locus-tag	class	description
GTF73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GTF73_RS00010	COG0592	DNA-directed DNA polymerase activity
GTF73_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTF73_RS00020	COG0187	DNA topoisomerase II activity
GTF73_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
GTF73_RS00035	COG3977	Valine--pyruvate aminotransferase
GTF73_RS00040	COG0751	glycine-tRNA ligase activity
GTF73_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
GTF73_RS00050	COG2119	membrane
GTF73_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
GTF73_RS00070	COG0604	alcohol dehydrogenase
GTF73_RS00080	COG0129	dihydroxy-acid dehydratase activity
GTF73_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTF73_RS00130	COG0204	Acyl-transferase
GTF73_RS00135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTF73_RS00140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTF73_RS00150	COG3084	Protein conserved in bacteria
GTF73_RS00155	COG4326	sporulation control protein
GTF73_RS00160	COG1272	protein, Hemolysin III
GTF73_RS00170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTF73_RS00175	COG0569	domain protein
GTF73_RS00180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTF73_RS00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTF73_RS00185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GTF73_RS00190	COG0242	peptide deformylase activity
GTF73_RS00195	COG1652	LysM domain
GTF73_RS00200	COG0758	DNA mediated transformation
GTF73_RS00205	COG2922	Belongs to the Smg family
GTF73_RS00210	COG0551	DNA topoisomerase type I activity
GTF73_RS00215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GTF73_RS00220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GTF73_RS00225	COG0009	L-threonylcarbamoyladenylate synthase
GTF73_RS00230	COG0408	coproporphyrinogen oxidase activity
GTF73_RS00235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GTF73_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTF73_RS00285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTF73_RS00290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GTF73_RS00300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTF73_RS00305	COG2104	thiamine diphosphate biosynthetic process
GTF73_RS00310	COG2022	thiamine diphosphate biosynthetic process
GTF73_RS00315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTF73_RS00320	COG0006	proline dipeptidase activity
GTF73_RS00320	COG0006	proline dipeptidase activity
GTF73_RS00340	COG1522	sequence-specific DNA binding
GTF73_RS00345	COG5002	protein histidine kinase activity
GTF73_RS00345	COG5001	Diguanylate cyclase
GTF73_RS00365	COG0589	response to stress
GTF73_RS00370	COG1528	Iron-storage protein
GTF73_RS00380	COG2081	HI0933 family
GTF73_RS00390	COG1322	Protein conserved in bacteria
GTF73_RS00395	COG2226	methyltransferase
GTF73_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTF73_RS00415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTF73_RS00420	COG0805	protein transport
GTF73_RS00425	COG1858	cytochrome C peroxidase
GTF73_RS00430	COG0534	Mate efflux family protein
GTF73_RS00440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTF73_RS00450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GTF73_RS00455	COG3161	chorismate lyase activity
GTF73_RS00460	COG1580	Controls the rotational direction of flagella during chemotaxis
GTF73_RS00465	COG0840	transmembrane signaling receptor activity
GTF73_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTF73_RS00480	COG0084	hydrolase, TatD family'
GTF73_RS00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTF73_RS00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTF73_RS00515	COG3078	GTPase activator activity
GTF73_RS00530	COG3071	HemY protein
GTF73_RS00535	COG2959	enzyme of heme biosynthesis
GTF73_RS00540	COG1587	Uroporphyrinogen-III synthase
GTF73_RS00545	COG0181	hydroxymethylbilane synthase activity
GTF73_RS00555	COG1965	Belongs to the frataxin family
GTF73_RS00565	COG0019	diaminopimelate decarboxylase activity
GTF73_RS00570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GTF73_RS00580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GTF73_RS00585	COG1011	Hydrolase
GTF73_RS00590	COG2200	EAL domain
GTF73_RS00590	COG3287	FIST C domain
GTF73_RS00590	COG2199	diguanylate cyclase activity
GTF73_RS00605	COG0561	phosphatase activity
GTF73_RS00610	COG2267	carboxylic ester hydrolase activity
GTF73_RS00615	COG1280	lysine exporter protein (LysE YggA)
GTF73_RS00620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTF73_RS00625	COG0783	Belongs to the Dps family
GTF73_RS00655	COG0742	ribosomal rna small subunit methyltransferase
GTF73_RS00660	COG0552	protein localization to endoplasmic reticulum
GTF73_RS00665	COG2884	Cell division ATP-binding protein ftsE
GTF73_RS00670	COG2177	Part of the ABC transporter FtsEX involved in
GTF73_RS00675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTF73_RS00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF73_RS00695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTF73_RS00700	COG4206	TonB-dependent receptor
GTF73_RS00705	COG1404	Belongs to the peptidase S8 family
GTF73_RS00710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTF73_RS00780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GTF73_RS00785	COG5001	Diguanylate cyclase
GTF73_RS00785	COG3300	MHYT domain
GTF73_RS00795	COG3852	Histidine kinase
GTF73_RS00805	COG0174	glutamine synthetase
GTF73_RS00825	COG1295	ribonuclease BN
GTF73_RS00830	COG1490	D-aminoacyl-tRNA deacylase activity
GTF73_RS00835	COG0456	acetyltransferase
GTF73_RS00845	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GTF73_RS00850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GTF73_RS00855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTF73_RS00860	COG3031	protein transport across the cell outer membrane
GTF73_RS00870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF73_RS00875	COG1459	type II secretion system
GTF73_RS00880	COG2165	general secretion pathway protein
GTF73_RS00885	COG2165	general secretion pathway protein
GTF73_RS00890	COG2165	general secretion pathway protein
GTF73_RS00895	COG4795	General secretion pathway protein
GTF73_RS00900	COG3156	type II secretion system protein K
GTF73_RS00905	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GTF73_RS00910	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GTF73_RS00920	COG1218	3'(2'),5'-bisphosphate nucleotidase
GTF73_RS00925	COG0494	nUDIX hydrolase
GTF73_RS00935	COG1040	competence protein
GTF73_RS00945	COG0596	Alpha beta hydrolase
GTF73_RS00955	COG2183	response to ionizing radiation
GTF73_RS00960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTF73_RS00965	COG0745	RESPONSE REGULATOR receiver
GTF73_RS00975	COG2233	PERMEase
GTF73_RS00980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTF73_RS00985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTF73_RS00990	COG1758	RNA polymerase activity
GTF73_RS00995	COG0194	GDP metabolic process
GTF73_RS01000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GTF73_RS01005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTF73_RS01025	COG4232	protein-disulfide reductase activity
GTF73_RS01035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTF73_RS01040	COG1027	Aspartate ammonia-lyase
GTF73_RS01045	COG3706	GGDEF domain
GTF73_RS01050	COG3030	protein affecting phage T7 exclusion by the F plasmid
GTF73_RS01055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GTF73_RS01065	COG2205	protein histidine kinase activity
GTF73_RS01070	COG0745	RESPONSE REGULATOR receiver
GTF73_RS01080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTF73_RS01085	COG0205	6-phosphofructokinase activity
GTF73_RS01090	COG1494	fructose-1,6-bisphosphatase
GTF73_RS01095	COG3074	FtsZ-dependent cytokinesis
GTF73_RS01100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GTF73_RS01105	COG0460	homoserine dehydrogenase
GTF73_RS01105	COG0527	aspartate kinase activity
GTF73_RS01110	COG0626	cystathionine gamma-synthase activity
GTF73_RS01115	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GTF73_RS01120	COG0281	malic enzyme
GTF73_RS01125	COG0254	rRNA binding
GTF73_RS01130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTF73_RS01135	COG1609	Transcriptional regulator
GTF73_RS01140	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTF73_RS01145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GTF73_RS01150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GTF73_RS01155	COG1575	Belongs to the MenA family. Type 1 subfamily
GTF73_RS01160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTF73_RS01165	COG0534	Mate efflux family protein
GTF73_RS01170	COG0149	triose-phosphate isomerase activity
GTF73_RS01195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTF73_RS01200	COG0459	protein refolding
GTF73_RS01210	COG1509	lysine 2,3-aminomutase activity
GTF73_RS01215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTF73_RS01225	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GTF73_RS01230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GTF73_RS01235	COG1053	succinate dehydrogenase
GTF73_RS01240	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GTF73_RS01245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTF73_RS01250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GTF73_RS01255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GTF73_RS01260	COG1045	serine acetyltransferase
GTF73_RS01270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GTF73_RS01275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTF73_RS01280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GTF73_RS01285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GTF73_RS01290	COG0137	argininosuccinate synthase activity
GTF73_RS01295	COG0165	Argininosuccinate lyase
GTF73_RS01305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF73_RS01310	COG0678	peroxiredoxin activity
GTF73_RS01310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTF73_RS01320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GTF73_RS01350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GTF73_RS01355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GTF73_RS01365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GTF73_RS01370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTF73_RS01375	COG0546	phosphoglycolate phosphatase activity
GTF73_RS01380	COG0180	Tryptophanyl-tRNA synthetase
GTF73_RS01395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTF73_RS01405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTF73_RS01415	COG1012	belongs to the aldehyde dehydrogenase family
GTF73_RS01430	COG3954	Phosphoribulokinase
GTF73_RS01440	COG0429	hydrolase of the alpha beta-hydrolase fold
GTF73_RS01450	COG0488	(ABC) transporter
GTF73_RS01455	COG2249	NAD(P)H dehydrogenase (quinone) activity
GTF73_RS01470	COG1047	Peptidyl-prolyl cis-trans
GTF73_RS01485	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GTF73_RS01490	COG3083	sulfuric ester hydrolase activity
GTF73_RS01495	COG0557	exoribonuclease II activity
GTF73_RS01500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTF73_RS01505	COG0051	transcription antitermination factor activity, RNA binding
GTF73_RS01510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GTF73_RS01515	COG0088	Forms part of the polypeptide exit tunnel
GTF73_RS01520	COG0089	rRNA binding
GTF73_RS01525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GTF73_RS01530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GTF73_RS01535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GTF73_RS01540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GTF73_RS01545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTF73_RS01550	COG0255	Belongs to the universal ribosomal protein uL29 family
GTF73_RS01555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GTF73_RS01560	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GTF73_RS01565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GTF73_RS01570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GTF73_RS01575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GTF73_RS01580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GTF73_RS01590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GTF73_RS01595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GTF73_RS01600	COG1841	ribosomal large subunit assembly
GTF73_RS01610	COG0201	protein transport
GTF73_RS01615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTF73_RS01620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GTF73_RS01625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GTF73_RS01630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GTF73_RS01635	COG0202	RNA polymerase activity
GTF73_RS01640	COG0203	ribosomal protein L17
GTF73_RS01650	COG0545	Peptidyl-prolyl cis-trans isomerase
GTF73_RS01655	COG3061	Opacity-associated protein A
GTF73_RS01655	COG3266	domain, Protein
GTF73_RS01660	COG0697	spore germination
GTF73_RS01665	COG2153	protein acetylation
GTF73_RS01670	COG0513	Belongs to the DEAD box helicase family
GTF73_RS01680	COG0737	Belongs to the 5'-nucleotidase family
GTF73_RS01685	COG1648	precorrin-2 dehydrogenase activity
GTF73_RS01685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTF73_RS01700	COG0529	Catalyzes the synthesis of activated sulfate
GTF73_RS01720	COG1136	(ABC) transporter
GTF73_RS01735	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GTF73_RS01740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF73_RS01745	COG0729	surface antigen
GTF73_RS01755	COG2105	PFAM AIG2 family protein
GTF73_RS01760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GTF73_RS01770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTF73_RS01775	COG0163	prenyltransferase activity
GTF73_RS01785	COG1178	ABC-type Fe3 transport system permease component
GTF73_RS01790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GTF73_RS01795	COG3028	Belongs to the UPF0307 family
GTF73_RS01800	COG0312	modulator of DNA gyrase
GTF73_RS01805	COG2239	Acts as a magnesium transporter
GTF73_RS01810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF73_RS01815	COG1660	Displays ATPase and GTPase activities
GTF73_RS01820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF73_RS01825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTF73_RS01835	COG1137	ATPase activity
GTF73_RS01840	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GTF73_RS01855	COG0517	IMP dehydrogenase activity
GTF73_RS01855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GTF73_RS01865	COG1127	ABC transporter
GTF73_RS01870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GTF73_RS01875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTF73_RS01880	COG2854	intermembrane phospholipid transfer
GTF73_RS01890	COG5007	Belongs to the BolA IbaG family
GTF73_RS01895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTF73_RS01905	COG0251	oxidation-reduction process
GTF73_RS01915	COG0540	Belongs to the ATCase OTCase family
GTF73_RS01925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GTF73_RS01935	COG0564	pseudouridine synthase activity
GTF73_RS01940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTF73_RS01945	COG0525	valine-tRNA ligase activity
GTF73_RS01950	COG2927	DNA polymerase III (CHI subunit)
GTF73_RS01955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTF73_RS01960	COG0795	lipopolysaccharide-transporting ATPase activity
GTF73_RS01965	COG0795	lipopolysaccharide-transporting ATPase activity
GTF73_RS01980	COG3437	response regulator, receiver
GTF73_RS02025	COG0066	3-isopropylmalate dehydratase activity
GTF73_RS02030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GTF73_RS02035	COG0473	3-isopropylmalate dehydrogenase activity
GTF73_RS02060	COG0583	DNA-binding transcription factor activity
GTF73_RS02065	COG1022	Amp-dependent synthetase and ligase
GTF73_RS02070	COG0028	Belongs to the TPP enzyme family
GTF73_RS02075	COG0440	acetolactate synthase activity
GTF73_RS02080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTF73_RS02085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GTF73_RS02090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTF73_RS02100	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GTF73_RS02105	COG3079	Belongs to the UPF0149 family
GTF73_RS02110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF73_RS02115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF73_RS02130	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GTF73_RS02145	COG1595	DNA-templated transcription, initiation
GTF73_RS02160	COG3086	response to oxidative stress
GTF73_RS02165	COG0481	GTPase activity
GTF73_RS02180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GTF73_RS02185	COG1381	Involved in DNA repair and RecF pathway recombination
GTF73_RS02190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GTF73_RS02210	COG5001	Diguanylate cyclase
GTF73_RS02225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTF73_RS02230	COG3956	TIGRFAM MazG family protein
GTF73_RS02235	COG0504	CTP synthase activity
GTF73_RS02240	COG0148	phosphopyruvate hydratase activity
GTF73_RS02250	COG3409	Peptidoglycan-binding domain 1 protein
GTF73_RS02250	COG3267	Type II secretory pathway component ExeA
GTF73_RS02260	COG4991	sh3 domain protein
GTF73_RS02265	COG0306	phosphate transporter
GTF73_RS02270	COG1392	Phosphate transport regulator
GTF73_RS02275	COG3025	triphosphatase activity
GTF73_RS02280	COG0840	transmembrane signaling receptor activity
GTF73_RS02285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GTF73_RS02295	COG1538	Outer membrane efflux protein
GTF73_RS02300	COG0494	nUDIX hydrolase
GTF73_RS02305	COG3151	Protein conserved in bacteria
GTF73_RS02315	COG3150	esterase
GTF73_RS02320	COG0187	DNA topoisomerase II activity
GTF73_RS02325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTF73_RS02335	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GTF73_RS02340	COG0237	dephospho-CoA kinase activity
GTF73_RS02350	COG1459	type II secretion system
GTF73_RS02355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF73_RS02375	COG0716	FMN binding
GTF73_RS02380	COG4974	Belongs to the 'phage' integrase family
GTF73_RS02385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTF73_RS02390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTF73_RS02395	COG0737	Belongs to the 5'-nucleotidase family
GTF73_RS02400	COG2186	Transcriptional regulator
GTF73_RS02405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GTF73_RS02410	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTF73_RS02415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF73_RS02430	COG3116	cell division
GTF73_RS02435	COG0768	penicillin binding
GTF73_RS02440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTF73_RS02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTF73_RS02455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTF73_RS02460	COG0772	Belongs to the SEDS family
GTF73_RS02470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTF73_RS02475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GTF73_RS02480	COG0849	cell division
GTF73_RS02485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTF73_RS02490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GTF73_RS02500	COG0653	protein targeting
GTF73_RS02505	COG0494	nUDIX hydrolase
GTF73_RS02510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GTF73_RS02520	COG0505	Belongs to the CarA family
GTF73_RS02525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTF73_RS02540	COG4172	Belongs to the ABC transporter superfamily
GTF73_RS02550	COG0730	response to heat
GTF73_RS02555	COG0583	DNA-binding transcription factor activity
GTF73_RS02560	COG2860	membrane
GTF73_RS02565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTF73_RS02575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GTF73_RS02585	COG0493	'glutamate synthase
GTF73_RS02590	COG0069	glutamate synthase activity
GTF73_RS02590	COG0067	glutamate synthase
GTF73_RS02590	COG0070	glutamate synthase
GTF73_RS02600	COG0070	glutamate synthase
GTF73_RS02600	COG0069	glutamate synthase activity
GTF73_RS02600	COG0067	glutamate synthase
GTF73_RS02605	COG1242	4 iron, 4 sulfur cluster binding
GTF73_RS02610	COG5001	Diguanylate cyclase
GTF73_RS02610	COG4251	negative regulation of phosphorylation
GTF73_RS02610	COG3706	GGDEF domain
GTF73_RS02610	COG2203	Gaf domain
GTF73_RS02615	COG2198	Histidine kinase
GTF73_RS02615	COG5002	protein histidine kinase activity
GTF73_RS02615	COG0784	Response regulator, receiver
GTF73_RS02620	COG0745	RESPONSE REGULATOR receiver
GTF73_RS02630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTF73_RS02655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GTF73_RS02660	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GTF73_RS02665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GTF73_RS02670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GTF73_RS02685	COG1115	amino acid carrier protein
GTF73_RS02690	COG3022	response to hydroperoxide
GTF73_RS02700	COG0084	hydrolase, TatD family'
GTF73_RS02705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTF73_RS02715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GTF73_RS02720	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GTF73_RS02725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GTF73_RS02730	COG0813	purine-nucleoside phosphorylase activity
GTF73_RS02740	COG0560	Phosphoserine phosphatase
GTF73_RS02750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GTF73_RS02755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTF73_RS02760	COG1022	Amp-dependent synthetase and ligase
GTF73_RS02775	COG3250	beta-galactosidase activity
GTF73_RS02780	COG1609	Transcriptional regulator
GTF73_RS02785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF73_RS02800	COG0189	ligase activity
GTF73_RS02800	COG0569	domain protein
GTF73_RS02805	COG0456	acetyltransferase
GTF73_RS02815	COG2171	N-acyltransferase activity
GTF73_RS02820	COG3141	response to X-ray
GTF73_RS02835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GTF73_RS02840	COG1074	ATP-dependent DNA helicase activity
GTF73_RS02845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTF73_RS02855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GTF73_RS02855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GTF73_RS02865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GTF73_RS02870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GTF73_RS02875	COG2166	iron-sulfur cluster assembly
GTF73_RS02880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTF73_RS02885	COG0693	protein deglycase activity
GTF73_RS02890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTF73_RS02895	COG3248	Nucleoside-binding outer membrane protein
GTF73_RS02905	COG1595	DNA-templated transcription, initiation
GTF73_RS02915	COG2211	Major facilitator Superfamily
GTF73_RS02920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTF73_RS02930	COG2813	Specifically methylates the guanine in position
GTF73_RS02935	COG0271	Belongs to the BolA IbaG family
GTF73_RS02940	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF73_RS02945	COG1805	sodium ion transport
GTF73_RS02950	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF73_RS02955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF73_RS02960	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF73_RS02965	COG2871	sodium ion transport
GTF73_RS02970	COG1477	protein flavinylation
GTF73_RS02990	COG3706	GGDEF domain
GTF73_RS02995	COG0733	neurotransmitter:sodium symporter activity
GTF73_RS03005	COG0189	ligase activity
GTF73_RS03010	COG4067	protein conserved in archaea
GTF73_RS03010	COG0189	ligase activity
GTF73_RS03015	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTF73_RS03020	COG2252	PERMEase
GTF73_RS03025	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GTF73_RS03040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GTF73_RS03045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GTF73_RS03050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GTF73_RS03055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTF73_RS03055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTF73_RS03070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GTF73_RS03075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTF73_RS03080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GTF73_RS03085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTF73_RS03095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GTF73_RS03100	COG0024	Methionine aminopeptidase
GTF73_RS03105	COG0052	Belongs to the universal ribosomal protein uS2 family
GTF73_RS03110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GTF73_RS03115	COG0528	UMP kinase activity
GTF73_RS03120	COG0233	cytoplasmic translational termination
GTF73_RS03125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GTF73_RS03130	COG0575	Belongs to the CDS family
GTF73_RS03135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GTF73_RS03140	COG0750	zinc metalloprotease
GTF73_RS03150	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GTF73_RS03155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF73_RS03160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTF73_RS03165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF73_RS03170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF73_RS03175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTF73_RS03180	COG0587	DNA-directed DNA polymerase activity
GTF73_RS03185	COG0825	malonyl-CoA metabolic process
GTF73_RS03190	COG0037	tRNA processing
GTF73_RS03200	COG3479	Phenolic acid decarboxylase
GTF73_RS03205	COG0347	Belongs to the P(II) protein family
GTF73_RS03210	COG3021	interspecies interaction between organisms
GTF73_RS03215	COG0741	lytic transglycosylase activity
GTF73_RS03215	COG1388	LysM domain
GTF73_RS03220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTF73_RS03225	COG2226	methyltransferase
GTF73_RS03230	COG0328	RNA-DNA hybrid ribonuclease activity
GTF73_RS03245	COG1960	acyl-CoA dehydrogenase activity
GTF73_RS03250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GTF73_RS03255	COG0121	glutamine amidotransferase
GTF73_RS03260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GTF73_RS03265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GTF73_RS03270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GTF73_RS03275	COG3706	GGDEF domain
GTF73_RS03280	COG1187	pseudouridine synthase activity
GTF73_RS03285	COG2840	Smr protein MutS2
GTF73_RS03300	COG3735	TraB family
GTF73_RS03315	COG2608	mercury ion transmembrane transporter activity
GTF73_RS03315	COG2217	Heavy metal translocating P-type atpase
GTF73_RS03320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTF73_RS03335	COG1629	transport
GTF73_RS03335	COG4774	siderophore transport
GTF73_RS03340	COG2375	cellular response to nickel ion
GTF73_RS03345	COG3433	isochorismatase activity
GTF73_RS03345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTF73_RS03345	COG2226	methyltransferase
GTF73_RS03380	COG0784	Response regulator, receiver
GTF73_RS03380	COG0835	chemotaxis
GTF73_RS03385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTF73_RS03390	COG1815	bacterial-type flagellum-dependent cell motility
GTF73_RS03405	COG1749	Flagellar hook protein flgE
GTF73_RS03410	COG4787	bacterial-type flagellum-dependent cell motility
GTF73_RS03420	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GTF73_RS03425	COG1706	bacterial-type flagellum-dependent cell motility
GTF73_RS03430	COG3951	Flagellar rod assembly protein muramidase FlgJ
GTF73_RS03430	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTF73_RS03445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF73_RS03450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF73_RS03535	COG0012	GTP binding
GTF73_RS03540	COG0193	aminoacyl-tRNA hydrolase activity
GTF73_RS03545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GTF73_RS03550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GTF73_RS03555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GTF73_RS03560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GTF73_RS03565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GTF73_RS03570	COG2890	protein-(glutamine-N5) methyltransferase activity
GTF73_RS03580	COG2912	Transglutaminase-like superfamily
GTF73_RS03585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GTF73_RS03590	COG0737	Belongs to the 5'-nucleotidase family
GTF73_RS03595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTF73_RS03600	COG2233	PERMEase
GTF73_RS03620	COG1393	Belongs to the ArsC family
GTF73_RS03625	COG4783	chaperone-mediated protein folding
GTF73_RS03645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GTF73_RS03660	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GTF73_RS03670	COG1876	peptidase activity
GTF73_RS03680	COG1393	Belongs to the ArsC family
GTF73_RS03700	COG2837	iron assimilation
GTF73_RS03705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF73_RS03710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF73_RS03715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF73_RS03720	COG1334	flagellar protein FlaG
GTF73_RS03725	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GTF73_RS03735	COG1516	flagellar protein fliS
GTF73_RS03745	COG4191	Histidine kinase
GTF73_RS03755	COG1677	Flagellar hook-basal body complex protein FliE
GTF73_RS03765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTF73_RS03770	COG1317	bacterial-type flagellum organization
GTF73_RS03795	COG1580	Controls the rotational direction of flagella during chemotaxis
GTF73_RS03820	COG1987	bacterial-type flagellum assembly
GTF73_RS03825	COG1684	flagellar biosynthetic protein fliR
GTF73_RS03835	COG2840	Smr protein MutS2
GTF73_RS03840	COG2890	protein-(glutamine-N5) methyltransferase activity
GTF73_RS03845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GTF73_RS03850	COG2860	membrane
GTF73_RS03855	COG3101	peptidyl-lysine hydroxylation
GTF73_RS03865	COG0431	NADPH-dependent FMN reductase
GTF73_RS03875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTF73_RS03880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTF73_RS03885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTF73_RS03890	COG0735	belongs to the Fur family
GTF73_RS03900	COG0583	DNA-binding transcription factor activity
GTF73_RS03910	COG1346	cytolysis
GTF73_RS03925	COG0596	Alpha beta hydrolase
GTF73_RS03930	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GTF73_RS03935	COG0033	Phosphoglucomutase
GTF73_RS03945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GTF73_RS03950	COG0372	Belongs to the citrate synthase family
GTF73_RS03955	COG2009	succinate dehydrogenase
GTF73_RS03960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GTF73_RS03965	COG1053	succinate dehydrogenase
GTF73_RS03975	COG0567	Dehydrogenase, E1 component
GTF73_RS03980	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTF73_RS03985	COG0045	succinate-CoA ligase (ADP-forming) activity
GTF73_RS03995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTF73_RS04000	COG1121	(ABC) transporter
GTF73_RS04005	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GTF73_RS04010	COG4977	sequence-specific DNA binding
GTF73_RS04015	COG1918	ferrous iron import across plasma membrane
GTF73_RS04035	COG0018	arginyl-trna synthetase
GTF73_RS04045	COG1025	Belongs to the peptidase M16 family
GTF73_RS04050	COG2062	phosphohistidine phosphatase, SixA
GTF73_RS04080	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GTF73_RS04085	COG2198	Histidine kinase
GTF73_RS04085	COG0784	Response regulator, receiver
GTF73_RS04085	COG0643	Histidine kinase
GTF73_RS04090	COG2201	protein-glutamate methylesterase activity
GTF73_RS04095	COG1192	Involved in chromosome partitioning
GTF73_RS04105	COG0835	chemotaxis
GTF73_RS04115	COG4133	protoheme IX ABC transporter activity
GTF73_RS04120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTF73_RS04125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTF73_RS04135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GTF73_RS04140	COG1138	Cytochrome C-type biogenesis protein
GTF73_RS04145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTF73_RS04150	COG3088	subunit of a heme lyase
GTF73_RS04150	COG4235	cytochrome complex assembly
GTF73_RS04160	COG2853	Lipoprotein
GTF73_RS04180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GTF73_RS04185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTF73_RS04190	COG0123	including yeast histone deacetylase and acetoin utilization protein
GTF73_RS04205	COG3083	sulfuric ester hydrolase activity
GTF73_RS04210	COG3082	Protein of unknown function (DUF1414)
GTF73_RS04215	COG3081	Nucleoid-associated protein
GTF73_RS04225	COG1757	Na H antiporter
GTF73_RS04230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTF73_RS04235	COG2095	MarC family integral membrane protein
GTF73_RS04240	COG1012	belongs to the aldehyde dehydrogenase family
GTF73_RS04240	COG1454	alcohol dehydrogenase
GTF73_RS04250	COG0659	secondary active sulfate transmembrane transporter activity
GTF73_RS04255	COG1530	ribonuclease E activity
GTF73_RS04260	COG0564	pseudouridine synthase activity
GTF73_RS04265	COG0424	maF-like protein
GTF73_RS04270	COG1399	metal-binding, possibly nucleic acid-binding protein
GTF73_RS04275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GTF73_RS04280	COG0416	fatty acid biosynthetic process
GTF73_RS04285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTF73_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
GTF73_RS04300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTF73_RS04305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTF73_RS04310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTF73_RS04315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GTF73_RS04320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GTF73_RS04330	COG0084	hydrolase, TatD family'
GTF73_RS04335	COG1263	PTS System
GTF73_RS04335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF73_RS04345	COG0733	neurotransmitter:sodium symporter activity
GTF73_RS04360	COG4667	esterase of the alpha-beta hydrolase superfamily
GTF73_RS04370	COG1940	carbohydrate kinase activity
GTF73_RS04375	COG0835	chemotaxis
GTF73_RS04375	COG0784	Response regulator, receiver
GTF73_RS04390	COG2226	methyltransferase
GTF73_RS04400	COG0676	glucose-6-phosphate 1-epimerase activity
GTF73_RS04405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTF73_RS04410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF73_RS04420	COG3139	Protein of unknown function (DUF1315)
GTF73_RS04425	COG0252	asparaginase activity
GTF73_RS04430	COG0616	signal peptide processing
GTF73_RS04435	COG1902	pentaerythritol trinitrate reductase activity
GTF73_RS04435	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTF73_RS04440	COG0788	formyltetrahydrofolate deformylase activity
GTF73_RS04450	COG1199	ATP-dependent helicase activity
GTF73_RS04455	COG1214	PFAM Peptidase M22, glycoprotease
GTF73_RS04470	COG0596	Alpha beta hydrolase
GTF73_RS04475	COG0318	PFAM AMP-dependent synthetase and ligase
GTF73_RS04480	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GTF73_RS04500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GTF73_RS04505	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GTF73_RS04510	COG0436	Aminotransferase
GTF73_RS04515	COG1169	isochorismate synthase
GTF73_RS04520	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GTF73_RS04525	COG0596	Alpha beta hydrolase
GTF73_RS04545	COG3135	benzoate transporter
GTF73_RS04550	COG1396	sequence-specific DNA binding
GTF73_RS04555	COG0840	transmembrane signaling receptor activity
GTF73_RS04565	COG0477	Major facilitator Superfamily
GTF73_RS04585	COG3015	lipoprotein NlpE involved in copper resistance
GTF73_RS04590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GTF73_RS04595	COG2894	cell division
GTF73_RS04600	COG0850	regulation of cytokinetic process
GTF73_RS04605	COG3100	YcgL domain-containing protein
GTF73_RS04610	COG2951	lytic endotransglycosylase activity
GTF73_RS04620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTF73_RS04625	COG3325	Belongs to the glycosyl hydrolase 18 family
GTF73_RS04625	COG3469	chitinase activity
GTF73_RS04630	COG3005	denitrification pathway
GTF73_RS04635	COG0243	molybdopterin cofactor binding
GTF73_RS04650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF73_RS04660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GTF73_RS04695	COG4589	Belongs to the CDS family
GTF73_RS04705	COG3300	MHYT domain
GTF73_RS04705	COG5001	Diguanylate cyclase
GTF73_RS04715	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GTF73_RS04720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTF73_RS04725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GTF73_RS04730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GTF73_RS04740	COG4191	Histidine kinase
GTF73_RS04750	COG0544	peptidyl-prolyl cis-trans isomerase activity
GTF73_RS04760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GTF73_RS04765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GTF73_RS04770	COG0776	regulation of translation
GTF73_RS04775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTF73_RS04780	COG1555	photosystem II stabilization
GTF73_RS04785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GTF73_RS04790	COG0539	negative regulation of cytoplasmic translation
GTF73_RS04795	COG0776	regulation of translation
GTF73_RS04800	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GTF73_RS04805	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GTF73_RS04825	COG0583	DNA-binding transcription factor activity
GTF73_RS04835	COG0686	Belongs to the AlaDH PNT family
GTF73_RS04845	COG1674	ftsk spoiiie
GTF73_RS04850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GTF73_RS04855	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GTF73_RS04860	COG2186	Transcriptional regulator
GTF73_RS04875	COG0537	adenosine 5'-monophosphoramidase activity
GTF73_RS04900	COG3150	esterase
GTF73_RS04905	COG1252	NADH dehydrogenase
GTF73_RS04925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTF73_RS04935	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTF73_RS04940	COG1136	(ABC) transporter
GTF73_RS04945	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTF73_RS04955	COG0658	competence protein
GTF73_RS04955	COG2333	competence protein COMEC
GTF73_RS04960	COG1132	(ABC) transporter
GTF73_RS04965	COG1663	tetraacyldisaccharide 4'-kinase activity
GTF73_RS04970	COG2835	tetraacyldisaccharide 4'-kinase activity
GTF73_RS04975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GTF73_RS04980	COG2719	SpoVR family
GTF73_RS04985	COG2718	Belongs to the UPF0229 family
GTF73_RS04990	COG2766	serine protein kinase
GTF73_RS04995	COG3013	Belongs to the UPF0304 family
GTF73_RS05005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GTF73_RS05010	COG0840	transmembrane signaling receptor activity
GTF73_RS05020	COG1882	Formate acetyltransferase
GTF73_RS05045	COG4160	amino acid transport
GTF73_RS05050	COG0708	Exodeoxyribonuclease III
GTF73_RS05055	COG0840	transmembrane signaling receptor activity
GTF73_RS05065	COG3923	Primosomal replication protein n
GTF73_RS05070	COG0730	response to heat
GTF73_RS05075	COG1199	ATP-dependent helicase activity
GTF73_RS05080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTF73_RS05085	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GTF73_RS05090	COG3012	SEC-C Motif Domain Protein
GTF73_RS05095	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTF73_RS05100	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF73_RS05105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTF73_RS05110	COG0215	cysteine-tRNA ligase activity
GTF73_RS05115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GTF73_RS05120	COG0632	four-way junction helicase activity
GTF73_RS05130	COG1271	oxidase subunit
GTF73_RS05135	COG1294	oxidase, subunit
GTF73_RS05140	COG4890	Cyd operon protein YbgT
GTF73_RS05145	COG3790	cyd operon protein YbgE
GTF73_RS05150	COG0824	Thioesterase
GTF73_RS05155	COG0811	peptide transport
GTF73_RS05170	COG0823	Involved in the tonB-independent uptake of proteins
GTF73_RS05175	COG2885	chlorophyll binding
GTF73_RS05185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GTF73_RS05195	COG0784	Response regulator, receiver
GTF73_RS05195	COG5002	protein histidine kinase activity
GTF73_RS05205	COG1482	cell wall glycoprotein biosynthetic process
GTF73_RS05210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF73_RS05210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF73_RS05210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF73_RS05215	COG2207	Transcriptional regulator
GTF73_RS05225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF73_RS05230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF73_RS05235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF73_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
GTF73_RS05250	COG3284	Transcriptional regulator
GTF73_RS05255	COG4628	conserved protein (DUF2132)
GTF73_RS05265	COG0415	Belongs to the DNA photolyase family
GTF73_RS05345	COG0488	(ABC) transporter
GTF73_RS05385	COG3941	tape measure
GTF73_RS05400	COG2003	Belongs to the UPF0758 family
GTF73_RS05410	COG4409	exo-alpha-(2->6)-sialidase activity
GTF73_RS05415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTF73_RS05420	COG1940	carbohydrate kinase activity
GTF73_RS05430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTF73_RS05435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GTF73_RS05440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GTF73_RS05445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTF73_RS05450	COG1737	Transcriptional regulator
GTF73_RS05455	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GTF73_RS05460	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GTF73_RS05480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GTF73_RS05500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GTF73_RS05520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTF73_RS05525	COG0582	viral genome integration into host DNA
GTF73_RS05530	COG0582	viral genome integration into host DNA
GTF73_RS05545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF73_RS05555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTF73_RS05555	COG3008	intermembrane lipid transfer
GTF73_RS05560	COG2995	paraquat-inducible protein a
GTF73_RS05565	COG0668	transmembrane transport
GTF73_RS05585	COG1309	transcriptional regulator
GTF73_RS05590	COG1012	belongs to the aldehyde dehydrogenase family
GTF73_RS05615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTF73_RS05620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GTF73_RS05645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTF73_RS05650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTF73_RS05655	COG0297	glycogen (starch) synthase activity
GTF73_RS05675	COG3070	regulator of competence-specific genes
GTF73_RS05680	COG1609	Transcriptional regulator
GTF73_RS05685	COG3381	protein complex oligomerization
GTF73_RS05690	COG0745	RESPONSE REGULATOR receiver
GTF73_RS05695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTF73_RS05700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTF73_RS05710	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GTF73_RS05730	COG1032	radical SAM domain protein
GTF73_RS05735	COG5001	Diguanylate cyclase
GTF73_RS05740	COG0612	Peptidase, M16
GTF73_RS05755	COG0583	DNA-binding transcription factor activity
GTF73_RS05760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTF73_RS05770	COG2350	Protein conserved in bacteria
GTF73_RS05775	COG1607	acyl-coa hydrolase
GTF73_RS05790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTF73_RS05795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTF73_RS05805	COG2116	formate transmembrane transporter activity
GTF73_RS05815	COG4459	periplasmic nitrate reductase
GTF73_RS05820	COG3005	denitrification pathway
GTF73_RS05825	COG0243	molybdopterin cofactor binding
GTF73_RS05845	COG1227	inorganic diphosphatase activity
GTF73_RS05860	COG4172	Belongs to the ABC transporter superfamily
GTF73_RS05875	COG4168	peptide transport system, permease
GTF73_RS05885	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTF73_RS05890	COG1842	Phage shock protein A
GTF73_RS05905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF73_RS05920	COG2818	Glycosylase
GTF73_RS05925	COG0626	cystathionine gamma-synthase activity
GTF73_RS05935	COG0733	neurotransmitter:sodium symporter activity
GTF73_RS05940	COG0564	pseudouridine synthase activity
GTF73_RS05945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTF73_RS05950	COG4136	ATPase activity
GTF73_RS05955	COG4135	transport system, permease component
GTF73_RS05960	COG4134	Bacterial extracellular solute-binding protein
GTF73_RS05970	COG3313	Fe-S protein
GTF73_RS05980	COG0842	Transport permease protein
GTF73_RS05985	COG1131	(ABC) transporter
GTF73_RS05990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF73_RS05995	COG0814	amino acid
GTF73_RS06005	COG2239	Acts as a magnesium transporter
GTF73_RS06010	COG0784	Response regulator, receiver
GTF73_RS06010	COG2205	protein histidine kinase activity
GTF73_RS06025	COG4934	collagen metabolic process
GTF73_RS06055	COG0840	transmembrane signaling receptor activity
GTF73_RS06065	COG2203	Gaf domain
GTF73_RS06065	COG4251	negative regulation of phosphorylation
GTF73_RS06065	COG5001	Diguanylate cyclase
GTF73_RS06065	COG3706	GGDEF domain
GTF73_RS06070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GTF73_RS06090	COG1061	Type III restriction enzyme res subunit
GTF73_RS06095	COG1187	pseudouridine synthase activity
GTF73_RS06100	COG2814	Major facilitator Superfamily
GTF73_RS06110	COG0702	epimerase
GTF73_RS06115	COG0534	Mate efflux family protein
GTF73_RS06120	COG4181	ATPase activity
GTF73_RS06135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GTF73_RS06145	COG1748	Saccharopine dehydrogenase
GTF73_RS06160	COG1538	Outer membrane efflux protein
GTF73_RS06180	COG0583	DNA-binding transcription factor activity
GTF73_RS06190	COG1451	nucleotide metabolic process
GTF73_RS06205	COG3063	Type IV pilus biogenesis stability protein PilW
GTF73_RS06210	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GTF73_RS06230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF73_RS06245	COG3290	protein histidine kinase activity
GTF73_RS06250	COG4565	transcriptional regulatory protein
GTF73_RS06260	COG0835	chemotaxis
GTF73_RS06260	COG0784	Response regulator, receiver
GTF73_RS06305	COG1085	galactose-1-phosphate uridylyltransferase
GTF73_RS06310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GTF73_RS06315	COG2017	converts alpha-aldose to the beta-anomer
GTF73_RS06320	COG3706	GGDEF domain
GTF73_RS06325	COG2200	EAL domain
GTF73_RS06325	COG2199	diguanylate cyclase activity
GTF73_RS06340	COG3527	Alpha-acetolactate decarboxylase
GTF73_RS06355	COG0753	catalase activity
GTF73_RS06375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTF73_RS06385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTF73_RS06425	COG1271	oxidase subunit
GTF73_RS06430	COG1294	oxidase, subunit
GTF73_RS06435	COG1136	(ABC) transporter
GTF73_RS06435	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTF73_RS06440	COG0577	efflux transmembrane transporter activity
GTF73_RS06440	COG1136	(ABC) transporter
GTF73_RS06445	COG1136	(ABC) transporter
GTF73_RS06445	COG0577	efflux transmembrane transporter activity
GTF73_RS06465	COG0583	DNA-binding transcription factor activity
GTF73_RS06475	COG2723	6-phospho-beta-galactosidase activity
GTF73_RS06480	COG1609	Transcriptional regulator
GTF73_RS06485	COG0251	oxidation-reduction process
GTF73_RS06490	COG2731	YhcH YjgK YiaL family protein
GTF73_RS06495	COG0584	glycerophosphoryl diester phosphodiesterase
GTF73_RS06500	COG1349	DNA-binding transcription factor activity
GTF73_RS06505	COG3842	ATPase activity
GTF73_RS06510	COG0395	ABC-type sugar transport system, permease component
GTF73_RS06515	COG1175	transmembrane transport
GTF73_RS06530	COG0811	peptide transport
GTF73_RS06535	COG0811	peptide transport
GTF73_RS06540	COG0848	biopolymer transport protein
GTF73_RS06545	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GTF73_RS06555	COG1793	dna ligase
GTF73_RS06565	COG0534	Mate efflux family protein
GTF73_RS06575	COG3001	Fructosamine kinase
GTF73_RS06585	COG0791	NLP P60 protein
GTF73_RS06590	COG0840	transmembrane signaling receptor activity
GTF73_RS06605	COG1940	carbohydrate kinase activity
GTF73_RS06630	COG0746	molybdenum cofactor guanylyltransferase activity
GTF73_RS06635	COG3842	ATPase activity
GTF73_RS06640	COG4662	Binding-protein-dependent transport system inner membrane component
GTF73_RS06650	COG2204	response regulator
GTF73_RS06655	COG3852	Histidine kinase
GTF73_RS06660	COG0488	(ABC) transporter
GTF73_RS06665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GTF73_RS06695	COG3383	formate dehydrogenase (NAD+) activity
GTF73_RS06695	COG0243	molybdopterin cofactor binding
GTF73_RS06700	COG0437	4 iron, 4 sulfur cluster binding
GTF73_RS06715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTF73_RS06720	COG1666	GTP binding
GTF73_RS06725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTF73_RS06740	COG2996	Protein conserved in bacteria
GTF73_RS06750	COG3008	intermembrane lipid transfer
GTF73_RS06755	COG2995	paraquat-inducible protein a
GTF73_RS06760	COG1132	(ABC) transporter
GTF73_RS06765	COG1956	GAF domain-containing protein
GTF73_RS06770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GTF73_RS06785	COG0308	aminopeptidase N
GTF73_RS06790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GTF73_RS06860	COG1428	Deoxynucleoside kinase
GTF73_RS06945	COG4695	Portal protein
GTF73_RS07025	COG0641	radical SAM
GTF73_RS07060	COG0308	aminopeptidase N
GTF73_RS07075	COG0167	dihydroorotate dehydrogenase activity
GTF73_RS07085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTF73_RS07085	COG0116	Belongs to the methyltransferase superfamily
GTF73_RS07110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTF73_RS07115	COG1067	ATP-dependent peptidase activity
GTF73_RS07120	COG3120	sequence-specific DNA binding
GTF73_RS07195	COG1476	TRANSCRIPTIONal
GTF73_RS07225	COG4128	Pfam Zonular occludens toxin
GTF73_RS07240	COG1476	TRANSCRIPTIONal
GTF73_RS07260	COG3064	Membrane
GTF73_RS07260	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GTF73_RS07260	COG1073	alpha beta
GTF73_RS07265	COG2994	toxin metabolic process
GTF73_RS07290	COG0784	Response regulator, receiver
GTF73_RS07290	COG2205	protein histidine kinase activity
GTF73_RS07305	COG3278	Belongs to the heme-copper respiratory oxidase family
GTF73_RS07320	COG2010	Cytochrome c
GTF73_RS07330	COG2217	Heavy metal translocating P-type atpase
GTF73_RS07345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTF73_RS07350	COG0589	response to stress
GTF73_RS07375	COG3842	ATPase activity
GTF73_RS07385	COG1177	transmembrane transport
GTF73_RS07395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTF73_RS07410	COG1115	amino acid carrier protein
GTF73_RS07415	COG1280	lysine exporter protein (LysE YggA)
GTF73_RS07440	COG3501	Rhs element vgr protein
GTF73_RS07450	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GTF73_RS07460	COG2814	Major facilitator Superfamily
GTF73_RS07465	COG1566	PFAM secretion protein HlyD family protein
GTF73_RS07470	COG1538	Outer membrane efflux protein
GTF73_RS07480	COG0513	Belongs to the DEAD box helicase family
GTF73_RS07490	COG0840	transmembrane signaling receptor activity
GTF73_RS07495	COG0840	transmembrane signaling receptor activity
GTF73_RS07495	COG3290	protein histidine kinase activity
GTF73_RS07500	COG0835	chemotaxis
GTF73_RS07505	COG2201	protein-glutamate methylesterase activity
GTF73_RS07515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTF73_RS07520	COG0784	Response regulator, receiver
GTF73_RS07520	COG0643	Histidine kinase
GTF73_RS07520	COG2198	Histidine kinase
GTF73_RS07525	COG2198	Histidine kinase
GTF73_RS07525	COG0643	Histidine kinase
GTF73_RS07535	COG0745	RESPONSE REGULATOR receiver
GTF73_RS07550	COG0415	Belongs to the DNA photolyase family
GTF73_RS07555	COG0477	Major facilitator Superfamily
GTF73_RS07560	COG0583	DNA-binding transcription factor activity
GTF73_RS07570	COG0095	Lipoate-protein ligase
GTF73_RS07575	COG0443	Heat shock 70 kDa protein
GTF73_RS07585	COG1643	Atp-dependent helicase
GTF73_RS07615	COG0443	Heat shock 70 kDa protein
GTF73_RS07620	COG0443	Heat shock 70 kDa protein
GTF73_RS07625	COG3706	GGDEF domain
GTF73_RS07655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GTF73_RS07660	COG0602	queuosine metabolic process
GTF73_RS07665	COG0561	phosphatase activity
GTF73_RS07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF73_RS07680	COG4597	amino acid ABC transporter
GTF73_RS07685	COG0765	amino acid transport
GTF73_RS07690	COG1126	abc transporter atp-binding protein
GTF73_RS07695	COG0670	Belongs to the BI1 family
GTF73_RS07700	COG2920	part of a sulfur-relay system
GTF73_RS07705	COG1254	Belongs to the acylphosphatase family
GTF73_RS07710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTF73_RS07715	COG3706	GGDEF domain
GTF73_RS07730	COG3437	response regulator, receiver
GTF73_RS07735	COG0625	glutathione transferase activity
GTF73_RS07745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GTF73_RS07755	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTF73_RS07790	COG0372	Belongs to the citrate synthase family
GTF73_RS07795	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GTF73_RS07835	COG1129	ABC transporter
GTF73_RS07860	COG0745	RESPONSE REGULATOR receiver
GTF73_RS07865	COG2205	protein histidine kinase activity
GTF73_RS07870	COG3713	MltA-interacting MipA family protein
GTF73_RS07875	COG2990	Protein conserved in bacteria
GTF73_RS07885	COG4191	Histidine kinase
GTF73_RS07885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF73_RS07890	COG0471	metal ion transport
GTF73_RS07900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTF73_RS07915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF73_RS07925	COG3768	UPF0283 membrane protein
GTF73_RS07930	COG3106	COG3106 Predicted ATPase
GTF73_RS07945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTF73_RS07950	COG0494	nUDIX hydrolase
GTF73_RS07955	COG0814	amino acid
GTF73_RS07960	COG1760	l-serine dehydratase
GTF73_RS07965	COG0720	synthase
GTF73_RS07975	COG0017	Asparaginyl-tRNA synthetase
GTF73_RS07980	COG0351	phosphomethylpyrimidine kinase
GTF73_RS07990	COG1448	Aminotransferase
GTF73_RS08005	COG0840	transmembrane signaling receptor activity
GTF73_RS08010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GTF73_RS08015	COG2943	transferase activity, transferring hexosyl groups
GTF73_RS08020	COG1609	Transcriptional regulator
GTF73_RS08030	COG1486	melibiose metabolic process
GTF73_RS08035	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTF73_RS08045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTF73_RS08050	COG0726	polysaccharide deacetylase
GTF73_RS08055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTF73_RS08060	COG1846	Transcriptional regulator
GTF73_RS08085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GTF73_RS08100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTF73_RS08105	COG3108	Peptidase M15
GTF73_RS08110	COG2989	Protein conserved in bacteria
GTF73_RS08135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTF73_RS08145	COG2814	Major facilitator Superfamily
GTF73_RS08165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTF73_RS08170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTF73_RS08175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTF73_RS08225	COG4139	cobalamin transport
GTF73_RS08245	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GTF73_RS08250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GTF73_RS08255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF73_RS08265	COG2925	Exonuclease
GTF73_RS08270	COG1380	Effector of murein hydrolase LrgA
GTF73_RS08275	COG1346	cytolysis
GTF73_RS08305	COG0776	regulation of translation
GTF73_RS08310	COG0072	phenylalanine-tRNA ligase activity
GTF73_RS08310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF73_RS08315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GTF73_RS08355	COG0322	excinuclease ABC activity
GTF73_RS08360	COG2197	response regulator
GTF73_RS08365	COG0417	DNA replication proofreading
GTF73_RS08370	COG5001	Diguanylate cyclase
GTF73_RS08380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTF73_RS08385	COG3099	Belongs to the UPF0263 family
GTF73_RS08400	COG1228	amidohydrolase
GTF73_RS08405	COG0010	Belongs to the arginase family
GTF73_RS08410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GTF73_RS08415	COG2986	histidine ammonia-lyase
GTF73_RS08435	COG0247	lactate metabolic process
GTF73_RS08435	COG0277	FAD linked oxidase domain protein
GTF73_RS08450	COG2885	chlorophyll binding
GTF73_RS08470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GTF73_RS08480	COG0281	malic enzyme
GTF73_RS08490	COG2949	membrane
GTF73_RS08495	COG3706	GGDEF domain
GTF73_RS08500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTF73_RS08510	COG0492	ferredoxin-NADP+ reductase activity
GTF73_RS08515	COG4988	ABC transporter
GTF73_RS08520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GTF73_RS08525	COG1187	pseudouridine synthase activity
GTF73_RS08530	COG0009	L-threonylcarbamoyladenylate synthase
GTF73_RS08535	COG0613	PHP domain protein
GTF73_RS08545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTF73_RS08550	COG0512	Glutamine amidotransferase of anthranilate synthase
GTF73_RS08555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GTF73_RS08560	COG0135	phosphoribosylanthranilate isomerase activity
GTF73_RS08560	COG0134	indole-3-glycerol-phosphate synthase activity
GTF73_RS08565	COG0133	tryptophan synthase activity
GTF73_RS08570	COG0159	tryptophan synthase activity
GTF73_RS08580	COG1435	thymidine kinase activity
GTF73_RS08585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GTF73_RS08590	COG1801	Protein of unknown function DUF72
GTF73_RS08595	COG4106	trans-aconitate 2-methyltransferase activity
GTF73_RS08600	COG0500	methyltransferase
GTF73_RS08605	COG4067	protein conserved in archaea
GTF73_RS08605	COG0189	ligase activity
GTF73_RS08620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GTF73_RS08630	COG3852	Histidine kinase
GTF73_RS08645	COG3070	regulator of competence-specific genes
GTF73_RS08655	COG2431	L-lysine efflux transmembrane transporter activity
GTF73_RS08665	COG0076	glutamate decarboxylase activity
GTF73_RS08670	COG1737	Transcriptional regulator
GTF73_RS08675	COG1012	belongs to the aldehyde dehydrogenase family
GTF73_RS08675	COG1454	alcohol dehydrogenase
GTF73_RS08680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTF73_RS08685	COG3273	potassium ion transport
GTF73_RS08685	COG2985	domain, Protein
GTF73_RS08690	COG0542	response to heat
GTF73_RS08695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GTF73_RS08700	COG1278	Cold shock
GTF73_RS08710	COG1187	pseudouridine synthase activity
GTF73_RS08715	COG0140	phosphoribosyl-ATP diphosphatase activity
GTF73_RS08715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GTF73_RS08720	COG0107	imidazoleglycerol-phosphate synthase activity
GTF73_RS08725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GTF73_RS08730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GTF73_RS08735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GTF73_RS08735	COG0131	Imidazoleglycerol-phosphate dehydratase
GTF73_RS08740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GTF73_RS08745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GTF73_RS08750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GTF73_RS08755	COG1757	Na H antiporter
GTF73_RS08760	COG2916	Histone family protein nucleoid-structuring protein H-NS
GTF73_RS08765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF73_RS08770	COG0482	sulfurtransferase activity
GTF73_RS08775	COG2915	High frequency lysogenization protein hflD homolog
GTF73_RS08780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTF73_RS08790	COG2268	Band 7 protein
GTF73_RS08800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTF73_RS08815	COG0300	oxidoreductase activity
GTF73_RS08825	COG0501	Belongs to the peptidase M48B family
GTF73_RS08835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GTF73_RS08840	COG2226	methyltransferase
GTF73_RS08845	COG0156	8-amino-7-oxononanoate synthase activity
GTF73_RS08850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTF73_RS08855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTF73_RS08860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GTF73_RS08865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTF73_RS08870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GTF73_RS08880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTF73_RS08885	COG2203	Gaf domain
GTF73_RS08885	COG2199	diguanylate cyclase activity
GTF73_RS08895	COG4120	Belongs to the binding-protein-dependent transport system permease family
GTF73_RS08905	COG4628	conserved protein (DUF2132)
GTF73_RS08910	COG3092	negative regulation of chromosome organization
GTF73_RS08915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTF73_RS08920	COG0857	belongs to the CobB CobQ family
GTF73_RS08920	COG0280	phosphate acetyltransferase
GTF73_RS08925	COG0435	Glutathione S-transferase
GTF73_RS08930	COG4608	Belongs to the ABC transporter superfamily
GTF73_RS08935	COG0444	Belongs to the ABC transporter superfamily
GTF73_RS08940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF73_RS08945	COG0601	transmembrane transport
GTF73_RS08965	COG2204	response regulator
GTF73_RS08970	COG3300	MHYT domain
GTF73_RS08970	COG5001	Diguanylate cyclase
GTF73_RS08975	COG4191	Histidine kinase
GTF73_RS08980	COG5002	protein histidine kinase activity
GTF73_RS08990	COG2201	protein-glutamate methylesterase activity
GTF73_RS09005	COG0009	L-threonylcarbamoyladenylate synthase
GTF73_RS09020	COG1881	PFAM PEBP family protein
GTF73_RS09045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTF73_RS09050	COG0640	Transcriptional regulator
GTF73_RS09060	COG3706	GGDEF domain
GTF73_RS09080	COG1946	Acyl-CoA thioesterase
GTF73_RS09085	COG1522	sequence-specific DNA binding
GTF73_RS09095	COG0616	signal peptide processing
GTF73_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
GTF73_RS09105	COG2983	Belongs to the UPF0260 family
GTF73_RS09115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GTF73_RS09120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GTF73_RS09130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTF73_RS09135	COG2832	Protein of unknown function (DUF454)
GTF73_RS09140	COG0745	RESPONSE REGULATOR receiver
GTF73_RS09145	COG0583	DNA-binding transcription factor activity
GTF73_RS09150	COG0778	Nitroreductase
GTF73_RS09155	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTF73_RS09155	COG1024	Enoyl-CoA hydratase
GTF73_RS09160	COG0183	Belongs to the thiolase family
GTF73_RS09175	COG2067	long-chain fatty acid transport protein
GTF73_RS09185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTF73_RS09190	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GTF73_RS09195	COG2982	Protein involved in outer membrane biogenesis
GTF73_RS09200	COG0572	uridine kinase
GTF73_RS09205	COG0489	protein tyrosine kinase activity
GTF73_RS09210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF73_RS09210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF73_RS09220	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GTF73_RS09230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GTF73_RS09230	COG0617	tRNA 3'-terminal CCA addition
GTF73_RS09230	COG0517	IMP dehydrogenase activity
GTF73_RS09235	COG2199	diguanylate cyclase activity
GTF73_RS09240	COG0314	molybdopterin synthase activity
GTF73_RS09245	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GTF73_RS09250	COG0315	cyclic pyranopterin monophosphate synthase activity
GTF73_RS09255	COG0521	Mo-molybdopterin cofactor biosynthetic process
GTF73_RS09260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GTF73_RS09265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GTF73_RS09270	COG2198	Histidine kinase
GTF73_RS09275	COG2204	response regulator
GTF73_RS09280	COG0556	nucleotide-excision repair
GTF73_RS09290	COG4657	Part of a membrane complex involved in electron transport
GTF73_RS09295	COG2878	Part of a membrane complex involved in electron transport
GTF73_RS09300	COG4656	Part of a membrane complex involved in electron transport
GTF73_RS09320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTF73_RS09325	COG0346	lactoylglutathione lyase activity
GTF73_RS09340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTF73_RS09345	COG2056	Na+-H+ antiporter family
GTF73_RS09350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GTF73_RS09355	COG1286	toxin biosynthetic process
GTF73_RS09360	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GTF73_RS09365	COG0285	dihydrofolate synthase activity
GTF73_RS09370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GTF73_RS09375	COG0101	tRNA pseudouridine synthase activity
GTF73_RS09390	COG2190	(PTS) system
GTF73_RS09390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF73_RS09390	COG1263	PTS System
GTF73_RS09395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTF73_RS09400	COG1846	Transcriptional regulator
GTF73_RS09400	COG1940	carbohydrate kinase activity
GTF73_RS09405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTF73_RS09405	COG4651	solute:proton antiporter activity
GTF73_RS09410	COG0367	asparagine synthase
GTF73_RS09425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GTF73_RS09430	COG0563	adenylate kinase activity
GTF73_RS09435	COG0326	Molecular chaperone. Has ATPase activity
GTF73_RS09455	COG0622	Phosphoesterase
GTF73_RS09460	COG1090	epimerase
GTF73_RS09465	COG0300	oxidoreductase activity
GTF73_RS09470	COG3118	belongs to the thioredoxin family
GTF73_RS09475	COG0330	HflC and HflK could
GTF73_RS09480	COG1585	Membrane protein implicated in regulation of membrane protease activity
GTF73_RS09485	COG0789	Transcriptional regulator
GTF73_RS09500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GTF73_RS09505	COG3115	cell septum assembly
GTF73_RS09510	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GTF73_RS09515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTF73_RS09520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF73_RS09530	COG2190	(PTS) system
GTF73_RS09535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF73_RS09540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTF73_RS09545	COG1702	phosphate starvation-inducible protein PhoH
GTF73_RS09555	COG4535	Mg2 and Co2 transporter CorC
GTF73_RS09560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GTF73_RS09565	COG2888	peptidyl-tyrosine sulfation
GTF73_RS09570	COG0495	leucyl-tRNA aminoacylation
GTF73_RS09575	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GTF73_RS09580	COG1466	dna polymerase III delta subunit
GTF73_RS09585	COG0799	negative regulation of ribosome biogenesis
GTF73_RS09590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GTF73_RS09595	COG0768	penicillin binding
GTF73_RS09600	COG0772	Belongs to the SEDS family
GTF73_RS09605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTF73_RS09610	COG1686	Belongs to the peptidase S11 family
GTF73_RS09615	COG2921	Belongs to the UPF0250 family
GTF73_RS09620	COG0321	lipoyl(octanoyl) transferase activity
GTF73_RS09625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GTF73_RS09635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTF73_RS09660	COG1596	polysaccharide export
GTF73_RS09670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTF73_RS09700	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GTF73_RS09710	COG0438	transferase activity, transferring glycosyl groups
GTF73_RS09720	COG1045	serine acetyltransferase
GTF73_RS09740	COG0110	maltose O-acetyltransferase activity
GTF73_RS09745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GTF73_RS09750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTF73_RS09755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTF73_RS09760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTF73_RS09790	COG0366	Alpha amylase catalytic
GTF73_RS09795	COG1263	PTS System
GTF73_RS09795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF73_RS09800	COG1609	Transcriptional regulator
GTF73_RS09805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GTF73_RS09810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTF73_RS09815	COG2011	ABC-type metal ion transport system permease component
GTF73_RS09820	COG1464	Belongs to the NlpA lipoprotein family
GTF73_RS09825	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GTF73_RS09835	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTF73_RS09835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTF73_RS09845	COG3706	GGDEF domain
GTF73_RS09850	COG1611	Belongs to the LOG family
GTF73_RS09855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTF73_RS09860	COG2363	Small membrane protein
GTF73_RS09865	COG0583	DNA-binding transcription factor activity
GTF73_RS09870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTF73_RS09870	COG0301	tRNA thio-modification
GTF73_RS09880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GTF73_RS09885	COG1722	exodeoxyribonuclease VII activity
GTF73_RS09890	COG0142	geranyltranstransferase activity
GTF73_RS09895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GTF73_RS09900	COG0564	pseudouridine synthase activity
GTF73_RS09905	COG3098	single-species biofilm formation
GTF73_RS09920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF73_RS09930	COG1671	Belongs to the UPF0178 family
GTF73_RS09935	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GTF73_RS09940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTF73_RS09945	COG0254	rRNA binding
GTF73_RS09950	COG1720	tRNA m6t6A37 methyltransferase activity
GTF73_RS09955	COG0442	prolyl-tRNA aminoacylation
GTF73_RS09980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTF73_RS09980	COG0047	phosphoribosylformylglycinamidine synthase activity
GTF73_RS09990	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GTF73_RS10000	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GTF73_RS10030	COG0484	heat shock protein binding
GTF73_RS10035	COG0443	Heat shock 70 kDa protein
GTF73_RS10045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GTF73_RS10050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTF73_RS10055	COG0497	DNA recombination
GTF73_RS10060	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTF73_RS10065	COG2914	Belongs to the UPF0125 (RnfH) family
GTF73_RS10070	COG2867	negative regulation of translational initiation
GTF73_RS10075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GTF73_RS10085	COG0582	viral genome integration into host DNA
GTF73_RS10095	COG0582	viral genome integration into host DNA
GTF73_RS10100	COG3064	Membrane
GTF73_RS10110	COG0739	heme binding
GTF73_RS10130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GTF73_RS10135	COG2207	Transcriptional regulator
GTF73_RS10145	COG1459	type II secretion system
GTF73_RS10150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF73_RS10170	COG4796	Type ii and iii secretion system protein
GTF73_RS10185	COG2165	general secretion pathway protein
GTF73_RS10195	COG3710	Transcriptional regulator
GTF73_RS10200	COG0840	transmembrane signaling receptor activity
GTF73_RS10205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTF73_RS10225	COG1012	belongs to the aldehyde dehydrogenase family
GTF73_RS10280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GTF73_RS10285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GTF73_RS10290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTF73_RS10310	COG3051	citrate lyase alpha subunit
GTF73_RS10315	COG2301	Belongs to the HpcH HpaI aldolase family
GTF73_RS10325	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GTF73_RS10335	COG3630	sodium ion export across plasma membrane
GTF73_RS10340	COG0511	ligase activity, forming carbon-carbon bonds
GTF73_RS10340	COG5016	pyruvate
GTF73_RS10345	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GTF73_RS10355	COG4565	transcriptional regulatory protein
GTF73_RS10370	COG0583	DNA-binding transcription factor activity
GTF73_RS10380	COG1115	amino acid carrier protein
GTF73_RS10385	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GTF73_RS10390	COG0583	DNA-binding transcription factor activity
GTF73_RS10400	COG1120	ATPase activity
GTF73_RS10405	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF73_RS10410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF73_RS10415	COG4592	Periplasmic binding protein
GTF73_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
GTF73_RS10430	COG1169	isochorismate synthase
GTF73_RS10435	COG1021	2,3-dihydroxybenzoate-AMP ligase
GTF73_RS10440	COG3433	isochorismatase activity
GTF73_RS10440	COG1535	isochorismatase
GTF73_RS10445	COG1584	GPR1 FUN34 yaaH family protein
GTF73_RS10455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GTF73_RS10455	COG0519	Catalyzes the synthesis of GMP from XMP
GTF73_RS10460	COG0516	GMP reductase activity
GTF73_RS10460	COG0517	IMP dehydrogenase activity
GTF73_RS10465	COG1570	exodeoxyribonuclease VII activity
GTF73_RS10480	COG1160	GTP binding
GTF73_RS10485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTF73_RS10490	COG2976	Protein conserved in bacteria
GTF73_RS10495	COG0124	histidyl-tRNA synthetase
GTF73_RS10500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GTF73_RS10510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GTF73_RS10515	COG0105	UTP biosynthetic process
GTF73_RS10520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTF73_RS10525	COG2975	iron-sulfur cluster assembly
GTF73_RS10530	COG0633	Ferredoxin
GTF73_RS10535	COG0443	Heat shock 70 kDa protein
GTF73_RS10540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GTF73_RS10550	COG0822	iron-sulfur transferase activity
GTF73_RS10555	COG1104	cysteine desulfurase activity
GTF73_RS10560	COG1959	2 iron, 2 sulfur cluster binding
GTF73_RS10570	COG0483	inositol monophosphate 1-phosphatase activity
GTF73_RS10575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF73_RS10580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF73_RS10585	COG1862	Preprotein translocase
GTF73_RS10600	COG0517	IMP dehydrogenase activity
GTF73_RS10610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GTF73_RS10615	COG0583	DNA-binding transcription factor activity
GTF73_RS10620	COG0450	alkyl hydroperoxide reductase
GTF73_RS10625	COG3142	Participates in the control of copper homeostasis
GTF73_RS10640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTF73_RS10645	COG0581	inorganic phosphate transmembrane transporter activity
GTF73_RS10655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GTF73_RS10660	COG0248	Ppx GppA phosphatase
GTF73_RS10670	COG5002	protein histidine kinase activity
GTF73_RS10675	COG0745	RESPONSE REGULATOR receiver
GTF73_RS10690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTF73_RS10730	COG0542	response to heat
GTF73_RS10740	COG0564	pseudouridine synthase activity
GTF73_RS10745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTF73_RS10750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTF73_RS10755	COG0077	Prephenate dehydratase
GTF73_RS10755	COG1605	Chorismate mutase
GTF73_RS10760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTF73_RS10765	COG5001	Diguanylate cyclase
GTF73_RS10775	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GTF73_RS10785	COG0488	(ABC) transporter
GTF73_RS10795	COG1605	Chorismate mutase
GTF73_RS10795	COG0287	Prephenate dehydrogenase
GTF73_RS10800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTF73_RS10805	COG3275	phosphorelay sensor kinase activity
GTF73_RS10810	COG3279	Response regulator of the LytR AlgR family
GTF73_RS10820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GTF73_RS10825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTF73_RS10840	COG1966	Carbon starvation protein
GTF73_RS10845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GTF73_RS10850	COG1047	Peptidyl-prolyl cis-trans
GTF73_RS10865	COG0196	riboflavin kinase activity
GTF73_RS10870	COG0728	peptidoglycan biosynthetic process
GTF73_RS10875	COG0268	Binds directly to 16S ribosomal RNA
GTF73_RS10880	COG0640	Transcriptional regulator
GTF73_RS10885	COG0583	DNA-binding transcription factor activity
GTF73_RS10890	COG1283	sodium-dependent phosphate transmembrane transporter activity
GTF73_RS10900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GTF73_RS10905	COG0730	response to heat
GTF73_RS10910	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GTF73_RS10915	COG0494	nUDIX hydrolase
GTF73_RS10925	COG0667	Aldo Keto reductase
GTF73_RS10935	COG2204	response regulator
GTF73_RS10940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GTF73_RS10960	COG0513	Belongs to the DEAD box helicase family
GTF73_RS10985	COG3153	acetyltransferase
GTF73_RS10990	COG3154	lipid carrier protein
GTF73_RS11000	COG0826	peptidase U32
GTF73_RS11005	COG0826	peptidase U32
GTF73_RS11030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GTF73_RS11040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GTF73_RS11045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GTF73_RS11050	COG0195	Participates in both transcription termination and antitermination
GTF73_RS11055	COG0779	Required for maturation of 30S ribosomal subunits
GTF73_RS11070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTF73_RS11080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GTF73_RS11085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GTF73_RS11090	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GTF73_RS11095	COG1534	Rna-binding protein
GTF73_RS11100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTF73_RS11105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTF73_RS11110	COG2027	D-alanyl-D-alanine carboxypeptidase
GTF73_RS11115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTF73_RS11120	COG0739	heme binding
GTF73_RS11135	COG0316	Belongs to the HesB IscA family
GTF73_RS11140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTF73_RS11145	COG0628	permease
GTF73_RS11150	COG2813	Specifically methylates the guanine in position
GTF73_RS11155	COG2205	protein histidine kinase activity
GTF73_RS11155	COG0784	Response regulator, receiver
GTF73_RS11160	COG0747	negative chemotaxis
GTF73_RS11165	COG0601	transmembrane transport
GTF73_RS11170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF73_RS11175	COG0444	Belongs to the ABC transporter superfamily
GTF73_RS11180	COG4608	Belongs to the ABC transporter superfamily
GTF73_RS11190	COG2971	BadF BadG BcrA BcrD
GTF73_RS11210	COG3842	ATPase activity
GTF73_RS11220	COG1840	ABC-type Fe3 transport system, periplasmic component
GTF73_RS11225	COG0004	ammonium transporteR
GTF73_RS11230	COG0347	Belongs to the P(II) protein family
GTF73_RS11235	COG3112	Uncharacterised protein family (UPF0231)
GTF73_RS11240	COG1049	propionate catabolic process, 2-methylcitrate cycle
GTF73_RS11245	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTF73_RS11250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTF73_RS11255	COG1643	Atp-dependent helicase
GTF73_RS11265	COG1489	DNA binding
GTF73_RS11275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTF73_RS11285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTF73_RS11290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GTF73_RS11295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GTF73_RS11300	COG0842	Transport permease protein
GTF73_RS11305	COG1131	(ABC) transporter
GTF73_RS11310	COG0659	secondary active sulfate transmembrane transporter activity
GTF73_RS11315	COG0288	reversible hydration of carbon dioxide
GTF73_RS11330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GTF73_RS11335	COG3107	peptidoglycan biosynthetic process
GTF73_RS11340	COG0792	nuclease activity
GTF73_RS11345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GTF73_RS11350	COG2823	Periplasmic or secreted lipoprotein
GTF73_RS11355	COG2969	positive regulation of protein catabolic process
GTF73_RS11360	COG0625	glutathione transferase activity
GTF73_RS11365	COG2857	Cytochrome c1
GTF73_RS11370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GTF73_RS11375	COG0723	plastoquinol--plastocyanin reductase activity
GTF73_RS11380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GTF73_RS11385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GTF73_RS11390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GTF73_RS11400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTF73_RS11405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTF73_RS11410	COG0335	large ribosomal subunit rRNA binding
GTF73_RS11415	COG0336	Belongs to the RNA methyltransferase TrmD family
GTF73_RS11420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GTF73_RS11425	COG0228	four-way junction DNA binding
GTF73_RS11430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTF73_RS11435	COG4137	Cytochrome C assembly protein
GTF73_RS11440	COG4536	flavin adenine dinucleotide binding
GTF73_RS11445	COG1854	S-ribosylhomocysteine lyase activity
GTF73_RS11450	COG2918	glutathione biosynthetic process
GTF73_RS11455	COG0612	Peptidase, M16
GTF73_RS11460	COG1238	metal cluster binding
GTF73_RS11470	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GTF73_RS11475	COG5016	pyruvate
GTF73_RS11475	COG0511	ligase activity, forming carbon-carbon bonds
GTF73_RS11480	COG3630	sodium ion export across plasma membrane
GTF73_RS11525	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GTF73_RS11530	COG0527	aspartate kinase activity
GTF73_RS11535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTF73_RS11545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GTF73_RS11555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GTF73_RS11560	COG4208	sulfate ABC transporter
GTF73_RS11580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GTF73_RS11585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTF73_RS11595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GTF73_RS11600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GTF73_RS11605	COG0585	pseudouridine synthase activity
GTF73_RS11610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GTF73_RS11615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GTF73_RS11620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GTF73_RS11625	COG1968	undecaprenyl-diphosphatase activity
GTF73_RS11630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTF73_RS11635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTF73_RS11640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTF73_RS11650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GTF73_RS11655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTF73_RS11660	COG1610	YqeY-like protein
GTF73_RS11665	COG0358	DNA primase activity
GTF73_RS11680	COG0582	viral genome integration into host DNA
GTF73_RS11705	COG2003	Belongs to the UPF0758 family
GTF73_RS11735	COG0739	heme binding
GTF73_RS11745	COG4969	Belongs to the N-Me-Phe pilin family
GTF73_RS11760	COG0328	RNA-DNA hybrid ribonuclease activity
GTF73_RS11815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GTF73_RS11820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTF73_RS11825	COG1349	DNA-binding transcription factor activity
GTF73_RS11845	COG1279	arginine transmembrane transporter activity
GTF73_RS11850	COG0668	transmembrane transport
GTF73_RS11855	COG0191	fructose-bisphosphate aldolase activity
GTF73_RS11860	COG0126	phosphoglycerate kinase activity
GTF73_RS11865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTF73_RS11870	COG4771	TonB-dependent receptor
GTF73_RS11875	COG0583	DNA-binding transcription factor activity
GTF73_RS11880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTF73_RS11885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GTF73_RS11895	COG2356	endonuclease I
GTF73_RS11900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GTF73_RS11905	COG0189	ligase activity
GTF73_RS11910	COG1678	Uncharacterized ACR, COG1678
GTF73_RS11915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GTF73_RS11920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTF73_RS11940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GTF73_RS11945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTF73_RS11950	COG0762	integral membrane protein
GTF73_RS11955	COG1872	DUF167
GTF73_RS11965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTF73_RS11970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTF73_RS11975	COG2066	Belongs to the glutaminase family
GTF73_RS11985	COG1194	a g-specific adenine glycosylase
GTF73_RS11990	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GTF73_RS11995	COG0741	lytic transglycosylase activity
GTF73_RS12050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GTF73_RS12055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GTF73_RS12060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTF73_RS12065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GTF73_RS12070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GTF73_RS12075	COG2967	ApaG domain
GTF73_RS12080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GTF73_RS12090	COG3610	response to peptide
GTF73_RS12095	COG2966	Psort location CytoplasmicMembrane, score
GTF73_RS12100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GTF73_RS12105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GTF73_RS12110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GTF73_RS12115	COG0142	geranyltranstransferase activity
GTF73_RS12120	COG0531	amino acid
GTF73_RS12125	COG0039	L-malate dehydrogenase activity
GTF73_RS12130	COG1438	arginine binding
GTF73_RS12135	COG2358	TRAP transporter, solute receptor (TAXI family
GTF73_RS12145	COG0589	response to stress
GTF73_RS12165	COG2235	arginine
GTF73_RS12170	COG0312	modulator of DNA gyrase
GTF73_RS12175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTF73_RS12180	COG3164	Protein of unknown function
GTF73_RS12185	COG1530	ribonuclease E activity
GTF73_RS12190	COG0424	maF-like protein
GTF73_RS12195	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GTF73_RS12200	COG1792	Involved in formation and maintenance of cell shape
GTF73_RS12205	COG1077	Cell shape determining protein MreB Mrl
GTF73_RS12250	COG1459	type II secretion system
GTF73_RS12255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF73_RS12265	COG3267	Type II secretory pathway component ExeA
GTF73_RS12265	COG3409	Peptidoglycan-binding domain 1 protein
GTF73_RS12290	COG2200	EAL domain
GTF73_RS12290	COG2199	diguanylate cyclase activity
GTF73_RS12295	COG0629	single-stranded DNA binding
GTF73_RS12310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTF73_RS12320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTF73_RS12325	COG0527	aspartate kinase activity
GTF73_RS12330	COG0646	methionine synthase
GTF73_RS12330	COG1410	methionine synthase
GTF73_RS12400	COG0175	sulfate reduction
GTF73_RS12410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTF73_RS12435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTF73_RS12440	COG0735	belongs to the Fur family
GTF73_RS12460	COG0432	Pfam Uncharacterised protein family UPF0047
GTF73_RS12465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTF73_RS12480	COG0359	binds to the 23S rRNA
GTF73_RS12485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTF73_RS12490	COG2965	DNA replication, synthesis of RNA primer
GTF73_RS12495	COG0360	Binds together with S18 to 16S ribosomal RNA
GTF73_RS12505	COG2906	2 iron, 2 sulfur cluster binding
GTF73_RS12510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTF73_RS12515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTF73_RS12520	COG0049	tRNA binding
GTF73_RS12535	COG2923	Belongs to the DsrF TusC family
GTF73_RS12540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GTF73_RS12545	COG2964	Protein conserved in bacteria
GTF73_RS12550	COG0545	Peptidyl-prolyl cis-trans isomerase
GTF73_RS12560	COG2900	Belongs to the SlyX family
GTF73_RS12565	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GTF73_RS12570	COG0330	HflC and HflK could
GTF73_RS12575	COG0330	HflC and HflK could
GTF73_RS12580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTF73_RS12585	COG1923	regulation of RNA biosynthetic process
GTF73_RS12590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GTF73_RS12595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GTF73_RS12605	COG0802	atpase or kinase
GTF73_RS12610	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GTF73_RS12665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GTF73_RS12670	COG1162	GTPase activity
GTF73_RS12675	COG0688	phosphatidylethanolamine metabolic process
GTF73_RS12680	COG0471	metal ion transport
GTF73_RS12690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GTF73_RS12695	COG4942	peptidase
GTF73_RS12710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GTF73_RS12715	COG2816	NAD+ diphosphatase activity
GTF73_RS12720	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GTF73_RS12725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GTF73_RS12730	COG0085	RNA polymerase activity
GTF73_RS12735	COG0222	ribosome binding
GTF73_RS12740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GTF73_RS12750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GTF73_RS12755	COG0250	Participates in transcription elongation, termination and antitermination
GTF73_RS12760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTF73_RS12765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTF73_RS12790	COG1072	(Pantothenic acid kinase))
GTF73_RS12800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTF73_RS12810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTF73_RS12855	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GTF73_RS12870	COG3118	belongs to the thioredoxin family
GTF73_RS12875	COG0513	Belongs to the DEAD box helicase family
GTF73_RS12880	COG0248	Ppx GppA phosphatase
GTF73_RS12885	COG0784	Response regulator, receiver
GTF73_RS12885	COG2205	protein histidine kinase activity
GTF73_RS12890	COG2814	Major facilitator Superfamily
GTF73_RS12905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTF73_RS12910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GTF73_RS12915	COG0511	ligase activity, forming carbon-carbon bonds
GTF73_RS12920	COG0439	Biotin carboxylase
GTF73_RS12925	COG2264	protein methyltransferase activity
GTF73_RS12930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTF73_RS12935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GTF73_RS12940	COG1609	Transcriptional regulator
GTF73_RS12945	COG0129	dihydroxy-acid dehydratase activity
GTF73_RS12950	COG3265	gluconokinase activity
GTF73_RS12960	COG0800	Aldolase
GTF73_RS12980	COG0840	transmembrane signaling receptor activity
GTF73_RS12985	COG1982	Orn Lys Arg decarboxylase major
GTF73_RS12990	COG0531	amino acid
GTF73_RS12995	COG3710	Transcriptional regulator
GTF73_RS13000	COG0789	Transcriptional regulator
GTF73_RS13015	COG0151	Belongs to the GarS family
GTF73_RS13025	COG0776	regulation of translation
GTF73_RS13030	COG1253	flavin adenine dinucleotide binding
GTF73_RS13035	COG1940	carbohydrate kinase activity
GTF73_RS13045	COG3068	Protein conserved in bacteria
GTF73_RS13055	COG1573	uracil-dna glycosylase
GTF73_RS13060	COG0668	transmembrane transport
GTF73_RS13065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GTF73_RS13070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTF73_RS13115	COG1454	alcohol dehydrogenase
GTF73_RS13115	COG1012	belongs to the aldehyde dehydrogenase family
GTF73_RS13120	COG0318	PFAM AMP-dependent synthetase and ligase
GTF73_RS13150	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GTF73_RS13155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTF73_RS13160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GTF73_RS13160	COG0662	Cupin 2, conserved barrel domain protein
GTF73_RS13165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTF73_RS13200	COG1519	Transferase
GTF73_RS13230	COG3642	lipopolysaccharide core region biosynthetic process
GTF73_RS13235	COG0859	PFAM glycosyl transferase family 9
GTF73_RS13240	COG0463	Glycosyl transferase, family 2
GTF73_RS13245	COG0859	PFAM glycosyl transferase family 9
GTF73_RS13250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GTF73_RS13255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GTF73_RS13265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTF73_RS13270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GTF73_RS13275	COG2003	Belongs to the UPF0758 family
GTF73_RS13285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTF73_RS13295	COG1309	transcriptional regulator
GTF73_RS13300	COG1560	Kdo2-lipid A biosynthetic process
GTF73_RS13305	COG1560	Kdo2-lipid A biosynthetic process
GTF73_RS13310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GTF73_RS13315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GTF73_RS13320	COG1561	YicC-like family, N-terminal region
GTF73_RS13325	COG2862	Uncharacterized protein family, UPF0114
GTF73_RS13330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF73_RS13330	COG1263	PTS System
GTF73_RS13335	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTF73_RS13355	COG1120	ATPase activity
GTF73_RS13360	COG4774	siderophore transport
GTF73_RS13365	COG1132	(ABC) transporter
GTF73_RS13380	COG0514	ATP-dependent DNA helicase (RecQ)
GTF73_RS13385	COG2962	Rard protein
GTF73_RS13400	COG1280	lysine exporter protein (LysE YggA)
GTF73_RS13405	COG0210	DNA helicase
GTF73_RS13415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GTF73_RS13420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF73_RS13470	COG3621	Patatin-like phospholipase
GTF73_RS13495	COG2131	deaminase
GTF73_RS13505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF73_RS13515	COG0747	negative chemotaxis
GTF73_RS13565	COG1309	transcriptional regulator
GTF73_RS13570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF73_RS13575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTF73_RS13580	COG2960	long-chain fatty acid transporting porin activity
GTF73_RS13585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GTF73_RS13590	COG0583	DNA-binding transcription factor activity
GTF73_RS13635	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GTF73_RS13640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTF73_RS13645	COG1739	Uncharacterized protein family UPF0029
GTF73_RS13655	COG0183	Belongs to the thiolase family
GTF73_RS13660	COG0583	DNA-binding transcription factor activity
GTF73_RS13665	COG2814	Major facilitator Superfamily
GTF73_RS13670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTF73_RS13675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GTF73_RS13680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GTF73_RS13685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GTF73_RS13690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GTF73_RS13695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTF73_RS13700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GTF73_RS13710	COG0356	it plays a direct role in the translocation of protons across the membrane
GTF73_RS13715	COG3312	ion transport
GTF73_RS13720	COG1475	DNA binding
GTF73_RS13725	COG1192	Involved in chromosome partitioning
GTF73_RS13735	COG0445	tRNA wobble uridine modification
GTF73_RS13740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTF73_RS13745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GTF73_RS13750	COG0706	membrane insertase activity
GTF73_RS13760	COG0594	ribonuclease P activity
GTF73_RS13765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GTF73_RS13770	COG1126	abc transporter atp-binding protein
GTF73_RS13815	COG0217	transcriptional regulatory protein
GTF73_RS13820	COG2084	Dehydrogenase
GTF73_RS13835	COG2909	trisaccharide binding
GTF73_RS13840	COG0058	SHG alpha-glucan phosphorylase activity
GTF73_RS13845	COG1640	4-alpha-glucanotransferase
GTF73_RS13850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GTF73_RS13860	COG3501	Rhs element vgr protein
GTF73_RS13895	COG0471	metal ion transport
GTF73_RS13900	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GTF73_RS13940	COG0671	phosphoesterase, PA-phosphatase related
GTF73_RS13945	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GTF73_RS13955	COG1999	signal sequence binding
GTF73_RS13970	COG0786	glutamate:sodium symporter activity
GTF73_RS13990	COG1566	PFAM secretion protein HlyD family protein
GTF73_RS14000	COG3706	GGDEF domain
GTF73_RS14015	COG0813	purine-nucleoside phosphorylase activity
GTF73_RS14020	COG3272	Protein of unknown function (DUF1722)
GTF73_RS14030	COG0415	Belongs to the DNA photolyase family
GTF73_RS14035	COG1388	LysM domain
GTF73_RS14035	COG1376	ErfK ybiS ycfS ynhG family protein
GTF73_RS14045	COG0513	Belongs to the DEAD box helicase family
GTF73_RS14050	COG1770	oligopeptidase
GTF73_RS14080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTF73_RS14085	COG0573	inorganic phosphate transmembrane transporter activity
GTF73_RS14090	COG0581	inorganic phosphate transmembrane transporter activity
GTF73_RS14095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTF73_RS14115	COG0659	secondary active sulfate transmembrane transporter activity
GTF73_RS14125	COG0739	heme binding
GTF73_RS14130	COG5001	Diguanylate cyclase
GTF73_RS14130	COG3300	MHYT domain
GTF73_RS14135	COG0583	DNA-binding transcription factor activity
GTF73_RS14140	COG2814	Major facilitator Superfamily
GTF73_RS14160	COG1301	dicarboxylic acid transport
GTF73_RS14170	COG1342	Belongs to the UPF0251 family
GTF73_RS14200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTF73_RS14205	COG0673	inositol 2-dehydrogenase activity
GTF73_RS14215	COG2771	luxR family
GTF73_RS14215	COG2200	EAL domain
GTF73_RS14220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTF73_RS14230	COG0564	pseudouridine synthase activity
GTF73_RS14320	COG3501	Rhs element vgr protein
GTF73_RS14335	COG1869	D-ribose catabolic process
GTF73_RS14340	COG1129	ABC transporter
GTF73_RS14345	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTF73_RS14350	COG1879	ABC-type sugar transport system periplasmic component
GTF73_RS14355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF73_RS14360	COG1609	Transcriptional regulator
GTF73_RS14370	COG3201	nicotinamide mononucleotide transporter
GTF73_RS14375	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GTF73_RS14385	COG0584	glycerophosphoryl diester phosphodiesterase
GTF73_RS14390	COG2271	Major facilitator Superfamily
GTF73_RS14425	COG0579	oxidoreductase
GTF73_RS14435	COG0242	peptide deformylase activity
GTF73_RS14445	COG1320	monovalent cation:proton antiporter activity
GTF73_RS14450	COG2212	antiporter activity
GTF73_RS14470	COG2111	Na H antiporter
GTF73_RS14470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTF73_RS14480	COG0589	response to stress
GTF73_RS14485	COG0814	amino acid
GTF73_RS14500	COG3530	Putative quorum-sensing-regulated virulence factor
GTF73_RS14510	COG5001	Diguanylate cyclase
GTF73_RS14510	COG5002	protein histidine kinase activity
GTF73_RS14515	COG1278	Cold shock
GTF73_RS14530	COG2304	oxidoreductase activity
GTF73_RS14550	COG0714	Associated with various cellular activities
GTF73_RS14555	COG0840	transmembrane signaling receptor activity
GTF73_RS14570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTF73_RS14575	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTF73_RS14585	COG3604	Transcriptional regulator
GTF73_RS14590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTF73_RS14590	COG1017	nitric oxide dioxygenase activity
GTF73_RS14595	COG1278	Cold shock
GTF73_RS14600	COG3036	rescue of stalled ribosome
GTF73_RS14625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTF73_RS14625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GTF73_RS14630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTF73_RS14640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTF73_RS14650	COG0516	GMP reductase activity
GTF73_RS14685	COG0513	Belongs to the DEAD box helicase family
GTF73_RS14690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTF73_RS14695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GTF73_RS14700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GTF73_RS14705	COG3437	response regulator, receiver
GTF73_RS14705	COG0784	Response regulator, receiver
GTF73_RS14710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF73_RS14710	COG4191	Histidine kinase
GTF73_RS14720	COG1757	Na H antiporter
GTF73_RS14725	COG2814	Major facilitator Superfamily
GTF73_RS14735	COG3706	GGDEF domain
GTF73_RS14740	COG3240	lipase activity
GTF73_RS14750	COG0840	transmembrane signaling receptor activity
GTF73_RS14755	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GTF73_RS14760	COG5380	lipid catabolic process
GTF73_RS14785	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF73_RS14790	COG4605	iron ion homeostasis
GTF73_RS14795	COG4604	ABC transporter, ATP-binding protein
GTF73_RS14800	COG2207	Transcriptional regulator
GTF73_RS14815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTF73_RS14835	COG0745	RESPONSE REGULATOR receiver
GTF73_RS14845	COG3623	hexulose-6-phosphate isomerase
GTF73_RS14850	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GTF73_RS14855	COG0561	phosphatase activity
GTF73_RS14885	COG3038	cytochrome b561
GTF73_RS14890	COG0366	Alpha amylase catalytic
GTF73_RS14915	COG0745	RESPONSE REGULATOR receiver
GTF73_RS14920	COG5002	protein histidine kinase activity
GTF73_RS14945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTF73_RS14960	COG2814	Major facilitator Superfamily
GTF73_RS14975	COG1686	Belongs to the peptidase S11 family
GTF73_RS15000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTF73_RS15000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTF73_RS15005	COG0509	glycine decarboxylation via glycine cleavage system
GTF73_RS15010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTF73_RS15020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GTF73_RS15030	COG3039	Transposase
GTF73_RS15065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GTF73_RS15070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GTF73_RS15125	COG1028	Short-chain dehydrogenase reductase Sdr
GTF73_RS15160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GTF73_RS15185	COG0494	nUDIX hydrolase
GTF73_RS15205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF73_RS15210	COG3040	lipid binding
GTF73_RS15240	COG3041	Addiction module toxin RelE StbE family
GTF73_RS15335	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTF73_RS15385	COG0346	lactoylglutathione lyase activity
GTF73_RS15405	COG3040	lipid binding
GTF73_RS15420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GTF73_RS15430	COG1280	lysine exporter protein (LysE YggA)
GTF73_RS15615	COG3549	Plasmid maintenance system killer
GTF73_RS15620	COG3093	addiction module antidote protein HigA
GTF73_RS15640	COG0384	phenazine biosynthesis protein PhzF
GTF73_RS15670	COG0346	lactoylglutathione lyase activity
GTF73_RS15690	COG3040	lipid binding
GTF73_RS15745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF73_RS15845	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTF73_RS15870	COG3040	lipid binding
GTF73_RS15925	COG4977	sequence-specific DNA binding
GTF73_RS16015	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GTF73_RS16020	COG2944	sequence-specific DNA binding
GTF73_RS16035	COG3039	Transposase
GTF73_RS16060	COG0346	lactoylglutathione lyase activity
GTF73_RS16210	COG0346	lactoylglutathione lyase activity
GTF73_RS16230	COG1328	CTP reductase activity
GTF73_RS16235	COG0602	queuosine metabolic process
GTF73_RS16245	COG0189	ligase activity
GTF73_RS16245	COG4067	protein conserved in archaea
GTF73_RS16250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GTF73_RS16250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF73_RS16250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF73_RS16255	COG1105	Belongs to the carbohydrate kinase PfkB family
GTF73_RS16260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF73_RS16260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF73_RS16265	COG1609	Transcriptional regulator
GTF73_RS16270	COG0420	3'-5' exonuclease activity
GTF73_RS16275	COG0419	ATPase involved in DNA repair
GTF73_RS16280	COG0784	Response regulator, receiver
GTF73_RS16280	COG2205	protein histidine kinase activity
GTF73_RS16285	COG0156	8-amino-7-oxononanoate synthase activity
GTF73_RS16300	COG0523	cobalamin synthesis protein
GTF73_RS16315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTF73_RS16315	COG1013	pyruvate-flavodoxin oxidoreductase activity
GTF73_RS16315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GTF73_RS16315	COG0674	pyruvate-flavodoxin oxidoreductase activity
GTF73_RS16320	COG2205	protein histidine kinase activity
GTF73_RS16325	COG0745	RESPONSE REGULATOR receiver
GTF73_RS16330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTF73_RS16335	COG0586	Pfam SNARE associated Golgi protein
GTF73_RS16345	COG2200	EAL domain
GTF73_RS16355	COG3038	cytochrome b561
GTF73_RS16365	COG2116	formate transmembrane transporter activity
GTF73_RS16370	COG0583	DNA-binding transcription factor activity
GTF73_RS16380	COG3593	DNA synthesis involved in DNA repair
GTF73_RS16385	COG0737	Belongs to the 5'-nucleotidase family
GTF73_RS16400	COG2824	Alkylphosphonate utilization operon protein PhnA
GTF73_RS16450	COG3706	GGDEF domain
GTF73_RS16465	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GTF73_RS16470	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GTF73_RS16480	COG0745	RESPONSE REGULATOR receiver
GTF73_RS16495	COG3140	Belongs to the UPF0181 family
GTF73_RS16500	COG0023	Translation Initiation Factor
GTF73_RS16520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF73_RS16520	COG1042	CoA-binding domain protein
GTF73_RS16520	COG0045	succinate-CoA ligase (ADP-forming) activity
GTF73_RS16525	COG0583	DNA-binding transcription factor activity
GTF73_RS16530	COG1629	transport
GTF73_RS16530	COG4771	TonB-dependent receptor
GTF73_RS16545	COG2050	protein possibly involved in aromatic compounds catabolism
GTF73_RS16565	COG0625	glutathione transferase activity
GTF73_RS16580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTF73_RS16585	COG4172	Belongs to the ABC transporter superfamily
GTF73_RS16590	COG4239	(ABC) transporter, permease
GTF73_RS16595	COG4174	ABC transporter (Permease)
GTF73_RS16600	COG4166	transmembrane transport
GTF73_RS16625	COG3104	oligopeptide transport
GTF73_RS16645	COG3842	ATPase activity
GTF73_RS16655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTF73_RS16665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTF73_RS16670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTF73_RS16675	COG1011	Hydrolase
GTF73_RS16685	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GTF73_RS16690	COG1970	mechanosensitive ion channel activity
GTF73_RS16695	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GTF73_RS16700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF73_RS16700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF73_RS16705	COG0302	gtp cyclohydrolase
GTF73_RS16715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTF73_RS16725	COG2897	thiosulfate sulfurtransferase activity
GTF73_RS16730	COG2390	Transcriptional regulator
GTF73_RS16740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTF73_RS16765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTF73_RS16790	COG0583	DNA-binding transcription factor activity
GTF73_RS16795	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GTF73_RS16835	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTF73_RS16880	COG1263	PTS System
GTF73_RS16880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF73_RS16890	COG1621	beta-fructofuranosidase activity
GTF73_RS16895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF73_RS16900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTF73_RS16910	COG2885	chlorophyll binding
GTF73_RS16915	COG0545	Peptidyl-prolyl cis-trans isomerase
GTF73_RS16920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTF73_RS16925	COG0840	transmembrane signaling receptor activity
GTF73_RS16930	COG3069	C4-dicarboxylate transmembrane transporter activity
GTF73_RS16935	COG1760	l-serine dehydratase
GTF73_RS16955	COG1609	Transcriptional regulator
GTF73_RS16960	COG2197	response regulator
GTF73_RS16965	COG3850	Histidine kinase
GTF73_RS16970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTF73_RS16980	COG0243	molybdopterin cofactor binding
GTF73_RS17000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTF73_RS17005	COG2197	response regulator
GTF73_RS17010	COG3851	Histidine kinase
GTF73_RS17015	COG2271	Major facilitator Superfamily
GTF73_RS17020	COG1840	ABC-type Fe3 transport system, periplasmic component
GTF73_RS17030	COG3842	ATPase activity
GTF73_RS17035	COG3243	poly(R)-hydroxyalkanoic acid synthase
GTF73_RS17045	COG0183	Belongs to the thiolase family
GTF73_RS17055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF73_RS17060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF73_RS17075	COG3706	GGDEF domain
GTF73_RS17080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTF73_RS17090	COG1979	alcohol dehydrogenase
GTF73_RS17105	COG4191	Histidine kinase
GTF73_RS17115	COG2271	Major facilitator Superfamily
GTF73_RS17120	COG0469	pyruvate kinase activity
GTF73_RS17125	COG2198	Histidine kinase
GTF73_RS17125	COG2205	protein histidine kinase activity
GTF73_RS17125	COG0784	Response regulator, receiver
GTF73_RS17130	COG1879	ABC-type sugar transport system periplasmic component
GTF73_RS17135	COG1803	Methylglyoxal synthase
GTF73_RS17140	COG1335	isochorismatase
GTF73_RS17145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GTF73_RS17160	COG0210	DNA helicase
GTF73_RS17165	COG1289	transmembrane transporter activity
GTF73_RS17195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GTF73_RS17200	COG4149	molybdate abc transporter
GTF73_RS17205	COG0725	ABC transporter, periplasmic molybdate-binding protein
GTF73_RS17210	COG1492	cobalamin metabolic process
GTF73_RS17250	COG5002	protein histidine kinase activity
GTF73_RS17250	COG0784	Response regulator, receiver
GTF73_RS17255	COG1879	ABC-type sugar transport system periplasmic component
GTF73_RS17265	COG2827	Endonuclease containing a URI domain
GTF73_RS17280	COG2926	Belongs to the UPF0265 family
GTF73_RS17290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GTF73_RS17295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTF73_RS17300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTF73_RS17305	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GTF73_RS17310	COG0247	lactate metabolic process
GTF73_RS17315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTF73_RS17320	COG3118	belongs to the thioredoxin family
GTF73_RS17350	COG0583	DNA-binding transcription factor activity
GTF73_RS17355	COG4160	amino acid transport
GTF73_RS17360	COG4215	(ABC) transporter
GTF73_RS17365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF73_RS17370	COG1126	abc transporter atp-binding protein
GTF73_RS17380	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GTF73_RS17390	COG0494	nUDIX hydrolase
GTF73_RS17395	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GTF73_RS17405	COG1309	transcriptional regulator
GTF73_RS17410	COG0513	Belongs to the DEAD box helicase family
GTF73_RS17415	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GTF73_RS17420	COG0814	amino acid
GTF73_RS17425	COG0840	transmembrane signaling receptor activity
GTF73_RS17430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTF73_RS17435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GTF73_RS17445	COG1984	allophanate hydrolase subunit 2
GTF73_RS17460	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GTF73_RS17465	COG4181	ATPase activity
GTF73_RS17475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTF73_RS17480	COG5001	Diguanylate cyclase
GTF73_RS17480	COG1716	ATPase activity
GTF73_RS17490	COG0484	heat shock protein binding
GTF73_RS17530	COG0546	phosphoglycolate phosphatase activity
GTF73_RS17545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF73_RS17550	COG1368	sulfuric ester hydrolase activity
GTF73_RS17560	COG0513	Belongs to the DEAD box helicase family
GTF73_RS17575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTF73_RS17585	COG3046	protein related to deoxyribodipyrimidine photolyase
GTF73_RS17590	COG3397	chitin binding
GTF73_RS17595	COG3227	Zinc metalloprotease (Elastase)
GTF73_RS17605	COG0010	Belongs to the arginase family
GTF73_RS17610	COG1166	arginine decarboxylase activity
GTF73_RS17620	COG2239	Acts as a magnesium transporter
GTF73_RS17625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTF73_RS17630	COG0459	protein refolding
GTF73_RS17640	COG0527	aspartate kinase activity
GTF73_RS17645	COG0662	Cupin 2, conserved barrel domain protein
GTF73_RS17650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTF73_RS17655	COG0456	acetyltransferase
GTF73_RS17665	COG3186	Phenylalanine-4-hydroxylase
GTF73_RS17670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTF73_RS17685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTF73_RS17710	COG1253	flavin adenine dinucleotide binding
GTF73_RS17715	COG1765	OsmC-like protein
GTF73_RS17740	COG0531	amino acid
GTF73_RS17745	COG3706	GGDEF domain
GTF73_RS17755	COG3279	Response regulator of the LytR AlgR family
GTF73_RS17760	COG3275	phosphorelay sensor kinase activity
GTF73_RS17775	COG1136	(ABC) transporter
GTF73_RS17775	COG0577	efflux transmembrane transporter activity
GTF73_RS17780	COG1136	(ABC) transporter
GTF73_RS17790	COG4989	oxidoreductase activity
GTF73_RS17795	COG0366	Alpha amylase catalytic
GTF73_RS17805	COG2067	long-chain fatty acid transport protein
GTF73_RS17810	COG2267	carboxylic ester hydrolase activity
GTF73_RS17820	COG3227	Zinc metalloprotease (Elastase)
GTF73_RS17830	COG3047	cAMP biosynthetic process
GTF73_RS17840	COG1686	Belongs to the peptidase S11 family
GTF73_RS17845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTF73_RS17850	COG1271	oxidase subunit
GTF73_RS17855	COG1294	oxidase, subunit
GTF73_RS17870	COG3048	D-serine ammonia-lyase activity
GTF73_RS17875	COG0583	DNA-binding transcription factor activity
GTF73_RS17920	COG1063	alcohol dehydrogenase
GTF73_RS17945	COG0346	lactoylglutathione lyase activity
GTF73_RS17965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GTF73_RS17970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTF73_RS17975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GTF73_RS17980	COG0363	glucosamine-6-phosphate deaminase activity
GTF73_RS17985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTF73_RS18010	COG1929	Belongs to the glycerate kinase type-1 family
GTF73_RS18015	COG2610	gluconate transmembrane transporter activity
GTF73_RS18020	COG3835	regulator
GTF73_RS18030	COG0748	coenzyme F420 binding
GTF73_RS18035	COG3721	Heme iron utilization protein
GTF73_RS18045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GTF73_RS18050	COG0811	peptide transport
GTF73_RS18055	COG0848	biopolymer transport protein
GTF73_RS18060	COG4558	Periplasmic binding protein
GTF73_RS18065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF73_RS18070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GTF73_RS18105	COG0633	Ferredoxin
GTF73_RS18105	COG3217	Mosc domain protein beta barrel domain protein
GTF73_RS18105	COG3217	Mosc domain protein beta barrel domain protein
GTF73_RS18105	COG0633	Ferredoxin
GTF73_RS18110	COG0418	dihydroorotase activity
GTF73_RS18120	COG3152	Membrane
GTF73_RS18130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTF73_RS18135	COG2354	Protein conserved in bacteria
GTF73_RS18140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTF73_RS18145	COG1278	Cold shock
GTF73_RS18170	COG3706	GGDEF domain
GTF73_RS18175	COG1349	DNA-binding transcription factor activity
GTF73_RS18190	COG3833	ABC-type maltose transport systems, permease component
GTF73_RS18195	COG1175	transmembrane transport
GTF73_RS18205	COG3842	ATPase activity
GTF73_RS18210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF73_RS18225	COG0393	Putative heavy-metal-binding
GTF73_RS18235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTF73_RS18240	COG0835	chemotaxis
GTF73_RS18240	COG0784	Response regulator, receiver
GTF73_RS18245	COG1846	Transcriptional regulator
GTF73_RS18250	COG3706	GGDEF domain
GTF73_RS18285	COG0583	DNA-binding transcription factor activity
GTF73_RS18290	COG5001	Diguanylate cyclase
GTF73_RS18300	COG1741	Belongs to the pirin family
GTF73_RS18305	COG3123	guanosine phosphorylase activity
GTF73_RS18315	COG2211	Major facilitator Superfamily
GTF73_RS18320	COG0840	transmembrane signaling receptor activity
GTF73_RS18325	COG1067	ATP-dependent peptidase activity
GTF73_RS18335	COG4172	Belongs to the ABC transporter superfamily
GTF73_RS18360	COG0583	DNA-binding transcription factor activity
GTF73_RS18370	COG1620	l-lactate permease
GTF73_RS18385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GTF73_RS18395	COG0840	transmembrane signaling receptor activity
GTF73_RS18405	COG0513	Belongs to the DEAD box helicase family
GTF73_RS18410	COG0583	DNA-binding transcription factor activity
GTF73_RS18420	COG1902	pentaerythritol trinitrate reductase activity
GTF73_RS18430	COG1132	(ABC) transporter
GTF73_RS18440	COG1902	pentaerythritol trinitrate reductase activity
GTF73_RS18450	COG1280	lysine exporter protein (LysE YggA)
GTF73_RS18455	COG2207	Transcriptional regulator
GTF73_RS18475	COG1846	Transcriptional regulator
GTF73_RS18480	COG1764	response to oxidative stress
GTF73_RS18485	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTF73_RS18490	COG0697	spore germination
GTF73_RS18500	COG0700	Nucleoside recognition
GTF73_RS18505	COG3366	ferrous iron transmembrane transporter activity
GTF73_RS18510	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTF73_RS18520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTF73_RS18525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GTF73_RS18530	COG2259	Doxx family
GTF73_RS18555	COG0363	glucosamine-6-phosphate deaminase activity
GTF73_RS18570	COG4580	involved in the transport of maltose and maltodextrins
GTF73_RS18585	COG0840	transmembrane signaling receptor activity
GTF73_RS18600	COG0840	transmembrane signaling receptor activity
GTF73_RS18610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTF73_RS18615	COG1126	abc transporter atp-binding protein
GTF73_RS18625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF73_RS18630	COG4597	amino acid ABC transporter
GTF73_RS18635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTF73_RS18650	COG2213	PTS system mannitol-specific
GTF73_RS18650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF73_RS18655	COG0246	Mannitol dehydrogenase
GTF73_RS18660	COG3722	fumarate hydratase activity
GTF73_RS18665	COG0673	inositol 2-dehydrogenase activity
GTF73_RS18695	COG2910	NAD(P)H-binding
GTF73_RS18705	COG0840	transmembrane signaling receptor activity
GTF73_RS18710	COG4221	oxidoreductase activity
GTF73_RS18720	COG1901	pseudouridine methyltransferase
GTF73_RS18735	COG0531	amino acid
GTF73_RS18740	COG1982	Orn Lys Arg decarboxylase major
GTF73_RS18770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTF73_RS18795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GTF73_RS18835	COG0745	RESPONSE REGULATOR receiver
GTF73_RS18860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTF73_RS18865	COG0840	transmembrane signaling receptor activity
GTF73_RS18870	COG0835	chemotaxis
GTF73_RS18875	COG0835	chemotaxis
GTF73_RS18880	COG0643	Histidine kinase
GTF73_RS18880	COG2198	Histidine kinase
GTF73_RS18900	COG0601	transmembrane transport
GTF73_RS18905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF73_RS18915	COG2194	sulfuric ester hydrolase activity
GTF73_RS18920	COG0642	Histidine kinase
GTF73_RS18925	COG0745	RESPONSE REGULATOR receiver
GTF73_RS18955	COG1444	tRNA N-acetyltransferase activity
GTF73_RS18960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine