locus-tag	class	description
F0316_RS00040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0316_RS00045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0316_RS00055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0316_RS00060	COG2104	thiamine diphosphate biosynthetic process
F0316_RS00065	COG2022	thiamine diphosphate biosynthetic process
F0316_RS00070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0316_RS00075	COG0006	proline dipeptidase activity
F0316_RS00075	COG0006	proline dipeptidase activity
F0316_RS00095	COG1522	sequence-specific DNA binding
F0316_RS00100	COG5001	Diguanylate cyclase
F0316_RS00100	COG5002	protein histidine kinase activity
F0316_RS00120	COG0589	response to stress
F0316_RS00130	COG1528	Iron-storage protein
F0316_RS00140	COG2081	HI0933 family
F0316_RS00150	COG1322	Protein conserved in bacteria
F0316_RS00155	COG2226	methyltransferase
F0316_RS00170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0316_RS00175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0316_RS00180	COG0805	protein transport
F0316_RS00185	COG0534	Mate efflux family protein
F0316_RS00195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0316_RS00205	COG2937	Belongs to the GPAT DAPAT family
F0316_RS00210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F0316_RS00215	COG3161	chorismate lyase activity
F0316_RS00225	COG1580	Controls the rotational direction of flagella during chemotaxis
F0316_RS00230	COG0840	transmembrane signaling receptor activity
F0316_RS00240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0316_RS00250	COG0084	hydrolase, TatD family'
F0316_RS00265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0316_RS00265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0316_RS00285	COG3078	GTPase activator activity
F0316_RS00300	COG3071	HemY protein
F0316_RS00305	COG2959	enzyme of heme biosynthesis
F0316_RS00310	COG1587	Uroporphyrinogen-III synthase
F0316_RS00315	COG0181	hydroxymethylbilane synthase activity
F0316_RS00330	COG1965	Belongs to the frataxin family
F0316_RS00340	COG0019	diaminopimelate decarboxylase activity
F0316_RS00345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0316_RS00355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F0316_RS00360	COG1011	Hydrolase
F0316_RS00365	COG3287	FIST C domain
F0316_RS00365	COG2200	EAL domain
F0316_RS00365	COG2199	diguanylate cyclase activity
F0316_RS00385	COG0561	phosphatase activity
F0316_RS00390	COG2267	carboxylic ester hydrolase activity
F0316_RS00395	COG1280	lysine exporter protein (LysE YggA)
F0316_RS00400	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F0316_RS00405	COG0783	Belongs to the Dps family
F0316_RS00445	COG0742	ribosomal rna small subunit methyltransferase
F0316_RS00450	COG0552	protein localization to endoplasmic reticulum
F0316_RS00455	COG2884	Cell division ATP-binding protein ftsE
F0316_RS00460	COG2177	Part of the ABC transporter FtsEX involved in
F0316_RS00465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0316_RS00470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0316_RS00485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0316_RS00500	COG1404	Belongs to the peptidase S8 family
F0316_RS00505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0316_RS00575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0316_RS00580	COG5001	Diguanylate cyclase
F0316_RS00580	COG3300	MHYT domain
F0316_RS00590	COG3852	Histidine kinase
F0316_RS00600	COG0174	glutamine synthetase
F0316_RS00610	COG1217	gtp-binding protein TYPA
F0316_RS00615	COG1660	Displays ATPase and GTPase activities
F0316_RS00620	COG1295	ribonuclease BN
F0316_RS00625	COG1490	D-aminoacyl-tRNA deacylase activity
F0316_RS00630	COG0456	acetyltransferase
F0316_RS00640	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F0316_RS00645	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F0316_RS00650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F0316_RS00655	COG3031	protein transport across the cell outer membrane
F0316_RS00665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0316_RS00670	COG1459	type II secretion system
F0316_RS00675	COG2165	general secretion pathway protein
F0316_RS00680	COG2165	general secretion pathway protein
F0316_RS00685	COG2165	general secretion pathway protein
F0316_RS00690	COG4795	General secretion pathway protein
F0316_RS00695	COG3156	type II secretion system protein K
F0316_RS00700	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F0316_RS00705	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
F0316_RS00715	COG1218	3'(2'),5'-bisphosphate nucleotidase
F0316_RS00720	COG0494	nUDIX hydrolase
F0316_RS00730	COG1040	competence protein
F0316_RS00735	COG0596	Alpha beta hydrolase
F0316_RS00745	COG2183	response to ionizing radiation
F0316_RS00750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0316_RS00755	COG2199	diguanylate cyclase activity
F0316_RS00770	COG2233	PERMEase
F0316_RS00775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0316_RS00780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0316_RS00785	COG1758	RNA polymerase activity
F0316_RS00790	COG0194	GDP metabolic process
F0316_RS00795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F0316_RS00800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0316_RS00820	COG4232	protein-disulfide reductase activity
F0316_RS00830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0316_RS00835	COG1027	Aspartate ammonia-lyase
F0316_RS00840	COG3706	GGDEF domain
F0316_RS00845	COG3030	protein affecting phage T7 exclusion by the F plasmid
F0316_RS00850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F0316_RS00860	COG2205	protein histidine kinase activity
F0316_RS00865	COG0745	RESPONSE REGULATOR receiver
F0316_RS00875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0316_RS00880	COG0205	6-phosphofructokinase activity
F0316_RS00885	COG1494	fructose-1,6-bisphosphatase
F0316_RS00890	COG3074	FtsZ-dependent cytokinesis
F0316_RS00895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F0316_RS00900	COG0527	aspartate kinase activity
F0316_RS00900	COG0460	homoserine dehydrogenase
F0316_RS00905	COG0626	cystathionine gamma-synthase activity
F0316_RS00910	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F0316_RS00915	COG0281	malic enzyme
F0316_RS00920	COG0254	rRNA binding
F0316_RS00925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0316_RS00930	COG1609	Transcriptional regulator
F0316_RS00935	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0316_RS00940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F0316_RS00945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F0316_RS00950	COG1575	Belongs to the MenA family. Type 1 subfamily
F0316_RS00955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0316_RS00960	COG0534	Mate efflux family protein
F0316_RS00965	COG0149	triose-phosphate isomerase activity
F0316_RS00995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0316_RS01000	COG0459	protein refolding
F0316_RS01010	COG1509	lysine 2,3-aminomutase activity
F0316_RS01015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0316_RS01025	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0316_RS01030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0316_RS01035	COG1053	succinate dehydrogenase
F0316_RS01040	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F0316_RS01045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0316_RS01050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F0316_RS01055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0316_RS01060	COG1045	serine acetyltransferase
F0316_RS01070	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0316_RS01075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0316_RS01080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0316_RS01085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0316_RS01090	COG0137	argininosuccinate synthase activity
F0316_RS01095	COG0165	Argininosuccinate lyase
F0316_RS01105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0316_RS01110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0316_RS01110	COG0678	peroxiredoxin activity
F0316_RS01120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0316_RS01150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0316_RS01155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0316_RS01165	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F0316_RS01170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0316_RS01175	COG0546	phosphoglycolate phosphatase activity
F0316_RS01180	COG0180	Tryptophanyl-tRNA synthetase
F0316_RS01195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0316_RS01205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0316_RS01230	COG3954	Phosphoribulokinase
F0316_RS01240	COG0429	hydrolase of the alpha beta-hydrolase fold
F0316_RS01250	COG0488	(ABC) transporter
F0316_RS01255	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0316_RS01270	COG1047	Peptidyl-prolyl cis-trans
F0316_RS01280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0316_RS01290	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
F0316_RS01295	COG3083	sulfuric ester hydrolase activity
F0316_RS01300	COG0557	exoribonuclease II activity
F0316_RS01305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0316_RS01310	COG0051	transcription antitermination factor activity, RNA binding
F0316_RS01315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0316_RS01320	COG0088	Forms part of the polypeptide exit tunnel
F0316_RS01325	COG0089	rRNA binding
F0316_RS01330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F0316_RS01335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0316_RS01340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0316_RS01345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0316_RS01350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0316_RS01355	COG0255	Belongs to the universal ribosomal protein uL29 family
F0316_RS01360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F0316_RS01365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0316_RS01370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0316_RS01375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0316_RS01380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0316_RS01385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0316_RS01395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0316_RS01400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0316_RS01405	COG1841	ribosomal large subunit assembly
F0316_RS01415	COG0201	protein transport
F0316_RS01420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0316_RS01425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0316_RS01430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0316_RS01435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0316_RS01440	COG0202	RNA polymerase activity
F0316_RS01445	COG0203	ribosomal protein L17
F0316_RS01455	COG0545	Peptidyl-prolyl cis-trans isomerase
F0316_RS01460	COG3061	Opacity-associated protein A
F0316_RS01460	COG3266	domain, Protein
F0316_RS01465	COG0697	spore germination
F0316_RS01470	COG2153	protein acetylation
F0316_RS01475	COG0513	Belongs to the DEAD box helicase family
F0316_RS01485	COG0737	Belongs to the 5'-nucleotidase family
F0316_RS01490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0316_RS01490	COG1648	precorrin-2 dehydrogenase activity
F0316_RS01495	COG0175	sulfate reduction
F0316_RS01500	COG2895	sulfate adenylyltransferase (ATP) activity
F0316_RS01505	COG0529	Catalyzes the synthesis of activated sulfate
F0316_RS01525	COG1136	(ABC) transporter
F0316_RS01540	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F0316_RS01545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0316_RS01550	COG0729	surface antigen
F0316_RS01560	COG2105	PFAM AIG2 family protein
F0316_RS01565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0316_RS01580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0316_RS01585	COG0163	prenyltransferase activity
F0316_RS01595	COG1178	ABC-type Fe3 transport system permease component
F0316_RS01600	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F0316_RS01605	COG3028	Belongs to the UPF0307 family
F0316_RS01610	COG0312	modulator of DNA gyrase
F0316_RS01615	COG2239	Acts as a magnesium transporter
F0316_RS01620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0316_RS01625	COG1660	Displays ATPase and GTPase activities
F0316_RS01630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0316_RS01635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0316_RS01645	COG1137	ATPase activity
F0316_RS01650	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F0316_RS01665	COG0517	IMP dehydrogenase activity
F0316_RS01665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F0316_RS01680	COG1127	ABC transporter
F0316_RS01685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0316_RS01690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0316_RS01695	COG2854	intermembrane phospholipid transfer
F0316_RS01705	COG5007	Belongs to the BolA IbaG family
F0316_RS01710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0316_RS01720	COG0251	oxidation-reduction process
F0316_RS01730	COG0540	Belongs to the ATCase OTCase family
F0316_RS01740	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F0316_RS01755	COG0564	pseudouridine synthase activity
F0316_RS01760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0316_RS01765	COG0525	valine-tRNA ligase activity
F0316_RS01770	COG2927	DNA polymerase III (CHI subunit)
F0316_RS01775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0316_RS01780	COG0795	lipopolysaccharide-transporting ATPase activity
F0316_RS01785	COG0795	lipopolysaccharide-transporting ATPase activity
F0316_RS01800	COG3437	response regulator, receiver
F0316_RS01845	COG0066	3-isopropylmalate dehydratase activity
F0316_RS01850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0316_RS01855	COG0473	3-isopropylmalate dehydrogenase activity
F0316_RS01880	COG0583	DNA-binding transcription factor activity
F0316_RS01885	COG1022	Amp-dependent synthetase and ligase
F0316_RS01890	COG0028	Belongs to the TPP enzyme family
F0316_RS01895	COG0440	acetolactate synthase activity
F0316_RS01900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0316_RS01905	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0316_RS01910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0316_RS01920	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F0316_RS01925	COG3079	Belongs to the UPF0149 family
F0316_RS01930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0316_RS01935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0316_RS01945	COG0354	folic acid binding
F0316_RS01950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F0316_RS01960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0316_RS01970	COG1595	DNA-templated transcription, initiation
F0316_RS01985	COG3086	response to oxidative stress
F0316_RS01990	COG0481	GTPase activity
F0316_RS02000	COG0571	ribonuclease III activity
F0316_RS02005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0316_RS02010	COG1381	Involved in DNA repair and RecF pathway recombination
F0316_RS02015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F0316_RS02045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0316_RS02050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0316_RS02055	COG3956	TIGRFAM MazG family protein
F0316_RS02060	COG0504	CTP synthase activity
F0316_RS02065	COG0148	phosphopyruvate hydratase activity
F0316_RS02075	COG3409	Peptidoglycan-binding domain 1 protein
F0316_RS02075	COG3267	Type II secretory pathway component ExeA
F0316_RS02085	COG4991	sh3 domain protein
F0316_RS02090	COG0306	phosphate transporter
F0316_RS02095	COG1392	Phosphate transport regulator
F0316_RS02100	COG3025	triphosphatase activity
F0316_RS02105	COG0840	transmembrane signaling receptor activity
F0316_RS02110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0316_RS02115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0316_RS02115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0316_RS02120	COG1538	Outer membrane efflux protein
F0316_RS02125	COG0494	nUDIX hydrolase
F0316_RS02130	COG3151	Protein conserved in bacteria
F0316_RS02140	COG3150	esterase
F0316_RS02145	COG0187	DNA topoisomerase II activity
F0316_RS02150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0316_RS02160	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F0316_RS02165	COG0237	dephospho-CoA kinase activity
F0316_RS02175	COG1459	type II secretion system
F0316_RS02180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0316_RS02200	COG0716	FMN binding
F0316_RS02205	COG4974	Belongs to the 'phage' integrase family
F0316_RS02210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0316_RS02215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0316_RS02220	COG0737	Belongs to the 5'-nucleotidase family
F0316_RS02230	COG2186	Transcriptional regulator
F0316_RS02235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0316_RS02240	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0316_RS02245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0316_RS02260	COG3116	cell division
F0316_RS02265	COG0768	penicillin binding
F0316_RS02270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0316_RS02275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0316_RS02285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F0316_RS02290	COG0772	Belongs to the SEDS family
F0316_RS02295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0316_RS02300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0316_RS02305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0316_RS02310	COG0849	cell division
F0316_RS02315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0316_RS02320	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F0316_RS02330	COG0653	protein targeting
F0316_RS02335	COG0494	nUDIX hydrolase
F0316_RS02340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0316_RS02350	COG0505	Belongs to the CarA family
F0316_RS02355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0316_RS02370	COG0730	response to heat
F0316_RS02375	COG0583	DNA-binding transcription factor activity
F0316_RS02380	COG2860	membrane
F0316_RS02385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0316_RS02395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0316_RS02405	COG0493	'glutamate synthase
F0316_RS02410	COG0069	glutamate synthase activity
F0316_RS02410	COG0067	glutamate synthase
F0316_RS02410	COG0070	glutamate synthase
F0316_RS02420	COG0069	glutamate synthase activity
F0316_RS02420	COG0070	glutamate synthase
F0316_RS02420	COG0067	glutamate synthase
F0316_RS02425	COG1242	4 iron, 4 sulfur cluster binding
F0316_RS02430	COG4251	negative regulation of phosphorylation
F0316_RS02430	COG2203	Gaf domain
F0316_RS02430	COG3706	GGDEF domain
F0316_RS02430	COG5001	Diguanylate cyclase
F0316_RS02435	COG0784	Response regulator, receiver
F0316_RS02435	COG2198	Histidine kinase
F0316_RS02435	COG5002	protein histidine kinase activity
F0316_RS02440	COG0745	RESPONSE REGULATOR receiver
F0316_RS02450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0316_RS02470	COG0083	homoserine kinase activity
F0316_RS02475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F0316_RS02480	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
F0316_RS02485	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0316_RS02490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0316_RS02505	COG1115	amino acid carrier protein
F0316_RS02510	COG3022	response to hydroperoxide
F0316_RS02515	COG0084	hydrolase, TatD family'
F0316_RS02520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0316_RS02530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0316_RS02535	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F0316_RS02540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F0316_RS02545	COG0813	purine-nucleoside phosphorylase activity
F0316_RS02555	COG0560	Phosphoserine phosphatase
F0316_RS02565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F0316_RS02570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0316_RS02575	COG1022	Amp-dependent synthetase and ligase
F0316_RS02590	COG3250	beta-galactosidase activity
F0316_RS02595	COG1609	Transcriptional regulator
F0316_RS02600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0316_RS02615	COG0569	domain protein
F0316_RS02615	COG0189	ligase activity
F0316_RS02620	COG0456	acetyltransferase
F0316_RS02630	COG2171	N-acyltransferase activity
F0316_RS02635	COG3141	response to X-ray
F0316_RS02650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F0316_RS02655	COG1074	ATP-dependent DNA helicase activity
F0316_RS02660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0316_RS02670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F0316_RS02670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0316_RS02680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F0316_RS02685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F0316_RS02690	COG2166	iron-sulfur cluster assembly
F0316_RS02695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0316_RS02700	COG0693	protein deglycase activity
F0316_RS02705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0316_RS02710	COG3248	Nucleoside-binding outer membrane protein
F0316_RS02720	COG1595	DNA-templated transcription, initiation
F0316_RS02730	COG2211	Major facilitator Superfamily
F0316_RS02735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0316_RS02745	COG2813	Specifically methylates the guanine in position
F0316_RS02750	COG0271	Belongs to the BolA IbaG family
F0316_RS02755	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0316_RS02760	COG1805	sodium ion transport
F0316_RS02765	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0316_RS02770	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0316_RS02775	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0316_RS02780	COG2871	sodium ion transport
F0316_RS02785	COG1477	protein flavinylation
F0316_RS02805	COG3706	GGDEF domain
F0316_RS02810	COG0733	neurotransmitter:sodium symporter activity
F0316_RS02820	COG0189	ligase activity
F0316_RS02830	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0316_RS02835	COG2252	PERMEase
F0316_RS02840	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F0316_RS02845	COG1073	alpha beta
F0316_RS02855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0316_RS02860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0316_RS02865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0316_RS02870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0316_RS02870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0316_RS02885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0316_RS02890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0316_RS02895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F0316_RS02900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F0316_RS02910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0316_RS02915	COG0024	Methionine aminopeptidase
F0316_RS02920	COG0052	Belongs to the universal ribosomal protein uS2 family
F0316_RS02925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0316_RS02930	COG0528	UMP kinase activity
F0316_RS02935	COG0233	cytoplasmic translational termination
F0316_RS02940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0316_RS02945	COG0575	Belongs to the CDS family
F0316_RS02950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0316_RS02955	COG0750	zinc metalloprotease
F0316_RS02965	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
F0316_RS02970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0316_RS02975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0316_RS02980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0316_RS02985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0316_RS02990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0316_RS02995	COG0587	DNA-directed DNA polymerase activity
F0316_RS03000	COG0825	malonyl-CoA metabolic process
F0316_RS03005	COG0037	tRNA processing
F0316_RS03015	COG3479	Phenolic acid decarboxylase
F0316_RS03020	COG0347	Belongs to the P(II) protein family
F0316_RS03025	COG3021	interspecies interaction between organisms
F0316_RS03030	COG1388	LysM domain
F0316_RS03030	COG0741	lytic transglycosylase activity
F0316_RS03035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0316_RS03040	COG2226	methyltransferase
F0316_RS03045	COG0328	RNA-DNA hybrid ribonuclease activity
F0316_RS03060	COG1960	acyl-CoA dehydrogenase activity
F0316_RS03065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0316_RS03070	COG0121	glutamine amidotransferase
F0316_RS03075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0316_RS03080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0316_RS03085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0316_RS03095	COG1187	pseudouridine synthase activity
F0316_RS03100	COG2840	Smr protein MutS2
F0316_RS03115	COG3735	TraB family
F0316_RS03130	COG2217	Heavy metal translocating P-type atpase
F0316_RS03130	COG2608	mercury ion transmembrane transporter activity
F0316_RS03135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0316_RS03150	COG4774	siderophore transport
F0316_RS03150	COG1629	transport
F0316_RS03155	COG2375	cellular response to nickel ion
F0316_RS03195	COG0784	Response regulator, receiver
F0316_RS03195	COG0835	chemotaxis
F0316_RS03200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0316_RS03205	COG1815	bacterial-type flagellum-dependent cell motility
F0316_RS03220	COG1749	Flagellar hook protein flgE
F0316_RS03225	COG4787	bacterial-type flagellum-dependent cell motility
F0316_RS03235	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F0316_RS03240	COG1706	bacterial-type flagellum-dependent cell motility
F0316_RS03245	COG3951	Flagellar rod assembly protein muramidase FlgJ
F0316_RS03245	COG1705	Flagellar rod assembly protein muramidase FlgJ
F0316_RS03260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0316_RS03265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0316_RS03350	COG0012	GTP binding
F0316_RS03355	COG0193	aminoacyl-tRNA hydrolase activity
F0316_RS03360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0316_RS03370	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F0316_RS03375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0316_RS03380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0316_RS03385	COG2890	protein-(glutamine-N5) methyltransferase activity
F0316_RS03395	COG2912	Transglutaminase-like superfamily
F0316_RS03400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F0316_RS03405	COG0737	Belongs to the 5'-nucleotidase family
F0316_RS03410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0316_RS03415	COG2233	PERMEase
F0316_RS03435	COG1393	Belongs to the ArsC family
F0316_RS03440	COG4783	chaperone-mediated protein folding
F0316_RS03460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F0316_RS03475	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
F0316_RS03495	COG1876	peptidase activity
F0316_RS03505	COG1393	Belongs to the ArsC family
F0316_RS03525	COG2837	iron assimilation
F0316_RS03530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0316_RS03535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0316_RS03540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F0316_RS03545	COG1334	flagellar protein FlaG
F0316_RS03550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F0316_RS03560	COG1516	flagellar protein fliS
F0316_RS03580	COG1677	Flagellar hook-basal body complex protein FliE
F0316_RS03590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F0316_RS03595	COG1317	bacterial-type flagellum organization
F0316_RS03620	COG1580	Controls the rotational direction of flagella during chemotaxis
F0316_RS03645	COG1987	bacterial-type flagellum assembly
F0316_RS03650	COG1684	flagellar biosynthetic protein fliR
F0316_RS03660	COG2840	Smr protein MutS2
F0316_RS03665	COG2890	protein-(glutamine-N5) methyltransferase activity
F0316_RS03675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0316_RS03680	COG2860	membrane
F0316_RS03685	COG3101	peptidyl-lysine hydroxylation
F0316_RS03695	COG0431	NADPH-dependent FMN reductase
F0316_RS03705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0316_RS03710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0316_RS03715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0316_RS03720	COG0735	belongs to the Fur family
F0316_RS03730	COG0583	DNA-binding transcription factor activity
F0316_RS03740	COG1346	cytolysis
F0316_RS03755	COG0596	Alpha beta hydrolase
F0316_RS03760	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
F0316_RS03765	COG0033	Phosphoglucomutase
F0316_RS03775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0316_RS03780	COG0372	Belongs to the citrate synthase family
F0316_RS03785	COG2009	succinate dehydrogenase
F0316_RS03790	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F0316_RS03795	COG1053	succinate dehydrogenase
F0316_RS03805	COG0567	Dehydrogenase, E1 component
F0316_RS03810	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0316_RS03815	COG0045	succinate-CoA ligase (ADP-forming) activity
F0316_RS03825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0316_RS03830	COG1121	(ABC) transporter
F0316_RS03835	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F0316_RS03840	COG4977	sequence-specific DNA binding
F0316_RS03845	COG1918	ferrous iron import across plasma membrane
F0316_RS03865	COG0018	arginyl-trna synthetase
F0316_RS03875	COG1025	Belongs to the peptidase M16 family
F0316_RS03880	COG2062	phosphohistidine phosphatase, SixA
F0316_RS03910	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F0316_RS03915	COG0643	Histidine kinase
F0316_RS03915	COG0784	Response regulator, receiver
F0316_RS03915	COG2198	Histidine kinase
F0316_RS03920	COG2201	protein-glutamate methylesterase activity
F0316_RS03925	COG1192	Involved in chromosome partitioning
F0316_RS03935	COG0835	chemotaxis
F0316_RS03945	COG4133	protoheme IX ABC transporter activity
F0316_RS03950	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0316_RS03955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0316_RS03965	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F0316_RS03970	COG1138	Cytochrome C-type biogenesis protein
F0316_RS03975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0316_RS03990	COG2853	Lipoprotein
F0316_RS04010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F0316_RS04015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0316_RS04020	COG0123	including yeast histone deacetylase and acetoin utilization protein
F0316_RS04035	COG3083	sulfuric ester hydrolase activity
F0316_RS04040	COG3082	Protein of unknown function (DUF1414)
F0316_RS04045	COG3081	Nucleoid-associated protein
F0316_RS04055	COG1757	Na H antiporter
F0316_RS04060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0316_RS04065	COG2095	MarC family integral membrane protein
F0316_RS04070	COG1012	belongs to the aldehyde dehydrogenase family
F0316_RS04070	COG1454	alcohol dehydrogenase
F0316_RS04085	COG0659	secondary active sulfate transmembrane transporter activity
F0316_RS04090	COG1530	ribonuclease E activity
F0316_RS04105	COG0564	pseudouridine synthase activity
F0316_RS04110	COG0424	maF-like protein
F0316_RS04115	COG1399	metal-binding, possibly nucleic acid-binding protein
F0316_RS04120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0316_RS04125	COG0416	fatty acid biosynthetic process
F0316_RS04130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0316_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
F0316_RS04145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0316_RS04150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0316_RS04155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0316_RS04160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0316_RS04165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0316_RS04175	COG0084	hydrolase, TatD family'
F0316_RS04180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0316_RS04180	COG1263	PTS System
F0316_RS04190	COG0733	neurotransmitter:sodium symporter activity
F0316_RS04205	COG4667	esterase of the alpha-beta hydrolase superfamily
F0316_RS04215	COG1940	carbohydrate kinase activity
F0316_RS04220	COG0835	chemotaxis
F0316_RS04220	COG0784	Response regulator, receiver
F0316_RS04235	COG2226	methyltransferase
F0316_RS04245	COG0676	glucose-6-phosphate 1-epimerase activity
F0316_RS04250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0316_RS04255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0316_RS04270	COG3139	Protein of unknown function (DUF1315)
F0316_RS04275	COG0252	asparaginase activity
F0316_RS04280	COG0616	signal peptide processing
F0316_RS04285	COG1902	pentaerythritol trinitrate reductase activity
F0316_RS04285	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0316_RS04290	COG0788	formyltetrahydrofolate deformylase activity
F0316_RS04305	COG1199	ATP-dependent helicase activity
F0316_RS04310	COG1214	PFAM Peptidase M22, glycoprotease
F0316_RS04325	COG0596	Alpha beta hydrolase
F0316_RS04330	COG0318	PFAM AMP-dependent synthetase and ligase
F0316_RS04335	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F0316_RS04350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F0316_RS04355	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F0316_RS04360	COG0436	Aminotransferase
F0316_RS04365	COG1169	isochorismate synthase
F0316_RS04370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F0316_RS04375	COG0596	Alpha beta hydrolase
F0316_RS04395	COG3135	benzoate transporter
F0316_RS04400	COG1396	sequence-specific DNA binding
F0316_RS04405	COG0840	transmembrane signaling receptor activity
F0316_RS04410	COG0477	Major facilitator Superfamily
F0316_RS04430	COG3015	lipoprotein NlpE involved in copper resistance
F0316_RS04435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F0316_RS04440	COG2894	cell division
F0316_RS04445	COG0850	regulation of cytokinetic process
F0316_RS04450	COG3100	YcgL domain-containing protein
F0316_RS04455	COG2951	lytic endotransglycosylase activity
F0316_RS04465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0316_RS04470	COG3469	chitinase activity
F0316_RS04470	COG3325	Belongs to the glycosyl hydrolase 18 family
F0316_RS04475	COG3005	denitrification pathway
F0316_RS04480	COG0243	molybdopterin cofactor binding
F0316_RS04500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0316_RS04510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0316_RS04550	COG4589	Belongs to the CDS family
F0316_RS04560	COG3300	MHYT domain
F0316_RS04560	COG5001	Diguanylate cyclase
F0316_RS04575	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F0316_RS04580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F0316_RS04585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0316_RS04590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F0316_RS04600	COG4191	Histidine kinase
F0316_RS04610	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0316_RS04620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0316_RS04625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0316_RS04630	COG0776	regulation of translation
F0316_RS04635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0316_RS04640	COG1555	photosystem II stabilization
F0316_RS04645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0316_RS04650	COG0539	negative regulation of cytoplasmic translation
F0316_RS04660	COG0776	regulation of translation
F0316_RS04665	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F0316_RS04670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F0316_RS04680	COG0601	transmembrane transport
F0316_RS04685	COG4239	(ABC) transporter, permease
F0316_RS04695	COG0444	Belongs to the ABC transporter superfamily
F0316_RS04700	COG4608	Belongs to the ABC transporter superfamily
F0316_RS04725	COG0583	DNA-binding transcription factor activity
F0316_RS04735	COG0686	Belongs to the AlaDH PNT family
F0316_RS04745	COG1674	ftsk spoiiie
F0316_RS04750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F0316_RS04755	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0316_RS04760	COG2186	Transcriptional regulator
F0316_RS04775	COG0537	adenosine 5'-monophosphoramidase activity
F0316_RS04800	COG3150	esterase
F0316_RS04805	COG1252	NADH dehydrogenase
F0316_RS04825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0316_RS04835	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0316_RS04840	COG1136	(ABC) transporter
F0316_RS04845	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0316_RS04855	COG2333	competence protein COMEC
F0316_RS04855	COG0658	competence protein
F0316_RS04860	COG1132	(ABC) transporter
F0316_RS04865	COG1663	tetraacyldisaccharide 4'-kinase activity
F0316_RS04870	COG2835	tetraacyldisaccharide 4'-kinase activity
F0316_RS04875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F0316_RS04880	COG2719	SpoVR family
F0316_RS04885	COG2718	Belongs to the UPF0229 family
F0316_RS04890	COG2766	serine protein kinase
F0316_RS04895	COG3013	Belongs to the UPF0304 family
F0316_RS04905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0316_RS04915	COG0840	transmembrane signaling receptor activity
F0316_RS04925	COG1882	Formate acetyltransferase
F0316_RS04955	COG4160	amino acid transport
F0316_RS04960	COG0708	Exodeoxyribonuclease III
F0316_RS04965	COG0840	transmembrane signaling receptor activity
F0316_RS04975	COG3923	Primosomal replication protein n
F0316_RS04980	COG0730	response to heat
F0316_RS04985	COG1199	ATP-dependent helicase activity
F0316_RS04990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0316_RS04995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
F0316_RS05000	COG3012	SEC-C Motif Domain Protein
F0316_RS05005	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F0316_RS05010	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0316_RS05015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0316_RS05020	COG0215	cysteine-tRNA ligase activity
F0316_RS05025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0316_RS05030	COG0632	four-way junction helicase activity
F0316_RS05040	COG1271	oxidase subunit
F0316_RS05045	COG1294	oxidase, subunit
F0316_RS05050	COG4890	Cyd operon protein YbgT
F0316_RS05055	COG3790	cyd operon protein YbgE
F0316_RS05060	COG0824	Thioesterase
F0316_RS05065	COG0811	peptide transport
F0316_RS05080	COG0823	Involved in the tonB-independent uptake of proteins
F0316_RS05085	COG2885	chlorophyll binding
F0316_RS05095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0316_RS05105	COG5002	protein histidine kinase activity
F0316_RS05105	COG0784	Response regulator, receiver
F0316_RS05115	COG1012	belongs to the aldehyde dehydrogenase family
F0316_RS05120	COG3284	Transcriptional regulator
F0316_RS05125	COG4628	conserved protein (DUF2132)
F0316_RS05135	COG0415	Belongs to the DNA photolyase family
F0316_RS05185	COG2003	Belongs to the UPF0758 family
F0316_RS05195	COG4409	exo-alpha-(2->6)-sialidase activity
F0316_RS05200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0316_RS05205	COG1940	carbohydrate kinase activity
F0316_RS05220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F0316_RS05225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F0316_RS05230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F0316_RS05235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0316_RS05240	COG1737	Transcriptional regulator
F0316_RS05245	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
F0316_RS05260	COG4932	domain protein
F0316_RS05260	COG5492	domain, Protein
F0316_RS05280	COG2267	carboxylic ester hydrolase activity
F0316_RS05290	COG3064	Membrane
F0316_RS05330	COG2801	Transposase and inactivated derivatives
F0316_RS05420	COG4789	Type iii secretion
F0316_RS05425	COG4792	protein secretion
F0316_RS05455	COG3710	Transcriptional regulator
F0316_RS05470	COG4790	Type iii secretion
F0316_RS05550	COG0582	viral genome integration into host DNA
F0316_RS05565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0316_RS05575	COG3008	intermembrane lipid transfer
F0316_RS05575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0316_RS05580	COG2995	paraquat-inducible protein a
F0316_RS05585	COG1309	transcriptional regulator
F0316_RS05590	COG1012	belongs to the aldehyde dehydrogenase family
F0316_RS05615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0316_RS05620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0316_RS05630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F0316_RS05650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0316_RS05655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0316_RS05660	COG0297	glycogen (starch) synthase activity
F0316_RS05680	COG3070	regulator of competence-specific genes
F0316_RS05685	COG1609	Transcriptional regulator
F0316_RS05700	COG0745	RESPONSE REGULATOR receiver
F0316_RS05705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0316_RS05710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0316_RS05715	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
F0316_RS05720	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F0316_RS05730	COG1979	alcohol dehydrogenase
F0316_RS05735	COG2207	Transcriptional regulator
F0316_RS05750	COG1280	lysine exporter protein (LysE YggA)
F0316_RS05755	COG1032	radical SAM domain protein
F0316_RS05760	COG5001	Diguanylate cyclase
F0316_RS05765	COG0612	Peptidase, M16
F0316_RS05780	COG0583	DNA-binding transcription factor activity
F0316_RS05785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0316_RS05795	COG2350	Protein conserved in bacteria
F0316_RS05800	COG1607	acyl-coa hydrolase
F0316_RS05815	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0316_RS05820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0316_RS05835	COG2116	formate transmembrane transporter activity
F0316_RS05845	COG4459	periplasmic nitrate reductase
F0316_RS05850	COG3005	denitrification pathway
F0316_RS05855	COG0243	molybdopterin cofactor binding
F0316_RS05870	COG1227	inorganic diphosphatase activity
F0316_RS05885	COG4172	Belongs to the ABC transporter superfamily
F0316_RS05900	COG4168	peptide transport system, permease
F0316_RS05905	COG0747	negative chemotaxis
F0316_RS05910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F0316_RS05915	COG1842	Phage shock protein A
F0316_RS05930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0316_RS05945	COG2818	Glycosylase
F0316_RS05950	COG0626	cystathionine gamma-synthase activity
F0316_RS05960	COG0733	neurotransmitter:sodium symporter activity
F0316_RS05965	COG0564	pseudouridine synthase activity
F0316_RS05970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0316_RS05975	COG4136	ATPase activity
F0316_RS05980	COG4135	transport system, permease component
F0316_RS05985	COG4134	Bacterial extracellular solute-binding protein
F0316_RS05995	COG3313	Fe-S protein
F0316_RS06005	COG0842	Transport permease protein
F0316_RS06010	COG1131	(ABC) transporter
F0316_RS06015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0316_RS06020	COG0814	amino acid
F0316_RS06030	COG2239	Acts as a magnesium transporter
F0316_RS06035	COG0784	Response regulator, receiver
F0316_RS06035	COG2205	protein histidine kinase activity
F0316_RS06050	COG4934	collagen metabolic process
F0316_RS06080	COG0840	transmembrane signaling receptor activity
F0316_RS06095	COG3706	GGDEF domain
F0316_RS06095	COG5001	Diguanylate cyclase
F0316_RS06095	COG2203	Gaf domain
F0316_RS06095	COG4251	negative regulation of phosphorylation
F0316_RS06100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0316_RS06120	COG1061	Type III restriction enzyme res subunit
F0316_RS06125	COG1187	pseudouridine synthase activity
F0316_RS06130	COG2814	Major facilitator Superfamily
F0316_RS06140	COG0702	epimerase
F0316_RS06145	COG0534	Mate efflux family protein
F0316_RS06150	COG4181	ATPase activity
F0316_RS06155	COG0577	efflux transmembrane transporter activity
F0316_RS06165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0316_RS06180	COG1748	Saccharopine dehydrogenase
F0316_RS06195	COG1538	Outer membrane efflux protein
F0316_RS06240	COG3385	transposase activity
F0316_RS06255	COG0583	DNA-binding transcription factor activity
F0316_RS06265	COG1451	nucleotide metabolic process
F0316_RS06280	COG3063	Type IV pilus biogenesis stability protein PilW
F0316_RS06285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F0316_RS06305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0316_RS06320	COG3290	protein histidine kinase activity
F0316_RS06325	COG4565	transcriptional regulatory protein
F0316_RS06335	COG0835	chemotaxis
F0316_RS06335	COG0784	Response regulator, receiver
F0316_RS06380	COG1085	galactose-1-phosphate uridylyltransferase
F0316_RS06385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0316_RS06390	COG2017	converts alpha-aldose to the beta-anomer
F0316_RS06400	COG2200	EAL domain
F0316_RS06400	COG2199	diguanylate cyclase activity
F0316_RS06415	COG3527	Alpha-acetolactate decarboxylase
F0316_RS06430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0316_RS06455	COG3097	Belongs to the UPF0267 family
F0316_RS06480	COG1271	oxidase subunit
F0316_RS06485	COG1294	oxidase, subunit
F0316_RS06490	COG1136	(ABC) transporter
F0316_RS06490	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0316_RS06495	COG1136	(ABC) transporter
F0316_RS06495	COG0577	efflux transmembrane transporter activity
F0316_RS06500	COG1136	(ABC) transporter
F0316_RS06500	COG0577	efflux transmembrane transporter activity
F0316_RS06520	COG0583	DNA-binding transcription factor activity
F0316_RS06530	COG2723	6-phospho-beta-galactosidase activity
F0316_RS06535	COG1609	Transcriptional regulator
F0316_RS06540	COG0251	oxidation-reduction process
F0316_RS06545	COG2731	YhcH YjgK YiaL family protein
F0316_RS06550	COG0584	glycerophosphoryl diester phosphodiesterase
F0316_RS06555	COG1349	DNA-binding transcription factor activity
F0316_RS06560	COG3842	ATPase activity
F0316_RS06565	COG0395	ABC-type sugar transport system, permease component
F0316_RS06570	COG1175	transmembrane transport
F0316_RS06585	COG0811	peptide transport
F0316_RS06590	COG0811	peptide transport
F0316_RS06595	COG0848	biopolymer transport protein
F0316_RS06600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0316_RS06610	COG1793	dna ligase
F0316_RS06620	COG0534	Mate efflux family protein
F0316_RS06630	COG3001	Fructosamine kinase
F0316_RS06640	COG0791	NLP P60 protein
F0316_RS06645	COG3290	protein histidine kinase activity
F0316_RS06645	COG0840	transmembrane signaling receptor activity
F0316_RS06655	COG3148	PFAM DTW domain containing protein
F0316_RS06660	COG1940	carbohydrate kinase activity
F0316_RS06675	COG0746	molybdenum cofactor guanylyltransferase activity
F0316_RS06680	COG3842	ATPase activity
F0316_RS06685	COG4662	Binding-protein-dependent transport system inner membrane component
F0316_RS06695	COG2204	response regulator
F0316_RS06700	COG3852	Histidine kinase
F0316_RS06705	COG0488	(ABC) transporter
F0316_RS06710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F0316_RS06740	COG3383	formate dehydrogenase (NAD+) activity
F0316_RS06740	COG0243	molybdopterin cofactor binding
F0316_RS06745	COG0437	4 iron, 4 sulfur cluster binding
F0316_RS06760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0316_RS06765	COG1666	GTP binding
F0316_RS06770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0316_RS06785	COG2996	Protein conserved in bacteria
F0316_RS06795	COG3008	intermembrane lipid transfer
F0316_RS06800	COG2995	paraquat-inducible protein a
F0316_RS06805	COG1132	(ABC) transporter
F0316_RS06810	COG1956	GAF domain-containing protein
F0316_RS06815	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
F0316_RS06830	COG0308	aminopeptidase N
F0316_RS06845	COG0167	dihydroorotate dehydrogenase activity
F0316_RS06855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0316_RS06855	COG0116	Belongs to the methyltransferase superfamily
F0316_RS06865	COG0488	(ABC) transporter
F0316_RS06880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0316_RS06885	COG1067	ATP-dependent peptidase activity
F0316_RS06890	COG3120	sequence-specific DNA binding
F0316_RS06905	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F0316_RS06905	COG3064	Membrane
F0316_RS06905	COG1073	alpha beta
F0316_RS06910	COG2994	toxin metabolic process
F0316_RS06935	COG0784	Response regulator, receiver
F0316_RS06935	COG2205	protein histidine kinase activity
F0316_RS06950	COG3278	Belongs to the heme-copper respiratory oxidase family
F0316_RS06965	COG2010	Cytochrome c
F0316_RS06975	COG2217	Heavy metal translocating P-type atpase
F0316_RS06990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0316_RS06995	COG0589	response to stress
F0316_RS07000	COG0037	tRNA processing
F0316_RS07020	COG3842	ATPase activity
F0316_RS07030	COG1177	transmembrane transport
F0316_RS07040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0316_RS07055	COG1115	amino acid carrier protein
F0316_RS07060	COG1280	lysine exporter protein (LysE YggA)
F0316_RS07080	COG3501	Rhs element vgr protein
F0316_RS07090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F0316_RS07100	COG2814	Major facilitator Superfamily
F0316_RS07105	COG1566	PFAM secretion protein HlyD family protein
F0316_RS07110	COG1538	Outer membrane efflux protein
F0316_RS07120	COG0513	Belongs to the DEAD box helicase family
F0316_RS07130	COG0840	transmembrane signaling receptor activity
F0316_RS07135	COG3290	protein histidine kinase activity
F0316_RS07135	COG0840	transmembrane signaling receptor activity
F0316_RS07140	COG0835	chemotaxis
F0316_RS07145	COG2201	protein-glutamate methylesterase activity
F0316_RS07155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0316_RS07160	COG0643	Histidine kinase
F0316_RS07160	COG0784	Response regulator, receiver
F0316_RS07160	COG2198	Histidine kinase
F0316_RS07165	COG2198	Histidine kinase
F0316_RS07165	COG0643	Histidine kinase
F0316_RS07175	COG0745	RESPONSE REGULATOR receiver
F0316_RS07190	COG0415	Belongs to the DNA photolyase family
F0316_RS07195	COG0477	Major facilitator Superfamily
F0316_RS07200	COG0583	DNA-binding transcription factor activity
F0316_RS07210	COG0095	Lipoate-protein ligase
F0316_RS07215	COG0443	Heat shock 70 kDa protein
F0316_RS07225	COG1643	Atp-dependent helicase
F0316_RS07265	COG0443	Heat shock 70 kDa protein
F0316_RS07270	COG0443	Heat shock 70 kDa protein
F0316_RS07275	COG3706	GGDEF domain
F0316_RS07305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F0316_RS07310	COG0602	queuosine metabolic process
F0316_RS07315	COG0561	phosphatase activity
F0316_RS07325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0316_RS07330	COG4597	amino acid ABC transporter
F0316_RS07335	COG0765	amino acid transport
F0316_RS07340	COG1126	abc transporter atp-binding protein
F0316_RS07345	COG0670	Belongs to the BI1 family
F0316_RS07350	COG2920	part of a sulfur-relay system
F0316_RS07355	COG1254	Belongs to the acylphosphatase family
F0316_RS07360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0316_RS07365	COG3706	GGDEF domain
F0316_RS07380	COG4999	Histidine kinase
F0316_RS07380	COG3437	response regulator, receiver
F0316_RS07380	COG3850	Histidine kinase
F0316_RS07380	COG2205	protein histidine kinase activity
F0316_RS07385	COG3437	response regulator, receiver
F0316_RS07390	COG0625	glutathione transferase activity
F0316_RS07400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F0316_RS07410	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0316_RS07440	COG0372	Belongs to the citrate synthase family
F0316_RS07445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F0316_RS07485	COG1566	PFAM secretion protein HlyD family protein
F0316_RS07505	COG1129	ABC transporter
F0316_RS07535	COG0745	RESPONSE REGULATOR receiver
F0316_RS07540	COG2205	protein histidine kinase activity
F0316_RS07545	COG3713	MltA-interacting MipA family protein
F0316_RS07550	COG2990	Protein conserved in bacteria
F0316_RS07560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0316_RS07560	COG4191	Histidine kinase
F0316_RS07565	COG0471	metal ion transport
F0316_RS07575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0316_RS07595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0316_RS07605	COG3768	UPF0283 membrane protein
F0316_RS07610	COG3106	COG3106 Predicted ATPase
F0316_RS07625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0316_RS07630	COG0494	nUDIX hydrolase
F0316_RS07635	COG0814	amino acid
F0316_RS07640	COG1760	l-serine dehydratase
F0316_RS07645	COG0720	synthase
F0316_RS07655	COG0017	Asparaginyl-tRNA synthetase
F0316_RS07660	COG0351	phosphomethylpyrimidine kinase
F0316_RS07665	COG2770	Histidine kinase
F0316_RS07665	COG3437	response regulator, receiver
F0316_RS07670	COG1448	Aminotransferase
F0316_RS07685	COG0840	transmembrane signaling receptor activity
F0316_RS07690	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F0316_RS07695	COG2943	transferase activity, transferring hexosyl groups
F0316_RS07700	COG1609	Transcriptional regulator
F0316_RS07705	COG3394	polysaccharide catabolic process
F0316_RS07710	COG1486	melibiose metabolic process
F0316_RS07715	COG1447	Phosphotransferase system cellobiose-specific component IIA
F0316_RS07725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0316_RS07730	COG0726	polysaccharide deacetylase
F0316_RS07735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0316_RS07740	COG1846	Transcriptional regulator
F0316_RS07770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F0316_RS07785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0316_RS07790	COG3108	Peptidase M15
F0316_RS07820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0316_RS07830	COG2814	Major facilitator Superfamily
F0316_RS07840	COG1054	Belongs to the UPF0176 family
F0316_RS07850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0316_RS07855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0316_RS07860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0316_RS07910	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
F0316_RS07915	COG4139	cobalamin transport
F0316_RS07920	COG2988	succinylglutamate desuccinylase activity
F0316_RS07935	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F0316_RS07940	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0316_RS07945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0316_RS07950	COG1823	symporter activity
F0316_RS07955	COG2925	Exonuclease
F0316_RS07960	COG1380	Effector of murein hydrolase LrgA
F0316_RS07965	COG1346	cytolysis
F0316_RS08005	COG0776	regulation of translation
F0316_RS08010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0316_RS08010	COG0072	phenylalanine-tRNA ligase activity
F0316_RS08015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0316_RS08055	COG0322	excinuclease ABC activity
F0316_RS08060	COG2197	response regulator
F0316_RS08065	COG0417	DNA replication proofreading
F0316_RS08070	COG5001	Diguanylate cyclase
F0316_RS08080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0316_RS08085	COG3099	Belongs to the UPF0263 family
F0316_RS08100	COG1228	amidohydrolase
F0316_RS08105	COG0010	Belongs to the arginase family
F0316_RS08110	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0316_RS08115	COG2986	histidine ammonia-lyase
F0316_RS08135	COG0277	FAD linked oxidase domain protein
F0316_RS08135	COG0247	lactate metabolic process
F0316_RS08150	COG2885	chlorophyll binding
F0316_RS08170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0316_RS08180	COG0281	malic enzyme
F0316_RS08190	COG2949	membrane
F0316_RS08195	COG3706	GGDEF domain
F0316_RS08200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0316_RS08210	COG0492	ferredoxin-NADP+ reductase activity
F0316_RS08215	COG4988	ABC transporter
F0316_RS08220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F0316_RS08225	COG1187	pseudouridine synthase activity
F0316_RS08230	COG0009	L-threonylcarbamoyladenylate synthase
F0316_RS08235	COG0613	PHP domain protein
F0316_RS08245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0316_RS08250	COG0512	Glutamine amidotransferase of anthranilate synthase
F0316_RS08255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0316_RS08260	COG0134	indole-3-glycerol-phosphate synthase activity
F0316_RS08260	COG0135	phosphoribosylanthranilate isomerase activity
F0316_RS08265	COG0133	tryptophan synthase activity
F0316_RS08270	COG0159	tryptophan synthase activity
F0316_RS08280	COG1435	thymidine kinase activity
F0316_RS08285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0316_RS08290	COG1801	Protein of unknown function DUF72
F0316_RS08295	COG4106	trans-aconitate 2-methyltransferase activity
F0316_RS08300	COG0500	methyltransferase
F0316_RS08305	COG4067	protein conserved in archaea
F0316_RS08305	COG0189	ligase activity
F0316_RS08320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0316_RS08330	COG3852	Histidine kinase
F0316_RS08345	COG3070	regulator of competence-specific genes
F0316_RS08355	COG2431	L-lysine efflux transmembrane transporter activity
F0316_RS08365	COG0076	glutamate decarboxylase activity
F0316_RS08370	COG1737	Transcriptional regulator
F0316_RS08375	COG1454	alcohol dehydrogenase
F0316_RS08375	COG1012	belongs to the aldehyde dehydrogenase family
F0316_RS08380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0316_RS08385	COG2985	domain, Protein
F0316_RS08385	COG3273	potassium ion transport
F0316_RS08390	COG0542	response to heat
F0316_RS08395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0316_RS08400	COG1278	Cold shock
F0316_RS08410	COG1187	pseudouridine synthase activity
F0316_RS08415	COG0140	phosphoribosyl-ATP diphosphatase activity
F0316_RS08415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0316_RS08420	COG0107	imidazoleglycerol-phosphate synthase activity
F0316_RS08425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0316_RS08430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0316_RS08435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0316_RS08435	COG0131	Imidazoleglycerol-phosphate dehydratase
F0316_RS08440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0316_RS08445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0316_RS08450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0316_RS08455	COG1757	Na H antiporter
F0316_RS08460	COG2916	Histone family protein nucleoid-structuring protein H-NS
F0316_RS08465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0316_RS08470	COG0482	sulfurtransferase activity
F0316_RS08475	COG2915	High frequency lysogenization protein hflD homolog
F0316_RS08480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0316_RS08490	COG2268	Band 7 protein
F0316_RS08500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0316_RS08515	COG0300	oxidoreductase activity
F0316_RS08525	COG0501	Belongs to the peptidase M48B family
F0316_RS08535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0316_RS08540	COG2226	methyltransferase
F0316_RS08545	COG0156	8-amino-7-oxononanoate synthase activity
F0316_RS08550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0316_RS08555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F0316_RS08560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0316_RS08565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0316_RS08570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F0316_RS08575	COG0653	protein targeting
F0316_RS08580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0316_RS08585	COG2203	Gaf domain
F0316_RS08585	COG2199	diguanylate cyclase activity
F0316_RS08595	COG4120	Belongs to the binding-protein-dependent transport system permease family
F0316_RS08605	COG4628	conserved protein (DUF2132)
F0316_RS08610	COG3092	negative regulation of chromosome organization
F0316_RS08615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0316_RS08620	COG0280	phosphate acetyltransferase
F0316_RS08620	COG0857	belongs to the CobB CobQ family
F0316_RS08625	COG0435	Glutathione S-transferase
F0316_RS08630	COG4608	Belongs to the ABC transporter superfamily
F0316_RS08635	COG0444	Belongs to the ABC transporter superfamily
F0316_RS08640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0316_RS08645	COG0601	transmembrane transport
F0316_RS08665	COG2204	response regulator
F0316_RS08670	COG5001	Diguanylate cyclase
F0316_RS08670	COG3300	MHYT domain
F0316_RS08675	COG4191	Histidine kinase
F0316_RS08680	COG5002	protein histidine kinase activity
F0316_RS08690	COG2201	protein-glutamate methylesterase activity
F0316_RS08705	COG0009	L-threonylcarbamoyladenylate synthase
F0316_RS08725	COG1881	PFAM PEBP family protein
F0316_RS08750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0316_RS08755	COG0640	Transcriptional regulator
F0316_RS08765	COG3706	GGDEF domain
F0316_RS08785	COG1946	Acyl-CoA thioesterase
F0316_RS08790	COG1522	sequence-specific DNA binding
F0316_RS08800	COG0616	signal peptide processing
F0316_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
F0316_RS08815	COG2983	Belongs to the UPF0260 family
F0316_RS08825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0316_RS08830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0316_RS08835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0316_RS08840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0316_RS08845	COG2832	Protein of unknown function (DUF454)
F0316_RS08855	COG0745	RESPONSE REGULATOR receiver
F0316_RS08860	COG0583	DNA-binding transcription factor activity
F0316_RS08865	COG0778	Nitroreductase
F0316_RS08870	COG1024	Enoyl-CoA hydratase
F0316_RS08870	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0316_RS08875	COG0183	Belongs to the thiolase family
F0316_RS08895	COG2067	long-chain fatty acid transport protein
F0316_RS08905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0316_RS08910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F0316_RS08915	COG2982	Protein involved in outer membrane biogenesis
F0316_RS08920	COG0572	uridine kinase
F0316_RS08930	COG0489	protein tyrosine kinase activity
F0316_RS08935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0316_RS08935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0316_RS08945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F0316_RS08960	COG0517	IMP dehydrogenase activity
F0316_RS08960	COG0617	tRNA 3'-terminal CCA addition
F0316_RS08960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F0316_RS08965	COG2199	diguanylate cyclase activity
F0316_RS08970	COG0314	molybdopterin synthase activity
F0316_RS08975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F0316_RS08980	COG0315	cyclic pyranopterin monophosphate synthase activity
F0316_RS08985	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0316_RS08990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0316_RS08995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0316_RS09000	COG2198	Histidine kinase
F0316_RS09005	COG2204	response regulator
F0316_RS09015	COG0556	nucleotide-excision repair
F0316_RS09025	COG4657	Part of a membrane complex involved in electron transport
F0316_RS09030	COG2878	Part of a membrane complex involved in electron transport
F0316_RS09035	COG4656	Part of a membrane complex involved in electron transport
F0316_RS09050	COG4660	Part of a membrane complex involved in electron transport
F0316_RS09055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F0316_RS09060	COG0346	lactoylglutathione lyase activity
F0316_RS09075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0316_RS09080	COG2056	Na+-H+ antiporter family
F0316_RS09085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F0316_RS09090	COG1286	toxin biosynthetic process
F0316_RS09095	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
F0316_RS09100	COG0285	dihydrofolate synthase activity
F0316_RS09105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0316_RS09110	COG0101	tRNA pseudouridine synthase activity
F0316_RS09125	COG2190	(PTS) system
F0316_RS09125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0316_RS09125	COG1263	PTS System
F0316_RS09130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0316_RS09135	COG1940	carbohydrate kinase activity
F0316_RS09135	COG1846	Transcriptional regulator
F0316_RS09140	COG4651	solute:proton antiporter activity
F0316_RS09140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0316_RS09145	COG0367	asparagine synthase
F0316_RS09155	COG3104	oligopeptide transport
F0316_RS09160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0316_RS09165	COG0563	adenylate kinase activity
F0316_RS09170	COG0326	Molecular chaperone. Has ATPase activity
F0316_RS09175	COG3710	Transcriptional regulator
F0316_RS09190	COG0622	Phosphoesterase
F0316_RS09195	COG1090	epimerase
F0316_RS09200	COG0300	oxidoreductase activity
F0316_RS09210	COG3118	belongs to the thioredoxin family
F0316_RS09215	COG0330	HflC and HflK could
F0316_RS09220	COG1585	Membrane protein implicated in regulation of membrane protease activity
F0316_RS09225	COG0789	Transcriptional regulator
F0316_RS09240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0316_RS09245	COG3115	cell septum assembly
F0316_RS09250	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
F0316_RS09255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0316_RS09265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0316_RS09275	COG2190	(PTS) system
F0316_RS09280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0316_RS09285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0316_RS09290	COG1702	phosphate starvation-inducible protein PhoH
F0316_RS09295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0316_RS09300	COG4535	Mg2 and Co2 transporter CorC
F0316_RS09305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F0316_RS09310	COG2888	peptidyl-tyrosine sulfation
F0316_RS09315	COG0495	leucyl-tRNA aminoacylation
F0316_RS09320	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F0316_RS09325	COG1466	dna polymerase III delta subunit
F0316_RS09330	COG0799	negative regulation of ribosome biogenesis
F0316_RS09335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F0316_RS09340	COG0768	penicillin binding
F0316_RS09345	COG0772	Belongs to the SEDS family
F0316_RS09350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0316_RS09355	COG1686	Belongs to the peptidase S11 family
F0316_RS09360	COG2921	Belongs to the UPF0250 family
F0316_RS09365	COG0321	lipoyl(octanoyl) transferase activity
F0316_RS09370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0316_RS09380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0316_RS09405	COG1596	polysaccharide export
F0316_RS09415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0316_RS09445	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F0316_RS09455	COG0438	transferase activity, transferring glycosyl groups
F0316_RS09465	COG0297	glycogen (starch) synthase activity
F0316_RS09485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0316_RS09490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0316_RS09495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0316_RS09500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0316_RS09525	COG0366	Alpha amylase catalytic
F0316_RS09530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0316_RS09530	COG1263	PTS System
F0316_RS09535	COG1609	Transcriptional regulator
F0316_RS09540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0316_RS09545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0316_RS09550	COG2011	ABC-type metal ion transport system permease component
F0316_RS09555	COG1464	Belongs to the NlpA lipoprotein family
F0316_RS09560	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
F0316_RS09570	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0316_RS09570	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0316_RS09585	COG1611	Belongs to the LOG family
F0316_RS09590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0316_RS09595	COG2363	Small membrane protein
F0316_RS09600	COG0583	DNA-binding transcription factor activity
F0316_RS09610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0316_RS09610	COG0301	tRNA thio-modification
F0316_RS09620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F0316_RS09625	COG1722	exodeoxyribonuclease VII activity
F0316_RS09630	COG0142	geranyltranstransferase activity
F0316_RS09635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0316_RS09640	COG0564	pseudouridine synthase activity
F0316_RS09645	COG3098	single-species biofilm formation
F0316_RS09660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0316_RS09670	COG1671	Belongs to the UPF0178 family
F0316_RS09675	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0316_RS09680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0316_RS09685	COG0254	rRNA binding
F0316_RS09690	COG1720	tRNA m6t6A37 methyltransferase activity
F0316_RS09695	COG0442	prolyl-tRNA aminoacylation
F0316_RS09715	COG0047	phosphoribosylformylglycinamidine synthase activity
F0316_RS09715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0316_RS09725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F0316_RS09735	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0316_RS09770	COG0484	heat shock protein binding
F0316_RS09775	COG0443	Heat shock 70 kDa protein
F0316_RS09780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0316_RS09785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0316_RS09790	COG0497	DNA recombination
F0316_RS09795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0316_RS09800	COG2914	Belongs to the UPF0125 (RnfH) family
F0316_RS09805	COG2867	negative regulation of translational initiation
F0316_RS09810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0316_RS09870	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F0316_RS09880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F0316_RS09885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0316_RS09905	COG3051	citrate lyase alpha subunit
F0316_RS09910	COG2301	Belongs to the HpcH HpaI aldolase family
F0316_RS09920	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F0316_RS09930	COG3630	sodium ion export across plasma membrane
F0316_RS09935	COG0511	ligase activity, forming carbon-carbon bonds
F0316_RS09935	COG5016	pyruvate
F0316_RS09940	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0316_RS09950	COG4565	transcriptional regulatory protein
F0316_RS09965	COG0583	DNA-binding transcription factor activity
F0316_RS09975	COG1115	amino acid carrier protein
F0316_RS09980	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F0316_RS09985	COG0583	DNA-binding transcription factor activity
F0316_RS09995	COG1120	ATPase activity
F0316_RS10000	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0316_RS10005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0316_RS10010	COG4592	Periplasmic binding protein
F0316_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
F0316_RS10025	COG1169	isochorismate synthase
F0316_RS10030	COG1021	2,3-dihydroxybenzoate-AMP ligase
F0316_RS10035	COG3433	isochorismatase activity
F0316_RS10035	COG1535	isochorismatase
F0316_RS10040	COG1584	GPR1 FUN34 yaaH family protein
F0316_RS10050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0316_RS10050	COG0519	Catalyzes the synthesis of GMP from XMP
F0316_RS10055	COG0517	IMP dehydrogenase activity
F0316_RS10055	COG0516	GMP reductase activity
F0316_RS10060	COG1570	exodeoxyribonuclease VII activity
F0316_RS10075	COG1160	GTP binding
F0316_RS10080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0316_RS10085	COG2976	Protein conserved in bacteria
F0316_RS10090	COG0124	histidyl-tRNA synthetase
F0316_RS10095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0316_RS10100	COG1426	Protein conserved in bacteria
F0316_RS10110	COG0105	UTP biosynthetic process
F0316_RS10115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0316_RS10120	COG2975	iron-sulfur cluster assembly
F0316_RS10125	COG0633	Ferredoxin
F0316_RS10145	COG0822	iron-sulfur transferase activity
F0316_RS10155	COG1959	2 iron, 2 sulfur cluster binding
F0316_RS10165	COG0483	inositol monophosphate 1-phosphatase activity
F0316_RS10170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0316_RS10175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0316_RS10180	COG1862	Preprotein translocase
F0316_RS10195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0316_RS10200	COG0517	IMP dehydrogenase activity
F0316_RS10210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0316_RS10215	COG0583	DNA-binding transcription factor activity
F0316_RS10220	COG0450	alkyl hydroperoxide reductase
F0316_RS10225	COG3142	Participates in the control of copper homeostasis
F0316_RS10240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0316_RS10245	COG0581	inorganic phosphate transmembrane transporter activity
F0316_RS10255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0316_RS10260	COG0248	Ppx GppA phosphatase
F0316_RS10270	COG5002	protein histidine kinase activity
F0316_RS10275	COG0745	RESPONSE REGULATOR receiver
F0316_RS10285	COG0826	peptidase U32
F0316_RS10290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0316_RS10335	COG0542	response to heat
F0316_RS10345	COG0564	pseudouridine synthase activity
F0316_RS10350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0316_RS10355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0316_RS10360	COG1605	Chorismate mutase
F0316_RS10360	COG0077	Prephenate dehydratase
F0316_RS10365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0316_RS10370	COG5001	Diguanylate cyclase
F0316_RS10380	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
F0316_RS10390	COG0488	(ABC) transporter
F0316_RS10400	COG0287	Prephenate dehydrogenase
F0316_RS10400	COG1605	Chorismate mutase
F0316_RS10405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0316_RS10410	COG3275	phosphorelay sensor kinase activity
F0316_RS10415	COG3279	Response regulator of the LytR AlgR family
F0316_RS10425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F0316_RS10430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0316_RS10445	COG1966	Carbon starvation protein
F0316_RS10450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0316_RS10455	COG1047	Peptidyl-prolyl cis-trans
F0316_RS10460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0316_RS10470	COG0196	riboflavin kinase activity
F0316_RS10475	COG0728	peptidoglycan biosynthetic process
F0316_RS10480	COG0268	Binds directly to 16S ribosomal RNA
F0316_RS10485	COG0640	Transcriptional regulator
F0316_RS10490	COG0583	DNA-binding transcription factor activity
F0316_RS10495	COG1283	sodium-dependent phosphate transmembrane transporter activity
F0316_RS10500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0316_RS10505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0316_RS10510	COG0730	response to heat
F0316_RS10515	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
F0316_RS10520	COG0494	nUDIX hydrolase
F0316_RS10530	COG0667	Aldo Keto reductase
F0316_RS10540	COG2204	response regulator
F0316_RS10545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0316_RS10565	COG0513	Belongs to the DEAD box helicase family
F0316_RS10590	COG3153	acetyltransferase
F0316_RS10595	COG3154	lipid carrier protein
F0316_RS10605	COG0826	peptidase U32
F0316_RS10610	COG0826	peptidase U32
F0316_RS10635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0316_RS10645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0316_RS10650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0316_RS10655	COG0195	Participates in both transcription termination and antitermination
F0316_RS10660	COG0779	Required for maturation of 30S ribosomal subunits
F0316_RS10675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0316_RS10690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0316_RS10695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0316_RS10700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F0316_RS10705	COG1534	Rna-binding protein
F0316_RS10710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0316_RS10715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0316_RS10720	COG2027	D-alanyl-D-alanine carboxypeptidase
F0316_RS10725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0316_RS10730	COG0739	heme binding
F0316_RS10735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0316_RS10745	COG0316	Belongs to the HesB IscA family
F0316_RS10750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0316_RS10760	COG0628	permease
F0316_RS10765	COG2813	Specifically methylates the guanine in position
F0316_RS10770	COG2205	protein histidine kinase activity
F0316_RS10770	COG0784	Response regulator, receiver
F0316_RS10780	COG0747	negative chemotaxis
F0316_RS10785	COG0601	transmembrane transport
F0316_RS10790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0316_RS10795	COG0444	Belongs to the ABC transporter superfamily
F0316_RS10800	COG4608	Belongs to the ABC transporter superfamily
F0316_RS10810	COG2971	BadF BadG BcrA BcrD
F0316_RS10830	COG3842	ATPase activity
F0316_RS10840	COG1840	ABC-type Fe3 transport system, periplasmic component
F0316_RS10845	COG0004	ammonium transporteR
F0316_RS10850	COG0347	Belongs to the P(II) protein family
F0316_RS10855	COG3112	Uncharacterised protein family (UPF0231)
F0316_RS10860	COG1049	propionate catabolic process, 2-methylcitrate cycle
F0316_RS10865	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0316_RS10870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0316_RS10875	COG1643	Atp-dependent helicase
F0316_RS10885	COG1489	DNA binding
F0316_RS10895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0316_RS10905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0316_RS10910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0316_RS10915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0316_RS10920	COG0842	Transport permease protein
F0316_RS10925	COG1131	(ABC) transporter
F0316_RS10930	COG0659	secondary active sulfate transmembrane transporter activity
F0316_RS10935	COG0288	reversible hydration of carbon dioxide
F0316_RS10955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F0316_RS10960	COG3107	peptidoglycan biosynthetic process
F0316_RS10965	COG0792	nuclease activity
F0316_RS10970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0316_RS10975	COG2823	Periplasmic or secreted lipoprotein
F0316_RS10980	COG2969	positive regulation of protein catabolic process
F0316_RS10985	COG0625	glutathione transferase activity
F0316_RS10990	COG2857	Cytochrome c1
F0316_RS10995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F0316_RS11000	COG0723	plastoquinol--plastocyanin reductase activity
F0316_RS11005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0316_RS11010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0316_RS11015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F0316_RS11025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0316_RS11030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0316_RS11035	COG0335	large ribosomal subunit rRNA binding
F0316_RS11040	COG0336	Belongs to the RNA methyltransferase TrmD family
F0316_RS11045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0316_RS11050	COG0228	four-way junction DNA binding
F0316_RS11055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0316_RS11060	COG4137	Cytochrome C assembly protein
F0316_RS11065	COG4536	flavin adenine dinucleotide binding
F0316_RS11070	COG1854	S-ribosylhomocysteine lyase activity
F0316_RS11075	COG2918	glutathione biosynthetic process
F0316_RS11080	COG0612	Peptidase, M16
F0316_RS11085	COG1238	metal cluster binding
F0316_RS11095	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F0316_RS11100	COG5016	pyruvate
F0316_RS11100	COG0511	ligase activity, forming carbon-carbon bonds
F0316_RS11105	COG3630	sodium ion export across plasma membrane
F0316_RS11150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F0316_RS11155	COG0527	aspartate kinase activity
F0316_RS11160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0316_RS11165	COG2137	regulation of response to DNA damage stimulus
F0316_RS11170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0316_RS11180	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F0316_RS11185	COG4208	sulfate ABC transporter
F0316_RS11205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F0316_RS11210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0316_RS11220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0316_RS11225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F0316_RS11230	COG0585	pseudouridine synthase activity
F0316_RS11235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0316_RS11240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0316_RS11245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F0316_RS11250	COG1968	undecaprenyl-diphosphatase activity
F0316_RS11255	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0316_RS11260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0316_RS11270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F0316_RS11280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0316_RS11285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F0316_RS11290	COG1610	YqeY-like protein
F0316_RS11390	COG2378	regulation of single-species biofilm formation
F0316_RS11410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F0316_RS11415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0316_RS11420	COG1349	DNA-binding transcription factor activity
F0316_RS11440	COG1279	arginine transmembrane transporter activity
F0316_RS11445	COG0668	transmembrane transport
F0316_RS11455	COG0191	fructose-bisphosphate aldolase activity
F0316_RS11460	COG0126	phosphoglycerate kinase activity
F0316_RS11465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0316_RS11470	COG4771	TonB-dependent receptor
F0316_RS11475	COG0583	DNA-binding transcription factor activity
F0316_RS11480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0316_RS11485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0316_RS11495	COG2356	endonuclease I
F0316_RS11500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F0316_RS11505	COG0189	ligase activity
F0316_RS11510	COG1678	Uncharacterized ACR, COG1678
F0316_RS11515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0316_RS11520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0316_RS11540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0316_RS11545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0316_RS11550	COG0762	integral membrane protein
F0316_RS11555	COG1872	DUF167
F0316_RS11565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F0316_RS11570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0316_RS11575	COG2066	Belongs to the glutaminase family
F0316_RS11580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0316_RS11585	COG1194	a g-specific adenine glycosylase
F0316_RS11590	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F0316_RS11595	COG0741	lytic transglycosylase activity
F0316_RS11650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0316_RS11655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0316_RS11660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0316_RS11665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0316_RS11670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0316_RS11675	COG2967	ApaG domain
F0316_RS11680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0316_RS11690	COG3610	response to peptide
F0316_RS11695	COG2966	Psort location CytoplasmicMembrane, score
F0316_RS11700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0316_RS11705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0316_RS11710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0316_RS11715	COG0142	geranyltranstransferase activity
F0316_RS11720	COG0531	amino acid
F0316_RS11725	COG0039	L-malate dehydrogenase activity
F0316_RS11730	COG1438	arginine binding
F0316_RS11740	COG2358	TRAP transporter, solute receptor (TAXI family
F0316_RS11750	COG0589	response to stress
F0316_RS11775	COG2235	arginine
F0316_RS11785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0316_RS11790	COG3164	Protein of unknown function
F0316_RS11800	COG0424	maF-like protein
F0316_RS11805	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F0316_RS11810	COG1792	Involved in formation and maintenance of cell shape
F0316_RS11815	COG1077	Cell shape determining protein MreB Mrl
F0316_RS11850	COG2165	general secretion pathway protein
F0316_RS11860	COG1459	type II secretion system
F0316_RS11865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0316_RS11875	COG3267	Type II secretory pathway component ExeA
F0316_RS11875	COG3409	Peptidoglycan-binding domain 1 protein
F0316_RS11900	COG2199	diguanylate cyclase activity
F0316_RS11900	COG2200	EAL domain
F0316_RS11905	COG0629	single-stranded DNA binding
F0316_RS11920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0316_RS11930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0316_RS11935	COG0527	aspartate kinase activity
F0316_RS11940	COG1410	methionine synthase
F0316_RS11940	COG0646	methionine synthase
F0316_RS11975	COG0175	sulfate reduction
F0316_RS11985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0316_RS12010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0316_RS12015	COG0735	belongs to the Fur family
F0316_RS12030	COG0166	Belongs to the GPI family
F0316_RS12055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F0316_RS12070	COG0556	nucleotide-excision repair
F0316_RS12115	COG0432	Pfam Uncharacterised protein family UPF0047
F0316_RS12125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0316_RS12140	COG0359	binds to the 23S rRNA
F0316_RS12145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0316_RS12150	COG2965	DNA replication, synthesis of RNA primer
F0316_RS12155	COG0360	Binds together with S18 to 16S ribosomal RNA
F0316_RS12165	COG2906	2 iron, 2 sulfur cluster binding
F0316_RS12170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0316_RS12175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0316_RS12180	COG0049	tRNA binding
F0316_RS12195	COG2923	Belongs to the DsrF TusC family
F0316_RS12200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F0316_RS12205	COG2964	Protein conserved in bacteria
F0316_RS12210	COG0545	Peptidyl-prolyl cis-trans isomerase
F0316_RS12220	COG2900	Belongs to the SlyX family
F0316_RS12225	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
F0316_RS12230	COG0330	HflC and HflK could
F0316_RS12235	COG0330	HflC and HflK could
F0316_RS12240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0316_RS12245	COG1923	regulation of RNA biosynthetic process
F0316_RS12250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0316_RS12270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0316_RS12315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F0316_RS12320	COG1162	GTPase activity
F0316_RS12325	COG0688	phosphatidylethanolamine metabolic process
F0316_RS12330	COG0471	metal ion transport
F0316_RS12340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F0316_RS12355	COG4942	peptidase
F0316_RS12370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0316_RS12375	COG2816	NAD+ diphosphatase activity
F0316_RS12380	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
F0316_RS12385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0316_RS12390	COG0085	RNA polymerase activity
F0316_RS12395	COG0222	ribosome binding
F0316_RS12400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0316_RS12410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F0316_RS12415	COG0250	Participates in transcription elongation, termination and antitermination
F0316_RS12420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0316_RS12425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0316_RS12450	COG1072	(Pantothenic acid kinase))
F0316_RS12460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0316_RS12470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0316_RS12545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F0316_RS12560	COG3118	belongs to the thioredoxin family
F0316_RS12565	COG0513	Belongs to the DEAD box helicase family
F0316_RS12570	COG0248	Ppx GppA phosphatase
F0316_RS12575	COG2205	protein histidine kinase activity
F0316_RS12575	COG0784	Response regulator, receiver
F0316_RS12580	COG2814	Major facilitator Superfamily
F0316_RS12600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0316_RS12605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0316_RS12610	COG0511	ligase activity, forming carbon-carbon bonds
F0316_RS12615	COG0439	Biotin carboxylase
F0316_RS12620	COG2264	protein methyltransferase activity
F0316_RS12625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0316_RS12630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F0316_RS12635	COG1609	Transcriptional regulator
F0316_RS12645	COG0387	Pfam Sodium calcium exchanger
F0316_RS12650	COG0129	dihydroxy-acid dehydratase activity
F0316_RS12655	COG3265	gluconokinase activity
F0316_RS12665	COG0800	Aldolase
F0316_RS12685	COG0840	transmembrane signaling receptor activity
F0316_RS12690	COG1982	Orn Lys Arg decarboxylase major
F0316_RS12695	COG0531	amino acid
F0316_RS12700	COG3710	Transcriptional regulator
F0316_RS12705	COG0789	Transcriptional regulator
F0316_RS12720	COG0151	Belongs to the GarS family
F0316_RS12730	COG0776	regulation of translation
F0316_RS12735	COG1253	flavin adenine dinucleotide binding
F0316_RS12745	COG3068	Protein conserved in bacteria
F0316_RS12755	COG1573	uracil-dna glycosylase
F0316_RS12760	COG0668	transmembrane transport
F0316_RS12775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F0316_RS12785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0316_RS12850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0316_RS12865	COG1596	polysaccharide export
F0316_RS12885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0316_RS12895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0316_RS12970	COG1216	Glycosyl transferase, family 2
F0316_RS12970	COG0438	transferase activity, transferring glycosyl groups
F0316_RS12980	COG1682	transport, permease protein
F0316_RS13005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0316_RS13025	COG0859	PFAM glycosyl transferase family 9
F0316_RS13035	COG1519	Transferase
F0316_RS13040	COG0456	acetyltransferase
F0316_RS13045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0316_RS13060	COG3642	lipopolysaccharide core region biosynthetic process
F0316_RS13065	COG0859	PFAM glycosyl transferase family 9
F0316_RS13070	COG0463	Glycosyl transferase, family 2
F0316_RS13075	COG0859	PFAM glycosyl transferase family 9
F0316_RS13080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0316_RS13085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0316_RS13095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0316_RS13100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0316_RS13105	COG2003	Belongs to the UPF0758 family
F0316_RS13115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F0316_RS13125	COG1309	transcriptional regulator
F0316_RS13130	COG1560	Kdo2-lipid A biosynthetic process
F0316_RS13135	COG1560	Kdo2-lipid A biosynthetic process
F0316_RS13140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0316_RS13145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F0316_RS13150	COG1561	YicC-like family, N-terminal region
F0316_RS13155	COG2862	Uncharacterized protein family, UPF0114
F0316_RS13160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0316_RS13160	COG1263	PTS System
F0316_RS13165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F0316_RS13190	COG1120	ATPase activity
F0316_RS13195	COG4774	siderophore transport
F0316_RS13200	COG1132	(ABC) transporter
F0316_RS13215	COG0514	ATP-dependent DNA helicase (RecQ)
F0316_RS13220	COG2962	Rard protein
F0316_RS13225	COG0405	Gamma-glutamyltransferase
F0316_RS13230	COG2207	Transcriptional regulator
F0316_RS13235	COG1280	lysine exporter protein (LysE YggA)
F0316_RS13250	COG0210	DNA helicase
F0316_RS13260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F0316_RS13265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0316_RS13275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0316_RS13280	COG0601	transmembrane transport
F0316_RS13285	COG0747	negative chemotaxis
F0316_RS13340	COG1309	transcriptional regulator
F0316_RS13345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0316_RS13350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0316_RS13355	COG2960	long-chain fatty acid transporting porin activity
F0316_RS13360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0316_RS13365	COG0583	DNA-binding transcription factor activity
F0316_RS13435	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
F0316_RS13440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0316_RS13445	COG1739	Uncharacterized protein family UPF0029
F0316_RS13450	COG1024	Enoyl-CoA hydratase
F0316_RS13450	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0316_RS13455	COG0183	Belongs to the thiolase family
F0316_RS13460	COG0583	DNA-binding transcription factor activity
F0316_RS13465	COG2814	Major facilitator Superfamily
F0316_RS13475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0316_RS13480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0316_RS13485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0316_RS13490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0316_RS13495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0316_RS13500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0316_RS13510	COG0356	it plays a direct role in the translocation of protons across the membrane
F0316_RS13515	COG3312	ion transport
F0316_RS13520	COG1475	DNA binding
F0316_RS13525	COG1192	Involved in chromosome partitioning
F0316_RS13530	COG0357	Ribosomal RNA small subunit methyltransferase G
F0316_RS13535	COG0445	tRNA wobble uridine modification
F0316_RS13545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0316_RS13550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0316_RS13555	COG0706	membrane insertase activity
F0316_RS13565	COG0594	ribonuclease P activity
F0316_RS13570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0316_RS13575	COG1126	abc transporter atp-binding protein
F0316_RS13590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0316_RS13595	COG0592	DNA-directed DNA polymerase activity
F0316_RS13600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0316_RS13605	COG0187	DNA topoisomerase II activity
F0316_RS13620	COG0071	Belongs to the small heat shock protein (HSP20) family
F0316_RS13625	COG3977	Valine--pyruvate aminotransferase
F0316_RS13635	COG0751	glycine-tRNA ligase activity
F0316_RS13640	COG0752	glycyl-tRNA synthetase alpha subunit
F0316_RS13645	COG2119	membrane
F0316_RS13660	COG0425	Belongs to the sulfur carrier protein TusA family
F0316_RS13670	COG0604	alcohol dehydrogenase
F0316_RS13680	COG0129	dihydroxy-acid dehydratase activity
F0316_RS13685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0316_RS13700	COG0606	chelatase, subunit chli
F0316_RS13705	COG0204	Acyl-transferase
F0316_RS13710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0316_RS13715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F0316_RS13725	COG3084	Protein conserved in bacteria
F0316_RS13735	COG4326	sporulation control protein
F0316_RS13740	COG1272	protein, Hemolysin III
F0316_RS13750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0316_RS13755	COG0569	domain protein
F0316_RS13760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0316_RS13760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0316_RS13765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0316_RS13770	COG0242	peptide deformylase activity
F0316_RS13775	COG1652	LysM domain
F0316_RS13780	COG0758	DNA mediated transformation
F0316_RS13785	COG2922	Belongs to the Smg family
F0316_RS13790	COG0551	DNA topoisomerase type I activity
F0316_RS13795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F0316_RS13800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0316_RS13805	COG0009	L-threonylcarbamoyladenylate synthase
F0316_RS13810	COG0408	coproporphyrinogen oxidase activity
F0316_RS13815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0316_RS13825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0316_RS13855	COG1475	DNA binding
F0316_RS14020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0316_RS14025	COG1475	DNA binding
F0316_RS14045	COG2885	chlorophyll binding
F0316_RS14130	COG2003	Belongs to the UPF0758 family
F0316_RS14150	COG3140	Belongs to the UPF0181 family
F0316_RS14160	COG1450	Type ii and iii secretion system protein
F0316_RS14205	COG0023	Translation Initiation Factor
F0316_RS14225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0316_RS14225	COG1042	CoA-binding domain protein
F0316_RS14225	COG0045	succinate-CoA ligase (ADP-forming) activity
F0316_RS14230	COG0583	DNA-binding transcription factor activity
F0316_RS14235	COG4771	TonB-dependent receptor
F0316_RS14250	COG2050	protein possibly involved in aromatic compounds catabolism
F0316_RS14275	COG0625	glutathione transferase activity
F0316_RS14290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0316_RS14295	COG4172	Belongs to the ABC transporter superfamily
F0316_RS14300	COG4239	(ABC) transporter, permease
F0316_RS14305	COG4174	ABC transporter (Permease)
F0316_RS14310	COG4166	transmembrane transport
F0316_RS14335	COG3104	oligopeptide transport
F0316_RS14355	COG3842	ATPase activity
F0316_RS14365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0316_RS14370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F0316_RS14375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0316_RS14380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0316_RS14385	COG1011	Hydrolase
F0316_RS14400	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F0316_RS14405	COG1970	mechanosensitive ion channel activity
F0316_RS14410	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F0316_RS14415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0316_RS14415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0316_RS14420	COG0302	gtp cyclohydrolase
F0316_RS14430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0316_RS14440	COG2897	thiosulfate sulfurtransferase activity
F0316_RS14450	COG2390	Transcriptional regulator
F0316_RS14465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0316_RS14485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0316_RS14495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0316_RS14520	COG0583	DNA-binding transcription factor activity
F0316_RS14525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0316_RS14570	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0316_RS14615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0316_RS14615	COG1263	PTS System
F0316_RS14620	COG1609	Transcriptional regulator
F0316_RS14630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0316_RS14635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0316_RS14650	COG0545	Peptidyl-prolyl cis-trans isomerase
F0316_RS14655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0316_RS14660	COG0840	transmembrane signaling receptor activity
F0316_RS14665	COG3069	C4-dicarboxylate transmembrane transporter activity
F0316_RS14670	COG1760	l-serine dehydratase
F0316_RS14690	COG1609	Transcriptional regulator
F0316_RS14695	COG2197	response regulator
F0316_RS14700	COG3850	Histidine kinase
F0316_RS14705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0316_RS14715	COG0243	molybdopterin cofactor binding
F0316_RS14735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0316_RS14740	COG2197	response regulator
F0316_RS14745	COG3851	Histidine kinase
F0316_RS14750	COG2271	Major facilitator Superfamily
F0316_RS14755	COG1840	ABC-type Fe3 transport system, periplasmic component
F0316_RS14765	COG3842	ATPase activity
F0316_RS14770	COG3243	poly(R)-hydroxyalkanoic acid synthase
F0316_RS14780	COG0183	Belongs to the thiolase family
F0316_RS14790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0316_RS14795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0316_RS14815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0316_RS14825	COG1979	alcohol dehydrogenase
F0316_RS14840	COG4191	Histidine kinase
F0316_RS14850	COG2271	Major facilitator Superfamily
F0316_RS14855	COG0469	pyruvate kinase activity
F0316_RS14860	COG2198	Histidine kinase
F0316_RS14860	COG0784	Response regulator, receiver
F0316_RS14860	COG2205	protein histidine kinase activity
F0316_RS14865	COG1879	ABC-type sugar transport system periplasmic component
F0316_RS14870	COG1803	Methylglyoxal synthase
F0316_RS14875	COG1335	isochorismatase
F0316_RS14880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F0316_RS14895	COG0210	DNA helicase
F0316_RS14900	COG1289	transmembrane transporter activity
F0316_RS14930	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F0316_RS14935	COG4149	molybdate abc transporter
F0316_RS14940	COG0725	ABC transporter, periplasmic molybdate-binding protein
F0316_RS14945	COG1492	cobalamin metabolic process
F0316_RS14950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0316_RS14955	COG0583	DNA-binding transcription factor activity
F0316_RS14985	COG0784	Response regulator, receiver
F0316_RS14985	COG5002	protein histidine kinase activity
F0316_RS14990	COG1879	ABC-type sugar transport system periplasmic component
F0316_RS15000	COG2827	Endonuclease containing a URI domain
F0316_RS15015	COG2926	Belongs to the UPF0265 family
F0316_RS15030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0316_RS15035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0316_RS15040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0316_RS15045	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
F0316_RS15050	COG0247	lactate metabolic process
F0316_RS15055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0316_RS15060	COG3118	belongs to the thioredoxin family
F0316_RS15090	COG4160	amino acid transport
F0316_RS15095	COG4215	(ABC) transporter
F0316_RS15100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0316_RS15105	COG1126	abc transporter atp-binding protein
F0316_RS15115	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0316_RS15125	COG0494	nUDIX hydrolase
F0316_RS15130	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F0316_RS15140	COG1309	transcriptional regulator
F0316_RS15145	COG0513	Belongs to the DEAD box helicase family
F0316_RS15150	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
F0316_RS15160	COG0814	amino acid
F0316_RS15165	COG0840	transmembrane signaling receptor activity
F0316_RS15170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0316_RS15180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F0316_RS15190	COG1984	allophanate hydrolase subunit 2
F0316_RS15205	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F0316_RS15210	COG4181	ATPase activity
F0316_RS15220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0316_RS15225	COG5001	Diguanylate cyclase
F0316_RS15225	COG1716	ATPase activity
F0316_RS15240	COG0484	heat shock protein binding
F0316_RS15255	COG0546	phosphoglycolate phosphatase activity
F0316_RS15270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0316_RS15275	COG1368	sulfuric ester hydrolase activity
F0316_RS15285	COG0513	Belongs to the DEAD box helicase family
F0316_RS15300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0316_RS15310	COG3046	protein related to deoxyribodipyrimidine photolyase
F0316_RS15315	COG3397	chitin binding
F0316_RS15320	COG3227	Zinc metalloprotease (Elastase)
F0316_RS15330	COG0010	Belongs to the arginase family
F0316_RS15335	COG1166	arginine decarboxylase activity
F0316_RS15345	COG2239	Acts as a magnesium transporter
F0316_RS15350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0316_RS15355	COG0459	protein refolding
F0316_RS15365	COG0527	aspartate kinase activity
F0316_RS15370	COG0662	Cupin 2, conserved barrel domain protein
F0316_RS15375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F0316_RS15380	COG0456	acetyltransferase
F0316_RS15390	COG2154	pterin-4-alpha-carbinolamine dehydratase
F0316_RS15395	COG3186	Phenylalanine-4-hydroxylase
F0316_RS15400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0316_RS15420	COG2264	protein methyltransferase activity
F0316_RS15445	COG1253	flavin adenine dinucleotide binding
F0316_RS15450	COG1765	OsmC-like protein
F0316_RS15480	COG0531	amino acid
F0316_RS15495	COG3279	Response regulator of the LytR AlgR family
F0316_RS15500	COG3275	phosphorelay sensor kinase activity
F0316_RS15515	COG1136	(ABC) transporter
F0316_RS15515	COG0577	efflux transmembrane transporter activity
F0316_RS15520	COG1136	(ABC) transporter
F0316_RS15535	COG4989	oxidoreductase activity
F0316_RS15540	COG0366	Alpha amylase catalytic
F0316_RS15550	COG2067	long-chain fatty acid transport protein
F0316_RS15555	COG2267	carboxylic ester hydrolase activity
F0316_RS15565	COG3227	Zinc metalloprotease (Elastase)
F0316_RS15575	COG3047	cAMP biosynthetic process
F0316_RS15585	COG1686	Belongs to the peptidase S11 family
F0316_RS15590	COG0557	exoribonuclease II activity
F0316_RS15595	COG1278	Cold shock
F0316_RS15605	COG3048	D-serine ammonia-lyase activity
F0316_RS15610	COG0583	DNA-binding transcription factor activity
F0316_RS15625	COG1063	alcohol dehydrogenase
F0316_RS15645	COG0583	DNA-binding transcription factor activity
F0316_RS15655	COG1028	Short-chain dehydrogenase reductase Sdr
F0316_RS15770	COG1447	Phosphotransferase system cellobiose-specific component IIA
F0316_RS15780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0316_RS15785	COG2723	6-phospho-beta-galactosidase activity
F0316_RS15790	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F0316_RS15790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F0316_RS15795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0316_RS15800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0316_RS15825	COG4626	Terminase
F0316_RS15825	COG1802	Transcriptional regulator
F0316_RS15855	COG0582	viral genome integration into host DNA
F0316_RS15880	COG1063	alcohol dehydrogenase
F0316_RS15890	COG2873	o-acetylhomoserine
F0316_RS15900	COG0346	lactoylglutathione lyase activity
F0316_RS15920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0316_RS15925	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0316_RS15930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F0316_RS15935	COG0363	glucosamine-6-phosphate deaminase activity
F0316_RS15940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0316_RS15965	COG1929	Belongs to the glycerate kinase type-1 family
F0316_RS15975	COG0748	coenzyme F420 binding
F0316_RS15980	COG3721	Heme iron utilization protein
F0316_RS15990	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0316_RS15995	COG0811	peptide transport
F0316_RS16000	COG0848	biopolymer transport protein
F0316_RS16005	COG4558	Periplasmic binding protein
F0316_RS16010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0316_RS16015	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0316_RS16050	COG0633	Ferredoxin
F0316_RS16050	COG0633	Ferredoxin
F0316_RS16050	COG3217	Mosc domain protein beta barrel domain protein
F0316_RS16050	COG3217	Mosc domain protein beta barrel domain protein
F0316_RS16055	COG0418	dihydroorotase activity
F0316_RS16065	COG3152	Membrane
F0316_RS16075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0316_RS16080	COG2354	Protein conserved in bacteria
F0316_RS16085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0316_RS16090	COG1278	Cold shock
F0316_RS16120	COG2199	diguanylate cyclase activity
F0316_RS16125	COG1349	DNA-binding transcription factor activity
F0316_RS16140	COG3833	ABC-type maltose transport systems, permease component
F0316_RS16145	COG1175	transmembrane transport
F0316_RS16155	COG3842	ATPase activity
F0316_RS16160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0316_RS16175	COG0393	Putative heavy-metal-binding
F0316_RS16185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0316_RS16190	COG0784	Response regulator, receiver
F0316_RS16190	COG0835	chemotaxis
F0316_RS16195	COG1846	Transcriptional regulator
F0316_RS16200	COG3706	GGDEF domain
F0316_RS16235	COG0583	DNA-binding transcription factor activity
F0316_RS16240	COG5001	Diguanylate cyclase
F0316_RS16250	COG1741	Belongs to the pirin family
F0316_RS16255	COG3123	guanosine phosphorylase activity
F0316_RS16265	COG2211	Major facilitator Superfamily
F0316_RS16275	COG0840	transmembrane signaling receptor activity
F0316_RS16280	COG1067	ATP-dependent peptidase activity
F0316_RS16290	COG4172	Belongs to the ABC transporter superfamily
F0316_RS16310	COG0583	DNA-binding transcription factor activity
F0316_RS16315	COG1620	l-lactate permease
F0316_RS16330	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F0316_RS16340	COG0840	transmembrane signaling receptor activity
F0316_RS16350	COG0513	Belongs to the DEAD box helicase family
F0316_RS16360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0316_RS16375	COG1132	(ABC) transporter
F0316_RS16385	COG1902	pentaerythritol trinitrate reductase activity
F0316_RS16395	COG1280	lysine exporter protein (LysE YggA)
F0316_RS16400	COG2207	Transcriptional regulator
F0316_RS16420	COG1846	Transcriptional regulator
F0316_RS16425	COG1764	response to oxidative stress
F0316_RS16430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0316_RS16435	COG0697	spore germination
F0316_RS16445	COG0700	Nucleoside recognition
F0316_RS16450	COG3366	ferrous iron transmembrane transporter activity
F0316_RS16455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F0316_RS16460	COG4565	transcriptional regulatory protein
F0316_RS16470	COG0471	metal ion transport
F0316_RS16480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0316_RS16485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F0316_RS16490	COG2259	Doxx family
F0316_RS16515	COG0363	glucosamine-6-phosphate deaminase activity
F0316_RS16530	COG4580	involved in the transport of maltose and maltodextrins
F0316_RS16545	COG0840	transmembrane signaling receptor activity
F0316_RS16560	COG0840	transmembrane signaling receptor activity
F0316_RS16570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0316_RS16575	COG1126	abc transporter atp-binding protein
F0316_RS16585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0316_RS16590	COG4597	amino acid ABC transporter
F0316_RS16595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0316_RS16600	COG2213	PTS system mannitol-specific
F0316_RS16600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0316_RS16605	COG0246	Mannitol dehydrogenase
F0316_RS16610	COG3722	fumarate hydratase activity
F0316_RS16640	COG0697	spore germination
F0316_RS16655	COG1335	isochorismatase
F0316_RS16665	COG2910	NAD(P)H-binding
F0316_RS16675	COG0840	transmembrane signaling receptor activity
F0316_RS16680	COG4221	oxidoreductase activity
F0316_RS16700	COG1901	pseudouridine methyltransferase
F0316_RS16710	COG0531	amino acid
F0316_RS16715	COG1982	Orn Lys Arg decarboxylase major
F0316_RS16745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0316_RS16770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0316_RS16810	COG0745	RESPONSE REGULATOR receiver
F0316_RS16835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0316_RS16840	COG0840	transmembrane signaling receptor activity
F0316_RS16845	COG0835	chemotaxis
F0316_RS16850	COG0835	chemotaxis
F0316_RS16855	COG2198	Histidine kinase
F0316_RS16855	COG0643	Histidine kinase
F0316_RS16875	COG0601	transmembrane transport
F0316_RS16880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0316_RS16890	COG2194	sulfuric ester hydrolase activity
F0316_RS16895	COG0642	Histidine kinase
F0316_RS16910	COG4221	oxidoreductase activity
F0316_RS16930	COG1444	tRNA N-acetyltransferase activity
F0316_RS16935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0316_RS16975	COG0217	transcriptional regulatory protein
F0316_RS16980	COG2084	Dehydrogenase
F0316_RS17000	COG2909	trisaccharide binding
F0316_RS17005	COG0058	SHG alpha-glucan phosphorylase activity
F0316_RS17010	COG1640	4-alpha-glucanotransferase
F0316_RS17015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0316_RS17030	COG3501	Rhs element vgr protein
F0316_RS17065	COG0471	metal ion transport
F0316_RS17070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
F0316_RS17115	COG0671	phosphoesterase, PA-phosphatase related
F0316_RS17125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F0316_RS17135	COG1999	signal sequence binding
F0316_RS17150	COG0786	glutamate:sodium symporter activity
F0316_RS17170	COG1566	PFAM secretion protein HlyD family protein
F0316_RS17195	COG0813	purine-nucleoside phosphorylase activity
F0316_RS17205	COG3272	Protein of unknown function (DUF1722)
F0316_RS17215	COG0415	Belongs to the DNA photolyase family
F0316_RS17220	COG1388	LysM domain
F0316_RS17220	COG1376	ErfK ybiS ycfS ynhG family protein
F0316_RS17230	COG0513	Belongs to the DEAD box helicase family
F0316_RS17235	COG1770	oligopeptidase
F0316_RS17265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0316_RS17270	COG0573	inorganic phosphate transmembrane transporter activity
F0316_RS17275	COG0581	inorganic phosphate transmembrane transporter activity
F0316_RS17280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0316_RS17300	COG3314	Sporulation integral membrane protein YlbJ
F0316_RS17305	COG0659	secondary active sulfate transmembrane transporter activity
F0316_RS17320	COG0739	heme binding
F0316_RS17325	COG5001	Diguanylate cyclase
F0316_RS17325	COG3300	MHYT domain
F0316_RS17330	COG0583	DNA-binding transcription factor activity
F0316_RS17335	COG2814	Major facilitator Superfamily
F0316_RS17340	COG0789	Transcriptional regulator
F0316_RS17360	COG1301	dicarboxylic acid transport
F0316_RS17375	COG1342	Belongs to the UPF0251 family
F0316_RS17415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F0316_RS17420	COG0673	inositol 2-dehydrogenase activity
F0316_RS17430	COG5001	Diguanylate cyclase
F0316_RS17430	COG3300	MHYT domain
F0316_RS17435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0316_RS17445	COG0564	pseudouridine synthase activity
F0316_RS17510	COG3829	transcription factor binding
F0316_RS17540	COG3501	Rhs element vgr protein
F0316_RS17540	COG3409	Peptidoglycan-binding domain 1 protein
F0316_RS17550	COG2801	Transposase and inactivated derivatives
F0316_RS17560	COG1869	D-ribose catabolic process
F0316_RS17565	COG1129	ABC transporter
F0316_RS17570	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0316_RS17575	COG1879	ABC-type sugar transport system periplasmic component
F0316_RS17580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0316_RS17585	COG1609	Transcriptional regulator
F0316_RS17595	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F0316_RS17605	COG0584	glycerophosphoryl diester phosphodiesterase
F0316_RS17610	COG2271	Major facilitator Superfamily
F0316_RS17650	COG0579	oxidoreductase
F0316_RS17660	COG0242	peptide deformylase activity
F0316_RS17675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0316_RS17680	COG1609	Transcriptional regulator
F0316_RS17690	COG1320	monovalent cation:proton antiporter activity
F0316_RS17695	COG2212	antiporter activity
F0316_RS17700	COG1863	multisubunit Na H antiporter MnhE subunit
F0316_RS17705	COG0651	ATP synthesis coupled electron transport
F0316_RS17710	COG1006	Multisubunit Na H antiporter MnhC subunit
F0316_RS17715	COG2111	Na H antiporter
F0316_RS17715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0316_RS17725	COG0589	response to stress
F0316_RS17730	COG0814	amino acid
F0316_RS17745	COG3530	Putative quorum-sensing-regulated virulence factor
F0316_RS17755	COG5002	protein histidine kinase activity
F0316_RS17755	COG5001	Diguanylate cyclase
F0316_RS17760	COG1278	Cold shock
F0316_RS17775	COG2304	oxidoreductase activity
F0316_RS17795	COG0714	Associated with various cellular activities
F0316_RS17800	COG0840	transmembrane signaling receptor activity
F0316_RS17815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0316_RS17820	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0316_RS17830	COG3604	Transcriptional regulator
F0316_RS17835	COG1017	nitric oxide dioxygenase activity
F0316_RS17835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0316_RS17840	COG1278	Cold shock
F0316_RS17845	COG3036	rescue of stalled ribosome
F0316_RS17870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0316_RS17870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F0316_RS17875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0316_RS17885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0316_RS17900	COG0516	GMP reductase activity
F0316_RS17905	COG0513	Belongs to the DEAD box helicase family
F0316_RS17910	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0316_RS17915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0316_RS17920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0316_RS17925	COG3437	response regulator, receiver
F0316_RS17925	COG0784	Response regulator, receiver
F0316_RS17930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0316_RS17930	COG4191	Histidine kinase
F0316_RS17940	COG1757	Na H antiporter
F0316_RS17945	COG2814	Major facilitator Superfamily
F0316_RS17955	COG3706	GGDEF domain
F0316_RS17960	COG3240	lipase activity
F0316_RS17970	COG0840	transmembrane signaling receptor activity
F0316_RS17975	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F0316_RS17980	COG5380	lipid catabolic process
F0316_RS18005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0316_RS18010	COG4605	iron ion homeostasis
F0316_RS18015	COG4604	ABC transporter, ATP-binding protein
F0316_RS18020	COG2207	Transcriptional regulator
F0316_RS18035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0316_RS18060	COG0745	RESPONSE REGULATOR receiver
F0316_RS18070	COG3623	hexulose-6-phosphate isomerase
F0316_RS18075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F0316_RS18080	COG0561	phosphatase activity
F0316_RS18115	COG0366	Alpha amylase catalytic
F0316_RS18135	COG0745	RESPONSE REGULATOR receiver
F0316_RS18155	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0316_RS18190	COG1686	Belongs to the peptidase S11 family
F0316_RS18210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0316_RS18210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0316_RS18215	COG0509	glycine decarboxylation via glycine cleavage system
F0316_RS18220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0316_RS18230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0316_RS18245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0316_RS18250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0316_RS18375	COG2801	Transposase and inactivated derivatives
F0316_RS18395	COG2801	Transposase and inactivated derivatives
F0316_RS18510	COG5642	Protein of unknown function (DUF2384)
F0316_RS18620	COG2801	Transposase and inactivated derivatives
F0316_RS18725	COG1418	mRNA catabolic process
F0316_RS18755	COG0384	phenazine biosynthesis protein PhzF
F0316_RS18795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0316_RS18870	COG3040	lipid binding
F0316_RS18875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0316_RS18980	COG2161	toxin-antitoxin pair type II binding
F0316_RS18985	COG4115	mRNA cleavage
F0316_RS19090	COG3549	Plasmid maintenance system killer
F0316_RS19095	COG3093	addiction module antidote protein HigA
F0316_RS19145	COG2801	Transposase and inactivated derivatives
F0316_RS19180	COG4122	O-methyltransferase activity
F0316_RS19300	COG4977	sequence-specific DNA binding
F0316_RS19310	COG0384	phenazine biosynthesis protein PhzF
F0316_RS19390	COG0346	lactoylglutathione lyase activity
F0316_RS19550	COG1328	CTP reductase activity
F0316_RS19555	COG0602	queuosine metabolic process
F0316_RS19565	COG4067	protein conserved in archaea
F0316_RS19565	COG0189	ligase activity
F0316_RS19570	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F0316_RS19570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0316_RS19570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0316_RS19575	COG1105	Belongs to the carbohydrate kinase PfkB family
F0316_RS19580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0316_RS19580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0316_RS19585	COG1609	Transcriptional regulator
F0316_RS19590	COG0420	3'-5' exonuclease activity
F0316_RS19595	COG0419	ATPase involved in DNA repair
F0316_RS19600	COG0784	Response regulator, receiver
F0316_RS19600	COG2205	protein histidine kinase activity
F0316_RS19610	COG0156	8-amino-7-oxononanoate synthase activity
F0316_RS19620	COG0038	chloride channel
F0316_RS19625	COG0523	cobalamin synthesis protein
F0316_RS19635	COG3158	transport of potassium into the cell
F0316_RS19640	COG0674	pyruvate-flavodoxin oxidoreductase activity
F0316_RS19640	COG1013	pyruvate-flavodoxin oxidoreductase activity
F0316_RS19640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F0316_RS19640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0316_RS19645	COG2205	protein histidine kinase activity
F0316_RS19650	COG0745	RESPONSE REGULATOR receiver
F0316_RS19655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0316_RS19660	COG0586	Pfam SNARE associated Golgi protein
F0316_RS19670	COG2200	EAL domain
F0316_RS19680	COG3038	cytochrome b561
F0316_RS19690	COG2116	formate transmembrane transporter activity
F0316_RS19695	COG0583	DNA-binding transcription factor activity
F0316_RS19705	COG3593	DNA synthesis involved in DNA repair
F0316_RS19710	COG0737	Belongs to the 5'-nucleotidase family
F0316_RS19725	COG2824	Alkylphosphonate utilization operon protein PhnA
F0316_RS19760	COG2199	diguanylate cyclase activity
F0316_RS19795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F0316_RS19800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane