locus-tag	class	description
IR04_RS00010	COG0706	membrane insertase activity
IR04_RS00040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IR04_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR04_RS00200	COG0408	coproporphyrinogen oxidase activity
IR04_RS00300	COG1528	Iron-storage protein
IR04_RS00315	COG1322	Protein conserved in bacteria
IR04_RS00520	COG3287	FIST C domain
IR04_RS00520	COG2199	diguanylate cyclase activity
IR04_RS00520	COG2200	EAL domain
IR04_RS00575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR04_RS00605	COG4206	TonB-dependent receptor
IR04_RS00660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IR04_RS00875	COG4774	siderophore transport
IR04_RS01205	COG0138	bifunctional purine biosynthesis protein purh
IR04_RS01215	COG3710	Transcriptional regulator
IR04_RS01330	COG2814	Major facilitator Superfamily
IR04_RS01420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IR04_RS01555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IR04_RS01620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IR04_RS01640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IR04_RS01670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IR04_RS01785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IR04_RS01800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IR04_RS01810	COG0330	HflC and HflK could
IR04_RS01925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IR04_RS01950	COG0166	Belongs to the GPI family
IR04_RS01980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR04_RS02125	COG0646	methionine synthase
IR04_RS02125	COG1410	methionine synthase
IR04_RS02325	COG0142	geranyltranstransferase activity
IR04_RS02410	COG1194	a g-specific adenine glycosylase
IR04_RS02690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR04_RS02735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IR04_RS03260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IR04_RS04145	COG0581	inorganic phosphate transmembrane transporter activity
IR04_RS04235	COG0483	inositol monophosphate 1-phosphatase activity
IR04_RS04285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IR04_RS04330	COG1570	exodeoxyribonuclease VII activity
IR04_RS04955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IR04_RS04960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IR04_RS04965	COG0706	membrane insertase activity
IR04_RS04975	COG0594	ribonuclease P activity
IR04_RS04980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IR04_RS04985	COG1126	abc transporter atp-binding protein
IR04_RS05000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IR04_RS05005	COG0592	DNA-directed DNA polymerase activity
IR04_RS05010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IR04_RS05015	COG0187	DNA topoisomerase II activity
IR04_RS05030	COG0071	Belongs to the small heat shock protein (HSP20) family
IR04_RS05035	COG3977	Valine--pyruvate aminotransferase
IR04_RS05040	COG0751	glycine-tRNA ligase activity
IR04_RS05045	COG0752	glycyl-tRNA synthetase alpha subunit
IR04_RS05050	COG2119	membrane
IR04_RS05060	COG0425	Belongs to the sulfur carrier protein TusA family
IR04_RS05070	COG0604	alcohol dehydrogenase
IR04_RS05080	COG0129	dihydroxy-acid dehydratase activity
IR04_RS05085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IR04_RS05100	COG0606	chelatase, subunit chli
IR04_RS05105	COG0204	Acyl-transferase
IR04_RS05110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IR04_RS05125	COG3084	Protein conserved in bacteria
IR04_RS05135	COG4326	sporulation control protein
IR04_RS05140	COG1272	protein, Hemolysin III
IR04_RS05150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR04_RS05155	COG0569	domain protein
IR04_RS05160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR04_RS05160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR04_RS05165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IR04_RS05170	COG0242	peptide deformylase activity
IR04_RS05175	COG1652	LysM domain
IR04_RS05180	COG0758	DNA mediated transformation
IR04_RS05185	COG2922	Belongs to the Smg family
IR04_RS05190	COG0551	DNA topoisomerase type I activity
IR04_RS05195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IR04_RS05200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IR04_RS05205	COG0009	L-threonylcarbamoyladenylate synthase
IR04_RS05210	COG0408	coproporphyrinogen oxidase activity
IR04_RS05215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IR04_RS05225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IR04_RS05270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IR04_RS05275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IR04_RS05285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IR04_RS05290	COG2104	thiamine diphosphate biosynthetic process
IR04_RS05295	COG2022	thiamine diphosphate biosynthetic process
IR04_RS05300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IR04_RS05305	COG0006	proline dipeptidase activity
IR04_RS05305	COG0006	proline dipeptidase activity
IR04_RS05325	COG1522	sequence-specific DNA binding
IR04_RS05330	COG5001	Diguanylate cyclase
IR04_RS05330	COG5002	protein histidine kinase activity
IR04_RS05350	COG0589	response to stress
IR04_RS05360	COG1528	Iron-storage protein
IR04_RS05370	COG2081	HI0933 family
IR04_RS05380	COG1322	Protein conserved in bacteria
IR04_RS05385	COG2226	methyltransferase
IR04_RS05400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR04_RS05405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR04_RS05410	COG0805	protein transport
IR04_RS05415	COG1858	cytochrome C peroxidase
IR04_RS05420	COG0534	Mate efflux family protein
IR04_RS05430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IR04_RS05440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IR04_RS05445	COG3161	chorismate lyase activity
IR04_RS05455	COG1580	Controls the rotational direction of flagella during chemotaxis
IR04_RS05460	COG0840	transmembrane signaling receptor activity
IR04_RS05470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR04_RS05480	COG0084	hydrolase, TatD family'
IR04_RS05495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR04_RS05495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR04_RS05515	COG3078	GTPase activator activity
IR04_RS05530	COG3071	HemY protein
IR04_RS05535	COG2959	enzyme of heme biosynthesis
IR04_RS05540	COG1587	Uroporphyrinogen-III synthase
IR04_RS05545	COG0181	hydroxymethylbilane synthase activity
IR04_RS05560	COG1965	Belongs to the frataxin family
IR04_RS05570	COG0019	diaminopimelate decarboxylase activity
IR04_RS05575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IR04_RS05585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IR04_RS05590	COG1011	Hydrolase
IR04_RS05595	COG2199	diguanylate cyclase activity
IR04_RS05595	COG2200	EAL domain
IR04_RS05595	COG3287	FIST C domain
IR04_RS05615	COG0561	phosphatase activity
IR04_RS05620	COG2267	carboxylic ester hydrolase activity
IR04_RS05625	COG1280	lysine exporter protein (LysE YggA)
IR04_RS05630	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IR04_RS05635	COG0783	Belongs to the Dps family
IR04_RS05670	COG0742	ribosomal rna small subunit methyltransferase
IR04_RS05675	COG0552	protein localization to endoplasmic reticulum
IR04_RS05680	COG2884	Cell division ATP-binding protein ftsE
IR04_RS05685	COG2177	Part of the ABC transporter FtsEX involved in
IR04_RS05690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IR04_RS05695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR04_RS05710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IR04_RS05715	COG4206	TonB-dependent receptor
IR04_RS05720	COG1404	Belongs to the peptidase S8 family
IR04_RS05725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IR04_RS05760	COG0583	DNA-binding transcription factor activity
IR04_RS05765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IR04_RS05770	COG2960	long-chain fatty acid transporting porin activity
IR04_RS05775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR04_RS05780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR04_RS05785	COG1309	transcriptional regulator
IR04_RS05840	COG0747	negative chemotaxis
IR04_RS05845	COG0601	transmembrane transport
IR04_RS05850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR04_RS05860	COG2131	deaminase
IR04_RS05885	COG3621	Patatin-like phospholipase
IR04_RS05930	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IR04_RS05940	COG0210	DNA helicase
IR04_RS05945	COG1280	lysine exporter protein (LysE YggA)
IR04_RS05960	COG2962	Rard protein
IR04_RS05965	COG0514	ATP-dependent DNA helicase (RecQ)
IR04_RS05980	COG1132	(ABC) transporter
IR04_RS05985	COG4774	siderophore transport
IR04_RS05990	COG1120	ATPase activity
IR04_RS06015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR04_RS06020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR04_RS06020	COG1263	PTS System
IR04_RS06025	COG2862	Uncharacterized protein family, UPF0114
IR04_RS06030	COG1561	YicC-like family, N-terminal region
IR04_RS06040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IR04_RS06045	COG1560	Kdo2-lipid A biosynthetic process
IR04_RS06050	COG1560	Kdo2-lipid A biosynthetic process
IR04_RS06055	COG1309	transcriptional regulator
IR04_RS06060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IR04_RS06070	COG2003	Belongs to the UPF0758 family
IR04_RS06075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IR04_RS06080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IR04_RS06090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IR04_RS06095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IR04_RS06100	COG0859	PFAM glycosyl transferase family 9
IR04_RS06105	COG0463	Glycosyl transferase, family 2
IR04_RS06110	COG0859	PFAM glycosyl transferase family 9
IR04_RS06115	COG3642	lipopolysaccharide core region biosynthetic process
IR04_RS06145	COG1519	Transferase
IR04_RS06180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR04_RS06185	COG0662	Cupin 2, conserved barrel domain protein
IR04_RS06185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IR04_RS06190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR04_RS06195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IR04_RS06225	COG0318	PFAM AMP-dependent synthetase and ligase
IR04_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
IR04_RS06230	COG1454	alcohol dehydrogenase
IR04_RS06245	COG5433	transposase activity
IR04_RS06275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IR04_RS06280	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IR04_RS06285	COG0668	transmembrane transport
IR04_RS06290	COG1573	uracil-dna glycosylase
IR04_RS06300	COG3068	Protein conserved in bacteria
IR04_RS06310	COG1940	carbohydrate kinase activity
IR04_RS06315	COG1253	flavin adenine dinucleotide binding
IR04_RS06325	COG0776	regulation of translation
IR04_RS06335	COG0151	Belongs to the GarS family
IR04_RS06350	COG0789	Transcriptional regulator
IR04_RS06355	COG3710	Transcriptional regulator
IR04_RS06360	COG0531	amino acid
IR04_RS06365	COG1982	Orn Lys Arg decarboxylase major
IR04_RS06370	COG0840	transmembrane signaling receptor activity
IR04_RS06390	COG0800	Aldolase
IR04_RS06400	COG3265	gluconokinase activity
IR04_RS06405	COG0129	dihydroxy-acid dehydratase activity
IR04_RS06410	COG1609	Transcriptional regulator
IR04_RS06415	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IR04_RS06420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR04_RS06425	COG2264	protein methyltransferase activity
IR04_RS06430	COG0439	Biotin carboxylase
IR04_RS06435	COG0511	ligase activity, forming carbon-carbon bonds
IR04_RS06440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IR04_RS06445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR04_RS06465	COG2814	Major facilitator Superfamily
IR04_RS06470	COG2205	protein histidine kinase activity
IR04_RS06470	COG0784	Response regulator, receiver
IR04_RS06475	COG0248	Ppx GppA phosphatase
IR04_RS06480	COG0513	Belongs to the DEAD box helicase family
IR04_RS06485	COG3118	belongs to the thioredoxin family
IR04_RS06500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IR04_RS06545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IR04_RS06560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IR04_RS06570	COG1072	(Pantothenic acid kinase))
IR04_RS06595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IR04_RS06600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR04_RS06605	COG0250	Participates in transcription elongation, termination and antitermination
IR04_RS06610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IR04_RS06620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IR04_RS06625	COG0222	ribosome binding
IR04_RS06630	COG0085	RNA polymerase activity
IR04_RS06635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IR04_RS06640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IR04_RS06645	COG2816	NAD+ diphosphatase activity
IR04_RS06650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IR04_RS06665	COG4942	peptidase
IR04_RS06670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IR04_RS06680	COG0471	metal ion transport
IR04_RS06685	COG0688	phosphatidylethanolamine metabolic process
IR04_RS06690	COG1162	GTPase activity
IR04_RS06695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IR04_RS06740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IR04_RS06745	COG0802	atpase or kinase
IR04_RS06755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IR04_RS06760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IR04_RS06765	COG1923	regulation of RNA biosynthetic process
IR04_RS06770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IR04_RS06775	COG0330	HflC and HflK could
IR04_RS06780	COG0330	HflC and HflK could
IR04_RS06785	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IR04_RS06790	COG2900	Belongs to the SlyX family
IR04_RS06800	COG0545	Peptidyl-prolyl cis-trans isomerase
IR04_RS06805	COG2964	Protein conserved in bacteria
IR04_RS06810	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IR04_RS06815	COG2923	Belongs to the DsrF TusC family
IR04_RS06830	COG0049	tRNA binding
IR04_RS06835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IR04_RS06840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IR04_RS06845	COG2906	2 iron, 2 sulfur cluster binding
IR04_RS06855	COG0360	Binds together with S18 to 16S ribosomal RNA
IR04_RS06860	COG2965	DNA replication, synthesis of RNA primer
IR04_RS06865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IR04_RS06870	COG0359	binds to the 23S rRNA
IR04_RS06885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IR04_RS06890	COG0432	Pfam Uncharacterised protein family UPF0047
IR04_RS06910	COG0735	belongs to the Fur family
IR04_RS06915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR04_RS06940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IR04_RS06950	COG0175	sulfate reduction
IR04_RS06990	COG1410	methionine synthase
IR04_RS06990	COG0646	methionine synthase
IR04_RS06995	COG0527	aspartate kinase activity
IR04_RS07000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IR04_RS07010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IR04_RS07025	COG0629	single-stranded DNA binding
IR04_RS07030	COG2199	diguanylate cyclase activity
IR04_RS07030	COG2200	EAL domain
IR04_RS07055	COG3267	Type II secretory pathway component ExeA
IR04_RS07055	COG3409	Peptidoglycan-binding domain 1 protein
IR04_RS07065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR04_RS07070	COG1459	type II secretion system
IR04_RS07080	COG2165	general secretion pathway protein
IR04_RS07085	COG2165	general secretion pathway protein
IR04_RS07115	COG1077	Cell shape determining protein MreB Mrl
IR04_RS07120	COG1792	Involved in formation and maintenance of cell shape
IR04_RS07125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IR04_RS07130	COG0424	maF-like protein
IR04_RS07140	COG3164	Protein of unknown function
IR04_RS07145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IR04_RS07150	COG0312	modulator of DNA gyrase
IR04_RS07155	COG2235	arginine
IR04_RS07175	COG0589	response to stress
IR04_RS07185	COG2358	TRAP transporter, solute receptor (TAXI family
IR04_RS07190	COG1438	arginine binding
IR04_RS07195	COG0039	L-malate dehydrogenase activity
IR04_RS07200	COG0531	amino acid
IR04_RS07205	COG0531	amino acid
IR04_RS07210	COG0142	geranyltranstransferase activity
IR04_RS07215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IR04_RS07220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IR04_RS07225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IR04_RS07230	COG2966	Psort location CytoplasmicMembrane, score
IR04_RS07235	COG3610	response to peptide
IR04_RS07245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IR04_RS07250	COG2967	ApaG domain
IR04_RS07255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IR04_RS07260	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IR04_RS07265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR04_RS07270	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IR04_RS07275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IR04_RS07330	COG0741	lytic transglycosylase activity
IR04_RS07335	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IR04_RS07340	COG1194	a g-specific adenine glycosylase
IR04_RS07350	COG2066	Belongs to the glutaminase family
IR04_RS07355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IR04_RS07360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IR04_RS07370	COG1872	DUF167
IR04_RS07375	COG0762	integral membrane protein
IR04_RS07380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IR04_RS07385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IR04_RS07405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IR04_RS07410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IR04_RS07415	COG1678	Uncharacterized ACR, COG1678
IR04_RS07420	COG0189	ligase activity
IR04_RS07425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IR04_RS07430	COG2356	endonuclease I
IR04_RS07440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IR04_RS07450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IR04_RS07455	COG0583	DNA-binding transcription factor activity
IR04_RS07460	COG4771	TonB-dependent receptor
IR04_RS07465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IR04_RS07470	COG0126	phosphoglycerate kinase activity
IR04_RS07475	COG0191	fructose-bisphosphate aldolase activity
IR04_RS07485	COG0668	transmembrane transport
IR04_RS07490	COG1279	arginine transmembrane transporter activity
IR04_RS07510	COG1349	DNA-binding transcription factor activity
IR04_RS07515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IR04_RS07520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IR04_RS07565	COG2207	Transcriptional regulator
IR04_RS07575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IR04_RS07580	COG0582	viral genome integration into host DNA
IR04_RS07595	COG0358	DNA primase activity
IR04_RS07600	COG1610	YqeY-like protein
IR04_RS07605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IR04_RS07610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IR04_RS07620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR04_RS07625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IR04_RS07630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR04_RS07635	COG1968	undecaprenyl-diphosphatase activity
IR04_RS07640	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IR04_RS07645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IR04_RS07650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IR04_RS07655	COG0585	pseudouridine synthase activity
IR04_RS07660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IR04_RS07665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IR04_RS07680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IR04_RS07700	COG4208	sulfate ABC transporter
IR04_RS07705	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IR04_RS07715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IR04_RS07725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IR04_RS07730	COG0527	aspartate kinase activity
IR04_RS07735	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IR04_RS07785	COG3630	sodium ion export across plasma membrane
IR04_RS07790	COG5016	pyruvate
IR04_RS07790	COG0511	ligase activity, forming carbon-carbon bonds
IR04_RS07795	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IR04_RS07805	COG1238	metal cluster binding
IR04_RS07810	COG0612	Peptidase, M16
IR04_RS07815	COG2918	glutathione biosynthetic process
IR04_RS07820	COG1854	S-ribosylhomocysteine lyase activity
IR04_RS07825	COG4536	flavin adenine dinucleotide binding
IR04_RS07830	COG4137	Cytochrome C assembly protein
IR04_RS07835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IR04_RS07840	COG0228	four-way junction DNA binding
IR04_RS07845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IR04_RS07850	COG0336	Belongs to the RNA methyltransferase TrmD family
IR04_RS07855	COG0335	large ribosomal subunit rRNA binding
IR04_RS07860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR04_RS07875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IR04_RS07885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IR04_RS07890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IR04_RS07895	COG0723	plastoquinol--plastocyanin reductase activity
IR04_RS07905	COG2857	Cytochrome c1
IR04_RS07910	COG0625	glutathione transferase activity
IR04_RS07915	COG2969	positive regulation of protein catabolic process
IR04_RS07920	COG2823	Periplasmic or secreted lipoprotein
IR04_RS07925	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IR04_RS07930	COG0792	nuclease activity
IR04_RS07935	COG3107	peptidoglycan biosynthetic process
IR04_RS07940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IR04_RS07955	COG0288	reversible hydration of carbon dioxide
IR04_RS07960	COG0659	secondary active sulfate transmembrane transporter activity
IR04_RS07965	COG1131	(ABC) transporter
IR04_RS07970	COG0842	Transport permease protein
IR04_RS07975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IR04_RS07980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IR04_RS07985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR04_RS07995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR04_RS08005	COG1489	DNA binding
IR04_RS08015	COG1643	Atp-dependent helicase
IR04_RS08020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR04_RS08025	COG1752	Esterase of the alpha-beta hydrolase superfamily
IR04_RS08030	COG1049	propionate catabolic process, 2-methylcitrate cycle
IR04_RS08035	COG3112	Uncharacterised protein family (UPF0231)
IR04_RS08040	COG0347	Belongs to the P(II) protein family
IR04_RS08045	COG0004	ammonium transporteR
IR04_RS08050	COG1840	ABC-type Fe3 transport system, periplasmic component
IR04_RS08060	COG3842	ATPase activity
IR04_RS08080	COG2971	BadF BadG BcrA BcrD
IR04_RS08090	COG4608	Belongs to the ABC transporter superfamily
IR04_RS08095	COG0444	Belongs to the ABC transporter superfamily
IR04_RS08100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR04_RS08105	COG0601	transmembrane transport
IR04_RS08110	COG0747	negative chemotaxis
IR04_RS08120	COG2205	protein histidine kinase activity
IR04_RS08120	COG0784	Response regulator, receiver
IR04_RS08125	COG2813	Specifically methylates the guanine in position
IR04_RS08130	COG0628	permease
IR04_RS08140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IR04_RS08145	COG0316	Belongs to the HesB IscA family
IR04_RS08160	COG0739	heme binding
IR04_RS08165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IR04_RS08170	COG2027	D-alanyl-D-alanine carboxypeptidase
IR04_RS08175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IR04_RS08180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR04_RS08185	COG1534	Rna-binding protein
IR04_RS08190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IR04_RS08195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IR04_RS08200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IR04_RS08210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR04_RS08225	COG0779	Required for maturation of 30S ribosomal subunits
IR04_RS08230	COG0195	Participates in both transcription termination and antitermination
IR04_RS08235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IR04_RS08240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IR04_RS08250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IR04_RS08275	COG0826	peptidase U32
IR04_RS08280	COG0826	peptidase U32
IR04_RS08290	COG3154	lipid carrier protein
IR04_RS08295	COG3153	acetyltransferase
IR04_RS08410	COG3328	transposase activity
IR04_RS08425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IR04_RS08560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IR04_RS08575	COG0681	Belongs to the peptidase S26 family
IR04_RS08615	COG2356	endonuclease I
IR04_RS08630	COG0629	single-stranded DNA binding
IR04_RS08645	COG0714	Associated with various cellular activities
IR04_RS08670	COG2003	Belongs to the UPF0758 family
IR04_RS08785	COG0513	Belongs to the DEAD box helicase family
IR04_RS08800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IR04_RS08805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IR04_RS08810	COG2204	response regulator
IR04_RS08820	COG0667	Aldo Keto reductase
IR04_RS08835	COG0494	nUDIX hydrolase
IR04_RS08840	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IR04_RS08845	COG0730	response to heat
IR04_RS08850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IR04_RS08865	COG0583	DNA-binding transcription factor activity
IR04_RS08870	COG0640	Transcriptional regulator
IR04_RS08875	COG0268	Binds directly to 16S ribosomal RNA
IR04_RS08880	COG0728	peptidoglycan biosynthetic process
IR04_RS08885	COG0196	riboflavin kinase activity
IR04_RS08900	COG1047	Peptidyl-prolyl cis-trans
IR04_RS08905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IR04_RS08910	COG1966	Carbon starvation protein
IR04_RS08925	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR04_RS08930	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IR04_RS08940	COG3279	Response regulator of the LytR AlgR family
IR04_RS08945	COG3275	phosphorelay sensor kinase activity
IR04_RS08950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IR04_RS08955	COG0287	Prephenate dehydrogenase
IR04_RS08955	COG1605	Chorismate mutase
IR04_RS08965	COG0488	(ABC) transporter
IR04_RS08975	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IR04_RS08985	COG5001	Diguanylate cyclase
IR04_RS08990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IR04_RS08995	COG0077	Prephenate dehydratase
IR04_RS08995	COG1605	Chorismate mutase
IR04_RS09000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IR04_RS09005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR04_RS09010	COG0564	pseudouridine synthase activity
IR04_RS09020	COG0542	response to heat
IR04_RS09060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IR04_RS09065	COG0826	peptidase U32
IR04_RS09075	COG0745	RESPONSE REGULATOR receiver
IR04_RS09080	COG5002	protein histidine kinase activity
IR04_RS09090	COG0248	Ppx GppA phosphatase
IR04_RS09095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IR04_RS09105	COG0581	inorganic phosphate transmembrane transporter activity
IR04_RS09110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IR04_RS09125	COG3142	Participates in the control of copper homeostasis
IR04_RS09130	COG0450	alkyl hydroperoxide reductase
IR04_RS09135	COG0583	DNA-binding transcription factor activity
IR04_RS09140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IR04_RS09150	COG0517	IMP dehydrogenase activity
IR04_RS09170	COG1862	Preprotein translocase
IR04_RS09175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR04_RS09180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR04_RS09185	COG0483	inositol monophosphate 1-phosphatase activity
IR04_RS09195	COG1959	2 iron, 2 sulfur cluster binding
IR04_RS09200	COG1104	cysteine desulfurase activity
IR04_RS09205	COG0822	iron-sulfur transferase activity
IR04_RS09215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IR04_RS09220	COG0443	Heat shock 70 kDa protein
IR04_RS09225	COG0633	Ferredoxin
IR04_RS09230	COG2975	iron-sulfur cluster assembly
IR04_RS09235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR04_RS09240	COG0105	UTP biosynthetic process
IR04_RS09245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IR04_RS09255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IR04_RS09260	COG0124	histidyl-tRNA synthetase
IR04_RS09265	COG2976	Protein conserved in bacteria
IR04_RS09270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR04_RS09275	COG1160	GTP binding
IR04_RS09290	COG1570	exodeoxyribonuclease VII activity
IR04_RS09295	COG0517	IMP dehydrogenase activity
IR04_RS09295	COG0516	GMP reductase activity
IR04_RS09300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IR04_RS09300	COG0519	Catalyzes the synthesis of GMP from XMP
IR04_RS09310	COG1584	GPR1 FUN34 yaaH family protein
IR04_RS09315	COG1535	isochorismatase
IR04_RS09315	COG3433	isochorismatase activity
IR04_RS09320	COG1021	2,3-dihydroxybenzoate-AMP ligase
IR04_RS09325	COG1169	isochorismate synthase
IR04_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
IR04_RS09340	COG4592	Periplasmic binding protein
IR04_RS09345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR04_RS09350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR04_RS09355	COG1120	ATPase activity
IR04_RS09365	COG0583	DNA-binding transcription factor activity
IR04_RS09370	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IR04_RS09375	COG1115	amino acid carrier protein
IR04_RS09385	COG0583	DNA-binding transcription factor activity
IR04_RS09400	COG4565	transcriptional regulatory protein
IR04_RS09410	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IR04_RS09415	COG5016	pyruvate
IR04_RS09415	COG0511	ligase activity, forming carbon-carbon bonds
IR04_RS09420	COG3630	sodium ion export across plasma membrane
IR04_RS09430	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
IR04_RS09440	COG2301	Belongs to the HpcH HpaI aldolase family
IR04_RS09445	COG3051	citrate lyase alpha subunit
IR04_RS09465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR04_RS09470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IR04_RS09475	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IR04_RS09545	COG1012	belongs to the aldehyde dehydrogenase family
IR04_RS09565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IR04_RS09570	COG0840	transmembrane signaling receptor activity
IR04_RS09575	COG3710	Transcriptional regulator
IR04_RS09585	COG2165	general secretion pathway protein
IR04_RS09600	COG4796	Type ii and iii secretion system protein
IR04_RS09620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR04_RS09625	COG1459	type II secretion system
IR04_RS09635	COG2207	Transcriptional regulator
IR04_RS09640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IR04_RS09660	COG0739	heme binding
IR04_RS09670	COG3064	Membrane
IR04_RS09680	COG0582	viral genome integration into host DNA
IR04_RS09685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IR04_RS09690	COG2867	negative regulation of translational initiation
IR04_RS09695	COG2914	Belongs to the UPF0125 (RnfH) family
IR04_RS09700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR04_RS09705	COG0497	DNA recombination
IR04_RS09710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IR04_RS09715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IR04_RS09720	COG0443	Heat shock 70 kDa protein
IR04_RS09725	COG0484	heat shock protein binding
IR04_RS09760	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IR04_RS09775	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IR04_RS09815	COG0442	prolyl-tRNA aminoacylation
IR04_RS09820	COG1720	tRNA m6t6A37 methyltransferase activity
IR04_RS09825	COG0254	rRNA binding
IR04_RS09830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IR04_RS09835	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IR04_RS09840	COG1671	Belongs to the UPF0178 family
IR04_RS09850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR04_RS09865	COG3098	single-species biofilm formation
IR04_RS09870	COG0564	pseudouridine synthase activity
IR04_RS09875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IR04_RS09880	COG0142	geranyltranstransferase activity
IR04_RS09885	COG1722	exodeoxyribonuclease VII activity
IR04_RS09890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IR04_RS09900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR04_RS09900	COG0301	tRNA thio-modification
IR04_RS09910	COG0583	DNA-binding transcription factor activity
IR04_RS09915	COG2363	Small membrane protein
IR04_RS09925	COG1611	Belongs to the LOG family
IR04_RS09940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IR04_RS09940	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IR04_RS09950	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IR04_RS09955	COG1464	Belongs to the NlpA lipoprotein family
IR04_RS09960	COG2011	ABC-type metal ion transport system permease component
IR04_RS09965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IR04_RS09970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IR04_RS09975	COG1609	Transcriptional regulator
IR04_RS09980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR04_RS09980	COG1263	PTS System
IR04_RS09985	COG0366	Alpha amylase catalytic
IR04_RS10015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IR04_RS10020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IR04_RS10025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IR04_RS10030	COG0110	maltose O-acetyltransferase activity
IR04_RS10050	COG1045	serine acetyltransferase
IR04_RS10060	COG0438	transferase activity, transferring glycosyl groups
IR04_RS10070	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IR04_RS10100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IR04_RS10110	COG1596	polysaccharide export
IR04_RS10135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IR04_RS10145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IR04_RS10150	COG0321	lipoyl(octanoyl) transferase activity
IR04_RS10155	COG2921	Belongs to the UPF0250 family
IR04_RS10165	COG1686	Belongs to the peptidase S11 family
IR04_RS10170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IR04_RS10175	COG0772	Belongs to the SEDS family
IR04_RS10180	COG0768	penicillin binding
IR04_RS10185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IR04_RS10190	COG0799	negative regulation of ribosome biogenesis
IR04_RS10195	COG1466	dna polymerase III delta subunit
IR04_RS10200	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IR04_RS10205	COG0495	leucyl-tRNA aminoacylation
IR04_RS10210	COG2888	peptidyl-tyrosine sulfation
IR04_RS10215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IR04_RS10220	COG4535	Mg2 and Co2 transporter CorC
IR04_RS10230	COG1702	phosphate starvation-inducible protein PhoH
IR04_RS10235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR04_RS10240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR04_RS10245	COG2190	(PTS) system
IR04_RS10255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR04_RS10265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IR04_RS10270	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IR04_RS10275	COG3115	cell septum assembly
IR04_RS10280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IR04_RS10295	COG0789	Transcriptional regulator
IR04_RS10300	COG1585	Membrane protein implicated in regulation of membrane protease activity
IR04_RS10305	COG0330	HflC and HflK could
IR04_RS10310	COG3118	belongs to the thioredoxin family
IR04_RS10315	COG0300	oxidoreductase activity
IR04_RS10320	COG1090	epimerase
IR04_RS10325	COG0622	Phosphoesterase
IR04_RS10340	COG3710	Transcriptional regulator
IR04_RS10345	COG0326	Molecular chaperone. Has ATPase activity
IR04_RS10350	COG0563	adenylate kinase activity
IR04_RS10355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IR04_RS10370	COG0367	asparagine synthase
IR04_RS10375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR04_RS10375	COG4651	solute:proton antiporter activity
IR04_RS10380	COG1940	carbohydrate kinase activity
IR04_RS10380	COG1846	Transcriptional regulator
IR04_RS10385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IR04_RS10390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR04_RS10390	COG1263	PTS System
IR04_RS10390	COG2190	(PTS) system
IR04_RS10405	COG0101	tRNA pseudouridine synthase activity
IR04_RS10410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IR04_RS10415	COG0285	dihydrofolate synthase activity
IR04_RS10420	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IR04_RS10425	COG1286	toxin biosynthetic process
IR04_RS10430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IR04_RS10435	COG2056	Na+-H+ antiporter family
IR04_RS10440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IR04_RS10460	COG0346	lactoylglutathione lyase activity
IR04_RS10465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IR04_RS10490	COG2878	Part of a membrane complex involved in electron transport
IR04_RS10495	COG4657	Part of a membrane complex involved in electron transport
IR04_RS10505	COG0556	nucleotide-excision repair
IR04_RS10515	COG2204	response regulator
IR04_RS10520	COG2198	Histidine kinase
IR04_RS10525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IR04_RS10530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IR04_RS10535	COG0521	Mo-molybdopterin cofactor biosynthetic process
IR04_RS10540	COG0315	cyclic pyranopterin monophosphate synthase activity
IR04_RS10545	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IR04_RS10550	COG0314	molybdopterin synthase activity
IR04_RS10555	COG2199	diguanylate cyclase activity
IR04_RS10560	COG0517	IMP dehydrogenase activity
IR04_RS10560	COG0617	tRNA 3'-terminal CCA addition
IR04_RS10560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IR04_RS10575	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IR04_RS10585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR04_RS10585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR04_RS10590	COG0489	protein tyrosine kinase activity
IR04_RS10600	COG0572	uridine kinase
IR04_RS10605	COG2982	Protein involved in outer membrane biogenesis
IR04_RS10610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IR04_RS10615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IR04_RS10625	COG2067	long-chain fatty acid transport protein
IR04_RS10645	COG0183	Belongs to the thiolase family
IR04_RS10650	COG1024	Enoyl-CoA hydratase
IR04_RS10650	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR04_RS10655	COG0778	Nitroreductase
IR04_RS10660	COG0583	DNA-binding transcription factor activity
IR04_RS10665	COG0745	RESPONSE REGULATOR receiver
IR04_RS10675	COG2832	Protein of unknown function (DUF454)
IR04_RS10680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IR04_RS10690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IR04_RS10695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IR04_RS10705	COG2983	Belongs to the UPF0260 family
IR04_RS10710	COG1028	Short-chain dehydrogenase reductase Sdr
IR04_RS10715	COG0616	signal peptide processing
IR04_RS10725	COG1522	sequence-specific DNA binding
IR04_RS10750	COG3706	GGDEF domain
IR04_RS10755	COG0640	Transcriptional regulator
IR04_RS10760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IR04_RS10785	COG1881	PFAM PEBP family protein
IR04_RS10805	COG0009	L-threonylcarbamoyladenylate synthase
IR04_RS10820	COG2201	protein-glutamate methylesterase activity
IR04_RS10830	COG5002	protein histidine kinase activity
IR04_RS10835	COG4191	Histidine kinase
IR04_RS10840	COG3300	MHYT domain
IR04_RS10840	COG5001	Diguanylate cyclase
IR04_RS10845	COG2204	response regulator
IR04_RS10865	COG0601	transmembrane transport
IR04_RS10870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR04_RS10875	COG0444	Belongs to the ABC transporter superfamily
IR04_RS10880	COG4608	Belongs to the ABC transporter superfamily
IR04_RS10885	COG0435	Glutathione S-transferase
IR04_RS10890	COG0857	belongs to the CobB CobQ family
IR04_RS10890	COG0280	phosphate acetyltransferase
IR04_RS10895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IR04_RS10900	COG3092	negative regulation of chromosome organization
IR04_RS10905	COG4628	conserved protein (DUF2132)
IR04_RS10915	COG4120	Belongs to the binding-protein-dependent transport system permease family
IR04_RS10925	COG2203	Gaf domain
IR04_RS10925	COG2199	diguanylate cyclase activity
IR04_RS10930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR04_RS10940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IR04_RS10945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IR04_RS10950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IR04_RS10955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR04_RS10960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IR04_RS10965	COG0156	8-amino-7-oxononanoate synthase activity
IR04_RS10970	COG2226	methyltransferase
IR04_RS10975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IR04_RS10985	COG0501	Belongs to the peptidase M48B family
IR04_RS10995	COG0300	oxidoreductase activity
IR04_RS11010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IR04_RS11020	COG2268	Band 7 protein
IR04_RS11030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IR04_RS11035	COG2915	High frequency lysogenization protein hflD homolog
IR04_RS11040	COG0482	sulfurtransferase activity
IR04_RS11045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR04_RS11050	COG2916	Histone family protein nucleoid-structuring protein H-NS
IR04_RS11055	COG1757	Na H antiporter
IR04_RS11060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IR04_RS11065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IR04_RS11070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IR04_RS11075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IR04_RS11075	COG0131	Imidazoleglycerol-phosphate dehydratase
IR04_RS11080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IR04_RS11085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IR04_RS11090	COG0107	imidazoleglycerol-phosphate synthase activity
IR04_RS11095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IR04_RS11095	COG0140	phosphoribosyl-ATP diphosphatase activity
IR04_RS11100	COG1187	pseudouridine synthase activity
IR04_RS11110	COG1278	Cold shock
IR04_RS11115	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IR04_RS11120	COG0542	response to heat
IR04_RS11125	COG3273	potassium ion transport
IR04_RS11125	COG2985	domain, Protein
IR04_RS11130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IR04_RS11135	COG1012	belongs to the aldehyde dehydrogenase family
IR04_RS11135	COG1454	alcohol dehydrogenase
IR04_RS11140	COG1737	Transcriptional regulator
IR04_RS11145	COG0076	glutamate decarboxylase activity
IR04_RS11155	COG2431	L-lysine efflux transmembrane transporter activity
IR04_RS11165	COG3070	regulator of competence-specific genes
IR04_RS11180	COG3852	Histidine kinase
IR04_RS11190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IR04_RS11205	COG0189	ligase activity
IR04_RS11205	COG4067	protein conserved in archaea
IR04_RS11210	COG0500	methyltransferase
IR04_RS11215	COG4106	trans-aconitate 2-methyltransferase activity
IR04_RS11220	COG1801	Protein of unknown function DUF72
IR04_RS11225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IR04_RS11230	COG1435	thymidine kinase activity
IR04_RS11240	COG0159	tryptophan synthase activity
IR04_RS11245	COG0133	tryptophan synthase activity
IR04_RS11250	COG0134	indole-3-glycerol-phosphate synthase activity
IR04_RS11250	COG0135	phosphoribosylanthranilate isomerase activity
IR04_RS11255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR04_RS11260	COG0512	Glutamine amidotransferase of anthranilate synthase
IR04_RS11265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IR04_RS11275	COG0613	PHP domain protein
IR04_RS11280	COG0009	L-threonylcarbamoyladenylate synthase
IR04_RS11285	COG1187	pseudouridine synthase activity
IR04_RS11290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IR04_RS11295	COG4988	ABC transporter
IR04_RS11300	COG0492	ferredoxin-NADP+ reductase activity
IR04_RS11310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IR04_RS11315	COG3706	GGDEF domain
IR04_RS11320	COG2949	membrane
IR04_RS11330	COG0281	malic enzyme
IR04_RS11340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IR04_RS11360	COG2885	chlorophyll binding
IR04_RS11375	COG0277	FAD linked oxidase domain protein
IR04_RS11375	COG0247	lactate metabolic process
IR04_RS11395	COG2986	histidine ammonia-lyase
IR04_RS11400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IR04_RS11405	COG0010	Belongs to the arginase family
IR04_RS11410	COG1228	amidohydrolase
IR04_RS11425	COG3099	Belongs to the UPF0263 family
IR04_RS11430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IR04_RS11440	COG5001	Diguanylate cyclase
IR04_RS11445	COG0417	DNA replication proofreading
IR04_RS11450	COG2197	response regulator
IR04_RS11455	COG0322	excinuclease ABC activity
IR04_RS11495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IR04_RS11500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR04_RS11500	COG0072	phenylalanine-tRNA ligase activity
IR04_RS11505	COG0776	regulation of translation
IR04_RS11545	COG1346	cytolysis
IR04_RS11550	COG1380	Effector of murein hydrolase LrgA
IR04_RS11555	COG2925	Exonuclease
IR04_RS11560	COG1823	symporter activity
IR04_RS11565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR04_RS11570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IR04_RS11575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IR04_RS11595	COG4139	cobalamin transport
IR04_RS11645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR04_RS11650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR04_RS11655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IR04_RS11665	COG1054	Belongs to the UPF0176 family
IR04_RS11675	COG2814	Major facilitator Superfamily
IR04_RS11685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR04_RS11710	COG2989	Protein conserved in bacteria
IR04_RS11715	COG3108	Peptidase M15
IR04_RS11720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR04_RS11735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IR04_RS11760	COG1846	Transcriptional regulator
IR04_RS11765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IR04_RS11770	COG0726	polysaccharide deacetylase
IR04_RS11775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IR04_RS11785	COG1447	Phosphotransferase system cellobiose-specific component IIA
IR04_RS11790	COG1486	melibiose metabolic process
IR04_RS11800	COG1609	Transcriptional regulator
IR04_RS11805	COG2943	transferase activity, transferring hexosyl groups
IR04_RS11810	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IR04_RS11815	COG0840	transmembrane signaling receptor activity
IR04_RS11830	COG1448	Aminotransferase
IR04_RS11840	COG3437	response regulator, receiver
IR04_RS11840	COG2770	Histidine kinase
IR04_RS11845	COG0351	phosphomethylpyrimidine kinase
IR04_RS11850	COG0017	Asparaginyl-tRNA synthetase
IR04_RS11855	COG0840	transmembrane signaling receptor activity
IR04_RS11860	COG0720	synthase
IR04_RS11865	COG1760	l-serine dehydratase
IR04_RS11870	COG0814	amino acid
IR04_RS11875	COG0494	nUDIX hydrolase
IR04_RS11880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IR04_RS11895	COG3106	COG3106 Predicted ATPase
IR04_RS11900	COG3768	UPF0283 membrane protein
IR04_RS11910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR04_RS11925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IR04_RS11935	COG0471	metal ion transport
IR04_RS11940	COG4191	Histidine kinase
IR04_RS11940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR04_RS11950	COG2990	Protein conserved in bacteria
IR04_RS11955	COG3713	MltA-interacting MipA family protein
IR04_RS11960	COG2205	protein histidine kinase activity
IR04_RS11965	COG0745	RESPONSE REGULATOR receiver
IR04_RS12000	COG1129	ABC transporter
IR04_RS12040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IR04_RS12045	COG0372	Belongs to the citrate synthase family
IR04_RS12075	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR04_RS12085	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IR04_RS12095	COG0625	glutathione transferase activity
IR04_RS12100	COG3437	response regulator, receiver
IR04_RS12120	COG3706	GGDEF domain
IR04_RS12125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IR04_RS12130	COG1254	Belongs to the acylphosphatase family
IR04_RS12135	COG2920	part of a sulfur-relay system
IR04_RS12140	COG0670	Belongs to the BI1 family
IR04_RS12150	COG0765	amino acid transport
IR04_RS12155	COG4597	amino acid ABC transporter
IR04_RS12160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR04_RS12170	COG0561	phosphatase activity
IR04_RS12175	COG0602	queuosine metabolic process
IR04_RS12180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IR04_RS12210	COG3706	GGDEF domain
IR04_RS12215	COG0443	Heat shock 70 kDa protein
IR04_RS12220	COG0443	Heat shock 70 kDa protein
IR04_RS12260	COG1643	Atp-dependent helicase
IR04_RS12270	COG0443	Heat shock 70 kDa protein
IR04_RS12285	COG0583	DNA-binding transcription factor activity
IR04_RS12290	COG0477	Major facilitator Superfamily
IR04_RS12295	COG0415	Belongs to the DNA photolyase family
IR04_RS12310	COG0745	RESPONSE REGULATOR receiver
IR04_RS12320	COG2198	Histidine kinase
IR04_RS12320	COG0643	Histidine kinase
IR04_RS12325	COG0643	Histidine kinase
IR04_RS12325	COG0784	Response regulator, receiver
IR04_RS12325	COG2198	Histidine kinase
IR04_RS12330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IR04_RS12340	COG2201	protein-glutamate methylesterase activity
IR04_RS12345	COG0835	chemotaxis
IR04_RS12355	COG0840	transmembrane signaling receptor activity
IR04_RS12365	COG0513	Belongs to the DEAD box helicase family
IR04_RS12375	COG1538	Outer membrane efflux protein
IR04_RS12380	COG1566	PFAM secretion protein HlyD family protein
IR04_RS12385	COG2814	Major facilitator Superfamily
IR04_RS12395	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IR04_RS12405	COG3501	Rhs element vgr protein
IR04_RS12415	COG3675	Pfam Lipase (class 3)
IR04_RS12430	COG1280	lysine exporter protein (LysE YggA)
IR04_RS12435	COG1115	amino acid carrier protein
IR04_RS12450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IR04_RS12460	COG1177	transmembrane transport
IR04_RS12470	COG3842	ATPase activity
IR04_RS12495	COG0589	response to stress
IR04_RS12500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR04_RS12515	COG2217	Heavy metal translocating P-type atpase
IR04_RS12525	COG2010	Cytochrome c
IR04_RS12540	COG3278	Belongs to the heme-copper respiratory oxidase family
IR04_RS12555	COG2205	protein histidine kinase activity
IR04_RS12555	COG0784	Response regulator, receiver
IR04_RS12580	COG2994	toxin metabolic process
IR04_RS12585	COG1073	alpha beta
IR04_RS12585	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IR04_RS12585	COG3064	Membrane
IR04_RS12605	COG1476	TRANSCRIPTIONal
IR04_RS12620	COG4128	Pfam Zonular occludens toxin
IR04_RS12650	COG1476	TRANSCRIPTIONal
IR04_RS12735	COG3120	sequence-specific DNA binding
IR04_RS12740	COG1067	ATP-dependent peptidase activity
IR04_RS12745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IR04_RS12760	COG0488	(ABC) transporter
IR04_RS12770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IR04_RS12770	COG0116	Belongs to the methyltransferase superfamily
IR04_RS12780	COG0167	dihydroorotate dehydrogenase activity
IR04_RS12795	COG0308	aminopeptidase N
IR04_RS12810	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IR04_RS12815	COG1956	GAF domain-containing protein
IR04_RS12820	COG1132	(ABC) transporter
IR04_RS12825	COG2995	paraquat-inducible protein a
IR04_RS12830	COG3008	intermembrane lipid transfer
IR04_RS12840	COG2996	Protein conserved in bacteria
IR04_RS12855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IR04_RS12860	COG1666	GTP binding
IR04_RS12865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IR04_RS12880	COG0437	4 iron, 4 sulfur cluster binding
IR04_RS12885	COG3383	formate dehydrogenase (NAD+) activity
IR04_RS12885	COG0243	molybdopterin cofactor binding
IR04_RS12915	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IR04_RS12920	COG0488	(ABC) transporter
IR04_RS12925	COG3852	Histidine kinase
IR04_RS12930	COG2204	response regulator
IR04_RS12940	COG4662	Binding-protein-dependent transport system inner membrane component
IR04_RS12945	COG3842	ATPase activity
IR04_RS12950	COG0746	molybdenum cofactor guanylyltransferase activity
IR04_RS12980	COG1940	carbohydrate kinase activity
IR04_RS12985	COG3148	PFAM DTW domain containing protein
IR04_RS12995	COG0840	transmembrane signaling receptor activity
IR04_RS13000	COG0791	NLP P60 protein
IR04_RS13020	COG0534	Mate efflux family protein
IR04_RS13030	COG1793	dna ligase
IR04_RS13040	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IR04_RS13045	COG0848	biopolymer transport protein
IR04_RS13050	COG0811	peptide transport
IR04_RS13055	COG0811	peptide transport
IR04_RS13070	COG1175	transmembrane transport
IR04_RS13075	COG0395	ABC-type sugar transport system, permease component
IR04_RS13080	COG3842	ATPase activity
IR04_RS13085	COG1349	DNA-binding transcription factor activity
IR04_RS13090	COG0584	glycerophosphoryl diester phosphodiesterase
IR04_RS13095	COG2731	YhcH YjgK YiaL family protein
IR04_RS13100	COG0251	oxidation-reduction process
IR04_RS13105	COG1609	Transcriptional regulator
IR04_RS13110	COG2723	6-phospho-beta-galactosidase activity
IR04_RS13120	COG0583	DNA-binding transcription factor activity
IR04_RS13140	COG0577	efflux transmembrane transporter activity
IR04_RS13140	COG1136	(ABC) transporter
IR04_RS13145	COG1136	(ABC) transporter
IR04_RS13145	COG0577	efflux transmembrane transporter activity
IR04_RS13150	COG4591	ABC-type transport system involved in lipoprotein release permease component
IR04_RS13150	COG1136	(ABC) transporter
IR04_RS13155	COG1294	oxidase, subunit
IR04_RS13160	COG1271	oxidase subunit
IR04_RS13200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IR04_RS13210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IR04_RS13260	COG2200	EAL domain
IR04_RS13260	COG2199	diguanylate cyclase activity
IR04_RS13270	COG2017	converts alpha-aldose to the beta-anomer
IR04_RS13275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IR04_RS13280	COG1085	galactose-1-phosphate uridylyltransferase
IR04_RS13320	COG0784	Response regulator, receiver
IR04_RS13320	COG0835	chemotaxis
IR04_RS13330	COG4565	transcriptional regulatory protein
IR04_RS13335	COG3290	protein histidine kinase activity
IR04_RS13350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR04_RS13370	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IR04_RS13375	COG3063	Type IV pilus biogenesis stability protein PilW
IR04_RS13385	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IR04_RS13390	COG1451	nucleotide metabolic process
IR04_RS13400	COG0583	DNA-binding transcription factor activity
IR04_RS13420	COG1538	Outer membrane efflux protein
IR04_RS13435	COG1748	Saccharopine dehydrogenase
IR04_RS13445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IR04_RS13455	COG0577	efflux transmembrane transporter activity
IR04_RS13460	COG4181	ATPase activity
IR04_RS13465	COG0534	Mate efflux family protein
IR04_RS13470	COG0702	epimerase
IR04_RS13480	COG2814	Major facilitator Superfamily
IR04_RS13485	COG1187	pseudouridine synthase activity
IR04_RS13490	COG1061	Type III restriction enzyme res subunit
IR04_RS13510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IR04_RS13515	COG5001	Diguanylate cyclase
IR04_RS13515	COG2203	Gaf domain
IR04_RS13515	COG3706	GGDEF domain
IR04_RS13515	COG4251	negative regulation of phosphorylation
IR04_RS13530	COG0840	transmembrane signaling receptor activity
IR04_RS13560	COG4934	collagen metabolic process
IR04_RS13575	COG2205	protein histidine kinase activity
IR04_RS13575	COG0784	Response regulator, receiver
IR04_RS13580	COG2239	Acts as a magnesium transporter
IR04_RS13590	COG0814	amino acid
IR04_RS13595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR04_RS13600	COG1131	(ABC) transporter
IR04_RS13605	COG0842	Transport permease protein
IR04_RS13615	COG3313	Fe-S protein
IR04_RS13625	COG4134	Bacterial extracellular solute-binding protein
IR04_RS13630	COG4135	transport system, permease component
IR04_RS13635	COG4136	ATPase activity
IR04_RS13640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IR04_RS13645	COG0564	pseudouridine synthase activity
IR04_RS13650	COG0733	neurotransmitter:sodium symporter activity
IR04_RS13660	COG0626	cystathionine gamma-synthase activity
IR04_RS13665	COG2818	Glycosylase
IR04_RS13680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR04_RS13695	COG1842	Phage shock protein A
IR04_RS13700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IR04_RS13710	COG4168	peptide transport system, permease
IR04_RS13725	COG4172	Belongs to the ABC transporter superfamily
IR04_RS13740	COG1227	inorganic diphosphatase activity
IR04_RS13760	COG0243	molybdopterin cofactor binding
IR04_RS13765	COG3005	denitrification pathway
IR04_RS13770	COG4459	periplasmic nitrate reductase
IR04_RS13780	COG2116	formate transmembrane transporter activity
IR04_RS13790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR04_RS13795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IR04_RS13810	COG1607	acyl-coa hydrolase
IR04_RS13815	COG2350	Protein conserved in bacteria
IR04_RS13825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR04_RS13830	COG0583	DNA-binding transcription factor activity
IR04_RS13845	COG0612	Peptidase, M16
IR04_RS13850	COG5001	Diguanylate cyclase
IR04_RS13855	COG1032	radical SAM domain protein
IR04_RS13875	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IR04_RS13885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IR04_RS13890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IR04_RS13895	COG0745	RESPONSE REGULATOR receiver
IR04_RS13900	COG3381	protein complex oligomerization
IR04_RS13905	COG1609	Transcriptional regulator
IR04_RS13910	COG3070	regulator of competence-specific genes
IR04_RS13930	COG0297	glycogen (starch) synthase activity
IR04_RS13935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IR04_RS13940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR04_RS13970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IR04_RS13975	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IR04_RS13980	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IR04_RS14005	COG1012	belongs to the aldehyde dehydrogenase family
IR04_RS14010	COG1309	transcriptional regulator
IR04_RS14035	COG0668	transmembrane transport
IR04_RS14040	COG2995	paraquat-inducible protein a
IR04_RS14045	COG3008	intermembrane lipid transfer
IR04_RS14045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IR04_RS14055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR04_RS14070	COG0582	viral genome integration into host DNA
IR04_RS14080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IR04_RS14100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IR04_RS14120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IR04_RS14140	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IR04_RS14145	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IR04_RS14150	COG1737	Transcriptional regulator
IR04_RS14155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR04_RS14160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IR04_RS14165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IR04_RS14170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IR04_RS14185	COG1940	carbohydrate kinase activity
IR04_RS14190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IR04_RS14205	COG2003	Belongs to the UPF0758 family
IR04_RS14225	COG3941	tape measure
IR04_RS14265	COG0488	(ABC) transporter
IR04_RS14340	COG0415	Belongs to the DNA photolyase family
IR04_RS14350	COG4628	conserved protein (DUF2132)
IR04_RS14355	COG3284	Transcriptional regulator
IR04_RS14360	COG1012	belongs to the aldehyde dehydrogenase family
IR04_RS14370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR04_RS14375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR04_RS14380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR04_RS14390	COG2207	Transcriptional regulator
IR04_RS14395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR04_RS14395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR04_RS14395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IR04_RS14400	COG1482	cell wall glycoprotein biosynthetic process
IR04_RS14410	COG5002	protein histidine kinase activity
IR04_RS14410	COG0784	Response regulator, receiver
IR04_RS14420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IR04_RS14430	COG2885	chlorophyll binding
IR04_RS14435	COG0823	Involved in the tonB-independent uptake of proteins
IR04_RS14450	COG0811	peptide transport
IR04_RS14455	COG0824	Thioesterase
IR04_RS14460	COG3790	cyd operon protein YbgE
IR04_RS14465	COG4890	Cyd operon protein YbgT
IR04_RS14470	COG1294	oxidase, subunit
IR04_RS14475	COG1271	oxidase subunit
IR04_RS14485	COG0632	four-way junction helicase activity
IR04_RS14490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IR04_RS14495	COG0215	cysteine-tRNA ligase activity
IR04_RS14500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IR04_RS14505	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR04_RS14510	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IR04_RS14515	COG3012	SEC-C Motif Domain Protein
IR04_RS14520	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IR04_RS14525	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IR04_RS14530	COG1199	ATP-dependent helicase activity
IR04_RS14535	COG0730	response to heat
IR04_RS14540	COG3923	Primosomal replication protein n
IR04_RS14550	COG0840	transmembrane signaling receptor activity
IR04_RS14555	COG0708	Exodeoxyribonuclease III
IR04_RS14560	COG4160	amino acid transport
IR04_RS14585	COG1882	Formate acetyltransferase
IR04_RS14595	COG0840	transmembrane signaling receptor activity
IR04_RS14600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IR04_RS14610	COG3013	Belongs to the UPF0304 family
IR04_RS14615	COG2766	serine protein kinase
IR04_RS14620	COG2718	Belongs to the UPF0229 family
IR04_RS14625	COG2719	SpoVR family
IR04_RS14630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IR04_RS14635	COG2835	tetraacyldisaccharide 4'-kinase activity
IR04_RS14640	COG1663	tetraacyldisaccharide 4'-kinase activity
IR04_RS14645	COG1132	(ABC) transporter
IR04_RS14650	COG2333	competence protein COMEC
IR04_RS14650	COG0658	competence protein
IR04_RS14660	COG4591	ABC-type transport system involved in lipoprotein release permease component
IR04_RS14665	COG1136	(ABC) transporter
IR04_RS14670	COG4591	ABC-type transport system involved in lipoprotein release permease component
IR04_RS14680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IR04_RS14700	COG1252	NADH dehydrogenase
IR04_RS14705	COG3150	esterase
IR04_RS14730	COG0537	adenosine 5'-monophosphoramidase activity
IR04_RS14745	COG2186	Transcriptional regulator
IR04_RS14750	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IR04_RS14755	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IR04_RS14760	COG1674	ftsk spoiiie
IR04_RS14770	COG0686	Belongs to the AlaDH PNT family
IR04_RS14780	COG0583	DNA-binding transcription factor activity
IR04_RS14800	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IR04_RS14805	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IR04_RS14810	COG0776	regulation of translation
IR04_RS14815	COG0539	negative regulation of cytoplasmic translation
IR04_RS14820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IR04_RS14825	COG1555	photosystem II stabilization
IR04_RS14830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR04_RS14835	COG0776	regulation of translation
IR04_RS14840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IR04_RS14845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IR04_RS14855	COG0544	peptidyl-prolyl cis-trans isomerase activity
IR04_RS14865	COG4191	Histidine kinase
IR04_RS14875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IR04_RS14880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IR04_RS14885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IR04_RS14890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IR04_RS14905	COG3300	MHYT domain
IR04_RS14905	COG5001	Diguanylate cyclase
IR04_RS14915	COG4589	Belongs to the CDS family
IR04_RS14950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IR04_RS14960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR04_RS14975	COG0243	molybdopterin cofactor binding
IR04_RS14980	COG3005	denitrification pathway
IR04_RS14985	COG3325	Belongs to the glycosyl hydrolase 18 family
IR04_RS14985	COG3469	chitinase activity
IR04_RS14990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IR04_RS15000	COG2951	lytic endotransglycosylase activity
IR04_RS15005	COG3100	YcgL domain-containing protein
IR04_RS15010	COG0850	regulation of cytokinetic process
IR04_RS15015	COG2894	cell division
IR04_RS15020	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IR04_RS15025	COG3015	lipoprotein NlpE involved in copper resistance
IR04_RS15045	COG0477	Major facilitator Superfamily
IR04_RS15055	COG0840	transmembrane signaling receptor activity
IR04_RS15060	COG1396	sequence-specific DNA binding
IR04_RS15065	COG3135	benzoate transporter
IR04_RS15085	COG0596	Alpha beta hydrolase
IR04_RS15090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IR04_RS15095	COG1169	isochorismate synthase
IR04_RS15100	COG0436	Aminotransferase
IR04_RS15105	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IR04_RS15110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IR04_RS15130	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IR04_RS15135	COG0318	PFAM AMP-dependent synthetase and ligase
IR04_RS15140	COG0596	Alpha beta hydrolase
IR04_RS15155	COG1214	PFAM Peptidase M22, glycoprotease
IR04_RS15160	COG1199	ATP-dependent helicase activity
IR04_RS15170	COG0788	formyltetrahydrofolate deformylase activity
IR04_RS15175	COG0446	pyridine nucleotide-disulphide oxidoreductase
IR04_RS15175	COG1902	pentaerythritol trinitrate reductase activity
IR04_RS15180	COG0616	signal peptide processing
IR04_RS15185	COG0252	asparaginase activity
IR04_RS15190	COG3139	Protein of unknown function (DUF1315)
IR04_RS15200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR04_RS15205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IR04_RS15210	COG0676	glucose-6-phosphate 1-epimerase activity
IR04_RS15220	COG2226	methyltransferase
IR04_RS15235	COG0835	chemotaxis
IR04_RS15235	COG0784	Response regulator, receiver
IR04_RS15240	COG1940	carbohydrate kinase activity
IR04_RS15250	COG4667	esterase of the alpha-beta hydrolase superfamily
IR04_RS15265	COG0733	neurotransmitter:sodium symporter activity
IR04_RS15270	COG1263	PTS System
IR04_RS15270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR04_RS15275	COG0084	hydrolase, TatD family'
IR04_RS15285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IR04_RS15290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IR04_RS15295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IR04_RS15300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR04_RS15305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IR04_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
IR04_RS15320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR04_RS15325	COG0416	fatty acid biosynthetic process
IR04_RS15330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IR04_RS15335	COG1399	metal-binding, possibly nucleic acid-binding protein
IR04_RS15340	COG0424	maF-like protein
IR04_RS15345	COG0564	pseudouridine synthase activity
IR04_RS15360	COG1530	ribonuclease E activity
IR04_RS15365	COG0659	secondary active sulfate transmembrane transporter activity
IR04_RS15375	COG1454	alcohol dehydrogenase
IR04_RS15375	COG1012	belongs to the aldehyde dehydrogenase family
IR04_RS15380	COG2095	MarC family integral membrane protein
IR04_RS15385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IR04_RS15390	COG1757	Na H antiporter
IR04_RS15400	COG3081	Nucleoid-associated protein
IR04_RS15405	COG3082	Protein of unknown function (DUF1414)
IR04_RS15410	COG3083	sulfuric ester hydrolase activity
IR04_RS15425	COG0123	including yeast histone deacetylase and acetoin utilization protein
IR04_RS15430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR04_RS15435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IR04_RS15455	COG2853	Lipoprotein
IR04_RS15465	COG3088	subunit of a heme lyase
IR04_RS15465	COG4235	cytochrome complex assembly
IR04_RS15470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR04_RS15475	COG1138	Cytochrome C-type biogenesis protein
IR04_RS15480	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IR04_RS15490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR04_RS15495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR04_RS15500	COG4133	protoheme IX ABC transporter activity
IR04_RS15510	COG0835	chemotaxis
IR04_RS15520	COG1192	Involved in chromosome partitioning
IR04_RS15525	COG2201	protein-glutamate methylesterase activity
IR04_RS15530	COG2198	Histidine kinase
IR04_RS15530	COG0643	Histidine kinase
IR04_RS15530	COG0784	Response regulator, receiver
IR04_RS15535	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IR04_RS15565	COG2062	phosphohistidine phosphatase, SixA
IR04_RS15570	COG1025	Belongs to the peptidase M16 family
IR04_RS15580	COG0018	arginyl-trna synthetase
IR04_RS15600	COG1918	ferrous iron import across plasma membrane
IR04_RS15605	COG4977	sequence-specific DNA binding
IR04_RS15610	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IR04_RS15615	COG1121	(ABC) transporter
IR04_RS15620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR04_RS15630	COG0045	succinate-CoA ligase (ADP-forming) activity
IR04_RS15635	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR04_RS15640	COG0567	Dehydrogenase, E1 component
IR04_RS15650	COG1053	succinate dehydrogenase
IR04_RS15655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IR04_RS15660	COG2009	succinate dehydrogenase
IR04_RS15665	COG0372	Belongs to the citrate synthase family
IR04_RS15670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IR04_RS15680	COG0033	Phosphoglucomutase
IR04_RS15685	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IR04_RS15690	COG0596	Alpha beta hydrolase
IR04_RS15705	COG1346	cytolysis
IR04_RS15715	COG0583	DNA-binding transcription factor activity
IR04_RS15725	COG0735	belongs to the Fur family
IR04_RS15730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IR04_RS15735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR04_RS15740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR04_RS15750	COG0431	NADPH-dependent FMN reductase
IR04_RS15760	COG3101	peptidyl-lysine hydroxylation
IR04_RS15765	COG2860	membrane
IR04_RS15770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IR04_RS15780	COG2890	protein-(glutamine-N5) methyltransferase activity
IR04_RS15785	COG2840	Smr protein MutS2
IR04_RS15795	COG1684	flagellar biosynthetic protein fliR
IR04_RS15800	COG1987	bacterial-type flagellum assembly
IR04_RS15825	COG1580	Controls the rotational direction of flagella during chemotaxis
IR04_RS15845	COG1317	bacterial-type flagellum organization
IR04_RS15850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR04_RS15860	COG1677	Flagellar hook-basal body complex protein FliE
IR04_RS15880	COG1516	flagellar protein fliS
IR04_RS15890	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IR04_RS15895	COG1334	flagellar protein FlaG
IR04_RS15900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR04_RS15905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR04_RS15910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR04_RS15915	COG2837	iron assimilation
IR04_RS15935	COG1393	Belongs to the ArsC family
IR04_RS15945	COG1876	peptidase activity
IR04_RS15955	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IR04_RS15970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IR04_RS15990	COG4783	chaperone-mediated protein folding
IR04_RS15995	COG1393	Belongs to the ArsC family
IR04_RS16015	COG2233	PERMEase
IR04_RS16020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR04_RS16025	COG0737	Belongs to the 5'-nucleotidase family
IR04_RS16030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IR04_RS16035	COG2912	Transglutaminase-like superfamily
IR04_RS16045	COG2890	protein-(glutamine-N5) methyltransferase activity
IR04_RS16050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IR04_RS16055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IR04_RS16060	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IR04_RS16065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IR04_RS16070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IR04_RS16075	COG0193	aminoacyl-tRNA hydrolase activity
IR04_RS16080	COG0012	GTP binding
IR04_RS16165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR04_RS16170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR04_RS16190	COG1705	Flagellar rod assembly protein muramidase FlgJ
IR04_RS16190	COG3951	Flagellar rod assembly protein muramidase FlgJ
IR04_RS16195	COG1706	bacterial-type flagellum-dependent cell motility
IR04_RS16200	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IR04_RS16210	COG4787	bacterial-type flagellum-dependent cell motility
IR04_RS16215	COG1749	Flagellar hook protein flgE
IR04_RS16230	COG1815	bacterial-type flagellum-dependent cell motility
IR04_RS16235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IR04_RS16240	COG0835	chemotaxis
IR04_RS16240	COG0784	Response regulator, receiver
IR04_RS16275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IR04_RS16275	COG2226	methyltransferase
IR04_RS16275	COG3433	isochorismatase activity
IR04_RS16280	COG2375	cellular response to nickel ion
IR04_RS16285	COG4774	siderophore transport
IR04_RS16285	COG1629	transport
IR04_RS16300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR04_RS16305	COG2217	Heavy metal translocating P-type atpase
IR04_RS16305	COG2608	mercury ion transmembrane transporter activity
IR04_RS16320	COG3735	TraB family
IR04_RS16335	COG2840	Smr protein MutS2
IR04_RS16340	COG1187	pseudouridine synthase activity
IR04_RS16350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IR04_RS16355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IR04_RS16360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IR04_RS16365	COG0121	glutamine amidotransferase
IR04_RS16370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IR04_RS16375	COG1960	acyl-CoA dehydrogenase activity
IR04_RS16390	COG0328	RNA-DNA hybrid ribonuclease activity
IR04_RS16395	COG2226	methyltransferase
IR04_RS16400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR04_RS16405	COG1388	LysM domain
IR04_RS16405	COG0741	lytic transglycosylase activity
IR04_RS16410	COG3021	interspecies interaction between organisms
IR04_RS16415	COG0347	Belongs to the P(II) protein family
IR04_RS16420	COG3479	Phenolic acid decarboxylase
IR04_RS16430	COG0037	tRNA processing
IR04_RS16435	COG0825	malonyl-CoA metabolic process
IR04_RS16440	COG0587	DNA-directed DNA polymerase activity
IR04_RS16445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IR04_RS16450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR04_RS16455	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR04_RS16460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IR04_RS16465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR04_RS16470	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IR04_RS16480	COG0750	zinc metalloprotease
IR04_RS16485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IR04_RS16490	COG0575	Belongs to the CDS family
IR04_RS16495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IR04_RS16500	COG0233	cytoplasmic translational termination
IR04_RS16505	COG0528	UMP kinase activity
IR04_RS16510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IR04_RS16515	COG0052	Belongs to the universal ribosomal protein uS2 family
IR04_RS16520	COG0024	Methionine aminopeptidase
IR04_RS16525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IR04_RS16535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IR04_RS16540	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IR04_RS16545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR04_RS16550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IR04_RS16565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR04_RS16565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR04_RS16570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IR04_RS16575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IR04_RS16580	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IR04_RS16590	COG1073	alpha beta
IR04_RS16595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IR04_RS16600	COG2252	PERMEase
IR04_RS16605	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR04_RS16610	COG0189	ligase activity
IR04_RS16610	COG4067	protein conserved in archaea
IR04_RS16615	COG0189	ligase activity
IR04_RS16625	COG0733	neurotransmitter:sodium symporter activity
IR04_RS16630	COG3706	GGDEF domain
IR04_RS16635	COG3328	transposase activity
IR04_RS16665	COG1477	protein flavinylation
IR04_RS16670	COG2871	sodium ion transport
IR04_RS16675	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR04_RS16680	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR04_RS16685	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR04_RS16690	COG1805	sodium ion transport
IR04_RS16695	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR04_RS16700	COG0271	Belongs to the BolA IbaG family
IR04_RS16705	COG2813	Specifically methylates the guanine in position
IR04_RS16715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IR04_RS16720	COG2211	Major facilitator Superfamily
IR04_RS16730	COG1595	DNA-templated transcription, initiation
IR04_RS16740	COG3248	Nucleoside-binding outer membrane protein
IR04_RS16745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IR04_RS16750	COG0693	protein deglycase activity
IR04_RS16755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IR04_RS16760	COG2166	iron-sulfur cluster assembly
IR04_RS16765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IR04_RS16770	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IR04_RS16780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IR04_RS16780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IR04_RS16795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IR04_RS16800	COG1074	ATP-dependent DNA helicase activity
IR04_RS16805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IR04_RS16820	COG3141	response to X-ray
IR04_RS16825	COG2171	N-acyltransferase activity
IR04_RS16835	COG0456	acetyltransferase
IR04_RS16840	COG0189	ligase activity
IR04_RS16840	COG0569	domain protein
IR04_RS16855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR04_RS16860	COG1609	Transcriptional regulator
IR04_RS16865	COG3250	beta-galactosidase activity
IR04_RS16880	COG1022	Amp-dependent synthetase and ligase
IR04_RS16885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IR04_RS16890	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IR04_RS16900	COG0560	Phosphoserine phosphatase
IR04_RS16910	COG0813	purine-nucleoside phosphorylase activity
IR04_RS16915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IR04_RS16920	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IR04_RS16925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IR04_RS16935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IR04_RS16940	COG0084	hydrolase, TatD family'
IR04_RS16945	COG3022	response to hydroperoxide
IR04_RS16950	COG1115	amino acid carrier protein
IR04_RS16965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IR04_RS16970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IR04_RS16975	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IR04_RS16980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IR04_RS17000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IR04_RS17010	COG0745	RESPONSE REGULATOR receiver
IR04_RS17015	COG2198	Histidine kinase
IR04_RS17015	COG0784	Response regulator, receiver
IR04_RS17015	COG5002	protein histidine kinase activity
IR04_RS17020	COG2203	Gaf domain
IR04_RS17020	COG3706	GGDEF domain
IR04_RS17020	COG5001	Diguanylate cyclase
IR04_RS17020	COG4251	negative regulation of phosphorylation
IR04_RS17025	COG1242	4 iron, 4 sulfur cluster binding
IR04_RS17030	COG0067	glutamate synthase
IR04_RS17030	COG0070	glutamate synthase
IR04_RS17030	COG0069	glutamate synthase activity
IR04_RS17040	COG0069	glutamate synthase activity
IR04_RS17040	COG0067	glutamate synthase
IR04_RS17040	COG0070	glutamate synthase
IR04_RS17045	COG0493	'glutamate synthase
IR04_RS17055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IR04_RS17065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IR04_RS17070	COG2860	membrane
IR04_RS17075	COG0583	DNA-binding transcription factor activity
IR04_RS17080	COG0730	response to heat
IR04_RS17090	COG4172	Belongs to the ABC transporter superfamily
IR04_RS17110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IR04_RS17115	COG0505	Belongs to the CarA family
IR04_RS17125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IR04_RS17130	COG0494	nUDIX hydrolase
IR04_RS17140	COG0653	protein targeting
IR04_RS17150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IR04_RS17155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IR04_RS17160	COG0849	cell division
IR04_RS17165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IR04_RS17170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IR04_RS17180	COG0772	Belongs to the SEDS family
IR04_RS17185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IR04_RS17195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IR04_RS17200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IR04_RS17205	COG0768	penicillin binding
IR04_RS17210	COG3116	cell division
IR04_RS17220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR04_RS17225	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR04_RS17230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IR04_RS17235	COG2186	Transcriptional regulator
IR04_RS17240	COG0737	Belongs to the 5'-nucleotidase family
IR04_RS17245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IR04_RS17250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IR04_RS17255	COG4974	Belongs to the 'phage' integrase family
IR04_RS17260	COG0716	FMN binding
IR04_RS17280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR04_RS17285	COG1459	type II secretion system
IR04_RS17295	COG0237	dephospho-CoA kinase activity
IR04_RS17300	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IR04_RS17310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IR04_RS17315	COG0187	DNA topoisomerase II activity
IR04_RS17320	COG3150	esterase
IR04_RS17330	COG3151	Protein conserved in bacteria
IR04_RS17335	COG0494	nUDIX hydrolase
IR04_RS17340	COG1538	Outer membrane efflux protein
IR04_RS17350	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IR04_RS17355	COG0840	transmembrane signaling receptor activity
IR04_RS17360	COG3025	triphosphatase activity
IR04_RS17365	COG1392	Phosphate transport regulator
IR04_RS17370	COG0306	phosphate transporter
IR04_RS17375	COG4991	sh3 domain protein
IR04_RS17385	COG3409	Peptidoglycan-binding domain 1 protein
IR04_RS17385	COG3267	Type II secretory pathway component ExeA
IR04_RS17395	COG0148	phosphopyruvate hydratase activity
IR04_RS17400	COG0504	CTP synthase activity
IR04_RS17405	COG3956	TIGRFAM MazG family protein
IR04_RS17410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR04_RS17425	COG5001	Diguanylate cyclase
IR04_RS17445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IR04_RS17450	COG1381	Involved in DNA repair and RecF pathway recombination
IR04_RS17455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IR04_RS17470	COG0481	GTPase activity
IR04_RS17475	COG3086	response to oxidative stress
IR04_RS17490	COG1595	DNA-templated transcription, initiation
IR04_RS17500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IR04_RS17510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IR04_RS17525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR04_RS17530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR04_RS17535	COG3079	Belongs to the UPF0149 family
IR04_RS17540	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IR04_RS17550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IR04_RS17555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR04_RS17560	COG0440	acetolactate synthase activity
IR04_RS17565	COG0028	Belongs to the TPP enzyme family
IR04_RS17570	COG1022	Amp-dependent synthetase and ligase
IR04_RS17575	COG0583	DNA-binding transcription factor activity
IR04_RS17600	COG0473	3-isopropylmalate dehydrogenase activity
IR04_RS17605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IR04_RS17610	COG0066	3-isopropylmalate dehydratase activity
IR04_RS17655	COG3437	response regulator, receiver
IR04_RS17670	COG0795	lipopolysaccharide-transporting ATPase activity
IR04_RS17675	COG0795	lipopolysaccharide-transporting ATPase activity
IR04_RS17680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR04_RS17685	COG2927	DNA polymerase III (CHI subunit)
IR04_RS17690	COG0525	valine-tRNA ligase activity
IR04_RS17695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR04_RS17700	COG0564	pseudouridine synthase activity
IR04_RS17715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IR04_RS17730	COG0540	Belongs to the ATCase OTCase family
IR04_RS17740	COG0251	oxidation-reduction process
IR04_RS17750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IR04_RS17755	COG5007	Belongs to the BolA IbaG family
IR04_RS17765	COG2854	intermembrane phospholipid transfer
IR04_RS17770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IR04_RS17775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IR04_RS17780	COG1127	ABC transporter
IR04_RS17795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IR04_RS17795	COG0517	IMP dehydrogenase activity
IR04_RS17810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IR04_RS17815	COG1137	ATPase activity
IR04_RS17825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IR04_RS17830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR04_RS17835	COG1660	Displays ATPase and GTPase activities
IR04_RS17840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR04_RS17845	COG2239	Acts as a magnesium transporter
IR04_RS17850	COG0312	modulator of DNA gyrase
IR04_RS17855	COG3028	Belongs to the UPF0307 family
IR04_RS17860	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IR04_RS17865	COG1178	ABC-type Fe3 transport system permease component
IR04_RS17875	COG0163	prenyltransferase activity
IR04_RS17880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IR04_RS17895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IR04_RS17900	COG2105	PFAM AIG2 family protein
IR04_RS17910	COG0729	surface antigen
IR04_RS17915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR04_RS17920	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IR04_RS17935	COG1136	(ABC) transporter
IR04_RS17955	COG0529	Catalyzes the synthesis of activated sulfate
IR04_RS17970	COG1648	precorrin-2 dehydrogenase activity
IR04_RS17970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IR04_RS17975	COG0737	Belongs to the 5'-nucleotidase family
IR04_RS17985	COG0513	Belongs to the DEAD box helicase family
IR04_RS17990	COG2153	protein acetylation
IR04_RS17995	COG0697	spore germination
IR04_RS18005	COG0545	Peptidyl-prolyl cis-trans isomerase
IR04_RS18015	COG0203	ribosomal protein L17
IR04_RS18020	COG0202	RNA polymerase activity
IR04_RS18025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IR04_RS18030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IR04_RS18035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IR04_RS18040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IR04_RS18045	COG0201	protein transport
IR04_RS18055	COG1841	ribosomal large subunit assembly
IR04_RS18060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IR04_RS18065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IR04_RS18075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IR04_RS18080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IR04_RS18085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IR04_RS18090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IR04_RS18095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IR04_RS18100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IR04_RS18105	COG0255	Belongs to the universal ribosomal protein uL29 family
IR04_RS18110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IR04_RS18115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IR04_RS18120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IR04_RS18125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IR04_RS18130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IR04_RS18135	COG0089	rRNA binding
IR04_RS18140	COG0088	Forms part of the polypeptide exit tunnel
IR04_RS18145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IR04_RS18150	COG0051	transcription antitermination factor activity, RNA binding
IR04_RS18160	COG0557	exoribonuclease II activity
IR04_RS18165	COG3083	sulfuric ester hydrolase activity
IR04_RS18170	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IR04_RS18185	COG1047	Peptidyl-prolyl cis-trans
IR04_RS18200	COG2249	NAD(P)H dehydrogenase (quinone) activity
IR04_RS18205	COG0488	(ABC) transporter
IR04_RS18215	COG0429	hydrolase of the alpha beta-hydrolase fold
IR04_RS18225	COG3954	Phosphoribulokinase
IR04_RS18250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IR04_RS18260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR04_RS18275	COG0180	Tryptophanyl-tRNA synthetase
IR04_RS18280	COG0546	phosphoglycolate phosphatase activity
IR04_RS18285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IR04_RS18290	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IR04_RS18300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IR04_RS18305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IR04_RS18335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IR04_RS18345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IR04_RS18345	COG0678	peroxiredoxin activity
IR04_RS18350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR04_RS18360	COG0165	Argininosuccinate lyase
IR04_RS18365	COG0137	argininosuccinate synthase activity
IR04_RS18370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IR04_RS18375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IR04_RS18380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR04_RS18385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IR04_RS18395	COG1045	serine acetyltransferase
IR04_RS18400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IR04_RS18405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IR04_RS18410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR04_RS18415	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IR04_RS18420	COG1053	succinate dehydrogenase
IR04_RS18425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IR04_RS18430	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IR04_RS18440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IR04_RS18445	COG1509	lysine 2,3-aminomutase activity
IR04_RS18455	COG0459	protein refolding
IR04_RS18460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IR04_RS18485	COG0149	triose-phosphate isomerase activity
IR04_RS18490	COG0534	Mate efflux family protein
IR04_RS18495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IR04_RS18500	COG1575	Belongs to the MenA family. Type 1 subfamily
IR04_RS18505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IR04_RS18510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IR04_RS18515	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IR04_RS18520	COG1609	Transcriptional regulator
IR04_RS18525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IR04_RS18530	COG0254	rRNA binding
IR04_RS18535	COG0281	malic enzyme
IR04_RS18540	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IR04_RS18545	COG0626	cystathionine gamma-synthase activity
IR04_RS18550	COG0460	homoserine dehydrogenase
IR04_RS18550	COG0527	aspartate kinase activity
IR04_RS18555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IR04_RS18560	COG3074	FtsZ-dependent cytokinesis
IR04_RS18565	COG1494	fructose-1,6-bisphosphatase
IR04_RS18570	COG0205	6-phosphofructokinase activity
IR04_RS18575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IR04_RS18585	COG0745	RESPONSE REGULATOR receiver
IR04_RS18590	COG2205	protein histidine kinase activity
IR04_RS18600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IR04_RS18605	COG3030	protein affecting phage T7 exclusion by the F plasmid
IR04_RS18610	COG3706	GGDEF domain
IR04_RS18615	COG1027	Aspartate ammonia-lyase
IR04_RS18620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IR04_RS18635	COG4232	protein-disulfide reductase activity
IR04_RS18655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IR04_RS18660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IR04_RS18665	COG0194	GDP metabolic process
IR04_RS18670	COG1758	RNA polymerase activity
IR04_RS18675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR04_RS18680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IR04_RS18685	COG2233	PERMEase
IR04_RS18700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR04_RS18705	COG2183	response to ionizing radiation
IR04_RS18715	COG0596	Alpha beta hydrolase
IR04_RS18720	COG1040	competence protein
IR04_RS18730	COG0494	nUDIX hydrolase
IR04_RS18735	COG1218	3'(2'),5'-bisphosphate nucleotidase
IR04_RS18745	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IR04_RS18750	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IR04_RS18755	COG3156	type II secretion system protein K
IR04_RS18760	COG4795	General secretion pathway protein
IR04_RS18765	COG2165	general secretion pathway protein
IR04_RS18770	COG2165	general secretion pathway protein
IR04_RS18775	COG2165	general secretion pathway protein
IR04_RS18780	COG1459	type II secretion system
IR04_RS18785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR04_RS18795	COG3031	protein transport across the cell outer membrane
IR04_RS18800	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IR04_RS18805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IR04_RS18810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IR04_RS18820	COG0456	acetyltransferase
IR04_RS18825	COG1490	D-aminoacyl-tRNA deacylase activity
IR04_RS18830	COG1295	ribonuclease BN
IR04_RS18840	COG1217	gtp-binding protein TYPA
IR04_RS18850	COG0174	glutamine synthetase
IR04_RS18860	COG3852	Histidine kinase
IR04_RS18870	COG5001	Diguanylate cyclase
IR04_RS18870	COG3300	MHYT domain
IR04_RS18875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IR04_RS18940	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IR04_RS18945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR04_RS18950	COG1739	Uncharacterized protein family UPF0029
IR04_RS18960	COG0183	Belongs to the thiolase family
IR04_RS18965	COG0583	DNA-binding transcription factor activity
IR04_RS18970	COG2814	Major facilitator Superfamily
IR04_RS18975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IR04_RS18980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IR04_RS18985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IR04_RS18990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IR04_RS18995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IR04_RS19000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IR04_RS19005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IR04_RS19015	COG0356	it plays a direct role in the translocation of protons across the membrane
IR04_RS19020	COG3312	ion transport
IR04_RS19025	COG1475	DNA binding
IR04_RS19030	COG1192	Involved in chromosome partitioning
IR04_RS19040	COG0445	tRNA wobble uridine modification