locus-tag	class	description
VCM66_RS00010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCM66_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VCM66_RS00020	COG0706	membrane insertase activity
VCM66_RS00030	COG0594	ribonuclease P activity
VCM66_RS00035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VCM66_RS00040	COG1126	abc transporter atp-binding protein
VCM66_RS00055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VCM66_RS00060	COG0592	DNA-directed DNA polymerase activity
VCM66_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VCM66_RS00070	COG0187	DNA topoisomerase II activity
VCM66_RS00085	COG0071	Belongs to the small heat shock protein (HSP20) family
VCM66_RS00090	COG3977	Valine--pyruvate aminotransferase
VCM66_RS00095	COG0751	glycine-tRNA ligase activity
VCM66_RS00100	COG0752	glycyl-tRNA synthetase alpha subunit
VCM66_RS00105	COG2119	membrane
VCM66_RS00115	COG0425	Belongs to the sulfur carrier protein TusA family
VCM66_RS00125	COG0604	alcohol dehydrogenase
VCM66_RS00135	COG0129	dihydroxy-acid dehydratase activity
VCM66_RS00140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCM66_RS00155	COG0606	chelatase, subunit chli
VCM66_RS00160	COG0204	Acyl-transferase
VCM66_RS00165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCM66_RS00170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VCM66_RS00180	COG3084	Protein conserved in bacteria
VCM66_RS00190	COG4326	sporulation control protein
VCM66_RS00195	COG1272	protein, Hemolysin III
VCM66_RS00205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCM66_RS00210	COG0569	domain protein
VCM66_RS00215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCM66_RS00215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCM66_RS00225	COG0242	peptide deformylase activity
VCM66_RS00230	COG1652	LysM domain
VCM66_RS00235	COG0758	DNA mediated transformation
VCM66_RS00240	COG2922	Belongs to the Smg family
VCM66_RS00245	COG0551	DNA topoisomerase type I activity
VCM66_RS00250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VCM66_RS00255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VCM66_RS00260	COG0009	L-threonylcarbamoyladenylate synthase
VCM66_RS00270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VCM66_RS00280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VCM66_RS00320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VCM66_RS00325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VCM66_RS00335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCM66_RS00340	COG2104	thiamine diphosphate biosynthetic process
VCM66_RS00345	COG2022	thiamine diphosphate biosynthetic process
VCM66_RS00350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCM66_RS00355	COG0006	proline dipeptidase activity
VCM66_RS00355	COG0006	proline dipeptidase activity
VCM66_RS00375	COG1522	sequence-specific DNA binding
VCM66_RS00380	COG5002	protein histidine kinase activity
VCM66_RS00380	COG5001	Diguanylate cyclase
VCM66_RS00400	COG0589	response to stress
VCM66_RS00410	COG1528	Iron-storage protein
VCM66_RS00420	COG2081	HI0933 family
VCM66_RS00430	COG1322	Protein conserved in bacteria
VCM66_RS00435	COG2226	methyltransferase
VCM66_RS00450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCM66_RS00455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCM66_RS00460	COG0805	protein transport
VCM66_RS00465	COG1858	cytochrome C peroxidase
VCM66_RS00470	COG0534	Mate efflux family protein
VCM66_RS00480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCM66_RS00490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VCM66_RS00495	COG3161	chorismate lyase activity
VCM66_RS00505	COG1580	Controls the rotational direction of flagella during chemotaxis
VCM66_RS00510	COG0840	transmembrane signaling receptor activity
VCM66_RS00520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCM66_RS00530	COG0084	hydrolase, TatD family'
VCM66_RS00545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_RS00545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_RS00565	COG3078	GTPase activator activity
VCM66_RS00580	COG3071	HemY protein
VCM66_RS00585	COG2959	enzyme of heme biosynthesis
VCM66_RS00590	COG1587	Uroporphyrinogen-III synthase
VCM66_RS00595	COG0181	hydroxymethylbilane synthase activity
VCM66_RS00610	COG1965	Belongs to the frataxin family
VCM66_RS00620	COG0019	diaminopimelate decarboxylase activity
VCM66_RS00625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VCM66_RS00635	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VCM66_RS00640	COG1011	Hydrolase
VCM66_RS00645	COG2199	diguanylate cyclase activity
VCM66_RS00645	COG2200	EAL domain
VCM66_RS00645	COG3287	FIST C domain
VCM66_RS00665	COG0561	phosphatase activity
VCM66_RS00670	COG2267	carboxylic ester hydrolase activity
VCM66_RS00675	COG1280	lysine exporter protein (LysE YggA)
VCM66_RS00680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCM66_RS00685	COG0783	Belongs to the Dps family
VCM66_RS00720	COG0742	ribosomal rna small subunit methyltransferase
VCM66_RS00725	COG0552	protein localization to endoplasmic reticulum
VCM66_RS00730	COG2884	Cell division ATP-binding protein ftsE
VCM66_RS00735	COG2177	Part of the ABC transporter FtsEX involved in
VCM66_RS00740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCM66_RS00745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_RS00760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCM66_RS00765	COG4206	TonB-dependent receptor
VCM66_RS00770	COG1404	Belongs to the peptidase S8 family
VCM66_RS00775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VCM66_RS00825	COG0583	DNA-binding transcription factor activity
VCM66_RS00830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VCM66_RS00835	COG2960	long-chain fatty acid transporting porin activity
VCM66_RS00840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCM66_RS00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_RS00850	COG1309	transcriptional regulator
VCM66_RS00905	COG0747	negative chemotaxis
VCM66_RS00910	COG0601	transmembrane transport
VCM66_RS00915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCM66_RS00925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_RS00930	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VCM66_RS00940	COG0210	DNA helicase
VCM66_RS00945	COG1280	lysine exporter protein (LysE YggA)
VCM66_RS00960	COG2962	Rard protein
VCM66_RS00965	COG0514	ATP-dependent DNA helicase (RecQ)
VCM66_RS00980	COG1132	(ABC) transporter
VCM66_RS00985	COG4774	siderophore transport
VCM66_RS00990	COG1120	ATPase activity
VCM66_RS01015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCM66_RS01020	COG1263	PTS System
VCM66_RS01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_RS01025	COG2862	Uncharacterized protein family, UPF0114
VCM66_RS01030	COG1561	YicC-like family, N-terminal region
VCM66_RS01035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCM66_RS01040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VCM66_RS01050	COG1560	Kdo2-lipid A biosynthetic process
VCM66_RS01055	COG1309	transcriptional regulator
VCM66_RS01060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VCM66_RS01070	COG2003	Belongs to the UPF0758 family
VCM66_RS01075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VCM66_RS01080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VCM66_RS01090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VCM66_RS01095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VCM66_RS01100	COG0859	PFAM glycosyl transferase family 9
VCM66_RS01105	COG0463	Glycosyl transferase, family 2
VCM66_RS01110	COG0859	PFAM glycosyl transferase family 9
VCM66_RS01115	COG3642	lipopolysaccharide core region biosynthetic process
VCM66_RS01145	COG1519	Transferase
VCM66_RS01180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCM66_RS01185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VCM66_RS01185	COG0662	Cupin 2, conserved barrel domain protein
VCM66_RS01190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCM66_RS01195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VCM66_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
VCM66_RS01230	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_RS01230	COG1454	alcohol dehydrogenase
VCM66_RS01245	COG5433	transposase activity
VCM66_RS01275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCM66_RS01280	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VCM66_RS01285	COG0668	transmembrane transport
VCM66_RS01290	COG1573	uracil-dna glycosylase
VCM66_RS01300	COG3068	Protein conserved in bacteria
VCM66_RS01310	COG1940	carbohydrate kinase activity
VCM66_RS01315	COG1253	flavin adenine dinucleotide binding
VCM66_RS01325	COG0776	regulation of translation
VCM66_RS01335	COG0151	Belongs to the GarS family
VCM66_RS01345	COG0789	Transcriptional regulator
VCM66_RS01350	COG3710	Transcriptional regulator
VCM66_RS01355	COG0531	amino acid
VCM66_RS01360	COG1982	Orn Lys Arg decarboxylase major
VCM66_RS01365	COG0840	transmembrane signaling receptor activity
VCM66_RS01380	COG0800	Aldolase
VCM66_RS01390	COG3265	gluconokinase activity
VCM66_RS01395	COG0129	dihydroxy-acid dehydratase activity
VCM66_RS01400	COG1609	Transcriptional regulator
VCM66_RS01405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VCM66_RS01410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCM66_RS01420	COG0439	Biotin carboxylase
VCM66_RS01425	COG0511	ligase activity, forming carbon-carbon bonds
VCM66_RS01430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VCM66_RS01435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCM66_RS01455	COG2814	Major facilitator Superfamily
VCM66_RS01460	COG0784	Response regulator, receiver
VCM66_RS01460	COG2205	protein histidine kinase activity
VCM66_RS01465	COG0248	Ppx GppA phosphatase
VCM66_RS01470	COG0513	Belongs to the DEAD box helicase family
VCM66_RS01475	COG3118	belongs to the thioredoxin family
VCM66_RS01490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VCM66_RS01535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VCM66_RS01550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VCM66_RS01560	COG1072	(Pantothenic acid kinase))
VCM66_RS01585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCM66_RS01590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCM66_RS01595	COG0250	Participates in transcription elongation, termination and antitermination
VCM66_RS01600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VCM66_RS01610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VCM66_RS01615	COG0222	ribosome binding
VCM66_RS01620	COG0085	RNA polymerase activity
VCM66_RS01625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VCM66_RS01630	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VCM66_RS01635	COG2816	NAD+ diphosphatase activity
VCM66_RS01640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VCM66_RS01655	COG4942	peptidase
VCM66_RS01660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VCM66_RS01670	COG0471	metal ion transport
VCM66_RS01675	COG0688	phosphatidylethanolamine metabolic process
VCM66_RS01680	COG1162	GTPase activity
VCM66_RS01685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VCM66_RS01730	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VCM66_RS01735	COG0802	atpase or kinase
VCM66_RS01745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VCM66_RS01750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VCM66_RS01755	COG1923	regulation of RNA biosynthetic process
VCM66_RS01760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCM66_RS01765	COG0330	HflC and HflK could
VCM66_RS01770	COG0330	HflC and HflK could
VCM66_RS01775	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VCM66_RS01780	COG2900	Belongs to the SlyX family
VCM66_RS01790	COG0545	Peptidyl-prolyl cis-trans isomerase
VCM66_RS01795	COG2964	Protein conserved in bacteria
VCM66_RS01800	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VCM66_RS01805	COG2923	Belongs to the DsrF TusC family
VCM66_RS01820	COG0049	tRNA binding
VCM66_RS01825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCM66_RS01830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCM66_RS01835	COG2906	2 iron, 2 sulfur cluster binding
VCM66_RS01845	COG0360	Binds together with S18 to 16S ribosomal RNA
VCM66_RS01850	COG2965	DNA replication, synthesis of RNA primer
VCM66_RS01855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VCM66_RS01860	COG0359	binds to the 23S rRNA
VCM66_RS01875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCM66_RS01880	COG0432	Pfam Uncharacterised protein family UPF0047
VCM66_RS01900	COG0735	belongs to the Fur family
VCM66_RS01905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCM66_RS01930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCM66_RS01940	COG0175	sulfate reduction
VCM66_RS01980	COG0646	methionine synthase
VCM66_RS01980	COG1410	methionine synthase
VCM66_RS01985	COG0527	aspartate kinase activity
VCM66_RS01990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCM66_RS02000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VCM66_RS02015	COG0629	single-stranded DNA binding
VCM66_RS02020	COG2199	diguanylate cyclase activity
VCM66_RS02020	COG2200	EAL domain
VCM66_RS02045	COG3267	Type II secretory pathway component ExeA
VCM66_RS02045	COG3409	Peptidoglycan-binding domain 1 protein
VCM66_RS02055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_RS02060	COG1459	type II secretion system
VCM66_RS02070	COG2165	general secretion pathway protein
VCM66_RS02075	COG2165	general secretion pathway protein
VCM66_RS02105	COG1077	Cell shape determining protein MreB Mrl
VCM66_RS02110	COG1792	Involved in formation and maintenance of cell shape
VCM66_RS02115	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VCM66_RS02120	COG0424	maF-like protein
VCM66_RS02130	COG3164	Protein of unknown function
VCM66_RS02135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCM66_RS02140	COG0312	modulator of DNA gyrase
VCM66_RS02145	COG2235	arginine
VCM66_RS02165	COG0589	response to stress
VCM66_RS02175	COG2358	TRAP transporter, solute receptor (TAXI family
VCM66_RS02180	COG1438	arginine binding
VCM66_RS02185	COG0039	L-malate dehydrogenase activity
VCM66_RS02190	COG0531	amino acid
VCM66_RS02195	COG0142	geranyltranstransferase activity
VCM66_RS02200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VCM66_RS02205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VCM66_RS02210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VCM66_RS02215	COG2966	Psort location CytoplasmicMembrane, score
VCM66_RS02220	COG3610	response to peptide
VCM66_RS02230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VCM66_RS02235	COG2967	ApaG domain
VCM66_RS02240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VCM66_RS02245	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VCM66_RS02250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCM66_RS02255	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCM66_RS02260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCM66_RS02290	COG0840	transmembrane signaling receptor activity
VCM66_RS02315	COG0741	lytic transglycosylase activity
VCM66_RS02320	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VCM66_RS02325	COG1194	a g-specific adenine glycosylase
VCM66_RS02335	COG2066	Belongs to the glutaminase family
VCM66_RS02340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCM66_RS02345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VCM66_RS02360	COG0762	integral membrane protein
VCM66_RS02365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VCM66_RS02370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VCM66_RS02390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCM66_RS02395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VCM66_RS02400	COG1678	Uncharacterized ACR, COG1678
VCM66_RS02405	COG0189	ligase activity
VCM66_RS02410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VCM66_RS02415	COG2356	endonuclease I
VCM66_RS02425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VCM66_RS02435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCM66_RS02440	COG0583	DNA-binding transcription factor activity
VCM66_RS02445	COG4771	TonB-dependent receptor
VCM66_RS02450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCM66_RS02455	COG0126	phosphoglycerate kinase activity
VCM66_RS02460	COG0191	fructose-bisphosphate aldolase activity
VCM66_RS02470	COG0668	transmembrane transport
VCM66_RS02475	COG1279	arginine transmembrane transporter activity
VCM66_RS02495	COG1349	DNA-binding transcription factor activity
VCM66_RS02500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VCM66_RS02505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCM66_RS02525	COG0358	DNA primase activity
VCM66_RS02530	COG1610	YqeY-like protein
VCM66_RS02535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VCM66_RS02540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VCM66_RS02550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VCM66_RS02555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VCM66_RS02560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCM66_RS02565	COG1968	undecaprenyl-diphosphatase activity
VCM66_RS02570	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VCM66_RS02575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VCM66_RS02580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VCM66_RS02585	COG0585	pseudouridine synthase activity
VCM66_RS02590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VCM66_RS02595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VCM66_RS02605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCM66_RS02610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VCM66_RS02630	COG4208	sulfate ABC transporter
VCM66_RS02635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VCM66_RS02645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VCM66_RS02655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VCM66_RS02660	COG0527	aspartate kinase activity
VCM66_RS02665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VCM66_RS02715	COG3630	sodium ion export across plasma membrane
VCM66_RS02720	COG5016	pyruvate
VCM66_RS02720	COG0511	ligase activity, forming carbon-carbon bonds
VCM66_RS02725	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCM66_RS02735	COG1238	metal cluster binding
VCM66_RS02740	COG0612	Peptidase, M16
VCM66_RS02745	COG2918	glutathione biosynthetic process
VCM66_RS02750	COG1854	S-ribosylhomocysteine lyase activity
VCM66_RS02755	COG4536	flavin adenine dinucleotide binding
VCM66_RS02760	COG4137	Cytochrome C assembly protein
VCM66_RS02765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VCM66_RS02770	COG0228	four-way junction DNA binding
VCM66_RS02775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VCM66_RS02780	COG0336	Belongs to the RNA methyltransferase TrmD family
VCM66_RS02785	COG0335	large ribosomal subunit rRNA binding
VCM66_RS02790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCM66_RS02795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCM66_RS02805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VCM66_RS02815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VCM66_RS02820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VCM66_RS02825	COG0723	plastoquinol--plastocyanin reductase activity
VCM66_RS02830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VCM66_RS02835	COG2857	Cytochrome c1
VCM66_RS02840	COG0625	glutathione transferase activity
VCM66_RS02845	COG2969	positive regulation of protein catabolic process
VCM66_RS02850	COG2823	Periplasmic or secreted lipoprotein
VCM66_RS02855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCM66_RS02860	COG0792	nuclease activity
VCM66_RS02865	COG3107	peptidoglycan biosynthetic process
VCM66_RS02870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VCM66_RS02885	COG0288	reversible hydration of carbon dioxide
VCM66_RS02890	COG0659	secondary active sulfate transmembrane transporter activity
VCM66_RS02895	COG1131	(ABC) transporter
VCM66_RS02900	COG0842	Transport permease protein
VCM66_RS02905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VCM66_RS02910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VCM66_RS02915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCM66_RS02925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCM66_RS02935	COG1489	DNA binding
VCM66_RS02950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCM66_RS02955	COG1752	Esterase of the alpha-beta hydrolase superfamily
VCM66_RS02960	COG1049	propionate catabolic process, 2-methylcitrate cycle
VCM66_RS02965	COG3112	Uncharacterised protein family (UPF0231)
VCM66_RS02970	COG0347	Belongs to the P(II) protein family
VCM66_RS02975	COG0004	ammonium transporteR
VCM66_RS02980	COG1840	ABC-type Fe3 transport system, periplasmic component
VCM66_RS02990	COG3842	ATPase activity
VCM66_RS03010	COG2971	BadF BadG BcrA BcrD
VCM66_RS03020	COG4608	Belongs to the ABC transporter superfamily
VCM66_RS03025	COG0444	Belongs to the ABC transporter superfamily
VCM66_RS03030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCM66_RS03035	COG0601	transmembrane transport
VCM66_RS03040	COG0747	negative chemotaxis
VCM66_RS03050	COG0784	Response regulator, receiver
VCM66_RS03050	COG2205	protein histidine kinase activity
VCM66_RS03055	COG2813	Specifically methylates the guanine in position
VCM66_RS03060	COG0628	permease
VCM66_RS03070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VCM66_RS03075	COG0316	Belongs to the HesB IscA family
VCM66_RS03090	COG0739	heme binding
VCM66_RS03095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCM66_RS03100	COG2027	D-alanyl-D-alanine carboxypeptidase
VCM66_RS03105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCM66_RS03110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCM66_RS03115	COG1534	Rna-binding protein
VCM66_RS03120	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VCM66_RS03125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VCM66_RS03130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VCM66_RS03140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCM66_RS03155	COG0779	Required for maturation of 30S ribosomal subunits
VCM66_RS03160	COG0195	Participates in both transcription termination and antitermination
VCM66_RS03165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VCM66_RS03170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VCM66_RS03180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VCM66_RS03205	COG0826	peptidase U32
VCM66_RS03210	COG0826	peptidase U32
VCM66_RS03220	COG3154	lipid carrier protein
VCM66_RS03225	COG3153	acetyltransferase
VCM66_RS03250	COG0513	Belongs to the DEAD box helicase family
VCM66_RS03265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VCM66_RS03270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VCM66_RS03275	COG2204	response regulator
VCM66_RS03285	COG0667	Aldo Keto reductase
VCM66_RS03300	COG0494	nUDIX hydrolase
VCM66_RS03305	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VCM66_RS03310	COG0730	response to heat
VCM66_RS03315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VCM66_RS03325	COG1283	sodium-dependent phosphate transmembrane transporter activity
VCM66_RS03330	COG0583	DNA-binding transcription factor activity
VCM66_RS03335	COG0640	Transcriptional regulator
VCM66_RS03340	COG0268	Binds directly to 16S ribosomal RNA
VCM66_RS03345	COG0728	peptidoglycan biosynthetic process
VCM66_RS03350	COG0196	riboflavin kinase activity
VCM66_RS03365	COG1047	Peptidyl-prolyl cis-trans
VCM66_RS03370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VCM66_RS03375	COG1966	Carbon starvation protein
VCM66_RS03390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCM66_RS03395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VCM66_RS03405	COG3279	Response regulator of the LytR AlgR family
VCM66_RS03410	COG3275	phosphorelay sensor kinase activity
VCM66_RS03415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCM66_RS03420	COG1605	Chorismate mutase
VCM66_RS03420	COG0287	Prephenate dehydrogenase
VCM66_RS03430	COG0488	(ABC) transporter
VCM66_RS03440	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VCM66_RS03450	COG5001	Diguanylate cyclase
VCM66_RS03455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCM66_RS03460	COG1605	Chorismate mutase
VCM66_RS03460	COG0077	Prephenate dehydratase
VCM66_RS03465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCM66_RS03470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCM66_RS03475	COG0564	pseudouridine synthase activity
VCM66_RS03485	COG0542	response to heat
VCM66_RS03525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCM66_RS03530	COG0826	peptidase U32
VCM66_RS03540	COG0745	RESPONSE REGULATOR receiver
VCM66_RS03545	COG5002	protein histidine kinase activity
VCM66_RS03555	COG0248	Ppx GppA phosphatase
VCM66_RS03560	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VCM66_RS03570	COG0581	inorganic phosphate transmembrane transporter activity
VCM66_RS03575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCM66_RS03590	COG3142	Participates in the control of copper homeostasis
VCM66_RS03595	COG0450	alkyl hydroperoxide reductase
VCM66_RS03600	COG0583	DNA-binding transcription factor activity
VCM66_RS03605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VCM66_RS03615	COG0517	IMP dehydrogenase activity
VCM66_RS03635	COG1862	Preprotein translocase
VCM66_RS03640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCM66_RS03645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCM66_RS03650	COG0483	inositol monophosphate 1-phosphatase activity
VCM66_RS03660	COG1959	2 iron, 2 sulfur cluster binding
VCM66_RS03670	COG0822	iron-sulfur transferase activity
VCM66_RS03690	COG0633	Ferredoxin
VCM66_RS03695	COG2975	iron-sulfur cluster assembly
VCM66_RS03700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCM66_RS03705	COG0105	UTP biosynthetic process
VCM66_RS03720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VCM66_RS03725	COG0124	histidyl-tRNA synthetase
VCM66_RS03730	COG2976	Protein conserved in bacteria
VCM66_RS03735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCM66_RS03740	COG1160	GTP binding
VCM66_RS03755	COG1570	exodeoxyribonuclease VII activity
VCM66_RS03760	COG0517	IMP dehydrogenase activity
VCM66_RS03760	COG0516	GMP reductase activity
VCM66_RS03765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VCM66_RS03765	COG0519	Catalyzes the synthesis of GMP from XMP
VCM66_RS03775	COG1584	GPR1 FUN34 yaaH family protein
VCM66_RS03780	COG1535	isochorismatase
VCM66_RS03780	COG3433	isochorismatase activity
VCM66_RS03785	COG1021	2,3-dihydroxybenzoate-AMP ligase
VCM66_RS03790	COG1169	isochorismate synthase
VCM66_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
VCM66_RS03805	COG4592	Periplasmic binding protein
VCM66_RS03810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCM66_RS03815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCM66_RS03820	COG1120	ATPase activity
VCM66_RS03830	COG0583	DNA-binding transcription factor activity
VCM66_RS03835	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VCM66_RS03840	COG1115	amino acid carrier protein
VCM66_RS03850	COG0583	DNA-binding transcription factor activity
VCM66_RS03865	COG4565	transcriptional regulatory protein
VCM66_RS03875	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCM66_RS03880	COG0511	ligase activity, forming carbon-carbon bonds
VCM66_RS03880	COG5016	pyruvate
VCM66_RS03885	COG3630	sodium ion export across plasma membrane
VCM66_RS03895	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VCM66_RS03905	COG2301	Belongs to the HpcH HpaI aldolase family
VCM66_RS03910	COG3051	citrate lyase alpha subunit
VCM66_RS03930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCM66_RS03935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VCM66_RS03940	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VCM66_RS04010	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_RS04030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VCM66_RS04035	COG0840	transmembrane signaling receptor activity
VCM66_RS04040	COG3710	Transcriptional regulator
VCM66_RS04050	COG2165	general secretion pathway protein
VCM66_RS04065	COG4796	Type ii and iii secretion system protein
VCM66_RS04085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_RS04090	COG1459	type II secretion system
VCM66_RS04100	COG2207	Transcriptional regulator
VCM66_RS04105	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VCM66_RS04125	COG0739	heme binding
VCM66_RS04135	COG3064	Membrane
VCM66_RS04145	COG0582	viral genome integration into host DNA
VCM66_RS04150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VCM66_RS04155	COG2867	negative regulation of translational initiation
VCM66_RS04160	COG2914	Belongs to the UPF0125 (RnfH) family
VCM66_RS04165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCM66_RS04170	COG0497	DNA recombination
VCM66_RS04175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VCM66_RS04180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VCM66_RS04185	COG0443	Heat shock 70 kDa protein
VCM66_RS04190	COG0484	heat shock protein binding
VCM66_RS04225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCM66_RS04240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VCM66_RS04250	COG0047	phosphoribosylformylglycinamidine synthase activity
VCM66_RS04250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCM66_RS04280	COG0442	prolyl-tRNA aminoacylation
VCM66_RS04285	COG1720	tRNA m6t6A37 methyltransferase activity
VCM66_RS04290	COG0254	rRNA binding
VCM66_RS04295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCM66_RS04300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCM66_RS04305	COG1671	Belongs to the UPF0178 family
VCM66_RS04315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCM66_RS04330	COG3098	single-species biofilm formation
VCM66_RS04335	COG0564	pseudouridine synthase activity
VCM66_RS04340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VCM66_RS04345	COG0142	geranyltranstransferase activity
VCM66_RS04350	COG1722	exodeoxyribonuclease VII activity
VCM66_RS04355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VCM66_RS04365	COG0301	tRNA thio-modification
VCM66_RS04365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCM66_RS04375	COG0583	DNA-binding transcription factor activity
VCM66_RS04380	COG2363	Small membrane protein
VCM66_RS04385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_RS04390	COG1611	Belongs to the LOG family
VCM66_RS04405	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCM66_RS04405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCM66_RS04415	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VCM66_RS04420	COG1464	Belongs to the NlpA lipoprotein family
VCM66_RS04425	COG2011	ABC-type metal ion transport system permease component
VCM66_RS04430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VCM66_RS04435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCM66_RS04440	COG1609	Transcriptional regulator
VCM66_RS04445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_RS04445	COG1263	PTS System
VCM66_RS04450	COG0366	Alpha amylase catalytic
VCM66_RS04480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCM66_RS04485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCM66_RS04490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VCM66_RS04495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VCM66_RS04500	COG0110	maltose O-acetyltransferase activity
VCM66_RS04520	COG1045	serine acetyltransferase
VCM66_RS04530	COG0438	transferase activity, transferring glycosyl groups
VCM66_RS04540	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VCM66_RS04570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCM66_RS04580	COG1596	polysaccharide export
VCM66_RS04605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VCM66_RS04615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VCM66_RS04620	COG0321	lipoyl(octanoyl) transferase activity
VCM66_RS04625	COG2921	Belongs to the UPF0250 family
VCM66_RS04635	COG1686	Belongs to the peptidase S11 family
VCM66_RS04640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCM66_RS04645	COG0772	Belongs to the SEDS family
VCM66_RS04650	COG0768	penicillin binding
VCM66_RS04655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VCM66_RS04660	COG0799	negative regulation of ribosome biogenesis
VCM66_RS04665	COG1466	dna polymerase III delta subunit
VCM66_RS04670	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VCM66_RS04675	COG0495	leucyl-tRNA aminoacylation
VCM66_RS04680	COG2888	peptidyl-tyrosine sulfation
VCM66_RS04685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VCM66_RS04690	COG4535	Mg2 and Co2 transporter CorC
VCM66_RS04700	COG1702	phosphate starvation-inducible protein PhoH
VCM66_RS04705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCM66_RS04710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_RS04715	COG2190	(PTS) system
VCM66_RS04725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_RS04735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VCM66_RS04740	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VCM66_RS04745	COG3115	cell septum assembly
VCM66_RS04750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VCM66_RS04765	COG0789	Transcriptional regulator
VCM66_RS04770	COG1585	Membrane protein implicated in regulation of membrane protease activity
VCM66_RS04775	COG0330	HflC and HflK could
VCM66_RS04780	COG3118	belongs to the thioredoxin family
VCM66_RS04785	COG0300	oxidoreductase activity
VCM66_RS04790	COG1090	epimerase
VCM66_RS04795	COG0622	Phosphoesterase
VCM66_RS04810	COG3710	Transcriptional regulator
VCM66_RS04815	COG0326	Molecular chaperone. Has ATPase activity
VCM66_RS04820	COG0563	adenylate kinase activity
VCM66_RS04825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VCM66_RS04840	COG0367	asparagine synthase
VCM66_RS04845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VCM66_RS04845	COG4651	solute:proton antiporter activity
VCM66_RS04850	COG1846	Transcriptional regulator
VCM66_RS04850	COG1940	carbohydrate kinase activity
VCM66_RS04855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCM66_RS04860	COG2190	(PTS) system
VCM66_RS04860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_RS04860	COG1263	PTS System
VCM66_RS04875	COG0101	tRNA pseudouridine synthase activity
VCM66_RS04880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VCM66_RS04885	COG0285	dihydrofolate synthase activity
VCM66_RS04890	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VCM66_RS04895	COG1286	toxin biosynthetic process
VCM66_RS04900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VCM66_RS04905	COG2056	Na+-H+ antiporter family
VCM66_RS04910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VCM66_RS04930	COG0346	lactoylglutathione lyase activity
VCM66_RS04935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VCM66_RS04955	COG4656	Part of a membrane complex involved in electron transport
VCM66_RS04960	COG2878	Part of a membrane complex involved in electron transport
VCM66_RS04965	COG4657	Part of a membrane complex involved in electron transport
VCM66_RS04975	COG0556	nucleotide-excision repair
VCM66_RS04985	COG2204	response regulator
VCM66_RS04990	COG2198	Histidine kinase
VCM66_RS04995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VCM66_RS05000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VCM66_RS05005	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCM66_RS05010	COG0315	cyclic pyranopterin monophosphate synthase activity
VCM66_RS05015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VCM66_RS05020	COG0314	molybdopterin synthase activity
VCM66_RS05025	COG2199	diguanylate cyclase activity
VCM66_RS05030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VCM66_RS05030	COG0617	tRNA 3'-terminal CCA addition
VCM66_RS05030	COG0517	IMP dehydrogenase activity
VCM66_RS05045	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VCM66_RS05055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_RS05055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_RS05060	COG0489	protein tyrosine kinase activity
VCM66_RS05070	COG0572	uridine kinase
VCM66_RS05075	COG2982	Protein involved in outer membrane biogenesis
VCM66_RS05080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VCM66_RS05085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCM66_RS05095	COG2067	long-chain fatty acid transport protein
VCM66_RS05115	COG0183	Belongs to the thiolase family
VCM66_RS05120	COG1024	Enoyl-CoA hydratase
VCM66_RS05120	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCM66_RS05125	COG0778	Nitroreductase
VCM66_RS05130	COG0583	DNA-binding transcription factor activity
VCM66_RS05135	COG0745	RESPONSE REGULATOR receiver
VCM66_RS05145	COG2832	Protein of unknown function (DUF454)
VCM66_RS05150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VCM66_RS05160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VCM66_RS05165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VCM66_RS05175	COG2983	Belongs to the UPF0260 family
VCM66_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
VCM66_RS05185	COG0616	signal peptide processing
VCM66_RS05195	COG1522	sequence-specific DNA binding
VCM66_RS05200	COG1946	Acyl-CoA thioesterase
VCM66_RS05220	COG3706	GGDEF domain
VCM66_RS05225	COG0640	Transcriptional regulator
VCM66_RS05230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCM66_RS05255	COG1881	PFAM PEBP family protein
VCM66_RS05275	COG0009	L-threonylcarbamoyladenylate synthase
VCM66_RS05290	COG2201	protein-glutamate methylesterase activity
VCM66_RS05300	COG5002	protein histidine kinase activity
VCM66_RS05310	COG5001	Diguanylate cyclase
VCM66_RS05310	COG3300	MHYT domain
VCM66_RS05315	COG2204	response regulator
VCM66_RS05335	COG0601	transmembrane transport
VCM66_RS05340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCM66_RS05345	COG0444	Belongs to the ABC transporter superfamily
VCM66_RS05350	COG4608	Belongs to the ABC transporter superfamily
VCM66_RS05355	COG0435	Glutathione S-transferase
VCM66_RS05360	COG0857	belongs to the CobB CobQ family
VCM66_RS05360	COG0280	phosphate acetyltransferase
VCM66_RS05365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCM66_RS05370	COG3092	negative regulation of chromosome organization
VCM66_RS05375	COG4628	conserved protein (DUF2132)
VCM66_RS05385	COG4120	Belongs to the binding-protein-dependent transport system permease family
VCM66_RS05395	COG2203	Gaf domain
VCM66_RS05395	COG2199	diguanylate cyclase activity
VCM66_RS05400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCM66_RS05410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VCM66_RS05415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VCM66_RS05420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VCM66_RS05425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VCM66_RS05430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCM66_RS05435	COG0156	8-amino-7-oxononanoate synthase activity
VCM66_RS05440	COG2226	methyltransferase
VCM66_RS05445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VCM66_RS05455	COG0501	Belongs to the peptidase M48B family
VCM66_RS05465	COG0300	oxidoreductase activity
VCM66_RS05480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VCM66_RS05490	COG2268	Band 7 protein
VCM66_RS05500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VCM66_RS05505	COG2915	High frequency lysogenization protein hflD homolog
VCM66_RS05510	COG0482	sulfurtransferase activity
VCM66_RS05515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCM66_RS05520	COG2916	Histone family protein nucleoid-structuring protein H-NS
VCM66_RS05525	COG1757	Na H antiporter
VCM66_RS05530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VCM66_RS05535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VCM66_RS05540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VCM66_RS05545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCM66_RS05545	COG0131	Imidazoleglycerol-phosphate dehydratase
VCM66_RS05550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VCM66_RS05555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VCM66_RS05560	COG0107	imidazoleglycerol-phosphate synthase activity
VCM66_RS05565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VCM66_RS05565	COG0140	phosphoribosyl-ATP diphosphatase activity
VCM66_RS05570	COG1187	pseudouridine synthase activity
VCM66_RS05580	COG1278	Cold shock
VCM66_RS05585	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VCM66_RS05590	COG0542	response to heat
VCM66_RS05595	COG2985	domain, Protein
VCM66_RS05595	COG3273	potassium ion transport
VCM66_RS05600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCM66_RS05605	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_RS05605	COG1454	alcohol dehydrogenase
VCM66_RS05610	COG1737	Transcriptional regulator
VCM66_RS05615	COG0076	glutamate decarboxylase activity
VCM66_RS05625	COG2431	L-lysine efflux transmembrane transporter activity
VCM66_RS05635	COG3070	regulator of competence-specific genes
VCM66_RS05650	COG3852	Histidine kinase
VCM66_RS05660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VCM66_RS05675	COG0189	ligase activity
VCM66_RS05675	COG4067	protein conserved in archaea
VCM66_RS05680	COG0500	methyltransferase
VCM66_RS05685	COG4106	trans-aconitate 2-methyltransferase activity
VCM66_RS05690	COG1801	Protein of unknown function DUF72
VCM66_RS05695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VCM66_RS05700	COG1435	thymidine kinase activity
VCM66_RS05710	COG0159	tryptophan synthase activity
VCM66_RS05715	COG0133	tryptophan synthase activity
VCM66_RS05720	COG0135	phosphoribosylanthranilate isomerase activity
VCM66_RS05720	COG0134	indole-3-glycerol-phosphate synthase activity
VCM66_RS05725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VCM66_RS05730	COG0512	Glutamine amidotransferase of anthranilate synthase
VCM66_RS05735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCM66_RS05745	COG0613	PHP domain protein
VCM66_RS05750	COG0009	L-threonylcarbamoyladenylate synthase
VCM66_RS05755	COG1187	pseudouridine synthase activity
VCM66_RS05760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VCM66_RS05765	COG4988	ABC transporter
VCM66_RS05770	COG0492	ferredoxin-NADP+ reductase activity
VCM66_RS05780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCM66_RS05785	COG3706	GGDEF domain
VCM66_RS05790	COG2949	membrane
VCM66_RS05800	COG0281	malic enzyme
VCM66_RS05810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VCM66_RS05830	COG2885	chlorophyll binding
VCM66_RS05845	COG0277	FAD linked oxidase domain protein
VCM66_RS05845	COG0247	lactate metabolic process
VCM66_RS05865	COG2986	histidine ammonia-lyase
VCM66_RS05870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VCM66_RS05875	COG0010	Belongs to the arginase family
VCM66_RS05880	COG1228	amidohydrolase
VCM66_RS05895	COG3099	Belongs to the UPF0263 family
VCM66_RS05900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCM66_RS05910	COG5001	Diguanylate cyclase
VCM66_RS05915	COG0417	DNA replication proofreading
VCM66_RS05920	COG2197	response regulator
VCM66_RS05925	COG0322	excinuclease ABC activity
VCM66_RS05965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VCM66_RS05970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_RS05970	COG0072	phenylalanine-tRNA ligase activity
VCM66_RS05975	COG0776	regulation of translation
VCM66_RS06015	COG1346	cytolysis
VCM66_RS06020	COG1380	Effector of murein hydrolase LrgA
VCM66_RS06025	COG2925	Exonuclease
VCM66_RS06030	COG1823	symporter activity
VCM66_RS06035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_RS06040	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VCM66_RS06045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VCM66_RS06065	COG4139	cobalamin transport
VCM66_RS06115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCM66_RS06120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCM66_RS06125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCM66_RS06135	COG1054	Belongs to the UPF0176 family
VCM66_RS06145	COG2814	Major facilitator Superfamily
VCM66_RS06155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCM66_RS06180	COG2989	Protein conserved in bacteria
VCM66_RS06185	COG3108	Peptidase M15
VCM66_RS06190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCM66_RS06205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCM66_RS06230	COG1846	Transcriptional regulator
VCM66_RS06235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCM66_RS06240	COG0726	polysaccharide deacetylase
VCM66_RS06245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCM66_RS06255	COG1447	Phosphotransferase system cellobiose-specific component IIA
VCM66_RS06260	COG1486	melibiose metabolic process
VCM66_RS06270	COG1609	Transcriptional regulator
VCM66_RS06280	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VCM66_RS06285	COG0840	transmembrane signaling receptor activity
VCM66_RS06300	COG1448	Aminotransferase
VCM66_RS06310	COG2770	Histidine kinase
VCM66_RS06310	COG3437	response regulator, receiver
VCM66_RS06315	COG0351	phosphomethylpyrimidine kinase
VCM66_RS06320	COG0017	Asparaginyl-tRNA synthetase
VCM66_RS06325	COG0840	transmembrane signaling receptor activity
VCM66_RS06330	COG0720	synthase
VCM66_RS06335	COG1760	l-serine dehydratase
VCM66_RS06340	COG0814	amino acid
VCM66_RS06345	COG0494	nUDIX hydrolase
VCM66_RS06350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCM66_RS06365	COG3106	COG3106 Predicted ATPase
VCM66_RS06370	COG3768	UPF0283 membrane protein
VCM66_RS06380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCM66_RS06395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCM66_RS06405	COG0471	metal ion transport
VCM66_RS06410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCM66_RS06410	COG4191	Histidine kinase
VCM66_RS06420	COG2990	Protein conserved in bacteria
VCM66_RS06425	COG3713	MltA-interacting MipA family protein
VCM66_RS06430	COG2205	protein histidine kinase activity
VCM66_RS06435	COG0745	RESPONSE REGULATOR receiver
VCM66_RS06470	COG1129	ABC transporter
VCM66_RS06510	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VCM66_RS06515	COG0372	Belongs to the citrate synthase family
VCM66_RS06545	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCM66_RS06555	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VCM66_RS06565	COG0625	glutathione transferase activity
VCM66_RS06570	COG3437	response regulator, receiver
VCM66_RS06575	COG4999	Histidine kinase
VCM66_RS06575	COG3850	Histidine kinase
VCM66_RS06575	COG2205	protein histidine kinase activity
VCM66_RS06575	COG3437	response regulator, receiver
VCM66_RS06590	COG3706	GGDEF domain
VCM66_RS06595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCM66_RS06600	COG1254	Belongs to the acylphosphatase family
VCM66_RS06605	COG2920	part of a sulfur-relay system
VCM66_RS06610	COG0670	Belongs to the BI1 family
VCM66_RS06615	COG1126	abc transporter atp-binding protein
VCM66_RS06620	COG0765	amino acid transport
VCM66_RS06625	COG4597	amino acid ABC transporter
VCM66_RS06630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCM66_RS06640	COG0561	phosphatase activity
VCM66_RS06645	COG0602	queuosine metabolic process
VCM66_RS06650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VCM66_RS06680	COG3706	GGDEF domain
VCM66_RS06685	COG0443	Heat shock 70 kDa protein
VCM66_RS06690	COG0443	Heat shock 70 kDa protein
VCM66_RS06730	COG1643	Atp-dependent helicase
VCM66_RS06740	COG0443	Heat shock 70 kDa protein
VCM66_RS06745	COG0095	Lipoate-protein ligase
VCM66_RS06755	COG0583	DNA-binding transcription factor activity
VCM66_RS06760	COG0477	Major facilitator Superfamily
VCM66_RS06765	COG0415	Belongs to the DNA photolyase family
VCM66_RS06780	COG0745	RESPONSE REGULATOR receiver
VCM66_RS06790	COG0643	Histidine kinase
VCM66_RS06790	COG2198	Histidine kinase
VCM66_RS06795	COG2198	Histidine kinase
VCM66_RS06795	COG0643	Histidine kinase
VCM66_RS06795	COG0784	Response regulator, receiver
VCM66_RS06800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCM66_RS06810	COG2201	protein-glutamate methylesterase activity
VCM66_RS06815	COG0835	chemotaxis
VCM66_RS06820	COG3290	protein histidine kinase activity
VCM66_RS06820	COG0840	transmembrane signaling receptor activity
VCM66_RS06825	COG0840	transmembrane signaling receptor activity
VCM66_RS06835	COG0513	Belongs to the DEAD box helicase family
VCM66_RS06845	COG1538	Outer membrane efflux protein
VCM66_RS06850	COG1566	PFAM secretion protein HlyD family protein
VCM66_RS06855	COG2814	Major facilitator Superfamily
VCM66_RS06865	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VCM66_RS06875	COG3501	Rhs element vgr protein
VCM66_RS06885	COG3675	Pfam Lipase (class 3)
VCM66_RS06900	COG1280	lysine exporter protein (LysE YggA)
VCM66_RS06905	COG1115	amino acid carrier protein
VCM66_RS06920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCM66_RS06930	COG1177	transmembrane transport
VCM66_RS06935	COG1176	ABC-type spermidine putrescine transport system, permease component I
VCM66_RS06940	COG3842	ATPase activity
VCM66_RS06965	COG0589	response to stress
VCM66_RS06970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCM66_RS06985	COG2217	Heavy metal translocating P-type atpase
VCM66_RS06995	COG2010	Cytochrome c
VCM66_RS07010	COG3278	Belongs to the heme-copper respiratory oxidase family
VCM66_RS07025	COG2205	protein histidine kinase activity
VCM66_RS07025	COG0784	Response regulator, receiver
VCM66_RS07050	COG2994	toxin metabolic process
VCM66_RS07055	COG3064	Membrane
VCM66_RS07055	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VCM66_RS07055	COG1073	alpha beta
VCM66_RS07140	COG3120	sequence-specific DNA binding
VCM66_RS07145	COG1067	ATP-dependent peptidase activity
VCM66_RS07150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCM66_RS07165	COG0488	(ABC) transporter
VCM66_RS07175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCM66_RS07175	COG0116	Belongs to the methyltransferase superfamily
VCM66_RS07185	COG0167	dihydroorotate dehydrogenase activity
VCM66_RS07200	COG0308	aminopeptidase N
VCM66_RS07215	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VCM66_RS07220	COG1956	GAF domain-containing protein
VCM66_RS07225	COG1132	(ABC) transporter
VCM66_RS07230	COG2995	paraquat-inducible protein a
VCM66_RS07235	COG3008	intermembrane lipid transfer
VCM66_RS07245	COG2996	Protein conserved in bacteria
VCM66_RS07260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCM66_RS07265	COG1666	GTP binding
VCM66_RS07270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VCM66_RS07285	COG0437	4 iron, 4 sulfur cluster binding
VCM66_RS07290	COG3383	formate dehydrogenase (NAD+) activity
VCM66_RS07290	COG0243	molybdopterin cofactor binding
VCM66_RS07320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VCM66_RS07325	COG0488	(ABC) transporter
VCM66_RS07330	COG3852	Histidine kinase
VCM66_RS07335	COG2204	response regulator
VCM66_RS07345	COG4662	Binding-protein-dependent transport system inner membrane component
VCM66_RS07350	COG3842	ATPase activity
VCM66_RS07355	COG0746	molybdenum cofactor guanylyltransferase activity
VCM66_RS07385	COG1940	carbohydrate kinase activity
VCM66_RS07390	COG3148	PFAM DTW domain containing protein
VCM66_RS07400	COG0840	transmembrane signaling receptor activity
VCM66_RS07405	COG0791	NLP P60 protein
VCM66_RS07415	COG3001	Fructosamine kinase
VCM66_RS07425	COG0534	Mate efflux family protein
VCM66_RS07435	COG1793	dna ligase
VCM66_RS07445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCM66_RS07450	COG0848	biopolymer transport protein
VCM66_RS07455	COG0811	peptide transport
VCM66_RS07460	COG0811	peptide transport
VCM66_RS07475	COG1175	transmembrane transport
VCM66_RS07480	COG0395	ABC-type sugar transport system, permease component
VCM66_RS07485	COG3842	ATPase activity
VCM66_RS07490	COG1349	DNA-binding transcription factor activity
VCM66_RS07495	COG0584	glycerophosphoryl diester phosphodiesterase
VCM66_RS07500	COG2731	YhcH YjgK YiaL family protein
VCM66_RS07505	COG0251	oxidation-reduction process
VCM66_RS07510	COG1609	Transcriptional regulator
VCM66_RS07515	COG2723	6-phospho-beta-galactosidase activity
VCM66_RS07525	COG0583	DNA-binding transcription factor activity
VCM66_RS07545	COG1136	(ABC) transporter
VCM66_RS07545	COG0577	efflux transmembrane transporter activity
VCM66_RS07550	COG1136	(ABC) transporter
VCM66_RS07550	COG0577	efflux transmembrane transporter activity
VCM66_RS07555	COG1136	(ABC) transporter
VCM66_RS07555	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCM66_RS07560	COG1294	oxidase, subunit
VCM66_RS07565	COG1271	oxidase subunit
VCM66_RS07605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCM66_RS07615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VCM66_RS07635	COG0753	catalase activity
VCM66_RS07650	COG3527	Alpha-acetolactate decarboxylase
VCM66_RS07665	COG2199	diguanylate cyclase activity
VCM66_RS07665	COG2200	EAL domain
VCM66_RS07675	COG2017	converts alpha-aldose to the beta-anomer
VCM66_RS07680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VCM66_RS07685	COG1085	galactose-1-phosphate uridylyltransferase
VCM66_RS07725	COG0835	chemotaxis
VCM66_RS07725	COG0784	Response regulator, receiver
VCM66_RS07735	COG4565	transcriptional regulatory protein
VCM66_RS07740	COG3290	protein histidine kinase activity
VCM66_RS07755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_RS07775	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VCM66_RS07780	COG3063	Type IV pilus biogenesis stability protein PilW
VCM66_RS07795	COG1451	nucleotide metabolic process
VCM66_RS07805	COG0583	DNA-binding transcription factor activity
VCM66_RS07825	COG1538	Outer membrane efflux protein
VCM66_RS07840	COG1748	Saccharopine dehydrogenase
VCM66_RS07850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCM66_RS07860	COG0577	efflux transmembrane transporter activity
VCM66_RS07865	COG4181	ATPase activity
VCM66_RS07870	COG0534	Mate efflux family protein
VCM66_RS07875	COG0702	epimerase
VCM66_RS07885	COG2814	Major facilitator Superfamily
VCM66_RS07890	COG1187	pseudouridine synthase activity
VCM66_RS07895	COG1061	Type III restriction enzyme res subunit
VCM66_RS07915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VCM66_RS07920	COG2203	Gaf domain
VCM66_RS07920	COG5001	Diguanylate cyclase
VCM66_RS07920	COG4251	negative regulation of phosphorylation
VCM66_RS07920	COG3706	GGDEF domain
VCM66_RS07935	COG0840	transmembrane signaling receptor activity
VCM66_RS07965	COG4934	collagen metabolic process
VCM66_RS07980	COG2205	protein histidine kinase activity
VCM66_RS07980	COG0784	Response regulator, receiver
VCM66_RS07985	COG2239	Acts as a magnesium transporter
VCM66_RS07995	COG0814	amino acid
VCM66_RS08000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_RS08005	COG1131	(ABC) transporter
VCM66_RS08010	COG0842	Transport permease protein
VCM66_RS08020	COG3313	Fe-S protein
VCM66_RS08030	COG4134	Bacterial extracellular solute-binding protein
VCM66_RS08035	COG4135	transport system, permease component
VCM66_RS08040	COG4136	ATPase activity
VCM66_RS08045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VCM66_RS08050	COG0564	pseudouridine synthase activity
VCM66_RS08055	COG0733	neurotransmitter:sodium symporter activity
VCM66_RS08065	COG0626	cystathionine gamma-synthase activity
VCM66_RS08070	COG2818	Glycosylase
VCM66_RS08085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_RS08100	COG1842	Phage shock protein A
VCM66_RS08105	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VCM66_RS08115	COG4168	peptide transport system, permease
VCM66_RS08130	COG4172	Belongs to the ABC transporter superfamily
VCM66_RS08145	COG1227	inorganic diphosphatase activity
VCM66_RS08165	COG0243	molybdopterin cofactor binding
VCM66_RS08170	COG3005	denitrification pathway
VCM66_RS08175	COG4459	periplasmic nitrate reductase
VCM66_RS08185	COG2116	formate transmembrane transporter activity
VCM66_RS08195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCM66_RS08200	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCM66_RS08215	COG1607	acyl-coa hydrolase
VCM66_RS08220	COG2350	Protein conserved in bacteria
VCM66_RS08230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VCM66_RS08235	COG0583	DNA-binding transcription factor activity
VCM66_RS08250	COG0612	Peptidase, M16
VCM66_RS08255	COG5001	Diguanylate cyclase
VCM66_RS08260	COG1032	radical SAM domain protein
VCM66_RS08280	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VCM66_RS08290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCM66_RS08295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCM66_RS08300	COG0745	RESPONSE REGULATOR receiver
VCM66_RS08310	COG1609	Transcriptional regulator
VCM66_RS08315	COG3070	regulator of competence-specific genes
VCM66_RS08335	COG0297	glycogen (starch) synthase activity
VCM66_RS08340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VCM66_RS08345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCM66_RS08375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VCM66_RS08380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCM66_RS08405	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_RS08410	COG1309	transcriptional regulator
VCM66_RS08435	COG0668	transmembrane transport
VCM66_RS08440	COG2995	paraquat-inducible protein a
VCM66_RS08445	COG3008	intermembrane lipid transfer
VCM66_RS08445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCM66_RS08455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCM66_RS08470	COG0582	viral genome integration into host DNA
VCM66_RS08480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCM66_RS08500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCM66_RS08520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCM66_RS08540	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCM66_RS08545	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCM66_RS08550	COG1737	Transcriptional regulator
VCM66_RS08555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCM66_RS08560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCM66_RS08565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCM66_RS08570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCM66_RS08585	COG1940	carbohydrate kinase activity
VCM66_RS08590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCM66_RS08595	COG4409	exo-alpha-(2->6)-sialidase activity
VCM66_RS08605	COG2003	Belongs to the UPF0758 family
VCM66_RS08660	COG0415	Belongs to the DNA photolyase family
VCM66_RS08670	COG4628	conserved protein (DUF2132)
VCM66_RS08675	COG3284	Transcriptional regulator
VCM66_RS08680	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_RS08690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_RS08695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_RS08700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_RS08710	COG2207	Transcriptional regulator
VCM66_RS08715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_RS08715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCM66_RS08715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_RS08720	COG1482	cell wall glycoprotein biosynthetic process
VCM66_RS08730	COG0784	Response regulator, receiver
VCM66_RS08730	COG5002	protein histidine kinase activity
VCM66_RS08740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VCM66_RS08750	COG2885	chlorophyll binding
VCM66_RS08755	COG0823	Involved in the tonB-independent uptake of proteins
VCM66_RS08770	COG0811	peptide transport
VCM66_RS08775	COG0824	Thioesterase
VCM66_RS08780	COG3790	cyd operon protein YbgE
VCM66_RS08785	COG4890	Cyd operon protein YbgT
VCM66_RS08790	COG1294	oxidase, subunit
VCM66_RS08795	COG1271	oxidase subunit
VCM66_RS08805	COG0632	four-way junction helicase activity
VCM66_RS08810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VCM66_RS08815	COG0215	cysteine-tRNA ligase activity
VCM66_RS08820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCM66_RS08825	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_RS08830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCM66_RS08835	COG3012	SEC-C Motif Domain Protein
VCM66_RS08840	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCM66_RS08845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCM66_RS08850	COG1199	ATP-dependent helicase activity
VCM66_RS08855	COG0730	response to heat
VCM66_RS08860	COG3923	Primosomal replication protein n
VCM66_RS08870	COG0840	transmembrane signaling receptor activity
VCM66_RS08875	COG0708	Exodeoxyribonuclease III
VCM66_RS08880	COG4160	amino acid transport
VCM66_RS08905	COG1882	Formate acetyltransferase
VCM66_RS08915	COG0840	transmembrane signaling receptor activity
VCM66_RS08920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VCM66_RS08930	COG3013	Belongs to the UPF0304 family
VCM66_RS08935	COG2766	serine protein kinase
VCM66_RS08940	COG2718	Belongs to the UPF0229 family
VCM66_RS08945	COG2719	SpoVR family
VCM66_RS08955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VCM66_RS08960	COG2835	tetraacyldisaccharide 4'-kinase activity
VCM66_RS08965	COG1663	tetraacyldisaccharide 4'-kinase activity
VCM66_RS08970	COG1132	(ABC) transporter
VCM66_RS08975	COG0658	competence protein
VCM66_RS08975	COG2333	competence protein COMEC
VCM66_RS08985	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCM66_RS08990	COG1136	(ABC) transporter
VCM66_RS08995	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCM66_RS09005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VCM66_RS09025	COG1252	NADH dehydrogenase
VCM66_RS09030	COG3150	esterase
VCM66_RS09055	COG0537	adenosine 5'-monophosphoramidase activity
VCM66_RS09070	COG2186	Transcriptional regulator
VCM66_RS09075	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCM66_RS09080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VCM66_RS09085	COG1674	ftsk spoiiie
VCM66_RS09095	COG0686	Belongs to the AlaDH PNT family
VCM66_RS09105	COG0583	DNA-binding transcription factor activity
VCM66_RS09125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VCM66_RS09130	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VCM66_RS09135	COG0776	regulation of translation
VCM66_RS09140	COG0539	negative regulation of cytoplasmic translation
VCM66_RS09145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VCM66_RS09150	COG1555	photosystem II stabilization
VCM66_RS09155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCM66_RS09160	COG0776	regulation of translation
VCM66_RS09165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VCM66_RS09170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VCM66_RS09180	COG0544	peptidyl-prolyl cis-trans isomerase activity
VCM66_RS09190	COG4191	Histidine kinase
VCM66_RS09200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCM66_RS09205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCM66_RS09210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCM66_RS09215	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VCM66_RS09230	COG3300	MHYT domain
VCM66_RS09230	COG5001	Diguanylate cyclase
VCM66_RS09240	COG4589	Belongs to the CDS family
VCM66_RS09275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VCM66_RS09285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_RS09300	COG0243	molybdopterin cofactor binding
VCM66_RS09305	COG3005	denitrification pathway
VCM66_RS09310	COG3469	chitinase activity
VCM66_RS09310	COG3325	Belongs to the glycosyl hydrolase 18 family
VCM66_RS09315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCM66_RS09325	COG2951	lytic endotransglycosylase activity
VCM66_RS09330	COG3100	YcgL domain-containing protein
VCM66_RS09335	COG0850	regulation of cytokinetic process
VCM66_RS09340	COG2894	cell division
VCM66_RS09345	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VCM66_RS09350	COG3015	lipoprotein NlpE involved in copper resistance
VCM66_RS09370	COG0477	Major facilitator Superfamily
VCM66_RS09380	COG0840	transmembrane signaling receptor activity
VCM66_RS09385	COG1396	sequence-specific DNA binding
VCM66_RS09390	COG3135	benzoate transporter
VCM66_RS09410	COG0596	Alpha beta hydrolase
VCM66_RS09415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VCM66_RS09420	COG1169	isochorismate synthase
VCM66_RS09425	COG0436	Aminotransferase
VCM66_RS09430	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VCM66_RS09435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCM66_RS09455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VCM66_RS09460	COG0318	PFAM AMP-dependent synthetase and ligase
VCM66_RS09465	COG0596	Alpha beta hydrolase
VCM66_RS09480	COG1214	PFAM Peptidase M22, glycoprotease
VCM66_RS09485	COG1199	ATP-dependent helicase activity
VCM66_RS09495	COG0788	formyltetrahydrofolate deformylase activity
VCM66_RS09500	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCM66_RS09500	COG1902	pentaerythritol trinitrate reductase activity
VCM66_RS09505	COG0616	signal peptide processing
VCM66_RS09510	COG0252	asparaginase activity
VCM66_RS09515	COG3139	Protein of unknown function (DUF1315)
VCM66_RS09525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_RS09530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCM66_RS09535	COG0676	glucose-6-phosphate 1-epimerase activity
VCM66_RS09545	COG2226	methyltransferase
VCM66_RS09560	COG0784	Response regulator, receiver
VCM66_RS09560	COG0835	chemotaxis
VCM66_RS09565	COG1940	carbohydrate kinase activity
VCM66_RS09575	COG4667	esterase of the alpha-beta hydrolase superfamily
VCM66_RS09590	COG0733	neurotransmitter:sodium symporter activity
VCM66_RS09595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCM66_RS09595	COG1263	PTS System
VCM66_RS09600	COG0084	hydrolase, TatD family'
VCM66_RS09610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VCM66_RS09615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VCM66_RS09620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCM66_RS09625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCM66_RS09630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VCM66_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
VCM66_RS09645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCM66_RS09650	COG0416	fatty acid biosynthetic process
VCM66_RS09655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VCM66_RS09660	COG1399	metal-binding, possibly nucleic acid-binding protein
VCM66_RS09665	COG0424	maF-like protein
VCM66_RS09670	COG0564	pseudouridine synthase activity
VCM66_RS09685	COG1530	ribonuclease E activity
VCM66_RS09690	COG0659	secondary active sulfate transmembrane transporter activity
VCM66_RS09700	COG1012	belongs to the aldehyde dehydrogenase family
VCM66_RS09700	COG1454	alcohol dehydrogenase
VCM66_RS09705	COG2095	MarC family integral membrane protein
VCM66_RS09710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCM66_RS09715	COG1757	Na H antiporter
VCM66_RS09725	COG3081	Nucleoid-associated protein
VCM66_RS09730	COG3082	Protein of unknown function (DUF1414)
VCM66_RS09735	COG3083	sulfuric ester hydrolase activity
VCM66_RS09750	COG0123	including yeast histone deacetylase and acetoin utilization protein
VCM66_RS09755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCM66_RS09760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VCM66_RS09780	COG2853	Lipoprotein
VCM66_RS09790	COG4235	cytochrome complex assembly
VCM66_RS09790	COG3088	subunit of a heme lyase
VCM66_RS09795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VCM66_RS09800	COG1138	Cytochrome C-type biogenesis protein
VCM66_RS09805	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VCM66_RS09815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCM66_RS09820	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCM66_RS09825	COG4133	protoheme IX ABC transporter activity
VCM66_RS09835	COG0835	chemotaxis
VCM66_RS09845	COG1192	Involved in chromosome partitioning
VCM66_RS09850	COG2201	protein-glutamate methylesterase activity
VCM66_RS09855	COG0784	Response regulator, receiver
VCM66_RS09855	COG0643	Histidine kinase
VCM66_RS09855	COG2198	Histidine kinase
VCM66_RS09860	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VCM66_RS09895	COG1025	Belongs to the peptidase M16 family
VCM66_RS09905	COG0018	arginyl-trna synthetase
VCM66_RS09925	COG1918	ferrous iron import across plasma membrane
VCM66_RS09930	COG4977	sequence-specific DNA binding
VCM66_RS09935	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VCM66_RS09940	COG1121	(ABC) transporter
VCM66_RS09945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VCM66_RS09955	COG0045	succinate-CoA ligase (ADP-forming) activity
VCM66_RS09960	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCM66_RS09965	COG0567	Dehydrogenase, E1 component
VCM66_RS09975	COG1053	succinate dehydrogenase
VCM66_RS09980	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VCM66_RS09985	COG2009	succinate dehydrogenase
VCM66_RS09990	COG0372	Belongs to the citrate synthase family
VCM66_RS09995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VCM66_RS10005	COG0033	Phosphoglucomutase
VCM66_RS10010	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VCM66_RS10015	COG0596	Alpha beta hydrolase
VCM66_RS10030	COG1346	cytolysis
VCM66_RS10040	COG0583	DNA-binding transcription factor activity
VCM66_RS10050	COG0735	belongs to the Fur family
VCM66_RS10055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCM66_RS10060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCM66_RS10065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCM66_RS10075	COG0431	NADPH-dependent FMN reductase
VCM66_RS10085	COG3101	peptidyl-lysine hydroxylation
VCM66_RS10090	COG2860	membrane
VCM66_RS10095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VCM66_RS10105	COG2890	protein-(glutamine-N5) methyltransferase activity
VCM66_RS10110	COG2840	Smr protein MutS2
VCM66_RS10120	COG1684	flagellar biosynthetic protein fliR
VCM66_RS10125	COG1987	bacterial-type flagellum assembly
VCM66_RS10150	COG1580	Controls the rotational direction of flagella during chemotaxis
VCM66_RS10170	COG1317	bacterial-type flagellum organization
VCM66_RS10175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VCM66_RS10185	COG1677	Flagellar hook-basal body complex protein FliE
VCM66_RS10205	COG1516	flagellar protein fliS
VCM66_RS10215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VCM66_RS10220	COG1334	flagellar protein FlaG
VCM66_RS10225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_RS10230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_RS10235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_RS10240	COG2837	iron assimilation
VCM66_RS10260	COG1393	Belongs to the ArsC family
VCM66_RS10270	COG1876	peptidase activity
VCM66_RS10280	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VCM66_RS10295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VCM66_RS10315	COG4783	chaperone-mediated protein folding
VCM66_RS10320	COG1393	Belongs to the ArsC family
VCM66_RS10340	COG2233	PERMEase
VCM66_RS10345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VCM66_RS10350	COG0737	Belongs to the 5'-nucleotidase family
VCM66_RS10355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VCM66_RS10360	COG2912	Transglutaminase-like superfamily
VCM66_RS10370	COG2890	protein-(glutamine-N5) methyltransferase activity
VCM66_RS10375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VCM66_RS10380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VCM66_RS10385	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VCM66_RS10390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VCM66_RS10395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VCM66_RS10400	COG0193	aminoacyl-tRNA hydrolase activity
VCM66_RS10405	COG0012	GTP binding
VCM66_RS10490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_RS10495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCM66_RS10515	COG1705	Flagellar rod assembly protein muramidase FlgJ
VCM66_RS10515	COG3951	Flagellar rod assembly protein muramidase FlgJ
VCM66_RS10520	COG1706	bacterial-type flagellum-dependent cell motility
VCM66_RS10525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VCM66_RS10535	COG4787	bacterial-type flagellum-dependent cell motility
VCM66_RS10540	COG1749	Flagellar hook protein flgE
VCM66_RS10555	COG1815	bacterial-type flagellum-dependent cell motility
VCM66_RS10560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCM66_RS10565	COG0784	Response regulator, receiver
VCM66_RS10565	COG0835	chemotaxis
VCM66_RS10600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCM66_RS10600	COG2226	methyltransferase
VCM66_RS10600	COG3433	isochorismatase activity
VCM66_RS10605	COG2375	cellular response to nickel ion
VCM66_RS10610	COG1629	transport
VCM66_RS10610	COG4774	siderophore transport
VCM66_RS10625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCM66_RS10630	COG2608	mercury ion transmembrane transporter activity
VCM66_RS10630	COG2217	Heavy metal translocating P-type atpase
VCM66_RS10645	COG3735	TraB family
VCM66_RS10660	COG2840	Smr protein MutS2
VCM66_RS10665	COG1187	pseudouridine synthase activity
VCM66_RS10675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VCM66_RS10680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VCM66_RS10685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VCM66_RS10690	COG0121	glutamine amidotransferase
VCM66_RS10695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCM66_RS10700	COG1960	acyl-CoA dehydrogenase activity
VCM66_RS10715	COG0328	RNA-DNA hybrid ribonuclease activity
VCM66_RS10720	COG2226	methyltransferase
VCM66_RS10725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCM66_RS10730	COG0741	lytic transglycosylase activity
VCM66_RS10730	COG1388	LysM domain
VCM66_RS10735	COG3021	interspecies interaction between organisms
VCM66_RS10740	COG0347	Belongs to the P(II) protein family
VCM66_RS10745	COG3479	Phenolic acid decarboxylase
VCM66_RS10755	COG0037	tRNA processing
VCM66_RS10760	COG0825	malonyl-CoA metabolic process
VCM66_RS10765	COG0587	DNA-directed DNA polymerase activity
VCM66_RS10770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VCM66_RS10775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_RS10780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_RS10785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCM66_RS10790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCM66_RS10795	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VCM66_RS10805	COG0750	zinc metalloprotease
VCM66_RS10810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VCM66_RS10815	COG0575	Belongs to the CDS family
VCM66_RS10820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VCM66_RS10825	COG0233	cytoplasmic translational termination
VCM66_RS10830	COG0528	UMP kinase activity
VCM66_RS10835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VCM66_RS10840	COG0052	Belongs to the universal ribosomal protein uS2 family
VCM66_RS10845	COG0024	Methionine aminopeptidase
VCM66_RS10850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VCM66_RS10860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VCM66_RS10865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VCM66_RS10870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCM66_RS10875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VCM66_RS10890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCM66_RS10890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCM66_RS10895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VCM66_RS10900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VCM66_RS10905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VCM66_RS10915	COG1073	alpha beta
VCM66_RS10920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VCM66_RS10925	COG2252	PERMEase
VCM66_RS10930	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCM66_RS10935	COG0189	ligase activity
VCM66_RS10935	COG4067	protein conserved in archaea
VCM66_RS10940	COG0189	ligase activity
VCM66_RS10950	COG0733	neurotransmitter:sodium symporter activity
VCM66_RS10955	COG3706	GGDEF domain
VCM66_RS10975	COG1477	protein flavinylation
VCM66_RS10980	COG2871	sodium ion transport
VCM66_RS10985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_RS10990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_RS10995	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_RS11000	COG1805	sodium ion transport
VCM66_RS11005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCM66_RS11010	COG0271	Belongs to the BolA IbaG family
VCM66_RS11015	COG2813	Specifically methylates the guanine in position
VCM66_RS11025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCM66_RS11030	COG2211	Major facilitator Superfamily
VCM66_RS11040	COG1595	DNA-templated transcription, initiation
VCM66_RS11050	COG3248	Nucleoside-binding outer membrane protein
VCM66_RS11055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VCM66_RS11060	COG0693	protein deglycase activity
VCM66_RS11065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCM66_RS11070	COG2166	iron-sulfur cluster assembly
VCM66_RS11075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VCM66_RS11080	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VCM66_RS11090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCM66_RS11090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCM66_RS11105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VCM66_RS11110	COG1074	ATP-dependent DNA helicase activity
VCM66_RS11115	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VCM66_RS11130	COG3141	response to X-ray
VCM66_RS11135	COG2171	N-acyltransferase activity
VCM66_RS11145	COG0456	acetyltransferase
VCM66_RS11150	COG0189	ligase activity
VCM66_RS11150	COG0569	domain protein
VCM66_RS11165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCM66_RS11170	COG1609	Transcriptional regulator
VCM66_RS11175	COG3250	beta-galactosidase activity
VCM66_RS11190	COG1022	Amp-dependent synthetase and ligase
VCM66_RS11195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCM66_RS11200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VCM66_RS11210	COG0560	Phosphoserine phosphatase
VCM66_RS11220	COG0813	purine-nucleoside phosphorylase activity
VCM66_RS11225	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VCM66_RS11230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VCM66_RS11235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VCM66_RS11245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCM66_RS11250	COG0084	hydrolase, TatD family'
VCM66_RS11255	COG3022	response to hydroperoxide
VCM66_RS11260	COG1115	amino acid carrier protein
VCM66_RS11275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VCM66_RS11280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VCM66_RS11285	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VCM66_RS11290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VCM66_RS11310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCM66_RS11320	COG0745	RESPONSE REGULATOR receiver
VCM66_RS11325	COG2198	Histidine kinase
VCM66_RS11325	COG5002	protein histidine kinase activity
VCM66_RS11325	COG0784	Response regulator, receiver
VCM66_RS11330	COG3706	GGDEF domain
VCM66_RS11330	COG2203	Gaf domain
VCM66_RS11330	COG5001	Diguanylate cyclase
VCM66_RS11330	COG4251	negative regulation of phosphorylation
VCM66_RS11335	COG1242	4 iron, 4 sulfur cluster binding
VCM66_RS11340	COG0070	glutamate synthase
VCM66_RS11340	COG0069	glutamate synthase activity
VCM66_RS11340	COG0067	glutamate synthase
VCM66_RS11350	COG0069	glutamate synthase activity
VCM66_RS11350	COG0070	glutamate synthase
VCM66_RS11350	COG0067	glutamate synthase
VCM66_RS11355	COG0493	'glutamate synthase
VCM66_RS11365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VCM66_RS11375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCM66_RS11380	COG2860	membrane
VCM66_RS11385	COG0583	DNA-binding transcription factor activity
VCM66_RS11390	COG0730	response to heat
VCM66_RS11420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCM66_RS11425	COG0505	Belongs to the CarA family
VCM66_RS11435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VCM66_RS11440	COG0494	nUDIX hydrolase
VCM66_RS11450	COG0653	protein targeting
VCM66_RS11460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VCM66_RS11465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VCM66_RS11470	COG0849	cell division
VCM66_RS11475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VCM66_RS11480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCM66_RS11490	COG0772	Belongs to the SEDS family
VCM66_RS11495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VCM66_RS11505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VCM66_RS11510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VCM66_RS11515	COG0768	penicillin binding
VCM66_RS11520	COG3116	cell division
VCM66_RS11530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_RS11535	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCM66_RS11540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VCM66_RS11545	COG2186	Transcriptional regulator
VCM66_RS11550	COG0737	Belongs to the 5'-nucleotidase family
VCM66_RS11555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VCM66_RS11560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCM66_RS11565	COG4974	Belongs to the 'phage' integrase family
VCM66_RS11570	COG0716	FMN binding
VCM66_RS11590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_RS11595	COG1459	type II secretion system
VCM66_RS11605	COG0237	dephospho-CoA kinase activity
VCM66_RS11610	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VCM66_RS11620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VCM66_RS11625	COG0187	DNA topoisomerase II activity
VCM66_RS11630	COG3150	esterase
VCM66_RS11640	COG3151	Protein conserved in bacteria
VCM66_RS11645	COG0494	nUDIX hydrolase
VCM66_RS11650	COG1538	Outer membrane efflux protein
VCM66_RS11660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VCM66_RS11665	COG0840	transmembrane signaling receptor activity
VCM66_RS11670	COG3025	triphosphatase activity
VCM66_RS11675	COG1392	Phosphate transport regulator
VCM66_RS11680	COG0306	phosphate transporter
VCM66_RS11685	COG4991	sh3 domain protein
VCM66_RS11695	COG3267	Type II secretory pathway component ExeA
VCM66_RS11695	COG3409	Peptidoglycan-binding domain 1 protein
VCM66_RS11705	COG0148	phosphopyruvate hydratase activity
VCM66_RS11710	COG0504	CTP synthase activity
VCM66_RS11715	COG3956	TIGRFAM MazG family protein
VCM66_RS11720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCM66_RS11735	COG5001	Diguanylate cyclase
VCM66_RS11755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VCM66_RS11760	COG1381	Involved in DNA repair and RecF pathway recombination
VCM66_RS11765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VCM66_RS11780	COG0481	GTPase activity
VCM66_RS11785	COG3086	response to oxidative stress
VCM66_RS11800	COG1595	DNA-templated transcription, initiation
VCM66_RS11810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VCM66_RS11820	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VCM66_RS11835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_RS11840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCM66_RS11845	COG3079	Belongs to the UPF0149 family
VCM66_RS11850	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VCM66_RS11855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VCM66_RS11860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VCM66_RS11865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCM66_RS11870	COG0440	acetolactate synthase activity
VCM66_RS11875	COG0028	Belongs to the TPP enzyme family
VCM66_RS11880	COG1022	Amp-dependent synthetase and ligase
VCM66_RS11885	COG0583	DNA-binding transcription factor activity
VCM66_RS11910	COG0473	3-isopropylmalate dehydrogenase activity
VCM66_RS11915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VCM66_RS11920	COG0066	3-isopropylmalate dehydratase activity
VCM66_RS11965	COG3437	response regulator, receiver
VCM66_RS11980	COG0795	lipopolysaccharide-transporting ATPase activity
VCM66_RS11985	COG0795	lipopolysaccharide-transporting ATPase activity
VCM66_RS11990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCM66_RS11995	COG2927	DNA polymerase III (CHI subunit)
VCM66_RS12000	COG0525	valine-tRNA ligase activity
VCM66_RS12005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCM66_RS12010	COG0564	pseudouridine synthase activity
VCM66_RS12025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VCM66_RS12040	COG0540	Belongs to the ATCase OTCase family
VCM66_RS12050	COG0251	oxidation-reduction process
VCM66_RS12060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VCM66_RS12065	COG5007	Belongs to the BolA IbaG family
VCM66_RS12075	COG2854	intermembrane phospholipid transfer
VCM66_RS12080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCM66_RS12085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VCM66_RS12090	COG1127	ABC transporter
VCM66_RS12105	COG0517	IMP dehydrogenase activity
VCM66_RS12105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VCM66_RS12120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VCM66_RS12125	COG1137	ATPase activity
VCM66_RS12135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCM66_RS12140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_RS12145	COG1660	Displays ATPase and GTPase activities
VCM66_RS12150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCM66_RS12155	COG2239	Acts as a magnesium transporter
VCM66_RS12160	COG0312	modulator of DNA gyrase
VCM66_RS12165	COG3028	Belongs to the UPF0307 family
VCM66_RS12170	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VCM66_RS12175	COG1178	ABC-type Fe3 transport system permease component
VCM66_RS12185	COG0163	prenyltransferase activity
VCM66_RS12190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCM66_RS12205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VCM66_RS12210	COG2105	PFAM AIG2 family protein
VCM66_RS12220	COG0729	surface antigen
VCM66_RS12225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCM66_RS12230	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VCM66_RS12245	COG1136	(ABC) transporter
VCM66_RS12265	COG0529	Catalyzes the synthesis of activated sulfate
VCM66_RS12280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCM66_RS12280	COG1648	precorrin-2 dehydrogenase activity
VCM66_RS12285	COG0737	Belongs to the 5'-nucleotidase family
VCM66_RS12295	COG0513	Belongs to the DEAD box helicase family
VCM66_RS12300	COG2153	protein acetylation
VCM66_RS12305	COG0697	spore germination
VCM66_RS12310	COG3061	Opacity-associated protein A
VCM66_RS12310	COG3266	domain, Protein
VCM66_RS12315	COG0545	Peptidyl-prolyl cis-trans isomerase
VCM66_RS12325	COG0203	ribosomal protein L17
VCM66_RS12330	COG0202	RNA polymerase activity
VCM66_RS12335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VCM66_RS12340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VCM66_RS12345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VCM66_RS12350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCM66_RS12355	COG0201	protein transport
VCM66_RS12365	COG1841	ribosomal large subunit assembly
VCM66_RS12370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VCM66_RS12375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VCM66_RS12385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VCM66_RS12390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VCM66_RS12395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VCM66_RS12400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VCM66_RS12405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VCM66_RS12410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VCM66_RS12415	COG0255	Belongs to the universal ribosomal protein uL29 family
VCM66_RS12420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VCM66_RS12425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VCM66_RS12430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VCM66_RS12435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VCM66_RS12440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VCM66_RS12445	COG0089	rRNA binding
VCM66_RS12450	COG0088	Forms part of the polypeptide exit tunnel
VCM66_RS12455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VCM66_RS12460	COG0051	transcription antitermination factor activity, RNA binding
VCM66_RS12465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCM66_RS12470	COG0557	exoribonuclease II activity
VCM66_RS12475	COG3083	sulfuric ester hydrolase activity
VCM66_RS12480	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VCM66_RS12495	COG1047	Peptidyl-prolyl cis-trans
VCM66_RS12510	COG2249	NAD(P)H dehydrogenase (quinone) activity
VCM66_RS12515	COG0488	(ABC) transporter
VCM66_RS12525	COG0429	hydrolase of the alpha beta-hydrolase fold
VCM66_RS12535	COG3954	Phosphoribulokinase
VCM66_RS12560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VCM66_RS12570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCM66_RS12585	COG0180	Tryptophanyl-tRNA synthetase
VCM66_RS12590	COG0546	phosphoglycolate phosphatase activity
VCM66_RS12595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VCM66_RS12600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VCM66_RS12610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VCM66_RS12615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VCM66_RS12645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VCM66_RS12655	COG0678	peroxiredoxin activity
VCM66_RS12655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCM66_RS12660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCM66_RS12670	COG0165	Argininosuccinate lyase
VCM66_RS12675	COG0137	argininosuccinate synthase activity
VCM66_RS12680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCM66_RS12685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VCM66_RS12690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCM66_RS12695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VCM66_RS12705	COG1045	serine acetyltransferase
VCM66_RS12710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VCM66_RS12715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VCM66_RS12720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCM66_RS12725	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VCM66_RS12730	COG1053	succinate dehydrogenase
VCM66_RS12735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VCM66_RS12740	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VCM66_RS12750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCM66_RS12755	COG1509	lysine 2,3-aminomutase activity
VCM66_RS12765	COG0459	protein refolding
VCM66_RS12770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VCM66_RS12795	COG0149	triose-phosphate isomerase activity
VCM66_RS12800	COG0534	Mate efflux family protein
VCM66_RS12805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCM66_RS12810	COG1575	Belongs to the MenA family. Type 1 subfamily
VCM66_RS12820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VCM66_RS12825	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCM66_RS12830	COG1609	Transcriptional regulator
VCM66_RS12835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VCM66_RS12840	COG0254	rRNA binding
VCM66_RS12845	COG0281	malic enzyme
VCM66_RS12850	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VCM66_RS12855	COG0626	cystathionine gamma-synthase activity
VCM66_RS12860	COG0460	homoserine dehydrogenase
VCM66_RS12860	COG0527	aspartate kinase activity
VCM66_RS12865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VCM66_RS12870	COG3074	FtsZ-dependent cytokinesis
VCM66_RS12875	COG1494	fructose-1,6-bisphosphatase
VCM66_RS12880	COG0205	6-phosphofructokinase activity
VCM66_RS12885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VCM66_RS12895	COG0745	RESPONSE REGULATOR receiver
VCM66_RS12900	COG2205	protein histidine kinase activity
VCM66_RS12910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VCM66_RS12915	COG3030	protein affecting phage T7 exclusion by the F plasmid
VCM66_RS12920	COG3706	GGDEF domain
VCM66_RS12925	COG1027	Aspartate ammonia-lyase
VCM66_RS12930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCM66_RS12945	COG4232	protein-disulfide reductase activity
VCM66_RS12965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCM66_RS12970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VCM66_RS12975	COG0194	GDP metabolic process
VCM66_RS12980	COG1758	RNA polymerase activity
VCM66_RS12985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCM66_RS12990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VCM66_RS12995	COG2233	PERMEase
VCM66_RS13010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCM66_RS13015	COG2183	response to ionizing radiation
VCM66_RS13025	COG0596	Alpha beta hydrolase
VCM66_RS13030	COG1040	competence protein
VCM66_RS13040	COG0494	nUDIX hydrolase
VCM66_RS13045	COG1218	3'(2'),5'-bisphosphate nucleotidase
VCM66_RS13055	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCM66_RS13060	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCM66_RS13065	COG3156	type II secretion system protein K
VCM66_RS13070	COG4795	General secretion pathway protein
VCM66_RS13075	COG2165	general secretion pathway protein
VCM66_RS13080	COG2165	general secretion pathway protein
VCM66_RS13085	COG2165	general secretion pathway protein
VCM66_RS13090	COG1459	type II secretion system
VCM66_RS13095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_RS13105	COG3031	protein transport across the cell outer membrane
VCM66_RS13110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VCM66_RS13115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VCM66_RS13120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VCM66_RS13130	COG0456	acetyltransferase
VCM66_RS13135	COG1490	D-aminoacyl-tRNA deacylase activity
VCM66_RS13140	COG1295	ribonuclease BN
VCM66_RS13150	COG1217	gtp-binding protein TYPA
VCM66_RS13160	COG0174	glutamine synthetase
VCM66_RS13170	COG3852	Histidine kinase
VCM66_RS13180	COG3300	MHYT domain
VCM66_RS13180	COG5001	Diguanylate cyclase
VCM66_RS13185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCM66_RS13230	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VCM66_RS13235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCM66_RS13240	COG1739	Uncharacterized protein family UPF0029
VCM66_RS13250	COG0183	Belongs to the thiolase family
VCM66_RS13255	COG0583	DNA-binding transcription factor activity
VCM66_RS13260	COG2814	Major facilitator Superfamily
VCM66_RS13270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VCM66_RS13275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VCM66_RS13280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VCM66_RS13285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VCM66_RS13290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VCM66_RS13295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VCM66_RS13305	COG0356	it plays a direct role in the translocation of protons across the membrane
VCM66_RS13310	COG3312	ion transport
VCM66_RS13315	COG1475	DNA binding
VCM66_RS13320	COG1192	Involved in chromosome partitioning
VCM66_RS13330	COG0445	tRNA wobble uridine modification
VCM66_RS13345	COG0706	membrane insertase activity
VCM66_RS13375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VCM66_RS13765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_RS13765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCM66_RS13820	COG3072	Adenylate cyclase
VCM66_RS13995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VCM66_RS14185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCM66_RS14475	COG3710	Transcriptional regulator
VCM66_RS14530	COG2610	gluconate transmembrane transporter activity
VCM66_RS14535	COG2610	gluconate transmembrane transporter activity
VCM66_RS14655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VCM66_RS14785	COG0085	RNA polymerase activity
VCM66_RS14795	COG0085	RNA polymerase activity
VCM66_RS14815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VCM66_RS14850	COG2816	NAD+ diphosphatase activity
VCM66_RS14870	COG4942	peptidase
VCM66_RS14930	COG1162	GTPase activity
VCM66_RS14970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VCM66_RS15050	COG0330	HflC and HflK could
VCM66_RS15105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCM66_RS15165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCM66_RS15225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCM66_RS15325	COG1410	methionine synthase
VCM66_RS15325	COG0646	methionine synthase
VCM66_RS15345	COG1410	methionine synthase
VCM66_RS15345	COG0646	methionine synthase
VCM66_RS15370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCM66_RS15450	COG2200	EAL domain
VCM66_RS15450	COG2199	diguanylate cyclase activity
VCM66_RS15475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCM66_RS15640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCM66_RS15745	COG0189	ligase activity
VCM66_RS15925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VCM66_RS15950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VCM66_RS16040	COG0612	Peptidase, M16
VCM66_RS16070	COG4137	Cytochrome C assembly protein
VCM66_RS16080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VCM66_RS16105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCM66_RS16235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCM66_RS16245	COG1752	Esterase of the alpha-beta hydrolase superfamily
VCM66_RS16830	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCM66_RS16900	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VCM66_RS17110	COG1021	2,3-dihydroxybenzoate-AMP ligase
VCM66_RS17255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCM66_RS17430	COG1459	type II secretion system
VCM66_RS17485	COG3064	Membrane
VCM66_RS17495	COG3064	Membrane
VCM66_RS17615	COG0047	phosphoribosylformylglycinamidine synthase activity
VCM66_RS17615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCM66_RS17625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCM66_RS17625	COG0047	phosphoribosylformylglycinamidine synthase activity
VCM66_RS17790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCM66_RS17795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCM66_RS17940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VCM66_RS18000	COG0495	leucyl-tRNA aminoacylation
VCM66_RS18110	COG0326	Molecular chaperone. Has ATPase activity
VCM66_RS18125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX