locus-tag	class	description
ASZ85_RS00010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ85_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ASZ85_RS00020	COG0706	membrane insertase activity
ASZ85_RS00030	COG0594	ribonuclease P activity
ASZ85_RS00035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ASZ85_RS00040	COG1126	abc transporter atp-binding protein
ASZ85_RS00055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASZ85_RS00060	COG0592	DNA-directed DNA polymerase activity
ASZ85_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASZ85_RS00070	COG0187	DNA topoisomerase II activity
ASZ85_RS00085	COG0071	Belongs to the small heat shock protein (HSP20) family
ASZ85_RS00090	COG3977	Valine--pyruvate aminotransferase
ASZ85_RS00100	COG0751	glycine-tRNA ligase activity
ASZ85_RS00105	COG0752	glycyl-tRNA synthetase alpha subunit
ASZ85_RS00110	COG2119	membrane
ASZ85_RS00120	COG0425	Belongs to the sulfur carrier protein TusA family
ASZ85_RS00130	COG0604	alcohol dehydrogenase
ASZ85_RS00140	COG0129	dihydroxy-acid dehydratase activity
ASZ85_RS00145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASZ85_RS00160	COG0606	chelatase, subunit chli
ASZ85_RS00220	COG0606	chelatase, subunit chli
ASZ85_RS00225	COG0204	Acyl-transferase
ASZ85_RS00230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASZ85_RS00235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ASZ85_RS00250	COG3084	Protein conserved in bacteria
ASZ85_RS00260	COG4326	sporulation control protein
ASZ85_RS00265	COG1272	protein, Hemolysin III
ASZ85_RS00275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASZ85_RS00280	COG0569	domain protein
ASZ85_RS00285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASZ85_RS00285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASZ85_RS00290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASZ85_RS00295	COG0242	peptide deformylase activity
ASZ85_RS00300	COG1652	LysM domain
ASZ85_RS00305	COG0758	DNA mediated transformation
ASZ85_RS00310	COG2922	Belongs to the Smg family
ASZ85_RS00315	COG0551	DNA topoisomerase type I activity
ASZ85_RS00320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ASZ85_RS00325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ASZ85_RS00330	COG0009	L-threonylcarbamoyladenylate synthase
ASZ85_RS00335	COG0408	coproporphyrinogen oxidase activity
ASZ85_RS00340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASZ85_RS00350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ASZ85_RS00390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASZ85_RS00395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASZ85_RS00405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASZ85_RS00410	COG2104	thiamine diphosphate biosynthetic process
ASZ85_RS00415	COG2022	thiamine diphosphate biosynthetic process
ASZ85_RS00420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASZ85_RS00425	COG0006	proline dipeptidase activity
ASZ85_RS00425	COG0006	proline dipeptidase activity
ASZ85_RS00445	COG1522	sequence-specific DNA binding
ASZ85_RS00450	COG5001	Diguanylate cyclase
ASZ85_RS00450	COG5002	protein histidine kinase activity
ASZ85_RS00470	COG0589	response to stress
ASZ85_RS00480	COG1528	Iron-storage protein
ASZ85_RS00490	COG2081	HI0933 family
ASZ85_RS00500	COG1322	Protein conserved in bacteria
ASZ85_RS00505	COG2226	methyltransferase
ASZ85_RS00520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASZ85_RS00525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASZ85_RS00530	COG0805	protein transport
ASZ85_RS00535	COG1858	cytochrome C peroxidase
ASZ85_RS00540	COG0534	Mate efflux family protein
ASZ85_RS00550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ASZ85_RS00565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ASZ85_RS00570	COG3161	chorismate lyase activity
ASZ85_RS00580	COG1580	Controls the rotational direction of flagella during chemotaxis
ASZ85_RS00595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASZ85_RS00605	COG0084	hydrolase, TatD family'
ASZ85_RS00620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASZ85_RS00620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASZ85_RS00640	COG3078	GTPase activator activity
ASZ85_RS00655	COG3071	HemY protein
ASZ85_RS00660	COG2959	enzyme of heme biosynthesis
ASZ85_RS00665	COG1587	Uroporphyrinogen-III synthase
ASZ85_RS00670	COG0181	hydroxymethylbilane synthase activity
ASZ85_RS00685	COG1965	Belongs to the frataxin family
ASZ85_RS00695	COG0019	diaminopimelate decarboxylase activity
ASZ85_RS00700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ASZ85_RS00710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ASZ85_RS00715	COG1011	Hydrolase
ASZ85_RS00720	COG3287	FIST C domain
ASZ85_RS00720	COG2199	diguanylate cyclase activity
ASZ85_RS00720	COG2200	EAL domain
ASZ85_RS00740	COG0561	phosphatase activity
ASZ85_RS00745	COG2267	carboxylic ester hydrolase activity
ASZ85_RS00750	COG1280	lysine exporter protein (LysE YggA)
ASZ85_RS00755	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ASZ85_RS00760	COG0783	Belongs to the Dps family
ASZ85_RS00800	COG0742	ribosomal rna small subunit methyltransferase
ASZ85_RS00805	COG0552	protein localization to endoplasmic reticulum
ASZ85_RS00810	COG2884	Cell division ATP-binding protein ftsE
ASZ85_RS00815	COG2177	Part of the ABC transporter FtsEX involved in
ASZ85_RS00820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASZ85_RS00825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ85_RS00845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASZ85_RS00850	COG4206	TonB-dependent receptor
ASZ85_RS00855	COG1404	Belongs to the peptidase S8 family
ASZ85_RS00860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASZ85_RS00925	COG0583	DNA-binding transcription factor activity
ASZ85_RS00930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASZ85_RS00935	COG2960	long-chain fatty acid transporting porin activity
ASZ85_RS00940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASZ85_RS00945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ85_RS00950	COG1309	transcriptional regulator
ASZ85_RS01000	COG0747	negative chemotaxis
ASZ85_RS01005	COG0601	transmembrane transport
ASZ85_RS01010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASZ85_RS01020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ85_RS01025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ASZ85_RS01035	COG0210	DNA helicase
ASZ85_RS01040	COG1280	lysine exporter protein (LysE YggA)
ASZ85_RS01055	COG2962	Rard protein
ASZ85_RS01060	COG0514	ATP-dependent DNA helicase (RecQ)
ASZ85_RS01075	COG1132	(ABC) transporter
ASZ85_RS01080	COG4774	siderophore transport
ASZ85_RS01085	COG1120	ATPase activity
ASZ85_RS01110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASZ85_RS01115	COG1263	PTS System
ASZ85_RS01115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ85_RS01120	COG2862	Uncharacterized protein family, UPF0114
ASZ85_RS01125	COG1561	YicC-like family, N-terminal region
ASZ85_RS01130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASZ85_RS01135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASZ85_RS01140	COG1560	Kdo2-lipid A biosynthetic process
ASZ85_RS01145	COG1560	Kdo2-lipid A biosynthetic process
ASZ85_RS01150	COG1309	transcriptional regulator
ASZ85_RS01160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ASZ85_RS01165	COG0840	transmembrane signaling receptor activity
ASZ85_RS01170	COG2003	Belongs to the UPF0758 family
ASZ85_RS01175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASZ85_RS01180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASZ85_RS01190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASZ85_RS01195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASZ85_RS01200	COG0859	PFAM glycosyl transferase family 9
ASZ85_RS01205	COG0463	Glycosyl transferase, family 2
ASZ85_RS01210	COG0859	PFAM glycosyl transferase family 9
ASZ85_RS01215	COG3642	lipopolysaccharide core region biosynthetic process
ASZ85_RS01245	COG1519	Transferase
ASZ85_RS01280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASZ85_RS01285	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ASZ85_RS01285	COG0662	Cupin 2, conserved barrel domain protein
ASZ85_RS01290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASZ85_RS01295	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ASZ85_RS01325	COG0318	PFAM AMP-dependent synthetase and ligase
ASZ85_RS01330	COG1012	belongs to the aldehyde dehydrogenase family
ASZ85_RS01330	COG1454	alcohol dehydrogenase
ASZ85_RS01350	COG5433	transposase activity
ASZ85_RS01380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASZ85_RS01385	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASZ85_RS01390	COG0668	transmembrane transport
ASZ85_RS01395	COG1573	uracil-dna glycosylase
ASZ85_RS01405	COG3068	Protein conserved in bacteria
ASZ85_RS01415	COG1940	carbohydrate kinase activity
ASZ85_RS01420	COG1253	flavin adenine dinucleotide binding
ASZ85_RS01430	COG0776	regulation of translation
ASZ85_RS01440	COG0151	Belongs to the GarS family
ASZ85_RS01455	COG0789	Transcriptional regulator
ASZ85_RS01460	COG3710	Transcriptional regulator
ASZ85_RS01465	COG0531	amino acid
ASZ85_RS01470	COG1982	Orn Lys Arg decarboxylase major
ASZ85_RS01475	COG0840	transmembrane signaling receptor activity
ASZ85_RS01490	COG0800	Aldolase
ASZ85_RS01500	COG3265	gluconokinase activity
ASZ85_RS01505	COG0129	dihydroxy-acid dehydratase activity
ASZ85_RS01510	COG1609	Transcriptional regulator
ASZ85_RS01515	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ASZ85_RS01520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASZ85_RS01530	COG0439	Biotin carboxylase
ASZ85_RS01535	COG0511	ligase activity, forming carbon-carbon bonds
ASZ85_RS01540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ASZ85_RS01545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASZ85_RS01560	COG2814	Major facilitator Superfamily
ASZ85_RS01565	COG2205	protein histidine kinase activity
ASZ85_RS01565	COG0784	Response regulator, receiver
ASZ85_RS01570	COG0248	Ppx GppA phosphatase
ASZ85_RS01575	COG0513	Belongs to the DEAD box helicase family
ASZ85_RS01580	COG3118	belongs to the thioredoxin family
ASZ85_RS01595	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASZ85_RS01645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASZ85_RS01660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASZ85_RS01670	COG1072	(Pantothenic acid kinase))
ASZ85_RS01695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASZ85_RS01700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASZ85_RS01705	COG0250	Participates in transcription elongation, termination and antitermination
ASZ85_RS01710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASZ85_RS01720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ASZ85_RS01725	COG0222	ribosome binding
ASZ85_RS01730	COG0085	RNA polymerase activity
ASZ85_RS01735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASZ85_RS01740	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ASZ85_RS01745	COG2816	NAD+ diphosphatase activity
ASZ85_RS01750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASZ85_RS01765	COG4942	peptidase
ASZ85_RS01770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ASZ85_RS01780	COG0471	metal ion transport
ASZ85_RS01785	COG0688	phosphatidylethanolamine metabolic process
ASZ85_RS01790	COG1162	GTPase activity
ASZ85_RS01795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ASZ85_RS01840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ASZ85_RS01845	COG0802	atpase or kinase
ASZ85_RS01855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ASZ85_RS01860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASZ85_RS01865	COG1923	regulation of RNA biosynthetic process
ASZ85_RS01870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASZ85_RS01875	COG0330	HflC and HflK could
ASZ85_RS01880	COG0330	HflC and HflK could
ASZ85_RS01885	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ASZ85_RS01890	COG2900	Belongs to the SlyX family
ASZ85_RS01900	COG0545	Peptidyl-prolyl cis-trans isomerase
ASZ85_RS01905	COG2964	Protein conserved in bacteria
ASZ85_RS01910	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ASZ85_RS01915	COG2923	Belongs to the DsrF TusC family
ASZ85_RS01930	COG0049	tRNA binding
ASZ85_RS01935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ85_RS01940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASZ85_RS01945	COG2906	2 iron, 2 sulfur cluster binding
ASZ85_RS01955	COG0360	Binds together with S18 to 16S ribosomal RNA
ASZ85_RS01960	COG2965	DNA replication, synthesis of RNA primer
ASZ85_RS01965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASZ85_RS01970	COG0359	binds to the 23S rRNA
ASZ85_RS01985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASZ85_RS01990	COG0432	Pfam Uncharacterised protein family UPF0047
ASZ85_RS02010	COG0735	belongs to the Fur family
ASZ85_RS02015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASZ85_RS02040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ85_RS02050	COG0175	sulfate reduction
ASZ85_RS02090	COG1410	methionine synthase
ASZ85_RS02090	COG0646	methionine synthase
ASZ85_RS02095	COG0527	aspartate kinase activity
ASZ85_RS02100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASZ85_RS02110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASZ85_RS02125	COG0629	single-stranded DNA binding
ASZ85_RS02130	COG2199	diguanylate cyclase activity
ASZ85_RS02130	COG2200	EAL domain
ASZ85_RS02155	COG3409	Peptidoglycan-binding domain 1 protein
ASZ85_RS02155	COG3267	Type II secretory pathway component ExeA
ASZ85_RS02170	COG1459	type II secretion system
ASZ85_RS02180	COG2165	general secretion pathway protein
ASZ85_RS02185	COG2165	general secretion pathway protein
ASZ85_RS02215	COG1077	Cell shape determining protein MreB Mrl
ASZ85_RS02220	COG1792	Involved in formation and maintenance of cell shape
ASZ85_RS02225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ASZ85_RS02230	COG0424	maF-like protein
ASZ85_RS02240	COG3164	Protein of unknown function
ASZ85_RS02245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASZ85_RS02250	COG0312	modulator of DNA gyrase
ASZ85_RS02255	COG2235	arginine
ASZ85_RS02275	COG0589	response to stress
ASZ85_RS02285	COG2358	TRAP transporter, solute receptor (TAXI family
ASZ85_RS02295	COG1438	arginine binding
ASZ85_RS02300	COG0039	L-malate dehydrogenase activity
ASZ85_RS02305	COG0531	amino acid
ASZ85_RS02310	COG0142	geranyltranstransferase activity
ASZ85_RS02315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASZ85_RS02320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASZ85_RS02325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASZ85_RS02330	COG2966	Psort location CytoplasmicMembrane, score
ASZ85_RS02335	COG3610	response to peptide
ASZ85_RS02345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASZ85_RS02350	COG2967	ApaG domain
ASZ85_RS02355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASZ85_RS02360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ASZ85_RS02365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASZ85_RS02370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ASZ85_RS02375	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ASZ85_RS02405	COG0840	transmembrane signaling receptor activity
ASZ85_RS02430	COG0741	lytic transglycosylase activity
ASZ85_RS02435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ASZ85_RS02440	COG1194	a g-specific adenine glycosylase
ASZ85_RS02450	COG2066	Belongs to the glutaminase family
ASZ85_RS02455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASZ85_RS02460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASZ85_RS02475	COG0762	integral membrane protein
ASZ85_RS02480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASZ85_RS02485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ASZ85_RS02505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASZ85_RS02510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ASZ85_RS02515	COG1678	Uncharacterized ACR, COG1678
ASZ85_RS02520	COG0189	ligase activity
ASZ85_RS02525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ASZ85_RS02530	COG2356	endonuclease I
ASZ85_RS02540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASZ85_RS02550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ASZ85_RS02555	COG0583	DNA-binding transcription factor activity
ASZ85_RS02560	COG4771	TonB-dependent receptor
ASZ85_RS02565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASZ85_RS02570	COG0126	phosphoglycerate kinase activity
ASZ85_RS02575	COG0191	fructose-bisphosphate aldolase activity
ASZ85_RS02585	COG0668	transmembrane transport
ASZ85_RS02590	COG1279	arginine transmembrane transporter activity
ASZ85_RS02610	COG1349	DNA-binding transcription factor activity
ASZ85_RS02615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASZ85_RS02620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ASZ85_RS02640	COG0358	DNA primase activity
ASZ85_RS02645	COG1610	YqeY-like protein
ASZ85_RS02650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ASZ85_RS02655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASZ85_RS02665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ASZ85_RS02675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASZ85_RS02680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASZ85_RS02685	COG1968	undecaprenyl-diphosphatase activity
ASZ85_RS02690	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ASZ85_RS02695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASZ85_RS02700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ASZ85_RS02705	COG0585	pseudouridine synthase activity
ASZ85_RS02710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ASZ85_RS02715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASZ85_RS02725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASZ85_RS02730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ASZ85_RS02750	COG4208	sulfate ABC transporter
ASZ85_RS02755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ASZ85_RS02765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ASZ85_RS02775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASZ85_RS02780	COG0527	aspartate kinase activity
ASZ85_RS02785	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ASZ85_RS02830	COG3630	sodium ion export across plasma membrane
ASZ85_RS02835	COG5016	pyruvate
ASZ85_RS02835	COG0511	ligase activity, forming carbon-carbon bonds
ASZ85_RS02840	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ASZ85_RS02850	COG1238	metal cluster binding
ASZ85_RS02855	COG0612	Peptidase, M16
ASZ85_RS02860	COG2918	glutathione biosynthetic process
ASZ85_RS02865	COG1854	S-ribosylhomocysteine lyase activity
ASZ85_RS02870	COG4536	flavin adenine dinucleotide binding
ASZ85_RS02875	COG4137	Cytochrome C assembly protein
ASZ85_RS02880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASZ85_RS02885	COG0228	four-way junction DNA binding
ASZ85_RS02890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASZ85_RS02895	COG0336	Belongs to the RNA methyltransferase TrmD family
ASZ85_RS02900	COG0335	large ribosomal subunit rRNA binding
ASZ85_RS02905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASZ85_RS02910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASZ85_RS02920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ASZ85_RS02930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASZ85_RS02935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASZ85_RS02940	COG0723	plastoquinol--plastocyanin reductase activity
ASZ85_RS02945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASZ85_RS02950	COG2857	Cytochrome c1
ASZ85_RS02955	COG0625	glutathione transferase activity
ASZ85_RS02960	COG2969	positive regulation of protein catabolic process
ASZ85_RS02965	COG2823	Periplasmic or secreted lipoprotein
ASZ85_RS02970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASZ85_RS02975	COG0792	nuclease activity
ASZ85_RS02980	COG3107	peptidoglycan biosynthetic process
ASZ85_RS02985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ASZ85_RS03005	COG0288	reversible hydration of carbon dioxide
ASZ85_RS03010	COG0659	secondary active sulfate transmembrane transporter activity
ASZ85_RS03015	COG1131	(ABC) transporter
ASZ85_RS03020	COG0842	Transport permease protein
ASZ85_RS03025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ASZ85_RS03030	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASZ85_RS03035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASZ85_RS03045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASZ85_RS03055	COG1489	DNA binding
ASZ85_RS03065	COG1643	Atp-dependent helicase
ASZ85_RS03070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASZ85_RS03075	COG1752	Esterase of the alpha-beta hydrolase superfamily
ASZ85_RS03080	COG1049	propionate catabolic process, 2-methylcitrate cycle
ASZ85_RS03085	COG3112	Uncharacterised protein family (UPF0231)
ASZ85_RS03090	COG0347	Belongs to the P(II) protein family
ASZ85_RS03095	COG0004	ammonium transporteR
ASZ85_RS03100	COG1840	ABC-type Fe3 transport system, periplasmic component
ASZ85_RS03110	COG3842	ATPase activity
ASZ85_RS03130	COG2971	BadF BadG BcrA BcrD
ASZ85_RS03140	COG4608	Belongs to the ABC transporter superfamily
ASZ85_RS03145	COG0444	Belongs to the ABC transporter superfamily
ASZ85_RS03150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASZ85_RS03155	COG0601	transmembrane transport
ASZ85_RS03160	COG0747	negative chemotaxis
ASZ85_RS03170	COG2205	protein histidine kinase activity
ASZ85_RS03170	COG0784	Response regulator, receiver
ASZ85_RS03175	COG2813	Specifically methylates the guanine in position
ASZ85_RS03180	COG0628	permease
ASZ85_RS03190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASZ85_RS03195	COG0316	Belongs to the HesB IscA family
ASZ85_RS03210	COG0739	heme binding
ASZ85_RS03215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASZ85_RS03220	COG2027	D-alanyl-D-alanine carboxypeptidase
ASZ85_RS03225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ASZ85_RS03230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASZ85_RS03235	COG1534	Rna-binding protein
ASZ85_RS03240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ASZ85_RS03245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASZ85_RS03250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASZ85_RS03265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASZ85_RS03280	COG0779	Required for maturation of 30S ribosomal subunits
ASZ85_RS03285	COG0195	Participates in both transcription termination and antitermination
ASZ85_RS03290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASZ85_RS03295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASZ85_RS03305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASZ85_RS03330	COG0826	peptidase U32
ASZ85_RS03335	COG0826	peptidase U32
ASZ85_RS03345	COG3154	lipid carrier protein
ASZ85_RS03350	COG3153	acetyltransferase
ASZ85_RS03375	COG0513	Belongs to the DEAD box helicase family
ASZ85_RS03390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASZ85_RS03395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASZ85_RS03400	COG2204	response regulator
ASZ85_RS03410	COG0667	Aldo Keto reductase
ASZ85_RS03420	COG0494	nUDIX hydrolase
ASZ85_RS03425	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ASZ85_RS03430	COG0730	response to heat
ASZ85_RS03435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASZ85_RS03445	COG1283	sodium-dependent phosphate transmembrane transporter activity
ASZ85_RS03450	COG0583	DNA-binding transcription factor activity
ASZ85_RS03455	COG0640	Transcriptional regulator
ASZ85_RS03460	COG0268	Binds directly to 16S ribosomal RNA
ASZ85_RS03465	COG0728	peptidoglycan biosynthetic process
ASZ85_RS03470	COG0196	riboflavin kinase activity
ASZ85_RS03485	COG1047	Peptidyl-prolyl cis-trans
ASZ85_RS03490	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASZ85_RS03495	COG1966	Carbon starvation protein
ASZ85_RS03510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASZ85_RS03515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ASZ85_RS03525	COG3279	Response regulator of the LytR AlgR family
ASZ85_RS03530	COG3275	phosphorelay sensor kinase activity
ASZ85_RS03535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASZ85_RS03540	COG0287	Prephenate dehydrogenase
ASZ85_RS03540	COG1605	Chorismate mutase
ASZ85_RS03550	COG0488	(ABC) transporter
ASZ85_RS03560	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ASZ85_RS03570	COG5001	Diguanylate cyclase
ASZ85_RS03575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ASZ85_RS03580	COG1605	Chorismate mutase
ASZ85_RS03580	COG0077	Prephenate dehydratase
ASZ85_RS03585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASZ85_RS03590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASZ85_RS03595	COG0564	pseudouridine synthase activity
ASZ85_RS03605	COG0542	response to heat
ASZ85_RS03650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASZ85_RS03655	COG0826	peptidase U32
ASZ85_RS03665	COG0745	RESPONSE REGULATOR receiver
ASZ85_RS03670	COG5002	protein histidine kinase activity
ASZ85_RS03680	COG0248	Ppx GppA phosphatase
ASZ85_RS03685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASZ85_RS03695	COG0581	inorganic phosphate transmembrane transporter activity
ASZ85_RS03700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASZ85_RS03715	COG3142	Participates in the control of copper homeostasis
ASZ85_RS03720	COG0450	alkyl hydroperoxide reductase
ASZ85_RS03725	COG0583	DNA-binding transcription factor activity
ASZ85_RS03730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ASZ85_RS03740	COG0517	IMP dehydrogenase activity
ASZ85_RS03760	COG1862	Preprotein translocase
ASZ85_RS03765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASZ85_RS03770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASZ85_RS03775	COG0483	inositol monophosphate 1-phosphatase activity
ASZ85_RS03785	COG1959	2 iron, 2 sulfur cluster binding
ASZ85_RS03790	COG1104	cysteine desulfurase activity
ASZ85_RS03795	COG0822	iron-sulfur transferase activity
ASZ85_RS03805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ASZ85_RS03810	COG0443	Heat shock 70 kDa protein
ASZ85_RS03815	COG0633	Ferredoxin
ASZ85_RS03820	COG2975	iron-sulfur cluster assembly
ASZ85_RS03825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASZ85_RS03830	COG0105	UTP biosynthetic process
ASZ85_RS03835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ASZ85_RS03845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASZ85_RS03850	COG0124	histidyl-tRNA synthetase
ASZ85_RS03855	COG2976	Protein conserved in bacteria
ASZ85_RS03860	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASZ85_RS03865	COG1160	GTP binding
ASZ85_RS03880	COG1570	exodeoxyribonuclease VII activity
ASZ85_RS03885	COG0517	IMP dehydrogenase activity
ASZ85_RS03885	COG0516	GMP reductase activity
ASZ85_RS03890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASZ85_RS03890	COG0519	Catalyzes the synthesis of GMP from XMP
ASZ85_RS03900	COG1584	GPR1 FUN34 yaaH family protein
ASZ85_RS03905	COG1535	isochorismatase
ASZ85_RS03905	COG3433	isochorismatase activity
ASZ85_RS03910	COG1021	2,3-dihydroxybenzoate-AMP ligase
ASZ85_RS03915	COG1169	isochorismate synthase
ASZ85_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
ASZ85_RS03930	COG4592	Periplasmic binding protein
ASZ85_RS03935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASZ85_RS03940	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASZ85_RS03945	COG1120	ATPase activity
ASZ85_RS03955	COG0583	DNA-binding transcription factor activity
ASZ85_RS03960	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ASZ85_RS03965	COG1115	amino acid carrier protein
ASZ85_RS03975	COG0583	DNA-binding transcription factor activity
ASZ85_RS03990	COG4565	transcriptional regulatory protein
ASZ85_RS04000	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ASZ85_RS04005	COG5016	pyruvate
ASZ85_RS04005	COG0511	ligase activity, forming carbon-carbon bonds
ASZ85_RS04010	COG3630	sodium ion export across plasma membrane
ASZ85_RS04020	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ASZ85_RS04030	COG2301	Belongs to the HpcH HpaI aldolase family
ASZ85_RS04035	COG3051	citrate lyase alpha subunit
ASZ85_RS04055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASZ85_RS04060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ASZ85_RS04065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ASZ85_RS04130	COG1012	belongs to the aldehyde dehydrogenase family
ASZ85_RS04150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ASZ85_RS04155	COG0840	transmembrane signaling receptor activity
ASZ85_RS04160	COG3710	Transcriptional regulator
ASZ85_RS04170	COG2165	general secretion pathway protein
ASZ85_RS04185	COG4796	Type ii and iii secretion system protein
ASZ85_RS04205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASZ85_RS04210	COG1459	type II secretion system
ASZ85_RS04220	COG2207	Transcriptional regulator
ASZ85_RS04225	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ASZ85_RS04245	COG0739	heme binding
ASZ85_RS04255	COG3064	Membrane
ASZ85_RS04260	COG0582	viral genome integration into host DNA
ASZ85_RS04280	COG0582	viral genome integration into host DNA
ASZ85_RS04290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASZ85_RS04295	COG2867	negative regulation of translational initiation
ASZ85_RS04300	COG2914	Belongs to the UPF0125 (RnfH) family
ASZ85_RS04305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ASZ85_RS04310	COG0497	DNA recombination
ASZ85_RS04315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASZ85_RS04320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASZ85_RS04325	COG0443	Heat shock 70 kDa protein
ASZ85_RS04330	COG0484	heat shock protein binding
ASZ85_RS04365	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ASZ85_RS04380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ASZ85_RS04390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASZ85_RS04390	COG0047	phosphoribosylformylglycinamidine synthase activity
ASZ85_RS04420	COG0442	prolyl-tRNA aminoacylation
ASZ85_RS04425	COG1720	tRNA m6t6A37 methyltransferase activity
ASZ85_RS04430	COG0254	rRNA binding
ASZ85_RS04435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASZ85_RS04440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ASZ85_RS04445	COG1671	Belongs to the UPF0178 family
ASZ85_RS04455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASZ85_RS04470	COG3098	single-species biofilm formation
ASZ85_RS04475	COG0564	pseudouridine synthase activity
ASZ85_RS04480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASZ85_RS04485	COG0142	geranyltranstransferase activity
ASZ85_RS04490	COG1722	exodeoxyribonuclease VII activity
ASZ85_RS04495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ASZ85_RS04505	COG0301	tRNA thio-modification
ASZ85_RS04505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASZ85_RS04515	COG0583	DNA-binding transcription factor activity
ASZ85_RS04520	COG2363	Small membrane protein
ASZ85_RS04525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASZ85_RS04530	COG1611	Belongs to the LOG family
ASZ85_RS04545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASZ85_RS04545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ASZ85_RS04555	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ASZ85_RS04560	COG1464	Belongs to the NlpA lipoprotein family
ASZ85_RS04565	COG2011	ABC-type metal ion transport system permease component
ASZ85_RS04570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASZ85_RS04575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASZ85_RS04580	COG1609	Transcriptional regulator
ASZ85_RS04585	COG1263	PTS System
ASZ85_RS04585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ85_RS04590	COG0366	Alpha amylase catalytic
ASZ85_RS04620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASZ85_RS04625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASZ85_RS04630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ASZ85_RS04635	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ASZ85_RS04640	COG0110	maltose O-acetyltransferase activity
ASZ85_RS04660	COG1045	serine acetyltransferase
ASZ85_RS04670	COG0438	transferase activity, transferring glycosyl groups
ASZ85_RS04680	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ASZ85_RS04710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASZ85_RS04720	COG1596	polysaccharide export
ASZ85_RS04745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASZ85_RS04755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASZ85_RS04760	COG0321	lipoyl(octanoyl) transferase activity
ASZ85_RS04765	COG2921	Belongs to the UPF0250 family
ASZ85_RS04770	COG1686	Belongs to the peptidase S11 family
ASZ85_RS04775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASZ85_RS04780	COG0772	Belongs to the SEDS family
ASZ85_RS04785	COG0768	penicillin binding
ASZ85_RS04790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ASZ85_RS04795	COG0799	negative regulation of ribosome biogenesis
ASZ85_RS04800	COG1466	dna polymerase III delta subunit
ASZ85_RS04805	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ASZ85_RS04810	COG0495	leucyl-tRNA aminoacylation
ASZ85_RS04815	COG2888	peptidyl-tyrosine sulfation
ASZ85_RS04820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASZ85_RS04825	COG4535	Mg2 and Co2 transporter CorC
ASZ85_RS04835	COG1702	phosphate starvation-inducible protein PhoH
ASZ85_RS04840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASZ85_RS04845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ85_RS04850	COG2190	(PTS) system
ASZ85_RS04860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ85_RS04870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASZ85_RS04875	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ASZ85_RS04880	COG3115	cell septum assembly
ASZ85_RS04885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASZ85_RS04900	COG0789	Transcriptional regulator
ASZ85_RS04905	COG1585	Membrane protein implicated in regulation of membrane protease activity
ASZ85_RS04910	COG0330	HflC and HflK could
ASZ85_RS04920	COG3118	belongs to the thioredoxin family
ASZ85_RS04925	COG0300	oxidoreductase activity
ASZ85_RS04930	COG1090	epimerase
ASZ85_RS04935	COG0622	Phosphoesterase
ASZ85_RS04950	COG3710	Transcriptional regulator
ASZ85_RS04955	COG0326	Molecular chaperone. Has ATPase activity
ASZ85_RS04960	COG0563	adenylate kinase activity
ASZ85_RS04965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASZ85_RS04980	COG0367	asparagine synthase
ASZ85_RS04985	COG4651	solute:proton antiporter activity
ASZ85_RS04985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ASZ85_RS04990	COG1940	carbohydrate kinase activity
ASZ85_RS04990	COG1846	Transcriptional regulator
ASZ85_RS04995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASZ85_RS05000	COG1263	PTS System
ASZ85_RS05000	COG2190	(PTS) system
ASZ85_RS05000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ85_RS05015	COG0101	tRNA pseudouridine synthase activity
ASZ85_RS05020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ASZ85_RS05025	COG0285	dihydrofolate synthase activity
ASZ85_RS05030	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ASZ85_RS05035	COG1286	toxin biosynthetic process
ASZ85_RS05040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ASZ85_RS05045	COG2056	Na+-H+ antiporter family
ASZ85_RS05050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ASZ85_RS05070	COG0346	lactoylglutathione lyase activity
ASZ85_RS05075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ASZ85_RS05095	COG4656	Part of a membrane complex involved in electron transport
ASZ85_RS05100	COG2878	Part of a membrane complex involved in electron transport
ASZ85_RS05105	COG4657	Part of a membrane complex involved in electron transport
ASZ85_RS05115	COG0556	nucleotide-excision repair
ASZ85_RS05125	COG2204	response regulator
ASZ85_RS05130	COG2198	Histidine kinase
ASZ85_RS05135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ASZ85_RS05140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASZ85_RS05145	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASZ85_RS05150	COG0315	cyclic pyranopterin monophosphate synthase activity
ASZ85_RS05155	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ASZ85_RS05160	COG0314	molybdopterin synthase activity
ASZ85_RS05165	COG2199	diguanylate cyclase activity
ASZ85_RS05170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ASZ85_RS05170	COG0517	IMP dehydrogenase activity
ASZ85_RS05170	COG0617	tRNA 3'-terminal CCA addition
ASZ85_RS05185	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ASZ85_RS05195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ85_RS05195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ85_RS05200	COG0489	protein tyrosine kinase activity
ASZ85_RS05210	COG0572	uridine kinase
ASZ85_RS05215	COG2982	Protein involved in outer membrane biogenesis
ASZ85_RS05220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ASZ85_RS05225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASZ85_RS05235	COG2067	long-chain fatty acid transport protein
ASZ85_RS05255	COG0183	Belongs to the thiolase family
ASZ85_RS05260	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASZ85_RS05260	COG1024	Enoyl-CoA hydratase
ASZ85_RS05265	COG0778	Nitroreductase
ASZ85_RS05270	COG0583	DNA-binding transcription factor activity
ASZ85_RS05275	COG0745	RESPONSE REGULATOR receiver
ASZ85_RS05285	COG2832	Protein of unknown function (DUF454)
ASZ85_RS05290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASZ85_RS05300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASZ85_RS05305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASZ85_RS05315	COG2983	Belongs to the UPF0260 family
ASZ85_RS05320	COG1028	Short-chain dehydrogenase reductase Sdr
ASZ85_RS05325	COG0616	signal peptide processing
ASZ85_RS05335	COG1522	sequence-specific DNA binding
ASZ85_RS05340	COG1946	Acyl-CoA thioesterase
ASZ85_RS05360	COG3706	GGDEF domain
ASZ85_RS05370	COG0640	Transcriptional regulator
ASZ85_RS05375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASZ85_RS05400	COG1881	PFAM PEBP family protein
ASZ85_RS05420	COG0009	L-threonylcarbamoyladenylate synthase
ASZ85_RS05435	COG2201	protein-glutamate methylesterase activity
ASZ85_RS05445	COG5002	protein histidine kinase activity
ASZ85_RS05450	COG4191	Histidine kinase
ASZ85_RS05455	COG5001	Diguanylate cyclase
ASZ85_RS05455	COG3300	MHYT domain
ASZ85_RS05460	COG2204	response regulator
ASZ85_RS05480	COG0601	transmembrane transport
ASZ85_RS05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASZ85_RS05490	COG0444	Belongs to the ABC transporter superfamily
ASZ85_RS05495	COG4608	Belongs to the ABC transporter superfamily
ASZ85_RS05500	COG0435	Glutathione S-transferase
ASZ85_RS05505	COG0280	phosphate acetyltransferase
ASZ85_RS05505	COG0857	belongs to the CobB CobQ family
ASZ85_RS05510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ASZ85_RS05515	COG3092	negative regulation of chromosome organization
ASZ85_RS05520	COG4628	conserved protein (DUF2132)
ASZ85_RS05530	COG4120	Belongs to the binding-protein-dependent transport system permease family
ASZ85_RS05540	COG2203	Gaf domain
ASZ85_RS05540	COG2199	diguanylate cyclase activity
ASZ85_RS05545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ASZ85_RS05555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ASZ85_RS05560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASZ85_RS05565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASZ85_RS05570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASZ85_RS05575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASZ85_RS05580	COG0156	8-amino-7-oxononanoate synthase activity
ASZ85_RS05585	COG2226	methyltransferase
ASZ85_RS05590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ASZ85_RS05610	COG0300	oxidoreductase activity
ASZ85_RS05625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ASZ85_RS05635	COG2268	Band 7 protein
ASZ85_RS05645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASZ85_RS05650	COG2915	High frequency lysogenization protein hflD homolog
ASZ85_RS05655	COG0482	sulfurtransferase activity
ASZ85_RS05660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASZ85_RS05665	COG2916	Histone family protein nucleoid-structuring protein H-NS
ASZ85_RS05670	COG1757	Na H antiporter
ASZ85_RS05675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASZ85_RS05680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASZ85_RS05685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASZ85_RS05690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ASZ85_RS05690	COG0131	Imidazoleglycerol-phosphate dehydratase
ASZ85_RS05695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASZ85_RS05700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASZ85_RS05705	COG0107	imidazoleglycerol-phosphate synthase activity
ASZ85_RS05710	COG0140	phosphoribosyl-ATP diphosphatase activity
ASZ85_RS05710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASZ85_RS05715	COG1187	pseudouridine synthase activity
ASZ85_RS05725	COG1278	Cold shock
ASZ85_RS05730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASZ85_RS05735	COG0542	response to heat
ASZ85_RS05740	COG3273	potassium ion transport
ASZ85_RS05740	COG2985	domain, Protein
ASZ85_RS05745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ASZ85_RS05750	COG1012	belongs to the aldehyde dehydrogenase family
ASZ85_RS05750	COG1454	alcohol dehydrogenase
ASZ85_RS05755	COG1737	Transcriptional regulator
ASZ85_RS05760	COG0076	glutamate decarboxylase activity
ASZ85_RS05770	COG2431	L-lysine efflux transmembrane transporter activity
ASZ85_RS05780	COG3070	regulator of competence-specific genes
ASZ85_RS05795	COG3852	Histidine kinase
ASZ85_RS05805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ASZ85_RS05820	COG4067	protein conserved in archaea
ASZ85_RS05820	COG0189	ligase activity
ASZ85_RS05825	COG0500	methyltransferase
ASZ85_RS05830	COG4106	trans-aconitate 2-methyltransferase activity
ASZ85_RS05835	COG1801	Protein of unknown function DUF72
ASZ85_RS05840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASZ85_RS05845	COG1435	thymidine kinase activity
ASZ85_RS05855	COG0159	tryptophan synthase activity
ASZ85_RS05860	COG0133	tryptophan synthase activity
ASZ85_RS05865	COG0135	phosphoribosylanthranilate isomerase activity
ASZ85_RS05865	COG0134	indole-3-glycerol-phosphate synthase activity
ASZ85_RS05870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASZ85_RS05875	COG0512	Glutamine amidotransferase of anthranilate synthase
ASZ85_RS05880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASZ85_RS05890	COG0613	PHP domain protein
ASZ85_RS05895	COG0009	L-threonylcarbamoyladenylate synthase
ASZ85_RS05900	COG1187	pseudouridine synthase activity
ASZ85_RS05905	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ASZ85_RS05910	COG4988	ABC transporter
ASZ85_RS05915	COG0492	ferredoxin-NADP+ reductase activity
ASZ85_RS05925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASZ85_RS05930	COG3706	GGDEF domain
ASZ85_RS05935	COG2949	membrane
ASZ85_RS05945	COG0281	malic enzyme
ASZ85_RS05955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASZ85_RS05975	COG2885	chlorophyll binding
ASZ85_RS05990	COG0277	FAD linked oxidase domain protein
ASZ85_RS05990	COG0247	lactate metabolic process
ASZ85_RS06010	COG2986	histidine ammonia-lyase
ASZ85_RS06015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ASZ85_RS06020	COG0010	Belongs to the arginase family
ASZ85_RS06025	COG1228	amidohydrolase
ASZ85_RS06040	COG3099	Belongs to the UPF0263 family
ASZ85_RS06045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASZ85_RS06055	COG5001	Diguanylate cyclase
ASZ85_RS06060	COG0417	DNA replication proofreading
ASZ85_RS06065	COG2197	response regulator
ASZ85_RS06070	COG0322	excinuclease ABC activity
ASZ85_RS06110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASZ85_RS06115	COG0072	phenylalanine-tRNA ligase activity
ASZ85_RS06115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ85_RS06120	COG0776	regulation of translation
ASZ85_RS06160	COG1346	cytolysis
ASZ85_RS06165	COG1380	Effector of murein hydrolase LrgA
ASZ85_RS06170	COG2925	Exonuclease
ASZ85_RS06175	COG1823	symporter activity
ASZ85_RS06180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASZ85_RS06190	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASZ85_RS06195	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ASZ85_RS06215	COG4139	cobalamin transport
ASZ85_RS06235	COG0840	transmembrane signaling receptor activity
ASZ85_RS06270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASZ85_RS06275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASZ85_RS06280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASZ85_RS06290	COG1054	Belongs to the UPF0176 family
ASZ85_RS06300	COG2814	Major facilitator Superfamily
ASZ85_RS06310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASZ85_RS06335	COG2989	Protein conserved in bacteria
ASZ85_RS06340	COG3108	Peptidase M15
ASZ85_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASZ85_RS06360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ASZ85_RS06390	COG1846	Transcriptional regulator
ASZ85_RS06395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ASZ85_RS06400	COG0726	polysaccharide deacetylase
ASZ85_RS06405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ASZ85_RS06415	COG1447	Phosphotransferase system cellobiose-specific component IIA
ASZ85_RS06420	COG1486	melibiose metabolic process
ASZ85_RS06430	COG1609	Transcriptional regulator
ASZ85_RS06435	COG2943	transferase activity, transferring hexosyl groups
ASZ85_RS06440	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ASZ85_RS06445	COG0840	transmembrane signaling receptor activity
ASZ85_RS06460	COG1448	Aminotransferase
ASZ85_RS06470	COG3437	response regulator, receiver
ASZ85_RS06470	COG2770	Histidine kinase
ASZ85_RS06475	COG0351	phosphomethylpyrimidine kinase
ASZ85_RS06480	COG0017	Asparaginyl-tRNA synthetase
ASZ85_RS06485	COG0840	transmembrane signaling receptor activity
ASZ85_RS06490	COG0720	synthase
ASZ85_RS06495	COG1760	l-serine dehydratase
ASZ85_RS06500	COG0814	amino acid
ASZ85_RS06505	COG0494	nUDIX hydrolase
ASZ85_RS06510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASZ85_RS06525	COG3106	COG3106 Predicted ATPase
ASZ85_RS06530	COG3768	UPF0283 membrane protein
ASZ85_RS06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ASZ85_RS06555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASZ85_RS06565	COG0471	metal ion transport
ASZ85_RS06570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASZ85_RS06570	COG4191	Histidine kinase
ASZ85_RS06580	COG2990	Protein conserved in bacteria
ASZ85_RS06585	COG3713	MltA-interacting MipA family protein
ASZ85_RS06590	COG2205	protein histidine kinase activity
ASZ85_RS06595	COG0745	RESPONSE REGULATOR receiver
ASZ85_RS06630	COG1129	ABC transporter
ASZ85_RS06670	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ASZ85_RS06675	COG0372	Belongs to the citrate synthase family
ASZ85_RS06705	COG2195	Cleaves the N-terminal amino acid of tripeptides
ASZ85_RS06715	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ASZ85_RS06725	COG0625	glutathione transferase activity
ASZ85_RS06730	COG3437	response regulator, receiver
ASZ85_RS06735	COG4999	Histidine kinase
ASZ85_RS06735	COG2205	protein histidine kinase activity
ASZ85_RS06735	COG3437	response regulator, receiver
ASZ85_RS06735	COG3850	Histidine kinase
ASZ85_RS06750	COG3706	GGDEF domain
ASZ85_RS06755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ASZ85_RS06760	COG1254	Belongs to the acylphosphatase family
ASZ85_RS06765	COG2920	part of a sulfur-relay system
ASZ85_RS06770	COG0670	Belongs to the BI1 family
ASZ85_RS06775	COG1126	abc transporter atp-binding protein
ASZ85_RS06780	COG0765	amino acid transport
ASZ85_RS06785	COG4597	amino acid ABC transporter
ASZ85_RS06790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASZ85_RS06800	COG0561	phosphatase activity
ASZ85_RS06805	COG0602	queuosine metabolic process
ASZ85_RS06810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ASZ85_RS06840	COG3706	GGDEF domain
ASZ85_RS06845	COG0443	Heat shock 70 kDa protein
ASZ85_RS06850	COG0443	Heat shock 70 kDa protein
ASZ85_RS06895	COG1643	Atp-dependent helicase
ASZ85_RS06905	COG0443	Heat shock 70 kDa protein
ASZ85_RS06910	COG0095	Lipoate-protein ligase
ASZ85_RS06920	COG0583	DNA-binding transcription factor activity
ASZ85_RS06925	COG0477	Major facilitator Superfamily
ASZ85_RS06930	COG0415	Belongs to the DNA photolyase family
ASZ85_RS06945	COG0745	RESPONSE REGULATOR receiver
ASZ85_RS06955	COG0643	Histidine kinase
ASZ85_RS06955	COG2198	Histidine kinase
ASZ85_RS06960	COG0643	Histidine kinase
ASZ85_RS06960	COG2198	Histidine kinase
ASZ85_RS06960	COG0784	Response regulator, receiver
ASZ85_RS06965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ASZ85_RS06975	COG2201	protein-glutamate methylesterase activity
ASZ85_RS06980	COG0835	chemotaxis
ASZ85_RS06985	COG0840	transmembrane signaling receptor activity
ASZ85_RS06985	COG3290	protein histidine kinase activity
ASZ85_RS06990	COG0840	transmembrane signaling receptor activity
ASZ85_RS07000	COG0513	Belongs to the DEAD box helicase family
ASZ85_RS07010	COG1538	Outer membrane efflux protein
ASZ85_RS07015	COG1566	PFAM secretion protein HlyD family protein
ASZ85_RS07020	COG2814	Major facilitator Superfamily
ASZ85_RS07030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ASZ85_RS07040	COG3501	Rhs element vgr protein
ASZ85_RS07050	COG3675	Pfam Lipase (class 3)
ASZ85_RS07065	COG1280	lysine exporter protein (LysE YggA)
ASZ85_RS07070	COG1115	amino acid carrier protein
ASZ85_RS07085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ASZ85_RS07095	COG1177	transmembrane transport
ASZ85_RS07105	COG3842	ATPase activity
ASZ85_RS07130	COG0589	response to stress
ASZ85_RS07135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASZ85_RS07150	COG2217	Heavy metal translocating P-type atpase
ASZ85_RS07160	COG2010	Cytochrome c
ASZ85_RS07175	COG3278	Belongs to the heme-copper respiratory oxidase family
ASZ85_RS07190	COG2205	protein histidine kinase activity
ASZ85_RS07190	COG0784	Response regulator, receiver
ASZ85_RS07215	COG2994	toxin metabolic process
ASZ85_RS07220	COG1073	alpha beta
ASZ85_RS07220	COG3064	Membrane
ASZ85_RS07220	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ASZ85_RS07390	COG3120	sequence-specific DNA binding
ASZ85_RS07395	COG1067	ATP-dependent peptidase activity
ASZ85_RS07400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASZ85_RS07415	COG0488	(ABC) transporter
ASZ85_RS07425	COG0116	Belongs to the methyltransferase superfamily
ASZ85_RS07425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ASZ85_RS07435	COG0167	dihydroorotate dehydrogenase activity
ASZ85_RS07450	COG0308	aminopeptidase N
ASZ85_RS07465	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ASZ85_RS07470	COG1956	GAF domain-containing protein
ASZ85_RS07475	COG1132	(ABC) transporter
ASZ85_RS07480	COG2995	paraquat-inducible protein a
ASZ85_RS07485	COG3008	intermembrane lipid transfer
ASZ85_RS07495	COG2996	Protein conserved in bacteria
ASZ85_RS07510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ASZ85_RS07515	COG1666	GTP binding
ASZ85_RS07520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASZ85_RS07535	COG0437	4 iron, 4 sulfur cluster binding
ASZ85_RS07540	COG0243	molybdopterin cofactor binding
ASZ85_RS07540	COG3383	formate dehydrogenase (NAD+) activity
ASZ85_RS07570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ASZ85_RS07575	COG0488	(ABC) transporter
ASZ85_RS07580	COG3852	Histidine kinase
ASZ85_RS07585	COG2204	response regulator
ASZ85_RS07595	COG4662	Binding-protein-dependent transport system inner membrane component
ASZ85_RS07600	COG3842	ATPase activity
ASZ85_RS07605	COG0746	molybdenum cofactor guanylyltransferase activity
ASZ85_RS07640	COG1940	carbohydrate kinase activity
ASZ85_RS07645	COG3148	PFAM DTW domain containing protein
ASZ85_RS07655	COG0840	transmembrane signaling receptor activity
ASZ85_RS07660	COG0791	NLP P60 protein
ASZ85_RS07670	COG3001	Fructosamine kinase
ASZ85_RS07680	COG0534	Mate efflux family protein
ASZ85_RS07690	COG1793	dna ligase
ASZ85_RS07705	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ASZ85_RS07710	COG0848	biopolymer transport protein
ASZ85_RS07715	COG0811	peptide transport
ASZ85_RS07720	COG0811	peptide transport
ASZ85_RS07735	COG1175	transmembrane transport
ASZ85_RS07740	COG0395	ABC-type sugar transport system, permease component
ASZ85_RS07745	COG3842	ATPase activity
ASZ85_RS07750	COG1349	DNA-binding transcription factor activity
ASZ85_RS07755	COG0584	glycerophosphoryl diester phosphodiesterase
ASZ85_RS07760	COG2731	YhcH YjgK YiaL family protein
ASZ85_RS07765	COG0251	oxidation-reduction process
ASZ85_RS07770	COG1609	Transcriptional regulator
ASZ85_RS07775	COG2723	6-phospho-beta-galactosidase activity
ASZ85_RS07785	COG0583	DNA-binding transcription factor activity
ASZ85_RS07805	COG1136	(ABC) transporter
ASZ85_RS07805	COG0577	efflux transmembrane transporter activity
ASZ85_RS07810	COG1136	(ABC) transporter
ASZ85_RS07810	COG0577	efflux transmembrane transporter activity
ASZ85_RS07815	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASZ85_RS07815	COG1136	(ABC) transporter
ASZ85_RS07820	COG1294	oxidase, subunit
ASZ85_RS07825	COG1271	oxidase subunit
ASZ85_RS07870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASZ85_RS07880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASZ85_RS07900	COG0753	catalase activity
ASZ85_RS07915	COG3527	Alpha-acetolactate decarboxylase
ASZ85_RS07930	COG2199	diguanylate cyclase activity
ASZ85_RS07930	COG2200	EAL domain
ASZ85_RS07940	COG2017	converts alpha-aldose to the beta-anomer
ASZ85_RS07945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASZ85_RS07950	COG1085	galactose-1-phosphate uridylyltransferase
ASZ85_RS07995	COG0784	Response regulator, receiver
ASZ85_RS07995	COG0835	chemotaxis
ASZ85_RS08005	COG4565	transcriptional regulatory protein
ASZ85_RS08010	COG3290	protein histidine kinase activity
ASZ85_RS08025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ85_RS08045	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ASZ85_RS08050	COG3063	Type IV pilus biogenesis stability protein PilW
ASZ85_RS08065	COG1451	nucleotide metabolic process
ASZ85_RS08075	COG0583	DNA-binding transcription factor activity
ASZ85_RS08160	COG1538	Outer membrane efflux protein
ASZ85_RS08175	COG1748	Saccharopine dehydrogenase
ASZ85_RS08190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASZ85_RS08200	COG0577	efflux transmembrane transporter activity
ASZ85_RS08205	COG4181	ATPase activity
ASZ85_RS08210	COG0534	Mate efflux family protein
ASZ85_RS08215	COG0702	epimerase
ASZ85_RS08225	COG2814	Major facilitator Superfamily
ASZ85_RS08230	COG1187	pseudouridine synthase activity
ASZ85_RS08235	COG1061	Type III restriction enzyme res subunit
ASZ85_RS08255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASZ85_RS08260	COG5001	Diguanylate cyclase
ASZ85_RS08260	COG4251	negative regulation of phosphorylation
ASZ85_RS08260	COG3706	GGDEF domain
ASZ85_RS08260	COG2203	Gaf domain
ASZ85_RS08275	COG0840	transmembrane signaling receptor activity
ASZ85_RS08305	COG4934	collagen metabolic process
ASZ85_RS08320	COG0784	Response regulator, receiver
ASZ85_RS08320	COG2205	protein histidine kinase activity
ASZ85_RS08325	COG2239	Acts as a magnesium transporter
ASZ85_RS08335	COG0814	amino acid
ASZ85_RS08340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ85_RS08345	COG1131	(ABC) transporter
ASZ85_RS08350	COG0842	Transport permease protein
ASZ85_RS08360	COG3313	Fe-S protein
ASZ85_RS08370	COG4134	Bacterial extracellular solute-binding protein
ASZ85_RS08375	COG4135	transport system, permease component
ASZ85_RS08380	COG4136	ATPase activity
ASZ85_RS08385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASZ85_RS08390	COG0564	pseudouridine synthase activity
ASZ85_RS08395	COG0733	neurotransmitter:sodium symporter activity
ASZ85_RS08410	COG0626	cystathionine gamma-synthase activity
ASZ85_RS08415	COG2818	Glycosylase
ASZ85_RS08430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ85_RS08445	COG1842	Phage shock protein A
ASZ85_RS08450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ASZ85_RS08460	COG4168	peptide transport system, permease
ASZ85_RS08475	COG4172	Belongs to the ABC transporter superfamily
ASZ85_RS08490	COG1227	inorganic diphosphatase activity
ASZ85_RS08510	COG0243	molybdopterin cofactor binding
ASZ85_RS08515	COG3005	denitrification pathway
ASZ85_RS08520	COG4459	periplasmic nitrate reductase
ASZ85_RS08530	COG2116	formate transmembrane transporter activity
ASZ85_RS08545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASZ85_RS08550	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ASZ85_RS08565	COG1607	acyl-coa hydrolase
ASZ85_RS08570	COG2350	Protein conserved in bacteria
ASZ85_RS08580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASZ85_RS08585	COG0583	DNA-binding transcription factor activity
ASZ85_RS08600	COG0612	Peptidase, M16
ASZ85_RS08605	COG5001	Diguanylate cyclase
ASZ85_RS08610	COG1032	radical SAM domain protein
ASZ85_RS08630	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ASZ85_RS08640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASZ85_RS08645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ASZ85_RS08650	COG0745	RESPONSE REGULATOR receiver
ASZ85_RS08665	COG1609	Transcriptional regulator
ASZ85_RS08670	COG3070	regulator of competence-specific genes
ASZ85_RS08690	COG0297	glycogen (starch) synthase activity
ASZ85_RS08695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASZ85_RS08700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASZ85_RS08730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASZ85_RS08740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ASZ85_RS08765	COG1012	belongs to the aldehyde dehydrogenase family
ASZ85_RS08770	COG1309	transcriptional regulator
ASZ85_RS08795	COG0668	transmembrane transport
ASZ85_RS08800	COG2995	paraquat-inducible protein a
ASZ85_RS08805	COG3008	intermembrane lipid transfer
ASZ85_RS08805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ASZ85_RS08815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ASZ85_RS08830	COG0582	viral genome integration into host DNA
ASZ85_RS08840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASZ85_RS08860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASZ85_RS08880	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASZ85_RS08900	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
ASZ85_RS08905	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
ASZ85_RS08910	COG1737	Transcriptional regulator
ASZ85_RS08915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASZ85_RS08920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ASZ85_RS08925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ASZ85_RS08930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ASZ85_RS08945	COG1940	carbohydrate kinase activity
ASZ85_RS08950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASZ85_RS08955	COG4409	exo-alpha-(2->6)-sialidase activity
ASZ85_RS08965	COG2003	Belongs to the UPF0758 family
ASZ85_RS08985	COG3941	tape measure
ASZ85_RS09030	COG0488	(ABC) transporter
ASZ85_RS09115	COG0415	Belongs to the DNA photolyase family
ASZ85_RS09125	COG4628	conserved protein (DUF2132)
ASZ85_RS09130	COG3284	Transcriptional regulator
ASZ85_RS09135	COG1012	belongs to the aldehyde dehydrogenase family
ASZ85_RS09145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ85_RS09150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ85_RS09155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ85_RS09165	COG2207	Transcriptional regulator
ASZ85_RS09170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ85_RS09170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ85_RS09170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASZ85_RS09175	COG1482	cell wall glycoprotein biosynthetic process
ASZ85_RS09185	COG0784	Response regulator, receiver
ASZ85_RS09185	COG5002	protein histidine kinase activity
ASZ85_RS09195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ASZ85_RS09205	COG2885	chlorophyll binding
ASZ85_RS09210	COG0823	Involved in the tonB-independent uptake of proteins
ASZ85_RS09225	COG0811	peptide transport
ASZ85_RS09230	COG0824	Thioesterase
ASZ85_RS09235	COG3790	cyd operon protein YbgE
ASZ85_RS09240	COG4890	Cyd operon protein YbgT
ASZ85_RS09245	COG1294	oxidase, subunit
ASZ85_RS09250	COG1271	oxidase subunit
ASZ85_RS09260	COG0632	four-way junction helicase activity
ASZ85_RS09265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASZ85_RS09270	COG0215	cysteine-tRNA ligase activity
ASZ85_RS09275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASZ85_RS09280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ85_RS09285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ASZ85_RS09290	COG3012	SEC-C Motif Domain Protein
ASZ85_RS09295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ASZ85_RS09300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ASZ85_RS09305	COG1199	ATP-dependent helicase activity
ASZ85_RS09310	COG0730	response to heat
ASZ85_RS09315	COG3923	Primosomal replication protein n
ASZ85_RS09325	COG0840	transmembrane signaling receptor activity
ASZ85_RS09330	COG0708	Exodeoxyribonuclease III
ASZ85_RS09335	COG4160	amino acid transport
ASZ85_RS09360	COG1882	Formate acetyltransferase
ASZ85_RS09370	COG0840	transmembrane signaling receptor activity
ASZ85_RS09375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ASZ85_RS09385	COG3013	Belongs to the UPF0304 family
ASZ85_RS09390	COG2766	serine protein kinase
ASZ85_RS09395	COG2718	Belongs to the UPF0229 family
ASZ85_RS09400	COG2719	SpoVR family
ASZ85_RS09405	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ASZ85_RS09410	COG2835	tetraacyldisaccharide 4'-kinase activity
ASZ85_RS09415	COG1663	tetraacyldisaccharide 4'-kinase activity
ASZ85_RS09420	COG1132	(ABC) transporter
ASZ85_RS09425	COG2333	competence protein COMEC
ASZ85_RS09425	COG0658	competence protein
ASZ85_RS09435	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASZ85_RS09440	COG1136	(ABC) transporter
ASZ85_RS09445	COG4591	ABC-type transport system involved in lipoprotein release permease component
ASZ85_RS09455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ASZ85_RS09475	COG1252	NADH dehydrogenase
ASZ85_RS09480	COG3150	esterase
ASZ85_RS09505	COG0537	adenosine 5'-monophosphoramidase activity
ASZ85_RS09520	COG2186	Transcriptional regulator
ASZ85_RS09525	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASZ85_RS09530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ASZ85_RS09535	COG1674	ftsk spoiiie
ASZ85_RS09545	COG0686	Belongs to the AlaDH PNT family
ASZ85_RS09555	COG0583	DNA-binding transcription factor activity
ASZ85_RS09575	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ASZ85_RS09580	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ASZ85_RS09585	COG0776	regulation of translation
ASZ85_RS09590	COG0539	negative regulation of cytoplasmic translation
ASZ85_RS09595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASZ85_RS09600	COG1555	photosystem II stabilization
ASZ85_RS09605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ASZ85_RS09610	COG0776	regulation of translation
ASZ85_RS09615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ASZ85_RS09620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASZ85_RS09630	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASZ85_RS09640	COG4191	Histidine kinase
ASZ85_RS09650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ASZ85_RS09655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ASZ85_RS09660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ASZ85_RS09665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ASZ85_RS09680	COG3300	MHYT domain
ASZ85_RS09680	COG5001	Diguanylate cyclase
ASZ85_RS09690	COG4589	Belongs to the CDS family
ASZ85_RS09730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASZ85_RS09740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ85_RS09755	COG0243	molybdopterin cofactor binding
ASZ85_RS09760	COG3005	denitrification pathway
ASZ85_RS09765	COG3469	chitinase activity
ASZ85_RS09765	COG3325	Belongs to the glycosyl hydrolase 18 family
ASZ85_RS09770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASZ85_RS09780	COG2951	lytic endotransglycosylase activity
ASZ85_RS09785	COG3100	YcgL domain-containing protein
ASZ85_RS09790	COG0850	regulation of cytokinetic process
ASZ85_RS09795	COG2894	cell division
ASZ85_RS09800	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ASZ85_RS09805	COG3015	lipoprotein NlpE involved in copper resistance
ASZ85_RS09825	COG0477	Major facilitator Superfamily
ASZ85_RS09835	COG0840	transmembrane signaling receptor activity
ASZ85_RS09840	COG1396	sequence-specific DNA binding
ASZ85_RS09845	COG3135	benzoate transporter
ASZ85_RS09865	COG0596	Alpha beta hydrolase
ASZ85_RS09870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ASZ85_RS09875	COG1169	isochorismate synthase
ASZ85_RS09880	COG0436	Aminotransferase
ASZ85_RS09885	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ASZ85_RS09890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ASZ85_RS09910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ASZ85_RS09915	COG0318	PFAM AMP-dependent synthetase and ligase
ASZ85_RS09920	COG0596	Alpha beta hydrolase
ASZ85_RS09935	COG1214	PFAM Peptidase M22, glycoprotease
ASZ85_RS09940	COG1199	ATP-dependent helicase activity
ASZ85_RS09950	COG0788	formyltetrahydrofolate deformylase activity
ASZ85_RS09955	COG1902	pentaerythritol trinitrate reductase activity
ASZ85_RS09955	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASZ85_RS09960	COG0616	signal peptide processing
ASZ85_RS09965	COG0252	asparaginase activity
ASZ85_RS09970	COG3139	Protein of unknown function (DUF1315)
ASZ85_RS09980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASZ85_RS09985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASZ85_RS09990	COG0676	glucose-6-phosphate 1-epimerase activity
ASZ85_RS10010	COG2226	methyltransferase
ASZ85_RS10025	COG0835	chemotaxis
ASZ85_RS10025	COG0784	Response regulator, receiver
ASZ85_RS10030	COG1940	carbohydrate kinase activity
ASZ85_RS10040	COG4667	esterase of the alpha-beta hydrolase superfamily
ASZ85_RS10050	COG0733	neurotransmitter:sodium symporter activity
ASZ85_RS10055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ASZ85_RS10055	COG1263	PTS System
ASZ85_RS10060	COG0084	hydrolase, TatD family'
ASZ85_RS10070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASZ85_RS10075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ASZ85_RS10080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASZ85_RS10085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASZ85_RS10090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASZ85_RS10095	COG1028	Short-chain dehydrogenase reductase Sdr
ASZ85_RS10105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASZ85_RS10110	COG0416	fatty acid biosynthetic process
ASZ85_RS10115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASZ85_RS10120	COG1399	metal-binding, possibly nucleic acid-binding protein
ASZ85_RS10125	COG0424	maF-like protein
ASZ85_RS10130	COG0564	pseudouridine synthase activity
ASZ85_RS10145	COG1530	ribonuclease E activity
ASZ85_RS10155	COG3423	Transcriptional regulator
ASZ85_RS10165	COG2842	Transposition protein
ASZ85_RS10255	COG3772	lysozyme
ASZ85_RS10420	COG0659	secondary active sulfate transmembrane transporter activity
ASZ85_RS10435	COG1454	alcohol dehydrogenase
ASZ85_RS10435	COG1012	belongs to the aldehyde dehydrogenase family
ASZ85_RS10440	COG2095	MarC family integral membrane protein
ASZ85_RS10445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASZ85_RS10450	COG1757	Na H antiporter
ASZ85_RS10460	COG3081	Nucleoid-associated protein
ASZ85_RS10465	COG3082	Protein of unknown function (DUF1414)
ASZ85_RS10470	COG3083	sulfuric ester hydrolase activity
ASZ85_RS10485	COG0123	including yeast histone deacetylase and acetoin utilization protein
ASZ85_RS10490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASZ85_RS10495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ASZ85_RS10515	COG2853	Lipoprotein
ASZ85_RS10525	COG4235	cytochrome complex assembly
ASZ85_RS10525	COG3088	subunit of a heme lyase
ASZ85_RS10530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASZ85_RS10535	COG1138	Cytochrome C-type biogenesis protein
ASZ85_RS10540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ASZ85_RS10550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASZ85_RS10555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASZ85_RS10560	COG4133	protoheme IX ABC transporter activity
ASZ85_RS10570	COG0835	chemotaxis
ASZ85_RS10585	COG0643	Histidine kinase
ASZ85_RS10585	COG2198	Histidine kinase
ASZ85_RS10585	COG0784	Response regulator, receiver
ASZ85_RS10590	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ASZ85_RS10620	COG2062	phosphohistidine phosphatase, SixA
ASZ85_RS10625	COG1025	Belongs to the peptidase M16 family
ASZ85_RS10635	COG0018	arginyl-trna synthetase
ASZ85_RS10655	COG1918	ferrous iron import across plasma membrane
ASZ85_RS10660	COG4977	sequence-specific DNA binding
ASZ85_RS10665	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ASZ85_RS10670	COG1121	(ABC) transporter
ASZ85_RS10675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASZ85_RS10685	COG0045	succinate-CoA ligase (ADP-forming) activity
ASZ85_RS10690	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASZ85_RS10695	COG0567	Dehydrogenase, E1 component
ASZ85_RS10705	COG1053	succinate dehydrogenase
ASZ85_RS10710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ASZ85_RS10715	COG2009	succinate dehydrogenase
ASZ85_RS10720	COG0372	Belongs to the citrate synthase family
ASZ85_RS10725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASZ85_RS10735	COG0033	Phosphoglucomutase
ASZ85_RS10740	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ASZ85_RS10745	COG0596	Alpha beta hydrolase
ASZ85_RS10760	COG1346	cytolysis
ASZ85_RS10770	COG0583	DNA-binding transcription factor activity
ASZ85_RS10780	COG0735	belongs to the Fur family
ASZ85_RS10785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ASZ85_RS10790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASZ85_RS10795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ASZ85_RS10805	COG0431	NADPH-dependent FMN reductase
ASZ85_RS10815	COG3101	peptidyl-lysine hydroxylation
ASZ85_RS10820	COG2860	membrane
ASZ85_RS10825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASZ85_RS10835	COG2890	protein-(glutamine-N5) methyltransferase activity
ASZ85_RS10840	COG2840	Smr protein MutS2
ASZ85_RS10850	COG1684	flagellar biosynthetic protein fliR
ASZ85_RS10855	COG1987	bacterial-type flagellum assembly
ASZ85_RS10880	COG1580	Controls the rotational direction of flagella during chemotaxis
ASZ85_RS10905	COG1317	bacterial-type flagellum organization
ASZ85_RS10910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ASZ85_RS10920	COG1677	Flagellar hook-basal body complex protein FliE
ASZ85_RS10940	COG1516	flagellar protein fliS
ASZ85_RS10950	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ASZ85_RS10955	COG1334	flagellar protein FlaG
ASZ85_RS10960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ85_RS10965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ85_RS10970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ85_RS10975	COG2837	iron assimilation
ASZ85_RS10995	COG1393	Belongs to the ArsC family
ASZ85_RS11005	COG1876	peptidase activity
ASZ85_RS11015	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ASZ85_RS11030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASZ85_RS11050	COG4783	chaperone-mediated protein folding
ASZ85_RS11055	COG1393	Belongs to the ArsC family
ASZ85_RS11075	COG2233	PERMEase
ASZ85_RS11080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASZ85_RS11085	COG0737	Belongs to the 5'-nucleotidase family
ASZ85_RS11090	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ASZ85_RS11095	COG2912	Transglutaminase-like superfamily
ASZ85_RS11105	COG2890	protein-(glutamine-N5) methyltransferase activity
ASZ85_RS11110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASZ85_RS11115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASZ85_RS11120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ASZ85_RS11125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASZ85_RS11130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASZ85_RS11135	COG0193	aminoacyl-tRNA hydrolase activity
ASZ85_RS11140	COG0012	GTP binding
ASZ85_RS11225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ85_RS11230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ASZ85_RS11245	COG3951	Flagellar rod assembly protein muramidase FlgJ
ASZ85_RS11245	COG1705	Flagellar rod assembly protein muramidase FlgJ
ASZ85_RS11250	COG1706	bacterial-type flagellum-dependent cell motility
ASZ85_RS11255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ASZ85_RS11265	COG4787	bacterial-type flagellum-dependent cell motility
ASZ85_RS11270	COG1749	Flagellar hook protein flgE
ASZ85_RS11285	COG1815	bacterial-type flagellum-dependent cell motility
ASZ85_RS11290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ASZ85_RS11295	COG0784	Response regulator, receiver
ASZ85_RS11295	COG0835	chemotaxis
ASZ85_RS11330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ASZ85_RS11330	COG3433	isochorismatase activity
ASZ85_RS11330	COG2226	methyltransferase
ASZ85_RS11335	COG2375	cellular response to nickel ion
ASZ85_RS11340	COG4774	siderophore transport
ASZ85_RS11340	COG1629	transport
ASZ85_RS11360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASZ85_RS11365	COG2217	Heavy metal translocating P-type atpase
ASZ85_RS11365	COG2608	mercury ion transmembrane transporter activity
ASZ85_RS11380	COG3735	TraB family
ASZ85_RS11395	COG2840	Smr protein MutS2
ASZ85_RS11400	COG1187	pseudouridine synthase activity
ASZ85_RS11410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASZ85_RS11415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASZ85_RS11420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ASZ85_RS11425	COG0121	glutamine amidotransferase
ASZ85_RS11430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ASZ85_RS11435	COG1960	acyl-CoA dehydrogenase activity
ASZ85_RS11450	COG0328	RNA-DNA hybrid ribonuclease activity
ASZ85_RS11455	COG2226	methyltransferase
ASZ85_RS11460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASZ85_RS11465	COG1388	LysM domain
ASZ85_RS11465	COG0741	lytic transglycosylase activity
ASZ85_RS11470	COG3021	interspecies interaction between organisms
ASZ85_RS11475	COG0347	Belongs to the P(II) protein family
ASZ85_RS11480	COG3479	Phenolic acid decarboxylase
ASZ85_RS11490	COG0037	tRNA processing
ASZ85_RS11495	COG0825	malonyl-CoA metabolic process
ASZ85_RS11500	COG0587	DNA-directed DNA polymerase activity
ASZ85_RS11505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASZ85_RS11510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ85_RS11515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ85_RS11520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ASZ85_RS11525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ASZ85_RS11530	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ASZ85_RS11540	COG0750	zinc metalloprotease
ASZ85_RS11545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASZ85_RS11550	COG0575	Belongs to the CDS family
ASZ85_RS11555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASZ85_RS11560	COG0233	cytoplasmic translational termination
ASZ85_RS11565	COG0528	UMP kinase activity
ASZ85_RS11570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASZ85_RS11575	COG0052	Belongs to the universal ribosomal protein uS2 family
ASZ85_RS11580	COG0024	Methionine aminopeptidase
ASZ85_RS11585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ASZ85_RS11600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ASZ85_RS11605	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ASZ85_RS11610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASZ85_RS11615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASZ85_RS11630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASZ85_RS11630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASZ85_RS11635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASZ85_RS11640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASZ85_RS11645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASZ85_RS11655	COG1073	alpha beta
ASZ85_RS11660	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASZ85_RS11665	COG2252	PERMEase
ASZ85_RS11670	COG2195	Cleaves the N-terminal amino acid of tripeptides
ASZ85_RS11675	COG0189	ligase activity
ASZ85_RS11675	COG4067	protein conserved in archaea
ASZ85_RS11680	COG0189	ligase activity
ASZ85_RS11690	COG0733	neurotransmitter:sodium symporter activity
ASZ85_RS11695	COG3706	GGDEF domain
ASZ85_RS11715	COG1477	protein flavinylation
ASZ85_RS11720	COG2871	sodium ion transport
ASZ85_RS11725	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ85_RS11730	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ85_RS11735	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ85_RS11740	COG1805	sodium ion transport
ASZ85_RS11745	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ASZ85_RS11750	COG0271	Belongs to the BolA IbaG family
ASZ85_RS11755	COG2813	Specifically methylates the guanine in position
ASZ85_RS11765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ASZ85_RS11770	COG2211	Major facilitator Superfamily
ASZ85_RS11780	COG1595	DNA-templated transcription, initiation
ASZ85_RS11790	COG3248	Nucleoside-binding outer membrane protein
ASZ85_RS11795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASZ85_RS11800	COG0693	protein deglycase activity
ASZ85_RS11805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASZ85_RS11810	COG2166	iron-sulfur cluster assembly
ASZ85_RS11815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ASZ85_RS11820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ASZ85_RS11830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ASZ85_RS11830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASZ85_RS11845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASZ85_RS11850	COG1074	ATP-dependent DNA helicase activity
ASZ85_RS11855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ASZ85_RS11870	COG3141	response to X-ray
ASZ85_RS11875	COG2171	N-acyltransferase activity
ASZ85_RS11885	COG0456	acetyltransferase
ASZ85_RS11890	COG0569	domain protein
ASZ85_RS11890	COG0189	ligase activity
ASZ85_RS11905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASZ85_RS11910	COG1609	Transcriptional regulator
ASZ85_RS11915	COG3250	beta-galactosidase activity
ASZ85_RS11930	COG1022	Amp-dependent synthetase and ligase
ASZ85_RS11935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ85_RS11940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ASZ85_RS11955	COG0560	Phosphoserine phosphatase
ASZ85_RS11965	COG0813	purine-nucleoside phosphorylase activity
ASZ85_RS11970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ASZ85_RS11975	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ASZ85_RS11980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASZ85_RS11990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ASZ85_RS11995	COG0084	hydrolase, TatD family'
ASZ85_RS12000	COG3022	response to hydroperoxide
ASZ85_RS12005	COG1115	amino acid carrier protein
ASZ85_RS12020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASZ85_RS12025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ASZ85_RS12030	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ASZ85_RS12035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASZ85_RS12060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ASZ85_RS12070	COG0745	RESPONSE REGULATOR receiver
ASZ85_RS12075	COG2198	Histidine kinase
ASZ85_RS12075	COG5002	protein histidine kinase activity
ASZ85_RS12075	COG0784	Response regulator, receiver
ASZ85_RS12080	COG4251	negative regulation of phosphorylation
ASZ85_RS12080	COG5001	Diguanylate cyclase
ASZ85_RS12080	COG3706	GGDEF domain
ASZ85_RS12080	COG2203	Gaf domain
ASZ85_RS12085	COG1242	4 iron, 4 sulfur cluster binding
ASZ85_RS12090	COG0067	glutamate synthase
ASZ85_RS12090	COG0069	glutamate synthase activity
ASZ85_RS12090	COG0070	glutamate synthase
ASZ85_RS12100	COG0069	glutamate synthase activity
ASZ85_RS12100	COG0067	glutamate synthase
ASZ85_RS12100	COG0070	glutamate synthase
ASZ85_RS12105	COG0493	'glutamate synthase
ASZ85_RS12115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASZ85_RS12125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASZ85_RS12130	COG2860	membrane
ASZ85_RS12135	COG0583	DNA-binding transcription factor activity
ASZ85_RS12140	COG0730	response to heat
ASZ85_RS12150	COG4172	Belongs to the ABC transporter superfamily
ASZ85_RS12175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASZ85_RS12180	COG0505	Belongs to the CarA family
ASZ85_RS12190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASZ85_RS12195	COG0494	nUDIX hydrolase
ASZ85_RS12205	COG0653	protein targeting
ASZ85_RS12215	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ASZ85_RS12220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASZ85_RS12225	COG0849	cell division
ASZ85_RS12230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ASZ85_RS12235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASZ85_RS12245	COG0772	Belongs to the SEDS family
ASZ85_RS12250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASZ85_RS12260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASZ85_RS12265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ASZ85_RS12270	COG0768	penicillin binding
ASZ85_RS12275	COG3116	cell division
ASZ85_RS12290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ85_RS12295	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASZ85_RS12300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASZ85_RS12305	COG2186	Transcriptional regulator
ASZ85_RS12315	COG0737	Belongs to the 5'-nucleotidase family
ASZ85_RS12320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ASZ85_RS12325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASZ85_RS12330	COG4974	Belongs to the 'phage' integrase family
ASZ85_RS12335	COG0716	FMN binding
ASZ85_RS12355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASZ85_RS12360	COG1459	type II secretion system
ASZ85_RS12370	COG0237	dephospho-CoA kinase activity
ASZ85_RS12375	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ASZ85_RS12385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASZ85_RS12390	COG0187	DNA topoisomerase II activity
ASZ85_RS12395	COG3150	esterase
ASZ85_RS12405	COG3151	Protein conserved in bacteria
ASZ85_RS12410	COG0494	nUDIX hydrolase
ASZ85_RS12415	COG1538	Outer membrane efflux protein
ASZ85_RS12425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASZ85_RS12430	COG0840	transmembrane signaling receptor activity
ASZ85_RS12435	COG3025	triphosphatase activity
ASZ85_RS12440	COG1392	Phosphate transport regulator
ASZ85_RS12445	COG0306	phosphate transporter
ASZ85_RS12450	COG4991	sh3 domain protein
ASZ85_RS12460	COG3409	Peptidoglycan-binding domain 1 protein
ASZ85_RS12460	COG3267	Type II secretory pathway component ExeA
ASZ85_RS12470	COG0148	phosphopyruvate hydratase activity
ASZ85_RS12475	COG0504	CTP synthase activity
ASZ85_RS12480	COG3956	TIGRFAM MazG family protein
ASZ85_RS12485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASZ85_RS12500	COG5001	Diguanylate cyclase
ASZ85_RS12520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ASZ85_RS12525	COG1381	Involved in DNA repair and RecF pathway recombination
ASZ85_RS12530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASZ85_RS12545	COG0481	GTPase activity
ASZ85_RS12550	COG3086	response to oxidative stress
ASZ85_RS12565	COG1595	DNA-templated transcription, initiation
ASZ85_RS12575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASZ85_RS12585	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ASZ85_RS12600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ85_RS12605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ85_RS12610	COG3079	Belongs to the UPF0149 family
ASZ85_RS12615	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ASZ85_RS12625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ASZ85_RS12630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ASZ85_RS12635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASZ85_RS12640	COG0440	acetolactate synthase activity
ASZ85_RS12645	COG0028	Belongs to the TPP enzyme family
ASZ85_RS12650	COG1022	Amp-dependent synthetase and ligase
ASZ85_RS12655	COG0583	DNA-binding transcription factor activity
ASZ85_RS12680	COG0473	3-isopropylmalate dehydrogenase activity
ASZ85_RS12685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASZ85_RS12690	COG0066	3-isopropylmalate dehydratase activity
ASZ85_RS12735	COG3437	response regulator, receiver
ASZ85_RS12750	COG0795	lipopolysaccharide-transporting ATPase activity
ASZ85_RS12755	COG0795	lipopolysaccharide-transporting ATPase activity
ASZ85_RS12760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASZ85_RS12765	COG2927	DNA polymerase III (CHI subunit)
ASZ85_RS12770	COG0525	valine-tRNA ligase activity
ASZ85_RS12775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASZ85_RS12780	COG0564	pseudouridine synthase activity
ASZ85_RS12795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASZ85_RS12805	COG0540	Belongs to the ATCase OTCase family
ASZ85_RS12815	COG0251	oxidation-reduction process
ASZ85_RS12825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASZ85_RS12830	COG5007	Belongs to the BolA IbaG family
ASZ85_RS12840	COG2854	intermembrane phospholipid transfer
ASZ85_RS12845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ASZ85_RS12850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ASZ85_RS12855	COG1127	ABC transporter
ASZ85_RS12870	COG0517	IMP dehydrogenase activity
ASZ85_RS12870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASZ85_RS12885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ASZ85_RS12890	COG1137	ATPase activity
ASZ85_RS12900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASZ85_RS12905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ85_RS12910	COG1660	Displays ATPase and GTPase activities
ASZ85_RS12915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASZ85_RS12920	COG2239	Acts as a magnesium transporter
ASZ85_RS12925	COG0312	modulator of DNA gyrase
ASZ85_RS12930	COG3028	Belongs to the UPF0307 family
ASZ85_RS12935	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ASZ85_RS12940	COG1178	ABC-type Fe3 transport system permease component
ASZ85_RS12950	COG0163	prenyltransferase activity
ASZ85_RS12955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASZ85_RS12970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ASZ85_RS12975	COG2105	PFAM AIG2 family protein
ASZ85_RS12985	COG0729	surface antigen
ASZ85_RS12990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASZ85_RS12995	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ASZ85_RS13010	COG1136	(ABC) transporter
ASZ85_RS13030	COG0529	Catalyzes the synthesis of activated sulfate
ASZ85_RS13045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASZ85_RS13045	COG1648	precorrin-2 dehydrogenase activity
ASZ85_RS13050	COG0737	Belongs to the 5'-nucleotidase family
ASZ85_RS13060	COG0513	Belongs to the DEAD box helicase family
ASZ85_RS13065	COG2153	protein acetylation
ASZ85_RS13070	COG0697	spore germination
ASZ85_RS13075	COG3266	domain, Protein
ASZ85_RS13075	COG3061	Opacity-associated protein A
ASZ85_RS13080	COG0545	Peptidyl-prolyl cis-trans isomerase
ASZ85_RS13090	COG0203	ribosomal protein L17
ASZ85_RS13095	COG0202	RNA polymerase activity
ASZ85_RS13100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASZ85_RS13105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASZ85_RS13110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASZ85_RS13115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASZ85_RS13120	COG0201	protein transport
ASZ85_RS13130	COG1841	ribosomal large subunit assembly
ASZ85_RS13135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASZ85_RS13140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASZ85_RS13150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASZ85_RS13155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASZ85_RS13160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASZ85_RS13165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASZ85_RS13170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASZ85_RS13175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASZ85_RS13180	COG0255	Belongs to the universal ribosomal protein uL29 family
ASZ85_RS13185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASZ85_RS13190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASZ85_RS13195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASZ85_RS13200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASZ85_RS13205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASZ85_RS13210	COG0089	rRNA binding
ASZ85_RS13215	COG0088	Forms part of the polypeptide exit tunnel
ASZ85_RS13220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASZ85_RS13225	COG0051	transcription antitermination factor activity, RNA binding
ASZ85_RS13230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASZ85_RS13235	COG0557	exoribonuclease II activity
ASZ85_RS13240	COG3083	sulfuric ester hydrolase activity
ASZ85_RS13245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ASZ85_RS13265	COG1047	Peptidyl-prolyl cis-trans
ASZ85_RS13280	COG2249	NAD(P)H dehydrogenase (quinone) activity
ASZ85_RS13285	COG0488	(ABC) transporter
ASZ85_RS13295	COG0429	hydrolase of the alpha beta-hydrolase fold
ASZ85_RS13305	COG3954	Phosphoribulokinase
ASZ85_RS13320	COG1012	belongs to the aldehyde dehydrogenase family
ASZ85_RS13330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASZ85_RS13340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASZ85_RS13355	COG0180	Tryptophanyl-tRNA synthetase
ASZ85_RS13360	COG0546	phosphoglycolate phosphatase activity
ASZ85_RS13365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASZ85_RS13370	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ASZ85_RS13380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASZ85_RS13385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASZ85_RS13415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ASZ85_RS13425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ASZ85_RS13425	COG0678	peroxiredoxin activity
ASZ85_RS13430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASZ85_RS13440	COG0165	Argininosuccinate lyase
ASZ85_RS13450	COG0137	argininosuccinate synthase activity
ASZ85_RS13455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASZ85_RS13460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASZ85_RS13465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASZ85_RS13470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ASZ85_RS13480	COG1045	serine acetyltransferase
ASZ85_RS13485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASZ85_RS13490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ASZ85_RS13495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ASZ85_RS13500	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ASZ85_RS13505	COG1053	succinate dehydrogenase
ASZ85_RS13510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASZ85_RS13515	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ASZ85_RS13525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASZ85_RS13530	COG1509	lysine 2,3-aminomutase activity
ASZ85_RS13540	COG0459	protein refolding
ASZ85_RS13545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASZ85_RS13570	COG0149	triose-phosphate isomerase activity
ASZ85_RS13575	COG0534	Mate efflux family protein
ASZ85_RS13580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ASZ85_RS13585	COG1575	Belongs to the MenA family. Type 1 subfamily
ASZ85_RS13590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ASZ85_RS13595	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ASZ85_RS13600	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASZ85_RS13605	COG1609	Transcriptional regulator
ASZ85_RS13610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ASZ85_RS13615	COG0254	rRNA binding
ASZ85_RS13620	COG0281	malic enzyme
ASZ85_RS13625	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ASZ85_RS13630	COG0626	cystathionine gamma-synthase activity
ASZ85_RS13635	COG0460	homoserine dehydrogenase
ASZ85_RS13635	COG0527	aspartate kinase activity
ASZ85_RS13640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ASZ85_RS13645	COG3074	FtsZ-dependent cytokinesis
ASZ85_RS13650	COG1494	fructose-1,6-bisphosphatase
ASZ85_RS13655	COG0205	6-phosphofructokinase activity
ASZ85_RS13660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ASZ85_RS13670	COG0745	RESPONSE REGULATOR receiver
ASZ85_RS13675	COG2205	protein histidine kinase activity
ASZ85_RS13685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ASZ85_RS13690	COG3030	protein affecting phage T7 exclusion by the F plasmid
ASZ85_RS13695	COG3706	GGDEF domain
ASZ85_RS13700	COG1027	Aspartate ammonia-lyase
ASZ85_RS13720	COG4232	protein-disulfide reductase activity
ASZ85_RS13740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ASZ85_RS13745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ASZ85_RS13750	COG0194	GDP metabolic process
ASZ85_RS13755	COG1758	RNA polymerase activity
ASZ85_RS13760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASZ85_RS13765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ASZ85_RS13770	COG2233	PERMEase
ASZ85_RS13785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASZ85_RS13790	COG2183	response to ionizing radiation
ASZ85_RS13800	COG0596	Alpha beta hydrolase
ASZ85_RS13815	COG1040	competence protein
ASZ85_RS13825	COG0494	nUDIX hydrolase
ASZ85_RS13830	COG1218	3'(2'),5'-bisphosphate nucleotidase
ASZ85_RS13840	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ASZ85_RS13845	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
ASZ85_RS13850	COG3156	type II secretion system protein K
ASZ85_RS13855	COG4795	General secretion pathway protein
ASZ85_RS13860	COG2165	general secretion pathway protein
ASZ85_RS13865	COG2165	general secretion pathway protein
ASZ85_RS13870	COG2165	general secretion pathway protein
ASZ85_RS13875	COG1459	type II secretion system
ASZ85_RS13880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ASZ85_RS13890	COG3031	protein transport across the cell outer membrane
ASZ85_RS13895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ASZ85_RS13900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ASZ85_RS13905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ASZ85_RS13915	COG0456	acetyltransferase
ASZ85_RS13920	COG1490	D-aminoacyl-tRNA deacylase activity
ASZ85_RS13925	COG1295	ribonuclease BN
ASZ85_RS13935	COG1217	gtp-binding protein TYPA
ASZ85_RS13945	COG0174	glutamine synthetase
ASZ85_RS13955	COG3852	Histidine kinase
ASZ85_RS13965	COG3300	MHYT domain
ASZ85_RS13965	COG5001	Diguanylate cyclase
ASZ85_RS13970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASZ85_RS14015	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ASZ85_RS14020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ASZ85_RS14025	COG1739	Uncharacterized protein family UPF0029
ASZ85_RS14035	COG0183	Belongs to the thiolase family
ASZ85_RS14040	COG0583	DNA-binding transcription factor activity
ASZ85_RS14045	COG2814	Major facilitator Superfamily
ASZ85_RS14050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASZ85_RS14055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASZ85_RS14060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASZ85_RS14065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASZ85_RS14070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASZ85_RS14075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASZ85_RS14080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASZ85_RS14090	COG0356	it plays a direct role in the translocation of protons across the membrane
ASZ85_RS14095	COG3312	ion transport
ASZ85_RS14100	COG1475	DNA binding
ASZ85_RS14105	COG1192	Involved in chromosome partitioning
ASZ85_RS14115	COG0445	tRNA wobble uridine modification
ASZ85_RS14130	COG0706	membrane insertase activity
ASZ85_RS14185	COG0752	glycyl-tRNA synthetase alpha subunit
ASZ85_RS14435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASZ85_RS14570	COG0805	protein transport
ASZ85_RS14585	COG0534	Mate efflux family protein
ASZ85_RS14715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ASZ85_RS14900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASZ85_RS14980	COG0339	signal peptide processing
ASZ85_RS14995	COG0210	DNA helicase
ASZ85_RS15035	COG0514	ATP-dependent DNA helicase (RecQ)
ASZ85_RS15045	COG1132	(ABC) transporter
ASZ85_RS15070	COG4774	siderophore transport
ASZ85_RS15330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASZ85_RS15580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASZ85_RS15780	COG0085	RNA polymerase activity
ASZ85_RS15800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASZ85_RS15845	COG2816	NAD+ diphosphatase activity
ASZ85_RS15855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASZ85_RS15950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ASZ85_RS15955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ASZ85_RS16035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASZ85_RS16120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ85_RS16125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ85_RS16130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ85_RS16140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASZ85_RS16160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASZ85_RS16205	COG0305	Participates in initiation and elongation during chromosome replication
ASZ85_RS16240	COG0166	Belongs to the GPI family
ASZ85_RS16305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ85_RS16315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ85_RS16325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ASZ85_RS16445	COG0646	methionine synthase
ASZ85_RS16445	COG1410	methionine synthase
ASZ85_RS16465	COG0646	methionine synthase
ASZ85_RS16465	COG1410	methionine synthase
ASZ85_RS16500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASZ85_RS16755	COG1077	Cell shape determining protein MreB Mrl
ASZ85_RS16770	COG1077	Cell shape determining protein MreB Mrl
ASZ85_RS16785	COG0424	maF-like protein
ASZ85_RS16800	COG1530	ribonuclease E activity
ASZ85_RS16845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ASZ85_RS16865	COG0312	modulator of DNA gyrase
ASZ85_RS16955	COG0531	amino acid
ASZ85_RS16960	COG0531	amino acid
ASZ85_RS17200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASZ85_RS17435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ASZ85_RS17510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ASZ85_RS17565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASZ85_RS17725	COG1643	Atp-dependent helicase
ASZ85_RS17730	COG1643	Atp-dependent helicase
ASZ85_RS17825	COG2971	BadF BadG BcrA BcrD
ASZ85_RS17845	COG4608	Belongs to the ABC transporter superfamily
ASZ85_RS18010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASZ85_RS18030	COG1185	polyribonucleotide nucleotidyltransferase activity
ASZ85_RS18305	COG0564	pseudouridine synthase activity
ASZ85_RS18395	COG0248	Ppx GppA phosphatase
ASZ85_RS18525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASZ85_RS18560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ASZ85_RS18700	COG2015	COG2015, Alkyl sulfatase and related hydrolases
ASZ85_RS18975	COG3064	Membrane
ASZ85_RS19195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ASZ85_RS19280	COG1566	PFAM secretion protein HlyD family protein
ASZ85_RS19290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ASZ85_RS19560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ASZ85_RS19960	COG0183	Belongs to the thiolase family