locus-tag	class	description
N4267_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N4267_RS00010	COG0592	DNA-directed DNA polymerase activity
N4267_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N4267_RS00020	COG0187	DNA topoisomerase II activity
N4267_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
N4267_RS00035	COG3977	Valine--pyruvate aminotransferase
N4267_RS00040	COG0751	glycine-tRNA ligase activity
N4267_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
N4267_RS00050	COG2119	membrane
N4267_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
N4267_RS00070	COG0604	alcohol dehydrogenase
N4267_RS00080	COG0129	dihydroxy-acid dehydratase activity
N4267_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N4267_RS00100	COG0606	chelatase, subunit chli
N4267_RS00105	COG0204	Acyl-transferase
N4267_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4267_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N4267_RS00125	COG3084	Protein conserved in bacteria
N4267_RS00130	COG4326	sporulation control protein
N4267_RS00135	COG1272	protein, Hemolysin III
N4267_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N4267_RS00150	COG0569	domain protein
N4267_RS00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N4267_RS00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N4267_RS00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N4267_RS00165	COG0242	peptide deformylase activity
N4267_RS00170	COG1652	LysM domain
N4267_RS00175	COG0758	DNA mediated transformation
N4267_RS00180	COG2922	Belongs to the Smg family
N4267_RS00185	COG0551	DNA topoisomerase type I activity
N4267_RS00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N4267_RS00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N4267_RS00200	COG0009	L-threonylcarbamoyladenylate synthase
N4267_RS00205	COG0408	coproporphyrinogen oxidase activity
N4267_RS00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N4267_RS00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N4267_RS00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N4267_RS00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N4267_RS00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N4267_RS00280	COG2104	thiamine diphosphate biosynthetic process
N4267_RS00285	COG2022	thiamine diphosphate biosynthetic process
N4267_RS00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N4267_RS00295	COG0006	proline dipeptidase activity
N4267_RS00295	COG0006	proline dipeptidase activity
N4267_RS00315	COG1522	sequence-specific DNA binding
N4267_RS00320	COG5001	Diguanylate cyclase
N4267_RS00320	COG5002	protein histidine kinase activity
N4267_RS00340	COG0589	response to stress
N4267_RS00345	COG1528	Iron-storage protein
N4267_RS00355	COG2081	HI0933 family
N4267_RS00365	COG1322	Protein conserved in bacteria
N4267_RS00370	COG2226	methyltransferase
N4267_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N4267_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N4267_RS00395	COG0805	protein transport
N4267_RS00400	COG1858	cytochrome C peroxidase
N4267_RS00405	COG0534	Mate efflux family protein
N4267_RS00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N4267_RS00420	COG2937	Belongs to the GPAT DAPAT family
N4267_RS00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N4267_RS00430	COG3161	chorismate lyase activity
N4267_RS00435	COG1580	Controls the rotational direction of flagella during chemotaxis
N4267_RS00440	COG0840	transmembrane signaling receptor activity
N4267_RS00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N4267_RS00455	COG0084	hydrolase, TatD family'
N4267_RS00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N4267_RS00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N4267_RS00490	COG3078	GTPase activator activity
N4267_RS00505	COG3071	HemY protein
N4267_RS00510	COG2959	enzyme of heme biosynthesis
N4267_RS00515	COG1587	Uroporphyrinogen-III synthase
N4267_RS00520	COG0181	hydroxymethylbilane synthase activity
N4267_RS00525	COG3072	Adenylate cyclase
N4267_RS00530	COG1965	Belongs to the frataxin family
N4267_RS00540	COG0019	diaminopimelate decarboxylase activity
N4267_RS00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N4267_RS00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N4267_RS00560	COG1011	Hydrolase
N4267_RS00565	COG2199	diguanylate cyclase activity
N4267_RS00565	COG3287	FIST C domain
N4267_RS00565	COG2200	EAL domain
N4267_RS00580	COG0561	phosphatase activity
N4267_RS00585	COG2267	carboxylic ester hydrolase activity
N4267_RS00590	COG1280	lysine exporter protein (LysE YggA)
N4267_RS00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N4267_RS00600	COG0783	Belongs to the Dps family
N4267_RS00630	COG0742	ribosomal rna small subunit methyltransferase
N4267_RS00635	COG0552	protein localization to endoplasmic reticulum
N4267_RS00640	COG2884	Cell division ATP-binding protein ftsE
N4267_RS00645	COG2177	Part of the ABC transporter FtsEX involved in
N4267_RS00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N4267_RS00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4267_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N4267_RS00680	COG1404	Belongs to the peptidase S8 family
N4267_RS00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N4267_RS00730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N4267_RS00735	COG5001	Diguanylate cyclase
N4267_RS00735	COG3300	MHYT domain
N4267_RS00745	COG3852	Histidine kinase
N4267_RS00755	COG0174	glutamine synthetase
N4267_RS00765	COG1217	gtp-binding protein TYPA
N4267_RS00775	COG1295	ribonuclease BN
N4267_RS00780	COG1490	D-aminoacyl-tRNA deacylase activity
N4267_RS00785	COG0456	acetyltransferase
N4267_RS00795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N4267_RS00800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N4267_RS00805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N4267_RS00810	COG3031	protein transport across the cell outer membrane
N4267_RS00820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4267_RS00825	COG1459	type II secretion system
N4267_RS00830	COG2165	general secretion pathway protein
N4267_RS00835	COG2165	general secretion pathway protein
N4267_RS00840	COG2165	general secretion pathway protein
N4267_RS00845	COG4795	General secretion pathway protein
N4267_RS00850	COG3156	type II secretion system protein K
N4267_RS00855	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N4267_RS00860	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N4267_RS00870	COG1218	3'(2'),5'-bisphosphate nucleotidase
N4267_RS00875	COG0494	nUDIX hydrolase
N4267_RS00885	COG1040	competence protein
N4267_RS00895	COG0596	Alpha beta hydrolase
N4267_RS00905	COG2183	response to ionizing radiation
N4267_RS00910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N4267_RS00915	COG2199	diguanylate cyclase activity
N4267_RS00930	COG2233	PERMEase
N4267_RS00935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N4267_RS00940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4267_RS00945	COG1758	RNA polymerase activity
N4267_RS00950	COG0194	GDP metabolic process
N4267_RS00955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N4267_RS00960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4267_RS00980	COG4232	protein-disulfide reductase activity
N4267_RS00990	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N4267_RS00995	COG1027	Aspartate ammonia-lyase
N4267_RS01000	COG3706	GGDEF domain
N4267_RS01005	COG3030	protein affecting phage T7 exclusion by the F plasmid
N4267_RS01010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N4267_RS01020	COG2205	protein histidine kinase activity
N4267_RS01025	COG0745	RESPONSE REGULATOR receiver
N4267_RS01035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N4267_RS01040	COG0205	6-phosphofructokinase activity
N4267_RS01045	COG1494	fructose-1,6-bisphosphatase
N4267_RS01050	COG3074	FtsZ-dependent cytokinesis
N4267_RS01055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N4267_RS01060	COG0527	aspartate kinase activity
N4267_RS01060	COG0460	homoserine dehydrogenase
N4267_RS01065	COG0626	cystathionine gamma-synthase activity
N4267_RS01070	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
N4267_RS01075	COG0281	malic enzyme
N4267_RS01080	COG0254	rRNA binding
N4267_RS01085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N4267_RS01090	COG1609	Transcriptional regulator
N4267_RS01095	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N4267_RS01100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N4267_RS01105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N4267_RS01110	COG1575	Belongs to the MenA family. Type 1 subfamily
N4267_RS01115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N4267_RS01120	COG0534	Mate efflux family protein
N4267_RS01125	COG0149	triose-phosphate isomerase activity
N4267_RS01150	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N4267_RS01155	COG0459	protein refolding
N4267_RS01165	COG1509	lysine 2,3-aminomutase activity
N4267_RS01170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N4267_RS01180	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N4267_RS01185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N4267_RS01190	COG1053	succinate dehydrogenase
N4267_RS01195	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N4267_RS01200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N4267_RS01205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N4267_RS01210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N4267_RS01215	COG1045	serine acetyltransferase
N4267_RS01225	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N4267_RS01230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N4267_RS01235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N4267_RS01240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N4267_RS01245	COG0137	argininosuccinate synthase activity
N4267_RS01250	COG0165	Argininosuccinate lyase
N4267_RS01260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4267_RS01265	COG0678	peroxiredoxin activity
N4267_RS01265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N4267_RS01275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N4267_RS01305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N4267_RS01310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N4267_RS01320	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N4267_RS01325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N4267_RS01330	COG0546	phosphoglycolate phosphatase activity
N4267_RS01335	COG0180	Tryptophanyl-tRNA synthetase
N4267_RS01350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N4267_RS01360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N4267_RS01370	COG1012	belongs to the aldehyde dehydrogenase family
N4267_RS01385	COG3954	Phosphoribulokinase
N4267_RS01395	COG0429	hydrolase of the alpha beta-hydrolase fold
N4267_RS01405	COG0488	(ABC) transporter
N4267_RS01410	COG2249	NAD(P)H dehydrogenase (quinone) activity
N4267_RS01425	COG1047	Peptidyl-prolyl cis-trans
N4267_RS01435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N4267_RS01440	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N4267_RS01445	COG3083	sulfuric ester hydrolase activity
N4267_RS01450	COG0557	exoribonuclease II activity
N4267_RS01455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4267_RS01460	COG0051	transcription antitermination factor activity, RNA binding
N4267_RS01465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N4267_RS01470	COG0088	Forms part of the polypeptide exit tunnel
N4267_RS01475	COG0089	rRNA binding
N4267_RS01480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N4267_RS01485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N4267_RS01490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N4267_RS01495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N4267_RS01500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N4267_RS01505	COG0255	Belongs to the universal ribosomal protein uL29 family
N4267_RS01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N4267_RS01515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N4267_RS01520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N4267_RS01525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N4267_RS01530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N4267_RS01535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N4267_RS01540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N4267_RS01545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N4267_RS01550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N4267_RS01555	COG1841	ribosomal large subunit assembly
N4267_RS01565	COG0201	protein transport
N4267_RS01570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N4267_RS01575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N4267_RS01580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N4267_RS01585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N4267_RS01590	COG0202	RNA polymerase activity
N4267_RS01595	COG0203	ribosomal protein L17
N4267_RS01605	COG0545	Peptidyl-prolyl cis-trans isomerase
N4267_RS01610	COG3266	domain, Protein
N4267_RS01610	COG3061	Opacity-associated protein A
N4267_RS01615	COG0697	spore germination
N4267_RS01620	COG2153	protein acetylation
N4267_RS01625	COG0513	Belongs to the DEAD box helicase family
N4267_RS01640	COG1648	precorrin-2 dehydrogenase activity
N4267_RS01640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N4267_RS01650	COG2895	sulfate adenylyltransferase (ATP) activity
N4267_RS01655	COG0529	Catalyzes the synthesis of activated sulfate
N4267_RS01675	COG1136	(ABC) transporter
N4267_RS01690	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N4267_RS01695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4267_RS01700	COG0729	surface antigen
N4267_RS01710	COG2105	PFAM AIG2 family protein
N4267_RS01715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N4267_RS01725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N4267_RS01730	COG0163	prenyltransferase activity
N4267_RS01740	COG1178	ABC-type Fe3 transport system permease component
N4267_RS01745	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N4267_RS01750	COG3028	Belongs to the UPF0307 family
N4267_RS01755	COG0312	modulator of DNA gyrase
N4267_RS01760	COG2239	Acts as a magnesium transporter
N4267_RS01765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4267_RS01770	COG1660	Displays ATPase and GTPase activities
N4267_RS01775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4267_RS01780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N4267_RS01790	COG1137	ATPase activity
N4267_RS01795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N4267_RS01810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N4267_RS01810	COG0517	IMP dehydrogenase activity
N4267_RS01820	COG1127	ABC transporter
N4267_RS01825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N4267_RS01830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N4267_RS01835	COG2854	intermembrane phospholipid transfer
N4267_RS01845	COG5007	Belongs to the BolA IbaG family
N4267_RS01850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N4267_RS01860	COG0251	oxidation-reduction process
N4267_RS01870	COG0540	Belongs to the ATCase OTCase family
N4267_RS01880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N4267_RS01885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N4267_RS01890	COG0564	pseudouridine synthase activity
N4267_RS01895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N4267_RS01900	COG0525	valine-tRNA ligase activity
N4267_RS01905	COG2927	DNA polymerase III (CHI subunit)
N4267_RS01910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N4267_RS01915	COG0795	lipopolysaccharide-transporting ATPase activity
N4267_RS01920	COG0795	lipopolysaccharide-transporting ATPase activity
N4267_RS01935	COG3437	response regulator, receiver
N4267_RS01975	COG0066	3-isopropylmalate dehydratase activity
N4267_RS01980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N4267_RS01985	COG0473	3-isopropylmalate dehydrogenase activity
N4267_RS02005	COG0583	DNA-binding transcription factor activity
N4267_RS02010	COG1022	Amp-dependent synthetase and ligase
N4267_RS02015	COG0028	Belongs to the TPP enzyme family
N4267_RS02020	COG0440	acetolactate synthase activity
N4267_RS02025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N4267_RS02030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N4267_RS02035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N4267_RS02045	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N4267_RS02050	COG3079	Belongs to the UPF0149 family
N4267_RS02055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4267_RS02060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4267_RS02070	COG0354	folic acid binding
N4267_RS02075	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N4267_RS02085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N4267_RS02090	COG1595	DNA-templated transcription, initiation
N4267_RS02100	COG3026	antisigma factor binding
N4267_RS02105	COG3086	response to oxidative stress
N4267_RS02110	COG0481	GTPase activity
N4267_RS02120	COG0571	ribonuclease III activity
N4267_RS02125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N4267_RS02130	COG1381	Involved in DNA repair and RecF pathway recombination
N4267_RS02135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N4267_RS02170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N4267_RS02175	COG3956	TIGRFAM MazG family protein
N4267_RS02180	COG0504	CTP synthase activity
N4267_RS02185	COG0148	phosphopyruvate hydratase activity
N4267_RS02190	COG0617	tRNA 3'-terminal CCA addition
N4267_RS02195	COG3267	Type II secretory pathway component ExeA
N4267_RS02195	COG3409	Peptidoglycan-binding domain 1 protein
N4267_RS02205	COG4991	sh3 domain protein
N4267_RS02210	COG0306	phosphate transporter
N4267_RS02215	COG1392	Phosphate transport regulator
N4267_RS02220	COG3025	triphosphatase activity
N4267_RS02225	COG0840	transmembrane signaling receptor activity
N4267_RS02230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N4267_RS02235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N4267_RS02235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N4267_RS02240	COG1538	Outer membrane efflux protein
N4267_RS02245	COG0494	nUDIX hydrolase
N4267_RS02250	COG3151	Protein conserved in bacteria
N4267_RS02260	COG3150	esterase
N4267_RS02265	COG0187	DNA topoisomerase II activity
N4267_RS02270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N4267_RS02280	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
N4267_RS02285	COG0237	dephospho-CoA kinase activity
N4267_RS02295	COG1459	type II secretion system
N4267_RS02300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4267_RS02305	COG4969	Belongs to the N-Me-Phe pilin family
N4267_RS02310	COG0157	Belongs to the NadC ModD family
N4267_RS02325	COG0716	FMN binding
N4267_RS02330	COG4974	Belongs to the 'phage' integrase family
N4267_RS02335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4267_RS02340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N4267_RS02345	COG2186	Transcriptional regulator
N4267_RS02350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N4267_RS02355	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4267_RS02360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4267_RS02375	COG3116	cell division
N4267_RS02380	COG0768	penicillin binding
N4267_RS02385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N4267_RS02390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N4267_RS02400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N4267_RS02405	COG0772	Belongs to the SEDS family
N4267_RS02415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N4267_RS02420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N4267_RS02425	COG0849	cell division
N4267_RS02430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N4267_RS02435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N4267_RS02445	COG0653	protein targeting
N4267_RS02450	COG0494	nUDIX hydrolase
N4267_RS02455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N4267_RS02465	COG0505	Belongs to the CarA family
N4267_RS02470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N4267_RS02490	COG0730	response to heat
N4267_RS02495	COG0583	DNA-binding transcription factor activity
N4267_RS02500	COG2860	membrane
N4267_RS02505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N4267_RS02515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N4267_RS02525	COG0493	'glutamate synthase
N4267_RS02530	COG0067	glutamate synthase
N4267_RS02530	COG0070	glutamate synthase
N4267_RS02530	COG0069	glutamate synthase activity
N4267_RS02540	COG0070	glutamate synthase
N4267_RS02540	COG0069	glutamate synthase activity
N4267_RS02540	COG0067	glutamate synthase
N4267_RS02545	COG1242	4 iron, 4 sulfur cluster binding
N4267_RS02550	COG3706	GGDEF domain
N4267_RS02550	COG5001	Diguanylate cyclase
N4267_RS02550	COG2203	Gaf domain
N4267_RS02550	COG4251	negative regulation of phosphorylation
N4267_RS02555	COG2198	Histidine kinase
N4267_RS02555	COG5002	protein histidine kinase activity
N4267_RS02555	COG0784	Response regulator, receiver
N4267_RS02560	COG0745	RESPONSE REGULATOR receiver
N4267_RS02570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N4267_RS02590	COG0083	homoserine kinase activity
N4267_RS02595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N4267_RS02600	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
N4267_RS02605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N4267_RS02615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N4267_RS02630	COG1115	amino acid carrier protein
N4267_RS02635	COG3022	response to hydroperoxide
N4267_RS02645	COG0084	hydrolase, TatD family'
N4267_RS02650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N4267_RS02660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N4267_RS02665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N4267_RS02670	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N4267_RS02685	COG0560	Phosphoserine phosphatase
N4267_RS02695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N4267_RS02700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N4267_RS02705	COG1022	Amp-dependent synthetase and ligase
N4267_RS02720	COG3250	beta-galactosidase activity
N4267_RS02725	COG1609	Transcriptional regulator
N4267_RS02730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4267_RS02745	COG0189	ligase activity
N4267_RS02745	COG0569	domain protein
N4267_RS02750	COG0456	acetyltransferase
N4267_RS02760	COG2171	N-acyltransferase activity
N4267_RS02765	COG3141	response to X-ray
N4267_RS02780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N4267_RS02785	COG1074	ATP-dependent DNA helicase activity
N4267_RS02790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N4267_RS02800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N4267_RS02800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N4267_RS02810	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N4267_RS02815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N4267_RS02820	COG2166	iron-sulfur cluster assembly
N4267_RS02825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N4267_RS02830	COG0693	protein deglycase activity
N4267_RS02835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N4267_RS02850	COG1595	DNA-templated transcription, initiation
N4267_RS02860	COG2211	Major facilitator Superfamily
N4267_RS02865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N4267_RS02875	COG2813	Specifically methylates the guanine in position
N4267_RS02880	COG0271	Belongs to the BolA IbaG family
N4267_RS02885	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N4267_RS02890	COG1805	sodium ion transport
N4267_RS02895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N4267_RS02900	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N4267_RS02905	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N4267_RS02910	COG2871	sodium ion transport
N4267_RS02915	COG1477	protein flavinylation
N4267_RS02935	COG3706	GGDEF domain
N4267_RS02940	COG0733	neurotransmitter:sodium symporter activity
N4267_RS02950	COG0189	ligase activity
N4267_RS02955	COG0189	ligase activity
N4267_RS02955	COG4067	protein conserved in archaea
N4267_RS02960	COG2195	Cleaves the N-terminal amino acid of tripeptides
N4267_RS02965	COG2252	PERMEase
N4267_RS02970	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N4267_RS02975	COG1073	alpha beta
N4267_RS02985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N4267_RS02990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N4267_RS02995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N4267_RS03000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4267_RS03000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4267_RS03015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N4267_RS03020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N4267_RS03025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N4267_RS03030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N4267_RS03040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N4267_RS03045	COG0024	Methionine aminopeptidase
N4267_RS03050	COG0052	Belongs to the universal ribosomal protein uS2 family
N4267_RS03055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N4267_RS03060	COG0528	UMP kinase activity
N4267_RS03065	COG0233	cytoplasmic translational termination
N4267_RS03070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N4267_RS03075	COG0575	Belongs to the CDS family
N4267_RS03080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N4267_RS03085	COG0750	zinc metalloprotease
N4267_RS03095	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N4267_RS03100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4267_RS03105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N4267_RS03110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4267_RS03115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4267_RS03120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N4267_RS03125	COG0587	DNA-directed DNA polymerase activity
N4267_RS03130	COG0825	malonyl-CoA metabolic process
N4267_RS03140	COG0037	tRNA processing
N4267_RS03150	COG3479	Phenolic acid decarboxylase
N4267_RS03155	COG0347	Belongs to the P(II) protein family
N4267_RS03160	COG3021	interspecies interaction between organisms
N4267_RS03165	COG1388	LysM domain
N4267_RS03165	COG0741	lytic transglycosylase activity
N4267_RS03170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4267_RS03175	COG2226	methyltransferase
N4267_RS03180	COG0328	RNA-DNA hybrid ribonuclease activity
N4267_RS03195	COG1960	acyl-CoA dehydrogenase activity
N4267_RS03200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N4267_RS03205	COG0121	glutamine amidotransferase
N4267_RS03210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N4267_RS03215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N4267_RS03220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N4267_RS03230	COG1187	pseudouridine synthase activity
N4267_RS03235	COG2840	Smr protein MutS2
N4267_RS03250	COG3735	TraB family
N4267_RS03265	COG2217	Heavy metal translocating P-type atpase
N4267_RS03265	COG2608	mercury ion transmembrane transporter activity
N4267_RS03270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N4267_RS03285	COG1629	transport
N4267_RS03285	COG4774	siderophore transport
N4267_RS03290	COG2375	cellular response to nickel ion
N4267_RS03295	COG3433	isochorismatase activity
N4267_RS03295	COG2226	methyltransferase
N4267_RS03295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4267_RS03330	COG0835	chemotaxis
N4267_RS03330	COG0784	Response regulator, receiver
N4267_RS03335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N4267_RS03340	COG1815	bacterial-type flagellum-dependent cell motility
N4267_RS03355	COG1749	Flagellar hook protein flgE
N4267_RS03360	COG4787	bacterial-type flagellum-dependent cell motility
N4267_RS03370	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N4267_RS03375	COG1706	bacterial-type flagellum-dependent cell motility
N4267_RS03380	COG3951	Flagellar rod assembly protein muramidase FlgJ
N4267_RS03380	COG1705	Flagellar rod assembly protein muramidase FlgJ
N4267_RS03395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N4267_RS03400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N4267_RS03485	COG0012	GTP binding
N4267_RS03490	COG0193	aminoacyl-tRNA hydrolase activity
N4267_RS03495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N4267_RS03500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N4267_RS03505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N4267_RS03510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N4267_RS03515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N4267_RS03520	COG2890	protein-(glutamine-N5) methyltransferase activity
N4267_RS03530	COG2912	Transglutaminase-like superfamily
N4267_RS03535	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N4267_RS03540	COG0737	Belongs to the 5'-nucleotidase family
N4267_RS03545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N4267_RS03550	COG2233	PERMEase
N4267_RS03570	COG1393	Belongs to the ArsC family
N4267_RS03575	COG4783	chaperone-mediated protein folding
N4267_RS03595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N4267_RS03610	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
N4267_RS03625	COG1876	peptidase activity
N4267_RS03635	COG1393	Belongs to the ArsC family
N4267_RS03655	COG2837	iron assimilation
N4267_RS03660	COG2706	6-phosphogluconolactonase activity
N4267_RS03670	COG0800	Aldolase
N4267_RS03680	COG4145	pantothenate transmembrane transporter activity
N4267_RS03690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N4267_RS03700	COG1737	Transcriptional regulator
N4267_RS03700	COG0837	glucose binding
N4267_RS03705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N4267_RS03710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N4267_RS03715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N4267_RS03720	COG1334	flagellar protein FlaG
N4267_RS03725	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N4267_RS03735	COG1516	flagellar protein fliS
N4267_RS03755	COG1677	Flagellar hook-basal body complex protein FliE
N4267_RS03765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N4267_RS03770	COG1317	bacterial-type flagellum organization
N4267_RS03795	COG1580	Controls the rotational direction of flagella during chemotaxis
N4267_RS03820	COG1987	bacterial-type flagellum assembly
N4267_RS03825	COG1684	flagellar biosynthetic protein fliR
N4267_RS03835	COG2840	Smr protein MutS2
N4267_RS03840	COG2890	protein-(glutamine-N5) methyltransferase activity
N4267_RS03845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N4267_RS03850	COG2860	membrane
N4267_RS03855	COG3101	peptidyl-lysine hydroxylation
N4267_RS03865	COG0431	NADPH-dependent FMN reductase
N4267_RS03870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N4267_RS03870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N4267_RS03875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N4267_RS03880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N4267_RS03885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N4267_RS03890	COG0735	belongs to the Fur family
N4267_RS03900	COG0583	DNA-binding transcription factor activity
N4267_RS03910	COG1346	cytolysis
N4267_RS03925	COG0596	Alpha beta hydrolase
N4267_RS03930	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N4267_RS03935	COG0033	Phosphoglucomutase
N4267_RS03945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N4267_RS03950	COG0372	Belongs to the citrate synthase family
N4267_RS03955	COG2009	succinate dehydrogenase
N4267_RS03960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N4267_RS03965	COG1053	succinate dehydrogenase
N4267_RS03975	COG0567	Dehydrogenase, E1 component
N4267_RS03980	COG0508	dehydrogenase complex catalyzes the overall conversion of
N4267_RS03985	COG0045	succinate-CoA ligase (ADP-forming) activity
N4267_RS03995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N4267_RS04000	COG1121	(ABC) transporter
N4267_RS04005	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N4267_RS04010	COG4977	sequence-specific DNA binding
N4267_RS04015	COG1918	ferrous iron import across plasma membrane
N4267_RS04035	COG0018	arginyl-trna synthetase
N4267_RS04045	COG1025	Belongs to the peptidase M16 family
N4267_RS04050	COG2062	phosphohistidine phosphatase, SixA
N4267_RS04080	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N4267_RS04085	COG0784	Response regulator, receiver
N4267_RS04085	COG2198	Histidine kinase
N4267_RS04085	COG0643	Histidine kinase
N4267_RS04090	COG2201	protein-glutamate methylesterase activity
N4267_RS04095	COG1192	Involved in chromosome partitioning
N4267_RS04105	COG0835	chemotaxis
N4267_RS04115	COG4133	protoheme IX ABC transporter activity
N4267_RS04120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N4267_RS04125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N4267_RS04135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N4267_RS04140	COG1138	Cytochrome C-type biogenesis protein
N4267_RS04145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N4267_RS04150	COG3088	subunit of a heme lyase
N4267_RS04150	COG4235	cytochrome complex assembly
N4267_RS04160	COG2853	Lipoprotein
N4267_RS04180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N4267_RS04185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N4267_RS04190	COG0123	including yeast histone deacetylase and acetoin utilization protein
N4267_RS04205	COG3083	sulfuric ester hydrolase activity
N4267_RS04210	COG3082	Protein of unknown function (DUF1414)
N4267_RS04215	COG3081	Nucleoid-associated protein
N4267_RS04225	COG1757	Na H antiporter
N4267_RS04230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N4267_RS04235	COG2095	MarC family integral membrane protein
N4267_RS04240	COG1012	belongs to the aldehyde dehydrogenase family
N4267_RS04240	COG1454	alcohol dehydrogenase
N4267_RS04250	COG0659	secondary active sulfate transmembrane transporter activity
N4267_RS04255	COG1530	ribonuclease E activity
N4267_RS04260	COG0564	pseudouridine synthase activity
N4267_RS04265	COG0424	maF-like protein
N4267_RS04270	COG1399	metal-binding, possibly nucleic acid-binding protein
N4267_RS04275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N4267_RS04280	COG0416	fatty acid biosynthetic process
N4267_RS04285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N4267_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
N4267_RS04300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N4267_RS04305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N4267_RS04310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N4267_RS04315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N4267_RS04320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N4267_RS04330	COG0084	hydrolase, TatD family'
N4267_RS04335	COG1263	PTS System
N4267_RS04335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4267_RS04345	COG0733	neurotransmitter:sodium symporter activity
N4267_RS04360	COG4667	esterase of the alpha-beta hydrolase superfamily
N4267_RS04370	COG1940	carbohydrate kinase activity
N4267_RS04375	COG0784	Response regulator, receiver
N4267_RS04375	COG0835	chemotaxis
N4267_RS04390	COG2226	methyltransferase
N4267_RS04400	COG0676	glucose-6-phosphate 1-epimerase activity
N4267_RS04405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N4267_RS04410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4267_RS04420	COG3139	Protein of unknown function (DUF1315)
N4267_RS04425	COG0252	asparaginase activity
N4267_RS04430	COG0616	signal peptide processing
N4267_RS04435	COG0446	pyridine nucleotide-disulphide oxidoreductase
N4267_RS04435	COG1902	pentaerythritol trinitrate reductase activity
N4267_RS04440	COG0788	formyltetrahydrofolate deformylase activity
N4267_RS04450	COG1199	ATP-dependent helicase activity
N4267_RS04455	COG1214	PFAM Peptidase M22, glycoprotease
N4267_RS04470	COG0596	Alpha beta hydrolase
N4267_RS04475	COG0318	PFAM AMP-dependent synthetase and ligase
N4267_RS04480	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N4267_RS04495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N4267_RS04500	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N4267_RS04505	COG0436	Aminotransferase
N4267_RS04510	COG1169	isochorismate synthase
N4267_RS04515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N4267_RS04520	COG0596	Alpha beta hydrolase
N4267_RS04540	COG3135	benzoate transporter
N4267_RS04565	COG3015	lipoprotein NlpE involved in copper resistance
N4267_RS04570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N4267_RS04575	COG2894	cell division
N4267_RS04580	COG0850	regulation of cytokinetic process
N4267_RS04585	COG3100	YcgL domain-containing protein
N4267_RS04590	COG2951	lytic endotransglycosylase activity
N4267_RS04600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N4267_RS04605	COG3005	denitrification pathway
N4267_RS04610	COG0243	molybdopterin cofactor binding
N4267_RS04625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4267_RS04640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N4267_RS04680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N4267_RS04685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N4267_RS04690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N4267_RS04695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N4267_RS04705	COG4191	Histidine kinase
N4267_RS04715	COG0544	peptidyl-prolyl cis-trans isomerase activity
N4267_RS04725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N4267_RS04730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N4267_RS04735	COG0776	regulation of translation
N4267_RS04740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4267_RS04745	COG1555	photosystem II stabilization
N4267_RS04750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N4267_RS04755	COG0539	negative regulation of cytoplasmic translation
N4267_RS04760	COG0776	regulation of translation
N4267_RS04765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N4267_RS04770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N4267_RS04790	COG0583	DNA-binding transcription factor activity
N4267_RS04800	COG0686	Belongs to the AlaDH PNT family
N4267_RS04810	COG1674	ftsk spoiiie
N4267_RS04815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N4267_RS04820	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N4267_RS04825	COG2186	Transcriptional regulator
N4267_RS04840	COG0537	adenosine 5'-monophosphoramidase activity
N4267_RS04865	COG3150	esterase
N4267_RS04870	COG1252	NADH dehydrogenase
N4267_RS04895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N4267_RS04905	COG4591	ABC-type transport system involved in lipoprotein release permease component
N4267_RS04910	COG1136	(ABC) transporter
N4267_RS04915	COG4591	ABC-type transport system involved in lipoprotein release permease component
N4267_RS04925	COG2333	competence protein COMEC
N4267_RS04925	COG0658	competence protein
N4267_RS04930	COG1132	(ABC) transporter
N4267_RS04935	COG1663	tetraacyldisaccharide 4'-kinase activity
N4267_RS04940	COG2835	tetraacyldisaccharide 4'-kinase activity
N4267_RS04945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N4267_RS04950	COG2719	SpoVR family
N4267_RS04955	COG2718	Belongs to the UPF0229 family
N4267_RS04960	COG2766	serine protein kinase
N4267_RS04965	COG3013	Belongs to the UPF0304 family
N4267_RS04975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N4267_RS04980	COG0840	transmembrane signaling receptor activity
N4267_RS04990	COG1882	Formate acetyltransferase
N4267_RS05015	COG4160	amino acid transport
N4267_RS05020	COG0708	Exodeoxyribonuclease III
N4267_RS05030	COG3923	Primosomal replication protein n
N4267_RS05035	COG0730	response to heat
N4267_RS05040	COG1199	ATP-dependent helicase activity
N4267_RS05050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N4267_RS05055	COG3012	SEC-C Motif Domain Protein
N4267_RS05060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N4267_RS05065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N4267_RS05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N4267_RS05075	COG0215	cysteine-tRNA ligase activity
N4267_RS05080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N4267_RS05085	COG0632	four-way junction helicase activity
N4267_RS05095	COG1271	oxidase subunit
N4267_RS05100	COG1294	oxidase, subunit
N4267_RS05105	COG4890	Cyd operon protein YbgT
N4267_RS05115	COG0824	Thioesterase
N4267_RS05120	COG0811	peptide transport
N4267_RS05135	COG0823	Involved in the tonB-independent uptake of proteins
N4267_RS05140	COG2885	chlorophyll binding
N4267_RS05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N4267_RS05160	COG0784	Response regulator, receiver
N4267_RS05160	COG5002	protein histidine kinase activity
N4267_RS05170	COG1482	cell wall glycoprotein biosynthetic process
N4267_RS05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4267_RS05175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4267_RS05175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4267_RS05180	COG2207	Transcriptional regulator
N4267_RS05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4267_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4267_RS05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4267_RS05215	COG4628	conserved protein (DUF2132)
N4267_RS05225	COG0415	Belongs to the DNA photolyase family
N4267_RS05310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N4267_RS05350	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
N4267_RS05405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N4267_RS05480	COG3064	Membrane
N4267_RS05515	COG2351	hydroxyisourate hydrolase activity
N4267_RS05525	COG4932	domain protein
N4267_RS05525	COG5492	domain, Protein
N4267_RS05535	COG2165	general secretion pathway protein
N4267_RS05550	COG4796	Type ii and iii secretion system protein
N4267_RS05570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4267_RS05575	COG1459	type II secretion system
N4267_RS05595	COG2207	Transcriptional regulator
N4267_RS05640	COG3710	Transcriptional regulator
N4267_RS05645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4267_RS05690	COG0629	single-stranded DNA binding
N4267_RS05710	COG0714	Associated with various cellular activities
N4267_RS05735	COG2003	Belongs to the UPF0758 family
N4267_RS05775	COG3311	Transcriptional regulator
N4267_RS05780	COG0582	viral genome integration into host DNA
N4267_RS05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4267_RS05805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N4267_RS05805	COG3008	intermembrane lipid transfer
N4267_RS05810	COG2995	paraquat-inducible protein a
N4267_RS05815	COG1309	transcriptional regulator
N4267_RS05820	COG1012	belongs to the aldehyde dehydrogenase family
N4267_RS05840	COG1960	acyl-CoA dehydrogenase activity
N4267_RS05845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N4267_RS05850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N4267_RS05860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N4267_RS05875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N4267_RS05880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N4267_RS05885	COG0297	glycogen (starch) synthase activity
N4267_RS05905	COG3070	regulator of competence-specific genes
N4267_RS05910	COG1609	Transcriptional regulator
N4267_RS05920	COG0745	RESPONSE REGULATOR receiver
N4267_RS05925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N4267_RS05930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N4267_RS05935	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
N4267_RS05940	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N4267_RS05965	COG1032	radical SAM domain protein
N4267_RS05970	COG5001	Diguanylate cyclase
N4267_RS05975	COG0612	Peptidase, M16
N4267_RS05990	COG0583	DNA-binding transcription factor activity
N4267_RS05995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N4267_RS06005	COG2350	Protein conserved in bacteria
N4267_RS06010	COG1607	acyl-coa hydrolase
N4267_RS06025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N4267_RS06030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N4267_RS06040	COG2116	formate transmembrane transporter activity
N4267_RS06045	COG4459	periplasmic nitrate reductase
N4267_RS06050	COG3005	denitrification pathway
N4267_RS06055	COG0243	molybdopterin cofactor binding
N4267_RS06075	COG1227	inorganic diphosphatase activity
N4267_RS06095	COG4172	Belongs to the ABC transporter superfamily
N4267_RS06110	COG4168	peptide transport system, permease
N4267_RS06120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N4267_RS06125	COG1842	Phage shock protein A
N4267_RS06140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4267_RS06155	COG2818	Glycosylase
N4267_RS06160	COG0589	response to stress
N4267_RS06170	COG0626	cystathionine gamma-synthase activity
N4267_RS06180	COG0733	neurotransmitter:sodium symporter activity
N4267_RS06185	COG0564	pseudouridine synthase activity
N4267_RS06190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N4267_RS06195	COG4136	ATPase activity
N4267_RS06200	COG4135	transport system, permease component
N4267_RS06205	COG4134	Bacterial extracellular solute-binding protein
N4267_RS06215	COG3313	Fe-S protein
N4267_RS06225	COG0814	amino acid
N4267_RS06235	COG2239	Acts as a magnesium transporter
N4267_RS06240	COG2205	protein histidine kinase activity
N4267_RS06240	COG0784	Response regulator, receiver
N4267_RS06255	COG4934	collagen metabolic process
N4267_RS06290	COG0840	transmembrane signaling receptor activity
N4267_RS06300	COG5001	Diguanylate cyclase
N4267_RS06300	COG4251	negative regulation of phosphorylation
N4267_RS06300	COG3706	GGDEF domain
N4267_RS06300	COG2203	Gaf domain
N4267_RS06305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N4267_RS06325	COG1061	Type III restriction enzyme res subunit
N4267_RS06330	COG1187	pseudouridine synthase activity
N4267_RS06335	COG2814	Major facilitator Superfamily
N4267_RS06345	COG0702	epimerase
N4267_RS06350	COG0534	Mate efflux family protein
N4267_RS06355	COG4181	ATPase activity
N4267_RS06360	COG0577	efflux transmembrane transporter activity
N4267_RS06370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N4267_RS06380	COG1748	Saccharopine dehydrogenase
N4267_RS06395	COG1538	Outer membrane efflux protein
N4267_RS06415	COG0583	DNA-binding transcription factor activity
N4267_RS06425	COG1451	nucleotide metabolic process
N4267_RS06440	COG3063	Type IV pilus biogenesis stability protein PilW
N4267_RS06445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N4267_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4267_RS06480	COG3290	protein histidine kinase activity
N4267_RS06485	COG4565	transcriptional regulatory protein
N4267_RS06495	COG0835	chemotaxis
N4267_RS06495	COG0784	Response regulator, receiver
N4267_RS06545	COG1085	galactose-1-phosphate uridylyltransferase
N4267_RS06550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N4267_RS06555	COG2017	converts alpha-aldose to the beta-anomer
N4267_RS06570	COG3527	Alpha-acetolactate decarboxylase
N4267_RS06580	COG3064	Membrane
N4267_RS06590	COG0753	catalase activity
N4267_RS06610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N4267_RS06635	COG3097	Belongs to the UPF0267 family
N4267_RS06660	COG1271	oxidase subunit
N4267_RS06665	COG1294	oxidase, subunit
N4267_RS06670	COG1136	(ABC) transporter
N4267_RS06670	COG4591	ABC-type transport system involved in lipoprotein release permease component
N4267_RS06675	COG0577	efflux transmembrane transporter activity
N4267_RS06675	COG1136	(ABC) transporter
N4267_RS06730	COG2816	NAD+ diphosphatase activity
N4267_RS06735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N4267_RS06750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N4267_RS06760	COG2723	6-phospho-beta-galactosidase activity
N4267_RS06765	COG1609	Transcriptional regulator
N4267_RS06770	COG0251	oxidation-reduction process
N4267_RS06775	COG2731	YhcH YjgK YiaL family protein
N4267_RS06780	COG0584	glycerophosphoryl diester phosphodiesterase
N4267_RS06785	COG1349	DNA-binding transcription factor activity
N4267_RS06790	COG3842	ATPase activity
N4267_RS06795	COG0395	ABC-type sugar transport system, permease component
N4267_RS06800	COG1175	transmembrane transport
N4267_RS06815	COG0811	peptide transport
N4267_RS06820	COG0811	peptide transport
N4267_RS06825	COG0848	biopolymer transport protein
N4267_RS06830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N4267_RS06840	COG1793	dna ligase
N4267_RS06850	COG0534	Mate efflux family protein
N4267_RS06860	COG3001	Fructosamine kinase
N4267_RS06870	COG0791	NLP P60 protein
N4267_RS06875	COG0840	transmembrane signaling receptor activity
N4267_RS06885	COG3148	PFAM DTW domain containing protein
N4267_RS06890	COG1940	carbohydrate kinase activity
N4267_RS06905	COG0746	molybdenum cofactor guanylyltransferase activity
N4267_RS06910	COG3842	ATPase activity
N4267_RS06915	COG4662	Binding-protein-dependent transport system inner membrane component
N4267_RS06925	COG2204	response regulator
N4267_RS06930	COG3852	Histidine kinase
N4267_RS06935	COG0488	(ABC) transporter
N4267_RS06940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N4267_RS06970	COG0243	molybdopterin cofactor binding
N4267_RS06970	COG3383	formate dehydrogenase (NAD+) activity
N4267_RS06975	COG0437	4 iron, 4 sulfur cluster binding
N4267_RS06990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N4267_RS06995	COG1666	GTP binding
N4267_RS07000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N4267_RS07015	COG2996	Protein conserved in bacteria
N4267_RS07025	COG3008	intermembrane lipid transfer
N4267_RS07030	COG2995	paraquat-inducible protein a
N4267_RS07035	COG1132	(ABC) transporter
N4267_RS07040	COG1956	GAF domain-containing protein
N4267_RS07045	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
N4267_RS07060	COG0308	aminopeptidase N
N4267_RS07075	COG0167	dihydroorotate dehydrogenase activity
N4267_RS07085	COG0116	Belongs to the methyltransferase superfamily
N4267_RS07085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N4267_RS07095	COG0488	(ABC) transporter
N4267_RS07110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N4267_RS07115	COG1067	ATP-dependent peptidase activity
N4267_RS07120	COG3120	sequence-specific DNA binding
N4267_RS07135	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
N4267_RS07135	COG3064	Membrane
N4267_RS07135	COG1073	alpha beta
N4267_RS07140	COG2994	toxin metabolic process
N4267_RS07165	COG0784	Response regulator, receiver
N4267_RS07165	COG2205	protein histidine kinase activity
N4267_RS07180	COG3278	Belongs to the heme-copper respiratory oxidase family
N4267_RS07195	COG2010	Cytochrome c
N4267_RS07205	COG2217	Heavy metal translocating P-type atpase
N4267_RS07220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N4267_RS07225	COG0589	response to stress
N4267_RS07230	COG0037	tRNA processing
N4267_RS07250	COG3842	ATPase activity
N4267_RS07260	COG1177	transmembrane transport
N4267_RS07270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N4267_RS07285	COG1115	amino acid carrier protein
N4267_RS07290	COG1280	lysine exporter protein (LysE YggA)
N4267_RS07320	COG3501	Rhs element vgr protein
N4267_RS07330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N4267_RS07350	COG0513	Belongs to the DEAD box helicase family
N4267_RS07355	COG2076	Multidrug Resistance protein
N4267_RS07360	COG0415	Belongs to the DNA photolyase family
N4267_RS07365	COG0477	Major facilitator Superfamily
N4267_RS07370	COG0583	DNA-binding transcription factor activity
N4267_RS07380	COG0402	S-adenosylhomocysteine deaminase activity
N4267_RS07385	COG0095	Lipoate-protein ligase
N4267_RS07390	COG0443	Heat shock 70 kDa protein
N4267_RS07400	COG1643	Atp-dependent helicase
N4267_RS07430	COG0443	Heat shock 70 kDa protein
N4267_RS07435	COG0443	Heat shock 70 kDa protein
N4267_RS07470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N4267_RS07475	COG0602	queuosine metabolic process
N4267_RS07480	COG0561	phosphatase activity
N4267_RS07490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4267_RS07495	COG4597	amino acid ABC transporter
N4267_RS07500	COG0765	amino acid transport
N4267_RS07505	COG1126	abc transporter atp-binding protein
N4267_RS07510	COG0670	Belongs to the BI1 family
N4267_RS07515	COG2920	part of a sulfur-relay system
N4267_RS07520	COG1254	Belongs to the acylphosphatase family
N4267_RS07525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N4267_RS07530	COG3706	GGDEF domain
N4267_RS07540	COG4999	Histidine kinase
N4267_RS07540	COG3437	response regulator, receiver
N4267_RS07540	COG2205	protein histidine kinase activity
N4267_RS07540	COG3850	Histidine kinase
N4267_RS07545	COG3437	response regulator, receiver
N4267_RS07550	COG0625	glutathione transferase activity
N4267_RS07560	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N4267_RS07570	COG2195	Cleaves the N-terminal amino acid of tripeptides
N4267_RS07600	COG0372	Belongs to the citrate synthase family
N4267_RS07605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N4267_RS07645	COG1566	PFAM secretion protein HlyD family protein
N4267_RS07665	COG1129	ABC transporter
N4267_RS07690	COG0745	RESPONSE REGULATOR receiver
N4267_RS07695	COG5002	protein histidine kinase activity
N4267_RS07700	COG3713	MltA-interacting MipA family protein
N4267_RS07705	COG2990	Protein conserved in bacteria
N4267_RS07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4267_RS07715	COG4191	Histidine kinase
N4267_RS07720	COG0471	metal ion transport
N4267_RS07730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N4267_RS07745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N4267_RS07755	COG3768	UPF0283 membrane protein
N4267_RS07760	COG3106	COG3106 Predicted ATPase
N4267_RS07780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N4267_RS07785	COG0494	nUDIX hydrolase
N4267_RS07790	COG0814	amino acid
N4267_RS07795	COG1760	l-serine dehydratase
N4267_RS07800	COG0720	synthase
N4267_RS07805	COG0840	transmembrane signaling receptor activity
N4267_RS07810	COG0017	Asparaginyl-tRNA synthetase
N4267_RS07815	COG0351	phosphomethylpyrimidine kinase
N4267_RS07820	COG2770	Histidine kinase
N4267_RS07820	COG3437	response regulator, receiver
N4267_RS07825	COG1448	Aminotransferase
N4267_RS07840	COG0840	transmembrane signaling receptor activity
N4267_RS07845	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
N4267_RS07850	COG2943	transferase activity, transferring hexosyl groups
N4267_RS07855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N4267_RS07860	COG1846	Transcriptional regulator
N4267_RS07885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N4267_RS07900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N4267_RS07905	COG3108	Peptidase M15
N4267_RS07935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N4267_RS07945	COG2814	Major facilitator Superfamily
N4267_RS07955	COG1054	Belongs to the UPF0176 family
N4267_RS07965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N4267_RS07970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4267_RS07975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N4267_RS08020	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
N4267_RS08025	COG4139	cobalamin transport
N4267_RS08030	COG2988	succinylglutamate desuccinylase activity
N4267_RS08045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N4267_RS08050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N4267_RS08055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4267_RS08060	COG1823	symporter activity
N4267_RS08065	COG2925	Exonuclease
N4267_RS08070	COG1380	Effector of murein hydrolase LrgA
N4267_RS08075	COG1346	cytolysis
N4267_RS08105	COG0776	regulation of translation
N4267_RS08110	COG0072	phenylalanine-tRNA ligase activity
N4267_RS08110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4267_RS08115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N4267_RS08155	COG0322	excinuclease ABC activity
N4267_RS08160	COG2197	response regulator
N4267_RS08165	COG0417	DNA replication proofreading
N4267_RS08170	COG5001	Diguanylate cyclase
N4267_RS08180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N4267_RS08185	COG3099	Belongs to the UPF0263 family
N4267_RS08200	COG1228	amidohydrolase
N4267_RS08205	COG0010	Belongs to the arginase family
N4267_RS08210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N4267_RS08215	COG2986	histidine ammonia-lyase
N4267_RS08235	COG0247	lactate metabolic process
N4267_RS08235	COG0277	FAD linked oxidase domain protein
N4267_RS08250	COG2885	chlorophyll binding
N4267_RS08270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N4267_RS08280	COG0281	malic enzyme
N4267_RS08290	COG2949	membrane
N4267_RS08295	COG3706	GGDEF domain
N4267_RS08300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N4267_RS08310	COG0492	ferredoxin-NADP+ reductase activity
N4267_RS08315	COG4988	ABC transporter
N4267_RS08320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N4267_RS08325	COG1187	pseudouridine synthase activity
N4267_RS08330	COG0009	L-threonylcarbamoyladenylate synthase
N4267_RS08335	COG0613	PHP domain protein
N4267_RS08345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N4267_RS08350	COG0512	Glutamine amidotransferase of anthranilate synthase
N4267_RS08355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N4267_RS08360	COG0135	phosphoribosylanthranilate isomerase activity
N4267_RS08360	COG0134	indole-3-glycerol-phosphate synthase activity
N4267_RS08365	COG0133	tryptophan synthase activity
N4267_RS08370	COG0159	tryptophan synthase activity
N4267_RS08380	COG1435	thymidine kinase activity
N4267_RS08385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N4267_RS08390	COG1801	Protein of unknown function DUF72
N4267_RS08395	COG4106	trans-aconitate 2-methyltransferase activity
N4267_RS08400	COG0500	methyltransferase
N4267_RS08405	COG0189	ligase activity
N4267_RS08405	COG4067	protein conserved in archaea
N4267_RS08420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N4267_RS08430	COG3852	Histidine kinase
N4267_RS08445	COG3070	regulator of competence-specific genes
N4267_RS08455	COG2431	L-lysine efflux transmembrane transporter activity
N4267_RS08465	COG0076	glutamate decarboxylase activity
N4267_RS08470	COG1737	Transcriptional regulator
N4267_RS08475	COG1012	belongs to the aldehyde dehydrogenase family
N4267_RS08475	COG1454	alcohol dehydrogenase
N4267_RS08480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N4267_RS08485	COG2985	domain, Protein
N4267_RS08485	COG3273	potassium ion transport
N4267_RS08490	COG0542	response to heat
N4267_RS08495	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N4267_RS08500	COG1278	Cold shock
N4267_RS08510	COG1187	pseudouridine synthase activity
N4267_RS08515	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N4267_RS08515	COG0140	phosphoribosyl-ATP diphosphatase activity
N4267_RS08520	COG0107	imidazoleglycerol-phosphate synthase activity
N4267_RS08525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N4267_RS08530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N4267_RS08535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N4267_RS08535	COG0131	Imidazoleglycerol-phosphate dehydratase
N4267_RS08540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N4267_RS08545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N4267_RS08550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N4267_RS08555	COG1757	Na H antiporter
N4267_RS08560	COG2916	Histone family protein nucleoid-structuring protein H-NS
N4267_RS08565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4267_RS08570	COG0482	sulfurtransferase activity
N4267_RS08575	COG2915	High frequency lysogenization protein hflD homolog
N4267_RS08580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N4267_RS08590	COG2268	Band 7 protein
N4267_RS08600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N4267_RS08615	COG0300	oxidoreductase activity
N4267_RS08625	COG0501	Belongs to the peptidase M48B family
N4267_RS08635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N4267_RS08640	COG2226	methyltransferase
N4267_RS08645	COG0156	8-amino-7-oxononanoate synthase activity
N4267_RS08650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N4267_RS08655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N4267_RS08660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N4267_RS08665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N4267_RS08670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N4267_RS08675	COG0653	protein targeting
N4267_RS08680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4267_RS08685	COG2199	diguanylate cyclase activity
N4267_RS08685	COG2203	Gaf domain
N4267_RS08695	COG4120	Belongs to the binding-protein-dependent transport system permease family
N4267_RS08705	COG4628	conserved protein (DUF2132)
N4267_RS08710	COG3092	negative regulation of chromosome organization
N4267_RS08715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N4267_RS08720	COG0280	phosphate acetyltransferase
N4267_RS08720	COG0857	belongs to the CobB CobQ family
N4267_RS08725	COG0435	Glutathione S-transferase
N4267_RS08730	COG4608	Belongs to the ABC transporter superfamily
N4267_RS08735	COG0444	Belongs to the ABC transporter superfamily
N4267_RS08740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4267_RS08745	COG0601	transmembrane transport
N4267_RS08765	COG2204	response regulator
N4267_RS08770	COG3300	MHYT domain
N4267_RS08770	COG5001	Diguanylate cyclase
N4267_RS08775	COG3852	Histidine kinase
N4267_RS08780	COG5002	protein histidine kinase activity
N4267_RS08790	COG2201	protein-glutamate methylesterase activity
N4267_RS08805	COG0009	L-threonylcarbamoyladenylate synthase
N4267_RS08820	COG1881	PFAM PEBP family protein
N4267_RS08845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N4267_RS08850	COG0640	Transcriptional regulator
N4267_RS08860	COG3706	GGDEF domain
N4267_RS08880	COG1946	Acyl-CoA thioesterase
N4267_RS08885	COG1522	sequence-specific DNA binding
N4267_RS08895	COG0616	signal peptide processing
N4267_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
N4267_RS08905	COG2983	Belongs to the UPF0260 family
N4267_RS08915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N4267_RS08920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N4267_RS08925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N4267_RS08930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N4267_RS08935	COG2832	Protein of unknown function (DUF454)
N4267_RS08945	COG0745	RESPONSE REGULATOR receiver
N4267_RS08950	COG0583	DNA-binding transcription factor activity
N4267_RS08955	COG0778	Nitroreductase
N4267_RS08960	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4267_RS08960	COG1024	Enoyl-CoA hydratase
N4267_RS08965	COG0183	Belongs to the thiolase family
N4267_RS08980	COG2067	long-chain fatty acid transport protein
N4267_RS08990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N4267_RS08995	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
N4267_RS09000	COG2982	Protein involved in outer membrane biogenesis
N4267_RS09005	COG0572	uridine kinase
N4267_RS09010	COG0489	protein tyrosine kinase activity
N4267_RS09015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4267_RS09015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N4267_RS09025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N4267_RS09035	COG0617	tRNA 3'-terminal CCA addition
N4267_RS09035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N4267_RS09035	COG0517	IMP dehydrogenase activity
N4267_RS09040	COG2199	diguanylate cyclase activity
N4267_RS09045	COG0314	molybdopterin synthase activity
N4267_RS09050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N4267_RS09055	COG0315	cyclic pyranopterin monophosphate synthase activity
N4267_RS09060	COG0521	Mo-molybdopterin cofactor biosynthetic process
N4267_RS09065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N4267_RS09070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N4267_RS09075	COG2198	Histidine kinase
N4267_RS09080	COG2204	response regulator
N4267_RS09085	COG0556	nucleotide-excision repair
N4267_RS09095	COG4657	Part of a membrane complex involved in electron transport
N4267_RS09100	COG2878	Part of a membrane complex involved in electron transport
N4267_RS09105	COG4656	Part of a membrane complex involved in electron transport
N4267_RS09120	COG4660	Part of a membrane complex involved in electron transport
N4267_RS09125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N4267_RS09130	COG0346	lactoylglutathione lyase activity
N4267_RS09150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N4267_RS09155	COG2056	Na+-H+ antiporter family
N4267_RS09160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N4267_RS09165	COG1286	toxin biosynthetic process
N4267_RS09170	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
N4267_RS09175	COG0285	dihydrofolate synthase activity
N4267_RS09180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N4267_RS09185	COG0101	tRNA pseudouridine synthase activity
N4267_RS09205	COG1263	PTS System
N4267_RS09205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4267_RS09205	COG2190	(PTS) system
N4267_RS09210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N4267_RS09215	COG1846	Transcriptional regulator
N4267_RS09215	COG1940	carbohydrate kinase activity
N4267_RS09220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N4267_RS09220	COG4651	solute:proton antiporter activity
N4267_RS09225	COG0367	asparagine synthase
N4267_RS09235	COG3104	oligopeptide transport
N4267_RS09240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N4267_RS09245	COG0563	adenylate kinase activity
N4267_RS09250	COG0326	Molecular chaperone. Has ATPase activity
N4267_RS09255	COG3710	Transcriptional regulator
N4267_RS09270	COG0622	Phosphoesterase
N4267_RS09275	COG1090	epimerase
N4267_RS09280	COG0300	oxidoreductase activity
N4267_RS09285	COG3118	belongs to the thioredoxin family
N4267_RS09290	COG0330	HflC and HflK could
N4267_RS09295	COG1585	Membrane protein implicated in regulation of membrane protease activity
N4267_RS09300	COG0789	Transcriptional regulator
N4267_RS09315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N4267_RS09320	COG3115	cell septum assembly
N4267_RS09325	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
N4267_RS09330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N4267_RS09335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4267_RS09345	COG2190	(PTS) system
N4267_RS09350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N4267_RS09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N4267_RS09360	COG1702	phosphate starvation-inducible protein PhoH
N4267_RS09365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N4267_RS09370	COG4535	Mg2 and Co2 transporter CorC
N4267_RS09375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N4267_RS09380	COG2888	peptidyl-tyrosine sulfation
N4267_RS09385	COG0495	leucyl-tRNA aminoacylation
N4267_RS09390	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N4267_RS09395	COG1466	dna polymerase III delta subunit
N4267_RS09400	COG0799	negative regulation of ribosome biogenesis
N4267_RS09405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N4267_RS09410	COG0768	penicillin binding
N4267_RS09415	COG0772	Belongs to the SEDS family
N4267_RS09420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N4267_RS09425	COG1686	Belongs to the peptidase S11 family
N4267_RS09430	COG2921	Belongs to the UPF0250 family
N4267_RS09435	COG0321	lipoyl(octanoyl) transferase activity
N4267_RS09440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N4267_RS09450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N4267_RS09475	COG1596	polysaccharide export
N4267_RS09485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N4267_RS09515	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
N4267_RS09525	COG0438	transferase activity, transferring glycosyl groups
N4267_RS09535	COG1045	serine acetyltransferase
N4267_RS09555	COG0110	maltose O-acetyltransferase activity
N4267_RS09560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N4267_RS09565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N4267_RS09570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N4267_RS09575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4267_RS09605	COG0366	Alpha amylase catalytic
N4267_RS09610	COG1263	PTS System
N4267_RS09610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4267_RS09615	COG1609	Transcriptional regulator
N4267_RS09620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N4267_RS09625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N4267_RS09630	COG2011	ABC-type metal ion transport system permease component
N4267_RS09635	COG1464	Belongs to the NlpA lipoprotein family
N4267_RS09640	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N4267_RS09650	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N4267_RS09650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N4267_RS09665	COG1611	Belongs to the LOG family
N4267_RS09670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N4267_RS09675	COG2363	Small membrane protein
N4267_RS09680	COG0583	DNA-binding transcription factor activity
N4267_RS09685	COG0301	tRNA thio-modification
N4267_RS09685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N4267_RS09695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N4267_RS09705	COG1722	exodeoxyribonuclease VII activity
N4267_RS09710	COG0142	geranyltranstransferase activity
N4267_RS09715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N4267_RS09720	COG0564	pseudouridine synthase activity
N4267_RS09725	COG3098	single-species biofilm formation
N4267_RS09740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N4267_RS09750	COG1671	Belongs to the UPF0178 family
N4267_RS09755	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N4267_RS09760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N4267_RS09765	COG0254	rRNA binding
N4267_RS09770	COG1720	tRNA m6t6A37 methyltransferase activity
N4267_RS09775	COG0442	prolyl-tRNA aminoacylation
N4267_RS09795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N4267_RS09795	COG0047	phosphoribosylformylglycinamidine synthase activity
N4267_RS09805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N4267_RS09820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N4267_RS09850	COG0484	heat shock protein binding
N4267_RS09855	COG0443	Heat shock 70 kDa protein
N4267_RS09865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N4267_RS09870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N4267_RS09875	COG0497	DNA recombination
N4267_RS09880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N4267_RS09885	COG2914	Belongs to the UPF0125 (RnfH) family
N4267_RS09890	COG2867	negative regulation of translational initiation
N4267_RS09895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N4267_RS09905	COG0582	viral genome integration into host DNA
N4267_RS09910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N4267_RS09925	COG0732	type I restriction modification DNA specificity domain
N4267_RS09930	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
N4267_RS09970	COG3501	Rhs element vgr protein
N4267_RS10025	COG2003	Belongs to the UPF0758 family
N4267_RS10100	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N4267_RS10105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N4267_RS10110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N4267_RS10130	COG3051	citrate lyase alpha subunit
N4267_RS10135	COG2301	Belongs to the HpcH HpaI aldolase family
N4267_RS10145	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
N4267_RS10155	COG3630	sodium ion export across plasma membrane
N4267_RS10160	COG0511	ligase activity, forming carbon-carbon bonds
N4267_RS10160	COG5016	pyruvate
N4267_RS10165	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N4267_RS10175	COG4565	transcriptional regulatory protein
N4267_RS10200	COG1115	amino acid carrier protein
N4267_RS10205	COG2015	COG2015, Alkyl sulfatase and related hydrolases
N4267_RS10210	COG0583	DNA-binding transcription factor activity
N4267_RS10220	COG1120	ATPase activity
N4267_RS10225	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4267_RS10230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4267_RS10235	COG4592	Periplasmic binding protein
N4267_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
N4267_RS10250	COG1169	isochorismate synthase
N4267_RS10255	COG1021	2,3-dihydroxybenzoate-AMP ligase
N4267_RS10260	COG1535	isochorismatase
N4267_RS10260	COG3433	isochorismatase activity
N4267_RS10265	COG1584	GPR1 FUN34 yaaH family protein
N4267_RS10275	COG3023	N-Acetylmuramoyl-L-alanine amidase
N4267_RS10285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N4267_RS10285	COG0519	Catalyzes the synthesis of GMP from XMP
N4267_RS10290	COG0517	IMP dehydrogenase activity
N4267_RS10290	COG0516	GMP reductase activity
N4267_RS10295	COG1570	exodeoxyribonuclease VII activity
N4267_RS10310	COG1160	GTP binding
N4267_RS10315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N4267_RS10320	COG2976	Protein conserved in bacteria
N4267_RS10325	COG0124	histidyl-tRNA synthetase
N4267_RS10330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N4267_RS10335	COG1426	Protein conserved in bacteria
N4267_RS10340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N4267_RS10345	COG0105	UTP biosynthetic process
N4267_RS10350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N4267_RS10355	COG2975	iron-sulfur cluster assembly
N4267_RS10360	COG0633	Ferredoxin
N4267_RS10380	COG0822	iron-sulfur transferase activity
N4267_RS10390	COG1959	2 iron, 2 sulfur cluster binding
N4267_RS10400	COG0483	inositol monophosphate 1-phosphatase activity
N4267_RS10405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4267_RS10410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4267_RS10415	COG1862	Preprotein translocase
N4267_RS10425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N4267_RS10430	COG0517	IMP dehydrogenase activity
N4267_RS10440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N4267_RS10445	COG0583	DNA-binding transcription factor activity
N4267_RS10450	COG0450	alkyl hydroperoxide reductase
N4267_RS10455	COG3142	Participates in the control of copper homeostasis
N4267_RS10470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N4267_RS10475	COG0581	inorganic phosphate transmembrane transporter activity
N4267_RS10485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N4267_RS10490	COG0248	Ppx GppA phosphatase
N4267_RS10500	COG5002	protein histidine kinase activity
N4267_RS10505	COG0745	RESPONSE REGULATOR receiver
N4267_RS10515	COG0826	peptidase U32
N4267_RS10520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4267_RS10565	COG0542	response to heat
N4267_RS10575	COG0564	pseudouridine synthase activity
N4267_RS10580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N4267_RS10585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N4267_RS10590	COG1605	Chorismate mutase
N4267_RS10590	COG0077	Prephenate dehydratase
N4267_RS10595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N4267_RS10600	COG5001	Diguanylate cyclase
N4267_RS10610	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
N4267_RS10620	COG0488	(ABC) transporter
N4267_RS10630	COG0287	Prephenate dehydrogenase
N4267_RS10630	COG1605	Chorismate mutase
N4267_RS10635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N4267_RS10640	COG3275	phosphorelay sensor kinase activity
N4267_RS10645	COG3279	Response regulator of the LytR AlgR family
N4267_RS10655	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N4267_RS10660	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N4267_RS10670	COG1966	Carbon starvation protein
N4267_RS10675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N4267_RS10680	COG1047	Peptidyl-prolyl cis-trans
N4267_RS10685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N4267_RS10695	COG0196	riboflavin kinase activity
N4267_RS10700	COG0728	peptidoglycan biosynthetic process
N4267_RS10705	COG0268	Binds directly to 16S ribosomal RNA
N4267_RS10710	COG0640	Transcriptional regulator
N4267_RS10715	COG0583	DNA-binding transcription factor activity
N4267_RS10720	COG1283	sodium-dependent phosphate transmembrane transporter activity
N4267_RS10725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N4267_RS10730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N4267_RS10735	COG0730	response to heat
N4267_RS10740	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
N4267_RS10745	COG0494	nUDIX hydrolase
N4267_RS10750	COG3066	DNA modification
N4267_RS10755	COG0667	Aldo Keto reductase
N4267_RS10765	COG2204	response regulator
N4267_RS10770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N4267_RS10790	COG0513	Belongs to the DEAD box helicase family
N4267_RS10815	COG3153	acetyltransferase
N4267_RS10820	COG3154	lipid carrier protein
N4267_RS10830	COG0826	peptidase U32
N4267_RS10835	COG0826	peptidase U32
N4267_RS10860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N4267_RS10870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N4267_RS10875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N4267_RS10880	COG0195	Participates in both transcription termination and antitermination
N4267_RS10885	COG0779	Required for maturation of 30S ribosomal subunits
N4267_RS10900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N4267_RS10910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N4267_RS10915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N4267_RS10920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N4267_RS10925	COG1534	Rna-binding protein
N4267_RS10930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N4267_RS10940	COG2027	D-alanyl-D-alanine carboxypeptidase
N4267_RS10945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N4267_RS10950	COG0739	heme binding
N4267_RS10965	COG0316	Belongs to the HesB IscA family
N4267_RS10970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N4267_RS10975	COG0628	permease
N4267_RS10980	COG2813	Specifically methylates the guanine in position
N4267_RS10985	COG0784	Response regulator, receiver
N4267_RS10985	COG2205	protein histidine kinase activity
N4267_RS10990	COG0747	negative chemotaxis
N4267_RS11000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4267_RS11005	COG0444	Belongs to the ABC transporter superfamily
N4267_RS11010	COG4608	Belongs to the ABC transporter superfamily
N4267_RS11020	COG2971	BadF BadG BcrA BcrD
N4267_RS11040	COG3842	ATPase activity
N4267_RS11050	COG1840	ABC-type Fe3 transport system, periplasmic component
N4267_RS11055	COG0004	ammonium transporteR
N4267_RS11060	COG0347	Belongs to the P(II) protein family
N4267_RS11065	COG3112	Uncharacterised protein family (UPF0231)
N4267_RS11070	COG1049	propionate catabolic process, 2-methylcitrate cycle
N4267_RS11075	COG1752	Esterase of the alpha-beta hydrolase superfamily
N4267_RS11080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N4267_RS11085	COG1643	Atp-dependent helicase
N4267_RS11095	COG1489	DNA binding
N4267_RS11105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N4267_RS11115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N4267_RS11120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N4267_RS11125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N4267_RS11130	COG0842	Transport permease protein
N4267_RS11135	COG1131	(ABC) transporter
N4267_RS11140	COG0659	secondary active sulfate transmembrane transporter activity
N4267_RS11145	COG0288	reversible hydration of carbon dioxide
N4267_RS11160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N4267_RS11165	COG3107	peptidoglycan biosynthetic process
N4267_RS11170	COG0792	nuclease activity
N4267_RS11175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N4267_RS11180	COG2823	Periplasmic or secreted lipoprotein
N4267_RS11185	COG2969	positive regulation of protein catabolic process
N4267_RS11190	COG0625	glutathione transferase activity
N4267_RS11195	COG2857	Cytochrome c1
N4267_RS11200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N4267_RS11205	COG0723	plastoquinol--plastocyanin reductase activity
N4267_RS11210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N4267_RS11215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N4267_RS11220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N4267_RS11230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4267_RS11235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N4267_RS11240	COG0335	large ribosomal subunit rRNA binding
N4267_RS11245	COG0336	Belongs to the RNA methyltransferase TrmD family
N4267_RS11250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N4267_RS11255	COG0228	four-way junction DNA binding
N4267_RS11260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N4267_RS11265	COG4137	Cytochrome C assembly protein
N4267_RS11270	COG4536	flavin adenine dinucleotide binding
N4267_RS11275	COG1854	S-ribosylhomocysteine lyase activity
N4267_RS11280	COG2918	glutathione biosynthetic process
N4267_RS11285	COG0612	Peptidase, M16
N4267_RS11290	COG1238	metal cluster binding
N4267_RS11300	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N4267_RS11305	COG0511	ligase activity, forming carbon-carbon bonds
N4267_RS11305	COG5016	pyruvate
N4267_RS11310	COG3630	sodium ion export across plasma membrane
N4267_RS11350	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N4267_RS11355	COG0527	aspartate kinase activity
N4267_RS11360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N4267_RS11370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N4267_RS11380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N4267_RS11385	COG4208	sulfate ABC transporter
N4267_RS11405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N4267_RS11410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N4267_RS11420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N4267_RS11425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N4267_RS11430	COG0585	pseudouridine synthase activity
N4267_RS11435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N4267_RS11440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N4267_RS11445	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N4267_RS11450	COG1968	undecaprenyl-diphosphatase activity
N4267_RS11455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N4267_RS11460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N4267_RS11465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N4267_RS11475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N4267_RS11480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N4267_RS11485	COG1610	YqeY-like protein
N4267_RS11490	COG0358	DNA primase activity
N4267_RS11510	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N4267_RS11515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N4267_RS11520	COG1349	DNA-binding transcription factor activity
N4267_RS11545	COG1279	arginine transmembrane transporter activity
N4267_RS11550	COG0668	transmembrane transport
N4267_RS11555	COG0191	fructose-bisphosphate aldolase activity
N4267_RS11560	COG0126	phosphoglycerate kinase activity
N4267_RS11565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N4267_RS11570	COG4771	TonB-dependent receptor
N4267_RS11575	COG0583	DNA-binding transcription factor activity
N4267_RS11580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N4267_RS11585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N4267_RS11590	COG3091	SprT-like family
N4267_RS11595	COG2356	endonuclease I
N4267_RS11600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N4267_RS11605	COG0189	ligase activity
N4267_RS11610	COG1678	Uncharacterized ACR, COG1678
N4267_RS11615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N4267_RS11620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N4267_RS11640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N4267_RS11645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N4267_RS11650	COG0762	integral membrane protein
N4267_RS11665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N4267_RS11670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N4267_RS11675	COG2066	Belongs to the glutaminase family
N4267_RS11680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N4267_RS11685	COG1194	a g-specific adenine glycosylase
N4267_RS11690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N4267_RS11695	COG0741	lytic transglycosylase activity
N4267_RS11750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N4267_RS11755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N4267_RS11760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4267_RS11765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N4267_RS11770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N4267_RS11775	COG2967	ApaG domain
N4267_RS11780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N4267_RS11790	COG3610	response to peptide
N4267_RS11795	COG2966	Psort location CytoplasmicMembrane, score
N4267_RS11800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N4267_RS11805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N4267_RS11810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N4267_RS11815	COG0142	geranyltranstransferase activity
N4267_RS11820	COG0531	amino acid
N4267_RS11825	COG0039	L-malate dehydrogenase activity
N4267_RS11830	COG1438	arginine binding
N4267_RS11835	COG2358	TRAP transporter, solute receptor (TAXI family
N4267_RS11845	COG0589	response to stress
N4267_RS11865	COG2235	arginine
N4267_RS11870	COG0312	modulator of DNA gyrase
N4267_RS11875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N4267_RS11880	COG3164	Protein of unknown function
N4267_RS11890	COG0424	maF-like protein
N4267_RS11895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N4267_RS11900	COG1792	Involved in formation and maintenance of cell shape
N4267_RS11905	COG1077	Cell shape determining protein MreB Mrl
N4267_RS11935	COG2165	general secretion pathway protein
N4267_RS11940	COG2165	general secretion pathway protein
N4267_RS11950	COG1459	type II secretion system
N4267_RS11955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N4267_RS11965	COG3267	Type II secretory pathway component ExeA
N4267_RS11965	COG3409	Peptidoglycan-binding domain 1 protein
N4267_RS11990	COG2200	EAL domain
N4267_RS11990	COG2199	diguanylate cyclase activity
N4267_RS11995	COG0629	single-stranded DNA binding
N4267_RS12010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N4267_RS12020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N4267_RS12025	COG0527	aspartate kinase activity
N4267_RS12030	COG1410	methionine synthase
N4267_RS12030	COG0646	methionine synthase
N4267_RS12105	COG0175	sulfate reduction
N4267_RS12115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N4267_RS12140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4267_RS12145	COG0735	belongs to the Fur family
N4267_RS12165	COG0432	Pfam Uncharacterised protein family UPF0047
N4267_RS12170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N4267_RS12185	COG0359	binds to the 23S rRNA
N4267_RS12190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N4267_RS12195	COG2965	DNA replication, synthesis of RNA primer
N4267_RS12200	COG0360	Binds together with S18 to 16S ribosomal RNA
N4267_RS12210	COG2906	2 iron, 2 sulfur cluster binding
N4267_RS12215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N4267_RS12220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N4267_RS12225	COG0049	tRNA binding
N4267_RS12240	COG2923	Belongs to the DsrF TusC family
N4267_RS12245	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N4267_RS12250	COG2964	Protein conserved in bacteria
N4267_RS12260	COG0545	Peptidyl-prolyl cis-trans isomerase
N4267_RS12270	COG2900	Belongs to the SlyX family
N4267_RS12275	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
N4267_RS12280	COG0330	HflC and HflK could
N4267_RS12285	COG0330	HflC and HflK could
N4267_RS12290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N4267_RS12295	COG1923	regulation of RNA biosynthetic process
N4267_RS12300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N4267_RS12305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N4267_RS12315	COG0802	atpase or kinase
N4267_RS12320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N4267_RS12370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N4267_RS12375	COG1162	GTPase activity
N4267_RS12380	COG0688	phosphatidylethanolamine metabolic process
N4267_RS12385	COG0471	metal ion transport
N4267_RS12395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N4267_RS12400	COG4942	peptidase
N4267_RS12415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N4267_RS12420	COG2816	NAD+ diphosphatase activity
N4267_RS12425	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
N4267_RS12430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N4267_RS12435	COG0085	RNA polymerase activity
N4267_RS12440	COG0222	ribosome binding
N4267_RS12445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N4267_RS12455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N4267_RS12460	COG0250	Participates in transcription elongation, termination and antitermination
N4267_RS12465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N4267_RS12470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N4267_RS12495	COG1072	(Pantothenic acid kinase))
N4267_RS12505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N4267_RS12515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N4267_RS12560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N4267_RS12575	COG3118	belongs to the thioredoxin family
N4267_RS12580	COG0513	Belongs to the DEAD box helicase family
N4267_RS12585	COG0248	Ppx GppA phosphatase
N4267_RS12590	COG0784	Response regulator, receiver
N4267_RS12590	COG2205	protein histidine kinase activity
N4267_RS12595	COG2814	Major facilitator Superfamily
N4267_RS12610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4267_RS12615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N4267_RS12620	COG0511	ligase activity, forming carbon-carbon bonds
N4267_RS12625	COG0439	Biotin carboxylase
N4267_RS12630	COG2264	protein methyltransferase activity
N4267_RS12635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N4267_RS12640	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N4267_RS12650	COG1609	Transcriptional regulator
N4267_RS12660	COG0387	Pfam Sodium calcium exchanger
N4267_RS12665	COG0129	dihydroxy-acid dehydratase activity
N4267_RS12670	COG3265	gluconokinase activity
N4267_RS12680	COG0800	Aldolase
N4267_RS12700	COG0840	transmembrane signaling receptor activity
N4267_RS12705	COG1982	Orn Lys Arg decarboxylase major
N4267_RS12710	COG0531	amino acid
N4267_RS12715	COG3710	Transcriptional regulator
N4267_RS12720	COG0789	Transcriptional regulator
N4267_RS12735	COG0151	Belongs to the GarS family
N4267_RS12745	COG0776	regulation of translation
N4267_RS12750	COG1253	flavin adenine dinucleotide binding
N4267_RS12755	COG3068	Protein conserved in bacteria
N4267_RS12760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N4267_RS12765	COG1573	uracil-dna glycosylase
N4267_RS12770	COG0668	transmembrane transport
N4267_RS12775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N4267_RS12785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N4267_RS12795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N4267_RS12855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N4267_RS12860	COG0367	asparagine synthase
N4267_RS12870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N4267_RS12870	COG2755	lipolytic protein G-D-S-L family
N4267_RS12885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N4267_RS12895	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
N4267_RS12900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N4267_RS12925	COG0859	PFAM glycosyl transferase family 9
N4267_RS12935	COG1519	Transferase
N4267_RS12960	COG3642	lipopolysaccharide core region biosynthetic process
N4267_RS12965	COG0859	PFAM glycosyl transferase family 9
N4267_RS12970	COG0463	Glycosyl transferase, family 2
N4267_RS12975	COG0859	PFAM glycosyl transferase family 9
N4267_RS12980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N4267_RS12985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N4267_RS12995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N4267_RS13000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N4267_RS13005	COG2003	Belongs to the UPF0758 family
N4267_RS13015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N4267_RS13025	COG1309	transcriptional regulator
N4267_RS13030	COG1560	Kdo2-lipid A biosynthetic process
N4267_RS13035	COG1560	Kdo2-lipid A biosynthetic process
N4267_RS13040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N4267_RS13045	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N4267_RS13050	COG1561	YicC-like family, N-terminal region
N4267_RS13055	COG2862	Uncharacterized protein family, UPF0114
N4267_RS13060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N4267_RS13065	COG1263	PTS System
N4267_RS13065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4267_RS13070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N4267_RS13090	COG1120	ATPase activity
N4267_RS13095	COG4774	siderophore transport
N4267_RS13100	COG1132	(ABC) transporter
N4267_RS13115	COG0514	ATP-dependent DNA helicase (RecQ)
N4267_RS13120	COG2962	Rard protein
N4267_RS13125	COG0405	Gamma-glutamyltransferase
N4267_RS13135	COG1280	lysine exporter protein (LysE YggA)
N4267_RS13140	COG0210	DNA helicase
N4267_RS13150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N4267_RS13155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N4267_RS13180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4267_RS13185	COG0601	transmembrane transport
N4267_RS13190	COG0747	negative chemotaxis
N4267_RS13240	COG1309	transcriptional regulator
N4267_RS13245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N4267_RS13250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N4267_RS13255	COG2960	long-chain fatty acid transporting porin activity
N4267_RS13260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N4267_RS13265	COG0583	DNA-binding transcription factor activity
N4267_RS13335	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
N4267_RS13340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N4267_RS13345	COG1739	Uncharacterized protein family UPF0029
N4267_RS13350	COG1024	Enoyl-CoA hydratase
N4267_RS13350	COG1250	3-hydroxyacyl-CoA dehydrogenase
N4267_RS13355	COG0183	Belongs to the thiolase family
N4267_RS13360	COG0583	DNA-binding transcription factor activity
N4267_RS13365	COG2814	Major facilitator Superfamily
N4267_RS13375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N4267_RS13380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N4267_RS13385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N4267_RS13390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N4267_RS13395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N4267_RS13400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N4267_RS13410	COG0356	it plays a direct role in the translocation of protons across the membrane
N4267_RS13415	COG3312	ion transport
N4267_RS13420	COG1475	DNA binding
N4267_RS13425	COG1192	Involved in chromosome partitioning
N4267_RS13430	COG0357	Ribosomal RNA small subunit methyltransferase G
N4267_RS13435	COG0445	tRNA wobble uridine modification
N4267_RS13440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N4267_RS13445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N4267_RS13450	COG0706	membrane insertase activity
N4267_RS13460	COG0594	ribonuclease P activity
N4267_RS13465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N4267_RS13470	COG1126	abc transporter atp-binding protein
N4267_RS13490	COG1802	Transcriptional regulator
N4267_RS13490	COG4626	Terminase
N4267_RS13520	COG0582	viral genome integration into host DNA
N4267_RS13545	COG1063	alcohol dehydrogenase
N4267_RS13555	COG2873	o-acetylhomoserine
N4267_RS13565	COG0346	lactoylglutathione lyase activity
N4267_RS13590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N4267_RS13595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N4267_RS13600	COG0363	glucosamine-6-phosphate deaminase activity
N4267_RS13605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N4267_RS13630	COG1929	Belongs to the glycerate kinase type-1 family
N4267_RS13635	COG2610	gluconate transmembrane transporter activity
N4267_RS13640	COG3835	regulator
N4267_RS13650	COG0748	coenzyme F420 binding
N4267_RS13655	COG3721	Heme iron utilization protein
N4267_RS13665	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
N4267_RS13670	COG0811	peptide transport
N4267_RS13675	COG0848	biopolymer transport protein
N4267_RS13680	COG4558	Periplasmic binding protein
N4267_RS13685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4267_RS13690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N4267_RS13725	COG3217	Mosc domain protein beta barrel domain protein
N4267_RS13725	COG0633	Ferredoxin
N4267_RS13725	COG3217	Mosc domain protein beta barrel domain protein
N4267_RS13725	COG0633	Ferredoxin
N4267_RS13730	COG0418	dihydroorotase activity
N4267_RS13735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N4267_RS13740	COG2354	Protein conserved in bacteria
N4267_RS13750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N4267_RS13755	COG1278	Cold shock
N4267_RS13780	COG2199	diguanylate cyclase activity
N4267_RS13785	COG1349	DNA-binding transcription factor activity
N4267_RS13800	COG3833	ABC-type maltose transport systems, permease component
N4267_RS13805	COG1175	transmembrane transport
N4267_RS13815	COG3842	ATPase activity
N4267_RS13820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N4267_RS13835	COG0393	Putative heavy-metal-binding
N4267_RS13845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N4267_RS13850	COG0784	Response regulator, receiver
N4267_RS13850	COG0835	chemotaxis
N4267_RS13855	COG1846	Transcriptional regulator
N4267_RS13860	COG3706	GGDEF domain
N4267_RS13895	COG0583	DNA-binding transcription factor activity
N4267_RS13900	COG5001	Diguanylate cyclase
N4267_RS13910	COG1741	Belongs to the pirin family
N4267_RS13915	COG3123	guanosine phosphorylase activity
N4267_RS13925	COG2211	Major facilitator Superfamily
N4267_RS13930	COG0840	transmembrane signaling receptor activity
N4267_RS13935	COG1067	ATP-dependent peptidase activity
N4267_RS13945	COG4172	Belongs to the ABC transporter superfamily
N4267_RS13970	COG0583	DNA-binding transcription factor activity
N4267_RS13980	COG1620	l-lactate permease
N4267_RS13995	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N4267_RS14005	COG0840	transmembrane signaling receptor activity
N4267_RS14025	COG2258	MOSC domain
N4267_RS14030	COG0513	Belongs to the DEAD box helicase family
N4267_RS14040	COG2186	Transcriptional regulator
N4267_RS14050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N4267_RS14060	COG0246	Mannitol dehydrogenase
N4267_RS14065	COG1904	glucuronate isomerase
N4267_RS14070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4267_RS14075	COG0800	Aldolase
N4267_RS14085	COG0583	DNA-binding transcription factor activity
N4267_RS14095	COG1902	pentaerythritol trinitrate reductase activity
N4267_RS14105	COG1132	(ABC) transporter
N4267_RS14115	COG1902	pentaerythritol trinitrate reductase activity
N4267_RS14125	COG1280	lysine exporter protein (LysE YggA)
N4267_RS14130	COG2207	Transcriptional regulator
N4267_RS14150	COG1846	Transcriptional regulator
N4267_RS14155	COG1764	response to oxidative stress
N4267_RS14160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N4267_RS14165	COG0697	spore germination
N4267_RS14175	COG0700	Nucleoside recognition
N4267_RS14180	COG3366	ferrous iron transmembrane transporter activity
N4267_RS14185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N4267_RS14195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N4267_RS14210	COG2259	Doxx family
N4267_RS14235	COG0363	glucosamine-6-phosphate deaminase activity
N4267_RS14250	COG4580	involved in the transport of maltose and maltodextrins
N4267_RS14265	COG0840	transmembrane signaling receptor activity
N4267_RS14275	COG0840	transmembrane signaling receptor activity
N4267_RS14280	COG3706	GGDEF domain
N4267_RS14290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N4267_RS14295	COG1126	abc transporter atp-binding protein
N4267_RS14305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4267_RS14310	COG4597	amino acid ABC transporter
N4267_RS14315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N4267_RS14320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4267_RS14320	COG2213	PTS system mannitol-specific
N4267_RS14325	COG0246	Mannitol dehydrogenase
N4267_RS14330	COG3722	fumarate hydratase activity
N4267_RS14335	COG0673	inositol 2-dehydrogenase activity
N4267_RS14365	COG2910	NAD(P)H-binding
N4267_RS14375	COG0840	transmembrane signaling receptor activity
N4267_RS14380	COG4221	oxidoreductase activity
N4267_RS14390	COG1901	pseudouridine methyltransferase
N4267_RS14405	COG0531	amino acid
N4267_RS14410	COG1982	Orn Lys Arg decarboxylase major
N4267_RS14440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N4267_RS14465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N4267_RS14530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N4267_RS14535	COG0840	transmembrane signaling receptor activity
N4267_RS14540	COG0835	chemotaxis
N4267_RS14545	COG0835	chemotaxis
N4267_RS14550	COG0643	Histidine kinase
N4267_RS14550	COG2198	Histidine kinase
N4267_RS14570	COG0601	transmembrane transport
N4267_RS14575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N4267_RS14580	COG4608	Belongs to the ABC transporter superfamily
N4267_RS14585	COG2194	sulfuric ester hydrolase activity
N4267_RS14590	COG0642	Histidine kinase
N4267_RS14605	COG4221	oxidoreductase activity
N4267_RS14625	COG1444	tRNA N-acetyltransferase activity
N4267_RS14630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N4267_RS14665	COG0217	transcriptional regulatory protein
N4267_RS14670	COG2084	Dehydrogenase
N4267_RS14685	COG2909	trisaccharide binding
N4267_RS14690	COG0058	SHG alpha-glucan phosphorylase activity
N4267_RS14695	COG1640	4-alpha-glucanotransferase
N4267_RS14700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N4267_RS14710	COG3501	Rhs element vgr protein
N4267_RS14715	COG4104	PAAR repeat-containing protein
N4267_RS14745	COG0471	metal ion transport
N4267_RS14750	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N4267_RS14780	COG0671	phosphoesterase, PA-phosphatase related
N4267_RS14790	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N4267_RS14800	COG1999	signal sequence binding
N4267_RS14815	COG0786	glutamate:sodium symporter activity
N4267_RS14835	COG1566	PFAM secretion protein HlyD family protein
N4267_RS14860	COG0813	purine-nucleoside phosphorylase activity
N4267_RS14865	COG3272	Protein of unknown function (DUF1722)
N4267_RS14875	COG0415	Belongs to the DNA photolyase family
N4267_RS14880	COG1376	ErfK ybiS ycfS ynhG family protein
N4267_RS14880	COG1388	LysM domain
N4267_RS14890	COG0513	Belongs to the DEAD box helicase family
N4267_RS14895	COG1770	oligopeptidase
N4267_RS14920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N4267_RS14925	COG0573	inorganic phosphate transmembrane transporter activity
N4267_RS14930	COG0581	inorganic phosphate transmembrane transporter activity
N4267_RS14935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N4267_RS14950	COG3314	Sporulation integral membrane protein YlbJ
N4267_RS14955	COG0659	secondary active sulfate transmembrane transporter activity
N4267_RS14965	COG0739	heme binding
N4267_RS14970	COG3300	MHYT domain
N4267_RS14970	COG5001	Diguanylate cyclase
N4267_RS14975	COG0583	DNA-binding transcription factor activity
N4267_RS14980	COG2814	Major facilitator Superfamily
N4267_RS15005	COG1301	dicarboxylic acid transport
N4267_RS15020	COG1342	Belongs to the UPF0251 family
N4267_RS15055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N4267_RS15060	COG0673	inositol 2-dehydrogenase activity
N4267_RS15070	COG2200	EAL domain
N4267_RS15070	COG2771	luxR family
N4267_RS15075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4267_RS15085	COG0564	pseudouridine synthase activity
N4267_RS15150	COG3829	transcription factor binding
N4267_RS15195	COG1869	D-ribose catabolic process
N4267_RS15200	COG1129	ABC transporter
N4267_RS15205	COG1172	Belongs to the binding-protein-dependent transport system permease family
N4267_RS15210	COG1879	ABC-type sugar transport system periplasmic component
N4267_RS15215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4267_RS15220	COG1609	Transcriptional regulator
N4267_RS15230	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N4267_RS15240	COG0584	glycerophosphoryl diester phosphodiesterase
N4267_RS15245	COG2271	Major facilitator Superfamily
N4267_RS15280	COG0579	oxidoreductase
N4267_RS15290	COG0242	peptide deformylase activity
N4267_RS15295	COG1017	nitric oxide dioxygenase activity
N4267_RS15295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4267_RS15300	COG1320	monovalent cation:proton antiporter activity
N4267_RS15305	COG2212	antiporter activity
N4267_RS15310	COG1863	multisubunit Na H antiporter MnhE subunit
N4267_RS15315	COG0651	ATP synthesis coupled electron transport
N4267_RS15320	COG1006	Multisubunit Na H antiporter MnhC subunit
N4267_RS15325	COG2111	Na H antiporter
N4267_RS15325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N4267_RS15335	COG0589	response to stress
N4267_RS15340	COG0814	amino acid
N4267_RS15350	COG3530	Putative quorum-sensing-regulated virulence factor
N4267_RS15360	COG5002	protein histidine kinase activity
N4267_RS15360	COG5001	Diguanylate cyclase
N4267_RS15365	COG1278	Cold shock
N4267_RS15385	COG2304	oxidoreductase activity
N4267_RS15405	COG0714	Associated with various cellular activities
N4267_RS15410	COG0840	transmembrane signaling receptor activity
N4267_RS15425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N4267_RS15430	COG2195	Cleaves the N-terminal amino acid of tripeptides
N4267_RS15440	COG3604	Transcriptional regulator
N4267_RS15445	COG1017	nitric oxide dioxygenase activity
N4267_RS15445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N4267_RS15450	COG1278	Cold shock
N4267_RS15455	COG3036	rescue of stalled ribosome
N4267_RS15480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N4267_RS15480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N4267_RS15485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N4267_RS15495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N4267_RS15505	COG0516	GMP reductase activity
N4267_RS15515	COG0326	Molecular chaperone. Has ATPase activity
N4267_RS15530	COG0513	Belongs to the DEAD box helicase family
N4267_RS15535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N4267_RS15540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N4267_RS15545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N4267_RS15550	COG0784	Response regulator, receiver
N4267_RS15550	COG3437	response regulator, receiver
N4267_RS15560	COG4191	Histidine kinase
N4267_RS15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4267_RS15570	COG1757	Na H antiporter
N4267_RS15575	COG2814	Major facilitator Superfamily
N4267_RS15585	COG3240	lipase activity
N4267_RS15595	COG0840	transmembrane signaling receptor activity
N4267_RS15600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N4267_RS15605	COG5380	lipid catabolic process
N4267_RS15635	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N4267_RS15640	COG4605	iron ion homeostasis
N4267_RS15645	COG4604	ABC transporter, ATP-binding protein
N4267_RS15650	COG2207	Transcriptional regulator
N4267_RS15665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N4267_RS15670	COG0640	Transcriptional regulator
N4267_RS15675	COG0798	PFAM Bile acid sodium symporter
N4267_RS15705	COG0745	RESPONSE REGULATOR receiver
N4267_RS15715	COG3623	hexulose-6-phosphate isomerase
N4267_RS15720	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N4267_RS15725	COG0561	phosphatase activity
N4267_RS15760	COG0366	Alpha amylase catalytic
N4267_RS15780	COG0745	RESPONSE REGULATOR receiver
N4267_RS15785	COG5000	phosphorelay sensor kinase activity
N4267_RS15785	COG5002	protein histidine kinase activity
N4267_RS15810	COG0583	DNA-binding transcription factor activity
N4267_RS15825	COG1686	Belongs to the peptidase S11 family
N4267_RS15845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N4267_RS15845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N4267_RS15850	COG0509	glycine decarboxylation via glycine cleavage system
N4267_RS15855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N4267_RS15865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N4267_RS15880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N4267_RS15885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N4267_RS15930	COG0384	phenazine biosynthesis protein PhzF
N4267_RS15945	COG0494	nUDIX hydrolase
N4267_RS16045	COG2318	DinB family
N4267_RS16060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N4267_RS16080	COG0456	acetyltransferase
N4267_RS16355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N4267_RS16370	COG2318	DinB family
N4267_RS16490	COG0494	nUDIX hydrolase
N4267_RS16615	COG3040	lipid binding
N4267_RS16620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N4267_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
N4267_RS16750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4267_RS16750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N4267_RS16815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N4267_RS16870	COG3549	Plasmid maintenance system killer
N4267_RS16875	COG3093	addiction module antidote protein HigA
N4267_RS16905	COG5642	Protein of unknown function (DUF2384)
N4267_RS16930	COG0545	Peptidyl-prolyl cis-trans isomerase
N4267_RS16935	COG2885	chlorophyll binding
N4267_RS16945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N4267_RS16950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4267_RS16955	COG1621	beta-fructofuranosidase activity
N4267_RS16960	COG1609	Transcriptional regulator
N4267_RS16965	COG1263	PTS System
N4267_RS16965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N4267_RS17010	COG0446	pyridine nucleotide-disulphide oxidoreductase
N4267_RS17050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N4267_RS17055	COG0583	DNA-binding transcription factor activity
N4267_RS17080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N4267_RS17095	COG2856	Zn peptidase
N4267_RS17120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N4267_RS17130	COG2390	Transcriptional regulator
N4267_RS17135	COG2897	thiosulfate sulfurtransferase activity
N4267_RS17145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N4267_RS17155	COG0302	gtp cyclohydrolase
N4267_RS17160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4267_RS17160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N4267_RS17165	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N4267_RS17170	COG1970	mechanosensitive ion channel activity
N4267_RS17175	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
N4267_RS17190	COG1011	Hydrolase
N4267_RS17195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N4267_RS17200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4267_RS17205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N4267_RS17210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N4267_RS17215	COG1840	ABC-type Fe3 transport system, periplasmic component
N4267_RS17220	COG3842	ATPase activity
N4267_RS17240	COG3104	oligopeptide transport
N4267_RS17265	COG4166	transmembrane transport
N4267_RS17270	COG4174	ABC transporter (Permease)
N4267_RS17275	COG4239	(ABC) transporter, permease
N4267_RS17280	COG4172	Belongs to the ABC transporter superfamily
N4267_RS17285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N4267_RS17300	COG0625	glutathione transferase activity
N4267_RS17320	COG2050	protein possibly involved in aromatic compounds catabolism
N4267_RS17335	COG4771	TonB-dependent receptor
N4267_RS17340	COG0583	DNA-binding transcription factor activity
N4267_RS17345	COG0045	succinate-CoA ligase (ADP-forming) activity
N4267_RS17345	COG1042	CoA-binding domain protein
N4267_RS17345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N4267_RS17365	COG0023	Translation Initiation Factor
N4267_RS17375	COG3140	Belongs to the UPF0181 family
N4267_RS17390	COG0745	RESPONSE REGULATOR receiver
N4267_RS17400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N4267_RS17405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N4267_RS17420	COG3706	GGDEF domain
N4267_RS17440	COG2199	diguanylate cyclase activity
N4267_RS17470	COG2824	Alkylphosphonate utilization operon protein PhnA
N4267_RS17485	COG0737	Belongs to the 5'-nucleotidase family
N4267_RS17490	COG3593	DNA synthesis involved in DNA repair
N4267_RS17500	COG0583	DNA-binding transcription factor activity
N4267_RS17505	COG2116	formate transmembrane transporter activity
N4267_RS17515	COG3038	cytochrome b561
N4267_RS17525	COG2200	EAL domain
N4267_RS17540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N4267_RS17545	COG0745	RESPONSE REGULATOR receiver
N4267_RS17550	COG2205	protein histidine kinase activity
N4267_RS17555	COG0674	pyruvate-flavodoxin oxidoreductase activity
N4267_RS17555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N4267_RS17555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N4267_RS17555	COG1013	pyruvate-flavodoxin oxidoreductase activity
N4267_RS17560	COG3158	transport of potassium into the cell
N4267_RS17570	COG0523	cobalamin synthesis protein
N4267_RS17575	COG0038	chloride channel
N4267_RS17585	COG0156	8-amino-7-oxononanoate synthase activity
N4267_RS17590	COG0784	Response regulator, receiver
N4267_RS17590	COG2205	protein histidine kinase activity
N4267_RS17595	COG0419	ATPase involved in DNA repair
N4267_RS17600	COG0420	3'-5' exonuclease activity
N4267_RS17605	COG1609	Transcriptional regulator
N4267_RS17610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4267_RS17610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N4267_RS17615	COG1105	Belongs to the carbohydrate kinase PfkB family
N4267_RS17620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4267_RS17620	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N4267_RS17620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N4267_RS17625	COG0189	ligase activity
N4267_RS17625	COG4067	protein conserved in archaea
N4267_RS17635	COG0602	queuosine metabolic process
N4267_RS17640	COG1328	CTP reductase activity
N4267_RS17650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N4267_RS17655	COG0840	transmembrane signaling receptor activity
N4267_RS17660	COG3069	C4-dicarboxylate transmembrane transporter activity
N4267_RS17665	COG1760	l-serine dehydratase
N4267_RS17670	COG2197	response regulator
N4267_RS17675	COG3850	Histidine kinase
N4267_RS17680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N4267_RS17690	COG0243	molybdopterin cofactor binding
N4267_RS17710	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N4267_RS17715	COG2197	response regulator
N4267_RS17720	COG3851	Histidine kinase
N4267_RS17725	COG2271	Major facilitator Superfamily
N4267_RS17730	COG1840	ABC-type Fe3 transport system, periplasmic component
N4267_RS17740	COG3842	ATPase activity
N4267_RS17745	COG3243	poly(R)-hydroxyalkanoic acid synthase
N4267_RS17755	COG0183	Belongs to the thiolase family
N4267_RS17765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4267_RS17770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N4267_RS17790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N4267_RS17800	COG1979	alcohol dehydrogenase
N4267_RS17815	COG4191	Histidine kinase
N4267_RS17825	COG2271	Major facilitator Superfamily
N4267_RS17830	COG0469	pyruvate kinase activity
N4267_RS17835	COG0784	Response regulator, receiver
N4267_RS17835	COG2198	Histidine kinase
N4267_RS17835	COG2205	protein histidine kinase activity
N4267_RS17840	COG1879	ABC-type sugar transport system periplasmic component
N4267_RS17845	COG1803	Methylglyoxal synthase
N4267_RS17850	COG1335	isochorismatase
N4267_RS17855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N4267_RS17860	COG0210	DNA helicase
N4267_RS17865	COG1289	transmembrane transporter activity
N4267_RS17895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N4267_RS17900	COG4149	molybdate abc transporter
N4267_RS17905	COG0725	ABC transporter, periplasmic molybdate-binding protein
N4267_RS17910	COG1492	cobalamin metabolic process
N4267_RS17955	COG1917	Cupin 2, conserved barrel domain protein
N4267_RS17955	COG4977	sequence-specific DNA binding
N4267_RS17960	COG4771	TonB-dependent receptor
N4267_RS17965	COG2814	Major facilitator Superfamily
N4267_RS17970	COG2226	methyltransferase
N4267_RS17970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N4267_RS17970	COG3433	isochorismatase activity
N4267_RS17995	COG1021	2,3-dihydroxybenzoate-AMP ligase
N4267_RS18000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N4267_RS18020	COG1132	(ABC) transporter
N4267_RS18025	COG1132	(ABC) transporter
N4267_RS18035	COG5002	protein histidine kinase activity
N4267_RS18035	COG0784	Response regulator, receiver
N4267_RS18040	COG1879	ABC-type sugar transport system periplasmic component
N4267_RS18050	COG2827	Endonuclease containing a URI domain
N4267_RS18055	COG3132	Protein of unknown function, DUF480
N4267_RS18065	COG2926	Belongs to the UPF0265 family
N4267_RS18080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N4267_RS18085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N4267_RS18090	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
N4267_RS18095	COG0247	lactate metabolic process
N4267_RS18100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N4267_RS18105	COG3118	belongs to the thioredoxin family
N4267_RS18130	COG4160	amino acid transport
N4267_RS18135	COG4215	(ABC) transporter
N4267_RS18140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N4267_RS18145	COG1126	abc transporter atp-binding protein
N4267_RS18155	COG2425	protein containing a von Willebrand factor type A (vWA) domain
N4267_RS18165	COG0494	nUDIX hydrolase
N4267_RS18170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
N4267_RS18180	COG1309	transcriptional regulator
N4267_RS18185	COG0513	Belongs to the DEAD box helicase family
N4267_RS18190	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
N4267_RS18195	COG0814	amino acid
N4267_RS18200	COG0840	transmembrane signaling receptor activity
N4267_RS18205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N4267_RS18210	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N4267_RS18220	COG1984	allophanate hydrolase subunit 2
N4267_RS18235	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N4267_RS18240	COG4181	ATPase activity
N4267_RS18250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N4267_RS18255	COG5001	Diguanylate cyclase
N4267_RS18255	COG1716	ATPase activity
N4267_RS18265	COG0484	heat shock protein binding
N4267_RS18280	COG0546	phosphoglycolate phosphatase activity
N4267_RS18295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N4267_RS18305	COG0513	Belongs to the DEAD box helicase family
N4267_RS18320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N4267_RS18330	COG3046	protein related to deoxyribodipyrimidine photolyase
N4267_RS18335	COG3397	chitin binding
N4267_RS18340	COG3227	Zinc metalloprotease (Elastase)
N4267_RS18355	COG1166	arginine decarboxylase activity
N4267_RS18365	COG2239	Acts as a magnesium transporter
N4267_RS18375	COG0527	aspartate kinase activity
N4267_RS18380	COG0662	Cupin 2, conserved barrel domain protein
N4267_RS18385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N4267_RS18390	COG0456	acetyltransferase
N4267_RS18395	COG2154	pterin-4-alpha-carbinolamine dehydratase
N4267_RS18400	COG3186	Phenylalanine-4-hydroxylase
N4267_RS18405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N4267_RS18420	COG2264	protein methyltransferase activity
N4267_RS18445	COG1253	flavin adenine dinucleotide binding
N4267_RS18450	COG1765	OsmC-like protein
N4267_RS18480	COG1252	NADH dehydrogenase
N4267_RS18485	COG0531	amino acid
N4267_RS18500	COG4989	oxidoreductase activity
N4267_RS18505	COG0366	Alpha amylase catalytic
N4267_RS18515	COG2067	long-chain fatty acid transport protein
N4267_RS18520	COG2267	carboxylic ester hydrolase activity
N4267_RS18530	COG0840	transmembrane signaling receptor activity
N4267_RS18535	COG3227	Zinc metalloprotease (Elastase)
N4267_RS18540	COG3047	cAMP biosynthetic process
N4267_RS18550	COG1686	Belongs to the peptidase S11 family
N4267_RS18555	COG0557	exoribonuclease II activity
N4267_RS18560	COG1278	Cold shock
N4267_RS18570	COG3048	D-serine ammonia-lyase activity
N4267_RS18575	COG0583	DNA-binding transcription factor activity
N4267_RS18635	COG0582	viral genome integration into host DNA
N4267_RS18690	COG1278	Cold shock
N4267_RS18695	COG0557	exoribonuclease II activity
N4267_RS18810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N4267_RS18815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N4267_RS18820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N4267_RS18840	COG1278	Cold shock