locus-tag	class	description
NW313_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NW313_RS00010	COG0592	DNA-directed DNA polymerase activity
NW313_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NW313_RS00020	COG0187	DNA topoisomerase II activity
NW313_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
NW313_RS00035	COG3977	Valine--pyruvate aminotransferase
NW313_RS00040	COG0751	glycine-tRNA ligase activity
NW313_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
NW313_RS00050	COG2119	membrane
NW313_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
NW313_RS00070	COG0604	alcohol dehydrogenase
NW313_RS00080	COG0129	dihydroxy-acid dehydratase activity
NW313_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NW313_RS00100	COG0606	chelatase, subunit chli
NW313_RS00105	COG0204	Acyl-transferase
NW313_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NW313_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NW313_RS00125	COG3084	Protein conserved in bacteria
NW313_RS00130	COG4326	sporulation control protein
NW313_RS00135	COG1272	protein, Hemolysin III
NW313_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NW313_RS00150	COG0569	domain protein
NW313_RS00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NW313_RS00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NW313_RS00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NW313_RS00165	COG0242	peptide deformylase activity
NW313_RS00170	COG1652	LysM domain
NW313_RS00175	COG0758	DNA mediated transformation
NW313_RS00180	COG2922	Belongs to the Smg family
NW313_RS00185	COG0551	DNA topoisomerase type I activity
NW313_RS00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NW313_RS00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NW313_RS00200	COG0009	L-threonylcarbamoyladenylate synthase
NW313_RS00205	COG0408	coproporphyrinogen oxidase activity
NW313_RS00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NW313_RS00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NW313_RS00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NW313_RS00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NW313_RS00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NW313_RS00280	COG2104	thiamine diphosphate biosynthetic process
NW313_RS00285	COG2022	thiamine diphosphate biosynthetic process
NW313_RS00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NW313_RS00295	COG0006	proline dipeptidase activity
NW313_RS00295	COG0006	proline dipeptidase activity
NW313_RS00315	COG1522	sequence-specific DNA binding
NW313_RS00320	COG5002	protein histidine kinase activity
NW313_RS00320	COG5001	Diguanylate cyclase
NW313_RS00340	COG0589	response to stress
NW313_RS00345	COG1528	Iron-storage protein
NW313_RS00355	COG2081	HI0933 family
NW313_RS00365	COG1322	Protein conserved in bacteria
NW313_RS00370	COG2226	methyltransferase
NW313_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NW313_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NW313_RS00395	COG0805	protein transport
NW313_RS00400	COG1858	cytochrome C peroxidase
NW313_RS00405	COG0534	Mate efflux family protein
NW313_RS00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NW313_RS00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NW313_RS00430	COG3161	chorismate lyase activity
NW313_RS00435	COG1580	Controls the rotational direction of flagella during chemotaxis
NW313_RS00440	COG0840	transmembrane signaling receptor activity
NW313_RS00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NW313_RS00455	COG0084	hydrolase, TatD family'
NW313_RS00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NW313_RS00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NW313_RS00490	COG3078	GTPase activator activity
NW313_RS00505	COG3071	HemY protein
NW313_RS00510	COG2959	enzyme of heme biosynthesis
NW313_RS00515	COG1587	Uroporphyrinogen-III synthase
NW313_RS00520	COG0181	hydroxymethylbilane synthase activity
NW313_RS00530	COG1965	Belongs to the frataxin family
NW313_RS00540	COG0019	diaminopimelate decarboxylase activity
NW313_RS00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NW313_RS00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NW313_RS00560	COG1011	Hydrolase
NW313_RS00565	COG3287	FIST C domain
NW313_RS00565	COG2200	EAL domain
NW313_RS00565	COG2199	diguanylate cyclase activity
NW313_RS00580	COG0561	phosphatase activity
NW313_RS00585	COG2267	carboxylic ester hydrolase activity
NW313_RS00590	COG1280	lysine exporter protein (LysE YggA)
NW313_RS00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NW313_RS00600	COG0783	Belongs to the Dps family
NW313_RS00630	COG0742	ribosomal rna small subunit methyltransferase
NW313_RS00635	COG0552	protein localization to endoplasmic reticulum
NW313_RS00640	COG2884	Cell division ATP-binding protein ftsE
NW313_RS00645	COG2177	Part of the ABC transporter FtsEX involved in
NW313_RS00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NW313_RS00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NW313_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NW313_RS00675	COG4206	TonB-dependent receptor
NW313_RS00680	COG1404	Belongs to the peptidase S8 family
NW313_RS00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NW313_RS00720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NW313_RS00725	COG3300	MHYT domain
NW313_RS00725	COG5001	Diguanylate cyclase
NW313_RS00735	COG3852	Histidine kinase
NW313_RS00745	COG0174	glutamine synthetase
NW313_RS00755	COG1217	gtp-binding protein TYPA
NW313_RS00765	COG1295	ribonuclease BN
NW313_RS00770	COG1490	D-aminoacyl-tRNA deacylase activity
NW313_RS00775	COG0456	acetyltransferase
NW313_RS00785	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NW313_RS00790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NW313_RS00795	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NW313_RS00800	COG3031	protein transport across the cell outer membrane
NW313_RS00810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NW313_RS00815	COG1459	type II secretion system
NW313_RS00820	COG2165	general secretion pathway protein
NW313_RS00825	COG2165	general secretion pathway protein
NW313_RS00830	COG2165	general secretion pathway protein
NW313_RS00835	COG4795	General secretion pathway protein
NW313_RS00840	COG3156	type II secretion system protein K
NW313_RS00845	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NW313_RS00850	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NW313_RS00860	COG1218	3'(2'),5'-bisphosphate nucleotidase
NW313_RS00865	COG0494	nUDIX hydrolase
NW313_RS00875	COG1040	competence protein
NW313_RS00885	COG0596	Alpha beta hydrolase
NW313_RS00895	COG2183	response to ionizing radiation
NW313_RS00900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NW313_RS00915	COG2233	PERMEase
NW313_RS00920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NW313_RS00925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NW313_RS00930	COG1758	RNA polymerase activity
NW313_RS00935	COG0194	GDP metabolic process
NW313_RS00940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NW313_RS00945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NW313_RS00965	COG4232	protein-disulfide reductase activity
NW313_RS00975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NW313_RS00980	COG1027	Aspartate ammonia-lyase
NW313_RS00985	COG3706	GGDEF domain
NW313_RS00990	COG3030	protein affecting phage T7 exclusion by the F plasmid
NW313_RS00995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NW313_RS01005	COG2205	protein histidine kinase activity
NW313_RS01010	COG0745	RESPONSE REGULATOR receiver
NW313_RS01020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NW313_RS01025	COG0205	6-phosphofructokinase activity
NW313_RS01030	COG1494	fructose-1,6-bisphosphatase
NW313_RS01035	COG3074	FtsZ-dependent cytokinesis
NW313_RS01040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NW313_RS01045	COG0527	aspartate kinase activity
NW313_RS01045	COG0460	homoserine dehydrogenase
NW313_RS01050	COG0626	cystathionine gamma-synthase activity
NW313_RS01055	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
NW313_RS01060	COG0281	malic enzyme
NW313_RS01065	COG0254	rRNA binding
NW313_RS01070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NW313_RS01075	COG1609	Transcriptional regulator
NW313_RS01080	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NW313_RS01085	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NW313_RS01090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NW313_RS01095	COG1575	Belongs to the MenA family. Type 1 subfamily
NW313_RS01100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NW313_RS01105	COG0534	Mate efflux family protein
NW313_RS01110	COG0149	triose-phosphate isomerase activity
NW313_RS01135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NW313_RS01140	COG0459	protein refolding
NW313_RS01150	COG1509	lysine 2,3-aminomutase activity
NW313_RS01155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NW313_RS01165	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NW313_RS01170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NW313_RS01175	COG1053	succinate dehydrogenase
NW313_RS01180	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NW313_RS01185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NW313_RS01190	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NW313_RS01195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NW313_RS01200	COG1045	serine acetyltransferase
NW313_RS01210	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NW313_RS01215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NW313_RS01220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NW313_RS01225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NW313_RS01230	COG0137	argininosuccinate synthase activity
NW313_RS01235	COG0165	Argininosuccinate lyase
NW313_RS01245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NW313_RS01250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NW313_RS01250	COG0678	peroxiredoxin activity
NW313_RS01260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NW313_RS01290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NW313_RS01295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NW313_RS01305	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NW313_RS01310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NW313_RS01315	COG0546	phosphoglycolate phosphatase activity
NW313_RS01320	COG0180	Tryptophanyl-tRNA synthetase
NW313_RS01335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NW313_RS01345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NW313_RS01355	COG1012	belongs to the aldehyde dehydrogenase family
NW313_RS01370	COG3954	Phosphoribulokinase
NW313_RS01380	COG0429	hydrolase of the alpha beta-hydrolase fold
NW313_RS01390	COG0488	(ABC) transporter
NW313_RS01395	COG2249	NAD(P)H dehydrogenase (quinone) activity
NW313_RS01410	COG1047	Peptidyl-prolyl cis-trans
NW313_RS01425	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NW313_RS01430	COG3083	sulfuric ester hydrolase activity
NW313_RS01435	COG0557	exoribonuclease II activity
NW313_RS01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NW313_RS01445	COG0051	transcription antitermination factor activity, RNA binding
NW313_RS01450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NW313_RS01455	COG0088	Forms part of the polypeptide exit tunnel
NW313_RS01460	COG0089	rRNA binding
NW313_RS01465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NW313_RS01470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NW313_RS01475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NW313_RS01480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NW313_RS01485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NW313_RS01490	COG0255	Belongs to the universal ribosomal protein uL29 family
NW313_RS01495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NW313_RS01500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NW313_RS01505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NW313_RS01510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NW313_RS01515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NW313_RS01520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NW313_RS01530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NW313_RS01535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NW313_RS01540	COG1841	ribosomal large subunit assembly
NW313_RS01550	COG0201	protein transport
NW313_RS01555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NW313_RS01560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NW313_RS01565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NW313_RS01570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NW313_RS01575	COG0202	RNA polymerase activity
NW313_RS01580	COG0203	ribosomal protein L17
NW313_RS01590	COG0545	Peptidyl-prolyl cis-trans isomerase
NW313_RS01595	COG3266	domain, Protein
NW313_RS01595	COG3061	Opacity-associated protein A
NW313_RS01600	COG0697	spore germination
NW313_RS01605	COG2153	protein acetylation
NW313_RS01610	COG0513	Belongs to the DEAD box helicase family
NW313_RS01625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NW313_RS01625	COG1648	precorrin-2 dehydrogenase activity
NW313_RS01640	COG0529	Catalyzes the synthesis of activated sulfate
NW313_RS01660	COG1136	(ABC) transporter
NW313_RS01675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NW313_RS01680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NW313_RS01685	COG0729	surface antigen
NW313_RS01695	COG2105	PFAM AIG2 family protein
NW313_RS01700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NW313_RS01710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NW313_RS01715	COG0163	prenyltransferase activity
NW313_RS01725	COG1178	ABC-type Fe3 transport system permease component
NW313_RS01730	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NW313_RS01735	COG3028	Belongs to the UPF0307 family
NW313_RS01740	COG0312	modulator of DNA gyrase
NW313_RS01745	COG2239	Acts as a magnesium transporter
NW313_RS01750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW313_RS01755	COG1660	Displays ATPase and GTPase activities
NW313_RS01760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW313_RS01765	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NW313_RS01775	COG1137	ATPase activity
NW313_RS01780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NW313_RS01795	COG0517	IMP dehydrogenase activity
NW313_RS01795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NW313_RS01805	COG1127	ABC transporter
NW313_RS01810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NW313_RS01815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NW313_RS01820	COG2854	intermembrane phospholipid transfer
NW313_RS01830	COG5007	Belongs to the BolA IbaG family
NW313_RS01835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NW313_RS01845	COG0251	oxidation-reduction process
NW313_RS01855	COG0540	Belongs to the ATCase OTCase family
NW313_RS01865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NW313_RS01875	COG0564	pseudouridine synthase activity
NW313_RS01880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NW313_RS01885	COG0525	valine-tRNA ligase activity
NW313_RS01890	COG2927	DNA polymerase III (CHI subunit)
NW313_RS01895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NW313_RS01900	COG0795	lipopolysaccharide-transporting ATPase activity
NW313_RS01905	COG0795	lipopolysaccharide-transporting ATPase activity
NW313_RS01920	COG3437	response regulator, receiver
NW313_RS01965	COG0066	3-isopropylmalate dehydratase activity
NW313_RS01970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NW313_RS01975	COG0473	3-isopropylmalate dehydrogenase activity
NW313_RS02000	COG0583	DNA-binding transcription factor activity
NW313_RS02005	COG1022	Amp-dependent synthetase and ligase
NW313_RS02010	COG0028	Belongs to the TPP enzyme family
NW313_RS02015	COG0440	acetolactate synthase activity
NW313_RS02020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NW313_RS02025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NW313_RS02030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NW313_RS02040	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NW313_RS02045	COG3079	Belongs to the UPF0149 family
NW313_RS02050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NW313_RS02055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NW313_RS02070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NW313_RS02080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NW313_RS02085	COG1595	DNA-templated transcription, initiation
NW313_RS02100	COG3086	response to oxidative stress
NW313_RS02105	COG0481	GTPase activity
NW313_RS02120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NW313_RS02125	COG1381	Involved in DNA repair and RecF pathway recombination
NW313_RS02130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NW313_RS02150	COG5001	Diguanylate cyclase
NW313_RS02165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NW313_RS02170	COG3956	TIGRFAM MazG family protein
NW313_RS02175	COG0504	CTP synthase activity
NW313_RS02180	COG0148	phosphopyruvate hydratase activity
NW313_RS02190	COG3267	Type II secretory pathway component ExeA
NW313_RS02190	COG3409	Peptidoglycan-binding domain 1 protein
NW313_RS02200	COG4991	sh3 domain protein
NW313_RS02205	COG0306	phosphate transporter
NW313_RS02210	COG1392	Phosphate transport regulator
NW313_RS02215	COG3025	triphosphatase activity
NW313_RS02220	COG0840	transmembrane signaling receptor activity
NW313_RS02225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NW313_RS02235	COG1538	Outer membrane efflux protein
NW313_RS02240	COG0494	nUDIX hydrolase
NW313_RS02245	COG3151	Protein conserved in bacteria
NW313_RS02255	COG3150	esterase
NW313_RS02260	COG0187	DNA topoisomerase II activity
NW313_RS02265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NW313_RS02275	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
NW313_RS02280	COG0237	dephospho-CoA kinase activity
NW313_RS02290	COG1459	type II secretion system
NW313_RS02295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NW313_RS02315	COG0716	FMN binding
NW313_RS02320	COG4974	Belongs to the 'phage' integrase family
NW313_RS02325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NW313_RS02330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NW313_RS02335	COG0737	Belongs to the 5'-nucleotidase family
NW313_RS02340	COG2186	Transcriptional regulator
NW313_RS02345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NW313_RS02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
NW313_RS02355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NW313_RS02370	COG3116	cell division
NW313_RS02375	COG0768	penicillin binding
NW313_RS02380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NW313_RS02385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NW313_RS02395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NW313_RS02400	COG0772	Belongs to the SEDS family
NW313_RS02410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NW313_RS02415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NW313_RS02420	COG0849	cell division
NW313_RS02425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NW313_RS02430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NW313_RS02440	COG0653	protein targeting
NW313_RS02445	COG0494	nUDIX hydrolase
NW313_RS02450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NW313_RS02460	COG0505	Belongs to the CarA family
NW313_RS02465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NW313_RS02480	COG4172	Belongs to the ABC transporter superfamily
NW313_RS02490	COG0730	response to heat
NW313_RS02495	COG0583	DNA-binding transcription factor activity
NW313_RS02500	COG2860	membrane
NW313_RS02505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NW313_RS02515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NW313_RS02525	COG0493	'glutamate synthase
NW313_RS02530	COG0067	glutamate synthase
NW313_RS02530	COG0070	glutamate synthase
NW313_RS02530	COG0069	glutamate synthase activity
NW313_RS02540	COG0070	glutamate synthase
NW313_RS02540	COG0069	glutamate synthase activity
NW313_RS02540	COG0067	glutamate synthase
NW313_RS02545	COG1242	4 iron, 4 sulfur cluster binding
NW313_RS02550	COG5001	Diguanylate cyclase
NW313_RS02550	COG2203	Gaf domain
NW313_RS02550	COG3706	GGDEF domain
NW313_RS02550	COG4251	negative regulation of phosphorylation
NW313_RS02555	COG2198	Histidine kinase
NW313_RS02555	COG5002	protein histidine kinase activity
NW313_RS02555	COG0784	Response regulator, receiver
NW313_RS02560	COG0745	RESPONSE REGULATOR receiver
NW313_RS02570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NW313_RS02595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NW313_RS02600	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
NW313_RS02605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NW313_RS02615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NW313_RS02630	COG1115	amino acid carrier protein
NW313_RS02635	COG3022	response to hydroperoxide
NW313_RS02645	COG0084	hydrolase, TatD family'
NW313_RS02650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NW313_RS02660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NW313_RS02665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NW313_RS02670	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NW313_RS02675	COG0813	purine-nucleoside phosphorylase activity
NW313_RS02685	COG0560	Phosphoserine phosphatase
NW313_RS02695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NW313_RS02700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NW313_RS02705	COG1022	Amp-dependent synthetase and ligase
NW313_RS02720	COG3250	beta-galactosidase activity
NW313_RS02725	COG1609	Transcriptional regulator
NW313_RS02730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NW313_RS02745	COG0569	domain protein
NW313_RS02745	COG0189	ligase activity
NW313_RS02750	COG0456	acetyltransferase
NW313_RS02760	COG2171	N-acyltransferase activity
NW313_RS02765	COG3141	response to X-ray
NW313_RS02780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NW313_RS02785	COG1074	ATP-dependent DNA helicase activity
NW313_RS02790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NW313_RS02800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NW313_RS02800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NW313_RS02810	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NW313_RS02815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NW313_RS02820	COG2166	iron-sulfur cluster assembly
NW313_RS02825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NW313_RS02830	COG0693	protein deglycase activity
NW313_RS02835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NW313_RS02840	COG3248	Nucleoside-binding outer membrane protein
NW313_RS02850	COG1595	DNA-templated transcription, initiation
NW313_RS02860	COG2211	Major facilitator Superfamily
NW313_RS02865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NW313_RS02875	COG2813	Specifically methylates the guanine in position
NW313_RS02880	COG0271	Belongs to the BolA IbaG family
NW313_RS02885	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NW313_RS02890	COG1805	sodium ion transport
NW313_RS02895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NW313_RS02900	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NW313_RS02905	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NW313_RS02910	COG2871	sodium ion transport
NW313_RS02915	COG1477	protein flavinylation
NW313_RS02945	COG3328	transposase activity
NW313_RS02950	COG3706	GGDEF domain
NW313_RS02955	COG0733	neurotransmitter:sodium symporter activity
NW313_RS02965	COG0189	ligase activity
NW313_RS02970	COG0189	ligase activity
NW313_RS02970	COG4067	protein conserved in archaea
NW313_RS02975	COG2195	Cleaves the N-terminal amino acid of tripeptides
NW313_RS02980	COG2252	PERMEase
NW313_RS02985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NW313_RS02990	COG1073	alpha beta
NW313_RS03000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NW313_RS03005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NW313_RS03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NW313_RS03015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NW313_RS03015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NW313_RS03030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NW313_RS03035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NW313_RS03040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NW313_RS03045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NW313_RS03055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NW313_RS03060	COG0024	Methionine aminopeptidase
NW313_RS03065	COG0052	Belongs to the universal ribosomal protein uS2 family
NW313_RS03070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NW313_RS03075	COG0528	UMP kinase activity
NW313_RS03080	COG0233	cytoplasmic translational termination
NW313_RS03085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NW313_RS03090	COG0575	Belongs to the CDS family
NW313_RS03095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NW313_RS03100	COG0750	zinc metalloprotease
NW313_RS03110	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
NW313_RS03115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NW313_RS03120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NW313_RS03125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NW313_RS03130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NW313_RS03135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NW313_RS03140	COG0587	DNA-directed DNA polymerase activity
NW313_RS03145	COG0825	malonyl-CoA metabolic process
NW313_RS03150	COG0037	tRNA processing
NW313_RS03160	COG3479	Phenolic acid decarboxylase
NW313_RS03165	COG0347	Belongs to the P(II) protein family
NW313_RS03170	COG3021	interspecies interaction between organisms
NW313_RS03175	COG1388	LysM domain
NW313_RS03175	COG0741	lytic transglycosylase activity
NW313_RS03180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NW313_RS03185	COG2226	methyltransferase
NW313_RS03190	COG0328	RNA-DNA hybrid ribonuclease activity
NW313_RS03205	COG1960	acyl-CoA dehydrogenase activity
NW313_RS03210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NW313_RS03215	COG0121	glutamine amidotransferase
NW313_RS03220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NW313_RS03225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NW313_RS03230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NW313_RS03240	COG1187	pseudouridine synthase activity
NW313_RS03245	COG2840	Smr protein MutS2
NW313_RS03260	COG3735	TraB family
NW313_RS03275	COG2608	mercury ion transmembrane transporter activity
NW313_RS03275	COG2217	Heavy metal translocating P-type atpase
NW313_RS03280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NW313_RS03300	COG1629	transport
NW313_RS03300	COG4774	siderophore transport
NW313_RS03305	COG2375	cellular response to nickel ion
NW313_RS03310	COG3433	isochorismatase activity
NW313_RS03310	COG2226	methyltransferase
NW313_RS03310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NW313_RS03345	COG0784	Response regulator, receiver
NW313_RS03345	COG0835	chemotaxis
NW313_RS03350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NW313_RS03355	COG1815	bacterial-type flagellum-dependent cell motility
NW313_RS03370	COG1749	Flagellar hook protein flgE
NW313_RS03375	COG4787	bacterial-type flagellum-dependent cell motility
NW313_RS03385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NW313_RS03390	COG1706	bacterial-type flagellum-dependent cell motility
NW313_RS03395	COG3951	Flagellar rod assembly protein muramidase FlgJ
NW313_RS03395	COG1705	Flagellar rod assembly protein muramidase FlgJ
NW313_RS03410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NW313_RS03415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NW313_RS03500	COG0012	GTP binding
NW313_RS03505	COG0193	aminoacyl-tRNA hydrolase activity
NW313_RS03510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NW313_RS03515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NW313_RS03520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NW313_RS03525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NW313_RS03530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NW313_RS03535	COG2890	protein-(glutamine-N5) methyltransferase activity
NW313_RS03545	COG2912	Transglutaminase-like superfamily
NW313_RS03550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NW313_RS03555	COG0737	Belongs to the 5'-nucleotidase family
NW313_RS03560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NW313_RS03565	COG2233	PERMEase
NW313_RS03585	COG1393	Belongs to the ArsC family
NW313_RS03590	COG4783	chaperone-mediated protein folding
NW313_RS03610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NW313_RS03625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NW313_RS03635	COG1876	peptidase activity
NW313_RS03645	COG1393	Belongs to the ArsC family
NW313_RS03665	COG2837	iron assimilation
NW313_RS03670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NW313_RS03675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NW313_RS03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NW313_RS03685	COG1334	flagellar protein FlaG
NW313_RS03690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NW313_RS03700	COG1516	flagellar protein fliS
NW313_RS03720	COG1677	Flagellar hook-basal body complex protein FliE
NW313_RS03730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NW313_RS03735	COG1317	bacterial-type flagellum organization
NW313_RS03760	COG1580	Controls the rotational direction of flagella during chemotaxis
NW313_RS03785	COG1987	bacterial-type flagellum assembly
NW313_RS03790	COG1684	flagellar biosynthetic protein fliR
NW313_RS03800	COG2840	Smr protein MutS2
NW313_RS03805	COG2890	protein-(glutamine-N5) methyltransferase activity
NW313_RS03810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NW313_RS03815	COG2860	membrane
NW313_RS03820	COG3101	peptidyl-lysine hydroxylation
NW313_RS03830	COG0431	NADPH-dependent FMN reductase
NW313_RS03840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NW313_RS03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NW313_RS03850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NW313_RS03855	COG0735	belongs to the Fur family
NW313_RS03865	COG0583	DNA-binding transcription factor activity
NW313_RS03875	COG1346	cytolysis
NW313_RS03890	COG0596	Alpha beta hydrolase
NW313_RS03895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NW313_RS03900	COG0033	Phosphoglucomutase
NW313_RS03910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NW313_RS03915	COG0372	Belongs to the citrate synthase family
NW313_RS03920	COG2009	succinate dehydrogenase
NW313_RS03925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NW313_RS03930	COG1053	succinate dehydrogenase
NW313_RS03940	COG0567	Dehydrogenase, E1 component
NW313_RS03945	COG0508	dehydrogenase complex catalyzes the overall conversion of
NW313_RS03950	COG0045	succinate-CoA ligase (ADP-forming) activity
NW313_RS03960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NW313_RS03965	COG1121	(ABC) transporter
NW313_RS03970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NW313_RS03975	COG4977	sequence-specific DNA binding
NW313_RS03980	COG1918	ferrous iron import across plasma membrane
NW313_RS04000	COG0018	arginyl-trna synthetase
NW313_RS04010	COG1025	Belongs to the peptidase M16 family
NW313_RS04015	COG2062	phosphohistidine phosphatase, SixA
NW313_RS04045	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NW313_RS04050	COG0784	Response regulator, receiver
NW313_RS04050	COG0643	Histidine kinase
NW313_RS04050	COG2198	Histidine kinase
NW313_RS04055	COG2201	protein-glutamate methylesterase activity
NW313_RS04060	COG1192	Involved in chromosome partitioning
NW313_RS04070	COG0835	chemotaxis
NW313_RS04080	COG4133	protoheme IX ABC transporter activity
NW313_RS04085	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NW313_RS04090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NW313_RS04100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NW313_RS04105	COG1138	Cytochrome C-type biogenesis protein
NW313_RS04110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NW313_RS04115	COG3088	subunit of a heme lyase
NW313_RS04115	COG4235	cytochrome complex assembly
NW313_RS04125	COG2853	Lipoprotein
NW313_RS04145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NW313_RS04150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NW313_RS04155	COG0123	including yeast histone deacetylase and acetoin utilization protein
NW313_RS04170	COG3083	sulfuric ester hydrolase activity
NW313_RS04175	COG3082	Protein of unknown function (DUF1414)
NW313_RS04180	COG3081	Nucleoid-associated protein
NW313_RS04190	COG1757	Na H antiporter
NW313_RS04195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NW313_RS04200	COG2095	MarC family integral membrane protein
NW313_RS04205	COG1012	belongs to the aldehyde dehydrogenase family
NW313_RS04205	COG1454	alcohol dehydrogenase
NW313_RS04215	COG0659	secondary active sulfate transmembrane transporter activity
NW313_RS04220	COG1530	ribonuclease E activity
NW313_RS04225	COG0564	pseudouridine synthase activity
NW313_RS04230	COG0424	maF-like protein
NW313_RS04235	COG1399	metal-binding, possibly nucleic acid-binding protein
NW313_RS04240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NW313_RS04245	COG0416	fatty acid biosynthetic process
NW313_RS04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NW313_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
NW313_RS04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NW313_RS04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NW313_RS04275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NW313_RS04280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NW313_RS04285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NW313_RS04295	COG0084	hydrolase, TatD family'
NW313_RS04300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NW313_RS04300	COG1263	PTS System
NW313_RS04310	COG0733	neurotransmitter:sodium symporter activity
NW313_RS04325	COG4667	esterase of the alpha-beta hydrolase superfamily
NW313_RS04335	COG1940	carbohydrate kinase activity
NW313_RS04340	COG0784	Response regulator, receiver
NW313_RS04340	COG0835	chemotaxis
NW313_RS04355	COG2226	methyltransferase
NW313_RS04365	COG0676	glucose-6-phosphate 1-epimerase activity
NW313_RS04370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NW313_RS04375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NW313_RS04385	COG3139	Protein of unknown function (DUF1315)
NW313_RS04390	COG0252	asparaginase activity
NW313_RS04395	COG0616	signal peptide processing
NW313_RS04400	COG0446	pyridine nucleotide-disulphide oxidoreductase
NW313_RS04400	COG1902	pentaerythritol trinitrate reductase activity
NW313_RS04405	COG0788	formyltetrahydrofolate deformylase activity
NW313_RS04415	COG1199	ATP-dependent helicase activity
NW313_RS04420	COG1214	PFAM Peptidase M22, glycoprotease
NW313_RS04435	COG0596	Alpha beta hydrolase
NW313_RS04440	COG0318	PFAM AMP-dependent synthetase and ligase
NW313_RS04445	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NW313_RS04465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NW313_RS04470	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NW313_RS04475	COG0436	Aminotransferase
NW313_RS04480	COG1169	isochorismate synthase
NW313_RS04485	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NW313_RS04490	COG0596	Alpha beta hydrolase
NW313_RS04510	COG3135	benzoate transporter
NW313_RS04515	COG1396	sequence-specific DNA binding
NW313_RS04520	COG0840	transmembrane signaling receptor activity
NW313_RS04530	COG0477	Major facilitator Superfamily
NW313_RS04550	COG3015	lipoprotein NlpE involved in copper resistance
NW313_RS04555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NW313_RS04560	COG2894	cell division
NW313_RS04565	COG0850	regulation of cytokinetic process
NW313_RS04570	COG3100	YcgL domain-containing protein
NW313_RS04575	COG2951	lytic endotransglycosylase activity
NW313_RS04585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NW313_RS04590	COG3469	chitinase activity
NW313_RS04590	COG3325	Belongs to the glycosyl hydrolase 18 family
NW313_RS04595	COG3005	denitrification pathway
NW313_RS04600	COG0243	molybdopterin cofactor binding
NW313_RS04615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NW313_RS04625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NW313_RS04660	COG4589	Belongs to the CDS family
NW313_RS04670	COG3300	MHYT domain
NW313_RS04670	COG5001	Diguanylate cyclase
NW313_RS04680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NW313_RS04685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NW313_RS04690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NW313_RS04695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NW313_RS04705	COG4191	Histidine kinase
NW313_RS04715	COG0544	peptidyl-prolyl cis-trans isomerase activity
NW313_RS04725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NW313_RS04730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NW313_RS04735	COG0776	regulation of translation
NW313_RS04740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NW313_RS04745	COG1555	photosystem II stabilization
NW313_RS04750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NW313_RS04755	COG0539	negative regulation of cytoplasmic translation
NW313_RS04760	COG0776	regulation of translation
NW313_RS04765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
NW313_RS04770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NW313_RS04790	COG0583	DNA-binding transcription factor activity
NW313_RS04800	COG0686	Belongs to the AlaDH PNT family
NW313_RS04810	COG1674	ftsk spoiiie
NW313_RS04815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NW313_RS04820	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NW313_RS04825	COG2186	Transcriptional regulator
NW313_RS04840	COG0537	adenosine 5'-monophosphoramidase activity
NW313_RS04865	COG3150	esterase
NW313_RS04870	COG1252	NADH dehydrogenase
NW313_RS04890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NW313_RS04900	COG4591	ABC-type transport system involved in lipoprotein release permease component
NW313_RS04905	COG1136	(ABC) transporter
NW313_RS04910	COG4591	ABC-type transport system involved in lipoprotein release permease component
NW313_RS04920	COG2333	competence protein COMEC
NW313_RS04920	COG0658	competence protein
NW313_RS04925	COG1132	(ABC) transporter
NW313_RS04930	COG1663	tetraacyldisaccharide 4'-kinase activity
NW313_RS04935	COG2835	tetraacyldisaccharide 4'-kinase activity
NW313_RS04940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NW313_RS04945	COG2719	SpoVR family
NW313_RS04950	COG2718	Belongs to the UPF0229 family
NW313_RS04955	COG2766	serine protein kinase
NW313_RS04960	COG3013	Belongs to the UPF0304 family
NW313_RS04970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NW313_RS04975	COG0840	transmembrane signaling receptor activity
NW313_RS04985	COG1882	Formate acetyltransferase
NW313_RS05010	COG4160	amino acid transport
NW313_RS05015	COG0708	Exodeoxyribonuclease III
NW313_RS05020	COG0840	transmembrane signaling receptor activity
NW313_RS05030	COG3923	Primosomal replication protein n
NW313_RS05035	COG0730	response to heat
NW313_RS05040	COG1199	ATP-dependent helicase activity
NW313_RS05045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NW313_RS05050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NW313_RS05055	COG3012	SEC-C Motif Domain Protein
NW313_RS05060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NW313_RS05065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NW313_RS05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NW313_RS05075	COG0215	cysteine-tRNA ligase activity
NW313_RS05080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NW313_RS05085	COG0632	four-way junction helicase activity
NW313_RS05095	COG1271	oxidase subunit
NW313_RS05100	COG1294	oxidase, subunit
NW313_RS05105	COG4890	Cyd operon protein YbgT
NW313_RS05115	COG0824	Thioesterase
NW313_RS05120	COG0811	peptide transport
NW313_RS05135	COG0823	Involved in the tonB-independent uptake of proteins
NW313_RS05140	COG2885	chlorophyll binding
NW313_RS05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NW313_RS05160	COG0784	Response regulator, receiver
NW313_RS05160	COG5002	protein histidine kinase activity
NW313_RS05170	COG1482	cell wall glycoprotein biosynthetic process
NW313_RS05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NW313_RS05175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NW313_RS05175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW313_RS05180	COG2207	Transcriptional regulator
NW313_RS05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NW313_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NW313_RS05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NW313_RS05210	COG1012	belongs to the aldehyde dehydrogenase family
NW313_RS05215	COG3284	Transcriptional regulator
NW313_RS05220	COG4628	conserved protein (DUF2132)
NW313_RS05230	COG0415	Belongs to the DNA photolyase family
NW313_RS05315	COG0488	(ABC) transporter
NW313_RS05355	COG3941	tape measure
NW313_RS05375	COG2003	Belongs to the UPF0758 family
NW313_RS05385	COG4409	exo-alpha-(2->6)-sialidase activity
NW313_RS05390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NW313_RS05395	COG1940	carbohydrate kinase activity
NW313_RS05405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NW313_RS05410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NW313_RS05415	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NW313_RS05420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NW313_RS05425	COG1737	Transcriptional regulator
NW313_RS05430	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NW313_RS05435	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NW313_RS05455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NW313_RS05475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NW313_RS05495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NW313_RS05500	COG0582	viral genome integration into host DNA
NW313_RS05505	COG0582	viral genome integration into host DNA
NW313_RS05520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NW313_RS05530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NW313_RS05530	COG3008	intermembrane lipid transfer
NW313_RS05535	COG2995	paraquat-inducible protein a
NW313_RS05540	COG0668	transmembrane transport
NW313_RS05560	COG1309	transcriptional regulator
NW313_RS05565	COG1012	belongs to the aldehyde dehydrogenase family
NW313_RS05595	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NW313_RS05600	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NW313_RS05625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NW313_RS05630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NW313_RS05635	COG0297	glycogen (starch) synthase activity
NW313_RS05655	COG3070	regulator of competence-specific genes
NW313_RS05660	COG1609	Transcriptional regulator
NW313_RS05665	COG3381	protein complex oligomerization
NW313_RS05670	COG0745	RESPONSE REGULATOR receiver
NW313_RS05675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NW313_RS05680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NW313_RS05690	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NW313_RS05710	COG1032	radical SAM domain protein
NW313_RS05715	COG5001	Diguanylate cyclase
NW313_RS05720	COG0612	Peptidase, M16
NW313_RS05735	COG0583	DNA-binding transcription factor activity
NW313_RS05740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NW313_RS05750	COG2350	Protein conserved in bacteria
NW313_RS05755	COG1607	acyl-coa hydrolase
NW313_RS05770	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NW313_RS05775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NW313_RS05785	COG2116	formate transmembrane transporter activity
NW313_RS05795	COG4459	periplasmic nitrate reductase
NW313_RS05800	COG3005	denitrification pathway
NW313_RS05805	COG0243	molybdopterin cofactor binding
NW313_RS05825	COG1227	inorganic diphosphatase activity
NW313_RS05840	COG4172	Belongs to the ABC transporter superfamily
NW313_RS05855	COG4168	peptide transport system, permease
NW313_RS05865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NW313_RS05870	COG1842	Phage shock protein A
NW313_RS05885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NW313_RS05900	COG2818	Glycosylase
NW313_RS05905	COG0626	cystathionine gamma-synthase activity
NW313_RS05915	COG0733	neurotransmitter:sodium symporter activity
NW313_RS05920	COG0564	pseudouridine synthase activity
NW313_RS05925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NW313_RS05930	COG4136	ATPase activity
NW313_RS05935	COG4135	transport system, permease component
NW313_RS05940	COG4134	Bacterial extracellular solute-binding protein
NW313_RS05950	COG3313	Fe-S protein
NW313_RS05960	COG0842	Transport permease protein
NW313_RS05965	COG1131	(ABC) transporter
NW313_RS05970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NW313_RS05975	COG0814	amino acid
NW313_RS05985	COG2239	Acts as a magnesium transporter
NW313_RS05990	COG2205	protein histidine kinase activity
NW313_RS05990	COG0784	Response regulator, receiver
NW313_RS06005	COG4934	collagen metabolic process
NW313_RS06035	COG0840	transmembrane signaling receptor activity
NW313_RS06045	COG5001	Diguanylate cyclase
NW313_RS06045	COG2203	Gaf domain
NW313_RS06045	COG4251	negative regulation of phosphorylation
NW313_RS06045	COG3706	GGDEF domain
NW313_RS06050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NW313_RS06070	COG1061	Type III restriction enzyme res subunit
NW313_RS06075	COG1187	pseudouridine synthase activity
NW313_RS06080	COG2814	Major facilitator Superfamily
NW313_RS06090	COG0702	epimerase
NW313_RS06095	COG0534	Mate efflux family protein
NW313_RS06100	COG4181	ATPase activity
NW313_RS06105	COG0577	efflux transmembrane transporter activity
NW313_RS06115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NW313_RS06125	COG1748	Saccharopine dehydrogenase
NW313_RS06140	COG1538	Outer membrane efflux protein
NW313_RS06165	COG0583	DNA-binding transcription factor activity
NW313_RS06175	COG1451	nucleotide metabolic process
NW313_RS06180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NW313_RS06190	COG3063	Type IV pilus biogenesis stability protein PilW
NW313_RS06195	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NW313_RS06215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NW313_RS06230	COG3290	protein histidine kinase activity
NW313_RS06235	COG4565	transcriptional regulatory protein
NW313_RS06245	COG0784	Response regulator, receiver
NW313_RS06245	COG0835	chemotaxis
NW313_RS06290	COG1085	galactose-1-phosphate uridylyltransferase
NW313_RS06295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NW313_RS06300	COG2017	converts alpha-aldose to the beta-anomer
NW313_RS06310	COG2199	diguanylate cyclase activity
NW313_RS06310	COG2200	EAL domain
NW313_RS06340	COG0753	catalase activity
NW313_RS06360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NW313_RS06370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NW313_RS06410	COG1271	oxidase subunit
NW313_RS06415	COG1294	oxidase, subunit
NW313_RS06420	COG4591	ABC-type transport system involved in lipoprotein release permease component
NW313_RS06420	COG1136	(ABC) transporter
NW313_RS06425	COG1136	(ABC) transporter
NW313_RS06425	COG0577	efflux transmembrane transporter activity
NW313_RS06430	COG1136	(ABC) transporter
NW313_RS06430	COG0577	efflux transmembrane transporter activity
NW313_RS06450	COG0583	DNA-binding transcription factor activity
NW313_RS06460	COG2723	6-phospho-beta-galactosidase activity
NW313_RS06465	COG1609	Transcriptional regulator
NW313_RS06470	COG0251	oxidation-reduction process
NW313_RS06475	COG2731	YhcH YjgK YiaL family protein
NW313_RS06480	COG0584	glycerophosphoryl diester phosphodiesterase
NW313_RS06485	COG1349	DNA-binding transcription factor activity
NW313_RS06490	COG3842	ATPase activity
NW313_RS06495	COG0395	ABC-type sugar transport system, permease component
NW313_RS06500	COG1175	transmembrane transport
NW313_RS06515	COG0811	peptide transport
NW313_RS06520	COG0811	peptide transport
NW313_RS06525	COG0848	biopolymer transport protein
NW313_RS06530	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NW313_RS06540	COG1793	dna ligase
NW313_RS06550	COG0534	Mate efflux family protein
NW313_RS06560	COG3001	Fructosamine kinase
NW313_RS06570	COG0791	NLP P60 protein
NW313_RS06575	COG0840	transmembrane signaling receptor activity
NW313_RS06585	COG3148	PFAM DTW domain containing protein
NW313_RS06590	COG1940	carbohydrate kinase activity
NW313_RS06615	COG0746	molybdenum cofactor guanylyltransferase activity
NW313_RS06620	COG3842	ATPase activity
NW313_RS06625	COG4662	Binding-protein-dependent transport system inner membrane component
NW313_RS06635	COG2204	response regulator
NW313_RS06640	COG3852	Histidine kinase
NW313_RS06645	COG0488	(ABC) transporter
NW313_RS06650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NW313_RS06680	COG3383	formate dehydrogenase (NAD+) activity
NW313_RS06680	COG0243	molybdopterin cofactor binding
NW313_RS06685	COG0437	4 iron, 4 sulfur cluster binding
NW313_RS06700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NW313_RS06705	COG1666	GTP binding
NW313_RS06710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NW313_RS06725	COG2996	Protein conserved in bacteria
NW313_RS06735	COG3008	intermembrane lipid transfer
NW313_RS06740	COG2995	paraquat-inducible protein a
NW313_RS06745	COG1132	(ABC) transporter
NW313_RS06750	COG1956	GAF domain-containing protein
NW313_RS06755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
NW313_RS06770	COG0308	aminopeptidase N
NW313_RS06785	COG0167	dihydroorotate dehydrogenase activity
NW313_RS06795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NW313_RS06795	COG0116	Belongs to the methyltransferase superfamily
NW313_RS06805	COG0488	(ABC) transporter
NW313_RS06820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NW313_RS06825	COG1067	ATP-dependent peptidase activity
NW313_RS06830	COG3120	sequence-specific DNA binding
NW313_RS06845	COG3328	transposase activity
NW313_RS06910	COG1476	TRANSCRIPTIONal
NW313_RS06930	COG1476	TRANSCRIPTIONal
NW313_RS06960	COG4128	Pfam Zonular occludens toxin
NW313_RS06975	COG1073	alpha beta
NW313_RS06975	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NW313_RS06975	COG3064	Membrane
NW313_RS06980	COG2994	toxin metabolic process
NW313_RS07005	COG0784	Response regulator, receiver
NW313_RS07005	COG2205	protein histidine kinase activity
NW313_RS07020	COG3278	Belongs to the heme-copper respiratory oxidase family
NW313_RS07035	COG2010	Cytochrome c
NW313_RS07045	COG2217	Heavy metal translocating P-type atpase
NW313_RS07060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NW313_RS07065	COG0589	response to stress
NW313_RS07090	COG3842	ATPase activity
NW313_RS07100	COG1177	transmembrane transport
NW313_RS07110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NW313_RS07125	COG1115	amino acid carrier protein
NW313_RS07130	COG1280	lysine exporter protein (LysE YggA)
NW313_RS07145	COG3675	Pfam Lipase (class 3)
NW313_RS07155	COG3501	Rhs element vgr protein
NW313_RS07165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NW313_RS07175	COG2814	Major facilitator Superfamily
NW313_RS07180	COG1566	PFAM secretion protein HlyD family protein
NW313_RS07185	COG1538	Outer membrane efflux protein
NW313_RS07195	COG0513	Belongs to the DEAD box helicase family
NW313_RS07200	COG0840	transmembrane signaling receptor activity
NW313_RS07210	COG0840	transmembrane signaling receptor activity
NW313_RS07215	COG3290	protein histidine kinase activity
NW313_RS07215	COG0840	transmembrane signaling receptor activity
NW313_RS07220	COG0835	chemotaxis
NW313_RS07225	COG2201	protein-glutamate methylesterase activity
NW313_RS07235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NW313_RS07240	COG0784	Response regulator, receiver
NW313_RS07240	COG0643	Histidine kinase
NW313_RS07240	COG2198	Histidine kinase
NW313_RS07245	COG2198	Histidine kinase
NW313_RS07245	COG0643	Histidine kinase
NW313_RS07255	COG0745	RESPONSE REGULATOR receiver
NW313_RS07270	COG0415	Belongs to the DNA photolyase family
NW313_RS07275	COG0477	Major facilitator Superfamily
NW313_RS07280	COG0583	DNA-binding transcription factor activity
NW313_RS07290	COG0095	Lipoate-protein ligase
NW313_RS07295	COG0443	Heat shock 70 kDa protein
NW313_RS07305	COG1643	Atp-dependent helicase
NW313_RS07340	COG0443	Heat shock 70 kDa protein
NW313_RS07345	COG0443	Heat shock 70 kDa protein
NW313_RS07350	COG3706	GGDEF domain
NW313_RS07380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NW313_RS07385	COG0602	queuosine metabolic process
NW313_RS07390	COG0561	phosphatase activity
NW313_RS07400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NW313_RS07405	COG4597	amino acid ABC transporter
NW313_RS07410	COG0765	amino acid transport
NW313_RS07415	COG1126	abc transporter atp-binding protein
NW313_RS07420	COG0670	Belongs to the BI1 family
NW313_RS07425	COG2920	part of a sulfur-relay system
NW313_RS07430	COG1254	Belongs to the acylphosphatase family
NW313_RS07435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NW313_RS07440	COG3706	GGDEF domain
NW313_RS07455	COG3437	response regulator, receiver
NW313_RS07460	COG0625	glutathione transferase activity
NW313_RS07470	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NW313_RS07480	COG2195	Cleaves the N-terminal amino acid of tripeptides
NW313_RS07510	COG0372	Belongs to the citrate synthase family
NW313_RS07515	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NW313_RS07555	COG1129	ABC transporter
NW313_RS07580	COG0745	RESPONSE REGULATOR receiver
NW313_RS07585	COG2205	protein histidine kinase activity
NW313_RS07590	COG3713	MltA-interacting MipA family protein
NW313_RS07595	COG2990	Protein conserved in bacteria
NW313_RS07605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NW313_RS07605	COG4191	Histidine kinase
NW313_RS07610	COG0471	metal ion transport
NW313_RS07620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NW313_RS07635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NW313_RS07645	COG3768	UPF0283 membrane protein
NW313_RS07650	COG3106	COG3106 Predicted ATPase
NW313_RS07665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NW313_RS07670	COG0494	nUDIX hydrolase
NW313_RS07675	COG0814	amino acid
NW313_RS07680	COG1760	l-serine dehydratase
NW313_RS07685	COG0720	synthase
NW313_RS07695	COG0017	Asparaginyl-tRNA synthetase
NW313_RS07700	COG0351	phosphomethylpyrimidine kinase
NW313_RS07705	COG2770	Histidine kinase
NW313_RS07705	COG3437	response regulator, receiver
NW313_RS07710	COG1448	Aminotransferase
NW313_RS07725	COG0840	transmembrane signaling receptor activity
NW313_RS07730	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NW313_RS07735	COG2943	transferase activity, transferring hexosyl groups
NW313_RS07740	COG1609	Transcriptional regulator
NW313_RS07750	COG1486	melibiose metabolic process
NW313_RS07755	COG1447	Phosphotransferase system cellobiose-specific component IIA
NW313_RS07765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NW313_RS07770	COG0726	polysaccharide deacetylase
NW313_RS07775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NW313_RS07780	COG1846	Transcriptional regulator
NW313_RS07805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NW313_RS07820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NW313_RS07825	COG3108	Peptidase M15
NW313_RS07830	COG2989	Protein conserved in bacteria
NW313_RS07855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NW313_RS07865	COG2814	Major facilitator Superfamily
NW313_RS07875	COG1054	Belongs to the UPF0176 family
NW313_RS07885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NW313_RS07890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NW313_RS07895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NW313_RS07945	COG4139	cobalamin transport
NW313_RS07965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NW313_RS07970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NW313_RS07975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NW313_RS07980	COG1823	symporter activity
NW313_RS07985	COG2925	Exonuclease
NW313_RS07990	COG1380	Effector of murein hydrolase LrgA
NW313_RS07995	COG1346	cytolysis
NW313_RS08025	COG0776	regulation of translation
NW313_RS08030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NW313_RS08030	COG0072	phenylalanine-tRNA ligase activity
NW313_RS08035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NW313_RS08075	COG0322	excinuclease ABC activity
NW313_RS08080	COG2197	response regulator
NW313_RS08085	COG0417	DNA replication proofreading
NW313_RS08090	COG5001	Diguanylate cyclase
NW313_RS08100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NW313_RS08105	COG3099	Belongs to the UPF0263 family
NW313_RS08120	COG1228	amidohydrolase
NW313_RS08125	COG0010	Belongs to the arginase family
NW313_RS08130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NW313_RS08135	COG2986	histidine ammonia-lyase
NW313_RS08155	COG0247	lactate metabolic process
NW313_RS08155	COG0277	FAD linked oxidase domain protein
NW313_RS08170	COG2885	chlorophyll binding
NW313_RS08190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NW313_RS08200	COG0281	malic enzyme
NW313_RS08210	COG2949	membrane
NW313_RS08215	COG3706	GGDEF domain
NW313_RS08220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NW313_RS08230	COG0492	ferredoxin-NADP+ reductase activity
NW313_RS08235	COG4988	ABC transporter
NW313_RS08240	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NW313_RS08245	COG1187	pseudouridine synthase activity
NW313_RS08250	COG0009	L-threonylcarbamoyladenylate synthase
NW313_RS08255	COG0613	PHP domain protein
NW313_RS08265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NW313_RS08270	COG0512	Glutamine amidotransferase of anthranilate synthase
NW313_RS08275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NW313_RS08280	COG0134	indole-3-glycerol-phosphate synthase activity
NW313_RS08280	COG0135	phosphoribosylanthranilate isomerase activity
NW313_RS08285	COG0133	tryptophan synthase activity
NW313_RS08290	COG0159	tryptophan synthase activity
NW313_RS08300	COG1435	thymidine kinase activity
NW313_RS08305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NW313_RS08310	COG1801	Protein of unknown function DUF72
NW313_RS08315	COG4106	trans-aconitate 2-methyltransferase activity
NW313_RS08320	COG0500	methyltransferase
NW313_RS08340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NW313_RS08350	COG3852	Histidine kinase
NW313_RS08365	COG3070	regulator of competence-specific genes
NW313_RS08375	COG2431	L-lysine efflux transmembrane transporter activity
NW313_RS08385	COG0076	glutamate decarboxylase activity
NW313_RS08390	COG1737	Transcriptional regulator
NW313_RS08395	COG1454	alcohol dehydrogenase
NW313_RS08395	COG1012	belongs to the aldehyde dehydrogenase family
NW313_RS08400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NW313_RS08405	COG2985	domain, Protein
NW313_RS08405	COG3273	potassium ion transport
NW313_RS08410	COG0542	response to heat
NW313_RS08415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NW313_RS08420	COG1278	Cold shock
NW313_RS08430	COG1187	pseudouridine synthase activity
NW313_RS08435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NW313_RS08435	COG0140	phosphoribosyl-ATP diphosphatase activity
NW313_RS08440	COG0107	imidazoleglycerol-phosphate synthase activity
NW313_RS08445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NW313_RS08450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NW313_RS08455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NW313_RS08455	COG0131	Imidazoleglycerol-phosphate dehydratase
NW313_RS08460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NW313_RS08465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NW313_RS08470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NW313_RS08475	COG1757	Na H antiporter
NW313_RS08480	COG2916	Histone family protein nucleoid-structuring protein H-NS
NW313_RS08485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NW313_RS08490	COG0482	sulfurtransferase activity
NW313_RS08495	COG2915	High frequency lysogenization protein hflD homolog
NW313_RS08500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NW313_RS08510	COG2268	Band 7 protein
NW313_RS08520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NW313_RS08535	COG0300	oxidoreductase activity
NW313_RS08545	COG0501	Belongs to the peptidase M48B family
NW313_RS08555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NW313_RS08560	COG2226	methyltransferase
NW313_RS08565	COG0156	8-amino-7-oxononanoate synthase activity
NW313_RS08570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NW313_RS08575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NW313_RS08580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NW313_RS08585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NW313_RS08590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NW313_RS08600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NW313_RS08605	COG2203	Gaf domain
NW313_RS08605	COG2199	diguanylate cyclase activity
NW313_RS08615	COG4120	Belongs to the binding-protein-dependent transport system permease family
NW313_RS08625	COG4628	conserved protein (DUF2132)
NW313_RS08630	COG3092	negative regulation of chromosome organization
NW313_RS08635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NW313_RS08640	COG0857	belongs to the CobB CobQ family
NW313_RS08640	COG0280	phosphate acetyltransferase
NW313_RS08645	COG0435	Glutathione S-transferase
NW313_RS08650	COG4608	Belongs to the ABC transporter superfamily
NW313_RS08655	COG0444	Belongs to the ABC transporter superfamily
NW313_RS08660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NW313_RS08665	COG0601	transmembrane transport
NW313_RS08685	COG2204	response regulator
NW313_RS08690	COG3300	MHYT domain
NW313_RS08690	COG5001	Diguanylate cyclase
NW313_RS08695	COG4191	Histidine kinase
NW313_RS08700	COG5002	protein histidine kinase activity
NW313_RS08710	COG2201	protein-glutamate methylesterase activity
NW313_RS08725	COG0009	L-threonylcarbamoyladenylate synthase
NW313_RS08740	COG1881	PFAM PEBP family protein
NW313_RS08765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NW313_RS08770	COG0640	Transcriptional regulator
NW313_RS08780	COG3706	GGDEF domain
NW313_RS08800	COG1946	Acyl-CoA thioesterase
NW313_RS08805	COG1522	sequence-specific DNA binding
NW313_RS08815	COG0616	signal peptide processing
NW313_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
NW313_RS08825	COG2983	Belongs to the UPF0260 family
NW313_RS08835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NW313_RS08840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NW313_RS08850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NW313_RS08855	COG2832	Protein of unknown function (DUF454)
NW313_RS08860	COG0745	RESPONSE REGULATOR receiver
NW313_RS08865	COG0583	DNA-binding transcription factor activity
NW313_RS08870	COG0778	Nitroreductase
NW313_RS08875	COG1250	3-hydroxyacyl-CoA dehydrogenase
NW313_RS08875	COG1024	Enoyl-CoA hydratase
NW313_RS08880	COG0183	Belongs to the thiolase family
NW313_RS08895	COG2067	long-chain fatty acid transport protein
NW313_RS08905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NW313_RS08910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NW313_RS08915	COG2982	Protein involved in outer membrane biogenesis
NW313_RS08920	COG0572	uridine kinase
NW313_RS08925	COG0489	protein tyrosine kinase activity
NW313_RS08930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NW313_RS08930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NW313_RS08940	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NW313_RS08950	COG0517	IMP dehydrogenase activity
NW313_RS08950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NW313_RS08950	COG0617	tRNA 3'-terminal CCA addition
NW313_RS08955	COG2199	diguanylate cyclase activity
NW313_RS08960	COG0314	molybdopterin synthase activity
NW313_RS08965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NW313_RS08970	COG0315	cyclic pyranopterin monophosphate synthase activity
NW313_RS08975	COG0521	Mo-molybdopterin cofactor biosynthetic process
NW313_RS08980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NW313_RS08985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NW313_RS08990	COG2198	Histidine kinase
NW313_RS08995	COG2204	response regulator
NW313_RS09000	COG0556	nucleotide-excision repair
NW313_RS09010	COG4657	Part of a membrane complex involved in electron transport
NW313_RS09015	COG2878	Part of a membrane complex involved in electron transport
NW313_RS09020	COG4656	Part of a membrane complex involved in electron transport
NW313_RS09040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NW313_RS09045	COG0346	lactoylglutathione lyase activity
NW313_RS09065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NW313_RS09070	COG2056	Na+-H+ antiporter family
NW313_RS09075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NW313_RS09080	COG1286	toxin biosynthetic process
NW313_RS09085	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NW313_RS09090	COG0285	dihydrofolate synthase activity
NW313_RS09095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NW313_RS09100	COG0101	tRNA pseudouridine synthase activity
NW313_RS09120	COG2190	(PTS) system
NW313_RS09120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NW313_RS09120	COG1263	PTS System
NW313_RS09125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NW313_RS09130	COG1940	carbohydrate kinase activity
NW313_RS09130	COG1846	Transcriptional regulator
NW313_RS09135	COG4651	solute:proton antiporter activity
NW313_RS09135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NW313_RS09140	COG0367	asparagine synthase
NW313_RS09155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NW313_RS09160	COG0563	adenylate kinase activity
NW313_RS09165	COG0326	Molecular chaperone. Has ATPase activity
NW313_RS09170	COG3710	Transcriptional regulator
NW313_RS09185	COG0622	Phosphoesterase
NW313_RS09190	COG1090	epimerase
NW313_RS09195	COG0300	oxidoreductase activity
NW313_RS09200	COG3118	belongs to the thioredoxin family
NW313_RS09205	COG0330	HflC and HflK could
NW313_RS09210	COG1585	Membrane protein implicated in regulation of membrane protease activity
NW313_RS09215	COG0789	Transcriptional regulator
NW313_RS09230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NW313_RS09235	COG3115	cell septum assembly
NW313_RS09240	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NW313_RS09245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NW313_RS09250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW313_RS09260	COG2190	(PTS) system
NW313_RS09265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NW313_RS09270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NW313_RS09275	COG1702	phosphate starvation-inducible protein PhoH
NW313_RS09285	COG4535	Mg2 and Co2 transporter CorC
NW313_RS09290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NW313_RS09295	COG2888	peptidyl-tyrosine sulfation
NW313_RS09300	COG0495	leucyl-tRNA aminoacylation
NW313_RS09305	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NW313_RS09310	COG1466	dna polymerase III delta subunit
NW313_RS09315	COG0799	negative regulation of ribosome biogenesis
NW313_RS09320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NW313_RS09325	COG0768	penicillin binding
NW313_RS09330	COG0772	Belongs to the SEDS family
NW313_RS09335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NW313_RS09340	COG1686	Belongs to the peptidase S11 family
NW313_RS09345	COG2921	Belongs to the UPF0250 family
NW313_RS09350	COG0321	lipoyl(octanoyl) transferase activity
NW313_RS09355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NW313_RS09365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NW313_RS09390	COG1596	polysaccharide export
NW313_RS09400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NW313_RS09430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NW313_RS09440	COG0438	transferase activity, transferring glycosyl groups
NW313_RS09450	COG1045	serine acetyltransferase
NW313_RS09470	COG0110	maltose O-acetyltransferase activity
NW313_RS09475	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NW313_RS09480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NW313_RS09485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NW313_RS09490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NW313_RS09515	COG0366	Alpha amylase catalytic
NW313_RS09520	COG1263	PTS System
NW313_RS09520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NW313_RS09525	COG1609	Transcriptional regulator
NW313_RS09530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NW313_RS09535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NW313_RS09540	COG2011	ABC-type metal ion transport system permease component
NW313_RS09545	COG1464	Belongs to the NlpA lipoprotein family
NW313_RS09550	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NW313_RS09560	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NW313_RS09560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NW313_RS09575	COG1611	Belongs to the LOG family
NW313_RS09580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NW313_RS09585	COG2363	Small membrane protein
NW313_RS09590	COG0583	DNA-binding transcription factor activity
NW313_RS09595	COG0301	tRNA thio-modification
NW313_RS09595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NW313_RS09605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NW313_RS09615	COG1722	exodeoxyribonuclease VII activity
NW313_RS09620	COG0142	geranyltranstransferase activity
NW313_RS09625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NW313_RS09630	COG0564	pseudouridine synthase activity
NW313_RS09635	COG3098	single-species biofilm formation
NW313_RS09650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NW313_RS09660	COG1671	Belongs to the UPF0178 family
NW313_RS09665	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NW313_RS09670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NW313_RS09675	COG0254	rRNA binding
NW313_RS09680	COG1720	tRNA m6t6A37 methyltransferase activity
NW313_RS09685	COG0442	prolyl-tRNA aminoacylation
NW313_RS09710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NW313_RS09710	COG0047	phosphoribosylformylglycinamidine synthase activity
NW313_RS09720	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NW313_RS09735	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NW313_RS09765	COG0484	heat shock protein binding
NW313_RS09770	COG0443	Heat shock 70 kDa protein
NW313_RS09780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NW313_RS09785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NW313_RS09790	COG0497	DNA recombination
NW313_RS09795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NW313_RS09800	COG2914	Belongs to the UPF0125 (RnfH) family
NW313_RS09805	COG2867	negative regulation of translational initiation
NW313_RS09810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NW313_RS09820	COG0582	viral genome integration into host DNA
NW313_RS09830	COG3064	Membrane
NW313_RS09840	COG0739	heme binding
NW313_RS09860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NW313_RS09865	COG2207	Transcriptional regulator
NW313_RS09875	COG1459	type II secretion system
NW313_RS09880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NW313_RS09900	COG4796	Type ii and iii secretion system protein
NW313_RS09915	COG2165	general secretion pathway protein
NW313_RS09925	COG3710	Transcriptional regulator
NW313_RS09930	COG0840	transmembrane signaling receptor activity
NW313_RS09935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NW313_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
NW313_RS10010	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NW313_RS10015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NW313_RS10020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NW313_RS10040	COG3051	citrate lyase alpha subunit
NW313_RS10045	COG2301	Belongs to the HpcH HpaI aldolase family
NW313_RS10055	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
NW313_RS10065	COG3630	sodium ion export across plasma membrane
NW313_RS10070	COG5016	pyruvate
NW313_RS10070	COG0511	ligase activity, forming carbon-carbon bonds
NW313_RS10075	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NW313_RS10085	COG4565	transcriptional regulatory protein
NW313_RS10100	COG0583	DNA-binding transcription factor activity
NW313_RS10110	COG1115	amino acid carrier protein
NW313_RS10115	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NW313_RS10120	COG0583	DNA-binding transcription factor activity
NW313_RS10130	COG1120	ATPase activity
NW313_RS10135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NW313_RS10140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NW313_RS10145	COG4592	Periplasmic binding protein
NW313_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
NW313_RS10160	COG1169	isochorismate synthase
NW313_RS10165	COG1021	2,3-dihydroxybenzoate-AMP ligase
NW313_RS10170	COG1535	isochorismatase
NW313_RS10170	COG3433	isochorismatase activity
NW313_RS10175	COG1584	GPR1 FUN34 yaaH family protein
NW313_RS10185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NW313_RS10185	COG0519	Catalyzes the synthesis of GMP from XMP
NW313_RS10190	COG0516	GMP reductase activity
NW313_RS10190	COG0517	IMP dehydrogenase activity
NW313_RS10195	COG1570	exodeoxyribonuclease VII activity
NW313_RS10210	COG1160	GTP binding
NW313_RS10215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NW313_RS10220	COG2976	Protein conserved in bacteria
NW313_RS10225	COG0124	histidyl-tRNA synthetase
NW313_RS10230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NW313_RS10240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NW313_RS10245	COG0105	UTP biosynthetic process
NW313_RS10250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NW313_RS10255	COG2975	iron-sulfur cluster assembly
NW313_RS10260	COG0633	Ferredoxin
NW313_RS10265	COG0443	Heat shock 70 kDa protein
NW313_RS10270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NW313_RS10280	COG0822	iron-sulfur transferase activity
NW313_RS10285	COG1104	cysteine desulfurase activity
NW313_RS10290	COG1959	2 iron, 2 sulfur cluster binding
NW313_RS10300	COG0483	inositol monophosphate 1-phosphatase activity
NW313_RS10305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NW313_RS10310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NW313_RS10315	COG1862	Preprotein translocase
NW313_RS10330	COG0517	IMP dehydrogenase activity
NW313_RS10340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NW313_RS10345	COG0583	DNA-binding transcription factor activity
NW313_RS10350	COG0450	alkyl hydroperoxide reductase
NW313_RS10355	COG3142	Participates in the control of copper homeostasis
NW313_RS10370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NW313_RS10375	COG0581	inorganic phosphate transmembrane transporter activity
NW313_RS10385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NW313_RS10390	COG0248	Ppx GppA phosphatase
NW313_RS10400	COG5002	protein histidine kinase activity
NW313_RS10405	COG0745	RESPONSE REGULATOR receiver
NW313_RS10415	COG0826	peptidase U32
NW313_RS10420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NW313_RS10460	COG0542	response to heat
NW313_RS10470	COG0564	pseudouridine synthase activity
NW313_RS10475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NW313_RS10480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NW313_RS10485	COG0077	Prephenate dehydratase
NW313_RS10485	COG1605	Chorismate mutase
NW313_RS10490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NW313_RS10495	COG5001	Diguanylate cyclase
NW313_RS10505	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
NW313_RS10515	COG0488	(ABC) transporter
NW313_RS10525	COG0287	Prephenate dehydrogenase
NW313_RS10525	COG1605	Chorismate mutase
NW313_RS10530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NW313_RS10535	COG3275	phosphorelay sensor kinase activity
NW313_RS10540	COG3279	Response regulator of the LytR AlgR family
NW313_RS10550	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NW313_RS10555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NW313_RS10570	COG1966	Carbon starvation protein
NW313_RS10575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NW313_RS10580	COG1047	Peptidyl-prolyl cis-trans
NW313_RS10595	COG0196	riboflavin kinase activity
NW313_RS10600	COG0728	peptidoglycan biosynthetic process
NW313_RS10605	COG0268	Binds directly to 16S ribosomal RNA
NW313_RS10610	COG0640	Transcriptional regulator
NW313_RS10615	COG0583	DNA-binding transcription factor activity
NW313_RS10620	COG1283	sodium-dependent phosphate transmembrane transporter activity
NW313_RS10630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NW313_RS10635	COG0730	response to heat
NW313_RS10640	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NW313_RS10645	COG0494	nUDIX hydrolase
NW313_RS10655	COG0667	Aldo Keto reductase
NW313_RS10665	COG2204	response regulator
NW313_RS10670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NW313_RS10690	COG0513	Belongs to the DEAD box helicase family
NW313_RS10805	COG2003	Belongs to the UPF0758 family
NW313_RS10830	COG0714	Associated with various cellular activities
NW313_RS10850	COG0629	single-stranded DNA binding
NW313_RS10865	COG2356	endonuclease I
NW313_RS10905	COG0681	Belongs to the peptidase S26 family
NW313_RS10920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NW313_RS11050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NW313_RS11065	COG3328	transposase activity
NW313_RS11180	COG3153	acetyltransferase
NW313_RS11185	COG3154	lipid carrier protein
NW313_RS11195	COG0826	peptidase U32
NW313_RS11200	COG0826	peptidase U32
NW313_RS11225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NW313_RS11235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NW313_RS11240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NW313_RS11245	COG0195	Participates in both transcription termination and antitermination
NW313_RS11250	COG0779	Required for maturation of 30S ribosomal subunits
NW313_RS11265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NW313_RS11275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NW313_RS11280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NW313_RS11285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NW313_RS11290	COG1534	Rna-binding protein
NW313_RS11295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NW313_RS11300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NW313_RS11305	COG2027	D-alanyl-D-alanine carboxypeptidase
NW313_RS11310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NW313_RS11315	COG0739	heme binding
NW313_RS11330	COG0316	Belongs to the HesB IscA family
NW313_RS11335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NW313_RS11340	COG0628	permease
NW313_RS11345	COG2813	Specifically methylates the guanine in position
NW313_RS11350	COG0784	Response regulator, receiver
NW313_RS11350	COG2205	protein histidine kinase activity
NW313_RS11355	COG0747	negative chemotaxis
NW313_RS11360	COG0601	transmembrane transport
NW313_RS11365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NW313_RS11370	COG0444	Belongs to the ABC transporter superfamily
NW313_RS11375	COG4608	Belongs to the ABC transporter superfamily
NW313_RS11385	COG2971	BadF BadG BcrA BcrD
NW313_RS11405	COG3842	ATPase activity
NW313_RS11415	COG1840	ABC-type Fe3 transport system, periplasmic component
NW313_RS11420	COG0004	ammonium transporteR
NW313_RS11425	COG0347	Belongs to the P(II) protein family
NW313_RS11430	COG3112	Uncharacterised protein family (UPF0231)
NW313_RS11435	COG1049	propionate catabolic process, 2-methylcitrate cycle
NW313_RS11440	COG1752	Esterase of the alpha-beta hydrolase superfamily
NW313_RS11445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NW313_RS11450	COG1643	Atp-dependent helicase
NW313_RS11460	COG1489	DNA binding
NW313_RS11470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NW313_RS11480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NW313_RS11485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NW313_RS11490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NW313_RS11495	COG0842	Transport permease protein
NW313_RS11500	COG1131	(ABC) transporter
NW313_RS11505	COG0659	secondary active sulfate transmembrane transporter activity
NW313_RS11510	COG0288	reversible hydration of carbon dioxide
NW313_RS11525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NW313_RS11530	COG3107	peptidoglycan biosynthetic process
NW313_RS11535	COG0792	nuclease activity
NW313_RS11540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NW313_RS11545	COG2823	Periplasmic or secreted lipoprotein
NW313_RS11550	COG2969	positive regulation of protein catabolic process
NW313_RS11555	COG0625	glutathione transferase activity
NW313_RS11560	COG2857	Cytochrome c1
NW313_RS11565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NW313_RS11570	COG0723	plastoquinol--plastocyanin reductase activity
NW313_RS11575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NW313_RS11580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NW313_RS11585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NW313_RS11595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NW313_RS11600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NW313_RS11605	COG0335	large ribosomal subunit rRNA binding
NW313_RS11610	COG0336	Belongs to the RNA methyltransferase TrmD family
NW313_RS11615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NW313_RS11620	COG0228	four-way junction DNA binding
NW313_RS11625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NW313_RS11630	COG4137	Cytochrome C assembly protein
NW313_RS11635	COG4536	flavin adenine dinucleotide binding
NW313_RS11640	COG1854	S-ribosylhomocysteine lyase activity
NW313_RS11645	COG2918	glutathione biosynthetic process
NW313_RS11650	COG0612	Peptidase, M16
NW313_RS11655	COG1238	metal cluster binding
NW313_RS11665	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NW313_RS11670	COG5016	pyruvate
NW313_RS11670	COG0511	ligase activity, forming carbon-carbon bonds
NW313_RS11675	COG3630	sodium ion export across plasma membrane
NW313_RS11710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NW313_RS11715	COG0527	aspartate kinase activity
NW313_RS11720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NW313_RS11730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NW313_RS11740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NW313_RS11745	COG4208	sulfate ABC transporter
NW313_RS11765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NW313_RS11770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NW313_RS11780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NW313_RS11785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NW313_RS11790	COG0585	pseudouridine synthase activity
NW313_RS11795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NW313_RS11800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NW313_RS11805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NW313_RS11810	COG1968	undecaprenyl-diphosphatase activity
NW313_RS11815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NW313_RS11820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NW313_RS11825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NW313_RS11835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NW313_RS11840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NW313_RS11845	COG1610	YqeY-like protein
NW313_RS11850	COG0358	DNA primase activity
NW313_RS11865	COG0582	viral genome integration into host DNA
NW313_RS11870	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NW313_RS11880	COG2207	Transcriptional regulator
NW313_RS11925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NW313_RS11930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NW313_RS11935	COG1349	DNA-binding transcription factor activity
NW313_RS11955	COG1279	arginine transmembrane transporter activity
NW313_RS11960	COG0668	transmembrane transport
NW313_RS11965	COG0191	fructose-bisphosphate aldolase activity
NW313_RS11970	COG0126	phosphoglycerate kinase activity
NW313_RS11975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NW313_RS11980	COG4771	TonB-dependent receptor
NW313_RS11985	COG0583	DNA-binding transcription factor activity
NW313_RS11990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NW313_RS11995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NW313_RS12005	COG2356	endonuclease I
NW313_RS12010	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NW313_RS12015	COG0189	ligase activity
NW313_RS12020	COG1678	Uncharacterized ACR, COG1678
NW313_RS12025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NW313_RS12030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NW313_RS12050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NW313_RS12055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NW313_RS12060	COG0762	integral membrane protein
NW313_RS12065	COG1872	DUF167
NW313_RS12075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NW313_RS12080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NW313_RS12085	COG2066	Belongs to the glutaminase family
NW313_RS12095	COG1194	a g-specific adenine glycosylase
NW313_RS12100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NW313_RS12105	COG0741	lytic transglycosylase activity
NW313_RS12160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NW313_RS12165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NW313_RS12170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NW313_RS12175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NW313_RS12180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NW313_RS12185	COG2967	ApaG domain
NW313_RS12190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NW313_RS12200	COG3610	response to peptide
NW313_RS12205	COG2966	Psort location CytoplasmicMembrane, score
NW313_RS12210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NW313_RS12215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NW313_RS12220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NW313_RS12225	COG0142	geranyltranstransferase activity
NW313_RS12235	COG0039	L-malate dehydrogenase activity
NW313_RS12240	COG1438	arginine binding
NW313_RS12245	COG2358	TRAP transporter, solute receptor (TAXI family
NW313_RS12255	COG0589	response to stress
NW313_RS12275	COG2235	arginine
NW313_RS12280	COG0312	modulator of DNA gyrase
NW313_RS12285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NW313_RS12290	COG3164	Protein of unknown function
NW313_RS12300	COG0424	maF-like protein
NW313_RS12305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NW313_RS12310	COG1792	Involved in formation and maintenance of cell shape
NW313_RS12315	COG1077	Cell shape determining protein MreB Mrl
NW313_RS12345	COG2165	general secretion pathway protein
NW313_RS12350	COG2165	general secretion pathway protein
NW313_RS12360	COG1459	type II secretion system
NW313_RS12365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NW313_RS12375	COG3409	Peptidoglycan-binding domain 1 protein
NW313_RS12375	COG3267	Type II secretory pathway component ExeA
NW313_RS12400	COG2199	diguanylate cyclase activity
NW313_RS12400	COG2200	EAL domain
NW313_RS12405	COG0629	single-stranded DNA binding
NW313_RS12420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NW313_RS12430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NW313_RS12435	COG0527	aspartate kinase activity
NW313_RS12440	COG0646	methionine synthase
NW313_RS12440	COG1410	methionine synthase
NW313_RS12510	COG0175	sulfate reduction
NW313_RS12520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NW313_RS12545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NW313_RS12550	COG0735	belongs to the Fur family
NW313_RS12570	COG0432	Pfam Uncharacterised protein family UPF0047
NW313_RS12575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NW313_RS12590	COG0359	binds to the 23S rRNA
NW313_RS12595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NW313_RS12600	COG2965	DNA replication, synthesis of RNA primer
NW313_RS12605	COG0360	Binds together with S18 to 16S ribosomal RNA
NW313_RS12615	COG2906	2 iron, 2 sulfur cluster binding
NW313_RS12620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NW313_RS12625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NW313_RS12630	COG0049	tRNA binding
NW313_RS12645	COG2923	Belongs to the DsrF TusC family
NW313_RS12650	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NW313_RS12655	COG2964	Protein conserved in bacteria
NW313_RS12660	COG0545	Peptidyl-prolyl cis-trans isomerase
NW313_RS12670	COG2900	Belongs to the SlyX family
NW313_RS12675	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NW313_RS12680	COG0330	HflC and HflK could
NW313_RS12685	COG0330	HflC and HflK could
NW313_RS12690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NW313_RS12695	COG1923	regulation of RNA biosynthetic process
NW313_RS12700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NW313_RS12705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NW313_RS12715	COG0802	atpase or kinase
NW313_RS12720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NW313_RS12760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NW313_RS12765	COG1162	GTPase activity
NW313_RS12770	COG0688	phosphatidylethanolamine metabolic process
NW313_RS12775	COG0471	metal ion transport
NW313_RS12785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NW313_RS12790	COG4942	peptidase
NW313_RS12805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NW313_RS12810	COG2816	NAD+ diphosphatase activity
NW313_RS12815	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
NW313_RS12820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NW313_RS12825	COG0085	RNA polymerase activity
NW313_RS12830	COG0222	ribosome binding
NW313_RS12835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NW313_RS12845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NW313_RS12850	COG0250	Participates in transcription elongation, termination and antitermination
NW313_RS12855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NW313_RS12860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NW313_RS12885	COG1072	(Pantothenic acid kinase))
NW313_RS12895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NW313_RS12905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NW313_RS12950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NW313_RS12965	COG3118	belongs to the thioredoxin family
NW313_RS12970	COG0513	Belongs to the DEAD box helicase family
NW313_RS12975	COG0248	Ppx GppA phosphatase
NW313_RS12980	COG0784	Response regulator, receiver
NW313_RS12980	COG2205	protein histidine kinase activity
NW313_RS12985	COG2814	Major facilitator Superfamily
NW313_RS13000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NW313_RS13005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NW313_RS13010	COG0511	ligase activity, forming carbon-carbon bonds
NW313_RS13015	COG0439	Biotin carboxylase
NW313_RS13020	COG2264	protein methyltransferase activity
NW313_RS13025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NW313_RS13030	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NW313_RS13035	COG1609	Transcriptional regulator
NW313_RS13040	COG0129	dihydroxy-acid dehydratase activity
NW313_RS13045	COG3265	gluconokinase activity
NW313_RS13055	COG0800	Aldolase
NW313_RS13075	COG0840	transmembrane signaling receptor activity
NW313_RS13080	COG1982	Orn Lys Arg decarboxylase major
NW313_RS13085	COG0531	amino acid
NW313_RS13090	COG3710	Transcriptional regulator
NW313_RS13095	COG0789	Transcriptional regulator
NW313_RS13110	COG0151	Belongs to the GarS family
NW313_RS13120	COG0776	regulation of translation
NW313_RS13125	COG1253	flavin adenine dinucleotide binding
NW313_RS13130	COG1940	carbohydrate kinase activity
NW313_RS13140	COG3068	Protein conserved in bacteria
NW313_RS13150	COG1573	uracil-dna glycosylase
NW313_RS13155	COG0668	transmembrane transport
NW313_RS13160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NW313_RS13165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NW313_RS13210	COG1454	alcohol dehydrogenase
NW313_RS13210	COG1012	belongs to the aldehyde dehydrogenase family
NW313_RS13215	COG0318	PFAM AMP-dependent synthetase and ligase
NW313_RS13245	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NW313_RS13250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NW313_RS13255	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NW313_RS13255	COG0662	Cupin 2, conserved barrel domain protein
NW313_RS13260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NW313_RS13295	COG1519	Transferase
NW313_RS13325	COG3642	lipopolysaccharide core region biosynthetic process
NW313_RS13330	COG0859	PFAM glycosyl transferase family 9
NW313_RS13335	COG0463	Glycosyl transferase, family 2
NW313_RS13340	COG0859	PFAM glycosyl transferase family 9
NW313_RS13345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NW313_RS13350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NW313_RS13360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NW313_RS13365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NW313_RS13370	COG2003	Belongs to the UPF0758 family
NW313_RS13380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NW313_RS13390	COG1309	transcriptional regulator
NW313_RS13395	COG1560	Kdo2-lipid A biosynthetic process
NW313_RS13400	COG1560	Kdo2-lipid A biosynthetic process
NW313_RS13405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NW313_RS13410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NW313_RS13415	COG1561	YicC-like family, N-terminal region
NW313_RS13420	COG2862	Uncharacterized protein family, UPF0114
NW313_RS13425	COG1263	PTS System
NW313_RS13425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NW313_RS13430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NW313_RS13450	COG1120	ATPase activity
NW313_RS13455	COG4774	siderophore transport
NW313_RS13460	COG1132	(ABC) transporter
NW313_RS13475	COG0514	ATP-dependent DNA helicase (RecQ)
NW313_RS13480	COG2962	Rard protein
NW313_RS13495	COG1280	lysine exporter protein (LysE YggA)
NW313_RS13500	COG0210	DNA helicase
NW313_RS13510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NW313_RS13515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NW313_RS13555	COG3621	Patatin-like phospholipase
NW313_RS13580	COG2131	deaminase
NW313_RS13590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NW313_RS13595	COG0601	transmembrane transport
NW313_RS13600	COG0747	negative chemotaxis
NW313_RS13650	COG1309	transcriptional regulator
NW313_RS13655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NW313_RS13660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NW313_RS13665	COG2960	long-chain fatty acid transporting porin activity
NW313_RS13670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NW313_RS13675	COG0583	DNA-binding transcription factor activity
NW313_RS13720	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NW313_RS13725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NW313_RS13730	COG1739	Uncharacterized protein family UPF0029
NW313_RS13740	COG0183	Belongs to the thiolase family
NW313_RS13745	COG0583	DNA-binding transcription factor activity
NW313_RS13750	COG2814	Major facilitator Superfamily
NW313_RS13755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NW313_RS13760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NW313_RS13765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NW313_RS13770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NW313_RS13775	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NW313_RS13780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NW313_RS13785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NW313_RS13795	COG0356	it plays a direct role in the translocation of protons across the membrane
NW313_RS13800	COG3312	ion transport
NW313_RS13805	COG1475	DNA binding
NW313_RS13810	COG1192	Involved in chromosome partitioning
NW313_RS13820	COG0445	tRNA wobble uridine modification
NW313_RS13825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NW313_RS13830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NW313_RS13835	COG0706	membrane insertase activity
NW313_RS13845	COG0594	ribonuclease P activity
NW313_RS13850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NW313_RS13855	COG1126	abc transporter atp-binding protein
NW313_RS13895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NW313_RS13900	COG4149	molybdate abc transporter
NW313_RS13905	COG0725	ABC transporter, periplasmic molybdate-binding protein
NW313_RS13910	COG1492	cobalamin metabolic process
NW313_RS13950	COG0784	Response regulator, receiver
NW313_RS13950	COG5002	protein histidine kinase activity
NW313_RS13955	COG1879	ABC-type sugar transport system periplasmic component
NW313_RS13965	COG2827	Endonuclease containing a URI domain
NW313_RS13980	COG2926	Belongs to the UPF0265 family
NW313_RS13990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NW313_RS13995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NW313_RS14000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NW313_RS14005	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NW313_RS14010	COG0247	lactate metabolic process
NW313_RS14015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NW313_RS14020	COG3118	belongs to the thioredoxin family
NW313_RS14050	COG0583	DNA-binding transcription factor activity
NW313_RS14055	COG4160	amino acid transport
NW313_RS14060	COG4215	(ABC) transporter
NW313_RS14065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NW313_RS14070	COG1126	abc transporter atp-binding protein
NW313_RS14080	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NW313_RS14090	COG0494	nUDIX hydrolase
NW313_RS14095	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NW313_RS14105	COG1309	transcriptional regulator
NW313_RS14110	COG0513	Belongs to the DEAD box helicase family
NW313_RS14115	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NW313_RS14120	COG0814	amino acid
NW313_RS14125	COG0840	transmembrane signaling receptor activity
NW313_RS14130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NW313_RS14135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NW313_RS14145	COG1984	allophanate hydrolase subunit 2
NW313_RS14160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NW313_RS14165	COG4181	ATPase activity
NW313_RS14175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NW313_RS14180	COG1716	ATPase activity
NW313_RS14180	COG5001	Diguanylate cyclase
NW313_RS14190	COG0484	heat shock protein binding
NW313_RS14230	COG0546	phosphoglycolate phosphatase activity
NW313_RS14245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NW313_RS14250	COG1368	sulfuric ester hydrolase activity
NW313_RS14260	COG0513	Belongs to the DEAD box helicase family
NW313_RS14275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NW313_RS14285	COG3046	protein related to deoxyribodipyrimidine photolyase
NW313_RS14290	COG3397	chitin binding
NW313_RS14295	COG3227	Zinc metalloprotease (Elastase)
NW313_RS14305	COG0010	Belongs to the arginase family
NW313_RS14310	COG1166	arginine decarboxylase activity
NW313_RS14320	COG2239	Acts as a magnesium transporter
NW313_RS14325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NW313_RS14330	COG0459	protein refolding
NW313_RS14340	COG0527	aspartate kinase activity
NW313_RS14345	COG0662	Cupin 2, conserved barrel domain protein
NW313_RS14350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NW313_RS14355	COG0456	acetyltransferase
NW313_RS14365	COG3186	Phenylalanine-4-hydroxylase
NW313_RS14370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NW313_RS14385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NW313_RS14410	COG1253	flavin adenine dinucleotide binding
NW313_RS14415	COG1765	OsmC-like protein
NW313_RS14440	COG0531	amino acid
NW313_RS14455	COG3279	Response regulator of the LytR AlgR family
NW313_RS14460	COG3275	phosphorelay sensor kinase activity
NW313_RS14475	COG0577	efflux transmembrane transporter activity
NW313_RS14475	COG1136	(ABC) transporter
NW313_RS14480	COG1136	(ABC) transporter
NW313_RS14495	COG4989	oxidoreductase activity
NW313_RS14500	COG0366	Alpha amylase catalytic
NW313_RS14510	COG2067	long-chain fatty acid transport protein
NW313_RS14515	COG2267	carboxylic ester hydrolase activity
NW313_RS14525	COG3227	Zinc metalloprotease (Elastase)
NW313_RS14535	COG3047	cAMP biosynthetic process
NW313_RS14545	COG1686	Belongs to the peptidase S11 family
NW313_RS14550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NW313_RS14555	COG1271	oxidase subunit
NW313_RS14560	COG1294	oxidase, subunit
NW313_RS14575	COG3048	D-serine ammonia-lyase activity
NW313_RS14580	COG0583	DNA-binding transcription factor activity
NW313_RS14635	COG1063	alcohol dehydrogenase
NW313_RS14665	COG0346	lactoylglutathione lyase activity
NW313_RS14685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NW313_RS14690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NW313_RS14695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NW313_RS14700	COG0363	glucosamine-6-phosphate deaminase activity
NW313_RS14705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NW313_RS14730	COG1929	Belongs to the glycerate kinase type-1 family
NW313_RS14735	COG2610	gluconate transmembrane transporter activity
NW313_RS14740	COG3835	regulator
NW313_RS14750	COG0748	coenzyme F420 binding
NW313_RS14755	COG3721	Heme iron utilization protein
NW313_RS14765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NW313_RS14770	COG0811	peptide transport
NW313_RS14775	COG0848	biopolymer transport protein
NW313_RS14780	COG4558	Periplasmic binding protein
NW313_RS14785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NW313_RS14790	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NW313_RS14825	COG3217	Mosc domain protein beta barrel domain protein
NW313_RS14825	COG0633	Ferredoxin
NW313_RS14825	COG3217	Mosc domain protein beta barrel domain protein
NW313_RS14825	COG0633	Ferredoxin
NW313_RS14830	COG0418	dihydroorotase activity
NW313_RS14840	COG3152	Membrane
NW313_RS14850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NW313_RS14855	COG2354	Protein conserved in bacteria
NW313_RS14860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NW313_RS14865	COG1278	Cold shock
NW313_RS14890	COG2199	diguanylate cyclase activity
NW313_RS14895	COG1349	DNA-binding transcription factor activity
NW313_RS14910	COG3833	ABC-type maltose transport systems, permease component
NW313_RS14915	COG1175	transmembrane transport
NW313_RS14925	COG3842	ATPase activity
NW313_RS14930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NW313_RS14945	COG0393	Putative heavy-metal-binding
NW313_RS14955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NW313_RS14960	COG0784	Response regulator, receiver
NW313_RS14960	COG0835	chemotaxis
NW313_RS14965	COG1846	Transcriptional regulator
NW313_RS14970	COG3706	GGDEF domain
NW313_RS15005	COG0583	DNA-binding transcription factor activity
NW313_RS15010	COG5001	Diguanylate cyclase
NW313_RS15020	COG1741	Belongs to the pirin family
NW313_RS15025	COG3123	guanosine phosphorylase activity
NW313_RS15035	COG2211	Major facilitator Superfamily
NW313_RS15040	COG0840	transmembrane signaling receptor activity
NW313_RS15045	COG1067	ATP-dependent peptidase activity
NW313_RS15055	COG4172	Belongs to the ABC transporter superfamily
NW313_RS15080	COG0583	DNA-binding transcription factor activity
NW313_RS15090	COG1620	l-lactate permease
NW313_RS15105	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NW313_RS15115	COG0840	transmembrane signaling receptor activity
NW313_RS15125	COG0513	Belongs to the DEAD box helicase family
NW313_RS15130	COG0583	DNA-binding transcription factor activity
NW313_RS15140	COG1902	pentaerythritol trinitrate reductase activity
NW313_RS15150	COG1132	(ABC) transporter
NW313_RS15160	COG1902	pentaerythritol trinitrate reductase activity
NW313_RS15170	COG1280	lysine exporter protein (LysE YggA)
NW313_RS15175	COG2207	Transcriptional regulator
NW313_RS15195	COG1846	Transcriptional regulator
NW313_RS15200	COG1764	response to oxidative stress
NW313_RS15205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NW313_RS15210	COG0697	spore germination
NW313_RS15220	COG0700	Nucleoside recognition
NW313_RS15225	COG3366	ferrous iron transmembrane transporter activity
NW313_RS15230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NW313_RS15240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NW313_RS15245	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NW313_RS15250	COG2259	Doxx family
NW313_RS15275	COG0363	glucosamine-6-phosphate deaminase activity
NW313_RS15290	COG4580	involved in the transport of maltose and maltodextrins
NW313_RS15305	COG0840	transmembrane signaling receptor activity
NW313_RS15320	COG0840	transmembrane signaling receptor activity
NW313_RS15330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NW313_RS15335	COG1126	abc transporter atp-binding protein
NW313_RS15345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NW313_RS15350	COG4597	amino acid ABC transporter
NW313_RS15355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NW313_RS15365	COG0739	heme binding
NW313_RS15370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW313_RS15370	COG2213	PTS system mannitol-specific
NW313_RS15375	COG0246	Mannitol dehydrogenase
NW313_RS15380	COG3722	fumarate hydratase activity
NW313_RS15385	COG0673	inositol 2-dehydrogenase activity
NW313_RS15415	COG2910	NAD(P)H-binding
NW313_RS15425	COG0840	transmembrane signaling receptor activity
NW313_RS15430	COG4221	oxidoreductase activity
NW313_RS15440	COG1901	pseudouridine methyltransferase
NW313_RS15455	COG0531	amino acid
NW313_RS15460	COG1982	Orn Lys Arg decarboxylase major
NW313_RS15490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NW313_RS15515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NW313_RS15555	COG0745	RESPONSE REGULATOR receiver
NW313_RS15580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NW313_RS15590	COG0835	chemotaxis
NW313_RS15595	COG0835	chemotaxis
NW313_RS15600	COG0643	Histidine kinase
NW313_RS15600	COG2198	Histidine kinase
NW313_RS15605	COG0643	Histidine kinase
NW313_RS15605	COG2198	Histidine kinase
NW313_RS15625	COG0601	transmembrane transport
NW313_RS15630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NW313_RS15640	COG2194	sulfuric ester hydrolase activity
NW313_RS15645	COG0642	Histidine kinase
NW313_RS15680	COG1444	tRNA N-acetyltransferase activity
NW313_RS15685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NW313_RS15720	COG0217	transcriptional regulatory protein
NW313_RS15725	COG2084	Dehydrogenase
NW313_RS15740	COG2909	trisaccharide binding
NW313_RS15745	COG0058	SHG alpha-glucan phosphorylase activity
NW313_RS15750	COG1640	4-alpha-glucanotransferase
NW313_RS15755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NW313_RS15765	COG3501	Rhs element vgr protein
NW313_RS15770	COG4104	PAAR repeat-containing protein
NW313_RS15800	COG0471	metal ion transport
NW313_RS15805	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NW313_RS15845	COG0671	phosphoesterase, PA-phosphatase related
NW313_RS15850	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NW313_RS15860	COG1999	signal sequence binding
NW313_RS15875	COG0786	glutamate:sodium symporter activity
NW313_RS15895	COG1566	PFAM secretion protein HlyD family protein
NW313_RS15920	COG0813	purine-nucleoside phosphorylase activity
NW313_RS15925	COG3272	Protein of unknown function (DUF1722)
NW313_RS15935	COG0415	Belongs to the DNA photolyase family
NW313_RS15940	COG1376	ErfK ybiS ycfS ynhG family protein
NW313_RS15940	COG1388	LysM domain
NW313_RS15950	COG0513	Belongs to the DEAD box helicase family
NW313_RS15955	COG1770	oligopeptidase
NW313_RS15985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NW313_RS15990	COG0573	inorganic phosphate transmembrane transporter activity
NW313_RS15995	COG0581	inorganic phosphate transmembrane transporter activity
NW313_RS16000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NW313_RS16020	COG3314	Sporulation integral membrane protein YlbJ
NW313_RS16025	COG0659	secondary active sulfate transmembrane transporter activity
NW313_RS16035	COG0739	heme binding
NW313_RS16040	COG3300	MHYT domain
NW313_RS16040	COG5001	Diguanylate cyclase
NW313_RS16045	COG0583	DNA-binding transcription factor activity
NW313_RS16050	COG2814	Major facilitator Superfamily
NW313_RS16075	COG1301	dicarboxylic acid transport
NW313_RS16085	COG1342	Belongs to the UPF0251 family
NW313_RS16115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NW313_RS16120	COG0673	inositol 2-dehydrogenase activity
NW313_RS16130	COG2200	EAL domain
NW313_RS16130	COG2771	luxR family
NW313_RS16135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NW313_RS16145	COG0564	pseudouridine synthase activity
NW313_RS16210	COG3829	transcription factor binding
NW313_RS16235	COG3409	Peptidoglycan-binding domain 1 protein
NW313_RS16235	COG3501	Rhs element vgr protein
NW313_RS16250	COG1869	D-ribose catabolic process
NW313_RS16255	COG1129	ABC transporter
NW313_RS16260	COG1172	Belongs to the binding-protein-dependent transport system permease family
NW313_RS16265	COG1879	ABC-type sugar transport system periplasmic component
NW313_RS16270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NW313_RS16275	COG1609	Transcriptional regulator
NW313_RS16285	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NW313_RS16295	COG0584	glycerophosphoryl diester phosphodiesterase
NW313_RS16300	COG2271	Major facilitator Superfamily
NW313_RS16335	COG0579	oxidoreductase
NW313_RS16345	COG0242	peptide deformylase activity
NW313_RS16355	COG1320	monovalent cation:proton antiporter activity
NW313_RS16360	COG2212	antiporter activity
NW313_RS16365	COG1863	multisubunit Na H antiporter MnhE subunit
NW313_RS16370	COG0651	ATP synthesis coupled electron transport
NW313_RS16375	COG1006	Multisubunit Na H antiporter MnhC subunit
NW313_RS16380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NW313_RS16380	COG2111	Na H antiporter
NW313_RS16390	COG0589	response to stress
NW313_RS16395	COG0814	amino acid
NW313_RS16405	COG3530	Putative quorum-sensing-regulated virulence factor
NW313_RS16415	COG5002	protein histidine kinase activity
NW313_RS16415	COG5001	Diguanylate cyclase
NW313_RS16420	COG1278	Cold shock
NW313_RS16435	COG2304	oxidoreductase activity
NW313_RS16455	COG0714	Associated with various cellular activities
NW313_RS16460	COG0840	transmembrane signaling receptor activity
NW313_RS16475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NW313_RS16480	COG2195	Cleaves the N-terminal amino acid of tripeptides
NW313_RS16490	COG3604	Transcriptional regulator
NW313_RS16495	COG1017	nitric oxide dioxygenase activity
NW313_RS16495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NW313_RS16500	COG1278	Cold shock
NW313_RS16505	COG3036	rescue of stalled ribosome
NW313_RS16530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NW313_RS16530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NW313_RS16535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NW313_RS16545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NW313_RS16555	COG0516	GMP reductase activity
NW313_RS16580	COG3328	transposase activity
NW313_RS16595	COG0513	Belongs to the DEAD box helicase family
NW313_RS16600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NW313_RS16605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NW313_RS16610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NW313_RS16615	COG0784	Response regulator, receiver
NW313_RS16615	COG3437	response regulator, receiver
NW313_RS16620	COG4191	Histidine kinase
NW313_RS16620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NW313_RS16630	COG1757	Na H antiporter
NW313_RS16635	COG2814	Major facilitator Superfamily
NW313_RS16645	COG3706	GGDEF domain
NW313_RS16650	COG3240	lipase activity
NW313_RS16660	COG0840	transmembrane signaling receptor activity
NW313_RS16665	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NW313_RS16670	COG5380	lipid catabolic process
NW313_RS16695	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NW313_RS16700	COG4605	iron ion homeostasis
NW313_RS16705	COG4604	ABC transporter, ATP-binding protein
NW313_RS16710	COG2207	Transcriptional regulator
NW313_RS16725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NW313_RS16745	COG0745	RESPONSE REGULATOR receiver
NW313_RS16755	COG3623	hexulose-6-phosphate isomerase
NW313_RS16760	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NW313_RS16765	COG0561	phosphatase activity
NW313_RS16795	COG3038	cytochrome b561
NW313_RS16800	COG0366	Alpha amylase catalytic
NW313_RS16825	COG0745	RESPONSE REGULATOR receiver
NW313_RS16830	COG5002	protein histidine kinase activity
NW313_RS16855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NW313_RS16870	COG2814	Major facilitator Superfamily
NW313_RS16885	COG1686	Belongs to the peptidase S11 family
NW313_RS16910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NW313_RS16910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NW313_RS16915	COG0509	glycine decarboxylation via glycine cleavage system
NW313_RS16920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NW313_RS16930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NW313_RS16940	COG3039	Transposase
NW313_RS16975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NW313_RS16980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NW313_RS17035	COG1028	Short-chain dehydrogenase reductase Sdr
NW313_RS17075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NW313_RS17100	COG0494	nUDIX hydrolase
NW313_RS17115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NW313_RS17120	COG3040	lipid binding
NW313_RS17150	COG3328	transposase activity
NW313_RS17155	COG3041	Addiction module toxin RelE StbE family
NW313_RS17270	COG1619	proteins homologs of microcin C7 resistance protein MccF
NW313_RS17280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NW313_RS17335	COG0346	lactoylglutathione lyase activity
NW313_RS17350	COG3040	lipid binding
NW313_RS17370	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NW313_RS17380	COG1280	lysine exporter protein (LysE YggA)
NW313_RS17565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NW313_RS17595	COG3549	Plasmid maintenance system killer
NW313_RS17600	COG3093	addiction module antidote protein HigA
NW313_RS17625	COG1619	proteins homologs of microcin C7 resistance protein MccF
NW313_RS17650	COG3040	lipid binding
NW313_RS17710	COG4977	sequence-specific DNA binding
NW313_RS17790	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
NW313_RS17795	COG2944	sequence-specific DNA binding
NW313_RS17810	COG3039	Transposase
NW313_RS17840	COG0346	lactoylglutathione lyase activity
NW313_RS18005	COG0346	lactoylglutathione lyase activity
NW313_RS18020	COG1328	CTP reductase activity
NW313_RS18025	COG0602	queuosine metabolic process
NW313_RS18035	COG0189	ligase activity
NW313_RS18035	COG4067	protein conserved in archaea
NW313_RS18040	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NW313_RS18040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NW313_RS18040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NW313_RS18045	COG1105	Belongs to the carbohydrate kinase PfkB family
NW313_RS18050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW313_RS18050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NW313_RS18055	COG1609	Transcriptional regulator
NW313_RS18060	COG0420	3'-5' exonuclease activity
NW313_RS18065	COG0419	ATPase involved in DNA repair
NW313_RS18070	COG2205	protein histidine kinase activity
NW313_RS18070	COG0784	Response regulator, receiver
NW313_RS18075	COG0156	8-amino-7-oxononanoate synthase activity
NW313_RS18090	COG0523	cobalamin synthesis protein
NW313_RS18105	COG0674	pyruvate-flavodoxin oxidoreductase activity
NW313_RS18105	COG1013	pyruvate-flavodoxin oxidoreductase activity
NW313_RS18105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NW313_RS18105	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NW313_RS18110	COG2205	protein histidine kinase activity
NW313_RS18115	COG0745	RESPONSE REGULATOR receiver
NW313_RS18120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NW313_RS18125	COG0586	Pfam SNARE associated Golgi protein
NW313_RS18135	COG2200	EAL domain
NW313_RS18145	COG3038	cytochrome b561
NW313_RS18155	COG2116	formate transmembrane transporter activity
NW313_RS18160	COG0583	DNA-binding transcription factor activity
NW313_RS18170	COG3593	DNA synthesis involved in DNA repair
NW313_RS18175	COG0737	Belongs to the 5'-nucleotidase family
NW313_RS18190	COG2824	Alkylphosphonate utilization operon protein PhnA
NW313_RS18220	COG2199	diguanylate cyclase activity
NW313_RS18240	COG3706	GGDEF domain
NW313_RS18255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NW313_RS18260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NW313_RS18270	COG0745	RESPONSE REGULATOR receiver
NW313_RS18285	COG3140	Belongs to the UPF0181 family
NW313_RS18290	COG0023	Translation Initiation Factor
NW313_RS18310	COG0045	succinate-CoA ligase (ADP-forming) activity
NW313_RS18310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NW313_RS18310	COG1042	CoA-binding domain protein
NW313_RS18315	COG0583	DNA-binding transcription factor activity
NW313_RS18320	COG1629	transport
NW313_RS18320	COG4771	TonB-dependent receptor
NW313_RS18335	COG2050	protein possibly involved in aromatic compounds catabolism
NW313_RS18355	COG0625	glutathione transferase activity
NW313_RS18370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NW313_RS18375	COG4172	Belongs to the ABC transporter superfamily
NW313_RS18380	COG4239	(ABC) transporter, permease
NW313_RS18385	COG4174	ABC transporter (Permease)
NW313_RS18390	COG4166	transmembrane transport
NW313_RS18415	COG3104	oligopeptide transport
NW313_RS18435	COG3842	ATPase activity
NW313_RS18445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NW313_RS18450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NW313_RS18455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NW313_RS18460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NW313_RS18465	COG1011	Hydrolase
NW313_RS18475	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NW313_RS18480	COG1970	mechanosensitive ion channel activity
NW313_RS18485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NW313_RS18490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NW313_RS18490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NW313_RS18495	COG0302	gtp cyclohydrolase
NW313_RS18505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NW313_RS18515	COG2897	thiosulfate sulfurtransferase activity
NW313_RS18520	COG2390	Transcriptional regulator
NW313_RS18530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NW313_RS18555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NW313_RS18580	COG0583	DNA-binding transcription factor activity
NW313_RS18585	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NW313_RS18625	COG0446	pyridine nucleotide-disulphide oxidoreductase
NW313_RS18670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NW313_RS18670	COG1263	PTS System
NW313_RS18675	COG1609	Transcriptional regulator
NW313_RS18680	COG1621	beta-fructofuranosidase activity
NW313_RS18685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NW313_RS18690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NW313_RS18700	COG2885	chlorophyll binding
NW313_RS18705	COG0545	Peptidyl-prolyl cis-trans isomerase
NW313_RS18710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NW313_RS18715	COG0840	transmembrane signaling receptor activity
NW313_RS18720	COG3069	C4-dicarboxylate transmembrane transporter activity
NW313_RS18725	COG1760	l-serine dehydratase
NW313_RS18745	COG1609	Transcriptional regulator
NW313_RS18750	COG2197	response regulator
NW313_RS18755	COG3850	Histidine kinase
NW313_RS18760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NW313_RS18770	COG0243	molybdopterin cofactor binding
NW313_RS18790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NW313_RS18795	COG2197	response regulator
NW313_RS18800	COG3851	Histidine kinase
NW313_RS18805	COG2271	Major facilitator Superfamily
NW313_RS18810	COG1840	ABC-type Fe3 transport system, periplasmic component
NW313_RS18820	COG3842	ATPase activity
NW313_RS18825	COG3243	poly(R)-hydroxyalkanoic acid synthase
NW313_RS18835	COG0183	Belongs to the thiolase family
NW313_RS18845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NW313_RS18850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NW313_RS18870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NW313_RS18880	COG1979	alcohol dehydrogenase
NW313_RS18895	COG4191	Histidine kinase
NW313_RS18905	COG2271	Major facilitator Superfamily
NW313_RS18910	COG0469	pyruvate kinase activity
NW313_RS18915	COG0784	Response regulator, receiver
NW313_RS18915	COG2198	Histidine kinase
NW313_RS18915	COG2205	protein histidine kinase activity
NW313_RS18920	COG1879	ABC-type sugar transport system periplasmic component
NW313_RS18925	COG1803	Methylglyoxal synthase
NW313_RS18930	COG1335	isochorismatase
NW313_RS18935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NW313_RS18950	COG0210	DNA helicase
NW313_RS18955	COG1289	transmembrane transporter activity