locus-tag	class	description
MS6_RS00015	COG1126	abc transporter atp-binding protein
MS6_RS00020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MS6_RS00025	COG0594	ribonuclease P activity
MS6_RS00035	COG0706	membrane insertase activity
MS6_RS00040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MS6_RS00045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MS6_RS00055	COG0445	tRNA wobble uridine modification
MS6_RS00065	COG1192	Involved in chromosome partitioning
MS6_RS00070	COG1475	DNA binding
MS6_RS00075	COG3312	ion transport
MS6_RS00080	COG0356	it plays a direct role in the translocation of protons across the membrane
MS6_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MS6_RS00095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MS6_RS00100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MS6_RS00105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MS6_RS00110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MS6_RS00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MS6_RS00120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MS6_RS00125	COG2814	Major facilitator Superfamily
MS6_RS00130	COG0583	DNA-binding transcription factor activity
MS6_RS00135	COG0183	Belongs to the thiolase family
MS6_RS00145	COG1739	Uncharacterized protein family UPF0029
MS6_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MS6_RS00155	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
MS6_RS00200	COG0583	DNA-binding transcription factor activity
MS6_RS00205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MS6_RS00210	COG2960	long-chain fatty acid transporting porin activity
MS6_RS00215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_RS00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_RS00225	COG1309	transcriptional regulator
MS6_RS00280	COG0747	negative chemotaxis
MS6_RS00285	COG0601	transmembrane transport
MS6_RS00290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MS6_RS00300	COG2131	deaminase
MS6_RS00325	COG3621	Patatin-like phospholipase
MS6_RS00365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_RS00370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MS6_RS00380	COG0210	DNA helicase
MS6_RS00385	COG1280	lysine exporter protein (LysE YggA)
MS6_RS00400	COG2962	Rard protein
MS6_RS00405	COG0514	ATP-dependent DNA helicase (RecQ)
MS6_RS00420	COG1132	(ABC) transporter
MS6_RS00425	COG4774	siderophore transport
MS6_RS00430	COG1120	ATPase activity
MS6_RS00455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MS6_RS00460	COG1263	PTS System
MS6_RS00460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_RS00465	COG2862	Uncharacterized protein family, UPF0114
MS6_RS00470	COG1561	YicC-like family, N-terminal region
MS6_RS00475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MS6_RS00480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MS6_RS00485	COG1560	Kdo2-lipid A biosynthetic process
MS6_RS00490	COG1560	Kdo2-lipid A biosynthetic process
MS6_RS00495	COG1309	transcriptional regulator
MS6_RS00500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MS6_RS00510	COG2003	Belongs to the UPF0758 family
MS6_RS00515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MS6_RS00520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MS6_RS00530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MS6_RS00535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MS6_RS00540	COG0859	PFAM glycosyl transferase family 9
MS6_RS00545	COG0463	Glycosyl transferase, family 2
MS6_RS00550	COG0859	PFAM glycosyl transferase family 9
MS6_RS00555	COG3642	lipopolysaccharide core region biosynthetic process
MS6_RS00585	COG1519	Transferase
MS6_RS00620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MS6_RS00625	COG0662	Cupin 2, conserved barrel domain protein
MS6_RS00625	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MS6_RS00630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MS6_RS00635	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MS6_RS00665	COG0318	PFAM AMP-dependent synthetase and ligase
MS6_RS00670	COG1454	alcohol dehydrogenase
MS6_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
MS6_RS00685	COG5433	transposase activity
MS6_RS00715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MS6_RS00720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MS6_RS00725	COG0668	transmembrane transport
MS6_RS00730	COG1573	uracil-dna glycosylase
MS6_RS00740	COG3068	Protein conserved in bacteria
MS6_RS00750	COG1940	carbohydrate kinase activity
MS6_RS00755	COG1253	flavin adenine dinucleotide binding
MS6_RS00765	COG0776	regulation of translation
MS6_RS00775	COG0151	Belongs to the GarS family
MS6_RS00785	COG0789	Transcriptional regulator
MS6_RS00790	COG3710	Transcriptional regulator
MS6_RS00795	COG0531	amino acid
MS6_RS00800	COG1982	Orn Lys Arg decarboxylase major
MS6_RS00805	COG0840	transmembrane signaling receptor activity
MS6_RS00820	COG0800	Aldolase
MS6_RS00830	COG3265	gluconokinase activity
MS6_RS00835	COG0129	dihydroxy-acid dehydratase activity
MS6_RS00840	COG1609	Transcriptional regulator
MS6_RS00845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MS6_RS00850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MS6_RS00860	COG0439	Biotin carboxylase
MS6_RS00865	COG0511	ligase activity, forming carbon-carbon bonds
MS6_RS00870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MS6_RS00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MS6_RS00895	COG2814	Major facilitator Superfamily
MS6_RS00900	COG0784	Response regulator, receiver
MS6_RS00900	COG2205	protein histidine kinase activity
MS6_RS00905	COG0248	Ppx GppA phosphatase
MS6_RS00910	COG0513	Belongs to the DEAD box helicase family
MS6_RS00915	COG3118	belongs to the thioredoxin family
MS6_RS00930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MS6_RS00975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MS6_RS00990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MS6_RS01000	COG1072	(Pantothenic acid kinase))
MS6_RS01025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MS6_RS01030	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MS6_RS01035	COG0250	Participates in transcription elongation, termination and antitermination
MS6_RS01040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MS6_RS01050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MS6_RS01055	COG0222	ribosome binding
MS6_RS01060	COG0085	RNA polymerase activity
MS6_RS01065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MS6_RS01070	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MS6_RS01075	COG2816	NAD+ diphosphatase activity
MS6_RS01080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MS6_RS01095	COG4942	peptidase
MS6_RS01100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MS6_RS01110	COG0471	metal ion transport
MS6_RS01115	COG0688	phosphatidylethanolamine metabolic process
MS6_RS01120	COG1162	GTPase activity
MS6_RS01125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MS6_RS01160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MS6_RS01165	COG0802	atpase or kinase
MS6_RS01175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MS6_RS01180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MS6_RS01185	COG1923	regulation of RNA biosynthetic process
MS6_RS01190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MS6_RS01195	COG0330	HflC and HflK could
MS6_RS01200	COG0330	HflC and HflK could
MS6_RS01205	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MS6_RS01210	COG2900	Belongs to the SlyX family
MS6_RS01220	COG0545	Peptidyl-prolyl cis-trans isomerase
MS6_RS01225	COG2964	Protein conserved in bacteria
MS6_RS01230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MS6_RS01235	COG2923	Belongs to the DsrF TusC family
MS6_RS01250	COG0049	tRNA binding
MS6_RS01255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MS6_RS01260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MS6_RS01265	COG2906	2 iron, 2 sulfur cluster binding
MS6_RS01275	COG0360	Binds together with S18 to 16S ribosomal RNA
MS6_RS01280	COG2965	DNA replication, synthesis of RNA primer
MS6_RS01285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MS6_RS01290	COG0359	binds to the 23S rRNA
MS6_RS01305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MS6_RS01310	COG0432	Pfam Uncharacterised protein family UPF0047
MS6_RS01330	COG0735	belongs to the Fur family
MS6_RS01335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MS6_RS01360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MS6_RS01370	COG0175	sulfate reduction
MS6_RS01410	COG0646	methionine synthase
MS6_RS01410	COG1410	methionine synthase
MS6_RS01415	COG0527	aspartate kinase activity
MS6_RS01420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MS6_RS01430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MS6_RS01445	COG0629	single-stranded DNA binding
MS6_RS01450	COG2199	diguanylate cyclase activity
MS6_RS01450	COG2200	EAL domain
MS6_RS01475	COG3409	Peptidoglycan-binding domain 1 protein
MS6_RS01475	COG3267	Type II secretory pathway component ExeA
MS6_RS01485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_RS01490	COG1459	type II secretion system
MS6_RS01500	COG2165	general secretion pathway protein
MS6_RS01505	COG2165	general secretion pathway protein
MS6_RS01535	COG1077	Cell shape determining protein MreB Mrl
MS6_RS01540	COG1792	Involved in formation and maintenance of cell shape
MS6_RS01545	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MS6_RS01550	COG0424	maF-like protein
MS6_RS01560	COG3164	Protein of unknown function
MS6_RS01565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MS6_RS01570	COG0312	modulator of DNA gyrase
MS6_RS01575	COG2235	arginine
MS6_RS01595	COG0589	response to stress
MS6_RS01605	COG2358	TRAP transporter, solute receptor (TAXI family
MS6_RS01610	COG1438	arginine binding
MS6_RS01615	COG0039	L-malate dehydrogenase activity
MS6_RS01620	COG0531	amino acid
MS6_RS01625	COG0142	geranyltranstransferase activity
MS6_RS01630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MS6_RS01635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MS6_RS01640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MS6_RS01645	COG2966	Psort location CytoplasmicMembrane, score
MS6_RS01650	COG3610	response to peptide
MS6_RS01660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MS6_RS01665	COG2967	ApaG domain
MS6_RS01670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MS6_RS01675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MS6_RS01680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MS6_RS01685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MS6_RS01690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MS6_RS01720	COG0840	transmembrane signaling receptor activity
MS6_RS01745	COG0741	lytic transglycosylase activity
MS6_RS01750	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MS6_RS01755	COG1194	a g-specific adenine glycosylase
MS6_RS01760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MS6_RS01765	COG2066	Belongs to the glutaminase family
MS6_RS01770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MS6_RS01775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MS6_RS01790	COG0762	integral membrane protein
MS6_RS01795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MS6_RS01800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MS6_RS01820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MS6_RS01825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MS6_RS01830	COG1678	Uncharacterized ACR, COG1678
MS6_RS01835	COG0189	ligase activity
MS6_RS01840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MS6_RS01845	COG2356	endonuclease I
MS6_RS01855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MS6_RS01865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MS6_RS01870	COG0583	DNA-binding transcription factor activity
MS6_RS01875	COG4771	TonB-dependent receptor
MS6_RS01880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MS6_RS01885	COG0126	phosphoglycerate kinase activity
MS6_RS01890	COG0191	fructose-bisphosphate aldolase activity
MS6_RS01900	COG0668	transmembrane transport
MS6_RS01905	COG1279	arginine transmembrane transporter activity
MS6_RS01925	COG1349	DNA-binding transcription factor activity
MS6_RS01930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MS6_RS01935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MS6_RS01955	COG0358	DNA primase activity
MS6_RS01960	COG1610	YqeY-like protein
MS6_RS01965	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MS6_RS01970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MS6_RS01980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MS6_RS01985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MS6_RS01990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MS6_RS01995	COG1968	undecaprenyl-diphosphatase activity
MS6_RS02000	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MS6_RS02005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MS6_RS02010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MS6_RS02015	COG0585	pseudouridine synthase activity
MS6_RS02020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MS6_RS02025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MS6_RS02035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MS6_RS02040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MS6_RS02060	COG4208	sulfate ABC transporter
MS6_RS02065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MS6_RS02075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MS6_RS02080	COG2137	regulation of response to DNA damage stimulus
MS6_RS02085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MS6_RS02090	COG0527	aspartate kinase activity
MS6_RS02095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MS6_RS02145	COG3630	sodium ion export across plasma membrane
MS6_RS02150	COG5016	pyruvate
MS6_RS02150	COG0511	ligase activity, forming carbon-carbon bonds
MS6_RS02155	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MS6_RS02165	COG1238	metal cluster binding
MS6_RS02170	COG0612	Peptidase, M16
MS6_RS02175	COG2918	glutathione biosynthetic process
MS6_RS02180	COG1854	S-ribosylhomocysteine lyase activity
MS6_RS02185	COG4536	flavin adenine dinucleotide binding
MS6_RS02190	COG4137	Cytochrome C assembly protein
MS6_RS02195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MS6_RS02200	COG0228	four-way junction DNA binding
MS6_RS02205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MS6_RS02210	COG0336	Belongs to the RNA methyltransferase TrmD family
MS6_RS02215	COG0335	large ribosomal subunit rRNA binding
MS6_RS02220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MS6_RS02225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MS6_RS02235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MS6_RS02245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MS6_RS02250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MS6_RS02255	COG0723	plastoquinol--plastocyanin reductase activity
MS6_RS02260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MS6_RS02265	COG2857	Cytochrome c1
MS6_RS02270	COG0625	glutathione transferase activity
MS6_RS02275	COG2969	positive regulation of protein catabolic process
MS6_RS02280	COG2823	Periplasmic or secreted lipoprotein
MS6_RS02285	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MS6_RS02290	COG0792	nuclease activity
MS6_RS02295	COG3107	peptidoglycan biosynthetic process
MS6_RS02300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MS6_RS02315	COG0288	reversible hydration of carbon dioxide
MS6_RS02320	COG0659	secondary active sulfate transmembrane transporter activity
MS6_RS02325	COG1131	(ABC) transporter
MS6_RS02330	COG0842	Transport permease protein
MS6_RS02335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MS6_RS02340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MS6_RS02345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MS6_RS02355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MS6_RS02365	COG1489	DNA binding
MS6_RS02375	COG1643	Atp-dependent helicase
MS6_RS02380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MS6_RS02385	COG1752	Esterase of the alpha-beta hydrolase superfamily
MS6_RS02390	COG1049	propionate catabolic process, 2-methylcitrate cycle
MS6_RS02395	COG3112	Uncharacterised protein family (UPF0231)
MS6_RS02400	COG0347	Belongs to the P(II) protein family
MS6_RS02405	COG0004	ammonium transporteR
MS6_RS02410	COG1840	ABC-type Fe3 transport system, periplasmic component
MS6_RS02420	COG3842	ATPase activity
MS6_RS02440	COG2971	BadF BadG BcrA BcrD
MS6_RS02450	COG4608	Belongs to the ABC transporter superfamily
MS6_RS02455	COG0444	Belongs to the ABC transporter superfamily
MS6_RS02460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MS6_RS02465	COG0601	transmembrane transport
MS6_RS02470	COG0747	negative chemotaxis
MS6_RS02480	COG0784	Response regulator, receiver
MS6_RS02480	COG2205	protein histidine kinase activity
MS6_RS02485	COG2813	Specifically methylates the guanine in position
MS6_RS02490	COG0628	permease
MS6_RS02500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MS6_RS02510	COG0316	Belongs to the HesB IscA family
MS6_RS02525	COG0739	heme binding
MS6_RS02530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MS6_RS02535	COG2027	D-alanyl-D-alanine carboxypeptidase
MS6_RS02540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MS6_RS02545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MS6_RS02550	COG1534	Rna-binding protein
MS6_RS02555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MS6_RS02560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MS6_RS02565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MS6_RS02575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MS6_RS02590	COG0779	Required for maturation of 30S ribosomal subunits
MS6_RS02595	COG0195	Participates in both transcription termination and antitermination
MS6_RS02600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MS6_RS02605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MS6_RS02615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MS6_RS02640	COG0826	peptidase U32
MS6_RS02645	COG0826	peptidase U32
MS6_RS02655	COG3154	lipid carrier protein
MS6_RS02660	COG3153	acetyltransferase
MS6_RS02685	COG0513	Belongs to the DEAD box helicase family
MS6_RS02700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MS6_RS02705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MS6_RS02710	COG2204	response regulator
MS6_RS02720	COG0667	Aldo Keto reductase
MS6_RS02735	COG0494	nUDIX hydrolase
MS6_RS02740	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
MS6_RS02745	COG0730	response to heat
MS6_RS02750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MS6_RS02760	COG1283	sodium-dependent phosphate transmembrane transporter activity
MS6_RS02765	COG0583	DNA-binding transcription factor activity
MS6_RS02770	COG0640	Transcriptional regulator
MS6_RS02775	COG0268	Binds directly to 16S ribosomal RNA
MS6_RS02780	COG0728	peptidoglycan biosynthetic process
MS6_RS02785	COG0196	riboflavin kinase activity
MS6_RS02800	COG1047	Peptidyl-prolyl cis-trans
MS6_RS02805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MS6_RS02810	COG1966	Carbon starvation protein
MS6_RS02825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MS6_RS02830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MS6_RS02840	COG3279	Response regulator of the LytR AlgR family
MS6_RS02845	COG3275	phosphorelay sensor kinase activity
MS6_RS02850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MS6_RS02855	COG0287	Prephenate dehydrogenase
MS6_RS02855	COG1605	Chorismate mutase
MS6_RS02865	COG0488	(ABC) transporter
MS6_RS02875	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
MS6_RS02885	COG5001	Diguanylate cyclase
MS6_RS02890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MS6_RS02895	COG0077	Prephenate dehydratase
MS6_RS02895	COG1605	Chorismate mutase
MS6_RS02900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MS6_RS02905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MS6_RS02910	COG0564	pseudouridine synthase activity
MS6_RS02920	COG0542	response to heat
MS6_RS02960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MS6_RS02965	COG0826	peptidase U32
MS6_RS02975	COG0745	RESPONSE REGULATOR receiver
MS6_RS02980	COG5002	protein histidine kinase activity
MS6_RS02990	COG0248	Ppx GppA phosphatase
MS6_RS02995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MS6_RS03005	COG0581	inorganic phosphate transmembrane transporter activity
MS6_RS03010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MS6_RS03025	COG3142	Participates in the control of copper homeostasis
MS6_RS03030	COG0450	alkyl hydroperoxide reductase
MS6_RS03035	COG0583	DNA-binding transcription factor activity
MS6_RS03040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MS6_RS03050	COG0517	IMP dehydrogenase activity
MS6_RS03070	COG1862	Preprotein translocase
MS6_RS03075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MS6_RS03080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MS6_RS03085	COG0483	inositol monophosphate 1-phosphatase activity
MS6_RS03095	COG1959	2 iron, 2 sulfur cluster binding
MS6_RS03100	COG1104	cysteine desulfurase activity
MS6_RS03105	COG0822	iron-sulfur transferase activity
MS6_RS03115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MS6_RS03120	COG0443	Heat shock 70 kDa protein
MS6_RS03125	COG0633	Ferredoxin
MS6_RS03130	COG2975	iron-sulfur cluster assembly
MS6_RS03135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MS6_RS03140	COG0105	UTP biosynthetic process
MS6_RS03145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MS6_RS03155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MS6_RS03160	COG0124	histidyl-tRNA synthetase
MS6_RS03165	COG2976	Protein conserved in bacteria
MS6_RS03170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MS6_RS03175	COG1160	GTP binding
MS6_RS03190	COG1570	exodeoxyribonuclease VII activity
MS6_RS03195	COG0517	IMP dehydrogenase activity
MS6_RS03195	COG0516	GMP reductase activity
MS6_RS03200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MS6_RS03200	COG0519	Catalyzes the synthesis of GMP from XMP
MS6_RS03210	COG1584	GPR1 FUN34 yaaH family protein
MS6_RS03215	COG3433	isochorismatase activity
MS6_RS03215	COG1535	isochorismatase
MS6_RS03220	COG1021	2,3-dihydroxybenzoate-AMP ligase
MS6_RS03225	COG1169	isochorismate synthase
MS6_RS03230	COG1028	Short-chain dehydrogenase reductase Sdr
MS6_RS03240	COG4592	Periplasmic binding protein
MS6_RS03245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MS6_RS03250	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MS6_RS03255	COG1120	ATPase activity
MS6_RS03265	COG0583	DNA-binding transcription factor activity
MS6_RS03270	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MS6_RS03275	COG1115	amino acid carrier protein
MS6_RS03285	COG0583	DNA-binding transcription factor activity
MS6_RS03300	COG4565	transcriptional regulatory protein
MS6_RS03310	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MS6_RS03315	COG0511	ligase activity, forming carbon-carbon bonds
MS6_RS03315	COG5016	pyruvate
MS6_RS03320	COG3630	sodium ion export across plasma membrane
MS6_RS03330	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
MS6_RS03340	COG2301	Belongs to the HpcH HpaI aldolase family
MS6_RS03345	COG3051	citrate lyase alpha subunit
MS6_RS03365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MS6_RS03370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MS6_RS03375	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MS6_RS03445	COG1012	belongs to the aldehyde dehydrogenase family
MS6_RS03465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MS6_RS03470	COG0840	transmembrane signaling receptor activity
MS6_RS03475	COG3710	Transcriptional regulator
MS6_RS03485	COG2165	general secretion pathway protein
MS6_RS03500	COG4796	Type ii and iii secretion system protein
MS6_RS03520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_RS03525	COG1459	type II secretion system
MS6_RS03535	COG2207	Transcriptional regulator
MS6_RS03540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MS6_RS03560	COG0739	heme binding
MS6_RS03570	COG3064	Membrane
MS6_RS03580	COG0582	viral genome integration into host DNA
MS6_RS03585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MS6_RS03590	COG2867	negative regulation of translational initiation
MS6_RS03595	COG2914	Belongs to the UPF0125 (RnfH) family
MS6_RS03600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MS6_RS03605	COG0497	DNA recombination
MS6_RS03610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MS6_RS03615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MS6_RS03620	COG0443	Heat shock 70 kDa protein
MS6_RS03625	COG0484	heat shock protein binding
MS6_RS03660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MS6_RS03675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MS6_RS03685	COG0047	phosphoribosylformylglycinamidine synthase activity
MS6_RS03685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MS6_RS03715	COG0442	prolyl-tRNA aminoacylation
MS6_RS03720	COG1720	tRNA m6t6A37 methyltransferase activity
MS6_RS03725	COG0254	rRNA binding
MS6_RS03730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MS6_RS03735	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MS6_RS03740	COG1671	Belongs to the UPF0178 family
MS6_RS03750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_RS03765	COG3098	single-species biofilm formation
MS6_RS03770	COG0564	pseudouridine synthase activity
MS6_RS03775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MS6_RS03780	COG0142	geranyltranstransferase activity
MS6_RS03785	COG1722	exodeoxyribonuclease VII activity
MS6_RS03790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MS6_RS03800	COG0301	tRNA thio-modification
MS6_RS03800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MS6_RS03810	COG0583	DNA-binding transcription factor activity
MS6_RS03815	COG2363	Small membrane protein
MS6_RS03820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MS6_RS03825	COG1611	Belongs to the LOG family
MS6_RS03840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MS6_RS03840	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MS6_RS03850	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
MS6_RS03855	COG1464	Belongs to the NlpA lipoprotein family
MS6_RS03860	COG2011	ABC-type metal ion transport system permease component
MS6_RS03865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MS6_RS03870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MS6_RS03875	COG1609	Transcriptional regulator
MS6_RS03880	COG1263	PTS System
MS6_RS03880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_RS03885	COG0366	Alpha amylase catalytic
MS6_RS03905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_RS03910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MS6_RS03915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MS6_RS03920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MS6_RS03925	COG0110	maltose O-acetyltransferase activity
MS6_RS03945	COG1045	serine acetyltransferase
MS6_RS03955	COG0438	transferase activity, transferring glycosyl groups
MS6_RS03965	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MS6_RS03995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MS6_RS04005	COG1596	polysaccharide export
MS6_RS04030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MS6_RS04040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MS6_RS04045	COG0321	lipoyl(octanoyl) transferase activity
MS6_RS04050	COG2921	Belongs to the UPF0250 family
MS6_RS04060	COG1686	Belongs to the peptidase S11 family
MS6_RS04065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MS6_RS04070	COG0772	Belongs to the SEDS family
MS6_RS04075	COG0768	penicillin binding
MS6_RS04080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MS6_RS04085	COG0799	negative regulation of ribosome biogenesis
MS6_RS04090	COG1466	dna polymerase III delta subunit
MS6_RS04095	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MS6_RS04100	COG0495	leucyl-tRNA aminoacylation
MS6_RS04105	COG2888	peptidyl-tyrosine sulfation
MS6_RS04110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MS6_RS04115	COG4535	Mg2 and Co2 transporter CorC
MS6_RS04125	COG1702	phosphate starvation-inducible protein PhoH
MS6_RS04130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MS6_RS04135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_RS04140	COG2190	(PTS) system
MS6_RS04150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_RS04160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MS6_RS04165	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MS6_RS04170	COG3115	cell septum assembly
MS6_RS04175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MS6_RS04190	COG0789	Transcriptional regulator
MS6_RS04195	COG1585	Membrane protein implicated in regulation of membrane protease activity
MS6_RS04200	COG0330	HflC and HflK could
MS6_RS04205	COG3118	belongs to the thioredoxin family
MS6_RS04210	COG0300	oxidoreductase activity
MS6_RS04215	COG1090	epimerase
MS6_RS04220	COG0622	Phosphoesterase
MS6_RS04235	COG3710	Transcriptional regulator
MS6_RS04240	COG0326	Molecular chaperone. Has ATPase activity
MS6_RS04245	COG0563	adenylate kinase activity
MS6_RS04250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MS6_RS04265	COG0367	asparagine synthase
MS6_RS04270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MS6_RS04270	COG4651	solute:proton antiporter activity
MS6_RS04275	COG1846	Transcriptional regulator
MS6_RS04275	COG1940	carbohydrate kinase activity
MS6_RS04280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MS6_RS04285	COG2190	(PTS) system
MS6_RS04285	COG1263	PTS System
MS6_RS04285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_RS04300	COG0101	tRNA pseudouridine synthase activity
MS6_RS04305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MS6_RS04310	COG0285	dihydrofolate synthase activity
MS6_RS04315	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MS6_RS04320	COG1286	toxin biosynthetic process
MS6_RS04325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MS6_RS04330	COG2056	Na+-H+ antiporter family
MS6_RS04335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MS6_RS04355	COG0346	lactoylglutathione lyase activity
MS6_RS04360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MS6_RS04380	COG4656	Part of a membrane complex involved in electron transport
MS6_RS04385	COG2878	Part of a membrane complex involved in electron transport
MS6_RS04390	COG4657	Part of a membrane complex involved in electron transport
MS6_RS04400	COG0556	nucleotide-excision repair
MS6_RS04410	COG2204	response regulator
MS6_RS04415	COG2198	Histidine kinase
MS6_RS04420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MS6_RS04425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MS6_RS04430	COG0521	Mo-molybdopterin cofactor biosynthetic process
MS6_RS04435	COG0315	cyclic pyranopterin monophosphate synthase activity
MS6_RS04440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MS6_RS04445	COG0314	molybdopterin synthase activity
MS6_RS04450	COG2199	diguanylate cyclase activity
MS6_RS04455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MS6_RS04455	COG0617	tRNA 3'-terminal CCA addition
MS6_RS04455	COG0517	IMP dehydrogenase activity
MS6_RS04470	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MS6_RS04480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_RS04480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_RS04485	COG0489	protein tyrosine kinase activity
MS6_RS04495	COG0572	uridine kinase
MS6_RS04500	COG2982	Protein involved in outer membrane biogenesis
MS6_RS04505	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MS6_RS04510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MS6_RS04520	COG2067	long-chain fatty acid transport protein
MS6_RS04535	COG0183	Belongs to the thiolase family
MS6_RS04540	COG1024	Enoyl-CoA hydratase
MS6_RS04540	COG1250	3-hydroxyacyl-CoA dehydrogenase
MS6_RS04545	COG0778	Nitroreductase
MS6_RS04550	COG0583	DNA-binding transcription factor activity
MS6_RS04555	COG0745	RESPONSE REGULATOR receiver
MS6_RS04565	COG2832	Protein of unknown function (DUF454)
MS6_RS04570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MS6_RS04580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MS6_RS04585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MS6_RS04595	COG2983	Belongs to the UPF0260 family
MS6_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
MS6_RS04605	COG0616	signal peptide processing
MS6_RS04615	COG1522	sequence-specific DNA binding
MS6_RS04620	COG1946	Acyl-CoA thioesterase
MS6_RS04640	COG3706	GGDEF domain
MS6_RS04645	COG0640	Transcriptional regulator
MS6_RS04650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MS6_RS04675	COG1881	PFAM PEBP family protein
MS6_RS04695	COG0009	L-threonylcarbamoyladenylate synthase
MS6_RS04710	COG2201	protein-glutamate methylesterase activity
MS6_RS04720	COG5002	protein histidine kinase activity
MS6_RS04725	COG4191	Histidine kinase
MS6_RS04730	COG3300	MHYT domain
MS6_RS04730	COG5001	Diguanylate cyclase
MS6_RS04735	COG2204	response regulator
MS6_RS04755	COG0601	transmembrane transport
MS6_RS04760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MS6_RS04765	COG0444	Belongs to the ABC transporter superfamily
MS6_RS04770	COG4608	Belongs to the ABC transporter superfamily
MS6_RS04775	COG0435	Glutathione S-transferase
MS6_RS04780	COG0280	phosphate acetyltransferase
MS6_RS04780	COG0857	belongs to the CobB CobQ family
MS6_RS04785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MS6_RS04790	COG3092	negative regulation of chromosome organization
MS6_RS04795	COG4628	conserved protein (DUF2132)
MS6_RS04805	COG4120	Belongs to the binding-protein-dependent transport system permease family
MS6_RS04815	COG2203	Gaf domain
MS6_RS04815	COG2199	diguanylate cyclase activity
MS6_RS04820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MS6_RS04830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MS6_RS04835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MS6_RS04840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MS6_RS04845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MS6_RS04850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MS6_RS04855	COG0156	8-amino-7-oxononanoate synthase activity
MS6_RS04860	COG2226	methyltransferase
MS6_RS04865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MS6_RS04875	COG0501	Belongs to the peptidase M48B family
MS6_RS04885	COG0300	oxidoreductase activity
MS6_RS04900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MS6_RS04910	COG2268	Band 7 protein
MS6_RS04920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MS6_RS04925	COG2915	High frequency lysogenization protein hflD homolog
MS6_RS04930	COG0482	sulfurtransferase activity
MS6_RS04935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MS6_RS04940	COG2916	Histone family protein nucleoid-structuring protein H-NS
MS6_RS04945	COG1757	Na H antiporter
MS6_RS04950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MS6_RS04955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MS6_RS04960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MS6_RS04965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MS6_RS04965	COG0131	Imidazoleglycerol-phosphate dehydratase
MS6_RS04970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MS6_RS04975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MS6_RS04980	COG0107	imidazoleglycerol-phosphate synthase activity
MS6_RS04985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MS6_RS04985	COG0140	phosphoribosyl-ATP diphosphatase activity
MS6_RS04990	COG1187	pseudouridine synthase activity
MS6_RS05000	COG1278	Cold shock
MS6_RS05005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MS6_RS05010	COG0542	response to heat
MS6_RS05015	COG2985	domain, Protein
MS6_RS05015	COG3273	potassium ion transport
MS6_RS05020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MS6_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
MS6_RS05025	COG1454	alcohol dehydrogenase
MS6_RS05030	COG1737	Transcriptional regulator
MS6_RS05035	COG0076	glutamate decarboxylase activity
MS6_RS05045	COG2431	L-lysine efflux transmembrane transporter activity
MS6_RS05055	COG3070	regulator of competence-specific genes
MS6_RS05070	COG3852	Histidine kinase
MS6_RS05080	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MS6_RS05095	COG0189	ligase activity
MS6_RS05095	COG4067	protein conserved in archaea
MS6_RS05100	COG0500	methyltransferase
MS6_RS05105	COG4106	trans-aconitate 2-methyltransferase activity
MS6_RS05110	COG1801	Protein of unknown function DUF72
MS6_RS05115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MS6_RS05120	COG1435	thymidine kinase activity
MS6_RS05130	COG0159	tryptophan synthase activity
MS6_RS05135	COG0133	tryptophan synthase activity
MS6_RS05140	COG0135	phosphoribosylanthranilate isomerase activity
MS6_RS05140	COG0134	indole-3-glycerol-phosphate synthase activity
MS6_RS05145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MS6_RS05150	COG0512	Glutamine amidotransferase of anthranilate synthase
MS6_RS05155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MS6_RS05165	COG0613	PHP domain protein
MS6_RS05170	COG0009	L-threonylcarbamoyladenylate synthase
MS6_RS05175	COG1187	pseudouridine synthase activity
MS6_RS05180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MS6_RS05185	COG4988	ABC transporter
MS6_RS05190	COG0492	ferredoxin-NADP+ reductase activity
MS6_RS05200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MS6_RS05210	COG2949	membrane
MS6_RS05220	COG0281	malic enzyme
MS6_RS05230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MS6_RS05250	COG2885	chlorophyll binding
MS6_RS05265	COG0277	FAD linked oxidase domain protein
MS6_RS05265	COG0247	lactate metabolic process
MS6_RS05285	COG2986	histidine ammonia-lyase
MS6_RS05290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MS6_RS05295	COG0010	Belongs to the arginase family
MS6_RS05300	COG1228	amidohydrolase
MS6_RS05315	COG3099	Belongs to the UPF0263 family
MS6_RS05320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MS6_RS05330	COG5001	Diguanylate cyclase
MS6_RS05335	COG0417	DNA replication proofreading
MS6_RS05340	COG2197	response regulator
MS6_RS05345	COG0322	excinuclease ABC activity
MS6_RS05385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MS6_RS05390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_RS05390	COG0072	phenylalanine-tRNA ligase activity
MS6_RS05395	COG0776	regulation of translation
MS6_RS05435	COG1346	cytolysis
MS6_RS05440	COG1380	Effector of murein hydrolase LrgA
MS6_RS05445	COG2925	Exonuclease
MS6_RS05450	COG1823	symporter activity
MS6_RS05455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_RS05460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MS6_RS05465	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MS6_RS05485	COG4139	cobalamin transport
MS6_RS05535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MS6_RS05540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MS6_RS05545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MS6_RS05555	COG1054	Belongs to the UPF0176 family
MS6_RS05565	COG2814	Major facilitator Superfamily
MS6_RS05575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MS6_RS05600	COG2989	Protein conserved in bacteria
MS6_RS05605	COG3108	Peptidase M15
MS6_RS05610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MS6_RS05625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MS6_RS05650	COG1846	Transcriptional regulator
MS6_RS05655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MS6_RS05660	COG0726	polysaccharide deacetylase
MS6_RS05665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MS6_RS05675	COG1447	Phosphotransferase system cellobiose-specific component IIA
MS6_RS05680	COG1486	melibiose metabolic process
MS6_RS05690	COG1609	Transcriptional regulator
MS6_RS05695	COG2943	transferase activity, transferring hexosyl groups
MS6_RS05700	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MS6_RS05705	COG0840	transmembrane signaling receptor activity
MS6_RS05720	COG1448	Aminotransferase
MS6_RS05730	COG3437	response regulator, receiver
MS6_RS05730	COG2770	Histidine kinase
MS6_RS05735	COG0351	phosphomethylpyrimidine kinase
MS6_RS05740	COG0017	Asparaginyl-tRNA synthetase
MS6_RS05745	COG0840	transmembrane signaling receptor activity
MS6_RS05750	COG0720	synthase
MS6_RS05755	COG1760	l-serine dehydratase
MS6_RS05760	COG0814	amino acid
MS6_RS05765	COG0494	nUDIX hydrolase
MS6_RS05770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MS6_RS05785	COG3106	COG3106 Predicted ATPase
MS6_RS05790	COG3768	UPF0283 membrane protein
MS6_RS05800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MS6_RS05815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MS6_RS05825	COG0471	metal ion transport
MS6_RS05830	COG4191	Histidine kinase
MS6_RS05830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MS6_RS05840	COG2990	Protein conserved in bacteria
MS6_RS05845	COG3713	MltA-interacting MipA family protein
MS6_RS05850	COG2205	protein histidine kinase activity
MS6_RS05855	COG0745	RESPONSE REGULATOR receiver
MS6_RS05890	COG1129	ABC transporter
MS6_RS05930	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MS6_RS05935	COG0372	Belongs to the citrate synthase family
MS6_RS05965	COG2195	Cleaves the N-terminal amino acid of tripeptides
MS6_RS05975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MS6_RS05985	COG0625	glutathione transferase activity
MS6_RS05990	COG3437	response regulator, receiver
MS6_RS05995	COG4999	Histidine kinase
MS6_RS05995	COG3850	Histidine kinase
MS6_RS05995	COG3437	response regulator, receiver
MS6_RS05995	COG2205	protein histidine kinase activity
MS6_RS06010	COG3706	GGDEF domain
MS6_RS06015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MS6_RS06020	COG1254	Belongs to the acylphosphatase family
MS6_RS06025	COG2920	part of a sulfur-relay system
MS6_RS06030	COG0670	Belongs to the BI1 family
MS6_RS06035	COG1126	abc transporter atp-binding protein
MS6_RS06040	COG0765	amino acid transport
MS6_RS06045	COG4597	amino acid ABC transporter
MS6_RS06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MS6_RS06060	COG0561	phosphatase activity
MS6_RS06065	COG0602	queuosine metabolic process
MS6_RS06070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MS6_RS06105	COG0443	Heat shock 70 kDa protein
MS6_RS06150	COG1643	Atp-dependent helicase
MS6_RS06160	COG0443	Heat shock 70 kDa protein
MS6_RS06165	COG0095	Lipoate-protein ligase
MS6_RS06175	COG0583	DNA-binding transcription factor activity
MS6_RS06180	COG0477	Major facilitator Superfamily
MS6_RS06185	COG0415	Belongs to the DNA photolyase family
MS6_RS06200	COG0745	RESPONSE REGULATOR receiver
MS6_RS06210	COG0643	Histidine kinase
MS6_RS06210	COG2198	Histidine kinase
MS6_RS06215	COG0643	Histidine kinase
MS6_RS06215	COG2198	Histidine kinase
MS6_RS06215	COG0784	Response regulator, receiver
MS6_RS06220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MS6_RS06230	COG2201	protein-glutamate methylesterase activity
MS6_RS06235	COG0835	chemotaxis
MS6_RS06240	COG0840	transmembrane signaling receptor activity
MS6_RS06240	COG3290	protein histidine kinase activity
MS6_RS06245	COG0840	transmembrane signaling receptor activity
MS6_RS06255	COG0513	Belongs to the DEAD box helicase family
MS6_RS06265	COG1538	Outer membrane efflux protein
MS6_RS06270	COG1566	PFAM secretion protein HlyD family protein
MS6_RS06275	COG2814	Major facilitator Superfamily
MS6_RS06285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MS6_RS06295	COG3501	Rhs element vgr protein
MS6_RS06305	COG3675	Pfam Lipase (class 3)
MS6_RS06320	COG1280	lysine exporter protein (LysE YggA)
MS6_RS06325	COG1115	amino acid carrier protein
MS6_RS06340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MS6_RS06350	COG1177	transmembrane transport
MS6_RS06360	COG3842	ATPase activity
MS6_RS06385	COG0589	response to stress
MS6_RS06390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MS6_RS06405	COG2217	Heavy metal translocating P-type atpase
MS6_RS06415	COG2010	Cytochrome c
MS6_RS06430	COG3278	Belongs to the heme-copper respiratory oxidase family
MS6_RS06445	COG2205	protein histidine kinase activity
MS6_RS06445	COG0784	Response regulator, receiver
MS6_RS06470	COG2994	toxin metabolic process
MS6_RS06475	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
MS6_RS06475	COG1073	alpha beta
MS6_RS06475	COG3064	Membrane
MS6_RS06515	COG4128	Pfam Zonular occludens toxin
MS6_RS06545	COG1476	TRANSCRIPTIONal
MS6_RS06560	COG4128	Pfam Zonular occludens toxin
MS6_RS06590	COG1476	TRANSCRIPTIONal
MS6_RS06675	COG3120	sequence-specific DNA binding
MS6_RS06680	COG1067	ATP-dependent peptidase activity
MS6_RS06685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MS6_RS06700	COG0488	(ABC) transporter
MS6_RS06710	COG0116	Belongs to the methyltransferase superfamily
MS6_RS06710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MS6_RS06720	COG0167	dihydroorotate dehydrogenase activity
MS6_RS06735	COG0308	aminopeptidase N
MS6_RS06750	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MS6_RS06755	COG1956	GAF domain-containing protein
MS6_RS06760	COG1132	(ABC) transporter
MS6_RS06765	COG2995	paraquat-inducible protein a
MS6_RS06770	COG3008	intermembrane lipid transfer
MS6_RS06780	COG2996	Protein conserved in bacteria
MS6_RS06795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MS6_RS06800	COG1666	GTP binding
MS6_RS06805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MS6_RS06820	COG0437	4 iron, 4 sulfur cluster binding
MS6_RS06825	COG0243	molybdopterin cofactor binding
MS6_RS06825	COG3383	formate dehydrogenase (NAD+) activity
MS6_RS06855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MS6_RS06860	COG0488	(ABC) transporter
MS6_RS06865	COG3852	Histidine kinase
MS6_RS06870	COG2204	response regulator
MS6_RS06880	COG4662	Binding-protein-dependent transport system inner membrane component
MS6_RS06885	COG3842	ATPase activity
MS6_RS06890	COG0746	molybdenum cofactor guanylyltransferase activity
MS6_RS06895	COG0303	'Molybdopterin
MS6_RS06920	COG1940	carbohydrate kinase activity
MS6_RS06925	COG3148	PFAM DTW domain containing protein
MS6_RS06935	COG0840	transmembrane signaling receptor activity
MS6_RS06940	COG0791	NLP P60 protein
MS6_RS06950	COG3001	Fructosamine kinase
MS6_RS06960	COG0534	Mate efflux family protein
MS6_RS06970	COG1793	dna ligase
MS6_RS06980	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MS6_RS06985	COG0848	biopolymer transport protein
MS6_RS06990	COG0811	peptide transport
MS6_RS06995	COG0811	peptide transport
MS6_RS07010	COG1175	transmembrane transport
MS6_RS07015	COG0395	ABC-type sugar transport system, permease component
MS6_RS07020	COG3842	ATPase activity
MS6_RS07025	COG1349	DNA-binding transcription factor activity
MS6_RS07030	COG0584	glycerophosphoryl diester phosphodiesterase
MS6_RS07035	COG2731	YhcH YjgK YiaL family protein
MS6_RS07040	COG0251	oxidation-reduction process
MS6_RS07045	COG1609	Transcriptional regulator
MS6_RS07050	COG2723	6-phospho-beta-galactosidase activity
MS6_RS07060	COG0583	DNA-binding transcription factor activity
MS6_RS07080	COG0577	efflux transmembrane transporter activity
MS6_RS07080	COG1136	(ABC) transporter
MS6_RS07085	COG0577	efflux transmembrane transporter activity
MS6_RS07085	COG1136	(ABC) transporter
MS6_RS07090	COG1136	(ABC) transporter
MS6_RS07090	COG4591	ABC-type transport system involved in lipoprotein release permease component
MS6_RS07095	COG1294	oxidase, subunit
MS6_RS07100	COG1271	oxidase subunit
MS6_RS07140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MS6_RS07150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MS6_RS07170	COG0753	catalase activity
MS6_RS07185	COG3527	Alpha-acetolactate decarboxylase
MS6_RS07200	COG2200	EAL domain
MS6_RS07200	COG2199	diguanylate cyclase activity
MS6_RS07210	COG2017	converts alpha-aldose to the beta-anomer
MS6_RS07215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MS6_RS07220	COG1085	galactose-1-phosphate uridylyltransferase
MS6_RS07260	COG0835	chemotaxis
MS6_RS07260	COG0784	Response regulator, receiver
MS6_RS07270	COG4565	transcriptional regulatory protein
MS6_RS07275	COG3290	protein histidine kinase activity
MS6_RS07290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_RS07310	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MS6_RS07315	COG3063	Type IV pilus biogenesis stability protein PilW
MS6_RS07330	COG1451	nucleotide metabolic process
MS6_RS07340	COG0583	DNA-binding transcription factor activity
MS6_RS07360	COG1538	Outer membrane efflux protein
MS6_RS07375	COG1748	Saccharopine dehydrogenase
MS6_RS07385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MS6_RS07395	COG0577	efflux transmembrane transporter activity
MS6_RS07400	COG4181	ATPase activity
MS6_RS07405	COG0534	Mate efflux family protein
MS6_RS07410	COG0702	epimerase
MS6_RS07420	COG2814	Major facilitator Superfamily
MS6_RS07425	COG1187	pseudouridine synthase activity
MS6_RS07430	COG1061	Type III restriction enzyme res subunit
MS6_RS07450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MS6_RS07455	COG4251	negative regulation of phosphorylation
MS6_RS07455	COG5001	Diguanylate cyclase
MS6_RS07455	COG3706	GGDEF domain
MS6_RS07455	COG2203	Gaf domain
MS6_RS07470	COG0840	transmembrane signaling receptor activity
MS6_RS07500	COG4934	collagen metabolic process
MS6_RS07515	COG0784	Response regulator, receiver
MS6_RS07515	COG2205	protein histidine kinase activity
MS6_RS07520	COG2239	Acts as a magnesium transporter
MS6_RS07530	COG0814	amino acid
MS6_RS07535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_RS07540	COG1131	(ABC) transporter
MS6_RS07545	COG0842	Transport permease protein
MS6_RS07555	COG3313	Fe-S protein
MS6_RS07565	COG4134	Bacterial extracellular solute-binding protein
MS6_RS07570	COG4135	transport system, permease component
MS6_RS07575	COG4136	ATPase activity
MS6_RS07580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MS6_RS07585	COG0564	pseudouridine synthase activity
MS6_RS07590	COG0733	neurotransmitter:sodium symporter activity
MS6_RS07600	COG0626	cystathionine gamma-synthase activity
MS6_RS07605	COG2818	Glycosylase
MS6_RS07620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_RS07635	COG1842	Phage shock protein A
MS6_RS07640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MS6_RS07650	COG4168	peptide transport system, permease
MS6_RS07665	COG4172	Belongs to the ABC transporter superfamily
MS6_RS07680	COG1227	inorganic diphosphatase activity
MS6_RS07695	COG0243	molybdopterin cofactor binding
MS6_RS07700	COG3005	denitrification pathway
MS6_RS07705	COG4459	periplasmic nitrate reductase
MS6_RS07715	COG2116	formate transmembrane transporter activity
MS6_RS07725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MS6_RS07730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MS6_RS07745	COG1607	acyl-coa hydrolase
MS6_RS07750	COG2350	Protein conserved in bacteria
MS6_RS07760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MS6_RS07765	COG0583	DNA-binding transcription factor activity
MS6_RS07780	COG0612	Peptidase, M16
MS6_RS07785	COG5001	Diguanylate cyclase
MS6_RS07790	COG1032	radical SAM domain protein
MS6_RS07810	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MS6_RS07820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MS6_RS07825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MS6_RS07830	COG0745	RESPONSE REGULATOR receiver
MS6_RS07840	COG1609	Transcriptional regulator
MS6_RS07845	COG3070	regulator of competence-specific genes
MS6_RS07865	COG0297	glycogen (starch) synthase activity
MS6_RS07870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MS6_RS07875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MS6_RS07895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MS6_RS07900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MS6_RS07905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MS6_RS07910	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MS6_RS07915	COG1960	acyl-CoA dehydrogenase activity
MS6_RS07935	COG1012	belongs to the aldehyde dehydrogenase family
MS6_RS07940	COG1309	transcriptional regulator
MS6_RS07965	COG0668	transmembrane transport
MS6_RS07970	COG2995	paraquat-inducible protein a
MS6_RS07975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MS6_RS07975	COG3008	intermembrane lipid transfer
MS6_RS07985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MS6_RS07990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_RS08000	COG0582	viral genome integration into host DNA
MS6_RS08010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MS6_RS08030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MS6_RS08050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MS6_RS08070	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
MS6_RS08075	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
MS6_RS08080	COG1737	Transcriptional regulator
MS6_RS08085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MS6_RS08090	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MS6_RS08095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MS6_RS08100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MS6_RS08115	COG1940	carbohydrate kinase activity
MS6_RS08120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MS6_RS08125	COG4409	exo-alpha-(2->6)-sialidase activity
MS6_RS08135	COG2003	Belongs to the UPF0758 family
MS6_RS08155	COG3941	tape measure
MS6_RS08195	COG0488	(ABC) transporter
MS6_RS08270	COG0415	Belongs to the DNA photolyase family
MS6_RS08280	COG4628	conserved protein (DUF2132)
MS6_RS08285	COG3284	Transcriptional regulator
MS6_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
MS6_RS08300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_RS08305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_RS08310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_RS08320	COG2207	Transcriptional regulator
MS6_RS08325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_RS08325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_RS08325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MS6_RS08330	COG1482	cell wall glycoprotein biosynthetic process
MS6_RS08340	COG5002	protein histidine kinase activity
MS6_RS08340	COG0784	Response regulator, receiver
MS6_RS08350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MS6_RS08360	COG2885	chlorophyll binding
MS6_RS08365	COG0823	Involved in the tonB-independent uptake of proteins
MS6_RS08380	COG0811	peptide transport
MS6_RS08385	COG0824	Thioesterase
MS6_RS08390	COG3790	cyd operon protein YbgE
MS6_RS08395	COG4890	Cyd operon protein YbgT
MS6_RS08400	COG1294	oxidase, subunit
MS6_RS08405	COG1271	oxidase subunit
MS6_RS08415	COG0632	four-way junction helicase activity
MS6_RS08420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MS6_RS08425	COG0215	cysteine-tRNA ligase activity
MS6_RS08430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MS6_RS08435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_RS08440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MS6_RS08445	COG3012	SEC-C Motif Domain Protein
MS6_RS08450	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MS6_RS08455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MS6_RS08460	COG1199	ATP-dependent helicase activity
MS6_RS08465	COG0730	response to heat
MS6_RS08470	COG3923	Primosomal replication protein n
MS6_RS08480	COG0840	transmembrane signaling receptor activity
MS6_RS08485	COG0708	Exodeoxyribonuclease III
MS6_RS08490	COG4160	amino acid transport
MS6_RS08515	COG1882	Formate acetyltransferase
MS6_RS08525	COG0840	transmembrane signaling receptor activity
MS6_RS08530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MS6_RS08540	COG3013	Belongs to the UPF0304 family
MS6_RS08545	COG2766	serine protein kinase
MS6_RS08550	COG2718	Belongs to the UPF0229 family
MS6_RS08555	COG2719	SpoVR family
MS6_RS08560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MS6_RS08565	COG2835	tetraacyldisaccharide 4'-kinase activity
MS6_RS08570	COG1663	tetraacyldisaccharide 4'-kinase activity
MS6_RS08575	COG1132	(ABC) transporter
MS6_RS08580	COG0658	competence protein
MS6_RS08580	COG2333	competence protein COMEC
MS6_RS08590	COG4591	ABC-type transport system involved in lipoprotein release permease component
MS6_RS08595	COG1136	(ABC) transporter
MS6_RS08600	COG4591	ABC-type transport system involved in lipoprotein release permease component
MS6_RS08610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MS6_RS08630	COG1252	NADH dehydrogenase
MS6_RS08635	COG3150	esterase
MS6_RS08660	COG0537	adenosine 5'-monophosphoramidase activity
MS6_RS08680	COG2186	Transcriptional regulator
MS6_RS08685	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MS6_RS08690	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MS6_RS08695	COG1674	ftsk spoiiie
MS6_RS08705	COG0686	Belongs to the AlaDH PNT family
MS6_RS08715	COG0583	DNA-binding transcription factor activity
MS6_RS08735	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MS6_RS08740	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
MS6_RS08745	COG0776	regulation of translation
MS6_RS08750	COG0539	negative regulation of cytoplasmic translation
MS6_RS08755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MS6_RS08760	COG1555	photosystem II stabilization
MS6_RS08765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MS6_RS08770	COG0776	regulation of translation
MS6_RS08775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MS6_RS08780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MS6_RS08790	COG0544	peptidyl-prolyl cis-trans isomerase activity
MS6_RS08800	COG4191	Histidine kinase
MS6_RS08810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MS6_RS08815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MS6_RS08820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MS6_RS08825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MS6_RS08840	COG5001	Diguanylate cyclase
MS6_RS08840	COG3300	MHYT domain
MS6_RS08850	COG4589	Belongs to the CDS family
MS6_RS08885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MS6_RS08900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_RS08915	COG0243	molybdopterin cofactor binding
MS6_RS08920	COG3005	denitrification pathway
MS6_RS08925	COG3469	chitinase activity
MS6_RS08925	COG3325	Belongs to the glycosyl hydrolase 18 family
MS6_RS08930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MS6_RS08940	COG2951	lytic endotransglycosylase activity
MS6_RS08945	COG3100	YcgL domain-containing protein
MS6_RS08950	COG0850	regulation of cytokinetic process
MS6_RS08955	COG2894	cell division
MS6_RS08960	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MS6_RS08965	COG3015	lipoprotein NlpE involved in copper resistance
MS6_RS08985	COG0477	Major facilitator Superfamily
MS6_RS08995	COG0840	transmembrane signaling receptor activity
MS6_RS09000	COG1396	sequence-specific DNA binding
MS6_RS09005	COG3135	benzoate transporter
MS6_RS09025	COG0596	Alpha beta hydrolase
MS6_RS09030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MS6_RS09035	COG1169	isochorismate synthase
MS6_RS09040	COG0436	Aminotransferase
MS6_RS09045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MS6_RS09050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MS6_RS09070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MS6_RS09075	COG0318	PFAM AMP-dependent synthetase and ligase
MS6_RS09080	COG0596	Alpha beta hydrolase
MS6_RS09095	COG1214	PFAM Peptidase M22, glycoprotease
MS6_RS09100	COG1199	ATP-dependent helicase activity
MS6_RS09110	COG0788	formyltetrahydrofolate deformylase activity
MS6_RS09115	COG1902	pentaerythritol trinitrate reductase activity
MS6_RS09115	COG0446	pyridine nucleotide-disulphide oxidoreductase
MS6_RS09120	COG0616	signal peptide processing
MS6_RS09125	COG0252	asparaginase activity
MS6_RS09130	COG3139	Protein of unknown function (DUF1315)
MS6_RS09140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_RS09145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MS6_RS09150	COG0676	glucose-6-phosphate 1-epimerase activity
MS6_RS09160	COG2226	methyltransferase
MS6_RS09175	COG0835	chemotaxis
MS6_RS09175	COG0784	Response regulator, receiver
MS6_RS09180	COG1940	carbohydrate kinase activity
MS6_RS09190	COG4667	esterase of the alpha-beta hydrolase superfamily
MS6_RS09205	COG0733	neurotransmitter:sodium symporter activity
MS6_RS09210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_RS09210	COG1263	PTS System
MS6_RS09215	COG0084	hydrolase, TatD family'
MS6_RS09225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MS6_RS09230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MS6_RS09235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MS6_RS09240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MS6_RS09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MS6_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
MS6_RS09260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MS6_RS09265	COG0416	fatty acid biosynthetic process
MS6_RS09270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MS6_RS09275	COG1399	metal-binding, possibly nucleic acid-binding protein
MS6_RS09310	COG0424	maF-like protein
MS6_RS09315	COG0564	pseudouridine synthase activity
MS6_RS09330	COG1530	ribonuclease E activity
MS6_RS09335	COG0659	secondary active sulfate transmembrane transporter activity
MS6_RS09345	COG1454	alcohol dehydrogenase
MS6_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
MS6_RS09350	COG2095	MarC family integral membrane protein
MS6_RS09355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MS6_RS09360	COG1757	Na H antiporter
MS6_RS09370	COG3081	Nucleoid-associated protein
MS6_RS09375	COG3082	Protein of unknown function (DUF1414)
MS6_RS09380	COG3083	sulfuric ester hydrolase activity
MS6_RS09395	COG0123	including yeast histone deacetylase and acetoin utilization protein
MS6_RS09400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MS6_RS09405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MS6_RS09425	COG2853	Lipoprotein
MS6_RS09440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MS6_RS09445	COG1138	Cytochrome C-type biogenesis protein
MS6_RS09450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MS6_RS09460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MS6_RS09465	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MS6_RS09470	COG4133	protoheme IX ABC transporter activity
MS6_RS09480	COG0835	chemotaxis
MS6_RS09490	COG1192	Involved in chromosome partitioning
MS6_RS09495	COG2201	protein-glutamate methylesterase activity
MS6_RS09500	COG0643	Histidine kinase
MS6_RS09500	COG2198	Histidine kinase
MS6_RS09500	COG0784	Response regulator, receiver
MS6_RS09505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MS6_RS09535	COG2062	phosphohistidine phosphatase, SixA
MS6_RS09540	COG1025	Belongs to the peptidase M16 family
MS6_RS09550	COG0018	arginyl-trna synthetase
MS6_RS09570	COG1918	ferrous iron import across plasma membrane
MS6_RS09575	COG4977	sequence-specific DNA binding
MS6_RS09580	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MS6_RS09585	COG1121	(ABC) transporter
MS6_RS09590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MS6_RS09600	COG0045	succinate-CoA ligase (ADP-forming) activity
MS6_RS09605	COG0508	dehydrogenase complex catalyzes the overall conversion of
MS6_RS09610	COG0567	Dehydrogenase, E1 component
MS6_RS09620	COG1053	succinate dehydrogenase
MS6_RS09625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MS6_RS09630	COG2009	succinate dehydrogenase
MS6_RS09635	COG0372	Belongs to the citrate synthase family
MS6_RS09640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MS6_RS09650	COG0033	Phosphoglucomutase
MS6_RS09655	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MS6_RS09660	COG0596	Alpha beta hydrolase
MS6_RS09675	COG1346	cytolysis
MS6_RS09685	COG0583	DNA-binding transcription factor activity
MS6_RS09695	COG0735	belongs to the Fur family
MS6_RS09700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MS6_RS09705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MS6_RS09710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MS6_RS09720	COG0431	NADPH-dependent FMN reductase
MS6_RS09730	COG3101	peptidyl-lysine hydroxylation
MS6_RS09735	COG2860	membrane
MS6_RS09740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MS6_RS09750	COG2890	protein-(glutamine-N5) methyltransferase activity
MS6_RS09755	COG2840	Smr protein MutS2
MS6_RS09765	COG1684	flagellar biosynthetic protein fliR
MS6_RS09770	COG1987	bacterial-type flagellum assembly
MS6_RS09795	COG1580	Controls the rotational direction of flagella during chemotaxis
MS6_RS09820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MS6_RS09830	COG1677	Flagellar hook-basal body complex protein FliE
MS6_RS09850	COG1516	flagellar protein fliS
MS6_RS09860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MS6_RS09865	COG1334	flagellar protein FlaG
MS6_RS09870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_RS09875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_RS09880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_RS09885	COG2837	iron assimilation
MS6_RS09905	COG1393	Belongs to the ArsC family
MS6_RS09915	COG1876	peptidase activity
MS6_RS09925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MS6_RS09940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MS6_RS09960	COG4783	chaperone-mediated protein folding
MS6_RS09965	COG1393	Belongs to the ArsC family
MS6_RS09985	COG2233	PERMEase
MS6_RS09990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MS6_RS09995	COG0737	Belongs to the 5'-nucleotidase family
MS6_RS10000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MS6_RS10005	COG2912	Transglutaminase-like superfamily
MS6_RS10015	COG2890	protein-(glutamine-N5) methyltransferase activity
MS6_RS10020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MS6_RS10025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MS6_RS10030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
MS6_RS10035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MS6_RS10040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MS6_RS10045	COG0193	aminoacyl-tRNA hydrolase activity
MS6_RS10050	COG0012	GTP binding
MS6_RS10135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_RS10140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MS6_RS10160	COG3951	Flagellar rod assembly protein muramidase FlgJ
MS6_RS10160	COG1705	Flagellar rod assembly protein muramidase FlgJ
MS6_RS10165	COG1706	bacterial-type flagellum-dependent cell motility
MS6_RS10170	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MS6_RS10180	COG4787	bacterial-type flagellum-dependent cell motility
MS6_RS10185	COG1749	Flagellar hook protein flgE
MS6_RS10200	COG1815	bacterial-type flagellum-dependent cell motility
MS6_RS10205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MS6_RS10210	COG0784	Response regulator, receiver
MS6_RS10210	COG0835	chemotaxis
MS6_RS10245	COG3433	isochorismatase activity
MS6_RS10245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MS6_RS10245	COG2226	methyltransferase
MS6_RS10250	COG2375	cellular response to nickel ion
MS6_RS10255	COG4774	siderophore transport
MS6_RS10255	COG1629	transport
MS6_RS10270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MS6_RS10275	COG2608	mercury ion transmembrane transporter activity
MS6_RS10275	COG2217	Heavy metal translocating P-type atpase
MS6_RS10290	COG3735	TraB family
MS6_RS10305	COG2840	Smr protein MutS2
MS6_RS10310	COG1187	pseudouridine synthase activity
MS6_RS10320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MS6_RS10325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MS6_RS10330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MS6_RS10335	COG0121	glutamine amidotransferase
MS6_RS10340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MS6_RS10345	COG1960	acyl-CoA dehydrogenase activity
MS6_RS10360	COG0328	RNA-DNA hybrid ribonuclease activity
MS6_RS10365	COG2226	methyltransferase
MS6_RS10370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MS6_RS10375	COG1388	LysM domain
MS6_RS10375	COG0741	lytic transglycosylase activity
MS6_RS10380	COG3021	interspecies interaction between organisms
MS6_RS10385	COG0347	Belongs to the P(II) protein family
MS6_RS10390	COG3479	Phenolic acid decarboxylase
MS6_RS10400	COG0037	tRNA processing
MS6_RS10405	COG0825	malonyl-CoA metabolic process
MS6_RS10410	COG0587	DNA-directed DNA polymerase activity
MS6_RS10415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MS6_RS10420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_RS10425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_RS10430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MS6_RS10435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MS6_RS10440	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
MS6_RS10450	COG0750	zinc metalloprotease
MS6_RS10455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MS6_RS10460	COG0575	Belongs to the CDS family
MS6_RS10465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MS6_RS10470	COG0233	cytoplasmic translational termination
MS6_RS10475	COG0528	UMP kinase activity
MS6_RS10480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MS6_RS10485	COG0052	Belongs to the universal ribosomal protein uS2 family
MS6_RS10490	COG0024	Methionine aminopeptidase
MS6_RS10495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MS6_RS10505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MS6_RS10510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MS6_RS10515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MS6_RS10520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MS6_RS10535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MS6_RS10535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MS6_RS10540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MS6_RS10545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MS6_RS10550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MS6_RS10560	COG1073	alpha beta
MS6_RS10565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MS6_RS10570	COG2252	PERMEase
MS6_RS10575	COG2195	Cleaves the N-terminal amino acid of tripeptides
MS6_RS10580	COG0189	ligase activity
MS6_RS10580	COG4067	protein conserved in archaea
MS6_RS10585	COG0189	ligase activity
MS6_RS10595	COG0733	neurotransmitter:sodium symporter activity
MS6_RS10600	COG3706	GGDEF domain
MS6_RS10620	COG1477	protein flavinylation
MS6_RS10625	COG2871	sodium ion transport
MS6_RS10630	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_RS10635	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_RS10640	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_RS10645	COG1805	sodium ion transport
MS6_RS10650	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MS6_RS10655	COG0271	Belongs to the BolA IbaG family
MS6_RS10660	COG2813	Specifically methylates the guanine in position
MS6_RS10670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MS6_RS10675	COG2211	Major facilitator Superfamily
MS6_RS10685	COG1595	DNA-templated transcription, initiation
MS6_RS10695	COG3248	Nucleoside-binding outer membrane protein
MS6_RS10700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MS6_RS10705	COG0693	protein deglycase activity
MS6_RS10710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MS6_RS10715	COG2166	iron-sulfur cluster assembly
MS6_RS10720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MS6_RS10725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MS6_RS10735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MS6_RS10735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MS6_RS10750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MS6_RS10755	COG1074	ATP-dependent DNA helicase activity
MS6_RS10760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MS6_RS10775	COG3141	response to X-ray
MS6_RS10780	COG2171	N-acyltransferase activity
MS6_RS10790	COG0456	acetyltransferase
MS6_RS10795	COG0569	domain protein
MS6_RS10795	COG0189	ligase activity
MS6_RS10810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MS6_RS10815	COG1609	Transcriptional regulator
MS6_RS10820	COG3250	beta-galactosidase activity
MS6_RS10835	COG1022	Amp-dependent synthetase and ligase
MS6_RS10840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MS6_RS10845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MS6_RS10855	COG0560	Phosphoserine phosphatase
MS6_RS10865	COG0813	purine-nucleoside phosphorylase activity
MS6_RS10870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MS6_RS10875	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MS6_RS10880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MS6_RS10890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MS6_RS10895	COG0084	hydrolase, TatD family'
MS6_RS10900	COG3022	response to hydroperoxide
MS6_RS10905	COG1115	amino acid carrier protein
MS6_RS10920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MS6_RS10925	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MS6_RS10930	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
MS6_RS10935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MS6_RS10955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MS6_RS10965	COG0745	RESPONSE REGULATOR receiver
MS6_RS10970	COG5002	protein histidine kinase activity
MS6_RS10970	COG0784	Response regulator, receiver
MS6_RS10970	COG2198	Histidine kinase
MS6_RS10975	COG2203	Gaf domain
MS6_RS10975	COG3706	GGDEF domain
MS6_RS10975	COG4251	negative regulation of phosphorylation
MS6_RS10975	COG5001	Diguanylate cyclase
MS6_RS10980	COG1242	4 iron, 4 sulfur cluster binding
MS6_RS10985	COG0070	glutamate synthase
MS6_RS10985	COG0067	glutamate synthase
MS6_RS10985	COG0069	glutamate synthase activity
MS6_RS10995	COG0067	glutamate synthase
MS6_RS10995	COG0070	glutamate synthase
MS6_RS10995	COG0069	glutamate synthase activity
MS6_RS11000	COG0493	'glutamate synthase
MS6_RS11010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MS6_RS11020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MS6_RS11025	COG2860	membrane
MS6_RS11030	COG0583	DNA-binding transcription factor activity
MS6_RS11035	COG0730	response to heat
MS6_RS11045	COG4172	Belongs to the ABC transporter superfamily
MS6_RS11065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MS6_RS11070	COG0505	Belongs to the CarA family
MS6_RS11080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MS6_RS11085	COG0494	nUDIX hydrolase
MS6_RS11095	COG0653	protein targeting
MS6_RS11105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MS6_RS11110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MS6_RS11115	COG0849	cell division
MS6_RS11120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MS6_RS11125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MS6_RS11130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MS6_RS11135	COG0772	Belongs to the SEDS family
MS6_RS11140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MS6_RS11150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MS6_RS11155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MS6_RS11160	COG0768	penicillin binding
MS6_RS11165	COG3116	cell division
MS6_RS11175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_RS11180	COG0508	dehydrogenase complex catalyzes the overall conversion of
MS6_RS11185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MS6_RS11190	COG2186	Transcriptional regulator
MS6_RS11195	COG0737	Belongs to the 5'-nucleotidase family
MS6_RS11200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MS6_RS11205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MS6_RS11210	COG4974	Belongs to the 'phage' integrase family
MS6_RS11215	COG0716	FMN binding
MS6_RS11235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_RS11240	COG1459	type II secretion system
MS6_RS11250	COG0237	dephospho-CoA kinase activity
MS6_RS11255	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MS6_RS11265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MS6_RS11270	COG0187	DNA topoisomerase II activity
MS6_RS11275	COG3150	esterase
MS6_RS11285	COG3151	Protein conserved in bacteria
MS6_RS11290	COG0494	nUDIX hydrolase
MS6_RS11295	COG1538	Outer membrane efflux protein
MS6_RS11305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MS6_RS11310	COG0840	transmembrane signaling receptor activity
MS6_RS11315	COG3025	triphosphatase activity
MS6_RS11320	COG1392	Phosphate transport regulator
MS6_RS11325	COG0306	phosphate transporter
MS6_RS11330	COG4991	sh3 domain protein
MS6_RS11340	COG3409	Peptidoglycan-binding domain 1 protein
MS6_RS11340	COG3267	Type II secretory pathway component ExeA
MS6_RS11350	COG0148	phosphopyruvate hydratase activity
MS6_RS11355	COG0504	CTP synthase activity
MS6_RS11360	COG3956	TIGRFAM MazG family protein
MS6_RS11365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MS6_RS11400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MS6_RS11405	COG1381	Involved in DNA repair and RecF pathway recombination
MS6_RS11410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MS6_RS11425	COG0481	GTPase activity
MS6_RS11430	COG3086	response to oxidative stress
MS6_RS11445	COG1595	DNA-templated transcription, initiation
MS6_RS11455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MS6_RS11465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MS6_RS11480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_RS11485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MS6_RS11490	COG3079	Belongs to the UPF0149 family
MS6_RS11495	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MS6_RS11500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MS6_RS11505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MS6_RS11510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MS6_RS11515	COG0440	acetolactate synthase activity
MS6_RS11520	COG0028	Belongs to the TPP enzyme family
MS6_RS11525	COG1022	Amp-dependent synthetase and ligase
MS6_RS11530	COG0583	DNA-binding transcription factor activity
MS6_RS11555	COG0473	3-isopropylmalate dehydrogenase activity
MS6_RS11560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MS6_RS11565	COG0066	3-isopropylmalate dehydratase activity
MS6_RS11610	COG3437	response regulator, receiver
MS6_RS11625	COG0795	lipopolysaccharide-transporting ATPase activity
MS6_RS11630	COG0795	lipopolysaccharide-transporting ATPase activity
MS6_RS11635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MS6_RS11640	COG2927	DNA polymerase III (CHI subunit)
MS6_RS11645	COG0525	valine-tRNA ligase activity
MS6_RS11650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MS6_RS11655	COG0564	pseudouridine synthase activity
MS6_RS11670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MS6_RS11685	COG0540	Belongs to the ATCase OTCase family
MS6_RS11695	COG0251	oxidation-reduction process
MS6_RS11705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MS6_RS11710	COG5007	Belongs to the BolA IbaG family
MS6_RS11720	COG2854	intermembrane phospholipid transfer
MS6_RS11725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MS6_RS11730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MS6_RS11735	COG1127	ABC transporter
MS6_RS11750	COG0517	IMP dehydrogenase activity
MS6_RS11750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MS6_RS11765	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MS6_RS11770	COG1137	ATPase activity
MS6_RS11780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MS6_RS11785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_RS11790	COG1660	Displays ATPase and GTPase activities
MS6_RS11795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MS6_RS11800	COG2239	Acts as a magnesium transporter
MS6_RS11805	COG0312	modulator of DNA gyrase
MS6_RS11810	COG3028	Belongs to the UPF0307 family
MS6_RS11815	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MS6_RS11820	COG1178	ABC-type Fe3 transport system permease component
MS6_RS11830	COG0163	prenyltransferase activity
MS6_RS11835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MS6_RS11850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MS6_RS11855	COG2105	PFAM AIG2 family protein
MS6_RS11865	COG0729	surface antigen
MS6_RS11870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MS6_RS11875	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
MS6_RS11890	COG1136	(ABC) transporter
MS6_RS11910	COG0529	Catalyzes the synthesis of activated sulfate
MS6_RS11925	COG1648	precorrin-2 dehydrogenase activity
MS6_RS11925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MS6_RS11930	COG0737	Belongs to the 5'-nucleotidase family
MS6_RS11940	COG0513	Belongs to the DEAD box helicase family
MS6_RS11945	COG2153	protein acetylation
MS6_RS11950	COG0697	spore germination
MS6_RS11955	COG3266	domain, Protein
MS6_RS11955	COG3061	Opacity-associated protein A
MS6_RS11960	COG0545	Peptidyl-prolyl cis-trans isomerase
MS6_RS11970	COG0203	ribosomal protein L17
MS6_RS11975	COG0202	RNA polymerase activity
MS6_RS11980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MS6_RS11985	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MS6_RS11990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MS6_RS11995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MS6_RS12000	COG0201	protein transport
MS6_RS12010	COG1841	ribosomal large subunit assembly
MS6_RS12015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MS6_RS12020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MS6_RS12030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MS6_RS12035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MS6_RS12040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MS6_RS12045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MS6_RS12050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MS6_RS12055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MS6_RS12060	COG0255	Belongs to the universal ribosomal protein uL29 family
MS6_RS12065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MS6_RS12070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MS6_RS12075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MS6_RS12080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MS6_RS12085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MS6_RS12090	COG0089	rRNA binding
MS6_RS12095	COG0088	Forms part of the polypeptide exit tunnel
MS6_RS12100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MS6_RS12105	COG0051	transcription antitermination factor activity, RNA binding
MS6_RS12110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MS6_RS12115	COG0557	exoribonuclease II activity
MS6_RS12120	COG3083	sulfuric ester hydrolase activity
MS6_RS12125	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MS6_RS12140	COG1047	Peptidyl-prolyl cis-trans
MS6_RS12155	COG2249	NAD(P)H dehydrogenase (quinone) activity
MS6_RS12160	COG0488	(ABC) transporter
MS6_RS12170	COG0429	hydrolase of the alpha beta-hydrolase fold
MS6_RS12180	COG3954	Phosphoribulokinase
MS6_RS12205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MS6_RS12215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MS6_RS12230	COG0180	Tryptophanyl-tRNA synthetase
MS6_RS12235	COG0546	phosphoglycolate phosphatase activity
MS6_RS12240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MS6_RS12245	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MS6_RS12255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MS6_RS12260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MS6_RS12290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MS6_RS12300	COG0678	peroxiredoxin activity
MS6_RS12300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MS6_RS12305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_RS12315	COG0165	Argininosuccinate lyase
MS6_RS12320	COG0137	argininosuccinate synthase activity
MS6_RS12325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MS6_RS12330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MS6_RS12335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MS6_RS12340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MS6_RS12350	COG1045	serine acetyltransferase
MS6_RS12355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MS6_RS12360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MS6_RS12365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MS6_RS12370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MS6_RS12375	COG1053	succinate dehydrogenase
MS6_RS12380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MS6_RS12385	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
MS6_RS12395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MS6_RS12400	COG1509	lysine 2,3-aminomutase activity
MS6_RS12410	COG0459	protein refolding
MS6_RS12415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MS6_RS12440	COG0149	triose-phosphate isomerase activity
MS6_RS12445	COG0534	Mate efflux family protein
MS6_RS12450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MS6_RS12455	COG1575	Belongs to the MenA family. Type 1 subfamily
MS6_RS12460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MS6_RS12465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MS6_RS12470	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MS6_RS12475	COG1609	Transcriptional regulator
MS6_RS12480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MS6_RS12485	COG0254	rRNA binding
MS6_RS12490	COG0281	malic enzyme
MS6_RS12495	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
MS6_RS12500	COG0626	cystathionine gamma-synthase activity
MS6_RS12505	COG0460	homoserine dehydrogenase
MS6_RS12505	COG0527	aspartate kinase activity
MS6_RS12510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MS6_RS12515	COG3074	FtsZ-dependent cytokinesis
MS6_RS12520	COG1494	fructose-1,6-bisphosphatase
MS6_RS12525	COG0205	6-phosphofructokinase activity
MS6_RS12530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MS6_RS12540	COG0745	RESPONSE REGULATOR receiver
MS6_RS12545	COG2205	protein histidine kinase activity
MS6_RS12555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MS6_RS12560	COG3030	protein affecting phage T7 exclusion by the F plasmid
MS6_RS12565	COG3706	GGDEF domain
MS6_RS12570	COG1027	Aspartate ammonia-lyase
MS6_RS12575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MS6_RS12585	COG4232	protein-disulfide reductase activity
MS6_RS12605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MS6_RS12610	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MS6_RS12615	COG0194	GDP metabolic process
MS6_RS12620	COG1758	RNA polymerase activity
MS6_RS12625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MS6_RS12630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MS6_RS12635	COG2233	PERMEase
MS6_RS12650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MS6_RS12655	COG2183	response to ionizing radiation
MS6_RS12665	COG0596	Alpha beta hydrolase
MS6_RS12670	COG1040	competence protein
MS6_RS12680	COG0494	nUDIX hydrolase
MS6_RS12685	COG1218	3'(2'),5'-bisphosphate nucleotidase
MS6_RS12695	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MS6_RS12700	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MS6_RS12705	COG3156	type II secretion system protein K
MS6_RS12710	COG4795	General secretion pathway protein
MS6_RS12715	COG2165	general secretion pathway protein
MS6_RS12720	COG2165	general secretion pathway protein
MS6_RS12725	COG2165	general secretion pathway protein
MS6_RS12730	COG1459	type II secretion system
MS6_RS12735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_RS12745	COG3031	protein transport across the cell outer membrane
MS6_RS12750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MS6_RS12755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MS6_RS12760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MS6_RS12770	COG0456	acetyltransferase
MS6_RS12775	COG1490	D-aminoacyl-tRNA deacylase activity
MS6_RS12780	COG1295	ribonuclease BN
MS6_RS12790	COG1217	gtp-binding protein TYPA
MS6_RS12800	COG0174	glutamine synthetase
MS6_RS12810	COG3852	Histidine kinase
MS6_RS12820	COG5001	Diguanylate cyclase
MS6_RS12820	COG3300	MHYT domain
MS6_RS12825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MS6_RS12860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MS6_RS12865	COG1404	Belongs to the peptidase S8 family
MS6_RS12870	COG4206	TonB-dependent receptor
MS6_RS12875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MS6_RS12890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MS6_RS12895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MS6_RS12900	COG2177	Part of the ABC transporter FtsEX involved in
MS6_RS12905	COG2884	Cell division ATP-binding protein ftsE
MS6_RS12910	COG0552	protein localization to endoplasmic reticulum
MS6_RS12915	COG0742	ribosomal rna small subunit methyltransferase
MS6_RS12950	COG0783	Belongs to the Dps family
MS6_RS12955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MS6_RS12960	COG1280	lysine exporter protein (LysE YggA)
MS6_RS12965	COG2267	carboxylic ester hydrolase activity
MS6_RS12970	COG0561	phosphatase activity
MS6_RS12990	COG2199	diguanylate cyclase activity
MS6_RS12990	COG3287	FIST C domain
MS6_RS12990	COG2200	EAL domain
MS6_RS12995	COG1011	Hydrolase
MS6_RS13000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MS6_RS13010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MS6_RS13015	COG0019	diaminopimelate decarboxylase activity
MS6_RS13025	COG1965	Belongs to the frataxin family
MS6_RS13040	COG0181	hydroxymethylbilane synthase activity
MS6_RS13045	COG1587	Uroporphyrinogen-III synthase
MS6_RS13050	COG2959	enzyme of heme biosynthesis
MS6_RS13055	COG3071	HemY protein
MS6_RS13070	COG3078	GTPase activator activity
MS6_RS13090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MS6_RS13090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MS6_RS13105	COG0084	hydrolase, TatD family'
MS6_RS13115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MS6_RS13125	COG0840	transmembrane signaling receptor activity
MS6_RS13130	COG1580	Controls the rotational direction of flagella during chemotaxis
MS6_RS13140	COG3161	chorismate lyase activity
MS6_RS13145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MS6_RS13155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MS6_RS13165	COG0534	Mate efflux family protein
MS6_RS13170	COG1858	cytochrome C peroxidase
MS6_RS13175	COG0805	protein transport
MS6_RS13180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MS6_RS13185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MS6_RS13200	COG2226	methyltransferase
MS6_RS13205	COG1322	Protein conserved in bacteria
MS6_RS13215	COG2081	HI0933 family
MS6_RS13225	COG1528	Iron-storage protein
MS6_RS13235	COG0589	response to stress
MS6_RS13255	COG5002	protein histidine kinase activity
MS6_RS13255	COG5001	Diguanylate cyclase
MS6_RS13260	COG1522	sequence-specific DNA binding
MS6_RS13280	COG0006	proline dipeptidase activity
MS6_RS13280	COG0006	proline dipeptidase activity
MS6_RS13285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MS6_RS13290	COG2022	thiamine diphosphate biosynthetic process
MS6_RS13295	COG2104	thiamine diphosphate biosynthetic process
MS6_RS13300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MS6_RS13310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MS6_RS13315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MS6_RS13355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MS6_RS13365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MS6_RS13370	COG0408	coproporphyrinogen oxidase activity
MS6_RS13375	COG0009	L-threonylcarbamoyladenylate synthase
MS6_RS13380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MS6_RS13385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MS6_RS13390	COG0551	DNA topoisomerase type I activity
MS6_RS13395	COG2922	Belongs to the Smg family
MS6_RS13400	COG0758	DNA mediated transformation
MS6_RS13405	COG1652	LysM domain
MS6_RS13410	COG0242	peptide deformylase activity
MS6_RS13415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MS6_RS13420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MS6_RS13420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MS6_RS13425	COG0569	domain protein
MS6_RS13430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MS6_RS13440	COG1272	protein, Hemolysin III
MS6_RS13445	COG4326	sporulation control protein
MS6_RS13455	COG3084	Protein conserved in bacteria
MS6_RS13465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MS6_RS13470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MS6_RS13475	COG0204	Acyl-transferase
MS6_RS13480	COG0606	chelatase, subunit chli
MS6_RS13495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MS6_RS13500	COG0129	dihydroxy-acid dehydratase activity
MS6_RS13510	COG0604	alcohol dehydrogenase
MS6_RS13520	COG0425	Belongs to the sulfur carrier protein TusA family
MS6_RS13530	COG2119	membrane
MS6_RS13535	COG0752	glycyl-tRNA synthetase alpha subunit
MS6_RS13540	COG0751	glycine-tRNA ligase activity
MS6_RS13545	COG3977	Valine--pyruvate aminotransferase
MS6_RS13550	COG0071	Belongs to the small heat shock protein (HSP20) family
MS6_RS13565	COG0187	DNA topoisomerase II activity
MS6_RS13570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MS6_RS13575	COG0592	DNA-directed DNA polymerase activity
MS6_RS13580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MS6_RS13715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MS6_RS13730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_RS13870	COG0210	DNA helicase
MS6_RS13960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MS6_RS13960	COG1263	PTS System
MS6_RS14340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MS6_RS14415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MS6_RS14505	COG0085	RNA polymerase activity
MS6_RS14525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MS6_RS14600	COG0860	N-Acetylmuramoyl-L-alanine amidase
MS6_RS14600	COG1388	LysM domain
MS6_RS14610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MS6_RS14760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MS6_RS14920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MS6_RS14930	COG1459	type II secretion system
MS6_RS15000	COG1077	Cell shape determining protein MreB Mrl
MS6_RS15020	COG1530	ribonuclease E activity
MS6_RS15065	COG0312	modulator of DNA gyrase
MS6_RS15180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MS6_RS15205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MS6_RS15340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MS6_RS15545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MS6_RS15680	COG0585	pseudouridine synthase activity
MS6_RS15760	COG4208	sulfate ABC transporter
MS6_RS15770	COG1546	Belongs to the CinA family
MS6_RS15800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MS6_RS15915	COG2918	glutathione biosynthetic process
MS6_RS15935	COG4536	flavin adenine dinucleotide binding
MS6_RS15950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MS6_RS16325	COG0195	Participates in both transcription termination and antitermination
MS6_RS16380	COG0826	peptidase U32
MS6_RS16435	COG1114	Component of the transport system for branched-chain amino acids
MS6_RS16575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MS6_RS16590	COG1472	Belongs to the glycosyl hydrolase 3 family
MS6_RS16685	COG0542	response to heat
MS6_RS16920	COG0516	GMP reductase activity
MS6_RS16920	COG0517	IMP dehydrogenase activity
MS6_RS17050	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MS6_RS17330	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MS6_RS17545	COG0142	geranyltranstransferase activity
MS6_RS17620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MS6_RS18025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MS6_RS18120	COG4660	Part of a membrane complex involved in electron transport
MS6_RS18140	COG4656	Part of a membrane complex involved in electron transport
MS6_RS18335	COG1946	Acyl-CoA thioesterase
MS6_RS18440	COG2204	response regulator
MS6_RS18495	COG0857	belongs to the CobB CobQ family
MS6_RS18495	COG0280	phosphate acetyltransferase
MS6_RS18510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MS6_RS18745	COG4191	Histidine kinase