	ABC transporter
K6J80_RS08420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6J80_RS08425	COG1187	pseudouridine synthase activity
K6J80_RS08430	COG0009	L-threonylcarbamoyladenylate synthase
K6J80_RS08435	COG0613	PHP domain protein
K6J80_RS08445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6J80_RS08450	COG0512	Glutamine amidotransferase of anthranilate synthase
K6J80_RS08455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6J80_RS08460	COG0134	indole-3-glycerol-phosphate synthase activity
K6J80_RS08460	COG0135	phosphoribosylanthranilate isomerase activity
K6J80_RS08465	COG0133	tryptophan synthase activity
K6J80_RS08470	COG0159	tryptophan synthase activity
K6J80_RS08480	COG1435	thymidine kinase activity
K6J80_RS08485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6J80_RS08490	COG1801	Protein of unknown function DUF72
K6J80_RS08495	COG4106	trans-aconitate 2-methyltransferase activity
K6J80_RS08500	COG0500	methyltransferase
K6J80_RS08505	COG4067	protein conserved in archaea
K6J80_RS08505	COG0189	ligase activity
K6J80_RS08520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6J80_RS08530	COG3852	Histidine kinase
K6J80_RS08545	COG3070	regulator of competence-specific genes
K6J80_RS08555	COG2431	L-lysine efflux transmembrane transporter activity
K6J80_RS08565	COG0076	glutamate decarboxylase activity
K6J80_RS08570	COG1737	Transcriptional regulator
K6J80_RS08575	COG1454	alcohol dehydrogenase
K6J80_RS08575	COG1012	belongs to the aldehyde dehydrogenase family
K6J80_RS08580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6J80_RS08585	COG3273	potassium ion transport
K6J80_RS08585	COG2985	domain, Protein
K6J80_RS08590	COG0542	response to heat
K6J80_RS08595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K6J80_RS08600	COG1278	Cold shock
K6J80_RS08610	COG1187	pseudouridine synthase activity
K6J80_RS08615	COG0140	phosphoribosyl-ATP diphosphatase activity
K6J80_RS08615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6J80_RS08620	COG0107	imidazoleglycerol-phosphate synthase activity
K6J80_RS08625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6J80_RS08635	COG0131	Imidazoleglycerol-phosphate dehydratase
K6J80_RS08635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6J80_RS08640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6J80_RS08645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6J80_RS08650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6J80_RS08655	COG1757	Na H antiporter
K6J80_RS08660	COG2916	Histone family protein nucleoid-structuring protein H-NS
K6J80_RS08665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J80_RS08670	COG0482	sulfurtransferase activity
K6J80_RS08675	COG2915	High frequency lysogenization protein hflD homolog
K6J80_RS08680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6J80_RS08690	COG2268	Band 7 protein
K6J80_RS08700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6J80_RS08715	COG0300	oxidoreductase activity
K6J80_RS08725	COG0501	Belongs to the peptidase M48B family
K6J80_RS08735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6J80_RS08740	COG2226	methyltransferase
K6J80_RS08745	COG0156	8-amino-7-oxononanoate synthase activity
K6J80_RS08750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6J80_RS08755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6J80_RS08760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6J80_RS08765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6J80_RS08770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K6J80_RS08780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6J80_RS08785	COG2203	Gaf domain
K6J80_RS08785	COG2199	diguanylate cyclase activity
K6J80_RS08795	COG4120	Belongs to the binding-protein-dependent transport system permease family
K6J80_RS08805	COG4628	conserved protein (DUF2132)
K6J80_RS08810	COG3092	negative regulation of chromosome organization
K6J80_RS08815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6J80_RS08820	COG0280	phosphate acetyltransferase
K6J80_RS08820	COG0857	belongs to the CobB CobQ family
K6J80_RS08825	COG0435	Glutathione S-transferase
K6J80_RS08830	COG4608	Belongs to the ABC transporter superfamily
K6J80_RS08835	COG0444	Belongs to the ABC transporter superfamily
K6J80_RS08840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J80_RS08865	COG2204	response regulator
K6J80_RS08870	COG3300	MHYT domain
K6J80_RS08870	COG5001	Diguanylate cyclase
K6J80_RS08875	COG4191	Histidine kinase
K6J80_RS08880	COG5002	protein histidine kinase activity
K6J80_RS08890	COG2201	protein-glutamate methylesterase activity
K6J80_RS08905	COG0009	L-threonylcarbamoyladenylate synthase
K6J80_RS08920	COG1881	PFAM PEBP family protein
K6J80_RS08945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6J80_RS08950	COG0640	Transcriptional regulator
K6J80_RS08960	COG3706	GGDEF domain
K6J80_RS08980	COG1946	Acyl-CoA thioesterase
K6J80_RS08985	COG1522	sequence-specific DNA binding
K6J80_RS08995	COG0616	signal peptide processing
K6J80_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
K6J80_RS09005	COG2983	Belongs to the UPF0260 family
K6J80_RS09015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6J80_RS09020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K6J80_RS09030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6J80_RS09035	COG2832	Protein of unknown function (DUF454)
K6J80_RS09040	COG0745	RESPONSE REGULATOR receiver
K6J80_RS09045	COG0583	DNA-binding transcription factor activity
K6J80_RS09050	COG0778	Nitroreductase
K6J80_RS09055	COG1024	Enoyl-CoA hydratase
K6J80_RS09055	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6J80_RS09060	COG0183	Belongs to the thiolase family
K6J80_RS09080	COG2067	long-chain fatty acid transport protein
K6J80_RS09090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6J80_RS09095	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K6J80_RS09100	COG2982	Protein involved in outer membrane biogenesis
K6J80_RS09105	COG0572	uridine kinase
K6J80_RS09110	COG0489	protein tyrosine kinase activity
K6J80_RS09115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J80_RS09115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6J80_RS09125	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6J80_RS09135	COG0517	IMP dehydrogenase activity
K6J80_RS09135	COG0617	tRNA 3'-terminal CCA addition
K6J80_RS09135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6J80_RS09140	COG2199	diguanylate cyclase activity
K6J80_RS09145	COG0314	molybdopterin synthase activity
K6J80_RS09150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6J80_RS09155	COG0315	cyclic pyranopterin monophosphate synthase activity
K6J80_RS09160	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6J80_RS09165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6J80_RS09170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6J80_RS09175	COG2198	Histidine kinase
K6J80_RS09180	COG2204	response regulator
K6J80_RS09185	COG0556	nucleotide-excision repair
K6J80_RS09195	COG4657	Part of a membrane complex involved in electron transport
K6J80_RS09200	COG2878	Part of a membrane complex involved in electron transport
K6J80_RS09205	COG4656	Part of a membrane complex involved in electron transport
K6J80_RS09225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6J80_RS09230	COG0346	lactoylglutathione lyase activity
K6J80_RS09245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6J80_RS09250	COG2056	Na+-H+ antiporter family
K6J80_RS09255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6J80_RS09260	COG1286	toxin biosynthetic process
K6J80_RS09265	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K6J80_RS09270	COG0285	dihydrofolate synthase activity
K6J80_RS09275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6J80_RS09280	COG0101	tRNA pseudouridine synthase activity
K6J80_RS09295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J80_RS09295	COG2190	(PTS) system
K6J80_RS09295	COG1263	PTS System
K6J80_RS09300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6J80_RS09305	COG1846	Transcriptional regulator
K6J80_RS09305	COG1940	carbohydrate kinase activity
K6J80_RS09315	COG0367	asparagine synthase
K6J80_RS09330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6J80_RS09335	COG0563	adenylate kinase activity
K6J80_RS09340	COG0326	Molecular chaperone. Has ATPase activity
K6J80_RS09345	COG3710	Transcriptional regulator
K6J80_RS09360	COG0622	Phosphoesterase
K6J80_RS09365	COG1090	epimerase
K6J80_RS09370	COG0300	oxidoreductase activity
K6J80_RS09375	COG3118	belongs to the thioredoxin family
K6J80_RS09380	COG0330	HflC and HflK could
K6J80_RS09385	COG1585	Membrane protein implicated in regulation of membrane protease activity
K6J80_RS09390	COG0789	Transcriptional regulator
K6J80_RS09405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6J80_RS09410	COG3115	cell septum assembly
K6J80_RS09415	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K6J80_RS09420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6J80_RS09425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J80_RS09435	COG2190	(PTS) system
K6J80_RS09440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6J80_RS09445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6J80_RS09450	COG1702	phosphate starvation-inducible protein PhoH
K6J80_RS09460	COG4535	Mg2 and Co2 transporter CorC
K6J80_RS09465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K6J80_RS09470	COG2888	peptidyl-tyrosine sulfation
K6J80_RS09475	COG0495	leucyl-tRNA aminoacylation
K6J80_RS09480	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K6J80_RS09485	COG1466	dna polymerase III delta subunit
K6J80_RS09490	COG0799	negative regulation of ribosome biogenesis
K6J80_RS09495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6J80_RS09500	COG0768	penicillin binding
K6J80_RS09505	COG0772	Belongs to the SEDS family
K6J80_RS09510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6J80_RS09515	COG1686	Belongs to the peptidase S11 family
K6J80_RS09520	COG2921	Belongs to the UPF0250 family
K6J80_RS09525	COG0321	lipoyl(octanoyl) transferase activity
K6J80_RS09540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6J80_RS09565	COG1596	polysaccharide export
K6J80_RS09575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6J80_RS09605	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K6J80_RS09615	COG0438	transferase activity, transferring glycosyl groups
K6J80_RS09625	COG1045	serine acetyltransferase
K6J80_RS09645	COG0110	maltose O-acetyltransferase activity
K6J80_RS09650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K6J80_RS09655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6J80_RS09660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6J80_RS09695	COG0366	Alpha amylase catalytic
K6J80_RS09700	COG1263	PTS System
K6J80_RS09700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J80_RS09705	COG1609	Transcriptional regulator
K6J80_RS09710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6J80_RS09715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6J80_RS09720	COG2011	ABC-type metal ion transport system permease component
K6J80_RS09725	COG1464	Belongs to the NlpA lipoprotein family
K6J80_RS09730	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K6J80_RS09740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6J80_RS09740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6J80_RS09755	COG1611	Belongs to the LOG family
K6J80_RS09765	COG2363	Small membrane protein
K6J80_RS09770	COG0583	DNA-binding transcription factor activity
K6J80_RS09775	COG0301	tRNA thio-modification
K6J80_RS09775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6J80_RS09785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6J80_RS09790	COG1722	exodeoxyribonuclease VII activity
K6J80_RS09795	COG0142	geranyltranstransferase activity
K6J80_RS09800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6J80_RS09805	COG0564	pseudouridine synthase activity
K6J80_RS09810	COG3098	single-species biofilm formation
K6J80_RS09825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J80_RS09835	COG1671	Belongs to the UPF0178 family
K6J80_RS09845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6J80_RS09850	COG0254	rRNA binding
K6J80_RS09855	COG1720	tRNA m6t6A37 methyltransferase activity
K6J80_RS09860	COG0442	prolyl-tRNA aminoacylation
K6J80_RS09885	COG0047	phosphoribosylformylglycinamidine synthase activity
K6J80_RS09885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6J80_RS09895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K6J80_RS09905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K6J80_RS09935	COG0484	heat shock protein binding
K6J80_RS09940	COG0443	Heat shock 70 kDa protein
K6J80_RS09950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6J80_RS09955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6J80_RS09960	COG0497	DNA recombination
K6J80_RS09965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6J80_RS09970	COG2914	Belongs to the UPF0125 (RnfH) family
K6J80_RS09975	COG2867	negative regulation of translational initiation
K6J80_RS09980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6J80_RS09990	COG0582	viral genome integration into host DNA
K6J80_RS10005	COG3064	Membrane
K6J80_RS10015	COG0739	heme binding
K6J80_RS10035	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K6J80_RS10040	COG2207	Transcriptional regulator
K6J80_RS10050	COG1459	type II secretion system
K6J80_RS10055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J80_RS10075	COG4796	Type ii and iii secretion system protein
K6J80_RS10090	COG2165	general secretion pathway protein
K6J80_RS10100	COG3710	Transcriptional regulator
K6J80_RS10105	COG0840	transmembrane signaling receptor activity
K6J80_RS10110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6J80_RS10130	COG1012	belongs to the aldehyde dehydrogenase family
K6J80_RS10185	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K6J80_RS10190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K6J80_RS10195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6J80_RS10215	COG3051	citrate lyase alpha subunit
K6J80_RS10220	COG2301	Belongs to the HpcH HpaI aldolase family
K6J80_RS10230	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K6J80_RS10240	COG3630	sodium ion export across plasma membrane
K6J80_RS10245	COG0511	ligase activity, forming carbon-carbon bonds
K6J80_RS10245	COG5016	pyruvate
K6J80_RS10250	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6J80_RS10260	COG4565	transcriptional regulatory protein
K6J80_RS10275	COG0583	DNA-binding transcription factor activity
K6J80_RS10285	COG1115	amino acid carrier protein
K6J80_RS10290	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K6J80_RS10295	COG0583	DNA-binding transcription factor activity
K6J80_RS10305	COG1120	ATPase activity
K6J80_RS10310	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J80_RS10315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J80_RS10320	COG4592	Periplasmic binding protein
K6J80_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
K6J80_RS10335	COG1169	isochorismate synthase
K6J80_RS10340	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6J80_RS10345	COG1535	isochorismatase
K6J80_RS10345	COG3433	isochorismatase activity
K6J80_RS10350	COG1584	GPR1 FUN34 yaaH family protein
K6J80_RS10360	COG0519	Catalyzes the synthesis of GMP from XMP
K6J80_RS10360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6J80_RS10365	COG0517	IMP dehydrogenase activity
K6J80_RS10365	COG0516	GMP reductase activity
K6J80_RS10370	COG1570	exodeoxyribonuclease VII activity
K6J80_RS10385	COG1160	GTP binding
K6J80_RS10390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6J80_RS10395	COG2976	Protein conserved in bacteria
K6J80_RS10400	COG0124	histidyl-tRNA synthetase
K6J80_RS10405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6J80_RS10415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6J80_RS10420	COG0105	UTP biosynthetic process
K6J80_RS10425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6J80_RS10430	COG2975	iron-sulfur cluster assembly
K6J80_RS10435	COG0633	Ferredoxin
K6J80_RS10440	COG0443	Heat shock 70 kDa protein
K6J80_RS10445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6J80_RS10455	COG0822	iron-sulfur transferase activity
K6J80_RS10460	COG1104	cysteine desulfurase activity
K6J80_RS10465	COG1959	2 iron, 2 sulfur cluster binding
K6J80_RS10475	COG0483	inositol monophosphate 1-phosphatase activity
K6J80_RS10480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J80_RS10485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J80_RS10490	COG1862	Preprotein translocase
K6J80_RS10505	COG0517	IMP dehydrogenase activity
K6J80_RS10515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6J80_RS10520	COG0583	DNA-binding transcription factor activity
K6J80_RS10525	COG0450	alkyl hydroperoxide reductase
K6J80_RS10530	COG3142	Participates in the control of copper homeostasis
K6J80_RS10545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6J80_RS10550	COG0581	inorganic phosphate transmembrane transporter activity
K6J80_RS10560	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6J80_RS10565	COG0248	Ppx GppA phosphatase
K6J80_RS10575	COG5002	protein histidine kinase activity
K6J80_RS10580	COG0745	RESPONSE REGULATOR receiver
K6J80_RS10590	COG0826	peptidase U32
K6J80_RS10595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6J80_RS10635	COG0542	response to heat
K6J80_RS10645	COG0564	pseudouridine synthase activity
K6J80_RS10650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6J80_RS10655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6J80_RS10660	COG0077	Prephenate dehydratase
K6J80_RS10660	COG1605	Chorismate mutase
K6J80_RS10665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6J80_RS10680	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K6J80_RS10690	COG0488	(ABC) transporter
K6J80_RS10700	COG0287	Prephenate dehydrogenase
K6J80_RS10700	COG1605	Chorismate mutase
K6J80_RS10705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6J80_RS10710	COG3275	phosphorelay sensor kinase activity
K6J80_RS10715	COG3279	Response regulator of the LytR AlgR family
K6J80_RS10725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6J80_RS10730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6J80_RS10745	COG1966	Carbon starvation protein
K6J80_RS10750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6J80_RS10770	COG0196	riboflavin kinase activity
K6J80_RS10775	COG0728	peptidoglycan biosynthetic process
K6J80_RS10780	COG0268	Binds directly to 16S ribosomal RNA
K6J80_RS10785	COG0640	Transcriptional regulator
K6J80_RS10790	COG0583	DNA-binding transcription factor activity
K6J80_RS10795	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6J80_RS10805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6J80_RS10810	COG0730	response to heat
K6J80_RS10820	COG0494	nUDIX hydrolase
K6J80_RS10830	COG0667	Aldo Keto reductase
K6J80_RS10840	COG2204	response regulator
K6J80_RS10845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6J80_RS10865	COG0513	Belongs to the DEAD box helicase family
K6J80_RS10980	COG2003	Belongs to the UPF0758 family
K6J80_RS11005	COG0714	Associated with various cellular activities
K6J80_RS11025	COG0629	single-stranded DNA binding
K6J80_RS11040	COG2356	endonuclease I
K6J80_RS11080	COG0681	Belongs to the peptidase S26 family
K6J80_RS11095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6J80_RS11225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6J80_RS11240	COG3328	transposase activity
K6J80_RS11355	COG3153	acetyltransferase
K6J80_RS11360	COG3154	lipid carrier protein
K6J80_RS11370	COG0826	peptidase U32
K6J80_RS11375	COG0826	peptidase U32
K6J80_RS11400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6J80_RS11410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6J80_RS11415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6J80_RS11420	COG0195	Participates in both transcription termination and antitermination
K6J80_RS11425	COG0779	Required for maturation of 30S ribosomal subunits
K6J80_RS11440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6J80_RS11450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6J80_RS11455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6J80_RS11460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K6J80_RS11465	COG1534	Rna-binding protein
K6J80_RS11470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6J80_RS11475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6J80_RS11480	COG2027	D-alanyl-D-alanine carboxypeptidase
K6J80_RS11485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6J80_RS11490	COG0739	heme binding
K6J80_RS11505	COG0316	Belongs to the HesB IscA family
K6J80_RS11510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6J80_RS11515	COG0628	permease
K6J80_RS11525	COG0784	Response regulator, receiver
K6J80_RS11525	COG2205	protein histidine kinase activity
K6J80_RS11530	COG0747	negative chemotaxis
K6J80_RS11535	COG0601	transmembrane transport
K6J80_RS11540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J80_RS11545	COG0444	Belongs to the ABC transporter superfamily
K6J80_RS11550	COG4608	Belongs to the ABC transporter superfamily
K6J80_RS11560	COG2971	BadF BadG BcrA BcrD
K6J80_RS11580	COG3842	ATPase activity
K6J80_RS11590	COG1840	ABC-type Fe3 transport system, periplasmic component
K6J80_RS11595	COG0004	ammonium transporteR
K6J80_RS11600	COG0347	Belongs to the P(II) protein family
K6J80_RS11605	COG3112	Uncharacterised protein family (UPF0231)
K6J80_RS11615	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6J80_RS11620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6J80_RS11625	COG1643	Atp-dependent helicase
K6J80_RS11635	COG1489	DNA binding
K6J80_RS11645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6J80_RS11655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6J80_RS11660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6J80_RS11665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6J80_RS11670	COG0842	Transport permease protein
K6J80_RS11680	COG0659	secondary active sulfate transmembrane transporter activity
K6J80_RS11685	COG0288	reversible hydration of carbon dioxide
K6J80_RS11700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6J80_RS11705	COG3107	peptidoglycan biosynthetic process
K6J80_RS11710	COG0792	nuclease activity
K6J80_RS11715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K6J80_RS11720	COG2823	Periplasmic or secreted lipoprotein
K6J80_RS11725	COG2969	positive regulation of protein catabolic process
K6J80_RS11730	COG0625	glutathione transferase activity
K6J80_RS11735	COG2857	Cytochrome c1
K6J80_RS11740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6J80_RS11745	COG0723	plastoquinol--plastocyanin reductase activity
K6J80_RS11750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6J80_RS11755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6J80_RS11760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K6J80_RS11770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6J80_RS11775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6J80_RS11780	COG0335	large ribosomal subunit rRNA binding
K6J80_RS11785	COG0336	Belongs to the RNA methyltransferase TrmD family
K6J80_RS11790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6J80_RS11795	COG0228	four-way junction DNA binding
K6J80_RS11800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6J80_RS11805	COG4137	Cytochrome C assembly protein
K6J80_RS11810	COG4536	flavin adenine dinucleotide binding
K6J80_RS11815	COG1854	S-ribosylhomocysteine lyase activity
K6J80_RS11820	COG2918	glutathione biosynthetic process
K6J80_RS11825	COG0612	Peptidase, M16
K6J80_RS11830	COG1238	metal cluster binding
K6J80_RS11840	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K6J80_RS11845	COG0511	ligase activity, forming carbon-carbon bonds
K6J80_RS11845	COG5016	pyruvate
K6J80_RS11850	COG3630	sodium ion export across plasma membrane
K6J80_RS11895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K6J80_RS11900	COG0527	aspartate kinase activity
K6J80_RS11905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6J80_RS11915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6J80_RS11925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K6J80_RS11930	COG4208	sulfate ABC transporter
K6J80_RS11950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6J80_RS11955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6J80_RS11965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K6J80_RS11970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K6J80_RS11975	COG0585	pseudouridine synthase activity
K6J80_RS11980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6J80_RS11985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6J80_RS11990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6J80_RS11995	COG1968	undecaprenyl-diphosphatase activity
K6J80_RS12000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6J80_RS12005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6J80_RS12010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6J80_RS12025	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6J80_RS12030	COG1610	YqeY-like protein
K6J80_RS12035	COG0358	DNA primase activity
K6J80_RS12050	COG0582	viral genome integration into host DNA
K6J80_RS12065	COG2207	Transcriptional regulator
K6J80_RS12110	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K6J80_RS12115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6J80_RS12120	COG1349	DNA-binding transcription factor activity
K6J80_RS12140	COG1279	arginine transmembrane transporter activity
K6J80_RS12145	COG0668	transmembrane transport
K6J80_RS12150	COG0191	fructose-bisphosphate aldolase activity
K6J80_RS12155	COG0126	phosphoglycerate kinase activity
K6J80_RS12160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6J80_RS12165	COG4771	TonB-dependent receptor
K6J80_RS12170	COG0583	DNA-binding transcription factor activity
K6J80_RS12175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6J80_RS12180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6J80_RS12190	COG2356	endonuclease I
K6J80_RS12195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6J80_RS12200	COG0189	ligase activity
K6J80_RS12205	COG1678	Uncharacterized ACR, COG1678
K6J80_RS12210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6J80_RS12215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6J80_RS12235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6J80_RS12240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6J80_RS12245	COG0762	integral membrane protein
K6J80_RS12250	COG1872	DUF167
K6J80_RS12260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6J80_RS12265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6J80_RS12270	COG2066	Belongs to the glutaminase family
K6J80_RS12280	COG1194	a g-specific adenine glycosylase
K6J80_RS12285	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K6J80_RS12290	COG0741	lytic transglycosylase activity
K6J80_RS12345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K6J80_RS12350	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K6J80_RS12355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6J80_RS12360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K6J80_RS12365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6J80_RS12370	COG2967	ApaG domain
K6J80_RS12375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6J80_RS12385	COG3610	response to peptide
K6J80_RS12390	COG2966	Psort location CytoplasmicMembrane, score
K6J80_RS12400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6J80_RS12405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6J80_RS12410	COG0142	geranyltranstransferase activity
K6J80_RS12420	COG0039	L-malate dehydrogenase activity
K6J80_RS12425	COG1438	arginine binding
K6J80_RS12430	COG2358	TRAP transporter, solute receptor (TAXI family
K6J80_RS12440	COG0589	response to stress
K6J80_RS12460	COG2235	arginine
K6J80_RS12465	COG0312	modulator of DNA gyrase
K6J80_RS12470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6J80_RS12475	COG3164	Protein of unknown function
K6J80_RS12485	COG0424	maF-like protein
K6J80_RS12490	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6J80_RS12495	COG1792	Involved in formation and maintenance of cell shape
K6J80_RS12500	COG1077	Cell shape determining protein MreB Mrl
K6J80_RS12530	COG2165	general secretion pathway protein
K6J80_RS12535	COG2165	general secretion pathway protein
K6J80_RS12545	COG1459	type II secretion system
K6J80_RS12550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6J80_RS12560	COG3409	Peptidoglycan-binding domain 1 protein
K6J80_RS12560	COG3267	Type II secretory pathway component ExeA
K6J80_RS12585	COG2199	diguanylate cyclase activity
K6J80_RS12585	COG2200	EAL domain
K6J80_RS12590	COG0629	single-stranded DNA binding
K6J80_RS12605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6J80_RS12615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6J80_RS12620	COG0527	aspartate kinase activity
K6J80_RS12625	COG0646	methionine synthase
K6J80_RS12625	COG1410	methionine synthase
K6J80_RS12695	COG0175	sulfate reduction
K6J80_RS12705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6J80_RS12730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6J80_RS12735	COG0735	belongs to the Fur family
K6J80_RS12755	COG0432	Pfam Uncharacterised protein family UPF0047
K6J80_RS12760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6J80_RS12775	COG0359	binds to the 23S rRNA
K6J80_RS12780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6J80_RS12785	COG2965	DNA replication, synthesis of RNA primer
K6J80_RS12790	COG0360	Binds together with S18 to 16S ribosomal RNA
K6J80_RS12800	COG2906	2 iron, 2 sulfur cluster binding
K6J80_RS12805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6J80_RS12810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6J80_RS12815	COG0049	tRNA binding
K6J80_RS12830	COG2923	Belongs to the DsrF TusC family
K6J80_RS12835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K6J80_RS12840	COG2964	Protein conserved in bacteria
K6J80_RS12845	COG0545	Peptidyl-prolyl cis-trans isomerase
K6J80_RS12855	COG2900	Belongs to the SlyX family
K6J80_RS12860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K6J80_RS12865	COG0330	HflC and HflK could
K6J80_RS12870	COG0330	HflC and HflK could
K6J80_RS12875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6J80_RS12880	COG1923	regulation of RNA biosynthetic process
K6J80_RS12885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6J80_RS12890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6J80_RS12900	COG0802	atpase or kinase
K6J80_RS12905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6J80_RS12950	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K6J80_RS12955	COG1162	GTPase activity
K6J80_RS12960	COG0688	phosphatidylethanolamine metabolic process
K6J80_RS12965	COG0471	metal ion transport
K6J80_RS12975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6J80_RS12980	COG4942	peptidase
K6J80_RS12995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6J80_RS13000	COG2816	NAD+ diphosphatase activity
K6J80_RS13005	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K6J80_RS13015	COG0085	RNA polymerase activity
K6J80_RS13020	COG0222	ribosome binding
K6J80_RS13025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6J80_RS13035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6J80_RS13040	COG0250	Participates in transcription elongation, termination and antitermination
K6J80_RS13045	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6J80_RS13050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6J80_RS13075	COG1072	(Pantothenic acid kinase))
K6J80_RS13085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6J80_RS13095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6J80_RS13140	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6J80_RS13155	COG3118	belongs to the thioredoxin family
K6J80_RS13165	COG0248	Ppx GppA phosphatase
K6J80_RS13170	COG0784	Response regulator, receiver
K6J80_RS13170	COG2205	protein histidine kinase activity
K6J80_RS13175	COG2814	Major facilitator Superfamily
K6J80_RS13190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6J80_RS13195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6J80_RS13200	COG0511	ligase activity, forming carbon-carbon bonds
K6J80_RS13205	COG0439	Biotin carboxylase
K6J80_RS13210	COG2264	protein methyltransferase activity
K6J80_RS13215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6J80_RS13220	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K6J80_RS13230	COG0129	dihydroxy-acid dehydratase activity
K6J80_RS13235	COG3265	gluconokinase activity
K6J80_RS13245	COG0800	Aldolase
K6J80_RS13265	COG0840	transmembrane signaling receptor activity
K6J80_RS13270	COG1982	Orn Lys Arg decarboxylase major
K6J80_RS13275	COG0531	amino acid
K6J80_RS13280	COG3710	Transcriptional regulator
K6J80_RS13285	COG0789	Transcriptional regulator
K6J80_RS13300	COG0151	Belongs to the GarS family
K6J80_RS13310	COG0776	regulation of translation
K6J80_RS13315	COG1253	flavin adenine dinucleotide binding
K6J80_RS13320	COG1940	carbohydrate kinase activity
K6J80_RS13330	COG3068	Protein conserved in bacteria
K6J80_RS13340	COG1573	uracil-dna glycosylase
K6J80_RS13345	COG0668	transmembrane transport
K6J80_RS13350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K6J80_RS13355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6J80_RS13400	COG1454	alcohol dehydrogenase
K6J80_RS13400	COG1012	belongs to the aldehyde dehydrogenase family
K6J80_RS13405	COG0318	PFAM AMP-dependent synthetase and ligase
K6J80_RS13435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K6J80_RS13440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6J80_RS13445	COG0662	Cupin 2, conserved barrel domain protein
K6J80_RS13445	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K6J80_RS13450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6J80_RS13485	COG1519	Transferase
K6J80_RS13515	COG3642	lipopolysaccharide core region biosynthetic process
K6J80_RS13520	COG0859	PFAM glycosyl transferase family 9
K6J80_RS13525	COG0463	Glycosyl transferase, family 2
K6J80_RS13530	COG0859	PFAM glycosyl transferase family 9
K6J80_RS13535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6J80_RS13540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6J80_RS13550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6J80_RS13555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6J80_RS13560	COG2003	Belongs to the UPF0758 family
K6J80_RS13570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6J80_RS13580	COG1309	transcriptional regulator
K6J80_RS13585	COG1560	Kdo2-lipid A biosynthetic process
K6J80_RS13590	COG1560	Kdo2-lipid A biosynthetic process
K6J80_RS13595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6J80_RS13600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6J80_RS13605	COG1561	YicC-like family, N-terminal region
K6J80_RS13610	COG2862	Uncharacterized protein family, UPF0114
K6J80_RS13620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6J80_RS13640	COG1120	ATPase activity
K6J80_RS13645	COG4774	siderophore transport
K6J80_RS13650	COG1132	(ABC) transporter
K6J80_RS13665	COG0514	ATP-dependent DNA helicase (RecQ)
K6J80_RS13670	COG2962	Rard protein
K6J80_RS13690	COG0210	DNA helicase
K6J80_RS13695	COG0339	signal peptide processing
K6J80_RS13700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K6J80_RS13705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6J80_RS13745	COG3621	Patatin-like phospholipase
K6J80_RS13775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J80_RS13780	COG0601	transmembrane transport
K6J80_RS13785	COG0747	negative chemotaxis
K6J80_RS13835	COG1309	transcriptional regulator
K6J80_RS13840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6J80_RS13845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6J80_RS13850	COG2960	long-chain fatty acid transporting porin activity
K6J80_RS13855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6J80_RS13860	COG0583	DNA-binding transcription factor activity
K6J80_RS13905	COG3621	Patatin-like phospholipase
K6J80_RS13930	COG2131	deaminase
K6J80_RS13940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J80_RS13945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6J80_RS13955	COG0183	Belongs to the thiolase family
K6J80_RS13965	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6J80_RS13970	COG3842	ATPase activity
K6J80_RS13980	COG1840	ABC-type Fe3 transport system, periplasmic component
K6J80_RS13995	COG2197	response regulator
K6J80_RS14000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6J80_RS14020	COG0243	molybdopterin cofactor binding
K6J80_RS14030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K6J80_RS14035	COG3850	Histidine kinase
K6J80_RS14040	COG2197	response regulator
K6J80_RS14045	COG1609	Transcriptional regulator
K6J80_RS14065	COG1760	l-serine dehydratase
K6J80_RS14070	COG3069	C4-dicarboxylate transmembrane transporter activity
K6J80_RS14075	COG0840	transmembrane signaling receptor activity
K6J80_RS14080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6J80_RS14085	COG0545	Peptidyl-prolyl cis-trans isomerase
K6J80_RS14090	COG2885	chlorophyll binding
K6J80_RS14100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6J80_RS14105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J80_RS14110	COG1621	beta-fructofuranosidase activity
K6J80_RS14115	COG1609	Transcriptional regulator
K6J80_RS14120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6J80_RS14120	COG1263	PTS System
K6J80_RS14165	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6J80_RS14205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6J80_RS14210	COG0583	DNA-binding transcription factor activity
K6J80_RS14235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6J80_RS14260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6J80_RS14275	COG2897	thiosulfate sulfurtransferase activity
K6J80_RS14285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6J80_RS14295	COG0302	gtp cyclohydrolase
K6J80_RS14300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J80_RS14300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6J80_RS14305	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K6J80_RS14310	COG1970	mechanosensitive ion channel activity
K6J80_RS14315	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K6J80_RS14330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6J80_RS14335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6J80_RS14340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6J80_RS14345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6J80_RS14355	COG3842	ATPase activity
K6J80_RS14375	COG3104	oligopeptide transport
K6J80_RS14400	COG4166	transmembrane transport
K6J80_RS14405	COG4174	ABC transporter (Permease)
K6J80_RS14410	COG4239	(ABC) transporter, permease
K6J80_RS14415	COG4172	Belongs to the ABC transporter superfamily
K6J80_RS14420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6J80_RS14435	COG0625	glutathione transferase activity
K6J80_RS14455	COG2050	protein possibly involved in aromatic compounds catabolism
K6J80_RS14470	COG4771	TonB-dependent receptor
K6J80_RS14470	COG1629	transport
K6J80_RS14475	COG0583	DNA-binding transcription factor activity
K6J80_RS14480	COG1042	CoA-binding domain protein
K6J80_RS14480	COG0045	succinate-CoA ligase (ADP-forming) activity
K6J80_RS14480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J80_RS14500	COG0023	Translation Initiation Factor
K6J80_RS14505	COG3140	Belongs to the UPF0181 family
K6J80_RS14520	COG0745	RESPONSE REGULATOR receiver
K6J80_RS14530	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K6J80_RS14535	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K6J80_RS14550	COG3706	GGDEF domain
K6J80_RS14570	COG2199	diguanylate cyclase activity
K6J80_RS14600	COG2824	Alkylphosphonate utilization operon protein PhnA
K6J80_RS14615	COG0737	Belongs to the 5'-nucleotidase family
K6J80_RS14630	COG0583	DNA-binding transcription factor activity
K6J80_RS14635	COG2116	formate transmembrane transporter activity
K6J80_RS14645	COG3038	cytochrome b561
K6J80_RS14655	COG2200	EAL domain
K6J80_RS14665	COG0586	Pfam SNARE associated Golgi protein
K6J80_RS14670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6J80_RS14675	COG0745	RESPONSE REGULATOR receiver
K6J80_RS14680	COG2205	protein histidine kinase activity
K6J80_RS14685	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6J80_RS14685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6J80_RS14685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6J80_RS14685	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6J80_RS14700	COG0523	cobalamin synthesis protein
K6J80_RS14715	COG0156	8-amino-7-oxononanoate synthase activity
K6J80_RS14720	COG0784	Response regulator, receiver
K6J80_RS14720	COG2205	protein histidine kinase activity
K6J80_RS14725	COG0419	ATPase involved in DNA repair
K6J80_RS14730	COG0420	3'-5' exonuclease activity
K6J80_RS14735	COG1609	Transcriptional regulator
K6J80_RS14740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J80_RS14740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J80_RS14745	COG1105	Belongs to the carbohydrate kinase PfkB family
K6J80_RS14755	COG4067	protein conserved in archaea
K6J80_RS14755	COG0189	ligase activity
K6J80_RS14765	COG0602	queuosine metabolic process
K6J80_RS14770	COG1328	CTP reductase activity
K6J80_RS14785	COG0346	lactoylglutathione lyase activity
K6J80_RS14930	COG0346	lactoylglutathione lyase activity
K6J80_RS14950	COG3039	Transposase
K6J80_RS14965	COG2944	sequence-specific DNA binding
K6J80_RS14970	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
K6J80_RS15050	COG4977	sequence-specific DNA binding
K6J80_RS15105	COG3040	lipid binding
K6J80_RS15125	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6J80_RS15140	COG3093	addiction module antidote protein HigA
K6J80_RS15145	COG3549	Plasmid maintenance system killer
K6J80_RS15330	COG1280	lysine exporter protein (LysE YggA)
K6J80_RS15340	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6J80_RS15355	COG3040	lipid binding
K6J80_RS15370	COG0346	lactoylglutathione lyase activity
K6J80_RS15420	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6J80_RS15510	COG3041	Addiction module toxin RelE StbE family
K6J80_RS15540	COG3040	lipid binding
K6J80_RS15545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J80_RS15560	COG0494	nUDIX hydrolase
K6J80_RS15585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K6J80_RS15620	COG1028	Short-chain dehydrogenase reductase Sdr
K6J80_RS15665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6J80_RS15670	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6J80_RS15705	COG3039	Transposase
K6J80_RS15715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6J80_RS15725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6J80_RS15730	COG0509	glycine decarboxylation via glycine cleavage system
K6J80_RS15735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6J80_RS15735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6J80_RS15760	COG1686	Belongs to the peptidase S11 family
K6J80_RS15775	COG2814	Major facilitator Superfamily
K6J80_RS15790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6J80_RS15815	COG5002	protein histidine kinase activity
K6J80_RS15820	COG0745	RESPONSE REGULATOR receiver
K6J80_RS15845	COG0366	Alpha amylase catalytic
K6J80_RS15850	COG3038	cytochrome b561
K6J80_RS15880	COG0561	phosphatase activity
K6J80_RS15885	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K6J80_RS15890	COG3623	hexulose-6-phosphate isomerase
K6J80_RS15900	COG0745	RESPONSE REGULATOR receiver
K6J80_RS15920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6J80_RS15935	COG2207	Transcriptional regulator
K6J80_RS15940	COG4604	ABC transporter, ATP-binding protein
K6J80_RS15945	COG4605	iron ion homeostasis
K6J80_RS15950	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J80_RS15975	COG5380	lipid catabolic process
K6J80_RS15980	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6J80_RS15985	COG0840	transmembrane signaling receptor activity
K6J80_RS15995	COG3240	lipase activity
K6J80_RS16000	COG3706	GGDEF domain
K6J80_RS16010	COG2814	Major facilitator Superfamily
K6J80_RS16015	COG1757	Na H antiporter
K6J80_RS16025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J80_RS16025	COG4191	Histidine kinase
K6J80_RS16030	COG3437	response regulator, receiver
K6J80_RS16030	COG0784	Response regulator, receiver
K6J80_RS16035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6J80_RS16040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6J80_RS16045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6J80_RS16050	COG0513	Belongs to the DEAD box helicase family
K6J80_RS16105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6J80_RS16110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K6J80_RS16110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6J80_RS16135	COG3036	rescue of stalled ribosome
K6J80_RS16140	COG1278	Cold shock
K6J80_RS16145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6J80_RS16145	COG1017	nitric oxide dioxygenase activity
K6J80_RS16150	COG3604	Transcriptional regulator
K6J80_RS16160	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6J80_RS16165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6J80_RS16180	COG0840	transmembrane signaling receptor activity
K6J80_RS16185	COG0714	Associated with various cellular activities
K6J80_RS16205	COG2304	oxidoreductase activity
K6J80_RS16220	COG1278	Cold shock
K6J80_RS16225	COG5001	Diguanylate cyclase
K6J80_RS16225	COG5002	protein histidine kinase activity
K6J80_RS16235	COG3530	Putative quorum-sensing-regulated virulence factor
K6J80_RS16250	COG0814	amino acid
K6J80_RS16255	COG0589	response to stress
K6J80_RS16265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6J80_RS16265	COG2111	Na H antiporter
K6J80_RS16270	COG1006	Multisubunit Na H antiporter MnhC subunit
K6J80_RS16280	COG1863	multisubunit Na H antiporter MnhE subunit
K6J80_RS16285	COG2212	antiporter activity
K6J80_RS16290	COG1320	monovalent cation:proton antiporter activity
K6J80_RS16300	COG0242	peptide deformylase activity
K6J80_RS16310	COG0579	oxidoreductase
K6J80_RS16345	COG2271	Major facilitator Superfamily
K6J80_RS16350	COG0584	glycerophosphoryl diester phosphodiesterase
K6J80_RS16360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K6J80_RS16370	COG1609	Transcriptional regulator
K6J80_RS16375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J80_RS16380	COG1879	ABC-type sugar transport system periplasmic component
K6J80_RS16385	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6J80_RS16390	COG1129	ABC transporter
K6J80_RS16395	COG1869	D-ribose catabolic process
K6J80_RS16410	COG3409	Peptidoglycan-binding domain 1 protein
K6J80_RS16410	COG3501	Rhs element vgr protein
K6J80_RS16435	COG3829	transcription factor binding
K6J80_RS16500	COG0564	pseudouridine synthase activity
K6J80_RS16510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6J80_RS16515	COG2200	EAL domain
K6J80_RS16515	COG2771	luxR family
K6J80_RS16525	COG0673	inositol 2-dehydrogenase activity
K6J80_RS16530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6J80_RS16560	COG1342	Belongs to the UPF0251 family
K6J80_RS16570	COG1301	dicarboxylic acid transport
K6J80_RS16590	COG2814	Major facilitator Superfamily
K6J80_RS16595	COG0583	DNA-binding transcription factor activity
K6J80_RS16600	COG5001	Diguanylate cyclase
K6J80_RS16600	COG3300	MHYT domain
K6J80_RS16605	COG0739	heme binding
K6J80_RS16615	COG0659	secondary active sulfate transmembrane transporter activity
K6J80_RS16620	COG3314	Sporulation integral membrane protein YlbJ
K6J80_RS16635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6J80_RS16640	COG0581	inorganic phosphate transmembrane transporter activity
K6J80_RS16645	COG0573	inorganic phosphate transmembrane transporter activity
K6J80_RS16650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6J80_RS16680	COG1770	oligopeptidase
K6J80_RS16685	COG0513	Belongs to the DEAD box helicase family
K6J80_RS16695	COG1376	ErfK ybiS ycfS ynhG family protein
K6J80_RS16695	COG1388	LysM domain
K6J80_RS16700	COG0415	Belongs to the DNA photolyase family
K6J80_RS16710	COG3272	Protein of unknown function (DUF1722)
K6J80_RS16715	COG0813	purine-nucleoside phosphorylase activity
K6J80_RS16740	COG1566	PFAM secretion protein HlyD family protein
K6J80_RS16760	COG0786	glutamate:sodium symporter activity
K6J80_RS16775	COG1999	signal sequence binding
K6J80_RS16785	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K6J80_RS16790	COG0671	phosphoesterase, PA-phosphatase related
K6J80_RS16830	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K6J80_RS16835	COG0471	metal ion transport
K6J80_RS16865	COG4104	PAAR repeat-containing protein
K6J80_RS16870	COG3501	Rhs element vgr protein
K6J80_RS16880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6J80_RS16885	COG1640	4-alpha-glucanotransferase
K6J80_RS16890	COG0058	SHG alpha-glucan phosphorylase activity
K6J80_RS16895	COG2909	trisaccharide binding
K6J80_RS16910	COG2084	Dehydrogenase
K6J80_RS16915	COG0217	transcriptional regulatory protein
K6J80_RS16950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6J80_RS16955	COG1444	tRNA N-acetyltransferase activity
K6J80_RS16990	COG0642	Histidine kinase
K6J80_RS16995	COG2194	sulfuric ester hydrolase activity
K6J80_RS17005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6J80_RS17010	COG0601	transmembrane transport
K6J80_RS17030	COG0643	Histidine kinase
K6J80_RS17030	COG2198	Histidine kinase
K6J80_RS17035	COG0835	chemotaxis
K6J80_RS17040	COG0835	chemotaxis
K6J80_RS17045	COG0840	transmembrane signaling receptor activity
K6J80_RS17050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6J80_RS17075	COG0745	RESPONSE REGULATOR receiver
K6J80_RS17115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6J80_RS17140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6J80_RS17170	COG1982	Orn Lys Arg decarboxylase major
K6J80_RS17175	COG0531	amino acid
K6J80_RS17190	COG1901	pseudouridine methyltransferase
K6J80_RS17200	COG4221	oxidoreductase activity
K6J80_RS17205	COG0840	transmembrane signaling receptor activity
K6J80_RS17215	COG2910	NAD(P)H-binding
K6J80_RS17245	COG0673	inositol 2-dehydrogenase activity
K6J80_RS17250	COG3722	fumarate hydratase activity
K6J80_RS17255	COG0246	Mannitol dehydrogenase
K6J80_RS17260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6J80_RS17260	COG2213	PTS system mannitol-specific
K6J80_RS17265	COG0739	heme binding
K6J80_RS17275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6J80_RS17280	COG4597	amino acid ABC transporter
K6J80_RS17285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J80_RS17295	COG1126	abc transporter atp-binding protein
K6J80_RS17300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K6J80_RS17310	COG0840	transmembrane signaling receptor activity
K6J80_RS17325	COG0840	transmembrane signaling receptor activity
K6J80_RS17340	COG4580	involved in the transport of maltose and maltodextrins
K6J80_RS17355	COG0363	glucosamine-6-phosphate deaminase activity
K6J80_RS17380	COG2259	Doxx family
K6J80_RS17385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K6J80_RS17390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6J80_RS17400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6J80_RS17405	COG3366	ferrous iron transmembrane transporter activity
K6J80_RS17410	COG0700	Nucleoside recognition
K6J80_RS17420	COG0697	spore germination
K6J80_RS17425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K6J80_RS17430	COG1764	response to oxidative stress
K6J80_RS17435	COG1846	Transcriptional regulator
K6J80_RS17455	COG2207	Transcriptional regulator
K6J80_RS17460	COG1280	lysine exporter protein (LysE YggA)
K6J80_RS17470	COG1902	pentaerythritol trinitrate reductase activity
K6J80_RS17490	COG1902	pentaerythritol trinitrate reductase activity
K6J80_RS17500	COG0583	DNA-binding transcription factor activity
K6J80_RS17505	COG0513	Belongs to the DEAD box helicase family
K6J80_RS17515	COG0840	transmembrane signaling receptor activity
K6J80_RS17525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6J80_RS17540	COG1620	l-lactate permease
K6J80_RS17550	COG0583	DNA-binding transcription factor activity
K6J80_RS17575	COG4172	Belongs to the ABC transporter superfamily
K6J80_RS17585	COG1067	ATP-dependent peptidase activity
K6J80_RS17590	COG0840	transmembrane signaling receptor activity
K6J80_RS17595	COG2211	Major facilitator Superfamily
K6J80_RS17605	COG3123	guanosine phosphorylase activity
K6J80_RS17610	COG1741	Belongs to the pirin family
K6J80_RS17620	COG5001	Diguanylate cyclase
K6J80_RS17625	COG0583	DNA-binding transcription factor activity
K6J80_RS17660	COG3706	GGDEF domain
K6J80_RS17665	COG1846	Transcriptional regulator
K6J80_RS17670	COG0835	chemotaxis
K6J80_RS17670	COG0784	Response regulator, receiver
K6J80_RS17675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6J80_RS17685	COG0393	Putative heavy-metal-binding
K6J80_RS17700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6J80_RS17705	COG3842	ATPase activity
K6J80_RS17715	COG1175	transmembrane transport
K6J80_RS17720	COG3833	ABC-type maltose transport systems, permease component
K6J80_RS17735	COG1349	DNA-binding transcription factor activity
K6J80_RS17740	COG2199	diguanylate cyclase activity
K6J80_RS17765	COG1278	Cold shock
K6J80_RS17770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6J80_RS17775	COG2354	Protein conserved in bacteria
K6J80_RS17780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6J80_RS17790	COG3152	Membrane
K6J80_RS17800	COG0418	dihydroorotase activity
K6J80_RS17805	COG3217	Mosc domain protein beta barrel domain protein
K6J80_RS17805	COG0633	Ferredoxin
K6J80_RS17805	COG3217	Mosc domain protein beta barrel domain protein
K6J80_RS17805	COG0633	Ferredoxin
K6J80_RS17840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K6J80_RS17845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6J80_RS17850	COG4558	Periplasmic binding protein
K6J80_RS17855	COG0848	biopolymer transport protein
K6J80_RS17860	COG0811	peptide transport
K6J80_RS17865	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K6J80_RS17875	COG3721	Heme iron utilization protein
K6J80_RS17880	COG0748	coenzyme F420 binding
K6J80_RS17890	COG3835	regulator
K6J80_RS17895	COG2610	gluconate transmembrane transporter activity
K6J80_RS17925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6J80_RS17930	COG0363	glucosamine-6-phosphate deaminase activity
K6J80_RS17935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6J80_RS17940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K6J80_RS17945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6J80_RS17965	COG0346	lactoylglutathione lyase activity
K6J80_RS17990	COG1063	alcohol dehydrogenase
K6J80_RS18035	COG0583	DNA-binding transcription factor activity
K6J80_RS18040	COG3048	D-serine ammonia-lyase activity
K6J80_RS18055	COG1294	oxidase, subunit
K6J80_RS18060	COG1271	oxidase subunit
K6J80_RS18065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6J80_RS18070	COG1686	Belongs to the peptidase S11 family
K6J80_RS18080	COG3047	cAMP biosynthetic process
K6J80_RS18090	COG3227	Zinc metalloprotease (Elastase)
K6J80_RS18100	COG2267	carboxylic ester hydrolase activity
K6J80_RS18105	COG2067	long-chain fatty acid transport protein
K6J80_RS18115	COG0366	Alpha amylase catalytic
K6J80_RS18120	COG4989	oxidoreductase activity
K6J80_RS18130	COG1136	(ABC) transporter
K6J80_RS18135	COG1136	(ABC) transporter
K6J80_RS18135	COG0577	efflux transmembrane transporter activity
K6J80_RS18150	COG3275	phosphorelay sensor kinase activity
K6J80_RS18155	COG3279	Response regulator of the LytR AlgR family
K6J80_RS18170	COG0531	amino acid
K6J80_RS18195	COG1765	OsmC-like protein
K6J80_RS18200	COG1253	flavin adenine dinucleotide binding
K6J80_RS18225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6J80_RS18240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6J80_RS18245	COG3186	Phenylalanine-4-hydroxylase
K6J80_RS18255	COG0456	acetyltransferase
K6J80_RS18260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6J80_RS18265	COG0662	Cupin 2, conserved barrel domain protein
K6J80_RS18270	COG0527	aspartate kinase activity
K6J80_RS18280	COG0459	protein refolding
K6J80_RS18285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K6J80_RS18290	COG2239	Acts as a magnesium transporter
K6J80_RS18300	COG1166	arginine decarboxylase activity
K6J80_RS18305	COG0010	Belongs to the arginase family
K6J80_RS18315	COG3227	Zinc metalloprotease (Elastase)
K6J80_RS18320	COG3397	chitin binding
K6J80_RS18325	COG3046	protein related to deoxyribodipyrimidine photolyase
K6J80_RS18335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6J80_RS18350	COG0513	Belongs to the DEAD box helicase family
K6J80_RS18360	COG1368	sulfuric ester hydrolase activity
K6J80_RS18365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6J80_RS18380	COG0546	phosphoglycolate phosphatase activity
K6J80_RS18420	COG0484	heat shock protein binding
K6J80_RS18430	COG5001	Diguanylate cyclase
K6J80_RS18430	COG1716	ATPase activity
K6J80_RS18445	COG4181	ATPase activity
K6J80_RS18450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K6J80_RS18465	COG1984	allophanate hydrolase subunit 2
K6J80_RS18475	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6J80_RS18480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6J80_RS18485	COG0840	transmembrane signaling receptor activity
K6J80_RS18490	COG0814	amino acid
K6J80_RS18495	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K6J80_RS18500	COG0513	Belongs to the DEAD box helicase family
K6J80_RS18505	COG1309	transcriptional regulator
K6J80_RS18515	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K6J80_RS18520	COG0494	nUDIX hydrolase
K6J80_RS18530	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K6J80_RS18540	COG1126	abc transporter atp-binding protein
K6J80_RS18545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6J80_RS18550	COG4215	(ABC) transporter
K6J80_RS18555	COG4160	amino acid transport
K6J80_RS18560	COG0583	DNA-binding transcription factor activity
K6J80_RS18590	COG3118	belongs to the thioredoxin family
K6J80_RS18595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6J80_RS18600	COG0247	lactate metabolic process
K6J80_RS18605	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
K6J80_RS18610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6J80_RS18615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6J80_RS18620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6J80_RS18630	COG2926	Belongs to the UPF0265 family
K6J80_RS18650	COG1879	ABC-type sugar transport system periplasmic component
K6J80_RS18655	COG5002	protein histidine kinase activity
K6J80_RS18655	COG0784	Response regulator, receiver
K6J80_RS18695	COG1492	cobalamin metabolic process
K6J80_RS18700	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6J80_RS18705	COG4149	molybdate abc transporter
K6J80_RS18710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K6J80_RS18740	COG1289	transmembrane transporter activity
K6J80_RS18745	COG0210	DNA helicase
K6J80_RS18760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6J80_RS18765	COG1335	isochorismatase
K6J80_RS18770	COG1803	Methylglyoxal synthase
K6J80_RS18775	COG1879	ABC-type sugar transport system periplasmic component
K6J80_RS18780	COG2198	Histidine kinase
K6J80_RS18780	COG2205	protein histidine kinase activity
K6J80_RS18780	COG0784	Response regulator, receiver
K6J80_RS18785	COG0469	pyruvate kinase activity
K6J80_RS18790	COG2271	Major facilitator Superfamily
K6J80_RS18800	COG4191	Histidine kinase
K6J80_RS18815	COG1979	alcohol dehydrogenase
K6J80_RS18825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6J80_RS18875	COG1476	TRANSCRIPTIONal
K6J80_RS18885	COG0840	transmembrane signaling receptor activity
K6J80_RS18930	COG0339	signal peptide processing
K6J80_RS19015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6J80_RS19065	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6J80_RS19135	COG2198	Histidine kinase
K6J80_RS19135	COG0643	Histidine kinase
K6J80_RS19165	COG2827	Endonuclease containing a URI domain