locus-tag	class	description
HPY16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY16_RS00010	COG0592	DNA-directed DNA polymerase activity
HPY16_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY16_RS00020	COG0187	DNA topoisomerase II activity
HPY16_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY16_RS00035	COG3977	Valine--pyruvate aminotransferase
HPY16_RS00040	COG0751	glycine-tRNA ligase activity
HPY16_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY16_RS00050	COG2119	membrane
HPY16_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY16_RS00070	COG0604	alcohol dehydrogenase
HPY16_RS00080	COG0129	dihydroxy-acid dehydratase activity
HPY16_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY16_RS00100	COG0606	chelatase, subunit chli
HPY16_RS00105	COG0204	Acyl-transferase
HPY16_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY16_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY16_RS00125	COG3084	Protein conserved in bacteria
HPY16_RS00130	COG4326	sporulation control protein
HPY16_RS00135	COG1272	protein, Hemolysin III
HPY16_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY16_RS00150	COG0569	domain protein
HPY16_RS00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY16_RS00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY16_RS00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY16_RS00165	COG0242	peptide deformylase activity
HPY16_RS00170	COG1652	LysM domain
HPY16_RS00175	COG0758	DNA mediated transformation
HPY16_RS00180	COG2922	Belongs to the Smg family
HPY16_RS00185	COG0551	DNA topoisomerase type I activity
HPY16_RS00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY16_RS00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY16_RS00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY16_RS00205	COG0408	coproporphyrinogen oxidase activity
HPY16_RS00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY16_RS00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY16_RS00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY16_RS00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY16_RS00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY16_RS00280	COG2104	thiamine diphosphate biosynthetic process
HPY16_RS00285	COG2022	thiamine diphosphate biosynthetic process
HPY16_RS00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY16_RS00295	COG0006	proline dipeptidase activity
HPY16_RS00295	COG0006	proline dipeptidase activity
HPY16_RS00315	COG1522	sequence-specific DNA binding
HPY16_RS00320	COG5002	protein histidine kinase activity
HPY16_RS00320	COG5001	Diguanylate cyclase
HPY16_RS00340	COG0589	response to stress
HPY16_RS00345	COG1528	Iron-storage protein
HPY16_RS00355	COG2081	HI0933 family
HPY16_RS00365	COG1322	Protein conserved in bacteria
HPY16_RS00370	COG2226	methyltransferase
HPY16_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY16_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY16_RS00395	COG0805	protein transport
HPY16_RS00400	COG1858	cytochrome C peroxidase
HPY16_RS00405	COG0534	Mate efflux family protein
HPY16_RS00420	COG2937	Belongs to the GPAT DAPAT family
HPY16_RS00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY16_RS00430	COG3161	chorismate lyase activity
HPY16_RS00435	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY16_RS00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY16_RS00455	COG0084	hydrolase, TatD family'
HPY16_RS00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY16_RS00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY16_RS00490	COG3078	GTPase activator activity
HPY16_RS00510	COG2959	enzyme of heme biosynthesis
HPY16_RS00515	COG1587	Uroporphyrinogen-III synthase
HPY16_RS00520	COG0181	hydroxymethylbilane synthase activity
HPY16_RS00530	COG1965	Belongs to the frataxin family
HPY16_RS00540	COG0019	diaminopimelate decarboxylase activity
HPY16_RS00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY16_RS00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY16_RS00560	COG1011	Hydrolase
HPY16_RS00565	COG2199	diguanylate cyclase activity
HPY16_RS00565	COG3287	FIST C domain
HPY16_RS00565	COG2200	EAL domain
HPY16_RS00580	COG0561	phosphatase activity
HPY16_RS00585	COG2267	carboxylic ester hydrolase activity
HPY16_RS00590	COG1280	lysine exporter protein (LysE YggA)
HPY16_RS00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY16_RS00600	COG0783	Belongs to the Dps family
HPY16_RS00630	COG0742	ribosomal rna small subunit methyltransferase
HPY16_RS00635	COG0552	protein localization to endoplasmic reticulum
HPY16_RS00640	COG2884	Cell division ATP-binding protein ftsE
HPY16_RS00645	COG2177	Part of the ABC transporter FtsEX involved in
HPY16_RS00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY16_RS00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY16_RS00675	COG4206	TonB-dependent receptor
HPY16_RS00680	COG1404	Belongs to the peptidase S8 family
HPY16_RS00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY16_RS00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY16_RS00755	COG3300	MHYT domain
HPY16_RS00755	COG5001	Diguanylate cyclase
HPY16_RS00765	COG3852	Histidine kinase
HPY16_RS00775	COG0174	glutamine synthetase
HPY16_RS00795	COG1295	ribonuclease BN
HPY16_RS00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY16_RS00805	COG0456	acetyltransferase
HPY16_RS00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY16_RS00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY16_RS00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY16_RS00830	COG3031	protein transport across the cell outer membrane
HPY16_RS00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY16_RS00845	COG1459	type II secretion system
HPY16_RS00850	COG2165	general secretion pathway protein
HPY16_RS00855	COG2165	general secretion pathway protein
HPY16_RS00860	COG2165	general secretion pathway protein
HPY16_RS00865	COG4795	General secretion pathway protein
HPY16_RS00870	COG3156	type II secretion system protein K
HPY16_RS00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY16_RS00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY16_RS00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY16_RS00895	COG0494	nUDIX hydrolase
HPY16_RS00905	COG1040	competence protein
HPY16_RS00915	COG0596	Alpha beta hydrolase
HPY16_RS00925	COG2183	response to ionizing radiation
HPY16_RS00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY16_RS00935	COG0745	RESPONSE REGULATOR receiver
HPY16_RS00945	COG2233	PERMEase
HPY16_RS00950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY16_RS00955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY16_RS00960	COG1758	RNA polymerase activity
HPY16_RS00965	COG0194	GDP metabolic process
HPY16_RS00970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY16_RS00975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY16_RS00995	COG4232	protein-disulfide reductase activity
HPY16_RS01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY16_RS01015	COG1027	Aspartate ammonia-lyase
HPY16_RS01020	COG3706	GGDEF domain
HPY16_RS01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY16_RS01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY16_RS01040	COG2205	protein histidine kinase activity
HPY16_RS01045	COG0745	RESPONSE REGULATOR receiver
HPY16_RS01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY16_RS01060	COG0205	6-phosphofructokinase activity
HPY16_RS01065	COG1494	fructose-1,6-bisphosphatase
HPY16_RS01070	COG3074	FtsZ-dependent cytokinesis
HPY16_RS01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY16_RS01080	COG0460	homoserine dehydrogenase
HPY16_RS01080	COG0527	aspartate kinase activity
HPY16_RS01085	COG0626	cystathionine gamma-synthase activity
HPY16_RS01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY16_RS01095	COG0281	malic enzyme
HPY16_RS01100	COG0254	rRNA binding
HPY16_RS01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY16_RS01110	COG1609	Transcriptional regulator
HPY16_RS01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY16_RS01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY16_RS01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY16_RS01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY16_RS01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY16_RS01140	COG0534	Mate efflux family protein
HPY16_RS01145	COG0149	triose-phosphate isomerase activity
HPY16_RS01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY16_RS01175	COG0459	protein refolding
HPY16_RS01185	COG1509	lysine 2,3-aminomutase activity
HPY16_RS01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY16_RS01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY16_RS01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY16_RS01210	COG1053	succinate dehydrogenase
HPY16_RS01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY16_RS01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY16_RS01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY16_RS01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY16_RS01235	COG1045	serine acetyltransferase
HPY16_RS01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY16_RS01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY16_RS01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY16_RS01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY16_RS01265	COG0137	argininosuccinate synthase activity
HPY16_RS01270	COG0165	Argininosuccinate lyase
HPY16_RS01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_RS01285	COG0678	peroxiredoxin activity
HPY16_RS01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY16_RS01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY16_RS01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY16_RS01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY16_RS01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY16_RS01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY16_RS01350	COG0546	phosphoglycolate phosphatase activity
HPY16_RS01355	COG0180	Tryptophanyl-tRNA synthetase
HPY16_RS01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY16_RS01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY16_RS01390	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_RS01405	COG3954	Phosphoribulokinase
HPY16_RS01415	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY16_RS01425	COG0488	(ABC) transporter
HPY16_RS01430	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY16_RS01445	COG1047	Peptidyl-prolyl cis-trans
HPY16_RS01455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY16_RS01460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY16_RS01470	COG0557	exoribonuclease II activity
HPY16_RS01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY16_RS01480	COG0051	transcription antitermination factor activity, RNA binding
HPY16_RS01485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY16_RS01490	COG0088	Forms part of the polypeptide exit tunnel
HPY16_RS01495	COG0089	rRNA binding
HPY16_RS01500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY16_RS01505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY16_RS01510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY16_RS01515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY16_RS01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY16_RS01525	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY16_RS01530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY16_RS01535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY16_RS01540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY16_RS01545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY16_RS01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY16_RS01555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY16_RS01560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY16_RS01565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY16_RS01570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY16_RS01575	COG1841	ribosomal large subunit assembly
HPY16_RS01585	COG0201	protein transport
HPY16_RS01590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY16_RS01595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY16_RS01600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY16_RS01605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY16_RS01610	COG0202	RNA polymerase activity
HPY16_RS01615	COG0203	ribosomal protein L17
HPY16_RS01625	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY16_RS01630	COG3061	Opacity-associated protein A
HPY16_RS01630	COG3266	domain, Protein
HPY16_RS01635	COG0697	spore germination
HPY16_RS01640	COG2153	protein acetylation
HPY16_RS01645	COG0513	Belongs to the DEAD box helicase family
HPY16_RS01655	COG0737	Belongs to the 5'-nucleotidase family
HPY16_RS01660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY16_RS01660	COG1648	precorrin-2 dehydrogenase activity
HPY16_RS01665	COG0175	sulfate reduction
HPY16_RS01670	COG2895	sulfate adenylyltransferase (ATP) activity
HPY16_RS01675	COG0529	Catalyzes the synthesis of activated sulfate
HPY16_RS01695	COG1136	(ABC) transporter
HPY16_RS01710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY16_RS01715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_RS01720	COG0729	surface antigen
HPY16_RS01730	COG2105	PFAM AIG2 family protein
HPY16_RS01735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY16_RS01745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY16_RS01750	COG0163	prenyltransferase activity
HPY16_RS01760	COG1178	ABC-type Fe3 transport system permease component
HPY16_RS01765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY16_RS01770	COG3028	Belongs to the UPF0307 family
HPY16_RS01775	COG0312	modulator of DNA gyrase
HPY16_RS01780	COG2239	Acts as a magnesium transporter
HPY16_RS01785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS01790	COG1660	Displays ATPase and GTPase activities
HPY16_RS01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS01800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY16_RS01810	COG1137	ATPase activity
HPY16_RS01815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY16_RS01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY16_RS01830	COG0517	IMP dehydrogenase activity
HPY16_RS01840	COG1127	ABC transporter
HPY16_RS01845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY16_RS01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY16_RS01855	COG2854	intermembrane phospholipid transfer
HPY16_RS01865	COG5007	Belongs to the BolA IbaG family
HPY16_RS01870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY16_RS01880	COG0251	oxidation-reduction process
HPY16_RS01890	COG0540	Belongs to the ATCase OTCase family
HPY16_RS01900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY16_RS01910	COG0564	pseudouridine synthase activity
HPY16_RS01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY16_RS01920	COG0525	valine-tRNA ligase activity
HPY16_RS01925	COG2927	DNA polymerase III (CHI subunit)
HPY16_RS01930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY16_RS01935	COG0795	lipopolysaccharide-transporting ATPase activity
HPY16_RS01940	COG0795	lipopolysaccharide-transporting ATPase activity
HPY16_RS01955	COG3437	response regulator, receiver
HPY16_RS01995	COG0066	3-isopropylmalate dehydratase activity
HPY16_RS02000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY16_RS02005	COG0473	3-isopropylmalate dehydrogenase activity
HPY16_RS02025	COG0583	DNA-binding transcription factor activity
HPY16_RS02030	COG1022	Amp-dependent synthetase and ligase
HPY16_RS02035	COG0028	Belongs to the TPP enzyme family
HPY16_RS02040	COG0440	acetolactate synthase activity
HPY16_RS02045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY16_RS02050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY16_RS02055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY16_RS02065	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY16_RS02070	COG3079	Belongs to the UPF0149 family
HPY16_RS02075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_RS02080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_RS02090	COG0354	folic acid binding
HPY16_RS02095	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY16_RS02105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY16_RS02110	COG1595	DNA-templated transcription, initiation
HPY16_RS02125	COG3086	response to oxidative stress
HPY16_RS02130	COG0481	GTPase activity
HPY16_RS02140	COG0571	ribonuclease III activity
HPY16_RS02145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY16_RS02150	COG1381	Involved in DNA repair and RecF pathway recombination
HPY16_RS02155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY16_RS02185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY16_RS02190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY16_RS02195	COG3956	TIGRFAM MazG family protein
HPY16_RS02200	COG0504	CTP synthase activity
HPY16_RS02205	COG0148	phosphopyruvate hydratase activity
HPY16_RS02225	COG4991	sh3 domain protein
HPY16_RS02230	COG0306	phosphate transporter
HPY16_RS02235	COG1392	Phosphate transport regulator
HPY16_RS02240	COG3025	triphosphatase activity
HPY16_RS02250	COG0840	transmembrane signaling receptor activity
HPY16_RS02255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY16_RS02260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY16_RS02260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY16_RS02265	COG1538	Outer membrane efflux protein
HPY16_RS02270	COG0494	nUDIX hydrolase
HPY16_RS02275	COG3151	Protein conserved in bacteria
HPY16_RS02285	COG3150	esterase
HPY16_RS02290	COG0187	DNA topoisomerase II activity
HPY16_RS02295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY16_RS02305	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY16_RS02310	COG0237	dephospho-CoA kinase activity
HPY16_RS02320	COG1459	type II secretion system
HPY16_RS02325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY16_RS02330	COG4969	Belongs to the N-Me-Phe pilin family
HPY16_RS02335	COG0157	Belongs to the NadC ModD family
HPY16_RS02350	COG0716	FMN binding
HPY16_RS02355	COG4974	Belongs to the 'phage' integrase family
HPY16_RS02360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY16_RS02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY16_RS02370	COG2186	Transcriptional regulator
HPY16_RS02375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY16_RS02380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY16_RS02385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_RS02400	COG3116	cell division
HPY16_RS02405	COG0768	penicillin binding
HPY16_RS02410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY16_RS02415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY16_RS02425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY16_RS02430	COG0772	Belongs to the SEDS family
HPY16_RS02435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY16_RS02440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY16_RS02450	COG0849	cell division
HPY16_RS02455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY16_RS02460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY16_RS02470	COG0653	protein targeting
HPY16_RS02475	COG0494	nUDIX hydrolase
HPY16_RS02480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY16_RS02490	COG0505	Belongs to the CarA family
HPY16_RS02495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY16_RS02510	COG0730	response to heat
HPY16_RS02515	COG0583	DNA-binding transcription factor activity
HPY16_RS02520	COG2860	membrane
HPY16_RS02525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY16_RS02535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY16_RS02545	COG0493	'glutamate synthase
HPY16_RS02550	COG0070	glutamate synthase
HPY16_RS02550	COG0067	glutamate synthase
HPY16_RS02550	COG0069	glutamate synthase activity
HPY16_RS02560	COG0067	glutamate synthase
HPY16_RS02560	COG0069	glutamate synthase activity
HPY16_RS02560	COG0070	glutamate synthase
HPY16_RS02565	COG1242	4 iron, 4 sulfur cluster binding
HPY16_RS02570	COG2203	Gaf domain
HPY16_RS02570	COG3706	GGDEF domain
HPY16_RS02570	COG4251	negative regulation of phosphorylation
HPY16_RS02570	COG5001	Diguanylate cyclase
HPY16_RS02575	COG0784	Response regulator, receiver
HPY16_RS02575	COG5002	protein histidine kinase activity
HPY16_RS02575	COG2198	Histidine kinase
HPY16_RS02580	COG0745	RESPONSE REGULATOR receiver
HPY16_RS02590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY16_RS02610	COG0083	homoserine kinase activity
HPY16_RS02615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY16_RS02620	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY16_RS02625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY16_RS02630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY16_RS02645	COG1115	amino acid carrier protein
HPY16_RS02650	COG3022	response to hydroperoxide
HPY16_RS02660	COG0084	hydrolase, TatD family'
HPY16_RS02665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY16_RS02675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY16_RS02680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY16_RS02685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY16_RS02690	COG0813	purine-nucleoside phosphorylase activity
HPY16_RS02700	COG0560	Phosphoserine phosphatase
HPY16_RS02710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY16_RS02715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY16_RS02720	COG1022	Amp-dependent synthetase and ligase
HPY16_RS02735	COG3250	beta-galactosidase activity
HPY16_RS02740	COG1609	Transcriptional regulator
HPY16_RS02745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_RS02760	COG0569	domain protein
HPY16_RS02760	COG0189	ligase activity
HPY16_RS02765	COG0456	acetyltransferase
HPY16_RS02775	COG2171	N-acyltransferase activity
HPY16_RS02780	COG3141	response to X-ray
HPY16_RS02795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY16_RS02800	COG1074	ATP-dependent DNA helicase activity
HPY16_RS02805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY16_RS02815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY16_RS02815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY16_RS02825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY16_RS02830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY16_RS02835	COG2166	iron-sulfur cluster assembly
HPY16_RS02840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY16_RS02845	COG0693	protein deglycase activity
HPY16_RS02850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY16_RS02865	COG1595	DNA-templated transcription, initiation
HPY16_RS02875	COG2211	Major facilitator Superfamily
HPY16_RS02880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY16_RS02890	COG2813	Specifically methylates the guanine in position
HPY16_RS02895	COG0271	Belongs to the BolA IbaG family
HPY16_RS02900	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_RS02905	COG1805	sodium ion transport
HPY16_RS02910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_RS02915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_RS02920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY16_RS02925	COG2871	sodium ion transport
HPY16_RS02930	COG1477	protein flavinylation
HPY16_RS02950	COG3706	GGDEF domain
HPY16_RS02955	COG0733	neurotransmitter:sodium symporter activity
HPY16_RS02965	COG0189	ligase activity
HPY16_RS02970	COG0189	ligase activity
HPY16_RS02970	COG4067	protein conserved in archaea
HPY16_RS02975	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY16_RS02980	COG2252	PERMEase
HPY16_RS02985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY16_RS03000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY16_RS03005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY16_RS03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY16_RS03015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_RS03015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_RS03030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY16_RS03035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY16_RS03040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY16_RS03045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY16_RS03055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY16_RS03060	COG0024	Methionine aminopeptidase
HPY16_RS03065	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY16_RS03070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY16_RS03075	COG0528	UMP kinase activity
HPY16_RS03080	COG0233	cytoplasmic translational termination
HPY16_RS03085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY16_RS03090	COG0575	Belongs to the CDS family
HPY16_RS03095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY16_RS03100	COG0750	zinc metalloprotease
HPY16_RS03110	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY16_RS03115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_RS03120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY16_RS03125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_RS03130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_RS03135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY16_RS03140	COG0587	DNA-directed DNA polymerase activity
HPY16_RS03145	COG0825	malonyl-CoA metabolic process
HPY16_RS03155	COG0037	tRNA processing
HPY16_RS03165	COG3479	Phenolic acid decarboxylase
HPY16_RS03170	COG0347	Belongs to the P(II) protein family
HPY16_RS03175	COG3021	interspecies interaction between organisms
HPY16_RS03180	COG0741	lytic transglycosylase activity
HPY16_RS03180	COG1388	LysM domain
HPY16_RS03185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY16_RS03190	COG2226	methyltransferase
HPY16_RS03195	COG0328	RNA-DNA hybrid ribonuclease activity
HPY16_RS03210	COG1960	acyl-CoA dehydrogenase activity
HPY16_RS03215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY16_RS03220	COG0121	glutamine amidotransferase
HPY16_RS03225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY16_RS03230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY16_RS03235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY16_RS03240	COG3706	GGDEF domain
HPY16_RS03245	COG1187	pseudouridine synthase activity
HPY16_RS03250	COG2840	Smr protein MutS2
HPY16_RS03265	COG3735	TraB family
HPY16_RS03280	COG2608	mercury ion transmembrane transporter activity
HPY16_RS03280	COG2217	Heavy metal translocating P-type atpase
HPY16_RS03285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY16_RS03300	COG4774	siderophore transport
HPY16_RS03300	COG1629	transport
HPY16_RS03305	COG2375	cellular response to nickel ion
HPY16_RS03310	COG3433	isochorismatase activity
HPY16_RS03310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY16_RS03310	COG2226	methyltransferase
HPY16_RS03345	COG0835	chemotaxis
HPY16_RS03345	COG0784	Response regulator, receiver
HPY16_RS03350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY16_RS03355	COG1815	bacterial-type flagellum-dependent cell motility
HPY16_RS03370	COG1749	Flagellar hook protein flgE
HPY16_RS03375	COG4787	bacterial-type flagellum-dependent cell motility
HPY16_RS03385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY16_RS03390	COG1706	bacterial-type flagellum-dependent cell motility
HPY16_RS03395	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY16_RS03395	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY16_RS03410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_RS03415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_RS03500	COG0012	GTP binding
HPY16_RS03505	COG0193	aminoacyl-tRNA hydrolase activity
HPY16_RS03510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY16_RS03515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY16_RS03520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY16_RS03525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY16_RS03530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY16_RS03535	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY16_RS03545	COG2912	Transglutaminase-like superfamily
HPY16_RS03550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY16_RS03555	COG0737	Belongs to the 5'-nucleotidase family
HPY16_RS03560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY16_RS03565	COG2233	PERMEase
HPY16_RS03585	COG1393	Belongs to the ArsC family
HPY16_RS03590	COG4783	chaperone-mediated protein folding
HPY16_RS03610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY16_RS03625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY16_RS03635	COG1876	peptidase activity
HPY16_RS03645	COG1393	Belongs to the ArsC family
HPY16_RS03665	COG2837	iron assimilation
HPY16_RS03670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_RS03675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_RS03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY16_RS03685	COG1334	flagellar protein FlaG
HPY16_RS03690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY16_RS03700	COG1516	flagellar protein fliS
HPY16_RS03710	COG4191	Histidine kinase
HPY16_RS03720	COG1677	Flagellar hook-basal body complex protein FliE
HPY16_RS03730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY16_RS03735	COG1317	bacterial-type flagellum organization
HPY16_RS03760	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY16_RS03785	COG1987	bacterial-type flagellum assembly
HPY16_RS03790	COG1684	flagellar biosynthetic protein fliR
HPY16_RS03795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPY16_RS03800	COG2840	Smr protein MutS2
HPY16_RS03805	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY16_RS03810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY16_RS03815	COG2860	membrane
HPY16_RS03820	COG3101	peptidyl-lysine hydroxylation
HPY16_RS03830	COG0431	NADPH-dependent FMN reductase
HPY16_RS03840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY16_RS03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY16_RS03850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY16_RS03855	COG0735	belongs to the Fur family
HPY16_RS03865	COG0583	DNA-binding transcription factor activity
HPY16_RS03875	COG1346	cytolysis
HPY16_RS03890	COG0596	Alpha beta hydrolase
HPY16_RS03895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY16_RS03900	COG0033	Phosphoglucomutase
HPY16_RS03910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY16_RS03915	COG0372	Belongs to the citrate synthase family
HPY16_RS03920	COG2009	succinate dehydrogenase
HPY16_RS03925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY16_RS03930	COG1053	succinate dehydrogenase
HPY16_RS03940	COG0567	Dehydrogenase, E1 component
HPY16_RS03945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY16_RS03950	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY16_RS03960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY16_RS03965	COG1121	(ABC) transporter
HPY16_RS03970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY16_RS03975	COG4977	sequence-specific DNA binding
HPY16_RS03980	COG1918	ferrous iron import across plasma membrane
HPY16_RS04000	COG0018	arginyl-trna synthetase
HPY16_RS04010	COG1025	Belongs to the peptidase M16 family
HPY16_RS04015	COG2062	phosphohistidine phosphatase, SixA
HPY16_RS04045	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY16_RS04050	COG0784	Response regulator, receiver
HPY16_RS04050	COG2198	Histidine kinase
HPY16_RS04050	COG0643	Histidine kinase
HPY16_RS04055	COG2201	protein-glutamate methylesterase activity
HPY16_RS04060	COG1192	Involved in chromosome partitioning
HPY16_RS04070	COG0835	chemotaxis
HPY16_RS04080	COG4133	protoheme IX ABC transporter activity
HPY16_RS04085	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY16_RS04090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY16_RS04100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY16_RS04105	COG1138	Cytochrome C-type biogenesis protein
HPY16_RS04110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY16_RS04115	COG3088	subunit of a heme lyase
HPY16_RS04115	COG4235	cytochrome complex assembly
HPY16_RS04125	COG2853	Lipoprotein
HPY16_RS04145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY16_RS04150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY16_RS04155	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY16_RS04170	COG3083	sulfuric ester hydrolase activity
HPY16_RS04175	COG3082	Protein of unknown function (DUF1414)
HPY16_RS04180	COG3081	Nucleoid-associated protein
HPY16_RS04190	COG1757	Na H antiporter
HPY16_RS04195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY16_RS04200	COG2095	MarC family integral membrane protein
HPY16_RS04205	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_RS04205	COG1454	alcohol dehydrogenase
HPY16_RS04215	COG0659	secondary active sulfate transmembrane transporter activity
HPY16_RS04220	COG1530	ribonuclease E activity
HPY16_RS04225	COG0564	pseudouridine synthase activity
HPY16_RS04230	COG0424	maF-like protein
HPY16_RS04235	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY16_RS04240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY16_RS04245	COG0416	fatty acid biosynthetic process
HPY16_RS04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY16_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_RS04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY16_RS04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY16_RS04275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY16_RS04280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY16_RS04285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY16_RS04295	COG0084	hydrolase, TatD family'
HPY16_RS04300	COG1263	PTS System
HPY16_RS04300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_RS04315	COG0733	neurotransmitter:sodium symporter activity
HPY16_RS04330	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY16_RS04340	COG1940	carbohydrate kinase activity
HPY16_RS04345	COG0784	Response regulator, receiver
HPY16_RS04345	COG0835	chemotaxis
HPY16_RS04360	COG2226	methyltransferase
HPY16_RS04370	COG0676	glucose-6-phosphate 1-epimerase activity
HPY16_RS04375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY16_RS04380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_RS04390	COG3139	Protein of unknown function (DUF1315)
HPY16_RS04395	COG0252	asparaginase activity
HPY16_RS04400	COG0616	signal peptide processing
HPY16_RS04405	COG1902	pentaerythritol trinitrate reductase activity
HPY16_RS04405	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY16_RS04410	COG0788	formyltetrahydrofolate deformylase activity
HPY16_RS04420	COG1199	ATP-dependent helicase activity
HPY16_RS04425	COG1214	PFAM Peptidase M22, glycoprotease
HPY16_RS04440	COG0596	Alpha beta hydrolase
HPY16_RS04445	COG0318	PFAM AMP-dependent synthetase and ligase
HPY16_RS04450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY16_RS04465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY16_RS04470	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY16_RS04475	COG0436	Aminotransferase
HPY16_RS04480	COG1169	isochorismate synthase
HPY16_RS04485	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY16_RS04490	COG0596	Alpha beta hydrolase
HPY16_RS04510	COG3135	benzoate transporter
HPY16_RS04535	COG3015	lipoprotein NlpE involved in copper resistance
HPY16_RS04540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY16_RS04545	COG2894	cell division
HPY16_RS04550	COG0850	regulation of cytokinetic process
HPY16_RS04555	COG3100	YcgL domain-containing protein
HPY16_RS04560	COG2951	lytic endotransglycosylase activity
HPY16_RS04570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY16_RS04575	COG3005	denitrification pathway
HPY16_RS04580	COG0243	molybdopterin cofactor binding
HPY16_RS04595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_RS04610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY16_RS04660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY16_RS04665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY16_RS04670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY16_RS04675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY16_RS04685	COG4191	Histidine kinase
HPY16_RS04695	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY16_RS04705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY16_RS04710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY16_RS04715	COG0776	regulation of translation
HPY16_RS04720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY16_RS04725	COG1555	photosystem II stabilization
HPY16_RS04730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY16_RS04735	COG0539	negative regulation of cytoplasmic translation
HPY16_RS04740	COG0776	regulation of translation
HPY16_RS04745	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY16_RS04750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY16_RS04770	COG0583	DNA-binding transcription factor activity
HPY16_RS04780	COG0686	Belongs to the AlaDH PNT family
HPY16_RS04790	COG1674	ftsk spoiiie
HPY16_RS04795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY16_RS04800	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY16_RS04805	COG2186	Transcriptional regulator
HPY16_RS04820	COG0537	adenosine 5'-monophosphoramidase activity
HPY16_RS04845	COG3150	esterase
HPY16_RS04850	COG1252	NADH dehydrogenase
HPY16_RS04875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY16_RS04885	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY16_RS04890	COG1136	(ABC) transporter
HPY16_RS04895	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY16_RS04905	COG2333	competence protein COMEC
HPY16_RS04905	COG0658	competence protein
HPY16_RS04910	COG1132	(ABC) transporter
HPY16_RS04915	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY16_RS04920	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY16_RS04925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY16_RS04930	COG2719	SpoVR family
HPY16_RS04935	COG2718	Belongs to the UPF0229 family
HPY16_RS04940	COG2766	serine protein kinase
HPY16_RS04945	COG3013	Belongs to the UPF0304 family
HPY16_RS04955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY16_RS04960	COG0840	transmembrane signaling receptor activity
HPY16_RS04970	COG1882	Formate acetyltransferase
HPY16_RS04995	COG4160	amino acid transport
HPY16_RS05000	COG0708	Exodeoxyribonuclease III
HPY16_RS05010	COG3923	Primosomal replication protein n
HPY16_RS05015	COG0730	response to heat
HPY16_RS05020	COG1199	ATP-dependent helicase activity
HPY16_RS05030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY16_RS05035	COG3012	SEC-C Motif Domain Protein
HPY16_RS05040	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY16_RS05045	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY16_RS05050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY16_RS05055	COG0215	cysteine-tRNA ligase activity
HPY16_RS05060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY16_RS05065	COG0632	four-way junction helicase activity
HPY16_RS05075	COG1271	oxidase subunit
HPY16_RS05080	COG1294	oxidase, subunit
HPY16_RS05085	COG4890	Cyd operon protein YbgT
HPY16_RS05090	COG3790	cyd operon protein YbgE
HPY16_RS05095	COG0824	Thioesterase
HPY16_RS05100	COG0811	peptide transport
HPY16_RS05115	COG0823	Involved in the tonB-independent uptake of proteins
HPY16_RS05120	COG2885	chlorophyll binding
HPY16_RS05130	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY16_RS05140	COG5002	protein histidine kinase activity
HPY16_RS05140	COG0784	Response regulator, receiver
HPY16_RS05150	COG1482	cell wall glycoprotein biosynthetic process
HPY16_RS05155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_RS05155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_RS05155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS05160	COG2207	Transcriptional regulator
HPY16_RS05170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_RS05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_RS05180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_RS05195	COG4628	conserved protein (DUF2132)
HPY16_RS05205	COG0415	Belongs to the DNA photolyase family
HPY16_RS05240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_RS05250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY16_RS05250	COG3008	intermembrane lipid transfer
HPY16_RS05255	COG2995	paraquat-inducible protein a
HPY16_RS05260	COG0668	transmembrane transport
HPY16_RS05280	COG1309	transcriptional regulator
HPY16_RS05285	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_RS05315	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY16_RS05320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY16_RS05325	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY16_RS05330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY16_RS05345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY16_RS05350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY16_RS05355	COG0297	glycogen (starch) synthase activity
HPY16_RS05375	COG3070	regulator of competence-specific genes
HPY16_RS05380	COG1609	Transcriptional regulator
HPY16_RS05385	COG3381	protein complex oligomerization
HPY16_RS05390	COG0745	RESPONSE REGULATOR receiver
HPY16_RS05395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY16_RS05400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY16_RS05405	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY16_RS05410	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY16_RS05430	COG1032	radical SAM domain protein
HPY16_RS05435	COG5001	Diguanylate cyclase
HPY16_RS05440	COG0612	Peptidase, M16
HPY16_RS05455	COG0583	DNA-binding transcription factor activity
HPY16_RS05460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY16_RS05470	COG2350	Protein conserved in bacteria
HPY16_RS05475	COG1607	acyl-coa hydrolase
HPY16_RS05490	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY16_RS05495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY16_RS05505	COG2116	formate transmembrane transporter activity
HPY16_RS05510	COG4459	periplasmic nitrate reductase
HPY16_RS05515	COG3005	denitrification pathway
HPY16_RS05520	COG0243	molybdopterin cofactor binding
HPY16_RS05540	COG1227	inorganic diphosphatase activity
HPY16_RS05560	COG4172	Belongs to the ABC transporter superfamily
HPY16_RS05575	COG4168	peptide transport system, permease
HPY16_RS05585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY16_RS05590	COG1842	Phage shock protein A
HPY16_RS05605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_RS05620	COG2818	Glycosylase
HPY16_RS05625	COG0626	cystathionine gamma-synthase activity
HPY16_RS05635	COG0733	neurotransmitter:sodium symporter activity
HPY16_RS05640	COG0564	pseudouridine synthase activity
HPY16_RS05645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY16_RS05650	COG4136	ATPase activity
HPY16_RS05655	COG4135	transport system, permease component
HPY16_RS05660	COG4134	Bacterial extracellular solute-binding protein
HPY16_RS05670	COG3313	Fe-S protein
HPY16_RS05680	COG0814	amino acid
HPY16_RS05690	COG2239	Acts as a magnesium transporter
HPY16_RS05695	COG2205	protein histidine kinase activity
HPY16_RS05695	COG0784	Response regulator, receiver
HPY16_RS05710	COG4934	collagen metabolic process
HPY16_RS05745	COG0840	transmembrane signaling receptor activity
HPY16_RS05755	COG2203	Gaf domain
HPY16_RS05755	COG3706	GGDEF domain
HPY16_RS05755	COG4251	negative regulation of phosphorylation
HPY16_RS05755	COG5001	Diguanylate cyclase
HPY16_RS05760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY16_RS05765	COG5002	protein histidine kinase activity
HPY16_RS05780	COG1061	Type III restriction enzyme res subunit
HPY16_RS05785	COG1187	pseudouridine synthase activity
HPY16_RS05790	COG2814	Major facilitator Superfamily
HPY16_RS05800	COG0702	epimerase
HPY16_RS05805	COG0534	Mate efflux family protein
HPY16_RS05810	COG4181	ATPase activity
HPY16_RS05825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY16_RS05835	COG1748	Saccharopine dehydrogenase
HPY16_RS05850	COG1538	Outer membrane efflux protein
HPY16_RS05870	COG0583	DNA-binding transcription factor activity
HPY16_RS05880	COG1451	nucleotide metabolic process
HPY16_RS05895	COG3063	Type IV pilus biogenesis stability protein PilW
HPY16_RS05900	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY16_RS05920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_RS05935	COG3290	protein histidine kinase activity
HPY16_RS05940	COG4565	transcriptional regulatory protein
HPY16_RS05950	COG0784	Response regulator, receiver
HPY16_RS05950	COG0835	chemotaxis
HPY16_RS06000	COG1085	galactose-1-phosphate uridylyltransferase
HPY16_RS06005	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY16_RS06010	COG2017	converts alpha-aldose to the beta-anomer
HPY16_RS06025	COG3527	Alpha-acetolactate decarboxylase
HPY16_RS06045	COG0753	catalase activity
HPY16_RS06065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY16_RS06115	COG1271	oxidase subunit
HPY16_RS06120	COG1294	oxidase, subunit
HPY16_RS06125	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY16_RS06125	COG1136	(ABC) transporter
HPY16_RS06130	COG0577	efflux transmembrane transporter activity
HPY16_RS06130	COG1136	(ABC) transporter
HPY16_RS06135	COG0577	efflux transmembrane transporter activity
HPY16_RS06135	COG1136	(ABC) transporter
HPY16_RS06185	COG2816	NAD+ diphosphatase activity
HPY16_RS06190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY16_RS06205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY16_RS06215	COG2723	6-phospho-beta-galactosidase activity
HPY16_RS06220	COG1609	Transcriptional regulator
HPY16_RS06225	COG0251	oxidation-reduction process
HPY16_RS06230	COG2731	YhcH YjgK YiaL family protein
HPY16_RS06235	COG0584	glycerophosphoryl diester phosphodiesterase
HPY16_RS06240	COG1349	DNA-binding transcription factor activity
HPY16_RS06245	COG3842	ATPase activity
HPY16_RS06250	COG0395	ABC-type sugar transport system, permease component
HPY16_RS06255	COG1175	transmembrane transport
HPY16_RS06270	COG0811	peptide transport
HPY16_RS06275	COG0811	peptide transport
HPY16_RS06280	COG0848	biopolymer transport protein
HPY16_RS06285	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY16_RS06295	COG1793	dna ligase
HPY16_RS06305	COG0534	Mate efflux family protein
HPY16_RS06315	COG3001	Fructosamine kinase
HPY16_RS06325	COG0791	NLP P60 protein
HPY16_RS06330	COG0840	transmembrane signaling receptor activity
HPY16_RS06345	COG1940	carbohydrate kinase activity
HPY16_RS06360	COG0746	molybdenum cofactor guanylyltransferase activity
HPY16_RS06365	COG3842	ATPase activity
HPY16_RS06370	COG4662	Binding-protein-dependent transport system inner membrane component
HPY16_RS06380	COG2204	response regulator
HPY16_RS06385	COG3852	Histidine kinase
HPY16_RS06390	COG0488	(ABC) transporter
HPY16_RS06395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY16_RS06425	COG3383	formate dehydrogenase (NAD+) activity
HPY16_RS06425	COG0243	molybdopterin cofactor binding
HPY16_RS06430	COG0437	4 iron, 4 sulfur cluster binding
HPY16_RS06445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY16_RS06450	COG1666	GTP binding
HPY16_RS06455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY16_RS06470	COG2996	Protein conserved in bacteria
HPY16_RS06480	COG3008	intermembrane lipid transfer
HPY16_RS06485	COG2995	paraquat-inducible protein a
HPY16_RS06490	COG1132	(ABC) transporter
HPY16_RS06495	COG1956	GAF domain-containing protein
HPY16_RS06500	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY16_RS06515	COG0308	aminopeptidase N
HPY16_RS06530	COG0167	dihydroorotate dehydrogenase activity
HPY16_RS06540	COG0116	Belongs to the methyltransferase superfamily
HPY16_RS06540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY16_RS06565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY16_RS06570	COG1067	ATP-dependent peptidase activity
HPY16_RS06575	COG3120	sequence-specific DNA binding
HPY16_RS06590	COG3064	Membrane
HPY16_RS06590	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY16_RS06590	COG1073	alpha beta
HPY16_RS06595	COG2994	toxin metabolic process
HPY16_RS06620	COG2205	protein histidine kinase activity
HPY16_RS06620	COG0784	Response regulator, receiver
HPY16_RS06635	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY16_RS06650	COG2010	Cytochrome c
HPY16_RS06660	COG2217	Heavy metal translocating P-type atpase
HPY16_RS06675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY16_RS06680	COG0589	response to stress
HPY16_RS06685	COG0037	tRNA processing
HPY16_RS06705	COG3842	ATPase activity
HPY16_RS06715	COG1177	transmembrane transport
HPY16_RS06725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY16_RS06740	COG1115	amino acid carrier protein
HPY16_RS06745	COG1280	lysine exporter protein (LysE YggA)
HPY16_RS06775	COG3501	Rhs element vgr protein
HPY16_RS06785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY16_RS06805	COG0513	Belongs to the DEAD box helicase family
HPY16_RS06810	COG2076	Multidrug Resistance protein
HPY16_RS06815	COG0415	Belongs to the DNA photolyase family
HPY16_RS06820	COG0477	Major facilitator Superfamily
HPY16_RS06825	COG0583	DNA-binding transcription factor activity
HPY16_RS06835	COG0402	S-adenosylhomocysteine deaminase activity
HPY16_RS06840	COG0095	Lipoate-protein ligase
HPY16_RS06845	COG0443	Heat shock 70 kDa protein
HPY16_RS06855	COG1643	Atp-dependent helicase
HPY16_RS06885	COG0443	Heat shock 70 kDa protein
HPY16_RS06890	COG0443	Heat shock 70 kDa protein
HPY16_RS06895	COG3706	GGDEF domain
HPY16_RS06925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY16_RS06930	COG0602	queuosine metabolic process
HPY16_RS06935	COG0561	phosphatase activity
HPY16_RS06945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_RS06950	COG4597	amino acid ABC transporter
HPY16_RS06955	COG0765	amino acid transport
HPY16_RS06960	COG1126	abc transporter atp-binding protein
HPY16_RS06965	COG0670	Belongs to the BI1 family
HPY16_RS06970	COG2920	part of a sulfur-relay system
HPY16_RS06975	COG1254	Belongs to the acylphosphatase family
HPY16_RS06980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY16_RS06985	COG3706	GGDEF domain
HPY16_RS07000	COG3437	response regulator, receiver
HPY16_RS07005	COG0625	glutathione transferase activity
HPY16_RS07015	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY16_RS07025	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY16_RS07055	COG0372	Belongs to the citrate synthase family
HPY16_RS07060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY16_RS07085	COG0583	DNA-binding transcription factor activity
HPY16_RS07090	COG4771	TonB-dependent receptor
HPY16_RS07115	COG1129	ABC transporter
HPY16_RS07140	COG0745	RESPONSE REGULATOR receiver
HPY16_RS07145	COG5002	protein histidine kinase activity
HPY16_RS07150	COG3713	MltA-interacting MipA family protein
HPY16_RS07155	COG2990	Protein conserved in bacteria
HPY16_RS07165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_RS07165	COG4191	Histidine kinase
HPY16_RS07170	COG0471	metal ion transport
HPY16_RS07180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY16_RS07195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS07205	COG3768	UPF0283 membrane protein
HPY16_RS07210	COG3106	COG3106 Predicted ATPase
HPY16_RS07230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY16_RS07235	COG0494	nUDIX hydrolase
HPY16_RS07240	COG0814	amino acid
HPY16_RS07245	COG1760	l-serine dehydratase
HPY16_RS07250	COG0720	synthase
HPY16_RS07255	COG0840	transmembrane signaling receptor activity
HPY16_RS07260	COG0017	Asparaginyl-tRNA synthetase
HPY16_RS07265	COG0351	phosphomethylpyrimidine kinase
HPY16_RS07265	COG0352	thiamine-phosphate diphosphorylase activity
HPY16_RS07270	COG3437	response regulator, receiver
HPY16_RS07270	COG2770	Histidine kinase
HPY16_RS07275	COG1448	Aminotransferase
HPY16_RS07290	COG0840	transmembrane signaling receptor activity
HPY16_RS07295	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY16_RS07300	COG2943	transferase activity, transferring hexosyl groups
HPY16_RS07305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY16_RS07310	COG1846	Transcriptional regulator
HPY16_RS07335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY16_RS07350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY16_RS07355	COG3108	Peptidase M15
HPY16_RS07385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY16_RS07395	COG2814	Major facilitator Superfamily
HPY16_RS07415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY16_RS07420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY16_RS07425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY16_RS07455	COG0840	transmembrane signaling receptor activity
HPY16_RS07470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY16_RS07475	COG4139	cobalamin transport
HPY16_RS07480	COG2988	succinylglutamate desuccinylase activity
HPY16_RS07500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY16_RS07505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_RS07515	COG2925	Exonuclease
HPY16_RS07520	COG1380	Effector of murein hydrolase LrgA
HPY16_RS07525	COG1346	cytolysis
HPY16_RS07555	COG0776	regulation of translation
HPY16_RS07560	COG0072	phenylalanine-tRNA ligase activity
HPY16_RS07560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_RS07565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY16_RS07605	COG0322	excinuclease ABC activity
HPY16_RS07610	COG2197	response regulator
HPY16_RS07615	COG0417	DNA replication proofreading
HPY16_RS07620	COG5001	Diguanylate cyclase
HPY16_RS07630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY16_RS07635	COG3099	Belongs to the UPF0263 family
HPY16_RS07650	COG1228	amidohydrolase
HPY16_RS07655	COG0010	Belongs to the arginase family
HPY16_RS07660	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY16_RS07665	COG2986	histidine ammonia-lyase
HPY16_RS07685	COG0247	lactate metabolic process
HPY16_RS07685	COG0277	FAD linked oxidase domain protein
HPY16_RS07700	COG2885	chlorophyll binding
HPY16_RS07720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY16_RS07730	COG0281	malic enzyme
HPY16_RS07740	COG2949	membrane
HPY16_RS07745	COG3706	GGDEF domain
HPY16_RS07750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY16_RS07760	COG0492	ferredoxin-NADP+ reductase activity
HPY16_RS07765	COG4988	ABC transporter
HPY16_RS07770	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY16_RS07775	COG1187	pseudouridine synthase activity
HPY16_RS07780	COG0009	L-threonylcarbamoyladenylate synthase
HPY16_RS07785	COG0613	PHP domain protein
HPY16_RS07795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY16_RS07800	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY16_RS07805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY16_RS07810	COG0135	phosphoribosylanthranilate isomerase activity
HPY16_RS07810	COG0134	indole-3-glycerol-phosphate synthase activity
HPY16_RS07815	COG0133	tryptophan synthase activity
HPY16_RS07820	COG0159	tryptophan synthase activity
HPY16_RS07830	COG1435	thymidine kinase activity
HPY16_RS07835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY16_RS07840	COG1801	Protein of unknown function DUF72
HPY16_RS07845	COG4106	trans-aconitate 2-methyltransferase activity
HPY16_RS07850	COG0500	methyltransferase
HPY16_RS07855	COG0189	ligase activity
HPY16_RS07855	COG4067	protein conserved in archaea
HPY16_RS07870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY16_RS07880	COG3852	Histidine kinase
HPY16_RS07895	COG3070	regulator of competence-specific genes
HPY16_RS07905	COG2431	L-lysine efflux transmembrane transporter activity
HPY16_RS07915	COG0076	glutamate decarboxylase activity
HPY16_RS07920	COG1737	Transcriptional regulator
HPY16_RS07925	COG1454	alcohol dehydrogenase
HPY16_RS07925	COG1012	belongs to the aldehyde dehydrogenase family
HPY16_RS07930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY16_RS07935	COG3273	potassium ion transport
HPY16_RS07935	COG2985	domain, Protein
HPY16_RS07940	COG0542	response to heat
HPY16_RS07945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY16_RS07950	COG1278	Cold shock
HPY16_RS07960	COG1187	pseudouridine synthase activity
HPY16_RS07965	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY16_RS07965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY16_RS07970	COG0107	imidazoleglycerol-phosphate synthase activity
HPY16_RS07975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY16_RS07980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY16_RS07985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY16_RS07985	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY16_RS07990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY16_RS07995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY16_RS08000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY16_RS08005	COG1757	Na H antiporter
HPY16_RS08010	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY16_RS08015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_RS08020	COG0482	sulfurtransferase activity
HPY16_RS08025	COG2915	High frequency lysogenization protein hflD homolog
HPY16_RS08030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY16_RS08040	COG2268	Band 7 protein
HPY16_RS08050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY16_RS08065	COG0300	oxidoreductase activity
HPY16_RS08075	COG0501	Belongs to the peptidase M48B family
HPY16_RS08085	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY16_RS08090	COG2226	methyltransferase
HPY16_RS08095	COG0156	8-amino-7-oxononanoate synthase activity
HPY16_RS08100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY16_RS08105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY16_RS08110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY16_RS08115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY16_RS08120	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY16_RS08125	COG0653	protein targeting
HPY16_RS08130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY16_RS08135	COG3706	GGDEF domain
HPY16_RS08145	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY16_RS08155	COG4628	conserved protein (DUF2132)
HPY16_RS08160	COG3092	negative regulation of chromosome organization
HPY16_RS08165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY16_RS08170	COG0280	phosphate acetyltransferase
HPY16_RS08170	COG0857	belongs to the CobB CobQ family
HPY16_RS08175	COG0435	Glutathione S-transferase
HPY16_RS08180	COG4608	Belongs to the ABC transporter superfamily
HPY16_RS08185	COG0444	Belongs to the ABC transporter superfamily
HPY16_RS08190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_RS08195	COG0601	transmembrane transport
HPY16_RS08215	COG2204	response regulator
HPY16_RS08220	COG3300	MHYT domain
HPY16_RS08220	COG5001	Diguanylate cyclase
HPY16_RS08225	COG4191	Histidine kinase
HPY16_RS08230	COG5002	protein histidine kinase activity
HPY16_RS08240	COG2201	protein-glutamate methylesterase activity
HPY16_RS08255	COG0009	L-threonylcarbamoyladenylate synthase
HPY16_RS08270	COG1881	PFAM PEBP family protein
HPY16_RS08295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY16_RS08300	COG0640	Transcriptional regulator
HPY16_RS08310	COG3706	GGDEF domain
HPY16_RS08330	COG1946	Acyl-CoA thioesterase
HPY16_RS08335	COG1522	sequence-specific DNA binding
HPY16_RS08345	COG0616	signal peptide processing
HPY16_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_RS08355	COG2983	Belongs to the UPF0260 family
HPY16_RS08365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY16_RS08370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY16_RS08375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY16_RS08380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY16_RS08385	COG2832	Protein of unknown function (DUF454)
HPY16_RS08390	COG0745	RESPONSE REGULATOR receiver
HPY16_RS08395	COG0583	DNA-binding transcription factor activity
HPY16_RS08400	COG0778	Nitroreductase
HPY16_RS08405	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY16_RS08405	COG1024	Enoyl-CoA hydratase
HPY16_RS08410	COG0183	Belongs to the thiolase family
HPY16_RS08425	COG2067	long-chain fatty acid transport protein
HPY16_RS08435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY16_RS08440	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY16_RS08445	COG2982	Protein involved in outer membrane biogenesis
HPY16_RS08450	COG0572	uridine kinase
HPY16_RS08455	COG0489	protein tyrosine kinase activity
HPY16_RS08460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_RS08460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY16_RS08470	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY16_RS08480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY16_RS08480	COG0617	tRNA 3'-terminal CCA addition
HPY16_RS08480	COG0517	IMP dehydrogenase activity
HPY16_RS08485	COG2199	diguanylate cyclase activity
HPY16_RS08490	COG0314	molybdopterin synthase activity
HPY16_RS08495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY16_RS08500	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY16_RS08505	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY16_RS08510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY16_RS08515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY16_RS08520	COG2198	Histidine kinase
HPY16_RS08525	COG2204	response regulator
HPY16_RS08530	COG0556	nucleotide-excision repair
HPY16_RS08540	COG4657	Part of a membrane complex involved in electron transport
HPY16_RS08545	COG2878	Part of a membrane complex involved in electron transport
HPY16_RS08550	COG4656	Part of a membrane complex involved in electron transport
HPY16_RS08565	COG4660	Part of a membrane complex involved in electron transport
HPY16_RS08570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY16_RS08575	COG0346	lactoylglutathione lyase activity
HPY16_RS08590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY16_RS08595	COG2056	Na+-H+ antiporter family
HPY16_RS08605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY16_RS08610	COG1286	toxin biosynthetic process
HPY16_RS08615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY16_RS08620	COG0285	dihydrofolate synthase activity
HPY16_RS08625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY16_RS08630	COG0101	tRNA pseudouridine synthase activity
HPY16_RS08645	COG1263	PTS System
HPY16_RS08645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_RS08645	COG2190	(PTS) system
HPY16_RS08650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY16_RS08655	COG1940	carbohydrate kinase activity
HPY16_RS08655	COG1846	Transcriptional regulator
HPY16_RS08660	COG4651	solute:proton antiporter activity
HPY16_RS08660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY16_RS08665	COG0367	asparagine synthase
HPY16_RS08675	COG3104	oligopeptide transport
HPY16_RS08680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY16_RS08685	COG0563	adenylate kinase activity
HPY16_RS08690	COG0326	Molecular chaperone. Has ATPase activity
HPY16_RS08695	COG3710	Transcriptional regulator
HPY16_RS08710	COG0622	Phosphoesterase
HPY16_RS08715	COG1090	epimerase
HPY16_RS08720	COG0300	oxidoreductase activity
HPY16_RS08725	COG3118	belongs to the thioredoxin family
HPY16_RS08730	COG0330	HflC and HflK could
HPY16_RS08735	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY16_RS08740	COG0789	Transcriptional regulator
HPY16_RS08755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY16_RS08760	COG3115	cell septum assembly
HPY16_RS08765	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY16_RS08770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY16_RS08775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS08785	COG2190	(PTS) system
HPY16_RS08790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY16_RS08795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY16_RS08800	COG1702	phosphate starvation-inducible protein PhoH
HPY16_RS08810	COG4535	Mg2 and Co2 transporter CorC
HPY16_RS08815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY16_RS08820	COG2888	peptidyl-tyrosine sulfation
HPY16_RS08825	COG0495	leucyl-tRNA aminoacylation
HPY16_RS08830	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY16_RS08835	COG1466	dna polymerase III delta subunit
HPY16_RS08840	COG0799	negative regulation of ribosome biogenesis
HPY16_RS08845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY16_RS08850	COG0768	penicillin binding
HPY16_RS08855	COG0772	Belongs to the SEDS family
HPY16_RS08860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY16_RS08865	COG1686	Belongs to the peptidase S11 family
HPY16_RS08870	COG2921	Belongs to the UPF0250 family
HPY16_RS08875	COG0321	lipoyl(octanoyl) transferase activity
HPY16_RS08880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY16_RS08890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY16_RS08915	COG1596	polysaccharide export
HPY16_RS08925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY16_RS08955	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY16_RS08965	COG0438	transferase activity, transferring glycosyl groups
HPY16_RS08975	COG1045	serine acetyltransferase
HPY16_RS08995	COG0110	maltose O-acetyltransferase activity
HPY16_RS09000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY16_RS09005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY16_RS09010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY16_RS09015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY16_RS09045	COG0366	Alpha amylase catalytic
HPY16_RS09050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_RS09050	COG1263	PTS System
HPY16_RS09055	COG1609	Transcriptional regulator
HPY16_RS09060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY16_RS09065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY16_RS09070	COG2011	ABC-type metal ion transport system permease component
HPY16_RS09075	COG1464	Belongs to the NlpA lipoprotein family
HPY16_RS09080	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY16_RS09090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY16_RS09090	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY16_RS09100	COG3706	GGDEF domain
HPY16_RS09105	COG1611	Belongs to the LOG family
HPY16_RS09110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY16_RS09115	COG2363	Small membrane protein
HPY16_RS09120	COG0583	DNA-binding transcription factor activity
HPY16_RS09125	COG0301	tRNA thio-modification
HPY16_RS09125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY16_RS09135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY16_RS09140	COG1722	exodeoxyribonuclease VII activity
HPY16_RS09145	COG0142	geranyltranstransferase activity
HPY16_RS09150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY16_RS09155	COG0564	pseudouridine synthase activity
HPY16_RS09160	COG3098	single-species biofilm formation
HPY16_RS09175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS09185	COG1671	Belongs to the UPF0178 family
HPY16_RS09190	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY16_RS09195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY16_RS09200	COG0254	rRNA binding
HPY16_RS09205	COG1720	tRNA m6t6A37 methyltransferase activity
HPY16_RS09210	COG0442	prolyl-tRNA aminoacylation
HPY16_RS09230	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY16_RS09230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY16_RS09240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY16_RS09250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY16_RS09280	COG0484	heat shock protein binding
HPY16_RS09285	COG0443	Heat shock 70 kDa protein
HPY16_RS09290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY16_RS09295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY16_RS09300	COG0497	DNA recombination
HPY16_RS09305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY16_RS09310	COG2914	Belongs to the UPF0125 (RnfH) family
HPY16_RS09315	COG2867	negative regulation of translational initiation
HPY16_RS09320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY16_RS09400	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY16_RS09405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY16_RS09410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY16_RS09430	COG3051	citrate lyase alpha subunit
HPY16_RS09435	COG2301	Belongs to the HpcH HpaI aldolase family
HPY16_RS09445	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY16_RS09455	COG3630	sodium ion export across plasma membrane
HPY16_RS09460	COG0511	ligase activity, forming carbon-carbon bonds
HPY16_RS09460	COG5016	pyruvate
HPY16_RS09465	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY16_RS09475	COG4565	transcriptional regulatory protein
HPY16_RS09505	COG1115	amino acid carrier protein
HPY16_RS09510	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY16_RS09515	COG0583	DNA-binding transcription factor activity
HPY16_RS09525	COG1120	ATPase activity
HPY16_RS09530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_RS09535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_RS09540	COG4592	Periplasmic binding protein
HPY16_RS09550	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_RS09555	COG1169	isochorismate synthase
HPY16_RS09560	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY16_RS09565	COG3433	isochorismatase activity
HPY16_RS09565	COG1535	isochorismatase
HPY16_RS09570	COG1584	GPR1 FUN34 yaaH family protein
HPY16_RS09580	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY16_RS09590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY16_RS09590	COG0519	Catalyzes the synthesis of GMP from XMP
HPY16_RS09595	COG0516	GMP reductase activity
HPY16_RS09595	COG0517	IMP dehydrogenase activity
HPY16_RS09600	COG1570	exodeoxyribonuclease VII activity
HPY16_RS09615	COG1160	GTP binding
HPY16_RS09620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY16_RS09625	COG2976	Protein conserved in bacteria
HPY16_RS09630	COG0124	histidyl-tRNA synthetase
HPY16_RS09635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY16_RS09650	COG0105	UTP biosynthetic process
HPY16_RS09655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY16_RS09660	COG2975	iron-sulfur cluster assembly
HPY16_RS09665	COG0633	Ferredoxin
HPY16_RS09685	COG0822	iron-sulfur transferase activity
HPY16_RS09690	COG1104	cysteine desulfurase activity
HPY16_RS09695	COG1959	2 iron, 2 sulfur cluster binding
HPY16_RS09705	COG0483	inositol monophosphate 1-phosphatase activity
HPY16_RS09710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_RS09715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_RS09720	COG1862	Preprotein translocase
HPY16_RS09730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY16_RS09735	COG0517	IMP dehydrogenase activity
HPY16_RS09745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY16_RS09750	COG0583	DNA-binding transcription factor activity
HPY16_RS09755	COG0450	alkyl hydroperoxide reductase
HPY16_RS09760	COG3142	Participates in the control of copper homeostasis
HPY16_RS09775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY16_RS09780	COG0581	inorganic phosphate transmembrane transporter activity
HPY16_RS09790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY16_RS09795	COG0248	Ppx GppA phosphatase
HPY16_RS09805	COG5002	protein histidine kinase activity
HPY16_RS09810	COG0745	RESPONSE REGULATOR receiver
HPY16_RS09825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY16_RS09870	COG0542	response to heat
HPY16_RS09880	COG0564	pseudouridine synthase activity
HPY16_RS09885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY16_RS09890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY16_RS09895	COG0077	Prephenate dehydratase
HPY16_RS09895	COG1605	Chorismate mutase
HPY16_RS09900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY16_RS09905	COG5001	Diguanylate cyclase
HPY16_RS09915	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY16_RS09925	COG0488	(ABC) transporter
HPY16_RS09935	COG0287	Prephenate dehydrogenase
HPY16_RS09935	COG1605	Chorismate mutase
HPY16_RS09940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY16_RS09945	COG3275	phosphorelay sensor kinase activity
HPY16_RS09950	COG3279	Response regulator of the LytR AlgR family
HPY16_RS09960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY16_RS09965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY16_RS09975	COG1966	Carbon starvation protein
HPY16_RS09980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY16_RS09985	COG1047	Peptidyl-prolyl cis-trans
HPY16_RS09990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY16_RS10000	COG0196	riboflavin kinase activity
HPY16_RS10005	COG0728	peptidoglycan biosynthetic process
HPY16_RS10010	COG0268	Binds directly to 16S ribosomal RNA
HPY16_RS10015	COG0640	Transcriptional regulator
HPY16_RS10020	COG0583	DNA-binding transcription factor activity
HPY16_RS10025	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY16_RS10035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY16_RS10040	COG0730	response to heat
HPY16_RS10045	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY16_RS10050	COG0494	nUDIX hydrolase
HPY16_RS10055	COG3066	DNA modification
HPY16_RS10060	COG0667	Aldo Keto reductase
HPY16_RS10070	COG2204	response regulator
HPY16_RS10075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY16_RS10095	COG0513	Belongs to the DEAD box helicase family
HPY16_RS10120	COG3153	acetyltransferase
HPY16_RS10125	COG3154	lipid carrier protein
HPY16_RS10135	COG0826	peptidase U32
HPY16_RS10140	COG0826	peptidase U32
HPY16_RS10160	COG1185	polyribonucleotide nucleotidyltransferase activity
HPY16_RS10165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY16_RS10175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY16_RS10180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY16_RS10185	COG0195	Participates in both transcription termination and antitermination
HPY16_RS10190	COG0779	Required for maturation of 30S ribosomal subunits
HPY16_RS10205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY16_RS10215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY16_RS10220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY16_RS10225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY16_RS10230	COG1534	Rna-binding protein
HPY16_RS10235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY16_RS10240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY16_RS10245	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY16_RS10250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY16_RS10255	COG0739	heme binding
HPY16_RS10270	COG0316	Belongs to the HesB IscA family
HPY16_RS10280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY16_RS10285	COG0628	permease
HPY16_RS10290	COG2813	Specifically methylates the guanine in position
HPY16_RS10295	COG2205	protein histidine kinase activity
HPY16_RS10295	COG0784	Response regulator, receiver
HPY16_RS10300	COG0747	negative chemotaxis
HPY16_RS10310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_RS10315	COG0444	Belongs to the ABC transporter superfamily
HPY16_RS10320	COG4608	Belongs to the ABC transporter superfamily
HPY16_RS10330	COG2971	BadF BadG BcrA BcrD
HPY16_RS10350	COG3842	ATPase activity
HPY16_RS10360	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY16_RS10365	COG0004	ammonium transporteR
HPY16_RS10370	COG0347	Belongs to the P(II) protein family
HPY16_RS10375	COG3112	Uncharacterised protein family (UPF0231)
HPY16_RS10380	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY16_RS10385	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY16_RS10390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY16_RS10395	COG1643	Atp-dependent helicase
HPY16_RS10405	COG1489	DNA binding
HPY16_RS10415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY16_RS10425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY16_RS10430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY16_RS10435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY16_RS10440	COG0842	Transport permease protein
HPY16_RS10445	COG1131	(ABC) transporter
HPY16_RS10450	COG0659	secondary active sulfate transmembrane transporter activity
HPY16_RS10455	COG0288	reversible hydration of carbon dioxide
HPY16_RS10470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY16_RS10475	COG3107	peptidoglycan biosynthetic process
HPY16_RS10480	COG0792	nuclease activity
HPY16_RS10485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY16_RS10490	COG2823	Periplasmic or secreted lipoprotein
HPY16_RS10495	COG2969	positive regulation of protein catabolic process
HPY16_RS10500	COG0625	glutathione transferase activity
HPY16_RS10505	COG2857	Cytochrome c1
HPY16_RS10510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY16_RS10515	COG0723	plastoquinol--plastocyanin reductase activity
HPY16_RS10520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY16_RS10525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY16_RS10530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY16_RS10540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY16_RS10545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY16_RS10550	COG0335	large ribosomal subunit rRNA binding
HPY16_RS10555	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY16_RS10560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY16_RS10565	COG0228	four-way junction DNA binding
HPY16_RS10570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY16_RS10575	COG4137	Cytochrome C assembly protein
HPY16_RS10580	COG4536	flavin adenine dinucleotide binding
HPY16_RS10585	COG1854	S-ribosylhomocysteine lyase activity
HPY16_RS10590	COG2918	glutathione biosynthetic process
HPY16_RS10595	COG0612	Peptidase, M16
HPY16_RS10600	COG1238	metal cluster binding
HPY16_RS10610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY16_RS10615	COG5016	pyruvate
HPY16_RS10615	COG0511	ligase activity, forming carbon-carbon bonds
HPY16_RS10620	COG3630	sodium ion export across plasma membrane
HPY16_RS10665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY16_RS10670	COG0527	aspartate kinase activity
HPY16_RS10675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY16_RS10685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY16_RS10695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY16_RS10700	COG4208	sulfate ABC transporter
HPY16_RS10720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY16_RS10725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY16_RS10735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY16_RS10740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY16_RS10745	COG0585	pseudouridine synthase activity
HPY16_RS10750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY16_RS10755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY16_RS10760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY16_RS10765	COG1968	undecaprenyl-diphosphatase activity
HPY16_RS10770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY16_RS10775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY16_RS10780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY16_RS10790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY16_RS10795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY16_RS10800	COG1610	YqeY-like protein
HPY16_RS10805	COG0358	DNA primase activity
HPY16_RS10825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY16_RS10830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY16_RS10835	COG1349	DNA-binding transcription factor activity
HPY16_RS10855	COG1279	arginine transmembrane transporter activity
HPY16_RS10860	COG0668	transmembrane transport
HPY16_RS10865	COG0191	fructose-bisphosphate aldolase activity
HPY16_RS10870	COG0126	phosphoglycerate kinase activity
HPY16_RS10875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY16_RS10880	COG4771	TonB-dependent receptor
HPY16_RS10885	COG0583	DNA-binding transcription factor activity
HPY16_RS10890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY16_RS10895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY16_RS10900	COG3091	SprT-like family
HPY16_RS10905	COG2356	endonuclease I
HPY16_RS10910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY16_RS10915	COG0189	ligase activity
HPY16_RS10920	COG1678	Uncharacterized ACR, COG1678
HPY16_RS10925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY16_RS10930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY16_RS10950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY16_RS10955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY16_RS10960	COG0762	integral membrane protein
HPY16_RS10965	COG1872	DUF167
HPY16_RS10975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY16_RS10980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY16_RS10985	COG2066	Belongs to the glutaminase family
HPY16_RS10990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY16_RS10995	COG1194	a g-specific adenine glycosylase
HPY16_RS11000	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY16_RS11005	COG0741	lytic transglycosylase activity
HPY16_RS11030	COG0840	transmembrane signaling receptor activity
HPY16_RS11060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY16_RS11065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY16_RS11070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY16_RS11075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY16_RS11080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY16_RS11085	COG2967	ApaG domain
HPY16_RS11090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY16_RS11100	COG3610	response to peptide
HPY16_RS11105	COG2966	Psort location CytoplasmicMembrane, score
HPY16_RS11110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY16_RS11115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY16_RS11120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY16_RS11125	COG0142	geranyltranstransferase activity
HPY16_RS11130	COG0531	amino acid
HPY16_RS11135	COG0039	L-malate dehydrogenase activity
HPY16_RS11140	COG1438	arginine binding
HPY16_RS11145	COG2358	TRAP transporter, solute receptor (TAXI family
HPY16_RS11155	COG0589	response to stress
HPY16_RS11175	COG2235	arginine
HPY16_RS11180	COG0312	modulator of DNA gyrase
HPY16_RS11185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY16_RS11190	COG3164	Protein of unknown function
HPY16_RS11195	COG1530	ribonuclease E activity
HPY16_RS11200	COG0424	maF-like protein
HPY16_RS11205	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY16_RS11210	COG1792	Involved in formation and maintenance of cell shape
HPY16_RS11215	COG1077	Cell shape determining protein MreB Mrl
HPY16_RS11260	COG1459	type II secretion system
HPY16_RS11265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY16_RS11275	COG3267	Type II secretory pathway component ExeA
HPY16_RS11275	COG3409	Peptidoglycan-binding domain 1 protein
HPY16_RS11300	COG2200	EAL domain
HPY16_RS11300	COG2199	diguanylate cyclase activity
HPY16_RS11305	COG0629	single-stranded DNA binding
HPY16_RS11320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY16_RS11330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY16_RS11335	COG0527	aspartate kinase activity
HPY16_RS11340	COG1410	methionine synthase
HPY16_RS11340	COG0646	methionine synthase
HPY16_RS11415	COG0175	sulfate reduction
HPY16_RS11425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY16_RS11450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY16_RS11455	COG0735	belongs to the Fur family
HPY16_RS11470	COG0166	Belongs to the GPI family
HPY16_RS11475	COG0432	Pfam Uncharacterised protein family UPF0047
HPY16_RS11480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY16_RS11495	COG0359	binds to the 23S rRNA
HPY16_RS11500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY16_RS11505	COG2965	DNA replication, synthesis of RNA primer
HPY16_RS11510	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY16_RS11520	COG2906	2 iron, 2 sulfur cluster binding
HPY16_RS11525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY16_RS11530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY16_RS11535	COG0049	tRNA binding
HPY16_RS11550	COG2923	Belongs to the DsrF TusC family
HPY16_RS11555	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY16_RS11560	COG2964	Protein conserved in bacteria
HPY16_RS11570	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY16_RS11580	COG2900	Belongs to the SlyX family
HPY16_RS11585	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY16_RS11590	COG0330	HflC and HflK could
HPY16_RS11595	COG0330	HflC and HflK could
HPY16_RS11600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY16_RS11605	COG1923	regulation of RNA biosynthetic process
HPY16_RS11610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY16_RS11615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY16_RS11625	COG0802	atpase or kinase
HPY16_RS11630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY16_RS11680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY16_RS11685	COG1162	GTPase activity
HPY16_RS11690	COG0688	phosphatidylethanolamine metabolic process
HPY16_RS11695	COG0471	metal ion transport
HPY16_RS11705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY16_RS11710	COG4942	peptidase
HPY16_RS11725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY16_RS11730	COG2816	NAD+ diphosphatase activity
HPY16_RS11735	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY16_RS11740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY16_RS11745	COG0085	RNA polymerase activity
HPY16_RS11750	COG0222	ribosome binding
HPY16_RS11755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY16_RS11765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY16_RS11770	COG0250	Participates in transcription elongation, termination and antitermination
HPY16_RS11775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY16_RS11780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY16_RS11805	COG1072	(Pantothenic acid kinase))
HPY16_RS11815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY16_RS11825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY16_RS11870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY16_RS11885	COG3118	belongs to the thioredoxin family
HPY16_RS11890	COG0513	Belongs to the DEAD box helicase family
HPY16_RS11900	COG2205	protein histidine kinase activity
HPY16_RS11900	COG0784	Response regulator, receiver
HPY16_RS11905	COG2814	Major facilitator Superfamily
HPY16_RS11920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY16_RS11925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY16_RS11930	COG0511	ligase activity, forming carbon-carbon bonds
HPY16_RS11935	COG0439	Biotin carboxylase
HPY16_RS11940	COG2264	protein methyltransferase activity
HPY16_RS11945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY16_RS11950	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY16_RS11960	COG1609	Transcriptional regulator
HPY16_RS11970	COG0387	Pfam Sodium calcium exchanger
HPY16_RS11975	COG0129	dihydroxy-acid dehydratase activity
HPY16_RS11980	COG3265	gluconokinase activity
HPY16_RS11990	COG0800	Aldolase
HPY16_RS12010	COG0840	transmembrane signaling receptor activity
HPY16_RS12015	COG1982	Orn Lys Arg decarboxylase major
HPY16_RS12020	COG0531	amino acid
HPY16_RS12025	COG3710	Transcriptional regulator
HPY16_RS12030	COG0789	Transcriptional regulator
HPY16_RS12045	COG0151	Belongs to the GarS family
HPY16_RS12055	COG0776	regulation of translation
HPY16_RS12060	COG1253	flavin adenine dinucleotide binding
HPY16_RS12065	COG3068	Protein conserved in bacteria
HPY16_RS12075	COG1573	uracil-dna glycosylase
HPY16_RS12080	COG0668	transmembrane transport
HPY16_RS12100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY16_RS12110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY16_RS12120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY16_RS12180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY16_RS12185	COG0367	asparagine synthase
HPY16_RS12195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPY16_RS12195	COG2755	lipolytic protein G-D-S-L family
HPY16_RS12210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY16_RS12220	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPY16_RS12225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY16_RS12250	COG0859	PFAM glycosyl transferase family 9
HPY16_RS12260	COG1519	Transferase
HPY16_RS12285	COG3642	lipopolysaccharide core region biosynthetic process
HPY16_RS12290	COG0859	PFAM glycosyl transferase family 9
HPY16_RS12295	COG0463	Glycosyl transferase, family 2
HPY16_RS12300	COG0859	PFAM glycosyl transferase family 9
HPY16_RS12305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY16_RS12310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY16_RS12320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY16_RS12325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY16_RS12330	COG2003	Belongs to the UPF0758 family
HPY16_RS12335	COG0840	transmembrane signaling receptor activity
HPY16_RS12340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY16_RS12350	COG1309	transcriptional regulator
HPY16_RS12355	COG1560	Kdo2-lipid A biosynthetic process
HPY16_RS12360	COG1560	Kdo2-lipid A biosynthetic process
HPY16_RS12365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY16_RS12370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY16_RS12375	COG1561	YicC-like family, N-terminal region
HPY16_RS12380	COG2862	Uncharacterized protein family, UPF0114
HPY16_RS12385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY16_RS12390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_RS12390	COG1263	PTS System
HPY16_RS12395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY16_RS12410	COG0514	ATP-dependent DNA helicase (RecQ)
HPY16_RS12415	COG2962	Rard protein
HPY16_RS12420	COG0405	Gamma-glutamyltransferase
HPY16_RS12430	COG1280	lysine exporter protein (LysE YggA)
HPY16_RS12435	COG0210	DNA helicase
HPY16_RS12445	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY16_RS12450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY16_RS12455	COG2131	deaminase
HPY16_RS12465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_RS12475	COG0747	negative chemotaxis
HPY16_RS12525	COG1309	transcriptional regulator
HPY16_RS12530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY16_RS12535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY16_RS12540	COG2960	long-chain fatty acid transporting porin activity
HPY16_RS12545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY16_RS12550	COG0583	DNA-binding transcription factor activity
HPY16_RS12620	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY16_RS12625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY16_RS12630	COG1739	Uncharacterized protein family UPF0029
HPY16_RS12635	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY16_RS12635	COG1024	Enoyl-CoA hydratase
HPY16_RS12640	COG0183	Belongs to the thiolase family
HPY16_RS12645	COG0583	DNA-binding transcription factor activity
HPY16_RS12650	COG2814	Major facilitator Superfamily
HPY16_RS12660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY16_RS12665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY16_RS12670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY16_RS12675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY16_RS12680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY16_RS12685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY16_RS12695	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY16_RS12700	COG3312	ion transport
HPY16_RS12705	COG1475	DNA binding
HPY16_RS12710	COG1192	Involved in chromosome partitioning
HPY16_RS12715	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY16_RS12720	COG0445	tRNA wobble uridine modification
HPY16_RS12725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY16_RS12730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY16_RS12735	COG0706	membrane insertase activity
HPY16_RS12745	COG0594	ribonuclease P activity
HPY16_RS12750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY16_RS12755	COG1126	abc transporter atp-binding protein
HPY16_RS12800	COG0217	transcriptional regulatory protein
HPY16_RS12805	COG2084	Dehydrogenase
HPY16_RS12820	COG2909	trisaccharide binding
HPY16_RS12825	COG0058	SHG alpha-glucan phosphorylase activity
HPY16_RS12830	COG1640	4-alpha-glucanotransferase
HPY16_RS12835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY16_RS12845	COG3501	Rhs element vgr protein
HPY16_RS12880	COG0471	metal ion transport
HPY16_RS12885	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY16_RS12915	COG0671	phosphoesterase, PA-phosphatase related
HPY16_RS12925	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY16_RS12935	COG1999	signal sequence binding
HPY16_RS12950	COG0786	glutamate:sodium symporter activity
HPY16_RS12970	COG1566	PFAM secretion protein HlyD family protein
HPY16_RS12980	COG3706	GGDEF domain
HPY16_RS12995	COG0813	purine-nucleoside phosphorylase activity
HPY16_RS13000	COG3272	Protein of unknown function (DUF1722)
HPY16_RS13010	COG0415	Belongs to the DNA photolyase family
HPY16_RS13015	COG1376	ErfK ybiS ycfS ynhG family protein
HPY16_RS13015	COG1388	LysM domain
HPY16_RS13025	COG0513	Belongs to the DEAD box helicase family
HPY16_RS13030	COG1770	oligopeptidase
HPY16_RS13055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY16_RS13060	COG0573	inorganic phosphate transmembrane transporter activity
HPY16_RS13065	COG0581	inorganic phosphate transmembrane transporter activity
HPY16_RS13070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY16_RS13090	COG0659	secondary active sulfate transmembrane transporter activity
HPY16_RS13100	COG0739	heme binding
HPY16_RS13105	COG3300	MHYT domain
HPY16_RS13105	COG5001	Diguanylate cyclase
HPY16_RS13110	COG0583	DNA-binding transcription factor activity
HPY16_RS13115	COG2814	Major facilitator Superfamily
HPY16_RS13135	COG1301	dicarboxylic acid transport
HPY16_RS13150	COG1342	Belongs to the UPF0251 family
HPY16_RS13185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY16_RS13190	COG0673	inositol 2-dehydrogenase activity
HPY16_RS13200	COG2771	luxR family
HPY16_RS13200	COG2200	EAL domain
HPY16_RS13205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY16_RS13215	COG0564	pseudouridine synthase activity
HPY16_RS13325	COG1869	D-ribose catabolic process
HPY16_RS13330	COG1129	ABC transporter
HPY16_RS13335	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY16_RS13340	COG1879	ABC-type sugar transport system periplasmic component
HPY16_RS13345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_RS13350	COG1609	Transcriptional regulator
HPY16_RS13360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY16_RS13370	COG0584	glycerophosphoryl diester phosphodiesterase
HPY16_RS13375	COG2271	Major facilitator Superfamily
HPY16_RS13410	COG0579	oxidoreductase
HPY16_RS13420	COG0242	peptide deformylase activity
HPY16_RS13435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS13445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY16_RS13445	COG1017	nitric oxide dioxygenase activity
HPY16_RS13450	COG1320	monovalent cation:proton antiporter activity
HPY16_RS13455	COG2212	antiporter activity
HPY16_RS13475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY16_RS13475	COG2111	Na H antiporter
HPY16_RS13485	COG0589	response to stress
HPY16_RS13490	COG0814	amino acid
HPY16_RS13505	COG3530	Putative quorum-sensing-regulated virulence factor
HPY16_RS13515	COG5002	protein histidine kinase activity
HPY16_RS13515	COG5001	Diguanylate cyclase
HPY16_RS13520	COG1278	Cold shock
HPY16_RS13535	COG2304	oxidoreductase activity
HPY16_RS13555	COG0714	Associated with various cellular activities
HPY16_RS13560	COG0840	transmembrane signaling receptor activity
HPY16_RS13575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY16_RS13580	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY16_RS13590	COG3604	Transcriptional regulator
HPY16_RS13595	COG1017	nitric oxide dioxygenase activity
HPY16_RS13595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY16_RS13600	COG1278	Cold shock
HPY16_RS13605	COG3036	rescue of stalled ribosome
HPY16_RS13630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY16_RS13630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY16_RS13635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY16_RS13645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY16_RS13655	COG0516	GMP reductase activity
HPY16_RS13680	COG0513	Belongs to the DEAD box helicase family
HPY16_RS13685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY16_RS13690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY16_RS13695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY16_RS13700	COG3437	response regulator, receiver
HPY16_RS13700	COG0784	Response regulator, receiver
HPY16_RS13710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_RS13710	COG4191	Histidine kinase
HPY16_RS13720	COG1757	Na H antiporter
HPY16_RS13725	COG2814	Major facilitator Superfamily
HPY16_RS13735	COG3240	lipase activity
HPY16_RS13745	COG0840	transmembrane signaling receptor activity
HPY16_RS13750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY16_RS13755	COG5380	lipid catabolic process
HPY16_RS13785	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_RS13790	COG4605	iron ion homeostasis
HPY16_RS13795	COG4604	ABC transporter, ATP-binding protein
HPY16_RS13800	COG2207	Transcriptional regulator
HPY16_RS13815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY16_RS13820	COG0640	Transcriptional regulator
HPY16_RS13825	COG0798	PFAM Bile acid sodium symporter
HPY16_RS13840	COG0583	DNA-binding transcription factor activity
HPY16_RS13855	COG0745	RESPONSE REGULATOR receiver
HPY16_RS13865	COG3623	hexulose-6-phosphate isomerase
HPY16_RS13870	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY16_RS13875	COG0561	phosphatase activity
HPY16_RS13910	COG0366	Alpha amylase catalytic
HPY16_RS13930	COG0745	RESPONSE REGULATOR receiver
HPY16_RS13935	COG5002	protein histidine kinase activity
HPY16_RS13960	COG0583	DNA-binding transcription factor activity
HPY16_RS13975	COG1686	Belongs to the peptidase S11 family
HPY16_RS13995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY16_RS13995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY16_RS14000	COG0509	glycine decarboxylation via glycine cleavage system
HPY16_RS14005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY16_RS14015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY16_RS14030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY16_RS14035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY16_RS14180	COG3549	Plasmid maintenance system killer
HPY16_RS14185	COG3093	addiction module antidote protein HigA
HPY16_RS14325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS14380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS14580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY16_RS14700	COG0346	lactoylglutathione lyase activity
HPY16_RS14765	COG3549	Plasmid maintenance system killer
HPY16_RS14770	COG3093	addiction module antidote protein HigA
HPY16_RS14825	COG2161	toxin-antitoxin pair type II binding
HPY16_RS14830	COG4115	mRNA cleavage
HPY16_RS14910	COG2026	Addiction module toxin, RelE StbE family
HPY16_RS14965	COG0653	protein targeting
HPY16_RS14995	COG5642	Protein of unknown function (DUF2384)
HPY16_RS15020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS15050	COG1418	mRNA catabolic process
HPY16_RS15255	COG0494	nUDIX hydrolase
HPY16_RS15365	COG3613	nucleoside 2-deoxyribosyltransferase
HPY16_RS15390	COG0653	protein targeting
HPY16_RS15425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY16_RS15505	COG0456	acetyltransferase
HPY16_RS15530	COG3040	lipid binding
HPY16_RS15540	COG1028	Short-chain dehydrogenase reductase Sdr
HPY16_RS15655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_RS15655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY16_RS15710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS15750	COG0346	lactoylglutathione lyase activity
HPY16_RS15755	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY16_RS15775	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY16_RS15780	COG2944	sequence-specific DNA binding
HPY16_RS15810	COG3549	Plasmid maintenance system killer
HPY16_RS15815	COG3093	addiction module antidote protein HigA
HPY16_RS15855	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY16_RS15860	COG2885	chlorophyll binding
HPY16_RS15865	COG0840	transmembrane signaling receptor activity
HPY16_RS15870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY16_RS15875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_RS15880	COG1621	beta-fructofuranosidase activity
HPY16_RS15890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY16_RS15890	COG1263	PTS System
HPY16_RS15935	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY16_RS15975	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY16_RS15980	COG0583	DNA-binding transcription factor activity
HPY16_RS16005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY16_RS16040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY16_RS16050	COG2390	Transcriptional regulator
HPY16_RS16055	COG2897	thiosulfate sulfurtransferase activity
HPY16_RS16065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY16_RS16075	COG0302	gtp cyclohydrolase
HPY16_RS16080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_RS16080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY16_RS16085	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY16_RS16090	COG1970	mechanosensitive ion channel activity
HPY16_RS16095	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY16_RS16105	COG1011	Hydrolase
HPY16_RS16110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY16_RS16115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY16_RS16125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY16_RS16130	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY16_RS16135	COG3842	ATPase activity
HPY16_RS16155	COG3104	oligopeptide transport
HPY16_RS16180	COG4166	transmembrane transport
HPY16_RS16185	COG4174	ABC transporter (Permease)
HPY16_RS16190	COG4239	(ABC) transporter, permease
HPY16_RS16195	COG4172	Belongs to the ABC transporter superfamily
HPY16_RS16200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY16_RS16215	COG0625	glutathione transferase activity
HPY16_RS16235	COG2050	protein possibly involved in aromatic compounds catabolism
HPY16_RS16250	COG4771	TonB-dependent receptor
HPY16_RS16255	COG0583	DNA-binding transcription factor activity
HPY16_RS16260	COG1042	CoA-binding domain protein
HPY16_RS16260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS16260	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY16_RS16280	COG0023	Translation Initiation Factor
HPY16_RS16285	COG3140	Belongs to the UPF0181 family
HPY16_RS16300	COG0745	RESPONSE REGULATOR receiver
HPY16_RS16310	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY16_RS16315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY16_RS16330	COG3706	GGDEF domain
HPY16_RS16380	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY16_RS16395	COG0737	Belongs to the 5'-nucleotidase family
HPY16_RS16400	COG3593	DNA synthesis involved in DNA repair
HPY16_RS16410	COG0583	DNA-binding transcription factor activity
HPY16_RS16415	COG2116	formate transmembrane transporter activity
HPY16_RS16425	COG3038	cytochrome b561
HPY16_RS16435	COG2200	EAL domain
HPY16_RS16450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY16_RS16455	COG0745	RESPONSE REGULATOR receiver
HPY16_RS16460	COG2205	protein histidine kinase activity
HPY16_RS16465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY16_RS16465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY16_RS16465	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY16_RS16465	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY16_RS16470	COG3158	transport of potassium into the cell
HPY16_RS16480	COG0523	cobalamin synthesis protein
HPY16_RS16485	COG0038	chloride channel
HPY16_RS16495	COG0156	8-amino-7-oxononanoate synthase activity
HPY16_RS16505	COG0419	ATPase involved in DNA repair
HPY16_RS16510	COG0420	3'-5' exonuclease activity
HPY16_RS16515	COG1609	Transcriptional regulator
HPY16_RS16520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS16520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS16525	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY16_RS16530	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY16_RS16530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_RS16530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY16_RS16535	COG4067	protein conserved in archaea
HPY16_RS16535	COG0189	ligase activity
HPY16_RS16545	COG0602	queuosine metabolic process
HPY16_RS16550	COG1328	CTP reductase activity
HPY16_RS16560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY16_RS16565	COG0840	transmembrane signaling receptor activity
HPY16_RS16570	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY16_RS16575	COG1760	l-serine dehydratase
HPY16_RS16580	COG2197	response regulator
HPY16_RS16585	COG3850	Histidine kinase
HPY16_RS16590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY16_RS16600	COG0243	molybdopterin cofactor binding
HPY16_RS16620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY16_RS16625	COG2197	response regulator
HPY16_RS16630	COG3851	Histidine kinase
HPY16_RS16635	COG2271	Major facilitator Superfamily
HPY16_RS16640	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY16_RS16650	COG3842	ATPase activity
HPY16_RS16655	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY16_RS16665	COG0183	Belongs to the thiolase family
HPY16_RS16675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_RS16680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY16_RS16695	COG3706	GGDEF domain
HPY16_RS16700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY16_RS16710	COG1979	alcohol dehydrogenase
HPY16_RS16725	COG4191	Histidine kinase
HPY16_RS16735	COG2271	Major facilitator Superfamily
HPY16_RS16740	COG0469	pyruvate kinase activity
HPY16_RS16750	COG1879	ABC-type sugar transport system periplasmic component
HPY16_RS16755	COG1803	Methylglyoxal synthase
HPY16_RS16760	COG1335	isochorismatase
HPY16_RS16765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY16_RS16770	COG0210	DNA helicase
HPY16_RS16775	COG1289	transmembrane transporter activity
HPY16_RS16805	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY16_RS16810	COG4149	molybdate abc transporter
HPY16_RS16815	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY16_RS16820	COG1492	cobalamin metabolic process
HPY16_RS16850	COG4977	sequence-specific DNA binding
HPY16_RS16850	COG1917	Cupin 2, conserved barrel domain protein
HPY16_RS16860	COG2814	Major facilitator Superfamily
HPY16_RS16865	COG2226	methyltransferase
HPY16_RS16865	COG3433	isochorismatase activity
HPY16_RS16865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY16_RS16890	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY16_RS16895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY16_RS16915	COG1132	(ABC) transporter
HPY16_RS16920	COG1132	(ABC) transporter
HPY16_RS16930	COG5002	protein histidine kinase activity
HPY16_RS16930	COG0784	Response regulator, receiver
HPY16_RS16935	COG1879	ABC-type sugar transport system periplasmic component
HPY16_RS16945	COG2827	Endonuclease containing a URI domain
HPY16_RS16950	COG3132	Protein of unknown function, DUF480
HPY16_RS16960	COG2926	Belongs to the UPF0265 family
HPY16_RS16970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY16_RS16975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY16_RS16980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY16_RS16990	COG0247	lactate metabolic process
HPY16_RS16995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY16_RS17000	COG3118	belongs to the thioredoxin family
HPY16_RS17025	COG4160	amino acid transport
HPY16_RS17030	COG4215	(ABC) transporter
HPY16_RS17035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_RS17040	COG1126	abc transporter atp-binding protein
HPY16_RS17050	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY16_RS17060	COG0494	nUDIX hydrolase
HPY16_RS17065	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY16_RS17075	COG1309	transcriptional regulator
HPY16_RS17080	COG0513	Belongs to the DEAD box helicase family
HPY16_RS17085	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY16_RS17090	COG0814	amino acid
HPY16_RS17100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY16_RS17105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY16_RS17110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPY16_RS17115	COG1984	allophanate hydrolase subunit 2
HPY16_RS17130	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY16_RS17135	COG4181	ATPase activity
HPY16_RS17145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY16_RS17150	COG1716	ATPase activity
HPY16_RS17150	COG5001	Diguanylate cyclase
HPY16_RS17160	COG0484	heat shock protein binding
HPY16_RS17175	COG0546	phosphoglycolate phosphatase activity
HPY16_RS17190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_RS17200	COG0513	Belongs to the DEAD box helicase family
HPY16_RS17215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY16_RS17225	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY16_RS17230	COG3397	chitin binding
HPY16_RS17235	COG3227	Zinc metalloprotease (Elastase)
HPY16_RS17250	COG1166	arginine decarboxylase activity
HPY16_RS17260	COG2239	Acts as a magnesium transporter
HPY16_RS17270	COG0527	aspartate kinase activity
HPY16_RS17275	COG0662	Cupin 2, conserved barrel domain protein
HPY16_RS17280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY16_RS17285	COG0456	acetyltransferase
HPY16_RS17290	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY16_RS17295	COG3186	Phenylalanine-4-hydroxylase
HPY16_RS17300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY16_RS17315	COG2264	protein methyltransferase activity
HPY16_RS17340	COG1253	flavin adenine dinucleotide binding
HPY16_RS17345	COG1765	OsmC-like protein
HPY16_RS17390	COG1765	OsmC-like protein
HPY16_RS17420	COG1252	NADH dehydrogenase
HPY16_RS17425	COG0531	amino acid
HPY16_RS17430	COG3706	GGDEF domain
HPY16_RS17440	COG4989	oxidoreductase activity
HPY16_RS17445	COG0366	Alpha amylase catalytic
HPY16_RS17455	COG2067	long-chain fatty acid transport protein
HPY16_RS17460	COG2267	carboxylic ester hydrolase activity
HPY16_RS17470	COG3227	Zinc metalloprotease (Elastase)
HPY16_RS17475	COG3047	cAMP biosynthetic process
HPY16_RS17485	COG1686	Belongs to the peptidase S11 family
HPY16_RS17490	COG0557	exoribonuclease II activity
HPY16_RS17495	COG1278	Cold shock
HPY16_RS17505	COG3048	D-serine ammonia-lyase activity
HPY16_RS17510	COG0583	DNA-binding transcription factor activity
HPY16_RS17535	COG5002	protein histidine kinase activity
HPY16_RS17560	COG0582	viral genome integration into host DNA
HPY16_RS17580	COG1063	alcohol dehydrogenase
HPY16_RS17585	COG0156	8-amino-7-oxononanoate synthase activity
HPY16_RS17605	COG0346	lactoylglutathione lyase activity
HPY16_RS17625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY16_RS17630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY16_RS17635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY16_RS17640	COG0363	glucosamine-6-phosphate deaminase activity
HPY16_RS17645	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY16_RS17670	COG1929	Belongs to the glycerate kinase type-1 family
HPY16_RS17675	COG2610	gluconate transmembrane transporter activity
HPY16_RS17680	COG3835	regulator
HPY16_RS17690	COG0748	coenzyme F420 binding
HPY16_RS17695	COG3721	Heme iron utilization protein
HPY16_RS17705	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY16_RS17710	COG0811	peptide transport
HPY16_RS17715	COG0848	biopolymer transport protein
HPY16_RS17720	COG4558	Periplasmic binding protein
HPY16_RS17725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY16_RS17730	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY16_RS17765	COG3217	Mosc domain protein beta barrel domain protein
HPY16_RS17765	COG0633	Ferredoxin
HPY16_RS17765	COG3217	Mosc domain protein beta barrel domain protein
HPY16_RS17765	COG0633	Ferredoxin
HPY16_RS17770	COG0418	dihydroorotase activity
HPY16_RS17775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY16_RS17780	COG2354	Protein conserved in bacteria
HPY16_RS17790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY16_RS17795	COG1278	Cold shock
HPY16_RS17820	COG3706	GGDEF domain
HPY16_RS17825	COG1349	DNA-binding transcription factor activity
HPY16_RS17840	COG3833	ABC-type maltose transport systems, permease component
HPY16_RS17845	COG1175	transmembrane transport
HPY16_RS17855	COG3842	ATPase activity
HPY16_RS17860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY16_RS17875	COG0393	Putative heavy-metal-binding
HPY16_RS17885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY16_RS17890	COG0835	chemotaxis
HPY16_RS17890	COG0784	Response regulator, receiver
HPY16_RS17895	COG1846	Transcriptional regulator
HPY16_RS17900	COG3706	GGDEF domain
HPY16_RS17935	COG0583	DNA-binding transcription factor activity
HPY16_RS17940	COG5001	Diguanylate cyclase
HPY16_RS17950	COG1741	Belongs to the pirin family
HPY16_RS17955	COG3123	guanosine phosphorylase activity
HPY16_RS17965	COG2211	Major facilitator Superfamily
HPY16_RS17975	COG1067	ATP-dependent peptidase activity
HPY16_RS17985	COG4172	Belongs to the ABC transporter superfamily
HPY16_RS18005	COG0583	DNA-binding transcription factor activity
HPY16_RS18015	COG1620	l-lactate permease
HPY16_RS18030	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY16_RS18040	COG0840	transmembrane signaling receptor activity
HPY16_RS18060	COG2258	MOSC domain
HPY16_RS18065	COG0513	Belongs to the DEAD box helicase family
HPY16_RS18075	COG2186	Transcriptional regulator
HPY16_RS18085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY16_RS18095	COG0246	Mannitol dehydrogenase
HPY16_RS18100	COG1904	glucuronate isomerase
HPY16_RS18105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY16_RS18110	COG0800	Aldolase
HPY16_RS18120	COG0583	DNA-binding transcription factor activity
HPY16_RS18130	COG1902	pentaerythritol trinitrate reductase activity
HPY16_RS18140	COG1132	(ABC) transporter
HPY16_RS18150	COG1902	pentaerythritol trinitrate reductase activity
HPY16_RS18160	COG1280	lysine exporter protein (LysE YggA)
HPY16_RS18165	COG2207	Transcriptional regulator
HPY16_RS18185	COG1846	Transcriptional regulator
HPY16_RS18190	COG1764	response to oxidative stress
HPY16_RS18195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY16_RS18200	COG0697	spore germination
HPY16_RS18210	COG0700	Nucleoside recognition
HPY16_RS18215	COG3366	ferrous iron transmembrane transporter activity
HPY16_RS18220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY16_RS18230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY16_RS18245	COG2259	Doxx family
HPY16_RS18270	COG0363	glucosamine-6-phosphate deaminase activity
HPY16_RS18285	COG4580	involved in the transport of maltose and maltodextrins
HPY16_RS18300	COG0840	transmembrane signaling receptor activity
HPY16_RS18310	COG0840	transmembrane signaling receptor activity
HPY16_RS18315	COG3706	GGDEF domain
HPY16_RS18325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY16_RS18330	COG1126	abc transporter atp-binding protein
HPY16_RS18340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY16_RS18345	COG4597	amino acid ABC transporter
HPY16_RS18350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY16_RS18355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY16_RS18355	COG2213	PTS system mannitol-specific
HPY16_RS18360	COG0246	Mannitol dehydrogenase
HPY16_RS18365	COG3722	fumarate hydratase activity
HPY16_RS18400	COG2910	NAD(P)H-binding
HPY16_RS18410	COG0840	transmembrane signaling receptor activity
HPY16_RS18415	COG4221	oxidoreductase activity
HPY16_RS18425	COG1901	pseudouridine methyltransferase
HPY16_RS18440	COG0531	amino acid
HPY16_RS18445	COG1982	Orn Lys Arg decarboxylase major
HPY16_RS18455	COG2197	response regulator
HPY16_RS18505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY16_RS18530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY16_RS18595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY16_RS18600	COG0840	transmembrane signaling receptor activity
HPY16_RS18605	COG0835	chemotaxis
HPY16_RS18610	COG0835	chemotaxis
HPY16_RS18615	COG2198	Histidine kinase
HPY16_RS18615	COG0643	Histidine kinase
HPY16_RS18635	COG0601	transmembrane transport
HPY16_RS18640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY16_RS18645	COG4608	Belongs to the ABC transporter superfamily
HPY16_RS18650	COG2194	sulfuric ester hydrolase activity
HPY16_RS18655	COG0642	Histidine kinase
HPY16_RS18660	COG0745	RESPONSE REGULATOR receiver
HPY16_RS18670	COG4221	oxidoreductase activity
HPY16_RS18690	COG1444	tRNA N-acetyltransferase activity
HPY16_RS18695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine