locus-tag	class	description
VCD_RS00010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VCD_RS00015	COG0842	Transport permease protein
VCD_RS00020	COG1131	(ABC) transporter
VCD_RS00025	COG0659	secondary active sulfate transmembrane transporter activity
VCD_RS00030	COG0288	reversible hydration of carbon dioxide
VCD_RS00045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VCD_RS00050	COG3107	peptidoglycan biosynthetic process
VCD_RS00055	COG0792	nuclease activity
VCD_RS00060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCD_RS00065	COG2823	Periplasmic or secreted lipoprotein
VCD_RS00070	COG2969	positive regulation of protein catabolic process
VCD_RS00075	COG0625	glutathione transferase activity
VCD_RS00080	COG2857	Cytochrome c1
VCD_RS00085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VCD_RS00090	COG0723	plastoquinol--plastocyanin reductase activity
VCD_RS00095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VCD_RS00100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VCD_RS00110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VCD_RS00120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCD_RS00125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCD_RS00130	COG0335	large ribosomal subunit rRNA binding
VCD_RS00135	COG0336	Belongs to the RNA methyltransferase TrmD family
VCD_RS00140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VCD_RS00145	COG0228	four-way junction DNA binding
VCD_RS00150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VCD_RS00155	COG4137	Cytochrome C assembly protein
VCD_RS00160	COG4536	flavin adenine dinucleotide binding
VCD_RS00165	COG1854	S-ribosylhomocysteine lyase activity
VCD_RS00170	COG2918	glutathione biosynthetic process
VCD_RS00175	COG0612	Peptidase, M16
VCD_RS00180	COG1238	metal cluster binding
VCD_RS00190	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCD_RS00195	COG5016	pyruvate
VCD_RS00195	COG0511	ligase activity, forming carbon-carbon bonds
VCD_RS00200	COG3630	sodium ion export across plasma membrane
VCD_RS00245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VCD_RS00250	COG0527	aspartate kinase activity
VCD_RS00255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VCD_RS00265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VCD_RS00275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VCD_RS00280	COG4208	sulfate ABC transporter
VCD_RS00300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VCD_RS00305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCD_RS00315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VCD_RS00320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VCD_RS00325	COG0585	pseudouridine synthase activity
VCD_RS00330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VCD_RS00335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VCD_RS00340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VCD_RS00345	COG1968	undecaprenyl-diphosphatase activity
VCD_RS00350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCD_RS00355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VCD_RS00360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VCD_RS00370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VCD_RS00375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VCD_RS00380	COG1610	YqeY-like protein
VCD_RS00385	COG0358	DNA primase activity
VCD_RS00400	COG0582	viral genome integration into host DNA
VCD_RS00405	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCD_RS00415	COG2207	Transcriptional regulator
VCD_RS00420	COG0840	transmembrane signaling receptor activity
VCD_RS00430	COG2003	Belongs to the UPF0758 family
VCD_RS00465	COG0739	heme binding
VCD_RS00470	COG4969	Belongs to the N-Me-Phe pilin family
VCD_RS00490	COG0328	RNA-DNA hybrid ribonuclease activity
VCD_RS00540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCD_RS00545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VCD_RS00550	COG1349	DNA-binding transcription factor activity
VCD_RS00570	COG1279	arginine transmembrane transporter activity
VCD_RS00575	COG0668	transmembrane transport
VCD_RS00585	COG0191	fructose-bisphosphate aldolase activity
VCD_RS00590	COG0126	phosphoglycerate kinase activity
VCD_RS00595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCD_RS00600	COG4771	TonB-dependent receptor
VCD_RS00605	COG0583	DNA-binding transcription factor activity
VCD_RS00610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCD_RS00620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VCD_RS00630	COG2356	endonuclease I
VCD_RS00635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VCD_RS00640	COG0189	ligase activity
VCD_RS00645	COG1678	Uncharacterized ACR, COG1678
VCD_RS00650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VCD_RS00655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCD_RS00675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VCD_RS00680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VCD_RS00685	COG0762	integral membrane protein
VCD_RS00690	COG1872	DUF167
VCD_RS00700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VCD_RS00705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCD_RS00710	COG2066	Belongs to the glutaminase family
VCD_RS00720	COG1194	a g-specific adenine glycosylase
VCD_RS00725	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VCD_RS00730	COG0741	lytic transglycosylase activity
VCD_RS00755	COG0840	transmembrane signaling receptor activity
VCD_RS00785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCD_RS00790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCD_RS00795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCD_RS00800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VCD_RS00805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VCD_RS00810	COG2967	ApaG domain
VCD_RS00815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VCD_RS00825	COG3610	response to peptide
VCD_RS00830	COG2966	Psort location CytoplasmicMembrane, score
VCD_RS00835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VCD_RS00840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VCD_RS00845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VCD_RS00850	COG0142	geranyltranstransferase activity
VCD_RS00855	COG0531	amino acid
VCD_RS00860	COG0531	amino acid
VCD_RS00865	COG0039	L-malate dehydrogenase activity
VCD_RS00870	COG1438	arginine binding
VCD_RS00875	COG2358	TRAP transporter, solute receptor (TAXI family
VCD_RS00885	COG0589	response to stress
VCD_RS00910	COG3550	peptidyl-serine autophosphorylation
VCD_RS00925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_RS00935	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_RS00985	COG2235	arginine
VCD_RS00990	COG0312	modulator of DNA gyrase
VCD_RS00995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCD_RS01000	COG3164	Protein of unknown function
VCD_RS01010	COG0424	maF-like protein
VCD_RS01015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VCD_RS01020	COG1792	Involved in formation and maintenance of cell shape
VCD_RS01025	COG1077	Cell shape determining protein MreB Mrl
VCD_RS01055	COG2165	general secretion pathway protein
VCD_RS01060	COG2165	general secretion pathway protein
VCD_RS01070	COG1459	type II secretion system
VCD_RS01075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_RS01085	COG3267	Type II secretory pathway component ExeA
VCD_RS01085	COG3409	Peptidoglycan-binding domain 1 protein
VCD_RS01110	COG2199	diguanylate cyclase activity
VCD_RS01110	COG2200	EAL domain
VCD_RS01115	COG0629	single-stranded DNA binding
VCD_RS01130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VCD_RS01140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCD_RS01145	COG0527	aspartate kinase activity
VCD_RS01150	COG1410	methionine synthase
VCD_RS01150	COG0646	methionine synthase
VCD_RS01195	COG0175	sulfate reduction
VCD_RS01205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCD_RS01230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCD_RS01235	COG0735	belongs to the Fur family
VCD_RS01255	COG0432	Pfam Uncharacterised protein family UPF0047
VCD_RS01260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCD_RS01275	COG0359	binds to the 23S rRNA
VCD_RS01280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VCD_RS01285	COG2965	DNA replication, synthesis of RNA primer
VCD_RS01290	COG0360	Binds together with S18 to 16S ribosomal RNA
VCD_RS01300	COG2906	2 iron, 2 sulfur cluster binding
VCD_RS01305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCD_RS01310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCD_RS01315	COG0049	tRNA binding
VCD_RS01330	COG2923	Belongs to the DsrF TusC family
VCD_RS01335	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VCD_RS01340	COG2964	Protein conserved in bacteria
VCD_RS01345	COG0545	Peptidyl-prolyl cis-trans isomerase
VCD_RS01355	COG2900	Belongs to the SlyX family
VCD_RS01360	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VCD_RS01365	COG0330	HflC and HflK could
VCD_RS01370	COG0330	HflC and HflK could
VCD_RS01375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCD_RS01380	COG1923	regulation of RNA biosynthetic process
VCD_RS01385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VCD_RS01390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VCD_RS01400	COG0802	atpase or kinase
VCD_RS01405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VCD_RS01450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VCD_RS01455	COG1162	GTPase activity
VCD_RS01460	COG0688	phosphatidylethanolamine metabolic process
VCD_RS01465	COG0471	metal ion transport
VCD_RS01475	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VCD_RS01480	COG4942	peptidase
VCD_RS01495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VCD_RS01500	COG2816	NAD+ diphosphatase activity
VCD_RS01505	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VCD_RS01510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VCD_RS01515	COG0085	RNA polymerase activity
VCD_RS01520	COG0222	ribosome binding
VCD_RS01525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VCD_RS01535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VCD_RS01540	COG0250	Participates in transcription elongation, termination and antitermination
VCD_RS01545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCD_RS01550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCD_RS01575	COG1072	(Pantothenic acid kinase))
VCD_RS01585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VCD_RS01600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VCD_RS01645	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VCD_RS01660	COG3118	belongs to the thioredoxin family
VCD_RS01665	COG0513	Belongs to the DEAD box helicase family
VCD_RS01670	COG0248	Ppx GppA phosphatase
VCD_RS01675	COG0784	Response regulator, receiver
VCD_RS01675	COG2205	protein histidine kinase activity
VCD_RS01680	COG2814	Major facilitator Superfamily
VCD_RS01700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCD_RS01705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VCD_RS01710	COG0511	ligase activity, forming carbon-carbon bonds
VCD_RS01715	COG0439	Biotin carboxylase
VCD_RS01720	COG2264	protein methyltransferase activity
VCD_RS01725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCD_RS01730	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VCD_RS01735	COG1609	Transcriptional regulator
VCD_RS01740	COG0129	dihydroxy-acid dehydratase activity
VCD_RS01745	COG3265	gluconokinase activity
VCD_RS01755	COG0800	Aldolase
VCD_RS01775	COG0840	transmembrane signaling receptor activity
VCD_RS01780	COG1982	Orn Lys Arg decarboxylase major
VCD_RS01785	COG0531	amino acid
VCD_RS01790	COG3710	Transcriptional regulator
VCD_RS01795	COG0789	Transcriptional regulator
VCD_RS01805	COG0151	Belongs to the GarS family
VCD_RS01815	COG0776	regulation of translation
VCD_RS01825	COG1253	flavin adenine dinucleotide binding
VCD_RS01830	COG1940	carbohydrate kinase activity
VCD_RS01840	COG3068	Protein conserved in bacteria
VCD_RS01850	COG1573	uracil-dna glycosylase
VCD_RS01855	COG0668	transmembrane transport
VCD_RS01860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VCD_RS01865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCD_RS01895	COG5433	transposase activity
VCD_RS01910	COG1454	alcohol dehydrogenase
VCD_RS01910	COG1012	belongs to the aldehyde dehydrogenase family
VCD_RS01915	COG0318	PFAM AMP-dependent synthetase and ligase
VCD_RS01945	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VCD_RS01950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCD_RS01955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VCD_RS01955	COG0662	Cupin 2, conserved barrel domain protein
VCD_RS01960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCD_RS01995	COG1519	Transferase
VCD_RS02025	COG3642	lipopolysaccharide core region biosynthetic process
VCD_RS02030	COG0859	PFAM glycosyl transferase family 9
VCD_RS02035	COG0463	Glycosyl transferase, family 2
VCD_RS02040	COG0859	PFAM glycosyl transferase family 9
VCD_RS02045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VCD_RS02050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VCD_RS02060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VCD_RS02065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VCD_RS02070	COG2003	Belongs to the UPF0758 family
VCD_RS02075	COG0840	transmembrane signaling receptor activity
VCD_RS02080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VCD_RS02085	COG1309	transcriptional regulator
VCD_RS02090	COG1560	Kdo2-lipid A biosynthetic process
VCD_RS02095	COG1560	Kdo2-lipid A biosynthetic process
VCD_RS02100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VCD_RS02105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCD_RS02110	COG1561	YicC-like family, N-terminal region
VCD_RS02115	COG2862	Uncharacterized protein family, UPF0114
VCD_RS02120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_RS02120	COG1263	PTS System
VCD_RS02125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCD_RS02150	COG1120	ATPase activity
VCD_RS02155	COG4774	siderophore transport
VCD_RS02160	COG1132	(ABC) transporter
VCD_RS02175	COG0514	ATP-dependent DNA helicase (RecQ)
VCD_RS02180	COG2962	Rard protein
VCD_RS02195	COG1280	lysine exporter protein (LysE YggA)
VCD_RS02200	COG0210	DNA helicase
VCD_RS02210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VCD_RS02215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_RS02255	COG3621	Patatin-like phospholipase
VCD_RS02280	COG2131	deaminase
VCD_RS02290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCD_RS02295	COG0601	transmembrane transport
VCD_RS02300	COG0747	negative chemotaxis
VCD_RS02355	COG1309	transcriptional regulator
VCD_RS02360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_RS02365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCD_RS02370	COG2960	long-chain fatty acid transporting porin activity
VCD_RS02375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VCD_RS02380	COG0583	DNA-binding transcription factor activity
VCD_RS02425	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VCD_RS02430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCD_RS02435	COG1739	Uncharacterized protein family UPF0029
VCD_RS02445	COG0183	Belongs to the thiolase family
VCD_RS02450	COG0583	DNA-binding transcription factor activity
VCD_RS02455	COG2814	Major facilitator Superfamily
VCD_RS02460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VCD_RS02465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VCD_RS02470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VCD_RS02475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VCD_RS02480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VCD_RS02485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VCD_RS02490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VCD_RS02500	COG0356	it plays a direct role in the translocation of protons across the membrane
VCD_RS02505	COG3312	ion transport
VCD_RS02510	COG1475	DNA binding
VCD_RS02515	COG1192	Involved in chromosome partitioning
VCD_RS02525	COG0445	tRNA wobble uridine modification
VCD_RS02535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCD_RS02540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VCD_RS02545	COG0706	membrane insertase activity
VCD_RS02555	COG0594	ribonuclease P activity
VCD_RS02560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VCD_RS02565	COG1126	abc transporter atp-binding protein
VCD_RS02580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VCD_RS02585	COG0592	DNA-directed DNA polymerase activity
VCD_RS02590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VCD_RS02595	COG0187	DNA topoisomerase II activity
VCD_RS02610	COG0071	Belongs to the small heat shock protein (HSP20) family
VCD_RS02615	COG3977	Valine--pyruvate aminotransferase
VCD_RS02620	COG0751	glycine-tRNA ligase activity
VCD_RS02625	COG0752	glycyl-tRNA synthetase alpha subunit
VCD_RS02630	COG2119	membrane
VCD_RS02640	COG0425	Belongs to the sulfur carrier protein TusA family
VCD_RS02650	COG0604	alcohol dehydrogenase
VCD_RS02660	COG0129	dihydroxy-acid dehydratase activity
VCD_RS02665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCD_RS02680	COG0606	chelatase, subunit chli
VCD_RS02685	COG0204	Acyl-transferase
VCD_RS02690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCD_RS02695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VCD_RS02705	COG3084	Protein conserved in bacteria
VCD_RS02715	COG4326	sporulation control protein
VCD_RS02720	COG1272	protein, Hemolysin III
VCD_RS02730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCD_RS02735	COG0569	domain protein
VCD_RS02740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCD_RS02740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCD_RS02745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VCD_RS02750	COG0242	peptide deformylase activity
VCD_RS02755	COG1652	LysM domain
VCD_RS02760	COG0758	DNA mediated transformation
VCD_RS02765	COG2922	Belongs to the Smg family
VCD_RS02770	COG0551	DNA topoisomerase type I activity
VCD_RS02775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VCD_RS02780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VCD_RS02785	COG0009	L-threonylcarbamoyladenylate synthase
VCD_RS02790	COG0408	coproporphyrinogen oxidase activity
VCD_RS02795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VCD_RS02805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VCD_RS02845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VCD_RS02850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VCD_RS02860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCD_RS02865	COG2104	thiamine diphosphate biosynthetic process
VCD_RS02870	COG2022	thiamine diphosphate biosynthetic process
VCD_RS02875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCD_RS02880	COG0006	proline dipeptidase activity
VCD_RS02880	COG0006	proline dipeptidase activity
VCD_RS02900	COG1522	sequence-specific DNA binding
VCD_RS02905	COG5002	protein histidine kinase activity
VCD_RS02905	COG5001	Diguanylate cyclase
VCD_RS02925	COG0589	response to stress
VCD_RS02935	COG1528	Iron-storage protein
VCD_RS02945	COG2081	HI0933 family
VCD_RS02955	COG1322	Protein conserved in bacteria
VCD_RS02960	COG2226	methyltransferase
VCD_RS02975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCD_RS02980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCD_RS02985	COG0805	protein transport
VCD_RS02990	COG1858	cytochrome C peroxidase
VCD_RS02995	COG0534	Mate efflux family protein
VCD_RS03005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCD_RS03015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VCD_RS03020	COG3161	chorismate lyase activity
VCD_RS03030	COG1580	Controls the rotational direction of flagella during chemotaxis
VCD_RS03035	COG0840	transmembrane signaling receptor activity
VCD_RS03045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCD_RS03055	COG0084	hydrolase, TatD family'
VCD_RS03070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCD_RS03070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCD_RS03090	COG3078	GTPase activator activity
VCD_RS03105	COG3071	HemY protein
VCD_RS03110	COG2959	enzyme of heme biosynthesis
VCD_RS03115	COG1587	Uroporphyrinogen-III synthase
VCD_RS03120	COG0181	hydroxymethylbilane synthase activity
VCD_RS03135	COG1965	Belongs to the frataxin family
VCD_RS03145	COG0019	diaminopimelate decarboxylase activity
VCD_RS03150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VCD_RS03160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VCD_RS03165	COG1011	Hydrolase
VCD_RS03170	COG2199	diguanylate cyclase activity
VCD_RS03170	COG2200	EAL domain
VCD_RS03170	COG3287	FIST C domain
VCD_RS03190	COG0561	phosphatase activity
VCD_RS03195	COG2267	carboxylic ester hydrolase activity
VCD_RS03200	COG1280	lysine exporter protein (LysE YggA)
VCD_RS03205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCD_RS03210	COG0783	Belongs to the Dps family
VCD_RS03245	COG0742	ribosomal rna small subunit methyltransferase
VCD_RS03250	COG0552	protein localization to endoplasmic reticulum
VCD_RS03255	COG2884	Cell division ATP-binding protein ftsE
VCD_RS03260	COG2177	Part of the ABC transporter FtsEX involved in
VCD_RS03265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCD_RS03270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_RS03285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCD_RS03290	COG4206	TonB-dependent receptor
VCD_RS03295	COG1404	Belongs to the peptidase S8 family
VCD_RS03300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VCD_RS03350	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCD_RS03355	COG3300	MHYT domain
VCD_RS03355	COG5001	Diguanylate cyclase
VCD_RS03365	COG3852	Histidine kinase
VCD_RS03375	COG0174	glutamine synthetase
VCD_RS03385	COG1217	gtp-binding protein TYPA
VCD_RS03395	COG1295	ribonuclease BN
VCD_RS03400	COG1490	D-aminoacyl-tRNA deacylase activity
VCD_RS03405	COG0456	acetyltransferase
VCD_RS03415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VCD_RS03420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VCD_RS03425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VCD_RS03430	COG3031	protein transport across the cell outer membrane
VCD_RS03440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_RS03445	COG1459	type II secretion system
VCD_RS03450	COG2165	general secretion pathway protein
VCD_RS03455	COG2165	general secretion pathway protein
VCD_RS03460	COG2165	general secretion pathway protein
VCD_RS03465	COG4795	General secretion pathway protein
VCD_RS03470	COG3156	type II secretion system protein K
VCD_RS03475	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCD_RS03480	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCD_RS03490	COG1218	3'(2'),5'-bisphosphate nucleotidase
VCD_RS03495	COG0494	nUDIX hydrolase
VCD_RS03505	COG1040	competence protein
VCD_RS03510	COG0596	Alpha beta hydrolase
VCD_RS03520	COG2183	response to ionizing radiation
VCD_RS03525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCD_RS03540	COG2233	PERMEase
VCD_RS03545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VCD_RS03550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCD_RS03555	COG1758	RNA polymerase activity
VCD_RS03560	COG0194	GDP metabolic process
VCD_RS03565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VCD_RS03570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCD_RS03590	COG4232	protein-disulfide reductase activity
VCD_RS03605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCD_RS03610	COG1027	Aspartate ammonia-lyase
VCD_RS03615	COG3706	GGDEF domain
VCD_RS03620	COG3030	protein affecting phage T7 exclusion by the F plasmid
VCD_RS03625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VCD_RS03635	COG2205	protein histidine kinase activity
VCD_RS03640	COG0745	RESPONSE REGULATOR receiver
VCD_RS03650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VCD_RS03655	COG0205	6-phosphofructokinase activity
VCD_RS03660	COG1494	fructose-1,6-bisphosphatase
VCD_RS03665	COG3074	FtsZ-dependent cytokinesis
VCD_RS03670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VCD_RS03675	COG0527	aspartate kinase activity
VCD_RS03675	COG0460	homoserine dehydrogenase
VCD_RS03680	COG0626	cystathionine gamma-synthase activity
VCD_RS03685	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VCD_RS03690	COG0281	malic enzyme
VCD_RS03695	COG0254	rRNA binding
VCD_RS03700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VCD_RS03705	COG1609	Transcriptional regulator
VCD_RS03710	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCD_RS03715	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VCD_RS03720	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VCD_RS03725	COG1575	Belongs to the MenA family. Type 1 subfamily
VCD_RS03730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCD_RS03735	COG0534	Mate efflux family protein
VCD_RS03740	COG0149	triose-phosphate isomerase activity
VCD_RS03765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VCD_RS03770	COG0459	protein refolding
VCD_RS03780	COG1509	lysine 2,3-aminomutase activity
VCD_RS03785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCD_RS03795	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VCD_RS03800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VCD_RS03805	COG1053	succinate dehydrogenase
VCD_RS03810	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VCD_RS03815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCD_RS03820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VCD_RS03825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VCD_RS03830	COG1045	serine acetyltransferase
VCD_RS03840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VCD_RS03845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCD_RS03850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VCD_RS03855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCD_RS03860	COG0137	argininosuccinate synthase activity
VCD_RS03865	COG0165	Argininosuccinate lyase
VCD_RS03875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_RS03880	COG0678	peroxiredoxin activity
VCD_RS03880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCD_RS03890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VCD_RS03920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VCD_RS03925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VCD_RS03935	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VCD_RS03940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VCD_RS03945	COG0546	phosphoglycolate phosphatase activity
VCD_RS03950	COG0180	Tryptophanyl-tRNA synthetase
VCD_RS03965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCD_RS03975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VCD_RS03985	COG1012	belongs to the aldehyde dehydrogenase family
VCD_RS04000	COG3954	Phosphoribulokinase
VCD_RS04010	COG0429	hydrolase of the alpha beta-hydrolase fold
VCD_RS04020	COG0488	(ABC) transporter
VCD_RS04025	COG2249	NAD(P)H dehydrogenase (quinone) activity
VCD_RS04040	COG1047	Peptidyl-prolyl cis-trans
VCD_RS04055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VCD_RS04060	COG3083	sulfuric ester hydrolase activity
VCD_RS04065	COG0557	exoribonuclease II activity
VCD_RS04070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCD_RS04075	COG0051	transcription antitermination factor activity, RNA binding
VCD_RS04080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VCD_RS04085	COG0088	Forms part of the polypeptide exit tunnel
VCD_RS04090	COG0089	rRNA binding
VCD_RS04095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VCD_RS04100	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VCD_RS04105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VCD_RS04110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VCD_RS04115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VCD_RS04120	COG0255	Belongs to the universal ribosomal protein uL29 family
VCD_RS04125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VCD_RS04130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VCD_RS04135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VCD_RS04140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VCD_RS04145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VCD_RS04150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VCD_RS04160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VCD_RS04165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VCD_RS04170	COG1841	ribosomal large subunit assembly
VCD_RS04180	COG0201	protein transport
VCD_RS04185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCD_RS04190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VCD_RS04195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VCD_RS04200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VCD_RS04205	COG0202	RNA polymerase activity
VCD_RS04210	COG0203	ribosomal protein L17
VCD_RS04220	COG0545	Peptidyl-prolyl cis-trans isomerase
VCD_RS04225	COG3266	domain, Protein
VCD_RS04225	COG3061	Opacity-associated protein A
VCD_RS04230	COG0697	spore germination
VCD_RS04235	COG2153	protein acetylation
VCD_RS04240	COG0513	Belongs to the DEAD box helicase family
VCD_RS04250	COG0737	Belongs to the 5'-nucleotidase family
VCD_RS04255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCD_RS04255	COG1648	precorrin-2 dehydrogenase activity
VCD_RS04270	COG0529	Catalyzes the synthesis of activated sulfate
VCD_RS04290	COG1136	(ABC) transporter
VCD_RS04305	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VCD_RS04310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_RS04315	COG0729	surface antigen
VCD_RS04325	COG2105	PFAM AIG2 family protein
VCD_RS04330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VCD_RS04345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCD_RS04350	COG0163	prenyltransferase activity
VCD_RS04360	COG1178	ABC-type Fe3 transport system permease component
VCD_RS04365	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VCD_RS04370	COG3028	Belongs to the UPF0307 family
VCD_RS04375	COG0312	modulator of DNA gyrase
VCD_RS04380	COG2239	Acts as a magnesium transporter
VCD_RS04385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_RS04390	COG1660	Displays ATPase and GTPase activities
VCD_RS04395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_RS04400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCD_RS04410	COG1137	ATPase activity
VCD_RS04415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VCD_RS04430	COG0517	IMP dehydrogenase activity
VCD_RS04430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VCD_RS04445	COG1127	ABC transporter
VCD_RS04450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VCD_RS04455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCD_RS04460	COG2854	intermembrane phospholipid transfer
VCD_RS04470	COG5007	Belongs to the BolA IbaG family
VCD_RS04475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VCD_RS04485	COG0251	oxidation-reduction process
VCD_RS04495	COG0540	Belongs to the ATCase OTCase family
VCD_RS04510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VCD_RS04525	COG0564	pseudouridine synthase activity
VCD_RS04530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCD_RS04535	COG0525	valine-tRNA ligase activity
VCD_RS04540	COG2927	DNA polymerase III (CHI subunit)
VCD_RS04545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCD_RS04550	COG0795	lipopolysaccharide-transporting ATPase activity
VCD_RS04555	COG0795	lipopolysaccharide-transporting ATPase activity
VCD_RS04570	COG3437	response regulator, receiver
VCD_RS04615	COG0066	3-isopropylmalate dehydratase activity
VCD_RS04620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VCD_RS04625	COG0473	3-isopropylmalate dehydrogenase activity
VCD_RS04650	COG0583	DNA-binding transcription factor activity
VCD_RS04655	COG1022	Amp-dependent synthetase and ligase
VCD_RS04660	COG0028	Belongs to the TPP enzyme family
VCD_RS04665	COG0440	acetolactate synthase activity
VCD_RS04670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCD_RS04675	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VCD_RS04680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VCD_RS04685	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VCD_RS04690	COG3079	Belongs to the UPF0149 family
VCD_RS04695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_RS04700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_RS04715	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VCD_RS04725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VCD_RS04735	COG1595	DNA-templated transcription, initiation
VCD_RS04750	COG3086	response to oxidative stress
VCD_RS04755	COG0481	GTPase activity
VCD_RS04770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VCD_RS04775	COG1381	Involved in DNA repair and RecF pathway recombination
VCD_RS04780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VCD_RS04800	COG5001	Diguanylate cyclase
VCD_RS04815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCD_RS04820	COG3956	TIGRFAM MazG family protein
VCD_RS04825	COG0504	CTP synthase activity
VCD_RS04830	COG0148	phosphopyruvate hydratase activity
VCD_RS04840	COG3267	Type II secretory pathway component ExeA
VCD_RS04840	COG3409	Peptidoglycan-binding domain 1 protein
VCD_RS04850	COG4991	sh3 domain protein
VCD_RS04855	COG0306	phosphate transporter
VCD_RS04860	COG1392	Phosphate transport regulator
VCD_RS04865	COG3025	triphosphatase activity
VCD_RS04870	COG0840	transmembrane signaling receptor activity
VCD_RS04875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VCD_RS04885	COG1538	Outer membrane efflux protein
VCD_RS04890	COG0494	nUDIX hydrolase
VCD_RS04895	COG3151	Protein conserved in bacteria
VCD_RS04905	COG3150	esterase
VCD_RS04910	COG0187	DNA topoisomerase II activity
VCD_RS04915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VCD_RS04925	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VCD_RS04930	COG0237	dephospho-CoA kinase activity
VCD_RS04940	COG1459	type II secretion system
VCD_RS04945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_RS04965	COG0716	FMN binding
VCD_RS04970	COG4974	Belongs to the 'phage' integrase family
VCD_RS04975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCD_RS04980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VCD_RS04985	COG0737	Belongs to the 5'-nucleotidase family
VCD_RS04990	COG2186	Transcriptional regulator
VCD_RS04995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VCD_RS05000	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCD_RS05005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCD_RS05015	COG3116	cell division
VCD_RS05020	COG0768	penicillin binding
VCD_RS05025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VCD_RS05030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VCD_RS05040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VCD_RS05045	COG0772	Belongs to the SEDS family
VCD_RS05055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCD_RS05060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VCD_RS05065	COG0849	cell division
VCD_RS05070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VCD_RS05075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VCD_RS05085	COG0653	protein targeting
VCD_RS05095	COG0494	nUDIX hydrolase
VCD_RS05100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VCD_RS05110	COG0505	Belongs to the CarA family
VCD_RS05115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCD_RS05135	COG4172	Belongs to the ABC transporter superfamily
VCD_RS05145	COG0730	response to heat
VCD_RS05150	COG0583	DNA-binding transcription factor activity
VCD_RS05155	COG2860	membrane
VCD_RS05160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCD_RS05170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VCD_RS05180	COG0493	'glutamate synthase
VCD_RS05185	COG0067	glutamate synthase
VCD_RS05185	COG0069	glutamate synthase activity
VCD_RS05185	COG0070	glutamate synthase
VCD_RS05195	COG0070	glutamate synthase
VCD_RS05195	COG0067	glutamate synthase
VCD_RS05195	COG0069	glutamate synthase activity
VCD_RS05200	COG1242	4 iron, 4 sulfur cluster binding
VCD_RS05205	COG3706	GGDEF domain
VCD_RS05205	COG4251	negative regulation of phosphorylation
VCD_RS05205	COG2203	Gaf domain
VCD_RS05205	COG5001	Diguanylate cyclase
VCD_RS05210	COG2198	Histidine kinase
VCD_RS05210	COG0784	Response regulator, receiver
VCD_RS05210	COG5002	protein histidine kinase activity
VCD_RS05215	COG0745	RESPONSE REGULATOR receiver
VCD_RS05225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCD_RS05245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VCD_RS05250	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VCD_RS05255	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VCD_RS05260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VCD_RS05275	COG1115	amino acid carrier protein
VCD_RS05280	COG3022	response to hydroperoxide
VCD_RS05285	COG0084	hydrolase, TatD family'
VCD_RS05290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCD_RS05300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VCD_RS05305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VCD_RS05310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VCD_RS05315	COG0813	purine-nucleoside phosphorylase activity
VCD_RS05325	COG0560	Phosphoserine phosphatase
VCD_RS05335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VCD_RS05340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCD_RS05345	COG1022	Amp-dependent synthetase and ligase
VCD_RS05360	COG3250	beta-galactosidase activity
VCD_RS05365	COG1609	Transcriptional regulator
VCD_RS05370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_RS05385	COG0189	ligase activity
VCD_RS05385	COG0569	domain protein
VCD_RS05390	COG0456	acetyltransferase
VCD_RS05400	COG2171	N-acyltransferase activity
VCD_RS05405	COG3141	response to X-ray
VCD_RS05420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VCD_RS05425	COG1074	ATP-dependent DNA helicase activity
VCD_RS05430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VCD_RS05445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCD_RS05445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCD_RS05455	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VCD_RS05460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VCD_RS05465	COG2166	iron-sulfur cluster assembly
VCD_RS05470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCD_RS05475	COG0693	protein deglycase activity
VCD_RS05480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VCD_RS05485	COG3248	Nucleoside-binding outer membrane protein
VCD_RS05495	COG1595	DNA-templated transcription, initiation
VCD_RS05505	COG2211	Major facilitator Superfamily
VCD_RS05510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCD_RS05520	COG2813	Specifically methylates the guanine in position
VCD_RS05525	COG0271	Belongs to the BolA IbaG family
VCD_RS05530	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_RS05535	COG1805	sodium ion transport
VCD_RS05540	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_RS05545	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_RS05550	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCD_RS05555	COG2871	sodium ion transport
VCD_RS05560	COG1477	protein flavinylation
VCD_RS05585	COG3706	GGDEF domain
VCD_RS05590	COG0733	neurotransmitter:sodium symporter activity
VCD_RS05600	COG0189	ligase activity
VCD_RS05605	COG4067	protein conserved in archaea
VCD_RS05605	COG0189	ligase activity
VCD_RS05610	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCD_RS05615	COG2252	PERMEase
VCD_RS05620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VCD_RS05625	COG1073	alpha beta
VCD_RS05635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VCD_RS05640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VCD_RS05645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VCD_RS05650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCD_RS05650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCD_RS05665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VCD_RS05670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCD_RS05675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VCD_RS05680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VCD_RS05690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VCD_RS05695	COG0024	Methionine aminopeptidase
VCD_RS05700	COG0052	Belongs to the universal ribosomal protein uS2 family
VCD_RS05705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VCD_RS05710	COG0528	UMP kinase activity
VCD_RS05715	COG0233	cytoplasmic translational termination
VCD_RS05720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VCD_RS05725	COG0575	Belongs to the CDS family
VCD_RS05730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VCD_RS05735	COG0750	zinc metalloprotease
VCD_RS05745	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VCD_RS05750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_RS05755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCD_RS05760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_RS05765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_RS05770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VCD_RS05775	COG0587	DNA-directed DNA polymerase activity
VCD_RS05780	COG0825	malonyl-CoA metabolic process
VCD_RS05785	COG0037	tRNA processing
VCD_RS05795	COG3479	Phenolic acid decarboxylase
VCD_RS05800	COG0347	Belongs to the P(II) protein family
VCD_RS05805	COG3021	interspecies interaction between organisms
VCD_RS05810	COG0741	lytic transglycosylase activity
VCD_RS05810	COG1388	LysM domain
VCD_RS05815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCD_RS05820	COG2226	methyltransferase
VCD_RS05825	COG0328	RNA-DNA hybrid ribonuclease activity
VCD_RS05840	COG1960	acyl-CoA dehydrogenase activity
VCD_RS05845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCD_RS05850	COG0121	glutamine amidotransferase
VCD_RS05855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VCD_RS05860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VCD_RS05865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VCD_RS05875	COG1187	pseudouridine synthase activity
VCD_RS05880	COG2840	Smr protein MutS2
VCD_RS05895	COG3735	TraB family
VCD_RS05910	COG2608	mercury ion transmembrane transporter activity
VCD_RS05910	COG2217	Heavy metal translocating P-type atpase
VCD_RS05915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCD_RS05930	COG1629	transport
VCD_RS05930	COG4774	siderophore transport
VCD_RS05935	COG2375	cellular response to nickel ion
VCD_RS05940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCD_RS05940	COG3433	isochorismatase activity
VCD_RS05940	COG2226	methyltransferase
VCD_RS05975	COG0835	chemotaxis
VCD_RS05975	COG0784	Response regulator, receiver
VCD_RS05980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCD_RS05985	COG1815	bacterial-type flagellum-dependent cell motility
VCD_RS06000	COG1749	Flagellar hook protein flgE
VCD_RS06005	COG4787	bacterial-type flagellum-dependent cell motility
VCD_RS06015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VCD_RS06020	COG1706	bacterial-type flagellum-dependent cell motility
VCD_RS06025	COG1705	Flagellar rod assembly protein muramidase FlgJ
VCD_RS06025	COG3951	Flagellar rod assembly protein muramidase FlgJ
VCD_RS06045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_RS06050	COG4974	Belongs to the 'phage' integrase family
VCD_RS06145	COG4695	Portal protein
VCD_RS06275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_RS06360	COG0012	GTP binding
VCD_RS06365	COG0193	aminoacyl-tRNA hydrolase activity
VCD_RS06370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VCD_RS06375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VCD_RS06380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VCD_RS06385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VCD_RS06390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VCD_RS06395	COG2890	protein-(glutamine-N5) methyltransferase activity
VCD_RS06405	COG2912	Transglutaminase-like superfamily
VCD_RS06410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VCD_RS06415	COG0737	Belongs to the 5'-nucleotidase family
VCD_RS06420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VCD_RS06425	COG2233	PERMEase
VCD_RS06445	COG1393	Belongs to the ArsC family
VCD_RS06450	COG4783	chaperone-mediated protein folding
VCD_RS06470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VCD_RS06485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VCD_RS06495	COG1876	peptidase activity
VCD_RS06505	COG1393	Belongs to the ArsC family
VCD_RS06525	COG2837	iron assimilation
VCD_RS06530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_RS06535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_RS06540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCD_RS06545	COG1334	flagellar protein FlaG
VCD_RS06550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VCD_RS06560	COG1516	flagellar protein fliS
VCD_RS06580	COG1677	Flagellar hook-basal body complex protein FliE
VCD_RS06590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VCD_RS06595	COG1317	bacterial-type flagellum organization
VCD_RS06615	COG1580	Controls the rotational direction of flagella during chemotaxis
VCD_RS06640	COG1987	bacterial-type flagellum assembly
VCD_RS06645	COG1684	flagellar biosynthetic protein fliR
VCD_RS06655	COG2840	Smr protein MutS2
VCD_RS06660	COG2890	protein-(glutamine-N5) methyltransferase activity
VCD_RS06670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VCD_RS06675	COG2860	membrane
VCD_RS06680	COG3101	peptidyl-lysine hydroxylation
VCD_RS06690	COG0431	NADPH-dependent FMN reductase
VCD_RS06700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCD_RS06705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCD_RS06710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCD_RS06715	COG0735	belongs to the Fur family
VCD_RS06725	COG0583	DNA-binding transcription factor activity
VCD_RS06735	COG1346	cytolysis
VCD_RS06750	COG0596	Alpha beta hydrolase
VCD_RS06755	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VCD_RS06760	COG0033	Phosphoglucomutase
VCD_RS06770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VCD_RS06775	COG0372	Belongs to the citrate synthase family
VCD_RS06780	COG2009	succinate dehydrogenase
VCD_RS06785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VCD_RS06790	COG1053	succinate dehydrogenase
VCD_RS06800	COG0567	Dehydrogenase, E1 component
VCD_RS06805	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCD_RS06810	COG0045	succinate-CoA ligase (ADP-forming) activity
VCD_RS06820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VCD_RS06825	COG1121	(ABC) transporter
VCD_RS06830	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VCD_RS06835	COG4977	sequence-specific DNA binding
VCD_RS06840	COG1918	ferrous iron import across plasma membrane
VCD_RS06860	COG0018	arginyl-trna synthetase
VCD_RS06870	COG1025	Belongs to the peptidase M16 family
VCD_RS06875	COG2062	phosphohistidine phosphatase, SixA
VCD_RS06905	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VCD_RS06910	COG2198	Histidine kinase
VCD_RS06910	COG0643	Histidine kinase
VCD_RS06910	COG0784	Response regulator, receiver
VCD_RS06915	COG2201	protein-glutamate methylesterase activity
VCD_RS06920	COG1192	Involved in chromosome partitioning
VCD_RS06930	COG0835	chemotaxis
VCD_RS06940	COG4133	protoheme IX ABC transporter activity
VCD_RS06945	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCD_RS06950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCD_RS06960	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VCD_RS06965	COG1138	Cytochrome C-type biogenesis protein
VCD_RS06970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VCD_RS06975	COG3088	subunit of a heme lyase
VCD_RS06975	COG4235	cytochrome complex assembly
VCD_RS06985	COG2853	Lipoprotein
VCD_RS07005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VCD_RS07010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCD_RS07015	COG0123	including yeast histone deacetylase and acetoin utilization protein
VCD_RS07030	COG3083	sulfuric ester hydrolase activity
VCD_RS07035	COG3082	Protein of unknown function (DUF1414)
VCD_RS07040	COG3081	Nucleoid-associated protein
VCD_RS07050	COG1757	Na H antiporter
VCD_RS07055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCD_RS07060	COG2095	MarC family integral membrane protein
VCD_RS07065	COG1454	alcohol dehydrogenase
VCD_RS07065	COG1012	belongs to the aldehyde dehydrogenase family
VCD_RS07075	COG0659	secondary active sulfate transmembrane transporter activity
VCD_RS07080	COG1530	ribonuclease E activity
VCD_RS07095	COG0564	pseudouridine synthase activity
VCD_RS07100	COG0424	maF-like protein
VCD_RS07105	COG1399	metal-binding, possibly nucleic acid-binding protein
VCD_RS07110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VCD_RS07115	COG0416	fatty acid biosynthetic process
VCD_RS07120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCD_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
VCD_RS07135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VCD_RS07140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCD_RS07145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VCD_RS07150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VCD_RS07155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VCD_RS07165	COG0084	hydrolase, TatD family'
VCD_RS07170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_RS07170	COG1263	PTS System
VCD_RS07175	COG0733	neurotransmitter:sodium symporter activity
VCD_RS07190	COG4667	esterase of the alpha-beta hydrolase superfamily
VCD_RS07200	COG1940	carbohydrate kinase activity
VCD_RS07205	COG0784	Response regulator, receiver
VCD_RS07205	COG0835	chemotaxis
VCD_RS07220	COG2226	methyltransferase
VCD_RS07230	COG0676	glucose-6-phosphate 1-epimerase activity
VCD_RS07235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCD_RS07240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_RS07250	COG3139	Protein of unknown function (DUF1315)
VCD_RS07255	COG0252	asparaginase activity
VCD_RS07260	COG0616	signal peptide processing
VCD_RS07265	COG1902	pentaerythritol trinitrate reductase activity
VCD_RS07265	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCD_RS07270	COG0788	formyltetrahydrofolate deformylase activity
VCD_RS07280	COG1199	ATP-dependent helicase activity
VCD_RS07285	COG1214	PFAM Peptidase M22, glycoprotease
VCD_RS07300	COG0596	Alpha beta hydrolase
VCD_RS07305	COG0318	PFAM AMP-dependent synthetase and ligase
VCD_RS07310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VCD_RS07330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCD_RS07335	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VCD_RS07340	COG0436	Aminotransferase
VCD_RS07345	COG1169	isochorismate synthase
VCD_RS07350	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VCD_RS07355	COG0596	Alpha beta hydrolase
VCD_RS07375	COG3135	benzoate transporter
VCD_RS07380	COG1396	sequence-specific DNA binding
VCD_RS07385	COG0840	transmembrane signaling receptor activity
VCD_RS07395	COG0477	Major facilitator Superfamily
VCD_RS07415	COG3015	lipoprotein NlpE involved in copper resistance
VCD_RS07420	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VCD_RS07425	COG2894	cell division
VCD_RS07430	COG0850	regulation of cytokinetic process
VCD_RS07435	COG3100	YcgL domain-containing protein
VCD_RS07440	COG2951	lytic endotransglycosylase activity
VCD_RS07450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCD_RS07455	COG3469	chitinase activity
VCD_RS07455	COG3325	Belongs to the glycosyl hydrolase 18 family
VCD_RS07460	COG3005	denitrification pathway
VCD_RS07465	COG0243	molybdopterin cofactor binding
VCD_RS07480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_RS07490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VCD_RS07525	COG4589	Belongs to the CDS family
VCD_RS07535	COG3300	MHYT domain
VCD_RS07535	COG5001	Diguanylate cyclase
VCD_RS07550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VCD_RS07555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCD_RS07560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCD_RS07565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCD_RS07575	COG4191	Histidine kinase
VCD_RS07585	COG0544	peptidyl-prolyl cis-trans isomerase activity
VCD_RS07595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VCD_RS07600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VCD_RS07605	COG0776	regulation of translation
VCD_RS07610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCD_RS07615	COG1555	photosystem II stabilization
VCD_RS07620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VCD_RS07625	COG0539	negative regulation of cytoplasmic translation
VCD_RS07630	COG0776	regulation of translation
VCD_RS07635	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VCD_RS07640	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VCD_RS07660	COG0583	DNA-binding transcription factor activity
VCD_RS07670	COG0686	Belongs to the AlaDH PNT family
VCD_RS07680	COG1674	ftsk spoiiie
VCD_RS07685	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VCD_RS07690	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCD_RS07695	COG2186	Transcriptional regulator
VCD_RS07710	COG0537	adenosine 5'-monophosphoramidase activity
VCD_RS07735	COG3150	esterase
VCD_RS07740	COG1252	NADH dehydrogenase
VCD_RS07760	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VCD_RS07770	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCD_RS07775	COG1136	(ABC) transporter
VCD_RS07780	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCD_RS07790	COG2333	competence protein COMEC
VCD_RS07790	COG0658	competence protein
VCD_RS07795	COG1132	(ABC) transporter
VCD_RS07800	COG1663	tetraacyldisaccharide 4'-kinase activity
VCD_RS07805	COG2835	tetraacyldisaccharide 4'-kinase activity
VCD_RS07810	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VCD_RS07815	COG2719	SpoVR family
VCD_RS07820	COG2718	Belongs to the UPF0229 family
VCD_RS07825	COG2766	serine protein kinase
VCD_RS07830	COG3013	Belongs to the UPF0304 family
VCD_RS07840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VCD_RS07845	COG0840	transmembrane signaling receptor activity
VCD_RS07855	COG1882	Formate acetyltransferase
VCD_RS07880	COG4160	amino acid transport
VCD_RS07885	COG0708	Exodeoxyribonuclease III
VCD_RS07930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_RS07940	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_RS07955	COG3550	peptidyl-serine autophosphorylation
VCD_RS07970	COG0840	transmembrane signaling receptor activity
VCD_RS07980	COG3923	Primosomal replication protein n
VCD_RS07985	COG0730	response to heat
VCD_RS07990	COG1199	ATP-dependent helicase activity
VCD_RS07995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCD_RS08000	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCD_RS08005	COG3012	SEC-C Motif Domain Protein
VCD_RS08010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCD_RS08015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCD_RS08020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCD_RS08025	COG0215	cysteine-tRNA ligase activity
VCD_RS08030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VCD_RS08035	COG0632	four-way junction helicase activity
VCD_RS08045	COG1271	oxidase subunit
VCD_RS08050	COG1294	oxidase, subunit
VCD_RS08055	COG4890	Cyd operon protein YbgT
VCD_RS08060	COG3790	cyd operon protein YbgE
VCD_RS08065	COG0824	Thioesterase
VCD_RS08070	COG0811	peptide transport
VCD_RS08085	COG0823	Involved in the tonB-independent uptake of proteins
VCD_RS08090	COG2885	chlorophyll binding
VCD_RS08100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VCD_RS08110	COG0784	Response regulator, receiver
VCD_RS08110	COG5002	protein histidine kinase activity
VCD_RS08120	COG1482	cell wall glycoprotein biosynthetic process
VCD_RS08125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_RS08125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_RS08125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_RS08130	COG2207	Transcriptional regulator
VCD_RS08140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_RS08145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_RS08150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCD_RS08160	COG1012	belongs to the aldehyde dehydrogenase family
VCD_RS08165	COG3284	Transcriptional regulator
VCD_RS08170	COG4628	conserved protein (DUF2132)
VCD_RS08180	COG0415	Belongs to the DNA photolyase family
VCD_RS08255	COG0488	(ABC) transporter
VCD_RS08295	COG3941	tape measure
VCD_RS08315	COG2003	Belongs to the UPF0758 family
VCD_RS08325	COG4409	exo-alpha-(2->6)-sialidase activity
VCD_RS08330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCD_RS08335	COG1940	carbohydrate kinase activity
VCD_RS08350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCD_RS08355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCD_RS08360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCD_RS08365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCD_RS08370	COG1737	Transcriptional regulator
VCD_RS08375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCD_RS08380	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VCD_RS08400	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_RS08420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_RS08485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_RS08495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_RS08510	COG3550	peptidyl-serine autophosphorylation
VCD_RS08525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCD_RS08535	COG0582	viral genome integration into host DNA
VCD_RS08550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_RS08560	COG3008	intermembrane lipid transfer
VCD_RS08560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCD_RS08565	COG2995	paraquat-inducible protein a
VCD_RS08570	COG0668	transmembrane transport
VCD_RS08595	COG1309	transcriptional regulator
VCD_RS08600	COG1012	belongs to the aldehyde dehydrogenase family
VCD_RS08625	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCD_RS08630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VCD_RS08660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCD_RS08665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VCD_RS08670	COG0297	glycogen (starch) synthase activity
VCD_RS08690	COG3070	regulator of competence-specific genes
VCD_RS08695	COG1609	Transcriptional regulator
VCD_RS08700	COG3381	protein complex oligomerization
VCD_RS08705	COG0745	RESPONSE REGULATOR receiver
VCD_RS08710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCD_RS08715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCD_RS08725	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VCD_RS08745	COG1032	radical SAM domain protein
VCD_RS08750	COG5001	Diguanylate cyclase
VCD_RS08755	COG0612	Peptidase, M16
VCD_RS08770	COG0583	DNA-binding transcription factor activity
VCD_RS08775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VCD_RS08785	COG2350	Protein conserved in bacteria
VCD_RS08790	COG1607	acyl-coa hydrolase
VCD_RS08805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCD_RS08810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCD_RS08820	COG2116	formate transmembrane transporter activity
VCD_RS08830	COG4459	periplasmic nitrate reductase
VCD_RS08835	COG3005	denitrification pathway
VCD_RS08840	COG0243	molybdopterin cofactor binding
VCD_RS08860	COG1227	inorganic diphosphatase activity
VCD_RS08875	COG4172	Belongs to the ABC transporter superfamily
VCD_RS08890	COG4168	peptide transport system, permease
VCD_RS08900	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VCD_RS08905	COG1842	Phage shock protein A
VCD_RS08920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_RS08935	COG2818	Glycosylase
VCD_RS08940	COG0626	cystathionine gamma-synthase activity
VCD_RS08950	COG0733	neurotransmitter:sodium symporter activity
VCD_RS08955	COG0564	pseudouridine synthase activity
VCD_RS08960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VCD_RS08965	COG4136	ATPase activity
VCD_RS08970	COG4135	transport system, permease component
VCD_RS08975	COG4134	Bacterial extracellular solute-binding protein
VCD_RS08985	COG3313	Fe-S protein
VCD_RS08995	COG0842	Transport permease protein
VCD_RS09000	COG1131	(ABC) transporter
VCD_RS09005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_RS09010	COG0814	amino acid
VCD_RS09020	COG2239	Acts as a magnesium transporter
VCD_RS09025	COG0784	Response regulator, receiver
VCD_RS09025	COG2205	protein histidine kinase activity
VCD_RS09040	COG4934	collagen metabolic process
VCD_RS09070	COG0840	transmembrane signaling receptor activity
VCD_RS09085	COG2203	Gaf domain
VCD_RS09085	COG3706	GGDEF domain
VCD_RS09085	COG4251	negative regulation of phosphorylation
VCD_RS09085	COG5001	Diguanylate cyclase
VCD_RS09090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VCD_RS09110	COG1061	Type III restriction enzyme res subunit
VCD_RS09115	COG1187	pseudouridine synthase activity
VCD_RS09120	COG2814	Major facilitator Superfamily
VCD_RS09130	COG0702	epimerase
VCD_RS09135	COG0534	Mate efflux family protein
VCD_RS09140	COG4181	ATPase activity
VCD_RS09145	COG0577	efflux transmembrane transporter activity
VCD_RS09155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCD_RS09165	COG1748	Saccharopine dehydrogenase
VCD_RS09180	COG1538	Outer membrane efflux protein
VCD_RS09200	COG0583	DNA-binding transcription factor activity
VCD_RS09210	COG1451	nucleotide metabolic process
VCD_RS09215	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VCD_RS09225	COG3063	Type IV pilus biogenesis stability protein PilW
VCD_RS09230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VCD_RS09250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCD_RS09265	COG3290	protein histidine kinase activity
VCD_RS09270	COG4565	transcriptional regulatory protein
VCD_RS09280	COG0784	Response regulator, receiver
VCD_RS09280	COG0835	chemotaxis
VCD_RS09320	COG1085	galactose-1-phosphate uridylyltransferase
VCD_RS09325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VCD_RS09330	COG2017	converts alpha-aldose to the beta-anomer
VCD_RS09340	COG2200	EAL domain
VCD_RS09340	COG2199	diguanylate cyclase activity
VCD_RS09370	COG0753	catalase activity
VCD_RS09390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VCD_RS09400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCD_RS09440	COG1271	oxidase subunit
VCD_RS09445	COG1294	oxidase, subunit
VCD_RS09450	COG1136	(ABC) transporter
VCD_RS09450	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCD_RS09455	COG1136	(ABC) transporter
VCD_RS09455	COG0577	efflux transmembrane transporter activity
VCD_RS09460	COG1136	(ABC) transporter
VCD_RS09460	COG0577	efflux transmembrane transporter activity
VCD_RS09480	COG0583	DNA-binding transcription factor activity
VCD_RS09490	COG2723	6-phospho-beta-galactosidase activity
VCD_RS09495	COG1609	Transcriptional regulator
VCD_RS09500	COG0251	oxidation-reduction process
VCD_RS09505	COG2731	YhcH YjgK YiaL family protein
VCD_RS09510	COG0584	glycerophosphoryl diester phosphodiesterase
VCD_RS09515	COG1349	DNA-binding transcription factor activity
VCD_RS09520	COG3842	ATPase activity
VCD_RS09525	COG0395	ABC-type sugar transport system, permease component
VCD_RS09530	COG1175	transmembrane transport
VCD_RS09545	COG0811	peptide transport
VCD_RS09550	COG0811	peptide transport
VCD_RS09555	COG0848	biopolymer transport protein
VCD_RS09560	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCD_RS09570	COG1793	dna ligase
VCD_RS09580	COG0534	Mate efflux family protein
VCD_RS09590	COG3001	Fructosamine kinase
VCD_RS09600	COG0791	NLP P60 protein
VCD_RS09605	COG0840	transmembrane signaling receptor activity
VCD_RS09615	COG3148	PFAM DTW domain containing protein
VCD_RS09620	COG1940	carbohydrate kinase activity
VCD_RS09650	COG0746	molybdenum cofactor guanylyltransferase activity
VCD_RS09655	COG3842	ATPase activity
VCD_RS09660	COG4662	Binding-protein-dependent transport system inner membrane component
VCD_RS09670	COG2204	response regulator
VCD_RS09675	COG3852	Histidine kinase
VCD_RS09680	COG0488	(ABC) transporter
VCD_RS09685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VCD_RS09715	COG3383	formate dehydrogenase (NAD+) activity
VCD_RS09715	COG0243	molybdopterin cofactor binding
VCD_RS09720	COG0437	4 iron, 4 sulfur cluster binding
VCD_RS09735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VCD_RS09740	COG1666	GTP binding
VCD_RS09745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCD_RS09760	COG2996	Protein conserved in bacteria
VCD_RS09770	COG3008	intermembrane lipid transfer
VCD_RS09775	COG2995	paraquat-inducible protein a
VCD_RS09780	COG1132	(ABC) transporter
VCD_RS09785	COG1956	GAF domain-containing protein
VCD_RS09790	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VCD_RS09805	COG0308	aminopeptidase N
VCD_RS09820	COG0167	dihydroorotate dehydrogenase activity
VCD_RS09830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCD_RS09830	COG0116	Belongs to the methyltransferase superfamily
VCD_RS09840	COG0488	(ABC) transporter
VCD_RS09855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCD_RS09860	COG1067	ATP-dependent peptidase activity
VCD_RS09865	COG3120	sequence-specific DNA binding
VCD_RS09880	COG1073	alpha beta
VCD_RS09880	COG3064	Membrane
VCD_RS09880	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VCD_RS09885	COG2994	toxin metabolic process
VCD_RS09910	COG0784	Response regulator, receiver
VCD_RS09910	COG2205	protein histidine kinase activity
VCD_RS09925	COG3278	Belongs to the heme-copper respiratory oxidase family
VCD_RS09940	COG2010	Cytochrome c
VCD_RS09950	COG2217	Heavy metal translocating P-type atpase
VCD_RS09965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCD_RS09970	COG0589	response to stress
VCD_RS09995	COG3842	ATPase activity
VCD_RS10005	COG1177	transmembrane transport
VCD_RS10015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCD_RS10030	COG1115	amino acid carrier protein
VCD_RS10035	COG1280	lysine exporter protein (LysE YggA)
VCD_RS10050	COG3675	Pfam Lipase (class 3)
VCD_RS10060	COG3501	Rhs element vgr protein
VCD_RS10070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VCD_RS10080	COG2814	Major facilitator Superfamily
VCD_RS10085	COG1566	PFAM secretion protein HlyD family protein
VCD_RS10090	COG1538	Outer membrane efflux protein
VCD_RS10100	COG0513	Belongs to the DEAD box helicase family
VCD_RS10110	COG0840	transmembrane signaling receptor activity
VCD_RS10115	COG0840	transmembrane signaling receptor activity
VCD_RS10115	COG3290	protein histidine kinase activity
VCD_RS10120	COG0835	chemotaxis
VCD_RS10125	COG2201	protein-glutamate methylesterase activity
VCD_RS10135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VCD_RS10140	COG0643	Histidine kinase
VCD_RS10140	COG0784	Response regulator, receiver
VCD_RS10140	COG2198	Histidine kinase
VCD_RS10145	COG0643	Histidine kinase
VCD_RS10145	COG2198	Histidine kinase
VCD_RS10155	COG0745	RESPONSE REGULATOR receiver
VCD_RS10170	COG0415	Belongs to the DNA photolyase family
VCD_RS10175	COG0477	Major facilitator Superfamily
VCD_RS10180	COG0583	DNA-binding transcription factor activity
VCD_RS10190	COG0095	Lipoate-protein ligase
VCD_RS10195	COG0443	Heat shock 70 kDa protein
VCD_RS10205	COG1643	Atp-dependent helicase
VCD_RS10245	COG0443	Heat shock 70 kDa protein
VCD_RS10250	COG0443	Heat shock 70 kDa protein
VCD_RS10255	COG3706	GGDEF domain
VCD_RS10285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VCD_RS10290	COG0602	queuosine metabolic process
VCD_RS10295	COG0561	phosphatase activity
VCD_RS10305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCD_RS10310	COG4597	amino acid ABC transporter
VCD_RS10315	COG0765	amino acid transport
VCD_RS10320	COG1126	abc transporter atp-binding protein
VCD_RS10325	COG0670	Belongs to the BI1 family
VCD_RS10330	COG2920	part of a sulfur-relay system
VCD_RS10335	COG1254	Belongs to the acylphosphatase family
VCD_RS10340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCD_RS10345	COG3706	GGDEF domain
VCD_RS10365	COG3437	response regulator, receiver
VCD_RS10370	COG0625	glutathione transferase activity
VCD_RS10380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VCD_RS10390	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCD_RS10420	COG0372	Belongs to the citrate synthase family
VCD_RS10425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VCD_RS10465	COG1129	ABC transporter
VCD_RS10500	COG0745	RESPONSE REGULATOR receiver
VCD_RS10505	COG2205	protein histidine kinase activity
VCD_RS10510	COG3713	MltA-interacting MipA family protein
VCD_RS10515	COG2990	Protein conserved in bacteria
VCD_RS10525	COG4191	Histidine kinase
VCD_RS10525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCD_RS10530	COG0471	metal ion transport
VCD_RS10540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCD_RS10555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCD_RS10565	COG3768	UPF0283 membrane protein
VCD_RS10570	COG3106	COG3106 Predicted ATPase
VCD_RS10585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCD_RS10590	COG0494	nUDIX hydrolase
VCD_RS10595	COG0814	amino acid
VCD_RS10600	COG1760	l-serine dehydratase
VCD_RS10605	COG0720	synthase
VCD_RS10650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_RS10660	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCD_RS10675	COG3550	peptidyl-serine autophosphorylation
VCD_RS10690	COG0840	transmembrane signaling receptor activity
VCD_RS10695	COG0017	Asparaginyl-tRNA synthetase
VCD_RS10700	COG0351	phosphomethylpyrimidine kinase
VCD_RS10705	COG3437	response regulator, receiver
VCD_RS10705	COG2770	Histidine kinase
VCD_RS10715	COG1448	Aminotransferase
VCD_RS10730	COG0840	transmembrane signaling receptor activity
VCD_RS10735	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VCD_RS10740	COG2943	transferase activity, transferring hexosyl groups
VCD_RS10745	COG1609	Transcriptional regulator
VCD_RS10755	COG1486	melibiose metabolic process
VCD_RS10760	COG1447	Phosphotransferase system cellobiose-specific component IIA
VCD_RS10770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCD_RS10775	COG0726	polysaccharide deacetylase
VCD_RS10780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCD_RS10785	COG1846	Transcriptional regulator
VCD_RS10810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCD_RS10825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCD_RS10830	COG3108	Peptidase M15
VCD_RS10835	COG2989	Protein conserved in bacteria
VCD_RS10860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCD_RS10870	COG2814	Major facilitator Superfamily
VCD_RS10880	COG1054	Belongs to the UPF0176 family
VCD_RS10890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCD_RS10895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCD_RS10900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCD_RS10930	COG0840	transmembrane signaling receptor activity
VCD_RS10950	COG4139	cobalamin transport
VCD_RS10970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VCD_RS10975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VCD_RS10980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCD_RS10985	COG1823	symporter activity
VCD_RS10990	COG2925	Exonuclease
VCD_RS10995	COG1380	Effector of murein hydrolase LrgA
VCD_RS11000	COG1346	cytolysis
VCD_RS11040	COG0776	regulation of translation
VCD_RS11045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_RS11045	COG0072	phenylalanine-tRNA ligase activity
VCD_RS11050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VCD_RS11090	COG0322	excinuclease ABC activity
VCD_RS11095	COG2197	response regulator
VCD_RS11100	COG0417	DNA replication proofreading
VCD_RS11105	COG5001	Diguanylate cyclase
VCD_RS11115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCD_RS11120	COG3099	Belongs to the UPF0263 family
VCD_RS11135	COG1228	amidohydrolase
VCD_RS11140	COG0010	Belongs to the arginase family
VCD_RS11145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VCD_RS11150	COG2986	histidine ammonia-lyase
VCD_RS11170	COG0277	FAD linked oxidase domain protein
VCD_RS11170	COG0247	lactate metabolic process
VCD_RS11185	COG2885	chlorophyll binding
VCD_RS11205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VCD_RS11215	COG0281	malic enzyme
VCD_RS11225	COG2949	membrane
VCD_RS11230	COG3706	GGDEF domain
VCD_RS11235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCD_RS11245	COG0492	ferredoxin-NADP+ reductase activity
VCD_RS11250	COG4988	ABC transporter
VCD_RS11255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VCD_RS11260	COG1187	pseudouridine synthase activity
VCD_RS11265	COG0009	L-threonylcarbamoyladenylate synthase
VCD_RS11270	COG0613	PHP domain protein
VCD_RS11280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCD_RS11285	COG0512	Glutamine amidotransferase of anthranilate synthase
VCD_RS11290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VCD_RS11295	COG0134	indole-3-glycerol-phosphate synthase activity
VCD_RS11295	COG0135	phosphoribosylanthranilate isomerase activity
VCD_RS11300	COG0133	tryptophan synthase activity
VCD_RS11305	COG0159	tryptophan synthase activity
VCD_RS11315	COG1435	thymidine kinase activity
VCD_RS11320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VCD_RS11325	COG1801	Protein of unknown function DUF72
VCD_RS11330	COG4106	trans-aconitate 2-methyltransferase activity
VCD_RS11335	COG0500	methyltransferase
VCD_RS11340	COG4067	protein conserved in archaea
VCD_RS11340	COG0189	ligase activity
VCD_RS11355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VCD_RS11365	COG3852	Histidine kinase
VCD_RS11380	COG3070	regulator of competence-specific genes
VCD_RS11390	COG2431	L-lysine efflux transmembrane transporter activity
VCD_RS11400	COG0076	glutamate decarboxylase activity
VCD_RS11405	COG1737	Transcriptional regulator
VCD_RS11410	COG1454	alcohol dehydrogenase
VCD_RS11410	COG1012	belongs to the aldehyde dehydrogenase family
VCD_RS11415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCD_RS11420	COG3273	potassium ion transport
VCD_RS11420	COG2985	domain, Protein
VCD_RS11425	COG0542	response to heat
VCD_RS11430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VCD_RS11435	COG1278	Cold shock
VCD_RS11445	COG1187	pseudouridine synthase activity
VCD_RS11450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VCD_RS11450	COG0140	phosphoribosyl-ATP diphosphatase activity
VCD_RS11455	COG0107	imidazoleglycerol-phosphate synthase activity
VCD_RS11460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VCD_RS11465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VCD_RS11470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCD_RS11470	COG0131	Imidazoleglycerol-phosphate dehydratase
VCD_RS11475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VCD_RS11480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VCD_RS11485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VCD_RS11490	COG1757	Na H antiporter
VCD_RS11495	COG2916	Histone family protein nucleoid-structuring protein H-NS
VCD_RS11500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCD_RS11505	COG0482	sulfurtransferase activity
VCD_RS11510	COG2915	High frequency lysogenization protein hflD homolog
VCD_RS11515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VCD_RS11525	COG2268	Band 7 protein
VCD_RS11535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VCD_RS11550	COG0300	oxidoreductase activity
VCD_RS11560	COG0501	Belongs to the peptidase M48B family
VCD_RS11570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VCD_RS11575	COG2226	methyltransferase
VCD_RS11580	COG0156	8-amino-7-oxononanoate synthase activity
VCD_RS11585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCD_RS11590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VCD_RS11595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VCD_RS11600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VCD_RS11605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VCD_RS11615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCD_RS11620	COG2203	Gaf domain
VCD_RS11620	COG2199	diguanylate cyclase activity
VCD_RS11630	COG4120	Belongs to the binding-protein-dependent transport system permease family
VCD_RS11640	COG4628	conserved protein (DUF2132)
VCD_RS11645	COG3092	negative regulation of chromosome organization
VCD_RS11650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCD_RS11655	COG0857	belongs to the CobB CobQ family
VCD_RS11655	COG0280	phosphate acetyltransferase
VCD_RS11660	COG0435	Glutathione S-transferase
VCD_RS11665	COG4608	Belongs to the ABC transporter superfamily
VCD_RS11670	COG0444	Belongs to the ABC transporter superfamily
VCD_RS11675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCD_RS11680	COG0601	transmembrane transport
VCD_RS11700	COG2204	response regulator
VCD_RS11705	COG5001	Diguanylate cyclase
VCD_RS11705	COG3300	MHYT domain
VCD_RS11710	COG4191	Histidine kinase
VCD_RS11715	COG5002	protein histidine kinase activity
VCD_RS11725	COG2201	protein-glutamate methylesterase activity
VCD_RS11740	COG0009	L-threonylcarbamoyladenylate synthase
VCD_RS11760	COG1881	PFAM PEBP family protein
VCD_RS11785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCD_RS11790	COG0640	Transcriptional regulator
VCD_RS11795	COG3706	GGDEF domain
VCD_RS11815	COG1946	Acyl-CoA thioesterase
VCD_RS11820	COG1522	sequence-specific DNA binding
VCD_RS11830	COG0616	signal peptide processing
VCD_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
VCD_RS11840	COG2983	Belongs to the UPF0260 family
VCD_RS11850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VCD_RS11855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VCD_RS11865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VCD_RS11870	COG2832	Protein of unknown function (DUF454)
VCD_RS11880	COG0745	RESPONSE REGULATOR receiver
VCD_RS11885	COG0583	DNA-binding transcription factor activity
VCD_RS11890	COG0778	Nitroreductase
VCD_RS11895	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCD_RS11895	COG1024	Enoyl-CoA hydratase
VCD_RS11900	COG0183	Belongs to the thiolase family
VCD_RS11920	COG2067	long-chain fatty acid transport protein
VCD_RS11930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCD_RS11935	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VCD_RS11940	COG2982	Protein involved in outer membrane biogenesis
VCD_RS11945	COG0572	uridine kinase
VCD_RS11955	COG0489	protein tyrosine kinase activity
VCD_RS11960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_RS11960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCD_RS11970	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VCD_RS11985	COG0617	tRNA 3'-terminal CCA addition
VCD_RS11985	COG0517	IMP dehydrogenase activity
VCD_RS11985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VCD_RS11990	COG2199	diguanylate cyclase activity
VCD_RS11995	COG0314	molybdopterin synthase activity
VCD_RS12000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VCD_RS12005	COG0315	cyclic pyranopterin monophosphate synthase activity
VCD_RS12010	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCD_RS12015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VCD_RS12020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VCD_RS12025	COG2198	Histidine kinase
VCD_RS12030	COG2204	response regulator
VCD_RS12040	COG0556	nucleotide-excision repair
VCD_RS12050	COG4657	Part of a membrane complex involved in electron transport
VCD_RS12055	COG2878	Part of a membrane complex involved in electron transport
VCD_RS12060	COG4656	Part of a membrane complex involved in electron transport
VCD_RS12080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VCD_RS12085	COG0346	lactoylglutathione lyase activity
VCD_RS12105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VCD_RS12110	COG2056	Na+-H+ antiporter family
VCD_RS12115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VCD_RS12120	COG1286	toxin biosynthetic process
VCD_RS12125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VCD_RS12130	COG0285	dihydrofolate synthase activity
VCD_RS12135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VCD_RS12140	COG0101	tRNA pseudouridine synthase activity
VCD_RS12155	COG2190	(PTS) system
VCD_RS12155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_RS12155	COG1263	PTS System
VCD_RS12160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCD_RS12165	COG1846	Transcriptional regulator
VCD_RS12165	COG1940	carbohydrate kinase activity
VCD_RS12170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VCD_RS12170	COG4651	solute:proton antiporter activity
VCD_RS12175	COG0367	asparagine synthase
VCD_RS12190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VCD_RS12195	COG0563	adenylate kinase activity
VCD_RS12200	COG0326	Molecular chaperone. Has ATPase activity
VCD_RS12205	COG3710	Transcriptional regulator
VCD_RS12220	COG0622	Phosphoesterase
VCD_RS12225	COG1090	epimerase
VCD_RS12230	COG0300	oxidoreductase activity
VCD_RS12235	COG3118	belongs to the thioredoxin family
VCD_RS12240	COG0330	HflC and HflK could
VCD_RS12245	COG1585	Membrane protein implicated in regulation of membrane protease activity
VCD_RS12250	COG0789	Transcriptional regulator
VCD_RS12265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VCD_RS12270	COG3115	cell septum assembly
VCD_RS12275	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VCD_RS12280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VCD_RS12290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCD_RS12300	COG2190	(PTS) system
VCD_RS12305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_RS12310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCD_RS12315	COG1702	phosphate starvation-inducible protein PhoH
VCD_RS12325	COG4535	Mg2 and Co2 transporter CorC
VCD_RS12330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VCD_RS12335	COG2888	peptidyl-tyrosine sulfation
VCD_RS12340	COG0495	leucyl-tRNA aminoacylation
VCD_RS12345	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VCD_RS12350	COG1466	dna polymerase III delta subunit
VCD_RS12355	COG0799	negative regulation of ribosome biogenesis
VCD_RS12360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VCD_RS12365	COG0768	penicillin binding
VCD_RS12370	COG0772	Belongs to the SEDS family
VCD_RS12375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCD_RS12380	COG1686	Belongs to the peptidase S11 family
VCD_RS12390	COG2921	Belongs to the UPF0250 family
VCD_RS12395	COG0321	lipoyl(octanoyl) transferase activity
VCD_RS12400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VCD_RS12410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VCD_RS12435	COG1596	polysaccharide export
VCD_RS12445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCD_RS12475	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VCD_RS12485	COG0438	transferase activity, transferring glycosyl groups
VCD_RS12495	COG1045	serine acetyltransferase
VCD_RS12515	COG0110	maltose O-acetyltransferase activity
VCD_RS12520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VCD_RS12525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VCD_RS12530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCD_RS12535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCD_RS12565	COG0366	Alpha amylase catalytic
VCD_RS12570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCD_RS12570	COG1263	PTS System
VCD_RS12575	COG1609	Transcriptional regulator
VCD_RS12580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCD_RS12585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VCD_RS12590	COG2011	ABC-type metal ion transport system permease component
VCD_RS12595	COG1464	Belongs to the NlpA lipoprotein family
VCD_RS12600	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VCD_RS12610	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCD_RS12610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCD_RS12625	COG1611	Belongs to the LOG family
VCD_RS12630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCD_RS12635	COG2363	Small membrane protein
VCD_RS12640	COG0583	DNA-binding transcription factor activity
VCD_RS12650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCD_RS12650	COG0301	tRNA thio-modification
VCD_RS12660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VCD_RS12665	COG1722	exodeoxyribonuclease VII activity
VCD_RS12670	COG0142	geranyltranstransferase activity
VCD_RS12675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VCD_RS12680	COG0564	pseudouridine synthase activity
VCD_RS12685	COG3098	single-species biofilm formation
VCD_RS12700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCD_RS12710	COG1671	Belongs to the UPF0178 family
VCD_RS12715	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCD_RS12720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCD_RS12725	COG0254	rRNA binding
VCD_RS12730	COG1720	tRNA m6t6A37 methyltransferase activity
VCD_RS12735	COG0442	prolyl-tRNA aminoacylation
VCD_RS12765	COG0047	phosphoribosylformylglycinamidine synthase activity
VCD_RS12765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCD_RS12775	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VCD_RS12790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCD_RS12825	COG0484	heat shock protein binding
VCD_RS12830	COG0443	Heat shock 70 kDa protein
VCD_RS12835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VCD_RS12840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VCD_RS12845	COG0497	DNA recombination
VCD_RS12850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCD_RS12855	COG2914	Belongs to the UPF0125 (RnfH) family
VCD_RS12860	COG2867	negative regulation of translational initiation
VCD_RS12865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VCD_RS12880	COG3064	Membrane
VCD_RS12890	COG0739	heme binding
VCD_RS12910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VCD_RS12915	COG2207	Transcriptional regulator
VCD_RS12925	COG1459	type II secretion system
VCD_RS12930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCD_RS12950	COG4796	Type ii and iii secretion system protein
VCD_RS12965	COG2165	general secretion pathway protein
VCD_RS12975	COG3710	Transcriptional regulator
VCD_RS12980	COG0840	transmembrane signaling receptor activity
VCD_RS12985	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VCD_RS13005	COG1012	belongs to the aldehyde dehydrogenase family
VCD_RS13075	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VCD_RS13080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VCD_RS13085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCD_RS13105	COG3051	citrate lyase alpha subunit
VCD_RS13110	COG2301	Belongs to the HpcH HpaI aldolase family
VCD_RS13120	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VCD_RS13130	COG3630	sodium ion export across plasma membrane
VCD_RS13135	COG0511	ligase activity, forming carbon-carbon bonds
VCD_RS13135	COG5016	pyruvate
VCD_RS13140	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VCD_RS13165	COG0583	DNA-binding transcription factor activity
VCD_RS13175	COG1115	amino acid carrier protein
VCD_RS13180	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VCD_RS13185	COG0583	DNA-binding transcription factor activity
VCD_RS13195	COG1120	ATPase activity
VCD_RS13200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCD_RS13205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCD_RS13210	COG4592	Periplasmic binding protein
VCD_RS13220	COG1028	Short-chain dehydrogenase reductase Sdr
VCD_RS13225	COG1169	isochorismate synthase
VCD_RS13230	COG1021	2,3-dihydroxybenzoate-AMP ligase
VCD_RS13235	COG3433	isochorismatase activity
VCD_RS13235	COG1535	isochorismatase
VCD_RS13240	COG1584	GPR1 FUN34 yaaH family protein
VCD_RS13250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VCD_RS13250	COG0519	Catalyzes the synthesis of GMP from XMP
VCD_RS13255	COG0517	IMP dehydrogenase activity
VCD_RS13255	COG0516	GMP reductase activity
VCD_RS13260	COG1570	exodeoxyribonuclease VII activity
VCD_RS13275	COG1160	GTP binding
VCD_RS13280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCD_RS13285	COG2976	Protein conserved in bacteria
VCD_RS13290	COG0124	histidyl-tRNA synthetase
VCD_RS13295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VCD_RS13305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VCD_RS13310	COG0105	UTP biosynthetic process
VCD_RS13315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCD_RS13320	COG2975	iron-sulfur cluster assembly
VCD_RS13325	COG0633	Ferredoxin
VCD_RS13330	COG0443	Heat shock 70 kDa protein
VCD_RS13335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCD_RS13345	COG0822	iron-sulfur transferase activity
VCD_RS13350	COG1104	cysteine desulfurase activity
VCD_RS13355	COG1959	2 iron, 2 sulfur cluster binding
VCD_RS13365	COG0483	inositol monophosphate 1-phosphatase activity
VCD_RS13370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCD_RS13375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCD_RS13380	COG1862	Preprotein translocase
VCD_RS13400	COG0517	IMP dehydrogenase activity
VCD_RS13410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VCD_RS13415	COG0583	DNA-binding transcription factor activity
VCD_RS13420	COG0450	alkyl hydroperoxide reductase
VCD_RS13425	COG3142	Participates in the control of copper homeostasis
VCD_RS13440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCD_RS13445	COG0581	inorganic phosphate transmembrane transporter activity
VCD_RS13455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VCD_RS13460	COG0248	Ppx GppA phosphatase
VCD_RS13470	COG5002	protein histidine kinase activity
VCD_RS13475	COG0745	RESPONSE REGULATOR receiver
VCD_RS13485	COG0826	peptidase U32
VCD_RS13490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCD_RS13530	COG0542	response to heat
VCD_RS13540	COG0564	pseudouridine synthase activity
VCD_RS13545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCD_RS13550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCD_RS13555	COG0077	Prephenate dehydratase
VCD_RS13555	COG1605	Chorismate mutase
VCD_RS13560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VCD_RS13565	COG5001	Diguanylate cyclase
VCD_RS13575	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VCD_RS13585	COG0488	(ABC) transporter
VCD_RS13595	COG1605	Chorismate mutase
VCD_RS13595	COG0287	Prephenate dehydrogenase
VCD_RS13600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCD_RS13605	COG3275	phosphorelay sensor kinase activity
VCD_RS13610	COG3279	Response regulator of the LytR AlgR family
VCD_RS13620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VCD_RS13625	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCD_RS13640	COG1966	Carbon starvation protein
VCD_RS13645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VCD_RS13650	COG1047	Peptidyl-prolyl cis-trans
VCD_RS13665	COG0196	riboflavin kinase activity
VCD_RS13670	COG0728	peptidoglycan biosynthetic process
VCD_RS13675	COG0268	Binds directly to 16S ribosomal RNA
VCD_RS13680	COG0640	Transcriptional regulator
VCD_RS13685	COG0583	DNA-binding transcription factor activity
VCD_RS13690	COG1283	sodium-dependent phosphate transmembrane transporter activity
VCD_RS13700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VCD_RS13705	COG0730	response to heat
VCD_RS13710	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VCD_RS13715	COG0494	nUDIX hydrolase
VCD_RS13730	COG0667	Aldo Keto reductase
VCD_RS13740	COG2204	response regulator
VCD_RS13745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VCD_RS13750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VCD_RS13765	COG0513	Belongs to the DEAD box helicase family
VCD_RS13880	COG2003	Belongs to the UPF0758 family
VCD_RS13905	COG0714	Associated with various cellular activities
VCD_RS13920	COG0629	single-stranded DNA binding
VCD_RS13960	COG0681	Belongs to the peptidase S26 family
VCD_RS13975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCD_RS13980	COG2204	response regulator
VCD_RS14070	COG1196	nuclear chromosome segregation
VCD_RS14130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCD_RS14160	COG0640	Transcriptional regulator
VCD_RS14165	COG1230	cation diffusion facilitator family transporter
VCD_RS14275	COG3153	acetyltransferase
VCD_RS14280	COG3154	lipid carrier protein
VCD_RS14290	COG0826	peptidase U32
VCD_RS14295	COG0826	peptidase U32
VCD_RS14320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VCD_RS14330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VCD_RS14335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VCD_RS14340	COG0195	Participates in both transcription termination and antitermination
VCD_RS14345	COG0779	Required for maturation of 30S ribosomal subunits
VCD_RS14360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCD_RS14370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VCD_RS14375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VCD_RS14380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VCD_RS14385	COG1534	Rna-binding protein
VCD_RS14390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCD_RS14395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCD_RS14400	COG2027	D-alanyl-D-alanine carboxypeptidase
VCD_RS14405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCD_RS14410	COG0739	heme binding
VCD_RS14425	COG0316	Belongs to the HesB IscA family
VCD_RS14435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VCD_RS14445	COG0628	permease
VCD_RS14450	COG2813	Specifically methylates the guanine in position
VCD_RS14455	COG2205	protein histidine kinase activity
VCD_RS14455	COG0784	Response regulator, receiver
VCD_RS14465	COG0747	negative chemotaxis
VCD_RS14470	COG0601	transmembrane transport
VCD_RS14475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCD_RS14480	COG0444	Belongs to the ABC transporter superfamily
VCD_RS14485	COG4608	Belongs to the ABC transporter superfamily
VCD_RS14495	COG2971	BadF BadG BcrA BcrD
VCD_RS14515	COG3842	ATPase activity
VCD_RS14525	COG1840	ABC-type Fe3 transport system, periplasmic component
VCD_RS14530	COG0004	ammonium transporteR
VCD_RS14535	COG0347	Belongs to the P(II) protein family
VCD_RS14540	COG3112	Uncharacterised protein family (UPF0231)
VCD_RS14545	COG1049	propionate catabolic process, 2-methylcitrate cycle
VCD_RS14550	COG1752	Esterase of the alpha-beta hydrolase superfamily
VCD_RS14555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCD_RS14560	COG1643	Atp-dependent helicase
VCD_RS14570	COG1489	DNA binding
VCD_RS14580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCD_RS14590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCD_RS14650	COG3107	peptidoglycan biosynthetic process
VCD_RS14810	COG4208	sulfate ABC transporter
VCD_RS14955	COG0840	transmembrane signaling receptor activity
VCD_RS15360	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_RS15370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCD_RS15450	COG3164	Protein of unknown function
VCD_RS15660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCD_RS15750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCD_RS15755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCD_RS15800	COG0471	metal ion transport
VCD_RS15800	COG0490	domain, Protein
VCD_RS15975	COG0248	Ppx GppA phosphatase
VCD_RS16025	COG0439	Biotin carboxylase
VCD_RS16380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VCD_RS16405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCD_RS16595	COG3621	Patatin-like phospholipase
VCD_RS16665	COG0210	DNA helicase
VCD_RS16835	COG0445	tRNA wobble uridine modification
VCD_RS16920	COG3977	Valine--pyruvate aminotransferase
VCD_RS17115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCD_RS17190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VCD_RS17510	COG1404	Belongs to the peptidase S8 family
VCD_RS17745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCD_RS18150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCD_RS18255	COG0557	exoribonuclease II activity
VCD_RS18625	COG0525	valine-tRNA ligase activity
VCD_RS18750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VCD_RS18780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCD_RS18850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VCD_RS18900	COG3850	Histidine kinase
VCD_RS18900	COG4999	Histidine kinase
VCD_RS18900	COG2205	protein histidine kinase activity
VCD_RS18900	COG3437	response regulator, receiver
VCD_RS18905	COG4999	Histidine kinase
VCD_RS18905	COG3850	Histidine kinase
VCD_RS18905	COG2205	protein histidine kinase activity
VCD_RS18905	COG3437	response regulator, receiver
VCD_RS19030	COG0306	phosphate transporter
VCD_RS19035	COG0306	phosphate transporter
VCD_RS19090	COG1538	Outer membrane efflux protein
VCD_RS19120	COG3150	esterase
VCD_RS19180	COG1459	type II secretion system
VCD_RS19355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VCD_RS19480	COG0653	protein targeting
VCD_RS19535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCD_RS19540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCD_RS19650	COG0069	glutamate synthase activity
VCD_RS19650	COG0067	glutamate synthase
VCD_RS19650	COG0070	glutamate synthase
VCD_RS19660	COG0070	glutamate synthase
VCD_RS19660	COG0069	glutamate synthase activity
VCD_RS19660	COG0067	glutamate synthase
VCD_RS19695	COG1242	4 iron, 4 sulfur cluster binding