locus-tag	class	description
F0315_RS00020	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_RS00055	COG4657	Part of a membrane complex involved in electron transport
F0315_RS00060	COG2878	Part of a membrane complex involved in electron transport
F0315_RS00065	COG4656	Part of a membrane complex involved in electron transport
F0315_RS00080	COG4660	Part of a membrane complex involved in electron transport
F0315_RS00085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F0315_RS00090	COG0346	lactoylglutathione lyase activity
F0315_RS00105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0315_RS00110	COG2056	Na+-H+ antiporter family
F0315_RS00115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F0315_RS00120	COG1286	toxin biosynthetic process
F0315_RS00125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
F0315_RS00130	COG0285	dihydrofolate synthase activity
F0315_RS00135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0315_RS00140	COG0101	tRNA pseudouridine synthase activity
F0315_RS00155	COG1263	PTS System
F0315_RS00155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_RS00155	COG2190	(PTS) system
F0315_RS00160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0315_RS00165	COG1940	carbohydrate kinase activity
F0315_RS00165	COG1846	Transcriptional regulator
F0315_RS00170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0315_RS00170	COG4651	solute:proton antiporter activity
F0315_RS00175	COG0367	asparagine synthase
F0315_RS00185	COG3104	oligopeptide transport
F0315_RS00190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0315_RS00195	COG0563	adenylate kinase activity
F0315_RS00200	COG0326	Molecular chaperone. Has ATPase activity
F0315_RS00205	COG3710	Transcriptional regulator
F0315_RS00220	COG0622	Phosphoesterase
F0315_RS00225	COG1090	epimerase
F0315_RS00230	COG0300	oxidoreductase activity
F0315_RS00240	COG3118	belongs to the thioredoxin family
F0315_RS00245	COG0330	HflC and HflK could
F0315_RS00250	COG1585	Membrane protein implicated in regulation of membrane protease activity
F0315_RS00255	COG0789	Transcriptional regulator
F0315_RS00275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0315_RS00280	COG3115	cell septum assembly
F0315_RS00285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
F0315_RS00290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0315_RS00300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_RS00310	COG2190	(PTS) system
F0315_RS00315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0315_RS00320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0315_RS00325	COG1702	phosphate starvation-inducible protein PhoH
F0315_RS00330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0315_RS00335	COG4535	Mg2 and Co2 transporter CorC
F0315_RS00340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F0315_RS00345	COG2888	peptidyl-tyrosine sulfation
F0315_RS00350	COG0495	leucyl-tRNA aminoacylation
F0315_RS00355	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F0315_RS00360	COG1466	dna polymerase III delta subunit
F0315_RS00365	COG0799	negative regulation of ribosome biogenesis
F0315_RS00370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F0315_RS00375	COG0768	penicillin binding
F0315_RS00380	COG0772	Belongs to the SEDS family
F0315_RS00385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0315_RS00390	COG1686	Belongs to the peptidase S11 family
F0315_RS00395	COG2921	Belongs to the UPF0250 family
F0315_RS00400	COG0321	lipoyl(octanoyl) transferase activity
F0315_RS00405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0315_RS00420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0315_RS00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0315_RS00485	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F0315_RS00495	COG0438	transferase activity, transferring glycosyl groups
F0315_RS00505	COG1045	serine acetyltransferase
F0315_RS00525	COG0110	maltose O-acetyltransferase activity
F0315_RS00530	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0315_RS00535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0315_RS00540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0315_RS00545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_RS00585	COG2205	protein histidine kinase activity
F0315_RS00590	COG0745	RESPONSE REGULATOR receiver
F0315_RS00595	COG0366	Alpha amylase catalytic
F0315_RS00600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_RS00600	COG1263	PTS System
F0315_RS00605	COG1609	Transcriptional regulator
F0315_RS00610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0315_RS00615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0315_RS00620	COG2011	ABC-type metal ion transport system permease component
F0315_RS00625	COG1464	Belongs to the NlpA lipoprotein family
F0315_RS00630	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
F0315_RS00640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0315_RS00640	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0315_RS00655	COG1611	Belongs to the LOG family
F0315_RS00660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0315_RS00665	COG2363	Small membrane protein
F0315_RS00670	COG0583	DNA-binding transcription factor activity
F0315_RS00675	COG0301	tRNA thio-modification
F0315_RS00675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0315_RS00685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F0315_RS00690	COG1722	exodeoxyribonuclease VII activity
F0315_RS00695	COG0142	geranyltranstransferase activity
F0315_RS00700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0315_RS00705	COG0564	pseudouridine synthase activity
F0315_RS00735	COG1671	Belongs to the UPF0178 family
F0315_RS00740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0315_RS00745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0315_RS00750	COG0254	rRNA binding
F0315_RS00755	COG1720	tRNA m6t6A37 methyltransferase activity
F0315_RS00760	COG0442	prolyl-tRNA aminoacylation
F0315_RS00780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0315_RS00780	COG0047	phosphoribosylformylglycinamidine synthase activity
F0315_RS00790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F0315_RS00800	COG0583	DNA-binding transcription factor activity
F0315_RS00810	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F0315_RS00815	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0315_RS00850	COG0484	heat shock protein binding
F0315_RS00855	COG0443	Heat shock 70 kDa protein
F0315_RS00865	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F0315_RS00880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0315_RS00885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0315_RS00890	COG0497	DNA recombination
F0315_RS00895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_RS00900	COG2914	Belongs to the UPF0125 (RnfH) family
F0315_RS00905	COG2867	negative regulation of translational initiation
F0315_RS00910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0315_RS00920	COG0582	viral genome integration into host DNA
F0315_RS00950	COG1518	maintenance of DNA repeat elements
F0315_RS00965	COG3501	Rhs element vgr protein
F0315_RS01015	COG2003	Belongs to the UPF0758 family
F0315_RS01050	COG0582	viral genome integration into host DNA
F0315_RS01100	COG0732	type I restriction modification DNA specificity domain
F0315_RS01180	COG1061	Type III restriction enzyme res subunit
F0315_RS01195	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F0315_RS01205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F0315_RS01210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0315_RS01225	COG3051	citrate lyase alpha subunit
F0315_RS01230	COG2301	Belongs to the HpcH HpaI aldolase family
F0315_RS01235	COG3052	prosthetic group binding
F0315_RS01240	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F0315_RS01250	COG3630	sodium ion export across plasma membrane
F0315_RS01255	COG0511	ligase activity, forming carbon-carbon bonds
F0315_RS01255	COG5016	pyruvate
F0315_RS01260	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0315_RS01270	COG4565	transcriptional regulatory protein
F0315_RS01280	COG2200	EAL domain
F0315_RS01290	COG0583	DNA-binding transcription factor activity
F0315_RS01300	COG1115	amino acid carrier protein
F0315_RS01305	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F0315_RS01310	COG0583	DNA-binding transcription factor activity
F0315_RS01315	COG1584	GPR1 FUN34 yaaH family protein
F0315_RS01325	COG0519	Catalyzes the synthesis of GMP from XMP
F0315_RS01325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0315_RS01330	COG0517	IMP dehydrogenase activity
F0315_RS01330	COG0516	GMP reductase activity
F0315_RS01335	COG1570	exodeoxyribonuclease VII activity
F0315_RS01350	COG1160	GTP binding
F0315_RS01355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_RS01360	COG2976	Protein conserved in bacteria
F0315_RS01365	COG0124	histidyl-tRNA synthetase
F0315_RS01370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0315_RS01375	COG1426	Protein conserved in bacteria
F0315_RS01385	COG0105	UTP biosynthetic process
F0315_RS01390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0315_RS01395	COG2975	iron-sulfur cluster assembly
F0315_RS01400	COG0633	Ferredoxin
F0315_RS01410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0315_RS01420	COG0822	iron-sulfur transferase activity
F0315_RS01430	COG1959	2 iron, 2 sulfur cluster binding
F0315_RS01440	COG0483	inositol monophosphate 1-phosphatase activity
F0315_RS01445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_RS01450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_RS01455	COG1862	Preprotein translocase
F0315_RS01470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0315_RS01475	COG0517	IMP dehydrogenase activity
F0315_RS01485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0315_RS01490	COG0583	DNA-binding transcription factor activity
F0315_RS01495	COG0450	alkyl hydroperoxide reductase
F0315_RS01500	COG3142	Participates in the control of copper homeostasis
F0315_RS01515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0315_RS01520	COG0581	inorganic phosphate transmembrane transporter activity
F0315_RS01530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0315_RS01535	COG0248	Ppx GppA phosphatase
F0315_RS01545	COG5002	protein histidine kinase activity
F0315_RS01550	COG0745	RESPONSE REGULATOR receiver
F0315_RS01560	COG0826	peptidase U32
F0315_RS01565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0315_RS01620	COG0542	response to heat
F0315_RS01630	COG0564	pseudouridine synthase activity
F0315_RS01635	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_RS01640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0315_RS01645	COG0077	Prephenate dehydratase
F0315_RS01645	COG1605	Chorismate mutase
F0315_RS01650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0315_RS01655	COG5001	Diguanylate cyclase
F0315_RS01665	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
F0315_RS01675	COG0488	(ABC) transporter
F0315_RS01685	COG0287	Prephenate dehydrogenase
F0315_RS01685	COG1605	Chorismate mutase
F0315_RS01690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0315_RS01695	COG3275	phosphorelay sensor kinase activity
F0315_RS01700	COG3279	Response regulator of the LytR AlgR family
F0315_RS01710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F0315_RS01715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0315_RS01730	COG1966	Carbon starvation protein
F0315_RS01735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0315_RS01740	COG1047	Peptidyl-prolyl cis-trans
F0315_RS01745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0315_RS01755	COG0196	riboflavin kinase activity
F0315_RS01760	COG0728	peptidoglycan biosynthetic process
F0315_RS01765	COG0268	Binds directly to 16S ribosomal RNA
F0315_RS01770	COG0640	Transcriptional regulator
F0315_RS01775	COG0583	DNA-binding transcription factor activity
F0315_RS01780	COG1283	sodium-dependent phosphate transmembrane transporter activity
F0315_RS01785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0315_RS01790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0315_RS01795	COG0730	response to heat
F0315_RS01800	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
F0315_RS01805	COG0494	nUDIX hydrolase
F0315_RS01810	COG3066	DNA modification
F0315_RS01815	COG0667	Aldo Keto reductase
F0315_RS01825	COG2204	response regulator
F0315_RS01830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0315_RS01850	COG0513	Belongs to the DEAD box helicase family
F0315_RS01875	COG3153	acetyltransferase
F0315_RS01880	COG3154	lipid carrier protein
F0315_RS01890	COG0826	peptidase U32
F0315_RS01895	COG0826	peptidase U32
F0315_RS01920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0315_RS01930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0315_RS01935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0315_RS01940	COG0195	Participates in both transcription termination and antitermination
F0315_RS01945	COG0779	Required for maturation of 30S ribosomal subunits
F0315_RS01960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0315_RS01970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0315_RS01975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0315_RS01980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F0315_RS01985	COG1534	Rna-binding protein
F0315_RS01990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0315_RS01995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0315_RS02000	COG2027	D-alanyl-D-alanine carboxypeptidase
F0315_RS02005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0315_RS02010	COG0739	heme binding
F0315_RS02015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_RS02025	COG0316	Belongs to the HesB IscA family
F0315_RS02030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0315_RS02040	COG0628	permease
F0315_RS02045	COG2813	Specifically methylates the guanine in position
F0315_RS02055	COG0747	negative chemotaxis
F0315_RS02065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_RS02070	COG0444	Belongs to the ABC transporter superfamily
F0315_RS02075	COG4608	Belongs to the ABC transporter superfamily
F0315_RS02085	COG2971	BadF BadG BcrA BcrD
F0315_RS02100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0315_RS02105	COG3842	ATPase activity
F0315_RS02115	COG1840	ABC-type Fe3 transport system, periplasmic component
F0315_RS02120	COG0004	ammonium transporteR
F0315_RS02125	COG0347	Belongs to the P(II) protein family
F0315_RS02130	COG3112	Uncharacterised protein family (UPF0231)
F0315_RS02135	COG1049	propionate catabolic process, 2-methylcitrate cycle
F0315_RS02140	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0315_RS02150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0315_RS02155	COG1643	Atp-dependent helicase
F0315_RS02165	COG1489	DNA binding
F0315_RS02175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0315_RS02185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0315_RS02190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0315_RS02195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0315_RS02200	COG0842	Transport permease protein
F0315_RS02205	COG1131	(ABC) transporter
F0315_RS02210	COG0659	secondary active sulfate transmembrane transporter activity
F0315_RS02215	COG0288	reversible hydration of carbon dioxide
F0315_RS02230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F0315_RS02235	COG3107	peptidoglycan biosynthetic process
F0315_RS02240	COG0792	nuclease activity
F0315_RS02245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0315_RS02250	COG2823	Periplasmic or secreted lipoprotein
F0315_RS02255	COG2969	positive regulation of protein catabolic process
F0315_RS02260	COG0625	glutathione transferase activity
F0315_RS02265	COG2857	Cytochrome c1
F0315_RS02270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F0315_RS02275	COG0723	plastoquinol--plastocyanin reductase activity
F0315_RS02280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0315_RS02285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0315_RS02290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F0315_RS02300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0315_RS02305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0315_RS02310	COG0335	large ribosomal subunit rRNA binding
F0315_RS02315	COG0336	Belongs to the RNA methyltransferase TrmD family
F0315_RS02320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0315_RS02325	COG0228	four-way junction DNA binding
F0315_RS02330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0315_RS02335	COG4137	Cytochrome C assembly protein
F0315_RS02340	COG4536	flavin adenine dinucleotide binding
F0315_RS02345	COG1854	S-ribosylhomocysteine lyase activity
F0315_RS02350	COG2918	glutathione biosynthetic process
F0315_RS02355	COG0612	Peptidase, M16
F0315_RS02360	COG1238	metal cluster binding
F0315_RS02370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0315_RS02375	COG0511	ligase activity, forming carbon-carbon bonds
F0315_RS02375	COG5016	pyruvate
F0315_RS02380	COG3630	sodium ion export across plasma membrane
F0315_RS02425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F0315_RS02430	COG0527	aspartate kinase activity
F0315_RS02435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0315_RS02445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0315_RS02450	COG1546	Belongs to the CinA family
F0315_RS02455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F0315_RS02460	COG4208	sulfate ABC transporter
F0315_RS02465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F0315_RS02480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F0315_RS02485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0315_RS02495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0315_RS02500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F0315_RS02505	COG0585	pseudouridine synthase activity
F0315_RS02510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0315_RS02515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0315_RS02520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F0315_RS02525	COG1968	undecaprenyl-diphosphatase activity
F0315_RS02530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0315_RS02535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0315_RS02545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F0315_RS02555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0315_RS02560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F0315_RS02565	COG1610	YqeY-like protein
F0315_RS02570	COG0358	DNA primase activity
F0315_RS02590	COG0582	viral genome integration into host DNA
F0315_RS02620	COG2003	Belongs to the UPF0758 family
F0315_RS02660	COG1479	Protein of unknown function DUF262
F0315_RS02700	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_RS02735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F0315_RS02810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0315_RS02815	COG1349	DNA-binding transcription factor activity
F0315_RS02835	COG1279	arginine transmembrane transporter activity
F0315_RS02840	COG0668	transmembrane transport
F0315_RS02845	COG0191	fructose-bisphosphate aldolase activity
F0315_RS02850	COG0126	phosphoglycerate kinase activity
F0315_RS02855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0315_RS02860	COG4771	TonB-dependent receptor
F0315_RS02865	COG0583	DNA-binding transcription factor activity
F0315_RS02870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0315_RS02875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0315_RS02885	COG2356	endonuclease I
F0315_RS02890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F0315_RS02895	COG0189	ligase activity
F0315_RS02900	COG1678	Uncharacterized ACR, COG1678
F0315_RS02905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0315_RS02910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0315_RS02935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0315_RS02940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0315_RS02945	COG0762	integral membrane protein
F0315_RS02960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F0315_RS02965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0315_RS02970	COG2066	Belongs to the glutaminase family
F0315_RS02975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0315_RS02980	COG1194	a g-specific adenine glycosylase
F0315_RS02985	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F0315_RS02990	COG0741	lytic transglycosylase activity
F0315_RS03045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0315_RS03050	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0315_RS03055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0315_RS03060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0315_RS03065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0315_RS03070	COG2967	ApaG domain
F0315_RS03075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0315_RS03090	COG3610	response to peptide
F0315_RS03095	COG2966	Psort location CytoplasmicMembrane, score
F0315_RS03100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0315_RS03105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0315_RS03110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0315_RS03115	COG0142	geranyltranstransferase activity
F0315_RS03120	COG0531	amino acid
F0315_RS03125	COG0039	L-malate dehydrogenase activity
F0315_RS03130	COG1438	arginine binding
F0315_RS03140	COG2358	TRAP transporter, solute receptor (TAXI family
F0315_RS03150	COG0589	response to stress
F0315_RS03175	COG2235	arginine
F0315_RS03180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0315_RS03190	COG0312	modulator of DNA gyrase
F0315_RS03195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0315_RS03200	COG3164	Protein of unknown function
F0315_RS03210	COG0424	maF-like protein
F0315_RS03215	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F0315_RS03220	COG1792	Involved in formation and maintenance of cell shape
F0315_RS03225	COG1077	Cell shape determining protein MreB Mrl
F0315_RS03260	COG2165	general secretion pathway protein
F0315_RS03270	COG1459	type II secretion system
F0315_RS03275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0315_RS03285	COG3267	Type II secretory pathway component ExeA
F0315_RS03285	COG3409	Peptidoglycan-binding domain 1 protein
F0315_RS03310	COG2199	diguanylate cyclase activity
F0315_RS03310	COG2200	EAL domain
F0315_RS03385	COG0629	single-stranded DNA binding
F0315_RS03400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0315_RS03410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0315_RS03415	COG0527	aspartate kinase activity
F0315_RS03420	COG0646	methionine synthase
F0315_RS03420	COG1410	methionine synthase
F0315_RS03490	COG0175	sulfate reduction
F0315_RS03500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0315_RS03525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0315_RS03530	COG0735	belongs to the Fur family
F0315_RS03545	COG0166	Belongs to the GPI family
F0315_RS03550	COG0432	Pfam Uncharacterised protein family UPF0047
F0315_RS03555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0315_RS03570	COG0359	binds to the 23S rRNA
F0315_RS03575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0315_RS03580	COG2965	DNA replication, synthesis of RNA primer
F0315_RS03585	COG0360	Binds together with S18 to 16S ribosomal RNA
F0315_RS03595	COG2906	2 iron, 2 sulfur cluster binding
F0315_RS03600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0315_RS03605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0315_RS03610	COG0049	tRNA binding
F0315_RS03625	COG2923	Belongs to the DsrF TusC family
F0315_RS03630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F0315_RS03635	COG2964	Protein conserved in bacteria
F0315_RS03640	COG0545	Peptidyl-prolyl cis-trans isomerase
F0315_RS03650	COG2900	Belongs to the SlyX family
F0315_RS03655	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
F0315_RS03660	COG0330	HflC and HflK could
F0315_RS03665	COG0330	HflC and HflK could
F0315_RS03670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0315_RS03675	COG1923	regulation of RNA biosynthetic process
F0315_RS03680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0315_RS03685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F0315_RS03695	COG0802	atpase or kinase
F0315_RS03700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0315_RS03750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F0315_RS03755	COG1162	GTPase activity
F0315_RS03760	COG0688	phosphatidylethanolamine metabolic process
F0315_RS03765	COG0471	metal ion transport
F0315_RS03775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F0315_RS03780	COG4942	peptidase
F0315_RS03795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0315_RS03800	COG2816	NAD+ diphosphatase activity
F0315_RS03805	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
F0315_RS03810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0315_RS03815	COG0085	RNA polymerase activity
F0315_RS03820	COG0222	ribosome binding
F0315_RS03825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0315_RS03835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F0315_RS03840	COG0250	Participates in transcription elongation, termination and antitermination
F0315_RS03845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0315_RS03850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0315_RS03875	COG1072	(Pantothenic acid kinase))
F0315_RS03885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0315_RS03895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0315_RS03935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F0315_RS03950	COG3118	belongs to the thioredoxin family
F0315_RS03955	COG0513	Belongs to the DEAD box helicase family
F0315_RS03960	COG0248	Ppx GppA phosphatase
F0315_RS03965	COG2202	Pas domain
F0315_RS03965	COG2205	protein histidine kinase activity
F0315_RS03970	COG2814	Major facilitator Superfamily
F0315_RS03990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0315_RS03995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0315_RS04000	COG0511	ligase activity, forming carbon-carbon bonds
F0315_RS04005	COG0439	Biotin carboxylase
F0315_RS04020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0315_RS04025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F0315_RS04030	COG1609	Transcriptional regulator
F0315_RS04035	COG0129	dihydroxy-acid dehydratase activity
F0315_RS04040	COG3265	gluconokinase activity
F0315_RS04045	COG2610	gluconate transmembrane transporter activity
F0315_RS04050	COG0800	Aldolase
F0315_RS04055	COG1982	Orn Lys Arg decarboxylase major
F0315_RS04060	COG0531	amino acid
F0315_RS04065	COG3710	Transcriptional regulator
F0315_RS04070	COG0789	Transcriptional regulator
F0315_RS04085	COG0151	Belongs to the GarS family
F0315_RS04095	COG0776	regulation of translation
F0315_RS04100	COG1253	flavin adenine dinucleotide binding
F0315_RS04105	COG3068	Protein conserved in bacteria
F0315_RS04115	COG1573	uracil-dna glycosylase
F0315_RS04120	COG0668	transmembrane transport
F0315_RS04125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F0315_RS04135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0315_RS04145	COG1482	cell wall glycoprotein biosynthetic process
F0315_RS04170	COG0438	transferase activity, transferring glycosyl groups
F0315_RS04185	COG1216	Glycosyl transferase, family 2
F0315_RS04230	COG1596	polysaccharide export
F0315_RS04250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0315_RS04260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0315_RS04280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0315_RS04300	COG2226	methyltransferase
F0315_RS04335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0315_RS04355	COG0859	PFAM glycosyl transferase family 9
F0315_RS04365	COG1519	Transferase
F0315_RS04370	COG0456	acetyltransferase
F0315_RS04375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0315_RS04390	COG3642	lipopolysaccharide core region biosynthetic process
F0315_RS04395	COG0859	PFAM glycosyl transferase family 9
F0315_RS04400	COG0463	Glycosyl transferase, family 2
F0315_RS04405	COG0859	PFAM glycosyl transferase family 9
F0315_RS04410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0315_RS04415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0315_RS04425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0315_RS04430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0315_RS04435	COG2003	Belongs to the UPF0758 family
F0315_RS04445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F0315_RS04455	COG1309	transcriptional regulator
F0315_RS04460	COG1560	Kdo2-lipid A biosynthetic process
F0315_RS04465	COG1560	Kdo2-lipid A biosynthetic process
F0315_RS04470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0315_RS04475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F0315_RS04480	COG1561	YicC-like family, N-terminal region
F0315_RS04485	COG2862	Uncharacterized protein family, UPF0114
F0315_RS04490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_RS04490	COG1263	PTS System
F0315_RS04495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0315_RS04510	COG0514	ATP-dependent DNA helicase (RecQ)
F0315_RS04515	COG2962	Rard protein
F0315_RS04520	COG0405	Gamma-glutamyltransferase
F0315_RS04530	COG1280	lysine exporter protein (LysE YggA)
F0315_RS04535	COG0210	DNA helicase
F0315_RS04545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F0315_RS04550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_RS04590	COG3621	Patatin-like phospholipase
F0315_RS04630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_RS04635	COG0601	transmembrane transport
F0315_RS04640	COG0747	negative chemotaxis
F0315_RS04735	COG4964	Belongs to the GSP D family
F0315_RS04770	COG1309	transcriptional regulator
F0315_RS04775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_RS04780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_RS04785	COG2960	long-chain fatty acid transporting porin activity
F0315_RS04790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0315_RS04795	COG0583	DNA-binding transcription factor activity
F0315_RS04865	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
F0315_RS04870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_RS04875	COG1739	Uncharacterized protein family UPF0029
F0315_RS04880	COG1024	Enoyl-CoA hydratase
F0315_RS04880	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0315_RS04885	COG0183	Belongs to the thiolase family
F0315_RS04890	COG0583	DNA-binding transcription factor activity
F0315_RS04895	COG2814	Major facilitator Superfamily
F0315_RS04905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0315_RS04910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0315_RS04915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0315_RS04920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0315_RS04925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0315_RS04930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0315_RS04940	COG0356	it plays a direct role in the translocation of protons across the membrane
F0315_RS04945	COG3312	ion transport
F0315_RS04950	COG1475	DNA binding
F0315_RS04955	COG1192	Involved in chromosome partitioning
F0315_RS04960	COG0357	Ribosomal RNA small subunit methyltransferase G
F0315_RS04965	COG0445	tRNA wobble uridine modification
F0315_RS04975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0315_RS04980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0315_RS04985	COG0706	membrane insertase activity
F0315_RS04995	COG0594	ribonuclease P activity
F0315_RS05000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0315_RS05005	COG1126	abc transporter atp-binding protein
F0315_RS05020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0315_RS05025	COG0592	DNA-directed DNA polymerase activity
F0315_RS05030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0315_RS05035	COG0187	DNA topoisomerase II activity
F0315_RS05050	COG0071	Belongs to the small heat shock protein (HSP20) family
F0315_RS05055	COG3977	Valine--pyruvate aminotransferase
F0315_RS05060	COG0751	glycine-tRNA ligase activity
F0315_RS05065	COG0752	glycyl-tRNA synthetase alpha subunit
F0315_RS05070	COG2119	membrane
F0315_RS05080	COG0425	Belongs to the sulfur carrier protein TusA family
F0315_RS05090	COG0604	alcohol dehydrogenase
F0315_RS05100	COG0129	dihydroxy-acid dehydratase activity
F0315_RS05105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0315_RS05120	COG0606	chelatase, subunit chli
F0315_RS05125	COG0204	Acyl-transferase
F0315_RS05130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0315_RS05135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F0315_RS05145	COG3084	Protein conserved in bacteria
F0315_RS05155	COG4326	sporulation control protein
F0315_RS05160	COG1272	protein, Hemolysin III
F0315_RS05170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_RS05175	COG0569	domain protein
F0315_RS05180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0315_RS05180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0315_RS05185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0315_RS05190	COG0242	peptide deformylase activity
F0315_RS05195	COG1652	LysM domain
F0315_RS05200	COG0758	DNA mediated transformation
F0315_RS05205	COG2922	Belongs to the Smg family
F0315_RS05210	COG0551	DNA topoisomerase type I activity
F0315_RS05215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F0315_RS05220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0315_RS05225	COG0009	L-threonylcarbamoyladenylate synthase
F0315_RS05230	COG0408	coproporphyrinogen oxidase activity
F0315_RS05235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0315_RS05245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0315_RS05280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0315_RS05285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0315_RS05295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0315_RS05300	COG2104	thiamine diphosphate biosynthetic process
F0315_RS05305	COG2022	thiamine diphosphate biosynthetic process
F0315_RS05310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0315_RS05315	COG0006	proline dipeptidase activity
F0315_RS05315	COG0006	proline dipeptidase activity
F0315_RS05335	COG1522	sequence-specific DNA binding
F0315_RS05340	COG5001	Diguanylate cyclase
F0315_RS05340	COG5002	protein histidine kinase activity
F0315_RS05360	COG0589	response to stress
F0315_RS05365	COG1528	Iron-storage protein
F0315_RS05375	COG2081	HI0933 family
F0315_RS05460	COG0840	transmembrane signaling receptor activity
F0315_RS05470	COG1322	Protein conserved in bacteria
F0315_RS05475	COG2226	methyltransferase
F0315_RS05490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0315_RS05495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0315_RS05500	COG0805	protein transport
F0315_RS05510	COG0534	Mate efflux family protein
F0315_RS05520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0315_RS05530	COG2937	Belongs to the GPAT DAPAT family
F0315_RS05535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F0315_RS05540	COG3161	chorismate lyase activity
F0315_RS05550	COG1580	Controls the rotational direction of flagella during chemotaxis
F0315_RS05560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0315_RS05570	COG0084	hydrolase, TatD family'
F0315_RS05590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0315_RS05590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0315_RS05610	COG3078	GTPase activator activity
F0315_RS05625	COG3071	HemY protein
F0315_RS05630	COG2959	enzyme of heme biosynthesis
F0315_RS05635	COG1587	Uroporphyrinogen-III synthase
F0315_RS05640	COG0181	hydroxymethylbilane synthase activity
F0315_RS05655	COG1965	Belongs to the frataxin family
F0315_RS05665	COG0019	diaminopimelate decarboxylase activity
F0315_RS05670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0315_RS05680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F0315_RS05685	COG1011	Hydrolase
F0315_RS05690	COG3287	FIST C domain
F0315_RS05690	COG2200	EAL domain
F0315_RS05690	COG2199	diguanylate cyclase activity
F0315_RS05705	COG0561	phosphatase activity
F0315_RS05710	COG2267	carboxylic ester hydrolase activity
F0315_RS05715	COG1280	lysine exporter protein (LysE YggA)
F0315_RS05720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F0315_RS05725	COG0783	Belongs to the Dps family
F0315_RS05765	COG0742	ribosomal rna small subunit methyltransferase
F0315_RS05770	COG0552	protein localization to endoplasmic reticulum
F0315_RS05775	COG2884	Cell division ATP-binding protein ftsE
F0315_RS05780	COG2177	Part of the ABC transporter FtsEX involved in
F0315_RS05785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0315_RS05790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_RS05835	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_RS05865	COG1110	DNA topoisomerase II activity
F0315_RS05950	COG2003	Belongs to the UPF0758 family
F0315_RS05955	COG0464	growth
F0315_RS05965	COG3385	transposase activity
F0315_RS05970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0315_RS05990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0315_RS06040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0315_RS06045	COG5001	Diguanylate cyclase
F0315_RS06045	COG3300	MHYT domain
F0315_RS06055	COG3852	Histidine kinase
F0315_RS06065	COG0174	glutamine synthetase
F0315_RS06075	COG1217	gtp-binding protein TYPA
F0315_RS06085	COG1295	ribonuclease BN
F0315_RS06090	COG1490	D-aminoacyl-tRNA deacylase activity
F0315_RS06095	COG0456	acetyltransferase
F0315_RS06105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F0315_RS06110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F0315_RS06115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F0315_RS06120	COG3031	protein transport across the cell outer membrane
F0315_RS06130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0315_RS06135	COG1459	type II secretion system
F0315_RS06140	COG2165	general secretion pathway protein
F0315_RS06145	COG2165	general secretion pathway protein
F0315_RS06150	COG2165	general secretion pathway protein
F0315_RS06155	COG4795	General secretion pathway protein
F0315_RS06160	COG3156	type II secretion system protein K
F0315_RS06165	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F0315_RS06170	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F0315_RS06180	COG1218	3'(2'),5'-bisphosphate nucleotidase
F0315_RS06185	COG0494	nUDIX hydrolase
F0315_RS06195	COG1040	competence protein
F0315_RS06200	COG0596	Alpha beta hydrolase
F0315_RS06210	COG2183	response to ionizing radiation
F0315_RS06215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0315_RS06230	COG1129	ABC transporter
F0315_RS06235	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0315_RS06240	COG1472	Belongs to the glycosyl hydrolase 3 family
F0315_RS06245	COG2199	diguanylate cyclase activity
F0315_RS06260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0315_RS06265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0315_RS06270	COG1758	RNA polymerase activity
F0315_RS06275	COG0194	GDP metabolic process
F0315_RS06280	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F0315_RS06285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0315_RS06305	COG4232	protein-disulfide reductase activity
F0315_RS06315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0315_RS06320	COG1027	Aspartate ammonia-lyase
F0315_RS06325	COG3706	GGDEF domain
F0315_RS06330	COG3030	protein affecting phage T7 exclusion by the F plasmid
F0315_RS06335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F0315_RS06340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F0315_RS06345	COG2205	protein histidine kinase activity
F0315_RS06350	COG0745	RESPONSE REGULATOR receiver
F0315_RS06360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0315_RS06365	COG0205	6-phosphofructokinase activity
F0315_RS06370	COG1494	fructose-1,6-bisphosphatase
F0315_RS06375	COG3074	FtsZ-dependent cytokinesis
F0315_RS06380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F0315_RS06385	COG0460	homoserine dehydrogenase
F0315_RS06385	COG0527	aspartate kinase activity
F0315_RS06390	COG0626	cystathionine gamma-synthase activity
F0315_RS06395	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F0315_RS06400	COG0281	malic enzyme
F0315_RS06405	COG0254	rRNA binding
F0315_RS06410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0315_RS06415	COG1609	Transcriptional regulator
F0315_RS06420	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0315_RS06425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F0315_RS06430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F0315_RS06435	COG1575	Belongs to the MenA family. Type 1 subfamily
F0315_RS06440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0315_RS06445	COG0534	Mate efflux family protein
F0315_RS06450	COG0149	triose-phosphate isomerase activity
F0315_RS06475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0315_RS06480	COG0459	protein refolding
F0315_RS06490	COG1509	lysine 2,3-aminomutase activity
F0315_RS06495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0315_RS06505	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0315_RS06510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0315_RS06515	COG1053	succinate dehydrogenase
F0315_RS06520	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F0315_RS06525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0315_RS06530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F0315_RS06535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0315_RS06545	COG1045	serine acetyltransferase
F0315_RS06555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0315_RS06560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0315_RS06565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0315_RS06570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0315_RS06575	COG0137	argininosuccinate synthase activity
F0315_RS06580	COG0165	Argininosuccinate lyase
F0315_RS06590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_RS06595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0315_RS06595	COG0678	peroxiredoxin activity
F0315_RS06605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0315_RS06635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0315_RS06640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0315_RS06650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F0315_RS06655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0315_RS06660	COG0546	phosphoglycolate phosphatase activity
F0315_RS06665	COG0180	Tryptophanyl-tRNA synthetase
F0315_RS06680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0315_RS06685	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0315_RS06695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0315_RS06705	COG1012	belongs to the aldehyde dehydrogenase family
F0315_RS06720	COG3954	Phosphoribulokinase
F0315_RS06730	COG0429	hydrolase of the alpha beta-hydrolase fold
F0315_RS06740	COG0488	(ABC) transporter
F0315_RS06745	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0315_RS06760	COG1047	Peptidyl-prolyl cis-trans
F0315_RS06770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0315_RS06780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
F0315_RS06785	COG3083	sulfuric ester hydrolase activity
F0315_RS06790	COG0557	exoribonuclease II activity
F0315_RS06795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0315_RS06800	COG0051	transcription antitermination factor activity, RNA binding
F0315_RS06805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0315_RS06810	COG0088	Forms part of the polypeptide exit tunnel
F0315_RS06815	COG0089	rRNA binding
F0315_RS06820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F0315_RS06825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0315_RS06830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0315_RS06835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0315_RS06840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0315_RS06845	COG0255	Belongs to the universal ribosomal protein uL29 family
F0315_RS06850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F0315_RS06855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0315_RS06860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0315_RS06865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0315_RS06870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0315_RS06875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0315_RS06880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0315_RS06885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0315_RS06890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0315_RS06895	COG1841	ribosomal large subunit assembly
F0315_RS06905	COG0201	protein transport
F0315_RS06910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0315_RS06915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0315_RS06920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0315_RS06925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0315_RS06930	COG0202	RNA polymerase activity
F0315_RS06935	COG0203	ribosomal protein L17
F0315_RS06945	COG0545	Peptidyl-prolyl cis-trans isomerase
F0315_RS06950	COG3266	domain, Protein
F0315_RS06950	COG3061	Opacity-associated protein A
F0315_RS06955	COG0697	spore germination
F0315_RS06960	COG2153	protein acetylation
F0315_RS06965	COG0513	Belongs to the DEAD box helicase family
F0315_RS06975	COG0737	Belongs to the 5'-nucleotidase family
F0315_RS06980	COG1648	precorrin-2 dehydrogenase activity
F0315_RS06980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0315_RS06985	COG0175	sulfate reduction
F0315_RS06990	COG2895	sulfate adenylyltransferase (ATP) activity
F0315_RS06995	COG0529	Catalyzes the synthesis of activated sulfate
F0315_RS07015	COG1136	(ABC) transporter
F0315_RS07015	COG0577	efflux transmembrane transporter activity
F0315_RS07030	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F0315_RS07035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_RS07040	COG0729	surface antigen
F0315_RS07050	COG2105	PFAM AIG2 family protein
F0315_RS07055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0315_RS07060	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F0315_RS07070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0315_RS07075	COG0163	prenyltransferase activity
F0315_RS07085	COG1178	ABC-type Fe3 transport system permease component
F0315_RS07090	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F0315_RS07095	COG3028	Belongs to the UPF0307 family
F0315_RS07100	COG0312	modulator of DNA gyrase
F0315_RS07105	COG2239	Acts as a magnesium transporter
F0315_RS07110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_RS07115	COG1660	Displays ATPase and GTPase activities
F0315_RS07120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_RS07125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0315_RS07135	COG1137	ATPase activity
F0315_RS07140	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F0315_RS07155	COG0517	IMP dehydrogenase activity
F0315_RS07155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F0315_RS07170	COG1127	ABC transporter
F0315_RS07175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0315_RS07180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0315_RS07185	COG2854	intermembrane phospholipid transfer
F0315_RS07195	COG5007	Belongs to the BolA IbaG family
F0315_RS07200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0315_RS07205	COG0204	Acyl-transferase
F0315_RS07210	COG0251	oxidation-reduction process
F0315_RS07220	COG0540	Belongs to the ATCase OTCase family
F0315_RS07230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F0315_RS07245	COG0564	pseudouridine synthase activity
F0315_RS07250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0315_RS07255	COG4269	membrane
F0315_RS07265	COG0525	valine-tRNA ligase activity
F0315_RS07270	COG2927	DNA polymerase III (CHI subunit)
F0315_RS07275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0315_RS07280	COG0795	lipopolysaccharide-transporting ATPase activity
F0315_RS07285	COG0795	lipopolysaccharide-transporting ATPase activity
F0315_RS07300	COG3437	response regulator, receiver
F0315_RS07340	COG0066	3-isopropylmalate dehydratase activity
F0315_RS07345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0315_RS07350	COG0473	3-isopropylmalate dehydrogenase activity
F0315_RS07375	COG0583	DNA-binding transcription factor activity
F0315_RS07380	COG1022	Amp-dependent synthetase and ligase
F0315_RS07385	COG0028	Belongs to the TPP enzyme family
F0315_RS07390	COG0440	acetolactate synthase activity
F0315_RS07395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0315_RS07400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0315_RS07405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0315_RS07415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F0315_RS07420	COG3079	Belongs to the UPF0149 family
F0315_RS07425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0315_RS07430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0315_RS07445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F0315_RS07455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0315_RS07465	COG1595	DNA-templated transcription, initiation
F0315_RS07480	COG3086	response to oxidative stress
F0315_RS07485	COG0481	GTPase activity
F0315_RS07495	COG0571	ribonuclease III activity
F0315_RS07500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0315_RS07505	COG1381	Involved in DNA repair and RecF pathway recombination
F0315_RS07510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F0315_RS07515	COG0736	holo-[acyl-carrier-protein] synthase activity
F0315_RS07535	COG3850	Histidine kinase
F0315_RS07535	COG4999	Histidine kinase
F0315_RS07535	COG3437	response regulator, receiver
F0315_RS07535	COG2205	protein histidine kinase activity
F0315_RS07545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0315_RS07550	COG3956	TIGRFAM MazG family protein
F0315_RS07555	COG0504	CTP synthase activity
F0315_RS07560	COG0148	phosphopyruvate hydratase activity
F0315_RS07565	COG0617	tRNA 3'-terminal CCA addition
F0315_RS07570	COG3267	Type II secretory pathway component ExeA
F0315_RS07570	COG3409	Peptidoglycan-binding domain 1 protein
F0315_RS07580	COG4991	sh3 domain protein
F0315_RS07585	COG0306	phosphate transporter
F0315_RS07590	COG1392	Phosphate transport regulator
F0315_RS07595	COG3025	triphosphatase activity
F0315_RS07600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0315_RS07610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0315_RS07615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0315_RS07615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0315_RS07620	COG1538	Outer membrane efflux protein
F0315_RS07625	COG0494	nUDIX hydrolase
F0315_RS07630	COG3151	Protein conserved in bacteria
F0315_RS07640	COG3150	esterase
F0315_RS07645	COG0187	DNA topoisomerase II activity
F0315_RS07650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0315_RS07660	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F0315_RS07665	COG0237	dephospho-CoA kinase activity
F0315_RS07675	COG1459	type II secretion system
F0315_RS07680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0315_RS07690	COG0157	Belongs to the NadC ModD family
F0315_RS07705	COG4974	Belongs to the 'phage' integrase family
F0315_RS07710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0315_RS07715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0315_RS07720	COG0737	Belongs to the 5'-nucleotidase family
F0315_RS07730	COG2186	Transcriptional regulator
F0315_RS07735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0315_RS07740	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0315_RS07745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0315_RS07760	COG3116	cell division
F0315_RS07765	COG0768	penicillin binding
F0315_RS07770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0315_RS07775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0315_RS07785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F0315_RS07790	COG0772	Belongs to the SEDS family
F0315_RS07795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0315_RS07800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0315_RS07805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0315_RS07810	COG0849	cell division
F0315_RS07815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0315_RS07820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F0315_RS07830	COG0653	protein targeting
F0315_RS07835	COG0494	nUDIX hydrolase
F0315_RS07840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0315_RS07850	COG0505	Belongs to the CarA family
F0315_RS07855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0315_RS07875	COG0730	response to heat
F0315_RS07880	COG0583	DNA-binding transcription factor activity
F0315_RS07885	COG2860	membrane
F0315_RS07890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0315_RS07900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0315_RS07910	COG0493	'glutamate synthase
F0315_RS07915	COG0067	glutamate synthase
F0315_RS07915	COG0070	glutamate synthase
F0315_RS07915	COG0069	glutamate synthase activity
F0315_RS07925	COG0070	glutamate synthase
F0315_RS07925	COG0067	glutamate synthase
F0315_RS07925	COG0069	glutamate synthase activity
F0315_RS07930	COG1242	4 iron, 4 sulfur cluster binding
F0315_RS07935	COG3706	GGDEF domain
F0315_RS07935	COG5001	Diguanylate cyclase
F0315_RS07935	COG2203	Gaf domain
F0315_RS07935	COG4251	negative regulation of phosphorylation
F0315_RS07940	COG0784	Response regulator, receiver
F0315_RS07940	COG5002	protein histidine kinase activity
F0315_RS07940	COG2198	Histidine kinase
F0315_RS07945	COG0745	RESPONSE REGULATOR receiver
F0315_RS07955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0315_RS07975	COG0083	homoserine kinase activity
F0315_RS07980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F0315_RS08020	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
F0315_RS08030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0315_RS08035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0315_RS08050	COG1115	amino acid carrier protein
F0315_RS08070	COG3022	response to hydroperoxide
F0315_RS08075	COG0084	hydrolase, TatD family'
F0315_RS08080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0315_RS08090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0315_RS08095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F0315_RS08100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F0315_RS08105	COG0813	purine-nucleoside phosphorylase activity
F0315_RS08115	COG0560	Phosphoserine phosphatase
F0315_RS08125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F0315_RS08130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0315_RS08135	COG1022	Amp-dependent synthetase and ligase
F0315_RS08150	COG3250	beta-galactosidase activity
F0315_RS08160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_RS08175	COG0569	domain protein
F0315_RS08175	COG0189	ligase activity
F0315_RS08180	COG0456	acetyltransferase
F0315_RS08190	COG2171	N-acyltransferase activity
F0315_RS08200	COG3141	response to X-ray
F0315_RS08215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F0315_RS08220	COG1074	ATP-dependent DNA helicase activity
F0315_RS08225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0315_RS08240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F0315_RS08240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0315_RS08250	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F0315_RS08255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F0315_RS08260	COG2166	iron-sulfur cluster assembly
F0315_RS08265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0315_RS08270	COG0693	protein deglycase activity
F0315_RS08275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0315_RS08280	COG3248	Nucleoside-binding outer membrane protein
F0315_RS08290	COG1595	DNA-templated transcription, initiation
F0315_RS08300	COG2211	Major facilitator Superfamily
F0315_RS08310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0315_RS08320	COG2813	Specifically methylates the guanine in position
F0315_RS08325	COG0271	Belongs to the BolA IbaG family
F0315_RS08330	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_RS08335	COG1805	sodium ion transport
F0315_RS08340	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_RS08345	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_RS08350	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0315_RS08355	COG2871	sodium ion transport
F0315_RS08360	COG1477	protein flavinylation
F0315_RS08380	COG3706	GGDEF domain
F0315_RS08385	COG0733	neurotransmitter:sodium symporter activity
F0315_RS08395	COG0189	ligase activity
F0315_RS08400	COG0189	ligase activity
F0315_RS08400	COG4067	protein conserved in archaea
F0315_RS08405	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_RS08410	COG2252	PERMEase
F0315_RS08415	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F0315_RS08420	COG1073	alpha beta
F0315_RS08430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0315_RS08435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0315_RS08440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0315_RS08445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0315_RS08445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0315_RS08460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0315_RS08465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0315_RS08470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F0315_RS08475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F0315_RS08485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0315_RS08490	COG0024	Methionine aminopeptidase
F0315_RS08495	COG0052	Belongs to the universal ribosomal protein uS2 family
F0315_RS08500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0315_RS08505	COG0528	UMP kinase activity
F0315_RS08510	COG0233	cytoplasmic translational termination
F0315_RS08515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0315_RS08520	COG0575	Belongs to the CDS family
F0315_RS08525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0315_RS08530	COG0750	zinc metalloprotease
F0315_RS08540	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
F0315_RS08545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_RS08550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0315_RS08555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_RS08560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_RS08565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0315_RS08570	COG0587	DNA-directed DNA polymerase activity
F0315_RS08575	COG0825	malonyl-CoA metabolic process
F0315_RS08580	COG0037	tRNA processing
F0315_RS08590	COG0347	Belongs to the P(II) protein family
F0315_RS08595	COG3021	interspecies interaction between organisms
F0315_RS08600	COG0741	lytic transglycosylase activity
F0315_RS08600	COG1388	LysM domain
F0315_RS08605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0315_RS08610	COG2226	methyltransferase
F0315_RS08615	COG0328	RNA-DNA hybrid ribonuclease activity
F0315_RS08630	COG1960	acyl-CoA dehydrogenase activity
F0315_RS08635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0315_RS08640	COG0121	glutamine amidotransferase
F0315_RS08645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0315_RS08650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0315_RS08655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0315_RS08660	COG1187	pseudouridine synthase activity
F0315_RS08665	COG2840	Smr protein MutS2
F0315_RS08695	COG2608	mercury ion transmembrane transporter activity
F0315_RS08695	COG2217	Heavy metal translocating P-type atpase
F0315_RS08700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0315_RS08720	COG2375	cellular response to nickel ion
F0315_RS08760	COG0835	chemotaxis
F0315_RS08760	COG0784	Response regulator, receiver
F0315_RS08765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0315_RS08770	COG1815	bacterial-type flagellum-dependent cell motility
F0315_RS08785	COG1749	Flagellar hook protein flgE
F0315_RS08790	COG4787	bacterial-type flagellum-dependent cell motility
F0315_RS08800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F0315_RS08805	COG1706	bacterial-type flagellum-dependent cell motility
F0315_RS08810	COG1705	Flagellar rod assembly protein muramidase FlgJ
F0315_RS08810	COG3951	Flagellar rod assembly protein muramidase FlgJ
F0315_RS08825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_RS08830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_RS08915	COG0012	GTP binding
F0315_RS08920	COG0193	aminoacyl-tRNA hydrolase activity
F0315_RS08925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0315_RS08935	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F0315_RS08940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0315_RS08945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0315_RS08950	COG2890	protein-(glutamine-N5) methyltransferase activity
F0315_RS08960	COG2912	Transglutaminase-like superfamily
F0315_RS08965	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F0315_RS08970	COG0737	Belongs to the 5'-nucleotidase family
F0315_RS08975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0315_RS08980	COG2233	PERMEase
F0315_RS09000	COG1393	Belongs to the ArsC family
F0315_RS09005	COG4783	chaperone-mediated protein folding
F0315_RS09025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F0315_RS09040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
F0315_RS09050	COG1876	peptidase activity
F0315_RS09060	COG1393	Belongs to the ArsC family
F0315_RS09080	COG2837	iron assimilation
F0315_RS09085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_RS09090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_RS09095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0315_RS09100	COG1334	flagellar protein FlaG
F0315_RS09105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F0315_RS09115	COG1516	flagellar protein fliS
F0315_RS09135	COG1677	Flagellar hook-basal body complex protein FliE
F0315_RS09145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F0315_RS09150	COG1317	bacterial-type flagellum organization
F0315_RS09175	COG1580	Controls the rotational direction of flagella during chemotaxis
F0315_RS09200	COG1987	bacterial-type flagellum assembly
F0315_RS09205	COG1684	flagellar biosynthetic protein fliR
F0315_RS09215	COG2840	Smr protein MutS2
F0315_RS09220	COG2890	protein-(glutamine-N5) methyltransferase activity
F0315_RS09225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0315_RS09230	COG2860	membrane
F0315_RS09235	COG3101	peptidyl-lysine hydroxylation
F0315_RS09245	COG0431	NADPH-dependent FMN reductase
F0315_RS09250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F0315_RS09250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0315_RS09255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0315_RS09260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0315_RS09265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0315_RS09270	COG0735	belongs to the Fur family
F0315_RS09280	COG0583	DNA-binding transcription factor activity
F0315_RS09290	COG1346	cytolysis
F0315_RS09305	COG0596	Alpha beta hydrolase
F0315_RS09310	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
F0315_RS09315	COG0033	Phosphoglucomutase
F0315_RS09325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0315_RS09330	COG0372	Belongs to the citrate synthase family
F0315_RS09335	COG2009	succinate dehydrogenase
F0315_RS09340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F0315_RS09345	COG1053	succinate dehydrogenase
F0315_RS09355	COG0567	Dehydrogenase, E1 component
F0315_RS09360	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0315_RS09365	COG0045	succinate-CoA ligase (ADP-forming) activity
F0315_RS09375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0315_RS09380	COG1121	(ABC) transporter
F0315_RS09385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F0315_RS09390	COG4977	sequence-specific DNA binding
F0315_RS09395	COG1918	ferrous iron import across plasma membrane
F0315_RS09415	COG0018	arginyl-trna synthetase
F0315_RS09425	COG1025	Belongs to the peptidase M16 family
F0315_RS09430	COG2062	phosphohistidine phosphatase, SixA
F0315_RS09460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F0315_RS09465	COG0784	Response regulator, receiver
F0315_RS09465	COG2198	Histidine kinase
F0315_RS09465	COG0643	Histidine kinase
F0315_RS09470	COG2201	protein-glutamate methylesterase activity
F0315_RS09475	COG1192	Involved in chromosome partitioning
F0315_RS09485	COG0835	chemotaxis
F0315_RS09495	COG4133	protoheme IX ABC transporter activity
F0315_RS09500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0315_RS09505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0315_RS09515	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F0315_RS09520	COG1138	Cytochrome C-type biogenesis protein
F0315_RS09525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0315_RS09540	COG2853	Lipoprotein
F0315_RS09560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F0315_RS09590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0315_RS09620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F0315_RS09665	COG0123	including yeast histone deacetylase and acetoin utilization protein
F0315_RS09680	COG3083	sulfuric ester hydrolase activity
F0315_RS09685	COG3082	Protein of unknown function (DUF1414)
F0315_RS09690	COG3081	Nucleoid-associated protein
F0315_RS09700	COG1757	Na H antiporter
F0315_RS09705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0315_RS09710	COG2095	MarC family integral membrane protein
F0315_RS09715	COG1012	belongs to the aldehyde dehydrogenase family
F0315_RS09715	COG1454	alcohol dehydrogenase
F0315_RS09730	COG0659	secondary active sulfate transmembrane transporter activity
F0315_RS09735	COG1530	ribonuclease E activity
F0315_RS09750	COG0564	pseudouridine synthase activity
F0315_RS09755	COG0424	maF-like protein
F0315_RS09760	COG1399	metal-binding, possibly nucleic acid-binding protein
F0315_RS09765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0315_RS09770	COG0416	fatty acid biosynthetic process
F0315_RS09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0315_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_RS09790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0315_RS09795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0315_RS09800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0315_RS09805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0315_RS09810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0315_RS09820	COG0084	hydrolase, TatD family'
F0315_RS09825	COG1263	PTS System
F0315_RS09825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_RS09835	COG0733	neurotransmitter:sodium symporter activity
F0315_RS09850	COG4667	esterase of the alpha-beta hydrolase superfamily
F0315_RS09855	COG0469	pyruvate kinase activity
F0315_RS09860	COG1940	carbohydrate kinase activity
F0315_RS09865	COG0835	chemotaxis
F0315_RS09865	COG0784	Response regulator, receiver
F0315_RS09895	COG2226	methyltransferase
F0315_RS09905	COG0676	glucose-6-phosphate 1-epimerase activity
F0315_RS09910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0315_RS09915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_RS09930	COG0252	asparaginase activity
F0315_RS09935	COG0616	signal peptide processing
F0315_RS09940	COG1902	pentaerythritol trinitrate reductase activity
F0315_RS09940	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0315_RS09945	COG0788	formyltetrahydrofolate deformylase activity
F0315_RS09955	COG1199	ATP-dependent helicase activity
F0315_RS09960	COG1214	PFAM Peptidase M22, glycoprotease
F0315_RS09975	COG0596	Alpha beta hydrolase
F0315_RS09980	COG0318	PFAM AMP-dependent synthetase and ligase
F0315_RS09985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F0315_RS10005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F0315_RS10010	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F0315_RS10015	COG0436	Aminotransferase
F0315_RS10020	COG1169	isochorismate synthase
F0315_RS10025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F0315_RS10030	COG0596	Alpha beta hydrolase
F0315_RS10050	COG3135	benzoate transporter
F0315_RS10055	COG1396	sequence-specific DNA binding
F0315_RS10065	COG0477	Major facilitator Superfamily
F0315_RS10085	COG3015	lipoprotein NlpE involved in copper resistance
F0315_RS10090	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F0315_RS10095	COG2894	cell division
F0315_RS10100	COG0850	regulation of cytokinetic process
F0315_RS10105	COG3100	YcgL domain-containing protein
F0315_RS10110	COG2951	lytic endotransglycosylase activity
F0315_RS10125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0315_RS10130	COG3469	chitinase activity
F0315_RS10130	COG3325	Belongs to the glycosyl hydrolase 18 family
F0315_RS10140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0315_RS10175	COG3550	peptidyl-serine autophosphorylation
F0315_RS10205	COG2205	protein histidine kinase activity
F0315_RS10210	COG0745	RESPONSE REGULATOR receiver
F0315_RS10215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_RS10220	COG0569	domain protein
F0315_RS10225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0315_RS10265	COG4264	IucA IucC family
F0315_RS10275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0315_RS10280	COG1120	ATPase activity
F0315_RS10315	COG0671	phosphoesterase, PA-phosphatase related
F0315_RS10330	COG4589	Belongs to the CDS family
F0315_RS10340	COG5001	Diguanylate cyclase
F0315_RS10340	COG3300	MHYT domain
F0315_RS10355	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F0315_RS10360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F0315_RS10365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0315_RS10370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F0315_RS10380	COG4191	Histidine kinase
F0315_RS10390	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0315_RS10400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0315_RS10405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0315_RS10410	COG0776	regulation of translation
F0315_RS10415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0315_RS10420	COG1555	photosystem II stabilization
F0315_RS10425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0315_RS10430	COG0539	negative regulation of cytoplasmic translation
F0315_RS10435	COG0776	regulation of translation
F0315_RS10440	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F0315_RS10445	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F0315_RS10455	COG4174	ABC transporter (Permease)
F0315_RS10460	COG4239	(ABC) transporter, permease
F0315_RS10465	COG0747	negative chemotaxis
F0315_RS10470	COG0444	Belongs to the ABC transporter superfamily
F0315_RS10475	COG4608	Belongs to the ABC transporter superfamily
F0315_RS10500	COG0583	DNA-binding transcription factor activity
F0315_RS10510	COG0686	Belongs to the AlaDH PNT family
F0315_RS10515	COG1522	sequence-specific DNA binding
F0315_RS10520	COG1674	ftsk spoiiie
F0315_RS10525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F0315_RS10530	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0315_RS10535	COG2186	Transcriptional regulator
F0315_RS10545	COG0840	transmembrane signaling receptor activity
F0315_RS10550	COG0537	adenosine 5'-monophosphoramidase activity
F0315_RS10575	COG3150	esterase
F0315_RS10580	COG1252	NADH dehydrogenase
F0315_RS10600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0315_RS10610	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0315_RS10615	COG1136	(ABC) transporter
F0315_RS10620	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0315_RS10630	COG2333	competence protein COMEC
F0315_RS10630	COG0658	competence protein
F0315_RS10635	COG1132	(ABC) transporter
F0315_RS10640	COG1663	tetraacyldisaccharide 4'-kinase activity
F0315_RS10645	COG2835	tetraacyldisaccharide 4'-kinase activity
F0315_RS10650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F0315_RS10685	COG2719	SpoVR family
F0315_RS10690	COG2718	Belongs to the UPF0229 family
F0315_RS10695	COG2766	serine protein kinase
F0315_RS10700	COG3013	Belongs to the UPF0304 family
F0315_RS10710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0315_RS10715	COG0840	transmembrane signaling receptor activity
F0315_RS10760	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
F0315_RS10795	COG0708	Exodeoxyribonuclease III
F0315_RS10800	COG0840	transmembrane signaling receptor activity
F0315_RS10810	COG3923	Primosomal replication protein n
F0315_RS10815	COG0730	response to heat
F0315_RS10820	COG1199	ATP-dependent helicase activity
F0315_RS10830	COG3012	SEC-C Motif Domain Protein
F0315_RS10835	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F0315_RS10840	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0315_RS10845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0315_RS10850	COG0215	cysteine-tRNA ligase activity
F0315_RS10855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0315_RS10860	COG0632	four-way junction helicase activity
F0315_RS10870	COG1271	oxidase subunit
F0315_RS10875	COG1294	oxidase, subunit
F0315_RS10880	COG4890	Cyd operon protein YbgT
F0315_RS10885	COG3790	cyd operon protein YbgE
F0315_RS10890	COG0824	Thioesterase
F0315_RS10895	COG0811	peptide transport
F0315_RS10910	COG0823	Involved in the tonB-independent uptake of proteins
F0315_RS10915	COG2885	chlorophyll binding
F0315_RS10925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0315_RS10935	COG0784	Response regulator, receiver
F0315_RS10935	COG5002	protein histidine kinase activity
F0315_RS10945	COG1012	belongs to the aldehyde dehydrogenase family
F0315_RS10950	COG3284	Transcriptional regulator
F0315_RS10955	COG4628	conserved protein (DUF2132)
F0315_RS10975	COG1940	carbohydrate kinase activity
F0315_RS10990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F0315_RS10995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0315_RS11000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F0315_RS11005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0315_RS11010	COG1737	Transcriptional regulator
F0315_RS11015	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
F0315_RS11040	COG3069	C4-dicarboxylate transmembrane transporter activity
F0315_RS11045	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_RS11055	COG2200	EAL domain
F0315_RS11060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_RS11065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_RS11075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0315_RS11075	COG3008	intermembrane lipid transfer
F0315_RS11080	COG2995	paraquat-inducible protein a
F0315_RS11085	COG0668	transmembrane transport
F0315_RS11095	COG1309	transcriptional regulator
F0315_RS11100	COG1012	belongs to the aldehyde dehydrogenase family
F0315_RS11125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0315_RS11130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0315_RS11140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F0315_RS11160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0315_RS11165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0315_RS11170	COG0297	glycogen (starch) synthase activity
F0315_RS11195	COG3070	regulator of competence-specific genes
F0315_RS11200	COG1609	Transcriptional regulator
F0315_RS11210	COG3381	protein complex oligomerization
F0315_RS11215	COG0745	RESPONSE REGULATOR receiver
F0315_RS11220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0315_RS11225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0315_RS11230	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
F0315_RS11235	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F0315_RS11255	COG1032	radical SAM domain protein
F0315_RS11265	COG0612	Peptidase, M16
F0315_RS11280	COG0583	DNA-binding transcription factor activity
F0315_RS11285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0315_RS11295	COG2350	Protein conserved in bacteria
F0315_RS11300	COG1607	acyl-coa hydrolase
F0315_RS11320	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0315_RS11325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0315_RS11340	COG2116	formate transmembrane transporter activity
F0315_RS11350	COG4459	periplasmic nitrate reductase
F0315_RS11355	COG3005	denitrification pathway
F0315_RS11360	COG0243	molybdopterin cofactor binding
F0315_RS11380	COG1227	inorganic diphosphatase activity
F0315_RS11395	COG4172	Belongs to the ABC transporter superfamily
F0315_RS11410	COG4168	peptide transport system, permease
F0315_RS11420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F0315_RS11425	COG1842	Phage shock protein A
F0315_RS11440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_RS11455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0315_RS11460	COG2818	Glycosylase
F0315_RS11465	COG0626	cystathionine gamma-synthase activity
F0315_RS11475	COG0733	neurotransmitter:sodium symporter activity
F0315_RS11485	COG0564	pseudouridine synthase activity
F0315_RS11490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0315_RS11495	COG4136	ATPase activity
F0315_RS11500	COG4135	transport system, permease component
F0315_RS11505	COG4134	Bacterial extracellular solute-binding protein
F0315_RS11515	COG3313	Fe-S protein
F0315_RS11525	COG0842	Transport permease protein
F0315_RS11530	COG1131	(ABC) transporter
F0315_RS11535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_RS11540	COG0814	amino acid
F0315_RS11550	COG2239	Acts as a magnesium transporter
F0315_RS11555	COG0784	Response regulator, receiver
F0315_RS11555	COG2205	protein histidine kinase activity
F0315_RS11570	COG4934	collagen metabolic process
F0315_RS11605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_RS11620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0315_RS11640	COG1061	Type III restriction enzyme res subunit
F0315_RS11645	COG1187	pseudouridine synthase activity
F0315_RS11650	COG2814	Major facilitator Superfamily
F0315_RS11660	COG0702	epimerase
F0315_RS11665	COG0534	Mate efflux family protein
F0315_RS11670	COG4181	ATPase activity
F0315_RS11675	COG0577	efflux transmembrane transporter activity
F0315_RS11685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0315_RS11700	COG1748	Saccharopine dehydrogenase
F0315_RS11715	COG1538	Outer membrane efflux protein
F0315_RS11800	COG0583	DNA-binding transcription factor activity
F0315_RS11810	COG1451	nucleotide metabolic process
F0315_RS11825	COG3063	Type IV pilus biogenesis stability protein PilW
F0315_RS11830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F0315_RS11850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0315_RS11865	COG3290	protein histidine kinase activity
F0315_RS11870	COG4565	transcriptional regulatory protein
F0315_RS11880	COG0784	Response regulator, receiver
F0315_RS11880	COG0835	chemotaxis
F0315_RS11920	COG1085	galactose-1-phosphate uridylyltransferase
F0315_RS11925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0315_RS11930	COG2017	converts alpha-aldose to the beta-anomer
F0315_RS11940	COG2200	EAL domain
F0315_RS11940	COG2199	diguanylate cyclase activity
F0315_RS11945	COG0753	catalase activity
F0315_RS11955	COG3097	Belongs to the UPF0267 family
F0315_RS12000	COG1271	oxidase subunit
F0315_RS12005	COG1294	oxidase, subunit
F0315_RS12035	COG2723	6-phospho-beta-galactosidase activity
F0315_RS12040	COG1609	Transcriptional regulator
F0315_RS12045	COG0251	oxidation-reduction process
F0315_RS12050	COG2731	YhcH YjgK YiaL family protein
F0315_RS12055	COG0584	glycerophosphoryl diester phosphodiesterase
F0315_RS12060	COG1349	DNA-binding transcription factor activity
F0315_RS12065	COG3842	ATPase activity
F0315_RS12070	COG0395	ABC-type sugar transport system, permease component
F0315_RS12075	COG1175	transmembrane transport
F0315_RS12090	COG0811	peptide transport
F0315_RS12095	COG0811	peptide transport
F0315_RS12100	COG0848	biopolymer transport protein
F0315_RS12105	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0315_RS12115	COG1793	dna ligase
F0315_RS12125	COG0534	Mate efflux family protein
F0315_RS12135	COG3001	Fructosamine kinase
F0315_RS12145	COG0791	NLP P60 protein
F0315_RS12150	COG0840	transmembrane signaling receptor activity
F0315_RS12160	COG3148	PFAM DTW domain containing protein
F0315_RS12165	COG1940	carbohydrate kinase activity
F0315_RS12180	COG0746	molybdenum cofactor guanylyltransferase activity
F0315_RS12185	COG3842	ATPase activity
F0315_RS12190	COG4662	Binding-protein-dependent transport system inner membrane component
F0315_RS12200	COG2204	response regulator
F0315_RS12205	COG3852	Histidine kinase
F0315_RS12210	COG0488	(ABC) transporter
F0315_RS12215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F0315_RS12245	COG0243	molybdopterin cofactor binding
F0315_RS12245	COG3383	formate dehydrogenase (NAD+) activity
F0315_RS12250	COG0437	4 iron, 4 sulfur cluster binding
F0315_RS12265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0315_RS12270	COG1666	GTP binding
F0315_RS12275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0315_RS12290	COG2996	Protein conserved in bacteria
F0315_RS12300	COG3008	intermembrane lipid transfer
F0315_RS12305	COG2995	paraquat-inducible protein a
F0315_RS12310	COG1132	(ABC) transporter
F0315_RS12315	COG1956	GAF domain-containing protein
F0315_RS12320	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F0315_RS12335	COG0308	aminopeptidase N
F0315_RS12350	COG0167	dihydroorotate dehydrogenase activity
F0315_RS12360	COG0116	Belongs to the methyltransferase superfamily
F0315_RS12360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0315_RS12370	COG0488	(ABC) transporter
F0315_RS12385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0315_RS12390	COG1067	ATP-dependent peptidase activity
F0315_RS12395	COG3120	sequence-specific DNA binding
F0315_RS12425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0315_RS12425	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
F0315_RS12470	COG1073	alpha beta
F0315_RS12470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F0315_RS12470	COG3064	Membrane
F0315_RS12475	COG2994	toxin metabolic process
F0315_RS12500	COG3437	response regulator, receiver
F0315_RS12500	COG3850	Histidine kinase
F0315_RS12500	COG4999	Histidine kinase
F0315_RS12500	COG2205	protein histidine kinase activity
F0315_RS12515	COG3278	Belongs to the heme-copper respiratory oxidase family
F0315_RS12530	COG2010	Cytochrome c
F0315_RS12540	COG2217	Heavy metal translocating P-type atpase
F0315_RS12555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0315_RS12560	COG0589	response to stress
F0315_RS12565	COG0037	tRNA processing
F0315_RS12585	COG3842	ATPase activity
F0315_RS12590	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0315_RS12595	COG1177	transmembrane transport
F0315_RS12605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0315_RS12620	COG1115	amino acid carrier protein
F0315_RS12625	COG1280	lysine exporter protein (LysE YggA)
F0315_RS12645	COG3501	Rhs element vgr protein
F0315_RS12655	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F0315_RS12660	COG0513	Belongs to the DEAD box helicase family
F0315_RS12685	COG0477	Major facilitator Superfamily
F0315_RS12690	COG0583	DNA-binding transcription factor activity
F0315_RS12700	COG0402	S-adenosylhomocysteine deaminase activity
F0315_RS12705	COG0095	Lipoate-protein ligase
F0315_RS12710	COG0443	Heat shock 70 kDa protein
F0315_RS12720	COG1643	Atp-dependent helicase
F0315_RS12765	COG0443	Heat shock 70 kDa protein
F0315_RS12770	COG3706	GGDEF domain
F0315_RS12800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F0315_RS12805	COG0602	queuosine metabolic process
F0315_RS12810	COG0561	phosphatase activity
F0315_RS12820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_RS12825	COG4597	amino acid ABC transporter
F0315_RS12830	COG0765	amino acid transport
F0315_RS12835	COG1126	abc transporter atp-binding protein
F0315_RS12840	COG0670	Belongs to the BI1 family
F0315_RS12845	COG2920	part of a sulfur-relay system
F0315_RS12850	COG1254	Belongs to the acylphosphatase family
F0315_RS12855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0315_RS12860	COG3706	GGDEF domain
F0315_RS12875	COG2205	protein histidine kinase activity
F0315_RS12875	COG4999	Histidine kinase
F0315_RS12875	COG3850	Histidine kinase
F0315_RS12875	COG3437	response regulator, receiver
F0315_RS12880	COG3437	response regulator, receiver
F0315_RS12885	COG0625	glutathione transferase activity
F0315_RS12895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F0315_RS12905	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_RS12935	COG0372	Belongs to the citrate synthase family
F0315_RS12940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F0315_RS12950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0315_RS12975	COG1129	ABC transporter
F0315_RS13010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_RS13010	COG4191	Histidine kinase
F0315_RS13015	COG0471	metal ion transport
F0315_RS13025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0315_RS13045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_RS13055	COG3768	UPF0283 membrane protein
F0315_RS13060	COG3106	COG3106 Predicted ATPase
F0315_RS13075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0315_RS13080	COG0494	nUDIX hydrolase
F0315_RS13085	COG0814	amino acid
F0315_RS13090	COG1760	l-serine dehydratase
F0315_RS13095	COG0720	synthase
F0315_RS13105	COG0017	Asparaginyl-tRNA synthetase
F0315_RS13110	COG0351	phosphomethylpyrimidine kinase
F0315_RS13110	COG0352	thiamine-phosphate diphosphorylase activity
F0315_RS13115	COG3437	response regulator, receiver
F0315_RS13115	COG2770	Histidine kinase
F0315_RS13125	COG1448	Aminotransferase
F0315_RS13140	COG0840	transmembrane signaling receptor activity
F0315_RS13145	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F0315_RS13150	COG2943	transferase activity, transferring hexosyl groups
F0315_RS13155	COG1609	Transcriptional regulator
F0315_RS13160	COG3394	polysaccharide catabolic process
F0315_RS13165	COG1486	melibiose metabolic process
F0315_RS13170	COG1447	Phosphotransferase system cellobiose-specific component IIA
F0315_RS13180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0315_RS13185	COG0726	polysaccharide deacetylase
F0315_RS13190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0315_RS13195	COG1846	Transcriptional regulator
F0315_RS13225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F0315_RS13240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0315_RS13245	COG3108	Peptidase M15
F0315_RS13275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0315_RS13285	COG2814	Major facilitator Superfamily
F0315_RS13295	COG1054	Belongs to the UPF0176 family
F0315_RS13300	COG1278	Cold shock
F0315_RS13310	COG3088	subunit of a heme lyase
F0315_RS13310	COG4235	cytochrome complex assembly
F0315_RS13320	COG1138	Cytochrome C-type biogenesis protein
F0315_RS13325	COG3301	Polysulphide reductase, NrfD
F0315_RS13330	COG0437	4 iron, 4 sulfur cluster binding
F0315_RS13340	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F0315_RS13355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0315_RS13360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0315_RS13365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0315_RS13415	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
F0315_RS13420	COG4139	cobalamin transport
F0315_RS13425	COG2988	succinylglutamate desuccinylase activity
F0315_RS13440	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F0315_RS13445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0315_RS13450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_RS13455	COG1823	symporter activity
F0315_RS13460	COG2925	Exonuclease
F0315_RS13465	COG1380	Effector of murein hydrolase LrgA
F0315_RS13470	COG1346	cytolysis
F0315_RS13515	COG0776	regulation of translation
F0315_RS13520	COG0072	phenylalanine-tRNA ligase activity
F0315_RS13520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_RS13525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0315_RS13530	COG0456	acetyltransferase
F0315_RS13565	COG0322	excinuclease ABC activity
F0315_RS13570	COG2197	response regulator
F0315_RS13575	COG0417	DNA replication proofreading
F0315_RS13580	COG5001	Diguanylate cyclase
F0315_RS13590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0315_RS13595	COG3099	Belongs to the UPF0263 family
F0315_RS13610	COG1228	amidohydrolase
F0315_RS13615	COG0010	Belongs to the arginase family
F0315_RS13620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0315_RS13625	COG2986	histidine ammonia-lyase
F0315_RS13645	COG0277	FAD linked oxidase domain protein
F0315_RS13645	COG0247	lactate metabolic process
F0315_RS13665	COG2885	chlorophyll binding
F0315_RS13685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0315_RS13695	COG0281	malic enzyme
F0315_RS13705	COG2949	membrane
F0315_RS13715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0315_RS13725	COG0492	ferredoxin-NADP+ reductase activity
F0315_RS13730	COG4988	ABC transporter
F0315_RS13735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F0315_RS13740	COG1187	pseudouridine synthase activity
F0315_RS13745	COG0009	L-threonylcarbamoyladenylate synthase
F0315_RS13750	COG0613	PHP domain protein
F0315_RS13760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0315_RS13765	COG0512	Glutamine amidotransferase of anthranilate synthase
F0315_RS13770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0315_RS13775	COG0134	indole-3-glycerol-phosphate synthase activity
F0315_RS13775	COG0135	phosphoribosylanthranilate isomerase activity
F0315_RS13780	COG0133	tryptophan synthase activity
F0315_RS13785	COG0159	tryptophan synthase activity
F0315_RS13795	COG1435	thymidine kinase activity
F0315_RS13800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0315_RS13805	COG1801	Protein of unknown function DUF72
F0315_RS13810	COG4106	trans-aconitate 2-methyltransferase activity
F0315_RS13815	COG0500	methyltransferase
F0315_RS13820	COG4067	protein conserved in archaea
F0315_RS13820	COG0189	ligase activity
F0315_RS13835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0315_RS13845	COG3852	Histidine kinase
F0315_RS13860	COG3070	regulator of competence-specific genes
F0315_RS13870	COG2431	L-lysine efflux transmembrane transporter activity
F0315_RS13880	COG0076	glutamate decarboxylase activity
F0315_RS13885	COG1737	Transcriptional regulator
F0315_RS13890	COG1454	alcohol dehydrogenase
F0315_RS13890	COG1012	belongs to the aldehyde dehydrogenase family
F0315_RS13895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0315_RS13900	COG3273	potassium ion transport
F0315_RS13900	COG2985	domain, Protein
F0315_RS13905	COG0542	response to heat
F0315_RS13910	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0315_RS13915	COG1278	Cold shock
F0315_RS13925	COG1187	pseudouridine synthase activity
F0315_RS13930	COG0140	phosphoribosyl-ATP diphosphatase activity
F0315_RS13930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0315_RS13935	COG0107	imidazoleglycerol-phosphate synthase activity
F0315_RS13940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0315_RS13945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0315_RS13950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0315_RS13950	COG0131	Imidazoleglycerol-phosphate dehydratase
F0315_RS13955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0315_RS13960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0315_RS13965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0315_RS13970	COG1757	Na H antiporter
F0315_RS13975	COG2916	Histone family protein nucleoid-structuring protein H-NS
F0315_RS13980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_RS13985	COG0482	sulfurtransferase activity
F0315_RS13990	COG2915	High frequency lysogenization protein hflD homolog
F0315_RS13995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0315_RS14005	COG2268	Band 7 protein
F0315_RS14015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0315_RS14030	COG0300	oxidoreductase activity
F0315_RS14040	COG0501	Belongs to the peptidase M48B family
F0315_RS14050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0315_RS14055	COG2226	methyltransferase
F0315_RS14060	COG0156	8-amino-7-oxononanoate synthase activity
F0315_RS14065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0315_RS14070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F0315_RS14075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0315_RS14080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0315_RS14085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F0315_RS14090	COG0653	protein targeting
F0315_RS14095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0315_RS14100	COG3706	GGDEF domain
F0315_RS14110	COG4120	Belongs to the binding-protein-dependent transport system permease family
F0315_RS14120	COG4628	conserved protein (DUF2132)
F0315_RS14125	COG3092	negative regulation of chromosome organization
F0315_RS14130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0315_RS14135	COG0857	belongs to the CobB CobQ family
F0315_RS14135	COG0280	phosphate acetyltransferase
F0315_RS14140	COG0435	Glutathione S-transferase
F0315_RS14145	COG4608	Belongs to the ABC transporter superfamily
F0315_RS14150	COG0444	Belongs to the ABC transporter superfamily
F0315_RS14155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_RS14160	COG0601	transmembrane transport
F0315_RS14175	COG4191	Histidine kinase
F0315_RS14180	COG2204	response regulator
F0315_RS14185	COG3300	MHYT domain
F0315_RS14185	COG5001	Diguanylate cyclase
F0315_RS14190	COG4191	Histidine kinase
F0315_RS14195	COG5002	protein histidine kinase activity
F0315_RS14205	COG2201	protein-glutamate methylesterase activity
F0315_RS14220	COG0009	L-threonylcarbamoyladenylate synthase
F0315_RS14255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_RS14260	COG3716	PTS system mannose fructose sorbose family IID component
F0315_RS14270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_RS14275	COG2222	sugar isomerase
F0315_RS14285	COG1349	DNA-binding transcription factor activity
F0315_RS14290	COG1349	DNA-binding transcription factor activity
F0315_RS14305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0315_RS14310	COG0640	Transcriptional regulator
F0315_RS14320	COG3706	GGDEF domain
F0315_RS14340	COG1946	Acyl-CoA thioesterase
F0315_RS14345	COG1522	sequence-specific DNA binding
F0315_RS14355	COG0616	signal peptide processing
F0315_RS14360	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_RS14365	COG2983	Belongs to the UPF0260 family
F0315_RS14375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0315_RS14380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0315_RS14385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0315_RS14390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0315_RS14395	COG2832	Protein of unknown function (DUF454)
F0315_RS14405	COG0745	RESPONSE REGULATOR receiver
F0315_RS14410	COG0583	DNA-binding transcription factor activity
F0315_RS14415	COG0778	Nitroreductase
F0315_RS14420	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0315_RS14420	COG1024	Enoyl-CoA hydratase
F0315_RS14425	COG0183	Belongs to the thiolase family
F0315_RS14440	COG2067	long-chain fatty acid transport protein
F0315_RS14450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0315_RS14455	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F0315_RS14460	COG2982	Protein involved in outer membrane biogenesis
F0315_RS14465	COG0572	uridine kinase
F0315_RS14480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_RS14480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0315_RS14495	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F0315_RS14510	COG0617	tRNA 3'-terminal CCA addition
F0315_RS14510	COG0517	IMP dehydrogenase activity
F0315_RS14510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F0315_RS14515	COG2199	diguanylate cyclase activity
F0315_RS14520	COG0314	molybdopterin synthase activity
F0315_RS14525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F0315_RS14530	COG0315	cyclic pyranopterin monophosphate synthase activity
F0315_RS14535	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0315_RS14540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0315_RS14545	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0315_RS14550	COG2198	Histidine kinase
F0315_RS14555	COG2204	response regulator
F0315_RS14565	COG0556	nucleotide-excision repair
F0315_RS14575	COG0582	viral genome integration into host DNA
F0315_RS14600	COG2003	Belongs to the UPF0758 family
F0315_RS14650	COG2831	hemolysin activation secretion protein
F0315_RS14740	COG0494	nUDIX hydrolase
F0315_RS14775	COG0456	acetyltransferase
F0315_RS15120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_RS15160	COG0625	glutathione transferase activity
F0315_RS15175	COG0454	-acetyltransferase
F0315_RS15195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F0315_RS15460	COG0384	phenazine biosynthesis protein PhzF
F0315_RS15510	COG0456	acetyltransferase
F0315_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_RS15580	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F0315_RS15610	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F0315_RS15625	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0315_RS15630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F0315_RS15670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0315_RS15675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0315_RS15685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0315_RS15690	COG0583	DNA-binding transcription factor activity
F0315_RS15700	COG0697	spore germination
F0315_RS15730	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0315_RS15740	COG4804	nuclease activity
F0315_RS15770	COG2916	Histone family protein nucleoid-structuring protein H-NS
F0315_RS15830	COG1518	maintenance of DNA repeat elements
F0315_RS15880	COG3550	peptidyl-serine autophosphorylation
F0315_RS15900	COG0640	Transcriptional regulator
F0315_RS15910	COG2391	methyltransferase activity
F0315_RS15930	COG0778	Nitroreductase
F0315_RS15935	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0315_RS15940	COG0583	DNA-binding transcription factor activity
F0315_RS15960	COG1335	isochorismatase
F0315_RS15975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0315_RS16000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0315_RS16015	COG2390	Transcriptional regulator
F0315_RS16025	COG2897	thiosulfate sulfurtransferase activity
F0315_RS16035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0315_RS16045	COG0302	gtp cyclohydrolase
F0315_RS16050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_RS16050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0315_RS16055	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F0315_RS16060	COG1970	mechanosensitive ion channel activity
F0315_RS16065	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F0315_RS16075	COG1011	Hydrolase
F0315_RS16080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0315_RS16085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0315_RS16090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F0315_RS16095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0315_RS16105	COG3842	ATPase activity
F0315_RS16125	COG3104	oligopeptide transport
F0315_RS16150	COG4166	transmembrane transport
F0315_RS16155	COG4174	ABC transporter (Permease)
F0315_RS16160	COG4239	(ABC) transporter, permease
F0315_RS16165	COG4172	Belongs to the ABC transporter superfamily
F0315_RS16185	COG0625	glutathione transferase activity
F0315_RS16210	COG2050	protein possibly involved in aromatic compounds catabolism
F0315_RS16230	COG0583	DNA-binding transcription factor activity
F0315_RS16235	COG0045	succinate-CoA ligase (ADP-forming) activity
F0315_RS16235	COG1042	CoA-binding domain protein
F0315_RS16235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_RS16255	COG0023	Translation Initiation Factor
F0315_RS16260	COG3140	Belongs to the UPF0181 family
F0315_RS16275	COG0745	RESPONSE REGULATOR receiver
F0315_RS16285	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F0315_RS16290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F0315_RS16305	COG3706	GGDEF domain
F0315_RS16325	COG2199	diguanylate cyclase activity
F0315_RS16365	COG2824	Alkylphosphonate utilization operon protein PhnA
F0315_RS16375	COG0861	Integral membrane protein TerC family
F0315_RS16380	COG0737	Belongs to the 5'-nucleotidase family
F0315_RS16385	COG3593	DNA synthesis involved in DNA repair
F0315_RS16395	COG0583	DNA-binding transcription factor activity
F0315_RS16400	COG2116	formate transmembrane transporter activity
F0315_RS16410	COG3038	cytochrome b561
F0315_RS16420	COG2200	EAL domain
F0315_RS16435	COG0523	cobalamin synthesis protein
F0315_RS16440	COG0038	chloride channel
F0315_RS16450	COG0156	8-amino-7-oxononanoate synthase activity
F0315_RS16455	COG0784	Response regulator, receiver
F0315_RS16455	COG2205	protein histidine kinase activity
F0315_RS16460	COG0419	ATPase involved in DNA repair
F0315_RS16465	COG0420	3'-5' exonuclease activity
F0315_RS16470	COG1609	Transcriptional regulator
F0315_RS16475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_RS16475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_RS16480	COG1105	Belongs to the carbohydrate kinase PfkB family
F0315_RS16485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0315_RS16485	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F0315_RS16485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0315_RS16490	COG0189	ligase activity
F0315_RS16490	COG4067	protein conserved in archaea
F0315_RS16500	COG0602	queuosine metabolic process
F0315_RS16505	COG1328	CTP reductase activity
F0315_RS16540	COG2181	nitrate reductase activity
F0315_RS16545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F0315_RS16550	COG1140	nitrate reductase beta subunit
F0315_RS16555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F0315_RS16560	COG2223	nitrite transmembrane transporter activity
F0315_RS16570	COG2197	response regulator
F0315_RS16630	COG1263	PTS System
F0315_RS16630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_RS16635	COG1609	Transcriptional regulator
F0315_RS16640	COG1621	beta-fructofuranosidase activity
F0315_RS16645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_RS16650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0315_RS16660	COG0545	Peptidyl-prolyl cis-trans isomerase
F0315_RS16665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0315_RS16670	COG0840	transmembrane signaling receptor activity
F0315_RS16675	COG3069	C4-dicarboxylate transmembrane transporter activity
F0315_RS16680	COG1760	l-serine dehydratase
F0315_RS16700	COG1609	Transcriptional regulator
F0315_RS16705	COG2197	response regulator
F0315_RS16710	COG3850	Histidine kinase
F0315_RS16715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0315_RS16750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0315_RS16755	COG2197	response regulator
F0315_RS16760	COG3851	Histidine kinase
F0315_RS16765	COG2271	Major facilitator Superfamily
F0315_RS16770	COG1840	ABC-type Fe3 transport system, periplasmic component
F0315_RS16780	COG3842	ATPase activity
F0315_RS16785	COG3243	poly(R)-hydroxyalkanoic acid synthase
F0315_RS16795	COG0183	Belongs to the thiolase family
F0315_RS16805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_RS16810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0315_RS16830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0315_RS16840	COG1979	alcohol dehydrogenase
F0315_RS16855	COG4191	Histidine kinase
F0315_RS16865	COG2271	Major facilitator Superfamily
F0315_RS16870	COG0469	pyruvate kinase activity
F0315_RS16875	COG0784	Response regulator, receiver
F0315_RS16875	COG2205	protein histidine kinase activity
F0315_RS16875	COG2198	Histidine kinase
F0315_RS16880	COG1879	ABC-type sugar transport system periplasmic component
F0315_RS16885	COG1803	Methylglyoxal synthase
F0315_RS16890	COG1335	isochorismatase
F0315_RS16900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F0315_RS16915	COG0210	DNA helicase
F0315_RS16920	COG1289	transmembrane transporter activity
F0315_RS16950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F0315_RS16955	COG4149	molybdate abc transporter
F0315_RS16960	COG0725	ABC transporter, periplasmic molybdate-binding protein
F0315_RS16965	COG1492	cobalamin metabolic process
F0315_RS16990	COG5002	protein histidine kinase activity
F0315_RS16990	COG0784	Response regulator, receiver
F0315_RS16995	COG1879	ABC-type sugar transport system periplasmic component
F0315_RS17005	COG2827	Endonuclease containing a URI domain
F0315_RS17010	COG3132	Protein of unknown function, DUF480
F0315_RS17020	COG2926	Belongs to the UPF0265 family
F0315_RS17035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0315_RS17040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0315_RS17045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0315_RS17050	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
F0315_RS17055	COG0247	lactate metabolic process
F0315_RS17060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0315_RS17065	COG3118	belongs to the thioredoxin family
F0315_RS17095	COG4160	amino acid transport
F0315_RS17100	COG4215	(ABC) transporter
F0315_RS17105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_RS17110	COG1126	abc transporter atp-binding protein
F0315_RS17120	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0315_RS17130	COG0494	nUDIX hydrolase
F0315_RS17135	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F0315_RS17145	COG1309	transcriptional regulator
F0315_RS17150	COG0513	Belongs to the DEAD box helicase family
F0315_RS17160	COG0814	amino acid
F0315_RS17165	COG0840	transmembrane signaling receptor activity
F0315_RS17170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0315_RS17175	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F0315_RS17180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F0315_RS17185	COG1984	allophanate hydrolase subunit 2
F0315_RS17200	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F0315_RS17205	COG4181	ATPase activity
F0315_RS17215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0315_RS17220	COG1716	ATPase activity
F0315_RS17220	COG5001	Diguanylate cyclase
F0315_RS17230	COG0484	heat shock protein binding
F0315_RS17250	COG0546	phosphoglycolate phosphatase activity
F0315_RS17265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_RS17270	COG1368	sulfuric ester hydrolase activity
F0315_RS17280	COG0513	Belongs to the DEAD box helicase family
F0315_RS17295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0315_RS17305	COG3046	protein related to deoxyribodipyrimidine photolyase
F0315_RS17310	COG3397	chitin binding
F0315_RS17320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0315_RS17345	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0315_RS17360	COG5002	protein histidine kinase activity
F0315_RS17365	COG0745	RESPONSE REGULATOR receiver
F0315_RS17405	COG0561	phosphatase activity
F0315_RS17410	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F0315_RS17415	COG3623	hexulose-6-phosphate isomerase
F0315_RS17430	COG2149	membrane
F0315_RS17440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0315_RS17440	COG1263	PTS System
F0315_RS17445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0315_RS17460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0315_RS17480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0315_RS17500	COG2207	Transcriptional regulator
F0315_RS17505	COG4604	ABC transporter, ATP-binding protein
F0315_RS17510	COG4605	iron ion homeostasis
F0315_RS17515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0315_RS17540	COG0840	transmembrane signaling receptor activity
F0315_RS17550	COG3240	lipase activity
F0315_RS17560	COG2814	Major facilitator Superfamily
F0315_RS17565	COG1757	Na H antiporter
F0315_RS17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_RS17575	COG4191	Histidine kinase
F0315_RS17580	COG0784	Response regulator, receiver
F0315_RS17580	COG3437	response regulator, receiver
F0315_RS17585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0315_RS17590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0315_RS17595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0315_RS17600	COG0513	Belongs to the DEAD box helicase family
F0315_RS17605	COG0516	GMP reductase activity
F0315_RS17625	COG0814	amino acid
F0315_RS17630	COG0488	(ABC) transporter
F0315_RS17635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0315_RS17635	COG1017	nitric oxide dioxygenase activity
F0315_RS17640	COG0242	peptide deformylase activity
F0315_RS17650	COG0579	oxidoreductase
F0315_RS17685	COG2271	Major facilitator Superfamily
F0315_RS17690	COG0584	glycerophosphoryl diester phosphodiesterase
F0315_RS17700	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F0315_RS17710	COG1609	Transcriptional regulator
F0315_RS17715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_RS17720	COG1879	ABC-type sugar transport system periplasmic component
F0315_RS17725	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0315_RS17730	COG1129	ABC transporter
F0315_RS17735	COG1869	D-ribose catabolic process
F0315_RS17755	COG3501	Rhs element vgr protein
F0315_RS17755	COG3409	Peptidoglycan-binding domain 1 protein
F0315_RS17785	COG3829	transcription factor binding
F0315_RS17850	COG0564	pseudouridine synthase activity
F0315_RS17860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0315_RS17865	COG2200	EAL domain
F0315_RS17865	COG2771	luxR family
F0315_RS17875	COG0673	inositol 2-dehydrogenase activity
F0315_RS17880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F0315_RS17915	COG1342	Belongs to the UPF0251 family
F0315_RS17930	COG1301	dicarboxylic acid transport
F0315_RS17935	COG0700	Nucleoside recognition
F0315_RS17940	COG3366	ferrous iron transmembrane transporter activity
F0315_RS17945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F0315_RS17955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0315_RS17960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F0315_RS17965	COG2259	Doxx family
F0315_RS17990	COG0363	glucosamine-6-phosphate deaminase activity
F0315_RS18005	COG4580	involved in the transport of maltose and maltodextrins
F0315_RS18020	COG0840	transmembrane signaling receptor activity
F0315_RS18030	COG0840	transmembrane signaling receptor activity
F0315_RS18045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0315_RS18055	COG0513	Belongs to the DEAD box helicase family
F0315_RS18070	COG2186	Transcriptional regulator
F0315_RS18080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0315_RS18090	COG0246	Mannitol dehydrogenase
F0315_RS18095	COG1904	glucuronate isomerase
F0315_RS18100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_RS18105	COG0800	Aldolase
F0315_RS18120	COG1132	(ABC) transporter
F0315_RS18130	COG1902	pentaerythritol trinitrate reductase activity
F0315_RS18140	COG1280	lysine exporter protein (LysE YggA)
F0315_RS18145	COG2207	Transcriptional regulator
F0315_RS18165	COG1846	Transcriptional regulator
F0315_RS18170	COG1764	response to oxidative stress
F0315_RS18175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0315_RS18180	COG0697	spore germination
F0315_RS18200	COG2814	Major facilitator Superfamily
F0315_RS18205	COG0583	DNA-binding transcription factor activity
F0315_RS18210	COG3706	GGDEF domain
F0315_RS18210	COG2203	Gaf domain
F0315_RS18210	COG5001	Diguanylate cyclase
F0315_RS18210	COG4251	negative regulation of phosphorylation
F0315_RS18215	COG0739	heme binding
F0315_RS18230	COG0659	secondary active sulfate transmembrane transporter activity
F0315_RS18235	COG3314	Sporulation integral membrane protein YlbJ
F0315_RS18255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0315_RS18260	COG0581	inorganic phosphate transmembrane transporter activity
F0315_RS18265	COG0573	inorganic phosphate transmembrane transporter activity
F0315_RS18270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0315_RS18300	COG1770	oligopeptidase
F0315_RS18305	COG0513	Belongs to the DEAD box helicase family
F0315_RS18315	COG1388	LysM domain
F0315_RS18315	COG1376	ErfK ybiS ycfS ynhG family protein
F0315_RS18320	COG0415	Belongs to the DNA photolyase family
F0315_RS18330	COG3272	Protein of unknown function (DUF1722)
F0315_RS18335	COG0813	purine-nucleoside phosphorylase activity
F0315_RS18370	COG0786	glutamate:sodium symporter activity
F0315_RS18390	COG1999	signal sequence binding
F0315_RS18400	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F0315_RS18405	COG0671	phosphoesterase, PA-phosphatase related
F0315_RS18445	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
F0315_RS18450	COG0471	metal ion transport
F0315_RS18485	COG3501	Rhs element vgr protein
F0315_RS18495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0315_RS18500	COG1640	4-alpha-glucanotransferase
F0315_RS18505	COG0058	SHG alpha-glucan phosphorylase activity
F0315_RS18510	COG2909	trisaccharide binding
F0315_RS18525	COG2084	Dehydrogenase
F0315_RS18530	COG0217	transcriptional regulatory protein
F0315_RS18545	COG0444	Belongs to the ABC transporter superfamily
F0315_RS18550	COG4608	Belongs to the ABC transporter superfamily
F0315_RS18580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0315_RS18585	COG1444	tRNA N-acetyltransferase activity
F0315_RS18620	COG0642	Histidine kinase
F0315_RS18625	COG2194	sulfuric ester hydrolase activity
F0315_RS18635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_RS18640	COG0601	transmembrane transport
F0315_RS18665	COG0835	chemotaxis
F0315_RS18670	COG0835	chemotaxis
F0315_RS18675	COG0840	transmembrane signaling receptor activity
F0315_RS18680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0315_RS18705	COG0745	RESPONSE REGULATOR receiver
F0315_RS18710	COG0434	BtpA family
F0315_RS18715	COG1879	ABC-type sugar transport system periplasmic component
F0315_RS18720	COG1129	ABC transporter
F0315_RS18725	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0315_RS18740	COG1070	Carbohydrate kinase
F0315_RS18745	COG1349	DNA-binding transcription factor activity
F0315_RS18760	COG2274	protein secretion by the type I secretion system
F0315_RS18790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0315_RS18815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0315_RS18845	COG2409	Drug exporters of the RND superfamily
F0315_RS18850	COG2197	response regulator
F0315_RS18860	COG1982	Orn Lys Arg decarboxylase major
F0315_RS18865	COG0531	amino acid
F0315_RS18885	COG1901	pseudouridine methyltransferase
F0315_RS18895	COG4221	oxidoreductase activity
F0315_RS18910	COG2910	NAD(P)H-binding
F0315_RS18920	COG0604	alcohol dehydrogenase
F0315_RS18930	COG0655	NAD(P)H dehydrogenase (quinone) activity
F0315_RS18935	COG0583	DNA-binding transcription factor activity
F0315_RS18950	COG0697	spore germination
F0315_RS18975	COG0673	inositol 2-dehydrogenase activity
F0315_RS18980	COG3722	fumarate hydratase activity
F0315_RS18985	COG0246	Mannitol dehydrogenase
F0315_RS18990	COG2213	PTS system mannitol-specific
F0315_RS18990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0315_RS18995	COG3385	transposase activity
F0315_RS19000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0315_RS19005	COG4597	amino acid ABC transporter
F0315_RS19010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0315_RS19020	COG1126	abc transporter atp-binding protein
F0315_RS19025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0315_RS19035	COG0840	transmembrane signaling receptor activity
F0315_RS19050	COG1620	l-lactate permease
F0315_RS19055	COG0583	DNA-binding transcription factor activity
F0315_RS19060	COG4172	Belongs to the ABC transporter superfamily
F0315_RS19070	COG1067	ATP-dependent peptidase activity
F0315_RS19085	COG2211	Major facilitator Superfamily
F0315_RS19095	COG3123	guanosine phosphorylase activity
F0315_RS19100	COG1741	Belongs to the pirin family
F0315_RS19115	COG0583	DNA-binding transcription factor activity
F0315_RS19150	COG3706	GGDEF domain
F0315_RS19155	COG1846	Transcriptional regulator
F0315_RS19160	COG0835	chemotaxis
F0315_RS19160	COG0784	Response regulator, receiver
F0315_RS19165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0315_RS19175	COG0393	Putative heavy-metal-binding
F0315_RS19190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0315_RS19195	COG3842	ATPase activity
F0315_RS19205	COG1175	transmembrane transport
F0315_RS19210	COG3833	ABC-type maltose transport systems, permease component
F0315_RS19225	COG1349	DNA-binding transcription factor activity
F0315_RS19230	COG2199	diguanylate cyclase activity
F0315_RS19255	COG1278	Cold shock
F0315_RS19260	COG2354	Protein conserved in bacteria
F0315_RS19265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0315_RS19270	COG0418	dihydroorotase activity
F0315_RS19275	COG0633	Ferredoxin
F0315_RS19275	COG3217	Mosc domain protein beta barrel domain protein
F0315_RS19275	COG0633	Ferredoxin
F0315_RS19275	COG3217	Mosc domain protein beta barrel domain protein
F0315_RS19310	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0315_RS19315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0315_RS19320	COG4558	Periplasmic binding protein
F0315_RS19325	COG0848	biopolymer transport protein
F0315_RS19330	COG0811	peptide transport
F0315_RS19335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0315_RS19345	COG3721	Heme iron utilization protein
F0315_RS19350	COG0748	coenzyme F420 binding
F0315_RS19360	COG1858	cytochrome C peroxidase
F0315_RS19365	COG3835	regulator
F0315_RS19370	COG2610	gluconate transmembrane transporter activity
F0315_RS19375	COG1929	Belongs to the glycerate kinase type-1 family
F0315_RS19400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0315_RS19405	COG0363	glucosamine-6-phosphate deaminase activity
F0315_RS19410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F0315_RS19415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0315_RS19435	COG0346	lactoylglutathione lyase activity
F0315_RS19445	COG2873	o-acetylhomoserine
F0315_RS19455	COG1063	alcohol dehydrogenase
F0315_RS19475	COG0582	viral genome integration into host DNA
F0315_RS19505	COG1802	Transcriptional regulator
F0315_RS19505	COG4626	Terminase
F0315_RS19650	COG3833	ABC-type maltose transport systems, permease component
F0315_RS19655	COG3842	ATPase activity
F0315_RS19660	COG0584	glycerophosphoryl diester phosphodiesterase
F0315_RS19710	COG1063	alcohol dehydrogenase
F0315_RS19720	COG1278	Cold shock
F0315_RS19725	COG0557	exoribonuclease II activity
F0315_RS19730	COG1686	Belongs to the peptidase S11 family
F0315_RS19740	COG3047	cAMP biosynthetic process
F0315_RS19760	COG3530	Putative quorum-sensing-regulated virulence factor
F0315_RS19770	COG5001	Diguanylate cyclase
F0315_RS19770	COG5002	protein histidine kinase activity
F0315_RS19775	COG1278	Cold shock
F0315_RS19795	COG2304	oxidoreductase activity
F0315_RS19815	COG0714	Associated with various cellular activities
F0315_RS19820	COG0840	transmembrane signaling receptor activity
F0315_RS19835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0315_RS19840	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0315_RS19850	COG3604	Transcriptional regulator
F0315_RS19855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0315_RS19855	COG1017	nitric oxide dioxygenase activity
F0315_RS19860	COG1278	Cold shock
F0315_RS19865	COG3036	rescue of stalled ribosome
F0315_RS19890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F0315_RS19890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0315_RS19895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0315_RS19905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0315_RS19915	COG3227	Zinc metalloprotease (Elastase)
F0315_RS19920	COG0366	Alpha amylase catalytic
F0315_RS19925	COG4989	oxidoreductase activity
F0315_RS19935	COG1136	(ABC) transporter
F0315_RS19940	COG0577	efflux transmembrane transporter activity
F0315_RS19940	COG1136	(ABC) transporter
F0315_RS19955	COG3275	phosphorelay sensor kinase activity
F0315_RS19960	COG3279	Response regulator of the LytR AlgR family
F0315_RS19975	COG0531	amino acid
F0315_RS20000	COG1765	OsmC-like protein
F0315_RS20005	COG1253	flavin adenine dinucleotide binding
F0315_RS20025	COG2264	protein methyltransferase activity
F0315_RS20040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0315_RS20045	COG3186	Phenylalanine-4-hydroxylase
F0315_RS20050	COG2154	pterin-4-alpha-carbinolamine dehydratase
F0315_RS20060	COG0534	Mate efflux family protein
F0315_RS20070	COG2239	Acts as a magnesium transporter
F0315_RS20080	COG1166	arginine decarboxylase activity
F0315_RS20100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0315_RS20105	COG0800	Aldolase
F0315_RS20110	COG1085	galactose-1-phosphate uridylyltransferase
F0315_RS20115	COG1028	Short-chain dehydrogenase reductase Sdr
F0315_RS20135	COG2199	diguanylate cyclase activity
F0315_RS20140	COG3119	arylsulfatase activity
F0315_RS20145	COG3119	arylsulfatase activity
F0315_RS20150	COG0641	radical SAM
F0315_RS20165	COG0601	transmembrane transport
F0315_RS20170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0315_RS20180	COG1414	Transcriptional regulator
F0315_RS20195	COG1686	Belongs to the peptidase S11 family
F0315_RS20210	COG3338	carbonate dehydratase activity
F0315_RS20215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0315_RS20215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0315_RS20220	COG0509	glycine decarboxylation via glycine cleavage system
F0315_RS20225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0315_RS20235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0315_RS20250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0315_RS20255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0315_RS20270	COG0454	-acetyltransferase
F0315_RS20315	COG0456	acetyltransferase
F0315_RS20420	COG0494	nUDIX hydrolase
F0315_RS20465	COG0456	acetyltransferase