locus-tag	class	description
GTF74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GTF74_RS00010	COG0592	DNA-directed DNA polymerase activity
GTF74_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTF74_RS00020	COG0187	DNA topoisomerase II activity
GTF74_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
GTF74_RS00035	COG3977	Valine--pyruvate aminotransferase
GTF74_RS00040	COG0751	glycine-tRNA ligase activity
GTF74_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
GTF74_RS00050	COG2119	membrane
GTF74_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
GTF74_RS00070	COG0604	alcohol dehydrogenase
GTF74_RS00080	COG0129	dihydroxy-acid dehydratase activity
GTF74_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTF74_RS00100	COG0606	chelatase, subunit chli
GTF74_RS00105	COG0204	Acyl-transferase
GTF74_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTF74_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTF74_RS00125	COG3084	Protein conserved in bacteria
GTF74_RS00130	COG4326	sporulation control protein
GTF74_RS00135	COG1272	protein, Hemolysin III
GTF74_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTF74_RS00150	COG0569	domain protein
GTF74_RS00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTF74_RS00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTF74_RS00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GTF74_RS00165	COG0242	peptide deformylase activity
GTF74_RS00170	COG1652	LysM domain
GTF74_RS00175	COG0758	DNA mediated transformation
GTF74_RS00180	COG2922	Belongs to the Smg family
GTF74_RS00185	COG0551	DNA topoisomerase type I activity
GTF74_RS00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GTF74_RS00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GTF74_RS00200	COG0009	L-threonylcarbamoyladenylate synthase
GTF74_RS00205	COG0408	coproporphyrinogen oxidase activity
GTF74_RS00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GTF74_RS00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTF74_RS00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTF74_RS00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GTF74_RS00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTF74_RS00280	COG2104	thiamine diphosphate biosynthetic process
GTF74_RS00285	COG2022	thiamine diphosphate biosynthetic process
GTF74_RS00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTF74_RS00295	COG0006	proline dipeptidase activity
GTF74_RS00295	COG0006	proline dipeptidase activity
GTF74_RS00315	COG1522	sequence-specific DNA binding
GTF74_RS00320	COG5001	Diguanylate cyclase
GTF74_RS00320	COG5002	protein histidine kinase activity
GTF74_RS00340	COG0589	response to stress
GTF74_RS00345	COG1528	Iron-storage protein
GTF74_RS00355	COG2081	HI0933 family
GTF74_RS00365	COG1322	Protein conserved in bacteria
GTF74_RS00370	COG2226	methyltransferase
GTF74_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTF74_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTF74_RS00395	COG0805	protein transport
GTF74_RS00400	COG1858	cytochrome C peroxidase
GTF74_RS00405	COG0534	Mate efflux family protein
GTF74_RS00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTF74_RS00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GTF74_RS00430	COG3161	chorismate lyase activity
GTF74_RS00435	COG1580	Controls the rotational direction of flagella during chemotaxis
GTF74_RS00440	COG0840	transmembrane signaling receptor activity
GTF74_RS00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTF74_RS00455	COG0084	hydrolase, TatD family'
GTF74_RS00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTF74_RS00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTF74_RS00490	COG3078	GTPase activator activity
GTF74_RS00505	COG3071	HemY protein
GTF74_RS00510	COG2959	enzyme of heme biosynthesis
GTF74_RS00520	COG0181	hydroxymethylbilane synthase activity
GTF74_RS00530	COG1965	Belongs to the frataxin family
GTF74_RS00540	COG0019	diaminopimelate decarboxylase activity
GTF74_RS00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GTF74_RS00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GTF74_RS00560	COG1011	Hydrolase
GTF74_RS00565	COG2200	EAL domain
GTF74_RS00565	COG3287	FIST C domain
GTF74_RS00565	COG2199	diguanylate cyclase activity
GTF74_RS00580	COG0561	phosphatase activity
GTF74_RS00585	COG2267	carboxylic ester hydrolase activity
GTF74_RS00590	COG1280	lysine exporter protein (LysE YggA)
GTF74_RS00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTF74_RS00600	COG0783	Belongs to the Dps family
GTF74_RS00630	COG0742	ribosomal rna small subunit methyltransferase
GTF74_RS00635	COG0552	protein localization to endoplasmic reticulum
GTF74_RS00640	COG2884	Cell division ATP-binding protein ftsE
GTF74_RS00645	COG2177	Part of the ABC transporter FtsEX involved in
GTF74_RS00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTF74_RS00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF74_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTF74_RS00675	COG4206	TonB-dependent receptor
GTF74_RS00680	COG1404	Belongs to the peptidase S8 family
GTF74_RS00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTF74_RS00755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GTF74_RS00760	COG5001	Diguanylate cyclase
GTF74_RS00760	COG3300	MHYT domain
GTF74_RS00770	COG3852	Histidine kinase
GTF74_RS00780	COG0174	glutamine synthetase
GTF74_RS00800	COG1295	ribonuclease BN
GTF74_RS00805	COG1490	D-aminoacyl-tRNA deacylase activity
GTF74_RS00810	COG0456	acetyltransferase
GTF74_RS00820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GTF74_RS00825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GTF74_RS00830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTF74_RS00835	COG3031	protein transport across the cell outer membrane
GTF74_RS00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF74_RS00850	COG1459	type II secretion system
GTF74_RS00855	COG2165	general secretion pathway protein
GTF74_RS00860	COG2165	general secretion pathway protein
GTF74_RS00865	COG2165	general secretion pathway protein
GTF74_RS00870	COG4795	General secretion pathway protein
GTF74_RS00875	COG3156	type II secretion system protein K
GTF74_RS00880	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GTF74_RS00885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GTF74_RS00895	COG1218	3'(2'),5'-bisphosphate nucleotidase
GTF74_RS00900	COG0494	nUDIX hydrolase
GTF74_RS00910	COG1040	competence protein
GTF74_RS00920	COG0596	Alpha beta hydrolase
GTF74_RS00930	COG2183	response to ionizing radiation
GTF74_RS00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTF74_RS00940	COG0745	RESPONSE REGULATOR receiver
GTF74_RS00950	COG2233	PERMEase
GTF74_RS00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTF74_RS00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTF74_RS00965	COG1758	RNA polymerase activity
GTF74_RS00970	COG0194	GDP metabolic process
GTF74_RS00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GTF74_RS00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTF74_RS01000	COG4232	protein-disulfide reductase activity
GTF74_RS01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTF74_RS01015	COG1027	Aspartate ammonia-lyase
GTF74_RS01020	COG3706	GGDEF domain
GTF74_RS01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
GTF74_RS01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GTF74_RS01040	COG2205	protein histidine kinase activity
GTF74_RS01045	COG0745	RESPONSE REGULATOR receiver
GTF74_RS01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTF74_RS01060	COG0205	6-phosphofructokinase activity
GTF74_RS01065	COG1494	fructose-1,6-bisphosphatase
GTF74_RS01070	COG3074	FtsZ-dependent cytokinesis
GTF74_RS01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GTF74_RS01080	COG0527	aspartate kinase activity
GTF74_RS01080	COG0460	homoserine dehydrogenase
GTF74_RS01085	COG0626	cystathionine gamma-synthase activity
GTF74_RS01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GTF74_RS01095	COG0281	malic enzyme
GTF74_RS01100	COG0254	rRNA binding
GTF74_RS01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTF74_RS01110	COG1609	Transcriptional regulator
GTF74_RS01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTF74_RS01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GTF74_RS01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GTF74_RS01130	COG1575	Belongs to the MenA family. Type 1 subfamily
GTF74_RS01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTF74_RS01140	COG0534	Mate efflux family protein
GTF74_RS01145	COG0149	triose-phosphate isomerase activity
GTF74_RS01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTF74_RS01175	COG0459	protein refolding
GTF74_RS01185	COG1509	lysine 2,3-aminomutase activity
GTF74_RS01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTF74_RS01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GTF74_RS01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GTF74_RS01210	COG1053	succinate dehydrogenase
GTF74_RS01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GTF74_RS01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTF74_RS01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GTF74_RS01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GTF74_RS01235	COG1045	serine acetyltransferase
GTF74_RS01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GTF74_RS01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTF74_RS01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GTF74_RS01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GTF74_RS01265	COG0137	argininosuccinate synthase activity
GTF74_RS01270	COG0165	Argininosuccinate lyase
GTF74_RS01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF74_RS01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTF74_RS01285	COG0678	peroxiredoxin activity
GTF74_RS01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GTF74_RS01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GTF74_RS01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GTF74_RS01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GTF74_RS01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTF74_RS01350	COG0546	phosphoglycolate phosphatase activity
GTF74_RS01355	COG0180	Tryptophanyl-tRNA synthetase
GTF74_RS01370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTF74_RS01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTF74_RS01390	COG1012	belongs to the aldehyde dehydrogenase family
GTF74_RS01405	COG3954	Phosphoribulokinase
GTF74_RS01415	COG0429	hydrolase of the alpha beta-hydrolase fold
GTF74_RS01425	COG0488	(ABC) transporter
GTF74_RS01430	COG2249	NAD(P)H dehydrogenase (quinone) activity
GTF74_RS01445	COG1047	Peptidyl-prolyl cis-trans
GTF74_RS01460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GTF74_RS01465	COG3083	sulfuric ester hydrolase activity
GTF74_RS01470	COG0557	exoribonuclease II activity
GTF74_RS01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTF74_RS01480	COG0051	transcription antitermination factor activity, RNA binding
GTF74_RS01485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GTF74_RS01490	COG0088	Forms part of the polypeptide exit tunnel
GTF74_RS01495	COG0089	rRNA binding
GTF74_RS01500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GTF74_RS01505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GTF74_RS01510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GTF74_RS01515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GTF74_RS01520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTF74_RS01525	COG0255	Belongs to the universal ribosomal protein uL29 family
GTF74_RS01530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GTF74_RS01535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GTF74_RS01540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GTF74_RS01545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GTF74_RS01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GTF74_RS01555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GTF74_RS01565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GTF74_RS01570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GTF74_RS01575	COG1841	ribosomal large subunit assembly
GTF74_RS01585	COG0201	protein transport
GTF74_RS01590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTF74_RS01595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GTF74_RS01600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GTF74_RS01605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GTF74_RS01610	COG0202	RNA polymerase activity
GTF74_RS01615	COG0203	ribosomal protein L17
GTF74_RS01625	COG0545	Peptidyl-prolyl cis-trans isomerase
GTF74_RS01630	COG3266	domain, Protein
GTF74_RS01630	COG3061	Opacity-associated protein A
GTF74_RS01635	COG0697	spore germination
GTF74_RS01640	COG2153	protein acetylation
GTF74_RS01645	COG0513	Belongs to the DEAD box helicase family
GTF74_RS01655	COG0737	Belongs to the 5'-nucleotidase family
GTF74_RS01660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTF74_RS01660	COG1648	precorrin-2 dehydrogenase activity
GTF74_RS01675	COG0529	Catalyzes the synthesis of activated sulfate
GTF74_RS01695	COG1136	(ABC) transporter
GTF74_RS01710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GTF74_RS01715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF74_RS01720	COG0729	surface antigen
GTF74_RS01730	COG2105	PFAM AIG2 family protein
GTF74_RS01735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GTF74_RS01745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTF74_RS01750	COG0163	prenyltransferase activity
GTF74_RS01760	COG1178	ABC-type Fe3 transport system permease component
GTF74_RS01765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GTF74_RS01770	COG3028	Belongs to the UPF0307 family
GTF74_RS01775	COG0312	modulator of DNA gyrase
GTF74_RS01780	COG2239	Acts as a magnesium transporter
GTF74_RS01785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF74_RS01790	COG1660	Displays ATPase and GTPase activities
GTF74_RS01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF74_RS01800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTF74_RS01810	COG1137	ATPase activity
GTF74_RS01815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GTF74_RS01830	COG0517	IMP dehydrogenase activity
GTF74_RS01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GTF74_RS01840	COG1127	ABC transporter
GTF74_RS01845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GTF74_RS01850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTF74_RS01855	COG2854	intermembrane phospholipid transfer
GTF74_RS01865	COG5007	Belongs to the BolA IbaG family
GTF74_RS01870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTF74_RS01880	COG0251	oxidation-reduction process
GTF74_RS01890	COG0540	Belongs to the ATCase OTCase family
GTF74_RS01900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GTF74_RS01910	COG0564	pseudouridine synthase activity
GTF74_RS01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTF74_RS01920	COG0525	valine-tRNA ligase activity
GTF74_RS01925	COG2927	DNA polymerase III (CHI subunit)
GTF74_RS01930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTF74_RS01935	COG0795	lipopolysaccharide-transporting ATPase activity
GTF74_RS01940	COG0795	lipopolysaccharide-transporting ATPase activity
GTF74_RS01955	COG3437	response regulator, receiver
GTF74_RS02000	COG0066	3-isopropylmalate dehydratase activity
GTF74_RS02005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GTF74_RS02010	COG0473	3-isopropylmalate dehydrogenase activity
GTF74_RS02035	COG0583	DNA-binding transcription factor activity
GTF74_RS02040	COG1022	Amp-dependent synthetase and ligase
GTF74_RS02045	COG0028	Belongs to the TPP enzyme family
GTF74_RS02050	COG0440	acetolactate synthase activity
GTF74_RS02055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTF74_RS02060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GTF74_RS02065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTF74_RS02075	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GTF74_RS02080	COG3079	Belongs to the UPF0149 family
GTF74_RS02085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF74_RS02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF74_RS02105	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GTF74_RS02115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GTF74_RS02120	COG1595	DNA-templated transcription, initiation
GTF74_RS02135	COG3086	response to oxidative stress
GTF74_RS02140	COG0481	GTPase activity
GTF74_RS02155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GTF74_RS02160	COG1381	Involved in DNA repair and RecF pathway recombination
GTF74_RS02165	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GTF74_RS02185	COG5001	Diguanylate cyclase
GTF74_RS02200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTF74_RS02205	COG3956	TIGRFAM MazG family protein
GTF74_RS02210	COG0504	CTP synthase activity
GTF74_RS02215	COG0148	phosphopyruvate hydratase activity
GTF74_RS02225	COG3267	Type II secretory pathway component ExeA
GTF74_RS02225	COG3409	Peptidoglycan-binding domain 1 protein
GTF74_RS02235	COG4991	sh3 domain protein
GTF74_RS02240	COG0306	phosphate transporter
GTF74_RS02245	COG1392	Phosphate transport regulator
GTF74_RS02250	COG3025	triphosphatase activity
GTF74_RS02255	COG0840	transmembrane signaling receptor activity
GTF74_RS02260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GTF74_RS02270	COG1538	Outer membrane efflux protein
GTF74_RS02275	COG0494	nUDIX hydrolase
GTF74_RS02280	COG3151	Protein conserved in bacteria
GTF74_RS02290	COG3150	esterase
GTF74_RS02295	COG0187	DNA topoisomerase II activity
GTF74_RS02300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTF74_RS02310	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GTF74_RS02315	COG0237	dephospho-CoA kinase activity
GTF74_RS02325	COG1459	type II secretion system
GTF74_RS02330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF74_RS02350	COG0716	FMN binding
GTF74_RS02355	COG4974	Belongs to the 'phage' integrase family
GTF74_RS02360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTF74_RS02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTF74_RS02370	COG0737	Belongs to the 5'-nucleotidase family
GTF74_RS02375	COG2186	Transcriptional regulator
GTF74_RS02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GTF74_RS02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTF74_RS02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF74_RS02405	COG3116	cell division
GTF74_RS02410	COG0768	penicillin binding
GTF74_RS02415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTF74_RS02420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTF74_RS02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTF74_RS02435	COG0772	Belongs to the SEDS family
GTF74_RS02445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTF74_RS02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GTF74_RS02455	COG0849	cell division
GTF74_RS02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTF74_RS02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GTF74_RS02475	COG0653	protein targeting
GTF74_RS02480	COG0494	nUDIX hydrolase
GTF74_RS02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GTF74_RS02495	COG0505	Belongs to the CarA family
GTF74_RS02500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTF74_RS02515	COG4172	Belongs to the ABC transporter superfamily
GTF74_RS02525	COG0730	response to heat
GTF74_RS02530	COG0583	DNA-binding transcription factor activity
GTF74_RS02535	COG2860	membrane
GTF74_RS02540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTF74_RS02550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GTF74_RS02560	COG0493	'glutamate synthase
GTF74_RS02565	COG0069	glutamate synthase activity
GTF74_RS02565	COG0070	glutamate synthase
GTF74_RS02565	COG0067	glutamate synthase
GTF74_RS02575	COG0070	glutamate synthase
GTF74_RS02575	COG0069	glutamate synthase activity
GTF74_RS02575	COG0067	glutamate synthase
GTF74_RS02580	COG1242	4 iron, 4 sulfur cluster binding
GTF74_RS02585	COG3706	GGDEF domain
GTF74_RS02585	COG4251	negative regulation of phosphorylation
GTF74_RS02585	COG5001	Diguanylate cyclase
GTF74_RS02585	COG2203	Gaf domain
GTF74_RS02590	COG0784	Response regulator, receiver
GTF74_RS02590	COG2198	Histidine kinase
GTF74_RS02590	COG5002	protein histidine kinase activity
GTF74_RS02595	COG0745	RESPONSE REGULATOR receiver
GTF74_RS02605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GTF74_RS02630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GTF74_RS02635	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GTF74_RS02640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GTF74_RS02645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GTF74_RS02660	COG1115	amino acid carrier protein
GTF74_RS02665	COG3022	response to hydroperoxide
GTF74_RS02675	COG0084	hydrolase, TatD family'
GTF74_RS02680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTF74_RS02690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GTF74_RS02695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GTF74_RS02700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GTF74_RS02705	COG0813	purine-nucleoside phosphorylase activity
GTF74_RS02715	COG0560	Phosphoserine phosphatase
GTF74_RS02725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GTF74_RS02730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTF74_RS02735	COG1022	Amp-dependent synthetase and ligase
GTF74_RS02750	COG3250	beta-galactosidase activity
GTF74_RS02755	COG1609	Transcriptional regulator
GTF74_RS02760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF74_RS02775	COG0569	domain protein
GTF74_RS02775	COG0189	ligase activity
GTF74_RS02780	COG0456	acetyltransferase
GTF74_RS02790	COG2171	N-acyltransferase activity
GTF74_RS02795	COG3141	response to X-ray
GTF74_RS02810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GTF74_RS02815	COG1074	ATP-dependent DNA helicase activity
GTF74_RS02820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTF74_RS02840	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GTF74_RS02845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GTF74_RS02850	COG2166	iron-sulfur cluster assembly
GTF74_RS02855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTF74_RS02860	COG0693	protein deglycase activity
GTF74_RS02865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTF74_RS02870	COG3248	Nucleoside-binding outer membrane protein
GTF74_RS02880	COG1595	DNA-templated transcription, initiation
GTF74_RS02890	COG2211	Major facilitator Superfamily
GTF74_RS02895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTF74_RS02905	COG2813	Specifically methylates the guanine in position
GTF74_RS02910	COG0271	Belongs to the BolA IbaG family
GTF74_RS02915	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF74_RS02920	COG1805	sodium ion transport
GTF74_RS02925	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF74_RS02930	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF74_RS02935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GTF74_RS02940	COG2871	sodium ion transport
GTF74_RS02945	COG1477	protein flavinylation
GTF74_RS02965	COG3706	GGDEF domain
GTF74_RS02970	COG0733	neurotransmitter:sodium symporter activity
GTF74_RS02980	COG0189	ligase activity
GTF74_RS02985	COG4067	protein conserved in archaea
GTF74_RS02985	COG0189	ligase activity
GTF74_RS02990	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTF74_RS02995	COG2252	PERMEase
GTF74_RS03000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GTF74_RS03015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GTF74_RS03020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GTF74_RS03025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GTF74_RS03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTF74_RS03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTF74_RS03045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GTF74_RS03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTF74_RS03055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GTF74_RS03060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTF74_RS03070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GTF74_RS03075	COG0024	Methionine aminopeptidase
GTF74_RS03080	COG0052	Belongs to the universal ribosomal protein uS2 family
GTF74_RS03085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GTF74_RS03090	COG0528	UMP kinase activity
GTF74_RS03095	COG0233	cytoplasmic translational termination
GTF74_RS03100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GTF74_RS03105	COG0575	Belongs to the CDS family
GTF74_RS03110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GTF74_RS03115	COG0750	zinc metalloprotease
GTF74_RS03125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GTF74_RS03130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF74_RS03135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTF74_RS03140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF74_RS03145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF74_RS03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTF74_RS03155	COG0587	DNA-directed DNA polymerase activity
GTF74_RS03160	COG0825	malonyl-CoA metabolic process
GTF74_RS03165	COG0037	tRNA processing
GTF74_RS03175	COG3479	Phenolic acid decarboxylase
GTF74_RS03180	COG0347	Belongs to the P(II) protein family
GTF74_RS03185	COG3021	interspecies interaction between organisms
GTF74_RS03190	COG0741	lytic transglycosylase activity
GTF74_RS03190	COG1388	LysM domain
GTF74_RS03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTF74_RS03200	COG2226	methyltransferase
GTF74_RS03205	COG0328	RNA-DNA hybrid ribonuclease activity
GTF74_RS03220	COG1960	acyl-CoA dehydrogenase activity
GTF74_RS03225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GTF74_RS03230	COG0121	glutamine amidotransferase
GTF74_RS03235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GTF74_RS03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GTF74_RS03245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GTF74_RS03250	COG3706	GGDEF domain
GTF74_RS03255	COG1187	pseudouridine synthase activity
GTF74_RS03260	COG2840	Smr protein MutS2
GTF74_RS03275	COG3735	TraB family
GTF74_RS03290	COG2217	Heavy metal translocating P-type atpase
GTF74_RS03290	COG2608	mercury ion transmembrane transporter activity
GTF74_RS03295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTF74_RS03310	COG1629	transport
GTF74_RS03310	COG4774	siderophore transport
GTF74_RS03315	COG2375	cellular response to nickel ion
GTF74_RS03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTF74_RS03320	COG2226	methyltransferase
GTF74_RS03320	COG3433	isochorismatase activity
GTF74_RS03355	COG0784	Response regulator, receiver
GTF74_RS03355	COG0835	chemotaxis
GTF74_RS03360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTF74_RS03365	COG1815	bacterial-type flagellum-dependent cell motility
GTF74_RS03380	COG1749	Flagellar hook protein flgE
GTF74_RS03385	COG4787	bacterial-type flagellum-dependent cell motility
GTF74_RS03395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GTF74_RS03400	COG1706	bacterial-type flagellum-dependent cell motility
GTF74_RS03405	COG3951	Flagellar rod assembly protein muramidase FlgJ
GTF74_RS03405	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTF74_RS03420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF74_RS03425	COG4974	Belongs to the 'phage' integrase family
GTF74_RS03520	COG4695	Portal protein
GTF74_RS03645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF74_RS03730	COG0012	GTP binding
GTF74_RS03735	COG0193	aminoacyl-tRNA hydrolase activity
GTF74_RS03740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GTF74_RS03745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GTF74_RS03750	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GTF74_RS03755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GTF74_RS03760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GTF74_RS03765	COG2890	protein-(glutamine-N5) methyltransferase activity
GTF74_RS03775	COG2912	Transglutaminase-like superfamily
GTF74_RS03780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GTF74_RS03785	COG0737	Belongs to the 5'-nucleotidase family
GTF74_RS03790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTF74_RS03795	COG2233	PERMEase
GTF74_RS03815	COG1393	Belongs to the ArsC family
GTF74_RS03820	COG4783	chaperone-mediated protein folding
GTF74_RS03840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GTF74_RS03855	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GTF74_RS03865	COG1876	peptidase activity
GTF74_RS03875	COG1393	Belongs to the ArsC family
GTF74_RS03895	COG2837	iron assimilation
GTF74_RS03900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF74_RS03905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF74_RS03910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTF74_RS03915	COG1334	flagellar protein FlaG
GTF74_RS03920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GTF74_RS03930	COG1516	flagellar protein fliS
GTF74_RS03940	COG4191	Histidine kinase
GTF74_RS03950	COG1677	Flagellar hook-basal body complex protein FliE
GTF74_RS03960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTF74_RS03965	COG1317	bacterial-type flagellum organization
GTF74_RS03990	COG1580	Controls the rotational direction of flagella during chemotaxis
GTF74_RS04015	COG1987	bacterial-type flagellum assembly
GTF74_RS04020	COG1684	flagellar biosynthetic protein fliR
GTF74_RS04030	COG2840	Smr protein MutS2
GTF74_RS04035	COG2890	protein-(glutamine-N5) methyltransferase activity
GTF74_RS04040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GTF74_RS04045	COG2860	membrane
GTF74_RS04050	COG3101	peptidyl-lysine hydroxylation
GTF74_RS04060	COG0431	NADPH-dependent FMN reductase
GTF74_RS04070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTF74_RS04075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTF74_RS04080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTF74_RS04085	COG0735	belongs to the Fur family
GTF74_RS04095	COG0583	DNA-binding transcription factor activity
GTF74_RS04105	COG1346	cytolysis
GTF74_RS04120	COG0596	Alpha beta hydrolase
GTF74_RS04125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GTF74_RS04130	COG0033	Phosphoglucomutase
GTF74_RS04140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GTF74_RS04145	COG0372	Belongs to the citrate synthase family
GTF74_RS04150	COG2009	succinate dehydrogenase
GTF74_RS04155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GTF74_RS04160	COG1053	succinate dehydrogenase
GTF74_RS04170	COG0567	Dehydrogenase, E1 component
GTF74_RS04175	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTF74_RS04180	COG0045	succinate-CoA ligase (ADP-forming) activity
GTF74_RS04190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTF74_RS04195	COG1121	(ABC) transporter
GTF74_RS04200	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GTF74_RS04205	COG4977	sequence-specific DNA binding
GTF74_RS04210	COG1918	ferrous iron import across plasma membrane
GTF74_RS04230	COG0018	arginyl-trna synthetase
GTF74_RS04240	COG1025	Belongs to the peptidase M16 family
GTF74_RS04245	COG2062	phosphohistidine phosphatase, SixA
GTF74_RS04275	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GTF74_RS04280	COG0643	Histidine kinase
GTF74_RS04280	COG2198	Histidine kinase
GTF74_RS04280	COG0784	Response regulator, receiver
GTF74_RS04285	COG2201	protein-glutamate methylesterase activity
GTF74_RS04290	COG1192	Involved in chromosome partitioning
GTF74_RS04300	COG0835	chemotaxis
GTF74_RS04310	COG4133	protoheme IX ABC transporter activity
GTF74_RS04315	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTF74_RS04320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTF74_RS04330	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GTF74_RS04335	COG1138	Cytochrome C-type biogenesis protein
GTF74_RS04340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTF74_RS04345	COG3088	subunit of a heme lyase
GTF74_RS04345	COG4235	cytochrome complex assembly
GTF74_RS04355	COG2853	Lipoprotein
GTF74_RS04375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GTF74_RS04385	COG0123	including yeast histone deacetylase and acetoin utilization protein
GTF74_RS04400	COG3083	sulfuric ester hydrolase activity
GTF74_RS04405	COG3082	Protein of unknown function (DUF1414)
GTF74_RS04410	COG3081	Nucleoid-associated protein
GTF74_RS04420	COG1757	Na H antiporter
GTF74_RS04425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTF74_RS04430	COG2095	MarC family integral membrane protein
GTF74_RS04435	COG1012	belongs to the aldehyde dehydrogenase family
GTF74_RS04435	COG1454	alcohol dehydrogenase
GTF74_RS04445	COG0659	secondary active sulfate transmembrane transporter activity
GTF74_RS04450	COG1530	ribonuclease E activity
GTF74_RS04455	COG0564	pseudouridine synthase activity
GTF74_RS04460	COG0424	maF-like protein
GTF74_RS04465	COG1399	metal-binding, possibly nucleic acid-binding protein
GTF74_RS04470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GTF74_RS04475	COG0416	fatty acid biosynthetic process
GTF74_RS04480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTF74_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
GTF74_RS04495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTF74_RS04505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTF74_RS04510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GTF74_RS04515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GTF74_RS04525	COG0084	hydrolase, TatD family'
GTF74_RS04530	COG1263	PTS System
GTF74_RS04530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF74_RS04540	COG0733	neurotransmitter:sodium symporter activity
GTF74_RS04565	COG1940	carbohydrate kinase activity
GTF74_RS04570	COG0784	Response regulator, receiver
GTF74_RS04570	COG0835	chemotaxis
GTF74_RS04585	COG2226	methyltransferase
GTF74_RS04595	COG0676	glucose-6-phosphate 1-epimerase activity
GTF74_RS04600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTF74_RS04605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF74_RS04615	COG3139	Protein of unknown function (DUF1315)
GTF74_RS04620	COG0252	asparaginase activity
GTF74_RS04625	COG0616	signal peptide processing
GTF74_RS04630	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTF74_RS04630	COG1902	pentaerythritol trinitrate reductase activity
GTF74_RS04635	COG0788	formyltetrahydrofolate deformylase activity
GTF74_RS04645	COG1199	ATP-dependent helicase activity
GTF74_RS04650	COG1214	PFAM Peptidase M22, glycoprotease
GTF74_RS04665	COG0596	Alpha beta hydrolase
GTF74_RS04670	COG0318	PFAM AMP-dependent synthetase and ligase
GTF74_RS04675	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GTF74_RS04695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GTF74_RS04700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GTF74_RS04705	COG0436	Aminotransferase
GTF74_RS04710	COG1169	isochorismate synthase
GTF74_RS04715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GTF74_RS04720	COG0596	Alpha beta hydrolase
GTF74_RS04740	COG3135	benzoate transporter
GTF74_RS04745	COG1396	sequence-specific DNA binding
GTF74_RS04750	COG0840	transmembrane signaling receptor activity
GTF74_RS04760	COG0477	Major facilitator Superfamily
GTF74_RS04780	COG3015	lipoprotein NlpE involved in copper resistance
GTF74_RS04785	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GTF74_RS04790	COG2894	cell division
GTF74_RS04795	COG0850	regulation of cytokinetic process
GTF74_RS04800	COG3100	YcgL domain-containing protein
GTF74_RS04805	COG2951	lytic endotransglycosylase activity
GTF74_RS04815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTF74_RS04820	COG3325	Belongs to the glycosyl hydrolase 18 family
GTF74_RS04820	COG3469	chitinase activity
GTF74_RS04825	COG3005	denitrification pathway
GTF74_RS04830	COG0243	molybdopterin cofactor binding
GTF74_RS04845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF74_RS04855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GTF74_RS04890	COG4589	Belongs to the CDS family
GTF74_RS04900	COG5001	Diguanylate cyclase
GTF74_RS04900	COG3300	MHYT domain
GTF74_RS04910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GTF74_RS04915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTF74_RS04920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GTF74_RS04925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GTF74_RS04935	COG4191	Histidine kinase
GTF74_RS04945	COG0544	peptidyl-prolyl cis-trans isomerase activity
GTF74_RS04955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GTF74_RS04960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GTF74_RS04965	COG0776	regulation of translation
GTF74_RS04970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTF74_RS04975	COG1555	photosystem II stabilization
GTF74_RS04980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GTF74_RS04985	COG0539	negative regulation of cytoplasmic translation
GTF74_RS04990	COG0776	regulation of translation
GTF74_RS04995	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GTF74_RS05000	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GTF74_RS05020	COG0583	DNA-binding transcription factor activity
GTF74_RS05030	COG0686	Belongs to the AlaDH PNT family
GTF74_RS05040	COG1674	ftsk spoiiie
GTF74_RS05045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GTF74_RS05050	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GTF74_RS05055	COG2186	Transcriptional regulator
GTF74_RS05070	COG0537	adenosine 5'-monophosphoramidase activity
GTF74_RS05095	COG3150	esterase
GTF74_RS05100	COG1252	NADH dehydrogenase
GTF74_RS05120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTF74_RS05130	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTF74_RS05135	COG1136	(ABC) transporter
GTF74_RS05140	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTF74_RS05150	COG2333	competence protein COMEC
GTF74_RS05150	COG0658	competence protein
GTF74_RS05155	COG1132	(ABC) transporter
GTF74_RS05160	COG1663	tetraacyldisaccharide 4'-kinase activity
GTF74_RS05165	COG2835	tetraacyldisaccharide 4'-kinase activity
GTF74_RS05170	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GTF74_RS05175	COG2719	SpoVR family
GTF74_RS05180	COG2718	Belongs to the UPF0229 family
GTF74_RS05185	COG2766	serine protein kinase
GTF74_RS05190	COG3013	Belongs to the UPF0304 family
GTF74_RS05200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GTF74_RS05205	COG0840	transmembrane signaling receptor activity
GTF74_RS05215	COG1882	Formate acetyltransferase
GTF74_RS05240	COG4160	amino acid transport
GTF74_RS05245	COG0708	Exodeoxyribonuclease III
GTF74_RS05250	COG0840	transmembrane signaling receptor activity
GTF74_RS05260	COG3923	Primosomal replication protein n
GTF74_RS05265	COG0730	response to heat
GTF74_RS05270	COG1199	ATP-dependent helicase activity
GTF74_RS05275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTF74_RS05280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GTF74_RS05285	COG3012	SEC-C Motif Domain Protein
GTF74_RS05290	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTF74_RS05295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GTF74_RS05300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTF74_RS05305	COG0215	cysteine-tRNA ligase activity
GTF74_RS05310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GTF74_RS05315	COG0632	four-way junction helicase activity
GTF74_RS05325	COG1271	oxidase subunit
GTF74_RS05330	COG1294	oxidase, subunit
GTF74_RS05335	COG4890	Cyd operon protein YbgT
GTF74_RS05340	COG3790	cyd operon protein YbgE
GTF74_RS05345	COG0824	Thioesterase
GTF74_RS05350	COG0811	peptide transport
GTF74_RS05365	COG0823	Involved in the tonB-independent uptake of proteins
GTF74_RS05370	COG2885	chlorophyll binding
GTF74_RS05380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GTF74_RS05390	COG0784	Response regulator, receiver
GTF74_RS05390	COG5002	protein histidine kinase activity
GTF74_RS05400	COG1482	cell wall glycoprotein biosynthetic process
GTF74_RS05405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF74_RS05405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF74_RS05405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF74_RS05410	COG2207	Transcriptional regulator
GTF74_RS05420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF74_RS05425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF74_RS05430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF74_RS05440	COG1012	belongs to the aldehyde dehydrogenase family
GTF74_RS05445	COG3284	Transcriptional regulator
GTF74_RS05450	COG4628	conserved protein (DUF2132)
GTF74_RS05460	COG0415	Belongs to the DNA photolyase family
GTF74_RS05540	COG0488	(ABC) transporter
GTF74_RS05580	COG3941	tape measure
GTF74_RS05595	COG2003	Belongs to the UPF0758 family
GTF74_RS05605	COG4409	exo-alpha-(2->6)-sialidase activity
GTF74_RS05610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTF74_RS05615	COG1940	carbohydrate kinase activity
GTF74_RS05625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTF74_RS05630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GTF74_RS05635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GTF74_RS05640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTF74_RS05645	COG1737	Transcriptional regulator
GTF74_RS05650	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GTF74_RS05655	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
GTF74_RS05675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GTF74_RS05695	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GTF74_RS05715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTF74_RS05720	COG0582	viral genome integration into host DNA
GTF74_RS05725	COG0582	viral genome integration into host DNA
GTF74_RS05740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF74_RS05750	COG3008	intermembrane lipid transfer
GTF74_RS05750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GTF74_RS05755	COG2995	paraquat-inducible protein a
GTF74_RS05760	COG0668	transmembrane transport
GTF74_RS05780	COG1309	transcriptional regulator
GTF74_RS05785	COG1012	belongs to the aldehyde dehydrogenase family
GTF74_RS05815	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTF74_RS05820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GTF74_RS05845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTF74_RS05850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTF74_RS05855	COG0297	glycogen (starch) synthase activity
GTF74_RS05875	COG3070	regulator of competence-specific genes
GTF74_RS05880	COG1609	Transcriptional regulator
GTF74_RS05885	COG3381	protein complex oligomerization
GTF74_RS05890	COG0745	RESPONSE REGULATOR receiver
GTF74_RS05895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTF74_RS05900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTF74_RS05910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GTF74_RS05930	COG1032	radical SAM domain protein
GTF74_RS05935	COG5001	Diguanylate cyclase
GTF74_RS05940	COG0612	Peptidase, M16
GTF74_RS05955	COG0583	DNA-binding transcription factor activity
GTF74_RS05960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTF74_RS05970	COG2350	Protein conserved in bacteria
GTF74_RS05975	COG1607	acyl-coa hydrolase
GTF74_RS05990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GTF74_RS05995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTF74_RS06005	COG2116	formate transmembrane transporter activity
GTF74_RS06015	COG4459	periplasmic nitrate reductase
GTF74_RS06020	COG3005	denitrification pathway
GTF74_RS06025	COG0243	molybdopterin cofactor binding
GTF74_RS06045	COG1227	inorganic diphosphatase activity
GTF74_RS06060	COG4172	Belongs to the ABC transporter superfamily
GTF74_RS06075	COG4168	peptide transport system, permease
GTF74_RS06085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTF74_RS06090	COG1842	Phage shock protein A
GTF74_RS06105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF74_RS06120	COG2818	Glycosylase
GTF74_RS06125	COG0626	cystathionine gamma-synthase activity
GTF74_RS06135	COG0733	neurotransmitter:sodium symporter activity
GTF74_RS06140	COG0564	pseudouridine synthase activity
GTF74_RS06145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTF74_RS06150	COG4136	ATPase activity
GTF74_RS06155	COG4135	transport system, permease component
GTF74_RS06160	COG4134	Bacterial extracellular solute-binding protein
GTF74_RS06170	COG3313	Fe-S protein
GTF74_RS06180	COG0842	Transport permease protein
GTF74_RS06185	COG1131	(ABC) transporter
GTF74_RS06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF74_RS06195	COG0814	amino acid
GTF74_RS06205	COG2239	Acts as a magnesium transporter
GTF74_RS06210	COG2205	protein histidine kinase activity
GTF74_RS06210	COG0784	Response regulator, receiver
GTF74_RS06225	COG4934	collagen metabolic process
GTF74_RS06255	COG0840	transmembrane signaling receptor activity
GTF74_RS06265	COG2203	Gaf domain
GTF74_RS06265	COG4251	negative regulation of phosphorylation
GTF74_RS06265	COG5001	Diguanylate cyclase
GTF74_RS06265	COG3706	GGDEF domain
GTF74_RS06270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GTF74_RS06290	COG1061	Type III restriction enzyme res subunit
GTF74_RS06295	COG1187	pseudouridine synthase activity
GTF74_RS06300	COG2814	Major facilitator Superfamily
GTF74_RS06310	COG0702	epimerase
GTF74_RS06315	COG0534	Mate efflux family protein
GTF74_RS06320	COG4181	ATPase activity
GTF74_RS06335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GTF74_RS06345	COG1748	Saccharopine dehydrogenase
GTF74_RS06360	COG1538	Outer membrane efflux protein
GTF74_RS06380	COG0583	DNA-binding transcription factor activity
GTF74_RS06390	COG1451	nucleotide metabolic process
GTF74_RS06395	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GTF74_RS06405	COG3063	Type IV pilus biogenesis stability protein PilW
GTF74_RS06410	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GTF74_RS06430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF74_RS06445	COG3290	protein histidine kinase activity
GTF74_RS06450	COG4565	transcriptional regulatory protein
GTF74_RS06460	COG0784	Response regulator, receiver
GTF74_RS06460	COG0835	chemotaxis
GTF74_RS06505	COG1085	galactose-1-phosphate uridylyltransferase
GTF74_RS06510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GTF74_RS06515	COG2017	converts alpha-aldose to the beta-anomer
GTF74_RS06520	COG3706	GGDEF domain
GTF74_RS06525	COG2199	diguanylate cyclase activity
GTF74_RS06525	COG2200	EAL domain
GTF74_RS06540	COG3527	Alpha-acetolactate decarboxylase
GTF74_RS06555	COG0753	catalase activity
GTF74_RS06575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTF74_RS06585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTF74_RS06625	COG1271	oxidase subunit
GTF74_RS06630	COG1294	oxidase, subunit
GTF74_RS06635	COG4591	ABC-type transport system involved in lipoprotein release permease component
GTF74_RS06635	COG1136	(ABC) transporter
GTF74_RS06640	COG0577	efflux transmembrane transporter activity
GTF74_RS06640	COG1136	(ABC) transporter
GTF74_RS06645	COG0577	efflux transmembrane transporter activity
GTF74_RS06645	COG1136	(ABC) transporter
GTF74_RS06665	COG0583	DNA-binding transcription factor activity
GTF74_RS06675	COG2723	6-phospho-beta-galactosidase activity
GTF74_RS06680	COG1609	Transcriptional regulator
GTF74_RS06685	COG0251	oxidation-reduction process
GTF74_RS06690	COG2731	YhcH YjgK YiaL family protein
GTF74_RS06695	COG0584	glycerophosphoryl diester phosphodiesterase
GTF74_RS06700	COG1349	DNA-binding transcription factor activity
GTF74_RS06705	COG3842	ATPase activity
GTF74_RS06710	COG0395	ABC-type sugar transport system, permease component
GTF74_RS06715	COG1175	transmembrane transport
GTF74_RS06730	COG0811	peptide transport
GTF74_RS06735	COG0811	peptide transport
GTF74_RS06740	COG0848	biopolymer transport protein
GTF74_RS06745	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GTF74_RS06755	COG1793	dna ligase
GTF74_RS06765	COG0534	Mate efflux family protein
GTF74_RS06775	COG3001	Fructosamine kinase
GTF74_RS06785	COG0791	NLP P60 protein
GTF74_RS06790	COG0840	transmembrane signaling receptor activity
GTF74_RS06805	COG1940	carbohydrate kinase activity
GTF74_RS06830	COG0746	molybdenum cofactor guanylyltransferase activity
GTF74_RS06835	COG3842	ATPase activity
GTF74_RS06840	COG4662	Binding-protein-dependent transport system inner membrane component
GTF74_RS06850	COG2204	response regulator
GTF74_RS06855	COG3852	Histidine kinase
GTF74_RS06860	COG0488	(ABC) transporter
GTF74_RS06865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GTF74_RS06895	COG3383	formate dehydrogenase (NAD+) activity
GTF74_RS06895	COG0243	molybdopterin cofactor binding
GTF74_RS06900	COG0437	4 iron, 4 sulfur cluster binding
GTF74_RS06915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTF74_RS06920	COG1666	GTP binding
GTF74_RS06925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTF74_RS06940	COG2996	Protein conserved in bacteria
GTF74_RS06950	COG3008	intermembrane lipid transfer
GTF74_RS06955	COG2995	paraquat-inducible protein a
GTF74_RS06960	COG1132	(ABC) transporter
GTF74_RS06965	COG1956	GAF domain-containing protein
GTF74_RS06970	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GTF74_RS06985	COG0308	aminopeptidase N
GTF74_RS07000	COG0167	dihydroorotate dehydrogenase activity
GTF74_RS07010	COG0116	Belongs to the methyltransferase superfamily
GTF74_RS07010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTF74_RS07035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTF74_RS07040	COG1067	ATP-dependent peptidase activity
GTF74_RS07045	COG3120	sequence-specific DNA binding
GTF74_RS07120	COG1476	TRANSCRIPTIONal
GTF74_RS07140	COG1476	TRANSCRIPTIONal
GTF74_RS07170	COG4128	Pfam Zonular occludens toxin
GTF74_RS07185	COG1476	TRANSCRIPTIONal
GTF74_RS07235	COG4128	Pfam Zonular occludens toxin
GTF74_RS07250	COG1476	TRANSCRIPTIONal
GTF74_RS07270	COG1073	alpha beta
GTF74_RS07270	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GTF74_RS07270	COG3064	Membrane
GTF74_RS07275	COG2994	toxin metabolic process
GTF74_RS07300	COG2205	protein histidine kinase activity
GTF74_RS07300	COG0784	Response regulator, receiver
GTF74_RS07315	COG3278	Belongs to the heme-copper respiratory oxidase family
GTF74_RS07330	COG2010	Cytochrome c
GTF74_RS07340	COG2217	Heavy metal translocating P-type atpase
GTF74_RS07355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTF74_RS07360	COG0589	response to stress
GTF74_RS07385	COG3842	ATPase activity
GTF74_RS07395	COG1177	transmembrane transport
GTF74_RS07405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTF74_RS07420	COG1115	amino acid carrier protein
GTF74_RS07425	COG1280	lysine exporter protein (LysE YggA)
GTF74_RS07450	COG3501	Rhs element vgr protein
GTF74_RS07460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GTF74_RS07470	COG2814	Major facilitator Superfamily
GTF74_RS07475	COG1566	PFAM secretion protein HlyD family protein
GTF74_RS07480	COG1538	Outer membrane efflux protein
GTF74_RS07490	COG0513	Belongs to the DEAD box helicase family
GTF74_RS07500	COG0840	transmembrane signaling receptor activity
GTF74_RS07505	COG3290	protein histidine kinase activity
GTF74_RS07505	COG0840	transmembrane signaling receptor activity
GTF74_RS07510	COG0835	chemotaxis
GTF74_RS07515	COG2201	protein-glutamate methylesterase activity
GTF74_RS07525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTF74_RS07530	COG0784	Response regulator, receiver
GTF74_RS07530	COG0643	Histidine kinase
GTF74_RS07530	COG2198	Histidine kinase
GTF74_RS07535	COG2198	Histidine kinase
GTF74_RS07535	COG0643	Histidine kinase
GTF74_RS07545	COG0745	RESPONSE REGULATOR receiver
GTF74_RS07560	COG0415	Belongs to the DNA photolyase family
GTF74_RS07565	COG0477	Major facilitator Superfamily
GTF74_RS07570	COG0583	DNA-binding transcription factor activity
GTF74_RS07580	COG0095	Lipoate-protein ligase
GTF74_RS07585	COG0443	Heat shock 70 kDa protein
GTF74_RS07595	COG1643	Atp-dependent helicase
GTF74_RS07625	COG0443	Heat shock 70 kDa protein
GTF74_RS07630	COG0443	Heat shock 70 kDa protein
GTF74_RS07635	COG3706	GGDEF domain
GTF74_RS07665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GTF74_RS07670	COG0602	queuosine metabolic process
GTF74_RS07675	COG0561	phosphatase activity
GTF74_RS07685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF74_RS07690	COG4597	amino acid ABC transporter
GTF74_RS07695	COG0765	amino acid transport
GTF74_RS07700	COG1126	abc transporter atp-binding protein
GTF74_RS07705	COG0670	Belongs to the BI1 family
GTF74_RS07710	COG2920	part of a sulfur-relay system
GTF74_RS07715	COG1254	Belongs to the acylphosphatase family
GTF74_RS07720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTF74_RS07725	COG3706	GGDEF domain
GTF74_RS07740	COG3437	response regulator, receiver
GTF74_RS07745	COG0625	glutathione transferase activity
GTF74_RS07755	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GTF74_RS07765	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTF74_RS07795	COG0372	Belongs to the citrate synthase family
GTF74_RS07800	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GTF74_RS07840	COG1129	ABC transporter
GTF74_RS07865	COG0745	RESPONSE REGULATOR receiver
GTF74_RS07870	COG2205	protein histidine kinase activity
GTF74_RS07875	COG3713	MltA-interacting MipA family protein
GTF74_RS07880	COG2990	Protein conserved in bacteria
GTF74_RS07890	COG4191	Histidine kinase
GTF74_RS07890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF74_RS07895	COG0471	metal ion transport
GTF74_RS07905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTF74_RS07920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF74_RS07930	COG3768	UPF0283 membrane protein
GTF74_RS07935	COG3106	COG3106 Predicted ATPase
GTF74_RS07950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTF74_RS07955	COG0494	nUDIX hydrolase
GTF74_RS07960	COG0814	amino acid
GTF74_RS07965	COG1760	l-serine dehydratase
GTF74_RS07970	COG0720	synthase
GTF74_RS07980	COG0017	Asparaginyl-tRNA synthetase
GTF74_RS07985	COG0351	phosphomethylpyrimidine kinase
GTF74_RS07990	COG2770	Histidine kinase
GTF74_RS07990	COG3437	response regulator, receiver
GTF74_RS07995	COG1448	Aminotransferase
GTF74_RS08010	COG0840	transmembrane signaling receptor activity
GTF74_RS08015	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GTF74_RS08020	COG2943	transferase activity, transferring hexosyl groups
GTF74_RS08025	COG1609	Transcriptional regulator
GTF74_RS08035	COG1486	melibiose metabolic process
GTF74_RS08040	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTF74_RS08050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTF74_RS08055	COG0726	polysaccharide deacetylase
GTF74_RS08060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTF74_RS08065	COG1846	Transcriptional regulator
GTF74_RS08090	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GTF74_RS08105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTF74_RS08110	COG3108	Peptidase M15
GTF74_RS08115	COG2989	Protein conserved in bacteria
GTF74_RS08140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTF74_RS08150	COG2814	Major facilitator Superfamily
GTF74_RS08170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTF74_RS08175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTF74_RS08180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTF74_RS08230	COG4139	cobalamin transport
GTF74_RS08250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GTF74_RS08255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GTF74_RS08260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF74_RS08270	COG2925	Exonuclease
GTF74_RS08275	COG1380	Effector of murein hydrolase LrgA
GTF74_RS08280	COG1346	cytolysis
GTF74_RS08310	COG0776	regulation of translation
GTF74_RS08315	COG0072	phenylalanine-tRNA ligase activity
GTF74_RS08315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF74_RS08320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GTF74_RS08360	COG0322	excinuclease ABC activity
GTF74_RS08365	COG2197	response regulator
GTF74_RS08370	COG0417	DNA replication proofreading
GTF74_RS08375	COG5001	Diguanylate cyclase
GTF74_RS08385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTF74_RS08390	COG3099	Belongs to the UPF0263 family
GTF74_RS08405	COG1228	amidohydrolase
GTF74_RS08410	COG0010	Belongs to the arginase family
GTF74_RS08415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GTF74_RS08420	COG2986	histidine ammonia-lyase
GTF74_RS08440	COG0247	lactate metabolic process
GTF74_RS08440	COG0277	FAD linked oxidase domain protein
GTF74_RS08455	COG2885	chlorophyll binding
GTF74_RS08475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GTF74_RS08485	COG0281	malic enzyme
GTF74_RS08495	COG2949	membrane
GTF74_RS08500	COG3706	GGDEF domain
GTF74_RS08505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTF74_RS08515	COG0492	ferredoxin-NADP+ reductase activity
GTF74_RS08520	COG4988	ABC transporter
GTF74_RS08525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GTF74_RS08530	COG1187	pseudouridine synthase activity
GTF74_RS08535	COG0009	L-threonylcarbamoyladenylate synthase
GTF74_RS08540	COG0613	PHP domain protein
GTF74_RS08550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTF74_RS08555	COG0512	Glutamine amidotransferase of anthranilate synthase
GTF74_RS08560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GTF74_RS08565	COG0134	indole-3-glycerol-phosphate synthase activity
GTF74_RS08565	COG0135	phosphoribosylanthranilate isomerase activity
GTF74_RS08570	COG0133	tryptophan synthase activity
GTF74_RS08575	COG0159	tryptophan synthase activity
GTF74_RS08585	COG1435	thymidine kinase activity
GTF74_RS08590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GTF74_RS08595	COG1801	Protein of unknown function DUF72
GTF74_RS08600	COG4106	trans-aconitate 2-methyltransferase activity
GTF74_RS08605	COG0500	methyltransferase
GTF74_RS08610	COG0189	ligase activity
GTF74_RS08610	COG4067	protein conserved in archaea
GTF74_RS08625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GTF74_RS08635	COG3852	Histidine kinase
GTF74_RS08650	COG3070	regulator of competence-specific genes
GTF74_RS08660	COG2431	L-lysine efflux transmembrane transporter activity
GTF74_RS08670	COG0076	glutamate decarboxylase activity
GTF74_RS08675	COG1737	Transcriptional regulator
GTF74_RS08680	COG1454	alcohol dehydrogenase
GTF74_RS08680	COG1012	belongs to the aldehyde dehydrogenase family
GTF74_RS08685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTF74_RS08690	COG3273	potassium ion transport
GTF74_RS08690	COG2985	domain, Protein
GTF74_RS08695	COG0542	response to heat
GTF74_RS08700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GTF74_RS08705	COG1278	Cold shock
GTF74_RS08715	COG1187	pseudouridine synthase activity
GTF74_RS08720	COG0140	phosphoribosyl-ATP diphosphatase activity
GTF74_RS08720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GTF74_RS08725	COG0107	imidazoleglycerol-phosphate synthase activity
GTF74_RS08730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GTF74_RS08735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GTF74_RS08740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GTF74_RS08740	COG0131	Imidazoleglycerol-phosphate dehydratase
GTF74_RS08745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GTF74_RS08750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GTF74_RS08755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GTF74_RS08760	COG1757	Na H antiporter
GTF74_RS08765	COG2916	Histone family protein nucleoid-structuring protein H-NS
GTF74_RS08770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF74_RS08775	COG0482	sulfurtransferase activity
GTF74_RS08780	COG2915	High frequency lysogenization protein hflD homolog
GTF74_RS08785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTF74_RS08795	COG2268	Band 7 protein
GTF74_RS08805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTF74_RS08820	COG0300	oxidoreductase activity
GTF74_RS08830	COG0501	Belongs to the peptidase M48B family
GTF74_RS08840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GTF74_RS08845	COG2226	methyltransferase
GTF74_RS08850	COG0156	8-amino-7-oxononanoate synthase activity
GTF74_RS08855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTF74_RS08860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTF74_RS08865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GTF74_RS08870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTF74_RS08875	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GTF74_RS08885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTF74_RS08890	COG2199	diguanylate cyclase activity
GTF74_RS08890	COG2203	Gaf domain
GTF74_RS08900	COG4120	Belongs to the binding-protein-dependent transport system permease family
GTF74_RS08910	COG4628	conserved protein (DUF2132)
GTF74_RS08915	COG3092	negative regulation of chromosome organization
GTF74_RS08920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTF74_RS08925	COG0857	belongs to the CobB CobQ family
GTF74_RS08925	COG0280	phosphate acetyltransferase
GTF74_RS08930	COG0435	Glutathione S-transferase
GTF74_RS08935	COG4608	Belongs to the ABC transporter superfamily
GTF74_RS08940	COG0444	Belongs to the ABC transporter superfamily
GTF74_RS08945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF74_RS08950	COG0601	transmembrane transport
GTF74_RS08970	COG2204	response regulator
GTF74_RS08975	COG5001	Diguanylate cyclase
GTF74_RS08975	COG3300	MHYT domain
GTF74_RS08980	COG4191	Histidine kinase
GTF74_RS08985	COG5002	protein histidine kinase activity
GTF74_RS08995	COG2201	protein-glutamate methylesterase activity
GTF74_RS09010	COG0009	L-threonylcarbamoyladenylate synthase
GTF74_RS09025	COG1881	PFAM PEBP family protein
GTF74_RS09050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTF74_RS09055	COG0640	Transcriptional regulator
GTF74_RS09065	COG3706	GGDEF domain
GTF74_RS09085	COG1946	Acyl-CoA thioesterase
GTF74_RS09090	COG1522	sequence-specific DNA binding
GTF74_RS09100	COG0616	signal peptide processing
GTF74_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
GTF74_RS09110	COG2983	Belongs to the UPF0260 family
GTF74_RS09120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GTF74_RS09125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GTF74_RS09135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTF74_RS09140	COG2832	Protein of unknown function (DUF454)
GTF74_RS09145	COG0745	RESPONSE REGULATOR receiver
GTF74_RS09150	COG0583	DNA-binding transcription factor activity
GTF74_RS09155	COG0778	Nitroreductase
GTF74_RS09160	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTF74_RS09160	COG1024	Enoyl-CoA hydratase
GTF74_RS09165	COG0183	Belongs to the thiolase family
GTF74_RS09180	COG2067	long-chain fatty acid transport protein
GTF74_RS09190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTF74_RS09195	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GTF74_RS09200	COG2982	Protein involved in outer membrane biogenesis
GTF74_RS09205	COG0572	uridine kinase
GTF74_RS09210	COG0489	protein tyrosine kinase activity
GTF74_RS09215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF74_RS09215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTF74_RS09225	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GTF74_RS09235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GTF74_RS09235	COG0617	tRNA 3'-terminal CCA addition
GTF74_RS09235	COG0517	IMP dehydrogenase activity
GTF74_RS09240	COG2199	diguanylate cyclase activity
GTF74_RS09245	COG0314	molybdopterin synthase activity
GTF74_RS09250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GTF74_RS09255	COG0315	cyclic pyranopterin monophosphate synthase activity
GTF74_RS09260	COG0521	Mo-molybdopterin cofactor biosynthetic process
GTF74_RS09265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GTF74_RS09270	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GTF74_RS09275	COG2198	Histidine kinase
GTF74_RS09280	COG2204	response regulator
GTF74_RS09285	COG0556	nucleotide-excision repair
GTF74_RS09295	COG4657	Part of a membrane complex involved in electron transport
GTF74_RS09300	COG2878	Part of a membrane complex involved in electron transport
GTF74_RS09305	COG4656	Part of a membrane complex involved in electron transport
GTF74_RS09325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTF74_RS09330	COG0346	lactoylglutathione lyase activity
GTF74_RS09345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTF74_RS09350	COG2056	Na+-H+ antiporter family
GTF74_RS09355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GTF74_RS09360	COG1286	toxin biosynthetic process
GTF74_RS09365	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GTF74_RS09370	COG0285	dihydrofolate synthase activity
GTF74_RS09375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GTF74_RS09380	COG0101	tRNA pseudouridine synthase activity
GTF74_RS09395	COG1263	PTS System
GTF74_RS09395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF74_RS09395	COG2190	(PTS) system
GTF74_RS09400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTF74_RS09405	COG1940	carbohydrate kinase activity
GTF74_RS09405	COG1846	Transcriptional regulator
GTF74_RS09410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTF74_RS09410	COG4651	solute:proton antiporter activity
GTF74_RS09415	COG0367	asparagine synthase
GTF74_RS09430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GTF74_RS09435	COG0563	adenylate kinase activity
GTF74_RS09440	COG0326	Molecular chaperone. Has ATPase activity
GTF74_RS09445	COG3710	Transcriptional regulator
GTF74_RS09460	COG0622	Phosphoesterase
GTF74_RS09465	COG1090	epimerase
GTF74_RS09470	COG0300	oxidoreductase activity
GTF74_RS09475	COG3118	belongs to the thioredoxin family
GTF74_RS09480	COG0330	HflC and HflK could
GTF74_RS09485	COG1585	Membrane protein implicated in regulation of membrane protease activity
GTF74_RS09490	COG0789	Transcriptional regulator
GTF74_RS09505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GTF74_RS09510	COG3115	cell septum assembly
GTF74_RS09515	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GTF74_RS09520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTF74_RS09525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF74_RS09535	COG2190	(PTS) system
GTF74_RS09540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTF74_RS09545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTF74_RS09550	COG1702	phosphate starvation-inducible protein PhoH
GTF74_RS09560	COG4535	Mg2 and Co2 transporter CorC
GTF74_RS09565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GTF74_RS09570	COG2888	peptidyl-tyrosine sulfation
GTF74_RS09575	COG0495	leucyl-tRNA aminoacylation
GTF74_RS09580	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GTF74_RS09585	COG1466	dna polymerase III delta subunit
GTF74_RS09590	COG0799	negative regulation of ribosome biogenesis
GTF74_RS09595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GTF74_RS09600	COG0768	penicillin binding
GTF74_RS09605	COG0772	Belongs to the SEDS family
GTF74_RS09610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTF74_RS09615	COG1686	Belongs to the peptidase S11 family
GTF74_RS09620	COG2921	Belongs to the UPF0250 family
GTF74_RS09625	COG0321	lipoyl(octanoyl) transferase activity
GTF74_RS09630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GTF74_RS09640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTF74_RS09665	COG1596	polysaccharide export
GTF74_RS09675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTF74_RS09705	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GTF74_RS09715	COG0438	transferase activity, transferring glycosyl groups
GTF74_RS09725	COG1045	serine acetyltransferase
GTF74_RS09745	COG0110	maltose O-acetyltransferase activity
GTF74_RS09750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GTF74_RS09755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTF74_RS09760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTF74_RS09765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTF74_RS09795	COG0366	Alpha amylase catalytic
GTF74_RS09800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF74_RS09800	COG1263	PTS System
GTF74_RS09805	COG1609	Transcriptional regulator
GTF74_RS09810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GTF74_RS09815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTF74_RS09820	COG2011	ABC-type metal ion transport system permease component
GTF74_RS09825	COG1464	Belongs to the NlpA lipoprotein family
GTF74_RS09830	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GTF74_RS09840	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTF74_RS09840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTF74_RS09850	COG3706	GGDEF domain
GTF74_RS09855	COG1611	Belongs to the LOG family
GTF74_RS09860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTF74_RS09865	COG2363	Small membrane protein
GTF74_RS09870	COG0583	DNA-binding transcription factor activity
GTF74_RS09875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTF74_RS09875	COG0301	tRNA thio-modification
GTF74_RS09885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GTF74_RS09890	COG1722	exodeoxyribonuclease VII activity
GTF74_RS09895	COG0142	geranyltranstransferase activity
GTF74_RS09900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GTF74_RS09905	COG0564	pseudouridine synthase activity
GTF74_RS09910	COG3098	single-species biofilm formation
GTF74_RS09925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF74_RS09935	COG1671	Belongs to the UPF0178 family
GTF74_RS09940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GTF74_RS09945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTF74_RS09950	COG0254	rRNA binding
GTF74_RS09955	COG1720	tRNA m6t6A37 methyltransferase activity
GTF74_RS09960	COG0442	prolyl-tRNA aminoacylation
GTF74_RS09985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTF74_RS09985	COG0047	phosphoribosylformylglycinamidine synthase activity
GTF74_RS09995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GTF74_RS10005	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GTF74_RS10035	COG0484	heat shock protein binding
GTF74_RS10040	COG0443	Heat shock 70 kDa protein
GTF74_RS10050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GTF74_RS10055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTF74_RS10060	COG0497	DNA recombination
GTF74_RS10065	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTF74_RS10070	COG2914	Belongs to the UPF0125 (RnfH) family
GTF74_RS10075	COG2867	negative regulation of translational initiation
GTF74_RS10080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GTF74_RS10090	COG0582	viral genome integration into host DNA
GTF74_RS10100	COG0582	viral genome integration into host DNA
GTF74_RS10105	COG3064	Membrane
GTF74_RS10115	COG0739	heme binding
GTF74_RS10135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GTF74_RS10140	COG2207	Transcriptional regulator
GTF74_RS10150	COG1459	type II secretion system
GTF74_RS10155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF74_RS10175	COG4796	Type ii and iii secretion system protein
GTF74_RS10190	COG2165	general secretion pathway protein
GTF74_RS10200	COG3710	Transcriptional regulator
GTF74_RS10205	COG0840	transmembrane signaling receptor activity
GTF74_RS10210	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTF74_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
GTF74_RS10285	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GTF74_RS10290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GTF74_RS10295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTF74_RS10315	COG3051	citrate lyase alpha subunit
GTF74_RS10320	COG2301	Belongs to the HpcH HpaI aldolase family
GTF74_RS10330	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GTF74_RS10340	COG3630	sodium ion export across plasma membrane
GTF74_RS10345	COG5016	pyruvate
GTF74_RS10345	COG0511	ligase activity, forming carbon-carbon bonds
GTF74_RS10350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GTF74_RS10360	COG4565	transcriptional regulatory protein
GTF74_RS10375	COG0583	DNA-binding transcription factor activity
GTF74_RS10385	COG1115	amino acid carrier protein
GTF74_RS10390	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GTF74_RS10395	COG0583	DNA-binding transcription factor activity
GTF74_RS10405	COG1120	ATPase activity
GTF74_RS10410	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF74_RS10415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF74_RS10420	COG4592	Periplasmic binding protein
GTF74_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
GTF74_RS10435	COG1169	isochorismate synthase
GTF74_RS10440	COG1021	2,3-dihydroxybenzoate-AMP ligase
GTF74_RS10445	COG1535	isochorismatase
GTF74_RS10445	COG3433	isochorismatase activity
GTF74_RS10450	COG1584	GPR1 FUN34 yaaH family protein
GTF74_RS10460	COG0519	Catalyzes the synthesis of GMP from XMP
GTF74_RS10460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GTF74_RS10465	COG0517	IMP dehydrogenase activity
GTF74_RS10465	COG0516	GMP reductase activity
GTF74_RS10470	COG1570	exodeoxyribonuclease VII activity
GTF74_RS10485	COG1160	GTP binding
GTF74_RS10490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTF74_RS10495	COG2976	Protein conserved in bacteria
GTF74_RS10500	COG0124	histidyl-tRNA synthetase
GTF74_RS10505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GTF74_RS10515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GTF74_RS10520	COG0105	UTP biosynthetic process
GTF74_RS10525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTF74_RS10530	COG2975	iron-sulfur cluster assembly
GTF74_RS10535	COG0633	Ferredoxin
GTF74_RS10540	COG0443	Heat shock 70 kDa protein
GTF74_RS10545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GTF74_RS10555	COG0822	iron-sulfur transferase activity
GTF74_RS10560	COG1104	cysteine desulfurase activity
GTF74_RS10565	COG1959	2 iron, 2 sulfur cluster binding
GTF74_RS10575	COG0483	inositol monophosphate 1-phosphatase activity
GTF74_RS10580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF74_RS10585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF74_RS10590	COG1862	Preprotein translocase
GTF74_RS10605	COG0517	IMP dehydrogenase activity
GTF74_RS10615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GTF74_RS10620	COG0583	DNA-binding transcription factor activity
GTF74_RS10625	COG0450	alkyl hydroperoxide reductase
GTF74_RS10630	COG3142	Participates in the control of copper homeostasis
GTF74_RS10645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTF74_RS10650	COG0581	inorganic phosphate transmembrane transporter activity
GTF74_RS10660	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GTF74_RS10665	COG0248	Ppx GppA phosphatase
GTF74_RS10675	COG5002	protein histidine kinase activity
GTF74_RS10680	COG0745	RESPONSE REGULATOR receiver
GTF74_RS10695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTF74_RS10735	COG0542	response to heat
GTF74_RS10745	COG0564	pseudouridine synthase activity
GTF74_RS10750	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTF74_RS10755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTF74_RS10760	COG0077	Prephenate dehydratase
GTF74_RS10760	COG1605	Chorismate mutase
GTF74_RS10765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GTF74_RS10770	COG5001	Diguanylate cyclase
GTF74_RS10780	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GTF74_RS10790	COG0488	(ABC) transporter
GTF74_RS10800	COG0287	Prephenate dehydrogenase
GTF74_RS10800	COG1605	Chorismate mutase
GTF74_RS10805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTF74_RS10810	COG3275	phosphorelay sensor kinase activity
GTF74_RS10815	COG3279	Response regulator of the LytR AlgR family
GTF74_RS10825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GTF74_RS10830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTF74_RS10845	COG1966	Carbon starvation protein
GTF74_RS10850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GTF74_RS10855	COG1047	Peptidyl-prolyl cis-trans
GTF74_RS10870	COG0196	riboflavin kinase activity
GTF74_RS10875	COG0728	peptidoglycan biosynthetic process
GTF74_RS10880	COG0268	Binds directly to 16S ribosomal RNA
GTF74_RS10885	COG0640	Transcriptional regulator
GTF74_RS10890	COG0583	DNA-binding transcription factor activity
GTF74_RS10895	COG1283	sodium-dependent phosphate transmembrane transporter activity
GTF74_RS10905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GTF74_RS10910	COG0730	response to heat
GTF74_RS10915	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GTF74_RS10920	COG0494	nUDIX hydrolase
GTF74_RS10930	COG0667	Aldo Keto reductase
GTF74_RS10940	COG2204	response regulator
GTF74_RS10945	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GTF74_RS10965	COG0513	Belongs to the DEAD box helicase family
GTF74_RS10990	COG3153	acetyltransferase
GTF74_RS10995	COG3154	lipid carrier protein
GTF74_RS11005	COG0826	peptidase U32
GTF74_RS11010	COG0826	peptidase U32
GTF74_RS11035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GTF74_RS11045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GTF74_RS11050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GTF74_RS11055	COG0195	Participates in both transcription termination and antitermination
GTF74_RS11060	COG0779	Required for maturation of 30S ribosomal subunits
GTF74_RS11075	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTF74_RS11085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GTF74_RS11090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GTF74_RS11095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GTF74_RS11100	COG1534	Rna-binding protein
GTF74_RS11105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTF74_RS11110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTF74_RS11115	COG2027	D-alanyl-D-alanine carboxypeptidase
GTF74_RS11120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTF74_RS11125	COG0739	heme binding
GTF74_RS11140	COG0316	Belongs to the HesB IscA family
GTF74_RS11145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTF74_RS11150	COG0628	permease
GTF74_RS11155	COG2813	Specifically methylates the guanine in position
GTF74_RS11160	COG2205	protein histidine kinase activity
GTF74_RS11160	COG0784	Response regulator, receiver
GTF74_RS11165	COG0747	negative chemotaxis
GTF74_RS11170	COG0601	transmembrane transport
GTF74_RS11175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF74_RS11180	COG0444	Belongs to the ABC transporter superfamily
GTF74_RS11185	COG4608	Belongs to the ABC transporter superfamily
GTF74_RS11195	COG2971	BadF BadG BcrA BcrD
GTF74_RS11215	COG3842	ATPase activity
GTF74_RS11225	COG1840	ABC-type Fe3 transport system, periplasmic component
GTF74_RS11230	COG0004	ammonium transporteR
GTF74_RS11235	COG0347	Belongs to the P(II) protein family
GTF74_RS11240	COG3112	Uncharacterised protein family (UPF0231)
GTF74_RS11245	COG1049	propionate catabolic process, 2-methylcitrate cycle
GTF74_RS11250	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTF74_RS11255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTF74_RS11260	COG1643	Atp-dependent helicase
GTF74_RS11270	COG1489	DNA binding
GTF74_RS11280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTF74_RS11290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTF74_RS11295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GTF74_RS11300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GTF74_RS11305	COG0842	Transport permease protein
GTF74_RS11310	COG1131	(ABC) transporter
GTF74_RS11315	COG0659	secondary active sulfate transmembrane transporter activity
GTF74_RS11320	COG0288	reversible hydration of carbon dioxide
GTF74_RS11335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GTF74_RS11340	COG3107	peptidoglycan biosynthetic process
GTF74_RS11345	COG0792	nuclease activity
GTF74_RS11350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GTF74_RS11355	COG2823	Periplasmic or secreted lipoprotein
GTF74_RS11360	COG2969	positive regulation of protein catabolic process
GTF74_RS11365	COG0625	glutathione transferase activity
GTF74_RS11370	COG2857	Cytochrome c1
GTF74_RS11375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GTF74_RS11380	COG0723	plastoquinol--plastocyanin reductase activity
GTF74_RS11385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GTF74_RS11390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GTF74_RS11395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GTF74_RS11405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTF74_RS11410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTF74_RS11415	COG0335	large ribosomal subunit rRNA binding
GTF74_RS11420	COG0336	Belongs to the RNA methyltransferase TrmD family
GTF74_RS11425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GTF74_RS11430	COG0228	four-way junction DNA binding
GTF74_RS11435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTF74_RS11440	COG4137	Cytochrome C assembly protein
GTF74_RS11445	COG4536	flavin adenine dinucleotide binding
GTF74_RS11450	COG1854	S-ribosylhomocysteine lyase activity
GTF74_RS11455	COG2918	glutathione biosynthetic process
GTF74_RS11460	COG0612	Peptidase, M16
GTF74_RS11465	COG1238	metal cluster binding
GTF74_RS11475	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GTF74_RS11480	COG5016	pyruvate
GTF74_RS11480	COG0511	ligase activity, forming carbon-carbon bonds
GTF74_RS11485	COG3630	sodium ion export across plasma membrane
GTF74_RS11530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GTF74_RS11535	COG0527	aspartate kinase activity
GTF74_RS11540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTF74_RS11550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GTF74_RS11560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GTF74_RS11565	COG4208	sulfate ABC transporter
GTF74_RS11585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GTF74_RS11590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTF74_RS11600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GTF74_RS11605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GTF74_RS11610	COG0585	pseudouridine synthase activity
GTF74_RS11615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GTF74_RS11620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GTF74_RS11625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GTF74_RS11630	COG1968	undecaprenyl-diphosphatase activity
GTF74_RS11635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTF74_RS11640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTF74_RS11645	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTF74_RS11655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GTF74_RS11660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTF74_RS11665	COG1610	YqeY-like protein
GTF74_RS11670	COG0358	DNA primase activity
GTF74_RS11685	COG0582	viral genome integration into host DNA
GTF74_RS11690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTF74_RS11700	COG2207	Transcriptional regulator
GTF74_RS11705	COG0840	transmembrane signaling receptor activity
GTF74_RS11715	COG2003	Belongs to the UPF0758 family
GTF74_RS11745	COG0739	heme binding
GTF74_RS11755	COG4969	Belongs to the N-Me-Phe pilin family
GTF74_RS11770	COG0328	RNA-DNA hybrid ribonuclease activity
GTF74_RS11820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GTF74_RS11825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTF74_RS11830	COG1349	DNA-binding transcription factor activity
GTF74_RS11850	COG1279	arginine transmembrane transporter activity
GTF74_RS11855	COG0668	transmembrane transport
GTF74_RS11860	COG0191	fructose-bisphosphate aldolase activity
GTF74_RS11865	COG0126	phosphoglycerate kinase activity
GTF74_RS11870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTF74_RS11875	COG4771	TonB-dependent receptor
GTF74_RS11880	COG0583	DNA-binding transcription factor activity
GTF74_RS11885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTF74_RS11890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GTF74_RS11900	COG2356	endonuclease I
GTF74_RS11905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GTF74_RS11910	COG0189	ligase activity
GTF74_RS11915	COG1678	Uncharacterized ACR, COG1678
GTF74_RS11920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GTF74_RS11925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTF74_RS11945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GTF74_RS11950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTF74_RS11955	COG0762	integral membrane protein
GTF74_RS11960	COG1872	DUF167
GTF74_RS11970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTF74_RS11975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTF74_RS11980	COG2066	Belongs to the glutaminase family
GTF74_RS11990	COG1194	a g-specific adenine glycosylase
GTF74_RS11995	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GTF74_RS12000	COG0741	lytic transglycosylase activity
GTF74_RS12055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GTF74_RS12060	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GTF74_RS12065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTF74_RS12070	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GTF74_RS12075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GTF74_RS12080	COG2967	ApaG domain
GTF74_RS12085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GTF74_RS12095	COG3610	response to peptide
GTF74_RS12100	COG2966	Psort location CytoplasmicMembrane, score
GTF74_RS12105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GTF74_RS12110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GTF74_RS12115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GTF74_RS12120	COG0142	geranyltranstransferase activity
GTF74_RS12125	COG0531	amino acid
GTF74_RS12130	COG0039	L-malate dehydrogenase activity
GTF74_RS12135	COG1438	arginine binding
GTF74_RS12140	COG2358	TRAP transporter, solute receptor (TAXI family
GTF74_RS12150	COG0589	response to stress
GTF74_RS12170	COG2235	arginine
GTF74_RS12175	COG0312	modulator of DNA gyrase
GTF74_RS12180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTF74_RS12185	COG3164	Protein of unknown function
GTF74_RS12190	COG1530	ribonuclease E activity
GTF74_RS12195	COG0424	maF-like protein
GTF74_RS12200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GTF74_RS12205	COG1792	Involved in formation and maintenance of cell shape
GTF74_RS12210	COG1077	Cell shape determining protein MreB Mrl
GTF74_RS12255	COG1459	type II secretion system
GTF74_RS12260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTF74_RS12270	COG3409	Peptidoglycan-binding domain 1 protein
GTF74_RS12270	COG3267	Type II secretory pathway component ExeA
GTF74_RS12295	COG2199	diguanylate cyclase activity
GTF74_RS12295	COG2200	EAL domain
GTF74_RS12300	COG0629	single-stranded DNA binding
GTF74_RS12315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTF74_RS12325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTF74_RS12330	COG0527	aspartate kinase activity
GTF74_RS12335	COG1410	methionine synthase
GTF74_RS12335	COG0646	methionine synthase
GTF74_RS12405	COG0175	sulfate reduction
GTF74_RS12415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTF74_RS12440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTF74_RS12445	COG0735	belongs to the Fur family
GTF74_RS12465	COG0432	Pfam Uncharacterised protein family UPF0047
GTF74_RS12470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTF74_RS12485	COG0359	binds to the 23S rRNA
GTF74_RS12490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTF74_RS12495	COG2965	DNA replication, synthesis of RNA primer
GTF74_RS12500	COG0360	Binds together with S18 to 16S ribosomal RNA
GTF74_RS12510	COG2906	2 iron, 2 sulfur cluster binding
GTF74_RS12515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTF74_RS12520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTF74_RS12525	COG0049	tRNA binding
GTF74_RS12530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GTF74_RS12540	COG2923	Belongs to the DsrF TusC family
GTF74_RS12545	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GTF74_RS12550	COG2964	Protein conserved in bacteria
GTF74_RS12565	COG2900	Belongs to the SlyX family
GTF74_RS12570	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GTF74_RS12575	COG0330	HflC and HflK could
GTF74_RS12580	COG0330	HflC and HflK could
GTF74_RS12585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTF74_RS12590	COG1923	regulation of RNA biosynthetic process
GTF74_RS12595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GTF74_RS12600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GTF74_RS12610	COG0802	atpase or kinase
GTF74_RS12615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GTF74_RS12660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GTF74_RS12665	COG1162	GTPase activity
GTF74_RS12670	COG0688	phosphatidylethanolamine metabolic process
GTF74_RS12675	COG0471	metal ion transport
GTF74_RS12685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GTF74_RS12705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GTF74_RS12710	COG2816	NAD+ diphosphatase activity
GTF74_RS12715	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GTF74_RS12720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GTF74_RS12725	COG0085	RNA polymerase activity
GTF74_RS12730	COG0222	ribosome binding
GTF74_RS12735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GTF74_RS12745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GTF74_RS12750	COG0250	Participates in transcription elongation, termination and antitermination
GTF74_RS12755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTF74_RS12760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTF74_RS12785	COG1072	(Pantothenic acid kinase))
GTF74_RS12795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTF74_RS12805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTF74_RS12850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GTF74_RS12865	COG3118	belongs to the thioredoxin family
GTF74_RS12870	COG0513	Belongs to the DEAD box helicase family
GTF74_RS12875	COG0248	Ppx GppA phosphatase
GTF74_RS12880	COG2205	protein histidine kinase activity
GTF74_RS12880	COG0784	Response regulator, receiver
GTF74_RS12885	COG2814	Major facilitator Superfamily
GTF74_RS12900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTF74_RS12905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GTF74_RS12910	COG0511	ligase activity, forming carbon-carbon bonds
GTF74_RS12915	COG0439	Biotin carboxylase
GTF74_RS12920	COG2264	protein methyltransferase activity
GTF74_RS12925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTF74_RS12930	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GTF74_RS12935	COG1609	Transcriptional regulator
GTF74_RS12940	COG0129	dihydroxy-acid dehydratase activity
GTF74_RS12945	COG3265	gluconokinase activity
GTF74_RS12955	COG0800	Aldolase
GTF74_RS12975	COG0840	transmembrane signaling receptor activity
GTF74_RS12980	COG1982	Orn Lys Arg decarboxylase major
GTF74_RS12985	COG0531	amino acid
GTF74_RS12990	COG3710	Transcriptional regulator
GTF74_RS12995	COG0789	Transcriptional regulator
GTF74_RS13010	COG0151	Belongs to the GarS family
GTF74_RS13020	COG0776	regulation of translation
GTF74_RS13025	COG1253	flavin adenine dinucleotide binding
GTF74_RS13030	COG1940	carbohydrate kinase activity
GTF74_RS13040	COG3068	Protein conserved in bacteria
GTF74_RS13050	COG1573	uracil-dna glycosylase
GTF74_RS13055	COG0668	transmembrane transport
GTF74_RS13060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GTF74_RS13065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTF74_RS13110	COG1454	alcohol dehydrogenase
GTF74_RS13110	COG1012	belongs to the aldehyde dehydrogenase family
GTF74_RS13115	COG0318	PFAM AMP-dependent synthetase and ligase
GTF74_RS13145	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GTF74_RS13150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTF74_RS13155	COG0662	Cupin 2, conserved barrel domain protein
GTF74_RS13155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GTF74_RS13160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTF74_RS13195	COG1519	Transferase
GTF74_RS13225	COG3642	lipopolysaccharide core region biosynthetic process
GTF74_RS13230	COG0859	PFAM glycosyl transferase family 9
GTF74_RS13235	COG0463	Glycosyl transferase, family 2
GTF74_RS13240	COG0859	PFAM glycosyl transferase family 9
GTF74_RS13245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GTF74_RS13250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GTF74_RS13260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTF74_RS13265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GTF74_RS13270	COG2003	Belongs to the UPF0758 family
GTF74_RS13280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTF74_RS13290	COG1309	transcriptional regulator
GTF74_RS13295	COG1560	Kdo2-lipid A biosynthetic process
GTF74_RS13300	COG1560	Kdo2-lipid A biosynthetic process
GTF74_RS13305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GTF74_RS13310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GTF74_RS13315	COG1561	YicC-like family, N-terminal region
GTF74_RS13320	COG2862	Uncharacterized protein family, UPF0114
GTF74_RS13325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF74_RS13325	COG1263	PTS System
GTF74_RS13330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTF74_RS13350	COG1120	ATPase activity
GTF74_RS13355	COG4774	siderophore transport
GTF74_RS13360	COG1132	(ABC) transporter
GTF74_RS13375	COG0514	ATP-dependent DNA helicase (RecQ)
GTF74_RS13380	COG2962	Rard protein
GTF74_RS13395	COG1280	lysine exporter protein (LysE YggA)
GTF74_RS13400	COG0210	DNA helicase
GTF74_RS13410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GTF74_RS13415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTF74_RS13455	COG3621	Patatin-like phospholipase
GTF74_RS13480	COG2131	deaminase
GTF74_RS13490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF74_RS13500	COG0747	negative chemotaxis
GTF74_RS13550	COG1309	transcriptional regulator
GTF74_RS13555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTF74_RS13560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTF74_RS13565	COG2960	long-chain fatty acid transporting porin activity
GTF74_RS13570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GTF74_RS13575	COG0583	DNA-binding transcription factor activity
GTF74_RS13620	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GTF74_RS13625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTF74_RS13630	COG1739	Uncharacterized protein family UPF0029
GTF74_RS13640	COG0183	Belongs to the thiolase family
GTF74_RS13645	COG0583	DNA-binding transcription factor activity
GTF74_RS13650	COG2814	Major facilitator Superfamily
GTF74_RS13655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTF74_RS13660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GTF74_RS13665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GTF74_RS13670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GTF74_RS13675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GTF74_RS13680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTF74_RS13685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GTF74_RS13695	COG0356	it plays a direct role in the translocation of protons across the membrane
GTF74_RS13700	COG3312	ion transport
GTF74_RS13705	COG1475	DNA binding
GTF74_RS13710	COG1192	Involved in chromosome partitioning
GTF74_RS13720	COG0445	tRNA wobble uridine modification
GTF74_RS13725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTF74_RS13730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GTF74_RS13735	COG0706	membrane insertase activity
GTF74_RS13745	COG0594	ribonuclease P activity
GTF74_RS13750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GTF74_RS13755	COG1126	abc transporter atp-binding protein
GTF74_RS13800	COG0217	transcriptional regulatory protein
GTF74_RS13805	COG2084	Dehydrogenase
GTF74_RS13820	COG2909	trisaccharide binding
GTF74_RS13825	COG0058	SHG alpha-glucan phosphorylase activity
GTF74_RS13830	COG1640	4-alpha-glucanotransferase
GTF74_RS13835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GTF74_RS13845	COG3501	Rhs element vgr protein
GTF74_RS13880	COG0471	metal ion transport
GTF74_RS13885	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GTF74_RS13925	COG0671	phosphoesterase, PA-phosphatase related
GTF74_RS13930	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GTF74_RS13940	COG1999	signal sequence binding
GTF74_RS13955	COG0786	glutamate:sodium symporter activity
GTF74_RS13975	COG1566	PFAM secretion protein HlyD family protein
GTF74_RS13985	COG3706	GGDEF domain
GTF74_RS14000	COG0813	purine-nucleoside phosphorylase activity
GTF74_RS14005	COG3272	Protein of unknown function (DUF1722)
GTF74_RS14015	COG0415	Belongs to the DNA photolyase family
GTF74_RS14020	COG1388	LysM domain
GTF74_RS14020	COG1376	ErfK ybiS ycfS ynhG family protein
GTF74_RS14030	COG0513	Belongs to the DEAD box helicase family
GTF74_RS14035	COG1770	oligopeptidase
GTF74_RS14065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTF74_RS14070	COG0573	inorganic phosphate transmembrane transporter activity
GTF74_RS14075	COG0581	inorganic phosphate transmembrane transporter activity
GTF74_RS14080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTF74_RS14100	COG0659	secondary active sulfate transmembrane transporter activity
GTF74_RS14110	COG0739	heme binding
GTF74_RS14115	COG3300	MHYT domain
GTF74_RS14115	COG5001	Diguanylate cyclase
GTF74_RS14120	COG0583	DNA-binding transcription factor activity
GTF74_RS14125	COG2814	Major facilitator Superfamily
GTF74_RS14145	COG1301	dicarboxylic acid transport
GTF74_RS14155	COG1342	Belongs to the UPF0251 family
GTF74_RS14185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTF74_RS14190	COG0673	inositol 2-dehydrogenase activity
GTF74_RS14200	COG2771	luxR family
GTF74_RS14200	COG2200	EAL domain
GTF74_RS14205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTF74_RS14215	COG0564	pseudouridine synthase activity
GTF74_RS14305	COG3501	Rhs element vgr protein
GTF74_RS14325	COG1129	ABC transporter
GTF74_RS14330	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTF74_RS14335	COG1879	ABC-type sugar transport system periplasmic component
GTF74_RS14340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF74_RS14345	COG1609	Transcriptional regulator
GTF74_RS14355	COG3201	nicotinamide mononucleotide transporter
GTF74_RS14360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GTF74_RS14370	COG0584	glycerophosphoryl diester phosphodiesterase
GTF74_RS14375	COG2271	Major facilitator Superfamily
GTF74_RS14410	COG0579	oxidoreductase
GTF74_RS14420	COG0242	peptide deformylase activity
GTF74_RS14430	COG1320	monovalent cation:proton antiporter activity
GTF74_RS14435	COG2212	antiporter activity
GTF74_RS14455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTF74_RS14455	COG2111	Na H antiporter
GTF74_RS14465	COG0589	response to stress
GTF74_RS14470	COG0814	amino acid
GTF74_RS14485	COG3530	Putative quorum-sensing-regulated virulence factor
GTF74_RS14495	COG5002	protein histidine kinase activity
GTF74_RS14495	COG5001	Diguanylate cyclase
GTF74_RS14500	COG1278	Cold shock
GTF74_RS14515	COG2304	oxidoreductase activity
GTF74_RS14535	COG0714	Associated with various cellular activities
GTF74_RS14540	COG0840	transmembrane signaling receptor activity
GTF74_RS14555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTF74_RS14560	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTF74_RS14570	COG3604	Transcriptional regulator
GTF74_RS14575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTF74_RS14575	COG1017	nitric oxide dioxygenase activity
GTF74_RS14580	COG1278	Cold shock
GTF74_RS14585	COG3036	rescue of stalled ribosome
GTF74_RS14610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GTF74_RS14610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTF74_RS14615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTF74_RS14625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTF74_RS14635	COG0516	GMP reductase activity
GTF74_RS14670	COG0513	Belongs to the DEAD box helicase family
GTF74_RS14675	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GTF74_RS14680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GTF74_RS14685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GTF74_RS14690	COG0784	Response regulator, receiver
GTF74_RS14690	COG3437	response regulator, receiver
GTF74_RS14695	COG4191	Histidine kinase
GTF74_RS14695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF74_RS14705	COG1757	Na H antiporter
GTF74_RS14710	COG2814	Major facilitator Superfamily
GTF74_RS14720	COG3706	GGDEF domain
GTF74_RS14725	COG3240	lipase activity
GTF74_RS14735	COG0840	transmembrane signaling receptor activity
GTF74_RS14740	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GTF74_RS14745	COG5380	lipid catabolic process
GTF74_RS14770	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF74_RS14775	COG4605	iron ion homeostasis
GTF74_RS14780	COG4604	ABC transporter, ATP-binding protein
GTF74_RS14785	COG2207	Transcriptional regulator
GTF74_RS14800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTF74_RS14820	COG0745	RESPONSE REGULATOR receiver
GTF74_RS14830	COG3623	hexulose-6-phosphate isomerase
GTF74_RS14835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GTF74_RS14840	COG0561	phosphatase activity
GTF74_RS14870	COG3038	cytochrome b561
GTF74_RS14875	COG0366	Alpha amylase catalytic
GTF74_RS14900	COG0745	RESPONSE REGULATOR receiver
GTF74_RS14905	COG5002	protein histidine kinase activity
GTF74_RS14930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GTF74_RS14945	COG2814	Major facilitator Superfamily
GTF74_RS14960	COG1686	Belongs to the peptidase S11 family
GTF74_RS14985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTF74_RS14985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTF74_RS14990	COG0509	glycine decarboxylation via glycine cleavage system
GTF74_RS14995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTF74_RS15005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GTF74_RS15015	COG3039	Transposase
GTF74_RS15050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GTF74_RS15055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GTF74_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
GTF74_RS15145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GTF74_RS15170	COG0494	nUDIX hydrolase
GTF74_RS15190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF74_RS15195	COG3040	lipid binding
GTF74_RS15225	COG3041	Addiction module toxin RelE StbE family
GTF74_RS15320	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTF74_RS15375	COG0346	lactoylglutathione lyase activity
GTF74_RS15395	COG3040	lipid binding
GTF74_RS15410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GTF74_RS15420	COG1280	lysine exporter protein (LysE YggA)
GTF74_RS15605	COG3549	Plasmid maintenance system killer
GTF74_RS15610	COG3093	addiction module antidote protein HigA
GTF74_RS15630	COG0384	phenazine biosynthesis protein PhzF
GTF74_RS15660	COG0346	lactoylglutathione lyase activity
GTF74_RS15680	COG3040	lipid binding
GTF74_RS15735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF74_RS15835	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTF74_RS15860	COG3040	lipid binding
GTF74_RS15915	COG4977	sequence-specific DNA binding
GTF74_RS16005	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GTF74_RS16010	COG2944	sequence-specific DNA binding
GTF74_RS16025	COG3039	Transposase
GTF74_RS16050	COG0346	lactoylglutathione lyase activity
GTF74_RS16200	COG0346	lactoylglutathione lyase activity
GTF74_RS16220	COG1328	CTP reductase activity
GTF74_RS16225	COG0602	queuosine metabolic process
GTF74_RS16235	COG4067	protein conserved in archaea
GTF74_RS16235	COG0189	ligase activity
GTF74_RS16240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF74_RS16240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTF74_RS16240	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GTF74_RS16245	COG1105	Belongs to the carbohydrate kinase PfkB family
GTF74_RS16250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF74_RS16250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF74_RS16255	COG1609	Transcriptional regulator
GTF74_RS16260	COG0420	3'-5' exonuclease activity
GTF74_RS16265	COG0419	ATPase involved in DNA repair
GTF74_RS16270	COG0784	Response regulator, receiver
GTF74_RS16270	COG2205	protein histidine kinase activity
GTF74_RS16275	COG0156	8-amino-7-oxononanoate synthase activity
GTF74_RS16290	COG0523	cobalamin synthesis protein
GTF74_RS16305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GTF74_RS16305	COG1013	pyruvate-flavodoxin oxidoreductase activity
GTF74_RS16305	COG0674	pyruvate-flavodoxin oxidoreductase activity
GTF74_RS16305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GTF74_RS16310	COG2205	protein histidine kinase activity
GTF74_RS16315	COG0745	RESPONSE REGULATOR receiver
GTF74_RS16320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTF74_RS16325	COG0586	Pfam SNARE associated Golgi protein
GTF74_RS16335	COG2200	EAL domain
GTF74_RS16345	COG3038	cytochrome b561
GTF74_RS16355	COG2116	formate transmembrane transporter activity
GTF74_RS16360	COG0583	DNA-binding transcription factor activity
GTF74_RS16370	COG3593	DNA synthesis involved in DNA repair
GTF74_RS16375	COG0737	Belongs to the 5'-nucleotidase family
GTF74_RS16390	COG2824	Alkylphosphonate utilization operon protein PhnA
GTF74_RS16440	COG3706	GGDEF domain
GTF74_RS16455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GTF74_RS16460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GTF74_RS16470	COG0745	RESPONSE REGULATOR receiver
GTF74_RS16485	COG3140	Belongs to the UPF0181 family
GTF74_RS16490	COG0023	Translation Initiation Factor
GTF74_RS16510	COG0045	succinate-CoA ligase (ADP-forming) activity
GTF74_RS16510	COG1042	CoA-binding domain protein
GTF74_RS16510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF74_RS16515	COG0583	DNA-binding transcription factor activity
GTF74_RS16520	COG1629	transport
GTF74_RS16520	COG4771	TonB-dependent receptor
GTF74_RS16535	COG2050	protein possibly involved in aromatic compounds catabolism
GTF74_RS16555	COG0625	glutathione transferase activity
GTF74_RS16570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTF74_RS16575	COG4172	Belongs to the ABC transporter superfamily
GTF74_RS16580	COG4239	(ABC) transporter, permease
GTF74_RS16585	COG4174	ABC transporter (Permease)
GTF74_RS16590	COG4166	transmembrane transport
GTF74_RS16615	COG3104	oligopeptide transport
GTF74_RS16635	COG3842	ATPase activity
GTF74_RS16645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTF74_RS16655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTF74_RS16660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTF74_RS16665	COG1011	Hydrolase
GTF74_RS16675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GTF74_RS16680	COG1970	mechanosensitive ion channel activity
GTF74_RS16685	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GTF74_RS16690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF74_RS16690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTF74_RS16695	COG0302	gtp cyclohydrolase
GTF74_RS16705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTF74_RS16715	COG2897	thiosulfate sulfurtransferase activity
GTF74_RS16720	COG2390	Transcriptional regulator
GTF74_RS16730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTF74_RS16755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTF74_RS16780	COG0583	DNA-binding transcription factor activity
GTF74_RS16785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GTF74_RS16825	COG0446	pyridine nucleotide-disulphide oxidoreductase
GTF74_RS16870	COG1263	PTS System
GTF74_RS16870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTF74_RS16880	COG1621	beta-fructofuranosidase activity
GTF74_RS16885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF74_RS16890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTF74_RS16900	COG2885	chlorophyll binding
GTF74_RS16905	COG0545	Peptidyl-prolyl cis-trans isomerase
GTF74_RS16910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTF74_RS16915	COG0840	transmembrane signaling receptor activity
GTF74_RS16920	COG3069	C4-dicarboxylate transmembrane transporter activity
GTF74_RS16925	COG1760	l-serine dehydratase
GTF74_RS16945	COG1609	Transcriptional regulator
GTF74_RS16950	COG2197	response regulator
GTF74_RS16955	COG3850	Histidine kinase
GTF74_RS16960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GTF74_RS16970	COG0243	molybdopterin cofactor binding
GTF74_RS16990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTF74_RS16995	COG2197	response regulator
GTF74_RS17000	COG3851	Histidine kinase
GTF74_RS17005	COG2271	Major facilitator Superfamily
GTF74_RS17010	COG1840	ABC-type Fe3 transport system, periplasmic component
GTF74_RS17020	COG3842	ATPase activity
GTF74_RS17025	COG3243	poly(R)-hydroxyalkanoic acid synthase
GTF74_RS17035	COG0183	Belongs to the thiolase family
GTF74_RS17045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF74_RS17050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTF74_RS17065	COG3706	GGDEF domain
GTF74_RS17070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTF74_RS17080	COG1979	alcohol dehydrogenase
GTF74_RS17095	COG4191	Histidine kinase
GTF74_RS17105	COG2271	Major facilitator Superfamily
GTF74_RS17110	COG0469	pyruvate kinase activity
GTF74_RS17115	COG2205	protein histidine kinase activity
GTF74_RS17115	COG0784	Response regulator, receiver
GTF74_RS17115	COG2198	Histidine kinase
GTF74_RS17120	COG1879	ABC-type sugar transport system periplasmic component
GTF74_RS17125	COG1803	Methylglyoxal synthase
GTF74_RS17130	COG1335	isochorismatase
GTF74_RS17135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GTF74_RS17150	COG0210	DNA helicase
GTF74_RS17155	COG1289	transmembrane transporter activity
GTF74_RS17185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GTF74_RS17190	COG4149	molybdate abc transporter
GTF74_RS17195	COG0725	ABC transporter, periplasmic molybdate-binding protein
GTF74_RS17200	COG1492	cobalamin metabolic process
GTF74_RS17240	COG5002	protein histidine kinase activity
GTF74_RS17240	COG0784	Response regulator, receiver
GTF74_RS17245	COG1879	ABC-type sugar transport system periplasmic component
GTF74_RS17255	COG2827	Endonuclease containing a URI domain
GTF74_RS17270	COG2926	Belongs to the UPF0265 family
GTF74_RS17280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GTF74_RS17285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTF74_RS17290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTF74_RS17295	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GTF74_RS17300	COG0247	lactate metabolic process
GTF74_RS17305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTF74_RS17310	COG3118	belongs to the thioredoxin family
GTF74_RS17340	COG0583	DNA-binding transcription factor activity
GTF74_RS17345	COG4160	amino acid transport
GTF74_RS17350	COG4215	(ABC) transporter
GTF74_RS17355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF74_RS17360	COG1126	abc transporter atp-binding protein
GTF74_RS17370	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GTF74_RS17380	COG0494	nUDIX hydrolase
GTF74_RS17385	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GTF74_RS17395	COG1309	transcriptional regulator
GTF74_RS17400	COG0513	Belongs to the DEAD box helicase family
GTF74_RS17405	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GTF74_RS17410	COG0814	amino acid
GTF74_RS17415	COG0840	transmembrane signaling receptor activity
GTF74_RS17420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTF74_RS17425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GTF74_RS17435	COG1984	allophanate hydrolase subunit 2
GTF74_RS17450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GTF74_RS17455	COG4181	ATPase activity
GTF74_RS17465	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTF74_RS17470	COG5001	Diguanylate cyclase
GTF74_RS17470	COG1716	ATPase activity
GTF74_RS17480	COG0484	heat shock protein binding
GTF74_RS17520	COG0546	phosphoglycolate phosphatase activity
GTF74_RS17535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTF74_RS17540	COG1368	sulfuric ester hydrolase activity
GTF74_RS17550	COG0513	Belongs to the DEAD box helicase family
GTF74_RS17565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTF74_RS17575	COG3046	protein related to deoxyribodipyrimidine photolyase
GTF74_RS17580	COG3397	chitin binding
GTF74_RS17585	COG3227	Zinc metalloprotease (Elastase)
GTF74_RS17595	COG0010	Belongs to the arginase family
GTF74_RS17600	COG1166	arginine decarboxylase activity
GTF74_RS17610	COG2239	Acts as a magnesium transporter
GTF74_RS17615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTF74_RS17620	COG0459	protein refolding
GTF74_RS17630	COG0527	aspartate kinase activity
GTF74_RS17635	COG0662	Cupin 2, conserved barrel domain protein
GTF74_RS17640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTF74_RS17645	COG0456	acetyltransferase
GTF74_RS17655	COG3186	Phenylalanine-4-hydroxylase
GTF74_RS17660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTF74_RS17675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTF74_RS17700	COG1253	flavin adenine dinucleotide binding
GTF74_RS17705	COG1765	OsmC-like protein
GTF74_RS17730	COG0531	amino acid
GTF74_RS17735	COG3706	GGDEF domain
GTF74_RS17745	COG3279	Response regulator of the LytR AlgR family
GTF74_RS17750	COG3275	phosphorelay sensor kinase activity
GTF74_RS17765	COG0577	efflux transmembrane transporter activity
GTF74_RS17765	COG1136	(ABC) transporter
GTF74_RS17770	COG1136	(ABC) transporter
GTF74_RS17780	COG4989	oxidoreductase activity
GTF74_RS17785	COG0366	Alpha amylase catalytic
GTF74_RS17795	COG2067	long-chain fatty acid transport protein
GTF74_RS17800	COG2267	carboxylic ester hydrolase activity
GTF74_RS17810	COG3227	Zinc metalloprotease (Elastase)
GTF74_RS17820	COG3047	cAMP biosynthetic process
GTF74_RS17830	COG1686	Belongs to the peptidase S11 family
GTF74_RS17835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTF74_RS17840	COG1271	oxidase subunit
GTF74_RS17845	COG1294	oxidase, subunit
GTF74_RS17860	COG3048	D-serine ammonia-lyase activity
GTF74_RS17865	COG0583	DNA-binding transcription factor activity
GTF74_RS17910	COG1063	alcohol dehydrogenase
GTF74_RS17935	COG0346	lactoylglutathione lyase activity
GTF74_RS17955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GTF74_RS17960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTF74_RS17965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GTF74_RS17970	COG0363	glucosamine-6-phosphate deaminase activity
GTF74_RS17975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTF74_RS18000	COG1929	Belongs to the glycerate kinase type-1 family
GTF74_RS18005	COG2610	gluconate transmembrane transporter activity
GTF74_RS18010	COG3835	regulator
GTF74_RS18020	COG0748	coenzyme F420 binding
GTF74_RS18025	COG3721	Heme iron utilization protein
GTF74_RS18035	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GTF74_RS18040	COG0811	peptide transport
GTF74_RS18045	COG0848	biopolymer transport protein
GTF74_RS18050	COG4558	Periplasmic binding protein
GTF74_RS18055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTF74_RS18060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GTF74_RS18095	COG3217	Mosc domain protein beta barrel domain protein
GTF74_RS18095	COG3217	Mosc domain protein beta barrel domain protein
GTF74_RS18095	COG0633	Ferredoxin
GTF74_RS18095	COG0633	Ferredoxin
GTF74_RS18100	COG0418	dihydroorotase activity
GTF74_RS18110	COG3152	Membrane
GTF74_RS18120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTF74_RS18125	COG2354	Protein conserved in bacteria
GTF74_RS18130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GTF74_RS18135	COG1278	Cold shock
GTF74_RS18160	COG3706	GGDEF domain
GTF74_RS18165	COG1349	DNA-binding transcription factor activity
GTF74_RS18180	COG3833	ABC-type maltose transport systems, permease component
GTF74_RS18185	COG1175	transmembrane transport
GTF74_RS18195	COG3842	ATPase activity
GTF74_RS18200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTF74_RS18215	COG0393	Putative heavy-metal-binding
GTF74_RS18225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTF74_RS18230	COG0784	Response regulator, receiver
GTF74_RS18230	COG0835	chemotaxis
GTF74_RS18235	COG1846	Transcriptional regulator
GTF74_RS18240	COG3706	GGDEF domain
GTF74_RS18275	COG0583	DNA-binding transcription factor activity
GTF74_RS18280	COG5001	Diguanylate cyclase
GTF74_RS18290	COG1741	Belongs to the pirin family
GTF74_RS18295	COG3123	guanosine phosphorylase activity
GTF74_RS18305	COG2211	Major facilitator Superfamily
GTF74_RS18310	COG0840	transmembrane signaling receptor activity
GTF74_RS18315	COG1067	ATP-dependent peptidase activity
GTF74_RS18325	COG4172	Belongs to the ABC transporter superfamily
GTF74_RS18350	COG0583	DNA-binding transcription factor activity
GTF74_RS18360	COG1620	l-lactate permease
GTF74_RS18375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GTF74_RS18385	COG0840	transmembrane signaling receptor activity
GTF74_RS18395	COG0513	Belongs to the DEAD box helicase family
GTF74_RS18400	COG0583	DNA-binding transcription factor activity
GTF74_RS18410	COG1902	pentaerythritol trinitrate reductase activity
GTF74_RS18420	COG1132	(ABC) transporter
GTF74_RS18430	COG1902	pentaerythritol trinitrate reductase activity
GTF74_RS18440	COG1280	lysine exporter protein (LysE YggA)
GTF74_RS18445	COG2207	Transcriptional regulator
GTF74_RS18465	COG1846	Transcriptional regulator
GTF74_RS18470	COG1764	response to oxidative stress
GTF74_RS18475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GTF74_RS18480	COG0697	spore germination
GTF74_RS18490	COG0700	Nucleoside recognition
GTF74_RS18495	COG3366	ferrous iron transmembrane transporter activity
GTF74_RS18500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTF74_RS18510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTF74_RS18515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GTF74_RS18520	COG2259	Doxx family
GTF74_RS18545	COG0363	glucosamine-6-phosphate deaminase activity
GTF74_RS18560	COG4580	involved in the transport of maltose and maltodextrins
GTF74_RS18575	COG0840	transmembrane signaling receptor activity
GTF74_RS18590	COG0840	transmembrane signaling receptor activity
GTF74_RS18600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GTF74_RS18605	COG1126	abc transporter atp-binding protein
GTF74_RS18615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTF74_RS18620	COG4597	amino acid ABC transporter
GTF74_RS18625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTF74_RS18635	COG0739	heme binding
GTF74_RS18640	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTF74_RS18640	COG2213	PTS system mannitol-specific
GTF74_RS18645	COG0246	Mannitol dehydrogenase
GTF74_RS18650	COG3722	fumarate hydratase activity
GTF74_RS18655	COG0673	inositol 2-dehydrogenase activity
GTF74_RS18685	COG2910	NAD(P)H-binding
GTF74_RS18695	COG0840	transmembrane signaling receptor activity
GTF74_RS18700	COG4221	oxidoreductase activity
GTF74_RS18710	COG1901	pseudouridine methyltransferase
GTF74_RS18725	COG0531	amino acid
GTF74_RS18730	COG1982	Orn Lys Arg decarboxylase major
GTF74_RS18760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTF74_RS18785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GTF74_RS18825	COG0745	RESPONSE REGULATOR receiver
GTF74_RS18850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTF74_RS18855	COG0840	transmembrane signaling receptor activity
GTF74_RS18860	COG0835	chemotaxis
GTF74_RS18865	COG0835	chemotaxis
GTF74_RS18870	COG0643	Histidine kinase
GTF74_RS18870	COG2198	Histidine kinase
GTF74_RS18890	COG0601	transmembrane transport
GTF74_RS18895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTF74_RS18905	COG2194	sulfuric ester hydrolase activity
GTF74_RS18910	COG0642	Histidine kinase
GTF74_RS18915	COG0745	RESPONSE REGULATOR receiver
GTF74_RS18945	COG1444	tRNA N-acetyltransferase activity
GTF74_RS18950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine