locus-tag	class	description
HJ37_RS00005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HJ37_RS00010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HJ37_RS00020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJ37_RS00030	COG1489	DNA binding
HJ37_RS00040	COG1643	Atp-dependent helicase
HJ37_RS00045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HJ37_RS00050	COG1752	Esterase of the alpha-beta hydrolase superfamily
HJ37_RS00055	COG1049	propionate catabolic process, 2-methylcitrate cycle
HJ37_RS00060	COG3112	Uncharacterised protein family (UPF0231)
HJ37_RS00065	COG0347	Belongs to the P(II) protein family
HJ37_RS00070	COG0004	ammonium transporteR
HJ37_RS00075	COG1840	ABC-type Fe3 transport system, periplasmic component
HJ37_RS00085	COG3842	ATPase activity
HJ37_RS00105	COG2971	BadF BadG BcrA BcrD
HJ37_RS00115	COG4608	Belongs to the ABC transporter superfamily
HJ37_RS00120	COG0444	Belongs to the ABC transporter superfamily
HJ37_RS00125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJ37_RS00130	COG0601	transmembrane transport
HJ37_RS00135	COG0747	negative chemotaxis
HJ37_RS00145	COG2205	protein histidine kinase activity
HJ37_RS00145	COG0784	Response regulator, receiver
HJ37_RS00150	COG2813	Specifically methylates the guanine in position
HJ37_RS00155	COG0628	permease
HJ37_RS00165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HJ37_RS00170	COG0316	Belongs to the HesB IscA family
HJ37_RS00185	COG0739	heme binding
HJ37_RS00190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HJ37_RS00195	COG2027	D-alanyl-D-alanine carboxypeptidase
HJ37_RS00200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HJ37_RS00205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HJ37_RS00210	COG1534	Rna-binding protein
HJ37_RS00215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HJ37_RS00220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HJ37_RS00225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HJ37_RS00235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HJ37_RS00250	COG0779	Required for maturation of 30S ribosomal subunits
HJ37_RS00255	COG0195	Participates in both transcription termination and antitermination
HJ37_RS00260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HJ37_RS00265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HJ37_RS00275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HJ37_RS00300	COG0826	peptidase U32
HJ37_RS00305	COG0826	peptidase U32
HJ37_RS00315	COG3154	lipid carrier protein
HJ37_RS00320	COG3153	acetyltransferase
HJ37_RS00435	COG3328	transposase activity
HJ37_RS00450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HJ37_RS00585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HJ37_RS00600	COG0681	Belongs to the peptidase S26 family
HJ37_RS00640	COG2356	endonuclease I
HJ37_RS00655	COG0629	single-stranded DNA binding
HJ37_RS00670	COG0714	Associated with various cellular activities
HJ37_RS00695	COG2003	Belongs to the UPF0758 family
HJ37_RS00810	COG0513	Belongs to the DEAD box helicase family
HJ37_RS00825	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HJ37_RS00830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HJ37_RS00835	COG2204	response regulator
HJ37_RS00845	COG0667	Aldo Keto reductase
HJ37_RS00860	COG0494	nUDIX hydrolase
HJ37_RS00865	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HJ37_RS00870	COG0730	response to heat
HJ37_RS00875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HJ37_RS00885	COG1283	sodium-dependent phosphate transmembrane transporter activity
HJ37_RS00890	COG0583	DNA-binding transcription factor activity
HJ37_RS00895	COG0640	Transcriptional regulator
HJ37_RS00900	COG0268	Binds directly to 16S ribosomal RNA
HJ37_RS00905	COG0728	peptidoglycan biosynthetic process
HJ37_RS00910	COG0196	riboflavin kinase activity
HJ37_RS00925	COG1047	Peptidyl-prolyl cis-trans
HJ37_RS00930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HJ37_RS00935	COG1966	Carbon starvation protein
HJ37_RS00950	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HJ37_RS00955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HJ37_RS00965	COG3279	Response regulator of the LytR AlgR family
HJ37_RS00970	COG3275	phosphorelay sensor kinase activity
HJ37_RS00975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HJ37_RS00980	COG1605	Chorismate mutase
HJ37_RS00980	COG0287	Prephenate dehydrogenase
HJ37_RS00990	COG0488	(ABC) transporter
HJ37_RS01000	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HJ37_RS01010	COG5001	Diguanylate cyclase
HJ37_RS01015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HJ37_RS01020	COG0077	Prephenate dehydratase
HJ37_RS01020	COG1605	Chorismate mutase
HJ37_RS01025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HJ37_RS01030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJ37_RS01035	COG0564	pseudouridine synthase activity
HJ37_RS01045	COG0542	response to heat
HJ37_RS01085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HJ37_RS01090	COG0826	peptidase U32
HJ37_RS01100	COG0745	RESPONSE REGULATOR receiver
HJ37_RS01105	COG5002	protein histidine kinase activity
HJ37_RS01115	COG0248	Ppx GppA phosphatase
HJ37_RS01120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HJ37_RS01130	COG0581	inorganic phosphate transmembrane transporter activity
HJ37_RS01135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HJ37_RS01150	COG3142	Participates in the control of copper homeostasis
HJ37_RS01155	COG0450	alkyl hydroperoxide reductase
HJ37_RS01160	COG0583	DNA-binding transcription factor activity
HJ37_RS01165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HJ37_RS01175	COG0517	IMP dehydrogenase activity
HJ37_RS01195	COG1862	Preprotein translocase
HJ37_RS01200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HJ37_RS01205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HJ37_RS01210	COG0483	inositol monophosphate 1-phosphatase activity
HJ37_RS01220	COG1959	2 iron, 2 sulfur cluster binding
HJ37_RS01225	COG1104	cysteine desulfurase activity
HJ37_RS01230	COG0822	iron-sulfur transferase activity
HJ37_RS01240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HJ37_RS01245	COG0443	Heat shock 70 kDa protein
HJ37_RS01250	COG0633	Ferredoxin
HJ37_RS01255	COG2975	iron-sulfur cluster assembly
HJ37_RS01260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HJ37_RS01265	COG0105	UTP biosynthetic process
HJ37_RS01270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HJ37_RS01280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HJ37_RS01285	COG0124	histidyl-tRNA synthetase
HJ37_RS01290	COG2976	Protein conserved in bacteria
HJ37_RS01295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJ37_RS01300	COG1160	GTP binding
HJ37_RS01315	COG1570	exodeoxyribonuclease VII activity
HJ37_RS01320	COG0516	GMP reductase activity
HJ37_RS01320	COG0517	IMP dehydrogenase activity
HJ37_RS01325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HJ37_RS01325	COG0519	Catalyzes the synthesis of GMP from XMP
HJ37_RS01335	COG1584	GPR1 FUN34 yaaH family protein
HJ37_RS01340	COG3433	isochorismatase activity
HJ37_RS01340	COG1535	isochorismatase
HJ37_RS01345	COG1021	2,3-dihydroxybenzoate-AMP ligase
HJ37_RS01350	COG1169	isochorismate synthase
HJ37_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
HJ37_RS01365	COG4592	Periplasmic binding protein
HJ37_RS01370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJ37_RS01375	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJ37_RS01380	COG1120	ATPase activity
HJ37_RS01390	COG0583	DNA-binding transcription factor activity
HJ37_RS01395	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HJ37_RS01400	COG1115	amino acid carrier protein
HJ37_RS01410	COG0583	DNA-binding transcription factor activity
HJ37_RS01425	COG4565	transcriptional regulatory protein
HJ37_RS01435	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HJ37_RS01440	COG5016	pyruvate
HJ37_RS01440	COG0511	ligase activity, forming carbon-carbon bonds
HJ37_RS01445	COG3630	sodium ion export across plasma membrane
HJ37_RS01455	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HJ37_RS01465	COG2301	Belongs to the HpcH HpaI aldolase family
HJ37_RS01470	COG3051	citrate lyase alpha subunit
HJ37_RS01490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HJ37_RS01495	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HJ37_RS01500	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HJ37_RS01570	COG1012	belongs to the aldehyde dehydrogenase family
HJ37_RS01590	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HJ37_RS01595	COG0840	transmembrane signaling receptor activity
HJ37_RS01600	COG3710	Transcriptional regulator
HJ37_RS01610	COG2165	general secretion pathway protein
HJ37_RS01625	COG4796	Type ii and iii secretion system protein
HJ37_RS01645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HJ37_RS01650	COG1459	type II secretion system
HJ37_RS01660	COG2207	Transcriptional regulator
HJ37_RS01665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HJ37_RS01685	COG0739	heme binding
HJ37_RS01695	COG3064	Membrane
HJ37_RS01705	COG0582	viral genome integration into host DNA
HJ37_RS01710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HJ37_RS01715	COG2867	negative regulation of translational initiation
HJ37_RS01720	COG2914	Belongs to the UPF0125 (RnfH) family
HJ37_RS01725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJ37_RS01730	COG0497	DNA recombination
HJ37_RS01735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HJ37_RS01740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HJ37_RS01745	COG0443	Heat shock 70 kDa protein
HJ37_RS01750	COG0484	heat shock protein binding
HJ37_RS01785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HJ37_RS01800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HJ37_RS01810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HJ37_RS01810	COG0047	phosphoribosylformylglycinamidine synthase activity
HJ37_RS01840	COG0442	prolyl-tRNA aminoacylation
HJ37_RS01845	COG1720	tRNA m6t6A37 methyltransferase activity
HJ37_RS01850	COG0254	rRNA binding
HJ37_RS01855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HJ37_RS01860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HJ37_RS01865	COG1671	Belongs to the UPF0178 family
HJ37_RS01875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJ37_RS01890	COG3098	single-species biofilm formation
HJ37_RS01895	COG0564	pseudouridine synthase activity
HJ37_RS01900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HJ37_RS01905	COG0142	geranyltranstransferase activity
HJ37_RS01910	COG1722	exodeoxyribonuclease VII activity
HJ37_RS01915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HJ37_RS01925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HJ37_RS01925	COG0301	tRNA thio-modification
HJ37_RS01935	COG0583	DNA-binding transcription factor activity
HJ37_RS01940	COG2363	Small membrane protein
HJ37_RS01945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJ37_RS01950	COG1611	Belongs to the LOG family
HJ37_RS01965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HJ37_RS01965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HJ37_RS01975	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HJ37_RS01980	COG1464	Belongs to the NlpA lipoprotein family
HJ37_RS01985	COG2011	ABC-type metal ion transport system permease component
HJ37_RS01990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HJ37_RS01995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HJ37_RS02000	COG1609	Transcriptional regulator
HJ37_RS02005	COG1263	PTS System
HJ37_RS02005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HJ37_RS02010	COG0366	Alpha amylase catalytic
HJ37_RS02025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HJ37_RS02030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJ37_RS02035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HJ37_RS02040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HJ37_RS02045	COG0110	maltose O-acetyltransferase activity
HJ37_RS02065	COG1045	serine acetyltransferase
HJ37_RS02075	COG0438	transferase activity, transferring glycosyl groups
HJ37_RS02085	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HJ37_RS02115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HJ37_RS02125	COG1596	polysaccharide export
HJ37_RS02150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HJ37_RS02160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HJ37_RS02165	COG0321	lipoyl(octanoyl) transferase activity
HJ37_RS02170	COG2921	Belongs to the UPF0250 family
HJ37_RS02180	COG1686	Belongs to the peptidase S11 family
HJ37_RS02185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HJ37_RS02190	COG0772	Belongs to the SEDS family
HJ37_RS02195	COG0768	penicillin binding
HJ37_RS02200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HJ37_RS02205	COG0799	negative regulation of ribosome biogenesis
HJ37_RS02210	COG1466	dna polymerase III delta subunit
HJ37_RS02215	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HJ37_RS02220	COG0495	leucyl-tRNA aminoacylation
HJ37_RS02225	COG2888	peptidyl-tyrosine sulfation
HJ37_RS02230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HJ37_RS02235	COG4535	Mg2 and Co2 transporter CorC
HJ37_RS02245	COG1702	phosphate starvation-inducible protein PhoH
HJ37_RS02250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HJ37_RS02255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HJ37_RS02260	COG2190	(PTS) system
HJ37_RS02270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HJ37_RS02280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HJ37_RS02285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HJ37_RS02290	COG3115	cell septum assembly
HJ37_RS02295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HJ37_RS02310	COG0789	Transcriptional regulator
HJ37_RS02315	COG1585	Membrane protein implicated in regulation of membrane protease activity
HJ37_RS02320	COG0330	HflC and HflK could
HJ37_RS02325	COG3118	belongs to the thioredoxin family
HJ37_RS02330	COG0300	oxidoreductase activity
HJ37_RS02335	COG1090	epimerase
HJ37_RS02340	COG0622	Phosphoesterase
HJ37_RS02355	COG3710	Transcriptional regulator
HJ37_RS02360	COG0326	Molecular chaperone. Has ATPase activity
HJ37_RS02365	COG0563	adenylate kinase activity
HJ37_RS02370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HJ37_RS02385	COG0367	asparagine synthase
HJ37_RS02390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HJ37_RS02390	COG4651	solute:proton antiporter activity
HJ37_RS02395	COG1940	carbohydrate kinase activity
HJ37_RS02395	COG1846	Transcriptional regulator
HJ37_RS02400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HJ37_RS02405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HJ37_RS02405	COG2190	(PTS) system
HJ37_RS02405	COG1263	PTS System
HJ37_RS02420	COG0101	tRNA pseudouridine synthase activity
HJ37_RS02425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HJ37_RS02430	COG0285	dihydrofolate synthase activity
HJ37_RS02435	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HJ37_RS02440	COG1286	toxin biosynthetic process
HJ37_RS02445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HJ37_RS02450	COG2056	Na+-H+ antiporter family
HJ37_RS02455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HJ37_RS02475	COG0346	lactoylglutathione lyase activity
HJ37_RS02480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HJ37_RS02500	COG4656	Part of a membrane complex involved in electron transport
HJ37_RS02505	COG2878	Part of a membrane complex involved in electron transport
HJ37_RS02510	COG4657	Part of a membrane complex involved in electron transport
HJ37_RS02520	COG0556	nucleotide-excision repair
HJ37_RS02530	COG2204	response regulator
HJ37_RS02535	COG2198	Histidine kinase
HJ37_RS02540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HJ37_RS02545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HJ37_RS02550	COG0521	Mo-molybdopterin cofactor biosynthetic process
HJ37_RS02555	COG0315	cyclic pyranopterin monophosphate synthase activity
HJ37_RS02560	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HJ37_RS02565	COG0314	molybdopterin synthase activity
HJ37_RS02570	COG2199	diguanylate cyclase activity
HJ37_RS02575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HJ37_RS02575	COG0617	tRNA 3'-terminal CCA addition
HJ37_RS02575	COG0517	IMP dehydrogenase activity
HJ37_RS02590	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HJ37_RS02600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJ37_RS02600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJ37_RS02605	COG0489	protein tyrosine kinase activity
HJ37_RS02615	COG0572	uridine kinase
HJ37_RS02620	COG2982	Protein involved in outer membrane biogenesis
HJ37_RS02625	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HJ37_RS02630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJ37_RS02640	COG2067	long-chain fatty acid transport protein
HJ37_RS02660	COG0183	Belongs to the thiolase family
HJ37_RS02665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJ37_RS02665	COG1024	Enoyl-CoA hydratase
HJ37_RS02670	COG0778	Nitroreductase
HJ37_RS02675	COG0583	DNA-binding transcription factor activity
HJ37_RS02680	COG0745	RESPONSE REGULATOR receiver
HJ37_RS02690	COG2832	Protein of unknown function (DUF454)
HJ37_RS02695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HJ37_RS02705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HJ37_RS02710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HJ37_RS02720	COG2983	Belongs to the UPF0260 family
HJ37_RS02725	COG1028	Short-chain dehydrogenase reductase Sdr
HJ37_RS02730	COG0616	signal peptide processing
HJ37_RS02740	COG1522	sequence-specific DNA binding
HJ37_RS02745	COG1946	Acyl-CoA thioesterase
HJ37_RS02765	COG3706	GGDEF domain
HJ37_RS02770	COG0640	Transcriptional regulator
HJ37_RS02775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HJ37_RS02800	COG1881	PFAM PEBP family protein
HJ37_RS02820	COG0009	L-threonylcarbamoyladenylate synthase
HJ37_RS02835	COG2201	protein-glutamate methylesterase activity
HJ37_RS02845	COG5002	protein histidine kinase activity
HJ37_RS02850	COG4191	Histidine kinase
HJ37_RS02855	COG3300	MHYT domain
HJ37_RS02855	COG5001	Diguanylate cyclase
HJ37_RS02860	COG2204	response regulator
HJ37_RS02880	COG0601	transmembrane transport
HJ37_RS02885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJ37_RS02890	COG0444	Belongs to the ABC transporter superfamily
HJ37_RS02895	COG4608	Belongs to the ABC transporter superfamily
HJ37_RS02900	COG0435	Glutathione S-transferase
HJ37_RS02905	COG0280	phosphate acetyltransferase
HJ37_RS02905	COG0857	belongs to the CobB CobQ family
HJ37_RS02910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HJ37_RS02915	COG3092	negative regulation of chromosome organization
HJ37_RS02920	COG4628	conserved protein (DUF2132)
HJ37_RS02930	COG4120	Belongs to the binding-protein-dependent transport system permease family
HJ37_RS02940	COG2199	diguanylate cyclase activity
HJ37_RS02940	COG2203	Gaf domain
HJ37_RS02945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HJ37_RS02955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HJ37_RS02960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HJ37_RS02965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HJ37_RS02970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HJ37_RS02975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HJ37_RS02980	COG0156	8-amino-7-oxononanoate synthase activity
HJ37_RS02985	COG2226	methyltransferase
HJ37_RS02990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HJ37_RS03000	COG0501	Belongs to the peptidase M48B family
HJ37_RS03010	COG0300	oxidoreductase activity
HJ37_RS03025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HJ37_RS03035	COG2268	Band 7 protein
HJ37_RS03045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HJ37_RS03050	COG2915	High frequency lysogenization protein hflD homolog
HJ37_RS03055	COG0482	sulfurtransferase activity
HJ37_RS03060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HJ37_RS03065	COG2916	Histone family protein nucleoid-structuring protein H-NS
HJ37_RS03070	COG1757	Na H antiporter
HJ37_RS03075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HJ37_RS03080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HJ37_RS03085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HJ37_RS03090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HJ37_RS03090	COG0131	Imidazoleglycerol-phosphate dehydratase
HJ37_RS03095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HJ37_RS03100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HJ37_RS03105	COG0107	imidazoleglycerol-phosphate synthase activity
HJ37_RS03110	COG0140	phosphoribosyl-ATP diphosphatase activity
HJ37_RS03110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HJ37_RS03115	COG1187	pseudouridine synthase activity
HJ37_RS03125	COG1278	Cold shock
HJ37_RS03130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HJ37_RS03135	COG0542	response to heat
HJ37_RS03140	COG3273	potassium ion transport
HJ37_RS03140	COG2985	domain, Protein
HJ37_RS03145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HJ37_RS03150	COG1012	belongs to the aldehyde dehydrogenase family
HJ37_RS03150	COG1454	alcohol dehydrogenase
HJ37_RS03155	COG1737	Transcriptional regulator
HJ37_RS03160	COG0076	glutamate decarboxylase activity
HJ37_RS03170	COG2431	L-lysine efflux transmembrane transporter activity
HJ37_RS03180	COG3070	regulator of competence-specific genes
HJ37_RS03195	COG3852	Histidine kinase
HJ37_RS03205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HJ37_RS03225	COG0500	methyltransferase
HJ37_RS03230	COG4106	trans-aconitate 2-methyltransferase activity
HJ37_RS03235	COG1801	Protein of unknown function DUF72
HJ37_RS03240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HJ37_RS03245	COG1435	thymidine kinase activity
HJ37_RS03255	COG0159	tryptophan synthase activity
HJ37_RS03260	COG0133	tryptophan synthase activity
HJ37_RS03265	COG0135	phosphoribosylanthranilate isomerase activity
HJ37_RS03265	COG0134	indole-3-glycerol-phosphate synthase activity
HJ37_RS03270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HJ37_RS03275	COG0512	Glutamine amidotransferase of anthranilate synthase
HJ37_RS03280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HJ37_RS03290	COG0613	PHP domain protein
HJ37_RS03295	COG0009	L-threonylcarbamoyladenylate synthase
HJ37_RS03300	COG1187	pseudouridine synthase activity
HJ37_RS03305	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HJ37_RS03310	COG4988	ABC transporter
HJ37_RS03315	COG0492	ferredoxin-NADP+ reductase activity
HJ37_RS03325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HJ37_RS03330	COG3706	GGDEF domain
HJ37_RS03335	COG2949	membrane
HJ37_RS03345	COG0281	malic enzyme
HJ37_RS03355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HJ37_RS03375	COG2885	chlorophyll binding
HJ37_RS03390	COG0247	lactate metabolic process
HJ37_RS03390	COG0277	FAD linked oxidase domain protein
HJ37_RS03410	COG2986	histidine ammonia-lyase
HJ37_RS03415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HJ37_RS03420	COG0010	Belongs to the arginase family
HJ37_RS03425	COG1228	amidohydrolase
HJ37_RS03440	COG3099	Belongs to the UPF0263 family
HJ37_RS03445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HJ37_RS03455	COG5001	Diguanylate cyclase
HJ37_RS03460	COG0417	DNA replication proofreading
HJ37_RS03465	COG2197	response regulator
HJ37_RS03470	COG0322	excinuclease ABC activity
HJ37_RS03510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HJ37_RS03515	COG0072	phenylalanine-tRNA ligase activity
HJ37_RS03515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJ37_RS03520	COG0776	regulation of translation
HJ37_RS03560	COG1346	cytolysis
HJ37_RS03565	COG1380	Effector of murein hydrolase LrgA
HJ37_RS03570	COG2925	Exonuclease
HJ37_RS03575	COG1823	symporter activity
HJ37_RS03580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJ37_RS03585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HJ37_RS03590	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HJ37_RS03610	COG4139	cobalamin transport
HJ37_RS03660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HJ37_RS03665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HJ37_RS03670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HJ37_RS03680	COG1054	Belongs to the UPF0176 family
HJ37_RS03690	COG2814	Major facilitator Superfamily
HJ37_RS03700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJ37_RS03725	COG2989	Protein conserved in bacteria
HJ37_RS03730	COG3108	Peptidase M15
HJ37_RS03735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJ37_RS03750	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HJ37_RS03775	COG1846	Transcriptional regulator
HJ37_RS03780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HJ37_RS03785	COG0726	polysaccharide deacetylase
HJ37_RS03790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HJ37_RS03800	COG1447	Phosphotransferase system cellobiose-specific component IIA
HJ37_RS03805	COG1486	melibiose metabolic process
HJ37_RS03815	COG1609	Transcriptional regulator
HJ37_RS03820	COG2943	transferase activity, transferring hexosyl groups
HJ37_RS03825	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HJ37_RS03830	COG0840	transmembrane signaling receptor activity
HJ37_RS03845	COG1448	Aminotransferase
HJ37_RS03855	COG3437	response regulator, receiver
HJ37_RS03855	COG2770	Histidine kinase
HJ37_RS03860	COG0351	phosphomethylpyrimidine kinase
HJ37_RS03865	COG0017	Asparaginyl-tRNA synthetase
HJ37_RS03870	COG0840	transmembrane signaling receptor activity
HJ37_RS03875	COG0720	synthase
HJ37_RS03880	COG1760	l-serine dehydratase
HJ37_RS03885	COG0814	amino acid
HJ37_RS03890	COG0494	nUDIX hydrolase
HJ37_RS03895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HJ37_RS03910	COG3106	COG3106 Predicted ATPase
HJ37_RS03915	COG3768	UPF0283 membrane protein
HJ37_RS03925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HJ37_RS03940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HJ37_RS03950	COG0471	metal ion transport
HJ37_RS03955	COG4191	Histidine kinase
HJ37_RS03955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJ37_RS03965	COG2990	Protein conserved in bacteria
HJ37_RS03970	COG3713	MltA-interacting MipA family protein
HJ37_RS03975	COG2205	protein histidine kinase activity
HJ37_RS03980	COG0745	RESPONSE REGULATOR receiver
HJ37_RS04015	COG1129	ABC transporter
HJ37_RS04055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HJ37_RS04060	COG0372	Belongs to the citrate synthase family
HJ37_RS04090	COG2195	Cleaves the N-terminal amino acid of tripeptides
HJ37_RS04100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HJ37_RS04110	COG0625	glutathione transferase activity
HJ37_RS04115	COG3437	response regulator, receiver
HJ37_RS04135	COG3706	GGDEF domain
HJ37_RS04140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HJ37_RS04145	COG1254	Belongs to the acylphosphatase family
HJ37_RS04150	COG2920	part of a sulfur-relay system
HJ37_RS04155	COG0670	Belongs to the BI1 family
HJ37_RS04160	COG1126	abc transporter atp-binding protein
HJ37_RS04165	COG0765	amino acid transport
HJ37_RS04170	COG4597	amino acid ABC transporter
HJ37_RS04175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJ37_RS04185	COG0561	phosphatase activity
HJ37_RS04190	COG0602	queuosine metabolic process
HJ37_RS04195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HJ37_RS04225	COG3706	GGDEF domain
HJ37_RS04230	COG0443	Heat shock 70 kDa protein
HJ37_RS04235	COG0443	Heat shock 70 kDa protein
HJ37_RS04275	COG1643	Atp-dependent helicase
HJ37_RS04285	COG0443	Heat shock 70 kDa protein
HJ37_RS04290	COG0095	Lipoate-protein ligase
HJ37_RS04300	COG0583	DNA-binding transcription factor activity
HJ37_RS04305	COG0477	Major facilitator Superfamily
HJ37_RS04310	COG0415	Belongs to the DNA photolyase family
HJ37_RS04325	COG0745	RESPONSE REGULATOR receiver
HJ37_RS04335	COG0643	Histidine kinase
HJ37_RS04335	COG2198	Histidine kinase
HJ37_RS04340	COG0784	Response regulator, receiver
HJ37_RS04340	COG0643	Histidine kinase
HJ37_RS04340	COG2198	Histidine kinase
HJ37_RS04345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HJ37_RS04355	COG2201	protein-glutamate methylesterase activity
HJ37_RS04360	COG0835	chemotaxis
HJ37_RS04365	COG3290	protein histidine kinase activity
HJ37_RS04365	COG0840	transmembrane signaling receptor activity
HJ37_RS04370	COG0840	transmembrane signaling receptor activity
HJ37_RS04380	COG0513	Belongs to the DEAD box helicase family
HJ37_RS04390	COG1538	Outer membrane efflux protein
HJ37_RS04395	COG1566	PFAM secretion protein HlyD family protein
HJ37_RS04400	COG2814	Major facilitator Superfamily
HJ37_RS04410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HJ37_RS04420	COG3501	Rhs element vgr protein
HJ37_RS04430	COG3675	Pfam Lipase (class 3)
HJ37_RS04445	COG1280	lysine exporter protein (LysE YggA)
HJ37_RS04450	COG1115	amino acid carrier protein
HJ37_RS04465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HJ37_RS04475	COG1177	transmembrane transport
HJ37_RS04485	COG3842	ATPase activity
HJ37_RS04510	COG0589	response to stress
HJ37_RS04515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HJ37_RS04530	COG2217	Heavy metal translocating P-type atpase
HJ37_RS04540	COG2010	Cytochrome c
HJ37_RS04555	COG3278	Belongs to the heme-copper respiratory oxidase family
HJ37_RS04570	COG0784	Response regulator, receiver
HJ37_RS04570	COG2205	protein histidine kinase activity
HJ37_RS04595	COG2994	toxin metabolic process
HJ37_RS04600	COG3064	Membrane
HJ37_RS04600	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HJ37_RS04600	COG1073	alpha beta
HJ37_RS04615	COG4128	Pfam Zonular occludens toxin
HJ37_RS04645	COG1476	TRANSCRIPTIONal
HJ37_RS04665	COG1476	TRANSCRIPTIONal
HJ37_RS04710	COG3328	transposase activity
HJ37_RS04730	COG3120	sequence-specific DNA binding
HJ37_RS04735	COG1067	ATP-dependent peptidase activity
HJ37_RS04740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HJ37_RS04755	COG0488	(ABC) transporter
HJ37_RS04765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HJ37_RS04765	COG0116	Belongs to the methyltransferase superfamily
HJ37_RS04775	COG0167	dihydroorotate dehydrogenase activity
HJ37_RS04790	COG0308	aminopeptidase N
HJ37_RS04805	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HJ37_RS04810	COG1956	GAF domain-containing protein
HJ37_RS04815	COG1132	(ABC) transporter
HJ37_RS04820	COG2995	paraquat-inducible protein a
HJ37_RS04825	COG3008	intermembrane lipid transfer
HJ37_RS04835	COG2996	Protein conserved in bacteria
HJ37_RS04850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HJ37_RS04855	COG1666	GTP binding
HJ37_RS04860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HJ37_RS04875	COG0437	4 iron, 4 sulfur cluster binding
HJ37_RS04880	COG3383	formate dehydrogenase (NAD+) activity
HJ37_RS04880	COG0243	molybdopterin cofactor binding
HJ37_RS04910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HJ37_RS04915	COG0488	(ABC) transporter
HJ37_RS04920	COG3852	Histidine kinase
HJ37_RS04925	COG2204	response regulator
HJ37_RS04935	COG4662	Binding-protein-dependent transport system inner membrane component
HJ37_RS04940	COG3842	ATPase activity
HJ37_RS04945	COG0746	molybdenum cofactor guanylyltransferase activity
HJ37_RS04975	COG1940	carbohydrate kinase activity
HJ37_RS04980	COG3148	PFAM DTW domain containing protein
HJ37_RS04990	COG0840	transmembrane signaling receptor activity
HJ37_RS04995	COG0791	NLP P60 protein
HJ37_RS05005	COG3001	Fructosamine kinase
HJ37_RS05015	COG0534	Mate efflux family protein
HJ37_RS05025	COG1793	dna ligase
HJ37_RS05035	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HJ37_RS05040	COG0848	biopolymer transport protein
HJ37_RS05045	COG0811	peptide transport
HJ37_RS05065	COG1175	transmembrane transport
HJ37_RS05070	COG0395	ABC-type sugar transport system, permease component
HJ37_RS05075	COG3842	ATPase activity
HJ37_RS05080	COG1349	DNA-binding transcription factor activity
HJ37_RS05085	COG0584	glycerophosphoryl diester phosphodiesterase
HJ37_RS05090	COG2731	YhcH YjgK YiaL family protein
HJ37_RS05095	COG0251	oxidation-reduction process
HJ37_RS05100	COG1609	Transcriptional regulator
HJ37_RS05105	COG2723	6-phospho-beta-galactosidase activity
HJ37_RS05115	COG0583	DNA-binding transcription factor activity
HJ37_RS05135	COG1136	(ABC) transporter
HJ37_RS05135	COG0577	efflux transmembrane transporter activity
HJ37_RS05140	COG1136	(ABC) transporter
HJ37_RS05140	COG0577	efflux transmembrane transporter activity
HJ37_RS05145	COG4591	ABC-type transport system involved in lipoprotein release permease component
HJ37_RS05145	COG1136	(ABC) transporter
HJ37_RS05150	COG1294	oxidase, subunit
HJ37_RS05155	COG1271	oxidase subunit
HJ37_RS05195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJ37_RS05205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJ37_RS05225	COG0753	catalase activity
HJ37_RS05255	COG2200	EAL domain
HJ37_RS05255	COG2199	diguanylate cyclase activity
HJ37_RS05265	COG2017	converts alpha-aldose to the beta-anomer
HJ37_RS05270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HJ37_RS05275	COG1085	galactose-1-phosphate uridylyltransferase
HJ37_RS05315	COG0835	chemotaxis
HJ37_RS05315	COG0784	Response regulator, receiver
HJ37_RS05325	COG4565	transcriptional regulatory protein
HJ37_RS05330	COG3290	protein histidine kinase activity
HJ37_RS05345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HJ37_RS05365	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HJ37_RS05370	COG3063	Type IV pilus biogenesis stability protein PilW
HJ37_RS05380	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HJ37_RS05385	COG1451	nucleotide metabolic process
HJ37_RS05395	COG0583	DNA-binding transcription factor activity
HJ37_RS05415	COG1538	Outer membrane efflux protein
HJ37_RS05430	COG1748	Saccharopine dehydrogenase
HJ37_RS05440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJ37_RS05450	COG0577	efflux transmembrane transporter activity
HJ37_RS05455	COG4181	ATPase activity
HJ37_RS05460	COG0534	Mate efflux family protein
HJ37_RS05465	COG0702	epimerase
HJ37_RS05475	COG2814	Major facilitator Superfamily
HJ37_RS05480	COG1187	pseudouridine synthase activity
HJ37_RS05485	COG1061	Type III restriction enzyme res subunit
HJ37_RS05505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HJ37_RS05510	COG2203	Gaf domain
HJ37_RS05510	COG5001	Diguanylate cyclase
HJ37_RS05510	COG4251	negative regulation of phosphorylation
HJ37_RS05510	COG3706	GGDEF domain
HJ37_RS05525	COG0840	transmembrane signaling receptor activity
HJ37_RS05555	COG4934	collagen metabolic process
HJ37_RS05570	COG2205	protein histidine kinase activity
HJ37_RS05570	COG0784	Response regulator, receiver
HJ37_RS05575	COG2239	Acts as a magnesium transporter
HJ37_RS05585	COG0814	amino acid
HJ37_RS05590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HJ37_RS05595	COG1131	(ABC) transporter
HJ37_RS05600	COG0842	Transport permease protein
HJ37_RS05610	COG3313	Fe-S protein
HJ37_RS05620	COG4134	Bacterial extracellular solute-binding protein
HJ37_RS05625	COG4135	transport system, permease component
HJ37_RS05630	COG4136	ATPase activity
HJ37_RS05635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HJ37_RS05640	COG0564	pseudouridine synthase activity
HJ37_RS05645	COG0733	neurotransmitter:sodium symporter activity
HJ37_RS05655	COG0626	cystathionine gamma-synthase activity
HJ37_RS05660	COG2818	Glycosylase
HJ37_RS05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HJ37_RS05690	COG1842	Phage shock protein A
HJ37_RS05695	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HJ37_RS05705	COG4168	peptide transport system, permease
HJ37_RS05720	COG4172	Belongs to the ABC transporter superfamily
HJ37_RS05735	COG1227	inorganic diphosphatase activity
HJ37_RS05755	COG0243	molybdopterin cofactor binding
HJ37_RS05760	COG3005	denitrification pathway
HJ37_RS05765	COG4459	periplasmic nitrate reductase
HJ37_RS05775	COG2116	formate transmembrane transporter activity
HJ37_RS05785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJ37_RS05790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HJ37_RS05805	COG1607	acyl-coa hydrolase
HJ37_RS05810	COG2350	Protein conserved in bacteria
HJ37_RS05820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HJ37_RS05825	COG0583	DNA-binding transcription factor activity
HJ37_RS05840	COG0612	Peptidase, M16
HJ37_RS05845	COG5001	Diguanylate cyclase
HJ37_RS05850	COG1032	radical SAM domain protein
HJ37_RS05870	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HJ37_RS05880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HJ37_RS05885	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HJ37_RS05890	COG0745	RESPONSE REGULATOR receiver
HJ37_RS05895	COG3381	protein complex oligomerization
HJ37_RS05900	COG1609	Transcriptional regulator
HJ37_RS05905	COG3070	regulator of competence-specific genes
HJ37_RS05925	COG0297	glycogen (starch) synthase activity
HJ37_RS05930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HJ37_RS05935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HJ37_RS05965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HJ37_RS05970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HJ37_RS05995	COG1012	belongs to the aldehyde dehydrogenase family
HJ37_RS06000	COG1309	transcriptional regulator
HJ37_RS06025	COG0668	transmembrane transport
HJ37_RS06030	COG2995	paraquat-inducible protein a
HJ37_RS06035	COG3008	intermembrane lipid transfer
HJ37_RS06035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HJ37_RS06045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HJ37_RS06060	COG0582	viral genome integration into host DNA
HJ37_RS06070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HJ37_RS06090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HJ37_RS06110	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HJ37_RS06130	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HJ37_RS06135	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HJ37_RS06140	COG1737	Transcriptional regulator
HJ37_RS06145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJ37_RS06150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HJ37_RS06155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HJ37_RS06160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HJ37_RS06175	COG1940	carbohydrate kinase activity
HJ37_RS06180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HJ37_RS06185	COG4409	exo-alpha-(2->6)-sialidase activity
HJ37_RS06195	COG2003	Belongs to the UPF0758 family
HJ37_RS06215	COG3941	tape measure
HJ37_RS06255	COG0488	(ABC) transporter
HJ37_RS06330	COG0415	Belongs to the DNA photolyase family
HJ37_RS06340	COG4628	conserved protein (DUF2132)
HJ37_RS06345	COG3284	Transcriptional regulator
HJ37_RS06350	COG1012	belongs to the aldehyde dehydrogenase family
HJ37_RS06360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HJ37_RS06365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HJ37_RS06370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HJ37_RS06380	COG2207	Transcriptional regulator
HJ37_RS06385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HJ37_RS06385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HJ37_RS06385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HJ37_RS06390	COG1482	cell wall glycoprotein biosynthetic process
HJ37_RS06400	COG0784	Response regulator, receiver
HJ37_RS06400	COG5002	protein histidine kinase activity
HJ37_RS06410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HJ37_RS06420	COG2885	chlorophyll binding
HJ37_RS06425	COG0823	Involved in the tonB-independent uptake of proteins
HJ37_RS06440	COG0811	peptide transport
HJ37_RS06445	COG0824	Thioesterase
HJ37_RS06450	COG3790	cyd operon protein YbgE
HJ37_RS06455	COG4890	Cyd operon protein YbgT
HJ37_RS06460	COG1294	oxidase, subunit
HJ37_RS06465	COG1271	oxidase subunit
HJ37_RS06475	COG0632	four-way junction helicase activity
HJ37_RS06480	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HJ37_RS06485	COG0215	cysteine-tRNA ligase activity
HJ37_RS06490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HJ37_RS06495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HJ37_RS06500	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HJ37_RS06505	COG3012	SEC-C Motif Domain Protein
HJ37_RS06510	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HJ37_RS06515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HJ37_RS06520	COG1199	ATP-dependent helicase activity
HJ37_RS06525	COG0730	response to heat
HJ37_RS06530	COG3923	Primosomal replication protein n
HJ37_RS06540	COG0840	transmembrane signaling receptor activity
HJ37_RS06545	COG0708	Exodeoxyribonuclease III
HJ37_RS06550	COG4160	amino acid transport
HJ37_RS06575	COG1882	Formate acetyltransferase
HJ37_RS06585	COG0840	transmembrane signaling receptor activity
HJ37_RS06590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HJ37_RS06600	COG3013	Belongs to the UPF0304 family
HJ37_RS06605	COG2766	serine protein kinase
HJ37_RS06610	COG2718	Belongs to the UPF0229 family
HJ37_RS06615	COG2719	SpoVR family
HJ37_RS06620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HJ37_RS06625	COG2835	tetraacyldisaccharide 4'-kinase activity
HJ37_RS06630	COG1663	tetraacyldisaccharide 4'-kinase activity
HJ37_RS06635	COG1132	(ABC) transporter
HJ37_RS06640	COG0658	competence protein
HJ37_RS06640	COG2333	competence protein COMEC
HJ37_RS06650	COG4591	ABC-type transport system involved in lipoprotein release permease component
HJ37_RS06655	COG1136	(ABC) transporter
HJ37_RS06660	COG4591	ABC-type transport system involved in lipoprotein release permease component
HJ37_RS06670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HJ37_RS06690	COG1252	NADH dehydrogenase
HJ37_RS06695	COG3150	esterase
HJ37_RS06720	COG0537	adenosine 5'-monophosphoramidase activity
HJ37_RS06735	COG2186	Transcriptional regulator
HJ37_RS06740	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJ37_RS06745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HJ37_RS06750	COG1674	ftsk spoiiie
HJ37_RS06760	COG0686	Belongs to the AlaDH PNT family
HJ37_RS06770	COG0583	DNA-binding transcription factor activity
HJ37_RS06790	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HJ37_RS06795	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HJ37_RS06800	COG0776	regulation of translation
HJ37_RS06805	COG0539	negative regulation of cytoplasmic translation
HJ37_RS06810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HJ37_RS06815	COG1555	photosystem II stabilization
HJ37_RS06820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HJ37_RS06825	COG0776	regulation of translation
HJ37_RS06830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HJ37_RS06835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HJ37_RS06845	COG0544	peptidyl-prolyl cis-trans isomerase activity
HJ37_RS06855	COG4191	Histidine kinase
HJ37_RS06865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HJ37_RS06870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HJ37_RS06875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HJ37_RS06880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HJ37_RS06895	COG5001	Diguanylate cyclase
HJ37_RS06895	COG3300	MHYT domain
HJ37_RS06905	COG4589	Belongs to the CDS family
HJ37_RS06940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HJ37_RS06950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HJ37_RS06965	COG0243	molybdopterin cofactor binding
HJ37_RS06970	COG3005	denitrification pathway
HJ37_RS06975	COG3325	Belongs to the glycosyl hydrolase 18 family
HJ37_RS06975	COG3469	chitinase activity
HJ37_RS06980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HJ37_RS06990	COG2951	lytic endotransglycosylase activity
HJ37_RS06995	COG3100	YcgL domain-containing protein
HJ37_RS07000	COG0850	regulation of cytokinetic process
HJ37_RS07005	COG2894	cell division
HJ37_RS07010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HJ37_RS07015	COG3015	lipoprotein NlpE involved in copper resistance
HJ37_RS07035	COG0477	Major facilitator Superfamily
HJ37_RS07045	COG0840	transmembrane signaling receptor activity
HJ37_RS07050	COG1396	sequence-specific DNA binding
HJ37_RS07055	COG3135	benzoate transporter
HJ37_RS07075	COG0596	Alpha beta hydrolase
HJ37_RS07080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HJ37_RS07085	COG1169	isochorismate synthase
HJ37_RS07090	COG0436	Aminotransferase
HJ37_RS07095	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HJ37_RS07100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HJ37_RS07120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HJ37_RS07125	COG0318	PFAM AMP-dependent synthetase and ligase
HJ37_RS07130	COG0596	Alpha beta hydrolase
HJ37_RS07145	COG1214	PFAM Peptidase M22, glycoprotease
HJ37_RS07150	COG1199	ATP-dependent helicase activity
HJ37_RS07160	COG0788	formyltetrahydrofolate deformylase activity
HJ37_RS07165	COG1902	pentaerythritol trinitrate reductase activity
HJ37_RS07165	COG0446	pyridine nucleotide-disulphide oxidoreductase
HJ37_RS07170	COG0616	signal peptide processing
HJ37_RS07175	COG0252	asparaginase activity
HJ37_RS07180	COG3139	Protein of unknown function (DUF1315)
HJ37_RS07190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJ37_RS07195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HJ37_RS07200	COG0676	glucose-6-phosphate 1-epimerase activity
HJ37_RS07210	COG2226	methyltransferase
HJ37_RS07225	COG0835	chemotaxis
HJ37_RS07225	COG0784	Response regulator, receiver
HJ37_RS07230	COG1940	carbohydrate kinase activity
HJ37_RS07240	COG4667	esterase of the alpha-beta hydrolase superfamily
HJ37_RS07255	COG0733	neurotransmitter:sodium symporter activity
HJ37_RS07260	COG1263	PTS System
HJ37_RS07260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HJ37_RS07265	COG0084	hydrolase, TatD family'
HJ37_RS07275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HJ37_RS07280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HJ37_RS07285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HJ37_RS07290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HJ37_RS07295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HJ37_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
HJ37_RS07310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HJ37_RS07315	COG0416	fatty acid biosynthetic process
HJ37_RS07320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HJ37_RS07325	COG1399	metal-binding, possibly nucleic acid-binding protein
HJ37_RS07330	COG0424	maF-like protein
HJ37_RS07335	COG0564	pseudouridine synthase activity
HJ37_RS07350	COG1530	ribonuclease E activity
HJ37_RS07355	COG0659	secondary active sulfate transmembrane transporter activity
HJ37_RS07365	COG1012	belongs to the aldehyde dehydrogenase family
HJ37_RS07365	COG1454	alcohol dehydrogenase
HJ37_RS07370	COG2095	MarC family integral membrane protein
HJ37_RS07375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HJ37_RS07380	COG1757	Na H antiporter
HJ37_RS07390	COG3081	Nucleoid-associated protein
HJ37_RS07395	COG3082	Protein of unknown function (DUF1414)
HJ37_RS07400	COG3083	sulfuric ester hydrolase activity
HJ37_RS07415	COG0123	including yeast histone deacetylase and acetoin utilization protein
HJ37_RS07420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HJ37_RS07425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HJ37_RS07445	COG2853	Lipoprotein
HJ37_RS07455	COG4235	cytochrome complex assembly
HJ37_RS07455	COG3088	subunit of a heme lyase
HJ37_RS07460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJ37_RS07465	COG1138	Cytochrome C-type biogenesis protein
HJ37_RS07470	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HJ37_RS07480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HJ37_RS07485	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HJ37_RS07490	COG4133	protoheme IX ABC transporter activity
HJ37_RS07500	COG0835	chemotaxis
HJ37_RS07510	COG1192	Involved in chromosome partitioning
HJ37_RS07515	COG2201	protein-glutamate methylesterase activity
HJ37_RS07520	COG2198	Histidine kinase
HJ37_RS07520	COG0643	Histidine kinase
HJ37_RS07520	COG0784	Response regulator, receiver
HJ37_RS07525	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HJ37_RS07555	COG2062	phosphohistidine phosphatase, SixA
HJ37_RS07560	COG1025	Belongs to the peptidase M16 family
HJ37_RS07570	COG0018	arginyl-trna synthetase
HJ37_RS07590	COG1918	ferrous iron import across plasma membrane
HJ37_RS07595	COG4977	sequence-specific DNA binding
HJ37_RS07600	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HJ37_RS07605	COG1121	(ABC) transporter
HJ37_RS07610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HJ37_RS07620	COG0045	succinate-CoA ligase (ADP-forming) activity
HJ37_RS07625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJ37_RS07630	COG0567	Dehydrogenase, E1 component
HJ37_RS07640	COG1053	succinate dehydrogenase
HJ37_RS07645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HJ37_RS07650	COG2009	succinate dehydrogenase
HJ37_RS07655	COG0372	Belongs to the citrate synthase family
HJ37_RS07660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HJ37_RS07670	COG0033	Phosphoglucomutase
HJ37_RS07675	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HJ37_RS07680	COG0596	Alpha beta hydrolase
HJ37_RS07695	COG1346	cytolysis
HJ37_RS07705	COG0583	DNA-binding transcription factor activity
HJ37_RS07715	COG0735	belongs to the Fur family
HJ37_RS07720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HJ37_RS07725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HJ37_RS07730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HJ37_RS07740	COG0431	NADPH-dependent FMN reductase
HJ37_RS07750	COG3101	peptidyl-lysine hydroxylation
HJ37_RS07755	COG2860	membrane
HJ37_RS07760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HJ37_RS07770	COG2890	protein-(glutamine-N5) methyltransferase activity
HJ37_RS07775	COG2840	Smr protein MutS2
HJ37_RS07785	COG1684	flagellar biosynthetic protein fliR
HJ37_RS07790	COG1987	bacterial-type flagellum assembly
HJ37_RS07815	COG1580	Controls the rotational direction of flagella during chemotaxis
HJ37_RS07835	COG1317	bacterial-type flagellum organization
HJ37_RS07840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HJ37_RS07850	COG1677	Flagellar hook-basal body complex protein FliE
HJ37_RS07870	COG1516	flagellar protein fliS
HJ37_RS07880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HJ37_RS07885	COG1334	flagellar protein FlaG
HJ37_RS07890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HJ37_RS07895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HJ37_RS07900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HJ37_RS07905	COG2837	iron assimilation
HJ37_RS07925	COG1393	Belongs to the ArsC family
HJ37_RS07935	COG1876	peptidase activity
HJ37_RS07945	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HJ37_RS07960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HJ37_RS07980	COG4783	chaperone-mediated protein folding
HJ37_RS07985	COG1393	Belongs to the ArsC family
HJ37_RS08005	COG2233	PERMEase
HJ37_RS08010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HJ37_RS08015	COG0737	Belongs to the 5'-nucleotidase family
HJ37_RS08020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HJ37_RS08025	COG2912	Transglutaminase-like superfamily
HJ37_RS08035	COG2890	protein-(glutamine-N5) methyltransferase activity
HJ37_RS08040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HJ37_RS08045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HJ37_RS08050	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HJ37_RS08055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HJ37_RS08060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HJ37_RS08065	COG0193	aminoacyl-tRNA hydrolase activity
HJ37_RS08070	COG0012	GTP binding
HJ37_RS08100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HJ37_RS08105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HJ37_RS08125	COG3951	Flagellar rod assembly protein muramidase FlgJ
HJ37_RS08125	COG1705	Flagellar rod assembly protein muramidase FlgJ
HJ37_RS08130	COG1706	bacterial-type flagellum-dependent cell motility
HJ37_RS08135	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HJ37_RS08145	COG4787	bacterial-type flagellum-dependent cell motility
HJ37_RS08150	COG1749	Flagellar hook protein flgE
HJ37_RS08165	COG1815	bacterial-type flagellum-dependent cell motility
HJ37_RS08170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HJ37_RS08175	COG0835	chemotaxis
HJ37_RS08175	COG0784	Response regulator, receiver
HJ37_RS08210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJ37_RS08210	COG3433	isochorismatase activity
HJ37_RS08210	COG2226	methyltransferase
HJ37_RS08215	COG2375	cellular response to nickel ion
HJ37_RS08220	COG4774	siderophore transport
HJ37_RS08220	COG1629	transport
HJ37_RS08235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJ37_RS08240	COG2608	mercury ion transmembrane transporter activity
HJ37_RS08240	COG2217	Heavy metal translocating P-type atpase
HJ37_RS08255	COG3735	TraB family
HJ37_RS08270	COG2840	Smr protein MutS2
HJ37_RS08275	COG1187	pseudouridine synthase activity
HJ37_RS08285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HJ37_RS08290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HJ37_RS08295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HJ37_RS08300	COG0121	glutamine amidotransferase
HJ37_RS08305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HJ37_RS08310	COG1960	acyl-CoA dehydrogenase activity
HJ37_RS08325	COG0328	RNA-DNA hybrid ribonuclease activity
HJ37_RS08330	COG2226	methyltransferase
HJ37_RS08335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJ37_RS08340	COG0741	lytic transglycosylase activity
HJ37_RS08340	COG1388	LysM domain
HJ37_RS08345	COG3021	interspecies interaction between organisms
HJ37_RS08350	COG0347	Belongs to the P(II) protein family
HJ37_RS08355	COG3479	Phenolic acid decarboxylase
HJ37_RS08365	COG0037	tRNA processing
HJ37_RS08370	COG0825	malonyl-CoA metabolic process
HJ37_RS08375	COG0587	DNA-directed DNA polymerase activity
HJ37_RS08380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HJ37_RS08385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HJ37_RS08390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HJ37_RS08395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HJ37_RS08400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HJ37_RS08405	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HJ37_RS08415	COG0750	zinc metalloprotease
HJ37_RS08420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HJ37_RS08425	COG0575	Belongs to the CDS family
HJ37_RS08430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HJ37_RS08435	COG0233	cytoplasmic translational termination
HJ37_RS08440	COG0528	UMP kinase activity
HJ37_RS08445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HJ37_RS08450	COG0052	Belongs to the universal ribosomal protein uS2 family
HJ37_RS08455	COG0024	Methionine aminopeptidase
HJ37_RS08460	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HJ37_RS08470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HJ37_RS08475	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HJ37_RS08480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HJ37_RS08485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HJ37_RS08500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HJ37_RS08500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HJ37_RS08505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HJ37_RS08510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HJ37_RS08515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HJ37_RS08525	COG1073	alpha beta
HJ37_RS08530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HJ37_RS08535	COG2252	PERMEase
HJ37_RS08540	COG2195	Cleaves the N-terminal amino acid of tripeptides
HJ37_RS08545	COG4067	protein conserved in archaea
HJ37_RS08545	COG0189	ligase activity
HJ37_RS08550	COG0189	ligase activity
HJ37_RS08560	COG0733	neurotransmitter:sodium symporter activity
HJ37_RS08565	COG3706	GGDEF domain
HJ37_RS08590	COG1477	protein flavinylation
HJ37_RS08595	COG2871	sodium ion transport
HJ37_RS08600	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HJ37_RS08605	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HJ37_RS08610	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HJ37_RS08615	COG1805	sodium ion transport
HJ37_RS08620	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HJ37_RS08625	COG0271	Belongs to the BolA IbaG family
HJ37_RS08630	COG2813	Specifically methylates the guanine in position
HJ37_RS08640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HJ37_RS08645	COG2211	Major facilitator Superfamily
HJ37_RS08655	COG1595	DNA-templated transcription, initiation
HJ37_RS08665	COG3248	Nucleoside-binding outer membrane protein
HJ37_RS08670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HJ37_RS08675	COG0693	protein deglycase activity
HJ37_RS08680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HJ37_RS08685	COG2166	iron-sulfur cluster assembly
HJ37_RS08690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HJ37_RS08695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HJ37_RS08705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HJ37_RS08705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HJ37_RS08720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HJ37_RS08725	COG1074	ATP-dependent DNA helicase activity
HJ37_RS08730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HJ37_RS08745	COG3141	response to X-ray
HJ37_RS08750	COG2171	N-acyltransferase activity
HJ37_RS08760	COG0456	acetyltransferase
HJ37_RS08765	COG0569	domain protein
HJ37_RS08765	COG0189	ligase activity
HJ37_RS08780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJ37_RS08785	COG1609	Transcriptional regulator
HJ37_RS08790	COG3250	beta-galactosidase activity
HJ37_RS08805	COG1022	Amp-dependent synthetase and ligase
HJ37_RS08810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HJ37_RS08815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HJ37_RS08825	COG0560	Phosphoserine phosphatase
HJ37_RS08835	COG0813	purine-nucleoside phosphorylase activity
HJ37_RS08840	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HJ37_RS08845	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HJ37_RS08850	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HJ37_RS08860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HJ37_RS08865	COG0084	hydrolase, TatD family'
HJ37_RS08870	COG3022	response to hydroperoxide
HJ37_RS08875	COG1115	amino acid carrier protein
HJ37_RS08890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HJ37_RS08895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HJ37_RS08900	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HJ37_RS08905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HJ37_RS08925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HJ37_RS08935	COG0745	RESPONSE REGULATOR receiver
HJ37_RS08940	COG0784	Response regulator, receiver
HJ37_RS08940	COG2198	Histidine kinase
HJ37_RS08940	COG5002	protein histidine kinase activity
HJ37_RS08945	COG5001	Diguanylate cyclase
HJ37_RS08945	COG4251	negative regulation of phosphorylation
HJ37_RS08945	COG3706	GGDEF domain
HJ37_RS08945	COG2203	Gaf domain
HJ37_RS08950	COG1242	4 iron, 4 sulfur cluster binding
HJ37_RS08955	COG0070	glutamate synthase
HJ37_RS08955	COG0069	glutamate synthase activity
HJ37_RS08955	COG0067	glutamate synthase
HJ37_RS08965	COG0069	glutamate synthase activity
HJ37_RS08965	COG0070	glutamate synthase
HJ37_RS08965	COG0067	glutamate synthase
HJ37_RS08970	COG0493	'glutamate synthase
HJ37_RS08980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HJ37_RS08990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HJ37_RS08995	COG2860	membrane
HJ37_RS09000	COG0583	DNA-binding transcription factor activity
HJ37_RS09005	COG0730	response to heat
HJ37_RS09015	COG4172	Belongs to the ABC transporter superfamily
HJ37_RS09035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HJ37_RS09040	COG0505	Belongs to the CarA family
HJ37_RS09050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HJ37_RS09055	COG0494	nUDIX hydrolase
HJ37_RS09065	COG0653	protein targeting
HJ37_RS09075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HJ37_RS09080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HJ37_RS09085	COG0849	cell division
HJ37_RS09090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HJ37_RS09095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HJ37_RS09105	COG0772	Belongs to the SEDS family
HJ37_RS09110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HJ37_RS09120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HJ37_RS09125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HJ37_RS09130	COG0768	penicillin binding
HJ37_RS09135	COG3116	cell division
HJ37_RS09145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJ37_RS09150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJ37_RS09155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HJ37_RS09160	COG2186	Transcriptional regulator
HJ37_RS09165	COG0737	Belongs to the 5'-nucleotidase family
HJ37_RS09170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HJ37_RS09175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HJ37_RS09180	COG4974	Belongs to the 'phage' integrase family
HJ37_RS09185	COG0716	FMN binding
HJ37_RS09205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HJ37_RS09210	COG1459	type II secretion system
HJ37_RS09220	COG0237	dephospho-CoA kinase activity
HJ37_RS09225	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HJ37_RS09235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HJ37_RS09240	COG0187	DNA topoisomerase II activity
HJ37_RS09245	COG3150	esterase
HJ37_RS09255	COG3151	Protein conserved in bacteria
HJ37_RS09260	COG0494	nUDIX hydrolase
HJ37_RS09265	COG1538	Outer membrane efflux protein
HJ37_RS09275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HJ37_RS09280	COG0840	transmembrane signaling receptor activity
HJ37_RS09285	COG3025	triphosphatase activity
HJ37_RS09290	COG1392	Phosphate transport regulator
HJ37_RS09295	COG0306	phosphate transporter
HJ37_RS09300	COG4991	sh3 domain protein
HJ37_RS09310	COG3409	Peptidoglycan-binding domain 1 protein
HJ37_RS09310	COG3267	Type II secretory pathway component ExeA
HJ37_RS09320	COG0148	phosphopyruvate hydratase activity
HJ37_RS09325	COG0504	CTP synthase activity
HJ37_RS09330	COG3956	TIGRFAM MazG family protein
HJ37_RS09335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HJ37_RS09350	COG5001	Diguanylate cyclase
HJ37_RS09370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HJ37_RS09375	COG1381	Involved in DNA repair and RecF pathway recombination
HJ37_RS09380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HJ37_RS09395	COG0481	GTPase activity
HJ37_RS09400	COG3086	response to oxidative stress
HJ37_RS09415	COG1595	DNA-templated transcription, initiation
HJ37_RS09425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HJ37_RS09435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HJ37_RS09450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HJ37_RS09455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HJ37_RS09460	COG3079	Belongs to the UPF0149 family
HJ37_RS09465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HJ37_RS09470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HJ37_RS09475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HJ37_RS09480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HJ37_RS09485	COG0440	acetolactate synthase activity
HJ37_RS09490	COG0028	Belongs to the TPP enzyme family
HJ37_RS09495	COG1022	Amp-dependent synthetase and ligase
HJ37_RS09500	COG0583	DNA-binding transcription factor activity
HJ37_RS09525	COG0473	3-isopropylmalate dehydrogenase activity
HJ37_RS09530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HJ37_RS09535	COG0066	3-isopropylmalate dehydratase activity
HJ37_RS09580	COG3437	response regulator, receiver
HJ37_RS09595	COG0795	lipopolysaccharide-transporting ATPase activity
HJ37_RS09600	COG0795	lipopolysaccharide-transporting ATPase activity
HJ37_RS09605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HJ37_RS09610	COG2927	DNA polymerase III (CHI subunit)
HJ37_RS09615	COG0525	valine-tRNA ligase activity
HJ37_RS09620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HJ37_RS09625	COG0564	pseudouridine synthase activity
HJ37_RS09640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HJ37_RS09655	COG0540	Belongs to the ATCase OTCase family
HJ37_RS09665	COG0251	oxidation-reduction process
HJ37_RS09675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HJ37_RS09680	COG5007	Belongs to the BolA IbaG family
HJ37_RS09690	COG2854	intermembrane phospholipid transfer
HJ37_RS09695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HJ37_RS09700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HJ37_RS09705	COG1127	ABC transporter
HJ37_RS09720	COG0517	IMP dehydrogenase activity
HJ37_RS09720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HJ37_RS09735	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HJ37_RS09740	COG1137	ATPase activity
HJ37_RS09750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HJ37_RS09755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HJ37_RS09760	COG1660	Displays ATPase and GTPase activities
HJ37_RS09765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HJ37_RS09770	COG2239	Acts as a magnesium transporter
HJ37_RS09775	COG0312	modulator of DNA gyrase
HJ37_RS09780	COG3028	Belongs to the UPF0307 family
HJ37_RS09785	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HJ37_RS09790	COG1178	ABC-type Fe3 transport system permease component
HJ37_RS09800	COG0163	prenyltransferase activity
HJ37_RS09805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HJ37_RS09820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HJ37_RS09825	COG2105	PFAM AIG2 family protein
HJ37_RS09835	COG0729	surface antigen
HJ37_RS09840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJ37_RS09845	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HJ37_RS09860	COG1136	(ABC) transporter
HJ37_RS09880	COG0529	Catalyzes the synthesis of activated sulfate
HJ37_RS09895	COG1648	precorrin-2 dehydrogenase activity
HJ37_RS09895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HJ37_RS09900	COG0737	Belongs to the 5'-nucleotidase family
HJ37_RS09910	COG0513	Belongs to the DEAD box helicase family
HJ37_RS09915	COG2153	protein acetylation
HJ37_RS09920	COG0697	spore germination
HJ37_RS09925	COG3266	domain, Protein
HJ37_RS09925	COG3061	Opacity-associated protein A
HJ37_RS09930	COG0545	Peptidyl-prolyl cis-trans isomerase
HJ37_RS09940	COG0203	ribosomal protein L17
HJ37_RS09945	COG0202	RNA polymerase activity
HJ37_RS09950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HJ37_RS09955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HJ37_RS09960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HJ37_RS09965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HJ37_RS09970	COG0201	protein transport
HJ37_RS09980	COG1841	ribosomal large subunit assembly
HJ37_RS09985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HJ37_RS09990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HJ37_RS10000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HJ37_RS10005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HJ37_RS10010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HJ37_RS10015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HJ37_RS10020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HJ37_RS10025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HJ37_RS10030	COG0255	Belongs to the universal ribosomal protein uL29 family
HJ37_RS10035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HJ37_RS10040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HJ37_RS10045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HJ37_RS10050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HJ37_RS10055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HJ37_RS10060	COG0089	rRNA binding
HJ37_RS10065	COG0088	Forms part of the polypeptide exit tunnel
HJ37_RS10070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HJ37_RS10075	COG0051	transcription antitermination factor activity, RNA binding
HJ37_RS10080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HJ37_RS10085	COG0557	exoribonuclease II activity
HJ37_RS10090	COG3083	sulfuric ester hydrolase activity
HJ37_RS10095	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HJ37_RS10110	COG1047	Peptidyl-prolyl cis-trans
HJ37_RS10125	COG2249	NAD(P)H dehydrogenase (quinone) activity
HJ37_RS10130	COG0488	(ABC) transporter
HJ37_RS10140	COG0429	hydrolase of the alpha beta-hydrolase fold
HJ37_RS10150	COG3954	Phosphoribulokinase
HJ37_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
HJ37_RS10175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HJ37_RS10185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HJ37_RS10200	COG0180	Tryptophanyl-tRNA synthetase
HJ37_RS10205	COG0546	phosphoglycolate phosphatase activity
HJ37_RS10210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HJ37_RS10215	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HJ37_RS10225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HJ37_RS10230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HJ37_RS10260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HJ37_RS10270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HJ37_RS10270	COG0678	peroxiredoxin activity
HJ37_RS10275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJ37_RS10285	COG0165	Argininosuccinate lyase
HJ37_RS10290	COG0137	argininosuccinate synthase activity
HJ37_RS10295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HJ37_RS10300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HJ37_RS10305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJ37_RS10310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HJ37_RS10320	COG1045	serine acetyltransferase
HJ37_RS10325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HJ37_RS10330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HJ37_RS10335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HJ37_RS10340	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HJ37_RS10345	COG1053	succinate dehydrogenase
HJ37_RS10350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HJ37_RS10355	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HJ37_RS10365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HJ37_RS10370	COG1509	lysine 2,3-aminomutase activity
HJ37_RS10380	COG0459	protein refolding
HJ37_RS10385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HJ37_RS10410	COG0149	triose-phosphate isomerase activity
HJ37_RS10415	COG0534	Mate efflux family protein
HJ37_RS10420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HJ37_RS10425	COG1575	Belongs to the MenA family. Type 1 subfamily
HJ37_RS10430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HJ37_RS10435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HJ37_RS10440	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HJ37_RS10445	COG1609	Transcriptional regulator
HJ37_RS10450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HJ37_RS10455	COG0254	rRNA binding
HJ37_RS10460	COG0281	malic enzyme
HJ37_RS10465	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HJ37_RS10470	COG0626	cystathionine gamma-synthase activity
HJ37_RS10475	COG0460	homoserine dehydrogenase
HJ37_RS10475	COG0527	aspartate kinase activity
HJ37_RS10480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HJ37_RS10485	COG3074	FtsZ-dependent cytokinesis
HJ37_RS10490	COG1494	fructose-1,6-bisphosphatase
HJ37_RS10495	COG0205	6-phosphofructokinase activity
HJ37_RS10500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HJ37_RS10510	COG0745	RESPONSE REGULATOR receiver
HJ37_RS10515	COG2205	protein histidine kinase activity
HJ37_RS10525	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HJ37_RS10530	COG3030	protein affecting phage T7 exclusion by the F plasmid
HJ37_RS10535	COG3706	GGDEF domain
HJ37_RS10540	COG1027	Aspartate ammonia-lyase
HJ37_RS10545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HJ37_RS10560	COG4232	protein-disulfide reductase activity
HJ37_RS10580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJ37_RS10585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HJ37_RS10590	COG0194	GDP metabolic process
HJ37_RS10595	COG1758	RNA polymerase activity
HJ37_RS10600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HJ37_RS10605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HJ37_RS10610	COG2233	PERMEase
HJ37_RS10625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HJ37_RS10630	COG2183	response to ionizing radiation
HJ37_RS10640	COG0596	Alpha beta hydrolase
HJ37_RS10645	COG1040	competence protein
HJ37_RS10655	COG0494	nUDIX hydrolase
HJ37_RS10660	COG1218	3'(2'),5'-bisphosphate nucleotidase
HJ37_RS10670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HJ37_RS10675	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HJ37_RS10680	COG3156	type II secretion system protein K
HJ37_RS10685	COG4795	General secretion pathway protein
HJ37_RS10690	COG2165	general secretion pathway protein
HJ37_RS10695	COG2165	general secretion pathway protein
HJ37_RS10700	COG2165	general secretion pathway protein
HJ37_RS10705	COG1459	type II secretion system
HJ37_RS10710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HJ37_RS10720	COG3031	protein transport across the cell outer membrane
HJ37_RS10725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HJ37_RS10730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HJ37_RS10735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HJ37_RS10745	COG0456	acetyltransferase
HJ37_RS10750	COG1490	D-aminoacyl-tRNA deacylase activity
HJ37_RS10755	COG1295	ribonuclease BN
HJ37_RS10765	COG1217	gtp-binding protein TYPA
HJ37_RS10775	COG0174	glutamine synthetase
HJ37_RS10785	COG3852	Histidine kinase
HJ37_RS10795	COG5001	Diguanylate cyclase
HJ37_RS10795	COG3300	MHYT domain
HJ37_RS10800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HJ37_RS10835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HJ37_RS10840	COG1404	Belongs to the peptidase S8 family
HJ37_RS10845	COG4206	TonB-dependent receptor
HJ37_RS10850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HJ37_RS10865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJ37_RS10870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJ37_RS10875	COG2177	Part of the ABC transporter FtsEX involved in
HJ37_RS10880	COG2884	Cell division ATP-binding protein ftsE
HJ37_RS10885	COG0552	protein localization to endoplasmic reticulum
HJ37_RS10890	COG0742	ribosomal rna small subunit methyltransferase
HJ37_RS10925	COG0783	Belongs to the Dps family
HJ37_RS10930	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HJ37_RS10935	COG1280	lysine exporter protein (LysE YggA)
HJ37_RS10940	COG2267	carboxylic ester hydrolase activity
HJ37_RS10945	COG0561	phosphatase activity
HJ37_RS10965	COG3287	FIST C domain
HJ37_RS10965	COG2199	diguanylate cyclase activity
HJ37_RS10965	COG2200	EAL domain
HJ37_RS10970	COG1011	Hydrolase
HJ37_RS10975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HJ37_RS10985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HJ37_RS10990	COG0019	diaminopimelate decarboxylase activity
HJ37_RS11000	COG1965	Belongs to the frataxin family
HJ37_RS11015	COG0181	hydroxymethylbilane synthase activity
HJ37_RS11020	COG1587	Uroporphyrinogen-III synthase
HJ37_RS11025	COG2959	enzyme of heme biosynthesis
HJ37_RS11030	COG3071	HemY protein
HJ37_RS11045	COG3078	GTPase activator activity
HJ37_RS11065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJ37_RS11065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJ37_RS11080	COG0084	hydrolase, TatD family'
HJ37_RS11090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HJ37_RS11100	COG0840	transmembrane signaling receptor activity
HJ37_RS11105	COG1580	Controls the rotational direction of flagella during chemotaxis
HJ37_RS11115	COG3161	chorismate lyase activity
HJ37_RS11120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HJ37_RS11130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HJ37_RS11140	COG0534	Mate efflux family protein
HJ37_RS11145	COG1858	cytochrome C peroxidase
HJ37_RS11150	COG0805	protein transport
HJ37_RS11155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJ37_RS11160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJ37_RS11175	COG2226	methyltransferase
HJ37_RS11180	COG1322	Protein conserved in bacteria
HJ37_RS11190	COG2081	HI0933 family
HJ37_RS11200	COG1528	Iron-storage protein
HJ37_RS11210	COG0589	response to stress
HJ37_RS11230	COG5002	protein histidine kinase activity
HJ37_RS11230	COG5001	Diguanylate cyclase
HJ37_RS11235	COG1522	sequence-specific DNA binding
HJ37_RS11255	COG0006	proline dipeptidase activity
HJ37_RS11255	COG0006	proline dipeptidase activity
HJ37_RS11260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HJ37_RS11265	COG2022	thiamine diphosphate biosynthetic process
HJ37_RS11270	COG2104	thiamine diphosphate biosynthetic process
HJ37_RS11275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HJ37_RS11285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HJ37_RS11290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HJ37_RS11330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HJ37_RS11340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HJ37_RS11345	COG0408	coproporphyrinogen oxidase activity
HJ37_RS11350	COG0009	L-threonylcarbamoyladenylate synthase
HJ37_RS11355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HJ37_RS11360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HJ37_RS11365	COG0551	DNA topoisomerase type I activity
HJ37_RS11370	COG2922	Belongs to the Smg family
HJ37_RS11375	COG0758	DNA mediated transformation
HJ37_RS11380	COG1652	LysM domain
HJ37_RS11385	COG0242	peptide deformylase activity
HJ37_RS11390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HJ37_RS11395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HJ37_RS11395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HJ37_RS11400	COG0569	domain protein
HJ37_RS11405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HJ37_RS11415	COG1272	protein, Hemolysin III
HJ37_RS11420	COG4326	sporulation control protein
HJ37_RS11430	COG3084	Protein conserved in bacteria
HJ37_RS11440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HJ37_RS11445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HJ37_RS11450	COG0204	Acyl-transferase
HJ37_RS11455	COG0606	chelatase, subunit chli
HJ37_RS11470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HJ37_RS11475	COG0129	dihydroxy-acid dehydratase activity
HJ37_RS11485	COG0604	alcohol dehydrogenase
HJ37_RS11495	COG0425	Belongs to the sulfur carrier protein TusA family
HJ37_RS11505	COG2119	membrane
HJ37_RS11510	COG0752	glycyl-tRNA synthetase alpha subunit
HJ37_RS11515	COG0751	glycine-tRNA ligase activity
HJ37_RS11520	COG3977	Valine--pyruvate aminotransferase
HJ37_RS11525	COG0071	Belongs to the small heat shock protein (HSP20) family
HJ37_RS11540	COG0187	DNA topoisomerase II activity
HJ37_RS11545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HJ37_RS11550	COG0592	DNA-directed DNA polymerase activity
HJ37_RS11555	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HJ37_RS11570	COG1126	abc transporter atp-binding protein
HJ37_RS11575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HJ37_RS11580	COG0594	ribonuclease P activity
HJ37_RS11590	COG0706	membrane insertase activity
HJ37_RS11595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HJ37_RS11600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HJ37_RS11610	COG0445	tRNA wobble uridine modification
HJ37_RS11620	COG1192	Involved in chromosome partitioning
HJ37_RS11625	COG1475	DNA binding
HJ37_RS11630	COG3312	ion transport
HJ37_RS11635	COG0356	it plays a direct role in the translocation of protons across the membrane
HJ37_RS11645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HJ37_RS11650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HJ37_RS11655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HJ37_RS11660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HJ37_RS11665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HJ37_RS11670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HJ37_RS11675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HJ37_RS11680	COG2814	Major facilitator Superfamily
HJ37_RS11685	COG0583	DNA-binding transcription factor activity
HJ37_RS11690	COG0183	Belongs to the thiolase family
HJ37_RS11700	COG1739	Uncharacterized protein family UPF0029
HJ37_RS11705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HJ37_RS11710	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HJ37_RS11755	COG0583	DNA-binding transcription factor activity
HJ37_RS11760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HJ37_RS11765	COG2960	long-chain fatty acid transporting porin activity
HJ37_RS11770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HJ37_RS11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HJ37_RS11780	COG1309	transcriptional regulator
HJ37_RS11825	COG0747	negative chemotaxis
HJ37_RS11830	COG0601	transmembrane transport
HJ37_RS11835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJ37_RS11845	COG2131	deaminase
HJ37_RS11870	COG3621	Patatin-like phospholipase
HJ37_RS11910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HJ37_RS11915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HJ37_RS11925	COG0210	DNA helicase
HJ37_RS11930	COG1280	lysine exporter protein (LysE YggA)
HJ37_RS11945	COG2962	Rard protein
HJ37_RS11950	COG0514	ATP-dependent DNA helicase (RecQ)
HJ37_RS11965	COG1132	(ABC) transporter
HJ37_RS11970	COG4774	siderophore transport
HJ37_RS11975	COG1120	ATPase activity
HJ37_RS12000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HJ37_RS12005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HJ37_RS12005	COG1263	PTS System
HJ37_RS12010	COG2862	Uncharacterized protein family, UPF0114
HJ37_RS12015	COG1561	YicC-like family, N-terminal region
HJ37_RS12020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HJ37_RS12025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HJ37_RS12030	COG1560	Kdo2-lipid A biosynthetic process
HJ37_RS12035	COG1560	Kdo2-lipid A biosynthetic process
HJ37_RS12040	COG1309	transcriptional regulator
HJ37_RS12045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HJ37_RS12055	COG2003	Belongs to the UPF0758 family
HJ37_RS12060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HJ37_RS12065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HJ37_RS12075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJ37_RS12080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HJ37_RS12085	COG0859	PFAM glycosyl transferase family 9
HJ37_RS12090	COG0463	Glycosyl transferase, family 2
HJ37_RS12095	COG0859	PFAM glycosyl transferase family 9
HJ37_RS12100	COG3642	lipopolysaccharide core region biosynthetic process
HJ37_RS12130	COG1519	Transferase
HJ37_RS12165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJ37_RS12170	COG0662	Cupin 2, conserved barrel domain protein
HJ37_RS12170	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HJ37_RS12175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HJ37_RS12180	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HJ37_RS12210	COG0318	PFAM AMP-dependent synthetase and ligase
HJ37_RS12215	COG1012	belongs to the aldehyde dehydrogenase family
HJ37_RS12215	COG1454	alcohol dehydrogenase
HJ37_RS12230	COG5433	transposase activity
HJ37_RS12260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HJ37_RS12265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HJ37_RS12270	COG0668	transmembrane transport
HJ37_RS12275	COG1573	uracil-dna glycosylase
HJ37_RS12285	COG3068	Protein conserved in bacteria
HJ37_RS12295	COG1940	carbohydrate kinase activity
HJ37_RS12300	COG1253	flavin adenine dinucleotide binding
HJ37_RS12310	COG0776	regulation of translation
HJ37_RS12320	COG0151	Belongs to the GarS family
HJ37_RS12330	COG0789	Transcriptional regulator
HJ37_RS12335	COG3710	Transcriptional regulator
HJ37_RS12340	COG0531	amino acid
HJ37_RS12345	COG1982	Orn Lys Arg decarboxylase major
HJ37_RS12350	COG0840	transmembrane signaling receptor activity
HJ37_RS12370	COG0800	Aldolase
HJ37_RS12380	COG3265	gluconokinase activity
HJ37_RS12385	COG0129	dihydroxy-acid dehydratase activity
HJ37_RS12390	COG1609	Transcriptional regulator
HJ37_RS12395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HJ37_RS12400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HJ37_RS12405	COG2264	protein methyltransferase activity
HJ37_RS12410	COG0439	Biotin carboxylase
HJ37_RS12415	COG0511	ligase activity, forming carbon-carbon bonds
HJ37_RS12420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HJ37_RS12425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJ37_RS12445	COG2814	Major facilitator Superfamily
HJ37_RS12450	COG0784	Response regulator, receiver
HJ37_RS12450	COG2205	protein histidine kinase activity
HJ37_RS12455	COG0248	Ppx GppA phosphatase
HJ37_RS12460	COG0513	Belongs to the DEAD box helicase family
HJ37_RS12465	COG3118	belongs to the thioredoxin family
HJ37_RS12480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HJ37_RS12525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HJ37_RS12540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HJ37_RS12550	COG1072	(Pantothenic acid kinase))
HJ37_RS12575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HJ37_RS12580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HJ37_RS12585	COG0250	Participates in transcription elongation, termination and antitermination
HJ37_RS12590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HJ37_RS12600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HJ37_RS12605	COG0222	ribosome binding
HJ37_RS12610	COG0085	RNA polymerase activity
HJ37_RS12615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HJ37_RS12620	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HJ37_RS12625	COG2816	NAD+ diphosphatase activity
HJ37_RS12630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HJ37_RS12645	COG4942	peptidase
HJ37_RS12650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HJ37_RS12660	COG0471	metal ion transport
HJ37_RS12665	COG0688	phosphatidylethanolamine metabolic process
HJ37_RS12670	COG1162	GTPase activity
HJ37_RS12675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HJ37_RS12720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HJ37_RS12725	COG0802	atpase or kinase
HJ37_RS12735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HJ37_RS12740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HJ37_RS12745	COG1923	regulation of RNA biosynthetic process
HJ37_RS12750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HJ37_RS12755	COG0330	HflC and HflK could
HJ37_RS12760	COG0330	HflC and HflK could
HJ37_RS12765	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HJ37_RS12770	COG2900	Belongs to the SlyX family
HJ37_RS12780	COG0545	Peptidyl-prolyl cis-trans isomerase
HJ37_RS12785	COG2964	Protein conserved in bacteria
HJ37_RS12790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HJ37_RS12795	COG2923	Belongs to the DsrF TusC family
HJ37_RS12810	COG0049	tRNA binding
HJ37_RS12815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HJ37_RS12820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HJ37_RS12825	COG2906	2 iron, 2 sulfur cluster binding
HJ37_RS12835	COG0360	Binds together with S18 to 16S ribosomal RNA
HJ37_RS12840	COG2965	DNA replication, synthesis of RNA primer
HJ37_RS12845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HJ37_RS12850	COG0359	binds to the 23S rRNA
HJ37_RS12865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HJ37_RS12870	COG0432	Pfam Uncharacterised protein family UPF0047
HJ37_RS12890	COG0735	belongs to the Fur family
HJ37_RS12895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HJ37_RS12920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HJ37_RS12930	COG0175	sulfate reduction
HJ37_RS12975	COG1410	methionine synthase
HJ37_RS12975	COG0646	methionine synthase
HJ37_RS12980	COG0527	aspartate kinase activity
HJ37_RS12985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HJ37_RS12995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HJ37_RS13010	COG0629	single-stranded DNA binding
HJ37_RS13015	COG2199	diguanylate cyclase activity
HJ37_RS13015	COG2200	EAL domain
HJ37_RS13040	COG3409	Peptidoglycan-binding domain 1 protein
HJ37_RS13040	COG3267	Type II secretory pathway component ExeA
HJ37_RS13050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HJ37_RS13055	COG1459	type II secretion system
HJ37_RS13065	COG2165	general secretion pathway protein
HJ37_RS13070	COG2165	general secretion pathway protein
HJ37_RS13100	COG1077	Cell shape determining protein MreB Mrl
HJ37_RS13105	COG1792	Involved in formation and maintenance of cell shape
HJ37_RS13110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HJ37_RS13115	COG0424	maF-like protein
HJ37_RS13125	COG3164	Protein of unknown function
HJ37_RS13130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HJ37_RS13135	COG0312	modulator of DNA gyrase
HJ37_RS13140	COG2235	arginine
HJ37_RS13160	COG0589	response to stress
HJ37_RS13170	COG2358	TRAP transporter, solute receptor (TAXI family
HJ37_RS13175	COG1438	arginine binding
HJ37_RS13180	COG0039	L-malate dehydrogenase activity
HJ37_RS13185	COG0531	amino acid
HJ37_RS13190	COG0531	amino acid
HJ37_RS13195	COG0142	geranyltranstransferase activity
HJ37_RS13200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HJ37_RS13205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HJ37_RS13210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HJ37_RS13215	COG2966	Psort location CytoplasmicMembrane, score
HJ37_RS13220	COG3610	response to peptide
HJ37_RS13230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HJ37_RS13235	COG2967	ApaG domain
HJ37_RS13240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HJ37_RS13245	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HJ37_RS13250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HJ37_RS13255	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HJ37_RS13260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HJ37_RS13315	COG0741	lytic transglycosylase activity
HJ37_RS13320	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HJ37_RS13325	COG1194	a g-specific adenine glycosylase
HJ37_RS13335	COG2066	Belongs to the glutaminase family
HJ37_RS13340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HJ37_RS13345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HJ37_RS13355	COG1872	DUF167
HJ37_RS13360	COG0762	integral membrane protein
HJ37_RS13365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HJ37_RS13370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HJ37_RS13390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HJ37_RS13395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HJ37_RS13400	COG1678	Uncharacterized ACR, COG1678
HJ37_RS13405	COG0189	ligase activity
HJ37_RS13410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HJ37_RS13415	COG2356	endonuclease I
HJ37_RS13425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HJ37_RS13435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HJ37_RS13440	COG0583	DNA-binding transcription factor activity
HJ37_RS13445	COG4771	TonB-dependent receptor
HJ37_RS13450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HJ37_RS13455	COG0126	phosphoglycerate kinase activity
HJ37_RS13460	COG0191	fructose-bisphosphate aldolase activity
HJ37_RS13470	COG0668	transmembrane transport
HJ37_RS13475	COG1279	arginine transmembrane transporter activity
HJ37_RS13495	COG1349	DNA-binding transcription factor activity
HJ37_RS13500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HJ37_RS13505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HJ37_RS13550	COG2207	Transcriptional regulator
HJ37_RS13560	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HJ37_RS13565	COG0582	viral genome integration into host DNA
HJ37_RS13580	COG0358	DNA primase activity
HJ37_RS13585	COG1610	YqeY-like protein
HJ37_RS13590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HJ37_RS13595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HJ37_RS13605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HJ37_RS13610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HJ37_RS13615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HJ37_RS13620	COG1968	undecaprenyl-diphosphatase activity
HJ37_RS13625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HJ37_RS13630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HJ37_RS13635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HJ37_RS13640	COG0585	pseudouridine synthase activity
HJ37_RS13645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HJ37_RS13650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HJ37_RS13660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJ37_RS13665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HJ37_RS13685	COG4208	sulfate ABC transporter
HJ37_RS13690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HJ37_RS13700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HJ37_RS13710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HJ37_RS13715	COG0527	aspartate kinase activity
HJ37_RS13720	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HJ37_RS13770	COG3630	sodium ion export across plasma membrane
HJ37_RS13775	COG5016	pyruvate
HJ37_RS13775	COG0511	ligase activity, forming carbon-carbon bonds
HJ37_RS13780	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HJ37_RS13790	COG1238	metal cluster binding
HJ37_RS13795	COG0612	Peptidase, M16
HJ37_RS13800	COG2918	glutathione biosynthetic process
HJ37_RS13805	COG1854	S-ribosylhomocysteine lyase activity
HJ37_RS13810	COG4536	flavin adenine dinucleotide binding
HJ37_RS13815	COG4137	Cytochrome C assembly protein
HJ37_RS13820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HJ37_RS13825	COG0228	four-way junction DNA binding
HJ37_RS13830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HJ37_RS13835	COG0336	Belongs to the RNA methyltransferase TrmD family
HJ37_RS13840	COG0335	large ribosomal subunit rRNA binding
HJ37_RS13845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HJ37_RS13850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HJ37_RS13860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HJ37_RS13870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HJ37_RS13875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HJ37_RS13880	COG0723	plastoquinol--plastocyanin reductase activity
HJ37_RS13885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HJ37_RS13890	COG2857	Cytochrome c1
HJ37_RS13895	COG0625	glutathione transferase activity
HJ37_RS13900	COG2969	positive regulation of protein catabolic process
HJ37_RS13905	COG2823	Periplasmic or secreted lipoprotein
HJ37_RS13910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HJ37_RS13915	COG0792	nuclease activity
HJ37_RS13920	COG3107	peptidoglycan biosynthetic process
HJ37_RS13925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HJ37_RS13940	COG0288	reversible hydration of carbon dioxide
HJ37_RS13945	COG0659	secondary active sulfate transmembrane transporter activity
HJ37_RS13950	COG1131	(ABC) transporter
HJ37_RS13955	COG0842	Transport permease protein
HJ37_RS13960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HJ37_RS14055	COG0004	ammonium transporteR
HJ37_RS14285	COG2027	D-alanyl-D-alanine carboxypeptidase
HJ37_RS14335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HJ37_RS14375	COG0195	Participates in both transcription termination and antitermination
HJ37_RS14385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HJ37_RS14405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HJ37_RS14435	COG1185	polyribonucleotide nucleotidyltransferase activity
HJ37_RS14695	COG3328	transposase activity
HJ37_RS14765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HJ37_RS15165	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HJ37_RS15205	COG0196	riboflavin kinase activity
HJ37_RS15220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HJ37_RS15330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HJ37_RS15510	COG0517	IMP dehydrogenase activity
HJ37_RS15645	COG0517	IMP dehydrogenase activity
HJ37_RS15645	COG0516	GMP reductase activity
HJ37_RS15730	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HJ37_RS16025	COG3064	Membrane
HJ37_RS16075	COG0443	Heat shock 70 kDa protein
HJ37_RS16150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HJ37_RS16150	COG0047	phosphoribosylformylglycinamidine synthase activity
HJ37_RS16195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HJ37_RS16310	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HJ37_RS16555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HJ37_RS16710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJ37_RS16900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJ37_RS16900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJ37_RS16945	COG2067	long-chain fatty acid transport protein
HJ37_RS17370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HJ37_RS17490	COG4191	Histidine kinase
HJ37_RS17545	COG1301	dicarboxylic acid transport
HJ37_RS17740	COG0417	DNA replication proofreading
HJ37_RS18215	COG0745	RESPONSE REGULATOR receiver
HJ37_RS18240	COG1129	ABC transporter
HJ37_RS18430	COG0602	queuosine metabolic process
HJ37_RS18570	COG0643	Histidine kinase
HJ37_RS18570	COG0784	Response regulator, receiver
HJ37_RS18570	COG2198	Histidine kinase
HJ37_RS18640	COG1538	Outer membrane efflux protein
HJ37_RS18695	COG3675	Pfam Lipase (class 3)