locus-tag	class	description
O3Y_RS00010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O3Y_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O3Y_RS00020	COG0706	membrane insertase activity
O3Y_RS00030	COG0594	ribonuclease P activity
O3Y_RS00035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O3Y_RS00040	COG1126	abc transporter atp-binding protein
O3Y_RS00055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O3Y_RS00060	COG0592	DNA-directed DNA polymerase activity
O3Y_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O3Y_RS00070	COG0187	DNA topoisomerase II activity
O3Y_RS00085	COG0071	Belongs to the small heat shock protein (HSP20) family
O3Y_RS00090	COG3977	Valine--pyruvate aminotransferase
O3Y_RS00095	COG0751	glycine-tRNA ligase activity
O3Y_RS00100	COG0752	glycyl-tRNA synthetase alpha subunit
O3Y_RS00105	COG2119	membrane
O3Y_RS00115	COG0425	Belongs to the sulfur carrier protein TusA family
O3Y_RS00125	COG0604	alcohol dehydrogenase
O3Y_RS00135	COG0129	dihydroxy-acid dehydratase activity
O3Y_RS00140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O3Y_RS00155	COG0606	chelatase, subunit chli
O3Y_RS00160	COG0204	Acyl-transferase
O3Y_RS00165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O3Y_RS00170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O3Y_RS00180	COG3084	Protein conserved in bacteria
O3Y_RS00190	COG4326	sporulation control protein
O3Y_RS00195	COG1272	protein, Hemolysin III
O3Y_RS00205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O3Y_RS00210	COG0569	domain protein
O3Y_RS00215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O3Y_RS00215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O3Y_RS00220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O3Y_RS00225	COG0242	peptide deformylase activity
O3Y_RS00230	COG1652	LysM domain
O3Y_RS00235	COG0758	DNA mediated transformation
O3Y_RS00240	COG2922	Belongs to the Smg family
O3Y_RS00245	COG0551	DNA topoisomerase type I activity
O3Y_RS00250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O3Y_RS00255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O3Y_RS00260	COG0009	L-threonylcarbamoyladenylate synthase
O3Y_RS00265	COG0408	coproporphyrinogen oxidase activity
O3Y_RS00270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O3Y_RS00280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O3Y_RS00320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O3Y_RS00325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O3Y_RS00335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O3Y_RS00340	COG2104	thiamine diphosphate biosynthetic process
O3Y_RS00345	COG2022	thiamine diphosphate biosynthetic process
O3Y_RS00350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O3Y_RS00355	COG0006	proline dipeptidase activity
O3Y_RS00355	COG0006	proline dipeptidase activity
O3Y_RS00375	COG1522	sequence-specific DNA binding
O3Y_RS00380	COG5002	protein histidine kinase activity
O3Y_RS00380	COG5001	Diguanylate cyclase
O3Y_RS00400	COG0589	response to stress
O3Y_RS00410	COG1528	Iron-storage protein
O3Y_RS00420	COG2081	HI0933 family
O3Y_RS00430	COG1322	Protein conserved in bacteria
O3Y_RS00435	COG2226	methyltransferase
O3Y_RS00450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O3Y_RS00455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O3Y_RS00460	COG0805	protein transport
O3Y_RS00465	COG1858	cytochrome C peroxidase
O3Y_RS00470	COG0534	Mate efflux family protein
O3Y_RS00480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O3Y_RS00490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O3Y_RS00495	COG3161	chorismate lyase activity
O3Y_RS00505	COG1580	Controls the rotational direction of flagella during chemotaxis
O3Y_RS00510	COG0840	transmembrane signaling receptor activity
O3Y_RS00520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O3Y_RS00530	COG0084	hydrolase, TatD family'
O3Y_RS00545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_RS00545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_RS00565	COG3078	GTPase activator activity
O3Y_RS00580	COG3071	HemY protein
O3Y_RS00585	COG2959	enzyme of heme biosynthesis
O3Y_RS00590	COG1587	Uroporphyrinogen-III synthase
O3Y_RS00595	COG0181	hydroxymethylbilane synthase activity
O3Y_RS00610	COG1965	Belongs to the frataxin family
O3Y_RS00620	COG0019	diaminopimelate decarboxylase activity
O3Y_RS00625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O3Y_RS00635	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O3Y_RS00640	COG1011	Hydrolase
O3Y_RS00645	COG2199	diguanylate cyclase activity
O3Y_RS00645	COG3287	FIST C domain
O3Y_RS00645	COG2200	EAL domain
O3Y_RS00665	COG0561	phosphatase activity
O3Y_RS00670	COG2267	carboxylic ester hydrolase activity
O3Y_RS00675	COG1280	lysine exporter protein (LysE YggA)
O3Y_RS00680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O3Y_RS00685	COG0783	Belongs to the Dps family
O3Y_RS00720	COG0742	ribosomal rna small subunit methyltransferase
O3Y_RS00725	COG0552	protein localization to endoplasmic reticulum
O3Y_RS00730	COG2884	Cell division ATP-binding protein ftsE
O3Y_RS00735	COG2177	Part of the ABC transporter FtsEX involved in
O3Y_RS00740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O3Y_RS00745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_RS00760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O3Y_RS00765	COG4206	TonB-dependent receptor
O3Y_RS00770	COG1404	Belongs to the peptidase S8 family
O3Y_RS00775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O3Y_RS00810	COG0583	DNA-binding transcription factor activity
O3Y_RS00815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O3Y_RS00820	COG2960	long-chain fatty acid transporting porin activity
O3Y_RS00825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O3Y_RS00830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_RS00835	COG1309	transcriptional regulator
O3Y_RS00890	COG0747	negative chemotaxis
O3Y_RS00895	COG0601	transmembrane transport
O3Y_RS00900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3Y_RS00910	COG2131	deaminase
O3Y_RS00935	COG3621	Patatin-like phospholipase
O3Y_RS00975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_RS00980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O3Y_RS00990	COG0210	DNA helicase
O3Y_RS00995	COG1280	lysine exporter protein (LysE YggA)
O3Y_RS01010	COG2962	Rard protein
O3Y_RS01015	COG0514	ATP-dependent DNA helicase (RecQ)
O3Y_RS01030	COG1132	(ABC) transporter
O3Y_RS01035	COG4774	siderophore transport
O3Y_RS01040	COG1120	ATPase activity
O3Y_RS01065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O3Y_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_RS01070	COG1263	PTS System
O3Y_RS01075	COG2862	Uncharacterized protein family, UPF0114
O3Y_RS01080	COG1561	YicC-like family, N-terminal region
O3Y_RS01085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O3Y_RS01090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O3Y_RS01095	COG1560	Kdo2-lipid A biosynthetic process
O3Y_RS01100	COG1560	Kdo2-lipid A biosynthetic process
O3Y_RS01105	COG1309	transcriptional regulator
O3Y_RS01110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O3Y_RS01120	COG2003	Belongs to the UPF0758 family
O3Y_RS01125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O3Y_RS01130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O3Y_RS01140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O3Y_RS01145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O3Y_RS01150	COG0859	PFAM glycosyl transferase family 9
O3Y_RS01155	COG0463	Glycosyl transferase, family 2
O3Y_RS01160	COG0859	PFAM glycosyl transferase family 9
O3Y_RS01165	COG3642	lipopolysaccharide core region biosynthetic process
O3Y_RS01195	COG1519	Transferase
O3Y_RS01230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O3Y_RS01235	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
O3Y_RS01235	COG0662	Cupin 2, conserved barrel domain protein
O3Y_RS01240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O3Y_RS01245	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
O3Y_RS01275	COG0318	PFAM AMP-dependent synthetase and ligase
O3Y_RS01280	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS01280	COG1454	alcohol dehydrogenase
O3Y_RS01295	COG5433	transposase activity
O3Y_RS01340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O3Y_RS01345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
O3Y_RS01350	COG0668	transmembrane transport
O3Y_RS01355	COG1573	uracil-dna glycosylase
O3Y_RS01365	COG3068	Protein conserved in bacteria
O3Y_RS01375	COG1940	carbohydrate kinase activity
O3Y_RS01380	COG1253	flavin adenine dinucleotide binding
O3Y_RS01390	COG0776	regulation of translation
O3Y_RS01400	COG0151	Belongs to the GarS family
O3Y_RS01410	COG0789	Transcriptional regulator
O3Y_RS01415	COG3710	Transcriptional regulator
O3Y_RS01420	COG0531	amino acid
O3Y_RS01425	COG1982	Orn Lys Arg decarboxylase major
O3Y_RS01430	COG0840	transmembrane signaling receptor activity
O3Y_RS01450	COG0800	Aldolase
O3Y_RS01460	COG3265	gluconokinase activity
O3Y_RS01465	COG0129	dihydroxy-acid dehydratase activity
O3Y_RS01470	COG1609	Transcriptional regulator
O3Y_RS01475	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
O3Y_RS01480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O3Y_RS01485	COG2264	protein methyltransferase activity
O3Y_RS01490	COG0439	Biotin carboxylase
O3Y_RS01495	COG0511	ligase activity, forming carbon-carbon bonds
O3Y_RS01500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O3Y_RS01505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O3Y_RS01525	COG2814	Major facilitator Superfamily
O3Y_RS01530	COG0784	Response regulator, receiver
O3Y_RS01530	COG2205	protein histidine kinase activity
O3Y_RS01535	COG0248	Ppx GppA phosphatase
O3Y_RS01540	COG0513	Belongs to the DEAD box helicase family
O3Y_RS01545	COG3118	belongs to the thioredoxin family
O3Y_RS01560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O3Y_RS01605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O3Y_RS01620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O3Y_RS01630	COG1072	(Pantothenic acid kinase))
O3Y_RS01655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O3Y_RS01660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O3Y_RS01665	COG0250	Participates in transcription elongation, termination and antitermination
O3Y_RS01670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O3Y_RS01680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O3Y_RS01685	COG0222	ribosome binding
O3Y_RS01690	COG0085	RNA polymerase activity
O3Y_RS01695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O3Y_RS01700	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
O3Y_RS01705	COG2816	NAD+ diphosphatase activity
O3Y_RS01710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O3Y_RS01725	COG4942	peptidase
O3Y_RS01730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O3Y_RS01740	COG0471	metal ion transport
O3Y_RS01745	COG0688	phosphatidylethanolamine metabolic process
O3Y_RS01750	COG1162	GTPase activity
O3Y_RS01755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O3Y_RS01800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O3Y_RS01805	COG0802	atpase or kinase
O3Y_RS01815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O3Y_RS01820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O3Y_RS01825	COG1923	regulation of RNA biosynthetic process
O3Y_RS01830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O3Y_RS01835	COG0330	HflC and HflK could
O3Y_RS01840	COG0330	HflC and HflK could
O3Y_RS01845	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
O3Y_RS01850	COG2900	Belongs to the SlyX family
O3Y_RS01860	COG0545	Peptidyl-prolyl cis-trans isomerase
O3Y_RS01865	COG2964	Protein conserved in bacteria
O3Y_RS01870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
O3Y_RS01875	COG2923	Belongs to the DsrF TusC family
O3Y_RS01890	COG0049	tRNA binding
O3Y_RS01895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O3Y_RS01900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O3Y_RS01905	COG2906	2 iron, 2 sulfur cluster binding
O3Y_RS01915	COG0360	Binds together with S18 to 16S ribosomal RNA
O3Y_RS01920	COG2965	DNA replication, synthesis of RNA primer
O3Y_RS01925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O3Y_RS01930	COG0359	binds to the 23S rRNA
O3Y_RS01945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O3Y_RS01950	COG0432	Pfam Uncharacterised protein family UPF0047
O3Y_RS01970	COG0735	belongs to the Fur family
O3Y_RS01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O3Y_RS02000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O3Y_RS02010	COG0175	sulfate reduction
O3Y_RS02050	COG1410	methionine synthase
O3Y_RS02050	COG0646	methionine synthase
O3Y_RS02055	COG0527	aspartate kinase activity
O3Y_RS02060	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O3Y_RS02070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O3Y_RS02085	COG0629	single-stranded DNA binding
O3Y_RS02090	COG2199	diguanylate cyclase activity
O3Y_RS02090	COG2200	EAL domain
O3Y_RS02115	COG3267	Type II secretory pathway component ExeA
O3Y_RS02115	COG3409	Peptidoglycan-binding domain 1 protein
O3Y_RS02125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_RS02130	COG1459	type II secretion system
O3Y_RS02140	COG2165	general secretion pathway protein
O3Y_RS02145	COG2165	general secretion pathway protein
O3Y_RS02175	COG1077	Cell shape determining protein MreB Mrl
O3Y_RS02180	COG1792	Involved in formation and maintenance of cell shape
O3Y_RS02185	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O3Y_RS02190	COG0424	maF-like protein
O3Y_RS02200	COG3164	Protein of unknown function
O3Y_RS02205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O3Y_RS02210	COG0312	modulator of DNA gyrase
O3Y_RS02215	COG2235	arginine
O3Y_RS02235	COG0589	response to stress
O3Y_RS02245	COG2358	TRAP transporter, solute receptor (TAXI family
O3Y_RS02250	COG1438	arginine binding
O3Y_RS02255	COG0039	L-malate dehydrogenase activity
O3Y_RS02260	COG0531	amino acid
O3Y_RS02265	COG0142	geranyltranstransferase activity
O3Y_RS02270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O3Y_RS02275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O3Y_RS02280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O3Y_RS02285	COG2966	Psort location CytoplasmicMembrane, score
O3Y_RS02290	COG3610	response to peptide
O3Y_RS02300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O3Y_RS02305	COG2967	ApaG domain
O3Y_RS02310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O3Y_RS02315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O3Y_RS02320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O3Y_RS02325	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
O3Y_RS02330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O3Y_RS02360	COG0840	transmembrane signaling receptor activity
O3Y_RS02385	COG0741	lytic transglycosylase activity
O3Y_RS02390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
O3Y_RS02395	COG1194	a g-specific adenine glycosylase
O3Y_RS02405	COG2066	Belongs to the glutaminase family
O3Y_RS02410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O3Y_RS02415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O3Y_RS02425	COG1872	DUF167
O3Y_RS02430	COG0762	integral membrane protein
O3Y_RS02435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O3Y_RS02440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O3Y_RS02460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O3Y_RS02465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O3Y_RS02470	COG1678	Uncharacterized ACR, COG1678
O3Y_RS02475	COG0189	ligase activity
O3Y_RS02480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O3Y_RS02485	COG2356	endonuclease I
O3Y_RS02495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O3Y_RS02505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O3Y_RS02510	COG0583	DNA-binding transcription factor activity
O3Y_RS02515	COG4771	TonB-dependent receptor
O3Y_RS02520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O3Y_RS02525	COG0126	phosphoglycerate kinase activity
O3Y_RS02530	COG0191	fructose-bisphosphate aldolase activity
O3Y_RS02540	COG0668	transmembrane transport
O3Y_RS02545	COG1279	arginine transmembrane transporter activity
O3Y_RS02565	COG1349	DNA-binding transcription factor activity
O3Y_RS02570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O3Y_RS02575	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
O3Y_RS02630	COG0328	RNA-DNA hybrid ribonuclease activity
O3Y_RS02650	COG4969	Belongs to the N-Me-Phe pilin family
O3Y_RS02655	COG0739	heme binding
O3Y_RS02690	COG2003	Belongs to the UPF0758 family
O3Y_RS02720	COG0582	viral genome integration into host DNA
O3Y_RS02735	COG0358	DNA primase activity
O3Y_RS02740	COG1610	YqeY-like protein
O3Y_RS02745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O3Y_RS02750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O3Y_RS02760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O3Y_RS02765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O3Y_RS02770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O3Y_RS02775	COG1968	undecaprenyl-diphosphatase activity
O3Y_RS02780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O3Y_RS02785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O3Y_RS02790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O3Y_RS02795	COG0585	pseudouridine synthase activity
O3Y_RS02800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O3Y_RS02805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O3Y_RS02815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O3Y_RS02820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O3Y_RS02840	COG4208	sulfate ABC transporter
O3Y_RS02845	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O3Y_RS02855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O3Y_RS02865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O3Y_RS02870	COG0527	aspartate kinase activity
O3Y_RS02875	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O3Y_RS02925	COG3630	sodium ion export across plasma membrane
O3Y_RS02930	COG0511	ligase activity, forming carbon-carbon bonds
O3Y_RS02930	COG5016	pyruvate
O3Y_RS02935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
O3Y_RS02945	COG1238	metal cluster binding
O3Y_RS02950	COG0612	Peptidase, M16
O3Y_RS02955	COG2918	glutathione biosynthetic process
O3Y_RS02960	COG1854	S-ribosylhomocysteine lyase activity
O3Y_RS02965	COG4536	flavin adenine dinucleotide binding
O3Y_RS02970	COG4137	Cytochrome C assembly protein
O3Y_RS02975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O3Y_RS02980	COG0228	four-way junction DNA binding
O3Y_RS02985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O3Y_RS02990	COG0336	Belongs to the RNA methyltransferase TrmD family
O3Y_RS02995	COG0335	large ribosomal subunit rRNA binding
O3Y_RS03000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O3Y_RS03005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O3Y_RS03015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O3Y_RS03025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O3Y_RS03030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O3Y_RS03035	COG0723	plastoquinol--plastocyanin reductase activity
O3Y_RS03040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O3Y_RS03045	COG2857	Cytochrome c1
O3Y_RS03050	COG0625	glutathione transferase activity
O3Y_RS03055	COG2969	positive regulation of protein catabolic process
O3Y_RS03060	COG2823	Periplasmic or secreted lipoprotein
O3Y_RS03065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O3Y_RS03070	COG0792	nuclease activity
O3Y_RS03075	COG3107	peptidoglycan biosynthetic process
O3Y_RS03080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O3Y_RS03085	COG1131	(ABC) transporter
O3Y_RS03090	COG0842	Transport permease protein
O3Y_RS03095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O3Y_RS03100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O3Y_RS03105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O3Y_RS03115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O3Y_RS03125	COG1489	DNA binding
O3Y_RS03135	COG1643	Atp-dependent helicase
O3Y_RS03140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O3Y_RS03145	COG1752	Esterase of the alpha-beta hydrolase superfamily
O3Y_RS03150	COG1049	propionate catabolic process, 2-methylcitrate cycle
O3Y_RS03155	COG3112	Uncharacterised protein family (UPF0231)
O3Y_RS03160	COG0347	Belongs to the P(II) protein family
O3Y_RS03165	COG0004	ammonium transporteR
O3Y_RS03170	COG1840	ABC-type Fe3 transport system, periplasmic component
O3Y_RS03180	COG3842	ATPase activity
O3Y_RS03200	COG2971	BadF BadG BcrA BcrD
O3Y_RS03210	COG4608	Belongs to the ABC transporter superfamily
O3Y_RS03215	COG0444	Belongs to the ABC transporter superfamily
O3Y_RS03220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3Y_RS03225	COG0601	transmembrane transport
O3Y_RS03230	COG0747	negative chemotaxis
O3Y_RS03240	COG0784	Response regulator, receiver
O3Y_RS03240	COG2205	protein histidine kinase activity
O3Y_RS03245	COG2813	Specifically methylates the guanine in position
O3Y_RS03250	COG0628	permease
O3Y_RS03260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O3Y_RS03270	COG0316	Belongs to the HesB IscA family
O3Y_RS03285	COG0739	heme binding
O3Y_RS03290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O3Y_RS03295	COG2027	D-alanyl-D-alanine carboxypeptidase
O3Y_RS03300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O3Y_RS03305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O3Y_RS03310	COG1534	Rna-binding protein
O3Y_RS03315	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O3Y_RS03320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O3Y_RS03325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O3Y_RS03335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O3Y_RS03350	COG0779	Required for maturation of 30S ribosomal subunits
O3Y_RS03355	COG0195	Participates in both transcription termination and antitermination
O3Y_RS03360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O3Y_RS03365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O3Y_RS03375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O3Y_RS03400	COG0826	peptidase U32
O3Y_RS03405	COG0826	peptidase U32
O3Y_RS03415	COG3154	lipid carrier protein
O3Y_RS03420	COG3153	acetyltransferase
O3Y_RS03445	COG0513	Belongs to the DEAD box helicase family
O3Y_RS03460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
O3Y_RS03465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O3Y_RS03470	COG2204	response regulator
O3Y_RS03480	COG0667	Aldo Keto reductase
O3Y_RS03495	COG0494	nUDIX hydrolase
O3Y_RS03500	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
O3Y_RS03505	COG0730	response to heat
O3Y_RS03510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O3Y_RS03520	COG1283	sodium-dependent phosphate transmembrane transporter activity
O3Y_RS03525	COG0583	DNA-binding transcription factor activity
O3Y_RS03530	COG0640	Transcriptional regulator
O3Y_RS03535	COG0268	Binds directly to 16S ribosomal RNA
O3Y_RS03540	COG0728	peptidoglycan biosynthetic process
O3Y_RS03545	COG0196	riboflavin kinase activity
O3Y_RS03560	COG1047	Peptidyl-prolyl cis-trans
O3Y_RS03565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O3Y_RS03570	COG1966	Carbon starvation protein
O3Y_RS03585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O3Y_RS03590	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O3Y_RS03600	COG3279	Response regulator of the LytR AlgR family
O3Y_RS03605	COG3275	phosphorelay sensor kinase activity
O3Y_RS03610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O3Y_RS03615	COG1605	Chorismate mutase
O3Y_RS03615	COG0287	Prephenate dehydrogenase
O3Y_RS03625	COG0488	(ABC) transporter
O3Y_RS03635	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
O3Y_RS03645	COG5001	Diguanylate cyclase
O3Y_RS03650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O3Y_RS03655	COG1605	Chorismate mutase
O3Y_RS03655	COG0077	Prephenate dehydratase
O3Y_RS03660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O3Y_RS03665	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3Y_RS03670	COG0564	pseudouridine synthase activity
O3Y_RS03680	COG0542	response to heat
O3Y_RS03720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O3Y_RS03725	COG0826	peptidase U32
O3Y_RS03735	COG0745	RESPONSE REGULATOR receiver
O3Y_RS03740	COG5002	protein histidine kinase activity
O3Y_RS03750	COG0248	Ppx GppA phosphatase
O3Y_RS03765	COG0581	inorganic phosphate transmembrane transporter activity
O3Y_RS03770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O3Y_RS03785	COG3142	Participates in the control of copper homeostasis
O3Y_RS03790	COG0450	alkyl hydroperoxide reductase
O3Y_RS03795	COG0583	DNA-binding transcription factor activity
O3Y_RS03800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O3Y_RS03810	COG0517	IMP dehydrogenase activity
O3Y_RS03830	COG1862	Preprotein translocase
O3Y_RS03835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O3Y_RS03840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O3Y_RS03845	COG0483	inositol monophosphate 1-phosphatase activity
O3Y_RS03855	COG1959	2 iron, 2 sulfur cluster binding
O3Y_RS03860	COG1104	cysteine desulfurase activity
O3Y_RS03865	COG0822	iron-sulfur transferase activity
O3Y_RS03875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O3Y_RS03880	COG0443	Heat shock 70 kDa protein
O3Y_RS03885	COG0633	Ferredoxin
O3Y_RS03890	COG2975	iron-sulfur cluster assembly
O3Y_RS03895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O3Y_RS03900	COG0105	UTP biosynthetic process
O3Y_RS03905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O3Y_RS03915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O3Y_RS03920	COG0124	histidyl-tRNA synthetase
O3Y_RS03925	COG2976	Protein conserved in bacteria
O3Y_RS03930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3Y_RS03935	COG1160	GTP binding
O3Y_RS03950	COG1570	exodeoxyribonuclease VII activity
O3Y_RS03955	COG0517	IMP dehydrogenase activity
O3Y_RS03955	COG0516	GMP reductase activity
O3Y_RS03960	COG0519	Catalyzes the synthesis of GMP from XMP
O3Y_RS03960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O3Y_RS03970	COG1584	GPR1 FUN34 yaaH family protein
O3Y_RS03975	COG3433	isochorismatase activity
O3Y_RS03975	COG1535	isochorismatase
O3Y_RS03980	COG1021	2,3-dihydroxybenzoate-AMP ligase
O3Y_RS03985	COG1169	isochorismate synthase
O3Y_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
O3Y_RS04000	COG4592	Periplasmic binding protein
O3Y_RS04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3Y_RS04010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O3Y_RS04015	COG1120	ATPase activity
O3Y_RS04025	COG0583	DNA-binding transcription factor activity
O3Y_RS04030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
O3Y_RS04035	COG1115	amino acid carrier protein
O3Y_RS04045	COG0583	DNA-binding transcription factor activity
O3Y_RS04060	COG4565	transcriptional regulatory protein
O3Y_RS04070	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
O3Y_RS04075	COG0511	ligase activity, forming carbon-carbon bonds
O3Y_RS04075	COG5016	pyruvate
O3Y_RS04080	COG3630	sodium ion export across plasma membrane
O3Y_RS04090	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
O3Y_RS04100	COG2301	Belongs to the HpcH HpaI aldolase family
O3Y_RS04105	COG3051	citrate lyase alpha subunit
O3Y_RS04125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O3Y_RS04130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O3Y_RS04135	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
O3Y_RS04205	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS04225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O3Y_RS04230	COG0840	transmembrane signaling receptor activity
O3Y_RS04235	COG3710	Transcriptional regulator
O3Y_RS04245	COG2165	general secretion pathway protein
O3Y_RS04260	COG4796	Type ii and iii secretion system protein
O3Y_RS04280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_RS04285	COG1459	type II secretion system
O3Y_RS04295	COG2207	Transcriptional regulator
O3Y_RS04300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O3Y_RS04320	COG0739	heme binding
O3Y_RS04330	COG3064	Membrane
O3Y_RS04340	COG0582	viral genome integration into host DNA
O3Y_RS04345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O3Y_RS04350	COG2867	negative regulation of translational initiation
O3Y_RS04355	COG2914	Belongs to the UPF0125 (RnfH) family
O3Y_RS04360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O3Y_RS04365	COG0497	DNA recombination
O3Y_RS04370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O3Y_RS04375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O3Y_RS04380	COG0443	Heat shock 70 kDa protein
O3Y_RS04385	COG0484	heat shock protein binding
O3Y_RS04420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O3Y_RS04435	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O3Y_RS04445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O3Y_RS04445	COG0047	phosphoribosylformylglycinamidine synthase activity
O3Y_RS04475	COG0442	prolyl-tRNA aminoacylation
O3Y_RS04480	COG1720	tRNA m6t6A37 methyltransferase activity
O3Y_RS04485	COG0254	rRNA binding
O3Y_RS04490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O3Y_RS04495	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O3Y_RS04500	COG1671	Belongs to the UPF0178 family
O3Y_RS04510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_RS04525	COG3098	single-species biofilm formation
O3Y_RS04530	COG0564	pseudouridine synthase activity
O3Y_RS04535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O3Y_RS04540	COG0142	geranyltranstransferase activity
O3Y_RS04545	COG1722	exodeoxyribonuclease VII activity
O3Y_RS04550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O3Y_RS04560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O3Y_RS04560	COG0301	tRNA thio-modification
O3Y_RS04570	COG0583	DNA-binding transcription factor activity
O3Y_RS04575	COG2363	Small membrane protein
O3Y_RS04580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_RS04585	COG1611	Belongs to the LOG family
O3Y_RS04600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O3Y_RS04600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O3Y_RS04610	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
O3Y_RS04615	COG1464	Belongs to the NlpA lipoprotein family
O3Y_RS04620	COG2011	ABC-type metal ion transport system permease component
O3Y_RS04625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O3Y_RS04630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O3Y_RS04635	COG1609	Transcriptional regulator
O3Y_RS04640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_RS04640	COG1263	PTS System
O3Y_RS04645	COG0366	Alpha amylase catalytic
O3Y_RS04675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O3Y_RS04680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O3Y_RS04685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O3Y_RS04690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O3Y_RS04695	COG0110	maltose O-acetyltransferase activity
O3Y_RS04715	COG1045	serine acetyltransferase
O3Y_RS04725	COG0438	transferase activity, transferring glycosyl groups
O3Y_RS04735	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O3Y_RS04765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O3Y_RS04775	COG1596	polysaccharide export
O3Y_RS04800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O3Y_RS04810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O3Y_RS04815	COG0321	lipoyl(octanoyl) transferase activity
O3Y_RS04820	COG2921	Belongs to the UPF0250 family
O3Y_RS04830	COG1686	Belongs to the peptidase S11 family
O3Y_RS04835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O3Y_RS04840	COG0772	Belongs to the SEDS family
O3Y_RS04845	COG0768	penicillin binding
O3Y_RS04850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O3Y_RS04855	COG0799	negative regulation of ribosome biogenesis
O3Y_RS04860	COG1466	dna polymerase III delta subunit
O3Y_RS04865	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
O3Y_RS04870	COG0495	leucyl-tRNA aminoacylation
O3Y_RS04875	COG2888	peptidyl-tyrosine sulfation
O3Y_RS04880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O3Y_RS04885	COG4535	Mg2 and Co2 transporter CorC
O3Y_RS04895	COG1702	phosphate starvation-inducible protein PhoH
O3Y_RS04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O3Y_RS04905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_RS04910	COG2190	(PTS) system
O3Y_RS04920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_RS04930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O3Y_RS04935	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
O3Y_RS04940	COG3115	cell septum assembly
O3Y_RS04945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O3Y_RS04960	COG0789	Transcriptional regulator
O3Y_RS04965	COG1585	Membrane protein implicated in regulation of membrane protease activity
O3Y_RS04970	COG0330	HflC and HflK could
O3Y_RS04975	COG3118	belongs to the thioredoxin family
O3Y_RS04980	COG0300	oxidoreductase activity
O3Y_RS04985	COG1090	epimerase
O3Y_RS04990	COG0622	Phosphoesterase
O3Y_RS05005	COG3710	Transcriptional regulator
O3Y_RS05010	COG0326	Molecular chaperone. Has ATPase activity
O3Y_RS05015	COG0563	adenylate kinase activity
O3Y_RS05020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O3Y_RS05035	COG0367	asparagine synthase
O3Y_RS05040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O3Y_RS05040	COG4651	solute:proton antiporter activity
O3Y_RS05045	COG1940	carbohydrate kinase activity
O3Y_RS05045	COG1846	Transcriptional regulator
O3Y_RS05050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O3Y_RS05055	COG2190	(PTS) system
O3Y_RS05055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_RS05055	COG1263	PTS System
O3Y_RS05070	COG0101	tRNA pseudouridine synthase activity
O3Y_RS05075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O3Y_RS05080	COG0285	dihydrofolate synthase activity
O3Y_RS05085	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
O3Y_RS05090	COG1286	toxin biosynthetic process
O3Y_RS05095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O3Y_RS05100	COG2056	Na+-H+ antiporter family
O3Y_RS05105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O3Y_RS05125	COG0346	lactoylglutathione lyase activity
O3Y_RS05130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O3Y_RS05150	COG4656	Part of a membrane complex involved in electron transport
O3Y_RS05155	COG2878	Part of a membrane complex involved in electron transport
O3Y_RS05160	COG4657	Part of a membrane complex involved in electron transport
O3Y_RS05170	COG0556	nucleotide-excision repair
O3Y_RS05180	COG2204	response regulator
O3Y_RS05185	COG2198	Histidine kinase
O3Y_RS05190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O3Y_RS05195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O3Y_RS05200	COG0521	Mo-molybdopterin cofactor biosynthetic process
O3Y_RS05205	COG0315	cyclic pyranopterin monophosphate synthase activity
O3Y_RS05210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O3Y_RS05215	COG0314	molybdopterin synthase activity
O3Y_RS05220	COG2199	diguanylate cyclase activity
O3Y_RS05225	COG0517	IMP dehydrogenase activity
O3Y_RS05225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O3Y_RS05225	COG0617	tRNA 3'-terminal CCA addition
O3Y_RS05240	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
O3Y_RS05250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_RS05250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_RS05255	COG0489	protein tyrosine kinase activity
O3Y_RS05265	COG0572	uridine kinase
O3Y_RS05270	COG2982	Protein involved in outer membrane biogenesis
O3Y_RS05275	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
O3Y_RS05280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O3Y_RS05290	COG2067	long-chain fatty acid transport protein
O3Y_RS05305	COG0183	Belongs to the thiolase family
O3Y_RS05310	COG1250	3-hydroxyacyl-CoA dehydrogenase
O3Y_RS05310	COG1024	Enoyl-CoA hydratase
O3Y_RS05315	COG0778	Nitroreductase
O3Y_RS05320	COG0583	DNA-binding transcription factor activity
O3Y_RS05325	COG0745	RESPONSE REGULATOR receiver
O3Y_RS05335	COG2832	Protein of unknown function (DUF454)
O3Y_RS05340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O3Y_RS05350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O3Y_RS05355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O3Y_RS05365	COG2983	Belongs to the UPF0260 family
O3Y_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
O3Y_RS05375	COG0616	signal peptide processing
O3Y_RS05385	COG1522	sequence-specific DNA binding
O3Y_RS05390	COG1946	Acyl-CoA thioesterase
O3Y_RS05410	COG3706	GGDEF domain
O3Y_RS05415	COG0640	Transcriptional regulator
O3Y_RS05420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O3Y_RS05445	COG1881	PFAM PEBP family protein
O3Y_RS05465	COG0009	L-threonylcarbamoyladenylate synthase
O3Y_RS05480	COG2201	protein-glutamate methylesterase activity
O3Y_RS05490	COG5002	protein histidine kinase activity
O3Y_RS05495	COG4191	Histidine kinase
O3Y_RS05500	COG5001	Diguanylate cyclase
O3Y_RS05500	COG3300	MHYT domain
O3Y_RS05505	COG2204	response regulator
O3Y_RS05525	COG0601	transmembrane transport
O3Y_RS05530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O3Y_RS05535	COG0444	Belongs to the ABC transporter superfamily
O3Y_RS05540	COG4608	Belongs to the ABC transporter superfamily
O3Y_RS05545	COG0435	Glutathione S-transferase
O3Y_RS05550	COG0280	phosphate acetyltransferase
O3Y_RS05550	COG0857	belongs to the CobB CobQ family
O3Y_RS05555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O3Y_RS05560	COG3092	negative regulation of chromosome organization
O3Y_RS05565	COG4628	conserved protein (DUF2132)
O3Y_RS05575	COG4120	Belongs to the binding-protein-dependent transport system permease family
O3Y_RS05585	COG2203	Gaf domain
O3Y_RS05585	COG2199	diguanylate cyclase activity
O3Y_RS05590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O3Y_RS05600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O3Y_RS05605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O3Y_RS05610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O3Y_RS05615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O3Y_RS05620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O3Y_RS05625	COG0156	8-amino-7-oxononanoate synthase activity
O3Y_RS05630	COG2226	methyltransferase
O3Y_RS05635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O3Y_RS05645	COG0501	Belongs to the peptidase M48B family
O3Y_RS05655	COG0300	oxidoreductase activity
O3Y_RS05670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O3Y_RS05680	COG2268	Band 7 protein
O3Y_RS05690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O3Y_RS05695	COG2915	High frequency lysogenization protein hflD homolog
O3Y_RS05700	COG0482	sulfurtransferase activity
O3Y_RS05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O3Y_RS05710	COG2916	Histone family protein nucleoid-structuring protein H-NS
O3Y_RS05715	COG1757	Na H antiporter
O3Y_RS05720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O3Y_RS05725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O3Y_RS05730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O3Y_RS05735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O3Y_RS05735	COG0131	Imidazoleglycerol-phosphate dehydratase
O3Y_RS05740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O3Y_RS05745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O3Y_RS05750	COG0107	imidazoleglycerol-phosphate synthase activity
O3Y_RS05755	COG0140	phosphoribosyl-ATP diphosphatase activity
O3Y_RS05755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O3Y_RS05760	COG1187	pseudouridine synthase activity
O3Y_RS05770	COG1278	Cold shock
O3Y_RS05775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O3Y_RS05780	COG0542	response to heat
O3Y_RS05785	COG3273	potassium ion transport
O3Y_RS05785	COG2985	domain, Protein
O3Y_RS05790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O3Y_RS05795	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS05795	COG1454	alcohol dehydrogenase
O3Y_RS05800	COG1737	Transcriptional regulator
O3Y_RS05805	COG0076	glutamate decarboxylase activity
O3Y_RS05815	COG2431	L-lysine efflux transmembrane transporter activity
O3Y_RS05825	COG3070	regulator of competence-specific genes
O3Y_RS05840	COG3852	Histidine kinase
O3Y_RS05850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O3Y_RS05865	COG0189	ligase activity
O3Y_RS05865	COG4067	protein conserved in archaea
O3Y_RS05870	COG0500	methyltransferase
O3Y_RS05875	COG4106	trans-aconitate 2-methyltransferase activity
O3Y_RS05880	COG1801	Protein of unknown function DUF72
O3Y_RS05885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O3Y_RS05890	COG1435	thymidine kinase activity
O3Y_RS05900	COG0159	tryptophan synthase activity
O3Y_RS05905	COG0133	tryptophan synthase activity
O3Y_RS05910	COG0134	indole-3-glycerol-phosphate synthase activity
O3Y_RS05910	COG0135	phosphoribosylanthranilate isomerase activity
O3Y_RS05915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O3Y_RS05920	COG0512	Glutamine amidotransferase of anthranilate synthase
O3Y_RS05925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O3Y_RS05935	COG0613	PHP domain protein
O3Y_RS05940	COG0009	L-threonylcarbamoyladenylate synthase
O3Y_RS05945	COG1187	pseudouridine synthase activity
O3Y_RS05950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O3Y_RS05955	COG4988	ABC transporter
O3Y_RS05960	COG0492	ferredoxin-NADP+ reductase activity
O3Y_RS05970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O3Y_RS05975	COG3706	GGDEF domain
O3Y_RS05980	COG2949	membrane
O3Y_RS05990	COG0281	malic enzyme
O3Y_RS06000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O3Y_RS06020	COG2885	chlorophyll binding
O3Y_RS06035	COG0247	lactate metabolic process
O3Y_RS06035	COG0277	FAD linked oxidase domain protein
O3Y_RS06055	COG2986	histidine ammonia-lyase
O3Y_RS06060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O3Y_RS06065	COG0010	Belongs to the arginase family
O3Y_RS06070	COG1228	amidohydrolase
O3Y_RS06085	COG3099	Belongs to the UPF0263 family
O3Y_RS06090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O3Y_RS06100	COG5001	Diguanylate cyclase
O3Y_RS06105	COG0417	DNA replication proofreading
O3Y_RS06110	COG2197	response regulator
O3Y_RS06115	COG0322	excinuclease ABC activity
O3Y_RS06155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O3Y_RS06160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_RS06160	COG0072	phenylalanine-tRNA ligase activity
O3Y_RS06165	COG0776	regulation of translation
O3Y_RS06205	COG1346	cytolysis
O3Y_RS06210	COG1380	Effector of murein hydrolase LrgA
O3Y_RS06215	COG2925	Exonuclease
O3Y_RS06220	COG1823	symporter activity
O3Y_RS06225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_RS06230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O3Y_RS06235	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
O3Y_RS06255	COG4139	cobalamin transport
O3Y_RS06305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O3Y_RS06310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O3Y_RS06315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O3Y_RS06325	COG1054	Belongs to the UPF0176 family
O3Y_RS06335	COG2814	Major facilitator Superfamily
O3Y_RS06345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O3Y_RS06370	COG2989	Protein conserved in bacteria
O3Y_RS06375	COG3108	Peptidase M15
O3Y_RS06380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3Y_RS06395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
O3Y_RS06420	COG1846	Transcriptional regulator
O3Y_RS06425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O3Y_RS06430	COG0726	polysaccharide deacetylase
O3Y_RS06435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O3Y_RS06445	COG1447	Phosphotransferase system cellobiose-specific component IIA
O3Y_RS06450	COG1486	melibiose metabolic process
O3Y_RS06460	COG1609	Transcriptional regulator
O3Y_RS06465	COG2943	transferase activity, transferring hexosyl groups
O3Y_RS06470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
O3Y_RS06475	COG0840	transmembrane signaling receptor activity
O3Y_RS06490	COG1448	Aminotransferase
O3Y_RS06500	COG3437	response regulator, receiver
O3Y_RS06500	COG2770	Histidine kinase
O3Y_RS06505	COG3437	response regulator, receiver
O3Y_RS06505	COG2770	Histidine kinase
O3Y_RS06510	COG0351	phosphomethylpyrimidine kinase
O3Y_RS06515	COG0017	Asparaginyl-tRNA synthetase
O3Y_RS06520	COG0840	transmembrane signaling receptor activity
O3Y_RS06525	COG0720	synthase
O3Y_RS06530	COG1760	l-serine dehydratase
O3Y_RS06535	COG0814	amino acid
O3Y_RS06540	COG0494	nUDIX hydrolase
O3Y_RS06545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O3Y_RS06560	COG3106	COG3106 Predicted ATPase
O3Y_RS06565	COG3768	UPF0283 membrane protein
O3Y_RS06575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O3Y_RS06590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O3Y_RS06600	COG0471	metal ion transport
O3Y_RS06605	COG4191	Histidine kinase
O3Y_RS06605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3Y_RS06615	COG2990	Protein conserved in bacteria
O3Y_RS06620	COG3713	MltA-interacting MipA family protein
O3Y_RS06625	COG2205	protein histidine kinase activity
O3Y_RS06630	COG0745	RESPONSE REGULATOR receiver
O3Y_RS06665	COG1129	ABC transporter
O3Y_RS06705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O3Y_RS06710	COG0372	Belongs to the citrate synthase family
O3Y_RS06740	COG2195	Cleaves the N-terminal amino acid of tripeptides
O3Y_RS06750	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O3Y_RS06760	COG0625	glutathione transferase activity
O3Y_RS06765	COG3437	response regulator, receiver
O3Y_RS06785	COG3706	GGDEF domain
O3Y_RS06790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O3Y_RS06795	COG1254	Belongs to the acylphosphatase family
O3Y_RS06800	COG2920	part of a sulfur-relay system
O3Y_RS06805	COG0670	Belongs to the BI1 family
O3Y_RS06810	COG1126	abc transporter atp-binding protein
O3Y_RS06815	COG0765	amino acid transport
O3Y_RS06820	COG4597	amino acid ABC transporter
O3Y_RS06825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O3Y_RS06835	COG0561	phosphatase activity
O3Y_RS06840	COG0602	queuosine metabolic process
O3Y_RS06845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O3Y_RS06875	COG3706	GGDEF domain
O3Y_RS06880	COG0443	Heat shock 70 kDa protein
O3Y_RS06885	COG0443	Heat shock 70 kDa protein
O3Y_RS06925	COG1643	Atp-dependent helicase
O3Y_RS06935	COG0443	Heat shock 70 kDa protein
O3Y_RS06940	COG0095	Lipoate-protein ligase
O3Y_RS06950	COG0583	DNA-binding transcription factor activity
O3Y_RS06955	COG0477	Major facilitator Superfamily
O3Y_RS06960	COG0415	Belongs to the DNA photolyase family
O3Y_RS06975	COG0745	RESPONSE REGULATOR receiver
O3Y_RS06985	COG2198	Histidine kinase
O3Y_RS06985	COG0643	Histidine kinase
O3Y_RS06990	COG0784	Response regulator, receiver
O3Y_RS06990	COG2198	Histidine kinase
O3Y_RS06990	COG0643	Histidine kinase
O3Y_RS06995	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O3Y_RS07005	COG2201	protein-glutamate methylesterase activity
O3Y_RS07010	COG0835	chemotaxis
O3Y_RS07015	COG0840	transmembrane signaling receptor activity
O3Y_RS07015	COG3290	protein histidine kinase activity
O3Y_RS07020	COG0840	transmembrane signaling receptor activity
O3Y_RS07030	COG0513	Belongs to the DEAD box helicase family
O3Y_RS07040	COG1538	Outer membrane efflux protein
O3Y_RS07045	COG1566	PFAM secretion protein HlyD family protein
O3Y_RS07050	COG2814	Major facilitator Superfamily
O3Y_RS07060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O3Y_RS07070	COG3501	Rhs element vgr protein
O3Y_RS07080	COG3675	Pfam Lipase (class 3)
O3Y_RS07095	COG1280	lysine exporter protein (LysE YggA)
O3Y_RS07100	COG1115	amino acid carrier protein
O3Y_RS07115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O3Y_RS07125	COG1177	transmembrane transport
O3Y_RS07135	COG3842	ATPase activity
O3Y_RS07160	COG0589	response to stress
O3Y_RS07165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O3Y_RS07180	COG2217	Heavy metal translocating P-type atpase
O3Y_RS07190	COG2010	Cytochrome c
O3Y_RS07205	COG3278	Belongs to the heme-copper respiratory oxidase family
O3Y_RS07220	COG2205	protein histidine kinase activity
O3Y_RS07220	COG0784	Response regulator, receiver
O3Y_RS07245	COG2994	toxin metabolic process
O3Y_RS07250	COG3064	Membrane
O3Y_RS07250	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
O3Y_RS07250	COG1073	alpha beta
O3Y_RS07270	COG1476	TRANSCRIPTIONal
O3Y_RS07285	COG4128	Pfam Zonular occludens toxin
O3Y_RS07315	COG1476	TRANSCRIPTIONal
O3Y_RS07400	COG3120	sequence-specific DNA binding
O3Y_RS07405	COG1067	ATP-dependent peptidase activity
O3Y_RS07410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O3Y_RS07425	COG0488	(ABC) transporter
O3Y_RS07435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O3Y_RS07435	COG0116	Belongs to the methyltransferase superfamily
O3Y_RS07445	COG0167	dihydroorotate dehydrogenase activity
O3Y_RS07460	COG0308	aminopeptidase N
O3Y_RS07495	COG0641	radical SAM
O3Y_RS07575	COG4695	Portal protein
O3Y_RS07665	COG1428	Deoxynucleoside kinase
O3Y_RS07735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O3Y_RS07740	COG0308	aminopeptidase N
O3Y_RS07755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
O3Y_RS07760	COG1956	GAF domain-containing protein
O3Y_RS07765	COG1132	(ABC) transporter
O3Y_RS07770	COG2995	paraquat-inducible protein a
O3Y_RS07775	COG3008	intermembrane lipid transfer
O3Y_RS07785	COG2996	Protein conserved in bacteria
O3Y_RS07800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O3Y_RS07805	COG1666	GTP binding
O3Y_RS07810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O3Y_RS07825	COG0437	4 iron, 4 sulfur cluster binding
O3Y_RS07830	COG3383	formate dehydrogenase (NAD+) activity
O3Y_RS07830	COG0243	molybdopterin cofactor binding
O3Y_RS07860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O3Y_RS07865	COG0488	(ABC) transporter
O3Y_RS07870	COG3852	Histidine kinase
O3Y_RS07875	COG2204	response regulator
O3Y_RS07885	COG4662	Binding-protein-dependent transport system inner membrane component
O3Y_RS07890	COG3842	ATPase activity
O3Y_RS07895	COG0746	molybdenum cofactor guanylyltransferase activity
O3Y_RS07925	COG1940	carbohydrate kinase activity
O3Y_RS07930	COG3148	PFAM DTW domain containing protein
O3Y_RS07940	COG0840	transmembrane signaling receptor activity
O3Y_RS07945	COG0791	NLP P60 protein
O3Y_RS07955	COG3001	Fructosamine kinase
O3Y_RS07965	COG0534	Mate efflux family protein
O3Y_RS07975	COG1793	dna ligase
O3Y_RS07985	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
O3Y_RS07990	COG0848	biopolymer transport protein
O3Y_RS07995	COG0811	peptide transport
O3Y_RS08000	COG0811	peptide transport
O3Y_RS08015	COG1175	transmembrane transport
O3Y_RS08020	COG0395	ABC-type sugar transport system, permease component
O3Y_RS08025	COG3842	ATPase activity
O3Y_RS08030	COG1349	DNA-binding transcription factor activity
O3Y_RS08035	COG0584	glycerophosphoryl diester phosphodiesterase
O3Y_RS08040	COG2731	YhcH YjgK YiaL family protein
O3Y_RS08045	COG0251	oxidation-reduction process
O3Y_RS08050	COG1609	Transcriptional regulator
O3Y_RS08055	COG2723	6-phospho-beta-galactosidase activity
O3Y_RS08065	COG0583	DNA-binding transcription factor activity
O3Y_RS08085	COG0577	efflux transmembrane transporter activity
O3Y_RS08085	COG1136	(ABC) transporter
O3Y_RS08090	COG1136	(ABC) transporter
O3Y_RS08090	COG0577	efflux transmembrane transporter activity
O3Y_RS08095	COG1136	(ABC) transporter
O3Y_RS08095	COG4591	ABC-type transport system involved in lipoprotein release permease component
O3Y_RS08100	COG1294	oxidase, subunit
O3Y_RS08105	COG1271	oxidase subunit
O3Y_RS08145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O3Y_RS08155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O3Y_RS08175	COG0753	catalase activity
O3Y_RS08190	COG3527	Alpha-acetolactate decarboxylase
O3Y_RS08205	COG2200	EAL domain
O3Y_RS08205	COG2199	diguanylate cyclase activity
O3Y_RS08215	COG2017	converts alpha-aldose to the beta-anomer
O3Y_RS08220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O3Y_RS08225	COG1085	galactose-1-phosphate uridylyltransferase
O3Y_RS08265	COG0784	Response regulator, receiver
O3Y_RS08265	COG0835	chemotaxis
O3Y_RS08275	COG4565	transcriptional regulatory protein
O3Y_RS08280	COG3290	protein histidine kinase activity
O3Y_RS08295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_RS08315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O3Y_RS08320	COG3063	Type IV pilus biogenesis stability protein PilW
O3Y_RS08335	COG1451	nucleotide metabolic process
O3Y_RS08345	COG0583	DNA-binding transcription factor activity
O3Y_RS08370	COG1538	Outer membrane efflux protein
O3Y_RS08385	COG1748	Saccharopine dehydrogenase
O3Y_RS08395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O3Y_RS08405	COG0577	efflux transmembrane transporter activity
O3Y_RS08410	COG4181	ATPase activity
O3Y_RS08415	COG0534	Mate efflux family protein
O3Y_RS08420	COG0702	epimerase
O3Y_RS08430	COG2814	Major facilitator Superfamily
O3Y_RS08435	COG1187	pseudouridine synthase activity
O3Y_RS08440	COG1061	Type III restriction enzyme res subunit
O3Y_RS08460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O3Y_RS08465	COG2203	Gaf domain
O3Y_RS08465	COG3706	GGDEF domain
O3Y_RS08465	COG4251	negative regulation of phosphorylation
O3Y_RS08465	COG5001	Diguanylate cyclase
O3Y_RS08480	COG0840	transmembrane signaling receptor activity
O3Y_RS08510	COG4934	collagen metabolic process
O3Y_RS08525	COG0784	Response regulator, receiver
O3Y_RS08525	COG2205	protein histidine kinase activity
O3Y_RS08530	COG2239	Acts as a magnesium transporter
O3Y_RS08540	COG0814	amino acid
O3Y_RS08545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_RS08550	COG1131	(ABC) transporter
O3Y_RS08555	COG0842	Transport permease protein
O3Y_RS08565	COG3313	Fe-S protein
O3Y_RS08575	COG4134	Bacterial extracellular solute-binding protein
O3Y_RS08580	COG4135	transport system, permease component
O3Y_RS08585	COG4136	ATPase activity
O3Y_RS08590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O3Y_RS08595	COG0564	pseudouridine synthase activity
O3Y_RS08600	COG0733	neurotransmitter:sodium symporter activity
O3Y_RS08610	COG0626	cystathionine gamma-synthase activity
O3Y_RS08615	COG2818	Glycosylase
O3Y_RS08630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_RS08645	COG1842	Phage shock protein A
O3Y_RS08650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O3Y_RS08660	COG4168	peptide transport system, permease
O3Y_RS08675	COG4172	Belongs to the ABC transporter superfamily
O3Y_RS08690	COG1227	inorganic diphosphatase activity
O3Y_RS08710	COG0243	molybdopterin cofactor binding
O3Y_RS08715	COG3005	denitrification pathway
O3Y_RS08720	COG4459	periplasmic nitrate reductase
O3Y_RS08730	COG2116	formate transmembrane transporter activity
O3Y_RS08740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O3Y_RS08745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O3Y_RS08760	COG1607	acyl-coa hydrolase
O3Y_RS08765	COG2350	Protein conserved in bacteria
O3Y_RS08775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O3Y_RS08780	COG0583	DNA-binding transcription factor activity
O3Y_RS08795	COG0612	Peptidase, M16
O3Y_RS08800	COG5001	Diguanylate cyclase
O3Y_RS08805	COG1032	radical SAM domain protein
O3Y_RS08825	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
O3Y_RS08835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O3Y_RS08840	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O3Y_RS08845	COG0745	RESPONSE REGULATOR receiver
O3Y_RS08850	COG3381	protein complex oligomerization
O3Y_RS08855	COG1609	Transcriptional regulator
O3Y_RS08860	COG3070	regulator of competence-specific genes
O3Y_RS08880	COG0297	glycogen (starch) synthase activity
O3Y_RS08885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O3Y_RS08890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O3Y_RS08920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O3Y_RS08925	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O3Y_RS08950	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS08955	COG1309	transcriptional regulator
O3Y_RS08980	COG0668	transmembrane transport
O3Y_RS08985	COG2995	paraquat-inducible protein a
O3Y_RS08990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O3Y_RS08990	COG3008	intermembrane lipid transfer
O3Y_RS09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O3Y_RS09015	COG0582	viral genome integration into host DNA
O3Y_RS09025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O3Y_RS09045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
O3Y_RS09065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O3Y_RS09085	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
O3Y_RS09090	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
O3Y_RS09095	COG1737	Transcriptional regulator
O3Y_RS09100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O3Y_RS09105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
O3Y_RS09110	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
O3Y_RS09115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O3Y_RS09130	COG1940	carbohydrate kinase activity
O3Y_RS09135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O3Y_RS09140	COG4409	exo-alpha-(2->6)-sialidase activity
O3Y_RS09150	COG2003	Belongs to the UPF0758 family
O3Y_RS09170	COG3941	tape measure
O3Y_RS09210	COG0488	(ABC) transporter
O3Y_RS09290	COG0415	Belongs to the DNA photolyase family
O3Y_RS09300	COG4628	conserved protein (DUF2132)
O3Y_RS09305	COG3284	Transcriptional regulator
O3Y_RS09310	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS09320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_RS09325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_RS09330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_RS09340	COG2207	Transcriptional regulator
O3Y_RS09345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_RS09345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O3Y_RS09345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_RS09350	COG1482	cell wall glycoprotein biosynthetic process
O3Y_RS09360	COG0784	Response regulator, receiver
O3Y_RS09360	COG5002	protein histidine kinase activity
O3Y_RS09370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O3Y_RS09380	COG2885	chlorophyll binding
O3Y_RS09385	COG0823	Involved in the tonB-independent uptake of proteins
O3Y_RS09400	COG0811	peptide transport
O3Y_RS09405	COG0824	Thioesterase
O3Y_RS09410	COG3790	cyd operon protein YbgE
O3Y_RS09415	COG4890	Cyd operon protein YbgT
O3Y_RS09420	COG1294	oxidase, subunit
O3Y_RS09425	COG1271	oxidase subunit
O3Y_RS09435	COG0632	four-way junction helicase activity
O3Y_RS09440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O3Y_RS09445	COG0215	cysteine-tRNA ligase activity
O3Y_RS09450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O3Y_RS09455	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_RS09460	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O3Y_RS09465	COG3012	SEC-C Motif Domain Protein
O3Y_RS09470	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
O3Y_RS09475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O3Y_RS09480	COG1199	ATP-dependent helicase activity
O3Y_RS09485	COG0730	response to heat
O3Y_RS09490	COG3923	Primosomal replication protein n
O3Y_RS09500	COG0840	transmembrane signaling receptor activity
O3Y_RS09505	COG0708	Exodeoxyribonuclease III
O3Y_RS09510	COG4160	amino acid transport
O3Y_RS09535	COG1882	Formate acetyltransferase
O3Y_RS09545	COG0840	transmembrane signaling receptor activity
O3Y_RS09550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O3Y_RS09560	COG3013	Belongs to the UPF0304 family
O3Y_RS09565	COG2766	serine protein kinase
O3Y_RS09570	COG2718	Belongs to the UPF0229 family
O3Y_RS09575	COG2719	SpoVR family
O3Y_RS09580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
O3Y_RS09585	COG2835	tetraacyldisaccharide 4'-kinase activity
O3Y_RS09590	COG1663	tetraacyldisaccharide 4'-kinase activity
O3Y_RS09595	COG1132	(ABC) transporter
O3Y_RS09600	COG2333	competence protein COMEC
O3Y_RS09600	COG0658	competence protein
O3Y_RS09610	COG4591	ABC-type transport system involved in lipoprotein release permease component
O3Y_RS09615	COG1136	(ABC) transporter
O3Y_RS09620	COG4591	ABC-type transport system involved in lipoprotein release permease component
O3Y_RS09630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O3Y_RS09650	COG1252	NADH dehydrogenase
O3Y_RS09655	COG3150	esterase
O3Y_RS09680	COG0537	adenosine 5'-monophosphoramidase activity
O3Y_RS09695	COG2186	Transcriptional regulator
O3Y_RS09700	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O3Y_RS09705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O3Y_RS09710	COG1674	ftsk spoiiie
O3Y_RS09720	COG0686	Belongs to the AlaDH PNT family
O3Y_RS09730	COG0583	DNA-binding transcription factor activity
O3Y_RS09750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
O3Y_RS09755	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
O3Y_RS09760	COG0776	regulation of translation
O3Y_RS09765	COG0539	negative regulation of cytoplasmic translation
O3Y_RS09770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O3Y_RS09775	COG1555	photosystem II stabilization
O3Y_RS09780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O3Y_RS09785	COG0776	regulation of translation
O3Y_RS09790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O3Y_RS09795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O3Y_RS09805	COG0544	peptidyl-prolyl cis-trans isomerase activity
O3Y_RS09815	COG4191	Histidine kinase
O3Y_RS09825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
O3Y_RS09830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
O3Y_RS09835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O3Y_RS09840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O3Y_RS09855	COG5001	Diguanylate cyclase
O3Y_RS09855	COG3300	MHYT domain
O3Y_RS09865	COG4589	Belongs to the CDS family
O3Y_RS09900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O3Y_RS09910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_RS09925	COG0243	molybdopterin cofactor binding
O3Y_RS09930	COG3005	denitrification pathway
O3Y_RS09935	COG3325	Belongs to the glycosyl hydrolase 18 family
O3Y_RS09935	COG3469	chitinase activity
O3Y_RS09940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O3Y_RS09950	COG2951	lytic endotransglycosylase activity
O3Y_RS09955	COG3100	YcgL domain-containing protein
O3Y_RS09960	COG0850	regulation of cytokinetic process
O3Y_RS09965	COG2894	cell division
O3Y_RS09970	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O3Y_RS09975	COG3015	lipoprotein NlpE involved in copper resistance
O3Y_RS09995	COG0477	Major facilitator Superfamily
O3Y_RS10005	COG0840	transmembrane signaling receptor activity
O3Y_RS10010	COG1396	sequence-specific DNA binding
O3Y_RS10015	COG3135	benzoate transporter
O3Y_RS10035	COG0596	Alpha beta hydrolase
O3Y_RS10040	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O3Y_RS10045	COG1169	isochorismate synthase
O3Y_RS10050	COG0436	Aminotransferase
O3Y_RS10055	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
O3Y_RS10060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O3Y_RS10080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
O3Y_RS10085	COG0318	PFAM AMP-dependent synthetase and ligase
O3Y_RS10090	COG0596	Alpha beta hydrolase
O3Y_RS10105	COG1214	PFAM Peptidase M22, glycoprotease
O3Y_RS10110	COG1199	ATP-dependent helicase activity
O3Y_RS10120	COG0788	formyltetrahydrofolate deformylase activity
O3Y_RS10125	COG1902	pentaerythritol trinitrate reductase activity
O3Y_RS10125	COG0446	pyridine nucleotide-disulphide oxidoreductase
O3Y_RS10130	COG0616	signal peptide processing
O3Y_RS10135	COG0252	asparaginase activity
O3Y_RS10140	COG3139	Protein of unknown function (DUF1315)
O3Y_RS10150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_RS10155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O3Y_RS10160	COG0676	glucose-6-phosphate 1-epimerase activity
O3Y_RS10170	COG2226	methyltransferase
O3Y_RS10185	COG0835	chemotaxis
O3Y_RS10185	COG0784	Response regulator, receiver
O3Y_RS10190	COG1940	carbohydrate kinase activity
O3Y_RS10200	COG4667	esterase of the alpha-beta hydrolase superfamily
O3Y_RS10215	COG0733	neurotransmitter:sodium symporter activity
O3Y_RS10220	COG1263	PTS System
O3Y_RS10220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O3Y_RS10225	COG0084	hydrolase, TatD family'
O3Y_RS10235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O3Y_RS10240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O3Y_RS10245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O3Y_RS10250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O3Y_RS10255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O3Y_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
O3Y_RS10270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O3Y_RS10275	COG0416	fatty acid biosynthetic process
O3Y_RS10280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O3Y_RS10285	COG1399	metal-binding, possibly nucleic acid-binding protein
O3Y_RS10290	COG0424	maF-like protein
O3Y_RS10295	COG0564	pseudouridine synthase activity
O3Y_RS10305	COG1530	ribonuclease E activity
O3Y_RS10310	COG0659	secondary active sulfate transmembrane transporter activity
O3Y_RS10320	COG1454	alcohol dehydrogenase
O3Y_RS10320	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS10325	COG2095	MarC family integral membrane protein
O3Y_RS10330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O3Y_RS10335	COG1757	Na H antiporter
O3Y_RS10345	COG3081	Nucleoid-associated protein
O3Y_RS10350	COG3082	Protein of unknown function (DUF1414)
O3Y_RS10355	COG3083	sulfuric ester hydrolase activity
O3Y_RS10370	COG0123	including yeast histone deacetylase and acetoin utilization protein
O3Y_RS10375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O3Y_RS10380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O3Y_RS10400	COG2853	Lipoprotein
O3Y_RS10410	COG3088	subunit of a heme lyase
O3Y_RS10410	COG4235	cytochrome complex assembly
O3Y_RS10415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O3Y_RS10420	COG1138	Cytochrome C-type biogenesis protein
O3Y_RS10425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
O3Y_RS10435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O3Y_RS10440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O3Y_RS10445	COG4133	protoheme IX ABC transporter activity
O3Y_RS10455	COG0835	chemotaxis
O3Y_RS10465	COG1192	Involved in chromosome partitioning
O3Y_RS10470	COG2201	protein-glutamate methylesterase activity
O3Y_RS10475	COG0643	Histidine kinase
O3Y_RS10475	COG0784	Response regulator, receiver
O3Y_RS10475	COG2198	Histidine kinase
O3Y_RS10480	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
O3Y_RS10510	COG2062	phosphohistidine phosphatase, SixA
O3Y_RS10515	COG1025	Belongs to the peptidase M16 family
O3Y_RS10525	COG0018	arginyl-trna synthetase
O3Y_RS10545	COG1918	ferrous iron import across plasma membrane
O3Y_RS10550	COG4977	sequence-specific DNA binding
O3Y_RS10555	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
O3Y_RS10560	COG1121	(ABC) transporter
O3Y_RS10565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O3Y_RS10575	COG0045	succinate-CoA ligase (ADP-forming) activity
O3Y_RS10580	COG0508	dehydrogenase complex catalyzes the overall conversion of
O3Y_RS10585	COG0567	Dehydrogenase, E1 component
O3Y_RS10595	COG1053	succinate dehydrogenase
O3Y_RS10600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O3Y_RS10605	COG2009	succinate dehydrogenase
O3Y_RS10610	COG0372	Belongs to the citrate synthase family
O3Y_RS10615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O3Y_RS10625	COG0033	Phosphoglucomutase
O3Y_RS10630	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
O3Y_RS10635	COG0596	Alpha beta hydrolase
O3Y_RS10650	COG1346	cytolysis
O3Y_RS10660	COG0583	DNA-binding transcription factor activity
O3Y_RS10670	COG0735	belongs to the Fur family
O3Y_RS10675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O3Y_RS10680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O3Y_RS10685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O3Y_RS10695	COG0431	NADPH-dependent FMN reductase
O3Y_RS10705	COG3101	peptidyl-lysine hydroxylation
O3Y_RS10710	COG2860	membrane
O3Y_RS10715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O3Y_RS10725	COG2890	protein-(glutamine-N5) methyltransferase activity
O3Y_RS10730	COG2840	Smr protein MutS2
O3Y_RS10740	COG1684	flagellar biosynthetic protein fliR
O3Y_RS10745	COG1987	bacterial-type flagellum assembly
O3Y_RS10770	COG1580	Controls the rotational direction of flagella during chemotaxis
O3Y_RS10790	COG1317	bacterial-type flagellum organization
O3Y_RS10795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O3Y_RS10805	COG1677	Flagellar hook-basal body complex protein FliE
O3Y_RS10825	COG1516	flagellar protein fliS
O3Y_RS10835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O3Y_RS10840	COG1334	flagellar protein FlaG
O3Y_RS10845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_RS10850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_RS10855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_RS10860	COG2837	iron assimilation
O3Y_RS10880	COG1393	Belongs to the ArsC family
O3Y_RS10890	COG1876	peptidase activity
O3Y_RS10900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
O3Y_RS10915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O3Y_RS10935	COG4783	chaperone-mediated protein folding
O3Y_RS10940	COG1393	Belongs to the ArsC family
O3Y_RS10960	COG2233	PERMEase
O3Y_RS10965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O3Y_RS10970	COG0737	Belongs to the 5'-nucleotidase family
O3Y_RS10975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
O3Y_RS10980	COG2912	Transglutaminase-like superfamily
O3Y_RS10990	COG2890	protein-(glutamine-N5) methyltransferase activity
O3Y_RS10995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O3Y_RS11000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O3Y_RS11005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O3Y_RS11010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O3Y_RS11015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O3Y_RS11020	COG0193	aminoacyl-tRNA hydrolase activity
O3Y_RS11025	COG0012	GTP binding
O3Y_RS11110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_RS11115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O3Y_RS11135	COG3951	Flagellar rod assembly protein muramidase FlgJ
O3Y_RS11135	COG1705	Flagellar rod assembly protein muramidase FlgJ
O3Y_RS11140	COG1706	bacterial-type flagellum-dependent cell motility
O3Y_RS11145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
O3Y_RS11155	COG4787	bacterial-type flagellum-dependent cell motility
O3Y_RS11160	COG1749	Flagellar hook protein flgE
O3Y_RS11175	COG1815	bacterial-type flagellum-dependent cell motility
O3Y_RS11180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O3Y_RS11185	COG0835	chemotaxis
O3Y_RS11185	COG0784	Response regulator, receiver
O3Y_RS11220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O3Y_RS11220	COG2226	methyltransferase
O3Y_RS11220	COG3433	isochorismatase activity
O3Y_RS11225	COG2375	cellular response to nickel ion
O3Y_RS11230	COG4774	siderophore transport
O3Y_RS11230	COG1629	transport
O3Y_RS11245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O3Y_RS11250	COG2217	Heavy metal translocating P-type atpase
O3Y_RS11250	COG2608	mercury ion transmembrane transporter activity
O3Y_RS11265	COG3735	TraB family
O3Y_RS11280	COG2840	Smr protein MutS2
O3Y_RS11285	COG1187	pseudouridine synthase activity
O3Y_RS11295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O3Y_RS11300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O3Y_RS11305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O3Y_RS11310	COG0121	glutamine amidotransferase
O3Y_RS11315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O3Y_RS11335	COG0328	RNA-DNA hybrid ribonuclease activity
O3Y_RS11340	COG2226	methyltransferase
O3Y_RS11345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O3Y_RS11350	COG0741	lytic transglycosylase activity
O3Y_RS11350	COG1388	LysM domain
O3Y_RS11355	COG3021	interspecies interaction between organisms
O3Y_RS11360	COG0347	Belongs to the P(II) protein family
O3Y_RS11365	COG3479	Phenolic acid decarboxylase
O3Y_RS11375	COG0037	tRNA processing
O3Y_RS11380	COG0825	malonyl-CoA metabolic process
O3Y_RS11385	COG0587	DNA-directed DNA polymerase activity
O3Y_RS11390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O3Y_RS11395	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_RS11400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_RS11405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O3Y_RS11410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O3Y_RS11415	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
O3Y_RS11425	COG0750	zinc metalloprotease
O3Y_RS11430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O3Y_RS11435	COG0575	Belongs to the CDS family
O3Y_RS11440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O3Y_RS11445	COG0233	cytoplasmic translational termination
O3Y_RS11450	COG0528	UMP kinase activity
O3Y_RS11455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O3Y_RS11460	COG0052	Belongs to the universal ribosomal protein uS2 family
O3Y_RS11465	COG0024	Methionine aminopeptidase
O3Y_RS11470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O3Y_RS11480	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O3Y_RS11485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O3Y_RS11490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O3Y_RS11495	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O3Y_RS11510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O3Y_RS11510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O3Y_RS11515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O3Y_RS11520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O3Y_RS11525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O3Y_RS11535	COG1073	alpha beta
O3Y_RS11540	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
O3Y_RS11545	COG2252	PERMEase
O3Y_RS11550	COG2195	Cleaves the N-terminal amino acid of tripeptides
O3Y_RS11555	COG4067	protein conserved in archaea
O3Y_RS11555	COG0189	ligase activity
O3Y_RS11560	COG0189	ligase activity
O3Y_RS11570	COG0733	neurotransmitter:sodium symporter activity
O3Y_RS11575	COG3706	GGDEF domain
O3Y_RS11595	COG1477	protein flavinylation
O3Y_RS11600	COG2871	sodium ion transport
O3Y_RS11605	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_RS11610	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_RS11615	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_RS11620	COG1805	sodium ion transport
O3Y_RS11625	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O3Y_RS11630	COG0271	Belongs to the BolA IbaG family
O3Y_RS11635	COG2813	Specifically methylates the guanine in position
O3Y_RS11645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O3Y_RS11650	COG2211	Major facilitator Superfamily
O3Y_RS11660	COG1595	DNA-templated transcription, initiation
O3Y_RS11670	COG3248	Nucleoside-binding outer membrane protein
O3Y_RS11675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O3Y_RS11680	COG0693	protein deglycase activity
O3Y_RS11685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O3Y_RS11690	COG2166	iron-sulfur cluster assembly
O3Y_RS11695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O3Y_RS11700	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
O3Y_RS11710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O3Y_RS11710	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O3Y_RS11725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O3Y_RS11730	COG1074	ATP-dependent DNA helicase activity
O3Y_RS11735	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O3Y_RS11750	COG3141	response to X-ray
O3Y_RS11755	COG2171	N-acyltransferase activity
O3Y_RS11765	COG0456	acetyltransferase
O3Y_RS11770	COG0569	domain protein
O3Y_RS11770	COG0189	ligase activity
O3Y_RS11785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O3Y_RS11790	COG1609	Transcriptional regulator
O3Y_RS11795	COG3250	beta-galactosidase activity
O3Y_RS11810	COG1022	Amp-dependent synthetase and ligase
O3Y_RS11815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O3Y_RS11820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O3Y_RS11830	COG0560	Phosphoserine phosphatase
O3Y_RS11840	COG0813	purine-nucleoside phosphorylase activity
O3Y_RS11845	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O3Y_RS11850	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O3Y_RS11855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O3Y_RS11865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O3Y_RS11870	COG0084	hydrolase, TatD family'
O3Y_RS11875	COG3022	response to hydroperoxide
O3Y_RS11880	COG1115	amino acid carrier protein
O3Y_RS11895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O3Y_RS11900	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O3Y_RS11905	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
O3Y_RS11910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O3Y_RS11930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O3Y_RS11940	COG0745	RESPONSE REGULATOR receiver
O3Y_RS11945	COG5002	protein histidine kinase activity
O3Y_RS11945	COG2198	Histidine kinase
O3Y_RS11945	COG0784	Response regulator, receiver
O3Y_RS11950	COG2203	Gaf domain
O3Y_RS11950	COG5001	Diguanylate cyclase
O3Y_RS11950	COG3706	GGDEF domain
O3Y_RS11950	COG4251	negative regulation of phosphorylation
O3Y_RS11955	COG1242	4 iron, 4 sulfur cluster binding
O3Y_RS11960	COG0067	glutamate synthase
O3Y_RS11960	COG0069	glutamate synthase activity
O3Y_RS11960	COG0070	glutamate synthase
O3Y_RS11970	COG0070	glutamate synthase
O3Y_RS11970	COG0069	glutamate synthase activity
O3Y_RS11970	COG0067	glutamate synthase
O3Y_RS11975	COG0493	'glutamate synthase
O3Y_RS11985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O3Y_RS11995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O3Y_RS12000	COG2860	membrane
O3Y_RS12005	COG0583	DNA-binding transcription factor activity
O3Y_RS12010	COG0730	response to heat
O3Y_RS12020	COG4172	Belongs to the ABC transporter superfamily
O3Y_RS12040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O3Y_RS12045	COG0505	Belongs to the CarA family
O3Y_RS12055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O3Y_RS12060	COG0494	nUDIX hydrolase
O3Y_RS12070	COG0653	protein targeting
O3Y_RS12080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
O3Y_RS12085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O3Y_RS12090	COG0849	cell division
O3Y_RS12095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O3Y_RS12100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O3Y_RS12110	COG0772	Belongs to the SEDS family
O3Y_RS12115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O3Y_RS12125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O3Y_RS12130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O3Y_RS12135	COG0768	penicillin binding
O3Y_RS12140	COG3116	cell division
O3Y_RS12150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_RS12155	COG0508	dehydrogenase complex catalyzes the overall conversion of
O3Y_RS12160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O3Y_RS12165	COG2186	Transcriptional regulator
O3Y_RS12170	COG0737	Belongs to the 5'-nucleotidase family
O3Y_RS12175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O3Y_RS12180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O3Y_RS12185	COG4974	Belongs to the 'phage' integrase family
O3Y_RS12190	COG0716	FMN binding
O3Y_RS12210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_RS12215	COG1459	type II secretion system
O3Y_RS12225	COG0237	dephospho-CoA kinase activity
O3Y_RS12230	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
O3Y_RS12240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O3Y_RS12245	COG0187	DNA topoisomerase II activity
O3Y_RS12250	COG3150	esterase
O3Y_RS12260	COG3151	Protein conserved in bacteria
O3Y_RS12265	COG0494	nUDIX hydrolase
O3Y_RS12270	COG1538	Outer membrane efflux protein
O3Y_RS12280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O3Y_RS12285	COG0840	transmembrane signaling receptor activity
O3Y_RS12290	COG3025	triphosphatase activity
O3Y_RS12295	COG1392	Phosphate transport regulator
O3Y_RS12300	COG0306	phosphate transporter
O3Y_RS12305	COG4991	sh3 domain protein
O3Y_RS12315	COG3267	Type II secretory pathway component ExeA
O3Y_RS12315	COG3409	Peptidoglycan-binding domain 1 protein
O3Y_RS12325	COG0148	phosphopyruvate hydratase activity
O3Y_RS12330	COG0504	CTP synthase activity
O3Y_RS12335	COG3956	TIGRFAM MazG family protein
O3Y_RS12340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O3Y_RS12355	COG5001	Diguanylate cyclase
O3Y_RS12375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O3Y_RS12380	COG1381	Involved in DNA repair and RecF pathway recombination
O3Y_RS12385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O3Y_RS12400	COG0481	GTPase activity
O3Y_RS12405	COG3086	response to oxidative stress
O3Y_RS12420	COG1595	DNA-templated transcription, initiation
O3Y_RS12430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O3Y_RS12440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
O3Y_RS12455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_RS12460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O3Y_RS12465	COG3079	Belongs to the UPF0149 family
O3Y_RS12470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O3Y_RS12475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O3Y_RS12480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O3Y_RS12485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O3Y_RS12490	COG0440	acetolactate synthase activity
O3Y_RS12495	COG0028	Belongs to the TPP enzyme family
O3Y_RS12500	COG1022	Amp-dependent synthetase and ligase
O3Y_RS12505	COG0583	DNA-binding transcription factor activity
O3Y_RS12530	COG0473	3-isopropylmalate dehydrogenase activity
O3Y_RS12535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O3Y_RS12540	COG0066	3-isopropylmalate dehydratase activity
O3Y_RS12585	COG3437	response regulator, receiver
O3Y_RS12600	COG0795	lipopolysaccharide-transporting ATPase activity
O3Y_RS12605	COG0795	lipopolysaccharide-transporting ATPase activity
O3Y_RS12610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O3Y_RS12615	COG2927	DNA polymerase III (CHI subunit)
O3Y_RS12620	COG0525	valine-tRNA ligase activity
O3Y_RS12625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O3Y_RS12630	COG0564	pseudouridine synthase activity
O3Y_RS12645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O3Y_RS12660	COG0540	Belongs to the ATCase OTCase family
O3Y_RS12670	COG0251	oxidation-reduction process
O3Y_RS12680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O3Y_RS12685	COG5007	Belongs to the BolA IbaG family
O3Y_RS12695	COG2854	intermembrane phospholipid transfer
O3Y_RS12700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O3Y_RS12705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O3Y_RS12710	COG1127	ABC transporter
O3Y_RS12725	COG0517	IMP dehydrogenase activity
O3Y_RS12725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O3Y_RS12740	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O3Y_RS12745	COG1137	ATPase activity
O3Y_RS12755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O3Y_RS12760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_RS12765	COG1660	Displays ATPase and GTPase activities
O3Y_RS12770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O3Y_RS12775	COG2239	Acts as a magnesium transporter
O3Y_RS12780	COG0312	modulator of DNA gyrase
O3Y_RS12785	COG3028	Belongs to the UPF0307 family
O3Y_RS12790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
O3Y_RS12795	COG1178	ABC-type Fe3 transport system permease component
O3Y_RS12805	COG0163	prenyltransferase activity
O3Y_RS12810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O3Y_RS12825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O3Y_RS12830	COG2105	PFAM AIG2 family protein
O3Y_RS12840	COG0729	surface antigen
O3Y_RS12845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O3Y_RS12850	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
O3Y_RS12865	COG1136	(ABC) transporter
O3Y_RS12885	COG0529	Catalyzes the synthesis of activated sulfate
O3Y_RS12900	COG1648	precorrin-2 dehydrogenase activity
O3Y_RS12900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O3Y_RS12905	COG0737	Belongs to the 5'-nucleotidase family
O3Y_RS12915	COG0513	Belongs to the DEAD box helicase family
O3Y_RS12920	COG2153	protein acetylation
O3Y_RS12925	COG0697	spore germination
O3Y_RS12930	COG3061	Opacity-associated protein A
O3Y_RS12930	COG3266	domain, Protein
O3Y_RS12935	COG0545	Peptidyl-prolyl cis-trans isomerase
O3Y_RS12945	COG0203	ribosomal protein L17
O3Y_RS12950	COG0202	RNA polymerase activity
O3Y_RS12955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O3Y_RS12960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O3Y_RS12965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O3Y_RS12970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O3Y_RS12975	COG0201	protein transport
O3Y_RS12985	COG1841	ribosomal large subunit assembly
O3Y_RS12990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O3Y_RS12995	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O3Y_RS13005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O3Y_RS13010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O3Y_RS13015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O3Y_RS13020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O3Y_RS13025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O3Y_RS13030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O3Y_RS13035	COG0255	Belongs to the universal ribosomal protein uL29 family
O3Y_RS13040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O3Y_RS13045	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O3Y_RS13050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O3Y_RS13055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O3Y_RS13060	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O3Y_RS13065	COG0089	rRNA binding
O3Y_RS13070	COG0088	Forms part of the polypeptide exit tunnel
O3Y_RS13075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O3Y_RS13080	COG0051	transcription antitermination factor activity, RNA binding
O3Y_RS13085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O3Y_RS13090	COG0557	exoribonuclease II activity
O3Y_RS13095	COG3083	sulfuric ester hydrolase activity
O3Y_RS13100	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
O3Y_RS13115	COG1047	Peptidyl-prolyl cis-trans
O3Y_RS13130	COG2249	NAD(P)H dehydrogenase (quinone) activity
O3Y_RS13135	COG0488	(ABC) transporter
O3Y_RS13145	COG0429	hydrolase of the alpha beta-hydrolase fold
O3Y_RS13155	COG3954	Phosphoribulokinase
O3Y_RS13170	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS13180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O3Y_RS13190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O3Y_RS13205	COG0180	Tryptophanyl-tRNA synthetase
O3Y_RS13210	COG0546	phosphoglycolate phosphatase activity
O3Y_RS13215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O3Y_RS13220	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O3Y_RS13230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O3Y_RS13235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O3Y_RS13265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O3Y_RS13275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O3Y_RS13275	COG0678	peroxiredoxin activity
O3Y_RS13280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_RS13290	COG0165	Argininosuccinate lyase
O3Y_RS13295	COG0137	argininosuccinate synthase activity
O3Y_RS13300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O3Y_RS13305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O3Y_RS13310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O3Y_RS13315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O3Y_RS13325	COG1045	serine acetyltransferase
O3Y_RS13330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O3Y_RS13335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O3Y_RS13340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O3Y_RS13345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
O3Y_RS13350	COG1053	succinate dehydrogenase
O3Y_RS13355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O3Y_RS13360	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O3Y_RS13370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O3Y_RS13375	COG1509	lysine 2,3-aminomutase activity
O3Y_RS13385	COG0459	protein refolding
O3Y_RS13390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O3Y_RS13415	COG0149	triose-phosphate isomerase activity
O3Y_RS13420	COG0534	Mate efflux family protein
O3Y_RS13425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O3Y_RS13430	COG1575	Belongs to the MenA family. Type 1 subfamily
O3Y_RS13435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O3Y_RS13440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O3Y_RS13445	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O3Y_RS13450	COG1609	Transcriptional regulator
O3Y_RS13455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O3Y_RS13460	COG0254	rRNA binding
O3Y_RS13465	COG0281	malic enzyme
O3Y_RS13470	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
O3Y_RS13475	COG0626	cystathionine gamma-synthase activity
O3Y_RS13480	COG0527	aspartate kinase activity
O3Y_RS13480	COG0460	homoserine dehydrogenase
O3Y_RS13485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O3Y_RS13490	COG3074	FtsZ-dependent cytokinesis
O3Y_RS13495	COG1494	fructose-1,6-bisphosphatase
O3Y_RS13500	COG0205	6-phosphofructokinase activity
O3Y_RS13505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O3Y_RS13515	COG0745	RESPONSE REGULATOR receiver
O3Y_RS13520	COG2205	protein histidine kinase activity
O3Y_RS13530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O3Y_RS13535	COG3030	protein affecting phage T7 exclusion by the F plasmid
O3Y_RS13540	COG3706	GGDEF domain
O3Y_RS13545	COG1027	Aspartate ammonia-lyase
O3Y_RS13550	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O3Y_RS13565	COG4232	protein-disulfide reductase activity
O3Y_RS13585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O3Y_RS13590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O3Y_RS13595	COG0194	GDP metabolic process
O3Y_RS13600	COG1758	RNA polymerase activity
O3Y_RS13605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O3Y_RS13610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O3Y_RS13615	COG2233	PERMEase
O3Y_RS13630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O3Y_RS13635	COG2183	response to ionizing radiation
O3Y_RS13645	COG0596	Alpha beta hydrolase
O3Y_RS13650	COG1040	competence protein
O3Y_RS13660	COG0494	nUDIX hydrolase
O3Y_RS13665	COG1218	3'(2'),5'-bisphosphate nucleotidase
O3Y_RS13675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O3Y_RS13680	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O3Y_RS13685	COG3156	type II secretion system protein K
O3Y_RS13690	COG4795	General secretion pathway protein
O3Y_RS13695	COG2165	general secretion pathway protein
O3Y_RS13700	COG2165	general secretion pathway protein
O3Y_RS13705	COG2165	general secretion pathway protein
O3Y_RS13710	COG1459	type II secretion system
O3Y_RS13715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O3Y_RS13725	COG3031	protein transport across the cell outer membrane
O3Y_RS13730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O3Y_RS13735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O3Y_RS13740	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O3Y_RS13750	COG0456	acetyltransferase
O3Y_RS13755	COG1490	D-aminoacyl-tRNA deacylase activity
O3Y_RS13760	COG1295	ribonuclease BN
O3Y_RS13770	COG1217	gtp-binding protein TYPA
O3Y_RS13780	COG0174	glutamine synthetase
O3Y_RS13790	COG3852	Histidine kinase
O3Y_RS13800	COG3300	MHYT domain
O3Y_RS13800	COG5001	Diguanylate cyclase
O3Y_RS13805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O3Y_RS13885	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
O3Y_RS13890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O3Y_RS13895	COG1739	Uncharacterized protein family UPF0029
O3Y_RS13905	COG0183	Belongs to the thiolase family
O3Y_RS13910	COG0583	DNA-binding transcription factor activity
O3Y_RS13915	COG2814	Major facilitator Superfamily
O3Y_RS13920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O3Y_RS13925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O3Y_RS13930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O3Y_RS13935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O3Y_RS13940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O3Y_RS13945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O3Y_RS13950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O3Y_RS13960	COG0356	it plays a direct role in the translocation of protons across the membrane
O3Y_RS13965	COG3312	ion transport
O3Y_RS13970	COG1475	DNA binding
O3Y_RS13975	COG1192	Involved in chromosome partitioning
O3Y_RS13985	COG0445	tRNA wobble uridine modification
O3Y_RS14000	COG0706	membrane insertase activity
O3Y_RS14030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O3Y_RS14135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O3Y_RS14190	COG0408	coproporphyrinogen oxidase activity
O3Y_RS14290	COG1528	Iron-storage protein
O3Y_RS14305	COG1322	Protein conserved in bacteria
O3Y_RS14420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_RS14420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O3Y_RS14510	COG3287	FIST C domain
O3Y_RS14510	COG2200	EAL domain
O3Y_RS14510	COG2199	diguanylate cyclase activity
O3Y_RS14565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_RS14595	COG4206	TonB-dependent receptor
O3Y_RS14785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O3Y_RS14835	COG0514	ATP-dependent DNA helicase (RecQ)
O3Y_RS14865	COG4774	siderophore transport
O3Y_RS15270	COG0129	dihydroxy-acid dehydratase activity
O3Y_RS15420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O3Y_RS15540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O3Y_RS15550	COG0250	Participates in transcription elongation, termination and antitermination
O3Y_RS15575	COG0085	RNA polymerase activity
O3Y_RS15585	COG0085	RNA polymerase activity
O3Y_RS15620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O3Y_RS15630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O3Y_RS15785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O3Y_RS15815	COG0330	HflC and HflK could
O3Y_RS15865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O3Y_RS15880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O3Y_RS16005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O3Y_RS16090	COG1410	methionine synthase
O3Y_RS16090	COG0646	methionine synthase
O3Y_RS16295	COG1459	type II secretion system
O3Y_RS16325	COG1077	Cell shape determining protein MreB Mrl
O3Y_RS16860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O3Y_RS16865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O3Y_RS17140	COG1643	Atp-dependent helicase
O3Y_RS17320	COG2027	D-alanyl-D-alanine carboxypeptidase
O3Y_RS17405	COG1185	polyribonucleotide nucleotidyltransferase activity
O3Y_RS17525	COG3290	protein histidine kinase activity
O3Y_RS17525	COG3829	transcription factor binding
O3Y_RS17575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O3Y_RS17685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O3Y_RS17810	COG0248	Ppx GppA phosphatase
O3Y_RS17985	COG0519	Catalyzes the synthesis of GMP from XMP
O3Y_RS17985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O3Y_RS18120	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
O3Y_RS18250	COG1012	belongs to the aldehyde dehydrogenase family
O3Y_RS18305	COG3710	Transcriptional regulator
O3Y_RS18475	COG0443	Heat shock 70 kDa protein
O3Y_RS18485	COG0484	heat shock protein binding
O3Y_RS18910	COG0495	leucyl-tRNA aminoacylation
O3Y_RS19050	COG0367	asparagine synthase