locus-tag	class	description
HPY11_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY11_RS00010	COG0592	DNA-directed DNA polymerase activity
HPY11_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY11_RS00020	COG0187	DNA topoisomerase II activity
HPY11_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY11_RS00035	COG3977	Valine--pyruvate aminotransferase
HPY11_RS00040	COG0751	glycine-tRNA ligase activity
HPY11_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY11_RS00050	COG2119	membrane
HPY11_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY11_RS00070	COG0604	alcohol dehydrogenase
HPY11_RS00080	COG0129	dihydroxy-acid dehydratase activity
HPY11_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY11_RS00100	COG0606	chelatase, subunit chli
HPY11_RS00105	COG0204	Acyl-transferase
HPY11_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY11_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY11_RS00125	COG3084	Protein conserved in bacteria
HPY11_RS00130	COG4326	sporulation control protein
HPY11_RS00135	COG1272	protein, Hemolysin III
HPY11_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY11_RS00150	COG0569	domain protein
HPY11_RS00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY11_RS00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY11_RS00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY11_RS00165	COG0242	peptide deformylase activity
HPY11_RS00170	COG1652	LysM domain
HPY11_RS00175	COG0758	DNA mediated transformation
HPY11_RS00180	COG2922	Belongs to the Smg family
HPY11_RS00185	COG0551	DNA topoisomerase type I activity
HPY11_RS00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY11_RS00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY11_RS00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY11_RS00205	COG0408	coproporphyrinogen oxidase activity
HPY11_RS00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY11_RS00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY11_RS00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY11_RS00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY11_RS00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY11_RS00280	COG2104	thiamine diphosphate biosynthetic process
HPY11_RS00285	COG2022	thiamine diphosphate biosynthetic process
HPY11_RS00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY11_RS00295	COG0006	proline dipeptidase activity
HPY11_RS00295	COG0006	proline dipeptidase activity
HPY11_RS00315	COG1522	sequence-specific DNA binding
HPY11_RS00320	COG5002	protein histidine kinase activity
HPY11_RS00320	COG5001	Diguanylate cyclase
HPY11_RS00340	COG0589	response to stress
HPY11_RS00345	COG1528	Iron-storage protein
HPY11_RS00355	COG2081	HI0933 family
HPY11_RS00365	COG1322	Protein conserved in bacteria
HPY11_RS00370	COG2226	methyltransferase
HPY11_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY11_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY11_RS00395	COG0805	protein transport
HPY11_RS00400	COG0534	Mate efflux family protein
HPY11_RS00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY11_RS00415	COG2937	Belongs to the GPAT DAPAT family
HPY11_RS00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY11_RS00425	COG3161	chorismate lyase activity
HPY11_RS00430	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY11_RS00435	COG0840	transmembrane signaling receptor activity
HPY11_RS00445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY11_RS00450	COG0084	hydrolase, TatD family'
HPY11_RS00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY11_RS00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY11_RS00485	COG3078	GTPase activator activity
HPY11_RS00500	COG3071	HemY protein
HPY11_RS00505	COG2959	enzyme of heme biosynthesis
HPY11_RS00510	COG1587	Uroporphyrinogen-III synthase
HPY11_RS00515	COG0181	hydroxymethylbilane synthase activity
HPY11_RS00525	COG1965	Belongs to the frataxin family
HPY11_RS00535	COG0019	diaminopimelate decarboxylase activity
HPY11_RS00540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY11_RS00550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY11_RS00555	COG1011	Hydrolase
HPY11_RS00560	COG3287	FIST C domain
HPY11_RS00560	COG2200	EAL domain
HPY11_RS00560	COG2199	diguanylate cyclase activity
HPY11_RS00575	COG0561	phosphatase activity
HPY11_RS00580	COG2267	carboxylic ester hydrolase activity
HPY11_RS00585	COG1280	lysine exporter protein (LysE YggA)
HPY11_RS00590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY11_RS00595	COG0783	Belongs to the Dps family
HPY11_RS00625	COG0742	ribosomal rna small subunit methyltransferase
HPY11_RS00630	COG0552	protein localization to endoplasmic reticulum
HPY11_RS00635	COG2884	Cell division ATP-binding protein ftsE
HPY11_RS00640	COG2177	Part of the ABC transporter FtsEX involved in
HPY11_RS00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY11_RS00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_RS00740	COG2003	Belongs to the UPF0758 family
HPY11_RS00775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY11_RS00785	COG1404	Belongs to the peptidase S8 family
HPY11_RS00790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY11_RS00855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY11_RS00860	COG5001	Diguanylate cyclase
HPY11_RS00860	COG3300	MHYT domain
HPY11_RS00870	COG3852	Histidine kinase
HPY11_RS00880	COG0174	glutamine synthetase
HPY11_RS00900	COG1295	ribonuclease BN
HPY11_RS00905	COG1490	D-aminoacyl-tRNA deacylase activity
HPY11_RS00910	COG0456	acetyltransferase
HPY11_RS00920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY11_RS00925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY11_RS00930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY11_RS00935	COG3031	protein transport across the cell outer membrane
HPY11_RS00945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY11_RS00950	COG1459	type II secretion system
HPY11_RS00955	COG2165	general secretion pathway protein
HPY11_RS00960	COG2165	general secretion pathway protein
HPY11_RS00965	COG2165	general secretion pathway protein
HPY11_RS00970	COG4795	General secretion pathway protein
HPY11_RS00975	COG3156	type II secretion system protein K
HPY11_RS00980	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY11_RS00985	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY11_RS00995	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY11_RS01000	COG0494	nUDIX hydrolase
HPY11_RS01010	COG1040	competence protein
HPY11_RS01020	COG0596	Alpha beta hydrolase
HPY11_RS01030	COG2183	response to ionizing radiation
HPY11_RS01070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY11_RS01075	COG2199	diguanylate cyclase activity
HPY11_RS01080	COG0745	RESPONSE REGULATOR receiver
HPY11_RS01090	COG2233	PERMEase
HPY11_RS01095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY11_RS01100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY11_RS01105	COG1758	RNA polymerase activity
HPY11_RS01110	COG0194	GDP metabolic process
HPY11_RS01115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY11_RS01120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY11_RS01140	COG4232	protein-disulfide reductase activity
HPY11_RS01150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY11_RS01155	COG1027	Aspartate ammonia-lyase
HPY11_RS01160	COG3706	GGDEF domain
HPY11_RS01165	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY11_RS01170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY11_RS01180	COG2205	protein histidine kinase activity
HPY11_RS01185	COG0745	RESPONSE REGULATOR receiver
HPY11_RS01195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY11_RS01200	COG0205	6-phosphofructokinase activity
HPY11_RS01205	COG1494	fructose-1,6-bisphosphatase
HPY11_RS01210	COG3074	FtsZ-dependent cytokinesis
HPY11_RS01215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY11_RS01220	COG0460	homoserine dehydrogenase
HPY11_RS01220	COG0527	aspartate kinase activity
HPY11_RS01225	COG0626	cystathionine gamma-synthase activity
HPY11_RS01230	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY11_RS01235	COG0281	malic enzyme
HPY11_RS01240	COG0254	rRNA binding
HPY11_RS01245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY11_RS01250	COG1609	Transcriptional regulator
HPY11_RS01255	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY11_RS01260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY11_RS01265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY11_RS01270	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY11_RS01275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY11_RS01280	COG0534	Mate efflux family protein
HPY11_RS01285	COG0149	triose-phosphate isomerase activity
HPY11_RS01310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY11_RS01315	COG0459	protein refolding
HPY11_RS01325	COG1509	lysine 2,3-aminomutase activity
HPY11_RS01330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY11_RS01340	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY11_RS01345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY11_RS01350	COG1053	succinate dehydrogenase
HPY11_RS01355	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY11_RS01360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY11_RS01365	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY11_RS01370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY11_RS01375	COG1045	serine acetyltransferase
HPY11_RS01385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY11_RS01390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY11_RS01395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY11_RS01400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY11_RS01405	COG0137	argininosuccinate synthase activity
HPY11_RS01410	COG0165	Argininosuccinate lyase
HPY11_RS01420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_RS01425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY11_RS01425	COG0678	peroxiredoxin activity
HPY11_RS01435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY11_RS01465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY11_RS01470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY11_RS01480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY11_RS01485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY11_RS01490	COG0546	phosphoglycolate phosphatase activity
HPY11_RS01495	COG0180	Tryptophanyl-tRNA synthetase
HPY11_RS01515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY11_RS01525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY11_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_RS01550	COG3954	Phosphoribulokinase
HPY11_RS01560	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY11_RS01570	COG0488	(ABC) transporter
HPY11_RS01575	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY11_RS01590	COG1047	Peptidyl-prolyl cis-trans
HPY11_RS01600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY11_RS01605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY11_RS01610	COG3083	sulfuric ester hydrolase activity
HPY11_RS01615	COG0557	exoribonuclease II activity
HPY11_RS01620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY11_RS01625	COG0051	transcription antitermination factor activity, RNA binding
HPY11_RS01630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY11_RS01635	COG0088	Forms part of the polypeptide exit tunnel
HPY11_RS01640	COG0089	rRNA binding
HPY11_RS01645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY11_RS01650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY11_RS01655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY11_RS01660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY11_RS01665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY11_RS01670	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY11_RS01675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY11_RS01680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY11_RS01685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY11_RS01690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY11_RS01695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY11_RS01700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY11_RS01705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY11_RS01710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY11_RS01715	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY11_RS01720	COG1841	ribosomal large subunit assembly
HPY11_RS01730	COG0201	protein transport
HPY11_RS01735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY11_RS01740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY11_RS01745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY11_RS01750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY11_RS01755	COG0202	RNA polymerase activity
HPY11_RS01760	COG0203	ribosomal protein L17
HPY11_RS01770	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY11_RS01775	COG3061	Opacity-associated protein A
HPY11_RS01775	COG3266	domain, Protein
HPY11_RS01780	COG0697	spore germination
HPY11_RS01785	COG2153	protein acetylation
HPY11_RS01790	COG0513	Belongs to the DEAD box helicase family
HPY11_RS01800	COG0737	Belongs to the 5'-nucleotidase family
HPY11_RS01805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY11_RS01805	COG1648	precorrin-2 dehydrogenase activity
HPY11_RS01810	COG0175	sulfate reduction
HPY11_RS01815	COG2895	sulfate adenylyltransferase (ATP) activity
HPY11_RS01820	COG0529	Catalyzes the synthesis of activated sulfate
HPY11_RS01840	COG1136	(ABC) transporter
HPY11_RS01855	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY11_RS01860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_RS01865	COG0729	surface antigen
HPY11_RS01875	COG2105	PFAM AIG2 family protein
HPY11_RS01880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY11_RS01890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY11_RS01895	COG0163	prenyltransferase activity
HPY11_RS01905	COG1178	ABC-type Fe3 transport system permease component
HPY11_RS01910	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY11_RS01915	COG3028	Belongs to the UPF0307 family
HPY11_RS01920	COG0312	modulator of DNA gyrase
HPY11_RS01925	COG2239	Acts as a magnesium transporter
HPY11_RS01930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_RS01935	COG1660	Displays ATPase and GTPase activities
HPY11_RS01940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_RS01945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY11_RS01955	COG1137	ATPase activity
HPY11_RS01960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY11_RS01975	COG0517	IMP dehydrogenase activity
HPY11_RS01975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY11_RS01985	COG1127	ABC transporter
HPY11_RS01990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY11_RS01995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY11_RS02000	COG2854	intermembrane phospholipid transfer
HPY11_RS02010	COG5007	Belongs to the BolA IbaG family
HPY11_RS02015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY11_RS02025	COG0251	oxidation-reduction process
HPY11_RS02035	COG0540	Belongs to the ATCase OTCase family
HPY11_RS02045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY11_RS02050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY11_RS02055	COG0564	pseudouridine synthase activity
HPY11_RS02060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY11_RS02065	COG0525	valine-tRNA ligase activity
HPY11_RS02070	COG2927	DNA polymerase III (CHI subunit)
HPY11_RS02075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY11_RS02080	COG0795	lipopolysaccharide-transporting ATPase activity
HPY11_RS02085	COG0795	lipopolysaccharide-transporting ATPase activity
HPY11_RS02100	COG3437	response regulator, receiver
HPY11_RS02140	COG0066	3-isopropylmalate dehydratase activity
HPY11_RS02145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY11_RS02150	COG0473	3-isopropylmalate dehydrogenase activity
HPY11_RS02170	COG0583	DNA-binding transcription factor activity
HPY11_RS02175	COG1022	Amp-dependent synthetase and ligase
HPY11_RS02180	COG0028	Belongs to the TPP enzyme family
HPY11_RS02185	COG0440	acetolactate synthase activity
HPY11_RS02190	COG3385	transposase activity
HPY11_RS02195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY11_RS02200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY11_RS02205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY11_RS02215	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY11_RS02220	COG3079	Belongs to the UPF0149 family
HPY11_RS02225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_RS02230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_RS02245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY11_RS02255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY11_RS02260	COG1595	DNA-templated transcription, initiation
HPY11_RS02275	COG3086	response to oxidative stress
HPY11_RS02280	COG0481	GTPase activity
HPY11_RS02290	COG0571	ribonuclease III activity
HPY11_RS02295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY11_RS02300	COG1381	Involved in DNA repair and RecF pathway recombination
HPY11_RS02305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY11_RS02340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY11_RS02345	COG3956	TIGRFAM MazG family protein
HPY11_RS02350	COG0504	CTP synthase activity
HPY11_RS02355	COG0148	phosphopyruvate hydratase activity
HPY11_RS02365	COG3267	Type II secretory pathway component ExeA
HPY11_RS02365	COG3409	Peptidoglycan-binding domain 1 protein
HPY11_RS02375	COG4991	sh3 domain protein
HPY11_RS02380	COG0306	phosphate transporter
HPY11_RS02385	COG1392	Phosphate transport regulator
HPY11_RS02390	COG3025	triphosphatase activity
HPY11_RS02395	COG0840	transmembrane signaling receptor activity
HPY11_RS02400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY11_RS02405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY11_RS02405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY11_RS02410	COG1538	Outer membrane efflux protein
HPY11_RS02415	COG0494	nUDIX hydrolase
HPY11_RS02420	COG3151	Protein conserved in bacteria
HPY11_RS02430	COG3150	esterase
HPY11_RS02435	COG0187	DNA topoisomerase II activity
HPY11_RS02440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY11_RS02450	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY11_RS02455	COG0237	dephospho-CoA kinase activity
HPY11_RS02465	COG1459	type II secretion system
HPY11_RS02470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY11_RS02490	COG0716	FMN binding
HPY11_RS02495	COG4974	Belongs to the 'phage' integrase family
HPY11_RS02500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY11_RS02505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY11_RS02510	COG2186	Transcriptional regulator
HPY11_RS02515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY11_RS02520	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY11_RS02525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_RS02540	COG3116	cell division
HPY11_RS02545	COG0768	penicillin binding
HPY11_RS02550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY11_RS02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY11_RS02565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY11_RS02570	COG0772	Belongs to the SEDS family
HPY11_RS02575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY11_RS02580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY11_RS02585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY11_RS02590	COG0849	cell division
HPY11_RS02595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY11_RS02600	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY11_RS02610	COG0653	protein targeting
HPY11_RS02615	COG0494	nUDIX hydrolase
HPY11_RS02620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY11_RS02630	COG0505	Belongs to the CarA family
HPY11_RS02635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY11_RS02650	COG0730	response to heat
HPY11_RS02655	COG0583	DNA-binding transcription factor activity
HPY11_RS02660	COG2860	membrane
HPY11_RS02665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY11_RS02675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY11_RS02685	COG0493	'glutamate synthase
HPY11_RS02690	COG0067	glutamate synthase
HPY11_RS02690	COG0070	glutamate synthase
HPY11_RS02690	COG0069	glutamate synthase activity
HPY11_RS02700	COG0067	glutamate synthase
HPY11_RS02700	COG0069	glutamate synthase activity
HPY11_RS02700	COG0070	glutamate synthase
HPY11_RS02705	COG1242	4 iron, 4 sulfur cluster binding
HPY11_RS02710	COG2203	Gaf domain
HPY11_RS02710	COG4251	negative regulation of phosphorylation
HPY11_RS02710	COG5001	Diguanylate cyclase
HPY11_RS02710	COG3706	GGDEF domain
HPY11_RS02715	COG0784	Response regulator, receiver
HPY11_RS02715	COG2198	Histidine kinase
HPY11_RS02715	COG5002	protein histidine kinase activity
HPY11_RS02720	COG0745	RESPONSE REGULATOR receiver
HPY11_RS02730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY11_RS02750	COG0083	homoserine kinase activity
HPY11_RS02755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY11_RS02760	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY11_RS02765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY11_RS02770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY11_RS02785	COG1115	amino acid carrier protein
HPY11_RS02790	COG3022	response to hydroperoxide
HPY11_RS02800	COG0084	hydrolase, TatD family'
HPY11_RS02805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY11_RS02815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY11_RS02820	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY11_RS02825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY11_RS02830	COG0813	purine-nucleoside phosphorylase activity
HPY11_RS02840	COG0560	Phosphoserine phosphatase
HPY11_RS02850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY11_RS02855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY11_RS02860	COG1022	Amp-dependent synthetase and ligase
HPY11_RS02875	COG3250	beta-galactosidase activity
HPY11_RS02885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_RS02900	COG0189	ligase activity
HPY11_RS02900	COG0569	domain protein
HPY11_RS02905	COG0456	acetyltransferase
HPY11_RS02915	COG2171	N-acyltransferase activity
HPY11_RS02920	COG3141	response to X-ray
HPY11_RS02935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY11_RS02940	COG1074	ATP-dependent DNA helicase activity
HPY11_RS02945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY11_RS02955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY11_RS02955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY11_RS02965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY11_RS02970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY11_RS02975	COG2166	iron-sulfur cluster assembly
HPY11_RS02980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY11_RS02985	COG0693	protein deglycase activity
HPY11_RS02990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY11_RS02995	COG3248	Nucleoside-binding outer membrane protein
HPY11_RS03005	COG1595	DNA-templated transcription, initiation
HPY11_RS03015	COG2211	Major facilitator Superfamily
HPY11_RS03030	COG2813	Specifically methylates the guanine in position
HPY11_RS03035	COG0271	Belongs to the BolA IbaG family
HPY11_RS03045	COG1805	sodium ion transport
HPY11_RS03050	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY11_RS03055	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY11_RS03060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY11_RS03065	COG2871	sodium ion transport
HPY11_RS03070	COG1477	protein flavinylation
HPY11_RS03090	COG3706	GGDEF domain
HPY11_RS03095	COG0733	neurotransmitter:sodium symporter activity
HPY11_RS03105	COG0189	ligase activity
HPY11_RS03110	COG0189	ligase activity
HPY11_RS03110	COG4067	protein conserved in archaea
HPY11_RS03115	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY11_RS03120	COG2252	PERMEase
HPY11_RS03125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY11_RS03140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY11_RS03145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY11_RS03150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY11_RS03155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_RS03155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_RS03170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY11_RS03175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY11_RS03180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY11_RS03185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY11_RS03195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY11_RS03200	COG0024	Methionine aminopeptidase
HPY11_RS03205	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY11_RS03210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY11_RS03215	COG0528	UMP kinase activity
HPY11_RS03220	COG0233	cytoplasmic translational termination
HPY11_RS03225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY11_RS03230	COG0575	Belongs to the CDS family
HPY11_RS03235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY11_RS03240	COG0750	zinc metalloprotease
HPY11_RS03250	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY11_RS03255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_RS03260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY11_RS03265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_RS03270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_RS03275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY11_RS03280	COG0587	DNA-directed DNA polymerase activity
HPY11_RS03285	COG0825	malonyl-CoA metabolic process
HPY11_RS03290	COG0037	tRNA processing
HPY11_RS03300	COG3479	Phenolic acid decarboxylase
HPY11_RS03305	COG0347	Belongs to the P(II) protein family
HPY11_RS03310	COG3021	interspecies interaction between organisms
HPY11_RS03315	COG1388	LysM domain
HPY11_RS03315	COG0741	lytic transglycosylase activity
HPY11_RS03320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY11_RS03325	COG2226	methyltransferase
HPY11_RS03330	COG0328	RNA-DNA hybrid ribonuclease activity
HPY11_RS03345	COG1960	acyl-CoA dehydrogenase activity
HPY11_RS03350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY11_RS03355	COG0121	glutamine amidotransferase
HPY11_RS03360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY11_RS03365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY11_RS03370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY11_RS03375	COG3706	GGDEF domain
HPY11_RS03380	COG1187	pseudouridine synthase activity
HPY11_RS03385	COG2840	Smr protein MutS2
HPY11_RS03400	COG3735	TraB family
HPY11_RS03415	COG2217	Heavy metal translocating P-type atpase
HPY11_RS03415	COG2608	mercury ion transmembrane transporter activity
HPY11_RS03420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY11_RS03435	COG4774	siderophore transport
HPY11_RS03435	COG1629	transport
HPY11_RS03440	COG2375	cellular response to nickel ion
HPY11_RS03445	COG3433	isochorismatase activity
HPY11_RS03445	COG2226	methyltransferase
HPY11_RS03445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY11_RS03480	COG0784	Response regulator, receiver
HPY11_RS03480	COG0835	chemotaxis
HPY11_RS03485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY11_RS03490	COG1815	bacterial-type flagellum-dependent cell motility
HPY11_RS03505	COG1749	Flagellar hook protein flgE
HPY11_RS03510	COG4787	bacterial-type flagellum-dependent cell motility
HPY11_RS03520	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY11_RS03525	COG1706	bacterial-type flagellum-dependent cell motility
HPY11_RS03530	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY11_RS03530	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY11_RS03545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_RS03550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_RS03635	COG0012	GTP binding
HPY11_RS03640	COG0193	aminoacyl-tRNA hydrolase activity
HPY11_RS03645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY11_RS03650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY11_RS03655	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY11_RS03660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY11_RS03665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY11_RS03670	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY11_RS03680	COG2912	Transglutaminase-like superfamily
HPY11_RS03685	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY11_RS03690	COG0737	Belongs to the 5'-nucleotidase family
HPY11_RS03695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY11_RS03700	COG2233	PERMEase
HPY11_RS03720	COG1393	Belongs to the ArsC family
HPY11_RS03725	COG4783	chaperone-mediated protein folding
HPY11_RS03745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY11_RS03760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY11_RS03770	COG1876	peptidase activity
HPY11_RS03780	COG1393	Belongs to the ArsC family
HPY11_RS03800	COG2837	iron assimilation
HPY11_RS03805	COG2706	6-phosphogluconolactonase activity
HPY11_RS03815	COG0800	Aldolase
HPY11_RS03825	COG4145	pantothenate transmembrane transporter activity
HPY11_RS03835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPY11_RS03845	COG0837	glucose binding
HPY11_RS03845	COG1737	Transcriptional regulator
HPY11_RS03850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_RS03855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_RS03860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY11_RS03865	COG1334	flagellar protein FlaG
HPY11_RS03870	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY11_RS03880	COG1516	flagellar protein fliS
HPY11_RS03890	COG4191	Histidine kinase
HPY11_RS03900	COG1677	Flagellar hook-basal body complex protein FliE
HPY11_RS03910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY11_RS03940	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY11_RS03965	COG1987	bacterial-type flagellum assembly
HPY11_RS03970	COG1684	flagellar biosynthetic protein fliR
HPY11_RS03980	COG2840	Smr protein MutS2
HPY11_RS03985	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY11_RS03990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY11_RS03995	COG2860	membrane
HPY11_RS04000	COG3101	peptidyl-lysine hydroxylation
HPY11_RS04010	COG0431	NADPH-dependent FMN reductase
HPY11_RS04015	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY11_RS04015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY11_RS04020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY11_RS04025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY11_RS04030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY11_RS04035	COG0735	belongs to the Fur family
HPY11_RS04045	COG0583	DNA-binding transcription factor activity
HPY11_RS04055	COG1346	cytolysis
HPY11_RS04070	COG0596	Alpha beta hydrolase
HPY11_RS04075	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY11_RS04080	COG0033	Phosphoglucomutase
HPY11_RS04090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY11_RS04095	COG0372	Belongs to the citrate synthase family
HPY11_RS04100	COG2009	succinate dehydrogenase
HPY11_RS04105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY11_RS04110	COG1053	succinate dehydrogenase
HPY11_RS04120	COG0567	Dehydrogenase, E1 component
HPY11_RS04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY11_RS04130	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY11_RS04140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY11_RS04145	COG1121	(ABC) transporter
HPY11_RS04150	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY11_RS04155	COG4977	sequence-specific DNA binding
HPY11_RS04160	COG1918	ferrous iron import across plasma membrane
HPY11_RS04180	COG0018	arginyl-trna synthetase
HPY11_RS04190	COG1025	Belongs to the peptidase M16 family
HPY11_RS04195	COG2062	phosphohistidine phosphatase, SixA
HPY11_RS04225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY11_RS04230	COG0643	Histidine kinase
HPY11_RS04230	COG0784	Response regulator, receiver
HPY11_RS04230	COG2198	Histidine kinase
HPY11_RS04235	COG2201	protein-glutamate methylesterase activity
HPY11_RS04240	COG1192	Involved in chromosome partitioning
HPY11_RS04250	COG0835	chemotaxis
HPY11_RS04260	COG4133	protoheme IX ABC transporter activity
HPY11_RS04265	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY11_RS04270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY11_RS04280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY11_RS04285	COG1138	Cytochrome C-type biogenesis protein
HPY11_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY11_RS04295	COG4235	cytochrome complex assembly
HPY11_RS04295	COG3088	subunit of a heme lyase
HPY11_RS04305	COG2853	Lipoprotein
HPY11_RS04325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY11_RS04330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY11_RS04335	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY11_RS04350	COG3083	sulfuric ester hydrolase activity
HPY11_RS04355	COG3082	Protein of unknown function (DUF1414)
HPY11_RS04360	COG3081	Nucleoid-associated protein
HPY11_RS04370	COG1757	Na H antiporter
HPY11_RS04375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY11_RS04380	COG2095	MarC family integral membrane protein
HPY11_RS04385	COG1454	alcohol dehydrogenase
HPY11_RS04385	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_RS04395	COG0659	secondary active sulfate transmembrane transporter activity
HPY11_RS04400	COG1530	ribonuclease E activity
HPY11_RS04405	COG0564	pseudouridine synthase activity
HPY11_RS04410	COG0424	maF-like protein
HPY11_RS04415	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY11_RS04420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY11_RS04425	COG0416	fatty acid biosynthetic process
HPY11_RS04430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY11_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_RS04445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY11_RS04450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY11_RS04455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY11_RS04460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY11_RS04465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY11_RS04475	COG0084	hydrolase, TatD family'
HPY11_RS04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_RS04480	COG1263	PTS System
HPY11_RS04490	COG0733	neurotransmitter:sodium symporter activity
HPY11_RS04505	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY11_RS04515	COG1940	carbohydrate kinase activity
HPY11_RS04520	COG0784	Response regulator, receiver
HPY11_RS04520	COG0835	chemotaxis
HPY11_RS04535	COG2226	methyltransferase
HPY11_RS04545	COG0676	glucose-6-phosphate 1-epimerase activity
HPY11_RS04550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY11_RS04555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_RS04565	COG3139	Protein of unknown function (DUF1315)
HPY11_RS04570	COG0252	asparaginase activity
HPY11_RS04575	COG0616	signal peptide processing
HPY11_RS04580	COG1902	pentaerythritol trinitrate reductase activity
HPY11_RS04580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY11_RS04585	COG0788	formyltetrahydrofolate deformylase activity
HPY11_RS04595	COG1199	ATP-dependent helicase activity
HPY11_RS04600	COG1214	PFAM Peptidase M22, glycoprotease
HPY11_RS04615	COG0596	Alpha beta hydrolase
HPY11_RS04620	COG0318	PFAM AMP-dependent synthetase and ligase
HPY11_RS04625	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY11_RS04640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY11_RS04645	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY11_RS04650	COG0436	Aminotransferase
HPY11_RS04655	COG1169	isochorismate synthase
HPY11_RS04660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY11_RS04665	COG0596	Alpha beta hydrolase
HPY11_RS04685	COG3135	benzoate transporter
HPY11_RS04710	COG3015	lipoprotein NlpE involved in copper resistance
HPY11_RS04715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY11_RS04720	COG2894	cell division
HPY11_RS04725	COG0850	regulation of cytokinetic process
HPY11_RS04730	COG3100	YcgL domain-containing protein
HPY11_RS04735	COG2951	lytic endotransglycosylase activity
HPY11_RS04745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY11_RS04750	COG3005	denitrification pathway
HPY11_RS04755	COG0243	molybdopterin cofactor binding
HPY11_RS04770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_RS04785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY11_RS04820	COG4589	Belongs to the CDS family
HPY11_RS04830	COG3300	MHYT domain
HPY11_RS04830	COG5001	Diguanylate cyclase
HPY11_RS04840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY11_RS04845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY11_RS04850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY11_RS04855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY11_RS04865	COG4191	Histidine kinase
HPY11_RS04875	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY11_RS04885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY11_RS04890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY11_RS04895	COG0776	regulation of translation
HPY11_RS04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY11_RS04905	COG1555	photosystem II stabilization
HPY11_RS04910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY11_RS04915	COG0539	negative regulation of cytoplasmic translation
HPY11_RS04920	COG0776	regulation of translation
HPY11_RS04925	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY11_RS04930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY11_RS04950	COG0583	DNA-binding transcription factor activity
HPY11_RS04960	COG0686	Belongs to the AlaDH PNT family
HPY11_RS04970	COG1674	ftsk spoiiie
HPY11_RS04975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY11_RS04980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY11_RS04985	COG2186	Transcriptional regulator
HPY11_RS05000	COG0537	adenosine 5'-monophosphoramidase activity
HPY11_RS05025	COG3150	esterase
HPY11_RS05030	COG1252	NADH dehydrogenase
HPY11_RS05055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY11_RS05065	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY11_RS05070	COG1136	(ABC) transporter
HPY11_RS05075	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY11_RS05085	COG0658	competence protein
HPY11_RS05085	COG2333	competence protein COMEC
HPY11_RS05090	COG1132	(ABC) transporter
HPY11_RS05095	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY11_RS05100	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY11_RS05105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY11_RS05110	COG2719	SpoVR family
HPY11_RS05115	COG2718	Belongs to the UPF0229 family
HPY11_RS05120	COG2766	serine protein kinase
HPY11_RS05125	COG3013	Belongs to the UPF0304 family
HPY11_RS05135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY11_RS05140	COG0840	transmembrane signaling receptor activity
HPY11_RS05150	COG1882	Formate acetyltransferase
HPY11_RS05175	COG4160	amino acid transport
HPY11_RS05180	COG0708	Exodeoxyribonuclease III
HPY11_RS05190	COG3923	Primosomal replication protein n
HPY11_RS05195	COG0730	response to heat
HPY11_RS05200	COG1199	ATP-dependent helicase activity
HPY11_RS05210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY11_RS05215	COG3012	SEC-C Motif Domain Protein
HPY11_RS05220	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY11_RS05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY11_RS05230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY11_RS05235	COG0215	cysteine-tRNA ligase activity
HPY11_RS05240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY11_RS05245	COG0632	four-way junction helicase activity
HPY11_RS05255	COG1271	oxidase subunit
HPY11_RS05260	COG1294	oxidase, subunit
HPY11_RS05265	COG4890	Cyd operon protein YbgT
HPY11_RS05270	COG3790	cyd operon protein YbgE
HPY11_RS05275	COG0824	Thioesterase
HPY11_RS05280	COG0811	peptide transport
HPY11_RS05295	COG0823	Involved in the tonB-independent uptake of proteins
HPY11_RS05300	COG2885	chlorophyll binding
HPY11_RS05310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY11_RS05320	COG5002	protein histidine kinase activity
HPY11_RS05320	COG0784	Response regulator, receiver
HPY11_RS05330	COG1482	cell wall glycoprotein biosynthetic process
HPY11_RS05335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_RS05335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_RS05335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_RS05340	COG2207	Transcriptional regulator
HPY11_RS05350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_RS05355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_RS05360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_RS05370	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_RS05375	COG3284	Transcriptional regulator
HPY11_RS05380	COG4628	conserved protein (DUF2132)
HPY11_RS05390	COG0415	Belongs to the DNA photolyase family
HPY11_RS05425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_RS05435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY11_RS05435	COG3008	intermembrane lipid transfer
HPY11_RS05440	COG2995	paraquat-inducible protein a
HPY11_RS05445	COG0668	transmembrane transport
HPY11_RS05465	COG1309	transcriptional regulator
HPY11_RS05470	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_RS05490	COG1960	acyl-CoA dehydrogenase activity
HPY11_RS05495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY11_RS05500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY11_RS05510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY11_RS05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY11_RS05530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY11_RS05535	COG0297	glycogen (starch) synthase activity
HPY11_RS05555	COG3070	regulator of competence-specific genes
HPY11_RS05560	COG1609	Transcriptional regulator
HPY11_RS05570	COG0745	RESPONSE REGULATOR receiver
HPY11_RS05575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY11_RS05580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY11_RS05585	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY11_RS05590	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY11_RS05605	COG1280	lysine exporter protein (LysE YggA)
HPY11_RS05610	COG1032	radical SAM domain protein
HPY11_RS05615	COG5001	Diguanylate cyclase
HPY11_RS05620	COG0612	Peptidase, M16
HPY11_RS05635	COG0583	DNA-binding transcription factor activity
HPY11_RS05640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY11_RS05650	COG2350	Protein conserved in bacteria
HPY11_RS05655	COG1607	acyl-coa hydrolase
HPY11_RS05670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY11_RS05675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY11_RS05685	COG2116	formate transmembrane transporter activity
HPY11_RS05690	COG4459	periplasmic nitrate reductase
HPY11_RS05695	COG3005	denitrification pathway
HPY11_RS05700	COG0243	molybdopterin cofactor binding
HPY11_RS05720	COG1227	inorganic diphosphatase activity
HPY11_RS05740	COG4172	Belongs to the ABC transporter superfamily
HPY11_RS05755	COG4168	peptide transport system, permease
HPY11_RS05765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY11_RS05770	COG1842	Phage shock protein A
HPY11_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_RS05800	COG2818	Glycosylase
HPY11_RS05805	COG0626	cystathionine gamma-synthase activity
HPY11_RS05815	COG0733	neurotransmitter:sodium symporter activity
HPY11_RS05840	COG0564	pseudouridine synthase activity
HPY11_RS05845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY11_RS05850	COG4136	ATPase activity
HPY11_RS05855	COG4135	transport system, permease component
HPY11_RS05860	COG4134	Bacterial extracellular solute-binding protein
HPY11_RS05870	COG3313	Fe-S protein
HPY11_RS05880	COG0814	amino acid
HPY11_RS05890	COG2239	Acts as a magnesium transporter
HPY11_RS05895	COG0784	Response regulator, receiver
HPY11_RS05895	COG2205	protein histidine kinase activity
HPY11_RS05910	COG4934	collagen metabolic process
HPY11_RS05945	COG0840	transmembrane signaling receptor activity
HPY11_RS05955	COG5001	Diguanylate cyclase
HPY11_RS05955	COG4251	negative regulation of phosphorylation
HPY11_RS05955	COG3706	GGDEF domain
HPY11_RS05955	COG2203	Gaf domain
HPY11_RS05960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY11_RS05980	COG1061	Type III restriction enzyme res subunit
HPY11_RS05985	COG1187	pseudouridine synthase activity
HPY11_RS05990	COG2814	Major facilitator Superfamily
HPY11_RS06000	COG0702	epimerase
HPY11_RS06005	COG0534	Mate efflux family protein
HPY11_RS06010	COG4181	ATPase activity
HPY11_RS06025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY11_RS06035	COG1748	Saccharopine dehydrogenase
HPY11_RS06050	COG1538	Outer membrane efflux protein
HPY11_RS06070	COG0583	DNA-binding transcription factor activity
HPY11_RS06080	COG1451	nucleotide metabolic process
HPY11_RS06095	COG3063	Type IV pilus biogenesis stability protein PilW
HPY11_RS06100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY11_RS06120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_RS06135	COG3290	protein histidine kinase activity
HPY11_RS06140	COG4565	transcriptional regulatory protein
HPY11_RS06150	COG0784	Response regulator, receiver
HPY11_RS06150	COG0835	chemotaxis
HPY11_RS06200	COG1085	galactose-1-phosphate uridylyltransferase
HPY11_RS06205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY11_RS06210	COG2017	converts alpha-aldose to the beta-anomer
HPY11_RS06225	COG3527	Alpha-acetolactate decarboxylase
HPY11_RS06235	COG3064	Membrane
HPY11_RS06245	COG0753	catalase activity
HPY11_RS06265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY11_RS06275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY11_RS06315	COG1271	oxidase subunit
HPY11_RS06320	COG1294	oxidase, subunit
HPY11_RS06325	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY11_RS06325	COG1136	(ABC) transporter
HPY11_RS06330	COG0577	efflux transmembrane transporter activity
HPY11_RS06330	COG1136	(ABC) transporter
HPY11_RS06335	COG0577	efflux transmembrane transporter activity
HPY11_RS06335	COG1136	(ABC) transporter
HPY11_RS06355	COG0583	DNA-binding transcription factor activity
HPY11_RS06385	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HPY11_RS06425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY11_RS06440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY11_RS06450	COG2723	6-phospho-beta-galactosidase activity
HPY11_RS06455	COG1609	Transcriptional regulator
HPY11_RS06460	COG0251	oxidation-reduction process
HPY11_RS06465	COG2731	YhcH YjgK YiaL family protein
HPY11_RS06470	COG0584	glycerophosphoryl diester phosphodiesterase
HPY11_RS06475	COG1349	DNA-binding transcription factor activity
HPY11_RS06480	COG3842	ATPase activity
HPY11_RS06485	COG0395	ABC-type sugar transport system, permease component
HPY11_RS06490	COG1175	transmembrane transport
HPY11_RS06505	COG0811	peptide transport
HPY11_RS06510	COG0811	peptide transport
HPY11_RS06515	COG0848	biopolymer transport protein
HPY11_RS06520	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY11_RS06530	COG1793	dna ligase
HPY11_RS06540	COG0534	Mate efflux family protein
HPY11_RS06550	COG3001	Fructosamine kinase
HPY11_RS06560	COG0791	NLP P60 protein
HPY11_RS06565	COG0840	transmembrane signaling receptor activity
HPY11_RS06580	COG1940	carbohydrate kinase activity
HPY11_RS06590	COG0303	'Molybdopterin
HPY11_RS06595	COG0746	molybdenum cofactor guanylyltransferase activity
HPY11_RS06600	COG3842	ATPase activity
HPY11_RS06605	COG4662	Binding-protein-dependent transport system inner membrane component
HPY11_RS06615	COG2204	response regulator
HPY11_RS06620	COG3852	Histidine kinase
HPY11_RS06625	COG0488	(ABC) transporter
HPY11_RS06635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY11_RS06665	COG0243	molybdopterin cofactor binding
HPY11_RS06665	COG3383	formate dehydrogenase (NAD+) activity
HPY11_RS06670	COG0437	4 iron, 4 sulfur cluster binding
HPY11_RS06685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY11_RS06690	COG1666	GTP binding
HPY11_RS06695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY11_RS06710	COG2996	Protein conserved in bacteria
HPY11_RS06720	COG3008	intermembrane lipid transfer
HPY11_RS06725	COG2995	paraquat-inducible protein a
HPY11_RS06730	COG1132	(ABC) transporter
HPY11_RS06735	COG1956	GAF domain-containing protein
HPY11_RS06740	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY11_RS06755	COG0308	aminopeptidase N
HPY11_RS06770	COG0167	dihydroorotate dehydrogenase activity
HPY11_RS06780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY11_RS06780	COG0116	Belongs to the methyltransferase superfamily
HPY11_RS06805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY11_RS06810	COG1067	ATP-dependent peptidase activity
HPY11_RS06815	COG3120	sequence-specific DNA binding
HPY11_RS06890	COG2994	toxin metabolic process
HPY11_RS06915	COG2205	protein histidine kinase activity
HPY11_RS06915	COG0784	Response regulator, receiver
HPY11_RS06930	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY11_RS06945	COG2010	Cytochrome c
HPY11_RS06955	COG2217	Heavy metal translocating P-type atpase
HPY11_RS06970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY11_RS06975	COG0589	response to stress
HPY11_RS06980	COG0037	tRNA processing
HPY11_RS07000	COG3842	ATPase activity
HPY11_RS07010	COG1177	transmembrane transport
HPY11_RS07020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY11_RS07035	COG1115	amino acid carrier protein
HPY11_RS07040	COG1280	lysine exporter protein (LysE YggA)
HPY11_RS07070	COG3501	Rhs element vgr protein
HPY11_RS07080	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY11_RS07085	COG1960	acyl-CoA dehydrogenase activity
HPY11_RS07095	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_RS07100	COG3384	dioxygenase
HPY11_RS07135	COG3971	2-oxopent-4-enoate hydratase activity
HPY11_RS07155	COG1846	Transcriptional regulator
HPY11_RS07215	COG0513	Belongs to the DEAD box helicase family
HPY11_RS07220	COG2076	Multidrug Resistance protein
HPY11_RS07225	COG0477	Major facilitator Superfamily
HPY11_RS07230	COG0583	DNA-binding transcription factor activity
HPY11_RS07240	COG0402	S-adenosylhomocysteine deaminase activity
HPY11_RS07245	COG0095	Lipoate-protein ligase
HPY11_RS07250	COG0443	Heat shock 70 kDa protein
HPY11_RS07260	COG1643	Atp-dependent helicase
HPY11_RS07290	COG0443	Heat shock 70 kDa protein
HPY11_RS07295	COG0443	Heat shock 70 kDa protein
HPY11_RS07300	COG3706	GGDEF domain
HPY11_RS07330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY11_RS07335	COG0602	queuosine metabolic process
HPY11_RS07340	COG0561	phosphatase activity
HPY11_RS07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_RS07355	COG4597	amino acid ABC transporter
HPY11_RS07360	COG0765	amino acid transport
HPY11_RS07365	COG1126	abc transporter atp-binding protein
HPY11_RS07370	COG0670	Belongs to the BI1 family
HPY11_RS07375	COG2920	part of a sulfur-relay system
HPY11_RS07380	COG1254	Belongs to the acylphosphatase family
HPY11_RS07390	COG3706	GGDEF domain
HPY11_RS07400	COG3437	response regulator, receiver
HPY11_RS07400	COG4999	Histidine kinase
HPY11_RS07400	COG3850	Histidine kinase
HPY11_RS07400	COG2205	protein histidine kinase activity
HPY11_RS07405	COG3437	response regulator, receiver
HPY11_RS07410	COG0625	glutathione transferase activity
HPY11_RS07420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY11_RS07430	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY11_RS07460	COG0372	Belongs to the citrate synthase family
HPY11_RS07465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY11_RS07490	COG0583	DNA-binding transcription factor activity
HPY11_RS07495	COG4771	TonB-dependent receptor
HPY11_RS07520	COG1566	PFAM secretion protein HlyD family protein
HPY11_RS07540	COG1129	ABC transporter
HPY11_RS07565	COG0745	RESPONSE REGULATOR receiver
HPY11_RS07570	COG5002	protein histidine kinase activity
HPY11_RS07575	COG3713	MltA-interacting MipA family protein
HPY11_RS07580	COG2990	Protein conserved in bacteria
HPY11_RS07590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_RS07590	COG4191	Histidine kinase
HPY11_RS07595	COG0471	metal ion transport
HPY11_RS07605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY11_RS07620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_RS07630	COG3768	UPF0283 membrane protein
HPY11_RS07635	COG3106	COG3106 Predicted ATPase
HPY11_RS07650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY11_RS07655	COG0494	nUDIX hydrolase
HPY11_RS07660	COG0814	amino acid
HPY11_RS07665	COG1760	l-serine dehydratase
HPY11_RS07670	COG0720	synthase
HPY11_RS07675	COG0840	transmembrane signaling receptor activity
HPY11_RS07680	COG0017	Asparaginyl-tRNA synthetase
HPY11_RS07685	COG0351	phosphomethylpyrimidine kinase
HPY11_RS07690	COG2770	Histidine kinase
HPY11_RS07690	COG3437	response regulator, receiver
HPY11_RS07695	COG1448	Aminotransferase
HPY11_RS07710	COG0840	transmembrane signaling receptor activity
HPY11_RS07715	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY11_RS07720	COG2943	transferase activity, transferring hexosyl groups
HPY11_RS07725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY11_RS07730	COG1846	Transcriptional regulator
HPY11_RS07755	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY11_RS07770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY11_RS07775	COG3108	Peptidase M15
HPY11_RS07805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY11_RS07815	COG2814	Major facilitator Superfamily
HPY11_RS07835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY11_RS07840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY11_RS07845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY11_RS07890	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY11_RS07895	COG4139	cobalamin transport
HPY11_RS07900	COG2988	succinylglutamate desuccinylase activity
HPY11_RS07915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY11_RS07920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY11_RS07925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_RS07935	COG2925	Exonuclease
HPY11_RS07940	COG1380	Effector of murein hydrolase LrgA
HPY11_RS07945	COG1346	cytolysis
HPY11_RS07965	COG0500	methyltransferase
HPY11_RS07975	COG0776	regulation of translation
HPY11_RS07980	COG0072	phenylalanine-tRNA ligase activity
HPY11_RS07980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_RS07985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY11_RS08025	COG0322	excinuclease ABC activity
HPY11_RS08030	COG2197	response regulator
HPY11_RS08035	COG0417	DNA replication proofreading
HPY11_RS08050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY11_RS08055	COG3099	Belongs to the UPF0263 family
HPY11_RS08070	COG1228	amidohydrolase
HPY11_RS08075	COG0010	Belongs to the arginase family
HPY11_RS08080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY11_RS08085	COG2986	histidine ammonia-lyase
HPY11_RS08105	COG0247	lactate metabolic process
HPY11_RS08105	COG0277	FAD linked oxidase domain protein
HPY11_RS08120	COG2885	chlorophyll binding
HPY11_RS08140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY11_RS08150	COG0281	malic enzyme
HPY11_RS08160	COG2949	membrane
HPY11_RS08165	COG3706	GGDEF domain
HPY11_RS08170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY11_RS08180	COG0492	ferredoxin-NADP+ reductase activity
HPY11_RS08185	COG4988	ABC transporter
HPY11_RS08190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY11_RS08195	COG1187	pseudouridine synthase activity
HPY11_RS08200	COG0009	L-threonylcarbamoyladenylate synthase
HPY11_RS08205	COG0613	PHP domain protein
HPY11_RS08215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY11_RS08220	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY11_RS08225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY11_RS08230	COG0134	indole-3-glycerol-phosphate synthase activity
HPY11_RS08230	COG0135	phosphoribosylanthranilate isomerase activity
HPY11_RS08235	COG0133	tryptophan synthase activity
HPY11_RS08240	COG0159	tryptophan synthase activity
HPY11_RS08250	COG1435	thymidine kinase activity
HPY11_RS08255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY11_RS08260	COG1801	Protein of unknown function DUF72
HPY11_RS08265	COG4106	trans-aconitate 2-methyltransferase activity
HPY11_RS08270	COG0500	methyltransferase
HPY11_RS08275	COG4067	protein conserved in archaea
HPY11_RS08275	COG0189	ligase activity
HPY11_RS08290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY11_RS08300	COG3852	Histidine kinase
HPY11_RS08315	COG3070	regulator of competence-specific genes
HPY11_RS08325	COG2431	L-lysine efflux transmembrane transporter activity
HPY11_RS08335	COG0076	glutamate decarboxylase activity
HPY11_RS08340	COG1737	Transcriptional regulator
HPY11_RS08345	COG1454	alcohol dehydrogenase
HPY11_RS08345	COG1012	belongs to the aldehyde dehydrogenase family
HPY11_RS08350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY11_RS08355	COG3273	potassium ion transport
HPY11_RS08355	COG2985	domain, Protein
HPY11_RS08360	COG0542	response to heat
HPY11_RS08365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY11_RS08370	COG1278	Cold shock
HPY11_RS08380	COG1187	pseudouridine synthase activity
HPY11_RS08385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY11_RS08385	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY11_RS08390	COG0107	imidazoleglycerol-phosphate synthase activity
HPY11_RS08395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY11_RS08400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY11_RS08405	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY11_RS08405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY11_RS08410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY11_RS08415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY11_RS08420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY11_RS08425	COG1757	Na H antiporter
HPY11_RS08430	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY11_RS08435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_RS08440	COG0482	sulfurtransferase activity
HPY11_RS08445	COG2915	High frequency lysogenization protein hflD homolog
HPY11_RS08450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY11_RS08460	COG2268	Band 7 protein
HPY11_RS08470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY11_RS08485	COG0300	oxidoreductase activity
HPY11_RS08495	COG0501	Belongs to the peptidase M48B family
HPY11_RS08505	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY11_RS08510	COG2226	methyltransferase
HPY11_RS08515	COG0156	8-amino-7-oxononanoate synthase activity
HPY11_RS08520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY11_RS08525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY11_RS08530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY11_RS08535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY11_RS08540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY11_RS08550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY11_RS08555	COG2203	Gaf domain
HPY11_RS08555	COG2199	diguanylate cyclase activity
HPY11_RS08565	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY11_RS08575	COG4628	conserved protein (DUF2132)
HPY11_RS08580	COG3092	negative regulation of chromosome organization
HPY11_RS08585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY11_RS08590	COG0280	phosphate acetyltransferase
HPY11_RS08590	COG0857	belongs to the CobB CobQ family
HPY11_RS08595	COG0435	Glutathione S-transferase
HPY11_RS08600	COG4608	Belongs to the ABC transporter superfamily
HPY11_RS08605	COG0444	Belongs to the ABC transporter superfamily
HPY11_RS08610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_RS08615	COG0601	transmembrane transport
HPY11_RS08635	COG2204	response regulator
HPY11_RS08640	COG3300	MHYT domain
HPY11_RS08640	COG5001	Diguanylate cyclase
HPY11_RS08645	COG4191	Histidine kinase
HPY11_RS08650	COG5002	protein histidine kinase activity
HPY11_RS08660	COG2201	protein-glutamate methylesterase activity
HPY11_RS08675	COG0009	L-threonylcarbamoyladenylate synthase
HPY11_RS08690	COG1881	PFAM PEBP family protein
HPY11_RS08715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY11_RS08720	COG0640	Transcriptional regulator
HPY11_RS08790	COG0322	excinuclease ABC activity
HPY11_RS08830	COG3706	GGDEF domain
HPY11_RS08850	COG1946	Acyl-CoA thioesterase
HPY11_RS08855	COG1522	sequence-specific DNA binding
HPY11_RS08865	COG0616	signal peptide processing
HPY11_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_RS08875	COG2983	Belongs to the UPF0260 family
HPY11_RS08885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY11_RS08890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY11_RS08900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY11_RS08905	COG2832	Protein of unknown function (DUF454)
HPY11_RS08910	COG0745	RESPONSE REGULATOR receiver
HPY11_RS08915	COG0583	DNA-binding transcription factor activity
HPY11_RS08920	COG0778	Nitroreductase
HPY11_RS08925	COG1024	Enoyl-CoA hydratase
HPY11_RS08925	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY11_RS08930	COG0183	Belongs to the thiolase family
HPY11_RS08945	COG2067	long-chain fatty acid transport protein
HPY11_RS08955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY11_RS08960	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY11_RS08965	COG2982	Protein involved in outer membrane biogenesis
HPY11_RS08970	COG0572	uridine kinase
HPY11_RS08975	COG0489	protein tyrosine kinase activity
HPY11_RS08980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_RS08980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY11_RS08990	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY11_RS09000	COG0517	IMP dehydrogenase activity
HPY11_RS09000	COG0617	tRNA 3'-terminal CCA addition
HPY11_RS09000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY11_RS09005	COG2199	diguanylate cyclase activity
HPY11_RS09010	COG0314	molybdopterin synthase activity
HPY11_RS09015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY11_RS09020	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY11_RS09025	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY11_RS09030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY11_RS09035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY11_RS09040	COG2198	Histidine kinase
HPY11_RS09045	COG2204	response regulator
HPY11_RS09050	COG0556	nucleotide-excision repair
HPY11_RS09060	COG4657	Part of a membrane complex involved in electron transport
HPY11_RS09065	COG2878	Part of a membrane complex involved in electron transport
HPY11_RS09070	COG4656	Part of a membrane complex involved in electron transport
HPY11_RS09085	COG4660	Part of a membrane complex involved in electron transport
HPY11_RS09090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY11_RS09095	COG0346	lactoylglutathione lyase activity
HPY11_RS09110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY11_RS09115	COG2056	Na+-H+ antiporter family
HPY11_RS09120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY11_RS09125	COG1286	toxin biosynthetic process
HPY11_RS09130	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY11_RS09135	COG0285	dihydrofolate synthase activity
HPY11_RS09140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY11_RS09145	COG0101	tRNA pseudouridine synthase activity
HPY11_RS09160	COG1263	PTS System
HPY11_RS09160	COG2190	(PTS) system
HPY11_RS09160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_RS09165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY11_RS09170	COG1846	Transcriptional regulator
HPY11_RS09170	COG1940	carbohydrate kinase activity
HPY11_RS09175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY11_RS09175	COG4651	solute:proton antiporter activity
HPY11_RS09180	COG0367	asparagine synthase
HPY11_RS09195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY11_RS09200	COG0563	adenylate kinase activity
HPY11_RS09205	COG0326	Molecular chaperone. Has ATPase activity
HPY11_RS09210	COG3710	Transcriptional regulator
HPY11_RS09225	COG0622	Phosphoesterase
HPY11_RS09230	COG1090	epimerase
HPY11_RS09235	COG0300	oxidoreductase activity
HPY11_RS09240	COG3118	belongs to the thioredoxin family
HPY11_RS09245	COG0330	HflC and HflK could
HPY11_RS09250	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY11_RS09255	COG0789	Transcriptional regulator
HPY11_RS09270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY11_RS09275	COG3115	cell septum assembly
HPY11_RS09280	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY11_RS09290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_RS09300	COG2190	(PTS) system
HPY11_RS09305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY11_RS09310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY11_RS09315	COG1702	phosphate starvation-inducible protein PhoH
HPY11_RS09325	COG4535	Mg2 and Co2 transporter CorC
HPY11_RS09330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY11_RS09335	COG2888	peptidyl-tyrosine sulfation
HPY11_RS09340	COG0495	leucyl-tRNA aminoacylation
HPY11_RS09345	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY11_RS09350	COG1466	dna polymerase III delta subunit
HPY11_RS09355	COG0799	negative regulation of ribosome biogenesis
HPY11_RS09360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY11_RS09365	COG0768	penicillin binding
HPY11_RS09370	COG0772	Belongs to the SEDS family
HPY11_RS09375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY11_RS09380	COG1686	Belongs to the peptidase S11 family
HPY11_RS09385	COG2921	Belongs to the UPF0250 family
HPY11_RS09390	COG0321	lipoyl(octanoyl) transferase activity
HPY11_RS09395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY11_RS09405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY11_RS09430	COG1596	polysaccharide export
HPY11_RS09440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY11_RS09470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY11_RS09480	COG0438	transferase activity, transferring glycosyl groups
HPY11_RS09490	COG1045	serine acetyltransferase
HPY11_RS09510	COG0110	maltose O-acetyltransferase activity
HPY11_RS09515	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY11_RS09520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY11_RS09525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY11_RS09530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY11_RS09560	COG0366	Alpha amylase catalytic
HPY11_RS09565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_RS09565	COG1263	PTS System
HPY11_RS09570	COG1609	Transcriptional regulator
HPY11_RS09575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY11_RS09580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY11_RS09585	COG2011	ABC-type metal ion transport system permease component
HPY11_RS09590	COG1464	Belongs to the NlpA lipoprotein family
HPY11_RS09595	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY11_RS09605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY11_RS09605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY11_RS09615	COG3706	GGDEF domain
HPY11_RS09620	COG1611	Belongs to the LOG family
HPY11_RS09625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY11_RS09630	COG2363	Small membrane protein
HPY11_RS09635	COG0583	DNA-binding transcription factor activity
HPY11_RS09640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY11_RS09640	COG0301	tRNA thio-modification
HPY11_RS09650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY11_RS09655	COG1722	exodeoxyribonuclease VII activity
HPY11_RS09660	COG0142	geranyltranstransferase activity
HPY11_RS09665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY11_RS09670	COG0564	pseudouridine synthase activity
HPY11_RS09675	COG3098	single-species biofilm formation
HPY11_RS09690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_RS09700	COG1671	Belongs to the UPF0178 family
HPY11_RS09705	COG3385	transposase activity
HPY11_RS09710	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY11_RS09715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY11_RS09720	COG0254	rRNA binding
HPY11_RS09725	COG1720	tRNA m6t6A37 methyltransferase activity
HPY11_RS09730	COG0442	prolyl-tRNA aminoacylation
HPY11_RS09750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY11_RS09750	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY11_RS09760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY11_RS09770	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY11_RS09800	COG0484	heat shock protein binding
HPY11_RS09805	COG0443	Heat shock 70 kDa protein
HPY11_RS09810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY11_RS09815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY11_RS09820	COG0497	DNA recombination
HPY11_RS09825	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_RS09830	COG2914	Belongs to the UPF0125 (RnfH) family
HPY11_RS09835	COG2867	negative regulation of translational initiation
HPY11_RS09840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY11_RS09860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPY11_RS09870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPY11_RS09885	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY11_RS09890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY11_RS09895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY11_RS09930	COG1115	amino acid carrier protein
HPY11_RS09935	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY11_RS09940	COG0583	DNA-binding transcription factor activity
HPY11_RS09950	COG1120	ATPase activity
HPY11_RS09955	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_RS09960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_RS09965	COG4592	Periplasmic binding protein
HPY11_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_RS09980	COG1169	isochorismate synthase
HPY11_RS09985	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY11_RS09990	COG3433	isochorismatase activity
HPY11_RS09990	COG1535	isochorismatase
HPY11_RS09995	COG1584	GPR1 FUN34 yaaH family protein
HPY11_RS10005	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY11_RS10040	COG0464	growth
HPY11_RS10105	COG0582	viral genome integration into host DNA
HPY11_RS10110	COG0519	Catalyzes the synthesis of GMP from XMP
HPY11_RS10110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY11_RS10115	COG0517	IMP dehydrogenase activity
HPY11_RS10115	COG0516	GMP reductase activity
HPY11_RS10120	COG1570	exodeoxyribonuclease VII activity
HPY11_RS10135	COG1160	GTP binding
HPY11_RS10140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_RS10145	COG2976	Protein conserved in bacteria
HPY11_RS10150	COG0124	histidyl-tRNA synthetase
HPY11_RS10155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY11_RS10170	COG0105	UTP biosynthetic process
HPY11_RS10175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY11_RS10180	COG2975	iron-sulfur cluster assembly
HPY11_RS10185	COG0633	Ferredoxin
HPY11_RS10205	COG0822	iron-sulfur transferase activity
HPY11_RS10210	COG1104	cysteine desulfurase activity
HPY11_RS10215	COG1959	2 iron, 2 sulfur cluster binding
HPY11_RS10225	COG0483	inositol monophosphate 1-phosphatase activity
HPY11_RS10230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_RS10235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_RS10240	COG1862	Preprotein translocase
HPY11_RS10250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY11_RS10255	COG0517	IMP dehydrogenase activity
HPY11_RS10265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY11_RS10270	COG0583	DNA-binding transcription factor activity
HPY11_RS10275	COG0450	alkyl hydroperoxide reductase
HPY11_RS10280	COG3142	Participates in the control of copper homeostasis
HPY11_RS10295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY11_RS10300	COG0581	inorganic phosphate transmembrane transporter activity
HPY11_RS10310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY11_RS10315	COG0248	Ppx GppA phosphatase
HPY11_RS10325	COG5002	protein histidine kinase activity
HPY11_RS10330	COG0745	RESPONSE REGULATOR receiver
HPY11_RS10345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY11_RS10390	COG0542	response to heat
HPY11_RS10400	COG0564	pseudouridine synthase activity
HPY11_RS10405	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_RS10410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY11_RS10415	COG1605	Chorismate mutase
HPY11_RS10415	COG0077	Prephenate dehydratase
HPY11_RS10420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY11_RS10425	COG5001	Diguanylate cyclase
HPY11_RS10435	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY11_RS10445	COG0488	(ABC) transporter
HPY11_RS10455	COG0287	Prephenate dehydrogenase
HPY11_RS10455	COG1605	Chorismate mutase
HPY11_RS10460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY11_RS10465	COG3275	phosphorelay sensor kinase activity
HPY11_RS10470	COG3279	Response regulator of the LytR AlgR family
HPY11_RS10480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY11_RS10485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY11_RS10500	COG1966	Carbon starvation protein
HPY11_RS10505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY11_RS10510	COG1047	Peptidyl-prolyl cis-trans
HPY11_RS10515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY11_RS10525	COG0196	riboflavin kinase activity
HPY11_RS10530	COG0728	peptidoglycan biosynthetic process
HPY11_RS10535	COG0268	Binds directly to 16S ribosomal RNA
HPY11_RS10540	COG0640	Transcriptional regulator
HPY11_RS10545	COG0583	DNA-binding transcription factor activity
HPY11_RS10550	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY11_RS10560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY11_RS10565	COG0730	response to heat
HPY11_RS10570	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY11_RS10575	COG0494	nUDIX hydrolase
HPY11_RS10585	COG0667	Aldo Keto reductase
HPY11_RS10595	COG2204	response regulator
HPY11_RS10600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY11_RS10620	COG0513	Belongs to the DEAD box helicase family
HPY11_RS10645	COG3153	acetyltransferase
HPY11_RS10650	COG3154	lipid carrier protein
HPY11_RS10660	COG0826	peptidase U32
HPY11_RS10665	COG0826	peptidase U32
HPY11_RS10680	COG3385	transposase activity
HPY11_RS10695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY11_RS10705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY11_RS10710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY11_RS10715	COG0195	Participates in both transcription termination and antitermination
HPY11_RS10720	COG0779	Required for maturation of 30S ribosomal subunits
HPY11_RS10735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY11_RS10745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY11_RS10750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY11_RS10755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY11_RS10760	COG1534	Rna-binding protein
HPY11_RS10765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY11_RS10770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY11_RS10775	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY11_RS10780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY11_RS10785	COG0739	heme binding
HPY11_RS10800	COG0316	Belongs to the HesB IscA family
HPY11_RS10810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY11_RS10815	COG0628	permease
HPY11_RS10820	COG2813	Specifically methylates the guanine in position
HPY11_RS10830	COG0747	negative chemotaxis
HPY11_RS10840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_RS10845	COG0444	Belongs to the ABC transporter superfamily
HPY11_RS10850	COG4608	Belongs to the ABC transporter superfamily
HPY11_RS10860	COG2971	BadF BadG BcrA BcrD
HPY11_RS10880	COG3842	ATPase activity
HPY11_RS10890	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY11_RS10895	COG0004	ammonium transporteR
HPY11_RS10900	COG0347	Belongs to the P(II) protein family
HPY11_RS10905	COG3112	Uncharacterised protein family (UPF0231)
HPY11_RS10910	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY11_RS10915	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY11_RS10920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY11_RS10925	COG1643	Atp-dependent helicase
HPY11_RS10935	COG1489	DNA binding
HPY11_RS10945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY11_RS10955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY11_RS10960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY11_RS10965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY11_RS10970	COG0842	Transport permease protein
HPY11_RS10975	COG1131	(ABC) transporter
HPY11_RS10980	COG0659	secondary active sulfate transmembrane transporter activity
HPY11_RS10985	COG0288	reversible hydration of carbon dioxide
HPY11_RS11000	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY11_RS11005	COG3107	peptidoglycan biosynthetic process
HPY11_RS11010	COG0792	nuclease activity
HPY11_RS11015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY11_RS11020	COG2823	Periplasmic or secreted lipoprotein
HPY11_RS11025	COG2969	positive regulation of protein catabolic process
HPY11_RS11030	COG0625	glutathione transferase activity
HPY11_RS11035	COG2857	Cytochrome c1
HPY11_RS11040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY11_RS11045	COG0723	plastoquinol--plastocyanin reductase activity
HPY11_RS11050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY11_RS11055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY11_RS11060	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY11_RS11070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY11_RS11075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY11_RS11080	COG0335	large ribosomal subunit rRNA binding
HPY11_RS11085	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY11_RS11090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY11_RS11095	COG0228	four-way junction DNA binding
HPY11_RS11100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY11_RS11105	COG4137	Cytochrome C assembly protein
HPY11_RS11110	COG4536	flavin adenine dinucleotide binding
HPY11_RS11115	COG1854	S-ribosylhomocysteine lyase activity
HPY11_RS11120	COG2918	glutathione biosynthetic process
HPY11_RS11125	COG0612	Peptidase, M16
HPY11_RS11130	COG1238	metal cluster binding
HPY11_RS11140	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY11_RS11145	COG0511	ligase activity, forming carbon-carbon bonds
HPY11_RS11145	COG5016	pyruvate
HPY11_RS11150	COG3630	sodium ion export across plasma membrane
HPY11_RS11195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY11_RS11200	COG0527	aspartate kinase activity
HPY11_RS11205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY11_RS11210	COG2137	regulation of response to DNA damage stimulus
HPY11_RS11215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY11_RS11225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY11_RS11230	COG4208	sulfate ABC transporter
HPY11_RS11250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY11_RS11255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY11_RS11265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY11_RS11270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY11_RS11275	COG0585	pseudouridine synthase activity
HPY11_RS11280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY11_RS11285	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY11_RS11290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY11_RS11295	COG1968	undecaprenyl-diphosphatase activity
HPY11_RS11300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY11_RS11305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY11_RS11310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY11_RS11320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY11_RS11325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY11_RS11330	COG1610	YqeY-like protein
HPY11_RS11355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY11_RS11360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY11_RS11365	COG1349	DNA-binding transcription factor activity
HPY11_RS11385	COG1279	arginine transmembrane transporter activity
HPY11_RS11390	COG0668	transmembrane transport
HPY11_RS11395	COG0191	fructose-bisphosphate aldolase activity
HPY11_RS11400	COG0126	phosphoglycerate kinase activity
HPY11_RS11405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY11_RS11410	COG4771	TonB-dependent receptor
HPY11_RS11415	COG0583	DNA-binding transcription factor activity
HPY11_RS11420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY11_RS11425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY11_RS11435	COG2356	endonuclease I
HPY11_RS11440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY11_RS11445	COG0189	ligase activity
HPY11_RS11450	COG1678	Uncharacterized ACR, COG1678
HPY11_RS11455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY11_RS11460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY11_RS11480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY11_RS11485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY11_RS11490	COG0762	integral membrane protein
HPY11_RS11505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY11_RS11510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY11_RS11515	COG2066	Belongs to the glutaminase family
HPY11_RS11520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY11_RS11525	COG1194	a g-specific adenine glycosylase
HPY11_RS11530	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY11_RS11535	COG0741	lytic transglycosylase activity
HPY11_RS11590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY11_RS11595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY11_RS11600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY11_RS11605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY11_RS11610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY11_RS11615	COG2967	ApaG domain
HPY11_RS11620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY11_RS11630	COG3610	response to peptide
HPY11_RS11635	COG2966	Psort location CytoplasmicMembrane, score
HPY11_RS11640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY11_RS11645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY11_RS11650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY11_RS11655	COG0142	geranyltranstransferase activity
HPY11_RS11660	COG0531	amino acid
HPY11_RS11665	COG0039	L-malate dehydrogenase activity
HPY11_RS11670	COG1438	arginine binding
HPY11_RS11675	COG2358	TRAP transporter, solute receptor (TAXI family
HPY11_RS11685	COG0589	response to stress
HPY11_RS11705	COG2235	arginine
HPY11_RS11710	COG0312	modulator of DNA gyrase
HPY11_RS11715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY11_RS11720	COG3164	Protein of unknown function
HPY11_RS11725	COG1530	ribonuclease E activity
HPY11_RS11730	COG0424	maF-like protein
HPY11_RS11735	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY11_RS11740	COG1792	Involved in formation and maintenance of cell shape
HPY11_RS11745	COG1077	Cell shape determining protein MreB Mrl
HPY11_RS11790	COG1459	type II secretion system
HPY11_RS11795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY11_RS11805	COG3409	Peptidoglycan-binding domain 1 protein
HPY11_RS11805	COG3267	Type II secretory pathway component ExeA
HPY11_RS11860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY11_RS11865	COG0527	aspartate kinase activity
HPY11_RS11870	COG0646	methionine synthase
HPY11_RS11870	COG1410	methionine synthase
HPY11_RS11945	COG0175	sulfate reduction
HPY11_RS11955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY11_RS11980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY11_RS11985	COG0735	belongs to the Fur family
HPY11_RS12000	COG0166	Belongs to the GPI family
HPY11_RS12005	COG0432	Pfam Uncharacterised protein family UPF0047
HPY11_RS12010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY11_RS12025	COG0359	binds to the 23S rRNA
HPY11_RS12030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY11_RS12035	COG2965	DNA replication, synthesis of RNA primer
HPY11_RS12040	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY11_RS12050	COG2906	2 iron, 2 sulfur cluster binding
HPY11_RS12055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY11_RS12060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY11_RS12065	COG0049	tRNA binding
HPY11_RS12080	COG2923	Belongs to the DsrF TusC family
HPY11_RS12085	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY11_RS12090	COG2964	Protein conserved in bacteria
HPY11_RS12095	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY11_RS12105	COG2900	Belongs to the SlyX family
HPY11_RS12110	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY11_RS12115	COG0330	HflC and HflK could
HPY11_RS12120	COG0330	HflC and HflK could
HPY11_RS12125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY11_RS12130	COG1923	regulation of RNA biosynthetic process
HPY11_RS12135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY11_RS12140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY11_RS12150	COG0802	atpase or kinase
HPY11_RS12155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY11_RS12205	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY11_RS12210	COG1162	GTPase activity
HPY11_RS12215	COG0688	phosphatidylethanolamine metabolic process
HPY11_RS12220	COG0471	metal ion transport
HPY11_RS12230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY11_RS12235	COG4942	peptidase
HPY11_RS12250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY11_RS12255	COG2816	NAD+ diphosphatase activity
HPY11_RS12260	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY11_RS12265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY11_RS12270	COG0085	RNA polymerase activity
HPY11_RS12275	COG0222	ribosome binding
HPY11_RS12280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY11_RS12290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY11_RS12295	COG0250	Participates in transcription elongation, termination and antitermination
HPY11_RS12300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY11_RS12305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY11_RS12330	COG1072	(Pantothenic acid kinase))
HPY11_RS12340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY11_RS12350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY11_RS12395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY11_RS12410	COG3118	belongs to the thioredoxin family
HPY11_RS12415	COG0513	Belongs to the DEAD box helicase family
HPY11_RS12420	COG0248	Ppx GppA phosphatase
HPY11_RS12425	COG0784	Response regulator, receiver
HPY11_RS12425	COG2205	protein histidine kinase activity
HPY11_RS12430	COG2814	Major facilitator Superfamily
HPY11_RS12445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY11_RS12450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY11_RS12455	COG0511	ligase activity, forming carbon-carbon bonds
HPY11_RS12460	COG0439	Biotin carboxylase
HPY11_RS12465	COG2264	protein methyltransferase activity
HPY11_RS12470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY11_RS12475	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY11_RS12485	COG1609	Transcriptional regulator
HPY11_RS12495	COG0129	dihydroxy-acid dehydratase activity
HPY11_RS12500	COG3265	gluconokinase activity
HPY11_RS12510	COG0800	Aldolase
HPY11_RS12530	COG0840	transmembrane signaling receptor activity
HPY11_RS12535	COG1982	Orn Lys Arg decarboxylase major
HPY11_RS12540	COG0531	amino acid
HPY11_RS12545	COG3710	Transcriptional regulator
HPY11_RS12550	COG0789	Transcriptional regulator
HPY11_RS12565	COG0151	Belongs to the GarS family
HPY11_RS12575	COG0776	regulation of translation
HPY11_RS12580	COG1253	flavin adenine dinucleotide binding
HPY11_RS12585	COG3068	Protein conserved in bacteria
HPY11_RS12595	COG1573	uracil-dna glycosylase
HPY11_RS12600	COG0668	transmembrane transport
HPY11_RS12605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY11_RS12615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPY11_RS12635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY11_RS12640	COG1215	transferase activity, transferring glycosyl groups
HPY11_RS12655	COG1215	transferase activity, transferring glycosyl groups
HPY11_RS12675	COG1596	polysaccharide export
HPY11_RS12695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY11_RS12725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY11_RS12745	COG2226	methyltransferase
HPY11_RS12780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY11_RS12800	COG0859	PFAM glycosyl transferase family 9
HPY11_RS12810	COG1519	Transferase
HPY11_RS12815	COG0456	acetyltransferase
HPY11_RS12820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY11_RS12835	COG3642	lipopolysaccharide core region biosynthetic process
HPY11_RS12840	COG0859	PFAM glycosyl transferase family 9
HPY11_RS12845	COG0463	Glycosyl transferase, family 2
HPY11_RS12850	COG0859	PFAM glycosyl transferase family 9
HPY11_RS12855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY11_RS12860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY11_RS12870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY11_RS12875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY11_RS12880	COG2003	Belongs to the UPF0758 family
HPY11_RS12890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY11_RS12900	COG1309	transcriptional regulator
HPY11_RS12905	COG1560	Kdo2-lipid A biosynthetic process
HPY11_RS12910	COG1560	Kdo2-lipid A biosynthetic process
HPY11_RS12915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY11_RS12920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY11_RS12925	COG1561	YicC-like family, N-terminal region
HPY11_RS12980	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPY11_RS13030	COG2862	Uncharacterized protein family, UPF0114
HPY11_RS13035	COG3385	transposase activity
HPY11_RS13040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY11_RS13045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_RS13045	COG1263	PTS System
HPY11_RS13050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY11_RS13065	COG0514	ATP-dependent DNA helicase (RecQ)
HPY11_RS13070	COG2962	Rard protein
HPY11_RS13075	COG0405	Gamma-glutamyltransferase
HPY11_RS13085	COG1280	lysine exporter protein (LysE YggA)
HPY11_RS13090	COG0210	DNA helicase
HPY11_RS13100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY11_RS13105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY11_RS13115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_RS13125	COG0747	negative chemotaxis
HPY11_RS13220	COG4964	Belongs to the GSP D family
HPY11_RS13255	COG1309	transcriptional regulator
HPY11_RS13260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY11_RS13265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY11_RS13270	COG2960	long-chain fatty acid transporting porin activity
HPY11_RS13275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY11_RS13280	COG0583	DNA-binding transcription factor activity
HPY11_RS13345	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY11_RS13350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY11_RS13355	COG1739	Uncharacterized protein family UPF0029
HPY11_RS13360	COG1024	Enoyl-CoA hydratase
HPY11_RS13360	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY11_RS13365	COG0183	Belongs to the thiolase family
HPY11_RS13370	COG0583	DNA-binding transcription factor activity
HPY11_RS13375	COG2814	Major facilitator Superfamily
HPY11_RS13385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY11_RS13390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY11_RS13395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY11_RS13400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY11_RS13405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY11_RS13410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY11_RS13420	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY11_RS13425	COG3312	ion transport
HPY11_RS13430	COG1475	DNA binding
HPY11_RS13435	COG1192	Involved in chromosome partitioning
HPY11_RS13440	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY11_RS13445	COG0445	tRNA wobble uridine modification
HPY11_RS13450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY11_RS13545	COG4974	Belongs to the 'phage' integrase family
HPY11_RS13550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY11_RS13555	COG0706	membrane insertase activity
HPY11_RS13565	COG0594	ribonuclease P activity
HPY11_RS13570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY11_RS13575	COG1126	abc transporter atp-binding protein
HPY11_RS13620	COG0217	transcriptional regulatory protein
HPY11_RS13625	COG2084	Dehydrogenase
HPY11_RS13640	COG2909	trisaccharide binding
HPY11_RS13645	COG0058	SHG alpha-glucan phosphorylase activity
HPY11_RS13650	COG1640	4-alpha-glucanotransferase
HPY11_RS13655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY11_RS13665	COG3501	Rhs element vgr protein
HPY11_RS13700	COG0471	metal ion transport
HPY11_RS13705	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY11_RS13735	COG0671	phosphoesterase, PA-phosphatase related
HPY11_RS13745	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY11_RS13755	COG1999	signal sequence binding
HPY11_RS13770	COG0786	glutamate:sodium symporter activity
HPY11_RS13790	COG1566	PFAM secretion protein HlyD family protein
HPY11_RS13800	COG3706	GGDEF domain
HPY11_RS13815	COG0813	purine-nucleoside phosphorylase activity
HPY11_RS13820	COG3272	Protein of unknown function (DUF1722)
HPY11_RS13830	COG0415	Belongs to the DNA photolyase family
HPY11_RS13835	COG1388	LysM domain
HPY11_RS13835	COG1376	ErfK ybiS ycfS ynhG family protein
HPY11_RS13845	COG0513	Belongs to the DEAD box helicase family
HPY11_RS13850	COG1770	oligopeptidase
HPY11_RS13880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY11_RS13885	COG0573	inorganic phosphate transmembrane transporter activity
HPY11_RS13890	COG0581	inorganic phosphate transmembrane transporter activity
HPY11_RS13895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY11_RS13915	COG0659	secondary active sulfate transmembrane transporter activity
HPY11_RS13925	COG0739	heme binding
HPY11_RS13930	COG3300	MHYT domain
HPY11_RS13930	COG5001	Diguanylate cyclase
HPY11_RS13935	COG0583	DNA-binding transcription factor activity
HPY11_RS13940	COG2814	Major facilitator Superfamily
HPY11_RS13960	COG1301	dicarboxylic acid transport
HPY11_RS13975	COG1342	Belongs to the UPF0251 family
HPY11_RS14005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY11_RS14010	COG0673	inositol 2-dehydrogenase activity
HPY11_RS14020	COG2200	EAL domain
HPY11_RS14020	COG2771	luxR family
HPY11_RS14025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY11_RS14035	COG0564	pseudouridine synthase activity
HPY11_RS14145	COG1869	D-ribose catabolic process
HPY11_RS14150	COG1129	ABC transporter
HPY11_RS14155	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY11_RS14160	COG1879	ABC-type sugar transport system periplasmic component
HPY11_RS14165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_RS14170	COG1609	Transcriptional regulator
HPY11_RS14180	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY11_RS14190	COG0584	glycerophosphoryl diester phosphodiesterase
HPY11_RS14195	COG2271	Major facilitator Superfamily
HPY11_RS14230	COG0579	oxidoreductase
HPY11_RS14240	COG0242	peptide deformylase activity
HPY11_RS14245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY11_RS14245	COG1017	nitric oxide dioxygenase activity
HPY11_RS14250	COG1320	monovalent cation:proton antiporter activity
HPY11_RS14255	COG2212	antiporter activity
HPY11_RS14275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY11_RS14275	COG2111	Na H antiporter
HPY11_RS14285	COG0589	response to stress
HPY11_RS14290	COG0814	amino acid
HPY11_RS14305	COG3530	Putative quorum-sensing-regulated virulence factor
HPY11_RS14315	COG5002	protein histidine kinase activity
HPY11_RS14315	COG5001	Diguanylate cyclase
HPY11_RS14320	COG1278	Cold shock
HPY11_RS14335	COG2304	oxidoreductase activity
HPY11_RS14355	COG0714	Associated with various cellular activities
HPY11_RS14360	COG0840	transmembrane signaling receptor activity
HPY11_RS14375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY11_RS14380	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY11_RS14390	COG3604	Transcriptional regulator
HPY11_RS14395	COG1017	nitric oxide dioxygenase activity
HPY11_RS14395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY11_RS14400	COG1278	Cold shock
HPY11_RS14405	COG3036	rescue of stalled ribosome
HPY11_RS14430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY11_RS14430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY11_RS14435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY11_RS14445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY11_RS14455	COG0516	GMP reductase activity
HPY11_RS14480	COG0513	Belongs to the DEAD box helicase family
HPY11_RS14485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY11_RS14490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY11_RS14495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY11_RS14500	COG0784	Response regulator, receiver
HPY11_RS14500	COG3437	response regulator, receiver
HPY11_RS14505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_RS14505	COG4191	Histidine kinase
HPY11_RS14515	COG1757	Na H antiporter
HPY11_RS14520	COG2814	Major facilitator Superfamily
HPY11_RS14530	COG3706	GGDEF domain
HPY11_RS14535	COG3240	lipase activity
HPY11_RS14550	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY11_RS14555	COG5380	lipid catabolic process
HPY11_RS14580	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_RS14585	COG4605	iron ion homeostasis
HPY11_RS14590	COG4604	ABC transporter, ATP-binding protein
HPY11_RS14595	COG2207	Transcriptional regulator
HPY11_RS14610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY11_RS14625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY11_RS14635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_RS14645	COG0583	DNA-binding transcription factor activity
HPY11_RS14660	COG0745	RESPONSE REGULATOR receiver
HPY11_RS14670	COG3623	hexulose-6-phosphate isomerase
HPY11_RS14675	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY11_RS14680	COG0561	phosphatase activity
HPY11_RS14715	COG0366	Alpha amylase catalytic
HPY11_RS14735	COG0745	RESPONSE REGULATOR receiver
HPY11_RS14790	COG1686	Belongs to the peptidase S11 family
HPY11_RS14810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY11_RS14810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY11_RS14815	COG0509	glycine decarboxylation via glycine cleavage system
HPY11_RS14820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY11_RS14830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY11_RS14845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY11_RS14850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY11_RS14920	COG0346	lactoylglutathione lyase activity
HPY11_RS15220	COG0625	glutathione transferase activity
HPY11_RS15280	COG0384	phenazine biosynthesis protein PhzF
HPY11_RS15285	COG0346	lactoylglutathione lyase activity
HPY11_RS15330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_RS15435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_RS15600	COG3040	lipid binding
HPY11_RS15615	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY11_RS15690	COG0346	lactoylglutathione lyase activity
HPY11_RS15765	COG0456	acetyltransferase
HPY11_RS15815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_RS15815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_RS15820	COG0494	nUDIX hydrolase
HPY11_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
HPY11_RS15860	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY11_RS15895	COG0384	phenazine biosynthesis protein PhzF
HPY11_RS16040	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY11_RS16065	COG0384	phenazine biosynthesis protein PhzF
HPY11_RS16075	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPY11_RS16080	COG2944	sequence-specific DNA binding
HPY11_RS16140	COG0346	lactoylglutathione lyase activity
HPY11_RS16175	COG0384	phenazine biosynthesis protein PhzF
HPY11_RS16200	COG5642	Protein of unknown function (DUF2384)
HPY11_RS16205	COG0384	phenazine biosynthesis protein PhzF
HPY11_RS16220	COG0494	nUDIX hydrolase
HPY11_RS16225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY11_RS16235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_RS16235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY11_RS16265	COG3040	lipid binding
HPY11_RS16315	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY11_RS16330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY11_RS16335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_RS16340	COG1621	beta-fructofuranosidase activity
HPY11_RS16350	COG1263	PTS System
HPY11_RS16350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY11_RS16430	COG0778	Nitroreductase
HPY11_RS16435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY11_RS16440	COG0583	DNA-binding transcription factor activity
HPY11_RS16465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY11_RS16500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY11_RS16510	COG2390	Transcriptional regulator
HPY11_RS16520	COG2897	thiosulfate sulfurtransferase activity
HPY11_RS16530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY11_RS16540	COG0302	gtp cyclohydrolase
HPY11_RS16545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_RS16545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY11_RS16550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY11_RS16555	COG1970	mechanosensitive ion channel activity
HPY11_RS16560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY11_RS16570	COG1011	Hydrolase
HPY11_RS16575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY11_RS16580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY11_RS16590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY11_RS16600	COG3842	ATPase activity
HPY11_RS16620	COG3104	oligopeptide transport
HPY11_RS16645	COG4166	transmembrane transport
HPY11_RS16650	COG4174	ABC transporter (Permease)
HPY11_RS16655	COG4239	(ABC) transporter, permease
HPY11_RS16660	COG4172	Belongs to the ABC transporter superfamily
HPY11_RS16665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY11_RS16680	COG0625	glutathione transferase activity
HPY11_RS16700	COG2050	protein possibly involved in aromatic compounds catabolism
HPY11_RS16720	COG4771	TonB-dependent receptor
HPY11_RS16720	COG1629	transport
HPY11_RS16725	COG0583	DNA-binding transcription factor activity
HPY11_RS16730	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY11_RS16730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_RS16730	COG1042	CoA-binding domain protein
HPY11_RS16750	COG0023	Translation Initiation Factor
HPY11_RS16805	COG3140	Belongs to the UPF0181 family
HPY11_RS16820	COG0745	RESPONSE REGULATOR receiver
HPY11_RS16830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY11_RS16835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY11_RS16850	COG3706	GGDEF domain
HPY11_RS16905	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY11_RS16910	COG3385	transposase activity
HPY11_RS16925	COG0737	Belongs to the 5'-nucleotidase family
HPY11_RS16930	COG3593	DNA synthesis involved in DNA repair
HPY11_RS16940	COG0583	DNA-binding transcription factor activity
HPY11_RS16945	COG2116	formate transmembrane transporter activity
HPY11_RS16955	COG3038	cytochrome b561
HPY11_RS16965	COG2200	EAL domain
HPY11_RS16980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY11_RS16985	COG0745	RESPONSE REGULATOR receiver
HPY11_RS16990	COG2205	protein histidine kinase activity
HPY11_RS16995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY11_RS16995	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY11_RS16995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY11_RS16995	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY11_RS17000	COG3158	transport of potassium into the cell
HPY11_RS17010	COG0523	cobalamin synthesis protein
HPY11_RS17015	COG0038	chloride channel
HPY11_RS17025	COG0156	8-amino-7-oxononanoate synthase activity
HPY11_RS17030	COG0784	Response regulator, receiver
HPY11_RS17030	COG2205	protein histidine kinase activity
HPY11_RS17035	COG0419	ATPase involved in DNA repair
HPY11_RS17040	COG0420	3'-5' exonuclease activity
HPY11_RS17045	COG1609	Transcriptional regulator
HPY11_RS17050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_RS17050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_RS17055	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY11_RS17060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_RS17060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY11_RS17060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY11_RS17065	COG0189	ligase activity
HPY11_RS17065	COG4067	protein conserved in archaea
HPY11_RS17075	COG0602	queuosine metabolic process
HPY11_RS17080	COG1328	CTP reductase activity
HPY11_RS17090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY11_RS17095	COG0840	transmembrane signaling receptor activity
HPY11_RS17100	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY11_RS17105	COG1760	l-serine dehydratase
HPY11_RS17110	COG2197	response regulator
HPY11_RS17115	COG3850	Histidine kinase
HPY11_RS17120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY11_RS17130	COG0243	molybdopterin cofactor binding
HPY11_RS17150	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY11_RS17155	COG2197	response regulator
HPY11_RS17160	COG3851	Histidine kinase
HPY11_RS17165	COG2271	Major facilitator Superfamily
HPY11_RS17170	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY11_RS17180	COG3842	ATPase activity
HPY11_RS17185	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY11_RS17195	COG0183	Belongs to the thiolase family
HPY11_RS17205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_RS17210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY11_RS17225	COG3706	GGDEF domain
HPY11_RS17230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY11_RS17240	COG1979	alcohol dehydrogenase
HPY11_RS17255	COG4191	Histidine kinase
HPY11_RS17265	COG2271	Major facilitator Superfamily
HPY11_RS17270	COG0469	pyruvate kinase activity
HPY11_RS17280	COG1879	ABC-type sugar transport system periplasmic component
HPY11_RS17285	COG1803	Methylglyoxal synthase
HPY11_RS17290	COG1335	isochorismatase
HPY11_RS17295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY11_RS17300	COG0210	DNA helicase
HPY11_RS17305	COG1289	transmembrane transporter activity
HPY11_RS17335	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY11_RS17340	COG4149	molybdate abc transporter
HPY11_RS17345	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY11_RS17350	COG1492	cobalamin metabolic process
HPY11_RS17400	COG2814	Major facilitator Superfamily
HPY11_RS17405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY11_RS17405	COG2226	methyltransferase
HPY11_RS17405	COG3433	isochorismatase activity
HPY11_RS17430	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY11_RS17435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY11_RS17455	COG1132	(ABC) transporter
HPY11_RS17460	COG1132	(ABC) transporter
HPY11_RS17470	COG0784	Response regulator, receiver
HPY11_RS17470	COG5002	protein histidine kinase activity
HPY11_RS17475	COG1879	ABC-type sugar transport system periplasmic component
HPY11_RS17485	COG2827	Endonuclease containing a URI domain
HPY11_RS17490	COG3132	Protein of unknown function, DUF480
HPY11_RS17500	COG2926	Belongs to the UPF0265 family
HPY11_RS17510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY11_RS17515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY11_RS17520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY11_RS17525	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPY11_RS17530	COG0247	lactate metabolic process
HPY11_RS17535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY11_RS17540	COG3118	belongs to the thioredoxin family
HPY11_RS17565	COG4160	amino acid transport
HPY11_RS17570	COG4215	(ABC) transporter
HPY11_RS17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_RS17580	COG1126	abc transporter atp-binding protein
HPY11_RS17590	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY11_RS17600	COG0494	nUDIX hydrolase
HPY11_RS17605	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY11_RS17615	COG1309	transcriptional regulator
HPY11_RS17620	COG0513	Belongs to the DEAD box helicase family
HPY11_RS17625	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY11_RS17630	COG0814	amino acid
HPY11_RS17635	COG0840	transmembrane signaling receptor activity
HPY11_RS17640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY11_RS17645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY11_RS17655	COG1984	allophanate hydrolase subunit 2
HPY11_RS17670	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY11_RS17675	COG4181	ATPase activity
HPY11_RS17685	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY11_RS17690	COG1716	ATPase activity
HPY11_RS17690	COG5001	Diguanylate cyclase
HPY11_RS17700	COG0484	heat shock protein binding
HPY11_RS17715	COG0546	phosphoglycolate phosphatase activity
HPY11_RS17730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_RS17735	COG1368	sulfuric ester hydrolase activity
HPY11_RS17745	COG0513	Belongs to the DEAD box helicase family
HPY11_RS17760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY11_RS17770	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY11_RS17775	COG3397	chitin binding
HPY11_RS17780	COG3227	Zinc metalloprotease (Elastase)
HPY11_RS17795	COG1166	arginine decarboxylase activity
HPY11_RS17805	COG2239	Acts as a magnesium transporter
HPY11_RS17815	COG0527	aspartate kinase activity
HPY11_RS17825	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY11_RS17830	COG3186	Phenylalanine-4-hydroxylase
HPY11_RS17835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY11_RS17850	COG2264	protein methyltransferase activity
HPY11_RS17875	COG1253	flavin adenine dinucleotide binding
HPY11_RS17880	COG1765	OsmC-like protein
HPY11_RS17905	COG0531	amino acid
HPY11_RS17910	COG3706	GGDEF domain
HPY11_RS17920	COG4989	oxidoreductase activity
HPY11_RS17925	COG0366	Alpha amylase catalytic
HPY11_RS17935	COG2067	long-chain fatty acid transport protein
HPY11_RS17940	COG2267	carboxylic ester hydrolase activity
HPY11_RS17950	COG3227	Zinc metalloprotease (Elastase)
HPY11_RS17955	COG3047	cAMP biosynthetic process
HPY11_RS17965	COG1686	Belongs to the peptidase S11 family
HPY11_RS17970	COG0557	exoribonuclease II activity
HPY11_RS17975	COG1278	Cold shock
HPY11_RS17985	COG3048	D-serine ammonia-lyase activity
HPY11_RS17990	COG0583	DNA-binding transcription factor activity
HPY11_RS18010	COG2801	Transposase and inactivated derivatives
HPY11_RS18015	COG5002	protein histidine kinase activity
HPY11_RS18040	COG0582	viral genome integration into host DNA
HPY11_RS18060	COG1063	alcohol dehydrogenase
HPY11_RS18065	COG0156	8-amino-7-oxononanoate synthase activity
HPY11_RS18070	COG2873	o-acetylhomoserine
HPY11_RS18080	COG0346	lactoylglutathione lyase activity
HPY11_RS18105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY11_RS18110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY11_RS18115	COG0363	glucosamine-6-phosphate deaminase activity
HPY11_RS18120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY11_RS18145	COG1929	Belongs to the glycerate kinase type-1 family
HPY11_RS18150	COG2610	gluconate transmembrane transporter activity
HPY11_RS18155	COG3835	regulator
HPY11_RS18165	COG0748	coenzyme F420 binding
HPY11_RS18170	COG3721	Heme iron utilization protein
HPY11_RS18180	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY11_RS18185	COG0811	peptide transport
HPY11_RS18190	COG0848	biopolymer transport protein
HPY11_RS18195	COG4558	Periplasmic binding protein
HPY11_RS18200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY11_RS18205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY11_RS18240	COG0633	Ferredoxin
HPY11_RS18240	COG3217	Mosc domain protein beta barrel domain protein
HPY11_RS18240	COG0633	Ferredoxin
HPY11_RS18240	COG3217	Mosc domain protein beta barrel domain protein
HPY11_RS18245	COG0418	dihydroorotase activity
HPY11_RS18250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY11_RS18255	COG2354	Protein conserved in bacteria
HPY11_RS18265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY11_RS18270	COG1278	Cold shock
HPY11_RS18295	COG3706	GGDEF domain
HPY11_RS18300	COG1349	DNA-binding transcription factor activity
HPY11_RS18315	COG3833	ABC-type maltose transport systems, permease component
HPY11_RS18320	COG1175	transmembrane transport
HPY11_RS18330	COG3842	ATPase activity
HPY11_RS18335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY11_RS18350	COG0393	Putative heavy-metal-binding
HPY11_RS18360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY11_RS18365	COG0835	chemotaxis
HPY11_RS18365	COG0784	Response regulator, receiver
HPY11_RS18370	COG1846	Transcriptional regulator
HPY11_RS18375	COG3706	GGDEF domain
HPY11_RS18410	COG0583	DNA-binding transcription factor activity
HPY11_RS18415	COG5001	Diguanylate cyclase
HPY11_RS18425	COG1741	Belongs to the pirin family
HPY11_RS18430	COG3123	guanosine phosphorylase activity
HPY11_RS18440	COG2211	Major facilitator Superfamily
HPY11_RS18450	COG1067	ATP-dependent peptidase activity
HPY11_RS18460	COG4172	Belongs to the ABC transporter superfamily
HPY11_RS18480	COG0583	DNA-binding transcription factor activity
HPY11_RS18490	COG1620	l-lactate permease
HPY11_RS18505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY11_RS18515	COG0840	transmembrane signaling receptor activity
HPY11_RS18535	COG2258	MOSC domain
HPY11_RS18540	COG0513	Belongs to the DEAD box helicase family
HPY11_RS18550	COG2186	Transcriptional regulator
HPY11_RS18560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY11_RS18570	COG0246	Mannitol dehydrogenase
HPY11_RS18575	COG1904	glucuronate isomerase
HPY11_RS18580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY11_RS18585	COG0800	Aldolase
HPY11_RS18595	COG0583	DNA-binding transcription factor activity
HPY11_RS18605	COG1902	pentaerythritol trinitrate reductase activity
HPY11_RS18615	COG1132	(ABC) transporter
HPY11_RS18625	COG1902	pentaerythritol trinitrate reductase activity
HPY11_RS18635	COG1280	lysine exporter protein (LysE YggA)
HPY11_RS18640	COG2207	Transcriptional regulator
HPY11_RS18660	COG1846	Transcriptional regulator
HPY11_RS18665	COG1764	response to oxidative stress
HPY11_RS18670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY11_RS18675	COG0697	spore germination
HPY11_RS18685	COG0700	Nucleoside recognition
HPY11_RS18690	COG3366	ferrous iron transmembrane transporter activity
HPY11_RS18695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY11_RS18705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY11_RS18710	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY11_RS18715	COG2259	Doxx family
HPY11_RS18740	COG0363	glucosamine-6-phosphate deaminase activity
HPY11_RS18755	COG4580	involved in the transport of maltose and maltodextrins
HPY11_RS18770	COG0840	transmembrane signaling receptor activity
HPY11_RS18780	COG0840	transmembrane signaling receptor activity
HPY11_RS18785	COG3706	GGDEF domain
HPY11_RS18795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY11_RS18800	COG1126	abc transporter atp-binding protein
HPY11_RS18810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY11_RS18815	COG4597	amino acid ABC transporter
HPY11_RS18820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY11_RS18825	COG2213	PTS system mannitol-specific
HPY11_RS18825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY11_RS18830	COG0246	Mannitol dehydrogenase
HPY11_RS18835	COG3722	fumarate hydratase activity
HPY11_RS18870	COG2910	NAD(P)H-binding
HPY11_RS18880	COG0840	transmembrane signaling receptor activity
HPY11_RS18885	COG4221	oxidoreductase activity
HPY11_RS18895	COG1901	pseudouridine methyltransferase
HPY11_RS18910	COG0531	amino acid
HPY11_RS18915	COG1982	Orn Lys Arg decarboxylase major
HPY11_RS18925	COG2197	response regulator
HPY11_RS18975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY11_RS19000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY11_RS19065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY11_RS19070	COG0840	transmembrane signaling receptor activity
HPY11_RS19075	COG0835	chemotaxis
HPY11_RS19080	COG0835	chemotaxis
HPY11_RS19085	COG2198	Histidine kinase
HPY11_RS19085	COG0643	Histidine kinase
HPY11_RS19105	COG0601	transmembrane transport
HPY11_RS19110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY11_RS19115	COG4608	Belongs to the ABC transporter superfamily
HPY11_RS19120	COG1444	tRNA N-acetyltransferase activity
HPY11_RS19125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine