locus-tag	class	description
N16961_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N16961_RS00010	COG0592	DNA-directed DNA polymerase activity
N16961_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N16961_RS00020	COG0187	DNA topoisomerase II activity
N16961_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
N16961_RS00040	COG3977	Valine--pyruvate aminotransferase
N16961_RS00050	COG0751	glycine-tRNA ligase activity
N16961_RS00055	COG0752	glycyl-tRNA synthetase alpha subunit
N16961_RS00060	COG2119	membrane
N16961_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
N16961_RS00085	COG0604	alcohol dehydrogenase
N16961_RS00095	COG0129	dihydroxy-acid dehydratase activity
N16961_RS00100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N16961_RS00115	COG0606	chelatase, subunit chli
N16961_RS00120	COG0204	Acyl-transferase
N16961_RS00125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N16961_RS00130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N16961_RS00145	COG3084	Protein conserved in bacteria
N16961_RS00155	COG4326	sporulation control protein
N16961_RS00160	COG1272	protein, Hemolysin III
N16961_RS00170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N16961_RS00175	COG0569	domain protein
N16961_RS00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N16961_RS00180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N16961_RS00185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N16961_RS00190	COG0242	peptide deformylase activity
N16961_RS00195	COG1652	LysM domain
N16961_RS00200	COG0758	DNA mediated transformation
N16961_RS00205	COG2922	Belongs to the Smg family
N16961_RS00210	COG0551	DNA topoisomerase type I activity
N16961_RS00215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N16961_RS00220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N16961_RS00225	COG0009	L-threonylcarbamoyladenylate synthase
N16961_RS00230	COG0408	coproporphyrinogen oxidase activity
N16961_RS00235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N16961_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N16961_RS00285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N16961_RS00290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N16961_RS00300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N16961_RS00305	COG2104	thiamine diphosphate biosynthetic process
N16961_RS00310	COG2022	thiamine diphosphate biosynthetic process
N16961_RS00315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N16961_RS00320	COG0006	proline dipeptidase activity
N16961_RS00320	COG0006	proline dipeptidase activity
N16961_RS00340	COG1522	sequence-specific DNA binding
N16961_RS00345	COG5001	Diguanylate cyclase
N16961_RS00345	COG5002	protein histidine kinase activity
N16961_RS00365	COG0589	response to stress
N16961_RS00375	COG1528	Iron-storage protein
N16961_RS00385	COG2081	HI0933 family
N16961_RS00395	COG1322	Protein conserved in bacteria
N16961_RS00400	COG2226	methyltransferase
N16961_RS00415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N16961_RS00420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N16961_RS00425	COG0805	protein transport
N16961_RS00430	COG1858	cytochrome C peroxidase
N16961_RS00435	COG0534	Mate efflux family protein
N16961_RS00445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N16961_RS00460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N16961_RS00465	COG3161	chorismate lyase activity
N16961_RS00475	COG1580	Controls the rotational direction of flagella during chemotaxis
N16961_RS00480	COG0840	transmembrane signaling receptor activity
N16961_RS00490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N16961_RS00500	COG0084	hydrolase, TatD family'
N16961_RS00515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N16961_RS00515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N16961_RS00535	COG3078	GTPase activator activity
N16961_RS00550	COG3071	HemY protein
N16961_RS00555	COG2959	enzyme of heme biosynthesis
N16961_RS00560	COG1587	Uroporphyrinogen-III synthase
N16961_RS00565	COG0181	hydroxymethylbilane synthase activity
N16961_RS00580	COG1965	Belongs to the frataxin family
N16961_RS00590	COG0019	diaminopimelate decarboxylase activity
N16961_RS00595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N16961_RS00605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N16961_RS00610	COG1011	Hydrolase
N16961_RS00615	COG2199	diguanylate cyclase activity
N16961_RS00615	COG2200	EAL domain
N16961_RS00615	COG3287	FIST C domain
N16961_RS00635	COG0561	phosphatase activity
N16961_RS00640	COG2267	carboxylic ester hydrolase activity
N16961_RS00645	COG1280	lysine exporter protein (LysE YggA)
N16961_RS00650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N16961_RS00655	COG0783	Belongs to the Dps family
N16961_RS00695	COG0742	ribosomal rna small subunit methyltransferase
N16961_RS00700	COG0552	protein localization to endoplasmic reticulum
N16961_RS00705	COG2884	Cell division ATP-binding protein ftsE
N16961_RS00710	COG2177	Part of the ABC transporter FtsEX involved in
N16961_RS00715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N16961_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_RS00740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N16961_RS00745	COG4206	TonB-dependent receptor
N16961_RS00750	COG1404	Belongs to the peptidase S8 family
N16961_RS00755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N16961_RS00825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N16961_RS00830	COG5001	Diguanylate cyclase
N16961_RS00830	COG3300	MHYT domain
N16961_RS00840	COG3852	Histidine kinase
N16961_RS00850	COG0174	glutamine synthetase
N16961_RS00860	COG1217	gtp-binding protein TYPA
N16961_RS00865	COG1660	Displays ATPase and GTPase activities
N16961_RS00870	COG1295	ribonuclease BN
N16961_RS00875	COG1490	D-aminoacyl-tRNA deacylase activity
N16961_RS00880	COG0456	acetyltransferase
N16961_RS00890	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N16961_RS00895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N16961_RS00900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N16961_RS00905	COG3031	protein transport across the cell outer membrane
N16961_RS00915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_RS00920	COG1459	type II secretion system
N16961_RS00925	COG2165	general secretion pathway protein
N16961_RS00930	COG2165	general secretion pathway protein
N16961_RS00935	COG2165	general secretion pathway protein
N16961_RS00940	COG4795	General secretion pathway protein
N16961_RS00945	COG3156	type II secretion system protein K
N16961_RS00950	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N16961_RS00955	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N16961_RS00965	COG1218	3'(2'),5'-bisphosphate nucleotidase
N16961_RS00970	COG0494	nUDIX hydrolase
N16961_RS00980	COG1040	competence protein
N16961_RS00985	COG0596	Alpha beta hydrolase
N16961_RS00995	COG2183	response to ionizing radiation
N16961_RS01000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N16961_RS01015	COG2233	PERMEase
N16961_RS01020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N16961_RS01025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N16961_RS01030	COG1758	RNA polymerase activity
N16961_RS01035	COG0194	GDP metabolic process
N16961_RS01040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N16961_RS01045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N16961_RS01065	COG4232	protein-disulfide reductase activity
N16961_RS01075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N16961_RS01080	COG1027	Aspartate ammonia-lyase
N16961_RS01085	COG3706	GGDEF domain
N16961_RS01090	COG3030	protein affecting phage T7 exclusion by the F plasmid
N16961_RS01095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N16961_RS01105	COG2205	protein histidine kinase activity
N16961_RS01110	COG0745	RESPONSE REGULATOR receiver
N16961_RS01120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N16961_RS01125	COG0205	6-phosphofructokinase activity
N16961_RS01130	COG1494	fructose-1,6-bisphosphatase
N16961_RS01135	COG3074	FtsZ-dependent cytokinesis
N16961_RS01140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N16961_RS01145	COG0460	homoserine dehydrogenase
N16961_RS01145	COG0527	aspartate kinase activity
N16961_RS01150	COG0626	cystathionine gamma-synthase activity
N16961_RS01155	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
N16961_RS01160	COG0281	malic enzyme
N16961_RS01165	COG0254	rRNA binding
N16961_RS01170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N16961_RS01175	COG1609	Transcriptional regulator
N16961_RS01180	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N16961_RS01185	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N16961_RS01190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N16961_RS01195	COG1575	Belongs to the MenA family. Type 1 subfamily
N16961_RS01200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N16961_RS01205	COG0534	Mate efflux family protein
N16961_RS01210	COG0149	triose-phosphate isomerase activity
N16961_RS01240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N16961_RS01245	COG0459	protein refolding
N16961_RS01255	COG1509	lysine 2,3-aminomutase activity
N16961_RS01260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N16961_RS01270	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N16961_RS01275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N16961_RS01280	COG1053	succinate dehydrogenase
N16961_RS01285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N16961_RS01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N16961_RS01295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N16961_RS01300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N16961_RS01305	COG1045	serine acetyltransferase
N16961_RS01315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N16961_RS01320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N16961_RS01325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N16961_RS01330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N16961_RS01335	COG0137	argininosuccinate synthase activity
N16961_RS01345	COG0165	Argininosuccinate lyase
N16961_RS01355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_RS01360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N16961_RS01360	COG0678	peroxiredoxin activity
N16961_RS01370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N16961_RS01400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N16961_RS01405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N16961_RS01415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N16961_RS01420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N16961_RS01425	COG0546	phosphoglycolate phosphatase activity
N16961_RS01430	COG0180	Tryptophanyl-tRNA synthetase
N16961_RS01445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N16961_RS01455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N16961_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
N16961_RS01480	COG3954	Phosphoribulokinase
N16961_RS01490	COG0429	hydrolase of the alpha beta-hydrolase fold
N16961_RS01500	COG0488	(ABC) transporter
N16961_RS01505	COG2249	NAD(P)H dehydrogenase (quinone) activity
N16961_RS01520	COG1047	Peptidyl-prolyl cis-trans
N16961_RS01540	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N16961_RS01545	COG3083	sulfuric ester hydrolase activity
N16961_RS01550	COG0557	exoribonuclease II activity
N16961_RS01555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N16961_RS01560	COG0051	transcription antitermination factor activity, RNA binding
N16961_RS01565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N16961_RS01570	COG0088	Forms part of the polypeptide exit tunnel
N16961_RS01575	COG0089	rRNA binding
N16961_RS01580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N16961_RS01585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N16961_RS01590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N16961_RS01595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N16961_RS01600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N16961_RS01605	COG0255	Belongs to the universal ribosomal protein uL29 family
N16961_RS01610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N16961_RS01615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N16961_RS01620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N16961_RS01625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N16961_RS01630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N16961_RS01635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N16961_RS01645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N16961_RS01650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N16961_RS01655	COG1841	ribosomal large subunit assembly
N16961_RS01665	COG0201	protein transport
N16961_RS01670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N16961_RS01675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N16961_RS01680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N16961_RS01685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N16961_RS01690	COG0202	RNA polymerase activity
N16961_RS01695	COG0203	ribosomal protein L17
N16961_RS01705	COG0545	Peptidyl-prolyl cis-trans isomerase
N16961_RS01710	COG3266	domain, Protein
N16961_RS01710	COG3061	Opacity-associated protein A
N16961_RS01715	COG0697	spore germination
N16961_RS01720	COG2153	protein acetylation
N16961_RS01725	COG0513	Belongs to the DEAD box helicase family
N16961_RS01735	COG0737	Belongs to the 5'-nucleotidase family
N16961_RS01740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N16961_RS01740	COG1648	precorrin-2 dehydrogenase activity
N16961_RS01755	COG0529	Catalyzes the synthesis of activated sulfate
N16961_RS01775	COG1136	(ABC) transporter
N16961_RS01790	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N16961_RS01795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_RS01800	COG0729	surface antigen
N16961_RS01810	COG2105	PFAM AIG2 family protein
N16961_RS01815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N16961_RS01830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N16961_RS01835	COG0163	prenyltransferase activity
N16961_RS01845	COG1178	ABC-type Fe3 transport system permease component
N16961_RS01850	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N16961_RS01855	COG3028	Belongs to the UPF0307 family
N16961_RS01860	COG0312	modulator of DNA gyrase
N16961_RS01865	COG2239	Acts as a magnesium transporter
N16961_RS01870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_RS01875	COG1660	Displays ATPase and GTPase activities
N16961_RS01880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_RS01885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N16961_RS01895	COG1137	ATPase activity
N16961_RS01900	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N16961_RS01915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N16961_RS01915	COG0517	IMP dehydrogenase activity
N16961_RS01930	COG1127	ABC transporter
N16961_RS01935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N16961_RS01940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N16961_RS01945	COG2854	intermembrane phospholipid transfer
N16961_RS01955	COG5007	Belongs to the BolA IbaG family
N16961_RS01960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N16961_RS01970	COG0251	oxidation-reduction process
N16961_RS01980	COG0540	Belongs to the ATCase OTCase family
N16961_RS01990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N16961_RS02005	COG0564	pseudouridine synthase activity
N16961_RS02010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N16961_RS02015	COG0525	valine-tRNA ligase activity
N16961_RS02020	COG2927	DNA polymerase III (CHI subunit)
N16961_RS02025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N16961_RS02030	COG0795	lipopolysaccharide-transporting ATPase activity
N16961_RS02035	COG0795	lipopolysaccharide-transporting ATPase activity
N16961_RS02050	COG3437	response regulator, receiver
N16961_RS02095	COG0066	3-isopropylmalate dehydratase activity
N16961_RS02100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N16961_RS02105	COG0473	3-isopropylmalate dehydrogenase activity
N16961_RS02130	COG0583	DNA-binding transcription factor activity
N16961_RS02135	COG1022	Amp-dependent synthetase and ligase
N16961_RS02140	COG0028	Belongs to the TPP enzyme family
N16961_RS02145	COG0440	acetolactate synthase activity
N16961_RS02150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N16961_RS02155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N16961_RS02160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N16961_RS02170	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N16961_RS02175	COG3079	Belongs to the UPF0149 family
N16961_RS02180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_RS02185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_RS02200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N16961_RS02210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N16961_RS02220	COG1595	DNA-templated transcription, initiation
N16961_RS02235	COG3086	response to oxidative stress
N16961_RS02240	COG0481	GTPase activity
N16961_RS02255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N16961_RS02260	COG1381	Involved in DNA repair and RecF pathway recombination
N16961_RS02265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N16961_RS02285	COG5001	Diguanylate cyclase
N16961_RS02300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N16961_RS02305	COG3956	TIGRFAM MazG family protein
N16961_RS02310	COG0504	CTP synthase activity
N16961_RS02315	COG0148	phosphopyruvate hydratase activity
N16961_RS02325	COG3409	Peptidoglycan-binding domain 1 protein
N16961_RS02325	COG3267	Type II secretory pathway component ExeA
N16961_RS02335	COG4991	sh3 domain protein
N16961_RS02340	COG0306	phosphate transporter
N16961_RS02345	COG1392	Phosphate transport regulator
N16961_RS02350	COG3025	triphosphatase activity
N16961_RS02355	COG0840	transmembrane signaling receptor activity
N16961_RS02360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N16961_RS02370	COG1538	Outer membrane efflux protein
N16961_RS02375	COG0494	nUDIX hydrolase
N16961_RS02380	COG3151	Protein conserved in bacteria
N16961_RS02390	COG3150	esterase
N16961_RS02395	COG0187	DNA topoisomerase II activity
N16961_RS02400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N16961_RS02410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
N16961_RS02415	COG0237	dephospho-CoA kinase activity
N16961_RS02425	COG1459	type II secretion system
N16961_RS02430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_RS02450	COG0716	FMN binding
N16961_RS02455	COG4974	Belongs to the 'phage' integrase family
N16961_RS02460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N16961_RS02465	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N16961_RS02470	COG0737	Belongs to the 5'-nucleotidase family
N16961_RS02480	COG2186	Transcriptional regulator
N16961_RS02485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N16961_RS02490	COG0508	dehydrogenase complex catalyzes the overall conversion of
N16961_RS02495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_RS02510	COG3116	cell division
N16961_RS02515	COG0768	penicillin binding
N16961_RS02520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N16961_RS02525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N16961_RS02535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N16961_RS02540	COG0772	Belongs to the SEDS family
N16961_RS02550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N16961_RS02555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N16961_RS02560	COG0849	cell division
N16961_RS02565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N16961_RS02570	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N16961_RS02580	COG0653	protein targeting
N16961_RS02585	COG0494	nUDIX hydrolase
N16961_RS02590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N16961_RS02600	COG0505	Belongs to the CarA family
N16961_RS02605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N16961_RS02625	COG4172	Belongs to the ABC transporter superfamily
N16961_RS02635	COG0730	response to heat
N16961_RS02640	COG0583	DNA-binding transcription factor activity
N16961_RS02645	COG2860	membrane
N16961_RS02650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N16961_RS02660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N16961_RS02670	COG0493	'glutamate synthase
N16961_RS02675	COG0067	glutamate synthase
N16961_RS02675	COG0070	glutamate synthase
N16961_RS02675	COG0069	glutamate synthase activity
N16961_RS02685	COG0070	glutamate synthase
N16961_RS02685	COG0067	glutamate synthase
N16961_RS02685	COG0069	glutamate synthase activity
N16961_RS02690	COG1242	4 iron, 4 sulfur cluster binding
N16961_RS02695	COG3706	GGDEF domain
N16961_RS02695	COG5001	Diguanylate cyclase
N16961_RS02695	COG2203	Gaf domain
N16961_RS02695	COG4251	negative regulation of phosphorylation
N16961_RS02700	COG5002	protein histidine kinase activity
N16961_RS02700	COG2198	Histidine kinase
N16961_RS02700	COG0784	Response regulator, receiver
N16961_RS02705	COG0745	RESPONSE REGULATOR receiver
N16961_RS02715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N16961_RS02740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N16961_RS02745	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
N16961_RS02750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N16961_RS02755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N16961_RS02770	COG1115	amino acid carrier protein
N16961_RS02775	COG3022	response to hydroperoxide
N16961_RS02780	COG0084	hydrolase, TatD family'
N16961_RS02785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N16961_RS02795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N16961_RS02800	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N16961_RS02805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N16961_RS02810	COG0813	purine-nucleoside phosphorylase activity
N16961_RS02820	COG0560	Phosphoserine phosphatase
N16961_RS02835	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N16961_RS02840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N16961_RS02845	COG1022	Amp-dependent synthetase and ligase
N16961_RS02860	COG3250	beta-galactosidase activity
N16961_RS02865	COG1609	Transcriptional regulator
N16961_RS02870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_RS02885	COG0569	domain protein
N16961_RS02885	COG0189	ligase activity
N16961_RS02890	COG0456	acetyltransferase
N16961_RS02900	COG2171	N-acyltransferase activity
N16961_RS02905	COG3141	response to X-ray
N16961_RS02920	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N16961_RS02925	COG1074	ATP-dependent DNA helicase activity
N16961_RS02930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N16961_RS02940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N16961_RS02940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N16961_RS02950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N16961_RS02955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N16961_RS02960	COG2166	iron-sulfur cluster assembly
N16961_RS02965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N16961_RS02970	COG0693	protein deglycase activity
N16961_RS02975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N16961_RS02980	COG3248	Nucleoside-binding outer membrane protein
N16961_RS02990	COG1595	DNA-templated transcription, initiation
N16961_RS03000	COG2211	Major facilitator Superfamily
N16961_RS03010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N16961_RS03020	COG2813	Specifically methylates the guanine in position
N16961_RS03025	COG0271	Belongs to the BolA IbaG family
N16961_RS03030	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_RS03035	COG1805	sodium ion transport
N16961_RS03040	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_RS03045	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_RS03050	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N16961_RS03055	COG2871	sodium ion transport
N16961_RS03060	COG1477	protein flavinylation
N16961_RS03080	COG3706	GGDEF domain
N16961_RS03085	COG0733	neurotransmitter:sodium symporter activity
N16961_RS03095	COG0189	ligase activity
N16961_RS03100	COG0189	ligase activity
N16961_RS03100	COG4067	protein conserved in archaea
N16961_RS03105	COG2195	Cleaves the N-terminal amino acid of tripeptides
N16961_RS03110	COG2252	PERMEase
N16961_RS03115	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N16961_RS03120	COG1073	alpha beta
N16961_RS03130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N16961_RS03135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N16961_RS03140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N16961_RS03145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N16961_RS03145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N16961_RS03160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N16961_RS03165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N16961_RS03170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N16961_RS03175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N16961_RS03190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N16961_RS03195	COG0024	Methionine aminopeptidase
N16961_RS03200	COG0052	Belongs to the universal ribosomal protein uS2 family
N16961_RS03205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N16961_RS03210	COG0528	UMP kinase activity
N16961_RS03215	COG0233	cytoplasmic translational termination
N16961_RS03220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N16961_RS03225	COG0575	Belongs to the CDS family
N16961_RS03230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N16961_RS03235	COG0750	zinc metalloprotease
N16961_RS03245	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N16961_RS03250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_RS03255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N16961_RS03260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_RS03265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_RS03270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N16961_RS03275	COG0587	DNA-directed DNA polymerase activity
N16961_RS03280	COG0825	malonyl-CoA metabolic process
N16961_RS03285	COG0037	tRNA processing
N16961_RS03295	COG3479	Phenolic acid decarboxylase
N16961_RS03300	COG0347	Belongs to the P(II) protein family
N16961_RS03305	COG3021	interspecies interaction between organisms
N16961_RS03310	COG0741	lytic transglycosylase activity
N16961_RS03310	COG1388	LysM domain
N16961_RS03315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N16961_RS03320	COG2226	methyltransferase
N16961_RS03325	COG0328	RNA-DNA hybrid ribonuclease activity
N16961_RS03340	COG1960	acyl-CoA dehydrogenase activity
N16961_RS03345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N16961_RS03350	COG0121	glutamine amidotransferase
N16961_RS03355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N16961_RS03360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N16961_RS03365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N16961_RS03375	COG1187	pseudouridine synthase activity
N16961_RS03380	COG2840	Smr protein MutS2
N16961_RS03395	COG3735	TraB family
N16961_RS03410	COG2217	Heavy metal translocating P-type atpase
N16961_RS03410	COG2608	mercury ion transmembrane transporter activity
N16961_RS03415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N16961_RS03430	COG1629	transport
N16961_RS03430	COG4774	siderophore transport
N16961_RS03435	COG2375	cellular response to nickel ion
N16961_RS03440	COG3433	isochorismatase activity
N16961_RS03440	COG2226	methyltransferase
N16961_RS03440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N16961_RS03475	COG0835	chemotaxis
N16961_RS03475	COG0784	Response regulator, receiver
N16961_RS03480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N16961_RS03485	COG1815	bacterial-type flagellum-dependent cell motility
N16961_RS03500	COG1749	Flagellar hook protein flgE
N16961_RS03505	COG4787	bacterial-type flagellum-dependent cell motility
N16961_RS03515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N16961_RS03520	COG1706	bacterial-type flagellum-dependent cell motility
N16961_RS03525	COG1705	Flagellar rod assembly protein muramidase FlgJ
N16961_RS03525	COG3951	Flagellar rod assembly protein muramidase FlgJ
N16961_RS03540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_RS03545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_RS03630	COG0012	GTP binding
N16961_RS03635	COG0193	aminoacyl-tRNA hydrolase activity
N16961_RS03640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N16961_RS03650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N16961_RS03655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N16961_RS03660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N16961_RS03665	COG2890	protein-(glutamine-N5) methyltransferase activity
N16961_RS03675	COG2912	Transglutaminase-like superfamily
N16961_RS03680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N16961_RS03685	COG0737	Belongs to the 5'-nucleotidase family
N16961_RS03690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N16961_RS03695	COG2233	PERMEase
N16961_RS03715	COG1393	Belongs to the ArsC family
N16961_RS03720	COG4783	chaperone-mediated protein folding
N16961_RS03735	COG0840	transmembrane signaling receptor activity
N16961_RS03740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N16961_RS03755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
N16961_RS03765	COG1876	peptidase activity
N16961_RS03775	COG1393	Belongs to the ArsC family
N16961_RS03795	COG2837	iron assimilation
N16961_RS03800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_RS03805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_RS03810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N16961_RS03815	COG1334	flagellar protein FlaG
N16961_RS03820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N16961_RS03830	COG1516	flagellar protein fliS
N16961_RS03850	COG1677	Flagellar hook-basal body complex protein FliE
N16961_RS03860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N16961_RS03865	COG1317	bacterial-type flagellum organization
N16961_RS03890	COG1580	Controls the rotational direction of flagella during chemotaxis
N16961_RS03915	COG1987	bacterial-type flagellum assembly
N16961_RS03920	COG1684	flagellar biosynthetic protein fliR
N16961_RS03930	COG2840	Smr protein MutS2
N16961_RS03935	COG2890	protein-(glutamine-N5) methyltransferase activity
N16961_RS03945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N16961_RS03950	COG2860	membrane
N16961_RS03955	COG3101	peptidyl-lysine hydroxylation
N16961_RS03965	COG0431	NADPH-dependent FMN reductase
N16961_RS03975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N16961_RS03980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N16961_RS03985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N16961_RS03990	COG0735	belongs to the Fur family
N16961_RS04000	COG0583	DNA-binding transcription factor activity
N16961_RS04010	COG1346	cytolysis
N16961_RS04025	COG0596	Alpha beta hydrolase
N16961_RS04030	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N16961_RS04035	COG0033	Phosphoglucomutase
N16961_RS04045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N16961_RS04050	COG0372	Belongs to the citrate synthase family
N16961_RS04055	COG2009	succinate dehydrogenase
N16961_RS04060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N16961_RS04065	COG1053	succinate dehydrogenase
N16961_RS04075	COG0567	Dehydrogenase, E1 component
N16961_RS04080	COG0508	dehydrogenase complex catalyzes the overall conversion of
N16961_RS04085	COG0045	succinate-CoA ligase (ADP-forming) activity
N16961_RS04095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N16961_RS04100	COG1121	(ABC) transporter
N16961_RS04105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N16961_RS04110	COG4977	sequence-specific DNA binding
N16961_RS04115	COG1918	ferrous iron import across plasma membrane
N16961_RS04135	COG0018	arginyl-trna synthetase
N16961_RS04145	COG1025	Belongs to the peptidase M16 family
N16961_RS04150	COG2062	phosphohistidine phosphatase, SixA
N16961_RS04180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N16961_RS04185	COG0784	Response regulator, receiver
N16961_RS04185	COG2198	Histidine kinase
N16961_RS04185	COG0643	Histidine kinase
N16961_RS04190	COG2201	protein-glutamate methylesterase activity
N16961_RS04195	COG1192	Involved in chromosome partitioning
N16961_RS04205	COG0835	chemotaxis
N16961_RS04215	COG4133	protoheme IX ABC transporter activity
N16961_RS04220	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N16961_RS04225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N16961_RS04235	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N16961_RS04240	COG1138	Cytochrome C-type biogenesis protein
N16961_RS04245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N16961_RS04250	COG3088	subunit of a heme lyase
N16961_RS04250	COG4235	cytochrome complex assembly
N16961_RS04260	COG2853	Lipoprotein
N16961_RS04280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N16961_RS04285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N16961_RS04290	COG0123	including yeast histone deacetylase and acetoin utilization protein
N16961_RS04305	COG3083	sulfuric ester hydrolase activity
N16961_RS04310	COG3082	Protein of unknown function (DUF1414)
N16961_RS04315	COG3081	Nucleoid-associated protein
N16961_RS04325	COG1757	Na H antiporter
N16961_RS04330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N16961_RS04335	COG2095	MarC family integral membrane protein
N16961_RS04340	COG1012	belongs to the aldehyde dehydrogenase family
N16961_RS04340	COG1454	alcohol dehydrogenase
N16961_RS04355	COG0659	secondary active sulfate transmembrane transporter activity
N16961_RS04360	COG1530	ribonuclease E activity
N16961_RS04375	COG0564	pseudouridine synthase activity
N16961_RS04380	COG0424	maF-like protein
N16961_RS04385	COG1399	metal-binding, possibly nucleic acid-binding protein
N16961_RS04390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N16961_RS04395	COG0416	fatty acid biosynthetic process
N16961_RS04400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N16961_RS04410	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_RS04415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N16961_RS04420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N16961_RS04425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N16961_RS04430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N16961_RS04435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N16961_RS04445	COG0084	hydrolase, TatD family'
N16961_RS04450	COG1263	PTS System
N16961_RS04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_RS04460	COG0733	neurotransmitter:sodium symporter activity
N16961_RS04475	COG4667	esterase of the alpha-beta hydrolase superfamily
N16961_RS04485	COG1940	carbohydrate kinase activity
N16961_RS04490	COG0784	Response regulator, receiver
N16961_RS04490	COG0835	chemotaxis
N16961_RS04505	COG2226	methyltransferase
N16961_RS04525	COG0676	glucose-6-phosphate 1-epimerase activity
N16961_RS04530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N16961_RS04535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_RS04545	COG3139	Protein of unknown function (DUF1315)
N16961_RS04550	COG0252	asparaginase activity
N16961_RS04555	COG0616	signal peptide processing
N16961_RS04560	COG1902	pentaerythritol trinitrate reductase activity
N16961_RS04560	COG0446	pyridine nucleotide-disulphide oxidoreductase
N16961_RS04565	COG0788	formyltetrahydrofolate deformylase activity
N16961_RS04580	COG1199	ATP-dependent helicase activity
N16961_RS04585	COG1214	PFAM Peptidase M22, glycoprotease
N16961_RS04600	COG0596	Alpha beta hydrolase
N16961_RS04605	COG0318	PFAM AMP-dependent synthetase and ligase
N16961_RS04610	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N16961_RS04630	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N16961_RS04635	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N16961_RS04640	COG0436	Aminotransferase
N16961_RS04645	COG1169	isochorismate synthase
N16961_RS04650	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N16961_RS04655	COG0596	Alpha beta hydrolase
N16961_RS04675	COG3135	benzoate transporter
N16961_RS04680	COG1396	sequence-specific DNA binding
N16961_RS04685	COG0840	transmembrane signaling receptor activity
N16961_RS04690	COG0477	Major facilitator Superfamily
N16961_RS04710	COG3015	lipoprotein NlpE involved in copper resistance
N16961_RS04715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N16961_RS04720	COG2894	cell division
N16961_RS04725	COG0850	regulation of cytokinetic process
N16961_RS04730	COG3100	YcgL domain-containing protein
N16961_RS04735	COG2951	lytic endotransglycosylase activity
N16961_RS04745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N16961_RS04750	COG3469	chitinase activity
N16961_RS04750	COG3325	Belongs to the glycosyl hydrolase 18 family
N16961_RS04755	COG3005	denitrification pathway
N16961_RS04760	COG0243	molybdopterin cofactor binding
N16961_RS04780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_RS04790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N16961_RS04830	COG4589	Belongs to the CDS family
N16961_RS04840	COG5001	Diguanylate cyclase
N16961_RS04840	COG3300	MHYT domain
N16961_RS04855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N16961_RS04860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N16961_RS04865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N16961_RS04870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N16961_RS04880	COG4191	Histidine kinase
N16961_RS04890	COG0544	peptidyl-prolyl cis-trans isomerase activity
N16961_RS04900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N16961_RS04905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N16961_RS04910	COG0776	regulation of translation
N16961_RS04915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N16961_RS04920	COG1555	photosystem II stabilization
N16961_RS04925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N16961_RS04930	COG0539	negative regulation of cytoplasmic translation
N16961_RS04935	COG0776	regulation of translation
N16961_RS04940	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N16961_RS04945	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N16961_RS04965	COG0583	DNA-binding transcription factor activity
N16961_RS04975	COG0686	Belongs to the AlaDH PNT family
N16961_RS04985	COG1674	ftsk spoiiie
N16961_RS04990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N16961_RS04995	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N16961_RS05000	COG2186	Transcriptional regulator
N16961_RS05015	COG0537	adenosine 5'-monophosphoramidase activity
N16961_RS05040	COG3150	esterase
N16961_RS05045	COG1252	NADH dehydrogenase
N16961_RS05065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N16961_RS05075	COG4591	ABC-type transport system involved in lipoprotein release permease component
N16961_RS05080	COG1136	(ABC) transporter
N16961_RS05085	COG4591	ABC-type transport system involved in lipoprotein release permease component
N16961_RS05095	COG2333	competence protein COMEC
N16961_RS05095	COG0658	competence protein
N16961_RS05100	COG1132	(ABC) transporter
N16961_RS05105	COG1663	tetraacyldisaccharide 4'-kinase activity
N16961_RS05110	COG2835	tetraacyldisaccharide 4'-kinase activity
N16961_RS05115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N16961_RS05120	COG2719	SpoVR family
N16961_RS05125	COG2718	Belongs to the UPF0229 family
N16961_RS05130	COG2766	serine protein kinase
N16961_RS05135	COG3013	Belongs to the UPF0304 family
N16961_RS05145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N16961_RS05150	COG0840	transmembrane signaling receptor activity
N16961_RS05160	COG1882	Formate acetyltransferase
N16961_RS05190	COG4160	amino acid transport
N16961_RS05195	COG0708	Exodeoxyribonuclease III
N16961_RS05200	COG0840	transmembrane signaling receptor activity
N16961_RS05210	COG3923	Primosomal replication protein n
N16961_RS05215	COG0730	response to heat
N16961_RS05220	COG1199	ATP-dependent helicase activity
N16961_RS05225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N16961_RS05230	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N16961_RS05235	COG3012	SEC-C Motif Domain Protein
N16961_RS05240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N16961_RS05245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N16961_RS05250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N16961_RS05255	COG0215	cysteine-tRNA ligase activity
N16961_RS05260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N16961_RS05265	COG0632	four-way junction helicase activity
N16961_RS05275	COG1271	oxidase subunit
N16961_RS05280	COG1294	oxidase, subunit
N16961_RS05285	COG4890	Cyd operon protein YbgT
N16961_RS05290	COG3790	cyd operon protein YbgE
N16961_RS05295	COG0824	Thioesterase
N16961_RS05300	COG0811	peptide transport
N16961_RS05315	COG0823	Involved in the tonB-independent uptake of proteins
N16961_RS05320	COG2885	chlorophyll binding
N16961_RS05330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N16961_RS05340	COG0784	Response regulator, receiver
N16961_RS05340	COG5002	protein histidine kinase activity
N16961_RS05350	COG1482	cell wall glycoprotein biosynthetic process
N16961_RS05355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_RS05355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_RS05355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_RS05360	COG2207	Transcriptional regulator
N16961_RS05370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_RS05375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_RS05380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_RS05390	COG1012	belongs to the aldehyde dehydrogenase family
N16961_RS05395	COG3284	Transcriptional regulator
N16961_RS05400	COG4628	conserved protein (DUF2132)
N16961_RS05410	COG0415	Belongs to the DNA photolyase family
N16961_RS05490	COG0488	(ABC) transporter
N16961_RS05535	COG3941	tape measure
N16961_RS05550	COG2003	Belongs to the UPF0758 family
N16961_RS05560	COG4409	exo-alpha-(2->6)-sialidase activity
N16961_RS05565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N16961_RS05570	COG1940	carbohydrate kinase activity
N16961_RS05585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N16961_RS05590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N16961_RS05595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N16961_RS05600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N16961_RS05605	COG1737	Transcriptional regulator
N16961_RS05610	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
N16961_RS05615	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
N16961_RS05635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N16961_RS05655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N16961_RS05675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N16961_RS05680	COG0582	viral genome integration into host DNA
N16961_RS05685	COG0582	viral genome integration into host DNA
N16961_RS05700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_RS05710	COG3008	intermembrane lipid transfer
N16961_RS05710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N16961_RS05715	COG2995	paraquat-inducible protein a
N16961_RS05720	COG0668	transmembrane transport
N16961_RS05745	COG1309	transcriptional regulator
N16961_RS05750	COG1012	belongs to the aldehyde dehydrogenase family
N16961_RS05775	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N16961_RS05785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N16961_RS05815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N16961_RS05820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N16961_RS05825	COG0297	glycogen (starch) synthase activity
N16961_RS05845	COG3070	regulator of competence-specific genes
N16961_RS05850	COG1609	Transcriptional regulator
N16961_RS05860	COG3381	protein complex oligomerization
N16961_RS05865	COG0745	RESPONSE REGULATOR receiver
N16961_RS05870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N16961_RS05875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N16961_RS05885	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N16961_RS05905	COG1032	radical SAM domain protein
N16961_RS05910	COG5001	Diguanylate cyclase
N16961_RS05915	COG0612	Peptidase, M16
N16961_RS05930	COG0583	DNA-binding transcription factor activity
N16961_RS05935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N16961_RS05945	COG2350	Protein conserved in bacteria
N16961_RS05950	COG1607	acyl-coa hydrolase
N16961_RS05965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N16961_RS05970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N16961_RS05985	COG2116	formate transmembrane transporter activity
N16961_RS05995	COG4459	periplasmic nitrate reductase
N16961_RS06000	COG3005	denitrification pathway
N16961_RS06005	COG0243	molybdopterin cofactor binding
N16961_RS06030	COG1227	inorganic diphosphatase activity
N16961_RS06045	COG4172	Belongs to the ABC transporter superfamily
N16961_RS06060	COG4168	peptide transport system, permease
N16961_RS06070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N16961_RS06075	COG1842	Phage shock protein A
N16961_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_RS06105	COG2818	Glycosylase
N16961_RS06110	COG0626	cystathionine gamma-synthase activity
N16961_RS06125	COG0733	neurotransmitter:sodium symporter activity
N16961_RS06130	COG0564	pseudouridine synthase activity
N16961_RS06135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N16961_RS06140	COG4136	ATPase activity
N16961_RS06145	COG4135	transport system, permease component
N16961_RS06150	COG4134	Bacterial extracellular solute-binding protein
N16961_RS06160	COG3313	Fe-S protein
N16961_RS06170	COG0842	Transport permease protein
N16961_RS06175	COG1131	(ABC) transporter
N16961_RS06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_RS06185	COG0814	amino acid
N16961_RS06195	COG2239	Acts as a magnesium transporter
N16961_RS06200	COG0784	Response regulator, receiver
N16961_RS06200	COG2205	protein histidine kinase activity
N16961_RS06215	COG4934	collagen metabolic process
N16961_RS06245	COG0840	transmembrane signaling receptor activity
N16961_RS06260	COG2203	Gaf domain
N16961_RS06260	COG4251	negative regulation of phosphorylation
N16961_RS06260	COG5001	Diguanylate cyclase
N16961_RS06260	COG3706	GGDEF domain
N16961_RS06265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N16961_RS06285	COG1061	Type III restriction enzyme res subunit
N16961_RS06290	COG1187	pseudouridine synthase activity
N16961_RS06295	COG2814	Major facilitator Superfamily
N16961_RS06305	COG0702	epimerase
N16961_RS06310	COG0534	Mate efflux family protein
N16961_RS06315	COG4181	ATPase activity
N16961_RS06320	COG0577	efflux transmembrane transporter activity
N16961_RS06330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N16961_RS06345	COG1748	Saccharopine dehydrogenase
N16961_RS06360	COG1538	Outer membrane efflux protein
N16961_RS06380	COG0583	DNA-binding transcription factor activity
N16961_RS06390	COG1451	nucleotide metabolic process
N16961_RS06395	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
N16961_RS06405	COG3063	Type IV pilus biogenesis stability protein PilW
N16961_RS06410	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N16961_RS06430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_RS06445	COG3290	protein histidine kinase activity
N16961_RS06450	COG4565	transcriptional regulatory protein
N16961_RS06460	COG0835	chemotaxis
N16961_RS06460	COG0784	Response regulator, receiver
N16961_RS06505	COG1085	galactose-1-phosphate uridylyltransferase
N16961_RS06510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N16961_RS06515	COG2017	converts alpha-aldose to the beta-anomer
N16961_RS06525	COG2200	EAL domain
N16961_RS06525	COG2199	diguanylate cyclase activity
N16961_RS06540	COG3527	Alpha-acetolactate decarboxylase
N16961_RS06555	COG0753	catalase activity
N16961_RS06575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N16961_RS06585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N16961_RS06630	COG1271	oxidase subunit
N16961_RS06635	COG1294	oxidase, subunit
N16961_RS06640	COG1136	(ABC) transporter
N16961_RS06640	COG4591	ABC-type transport system involved in lipoprotein release permease component
N16961_RS06645	COG1136	(ABC) transporter
N16961_RS06645	COG0577	efflux transmembrane transporter activity
N16961_RS06650	COG0577	efflux transmembrane transporter activity
N16961_RS06650	COG1136	(ABC) transporter
N16961_RS06670	COG0583	DNA-binding transcription factor activity
N16961_RS06680	COG2723	6-phospho-beta-galactosidase activity
N16961_RS06685	COG1609	Transcriptional regulator
N16961_RS06690	COG0251	oxidation-reduction process
N16961_RS06695	COG2731	YhcH YjgK YiaL family protein
N16961_RS06700	COG0584	glycerophosphoryl diester phosphodiesterase
N16961_RS06705	COG1349	DNA-binding transcription factor activity
N16961_RS06710	COG3842	ATPase activity
N16961_RS06715	COG0395	ABC-type sugar transport system, permease component
N16961_RS06720	COG1175	transmembrane transport
N16961_RS06735	COG0811	peptide transport
N16961_RS06740	COG0811	peptide transport
N16961_RS06745	COG0848	biopolymer transport protein
N16961_RS06750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N16961_RS06765	COG1793	dna ligase
N16961_RS06775	COG0534	Mate efflux family protein
N16961_RS06785	COG3001	Fructosamine kinase
N16961_RS06795	COG0791	NLP P60 protein
N16961_RS06800	COG0840	transmembrane signaling receptor activity
N16961_RS06810	COG3148	PFAM DTW domain containing protein
N16961_RS06815	COG1940	carbohydrate kinase activity
N16961_RS06850	COG0746	molybdenum cofactor guanylyltransferase activity
N16961_RS06855	COG3842	ATPase activity
N16961_RS06860	COG4662	Binding-protein-dependent transport system inner membrane component
N16961_RS06870	COG2204	response regulator
N16961_RS06875	COG3852	Histidine kinase
N16961_RS06880	COG0488	(ABC) transporter
N16961_RS06885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N16961_RS06915	COG3383	formate dehydrogenase (NAD+) activity
N16961_RS06915	COG0243	molybdopterin cofactor binding
N16961_RS06920	COG0437	4 iron, 4 sulfur cluster binding
N16961_RS06935	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N16961_RS06940	COG1666	GTP binding
N16961_RS06945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N16961_RS06960	COG2996	Protein conserved in bacteria
N16961_RS06970	COG3008	intermembrane lipid transfer
N16961_RS06975	COG2995	paraquat-inducible protein a
N16961_RS06980	COG1132	(ABC) transporter
N16961_RS06985	COG1956	GAF domain-containing protein
N16961_RS06990	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
N16961_RS07005	COG0308	aminopeptidase N
N16961_RS07020	COG0167	dihydroorotate dehydrogenase activity
N16961_RS07030	COG0116	Belongs to the methyltransferase superfamily
N16961_RS07030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N16961_RS07040	COG0488	(ABC) transporter
N16961_RS07055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N16961_RS07060	COG1067	ATP-dependent peptidase activity
N16961_RS07065	COG3120	sequence-specific DNA binding
N16961_RS07160	COG1476	TRANSCRIPTIONal
N16961_RS07190	COG4128	Pfam Zonular occludens toxin
N16961_RS07210	COG1476	TRANSCRIPTIONal
N16961_RS07235	COG1476	TRANSCRIPTIONal
N16961_RS07255	COG3064	Membrane
N16961_RS07255	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
N16961_RS07255	COG1073	alpha beta
N16961_RS07260	COG2994	toxin metabolic process
N16961_RS07285	COG0784	Response regulator, receiver
N16961_RS07285	COG2205	protein histidine kinase activity
N16961_RS07300	COG3278	Belongs to the heme-copper respiratory oxidase family
N16961_RS07315	COG2010	Cytochrome c
N16961_RS07325	COG2217	Heavy metal translocating P-type atpase
N16961_RS07340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N16961_RS07345	COG0589	response to stress
N16961_RS07370	COG3842	ATPase activity
N16961_RS07380	COG1177	transmembrane transport
N16961_RS07390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N16961_RS07405	COG1115	amino acid carrier protein
N16961_RS07410	COG1280	lysine exporter protein (LysE YggA)
N16961_RS07425	COG3675	Pfam Lipase (class 3)
N16961_RS07435	COG3501	Rhs element vgr protein
N16961_RS07445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N16961_RS07455	COG2814	Major facilitator Superfamily
N16961_RS07460	COG1566	PFAM secretion protein HlyD family protein
N16961_RS07465	COG1538	Outer membrane efflux protein
N16961_RS07475	COG0513	Belongs to the DEAD box helicase family
N16961_RS07485	COG0840	transmembrane signaling receptor activity
N16961_RS07490	COG3290	protein histidine kinase activity
N16961_RS07490	COG0840	transmembrane signaling receptor activity
N16961_RS07495	COG0835	chemotaxis
N16961_RS07500	COG2201	protein-glutamate methylesterase activity
N16961_RS07510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N16961_RS07515	COG2198	Histidine kinase
N16961_RS07515	COG0784	Response regulator, receiver
N16961_RS07515	COG0643	Histidine kinase
N16961_RS07520	COG0643	Histidine kinase
N16961_RS07520	COG2198	Histidine kinase
N16961_RS07530	COG0745	RESPONSE REGULATOR receiver
N16961_RS07545	COG0415	Belongs to the DNA photolyase family
N16961_RS07550	COG0477	Major facilitator Superfamily
N16961_RS07555	COG0583	DNA-binding transcription factor activity
N16961_RS07565	COG0095	Lipoate-protein ligase
N16961_RS07570	COG0443	Heat shock 70 kDa protein
N16961_RS07580	COG1643	Atp-dependent helicase
N16961_RS07620	COG0443	Heat shock 70 kDa protein
N16961_RS07625	COG0443	Heat shock 70 kDa protein
N16961_RS07630	COG3706	GGDEF domain
N16961_RS07660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N16961_RS07665	COG0602	queuosine metabolic process
N16961_RS07675	COG0561	phosphatase activity
N16961_RS07685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_RS07690	COG4597	amino acid ABC transporter
N16961_RS07695	COG0765	amino acid transport
N16961_RS07700	COG1126	abc transporter atp-binding protein
N16961_RS07705	COG0670	Belongs to the BI1 family
N16961_RS07710	COG2920	part of a sulfur-relay system
N16961_RS07715	COG1254	Belongs to the acylphosphatase family
N16961_RS07720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N16961_RS07725	COG3706	GGDEF domain
N16961_RS07745	COG3437	response regulator, receiver
N16961_RS07750	COG0625	glutathione transferase activity
N16961_RS07760	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N16961_RS07770	COG2195	Cleaves the N-terminal amino acid of tripeptides
N16961_RS07800	COG0372	Belongs to the citrate synthase family
N16961_RS07805	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N16961_RS07845	COG1129	ABC transporter
N16961_RS07875	COG0745	RESPONSE REGULATOR receiver
N16961_RS07880	COG2205	protein histidine kinase activity
N16961_RS07885	COG3713	MltA-interacting MipA family protein
N16961_RS07890	COG2990	Protein conserved in bacteria
N16961_RS07900	COG4191	Histidine kinase
N16961_RS07900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_RS07905	COG0471	metal ion transport
N16961_RS07915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N16961_RS07935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_RS07945	COG3768	UPF0283 membrane protein
N16961_RS07950	COG3106	COG3106 Predicted ATPase
N16961_RS07965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N16961_RS07970	COG0494	nUDIX hydrolase
N16961_RS07975	COG0814	amino acid
N16961_RS07980	COG1760	l-serine dehydratase
N16961_RS07985	COG0720	synthase
N16961_RS07995	COG0017	Asparaginyl-tRNA synthetase
N16961_RS08000	COG0351	phosphomethylpyrimidine kinase
N16961_RS08005	COG2770	Histidine kinase
N16961_RS08005	COG3437	response regulator, receiver
N16961_RS08015	COG1448	Aminotransferase
N16961_RS08030	COG0840	transmembrane signaling receptor activity
N16961_RS08035	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
N16961_RS08040	COG2943	transferase activity, transferring hexosyl groups
N16961_RS08045	COG1609	Transcriptional regulator
N16961_RS08055	COG1486	melibiose metabolic process
N16961_RS08060	COG1447	Phosphotransferase system cellobiose-specific component IIA
N16961_RS08070	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N16961_RS08075	COG0726	polysaccharide deacetylase
N16961_RS08080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N16961_RS08085	COG1846	Transcriptional regulator
N16961_RS08115	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N16961_RS08130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N16961_RS08135	COG3108	Peptidase M15
N16961_RS08140	COG2989	Protein conserved in bacteria
N16961_RS08165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N16961_RS08175	COG2814	Major facilitator Superfamily
N16961_RS08185	COG1054	Belongs to the UPF0176 family
N16961_RS08195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N16961_RS08200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N16961_RS08205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N16961_RS08260	COG4139	cobalamin transport
N16961_RS08280	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N16961_RS08285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N16961_RS08295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_RS08300	COG1823	symporter activity
N16961_RS08305	COG2925	Exonuclease
N16961_RS08310	COG1380	Effector of murein hydrolase LrgA
N16961_RS08315	COG1346	cytolysis
N16961_RS08355	COG0776	regulation of translation
N16961_RS08360	COG0072	phenylalanine-tRNA ligase activity
N16961_RS08360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_RS08365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N16961_RS08405	COG0322	excinuclease ABC activity
N16961_RS08410	COG2197	response regulator
N16961_RS08415	COG0417	DNA replication proofreading
N16961_RS08420	COG5001	Diguanylate cyclase
N16961_RS08430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N16961_RS08435	COG3099	Belongs to the UPF0263 family
N16961_RS08450	COG1228	amidohydrolase
N16961_RS08455	COG0010	Belongs to the arginase family
N16961_RS08460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N16961_RS08465	COG2986	histidine ammonia-lyase
N16961_RS08485	COG0247	lactate metabolic process
N16961_RS08485	COG0277	FAD linked oxidase domain protein
N16961_RS08500	COG2885	chlorophyll binding
N16961_RS08520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N16961_RS08530	COG0281	malic enzyme
N16961_RS08540	COG2949	membrane
N16961_RS08545	COG3706	GGDEF domain
N16961_RS08550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N16961_RS08560	COG0492	ferredoxin-NADP+ reductase activity
N16961_RS08565	COG4988	ABC transporter
N16961_RS08570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N16961_RS08575	COG1187	pseudouridine synthase activity
N16961_RS08580	COG0009	L-threonylcarbamoyladenylate synthase
N16961_RS08585	COG0613	PHP domain protein
N16961_RS08595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N16961_RS08600	COG0512	Glutamine amidotransferase of anthranilate synthase
N16961_RS08605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N16961_RS08610	COG0135	phosphoribosylanthranilate isomerase activity
N16961_RS08610	COG0134	indole-3-glycerol-phosphate synthase activity
N16961_RS08615	COG0133	tryptophan synthase activity
N16961_RS08620	COG0159	tryptophan synthase activity
N16961_RS08630	COG1435	thymidine kinase activity
N16961_RS08635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N16961_RS08640	COG1801	Protein of unknown function DUF72
N16961_RS08645	COG4106	trans-aconitate 2-methyltransferase activity
N16961_RS08650	COG0500	methyltransferase
N16961_RS08670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N16961_RS08680	COG3852	Histidine kinase
N16961_RS08695	COG3070	regulator of competence-specific genes
N16961_RS08705	COG2431	L-lysine efflux transmembrane transporter activity
N16961_RS08715	COG0076	glutamate decarboxylase activity
N16961_RS08720	COG1737	Transcriptional regulator
N16961_RS08725	COG1454	alcohol dehydrogenase
N16961_RS08725	COG1012	belongs to the aldehyde dehydrogenase family
N16961_RS08730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N16961_RS08735	COG2985	domain, Protein
N16961_RS08735	COG3273	potassium ion transport
N16961_RS08740	COG0542	response to heat
N16961_RS08745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N16961_RS08750	COG1278	Cold shock
N16961_RS08760	COG1187	pseudouridine synthase activity
N16961_RS08765	COG0140	phosphoribosyl-ATP diphosphatase activity
N16961_RS08765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N16961_RS08770	COG0107	imidazoleglycerol-phosphate synthase activity
N16961_RS08775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N16961_RS08780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N16961_RS08785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N16961_RS08785	COG0131	Imidazoleglycerol-phosphate dehydratase
N16961_RS08790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N16961_RS08795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N16961_RS08800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N16961_RS08805	COG1757	Na H antiporter
N16961_RS08810	COG2916	Histone family protein nucleoid-structuring protein H-NS
N16961_RS08815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_RS08820	COG0482	sulfurtransferase activity
N16961_RS08825	COG2915	High frequency lysogenization protein hflD homolog
N16961_RS08830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N16961_RS08840	COG2268	Band 7 protein
N16961_RS08850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N16961_RS08865	COG0300	oxidoreductase activity
N16961_RS08875	COG0501	Belongs to the peptidase M48B family
N16961_RS08885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N16961_RS08890	COG2226	methyltransferase
N16961_RS08895	COG0156	8-amino-7-oxononanoate synthase activity
N16961_RS08900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N16961_RS08905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N16961_RS08910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N16961_RS08915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N16961_RS08920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N16961_RS08930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N16961_RS08935	COG2203	Gaf domain
N16961_RS08935	COG2199	diguanylate cyclase activity
N16961_RS08945	COG4120	Belongs to the binding-protein-dependent transport system permease family
N16961_RS08955	COG4628	conserved protein (DUF2132)
N16961_RS08960	COG3092	negative regulation of chromosome organization
N16961_RS08965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N16961_RS08970	COG0280	phosphate acetyltransferase
N16961_RS08970	COG0857	belongs to the CobB CobQ family
N16961_RS08975	COG0435	Glutathione S-transferase
N16961_RS08980	COG4608	Belongs to the ABC transporter superfamily
N16961_RS08985	COG0444	Belongs to the ABC transporter superfamily
N16961_RS08990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_RS08995	COG0601	transmembrane transport
N16961_RS09015	COG2204	response regulator
N16961_RS09020	COG3300	MHYT domain
N16961_RS09020	COG5001	Diguanylate cyclase
N16961_RS09025	COG4191	Histidine kinase
N16961_RS09030	COG5002	protein histidine kinase activity
N16961_RS09040	COG2201	protein-glutamate methylesterase activity
N16961_RS09055	COG0009	L-threonylcarbamoyladenylate synthase
N16961_RS09075	COG1881	PFAM PEBP family protein
N16961_RS09100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N16961_RS09105	COG0640	Transcriptional regulator
N16961_RS09115	COG3706	GGDEF domain
N16961_RS09135	COG1946	Acyl-CoA thioesterase
N16961_RS09140	COG1522	sequence-specific DNA binding
N16961_RS09150	COG0616	signal peptide processing
N16961_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_RS09160	COG2983	Belongs to the UPF0260 family
N16961_RS09170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N16961_RS09175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N16961_RS09185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N16961_RS09190	COG2832	Protein of unknown function (DUF454)
N16961_RS09200	COG0745	RESPONSE REGULATOR receiver
N16961_RS09205	COG0583	DNA-binding transcription factor activity
N16961_RS09210	COG0778	Nitroreductase
N16961_RS09215	COG1024	Enoyl-CoA hydratase
N16961_RS09215	COG1250	3-hydroxyacyl-CoA dehydrogenase
N16961_RS09220	COG0183	Belongs to the thiolase family
N16961_RS09240	COG2067	long-chain fatty acid transport protein
N16961_RS09250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N16961_RS09255	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
N16961_RS09260	COG2982	Protein involved in outer membrane biogenesis
N16961_RS09265	COG0572	uridine kinase
N16961_RS09275	COG0489	protein tyrosine kinase activity
N16961_RS09280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_RS09280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N16961_RS09290	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N16961_RS09305	COG0517	IMP dehydrogenase activity
N16961_RS09305	COG0617	tRNA 3'-terminal CCA addition
N16961_RS09305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N16961_RS09310	COG2199	diguanylate cyclase activity
N16961_RS09315	COG0314	molybdopterin synthase activity
N16961_RS09320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N16961_RS09325	COG0315	cyclic pyranopterin monophosphate synthase activity
N16961_RS09330	COG0521	Mo-molybdopterin cofactor biosynthetic process
N16961_RS09335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N16961_RS09340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N16961_RS09345	COG2198	Histidine kinase
N16961_RS09350	COG2204	response regulator
N16961_RS09360	COG0556	nucleotide-excision repair
N16961_RS09370	COG4657	Part of a membrane complex involved in electron transport
N16961_RS09375	COG2878	Part of a membrane complex involved in electron transport
N16961_RS09380	COG4656	Part of a membrane complex involved in electron transport
N16961_RS09400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N16961_RS09405	COG0346	lactoylglutathione lyase activity
N16961_RS09420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N16961_RS09425	COG2056	Na+-H+ antiporter family
N16961_RS09430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N16961_RS09435	COG1286	toxin biosynthetic process
N16961_RS09440	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
N16961_RS09445	COG0285	dihydrofolate synthase activity
N16961_RS09450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N16961_RS09455	COG0101	tRNA pseudouridine synthase activity
N16961_RS09470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_RS09470	COG2190	(PTS) system
N16961_RS09470	COG1263	PTS System
N16961_RS09475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N16961_RS09480	COG1846	Transcriptional regulator
N16961_RS09480	COG1940	carbohydrate kinase activity
N16961_RS09485	COG4651	solute:proton antiporter activity
N16961_RS09485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N16961_RS09490	COG0367	asparagine synthase
N16961_RS09505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N16961_RS09510	COG0563	adenylate kinase activity
N16961_RS09515	COG0326	Molecular chaperone. Has ATPase activity
N16961_RS09520	COG3710	Transcriptional regulator
N16961_RS09535	COG0622	Phosphoesterase
N16961_RS09540	COG1090	epimerase
N16961_RS09545	COG0300	oxidoreductase activity
N16961_RS09555	COG3118	belongs to the thioredoxin family
N16961_RS09565	COG0330	HflC and HflK could
N16961_RS09570	COG1585	Membrane protein implicated in regulation of membrane protease activity
N16961_RS09575	COG0789	Transcriptional regulator
N16961_RS09595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N16961_RS09600	COG3115	cell septum assembly
N16961_RS09605	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
N16961_RS09610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N16961_RS09620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_RS09630	COG2190	(PTS) system
N16961_RS09635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N16961_RS09640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N16961_RS09645	COG1702	phosphate starvation-inducible protein PhoH
N16961_RS09655	COG4535	Mg2 and Co2 transporter CorC
N16961_RS09660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N16961_RS09665	COG2888	peptidyl-tyrosine sulfation
N16961_RS09670	COG0495	leucyl-tRNA aminoacylation
N16961_RS09675	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N16961_RS09680	COG1466	dna polymerase III delta subunit
N16961_RS09685	COG0799	negative regulation of ribosome biogenesis
N16961_RS09690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N16961_RS09695	COG0768	penicillin binding
N16961_RS09700	COG0772	Belongs to the SEDS family
N16961_RS09705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N16961_RS09710	COG1686	Belongs to the peptidase S11 family
N16961_RS09715	COG2921	Belongs to the UPF0250 family
N16961_RS09720	COG0321	lipoyl(octanoyl) transferase activity
N16961_RS09725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N16961_RS09735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N16961_RS09760	COG1596	polysaccharide export
N16961_RS09770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N16961_RS09800	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N16961_RS09810	COG0438	transferase activity, transferring glycosyl groups
N16961_RS09820	COG1045	serine acetyltransferase
N16961_RS09840	COG0110	maltose O-acetyltransferase activity
N16961_RS09845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N16961_RS09850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N16961_RS09855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N16961_RS09860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N16961_RS09890	COG0366	Alpha amylase catalytic
N16961_RS09895	COG1263	PTS System
N16961_RS09895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_RS09900	COG1609	Transcriptional regulator
N16961_RS09905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N16961_RS09910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N16961_RS09915	COG2011	ABC-type metal ion transport system permease component
N16961_RS09920	COG1464	Belongs to the NlpA lipoprotein family
N16961_RS09925	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N16961_RS09935	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N16961_RS09935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N16961_RS09950	COG1611	Belongs to the LOG family
N16961_RS09955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N16961_RS09960	COG2363	Small membrane protein
N16961_RS09965	COG0583	DNA-binding transcription factor activity
N16961_RS09970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N16961_RS09970	COG0301	tRNA thio-modification
N16961_RS09980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N16961_RS09985	COG1722	exodeoxyribonuclease VII activity
N16961_RS09990	COG0142	geranyltranstransferase activity
N16961_RS09995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N16961_RS10000	COG0564	pseudouridine synthase activity
N16961_RS10005	COG3098	single-species biofilm formation
N16961_RS10020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_RS10030	COG1671	Belongs to the UPF0178 family
N16961_RS10035	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N16961_RS10040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N16961_RS10045	COG0254	rRNA binding
N16961_RS10050	COG1720	tRNA m6t6A37 methyltransferase activity
N16961_RS10055	COG0442	prolyl-tRNA aminoacylation
N16961_RS10085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N16961_RS10085	COG0047	phosphoribosylformylglycinamidine synthase activity
N16961_RS10095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N16961_RS10105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N16961_RS10130	COG4968	Prepilin-type N-terminal cleavage methylation domain
N16961_RS10140	COG0484	heat shock protein binding
N16961_RS10145	COG0443	Heat shock 70 kDa protein
N16961_RS10150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N16961_RS10155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N16961_RS10160	COG0497	DNA recombination
N16961_RS10165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N16961_RS10170	COG2914	Belongs to the UPF0125 (RnfH) family
N16961_RS10175	COG2867	negative regulation of translational initiation
N16961_RS10180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N16961_RS10190	COG0582	viral genome integration into host DNA
N16961_RS10200	COG0582	viral genome integration into host DNA
N16961_RS10205	COG3064	Membrane
N16961_RS10215	COG0739	heme binding
N16961_RS10230	COG0840	transmembrane signaling receptor activity
N16961_RS10235	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
N16961_RS10240	COG2207	Transcriptional regulator
N16961_RS10250	COG1459	type II secretion system
N16961_RS10255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_RS10275	COG4796	Type ii and iii secretion system protein
N16961_RS10290	COG2165	general secretion pathway protein
N16961_RS10300	COG3710	Transcriptional regulator
N16961_RS10305	COG0840	transmembrane signaling receptor activity
N16961_RS10310	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N16961_RS10330	COG1012	belongs to the aldehyde dehydrogenase family
N16961_RS10395	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N16961_RS10400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N16961_RS10405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N16961_RS10425	COG3051	citrate lyase alpha subunit
N16961_RS10430	COG2301	Belongs to the HpcH HpaI aldolase family
N16961_RS10440	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
N16961_RS10450	COG3630	sodium ion export across plasma membrane
N16961_RS10455	COG5016	pyruvate
N16961_RS10455	COG0511	ligase activity, forming carbon-carbon bonds
N16961_RS10460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N16961_RS10470	COG4565	transcriptional regulatory protein
N16961_RS10485	COG0583	DNA-binding transcription factor activity
N16961_RS10495	COG1115	amino acid carrier protein
N16961_RS10500	COG2015	COG2015, Alkyl sulfatase and related hydrolases
N16961_RS10505	COG0583	DNA-binding transcription factor activity
N16961_RS10515	COG1120	ATPase activity
N16961_RS10520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_RS10525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_RS10530	COG4592	Periplasmic binding protein
N16961_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_RS10545	COG1169	isochorismate synthase
N16961_RS10550	COG1021	2,3-dihydroxybenzoate-AMP ligase
N16961_RS10555	COG1535	isochorismatase
N16961_RS10555	COG3433	isochorismatase activity
N16961_RS10560	COG1584	GPR1 FUN34 yaaH family protein
N16961_RS10570	COG0519	Catalyzes the synthesis of GMP from XMP
N16961_RS10570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N16961_RS10575	COG0516	GMP reductase activity
N16961_RS10575	COG0517	IMP dehydrogenase activity
N16961_RS10580	COG1570	exodeoxyribonuclease VII activity
N16961_RS10595	COG1160	GTP binding
N16961_RS10600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N16961_RS10605	COG2976	Protein conserved in bacteria
N16961_RS10610	COG0124	histidyl-tRNA synthetase
N16961_RS10615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N16961_RS10625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N16961_RS10630	COG0105	UTP biosynthetic process
N16961_RS10635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N16961_RS10640	COG2975	iron-sulfur cluster assembly
N16961_RS10645	COG0633	Ferredoxin
N16961_RS10650	COG0443	Heat shock 70 kDa protein
N16961_RS10655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N16961_RS10665	COG0822	iron-sulfur transferase activity
N16961_RS10670	COG1104	cysteine desulfurase activity
N16961_RS10675	COG1959	2 iron, 2 sulfur cluster binding
N16961_RS10685	COG0483	inositol monophosphate 1-phosphatase activity
N16961_RS10690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_RS10695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_RS10700	COG1862	Preprotein translocase
N16961_RS10720	COG0517	IMP dehydrogenase activity
N16961_RS10730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N16961_RS10735	COG0583	DNA-binding transcription factor activity
N16961_RS10740	COG0450	alkyl hydroperoxide reductase
N16961_RS10745	COG3142	Participates in the control of copper homeostasis
N16961_RS10760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N16961_RS10765	COG0581	inorganic phosphate transmembrane transporter activity
N16961_RS10775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N16961_RS10780	COG0248	Ppx GppA phosphatase
N16961_RS10790	COG5002	protein histidine kinase activity
N16961_RS10795	COG0745	RESPONSE REGULATOR receiver
N16961_RS10805	COG0826	peptidase U32
N16961_RS10810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N16961_RS10850	COG0542	response to heat
N16961_RS10860	COG0564	pseudouridine synthase activity
N16961_RS10865	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N16961_RS10870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N16961_RS10875	COG0077	Prephenate dehydratase
N16961_RS10875	COG1605	Chorismate mutase
N16961_RS10880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N16961_RS10885	COG5001	Diguanylate cyclase
N16961_RS10895	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
N16961_RS10905	COG0488	(ABC) transporter
N16961_RS10915	COG0287	Prephenate dehydrogenase
N16961_RS10915	COG1605	Chorismate mutase
N16961_RS10920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N16961_RS10925	COG3275	phosphorelay sensor kinase activity
N16961_RS10930	COG3279	Response regulator of the LytR AlgR family
N16961_RS10940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N16961_RS10945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N16961_RS10960	COG1966	Carbon starvation protein
N16961_RS10965	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N16961_RS10970	COG1047	Peptidyl-prolyl cis-trans
N16961_RS10985	COG0196	riboflavin kinase activity
N16961_RS10990	COG0728	peptidoglycan biosynthetic process
N16961_RS10995	COG0268	Binds directly to 16S ribosomal RNA
N16961_RS11000	COG0640	Transcriptional regulator
N16961_RS11005	COG0583	DNA-binding transcription factor activity
N16961_RS11010	COG1283	sodium-dependent phosphate transmembrane transporter activity
N16961_RS11020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N16961_RS11025	COG0730	response to heat
N16961_RS11030	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
N16961_RS11035	COG0494	nUDIX hydrolase
N16961_RS11045	COG0667	Aldo Keto reductase
N16961_RS11055	COG2204	response regulator
N16961_RS11060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N16961_RS11080	COG0513	Belongs to the DEAD box helicase family
N16961_RS11105	COG3153	acetyltransferase
N16961_RS11110	COG3154	lipid carrier protein
N16961_RS11120	COG0826	peptidase U32
N16961_RS11125	COG0826	peptidase U32
N16961_RS11150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N16961_RS11160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N16961_RS11165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N16961_RS11170	COG0195	Participates in both transcription termination and antitermination
N16961_RS11175	COG0779	Required for maturation of 30S ribosomal subunits
N16961_RS11190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N16961_RS11205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N16961_RS11210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N16961_RS11215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N16961_RS11220	COG1534	Rna-binding protein
N16961_RS11225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N16961_RS11230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N16961_RS11235	COG2027	D-alanyl-D-alanine carboxypeptidase
N16961_RS11240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N16961_RS11245	COG0739	heme binding
N16961_RS11260	COG0316	Belongs to the HesB IscA family
N16961_RS11265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N16961_RS11270	COG0628	permease
N16961_RS11275	COG2813	Specifically methylates the guanine in position
N16961_RS11280	COG0784	Response regulator, receiver
N16961_RS11280	COG2205	protein histidine kinase activity
N16961_RS11290	COG0747	negative chemotaxis
N16961_RS11295	COG0601	transmembrane transport
N16961_RS11300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_RS11305	COG0444	Belongs to the ABC transporter superfamily
N16961_RS11310	COG4608	Belongs to the ABC transporter superfamily
N16961_RS11320	COG2971	BadF BadG BcrA BcrD
N16961_RS11340	COG3842	ATPase activity
N16961_RS11350	COG1840	ABC-type Fe3 transport system, periplasmic component
N16961_RS11355	COG0004	ammonium transporteR
N16961_RS11360	COG0347	Belongs to the P(II) protein family
N16961_RS11365	COG3112	Uncharacterised protein family (UPF0231)
N16961_RS11370	COG1049	propionate catabolic process, 2-methylcitrate cycle
N16961_RS11375	COG1752	Esterase of the alpha-beta hydrolase superfamily
N16961_RS11380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N16961_RS11385	COG1643	Atp-dependent helicase
N16961_RS11395	COG1489	DNA binding
N16961_RS11405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N16961_RS11415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N16961_RS11420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N16961_RS11425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N16961_RS11430	COG0842	Transport permease protein
N16961_RS11435	COG1131	(ABC) transporter
N16961_RS11440	COG0659	secondary active sulfate transmembrane transporter activity
N16961_RS11445	COG0288	reversible hydration of carbon dioxide
N16961_RS11465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N16961_RS11470	COG3107	peptidoglycan biosynthetic process
N16961_RS11475	COG0792	nuclease activity
N16961_RS11480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N16961_RS11485	COG2823	Periplasmic or secreted lipoprotein
N16961_RS11490	COG2969	positive regulation of protein catabolic process
N16961_RS11495	COG0625	glutathione transferase activity
N16961_RS11500	COG2857	Cytochrome c1
N16961_RS11505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N16961_RS11510	COG0723	plastoquinol--plastocyanin reductase activity
N16961_RS11515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N16961_RS11520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N16961_RS11525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N16961_RS11535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N16961_RS11540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N16961_RS11545	COG0335	large ribosomal subunit rRNA binding
N16961_RS11550	COG0336	Belongs to the RNA methyltransferase TrmD family
N16961_RS11555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N16961_RS11560	COG0228	four-way junction DNA binding
N16961_RS11565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N16961_RS11570	COG4137	Cytochrome C assembly protein
N16961_RS11575	COG4536	flavin adenine dinucleotide binding
N16961_RS11580	COG1854	S-ribosylhomocysteine lyase activity
N16961_RS11585	COG2918	glutathione biosynthetic process
N16961_RS11590	COG0612	Peptidase, M16
N16961_RS11595	COG1238	metal cluster binding
N16961_RS11605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N16961_RS11610	COG5016	pyruvate
N16961_RS11610	COG0511	ligase activity, forming carbon-carbon bonds
N16961_RS11615	COG3630	sodium ion export across plasma membrane
N16961_RS11660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N16961_RS11665	COG0527	aspartate kinase activity
N16961_RS11670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N16961_RS11680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N16961_RS11690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N16961_RS11695	COG4208	sulfate ABC transporter
N16961_RS11715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N16961_RS11720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N16961_RS11730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N16961_RS11735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N16961_RS11740	COG0585	pseudouridine synthase activity
N16961_RS11745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N16961_RS11750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N16961_RS11755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N16961_RS11760	COG1968	undecaprenyl-diphosphatase activity
N16961_RS11765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N16961_RS11770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N16961_RS11780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N16961_RS11790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N16961_RS11795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N16961_RS11800	COG1610	YqeY-like protein
N16961_RS11805	COG0358	DNA primase activity
N16961_RS11820	COG0582	viral genome integration into host DNA
N16961_RS11825	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N16961_RS11830	COG0840	transmembrane signaling receptor activity
N16961_RS11835	COG2207	Transcriptional regulator
N16961_RS11840	COG0840	transmembrane signaling receptor activity
N16961_RS11850	COG2003	Belongs to the UPF0758 family
N16961_RS11885	COG0739	heme binding
N16961_RS11895	COG4969	Belongs to the N-Me-Phe pilin family
N16961_RS11910	COG0328	RNA-DNA hybrid ribonuclease activity
N16961_RS11960	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N16961_RS11965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N16961_RS11970	COG1349	DNA-binding transcription factor activity
N16961_RS11990	COG1279	arginine transmembrane transporter activity
N16961_RS11995	COG0668	transmembrane transport
N16961_RS12005	COG0191	fructose-bisphosphate aldolase activity
N16961_RS12010	COG0126	phosphoglycerate kinase activity
N16961_RS12015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N16961_RS12020	COG4771	TonB-dependent receptor
N16961_RS12025	COG0583	DNA-binding transcription factor activity
N16961_RS12030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N16961_RS12035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N16961_RS12045	COG2356	endonuclease I
N16961_RS12050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N16961_RS12055	COG0189	ligase activity
N16961_RS12060	COG1678	Uncharacterized ACR, COG1678
N16961_RS12065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N16961_RS12070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N16961_RS12090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N16961_RS12095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N16961_RS12100	COG0762	integral membrane protein
N16961_RS12105	COG1872	DUF167
N16961_RS12115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N16961_RS12120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N16961_RS12125	COG2066	Belongs to the glutaminase family
N16961_RS12135	COG1194	a g-specific adenine glycosylase
N16961_RS12140	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N16961_RS12145	COG0741	lytic transglycosylase activity
N16961_RS12200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N16961_RS12205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N16961_RS12210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N16961_RS12215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N16961_RS12220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N16961_RS12225	COG2967	ApaG domain
N16961_RS12230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N16961_RS12240	COG3610	response to peptide
N16961_RS12245	COG2966	Psort location CytoplasmicMembrane, score
N16961_RS12250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N16961_RS12255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N16961_RS12260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N16961_RS12265	COG0142	geranyltranstransferase activity
N16961_RS12270	COG0531	amino acid
N16961_RS12275	COG0039	L-malate dehydrogenase activity
N16961_RS12280	COG1438	arginine binding
N16961_RS12290	COG2358	TRAP transporter, solute receptor (TAXI family
N16961_RS12300	COG0589	response to stress
N16961_RS12320	COG2235	arginine
N16961_RS12325	COG0312	modulator of DNA gyrase
N16961_RS12330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N16961_RS12335	COG3164	Protein of unknown function
N16961_RS12345	COG0424	maF-like protein
N16961_RS12350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N16961_RS12355	COG1792	Involved in formation and maintenance of cell shape
N16961_RS12360	COG1077	Cell shape determining protein MreB Mrl
N16961_RS12390	COG2165	general secretion pathway protein
N16961_RS12395	COG2165	general secretion pathway protein
N16961_RS12405	COG1459	type II secretion system
N16961_RS12410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N16961_RS12420	COG3409	Peptidoglycan-binding domain 1 protein
N16961_RS12420	COG3267	Type II secretory pathway component ExeA
N16961_RS12445	COG2200	EAL domain
N16961_RS12445	COG2199	diguanylate cyclase activity
N16961_RS12450	COG0629	single-stranded DNA binding
N16961_RS12465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N16961_RS12475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N16961_RS12480	COG0527	aspartate kinase activity
N16961_RS12485	COG0646	methionine synthase
N16961_RS12485	COG1410	methionine synthase
N16961_RS12580	COG0175	sulfate reduction
N16961_RS12590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N16961_RS12615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N16961_RS12620	COG0735	belongs to the Fur family
N16961_RS12640	COG0432	Pfam Uncharacterised protein family UPF0047
N16961_RS12645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N16961_RS12660	COG0359	binds to the 23S rRNA
N16961_RS12665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N16961_RS12670	COG2965	DNA replication, synthesis of RNA primer
N16961_RS12675	COG0360	Binds together with S18 to 16S ribosomal RNA
N16961_RS12685	COG2906	2 iron, 2 sulfur cluster binding
N16961_RS12690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N16961_RS12695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N16961_RS12700	COG0049	tRNA binding
N16961_RS12705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N16961_RS12715	COG2923	Belongs to the DsrF TusC family
N16961_RS12720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N16961_RS12725	COG2964	Protein conserved in bacteria
N16961_RS12730	COG0545	Peptidyl-prolyl cis-trans isomerase
N16961_RS12740	COG2900	Belongs to the SlyX family
N16961_RS12745	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
N16961_RS12750	COG0330	HflC and HflK could
N16961_RS12755	COG0330	HflC and HflK could
N16961_RS12760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N16961_RS12765	COG1923	regulation of RNA biosynthetic process
N16961_RS12770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N16961_RS12775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N16961_RS12785	COG0802	atpase or kinase
N16961_RS12790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N16961_RS12835	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N16961_RS12840	COG1162	GTPase activity
N16961_RS12845	COG0688	phosphatidylethanolamine metabolic process
N16961_RS12850	COG0490	domain, Protein
N16961_RS12850	COG0471	metal ion transport
N16961_RS12860	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N16961_RS12865	COG4942	peptidase
N16961_RS12880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N16961_RS12885	COG2816	NAD+ diphosphatase activity
N16961_RS12890	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
N16961_RS12895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N16961_RS12900	COG0085	RNA polymerase activity
N16961_RS12905	COG0222	ribosome binding
N16961_RS12910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N16961_RS12920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N16961_RS12925	COG0250	Participates in transcription elongation, termination and antitermination
N16961_RS12930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N16961_RS12935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N16961_RS12960	COG1072	(Pantothenic acid kinase))
N16961_RS12970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N16961_RS12980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N16961_RS13025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N16961_RS13040	COG3118	belongs to the thioredoxin family
N16961_RS13045	COG0513	Belongs to the DEAD box helicase family
N16961_RS13050	COG0248	Ppx GppA phosphatase
N16961_RS13055	COG2205	protein histidine kinase activity
N16961_RS13055	COG0784	Response regulator, receiver
N16961_RS13060	COG2814	Major facilitator Superfamily
N16961_RS13080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N16961_RS13085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N16961_RS13090	COG0511	ligase activity, forming carbon-carbon bonds
N16961_RS13095	COG0439	Biotin carboxylase
N16961_RS13100	COG2264	protein methyltransferase activity
N16961_RS13105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N16961_RS13110	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N16961_RS13115	COG1609	Transcriptional regulator
N16961_RS13120	COG0129	dihydroxy-acid dehydratase activity
N16961_RS13125	COG3265	gluconokinase activity
N16961_RS13135	COG0800	Aldolase
N16961_RS13155	COG0840	transmembrane signaling receptor activity
N16961_RS13160	COG1982	Orn Lys Arg decarboxylase major
N16961_RS13165	COG0531	amino acid
N16961_RS13170	COG3710	Transcriptional regulator
N16961_RS13175	COG0789	Transcriptional regulator
N16961_RS13190	COG0151	Belongs to the GarS family
N16961_RS13200	COG0776	regulation of translation
N16961_RS13205	COG1253	flavin adenine dinucleotide binding
N16961_RS13210	COG1940	carbohydrate kinase activity
N16961_RS13220	COG3068	Protein conserved in bacteria
N16961_RS13230	COG1573	uracil-dna glycosylase
N16961_RS13235	COG0668	transmembrane transport
N16961_RS13240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N16961_RS13245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N16961_RS13305	COG1454	alcohol dehydrogenase
N16961_RS13305	COG1012	belongs to the aldehyde dehydrogenase family
N16961_RS13310	COG0318	PFAM AMP-dependent synthetase and ligase
N16961_RS13340	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
N16961_RS13345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N16961_RS13350	COG0662	Cupin 2, conserved barrel domain protein
N16961_RS13350	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
N16961_RS13355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N16961_RS13390	COG1519	Transferase
N16961_RS13420	COG3642	lipopolysaccharide core region biosynthetic process
N16961_RS13425	COG0859	PFAM glycosyl transferase family 9
N16961_RS13430	COG0463	Glycosyl transferase, family 2
N16961_RS13435	COG0859	PFAM glycosyl transferase family 9
N16961_RS13440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N16961_RS13445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N16961_RS13455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N16961_RS13460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N16961_RS13465	COG2003	Belongs to the UPF0758 family
N16961_RS13475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N16961_RS13485	COG1309	transcriptional regulator
N16961_RS13490	COG1560	Kdo2-lipid A biosynthetic process
N16961_RS13495	COG1560	Kdo2-lipid A biosynthetic process
N16961_RS13500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N16961_RS13505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N16961_RS13510	COG1561	YicC-like family, N-terminal region
N16961_RS13515	COG2862	Uncharacterized protein family, UPF0114
N16961_RS13520	COG1263	PTS System
N16961_RS13520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_RS13525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N16961_RS13550	COG1120	ATPase activity
N16961_RS13555	COG4774	siderophore transport
N16961_RS13560	COG1132	(ABC) transporter
N16961_RS13575	COG0514	ATP-dependent DNA helicase (RecQ)
N16961_RS13580	COG2962	Rard protein
N16961_RS13595	COG1280	lysine exporter protein (LysE YggA)
N16961_RS13610	COG0210	DNA helicase
N16961_RS13620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N16961_RS13625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N16961_RS13665	COG3621	Patatin-like phospholipase
N16961_RS13690	COG2131	deaminase
N16961_RS13700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_RS13705	COG0601	transmembrane transport
N16961_RS13710	COG0747	negative chemotaxis
N16961_RS13765	COG1309	transcriptional regulator
N16961_RS13770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N16961_RS13775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N16961_RS13780	COG2960	long-chain fatty acid transporting porin activity
N16961_RS13785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N16961_RS13790	COG0583	DNA-binding transcription factor activity
N16961_RS13835	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
N16961_RS13840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N16961_RS13845	COG1739	Uncharacterized protein family UPF0029
N16961_RS13855	COG0183	Belongs to the thiolase family
N16961_RS13860	COG0583	DNA-binding transcription factor activity
N16961_RS13865	COG2814	Major facilitator Superfamily
N16961_RS13870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N16961_RS13875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N16961_RS13880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N16961_RS13885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N16961_RS13890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N16961_RS13895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N16961_RS13900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N16961_RS13910	COG0356	it plays a direct role in the translocation of protons across the membrane
N16961_RS13915	COG3312	ion transport
N16961_RS13920	COG1475	DNA binding
N16961_RS13925	COG1192	Involved in chromosome partitioning
N16961_RS13935	COG0445	tRNA wobble uridine modification
N16961_RS13945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N16961_RS13950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N16961_RS13955	COG0706	membrane insertase activity
N16961_RS13965	COG0594	ribonuclease P activity
N16961_RS13970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N16961_RS13975	COG1126	abc transporter atp-binding protein
N16961_RS14025	COG0217	transcriptional regulatory protein
N16961_RS14030	COG2084	Dehydrogenase
N16961_RS14050	COG2909	trisaccharide binding
N16961_RS14055	COG0058	SHG alpha-glucan phosphorylase activity
N16961_RS14060	COG1640	4-alpha-glucanotransferase
N16961_RS14065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N16961_RS14080	COG3501	Rhs element vgr protein
N16961_RS14085	COG4104	PAAR repeat-containing protein
N16961_RS14115	COG0471	metal ion transport
N16961_RS14120	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N16961_RS14165	COG0671	phosphoesterase, PA-phosphatase related
N16961_RS14170	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N16961_RS14180	COG1999	signal sequence binding
N16961_RS14195	COG0786	glutamate:sodium symporter activity
N16961_RS14215	COG1566	PFAM secretion protein HlyD family protein
N16961_RS14240	COG0813	purine-nucleoside phosphorylase activity
N16961_RS14250	COG3272	Protein of unknown function (DUF1722)
N16961_RS14260	COG0415	Belongs to the DNA photolyase family
N16961_RS14265	COG1388	LysM domain
N16961_RS14265	COG1376	ErfK ybiS ycfS ynhG family protein
N16961_RS14275	COG0513	Belongs to the DEAD box helicase family
N16961_RS14280	COG1770	oligopeptidase
N16961_RS14310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N16961_RS14315	COG0573	inorganic phosphate transmembrane transporter activity
N16961_RS14320	COG0581	inorganic phosphate transmembrane transporter activity
N16961_RS14325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N16961_RS14345	COG3314	Sporulation integral membrane protein YlbJ
N16961_RS14350	COG0659	secondary active sulfate transmembrane transporter activity
N16961_RS14360	COG0739	heme binding
N16961_RS14365	COG5001	Diguanylate cyclase
N16961_RS14365	COG3300	MHYT domain
N16961_RS14370	COG0583	DNA-binding transcription factor activity
N16961_RS14375	COG2814	Major facilitator Superfamily
N16961_RS14400	COG1301	dicarboxylic acid transport
N16961_RS14410	COG1342	Belongs to the UPF0251 family
N16961_RS14445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N16961_RS14450	COG0673	inositol 2-dehydrogenase activity
N16961_RS14460	COG2200	EAL domain
N16961_RS14460	COG2771	luxR family
N16961_RS14465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N16961_RS14475	COG0564	pseudouridine synthase activity
N16961_RS14540	COG3829	transcription factor binding
N16961_RS14570	COG3501	Rhs element vgr protein
N16961_RS14570	COG3409	Peptidoglycan-binding domain 1 protein
N16961_RS14585	COG1869	D-ribose catabolic process
N16961_RS14590	COG1129	ABC transporter
N16961_RS14595	COG1172	Belongs to the binding-protein-dependent transport system permease family
N16961_RS14600	COG1879	ABC-type sugar transport system periplasmic component
N16961_RS14605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_RS14610	COG1609	Transcriptional regulator
N16961_RS14620	COG3201	nicotinamide mononucleotide transporter
N16961_RS14625	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N16961_RS14635	COG0584	glycerophosphoryl diester phosphodiesterase
N16961_RS14640	COG2271	Major facilitator Superfamily
N16961_RS14680	COG0579	oxidoreductase
N16961_RS14690	COG0242	peptide deformylase activity
N16961_RS14700	COG1320	monovalent cation:proton antiporter activity
N16961_RS14705	COG2212	antiporter activity
N16961_RS14710	COG1863	multisubunit Na H antiporter MnhE subunit
N16961_RS14715	COG0651	ATP synthesis coupled electron transport
N16961_RS14720	COG1006	Multisubunit Na H antiporter MnhC subunit
N16961_RS14725	COG2111	Na H antiporter
N16961_RS14725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N16961_RS14735	COG0589	response to stress
N16961_RS14740	COG0814	amino acid
N16961_RS14755	COG3530	Putative quorum-sensing-regulated virulence factor
N16961_RS14765	COG5001	Diguanylate cyclase
N16961_RS14765	COG5002	protein histidine kinase activity
N16961_RS14770	COG1278	Cold shock
N16961_RS14785	COG2304	oxidoreductase activity
N16961_RS14805	COG0714	Associated with various cellular activities
N16961_RS14810	COG0840	transmembrane signaling receptor activity
N16961_RS14825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N16961_RS14830	COG2195	Cleaves the N-terminal amino acid of tripeptides
N16961_RS14840	COG3604	Transcriptional regulator
N16961_RS14845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N16961_RS14845	COG1017	nitric oxide dioxygenase activity
N16961_RS14850	COG1278	Cold shock
N16961_RS14855	COG3036	rescue of stalled ribosome
N16961_RS14880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N16961_RS14880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N16961_RS14885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N16961_RS14895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N16961_RS14910	COG0516	GMP reductase activity
N16961_RS14950	COG0513	Belongs to the DEAD box helicase family
N16961_RS14955	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N16961_RS14960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N16961_RS14965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N16961_RS14975	COG0784	Response regulator, receiver
N16961_RS14975	COG3437	response regulator, receiver
N16961_RS14980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_RS14980	COG4191	Histidine kinase
N16961_RS14990	COG1757	Na H antiporter
N16961_RS14995	COG2814	Major facilitator Superfamily
N16961_RS15005	COG3706	GGDEF domain
N16961_RS15010	COG3240	lipase activity
N16961_RS15020	COG0840	transmembrane signaling receptor activity
N16961_RS15025	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N16961_RS15030	COG5380	lipid catabolic process
N16961_RS15055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_RS15060	COG4605	iron ion homeostasis
N16961_RS15065	COG4604	ABC transporter, ATP-binding protein
N16961_RS15070	COG2207	Transcriptional regulator
N16961_RS15085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N16961_RS15105	COG0745	RESPONSE REGULATOR receiver
N16961_RS15115	COG3623	hexulose-6-phosphate isomerase
N16961_RS15120	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N16961_RS15125	COG0561	phosphatase activity
N16961_RS15155	COG3038	cytochrome b561
N16961_RS15160	COG0366	Alpha amylase catalytic
N16961_RS15185	COG0745	RESPONSE REGULATOR receiver
N16961_RS15190	COG5002	protein histidine kinase activity
N16961_RS15215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N16961_RS15230	COG2814	Major facilitator Superfamily
N16961_RS15245	COG1686	Belongs to the peptidase S11 family
N16961_RS15275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N16961_RS15275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N16961_RS15280	COG0509	glycine decarboxylation via glycine cleavage system
N16961_RS15285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N16961_RS15295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N16961_RS15305	COG3039	Transposase
N16961_RS15340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N16961_RS15345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N16961_RS15435	COG1028	Short-chain dehydrogenase reductase Sdr
N16961_RS15475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N16961_RS15505	COG0494	nUDIX hydrolase
N16961_RS15530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_RS15535	COG3040	lipid binding
N16961_RS15570	COG3041	Addiction module toxin RelE StbE family
N16961_RS15680	COG1619	proteins homologs of microcin C7 resistance protein MccF
N16961_RS15740	COG0346	lactoylglutathione lyase activity
N16961_RS15760	COG3040	lipid binding
N16961_RS15780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N16961_RS15790	COG1280	lysine exporter protein (LysE YggA)
N16961_RS16020	COG3549	Plasmid maintenance system killer
N16961_RS16025	COG3093	addiction module antidote protein HigA
N16961_RS16050	COG0384	phenazine biosynthesis protein PhzF
N16961_RS16085	COG0346	lactoylglutathione lyase activity
N16961_RS16125	COG3040	lipid binding
N16961_RS16185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_RS16215	COG0384	phenazine biosynthesis protein PhzF
N16961_RS16315	COG1619	proteins homologs of microcin C7 resistance protein MccF
N16961_RS16340	COG3040	lipid binding
N16961_RS16410	COG4977	sequence-specific DNA binding
N16961_RS16520	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
N16961_RS16525	COG2944	sequence-specific DNA binding
N16961_RS16535	COG3039	Transposase
N16961_RS16540	COG0110	maltose O-acetyltransferase activity
N16961_RS16560	COG0346	lactoylglutathione lyase activity
N16961_RS16725	COG0346	lactoylglutathione lyase activity
N16961_RS16750	COG1328	CTP reductase activity
N16961_RS16755	COG0602	queuosine metabolic process
N16961_RS16765	COG4067	protein conserved in archaea
N16961_RS16765	COG0189	ligase activity
N16961_RS16770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_RS16770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N16961_RS16770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N16961_RS16775	COG1105	Belongs to the carbohydrate kinase PfkB family
N16961_RS16780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_RS16780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_RS16785	COG1609	Transcriptional regulator
N16961_RS16790	COG0420	3'-5' exonuclease activity
N16961_RS16795	COG0419	ATPase involved in DNA repair
N16961_RS16800	COG2205	protein histidine kinase activity
N16961_RS16800	COG0784	Response regulator, receiver
N16961_RS16810	COG0156	8-amino-7-oxononanoate synthase activity
N16961_RS16825	COG0523	cobalamin synthesis protein
N16961_RS16840	COG0674	pyruvate-flavodoxin oxidoreductase activity
N16961_RS16840	COG1013	pyruvate-flavodoxin oxidoreductase activity
N16961_RS16840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N16961_RS16840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N16961_RS16845	COG2205	protein histidine kinase activity
N16961_RS16850	COG0745	RESPONSE REGULATOR receiver
N16961_RS16855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N16961_RS16860	COG0586	Pfam SNARE associated Golgi protein
N16961_RS16870	COG2200	EAL domain
N16961_RS16880	COG3038	cytochrome b561
N16961_RS16890	COG2116	formate transmembrane transporter activity
N16961_RS16895	COG0583	DNA-binding transcription factor activity
N16961_RS16905	COG3593	DNA synthesis involved in DNA repair
N16961_RS16910	COG0737	Belongs to the 5'-nucleotidase family
N16961_RS16925	COG2824	Alkylphosphonate utilization operon protein PhnA
N16961_RS16960	COG2199	diguanylate cyclase activity
N16961_RS16980	COG3706	GGDEF domain
N16961_RS16995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N16961_RS17000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N16961_RS17010	COG0745	RESPONSE REGULATOR receiver
N16961_RS17025	COG3140	Belongs to the UPF0181 family
N16961_RS17030	COG0023	Translation Initiation Factor
N16961_RS17050	COG1042	CoA-binding domain protein
N16961_RS17050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_RS17050	COG0045	succinate-CoA ligase (ADP-forming) activity
N16961_RS17055	COG0583	DNA-binding transcription factor activity
N16961_RS17060	COG4771	TonB-dependent receptor
N16961_RS17060	COG1629	transport
N16961_RS17075	COG2050	protein possibly involved in aromatic compounds catabolism
N16961_RS17100	COG0625	glutathione transferase activity
N16961_RS17115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N16961_RS17120	COG4172	Belongs to the ABC transporter superfamily
N16961_RS17125	COG4239	(ABC) transporter, permease
N16961_RS17130	COG4174	ABC transporter (Permease)
N16961_RS17135	COG4166	transmembrane transport
N16961_RS17160	COG3104	oligopeptide transport
N16961_RS17180	COG3842	ATPase activity
N16961_RS17190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N16961_RS17195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N16961_RS17200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N16961_RS17205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N16961_RS17210	COG1011	Hydrolase
N16961_RS17220	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
N16961_RS17225	COG1970	mechanosensitive ion channel activity
N16961_RS17230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N16961_RS17235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_RS17235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N16961_RS17240	COG0302	gtp cyclohydrolase
N16961_RS17250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N16961_RS17260	COG2897	thiosulfate sulfurtransferase activity
N16961_RS17265	COG2390	Transcriptional regulator
N16961_RS17280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N16961_RS17305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N16961_RS17330	COG0583	DNA-binding transcription factor activity
N16961_RS17335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N16961_RS17380	COG0446	pyridine nucleotide-disulphide oxidoreductase
N16961_RS17425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N16961_RS17425	COG1263	PTS System
N16961_RS17430	COG1609	Transcriptional regulator
N16961_RS17435	COG1621	beta-fructofuranosidase activity
N16961_RS17440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_RS17445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N16961_RS17455	COG2885	chlorophyll binding
N16961_RS17460	COG0545	Peptidyl-prolyl cis-trans isomerase
N16961_RS17465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N16961_RS17470	COG0840	transmembrane signaling receptor activity
N16961_RS17480	COG3069	C4-dicarboxylate transmembrane transporter activity
N16961_RS17485	COG1760	l-serine dehydratase
N16961_RS17505	COG1609	Transcriptional regulator
N16961_RS17510	COG2197	response regulator
N16961_RS17515	COG3850	Histidine kinase
N16961_RS17520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N16961_RS17530	COG0243	molybdopterin cofactor binding
N16961_RS17550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N16961_RS17555	COG2197	response regulator
N16961_RS17560	COG3851	Histidine kinase
N16961_RS17565	COG2271	Major facilitator Superfamily
N16961_RS17570	COG1840	ABC-type Fe3 transport system, periplasmic component
N16961_RS17580	COG3842	ATPase activity
N16961_RS17585	COG3243	poly(R)-hydroxyalkanoic acid synthase
N16961_RS17595	COG0183	Belongs to the thiolase family
N16961_RS17605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_RS17610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N16961_RS17630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N16961_RS17640	COG1979	alcohol dehydrogenase
N16961_RS17655	COG4191	Histidine kinase
N16961_RS17665	COG2271	Major facilitator Superfamily
N16961_RS17670	COG0469	pyruvate kinase activity
N16961_RS17675	COG2198	Histidine kinase
N16961_RS17675	COG0784	Response regulator, receiver
N16961_RS17675	COG2205	protein histidine kinase activity
N16961_RS17680	COG1879	ABC-type sugar transport system periplasmic component
N16961_RS17685	COG1803	Methylglyoxal synthase
N16961_RS17690	COG1335	isochorismatase
N16961_RS17695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N16961_RS17710	COG0210	DNA helicase
N16961_RS17715	COG1289	transmembrane transporter activity
N16961_RS17745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N16961_RS17750	COG4149	molybdate abc transporter
N16961_RS17755	COG0725	ABC transporter, periplasmic molybdate-binding protein
N16961_RS17760	COG1492	cobalamin metabolic process
N16961_RS17805	COG0784	Response regulator, receiver
N16961_RS17805	COG5002	protein histidine kinase activity
N16961_RS17810	COG1879	ABC-type sugar transport system periplasmic component
N16961_RS17820	COG2827	Endonuclease containing a URI domain
N16961_RS17835	COG2926	Belongs to the UPF0265 family
N16961_RS17850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N16961_RS17855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N16961_RS17860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N16961_RS17865	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
N16961_RS17870	COG0247	lactate metabolic process
N16961_RS17875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N16961_RS17880	COG3118	belongs to the thioredoxin family
N16961_RS17910	COG0583	DNA-binding transcription factor activity
N16961_RS17915	COG4160	amino acid transport
N16961_RS17920	COG4215	(ABC) transporter
N16961_RS17925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_RS17930	COG1126	abc transporter atp-binding protein
N16961_RS17940	COG2425	protein containing a von Willebrand factor type A (vWA) domain
N16961_RS17950	COG0494	nUDIX hydrolase
N16961_RS17955	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
N16961_RS17965	COG1309	transcriptional regulator
N16961_RS17970	COG0513	Belongs to the DEAD box helicase family
N16961_RS17975	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
N16961_RS17985	COG0814	amino acid
N16961_RS17990	COG0840	transmembrane signaling receptor activity
N16961_RS17995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N16961_RS18005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N16961_RS18015	COG1984	allophanate hydrolase subunit 2
N16961_RS18030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N16961_RS18035	COG4181	ATPase activity
N16961_RS18045	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N16961_RS18050	COG1716	ATPase activity
N16961_RS18050	COG5001	Diguanylate cyclase
N16961_RS18065	COG0484	heat shock protein binding
N16961_RS18105	COG0546	phosphoglycolate phosphatase activity
N16961_RS18120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N16961_RS18125	COG1368	sulfuric ester hydrolase activity
N16961_RS18135	COG0513	Belongs to the DEAD box helicase family
N16961_RS18150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N16961_RS18160	COG3046	protein related to deoxyribodipyrimidine photolyase
N16961_RS18165	COG3397	chitin binding
N16961_RS18170	COG3227	Zinc metalloprotease (Elastase)
N16961_RS18180	COG0010	Belongs to the arginase family
N16961_RS18185	COG1166	arginine decarboxylase activity
N16961_RS18195	COG2239	Acts as a magnesium transporter
N16961_RS18200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N16961_RS18205	COG0459	protein refolding
N16961_RS18215	COG0527	aspartate kinase activity
N16961_RS18220	COG0662	Cupin 2, conserved barrel domain protein
N16961_RS18225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N16961_RS18230	COG0456	acetyltransferase
N16961_RS18240	COG3186	Phenylalanine-4-hydroxylase
N16961_RS18245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N16961_RS18265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N16961_RS18290	COG1253	flavin adenine dinucleotide binding
N16961_RS18295	COG1765	OsmC-like protein
N16961_RS18320	COG0531	amino acid
N16961_RS18335	COG3279	Response regulator of the LytR AlgR family
N16961_RS18340	COG3275	phosphorelay sensor kinase activity
N16961_RS18355	COG0577	efflux transmembrane transporter activity
N16961_RS18355	COG1136	(ABC) transporter
N16961_RS18360	COG1136	(ABC) transporter
N16961_RS18375	COG4989	oxidoreductase activity
N16961_RS18380	COG0366	Alpha amylase catalytic
N16961_RS18390	COG2067	long-chain fatty acid transport protein
N16961_RS18395	COG2267	carboxylic ester hydrolase activity
N16961_RS18405	COG3227	Zinc metalloprotease (Elastase)
N16961_RS18415	COG3047	cAMP biosynthetic process
N16961_RS18425	COG1686	Belongs to the peptidase S11 family
N16961_RS18430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N16961_RS18435	COG1271	oxidase subunit
N16961_RS18440	COG1294	oxidase, subunit
N16961_RS18460	COG3048	D-serine ammonia-lyase activity
N16961_RS18465	COG0583	DNA-binding transcription factor activity
N16961_RS18475	COG0582	viral genome integration into host DNA
N16961_RS18515	COG1063	alcohol dehydrogenase
N16961_RS18545	COG0346	lactoylglutathione lyase activity
N16961_RS18565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N16961_RS18570	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N16961_RS18575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N16961_RS18580	COG0363	glucosamine-6-phosphate deaminase activity
N16961_RS18585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N16961_RS18610	COG1929	Belongs to the glycerate kinase type-1 family
N16961_RS18615	COG2610	gluconate transmembrane transporter activity
N16961_RS18620	COG3835	regulator
N16961_RS18630	COG0748	coenzyme F420 binding
N16961_RS18635	COG3721	Heme iron utilization protein
N16961_RS18645	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N16961_RS18650	COG0811	peptide transport
N16961_RS18655	COG0848	biopolymer transport protein
N16961_RS18660	COG4558	Periplasmic binding protein
N16961_RS18665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N16961_RS18670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N16961_RS18705	COG3217	Mosc domain protein beta barrel domain protein
N16961_RS18705	COG0633	Ferredoxin
N16961_RS18705	COG3217	Mosc domain protein beta barrel domain protein
N16961_RS18705	COG0633	Ferredoxin
N16961_RS18715	COG0418	dihydroorotase activity
N16961_RS18725	COG3152	Membrane
N16961_RS18735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N16961_RS18740	COG2354	Protein conserved in bacteria
N16961_RS18745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N16961_RS18750	COG1278	Cold shock
N16961_RS18780	COG2199	diguanylate cyclase activity
N16961_RS18785	COG1349	DNA-binding transcription factor activity
N16961_RS18800	COG3833	ABC-type maltose transport systems, permease component
N16961_RS18805	COG1175	transmembrane transport
N16961_RS18815	COG3842	ATPase activity
N16961_RS18820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N16961_RS18835	COG0393	Putative heavy-metal-binding
N16961_RS18845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N16961_RS18850	COG0784	Response regulator, receiver
N16961_RS18850	COG0835	chemotaxis
N16961_RS18855	COG1846	Transcriptional regulator
N16961_RS18860	COG3706	GGDEF domain
N16961_RS18900	COG0583	DNA-binding transcription factor activity
N16961_RS18905	COG5001	Diguanylate cyclase
N16961_RS18915	COG1741	Belongs to the pirin family
N16961_RS18920	COG3123	guanosine phosphorylase activity
N16961_RS18930	COG2211	Major facilitator Superfamily
N16961_RS18940	COG0840	transmembrane signaling receptor activity
N16961_RS18945	COG1067	ATP-dependent peptidase activity
N16961_RS18955	COG4172	Belongs to the ABC transporter superfamily
N16961_RS18980	COG0583	DNA-binding transcription factor activity
N16961_RS18985	COG1620	l-lactate permease
N16961_RS19000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N16961_RS19010	COG0840	transmembrane signaling receptor activity
N16961_RS19020	COG0513	Belongs to the DEAD box helicase family
N16961_RS19025	COG0583	DNA-binding transcription factor activity
N16961_RS19035	COG1902	pentaerythritol trinitrate reductase activity
N16961_RS19045	COG1132	(ABC) transporter
N16961_RS19055	COG1902	pentaerythritol trinitrate reductase activity
N16961_RS19065	COG1280	lysine exporter protein (LysE YggA)
N16961_RS19070	COG2207	Transcriptional regulator
N16961_RS19090	COG1846	Transcriptional regulator
N16961_RS19095	COG1764	response to oxidative stress
N16961_RS19100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N16961_RS19105	COG0697	spore germination
N16961_RS19115	COG0700	Nucleoside recognition
N16961_RS19120	COG3366	ferrous iron transmembrane transporter activity
N16961_RS19125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N16961_RS19135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N16961_RS19140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N16961_RS19145	COG2259	Doxx family
N16961_RS19170	COG0363	glucosamine-6-phosphate deaminase activity
N16961_RS19185	COG4580	involved in the transport of maltose and maltodextrins
N16961_RS19200	COG0840	transmembrane signaling receptor activity
N16961_RS19215	COG0840	transmembrane signaling receptor activity
N16961_RS19225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N16961_RS19230	COG1126	abc transporter atp-binding protein
N16961_RS19240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N16961_RS19245	COG4597	amino acid ABC transporter
N16961_RS19250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N16961_RS19260	COG0739	heme binding
N16961_RS19270	COG2213	PTS system mannitol-specific
N16961_RS19270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N16961_RS19275	COG0246	Mannitol dehydrogenase
N16961_RS19280	COG3722	fumarate hydratase activity
N16961_RS19285	COG0673	inositol 2-dehydrogenase activity
N16961_RS19315	COG2910	NAD(P)H-binding
N16961_RS19325	COG0840	transmembrane signaling receptor activity
N16961_RS19335	COG4221	oxidoreductase activity
N16961_RS19345	COG1901	pseudouridine methyltransferase
N16961_RS19360	COG0531	amino acid
N16961_RS19365	COG1982	Orn Lys Arg decarboxylase major
N16961_RS19400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N16961_RS19425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N16961_RS19465	COG0745	RESPONSE REGULATOR receiver
N16961_RS19490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N16961_RS19495	COG0840	transmembrane signaling receptor activity
N16961_RS19500	COG0835	chemotaxis
N16961_RS19505	COG0835	chemotaxis
N16961_RS19510	COG0643	Histidine kinase
N16961_RS19510	COG2198	Histidine kinase
N16961_RS19530	COG0601	transmembrane transport
N16961_RS19535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N16961_RS19545	COG2194	sulfuric ester hydrolase activity
N16961_RS19550	COG0642	Histidine kinase
N16961_RS19585	COG1444	tRNA N-acetyltransferase activity
N16961_RS19590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine