locus-tag	class	description
VC395_RS00010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VC395_RS00015	COG1404	Belongs to the peptidase S8 family
VC395_RS00020	COG4206	TonB-dependent receptor
VC395_RS00050	COG3550	peptidyl-serine autophosphorylation
VC395_RS00105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VC395_RS00130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VC395_RS00145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_RS00150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VC395_RS00155	COG2177	Part of the ABC transporter FtsEX involved in
VC395_RS00160	COG2884	Cell division ATP-binding protein ftsE
VC395_RS00165	COG0552	protein localization to endoplasmic reticulum
VC395_RS00170	COG0742	ribosomal rna small subunit methyltransferase
VC395_RS00205	COG0783	Belongs to the Dps family
VC395_RS00210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VC395_RS00215	COG1280	lysine exporter protein (LysE YggA)
VC395_RS00220	COG2267	carboxylic ester hydrolase activity
VC395_RS00225	COG0561	phosphatase activity
VC395_RS00245	COG2200	EAL domain
VC395_RS00245	COG3287	FIST C domain
VC395_RS00245	COG2199	diguanylate cyclase activity
VC395_RS00250	COG1011	Hydrolase
VC395_RS00255	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VC395_RS00265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VC395_RS00270	COG0019	diaminopimelate decarboxylase activity
VC395_RS00280	COG1965	Belongs to the frataxin family
VC395_RS00295	COG0181	hydroxymethylbilane synthase activity
VC395_RS00300	COG1587	Uroporphyrinogen-III synthase
VC395_RS00305	COG2959	enzyme of heme biosynthesis
VC395_RS00310	COG3071	HemY protein
VC395_RS00325	COG3078	GTPase activator activity
VC395_RS00340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VC395_RS00345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VC395_RS00345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VC395_RS00360	COG0084	hydrolase, TatD family'
VC395_RS00370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VC395_RS00380	COG0840	transmembrane signaling receptor activity
VC395_RS00385	COG1580	Controls the rotational direction of flagella during chemotaxis
VC395_RS00395	COG3161	chorismate lyase activity
VC395_RS00400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VC395_RS00405	COG2937	Belongs to the GPAT DAPAT family
VC395_RS00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VC395_RS00420	COG0534	Mate efflux family protein
VC395_RS00425	COG1858	cytochrome C peroxidase
VC395_RS00430	COG0805	protein transport
VC395_RS00435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VC395_RS00440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VC395_RS00445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VC395_RS00455	COG2226	methyltransferase
VC395_RS00460	COG1322	Protein conserved in bacteria
VC395_RS00470	COG2081	HI0933 family
VC395_RS00480	COG1528	Iron-storage protein
VC395_RS00490	COG0589	response to stress
VC395_RS00510	COG5001	Diguanylate cyclase
VC395_RS00510	COG5002	protein histidine kinase activity
VC395_RS00515	COG1522	sequence-specific DNA binding
VC395_RS00535	COG0006	proline dipeptidase activity
VC395_RS00535	COG0006	proline dipeptidase activity
VC395_RS00540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VC395_RS00545	COG2022	thiamine diphosphate biosynthetic process
VC395_RS00550	COG2104	thiamine diphosphate biosynthetic process
VC395_RS00555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VC395_RS00565	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VC395_RS00570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VC395_RS00610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VC395_RS00620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VC395_RS00625	COG0408	coproporphyrinogen oxidase activity
VC395_RS00630	COG0009	L-threonylcarbamoyladenylate synthase
VC395_RS00635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VC395_RS00640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VC395_RS00645	COG0551	DNA topoisomerase type I activity
VC395_RS00650	COG2922	Belongs to the Smg family
VC395_RS00655	COG0758	DNA mediated transformation
VC395_RS00660	COG1652	LysM domain
VC395_RS00665	COG0242	peptide deformylase activity
VC395_RS00670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VC395_RS00675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VC395_RS00675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VC395_RS00680	COG0569	domain protein
VC395_RS00685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VC395_RS00695	COG1272	protein, Hemolysin III
VC395_RS00700	COG4326	sporulation control protein
VC395_RS00710	COG3084	Protein conserved in bacteria
VC395_RS00720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VC395_RS00725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VC395_RS00730	COG0204	Acyl-transferase
VC395_RS00735	COG0606	chelatase, subunit chli
VC395_RS00750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VC395_RS00755	COG0129	dihydroxy-acid dehydratase activity
VC395_RS00765	COG0604	alcohol dehydrogenase
VC395_RS00775	COG0425	Belongs to the sulfur carrier protein TusA family
VC395_RS00785	COG2119	membrane
VC395_RS00790	COG0752	glycyl-tRNA synthetase alpha subunit
VC395_RS00795	COG0751	glycine-tRNA ligase activity
VC395_RS00800	COG3977	Valine--pyruvate aminotransferase
VC395_RS00805	COG0071	Belongs to the small heat shock protein (HSP20) family
VC395_RS00820	COG0187	DNA topoisomerase II activity
VC395_RS00825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VC395_RS00830	COG0592	DNA-directed DNA polymerase activity
VC395_RS00835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VC395_RS00850	COG1126	abc transporter atp-binding protein
VC395_RS00855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VC395_RS00860	COG0594	ribonuclease P activity
VC395_RS00870	COG0706	membrane insertase activity
VC395_RS00875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VC395_RS00880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VC395_RS00890	COG0445	tRNA wobble uridine modification
VC395_RS00895	COG0357	Ribosomal RNA small subunit methyltransferase G
VC395_RS00900	COG1192	Involved in chromosome partitioning
VC395_RS00905	COG1475	DNA binding
VC395_RS00910	COG3312	ion transport
VC395_RS00915	COG0356	it plays a direct role in the translocation of protons across the membrane
VC395_RS00925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VC395_RS00930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VC395_RS00935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VC395_RS00940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VC395_RS00945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VC395_RS00950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VC395_RS00955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VC395_RS00960	COG2814	Major facilitator Superfamily
VC395_RS00965	COG0583	DNA-binding transcription factor activity
VC395_RS00970	COG0183	Belongs to the thiolase family
VC395_RS00975	COG1024	Enoyl-CoA hydratase
VC395_RS00975	COG1250	3-hydroxyacyl-CoA dehydrogenase
VC395_RS00980	COG1739	Uncharacterized protein family UPF0029
VC395_RS00985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VC395_RS00990	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VC395_RS01035	COG0583	DNA-binding transcription factor activity
VC395_RS01040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VC395_RS01045	COG2960	long-chain fatty acid transporting porin activity
VC395_RS01050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VC395_RS01055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_RS01060	COG1309	transcriptional regulator
VC395_RS01115	COG0747	negative chemotaxis
VC395_RS01120	COG0601	transmembrane transport
VC395_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VC395_RS01135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_RS01140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VC395_RS01150	COG0210	DNA helicase
VC395_RS01155	COG1280	lysine exporter protein (LysE YggA)
VC395_RS01170	COG2962	Rard protein
VC395_RS01175	COG0514	ATP-dependent DNA helicase (RecQ)
VC395_RS01190	COG1132	(ABC) transporter
VC395_RS01195	COG4774	siderophore transport
VC395_RS01200	COG1120	ATPase activity
VC395_RS01225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VC395_RS01230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_RS01230	COG1263	PTS System
VC395_RS01235	COG2862	Uncharacterized protein family, UPF0114
VC395_RS01240	COG1561	YicC-like family, N-terminal region
VC395_RS01245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VC395_RS01250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VC395_RS01255	COG1560	Kdo2-lipid A biosynthetic process
VC395_RS01260	COG1560	Kdo2-lipid A biosynthetic process
VC395_RS01265	COG1309	transcriptional regulator
VC395_RS01270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VC395_RS01280	COG2003	Belongs to the UPF0758 family
VC395_RS01285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VC395_RS01290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VC395_RS01300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VC395_RS01305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VC395_RS01310	COG0859	PFAM glycosyl transferase family 9
VC395_RS01315	COG0463	Glycosyl transferase, family 2
VC395_RS01320	COG0859	PFAM glycosyl transferase family 9
VC395_RS01325	COG3642	lipopolysaccharide core region biosynthetic process
VC395_RS01355	COG1519	Transferase
VC395_RS01390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VC395_RS01395	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VC395_RS01395	COG0662	Cupin 2, conserved barrel domain protein
VC395_RS01400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VC395_RS01405	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VC395_RS01435	COG0318	PFAM AMP-dependent synthetase and ligase
VC395_RS01440	COG1454	alcohol dehydrogenase
VC395_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
VC395_RS01455	COG5433	transposase activity
VC395_RS01460	COG5433	transposase activity
VC395_RS01495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VC395_RS01500	COG0668	transmembrane transport
VC395_RS01505	COG1573	uracil-dna glycosylase
VC395_RS01515	COG3068	Protein conserved in bacteria
VC395_RS01525	COG1940	carbohydrate kinase activity
VC395_RS01530	COG1253	flavin adenine dinucleotide binding
VC395_RS01540	COG0776	regulation of translation
VC395_RS01550	COG0151	Belongs to the GarS family
VC395_RS01555	COG0138	bifunctional purine biosynthesis protein purh
VC395_RS01560	COG0789	Transcriptional regulator
VC395_RS01565	COG3710	Transcriptional regulator
VC395_RS01570	COG0531	amino acid
VC395_RS01575	COG1982	Orn Lys Arg decarboxylase major
VC395_RS01580	COG0840	transmembrane signaling receptor activity
VC395_RS01595	COG0800	Aldolase
VC395_RS01605	COG3265	gluconokinase activity
VC395_RS01610	COG0129	dihydroxy-acid dehydratase activity
VC395_RS01615	COG1609	Transcriptional regulator
VC395_RS01650	COG1857	crispr-associated protein
VC395_RS01660	COG1518	maintenance of DNA repeat elements
VC395_RS01695	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VC395_RS01700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VC395_RS01705	COG2264	protein methyltransferase activity
VC395_RS01710	COG0439	Biotin carboxylase
VC395_RS01715	COG0511	ligase activity, forming carbon-carbon bonds
VC395_RS01720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VC395_RS01725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VC395_RS01745	COG2814	Major facilitator Superfamily
VC395_RS01750	COG0784	Response regulator, receiver
VC395_RS01750	COG2205	protein histidine kinase activity
VC395_RS01755	COG0248	Ppx GppA phosphatase
VC395_RS01760	COG0513	Belongs to the DEAD box helicase family
VC395_RS01765	COG3118	belongs to the thioredoxin family
VC395_RS01780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VC395_RS01825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VC395_RS01840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VC395_RS01850	COG1072	(Pantothenic acid kinase))
VC395_RS01875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VC395_RS01880	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VC395_RS01885	COG0250	Participates in transcription elongation, termination and antitermination
VC395_RS01890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VC395_RS01895	COG0081	regulation of translation
VC395_RS01900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VC395_RS01905	COG0222	ribosome binding
VC395_RS01910	COG0085	RNA polymerase activity
VC395_RS01915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VC395_RS01920	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VC395_RS01925	COG2816	NAD+ diphosphatase activity
VC395_RS01930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VC395_RS01945	COG4942	peptidase
VC395_RS01950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VC395_RS01960	COG0471	metal ion transport
VC395_RS01965	COG0688	phosphatidylethanolamine metabolic process
VC395_RS01970	COG1162	GTPase activity
VC395_RS01975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VC395_RS02020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VC395_RS02025	COG0802	atpase or kinase
VC395_RS02035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VC395_RS02040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VC395_RS02045	COG1923	regulation of RNA biosynthetic process
VC395_RS02050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VC395_RS02055	COG0330	HflC and HflK could
VC395_RS02060	COG0330	HflC and HflK could
VC395_RS02065	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VC395_RS02070	COG2900	Belongs to the SlyX family
VC395_RS02080	COG0545	Peptidyl-prolyl cis-trans isomerase
VC395_RS02085	COG2964	Protein conserved in bacteria
VC395_RS02090	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VC395_RS02095	COG2923	Belongs to the DsrF TusC family
VC395_RS02110	COG0049	tRNA binding
VC395_RS02115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VC395_RS02120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VC395_RS02125	COG2906	2 iron, 2 sulfur cluster binding
VC395_RS02135	COG0360	Binds together with S18 to 16S ribosomal RNA
VC395_RS02140	COG2965	DNA replication, synthesis of RNA primer
VC395_RS02145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VC395_RS02150	COG0359	binds to the 23S rRNA
VC395_RS02165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VC395_RS02170	COG0432	Pfam Uncharacterised protein family UPF0047
VC395_RS02175	COG0166	Belongs to the GPI family
VC395_RS02190	COG0735	belongs to the Fur family
VC395_RS02195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VC395_RS02220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VC395_RS02225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VC395_RS02230	COG0175	sulfate reduction
VC395_RS02270	COG0646	methionine synthase
VC395_RS02270	COG1410	methionine synthase
VC395_RS02275	COG0527	aspartate kinase activity
VC395_RS02280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VC395_RS02290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VC395_RS02305	COG0629	single-stranded DNA binding
VC395_RS02310	COG2199	diguanylate cyclase activity
VC395_RS02310	COG2200	EAL domain
VC395_RS02335	COG3267	Type II secretory pathway component ExeA
VC395_RS02335	COG3409	Peptidoglycan-binding domain 1 protein
VC395_RS02345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_RS02350	COG1459	type II secretion system
VC395_RS02360	COG2165	general secretion pathway protein
VC395_RS02365	COG2165	general secretion pathway protein
VC395_RS02395	COG1077	Cell shape determining protein MreB Mrl
VC395_RS02400	COG1792	Involved in formation and maintenance of cell shape
VC395_RS02405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VC395_RS02410	COG0424	maF-like protein
VC395_RS02420	COG3164	Protein of unknown function
VC395_RS02425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VC395_RS02430	COG0312	modulator of DNA gyrase
VC395_RS02435	COG2235	arginine
VC395_RS02455	COG0589	response to stress
VC395_RS02465	COG2358	TRAP transporter, solute receptor (TAXI family
VC395_RS02470	COG1438	arginine binding
VC395_RS02475	COG0039	L-malate dehydrogenase activity
VC395_RS02480	COG0531	amino acid
VC395_RS02485	COG0142	geranyltranstransferase activity
VC395_RS02490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VC395_RS02495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VC395_RS02500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VC395_RS02505	COG2966	Psort location CytoplasmicMembrane, score
VC395_RS02510	COG3610	response to peptide
VC395_RS02520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VC395_RS02525	COG2967	ApaG domain
VC395_RS02530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VC395_RS02535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VC395_RS02540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VC395_RS02545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VC395_RS02550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VC395_RS02580	COG0840	transmembrane signaling receptor activity
VC395_RS02605	COG0741	lytic transglycosylase activity
VC395_RS02610	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VC395_RS02615	COG1194	a g-specific adenine glycosylase
VC395_RS02620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VC395_RS02625	COG2066	Belongs to the glutaminase family
VC395_RS02630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VC395_RS02635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VC395_RS02645	COG1872	DUF167
VC395_RS02650	COG0762	integral membrane protein
VC395_RS02655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VC395_RS02660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VC395_RS02680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VC395_RS02685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VC395_RS02690	COG1678	Uncharacterized ACR, COG1678
VC395_RS02695	COG0189	ligase activity
VC395_RS02700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VC395_RS02705	COG2356	endonuclease I
VC395_RS02710	COG3091	SprT-like family
VC395_RS02715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VC395_RS02725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VC395_RS02730	COG0583	DNA-binding transcription factor activity
VC395_RS02735	COG4771	TonB-dependent receptor
VC395_RS02740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VC395_RS02745	COG0126	phosphoglycerate kinase activity
VC395_RS02750	COG0191	fructose-bisphosphate aldolase activity
VC395_RS02760	COG0668	transmembrane transport
VC395_RS02765	COG1279	arginine transmembrane transporter activity
VC395_RS02770	COG0583	DNA-binding transcription factor activity
VC395_RS02785	COG1349	DNA-binding transcription factor activity
VC395_RS02790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VC395_RS02795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VC395_RS02815	COG0358	DNA primase activity
VC395_RS02820	COG1610	YqeY-like protein
VC395_RS02825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VC395_RS02830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VC395_RS02840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VC395_RS02845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VC395_RS02850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VC395_RS02855	COG1968	undecaprenyl-diphosphatase activity
VC395_RS02860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VC395_RS02865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VC395_RS02870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VC395_RS02875	COG0585	pseudouridine synthase activity
VC395_RS02880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VC395_RS02885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VC395_RS02895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VC395_RS02900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VC395_RS02920	COG4208	sulfate ABC transporter
VC395_RS02925	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VC395_RS02935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VC395_RS02940	COG2137	regulation of response to DNA damage stimulus
VC395_RS02945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VC395_RS02950	COG0527	aspartate kinase activity
VC395_RS02955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VC395_RS03005	COG3630	sodium ion export across plasma membrane
VC395_RS03010	COG0511	ligase activity, forming carbon-carbon bonds
VC395_RS03010	COG5016	pyruvate
VC395_RS03015	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VC395_RS03025	COG1238	metal cluster binding
VC395_RS03030	COG0612	Peptidase, M16
VC395_RS03035	COG2918	glutathione biosynthetic process
VC395_RS03040	COG1854	S-ribosylhomocysteine lyase activity
VC395_RS03045	COG4536	flavin adenine dinucleotide binding
VC395_RS03050	COG4137	Cytochrome C assembly protein
VC395_RS03055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VC395_RS03060	COG0228	four-way junction DNA binding
VC395_RS03065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VC395_RS03070	COG0336	Belongs to the RNA methyltransferase TrmD family
VC395_RS03075	COG0335	large ribosomal subunit rRNA binding
VC395_RS03080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VC395_RS03085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VC395_RS03095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VC395_RS03105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VC395_RS03110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VC395_RS03115	COG0723	plastoquinol--plastocyanin reductase activity
VC395_RS03120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VC395_RS03125	COG2857	Cytochrome c1
VC395_RS03130	COG0625	glutathione transferase activity
VC395_RS03135	COG2969	positive regulation of protein catabolic process
VC395_RS03140	COG2823	Periplasmic or secreted lipoprotein
VC395_RS03145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VC395_RS03150	COG0792	nuclease activity
VC395_RS03155	COG3107	peptidoglycan biosynthetic process
VC395_RS03160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VC395_RS03175	COG0288	reversible hydration of carbon dioxide
VC395_RS03180	COG0659	secondary active sulfate transmembrane transporter activity
VC395_RS03185	COG1131	(ABC) transporter
VC395_RS03190	COG0842	Transport permease protein
VC395_RS03195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VC395_RS03200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VC395_RS03205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VC395_RS03215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VC395_RS03225	COG1489	DNA binding
VC395_RS03235	COG1643	Atp-dependent helicase
VC395_RS03240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VC395_RS03245	COG1752	Esterase of the alpha-beta hydrolase superfamily
VC395_RS03250	COG1049	propionate catabolic process, 2-methylcitrate cycle
VC395_RS03255	COG3112	Uncharacterised protein family (UPF0231)
VC395_RS03260	COG0347	Belongs to the P(II) protein family
VC395_RS03265	COG0004	ammonium transporteR
VC395_RS03270	COG1840	ABC-type Fe3 transport system, periplasmic component
VC395_RS03280	COG3842	ATPase activity
VC395_RS03285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VC395_RS03300	COG2971	BadF BadG BcrA BcrD
VC395_RS03310	COG4608	Belongs to the ABC transporter superfamily
VC395_RS03315	COG0444	Belongs to the ABC transporter superfamily
VC395_RS03320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VC395_RS03325	COG0601	transmembrane transport
VC395_RS03330	COG0747	negative chemotaxis
VC395_RS03340	COG2205	protein histidine kinase activity
VC395_RS03340	COG0784	Response regulator, receiver
VC395_RS03345	COG2813	Specifically methylates the guanine in position
VC395_RS03350	COG0628	permease
VC395_RS03360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VC395_RS03365	COG0316	Belongs to the HesB IscA family
VC395_RS03380	COG0739	heme binding
VC395_RS03385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VC395_RS03390	COG2027	D-alanyl-D-alanine carboxypeptidase
VC395_RS03395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VC395_RS03400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VC395_RS03405	COG1534	Rna-binding protein
VC395_RS03410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VC395_RS03415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VC395_RS03420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VC395_RS03425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VC395_RS03430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VC395_RS03445	COG0779	Required for maturation of 30S ribosomal subunits
VC395_RS03450	COG0195	Participates in both transcription termination and antitermination
VC395_RS03455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VC395_RS03460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VC395_RS03465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VC395_RS03470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VC395_RS03475	COG1185	polyribonucleotide nucleotidyltransferase activity
VC395_RS03495	COG0826	peptidase U32
VC395_RS03500	COG0826	peptidase U32
VC395_RS03510	COG3154	lipid carrier protein
VC395_RS03515	COG3153	acetyltransferase
VC395_RS03535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VC395_RS03540	COG0513	Belongs to the DEAD box helicase family
VC395_RS03555	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VC395_RS03560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VC395_RS03565	COG2204	response regulator
VC395_RS03575	COG0667	Aldo Keto reductase
VC395_RS03580	COG3066	DNA modification
VC395_RS03585	COG0494	nUDIX hydrolase
VC395_RS03590	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VC395_RS03595	COG0730	response to heat
VC395_RS03600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VC395_RS03605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VC395_RS03610	COG1283	sodium-dependent phosphate transmembrane transporter activity
VC395_RS03615	COG0583	DNA-binding transcription factor activity
VC395_RS03620	COG0640	Transcriptional regulator
VC395_RS03625	COG0268	Binds directly to 16S ribosomal RNA
VC395_RS03630	COG0728	peptidoglycan biosynthetic process
VC395_RS03635	COG0196	riboflavin kinase activity
VC395_RS03640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VC395_RS03645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VC395_RS03650	COG1047	Peptidyl-prolyl cis-trans
VC395_RS03655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VC395_RS03660	COG1966	Carbon starvation protein
VC395_RS03675	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VC395_RS03680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VC395_RS03685	COG1472	Belongs to the glycosyl hydrolase 3 family
VC395_RS03690	COG3279	Response regulator of the LytR AlgR family
VC395_RS03695	COG3275	phosphorelay sensor kinase activity
VC395_RS03700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VC395_RS03705	COG0287	Prephenate dehydrogenase
VC395_RS03705	COG1605	Chorismate mutase
VC395_RS03715	COG0488	(ABC) transporter
VC395_RS03725	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VC395_RS03735	COG5001	Diguanylate cyclase
VC395_RS03740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VC395_RS03745	COG1605	Chorismate mutase
VC395_RS03745	COG0077	Prephenate dehydratase
VC395_RS03750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VC395_RS03755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VC395_RS03760	COG0564	pseudouridine synthase activity
VC395_RS03765	COG1496	oxidoreductase activity
VC395_RS03770	COG0542	response to heat
VC395_RS03810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VC395_RS03815	COG0826	peptidase U32
VC395_RS03825	COG0745	RESPONSE REGULATOR receiver
VC395_RS03830	COG5002	protein histidine kinase activity
VC395_RS03840	COG0248	Ppx GppA phosphatase
VC395_RS03845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VC395_RS03855	COG0581	inorganic phosphate transmembrane transporter activity
VC395_RS03860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VC395_RS03875	COG3142	Participates in the control of copper homeostasis
VC395_RS03880	COG0450	alkyl hydroperoxide reductase
VC395_RS03885	COG0583	DNA-binding transcription factor activity
VC395_RS03890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VC395_RS03900	COG0517	IMP dehydrogenase activity
VC395_RS03905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VC395_RS03915	COG0343	queuine tRNA-ribosyltransferase activity
VC395_RS03920	COG1862	Preprotein translocase
VC395_RS03925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VC395_RS03930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VC395_RS03935	COG0483	inositol monophosphate 1-phosphatase activity
VC395_RS03945	COG1959	2 iron, 2 sulfur cluster binding
VC395_RS03950	COG1104	cysteine desulfurase activity
VC395_RS03955	COG0822	iron-sulfur transferase activity
VC395_RS03965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VC395_RS03970	COG0443	Heat shock 70 kDa protein
VC395_RS03975	COG0633	Ferredoxin
VC395_RS03980	COG2975	iron-sulfur cluster assembly
VC395_RS03985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VC395_RS03990	COG0105	UTP biosynthetic process
VC395_RS03995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VC395_RS04005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VC395_RS04010	COG0124	histidyl-tRNA synthetase
VC395_RS04015	COG2976	Protein conserved in bacteria
VC395_RS04020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VC395_RS04025	COG1160	GTP binding
VC395_RS04040	COG1570	exodeoxyribonuclease VII activity
VC395_RS04045	COG0516	GMP reductase activity
VC395_RS04045	COG0517	IMP dehydrogenase activity
VC395_RS04050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VC395_RS04050	COG0519	Catalyzes the synthesis of GMP from XMP
VC395_RS04060	COG1584	GPR1 FUN34 yaaH family protein
VC395_RS04065	COG3433	isochorismatase activity
VC395_RS04065	COG1535	isochorismatase
VC395_RS04070	COG1021	2,3-dihydroxybenzoate-AMP ligase
VC395_RS04075	COG1169	isochorismate synthase
VC395_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
VC395_RS04090	COG4592	Periplasmic binding protein
VC395_RS04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VC395_RS04100	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VC395_RS04105	COG1120	ATPase activity
VC395_RS04115	COG0583	DNA-binding transcription factor activity
VC395_RS04120	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VC395_RS04125	COG1115	amino acid carrier protein
VC395_RS04130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VC395_RS04135	COG0583	DNA-binding transcription factor activity
VC395_RS04150	COG4565	transcriptional regulatory protein
VC395_RS04160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VC395_RS04165	COG0511	ligase activity, forming carbon-carbon bonds
VC395_RS04165	COG5016	pyruvate
VC395_RS04170	COG3630	sodium ion export across plasma membrane
VC395_RS04180	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VC395_RS04185	COG3052	prosthetic group binding
VC395_RS04190	COG2301	Belongs to the HpcH HpaI aldolase family
VC395_RS04195	COG3051	citrate lyase alpha subunit
VC395_RS04200	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
VC395_RS04215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VC395_RS04220	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VC395_RS04225	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VC395_RS04295	COG1012	belongs to the aldehyde dehydrogenase family
VC395_RS04315	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VC395_RS04320	COG0840	transmembrane signaling receptor activity
VC395_RS04325	COG3710	Transcriptional regulator
VC395_RS04350	COG4796	Type ii and iii secretion system protein
VC395_RS04370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_RS04375	COG1459	type II secretion system
VC395_RS04385	COG2207	Transcriptional regulator
VC395_RS04390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VC395_RS04410	COG0739	heme binding
VC395_RS04420	COG3064	Membrane
VC395_RS04425	COG3064	Membrane
VC395_RS04435	COG0582	viral genome integration into host DNA
VC395_RS04440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VC395_RS04445	COG2867	negative regulation of translational initiation
VC395_RS04450	COG2914	Belongs to the UPF0125 (RnfH) family
VC395_RS04455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VC395_RS04460	COG0497	DNA recombination
VC395_RS04465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VC395_RS04470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VC395_RS04475	COG0443	Heat shock 70 kDa protein
VC395_RS04480	COG0484	heat shock protein binding
VC395_RS04515	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VC395_RS04530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VC395_RS04540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VC395_RS04540	COG0047	phosphoribosylformylglycinamidine synthase activity
VC395_RS04570	COG0442	prolyl-tRNA aminoacylation
VC395_RS04575	COG1720	tRNA m6t6A37 methyltransferase activity
VC395_RS04580	COG0254	rRNA binding
VC395_RS04585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VC395_RS04590	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VC395_RS04595	COG1671	Belongs to the UPF0178 family
VC395_RS04605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VC395_RS04620	COG3098	single-species biofilm formation
VC395_RS04625	COG0564	pseudouridine synthase activity
VC395_RS04630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VC395_RS04635	COG0142	geranyltranstransferase activity
VC395_RS04640	COG1722	exodeoxyribonuclease VII activity
VC395_RS04645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VC395_RS04655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VC395_RS04655	COG0301	tRNA thio-modification
VC395_RS04665	COG0583	DNA-binding transcription factor activity
VC395_RS04670	COG2363	Small membrane protein
VC395_RS04675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VC395_RS04680	COG1611	Belongs to the LOG family
VC395_RS04695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VC395_RS04695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VC395_RS04705	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VC395_RS04710	COG1464	Belongs to the NlpA lipoprotein family
VC395_RS04715	COG2011	ABC-type metal ion transport system permease component
VC395_RS04720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VC395_RS04725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VC395_RS04730	COG1609	Transcriptional regulator
VC395_RS04735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_RS04735	COG1263	PTS System
VC395_RS04740	COG0366	Alpha amylase catalytic
VC395_RS04770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VC395_RS04775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VC395_RS04780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VC395_RS04785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VC395_RS04790	COG0110	maltose O-acetyltransferase activity
VC395_RS04815	COG1045	serine acetyltransferase
VC395_RS04825	COG0438	transferase activity, transferring glycosyl groups
VC395_RS04835	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VC395_RS04865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VC395_RS04875	COG1596	polysaccharide export
VC395_RS04900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VC395_RS04910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VC395_RS04915	COG0321	lipoyl(octanoyl) transferase activity
VC395_RS04920	COG2921	Belongs to the UPF0250 family
VC395_RS04930	COG1686	Belongs to the peptidase S11 family
VC395_RS04935	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VC395_RS04940	COG0772	Belongs to the SEDS family
VC395_RS04945	COG0768	penicillin binding
VC395_RS04950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VC395_RS04955	COG0799	negative regulation of ribosome biogenesis
VC395_RS04960	COG1466	dna polymerase III delta subunit
VC395_RS04965	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VC395_RS04970	COG0495	leucyl-tRNA aminoacylation
VC395_RS04975	COG2888	peptidyl-tyrosine sulfation
VC395_RS04980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VC395_RS04985	COG4535	Mg2 and Co2 transporter CorC
VC395_RS04990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VC395_RS04995	COG1702	phosphate starvation-inducible protein PhoH
VC395_RS05000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VC395_RS05005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_RS05010	COG2190	(PTS) system
VC395_RS05020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_RS05030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VC395_RS05035	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VC395_RS05040	COG3115	cell septum assembly
VC395_RS05045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VC395_RS05060	COG0789	Transcriptional regulator
VC395_RS05065	COG1585	Membrane protein implicated in regulation of membrane protease activity
VC395_RS05070	COG0330	HflC and HflK could
VC395_RS05075	COG3118	belongs to the thioredoxin family
VC395_RS05080	COG0300	oxidoreductase activity
VC395_RS05085	COG1090	epimerase
VC395_RS05090	COG0622	Phosphoesterase
VC395_RS05105	COG3710	Transcriptional regulator
VC395_RS05110	COG0326	Molecular chaperone. Has ATPase activity
VC395_RS05115	COG0563	adenylate kinase activity
VC395_RS05120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VC395_RS05135	COG0367	asparagine synthase
VC395_RS05140	COG4651	solute:proton antiporter activity
VC395_RS05140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VC395_RS05145	COG1846	Transcriptional regulator
VC395_RS05145	COG1940	carbohydrate kinase activity
VC395_RS05150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VC395_RS05155	COG1263	PTS System
VC395_RS05155	COG2190	(PTS) system
VC395_RS05155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_RS05160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VC395_RS05170	COG0101	tRNA pseudouridine synthase activity
VC395_RS05175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VC395_RS05180	COG0285	dihydrofolate synthase activity
VC395_RS05185	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VC395_RS05190	COG1286	toxin biosynthetic process
VC395_RS05195	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VC395_RS05200	COG2056	Na+-H+ antiporter family
VC395_RS05205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VC395_RS05225	COG0346	lactoylglutathione lyase activity
VC395_RS05230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VC395_RS05235	COG4660	Part of a membrane complex involved in electron transport
VC395_RS05240	COG4659	FMN binding
VC395_RS05245	COG4658	electron transport chain
VC395_RS05250	COG4656	Part of a membrane complex involved in electron transport
VC395_RS05255	COG2878	Part of a membrane complex involved in electron transport
VC395_RS05260	COG4657	Part of a membrane complex involved in electron transport
VC395_RS05270	COG0556	nucleotide-excision repair
VC395_RS05280	COG2204	response regulator
VC395_RS05285	COG2198	Histidine kinase
VC395_RS05290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VC395_RS05295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VC395_RS05300	COG0521	Mo-molybdopterin cofactor biosynthetic process
VC395_RS05305	COG0315	cyclic pyranopterin monophosphate synthase activity
VC395_RS05310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VC395_RS05315	COG0314	molybdopterin synthase activity
VC395_RS05320	COG2199	diguanylate cyclase activity
VC395_RS05325	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VC395_RS05325	COG0617	tRNA 3'-terminal CCA addition
VC395_RS05325	COG0517	IMP dehydrogenase activity
VC395_RS05340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VC395_RS05350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_RS05350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_RS05355	COG0489	protein tyrosine kinase activity
VC395_RS05360	COG0572	uridine kinase
VC395_RS05365	COG2982	Protein involved in outer membrane biogenesis
VC395_RS05370	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VC395_RS05375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VC395_RS05385	COG2067	long-chain fatty acid transport protein
VC395_RS05405	COG0183	Belongs to the thiolase family
VC395_RS05410	COG1024	Enoyl-CoA hydratase
VC395_RS05410	COG1250	3-hydroxyacyl-CoA dehydrogenase
VC395_RS05415	COG0778	Nitroreductase
VC395_RS05420	COG0583	DNA-binding transcription factor activity
VC395_RS05425	COG0745	RESPONSE REGULATOR receiver
VC395_RS05435	COG2832	Protein of unknown function (DUF454)
VC395_RS05440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VC395_RS05445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VC395_RS05450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VC395_RS05455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VC395_RS05465	COG2983	Belongs to the UPF0260 family
VC395_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
VC395_RS05475	COG0616	signal peptide processing
VC395_RS05485	COG1522	sequence-specific DNA binding
VC395_RS05490	COG1946	Acyl-CoA thioesterase
VC395_RS05510	COG3706	GGDEF domain
VC395_RS05515	COG0640	Transcriptional regulator
VC395_RS05520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VC395_RS05545	COG1881	PFAM PEBP family protein
VC395_RS05565	COG0009	L-threonylcarbamoyladenylate synthase
VC395_RS05580	COG2201	protein-glutamate methylesterase activity
VC395_RS05590	COG5002	protein histidine kinase activity
VC395_RS05595	COG4191	Histidine kinase
VC395_RS05600	COG3300	MHYT domain
VC395_RS05600	COG5001	Diguanylate cyclase
VC395_RS05605	COG2204	response regulator
VC395_RS05625	COG0601	transmembrane transport
VC395_RS05630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VC395_RS05635	COG0444	Belongs to the ABC transporter superfamily
VC395_RS05640	COG4608	Belongs to the ABC transporter superfamily
VC395_RS05645	COG0435	Glutathione S-transferase
VC395_RS05650	COG0280	phosphate acetyltransferase
VC395_RS05650	COG0857	belongs to the CobB CobQ family
VC395_RS05655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VC395_RS05660	COG3092	negative regulation of chromosome organization
VC395_RS05665	COG4628	conserved protein (DUF2132)
VC395_RS05675	COG4120	Belongs to the binding-protein-dependent transport system permease family
VC395_RS05685	COG2203	Gaf domain
VC395_RS05685	COG2199	diguanylate cyclase activity
VC395_RS05695	COG0653	protein targeting
VC395_RS05700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VC395_RS05705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VC395_RS05710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VC395_RS05715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VC395_RS05720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VC395_RS05725	COG0156	8-amino-7-oxononanoate synthase activity
VC395_RS05730	COG2226	methyltransferase
VC395_RS05735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VC395_RS05745	COG0501	Belongs to the peptidase M48B family
VC395_RS05755	COG0300	oxidoreductase activity
VC395_RS05770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VC395_RS05780	COG2268	Band 7 protein
VC395_RS05790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VC395_RS05795	COG2915	High frequency lysogenization protein hflD homolog
VC395_RS05800	COG0482	sulfurtransferase activity
VC395_RS05805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VC395_RS05815	COG3423	Transcriptional regulator
VC395_RS05820	COG2801	Transposase and inactivated derivatives
VC395_RS05825	COG2842	Transposition protein
VC395_RS05930	COG0640	Transcriptional regulator
VC395_RS05940	COG4373	Mu-like prophage FluMu protein gp28
VC395_RS05945	COG4383	Mu-like prophage protein gp29
VC395_RS05985	COG4397	Mu-like prophage major head subunit gpT
VC395_RS05995	COG4387	Mu-like prophage protein GP36
VC395_RS06015	COG4386	tail sheath protein
VC395_RS06025	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
VC395_RS06045	COG4384	Bacteriophage Mu Gp45 protein
VC395_RS06055	COG3299	homolog of phage Mu protein gp47
VC395_RS06060	COG3778	Protein conserved in bacteria
VC395_RS06075	COG2916	Histone family protein nucleoid-structuring protein H-NS
VC395_RS06080	COG1757	Na H antiporter
VC395_RS06085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VC395_RS06090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VC395_RS06095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VC395_RS06100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VC395_RS06100	COG0131	Imidazoleglycerol-phosphate dehydratase
VC395_RS06105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VC395_RS06110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VC395_RS06115	COG0107	imidazoleglycerol-phosphate synthase activity
VC395_RS06120	COG0140	phosphoribosyl-ATP diphosphatase activity
VC395_RS06120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VC395_RS06125	COG1187	pseudouridine synthase activity
VC395_RS06135	COG1278	Cold shock
VC395_RS06140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VC395_RS06145	COG0542	response to heat
VC395_RS06150	COG2985	domain, Protein
VC395_RS06150	COG3273	potassium ion transport
VC395_RS06155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VC395_RS06160	COG1012	belongs to the aldehyde dehydrogenase family
VC395_RS06160	COG1454	alcohol dehydrogenase
VC395_RS06165	COG1737	Transcriptional regulator
VC395_RS06170	COG0076	glutamate decarboxylase activity
VC395_RS06180	COG2431	L-lysine efflux transmembrane transporter activity
VC395_RS06190	COG3070	regulator of competence-specific genes
VC395_RS06205	COG3852	Histidine kinase
VC395_RS06215	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VC395_RS06230	COG0189	ligase activity
VC395_RS06230	COG4067	protein conserved in archaea
VC395_RS06235	COG0500	methyltransferase
VC395_RS06240	COG4106	trans-aconitate 2-methyltransferase activity
VC395_RS06245	COG1801	Protein of unknown function DUF72
VC395_RS06250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VC395_RS06255	COG1435	thymidine kinase activity
VC395_RS06260	COG1301	dicarboxylic acid transport
VC395_RS06275	COG3778	Protein conserved in bacteria
VC395_RS06280	COG3299	homolog of phage Mu protein gp47
VC395_RS06290	COG4384	Bacteriophage Mu Gp45 protein
VC395_RS06310	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
VC395_RS06320	COG4386	tail sheath protein
VC395_RS06340	COG4387	Mu-like prophage protein GP36
VC395_RS06350	COG4397	Mu-like prophage major head subunit gpT
VC395_RS06390	COG4383	Mu-like prophage protein gp29
VC395_RS06395	COG4373	Mu-like prophage FluMu protein gp28
VC395_RS06405	COG0640	Transcriptional regulator
VC395_RS06510	COG2842	Transposition protein
VC395_RS06515	COG2801	Transposase and inactivated derivatives
VC395_RS06520	COG3423	Transcriptional regulator
VC395_RS06535	COG0159	tryptophan synthase activity
VC395_RS06540	COG0133	tryptophan synthase activity
VC395_RS06545	COG0134	indole-3-glycerol-phosphate synthase activity
VC395_RS06545	COG0135	phosphoribosylanthranilate isomerase activity
VC395_RS06550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VC395_RS06555	COG0512	Glutamine amidotransferase of anthranilate synthase
VC395_RS06560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VC395_RS06570	COG0613	PHP domain protein
VC395_RS06575	COG0009	L-threonylcarbamoyladenylate synthase
VC395_RS06580	COG1187	pseudouridine synthase activity
VC395_RS06585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VC395_RS06590	COG4988	ABC transporter
VC395_RS06595	COG0492	ferredoxin-NADP+ reductase activity
VC395_RS06610	COG3706	GGDEF domain
VC395_RS06615	COG2949	membrane
VC395_RS06625	COG0281	malic enzyme
VC395_RS06635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VC395_RS06655	COG2885	chlorophyll binding
VC395_RS06670	COG0247	lactate metabolic process
VC395_RS06670	COG0277	FAD linked oxidase domain protein
VC395_RS06690	COG2986	histidine ammonia-lyase
VC395_RS06695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VC395_RS06700	COG0010	Belongs to the arginase family
VC395_RS06705	COG1228	amidohydrolase
VC395_RS06720	COG3099	Belongs to the UPF0263 family
VC395_RS06725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VC395_RS06735	COG5001	Diguanylate cyclase
VC395_RS06740	COG0417	DNA replication proofreading
VC395_RS06745	COG2197	response regulator
VC395_RS06750	COG0322	excinuclease ABC activity
VC395_RS06790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VC395_RS06795	COG0072	phenylalanine-tRNA ligase activity
VC395_RS06795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_RS06800	COG0776	regulation of translation
VC395_RS06815	COG0500	methyltransferase
VC395_RS06835	COG0295	cytidine deaminase activity
VC395_RS06840	COG1346	cytolysis
VC395_RS06845	COG1380	Effector of murein hydrolase LrgA
VC395_RS06850	COG2925	Exonuclease
VC395_RS06855	COG1823	symporter activity
VC395_RS06860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_RS06865	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VC395_RS06870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VC395_RS06885	COG2988	succinylglutamate desuccinylase activity
VC395_RS06890	COG4139	cobalamin transport
VC395_RS06895	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VC395_RS06940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VC395_RS06945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VC395_RS06950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VC395_RS06960	COG1054	Belongs to the UPF0176 family
VC395_RS06970	COG2814	Major facilitator Superfamily
VC395_RS06980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VC395_RS07010	COG3108	Peptidase M15
VC395_RS07015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VC395_RS07030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VC395_RS07055	COG1846	Transcriptional regulator
VC395_RS07060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VC395_RS07065	COG0726	polysaccharide deacetylase
VC395_RS07070	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VC395_RS07080	COG1447	Phosphotransferase system cellobiose-specific component IIA
VC395_RS07085	COG1486	melibiose metabolic process
VC395_RS07090	COG3394	polysaccharide catabolic process
VC395_RS07095	COG1609	Transcriptional regulator
VC395_RS07100	COG2943	transferase activity, transferring hexosyl groups
VC395_RS07105	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VC395_RS07110	COG0840	transmembrane signaling receptor activity
VC395_RS07125	COG1448	Aminotransferase
VC395_RS07135	COG3437	response regulator, receiver
VC395_RS07135	COG2770	Histidine kinase
VC395_RS07140	COG0352	thiamine-phosphate diphosphorylase activity
VC395_RS07140	COG0351	phosphomethylpyrimidine kinase
VC395_RS07145	COG0017	Asparaginyl-tRNA synthetase
VC395_RS07150	COG0840	transmembrane signaling receptor activity
VC395_RS07155	COG0720	synthase
VC395_RS07160	COG1760	l-serine dehydratase
VC395_RS07165	COG0814	amino acid
VC395_RS07170	COG0494	nUDIX hydrolase
VC395_RS07175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VC395_RS07190	COG3106	COG3106 Predicted ATPase
VC395_RS07195	COG3768	UPF0283 membrane protein
VC395_RS07205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VC395_RS07220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VC395_RS07230	COG0471	metal ion transport
VC395_RS07235	COG4191	Histidine kinase
VC395_RS07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VC395_RS07245	COG2990	Protein conserved in bacteria
VC395_RS07250	COG3713	MltA-interacting MipA family protein
VC395_RS07255	COG2205	protein histidine kinase activity
VC395_RS07260	COG0745	RESPONSE REGULATOR receiver
VC395_RS07295	COG1129	ABC transporter
VC395_RS07335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VC395_RS07340	COG0372	Belongs to the citrate synthase family
VC395_RS07370	COG2195	Cleaves the N-terminal amino acid of tripeptides
VC395_RS07380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VC395_RS07390	COG0625	glutathione transferase activity
VC395_RS07395	COG3437	response regulator, receiver
VC395_RS07400	COG3850	Histidine kinase
VC395_RS07400	COG2205	protein histidine kinase activity
VC395_RS07400	COG3437	response regulator, receiver
VC395_RS07400	COG4999	Histidine kinase
VC395_RS07415	COG3706	GGDEF domain
VC395_RS07420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VC395_RS07425	COG1254	Belongs to the acylphosphatase family
VC395_RS07430	COG2920	part of a sulfur-relay system
VC395_RS07435	COG0670	Belongs to the BI1 family
VC395_RS07440	COG1126	abc transporter atp-binding protein
VC395_RS07445	COG0765	amino acid transport
VC395_RS07450	COG4597	amino acid ABC transporter
VC395_RS07455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VC395_RS07465	COG0561	phosphatase activity
VC395_RS07470	COG0602	queuosine metabolic process
VC395_RS07475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VC395_RS07505	COG3706	GGDEF domain
VC395_RS07510	COG0443	Heat shock 70 kDa protein
VC395_RS07560	COG1643	Atp-dependent helicase
VC395_RS07570	COG0443	Heat shock 70 kDa protein
VC395_RS07575	COG0095	Lipoate-protein ligase
VC395_RS07585	COG0583	DNA-binding transcription factor activity
VC395_RS07590	COG0477	Major facilitator Superfamily
VC395_RS07595	COG0415	Belongs to the DNA photolyase family
VC395_RS07610	COG0745	RESPONSE REGULATOR receiver
VC395_RS07620	COG0643	Histidine kinase
VC395_RS07620	COG2198	Histidine kinase
VC395_RS07625	COG2198	Histidine kinase
VC395_RS07625	COG0643	Histidine kinase
VC395_RS07625	COG0784	Response regulator, receiver
VC395_RS07630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VC395_RS07640	COG2201	protein-glutamate methylesterase activity
VC395_RS07645	COG0835	chemotaxis
VC395_RS07650	COG3290	protein histidine kinase activity
VC395_RS07650	COG0840	transmembrane signaling receptor activity
VC395_RS07655	COG0840	transmembrane signaling receptor activity
VC395_RS07665	COG0513	Belongs to the DEAD box helicase family
VC395_RS07675	COG1538	Outer membrane efflux protein
VC395_RS07680	COG1566	PFAM secretion protein HlyD family protein
VC395_RS07685	COG2814	Major facilitator Superfamily
VC395_RS07690	COG0840	transmembrane signaling receptor activity
VC395_RS07695	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VC395_RS07705	COG3501	Rhs element vgr protein
VC395_RS07715	COG3675	Pfam Lipase (class 3)
VC395_RS07730	COG1280	lysine exporter protein (LysE YggA)
VC395_RS07735	COG1115	amino acid carrier protein
VC395_RS07750	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VC395_RS07760	COG1177	transmembrane transport
VC395_RS07770	COG3842	ATPase activity
VC395_RS07790	COG0037	tRNA processing
VC395_RS07795	COG0589	response to stress
VC395_RS07800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VC395_RS07815	COG2217	Heavy metal translocating P-type atpase
VC395_RS07825	COG2010	Cytochrome c
VC395_RS07840	COG3278	Belongs to the heme-copper respiratory oxidase family
VC395_RS07855	COG2205	protein histidine kinase activity
VC395_RS07855	COG0784	Response regulator, receiver
VC395_RS07870	COG2274	protein secretion by the type I secretion system
VC395_RS07875	COG1073	alpha beta
VC395_RS07875	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VC395_RS07875	COG3064	Membrane
VC395_RS07890	COG4128	Pfam Zonular occludens toxin
VC395_RS08040	COG3120	sequence-specific DNA binding
VC395_RS08045	COG1067	ATP-dependent peptidase activity
VC395_RS08050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VC395_RS08065	COG0488	(ABC) transporter
VC395_RS08075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VC395_RS08075	COG0116	Belongs to the methyltransferase superfamily
VC395_RS08085	COG0167	dihydroorotate dehydrogenase activity
VC395_RS08090	COG2902	Dehydrogenase
VC395_RS08105	COG0308	aminopeptidase N
VC395_RS08120	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VC395_RS08125	COG1956	GAF domain-containing protein
VC395_RS08130	COG1132	(ABC) transporter
VC395_RS08135	COG2995	paraquat-inducible protein a
VC395_RS08140	COG3008	intermembrane lipid transfer
VC395_RS08150	COG2996	Protein conserved in bacteria
VC395_RS08165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VC395_RS08170	COG1666	GTP binding
VC395_RS08175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VC395_RS08190	COG0437	4 iron, 4 sulfur cluster binding
VC395_RS08195	COG3383	formate dehydrogenase (NAD+) activity
VC395_RS08195	COG0243	molybdopterin cofactor binding
VC395_RS08225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VC395_RS08230	COG0488	(ABC) transporter
VC395_RS08235	COG3852	Histidine kinase
VC395_RS08240	COG2204	response regulator
VC395_RS08250	COG4662	Binding-protein-dependent transport system inner membrane component
VC395_RS08255	COG3842	ATPase activity
VC395_RS08260	COG0746	molybdenum cofactor guanylyltransferase activity
VC395_RS08290	COG1940	carbohydrate kinase activity
VC395_RS08295	COG3148	PFAM DTW domain containing protein
VC395_RS08305	COG0840	transmembrane signaling receptor activity
VC395_RS08310	COG0791	NLP P60 protein
VC395_RS08320	COG3001	Fructosamine kinase
VC395_RS08330	COG0534	Mate efflux family protein
VC395_RS08340	COG1793	dna ligase
VC395_RS08350	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VC395_RS08355	COG0848	biopolymer transport protein
VC395_RS08360	COG0811	peptide transport
VC395_RS08365	COG0811	peptide transport
VC395_RS08380	COG1175	transmembrane transport
VC395_RS08385	COG0395	ABC-type sugar transport system, permease component
VC395_RS08390	COG3842	ATPase activity
VC395_RS08395	COG1349	DNA-binding transcription factor activity
VC395_RS08400	COG0584	glycerophosphoryl diester phosphodiesterase
VC395_RS08405	COG2731	YhcH YjgK YiaL family protein
VC395_RS08410	COG0251	oxidation-reduction process
VC395_RS08415	COG1609	Transcriptional regulator
VC395_RS08420	COG2723	6-phospho-beta-galactosidase activity
VC395_RS08425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VC395_RS08430	COG0583	DNA-binding transcription factor activity
VC395_RS08450	COG0577	efflux transmembrane transporter activity
VC395_RS08450	COG1136	(ABC) transporter
VC395_RS08455	COG1136	(ABC) transporter
VC395_RS08455	COG0577	efflux transmembrane transporter activity
VC395_RS08460	COG1136	(ABC) transporter
VC395_RS08460	COG4591	ABC-type transport system involved in lipoprotein release permease component
VC395_RS08465	COG1294	oxidase, subunit
VC395_RS08470	COG1271	oxidase subunit
VC395_RS08495	COG3097	Belongs to the UPF0267 family
VC395_RS08510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VC395_RS08520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VC395_RS08540	COG0753	catalase activity
VC395_RS08555	COG3527	Alpha-acetolactate decarboxylase
VC395_RS08570	COG2200	EAL domain
VC395_RS08570	COG2199	diguanylate cyclase activity
VC395_RS08580	COG2017	converts alpha-aldose to the beta-anomer
VC395_RS08585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VC395_RS08590	COG1085	galactose-1-phosphate uridylyltransferase
VC395_RS08630	COG0835	chemotaxis
VC395_RS08630	COG0784	Response regulator, receiver
VC395_RS08640	COG4565	transcriptional regulatory protein
VC395_RS08645	COG3290	protein histidine kinase activity
VC395_RS08660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_RS08680	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VC395_RS08685	COG3063	Type IV pilus biogenesis stability protein PilW
VC395_RS08710	COG1451	nucleotide metabolic process
VC395_RS08720	COG0583	DNA-binding transcription factor activity
VC395_RS08740	COG1538	Outer membrane efflux protein
VC395_RS08755	COG1748	Saccharopine dehydrogenase
VC395_RS08765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VC395_RS08775	COG0577	efflux transmembrane transporter activity
VC395_RS08780	COG4181	ATPase activity
VC395_RS08785	COG0534	Mate efflux family protein
VC395_RS08790	COG0702	epimerase
VC395_RS08800	COG2814	Major facilitator Superfamily
VC395_RS08805	COG1187	pseudouridine synthase activity
VC395_RS08810	COG1061	Type III restriction enzyme res subunit
VC395_RS08830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VC395_RS08835	COG5001	Diguanylate cyclase
VC395_RS08835	COG2203	Gaf domain
VC395_RS08835	COG3706	GGDEF domain
VC395_RS08835	COG4251	negative regulation of phosphorylation
VC395_RS08850	COG0840	transmembrane signaling receptor activity
VC395_RS08895	COG2205	protein histidine kinase activity
VC395_RS08895	COG0784	Response regulator, receiver
VC395_RS08900	COG2239	Acts as a magnesium transporter
VC395_RS08910	COG0814	amino acid
VC395_RS08915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_RS08920	COG1131	(ABC) transporter
VC395_RS08925	COG0842	Transport permease protein
VC395_RS08935	COG3313	Fe-S protein
VC395_RS08945	COG4134	Bacterial extracellular solute-binding protein
VC395_RS08950	COG4135	transport system, permease component
VC395_RS08955	COG4136	ATPase activity
VC395_RS08960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VC395_RS08965	COG0564	pseudouridine synthase activity
VC395_RS08970	COG0733	neurotransmitter:sodium symporter activity
VC395_RS08980	COG0626	cystathionine gamma-synthase activity
VC395_RS08985	COG2818	Glycosylase
VC395_RS09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_RS09015	COG1842	Phage shock protein A
VC395_RS09020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VC395_RS09025	COG0747	negative chemotaxis
VC395_RS09030	COG4168	peptide transport system, permease
VC395_RS09045	COG4172	Belongs to the ABC transporter superfamily
VC395_RS09060	COG1227	inorganic diphosphatase activity
VC395_RS09080	COG0243	molybdopterin cofactor binding
VC395_RS09085	COG3005	denitrification pathway
VC395_RS09090	COG4459	periplasmic nitrate reductase
VC395_RS09100	COG2116	formate transmembrane transporter activity
VC395_RS09110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VC395_RS09115	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VC395_RS09125	COG2917	probably involved in intracellular septation
VC395_RS09130	COG1607	acyl-coa hydrolase
VC395_RS09135	COG2350	Protein conserved in bacteria
VC395_RS09145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VC395_RS09150	COG0583	DNA-binding transcription factor activity
VC395_RS09165	COG0612	Peptidase, M16
VC395_RS09170	COG5001	Diguanylate cyclase
VC395_RS09175	COG1032	radical SAM domain protein
VC395_RS09190	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VC395_RS09195	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VC395_RS09200	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VC395_RS09205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VC395_RS09210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VC395_RS09215	COG0745	RESPONSE REGULATOR receiver
VC395_RS09220	COG3381	protein complex oligomerization
VC395_RS09225	COG1609	Transcriptional regulator
VC395_RS09230	COG3070	regulator of competence-specific genes
VC395_RS09250	COG0297	glycogen (starch) synthase activity
VC395_RS09255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VC395_RS09260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VC395_RS09270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VC395_RS09280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VC395_RS09285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VC395_RS09290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VC395_RS09295	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VC395_RS09300	COG1960	acyl-CoA dehydrogenase activity
VC395_RS09320	COG1012	belongs to the aldehyde dehydrogenase family
VC395_RS09325	COG1309	transcriptional regulator
VC395_RS09350	COG0668	transmembrane transport
VC395_RS09355	COG2995	paraquat-inducible protein a
VC395_RS09360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VC395_RS09360	COG3008	intermembrane lipid transfer
VC395_RS09370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VC395_RS09385	COG0582	viral genome integration into host DNA
VC395_RS09395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VC395_RS09415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VC395_RS09435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VC395_RS09455	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VC395_RS09460	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VC395_RS09465	COG1737	Transcriptional regulator
VC395_RS09470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VC395_RS09475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VC395_RS09480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VC395_RS09485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VC395_RS09495	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VC395_RS09500	COG1940	carbohydrate kinase activity
VC395_RS09505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VC395_RS09510	COG4409	exo-alpha-(2->6)-sialidase activity
VC395_RS09520	COG2003	Belongs to the UPF0758 family
VC395_RS09540	COG3941	tape measure
VC395_RS09580	COG0488	(ABC) transporter
VC395_RS09655	COG0415	Belongs to the DNA photolyase family
VC395_RS09665	COG4628	conserved protein (DUF2132)
VC395_RS09670	COG3284	Transcriptional regulator
VC395_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
VC395_RS09685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_RS09690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_RS09695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_RS09705	COG2207	Transcriptional regulator
VC395_RS09710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_RS09710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_RS09710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VC395_RS09715	COG1482	cell wall glycoprotein biosynthetic process
VC395_RS09725	COG0784	Response regulator, receiver
VC395_RS09725	COG5002	protein histidine kinase activity
VC395_RS09735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VC395_RS09745	COG2885	chlorophyll binding
VC395_RS09750	COG0823	Involved in the tonB-independent uptake of proteins
VC395_RS09765	COG0811	peptide transport
VC395_RS09775	COG3790	cyd operon protein YbgE
VC395_RS09780	COG4890	Cyd operon protein YbgT
VC395_RS09785	COG1294	oxidase, subunit
VC395_RS09790	COG1271	oxidase subunit
VC395_RS09795	COG2255	four-way junction helicase activity
VC395_RS09800	COG0632	four-way junction helicase activity
VC395_RS09805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VC395_RS09810	COG0215	cysteine-tRNA ligase activity
VC395_RS09815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VC395_RS09820	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_RS09825	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VC395_RS09830	COG3012	SEC-C Motif Domain Protein
VC395_RS09835	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VC395_RS09840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VC395_RS09845	COG1199	ATP-dependent helicase activity
VC395_RS09850	COG0730	response to heat
VC395_RS09855	COG3923	Primosomal replication protein n
VC395_RS09865	COG0840	transmembrane signaling receptor activity
VC395_RS09870	COG0708	Exodeoxyribonuclease III
VC395_RS09875	COG4160	amino acid transport
VC395_RS09900	COG1882	Formate acetyltransferase
VC395_RS09910	COG0840	transmembrane signaling receptor activity
VC395_RS09915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VC395_RS09925	COG3013	Belongs to the UPF0304 family
VC395_RS09930	COG2766	serine protein kinase
VC395_RS09935	COG2718	Belongs to the UPF0229 family
VC395_RS09940	COG2719	SpoVR family
VC395_RS09945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VC395_RS09950	COG2835	tetraacyldisaccharide 4'-kinase activity
VC395_RS09955	COG1663	tetraacyldisaccharide 4'-kinase activity
VC395_RS09960	COG1132	(ABC) transporter
VC395_RS09965	COG0658	competence protein
VC395_RS09965	COG2333	competence protein COMEC
VC395_RS09975	COG4591	ABC-type transport system involved in lipoprotein release permease component
VC395_RS09980	COG1136	(ABC) transporter
VC395_RS09985	COG4591	ABC-type transport system involved in lipoprotein release permease component
VC395_RS09995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VC395_RS10015	COG1252	NADH dehydrogenase
VC395_RS10020	COG3150	esterase
VC395_RS10045	COG0537	adenosine 5'-monophosphoramidase activity
VC395_RS10060	COG2186	Transcriptional regulator
VC395_RS10065	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VC395_RS10070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VC395_RS10075	COG1674	ftsk spoiiie
VC395_RS10085	COG0686	Belongs to the AlaDH PNT family
VC395_RS10095	COG0583	DNA-binding transcription factor activity
VC395_RS10110	COG0284	orotidine-5'-phosphate decarboxylase activity
VC395_RS10115	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VC395_RS10120	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VC395_RS10125	COG0776	regulation of translation
VC395_RS10130	COG0539	negative regulation of cytoplasmic translation
VC395_RS10135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VC395_RS10140	COG1555	photosystem II stabilization
VC395_RS10145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VC395_RS10150	COG0776	regulation of translation
VC395_RS10155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VC395_RS10160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VC395_RS10170	COG0544	peptidyl-prolyl cis-trans isomerase activity
VC395_RS10180	COG4191	Histidine kinase
VC395_RS10190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VC395_RS10195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VC395_RS10200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VC395_RS10205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VC395_RS10220	COG3300	MHYT domain
VC395_RS10220	COG5001	Diguanylate cyclase
VC395_RS10230	COG4589	Belongs to the CDS family
VC395_RS10265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VC395_RS10275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_RS10290	COG0243	molybdopterin cofactor binding
VC395_RS10295	COG3005	denitrification pathway
VC395_RS10300	COG3325	Belongs to the glycosyl hydrolase 18 family
VC395_RS10300	COG3469	chitinase activity
VC395_RS10305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VC395_RS10315	COG2951	lytic endotransglycosylase activity
VC395_RS10320	COG3100	YcgL domain-containing protein
VC395_RS10325	COG0850	regulation of cytokinetic process
VC395_RS10330	COG2894	cell division
VC395_RS10335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VC395_RS10340	COG3015	lipoprotein NlpE involved in copper resistance
VC395_RS10360	COG0477	Major facilitator Superfamily
VC395_RS10370	COG0840	transmembrane signaling receptor activity
VC395_RS10375	COG1396	sequence-specific DNA binding
VC395_RS10380	COG3135	benzoate transporter
VC395_RS10400	COG0596	Alpha beta hydrolase
VC395_RS10405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VC395_RS10410	COG1169	isochorismate synthase
VC395_RS10415	COG0436	Aminotransferase
VC395_RS10420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VC395_RS10425	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VC395_RS10445	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VC395_RS10450	COG0318	PFAM AMP-dependent synthetase and ligase
VC395_RS10455	COG0596	Alpha beta hydrolase
VC395_RS10470	COG1214	PFAM Peptidase M22, glycoprotease
VC395_RS10475	COG1199	ATP-dependent helicase activity
VC395_RS10485	COG0788	formyltetrahydrofolate deformylase activity
VC395_RS10490	COG0446	pyridine nucleotide-disulphide oxidoreductase
VC395_RS10490	COG1902	pentaerythritol trinitrate reductase activity
VC395_RS10495	COG0616	signal peptide processing
VC395_RS10500	COG0252	asparaginase activity
VC395_RS10505	COG3139	Protein of unknown function (DUF1315)
VC395_RS10515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_RS10520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VC395_RS10525	COG0676	glucose-6-phosphate 1-epimerase activity
VC395_RS10535	COG2226	methyltransferase
VC395_RS10550	COG0784	Response regulator, receiver
VC395_RS10550	COG0835	chemotaxis
VC395_RS10555	COG1940	carbohydrate kinase activity
VC395_RS10565	COG4667	esterase of the alpha-beta hydrolase superfamily
VC395_RS10580	COG0733	neurotransmitter:sodium symporter activity
VC395_RS10585	COG1263	PTS System
VC395_RS10585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VC395_RS10590	COG0084	hydrolase, TatD family'
VC395_RS10600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VC395_RS10605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VC395_RS10610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VC395_RS10615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VC395_RS10620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VC395_RS10625	COG1028	Short-chain dehydrogenase reductase Sdr
VC395_RS10635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VC395_RS10640	COG0416	fatty acid biosynthetic process
VC395_RS10645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VC395_RS10650	COG1399	metal-binding, possibly nucleic acid-binding protein
VC395_RS10655	COG0424	maF-like protein
VC395_RS10660	COG0564	pseudouridine synthase activity
VC395_RS10675	COG1530	ribonuclease E activity
VC395_RS10680	COG0659	secondary active sulfate transmembrane transporter activity
VC395_RS10690	COG1012	belongs to the aldehyde dehydrogenase family
VC395_RS10690	COG1454	alcohol dehydrogenase
VC395_RS10695	COG2095	MarC family integral membrane protein
VC395_RS10700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VC395_RS10705	COG1757	Na H antiporter
VC395_RS10715	COG3081	Nucleoid-associated protein
VC395_RS10720	COG3082	Protein of unknown function (DUF1414)
VC395_RS10725	COG3083	sulfuric ester hydrolase activity
VC395_RS10740	COG0123	including yeast histone deacetylase and acetoin utilization protein
VC395_RS10745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VC395_RS10750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VC395_RS10770	COG2853	Lipoprotein
VC395_RS10780	COG4235	cytochrome complex assembly
VC395_RS10780	COG3088	subunit of a heme lyase
VC395_RS10785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VC395_RS10790	COG1138	Cytochrome C-type biogenesis protein
VC395_RS10795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VC395_RS10805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VC395_RS10810	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VC395_RS10815	COG4133	protoheme IX ABC transporter activity
VC395_RS10825	COG0835	chemotaxis
VC395_RS10835	COG1192	Involved in chromosome partitioning
VC395_RS10840	COG2201	protein-glutamate methylesterase activity
VC395_RS10845	COG2198	Histidine kinase
VC395_RS10845	COG0784	Response regulator, receiver
VC395_RS10845	COG0643	Histidine kinase
VC395_RS10850	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VC395_RS10880	COG2062	phosphohistidine phosphatase, SixA
VC395_RS10885	COG1025	Belongs to the peptidase M16 family
VC395_RS10895	COG0018	arginyl-trna synthetase
VC395_RS10915	COG1918	ferrous iron import across plasma membrane
VC395_RS10920	COG4977	sequence-specific DNA binding
VC395_RS10925	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VC395_RS10930	COG1121	(ABC) transporter
VC395_RS10935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VC395_RS10945	COG0045	succinate-CoA ligase (ADP-forming) activity
VC395_RS10950	COG0508	dehydrogenase complex catalyzes the overall conversion of
VC395_RS10955	COG0567	Dehydrogenase, E1 component
VC395_RS10965	COG1053	succinate dehydrogenase
VC395_RS10970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VC395_RS10975	COG2009	succinate dehydrogenase
VC395_RS10980	COG0372	Belongs to the citrate synthase family
VC395_RS10985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VC395_RS10995	COG0033	Phosphoglucomutase
VC395_RS11000	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VC395_RS11005	COG0596	Alpha beta hydrolase
VC395_RS11020	COG1346	cytolysis
VC395_RS11030	COG0583	DNA-binding transcription factor activity
VC395_RS11040	COG0735	belongs to the Fur family
VC395_RS11045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VC395_RS11050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VC395_RS11055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VC395_RS11060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VC395_RS11060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VC395_RS11065	COG0431	NADPH-dependent FMN reductase
VC395_RS11075	COG3101	peptidyl-lysine hydroxylation
VC395_RS11080	COG2860	membrane
VC395_RS11085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VC395_RS11095	COG2890	protein-(glutamine-N5) methyltransferase activity
VC395_RS11100	COG2840	Smr protein MutS2
VC395_RS11110	COG1684	flagellar biosynthetic protein fliR
VC395_RS11115	COG1987	bacterial-type flagellum assembly
VC395_RS11140	COG1580	Controls the rotational direction of flagella during chemotaxis
VC395_RS11160	COG1317	bacterial-type flagellum organization
VC395_RS11165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VC395_RS11175	COG1677	Flagellar hook-basal body complex protein FliE
VC395_RS11195	COG1516	flagellar protein fliS
VC395_RS11205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VC395_RS11210	COG1334	flagellar protein FlaG
VC395_RS11215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_RS11220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_RS11225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_RS11230	COG2837	iron assimilation
VC395_RS11250	COG1393	Belongs to the ArsC family
VC395_RS11255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VC395_RS11260	COG1876	peptidase activity
VC395_RS11270	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VC395_RS11275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VC395_RS11285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VC395_RS11305	COG4783	chaperone-mediated protein folding
VC395_RS11310	COG1393	Belongs to the ArsC family
VC395_RS11330	COG2233	PERMEase
VC395_RS11335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VC395_RS11340	COG0737	Belongs to the 5'-nucleotidase family
VC395_RS11345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VC395_RS11350	COG2912	Transglutaminase-like superfamily
VC395_RS11360	COG2890	protein-(glutamine-N5) methyltransferase activity
VC395_RS11365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VC395_RS11370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VC395_RS11375	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VC395_RS11380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VC395_RS11385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VC395_RS11390	COG0193	aminoacyl-tRNA hydrolase activity
VC395_RS11395	COG0012	GTP binding
VC395_RS11475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_RS11480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VC395_RS11500	COG1705	Flagellar rod assembly protein muramidase FlgJ
VC395_RS11500	COG3951	Flagellar rod assembly protein muramidase FlgJ
VC395_RS11505	COG1706	bacterial-type flagellum-dependent cell motility
VC395_RS11510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VC395_RS11520	COG4787	bacterial-type flagellum-dependent cell motility
VC395_RS11525	COG1749	Flagellar hook protein flgE
VC395_RS11540	COG1815	bacterial-type flagellum-dependent cell motility
VC395_RS11545	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VC395_RS11550	COG0835	chemotaxis
VC395_RS11550	COG0784	Response regulator, receiver
VC395_RS11585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VC395_RS11585	COG2226	methyltransferase
VC395_RS11585	COG3433	isochorismatase activity
VC395_RS11590	COG2375	cellular response to nickel ion
VC395_RS11595	COG1629	transport
VC395_RS11595	COG4774	siderophore transport
VC395_RS11610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VC395_RS11615	COG2608	mercury ion transmembrane transporter activity
VC395_RS11615	COG2217	Heavy metal translocating P-type atpase
VC395_RS11630	COG3735	TraB family
VC395_RS11645	COG2840	Smr protein MutS2
VC395_RS11650	COG1187	pseudouridine synthase activity
VC395_RS11660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VC395_RS11665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VC395_RS11670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VC395_RS11675	COG0121	glutamine amidotransferase
VC395_RS11680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VC395_RS11685	COG1960	acyl-CoA dehydrogenase activity
VC395_RS11700	COG0328	RNA-DNA hybrid ribonuclease activity
VC395_RS11705	COG2226	methyltransferase
VC395_RS11710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VC395_RS11715	COG1388	LysM domain
VC395_RS11715	COG0741	lytic transglycosylase activity
VC395_RS11720	COG3021	interspecies interaction between organisms
VC395_RS11725	COG0347	Belongs to the P(II) protein family
VC395_RS11730	COG3479	Phenolic acid decarboxylase
VC395_RS11740	COG0037	tRNA processing
VC395_RS11745	COG0825	malonyl-CoA metabolic process
VC395_RS11750	COG0587	DNA-directed DNA polymerase activity
VC395_RS11755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VC395_RS11760	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_RS11765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_RS11770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VC395_RS11775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VC395_RS11780	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VC395_RS11790	COG0750	zinc metalloprotease
VC395_RS11795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VC395_RS11800	COG0575	Belongs to the CDS family
VC395_RS11805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VC395_RS11810	COG0233	cytoplasmic translational termination
VC395_RS11815	COG0528	UMP kinase activity
VC395_RS11820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VC395_RS11825	COG0052	Belongs to the universal ribosomal protein uS2 family
VC395_RS11830	COG0024	Methionine aminopeptidase
VC395_RS11835	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VC395_RS11845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VC395_RS11850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VC395_RS11855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VC395_RS11860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VC395_RS11875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VC395_RS11875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VC395_RS11880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VC395_RS11885	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VC395_RS11890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VC395_RS11900	COG1073	alpha beta
VC395_RS11905	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VC395_RS11910	COG2252	PERMEase
VC395_RS11915	COG2195	Cleaves the N-terminal amino acid of tripeptides
VC395_RS11920	COG0189	ligase activity
VC395_RS11920	COG4067	protein conserved in archaea
VC395_RS11925	COG0189	ligase activity
VC395_RS11935	COG0733	neurotransmitter:sodium symporter activity
VC395_RS11940	COG3706	GGDEF domain
VC395_RS11950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VC395_RS11960	COG1477	protein flavinylation
VC395_RS11965	COG2871	sodium ion transport
VC395_RS11970	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_RS11975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_RS11980	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_RS11985	COG1805	sodium ion transport
VC395_RS11990	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VC395_RS11995	COG0271	Belongs to the BolA IbaG family
VC395_RS12000	COG2813	Specifically methylates the guanine in position
VC395_RS12010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VC395_RS12015	COG2211	Major facilitator Superfamily
VC395_RS12025	COG1595	DNA-templated transcription, initiation
VC395_RS12035	COG3248	Nucleoside-binding outer membrane protein
VC395_RS12040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VC395_RS12045	COG0693	protein deglycase activity
VC395_RS12050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VC395_RS12055	COG2166	iron-sulfur cluster assembly
VC395_RS12060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VC395_RS12065	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VC395_RS12075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VC395_RS12075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VC395_RS12090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VC395_RS12095	COG1074	ATP-dependent DNA helicase activity
VC395_RS12100	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VC395_RS12115	COG3141	response to X-ray
VC395_RS12120	COG2171	N-acyltransferase activity
VC395_RS12130	COG0456	acetyltransferase
VC395_RS12135	COG0189	ligase activity
VC395_RS12135	COG0569	domain protein
VC395_RS12150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VC395_RS12160	COG3250	beta-galactosidase activity
VC395_RS12175	COG1022	Amp-dependent synthetase and ligase
VC395_RS12180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VC395_RS12185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VC395_RS12195	COG0560	Phosphoserine phosphatase
VC395_RS12205	COG0813	purine-nucleoside phosphorylase activity
VC395_RS12210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VC395_RS12215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VC395_RS12220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VC395_RS12230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VC395_RS12235	COG0084	hydrolase, TatD family'
VC395_RS12240	COG3022	response to hydroperoxide
VC395_RS12245	COG1115	amino acid carrier protein
VC395_RS12260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VC395_RS12265	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VC395_RS12270	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VC395_RS12275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VC395_RS12280	COG0083	homoserine kinase activity
VC395_RS12295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VC395_RS12305	COG0745	RESPONSE REGULATOR receiver
VC395_RS12310	COG2198	Histidine kinase
VC395_RS12310	COG0784	Response regulator, receiver
VC395_RS12310	COG5002	protein histidine kinase activity
VC395_RS12315	COG3706	GGDEF domain
VC395_RS12315	COG2203	Gaf domain
VC395_RS12315	COG5001	Diguanylate cyclase
VC395_RS12315	COG4251	negative regulation of phosphorylation
VC395_RS12320	COG1242	4 iron, 4 sulfur cluster binding
VC395_RS12325	COG0069	glutamate synthase activity
VC395_RS12325	COG0067	glutamate synthase
VC395_RS12325	COG0070	glutamate synthase
VC395_RS12335	COG0070	glutamate synthase
VC395_RS12335	COG0069	glutamate synthase activity
VC395_RS12335	COG0067	glutamate synthase
VC395_RS12340	COG0493	'glutamate synthase
VC395_RS12350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VC395_RS12360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VC395_RS12365	COG2860	membrane
VC395_RS12370	COG0583	DNA-binding transcription factor activity
VC395_RS12375	COG0730	response to heat
VC395_RS12405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VC395_RS12410	COG0505	Belongs to the CarA family
VC395_RS12420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VC395_RS12425	COG0494	nUDIX hydrolase
VC395_RS12435	COG0653	protein targeting
VC395_RS12445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VC395_RS12450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VC395_RS12455	COG0849	cell division
VC395_RS12460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VC395_RS12465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VC395_RS12470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VC395_RS12475	COG0772	Belongs to the SEDS family
VC395_RS12480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VC395_RS12485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VC395_RS12490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VC395_RS12495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VC395_RS12500	COG0768	penicillin binding
VC395_RS12505	COG3116	cell division
VC395_RS12515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_RS12520	COG0508	dehydrogenase complex catalyzes the overall conversion of
VC395_RS12525	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VC395_RS12530	COG2186	Transcriptional regulator
VC395_RS12535	COG0737	Belongs to the 5'-nucleotidase family
VC395_RS12540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VC395_RS12545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VC395_RS12550	COG4974	Belongs to the 'phage' integrase family
VC395_RS12555	COG0716	FMN binding
VC395_RS12575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_RS12580	COG1459	type II secretion system
VC395_RS12590	COG0237	dephospho-CoA kinase activity
VC395_RS12595	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VC395_RS12605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VC395_RS12610	COG0187	DNA topoisomerase II activity
VC395_RS12615	COG3150	esterase
VC395_RS12625	COG3151	Protein conserved in bacteria
VC395_RS12630	COG0494	nUDIX hydrolase
VC395_RS12635	COG1538	Outer membrane efflux protein
VC395_RS12640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VC395_RS12640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VC395_RS12645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VC395_RS12650	COG0840	transmembrane signaling receptor activity
VC395_RS12655	COG3025	triphosphatase activity
VC395_RS12660	COG1392	Phosphate transport regulator
VC395_RS12665	COG0306	phosphate transporter
VC395_RS12670	COG4991	sh3 domain protein
VC395_RS12680	COG3267	Type II secretory pathway component ExeA
VC395_RS12680	COG3409	Peptidoglycan-binding domain 1 protein
VC395_RS12685	COG0617	tRNA 3'-terminal CCA addition
VC395_RS12690	COG0148	phosphopyruvate hydratase activity
VC395_RS12695	COG0504	CTP synthase activity
VC395_RS12700	COG3956	TIGRFAM MazG family protein
VC395_RS12705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VC395_RS12710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VC395_RS12735	COG0736	holo-[acyl-carrier-protein] synthase activity
VC395_RS12740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VC395_RS12745	COG1381	Involved in DNA repair and RecF pathway recombination
VC395_RS12750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VC395_RS12755	COG0571	ribonuclease III activity
VC395_RS12765	COG0481	GTPase activity
VC395_RS12770	COG3086	response to oxidative stress
VC395_RS12775	COG3026	antisigma factor binding
VC395_RS12785	COG1595	DNA-templated transcription, initiation
VC395_RS12795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VC395_RS12805	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VC395_RS12810	COG0354	folic acid binding
VC395_RS12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_RS12825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VC395_RS12830	COG3079	Belongs to the UPF0149 family
VC395_RS12835	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VC395_RS12840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VC395_RS12845	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VC395_RS12850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VC395_RS12855	COG0440	acetolactate synthase activity
VC395_RS12860	COG0028	Belongs to the TPP enzyme family
VC395_RS12865	COG1022	Amp-dependent synthetase and ligase
VC395_RS12870	COG0583	DNA-binding transcription factor activity
VC395_RS12895	COG0473	3-isopropylmalate dehydrogenase activity
VC395_RS12900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VC395_RS12905	COG0066	3-isopropylmalate dehydratase activity
VC395_RS12950	COG3437	response regulator, receiver
VC395_RS12965	COG0795	lipopolysaccharide-transporting ATPase activity
VC395_RS12970	COG0795	lipopolysaccharide-transporting ATPase activity
VC395_RS12975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VC395_RS12980	COG2927	DNA polymerase III (CHI subunit)
VC395_RS12985	COG0525	valine-tRNA ligase activity
VC395_RS12990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VC395_RS12995	COG0564	pseudouridine synthase activity
VC395_RS13000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VC395_RS13010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VC395_RS13020	COG0540	Belongs to the ATCase OTCase family
VC395_RS13025	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VC395_RS13030	COG0251	oxidation-reduction process
VC395_RS13040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VC395_RS13045	COG5007	Belongs to the BolA IbaG family
VC395_RS13055	COG2854	intermembrane phospholipid transfer
VC395_RS13060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VC395_RS13065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VC395_RS13070	COG1127	ABC transporter
VC395_RS13085	COG0517	IMP dehydrogenase activity
VC395_RS13085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VC395_RS13100	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VC395_RS13105	COG1137	ATPase activity
VC395_RS13115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VC395_RS13120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_RS13125	COG1660	Displays ATPase and GTPase activities
VC395_RS13130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VC395_RS13135	COG2239	Acts as a magnesium transporter
VC395_RS13140	COG0312	modulator of DNA gyrase
VC395_RS13145	COG3028	Belongs to the UPF0307 family
VC395_RS13150	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VC395_RS13155	COG1178	ABC-type Fe3 transport system permease component
VC395_RS13165	COG0163	prenyltransferase activity
VC395_RS13170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VC395_RS13180	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VC395_RS13185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VC395_RS13190	COG2105	PFAM AIG2 family protein
VC395_RS13200	COG0729	surface antigen
VC395_RS13205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VC395_RS13210	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VC395_RS13225	COG0577	efflux transmembrane transporter activity
VC395_RS13225	COG1136	(ABC) transporter
VC395_RS13245	COG0529	Catalyzes the synthesis of activated sulfate
VC395_RS13250	COG2895	sulfate adenylyltransferase (ATP) activity
VC395_RS13255	COG0175	sulfate reduction
VC395_RS13260	COG1648	precorrin-2 dehydrogenase activity
VC395_RS13260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VC395_RS13265	COG0737	Belongs to the 5'-nucleotidase family
VC395_RS13275	COG0513	Belongs to the DEAD box helicase family
VC395_RS13280	COG2153	protein acetylation
VC395_RS13285	COG0697	spore germination
VC395_RS13290	COG3061	Opacity-associated protein A
VC395_RS13290	COG3266	domain, Protein
VC395_RS13295	COG0545	Peptidyl-prolyl cis-trans isomerase
VC395_RS13310	COG0203	ribosomal protein L17
VC395_RS13315	COG0202	RNA polymerase activity
VC395_RS13320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VC395_RS13325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VC395_RS13330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VC395_RS13335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VC395_RS13340	COG0201	protein transport
VC395_RS13345	COG0200	Binds to the 23S rRNA
VC395_RS13350	COG1841	ribosomal large subunit assembly
VC395_RS13355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VC395_RS13360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VC395_RS13365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VC395_RS13370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VC395_RS13375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VC395_RS13380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VC395_RS13385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VC395_RS13390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VC395_RS13395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VC395_RS13400	COG0255	Belongs to the universal ribosomal protein uL29 family
VC395_RS13405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VC395_RS13410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VC395_RS13415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VC395_RS13420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VC395_RS13425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VC395_RS13430	COG0089	rRNA binding
VC395_RS13435	COG0088	Forms part of the polypeptide exit tunnel
VC395_RS13440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VC395_RS13445	COG0051	transcription antitermination factor activity, RNA binding
VC395_RS13450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VC395_RS13455	COG0557	exoribonuclease II activity
VC395_RS13460	COG3083	sulfuric ester hydrolase activity
VC395_RS13465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VC395_RS13470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VC395_RS13480	COG1047	Peptidyl-prolyl cis-trans
VC395_RS13495	COG2249	NAD(P)H dehydrogenase (quinone) activity
VC395_RS13500	COG0488	(ABC) transporter
VC395_RS13510	COG0429	hydrolase of the alpha beta-hydrolase fold
VC395_RS13520	COG3954	Phosphoribulokinase
VC395_RS13535	COG1012	belongs to the aldehyde dehydrogenase family
VC395_RS13545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VC395_RS13555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VC395_RS13570	COG0180	Tryptophanyl-tRNA synthetase
VC395_RS13575	COG0546	phosphoglycolate phosphatase activity
VC395_RS13580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VC395_RS13585	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VC395_RS13595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VC395_RS13600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VC395_RS13630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VC395_RS13640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VC395_RS13640	COG0678	peroxiredoxin activity
VC395_RS13645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VC395_RS13655	COG0165	Argininosuccinate lyase
VC395_RS13660	COG0137	argininosuccinate synthase activity
VC395_RS13665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VC395_RS13670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VC395_RS13675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VC395_RS13680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VC395_RS13690	COG1045	serine acetyltransferase
VC395_RS13695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VC395_RS13700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VC395_RS13705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VC395_RS13710	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VC395_RS13715	COG1053	succinate dehydrogenase
VC395_RS13720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VC395_RS13725	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VC395_RS13735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VC395_RS13740	COG1509	lysine 2,3-aminomutase activity
VC395_RS13750	COG0459	protein refolding
VC395_RS13755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VC395_RS13780	COG0149	triose-phosphate isomerase activity
VC395_RS13785	COG0534	Mate efflux family protein
VC395_RS13790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VC395_RS13795	COG1575	Belongs to the MenA family. Type 1 subfamily
VC395_RS13800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VC395_RS13805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VC395_RS13810	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VC395_RS13815	COG1609	Transcriptional regulator
VC395_RS13820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VC395_RS13825	COG0254	rRNA binding
VC395_RS13830	COG0281	malic enzyme
VC395_RS13835	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VC395_RS13840	COG0626	cystathionine gamma-synthase activity
VC395_RS13845	COG0460	homoserine dehydrogenase
VC395_RS13845	COG0527	aspartate kinase activity
VC395_RS13850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VC395_RS13855	COG3074	FtsZ-dependent cytokinesis
VC395_RS13860	COG1494	fructose-1,6-bisphosphatase
VC395_RS13865	COG0205	6-phosphofructokinase activity
VC395_RS13870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VC395_RS13880	COG0745	RESPONSE REGULATOR receiver
VC395_RS13885	COG2205	protein histidine kinase activity
VC395_RS13895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VC395_RS13900	COG3030	protein affecting phage T7 exclusion by the F plasmid
VC395_RS13905	COG3706	GGDEF domain
VC395_RS13910	COG1027	Aspartate ammonia-lyase
VC395_RS13915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VC395_RS13930	COG4232	protein-disulfide reductase activity
VC395_RS13940	COG3263	regulation of cellular component size
VC395_RS13950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VC395_RS13955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VC395_RS13960	COG0194	GDP metabolic process
VC395_RS13965	COG1758	RNA polymerase activity
VC395_RS13970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VC395_RS13975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VC395_RS13980	COG2233	PERMEase
VC395_RS13995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VC395_RS14000	COG2183	response to ionizing radiation
VC395_RS14010	COG0596	Alpha beta hydrolase
VC395_RS14015	COG1040	competence protein
VC395_RS14020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VC395_RS14020	COG0316	Belongs to the HesB IscA family
VC395_RS14025	COG0494	nUDIX hydrolase
VC395_RS14030	COG1218	3'(2'),5'-bisphosphate nucleotidase
VC395_RS14040	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VC395_RS14045	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VC395_RS14050	COG3156	type II secretion system protein K
VC395_RS14055	COG4795	General secretion pathway protein
VC395_RS14060	COG2165	general secretion pathway protein
VC395_RS14065	COG2165	general secretion pathway protein
VC395_RS14070	COG2165	general secretion pathway protein
VC395_RS14075	COG1459	type II secretion system
VC395_RS14080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VC395_RS14090	COG3031	protein transport across the cell outer membrane
VC395_RS14095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VC395_RS14100	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VC395_RS14105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VC395_RS14115	COG0456	acetyltransferase
VC395_RS14120	COG1490	D-aminoacyl-tRNA deacylase activity
VC395_RS14125	COG1295	ribonuclease BN
VC395_RS14135	COG1217	gtp-binding protein TYPA
VC395_RS14145	COG0174	glutamine synthetase
VC395_RS14155	COG3852	Histidine kinase
VC395_RS14165	COG5001	Diguanylate cyclase
VC395_RS14165	COG3300	MHYT domain
VC395_RS14170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VC395_RS14460	COG3072	Adenylate cyclase
VC395_RS14570	COG2937	Belongs to the GPAT DAPAT family
VC395_RS14605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VC395_RS14800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VC395_RS14905	COG0751	glycine-tRNA ligase activity
VC395_RS15010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VC395_RS15185	COG4166	transmembrane transport
VC395_RS15190	COG0747	negative chemotaxis
VC395_RS15210	COG0601	transmembrane transport
VC395_RS15310	COG0514	ATP-dependent DNA helicase (RecQ)
VC395_RS15340	COG4774	siderophore transport
VC395_RS15785	COG1857	crispr-associated protein
VC395_RS16015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VC395_RS16155	COG0085	RNA polymerase activity
VC395_RS16185	COG0085	RNA polymerase activity
VC395_RS16190	COG0085	RNA polymerase activity
VC395_RS16215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VC395_RS16360	COG0860	N-Acetylmuramoyl-L-alanine amidase
VC395_RS16460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VC395_RS16680	COG0646	methionine synthase
VC395_RS16680	COG1410	methionine synthase
VC395_RS16705	COG0646	methionine synthase
VC395_RS16705	COG1410	methionine synthase
VC395_RS16760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VC395_RS16900	COG3164	Protein of unknown function
VC395_RS17430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VC395_RS17545	COG0659	secondary active sulfate transmembrane transporter activity
VC395_RS17575	COG1489	DNA binding
VC395_RS17605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VC395_RS18145	COG5001	Diguanylate cyclase
VC395_RS18250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VC395_RS18380	COG0443	Heat shock 70 kDa protein
VC395_RS18410	COG1570	exodeoxyribonuclease VII activity
VC395_RS18830	COG3064	Membrane
VC395_RS18840	COG3064	Membrane
VC395_RS18875	COG0497	DNA recombination
VC395_RS19140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VC395_RS19460	COG0326	Molecular chaperone. Has ATPase activity
VC395_RS19475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VC395_RS19500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VC395_RS19610	COG4658	electron transport chain
VC395_RS19615	COG4656	Part of a membrane complex involved in electron transport