locus-tag	class	description
HPY04_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY04_RS00010	COG0592	DNA-directed DNA polymerase activity
HPY04_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY04_RS00020	COG0187	DNA topoisomerase II activity
HPY04_RS00075	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY04_RS00080	COG3977	Valine--pyruvate aminotransferase
HPY04_RS00085	COG0751	glycine-tRNA ligase activity
HPY04_RS00090	COG0752	glycyl-tRNA synthetase alpha subunit
HPY04_RS00095	COG2119	membrane
HPY04_RS00105	COG0425	Belongs to the sulfur carrier protein TusA family
HPY04_RS00115	COG0604	alcohol dehydrogenase
HPY04_RS00125	COG0129	dihydroxy-acid dehydratase activity
HPY04_RS00130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY04_RS00145	COG0606	chelatase, subunit chli
HPY04_RS00150	COG0204	Acyl-transferase
HPY04_RS00155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY04_RS00160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY04_RS00170	COG3084	Protein conserved in bacteria
HPY04_RS00180	COG4326	sporulation control protein
HPY04_RS00185	COG1272	protein, Hemolysin III
HPY04_RS00195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY04_RS00200	COG0569	domain protein
HPY04_RS00205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY04_RS00205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY04_RS00210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY04_RS00215	COG0242	peptide deformylase activity
HPY04_RS00220	COG1652	LysM domain
HPY04_RS00225	COG0758	DNA mediated transformation
HPY04_RS00230	COG2922	Belongs to the Smg family
HPY04_RS00235	COG0551	DNA topoisomerase type I activity
HPY04_RS00240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY04_RS00245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY04_RS00250	COG0009	L-threonylcarbamoyladenylate synthase
HPY04_RS00255	COG0408	coproporphyrinogen oxidase activity
HPY04_RS00260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY04_RS00270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY04_RS00310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY04_RS00315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY04_RS00325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY04_RS00330	COG2104	thiamine diphosphate biosynthetic process
HPY04_RS00335	COG2022	thiamine diphosphate biosynthetic process
HPY04_RS00340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY04_RS00345	COG0006	proline dipeptidase activity
HPY04_RS00345	COG0006	proline dipeptidase activity
HPY04_RS00365	COG1522	sequence-specific DNA binding
HPY04_RS00370	COG5001	Diguanylate cyclase
HPY04_RS00370	COG5002	protein histidine kinase activity
HPY04_RS00390	COG0589	response to stress
HPY04_RS00395	COG1528	Iron-storage protein
HPY04_RS00405	COG2081	HI0933 family
HPY04_RS00415	COG1322	Protein conserved in bacteria
HPY04_RS00420	COG2226	methyltransferase
HPY04_RS00435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY04_RS00440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY04_RS00445	COG0805	protein transport
HPY04_RS00450	COG1858	cytochrome C peroxidase
HPY04_RS00455	COG0534	Mate efflux family protein
HPY04_RS00465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY04_RS00470	COG2937	Belongs to the GPAT DAPAT family
HPY04_RS00475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY04_RS00480	COG3161	chorismate lyase activity
HPY04_RS00485	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY04_RS00490	COG0840	transmembrane signaling receptor activity
HPY04_RS00500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY04_RS00505	COG0084	hydrolase, TatD family'
HPY04_RS00520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY04_RS00520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY04_RS00540	COG3078	GTPase activator activity
HPY04_RS00555	COG3071	HemY protein
HPY04_RS00560	COG2959	enzyme of heme biosynthesis
HPY04_RS00565	COG1587	Uroporphyrinogen-III synthase
HPY04_RS00570	COG0181	hydroxymethylbilane synthase activity
HPY04_RS00580	COG1965	Belongs to the frataxin family
HPY04_RS00590	COG0019	diaminopimelate decarboxylase activity
HPY04_RS00595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY04_RS00605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY04_RS00610	COG1011	Hydrolase
HPY04_RS00615	COG2199	diguanylate cyclase activity
HPY04_RS00615	COG3287	FIST C domain
HPY04_RS00615	COG2200	EAL domain
HPY04_RS00630	COG0561	phosphatase activity
HPY04_RS00635	COG2267	carboxylic ester hydrolase activity
HPY04_RS00640	COG1280	lysine exporter protein (LysE YggA)
HPY04_RS00645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY04_RS00650	COG0783	Belongs to the Dps family
HPY04_RS00680	COG0742	ribosomal rna small subunit methyltransferase
HPY04_RS00685	COG0552	protein localization to endoplasmic reticulum
HPY04_RS00690	COG2884	Cell division ATP-binding protein ftsE
HPY04_RS00695	COG2177	Part of the ABC transporter FtsEX involved in
HPY04_RS00700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY04_RS00705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_RS00720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY04_RS00725	COG4206	TonB-dependent receptor
HPY04_RS00730	COG1404	Belongs to the peptidase S8 family
HPY04_RS00735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY04_RS00805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY04_RS00810	COG3300	MHYT domain
HPY04_RS00810	COG5001	Diguanylate cyclase
HPY04_RS00820	COG3852	Histidine kinase
HPY04_RS00830	COG0174	glutamine synthetase
HPY04_RS00850	COG1295	ribonuclease BN
HPY04_RS00855	COG1490	D-aminoacyl-tRNA deacylase activity
HPY04_RS00860	COG0456	acetyltransferase
HPY04_RS00870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY04_RS00875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY04_RS00880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY04_RS00885	COG3031	protein transport across the cell outer membrane
HPY04_RS00895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY04_RS00900	COG1459	type II secretion system
HPY04_RS00905	COG2165	general secretion pathway protein
HPY04_RS00910	COG2165	general secretion pathway protein
HPY04_RS00915	COG2165	general secretion pathway protein
HPY04_RS00920	COG4795	General secretion pathway protein
HPY04_RS00925	COG3156	type II secretion system protein K
HPY04_RS00930	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY04_RS00935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY04_RS00945	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY04_RS00950	COG0494	nUDIX hydrolase
HPY04_RS00960	COG1040	competence protein
HPY04_RS00970	COG0596	Alpha beta hydrolase
HPY04_RS00980	COG2183	response to ionizing radiation
HPY04_RS00985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY04_RS00990	COG2199	diguanylate cyclase activity
HPY04_RS00995	COG0745	RESPONSE REGULATOR receiver
HPY04_RS01005	COG2233	PERMEase
HPY04_RS01010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY04_RS01015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY04_RS01020	COG1758	RNA polymerase activity
HPY04_RS01025	COG0194	GDP metabolic process
HPY04_RS01030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY04_RS01035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY04_RS01055	COG4232	protein-disulfide reductase activity
HPY04_RS01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY04_RS01070	COG1027	Aspartate ammonia-lyase
HPY04_RS01075	COG3706	GGDEF domain
HPY04_RS01080	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY04_RS01085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY04_RS01095	COG2205	protein histidine kinase activity
HPY04_RS01100	COG0745	RESPONSE REGULATOR receiver
HPY04_RS01110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY04_RS01115	COG0205	6-phosphofructokinase activity
HPY04_RS01120	COG1494	fructose-1,6-bisphosphatase
HPY04_RS01125	COG3074	FtsZ-dependent cytokinesis
HPY04_RS01130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY04_RS01135	COG0527	aspartate kinase activity
HPY04_RS01135	COG0460	homoserine dehydrogenase
HPY04_RS01140	COG0626	cystathionine gamma-synthase activity
HPY04_RS01145	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY04_RS01150	COG0281	malic enzyme
HPY04_RS01155	COG0254	rRNA binding
HPY04_RS01160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY04_RS01165	COG1609	Transcriptional regulator
HPY04_RS01170	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY04_RS01175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY04_RS01180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY04_RS01185	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY04_RS01190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY04_RS01195	COG0534	Mate efflux family protein
HPY04_RS01200	COG0149	triose-phosphate isomerase activity
HPY04_RS01225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY04_RS01230	COG0459	protein refolding
HPY04_RS01235	COG3344	reverse transcriptase
HPY04_RS01250	COG1509	lysine 2,3-aminomutase activity
HPY04_RS01255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY04_RS01265	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY04_RS01270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY04_RS01275	COG1053	succinate dehydrogenase
HPY04_RS01280	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY04_RS01285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY04_RS01290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY04_RS01295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY04_RS01300	COG1045	serine acetyltransferase
HPY04_RS01310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY04_RS01315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY04_RS01320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY04_RS01325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY04_RS01330	COG0137	argininosuccinate synthase activity
HPY04_RS01335	COG0165	Argininosuccinate lyase
HPY04_RS01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_RS01350	COG0678	peroxiredoxin activity
HPY04_RS01350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY04_RS01360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY04_RS01390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY04_RS01395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY04_RS01405	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY04_RS01410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY04_RS01415	COG0546	phosphoglycolate phosphatase activity
HPY04_RS01420	COG0180	Tryptophanyl-tRNA synthetase
HPY04_RS01435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY04_RS01445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY04_RS01470	COG3954	Phosphoribulokinase
HPY04_RS01480	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY04_RS01490	COG0488	(ABC) transporter
HPY04_RS01495	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY04_RS01510	COG1047	Peptidyl-prolyl cis-trans
HPY04_RS01520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY04_RS01525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY04_RS01535	COG0557	exoribonuclease II activity
HPY04_RS01540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY04_RS01545	COG0051	transcription antitermination factor activity, RNA binding
HPY04_RS01550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY04_RS01555	COG0088	Forms part of the polypeptide exit tunnel
HPY04_RS01560	COG0089	rRNA binding
HPY04_RS01565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY04_RS01570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY04_RS01575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY04_RS01580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY04_RS01585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY04_RS01590	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY04_RS01595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY04_RS01600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY04_RS01605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY04_RS01610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY04_RS01615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY04_RS01620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY04_RS01630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY04_RS01635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY04_RS01640	COG1841	ribosomal large subunit assembly
HPY04_RS01650	COG0201	protein transport
HPY04_RS01655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY04_RS01660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY04_RS01665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY04_RS01670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY04_RS01675	COG0202	RNA polymerase activity
HPY04_RS01680	COG0203	ribosomal protein L17
HPY04_RS01690	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY04_RS01695	COG3061	Opacity-associated protein A
HPY04_RS01695	COG3266	domain, Protein
HPY04_RS01700	COG0697	spore germination
HPY04_RS01705	COG2153	protein acetylation
HPY04_RS01710	COG0513	Belongs to the DEAD box helicase family
HPY04_RS01720	COG0737	Belongs to the 5'-nucleotidase family
HPY04_RS01725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY04_RS01725	COG1648	precorrin-2 dehydrogenase activity
HPY04_RS01730	COG0175	sulfate reduction
HPY04_RS01735	COG2895	sulfate adenylyltransferase (ATP) activity
HPY04_RS01740	COG0529	Catalyzes the synthesis of activated sulfate
HPY04_RS01760	COG1136	(ABC) transporter
HPY04_RS01775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY04_RS01780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_RS01785	COG0729	surface antigen
HPY04_RS01795	COG2105	PFAM AIG2 family protein
HPY04_RS01800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY04_RS01810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY04_RS01815	COG0163	prenyltransferase activity
HPY04_RS01825	COG1178	ABC-type Fe3 transport system permease component
HPY04_RS01830	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY04_RS01835	COG3028	Belongs to the UPF0307 family
HPY04_RS01840	COG0312	modulator of DNA gyrase
HPY04_RS01845	COG2239	Acts as a magnesium transporter
HPY04_RS01850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_RS01855	COG1660	Displays ATPase and GTPase activities
HPY04_RS01860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_RS01865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY04_RS01875	COG1137	ATPase activity
HPY04_RS01880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY04_RS01895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY04_RS01895	COG0517	IMP dehydrogenase activity
HPY04_RS01905	COG1127	ABC transporter
HPY04_RS01910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY04_RS01915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY04_RS01920	COG2854	intermembrane phospholipid transfer
HPY04_RS01930	COG5007	Belongs to the BolA IbaG family
HPY04_RS01935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY04_RS01945	COG0251	oxidation-reduction process
HPY04_RS01955	COG0540	Belongs to the ATCase OTCase family
HPY04_RS01965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY04_RS01975	COG0564	pseudouridine synthase activity
HPY04_RS01980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY04_RS01985	COG0525	valine-tRNA ligase activity
HPY04_RS01990	COG2927	DNA polymerase III (CHI subunit)
HPY04_RS01995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY04_RS02000	COG0795	lipopolysaccharide-transporting ATPase activity
HPY04_RS02005	COG0795	lipopolysaccharide-transporting ATPase activity
HPY04_RS02020	COG3437	response regulator, receiver
HPY04_RS02065	COG0066	3-isopropylmalate dehydratase activity
HPY04_RS02070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY04_RS02075	COG0473	3-isopropylmalate dehydrogenase activity
HPY04_RS02095	COG0583	DNA-binding transcription factor activity
HPY04_RS02100	COG1022	Amp-dependent synthetase and ligase
HPY04_RS02105	COG0028	Belongs to the TPP enzyme family
HPY04_RS02110	COG0440	acetolactate synthase activity
HPY04_RS02115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY04_RS02120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY04_RS02125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY04_RS02135	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY04_RS02140	COG3079	Belongs to the UPF0149 family
HPY04_RS02145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_RS02150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_RS02165	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY04_RS02175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY04_RS02180	COG1595	DNA-templated transcription, initiation
HPY04_RS02195	COG3086	response to oxidative stress
HPY04_RS02200	COG0481	GTPase activity
HPY04_RS02210	COG0571	ribonuclease III activity
HPY04_RS02215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY04_RS02220	COG1381	Involved in DNA repair and RecF pathway recombination
HPY04_RS02225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY04_RS02230	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY04_RS02245	COG5001	Diguanylate cyclase
HPY04_RS02255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY04_RS02260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY04_RS02265	COG3956	TIGRFAM MazG family protein
HPY04_RS02270	COG0504	CTP synthase activity
HPY04_RS02275	COG0148	phosphopyruvate hydratase activity
HPY04_RS02280	COG0617	tRNA 3'-terminal CCA addition
HPY04_RS02285	COG3409	Peptidoglycan-binding domain 1 protein
HPY04_RS02285	COG3267	Type II secretory pathway component ExeA
HPY04_RS02295	COG4991	sh3 domain protein
HPY04_RS02300	COG0306	phosphate transporter
HPY04_RS02305	COG1392	Phosphate transport regulator
HPY04_RS02310	COG3025	triphosphatase activity
HPY04_RS02315	COG0840	transmembrane signaling receptor activity
HPY04_RS02320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY04_RS02325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY04_RS02325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY04_RS02330	COG1538	Outer membrane efflux protein
HPY04_RS02335	COG0494	nUDIX hydrolase
HPY04_RS02340	COG3151	Protein conserved in bacteria
HPY04_RS02350	COG3150	esterase
HPY04_RS02355	COG0187	DNA topoisomerase II activity
HPY04_RS02360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY04_RS02370	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY04_RS02375	COG0237	dephospho-CoA kinase activity
HPY04_RS02385	COG1459	type II secretion system
HPY04_RS02390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY04_RS02410	COG0716	FMN binding
HPY04_RS02415	COG4974	Belongs to the 'phage' integrase family
HPY04_RS02420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY04_RS02425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY04_RS02430	COG0737	Belongs to the 5'-nucleotidase family
HPY04_RS02435	COG2186	Transcriptional regulator
HPY04_RS02440	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY04_RS02445	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY04_RS02450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_RS02465	COG3116	cell division
HPY04_RS02470	COG0768	penicillin binding
HPY04_RS02475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY04_RS02480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY04_RS02490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY04_RS02495	COG0772	Belongs to the SEDS family
HPY04_RS02500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY04_RS02505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY04_RS02510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY04_RS02515	COG0849	cell division
HPY04_RS02520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY04_RS02525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY04_RS02535	COG0653	protein targeting
HPY04_RS02540	COG0494	nUDIX hydrolase
HPY04_RS02545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY04_RS02555	COG0505	Belongs to the CarA family
HPY04_RS02560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY04_RS02585	COG0730	response to heat
HPY04_RS02590	COG0583	DNA-binding transcription factor activity
HPY04_RS02595	COG2860	membrane
HPY04_RS02600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY04_RS02610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY04_RS02620	COG0493	'glutamate synthase
HPY04_RS02625	COG0070	glutamate synthase
HPY04_RS02625	COG0067	glutamate synthase
HPY04_RS02625	COG0069	glutamate synthase activity
HPY04_RS02635	COG0070	glutamate synthase
HPY04_RS02635	COG0067	glutamate synthase
HPY04_RS02635	COG0069	glutamate synthase activity
HPY04_RS02640	COG1242	4 iron, 4 sulfur cluster binding
HPY04_RS02645	COG4251	negative regulation of phosphorylation
HPY04_RS02645	COG3706	GGDEF domain
HPY04_RS02645	COG5001	Diguanylate cyclase
HPY04_RS02645	COG2203	Gaf domain
HPY04_RS02650	COG5002	protein histidine kinase activity
HPY04_RS02650	COG0784	Response regulator, receiver
HPY04_RS02650	COG2198	Histidine kinase
HPY04_RS02655	COG0745	RESPONSE REGULATOR receiver
HPY04_RS02665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY04_RS02685	COG0083	homoserine kinase activity
HPY04_RS02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY04_RS02695	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY04_RS02700	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY04_RS02705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY04_RS02720	COG1115	amino acid carrier protein
HPY04_RS02725	COG3022	response to hydroperoxide
HPY04_RS02735	COG0084	hydrolase, TatD family'
HPY04_RS02740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY04_RS02750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY04_RS02755	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY04_RS02760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY04_RS02765	COG0813	purine-nucleoside phosphorylase activity
HPY04_RS02775	COG0560	Phosphoserine phosphatase
HPY04_RS02785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY04_RS02790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY04_RS02795	COG1022	Amp-dependent synthetase and ligase
HPY04_RS02810	COG3250	beta-galactosidase activity
HPY04_RS02820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_RS02835	COG0189	ligase activity
HPY04_RS02835	COG0569	domain protein
HPY04_RS02840	COG0456	acetyltransferase
HPY04_RS02850	COG2171	N-acyltransferase activity
HPY04_RS02855	COG3141	response to X-ray
HPY04_RS02870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY04_RS02875	COG1074	ATP-dependent DNA helicase activity
HPY04_RS02880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY04_RS02890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY04_RS02890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY04_RS02900	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY04_RS02905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY04_RS02910	COG2166	iron-sulfur cluster assembly
HPY04_RS02920	COG0693	protein deglycase activity
HPY04_RS02925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY04_RS02930	COG3248	Nucleoside-binding outer membrane protein
HPY04_RS02940	COG1595	DNA-templated transcription, initiation
HPY04_RS02950	COG2211	Major facilitator Superfamily
HPY04_RS02955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY04_RS02965	COG2813	Specifically methylates the guanine in position
HPY04_RS02970	COG0271	Belongs to the BolA IbaG family
HPY04_RS02975	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_RS02980	COG1805	sodium ion transport
HPY04_RS02985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_RS02990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_RS02995	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY04_RS03000	COG2871	sodium ion transport
HPY04_RS03005	COG1477	protein flavinylation
HPY04_RS03025	COG3706	GGDEF domain
HPY04_RS03030	COG0733	neurotransmitter:sodium symporter activity
HPY04_RS03040	COG0189	ligase activity
HPY04_RS03045	COG4067	protein conserved in archaea
HPY04_RS03045	COG0189	ligase activity
HPY04_RS03050	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY04_RS03055	COG2252	PERMEase
HPY04_RS03060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY04_RS03075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY04_RS03080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY04_RS03085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY04_RS03090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY04_RS03090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY04_RS03105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY04_RS03110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY04_RS03115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY04_RS03120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY04_RS03130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY04_RS03135	COG0024	Methionine aminopeptidase
HPY04_RS03140	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY04_RS03145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY04_RS03150	COG0528	UMP kinase activity
HPY04_RS03155	COG0233	cytoplasmic translational termination
HPY04_RS03160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY04_RS03165	COG0575	Belongs to the CDS family
HPY04_RS03170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY04_RS03175	COG0750	zinc metalloprotease
HPY04_RS03185	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY04_RS03190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_RS03195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY04_RS03200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_RS03205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_RS03210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY04_RS03215	COG0587	DNA-directed DNA polymerase activity
HPY04_RS03220	COG0825	malonyl-CoA metabolic process
HPY04_RS03225	COG0037	tRNA processing
HPY04_RS03235	COG3479	Phenolic acid decarboxylase
HPY04_RS03240	COG0347	Belongs to the P(II) protein family
HPY04_RS03245	COG3021	interspecies interaction between organisms
HPY04_RS03250	COG1388	LysM domain
HPY04_RS03250	COG0741	lytic transglycosylase activity
HPY04_RS03255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY04_RS03260	COG2226	methyltransferase
HPY04_RS03265	COG0328	RNA-DNA hybrid ribonuclease activity
HPY04_RS03280	COG1960	acyl-CoA dehydrogenase activity
HPY04_RS03285	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY04_RS03290	COG0121	glutamine amidotransferase
HPY04_RS03295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY04_RS03300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY04_RS03305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY04_RS03310	COG3706	GGDEF domain
HPY04_RS03315	COG1187	pseudouridine synthase activity
HPY04_RS03320	COG2840	Smr protein MutS2
HPY04_RS03350	COG2217	Heavy metal translocating P-type atpase
HPY04_RS03350	COG2608	mercury ion transmembrane transporter activity
HPY04_RS03355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY04_RS03370	COG1629	transport
HPY04_RS03370	COG4774	siderophore transport
HPY04_RS03375	COG2375	cellular response to nickel ion
HPY04_RS03380	COG2226	methyltransferase
HPY04_RS03380	COG3433	isochorismatase activity
HPY04_RS03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY04_RS03415	COG0835	chemotaxis
HPY04_RS03415	COG0784	Response regulator, receiver
HPY04_RS03420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY04_RS03425	COG1815	bacterial-type flagellum-dependent cell motility
HPY04_RS03440	COG1749	Flagellar hook protein flgE
HPY04_RS03445	COG4787	bacterial-type flagellum-dependent cell motility
HPY04_RS03455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY04_RS03460	COG1706	bacterial-type flagellum-dependent cell motility
HPY04_RS03465	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY04_RS03465	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY04_RS03480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_RS03485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_RS03570	COG0012	GTP binding
HPY04_RS03575	COG0193	aminoacyl-tRNA hydrolase activity
HPY04_RS03580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY04_RS03585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY04_RS03590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY04_RS03595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY04_RS03600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY04_RS03605	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY04_RS03615	COG2912	Transglutaminase-like superfamily
HPY04_RS03620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY04_RS03625	COG0737	Belongs to the 5'-nucleotidase family
HPY04_RS03630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY04_RS03635	COG2233	PERMEase
HPY04_RS03655	COG1393	Belongs to the ArsC family
HPY04_RS03660	COG4783	chaperone-mediated protein folding
HPY04_RS03680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY04_RS03695	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY04_RS03705	COG1876	peptidase activity
HPY04_RS03715	COG1393	Belongs to the ArsC family
HPY04_RS03735	COG2837	iron assimilation
HPY04_RS03740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_RS03745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_RS03750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY04_RS03755	COG1334	flagellar protein FlaG
HPY04_RS03760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY04_RS03770	COG1516	flagellar protein fliS
HPY04_RS03780	COG4191	Histidine kinase
HPY04_RS03790	COG1677	Flagellar hook-basal body complex protein FliE
HPY04_RS03800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY04_RS03805	COG1317	bacterial-type flagellum organization
HPY04_RS03830	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY04_RS03855	COG1987	bacterial-type flagellum assembly
HPY04_RS03860	COG1684	flagellar biosynthetic protein fliR
HPY04_RS03870	COG2840	Smr protein MutS2
HPY04_RS03875	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY04_RS03880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY04_RS03885	COG2860	membrane
HPY04_RS03890	COG3101	peptidyl-lysine hydroxylation
HPY04_RS03900	COG0431	NADPH-dependent FMN reductase
HPY04_RS03905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY04_RS03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY04_RS03910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY04_RS03915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY04_RS03920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY04_RS03925	COG0735	belongs to the Fur family
HPY04_RS03935	COG0583	DNA-binding transcription factor activity
HPY04_RS03945	COG1346	cytolysis
HPY04_RS03960	COG0596	Alpha beta hydrolase
HPY04_RS03965	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY04_RS03970	COG0033	Phosphoglucomutase
HPY04_RS03980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY04_RS03985	COG0372	Belongs to the citrate synthase family
HPY04_RS03990	COG2009	succinate dehydrogenase
HPY04_RS03995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY04_RS04000	COG1053	succinate dehydrogenase
HPY04_RS04010	COG0567	Dehydrogenase, E1 component
HPY04_RS04015	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY04_RS04020	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY04_RS04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY04_RS04035	COG1121	(ABC) transporter
HPY04_RS04040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY04_RS04045	COG4977	sequence-specific DNA binding
HPY04_RS04050	COG1918	ferrous iron import across plasma membrane
HPY04_RS04070	COG0018	arginyl-trna synthetase
HPY04_RS04080	COG1025	Belongs to the peptidase M16 family
HPY04_RS04085	COG2062	phosphohistidine phosphatase, SixA
HPY04_RS04115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY04_RS04120	COG0784	Response regulator, receiver
HPY04_RS04120	COG0643	Histidine kinase
HPY04_RS04120	COG2198	Histidine kinase
HPY04_RS04125	COG2201	protein-glutamate methylesterase activity
HPY04_RS04130	COG1192	Involved in chromosome partitioning
HPY04_RS04140	COG0835	chemotaxis
HPY04_RS04150	COG4133	protoheme IX ABC transporter activity
HPY04_RS04155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY04_RS04160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY04_RS04170	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY04_RS04175	COG1138	Cytochrome C-type biogenesis protein
HPY04_RS04180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY04_RS04185	COG4235	cytochrome complex assembly
HPY04_RS04185	COG3088	subunit of a heme lyase
HPY04_RS04195	COG2853	Lipoprotein
HPY04_RS04215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY04_RS04220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY04_RS04225	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY04_RS04240	COG3083	sulfuric ester hydrolase activity
HPY04_RS04245	COG3082	Protein of unknown function (DUF1414)
HPY04_RS04250	COG3081	Nucleoid-associated protein
HPY04_RS04260	COG1757	Na H antiporter
HPY04_RS04265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY04_RS04270	COG2095	MarC family integral membrane protein
HPY04_RS04275	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_RS04275	COG1454	alcohol dehydrogenase
HPY04_RS04285	COG0659	secondary active sulfate transmembrane transporter activity
HPY04_RS04290	COG1530	ribonuclease E activity
HPY04_RS04295	COG0564	pseudouridine synthase activity
HPY04_RS04300	COG0424	maF-like protein
HPY04_RS04305	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY04_RS04310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY04_RS04315	COG0416	fatty acid biosynthetic process
HPY04_RS04320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY04_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_RS04335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY04_RS04340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY04_RS04345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY04_RS04350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY04_RS04355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY04_RS04365	COG0084	hydrolase, TatD family'
HPY04_RS04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_RS04370	COG1263	PTS System
HPY04_RS04385	COG0733	neurotransmitter:sodium symporter activity
HPY04_RS04400	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY04_RS04410	COG1940	carbohydrate kinase activity
HPY04_RS04415	COG0835	chemotaxis
HPY04_RS04415	COG0784	Response regulator, receiver
HPY04_RS04430	COG2226	methyltransferase
HPY04_RS04440	COG0676	glucose-6-phosphate 1-epimerase activity
HPY04_RS04445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY04_RS04450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_RS04460	COG3139	Protein of unknown function (DUF1315)
HPY04_RS04465	COG0252	asparaginase activity
HPY04_RS04470	COG0616	signal peptide processing
HPY04_RS04475	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY04_RS04475	COG1902	pentaerythritol trinitrate reductase activity
HPY04_RS04480	COG0788	formyltetrahydrofolate deformylase activity
HPY04_RS04490	COG1199	ATP-dependent helicase activity
HPY04_RS04495	COG1214	PFAM Peptidase M22, glycoprotease
HPY04_RS04510	COG0596	Alpha beta hydrolase
HPY04_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
HPY04_RS04520	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY04_RS04535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY04_RS04540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY04_RS04545	COG0436	Aminotransferase
HPY04_RS04550	COG1169	isochorismate synthase
HPY04_RS04555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY04_RS04560	COG0596	Alpha beta hydrolase
HPY04_RS04580	COG3135	benzoate transporter
HPY04_RS04585	COG0477	Major facilitator Superfamily
HPY04_RS04605	COG3015	lipoprotein NlpE involved in copper resistance
HPY04_RS04610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY04_RS04615	COG2894	cell division
HPY04_RS04620	COG0850	regulation of cytokinetic process
HPY04_RS04625	COG3100	YcgL domain-containing protein
HPY04_RS04630	COG2951	lytic endotransglycosylase activity
HPY04_RS04640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY04_RS04645	COG3325	Belongs to the glycosyl hydrolase 18 family
HPY04_RS04645	COG3469	chitinase activity
HPY04_RS04650	COG3005	denitrification pathway
HPY04_RS04655	COG0243	molybdopterin cofactor binding
HPY04_RS04670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_RS04680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY04_RS04715	COG4589	Belongs to the CDS family
HPY04_RS04725	COG5001	Diguanylate cyclase
HPY04_RS04725	COG3300	MHYT domain
HPY04_RS04735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY04_RS04740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY04_RS04745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY04_RS04750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY04_RS04760	COG4191	Histidine kinase
HPY04_RS04770	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY04_RS04780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY04_RS04785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY04_RS04790	COG0776	regulation of translation
HPY04_RS04795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY04_RS04800	COG1555	photosystem II stabilization
HPY04_RS04805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY04_RS04810	COG0539	negative regulation of cytoplasmic translation
HPY04_RS04815	COG0776	regulation of translation
HPY04_RS04820	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY04_RS04825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY04_RS04835	COG0601	transmembrane transport
HPY04_RS04840	COG4239	(ABC) transporter, permease
HPY04_RS04845	COG0747	negative chemotaxis
HPY04_RS04850	COG0444	Belongs to the ABC transporter superfamily
HPY04_RS04855	COG4608	Belongs to the ABC transporter superfamily
HPY04_RS04880	COG0583	DNA-binding transcription factor activity
HPY04_RS04890	COG0686	Belongs to the AlaDH PNT family
HPY04_RS04900	COG1674	ftsk spoiiie
HPY04_RS04905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY04_RS04910	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY04_RS04915	COG2186	Transcriptional regulator
HPY04_RS04930	COG0537	adenosine 5'-monophosphoramidase activity
HPY04_RS04955	COG3150	esterase
HPY04_RS04960	COG1252	NADH dehydrogenase
HPY04_RS04980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY04_RS04990	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY04_RS04995	COG1136	(ABC) transporter
HPY04_RS05000	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY04_RS05010	COG2333	competence protein COMEC
HPY04_RS05010	COG0658	competence protein
HPY04_RS05015	COG1132	(ABC) transporter
HPY04_RS05020	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY04_RS05025	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY04_RS05030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY04_RS05035	COG2719	SpoVR family
HPY04_RS05040	COG2718	Belongs to the UPF0229 family
HPY04_RS05045	COG2766	serine protein kinase
HPY04_RS05050	COG3013	Belongs to the UPF0304 family
HPY04_RS05060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY04_RS05065	COG0840	transmembrane signaling receptor activity
HPY04_RS05075	COG1882	Formate acetyltransferase
HPY04_RS05100	COG4160	amino acid transport
HPY04_RS05105	COG0708	Exodeoxyribonuclease III
HPY04_RS05110	COG0840	transmembrane signaling receptor activity
HPY04_RS05120	COG3923	Primosomal replication protein n
HPY04_RS05125	COG0730	response to heat
HPY04_RS05130	COG1199	ATP-dependent helicase activity
HPY04_RS05135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY04_RS05140	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY04_RS05145	COG3012	SEC-C Motif Domain Protein
HPY04_RS05150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY04_RS05155	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_RS05160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY04_RS05165	COG0215	cysteine-tRNA ligase activity
HPY04_RS05170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY04_RS05175	COG0632	four-way junction helicase activity
HPY04_RS05185	COG1271	oxidase subunit
HPY04_RS05190	COG1294	oxidase, subunit
HPY04_RS05195	COG4890	Cyd operon protein YbgT
HPY04_RS05200	COG3790	cyd operon protein YbgE
HPY04_RS05205	COG0824	Thioesterase
HPY04_RS05210	COG0811	peptide transport
HPY04_RS05225	COG0823	Involved in the tonB-independent uptake of proteins
HPY04_RS05230	COG2885	chlorophyll binding
HPY04_RS05240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY04_RS05250	COG5002	protein histidine kinase activity
HPY04_RS05250	COG0784	Response regulator, receiver
HPY04_RS05260	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_RS05265	COG3284	Transcriptional regulator
HPY04_RS05270	COG4628	conserved protein (DUF2132)
HPY04_RS05280	COG0415	Belongs to the DNA photolyase family
HPY04_RS05295	COG1401	restriction endodeoxyribonuclease activity
HPY04_RS05325	COG4409	exo-alpha-(2->6)-sialidase activity
HPY04_RS05330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY04_RS05335	COG1940	carbohydrate kinase activity
HPY04_RS05345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY04_RS05350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY04_RS05355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY04_RS05360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPY04_RS05365	COG1737	Transcriptional regulator
HPY04_RS05370	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY04_RS05375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY04_RS05385	COG4932	domain protein
HPY04_RS05385	COG5492	domain, Protein
HPY04_RS05410	COG0596	Alpha beta hydrolase
HPY04_RS05420	COG3064	Membrane
HPY04_RS05525	COG4789	Type iii secretion
HPY04_RS05530	COG4792	protein secretion
HPY04_RS05560	COG3710	Transcriptional regulator
HPY04_RS05570	COG4790	Type iii secretion
HPY04_RS05650	COG0582	viral genome integration into host DNA
HPY04_RS05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_RS05675	COG3008	intermembrane lipid transfer
HPY04_RS05675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY04_RS05680	COG2995	paraquat-inducible protein a
HPY04_RS05685	COG0668	transmembrane transport
HPY04_RS05705	COG1309	transcriptional regulator
HPY04_RS05710	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_RS05735	COG1960	acyl-CoA dehydrogenase activity
HPY04_RS05740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY04_RS05745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY04_RS05750	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY04_RS05755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY04_RS05770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY04_RS05775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY04_RS05780	COG0297	glycogen (starch) synthase activity
HPY04_RS05800	COG3070	regulator of competence-specific genes
HPY04_RS05805	COG1609	Transcriptional regulator
HPY04_RS05810	COG3381	protein complex oligomerization
HPY04_RS05815	COG0745	RESPONSE REGULATOR receiver
HPY04_RS05820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY04_RS05825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY04_RS05830	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY04_RS05835	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY04_RS05845	COG1979	alcohol dehydrogenase
HPY04_RS05850	COG2207	Transcriptional regulator
HPY04_RS05870	COG1032	radical SAM domain protein
HPY04_RS05875	COG5001	Diguanylate cyclase
HPY04_RS05880	COG0612	Peptidase, M16
HPY04_RS05895	COG0583	DNA-binding transcription factor activity
HPY04_RS05900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY04_RS05910	COG2350	Protein conserved in bacteria
HPY04_RS05915	COG1607	acyl-coa hydrolase
HPY04_RS05930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY04_RS05935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY04_RS05945	COG2116	formate transmembrane transporter activity
HPY04_RS05950	COG4459	periplasmic nitrate reductase
HPY04_RS05955	COG3005	denitrification pathway
HPY04_RS05960	COG0243	molybdopterin cofactor binding
HPY04_RS05975	COG1227	inorganic diphosphatase activity
HPY04_RS05990	COG4172	Belongs to the ABC transporter superfamily
HPY04_RS06005	COG4168	peptide transport system, permease
HPY04_RS06015	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY04_RS06020	COG1842	Phage shock protein A
HPY04_RS06035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_RS06050	COG2818	Glycosylase
HPY04_RS06055	COG0626	cystathionine gamma-synthase activity
HPY04_RS06065	COG0733	neurotransmitter:sodium symporter activity
HPY04_RS06070	COG0564	pseudouridine synthase activity
HPY04_RS06075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY04_RS06080	COG4136	ATPase activity
HPY04_RS06085	COG4135	transport system, permease component
HPY04_RS06090	COG4134	Bacterial extracellular solute-binding protein
HPY04_RS06100	COG3313	Fe-S protein
HPY04_RS06110	COG0842	Transport permease protein
HPY04_RS06115	COG1131	(ABC) transporter
HPY04_RS06120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_RS06125	COG0814	amino acid
HPY04_RS06135	COG2239	Acts as a magnesium transporter
HPY04_RS06140	COG0784	Response regulator, receiver
HPY04_RS06140	COG2205	protein histidine kinase activity
HPY04_RS06155	COG4934	collagen metabolic process
HPY04_RS06190	COG0840	transmembrane signaling receptor activity
HPY04_RS06200	COG3706	GGDEF domain
HPY04_RS06200	COG2203	Gaf domain
HPY04_RS06200	COG4251	negative regulation of phosphorylation
HPY04_RS06200	COG5001	Diguanylate cyclase
HPY04_RS06205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY04_RS06210	COG5002	protein histidine kinase activity
HPY04_RS06225	COG1061	Type III restriction enzyme res subunit
HPY04_RS06230	COG1187	pseudouridine synthase activity
HPY04_RS06235	COG2814	Major facilitator Superfamily
HPY04_RS06245	COG0702	epimerase
HPY04_RS06250	COG0534	Mate efflux family protein
HPY04_RS06255	COG4181	ATPase activity
HPY04_RS06270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY04_RS06280	COG1748	Saccharopine dehydrogenase
HPY04_RS06295	COG1538	Outer membrane efflux protein
HPY04_RS06315	COG0583	DNA-binding transcription factor activity
HPY04_RS06325	COG1451	nucleotide metabolic process
HPY04_RS06340	COG3063	Type IV pilus biogenesis stability protein PilW
HPY04_RS06345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY04_RS06365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_RS06380	COG3290	protein histidine kinase activity
HPY04_RS06385	COG4565	transcriptional regulatory protein
HPY04_RS06395	COG0835	chemotaxis
HPY04_RS06395	COG0784	Response regulator, receiver
HPY04_RS06440	COG1085	galactose-1-phosphate uridylyltransferase
HPY04_RS06445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY04_RS06450	COG2017	converts alpha-aldose to the beta-anomer
HPY04_RS06455	COG3706	GGDEF domain
HPY04_RS06460	COG2200	EAL domain
HPY04_RS06460	COG2199	diguanylate cyclase activity
HPY04_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_RS06475	COG3527	Alpha-acetolactate decarboxylase
HPY04_RS06490	COG0753	catalase activity
HPY04_RS06510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY04_RS06560	COG1271	oxidase subunit
HPY04_RS06565	COG1294	oxidase, subunit
HPY04_RS06570	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY04_RS06570	COG1136	(ABC) transporter
HPY04_RS06575	COG0577	efflux transmembrane transporter activity
HPY04_RS06575	COG1136	(ABC) transporter
HPY04_RS06580	COG1136	(ABC) transporter
HPY04_RS06580	COG0577	efflux transmembrane transporter activity
HPY04_RS06605	COG2723	6-phospho-beta-galactosidase activity
HPY04_RS06610	COG1609	Transcriptional regulator
HPY04_RS06615	COG0251	oxidation-reduction process
HPY04_RS06620	COG2731	YhcH YjgK YiaL family protein
HPY04_RS06625	COG0584	glycerophosphoryl diester phosphodiesterase
HPY04_RS06630	COG1349	DNA-binding transcription factor activity
HPY04_RS06635	COG3842	ATPase activity
HPY04_RS06640	COG0395	ABC-type sugar transport system, permease component
HPY04_RS06645	COG1175	transmembrane transport
HPY04_RS06660	COG0811	peptide transport
HPY04_RS06665	COG0811	peptide transport
HPY04_RS06670	COG0848	biopolymer transport protein
HPY04_RS06675	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY04_RS06685	COG1793	dna ligase
HPY04_RS06695	COG0534	Mate efflux family protein
HPY04_RS06705	COG3001	Fructosamine kinase
HPY04_RS06715	COG0791	NLP P60 protein
HPY04_RS06720	COG0840	transmembrane signaling receptor activity
HPY04_RS06735	COG1940	carbohydrate kinase activity
HPY04_RS06750	COG0746	molybdenum cofactor guanylyltransferase activity
HPY04_RS06755	COG3842	ATPase activity
HPY04_RS06760	COG4662	Binding-protein-dependent transport system inner membrane component
HPY04_RS06770	COG2204	response regulator
HPY04_RS06775	COG3852	Histidine kinase
HPY04_RS06780	COG0488	(ABC) transporter
HPY04_RS06785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY04_RS06815	COG3383	formate dehydrogenase (NAD+) activity
HPY04_RS06815	COG0243	molybdopterin cofactor binding
HPY04_RS06820	COG0437	4 iron, 4 sulfur cluster binding
HPY04_RS06835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY04_RS06840	COG1666	GTP binding
HPY04_RS06845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY04_RS06860	COG2996	Protein conserved in bacteria
HPY04_RS06870	COG3008	intermembrane lipid transfer
HPY04_RS06875	COG2995	paraquat-inducible protein a
HPY04_RS06880	COG1132	(ABC) transporter
HPY04_RS06885	COG1956	GAF domain-containing protein
HPY04_RS06890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY04_RS06905	COG0308	aminopeptidase N
HPY04_RS06920	COG0167	dihydroorotate dehydrogenase activity
HPY04_RS06930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY04_RS06930	COG0116	Belongs to the methyltransferase superfamily
HPY04_RS06955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY04_RS06960	COG1067	ATP-dependent peptidase activity
HPY04_RS06965	COG3120	sequence-specific DNA binding
HPY04_RS07060	COG1073	alpha beta
HPY04_RS07060	COG3064	Membrane
HPY04_RS07060	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY04_RS07065	COG2994	toxin metabolic process
HPY04_RS07090	COG2205	protein histidine kinase activity
HPY04_RS07090	COG0784	Response regulator, receiver
HPY04_RS07105	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY04_RS07120	COG2010	Cytochrome c
HPY04_RS07130	COG2217	Heavy metal translocating P-type atpase
HPY04_RS07145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY04_RS07150	COG0589	response to stress
HPY04_RS07155	COG0037	tRNA processing
HPY04_RS07175	COG3842	ATPase activity
HPY04_RS07185	COG1177	transmembrane transport
HPY04_RS07195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY04_RS07210	COG1115	amino acid carrier protein
HPY04_RS07215	COG1280	lysine exporter protein (LysE YggA)
HPY04_RS07260	COG3501	Rhs element vgr protein
HPY04_RS07270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY04_RS07275	COG0840	transmembrane signaling receptor activity
HPY04_RS07280	COG2814	Major facilitator Superfamily
HPY04_RS07285	COG1566	PFAM secretion protein HlyD family protein
HPY04_RS07290	COG1538	Outer membrane efflux protein
HPY04_RS07305	COG0513	Belongs to the DEAD box helicase family
HPY04_RS07325	COG3290	protein histidine kinase activity
HPY04_RS07325	COG0840	transmembrane signaling receptor activity
HPY04_RS07330	COG0835	chemotaxis
HPY04_RS07335	COG2201	protein-glutamate methylesterase activity
HPY04_RS07345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY04_RS07350	COG0784	Response regulator, receiver
HPY04_RS07350	COG2198	Histidine kinase
HPY04_RS07350	COG0643	Histidine kinase
HPY04_RS07355	COG0643	Histidine kinase
HPY04_RS07355	COG2198	Histidine kinase
HPY04_RS07365	COG0745	RESPONSE REGULATOR receiver
HPY04_RS07380	COG0415	Belongs to the DNA photolyase family
HPY04_RS07385	COG0477	Major facilitator Superfamily
HPY04_RS07390	COG0583	DNA-binding transcription factor activity
HPY04_RS07400	COG0402	S-adenosylhomocysteine deaminase activity
HPY04_RS07405	COG0095	Lipoate-protein ligase
HPY04_RS07410	COG0443	Heat shock 70 kDa protein
HPY04_RS07420	COG1643	Atp-dependent helicase
HPY04_RS07450	COG0443	Heat shock 70 kDa protein
HPY04_RS07455	COG0443	Heat shock 70 kDa protein
HPY04_RS07460	COG3706	GGDEF domain
HPY04_RS07490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY04_RS07495	COG0602	queuosine metabolic process
HPY04_RS07500	COG0561	phosphatase activity
HPY04_RS07510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_RS07515	COG4597	amino acid ABC transporter
HPY04_RS07520	COG0765	amino acid transport
HPY04_RS07525	COG1126	abc transporter atp-binding protein
HPY04_RS07530	COG0670	Belongs to the BI1 family
HPY04_RS07535	COG2920	part of a sulfur-relay system
HPY04_RS07540	COG1254	Belongs to the acylphosphatase family
HPY04_RS07545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY04_RS07550	COG3706	GGDEF domain
HPY04_RS07560	COG4999	Histidine kinase
HPY04_RS07560	COG2205	protein histidine kinase activity
HPY04_RS07560	COG3850	Histidine kinase
HPY04_RS07560	COG3437	response regulator, receiver
HPY04_RS07565	COG3437	response regulator, receiver
HPY04_RS07570	COG0625	glutathione transferase activity
HPY04_RS07580	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY04_RS07590	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY04_RS07605	COG3385	transposase activity
HPY04_RS07625	COG0372	Belongs to the citrate synthase family
HPY04_RS07630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY04_RS07670	COG1129	ABC transporter
HPY04_RS07695	COG0745	RESPONSE REGULATOR receiver
HPY04_RS07700	COG5002	protein histidine kinase activity
HPY04_RS07705	COG3713	MltA-interacting MipA family protein
HPY04_RS07710	COG2990	Protein conserved in bacteria
HPY04_RS07720	COG4191	Histidine kinase
HPY04_RS07720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_RS07725	COG0471	metal ion transport
HPY04_RS07735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY04_RS07750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_RS07760	COG3768	UPF0283 membrane protein
HPY04_RS07765	COG3106	COG3106 Predicted ATPase
HPY04_RS07780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY04_RS07785	COG0494	nUDIX hydrolase
HPY04_RS07790	COG0814	amino acid
HPY04_RS07795	COG1760	l-serine dehydratase
HPY04_RS07800	COG0720	synthase
HPY04_RS07805	COG0840	transmembrane signaling receptor activity
HPY04_RS07810	COG0017	Asparaginyl-tRNA synthetase
HPY04_RS07815	COG0351	phosphomethylpyrimidine kinase
HPY04_RS07820	COG3437	response regulator, receiver
HPY04_RS07820	COG2770	Histidine kinase
HPY04_RS07825	COG1448	Aminotransferase
HPY04_RS07840	COG0840	transmembrane signaling receptor activity
HPY04_RS07845	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY04_RS07850	COG2943	transferase activity, transferring hexosyl groups
HPY04_RS07855	COG1609	Transcriptional regulator
HPY04_RS07860	COG3394	polysaccharide catabolic process
HPY04_RS07865	COG1486	melibiose metabolic process
HPY04_RS07870	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPY04_RS07880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPY04_RS07885	COG0726	polysaccharide deacetylase
HPY04_RS07890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY04_RS07895	COG1846	Transcriptional regulator
HPY04_RS07920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY04_RS07935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY04_RS07940	COG3108	Peptidase M15
HPY04_RS07970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY04_RS07980	COG2814	Major facilitator Superfamily
HPY04_RS08000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY04_RS08005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY04_RS08010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY04_RS08055	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY04_RS08060	COG4139	cobalamin transport
HPY04_RS08065	COG2988	succinylglutamate desuccinylase activity
HPY04_RS08080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY04_RS08085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY04_RS08090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_RS08100	COG2925	Exonuclease
HPY04_RS08105	COG1380	Effector of murein hydrolase LrgA
HPY04_RS08110	COG1346	cytolysis
HPY04_RS08140	COG0776	regulation of translation
HPY04_RS08145	COG0072	phenylalanine-tRNA ligase activity
HPY04_RS08145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_RS08150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY04_RS08190	COG0322	excinuclease ABC activity
HPY04_RS08195	COG2197	response regulator
HPY04_RS08200	COG0417	DNA replication proofreading
HPY04_RS08205	COG5001	Diguanylate cyclase
HPY04_RS08215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY04_RS08220	COG3099	Belongs to the UPF0263 family
HPY04_RS08235	COG1228	amidohydrolase
HPY04_RS08240	COG0010	Belongs to the arginase family
HPY04_RS08245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY04_RS08250	COG2986	histidine ammonia-lyase
HPY04_RS08270	COG0247	lactate metabolic process
HPY04_RS08270	COG0277	FAD linked oxidase domain protein
HPY04_RS08285	COG2885	chlorophyll binding
HPY04_RS08305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY04_RS08315	COG0281	malic enzyme
HPY04_RS08325	COG2949	membrane
HPY04_RS08330	COG3706	GGDEF domain
HPY04_RS08335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY04_RS08345	COG0492	ferredoxin-NADP+ reductase activity
HPY04_RS08350	COG4988	ABC transporter
HPY04_RS08355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY04_RS08360	COG1187	pseudouridine synthase activity
HPY04_RS08365	COG0009	L-threonylcarbamoyladenylate synthase
HPY04_RS08370	COG0613	PHP domain protein
HPY04_RS08380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY04_RS08385	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY04_RS08390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY04_RS08395	COG0134	indole-3-glycerol-phosphate synthase activity
HPY04_RS08395	COG0135	phosphoribosylanthranilate isomerase activity
HPY04_RS08400	COG0133	tryptophan synthase activity
HPY04_RS08405	COG0159	tryptophan synthase activity
HPY04_RS08415	COG1435	thymidine kinase activity
HPY04_RS08420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY04_RS08425	COG1801	Protein of unknown function DUF72
HPY04_RS08430	COG4106	trans-aconitate 2-methyltransferase activity
HPY04_RS08435	COG0500	methyltransferase
HPY04_RS08440	COG4067	protein conserved in archaea
HPY04_RS08440	COG0189	ligase activity
HPY04_RS08455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY04_RS08465	COG3852	Histidine kinase
HPY04_RS08480	COG3070	regulator of competence-specific genes
HPY04_RS08490	COG2431	L-lysine efflux transmembrane transporter activity
HPY04_RS08500	COG0076	glutamate decarboxylase activity
HPY04_RS08505	COG1737	Transcriptional regulator
HPY04_RS08510	COG1012	belongs to the aldehyde dehydrogenase family
HPY04_RS08510	COG1454	alcohol dehydrogenase
HPY04_RS08515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY04_RS08520	COG3273	potassium ion transport
HPY04_RS08520	COG2985	domain, Protein
HPY04_RS08525	COG0542	response to heat
HPY04_RS08530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY04_RS08535	COG1278	Cold shock
HPY04_RS08545	COG1187	pseudouridine synthase activity
HPY04_RS08550	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY04_RS08550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY04_RS08555	COG0107	imidazoleglycerol-phosphate synthase activity
HPY04_RS08560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY04_RS08565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY04_RS08570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY04_RS08570	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY04_RS08575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY04_RS08580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY04_RS08585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY04_RS08590	COG1757	Na H antiporter
HPY04_RS08595	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY04_RS08600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_RS08605	COG0482	sulfurtransferase activity
HPY04_RS08610	COG2915	High frequency lysogenization protein hflD homolog
HPY04_RS08615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY04_RS08625	COG2268	Band 7 protein
HPY04_RS08635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY04_RS08650	COG0300	oxidoreductase activity
HPY04_RS08660	COG0501	Belongs to the peptidase M48B family
HPY04_RS08670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY04_RS08675	COG2226	methyltransferase
HPY04_RS08680	COG0156	8-amino-7-oxononanoate synthase activity
HPY04_RS08685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY04_RS08690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY04_RS08695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY04_RS08700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY04_RS08705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY04_RS08710	COG0653	protein targeting
HPY04_RS08715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY04_RS08720	COG2199	diguanylate cyclase activity
HPY04_RS08720	COG2203	Gaf domain
HPY04_RS08730	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY04_RS08740	COG4628	conserved protein (DUF2132)
HPY04_RS08745	COG3092	negative regulation of chromosome organization
HPY04_RS08750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY04_RS08755	COG0857	belongs to the CobB CobQ family
HPY04_RS08755	COG0280	phosphate acetyltransferase
HPY04_RS08760	COG0435	Glutathione S-transferase
HPY04_RS08765	COG4608	Belongs to the ABC transporter superfamily
HPY04_RS08770	COG0444	Belongs to the ABC transporter superfamily
HPY04_RS08775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_RS08780	COG0601	transmembrane transport
HPY04_RS08800	COG2204	response regulator
HPY04_RS08805	COG3300	MHYT domain
HPY04_RS08805	COG5001	Diguanylate cyclase
HPY04_RS08810	COG4191	Histidine kinase
HPY04_RS08815	COG5002	protein histidine kinase activity
HPY04_RS08825	COG2201	protein-glutamate methylesterase activity
HPY04_RS08840	COG0009	L-threonylcarbamoyladenylate synthase
HPY04_RS08855	COG1881	PFAM PEBP family protein
HPY04_RS08880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY04_RS08885	COG0640	Transcriptional regulator
HPY04_RS08895	COG0454	-acetyltransferase
HPY04_RS08905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY04_RS08910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_RS08920	COG5002	protein histidine kinase activity
HPY04_RS08930	COG3706	GGDEF domain
HPY04_RS08950	COG1946	Acyl-CoA thioesterase
HPY04_RS08955	COG1522	sequence-specific DNA binding
HPY04_RS08965	COG0616	signal peptide processing
HPY04_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_RS08975	COG2983	Belongs to the UPF0260 family
HPY04_RS08985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY04_RS08990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY04_RS08995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY04_RS09000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY04_RS09005	COG2832	Protein of unknown function (DUF454)
HPY04_RS09010	COG0745	RESPONSE REGULATOR receiver
HPY04_RS09015	COG0583	DNA-binding transcription factor activity
HPY04_RS09020	COG0778	Nitroreductase
HPY04_RS09025	COG1024	Enoyl-CoA hydratase
HPY04_RS09025	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY04_RS09030	COG0183	Belongs to the thiolase family
HPY04_RS09045	COG2067	long-chain fatty acid transport protein
HPY04_RS09055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY04_RS09060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY04_RS09065	COG2982	Protein involved in outer membrane biogenesis
HPY04_RS09070	COG0572	uridine kinase
HPY04_RS09075	COG0489	protein tyrosine kinase activity
HPY04_RS09080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_RS09080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY04_RS09090	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY04_RS09100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY04_RS09100	COG0517	IMP dehydrogenase activity
HPY04_RS09100	COG0617	tRNA 3'-terminal CCA addition
HPY04_RS09105	COG2199	diguanylate cyclase activity
HPY04_RS09110	COG0314	molybdopterin synthase activity
HPY04_RS09115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY04_RS09120	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY04_RS09125	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY04_RS09130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY04_RS09135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY04_RS09140	COG2198	Histidine kinase
HPY04_RS09145	COG2204	response regulator
HPY04_RS09150	COG0556	nucleotide-excision repair
HPY04_RS09160	COG4657	Part of a membrane complex involved in electron transport
HPY04_RS09165	COG2878	Part of a membrane complex involved in electron transport
HPY04_RS09170	COG4656	Part of a membrane complex involved in electron transport
HPY04_RS09185	COG4660	Part of a membrane complex involved in electron transport
HPY04_RS09190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY04_RS09195	COG0346	lactoylglutathione lyase activity
HPY04_RS09210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY04_RS09215	COG2056	Na+-H+ antiporter family
HPY04_RS09220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY04_RS09225	COG1286	toxin biosynthetic process
HPY04_RS09230	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY04_RS09235	COG0285	dihydrofolate synthase activity
HPY04_RS09240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY04_RS09245	COG0101	tRNA pseudouridine synthase activity
HPY04_RS09260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_RS09260	COG1263	PTS System
HPY04_RS09260	COG2190	(PTS) system
HPY04_RS09265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY04_RS09270	COG1846	Transcriptional regulator
HPY04_RS09270	COG1940	carbohydrate kinase activity
HPY04_RS09275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY04_RS09275	COG4651	solute:proton antiporter activity
HPY04_RS09280	COG0367	asparagine synthase
HPY04_RS09290	COG3104	oligopeptide transport
HPY04_RS09295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY04_RS09300	COG0563	adenylate kinase activity
HPY04_RS09305	COG0326	Molecular chaperone. Has ATPase activity
HPY04_RS09310	COG3710	Transcriptional regulator
HPY04_RS09325	COG0622	Phosphoesterase
HPY04_RS09330	COG1090	epimerase
HPY04_RS09335	COG0300	oxidoreductase activity
HPY04_RS09340	COG3118	belongs to the thioredoxin family
HPY04_RS09345	COG0330	HflC and HflK could
HPY04_RS09350	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY04_RS09355	COG0789	Transcriptional regulator
HPY04_RS09360	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY04_RS09370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY04_RS09375	COG3115	cell septum assembly
HPY04_RS09380	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY04_RS09385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY04_RS09390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_RS09400	COG2190	(PTS) system
HPY04_RS09405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY04_RS09410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY04_RS09415	COG1702	phosphate starvation-inducible protein PhoH
HPY04_RS09420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY04_RS09425	COG4535	Mg2 and Co2 transporter CorC
HPY04_RS09430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY04_RS09435	COG2888	peptidyl-tyrosine sulfation
HPY04_RS09440	COG0495	leucyl-tRNA aminoacylation
HPY04_RS09445	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY04_RS09450	COG1466	dna polymerase III delta subunit
HPY04_RS09455	COG0799	negative regulation of ribosome biogenesis
HPY04_RS09460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY04_RS09465	COG0768	penicillin binding
HPY04_RS09470	COG0772	Belongs to the SEDS family
HPY04_RS09475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY04_RS09480	COG1686	Belongs to the peptidase S11 family
HPY04_RS09485	COG2921	Belongs to the UPF0250 family
HPY04_RS09490	COG0321	lipoyl(octanoyl) transferase activity
HPY04_RS09495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY04_RS09505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY04_RS09530	COG1596	polysaccharide export
HPY04_RS09540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY04_RS09570	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY04_RS09580	COG0438	transferase activity, transferring glycosyl groups
HPY04_RS09590	COG0297	glycogen (starch) synthase activity
HPY04_RS09610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY04_RS09615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY04_RS09620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY04_RS09625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY04_RS09655	COG0366	Alpha amylase catalytic
HPY04_RS09660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_RS09660	COG1263	PTS System
HPY04_RS09665	COG1609	Transcriptional regulator
HPY04_RS09670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY04_RS09675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY04_RS09680	COG2011	ABC-type metal ion transport system permease component
HPY04_RS09685	COG1464	Belongs to the NlpA lipoprotein family
HPY04_RS09690	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY04_RS09700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY04_RS09700	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY04_RS09710	COG3706	GGDEF domain
HPY04_RS09715	COG1611	Belongs to the LOG family
HPY04_RS09720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY04_RS09725	COG2363	Small membrane protein
HPY04_RS09730	COG0583	DNA-binding transcription factor activity
HPY04_RS09735	COG0301	tRNA thio-modification
HPY04_RS09735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY04_RS09745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY04_RS09750	COG1722	exodeoxyribonuclease VII activity
HPY04_RS09755	COG0142	geranyltranstransferase activity
HPY04_RS09760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY04_RS09765	COG0564	pseudouridine synthase activity
HPY04_RS09770	COG3098	single-species biofilm formation
HPY04_RS09785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_RS09795	COG1671	Belongs to the UPF0178 family
HPY04_RS09800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY04_RS09805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY04_RS09810	COG0254	rRNA binding
HPY04_RS09815	COG1720	tRNA m6t6A37 methyltransferase activity
HPY04_RS09820	COG0442	prolyl-tRNA aminoacylation
HPY04_RS09845	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY04_RS09845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY04_RS09850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY04_RS09860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY04_RS09890	COG0484	heat shock protein binding
HPY04_RS09895	COG0443	Heat shock 70 kDa protein
HPY04_RS09900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY04_RS09905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY04_RS09910	COG0497	DNA recombination
HPY04_RS09915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_RS09920	COG2914	Belongs to the UPF0125 (RnfH) family
HPY04_RS09925	COG2867	negative regulation of translational initiation
HPY04_RS09930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY04_RS09940	COG0582	viral genome integration into host DNA
HPY04_RS09985	COG0732	type I restriction modification DNA specificity domain
HPY04_RS10025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY04_RS10090	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY04_RS10095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY04_RS10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY04_RS10120	COG3051	citrate lyase alpha subunit
HPY04_RS10125	COG2301	Belongs to the HpcH HpaI aldolase family
HPY04_RS10130	COG3052	prosthetic group binding
HPY04_RS10135	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY04_RS10145	COG3630	sodium ion export across plasma membrane
HPY04_RS10150	COG5016	pyruvate
HPY04_RS10150	COG0511	ligase activity, forming carbon-carbon bonds
HPY04_RS10155	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY04_RS10165	COG4565	transcriptional regulatory protein
HPY04_RS10180	COG0583	DNA-binding transcription factor activity
HPY04_RS10190	COG1115	amino acid carrier protein
HPY04_RS10195	COG2977	Belongs to the P-Pant transferase superfamily
HPY04_RS10200	COG1120	ATPase activity
HPY04_RS10205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_RS10210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_RS10215	COG4592	Periplasmic binding protein
HPY04_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_RS10230	COG1169	isochorismate synthase
HPY04_RS10235	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY04_RS10240	COG3433	isochorismatase activity
HPY04_RS10240	COG1535	isochorismatase
HPY04_RS10245	COG1584	GPR1 FUN34 yaaH family protein
HPY04_RS10255	COG0519	Catalyzes the synthesis of GMP from XMP
HPY04_RS10255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY04_RS10260	COG0516	GMP reductase activity
HPY04_RS10260	COG0517	IMP dehydrogenase activity
HPY04_RS10265	COG1570	exodeoxyribonuclease VII activity
HPY04_RS10280	COG1160	GTP binding
HPY04_RS10285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_RS10290	COG2976	Protein conserved in bacteria
HPY04_RS10295	COG0124	histidyl-tRNA synthetase
HPY04_RS10300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY04_RS10315	COG0105	UTP biosynthetic process
HPY04_RS10320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY04_RS10325	COG2975	iron-sulfur cluster assembly
HPY04_RS10330	COG0633	Ferredoxin
HPY04_RS10350	COG0822	iron-sulfur transferase activity
HPY04_RS10360	COG1959	2 iron, 2 sulfur cluster binding
HPY04_RS10370	COG0483	inositol monophosphate 1-phosphatase activity
HPY04_RS10375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_RS10380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_RS10385	COG1862	Preprotein translocase
HPY04_RS10400	COG0517	IMP dehydrogenase activity
HPY04_RS10410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY04_RS10415	COG0583	DNA-binding transcription factor activity
HPY04_RS10420	COG0450	alkyl hydroperoxide reductase
HPY04_RS10425	COG3142	Participates in the control of copper homeostasis
HPY04_RS10440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY04_RS10445	COG0581	inorganic phosphate transmembrane transporter activity
HPY04_RS10455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY04_RS10460	COG0248	Ppx GppA phosphatase
HPY04_RS10470	COG5002	protein histidine kinase activity
HPY04_RS10475	COG0745	RESPONSE REGULATOR receiver
HPY04_RS10490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY04_RS10535	COG0542	response to heat
HPY04_RS10545	COG0564	pseudouridine synthase activity
HPY04_RS10550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_RS10555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY04_RS10560	COG1605	Chorismate mutase
HPY04_RS10560	COG0077	Prephenate dehydratase
HPY04_RS10565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY04_RS10570	COG5001	Diguanylate cyclase
HPY04_RS10580	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY04_RS10590	COG0488	(ABC) transporter
HPY04_RS10600	COG1605	Chorismate mutase
HPY04_RS10600	COG0287	Prephenate dehydrogenase
HPY04_RS10605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY04_RS10610	COG3275	phosphorelay sensor kinase activity
HPY04_RS10615	COG3279	Response regulator of the LytR AlgR family
HPY04_RS10625	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY04_RS10630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY04_RS10640	COG1966	Carbon starvation protein
HPY04_RS10645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY04_RS10650	COG1047	Peptidyl-prolyl cis-trans
HPY04_RS10655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY04_RS10665	COG0196	riboflavin kinase activity
HPY04_RS10670	COG0728	peptidoglycan biosynthetic process
HPY04_RS10675	COG0268	Binds directly to 16S ribosomal RNA
HPY04_RS10680	COG0640	Transcriptional regulator
HPY04_RS10685	COG0583	DNA-binding transcription factor activity
HPY04_RS10690	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY04_RS10700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY04_RS10705	COG0730	response to heat
HPY04_RS10710	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY04_RS10715	COG0494	nUDIX hydrolase
HPY04_RS10720	COG3066	DNA modification
HPY04_RS10725	COG0667	Aldo Keto reductase
HPY04_RS10735	COG2204	response regulator
HPY04_RS10740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY04_RS10760	COG0513	Belongs to the DEAD box helicase family
HPY04_RS10785	COG3153	acetyltransferase
HPY04_RS10790	COG3154	lipid carrier protein
HPY04_RS10800	COG0826	peptidase U32
HPY04_RS10805	COG0826	peptidase U32
HPY04_RS10825	COG1185	polyribonucleotide nucleotidyltransferase activity
HPY04_RS10830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY04_RS10840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY04_RS10845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY04_RS10850	COG0195	Participates in both transcription termination and antitermination
HPY04_RS10855	COG0779	Required for maturation of 30S ribosomal subunits
HPY04_RS10870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY04_RS10880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY04_RS10885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY04_RS10890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY04_RS10895	COG1534	Rna-binding protein
HPY04_RS10900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY04_RS10905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY04_RS10910	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY04_RS10915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY04_RS10920	COG0739	heme binding
HPY04_RS10935	COG0316	Belongs to the HesB IscA family
HPY04_RS10940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY04_RS10945	COG0628	permease
HPY04_RS10950	COG2813	Specifically methylates the guanine in position
HPY04_RS10955	COG2205	protein histidine kinase activity
HPY04_RS10955	COG0784	Response regulator, receiver
HPY04_RS10960	COG0747	negative chemotaxis
HPY04_RS10965	COG0601	transmembrane transport
HPY04_RS10970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_RS10975	COG0444	Belongs to the ABC transporter superfamily
HPY04_RS10980	COG4608	Belongs to the ABC transporter superfamily
HPY04_RS10990	COG2971	BadF BadG BcrA BcrD
HPY04_RS11010	COG3842	ATPase activity
HPY04_RS11020	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY04_RS11025	COG0004	ammonium transporteR
HPY04_RS11030	COG0347	Belongs to the P(II) protein family
HPY04_RS11035	COG3112	Uncharacterised protein family (UPF0231)
HPY04_RS11040	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY04_RS11045	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY04_RS11050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY04_RS11055	COG1643	Atp-dependent helicase
HPY04_RS11065	COG1489	DNA binding
HPY04_RS11075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY04_RS11085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY04_RS11090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY04_RS11095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY04_RS11100	COG0842	Transport permease protein
HPY04_RS11105	COG1131	(ABC) transporter
HPY04_RS11110	COG0659	secondary active sulfate transmembrane transporter activity
HPY04_RS11115	COG0288	reversible hydration of carbon dioxide
HPY04_RS11130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY04_RS11135	COG3107	peptidoglycan biosynthetic process
HPY04_RS11140	COG0792	nuclease activity
HPY04_RS11145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY04_RS11150	COG2823	Periplasmic or secreted lipoprotein
HPY04_RS11155	COG2969	positive regulation of protein catabolic process
HPY04_RS11160	COG0625	glutathione transferase activity
HPY04_RS11165	COG2857	Cytochrome c1
HPY04_RS11170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY04_RS11175	COG0723	plastoquinol--plastocyanin reductase activity
HPY04_RS11180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY04_RS11185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY04_RS11190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY04_RS11200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY04_RS11205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY04_RS11210	COG0335	large ribosomal subunit rRNA binding
HPY04_RS11215	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY04_RS11220	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY04_RS11225	COG0228	four-way junction DNA binding
HPY04_RS11230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY04_RS11235	COG4137	Cytochrome C assembly protein
HPY04_RS11240	COG4536	flavin adenine dinucleotide binding
HPY04_RS11245	COG1854	S-ribosylhomocysteine lyase activity
HPY04_RS11250	COG2918	glutathione biosynthetic process
HPY04_RS11255	COG0612	Peptidase, M16
HPY04_RS11260	COG1238	metal cluster binding
HPY04_RS11270	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY04_RS11275	COG5016	pyruvate
HPY04_RS11275	COG0511	ligase activity, forming carbon-carbon bonds
HPY04_RS11280	COG3630	sodium ion export across plasma membrane
HPY04_RS11325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY04_RS11330	COG0527	aspartate kinase activity
HPY04_RS11335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY04_RS11340	COG2137	regulation of response to DNA damage stimulus
HPY04_RS11345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY04_RS11355	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY04_RS11360	COG4208	sulfate ABC transporter
HPY04_RS11380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY04_RS11385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY04_RS11395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY04_RS11400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY04_RS11405	COG0585	pseudouridine synthase activity
HPY04_RS11410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY04_RS11415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY04_RS11420	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY04_RS11425	COG1968	undecaprenyl-diphosphatase activity
HPY04_RS11430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY04_RS11435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY04_RS11440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY04_RS11450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY04_RS11455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY04_RS11460	COG1610	YqeY-like protein
HPY04_RS11465	COG0358	DNA primase activity
HPY04_RS11485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY04_RS11490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY04_RS11495	COG1349	DNA-binding transcription factor activity
HPY04_RS11515	COG1279	arginine transmembrane transporter activity
HPY04_RS11520	COG0668	transmembrane transport
HPY04_RS11525	COG0191	fructose-bisphosphate aldolase activity
HPY04_RS11530	COG0126	phosphoglycerate kinase activity
HPY04_RS11535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY04_RS11540	COG4771	TonB-dependent receptor
HPY04_RS11545	COG0583	DNA-binding transcription factor activity
HPY04_RS11550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY04_RS11555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY04_RS11565	COG2356	endonuclease I
HPY04_RS11570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY04_RS11575	COG0189	ligase activity
HPY04_RS11580	COG1678	Uncharacterized ACR, COG1678
HPY04_RS11585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY04_RS11590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY04_RS11610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY04_RS11615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY04_RS11620	COG0762	integral membrane protein
HPY04_RS11635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY04_RS11640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY04_RS11645	COG2066	Belongs to the glutaminase family
HPY04_RS11650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY04_RS11655	COG1194	a g-specific adenine glycosylase
HPY04_RS11660	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY04_RS11665	COG0741	lytic transglycosylase activity
HPY04_RS11720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY04_RS11725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY04_RS11730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY04_RS11735	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY04_RS11740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY04_RS11745	COG2967	ApaG domain
HPY04_RS11750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY04_RS11760	COG3610	response to peptide
HPY04_RS11765	COG2966	Psort location CytoplasmicMembrane, score
HPY04_RS11770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY04_RS11775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY04_RS11780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY04_RS11785	COG0142	geranyltranstransferase activity
HPY04_RS11790	COG0531	amino acid
HPY04_RS11795	COG0039	L-malate dehydrogenase activity
HPY04_RS11800	COG1438	arginine binding
HPY04_RS11805	COG2358	TRAP transporter, solute receptor (TAXI family
HPY04_RS11815	COG0589	response to stress
HPY04_RS11835	COG2235	arginine
HPY04_RS11840	COG0312	modulator of DNA gyrase
HPY04_RS11845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY04_RS11850	COG3164	Protein of unknown function
HPY04_RS11855	COG1530	ribonuclease E activity
HPY04_RS11860	COG0424	maF-like protein
HPY04_RS11865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY04_RS11870	COG1792	Involved in formation and maintenance of cell shape
HPY04_RS11875	COG1077	Cell shape determining protein MreB Mrl
HPY04_RS11920	COG1459	type II secretion system
HPY04_RS11925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY04_RS11935	COG3409	Peptidoglycan-binding domain 1 protein
HPY04_RS11935	COG3267	Type II secretory pathway component ExeA
HPY04_RS11960	COG2199	diguanylate cyclase activity
HPY04_RS11960	COG2200	EAL domain
HPY04_RS11970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY04_RS11975	COG0732	type I restriction modification DNA specificity domain
HPY04_RS12015	COG0629	single-stranded DNA binding
HPY04_RS12030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY04_RS12045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY04_RS12050	COG0527	aspartate kinase activity
HPY04_RS12055	COG0646	methionine synthase
HPY04_RS12055	COG1410	methionine synthase
HPY04_RS12120	COG0175	sulfate reduction
HPY04_RS12130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY04_RS12155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY04_RS12160	COG0735	belongs to the Fur family
HPY04_RS12175	COG0166	Belongs to the GPI family
HPY04_RS12185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY04_RS12200	COG0359	binds to the 23S rRNA
HPY04_RS12205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY04_RS12210	COG2965	DNA replication, synthesis of RNA primer
HPY04_RS12215	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY04_RS12225	COG2906	2 iron, 2 sulfur cluster binding
HPY04_RS12230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY04_RS12235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY04_RS12240	COG0049	tRNA binding
HPY04_RS12255	COG2923	Belongs to the DsrF TusC family
HPY04_RS12260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY04_RS12265	COG2964	Protein conserved in bacteria
HPY04_RS12270	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY04_RS12280	COG2900	Belongs to the SlyX family
HPY04_RS12285	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY04_RS12290	COG0330	HflC and HflK could
HPY04_RS12295	COG0330	HflC and HflK could
HPY04_RS12300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY04_RS12305	COG1923	regulation of RNA biosynthetic process
HPY04_RS12310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY04_RS12315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY04_RS12325	COG0802	atpase or kinase
HPY04_RS12330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY04_RS12380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY04_RS12385	COG1162	GTPase activity
HPY04_RS12390	COG0688	phosphatidylethanolamine metabolic process
HPY04_RS12395	COG0471	metal ion transport
HPY04_RS12405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY04_RS12410	COG4942	peptidase
HPY04_RS12425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY04_RS12430	COG2816	NAD+ diphosphatase activity
HPY04_RS12435	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY04_RS12440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY04_RS12445	COG0085	RNA polymerase activity
HPY04_RS12450	COG0222	ribosome binding
HPY04_RS12455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY04_RS12465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY04_RS12470	COG0250	Participates in transcription elongation, termination and antitermination
HPY04_RS12475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY04_RS12480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY04_RS12505	COG1072	(Pantothenic acid kinase))
HPY04_RS12515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY04_RS12525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY04_RS12570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY04_RS12585	COG3118	belongs to the thioredoxin family
HPY04_RS12590	COG0513	Belongs to the DEAD box helicase family
HPY04_RS12600	COG2205	protein histidine kinase activity
HPY04_RS12600	COG0784	Response regulator, receiver
HPY04_RS12605	COG2814	Major facilitator Superfamily
HPY04_RS12620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY04_RS12625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY04_RS12630	COG0511	ligase activity, forming carbon-carbon bonds
HPY04_RS12635	COG0439	Biotin carboxylase
HPY04_RS12640	COG2264	protein methyltransferase activity
HPY04_RS12645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY04_RS12650	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY04_RS12655	COG1609	Transcriptional regulator
HPY04_RS12660	COG0129	dihydroxy-acid dehydratase activity
HPY04_RS12665	COG3265	gluconokinase activity
HPY04_RS12675	COG0800	Aldolase
HPY04_RS12695	COG0840	transmembrane signaling receptor activity
HPY04_RS12700	COG1982	Orn Lys Arg decarboxylase major
HPY04_RS12705	COG0531	amino acid
HPY04_RS12710	COG3710	Transcriptional regulator
HPY04_RS12715	COG0789	Transcriptional regulator
HPY04_RS12730	COG0151	Belongs to the GarS family
HPY04_RS12740	COG0776	regulation of translation
HPY04_RS12745	COG1253	flavin adenine dinucleotide binding
HPY04_RS12760	COG3068	Protein conserved in bacteria
HPY04_RS12770	COG1573	uracil-dna glycosylase
HPY04_RS12775	COG0668	transmembrane transport
HPY04_RS12790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY04_RS12800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPY04_RS12835	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY04_RS12850	COG1596	polysaccharide export
HPY04_RS12870	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY04_RS12880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY04_RS12915	COG0463	Glycosyl transferase, family 2
HPY04_RS12930	COG4106	trans-aconitate 2-methyltransferase activity
HPY04_RS12965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY04_RS12985	COG0859	PFAM glycosyl transferase family 9
HPY04_RS12995	COG1519	Transferase
HPY04_RS13000	COG0456	acetyltransferase
HPY04_RS13005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY04_RS13020	COG3642	lipopolysaccharide core region biosynthetic process
HPY04_RS13025	COG0859	PFAM glycosyl transferase family 9
HPY04_RS13030	COG0463	Glycosyl transferase, family 2
HPY04_RS13035	COG0859	PFAM glycosyl transferase family 9
HPY04_RS13040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY04_RS13045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY04_RS13055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY04_RS13060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY04_RS13065	COG2003	Belongs to the UPF0758 family
HPY04_RS13075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY04_RS13085	COG1309	transcriptional regulator
HPY04_RS13090	COG1560	Kdo2-lipid A biosynthetic process
HPY04_RS13095	COG1560	Kdo2-lipid A biosynthetic process
HPY04_RS13100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY04_RS13105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY04_RS13110	COG1561	YicC-like family, N-terminal region
HPY04_RS13125	COG0464	growth
HPY04_RS13130	COG1404	Belongs to the peptidase S8 family
HPY04_RS13255	COG2862	Uncharacterized protein family, UPF0114
HPY04_RS13260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_RS13260	COG1263	PTS System
HPY04_RS13265	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY04_RS13285	COG1120	ATPase activity
HPY04_RS13290	COG4774	siderophore transport
HPY04_RS13295	COG1132	(ABC) transporter
HPY04_RS13310	COG0514	ATP-dependent DNA helicase (RecQ)
HPY04_RS13315	COG2962	Rard protein
HPY04_RS13320	COG0405	Gamma-glutamyltransferase
HPY04_RS13330	COG1280	lysine exporter protein (LysE YggA)
HPY04_RS13340	COG0210	DNA helicase
HPY04_RS13350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY04_RS13355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY04_RS13365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_RS13375	COG0747	negative chemotaxis
HPY04_RS13425	COG1309	transcriptional regulator
HPY04_RS13430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY04_RS13435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY04_RS13440	COG2960	long-chain fatty acid transporting porin activity
HPY04_RS13445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY04_RS13450	COG0583	DNA-binding transcription factor activity
HPY04_RS13520	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY04_RS13525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY04_RS13530	COG1739	Uncharacterized protein family UPF0029
HPY04_RS13535	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY04_RS13535	COG1024	Enoyl-CoA hydratase
HPY04_RS13540	COG0183	Belongs to the thiolase family
HPY04_RS13545	COG0583	DNA-binding transcription factor activity
HPY04_RS13550	COG2814	Major facilitator Superfamily
HPY04_RS13560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY04_RS13565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY04_RS13570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY04_RS13575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY04_RS13580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY04_RS13585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY04_RS13595	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY04_RS13600	COG3312	ion transport
HPY04_RS13605	COG1475	DNA binding
HPY04_RS13610	COG1192	Involved in chromosome partitioning
HPY04_RS13615	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY04_RS13620	COG0445	tRNA wobble uridine modification
HPY04_RS13625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY04_RS13630	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY04_RS13635	COG0706	membrane insertase activity
HPY04_RS13645	COG0594	ribonuclease P activity
HPY04_RS13650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY04_RS13655	COG1126	abc transporter atp-binding protein
HPY04_RS13700	COG0217	transcriptional regulatory protein
HPY04_RS13705	COG2084	Dehydrogenase
HPY04_RS13720	COG2909	trisaccharide binding
HPY04_RS13725	COG0058	SHG alpha-glucan phosphorylase activity
HPY04_RS13730	COG1640	4-alpha-glucanotransferase
HPY04_RS13735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY04_RS13745	COG3501	Rhs element vgr protein
HPY04_RS13780	COG0471	metal ion transport
HPY04_RS13785	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY04_RS13825	COG0671	phosphoesterase, PA-phosphatase related
HPY04_RS13830	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY04_RS13840	COG1999	signal sequence binding
HPY04_RS13855	COG0786	glutamate:sodium symporter activity
HPY04_RS13875	COG3706	GGDEF domain
HPY04_RS13890	COG0813	purine-nucleoside phosphorylase activity
HPY04_RS13895	COG3272	Protein of unknown function (DUF1722)
HPY04_RS13905	COG0415	Belongs to the DNA photolyase family
HPY04_RS13910	COG1376	ErfK ybiS ycfS ynhG family protein
HPY04_RS13910	COG1388	LysM domain
HPY04_RS13920	COG0513	Belongs to the DEAD box helicase family
HPY04_RS13925	COG1770	oligopeptidase
HPY04_RS13955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY04_RS13960	COG0573	inorganic phosphate transmembrane transporter activity
HPY04_RS13965	COG0581	inorganic phosphate transmembrane transporter activity
HPY04_RS13970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY04_RS13990	COG0659	secondary active sulfate transmembrane transporter activity
HPY04_RS14000	COG0739	heme binding
HPY04_RS14005	COG5001	Diguanylate cyclase
HPY04_RS14005	COG3300	MHYT domain
HPY04_RS14010	COG0583	DNA-binding transcription factor activity
HPY04_RS14015	COG2814	Major facilitator Superfamily
HPY04_RS14035	COG1301	dicarboxylic acid transport
HPY04_RS14045	COG1342	Belongs to the UPF0251 family
HPY04_RS14075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY04_RS14080	COG0673	inositol 2-dehydrogenase activity
HPY04_RS14090	COG2200	EAL domain
HPY04_RS14090	COG2771	luxR family
HPY04_RS14095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY04_RS14105	COG0564	pseudouridine synthase activity
HPY04_RS14195	COG3501	Rhs element vgr protein
HPY04_RS14210	COG1869	D-ribose catabolic process
HPY04_RS14215	COG1129	ABC transporter
HPY04_RS14220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY04_RS14225	COG1879	ABC-type sugar transport system periplasmic component
HPY04_RS14230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_RS14235	COG1609	Transcriptional regulator
HPY04_RS14245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY04_RS14255	COG0584	glycerophosphoryl diester phosphodiesterase
HPY04_RS14260	COG2271	Major facilitator Superfamily
HPY04_RS14295	COG0579	oxidoreductase
HPY04_RS14305	COG0242	peptide deformylase activity
HPY04_RS14315	COG1320	monovalent cation:proton antiporter activity
HPY04_RS14320	COG2212	antiporter activity
HPY04_RS14340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY04_RS14340	COG2111	Na H antiporter
HPY04_RS14350	COG0589	response to stress
HPY04_RS14355	COG0814	amino acid
HPY04_RS14370	COG3530	Putative quorum-sensing-regulated virulence factor
HPY04_RS14380	COG5002	protein histidine kinase activity
HPY04_RS14380	COG5001	Diguanylate cyclase
HPY04_RS14385	COG1278	Cold shock
HPY04_RS14400	COG2304	oxidoreductase activity
HPY04_RS14420	COG0714	Associated with various cellular activities
HPY04_RS14425	COG0840	transmembrane signaling receptor activity
HPY04_RS14440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY04_RS14445	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY04_RS14455	COG3604	Transcriptional regulator
HPY04_RS14460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY04_RS14460	COG1017	nitric oxide dioxygenase activity
HPY04_RS14465	COG1278	Cold shock
HPY04_RS14470	COG3036	rescue of stalled ribosome
HPY04_RS14495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY04_RS14495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY04_RS14500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY04_RS14510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY04_RS14520	COG0516	GMP reductase activity
HPY04_RS14530	COG4974	Belongs to the 'phage' integrase family
HPY04_RS14535	COG0464	growth
HPY04_RS14610	COG4695	Portal protein
HPY04_RS14750	COG2205	protein histidine kinase activity
HPY04_RS14755	COG0745	RESPONSE REGULATOR receiver
HPY04_RS14765	COG0569	domain protein
HPY04_RS14795	COG0513	Belongs to the DEAD box helicase family
HPY04_RS14800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY04_RS14805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY04_RS14810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY04_RS14815	COG3437	response regulator, receiver
HPY04_RS14815	COG0784	Response regulator, receiver
HPY04_RS14820	COG4191	Histidine kinase
HPY04_RS14820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_RS14830	COG1757	Na H antiporter
HPY04_RS14835	COG2814	Major facilitator Superfamily
HPY04_RS14850	COG3240	lipase activity
HPY04_RS14860	COG0840	transmembrane signaling receptor activity
HPY04_RS14865	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY04_RS14870	COG5380	lipid catabolic process
HPY04_RS14895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_RS14900	COG4605	iron ion homeostasis
HPY04_RS14905	COG4604	ABC transporter, ATP-binding protein
HPY04_RS14910	COG2207	Transcriptional regulator
HPY04_RS14925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY04_RS14945	COG0745	RESPONSE REGULATOR receiver
HPY04_RS14955	COG3623	hexulose-6-phosphate isomerase
HPY04_RS14960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY04_RS14965	COG0561	phosphatase activity
HPY04_RS15015	COG0745	RESPONSE REGULATOR receiver
HPY04_RS15020	COG5002	protein histidine kinase activity
HPY04_RS15040	COG1686	Belongs to the peptidase S11 family
HPY04_RS15060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY04_RS15060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY04_RS15065	COG0509	glycine decarboxylation via glycine cleavage system
HPY04_RS15070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY04_RS15080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY04_RS15095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY04_RS15100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY04_RS15110	COG3040	lipid binding
HPY04_RS15145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_RS15155	COG1028	Short-chain dehydrogenase reductase Sdr
HPY04_RS15170	COG3040	lipid binding
HPY04_RS15210	COG0456	acetyltransferase
HPY04_RS15510	COG3041	Addiction module toxin RelE StbE family
HPY04_RS15570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_RS15625	COG3549	Plasmid maintenance system killer
HPY04_RS15630	COG3093	addiction module antidote protein HigA
HPY04_RS15710	COG0110	maltose O-acetyltransferase activity
HPY04_RS15760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_RS15820	COG1418	mRNA catabolic process
HPY04_RS15830	COG5642	Protein of unknown function (DUF2384)
HPY04_RS15840	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY04_RS15850	COG1328	CTP reductase activity
HPY04_RS15855	COG0602	queuosine metabolic process
HPY04_RS15865	COG0189	ligase activity
HPY04_RS15865	COG4067	protein conserved in archaea
HPY04_RS15870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY04_RS15870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY04_RS15870	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY04_RS15875	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY04_RS15880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_RS15880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_RS15885	COG1609	Transcriptional regulator
HPY04_RS15890	COG0420	3'-5' exonuclease activity
HPY04_RS15895	COG0419	ATPase involved in DNA repair
HPY04_RS15900	COG2205	protein histidine kinase activity
HPY04_RS15900	COG0784	Response regulator, receiver
HPY04_RS15905	COG0156	8-amino-7-oxononanoate synthase activity
HPY04_RS15915	COG0038	chloride channel
HPY04_RS15920	COG0523	cobalamin synthesis protein
HPY04_RS15930	COG3158	transport of potassium into the cell
HPY04_RS15935	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY04_RS15935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY04_RS15935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY04_RS15935	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY04_RS15940	COG2205	protein histidine kinase activity
HPY04_RS15945	COG0745	RESPONSE REGULATOR receiver
HPY04_RS15950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY04_RS15955	COG0586	Pfam SNARE associated Golgi protein
HPY04_RS15965	COG2200	EAL domain
HPY04_RS15975	COG3038	cytochrome b561
HPY04_RS15985	COG2116	formate transmembrane transporter activity
HPY04_RS15990	COG0583	DNA-binding transcription factor activity
HPY04_RS16000	COG3593	DNA synthesis involved in DNA repair
HPY04_RS16005	COG0737	Belongs to the 5'-nucleotidase family
HPY04_RS16020	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY04_RS16070	COG3706	GGDEF domain
HPY04_RS16085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY04_RS16090	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY04_RS16100	COG0745	RESPONSE REGULATOR receiver
HPY04_RS16115	COG3140	Belongs to the UPF0181 family
HPY04_RS16185	COG0023	Translation Initiation Factor
HPY04_RS16205	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY04_RS16205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_RS16205	COG1042	CoA-binding domain protein
HPY04_RS16210	COG0583	DNA-binding transcription factor activity
HPY04_RS16215	COG4771	TonB-dependent receptor
HPY04_RS16215	COG1629	transport
HPY04_RS16230	COG2050	protein possibly involved in aromatic compounds catabolism
HPY04_RS16250	COG0625	glutathione transferase activity
HPY04_RS16265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY04_RS16270	COG4172	Belongs to the ABC transporter superfamily
HPY04_RS16275	COG4239	(ABC) transporter, permease
HPY04_RS16285	COG4166	transmembrane transport
HPY04_RS16325	COG3842	ATPase activity
HPY04_RS16330	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY04_RS16335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY04_RS16345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY04_RS16350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY04_RS16360	COG3842	ATPase activity
HPY04_RS16370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY04_RS16385	COG1175	transmembrane transport
HPY04_RS16390	COG3833	ABC-type maltose transport systems, permease component
HPY04_RS16410	COG1011	Hydrolase
HPY04_RS16425	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY04_RS16430	COG1970	mechanosensitive ion channel activity
HPY04_RS16435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY04_RS16440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_RS16440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY04_RS16445	COG0302	gtp cyclohydrolase
HPY04_RS16455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY04_RS16465	COG2897	thiosulfate sulfurtransferase activity
HPY04_RS16470	COG2390	Transcriptional regulator
HPY04_RS16480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY04_RS16510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY04_RS16520	COG0494	nUDIX hydrolase
HPY04_RS16535	COG0583	DNA-binding transcription factor activity
HPY04_RS16540	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY04_RS16580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY04_RS16630	COG0745	RESPONSE REGULATOR receiver
HPY04_RS16640	COG1263	PTS System
HPY04_RS16640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY04_RS16650	COG1621	beta-fructofuranosidase activity
HPY04_RS16655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_RS16660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY04_RS16670	COG2885	chlorophyll binding
HPY04_RS16675	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY04_RS16680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY04_RS16685	COG0840	transmembrane signaling receptor activity
HPY04_RS16690	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY04_RS16695	COG1760	l-serine dehydratase
HPY04_RS16700	COG2197	response regulator
HPY04_RS16705	COG3850	Histidine kinase
HPY04_RS16710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY04_RS16720	COG0243	molybdopterin cofactor binding
HPY04_RS16740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY04_RS16745	COG2197	response regulator
HPY04_RS16750	COG3851	Histidine kinase
HPY04_RS16755	COG2271	Major facilitator Superfamily
HPY04_RS16760	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY04_RS16770	COG3842	ATPase activity
HPY04_RS16775	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY04_RS16785	COG0183	Belongs to the thiolase family
HPY04_RS16795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_RS16800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY04_RS16815	COG3706	GGDEF domain
HPY04_RS16820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY04_RS16830	COG1979	alcohol dehydrogenase
HPY04_RS16845	COG4191	Histidine kinase
HPY04_RS16855	COG2271	Major facilitator Superfamily
HPY04_RS16860	COG0469	pyruvate kinase activity
HPY04_RS16870	COG1879	ABC-type sugar transport system periplasmic component
HPY04_RS16875	COG1803	Methylglyoxal synthase
HPY04_RS16880	COG1335	isochorismatase
HPY04_RS16885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY04_RS16890	COG0210	DNA helicase
HPY04_RS16895	COG1289	transmembrane transporter activity
HPY04_RS16925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY04_RS16930	COG4149	molybdate abc transporter
HPY04_RS16935	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY04_RS16940	COG1492	cobalamin metabolic process
HPY04_RS16975	COG5002	protein histidine kinase activity
HPY04_RS16975	COG0784	Response regulator, receiver
HPY04_RS16980	COG1879	ABC-type sugar transport system periplasmic component
HPY04_RS16990	COG2827	Endonuclease containing a URI domain
HPY04_RS16995	COG3132	Protein of unknown function, DUF480
HPY04_RS17005	COG2926	Belongs to the UPF0265 family
HPY04_RS17020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY04_RS17025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY04_RS17035	COG0247	lactate metabolic process
HPY04_RS17040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY04_RS17045	COG3118	belongs to the thioredoxin family
HPY04_RS17075	COG0583	DNA-binding transcription factor activity
HPY04_RS17080	COG4160	amino acid transport
HPY04_RS17085	COG4215	(ABC) transporter
HPY04_RS17090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_RS17095	COG1126	abc transporter atp-binding protein
HPY04_RS17105	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY04_RS17115	COG0494	nUDIX hydrolase
HPY04_RS17120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY04_RS17130	COG1309	transcriptional regulator
HPY04_RS17135	COG0513	Belongs to the DEAD box helicase family
HPY04_RS17140	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY04_RS17145	COG0814	amino acid
HPY04_RS17150	COG0840	transmembrane signaling receptor activity
HPY04_RS17155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY04_RS17160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY04_RS17165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPY04_RS17170	COG1984	allophanate hydrolase subunit 2
HPY04_RS17185	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY04_RS17190	COG4181	ATPase activity
HPY04_RS17200	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY04_RS17205	COG1716	ATPase activity
HPY04_RS17205	COG5001	Diguanylate cyclase
HPY04_RS17215	COG0484	heat shock protein binding
HPY04_RS17230	COG0546	phosphoglycolate phosphatase activity
HPY04_RS17245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY04_RS17250	COG1368	sulfuric ester hydrolase activity
HPY04_RS17260	COG0513	Belongs to the DEAD box helicase family
HPY04_RS17275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY04_RS17285	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY04_RS17290	COG3397	chitin binding
HPY04_RS17295	COG3227	Zinc metalloprotease (Elastase)
HPY04_RS17310	COG1166	arginine decarboxylase activity
HPY04_RS17320	COG2239	Acts as a magnesium transporter
HPY04_RS17325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY04_RS17330	COG0459	protein refolding
HPY04_RS17340	COG0527	aspartate kinase activity
HPY04_RS17345	COG0662	Cupin 2, conserved barrel domain protein
HPY04_RS17350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY04_RS17355	COG0456	acetyltransferase
HPY04_RS17360	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY04_RS17365	COG3186	Phenylalanine-4-hydroxylase
HPY04_RS17370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY04_RS17385	COG2264	protein methyltransferase activity
HPY04_RS17410	COG1253	flavin adenine dinucleotide binding
HPY04_RS17415	COG1765	OsmC-like protein
HPY04_RS17450	COG1252	NADH dehydrogenase
HPY04_RS17455	COG0531	amino acid
HPY04_RS17460	COG3706	GGDEF domain
HPY04_RS17470	COG3279	Response regulator of the LytR AlgR family
HPY04_RS17475	COG3275	phosphorelay sensor kinase activity
HPY04_RS17495	COG1136	(ABC) transporter
HPY04_RS17505	COG4989	oxidoreductase activity
HPY04_RS17510	COG0366	Alpha amylase catalytic
HPY04_RS17520	COG2067	long-chain fatty acid transport protein
HPY04_RS17525	COG2267	carboxylic ester hydrolase activity
HPY04_RS17535	COG3227	Zinc metalloprotease (Elastase)
HPY04_RS17545	COG3047	cAMP biosynthetic process
HPY04_RS17555	COG1686	Belongs to the peptidase S11 family
HPY04_RS17560	COG0557	exoribonuclease II activity
HPY04_RS17565	COG1278	Cold shock
HPY04_RS17575	COG3048	D-serine ammonia-lyase activity
HPY04_RS17580	COG0583	DNA-binding transcription factor activity
HPY04_RS17595	COG1162	GTPase activity
HPY04_RS17605	COG2264	protein methyltransferase activity
HPY04_RS17610	COG1063	alcohol dehydrogenase
HPY04_RS17635	COG1278	Cold shock
HPY04_RS17640	COG0557	exoribonuclease II activity
HPY04_RS17755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY04_RS17760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY04_RS17765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY04_RS17785	COG1278	Cold shock
HPY04_RS17810	COG4626	Terminase
HPY04_RS17810	COG1802	Transcriptional regulator
HPY04_RS17835	COG0582	viral genome integration into host DNA
HPY04_RS17860	COG1063	alcohol dehydrogenase
HPY04_RS17870	COG2873	o-acetylhomoserine
HPY04_RS17880	COG0346	lactoylglutathione lyase activity
HPY04_RS17905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY04_RS17910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY04_RS17915	COG0363	glucosamine-6-phosphate deaminase activity
HPY04_RS17920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY04_RS17945	COG1929	Belongs to the glycerate kinase type-1 family
HPY04_RS17950	COG2610	gluconate transmembrane transporter activity
HPY04_RS17955	COG3835	regulator
HPY04_RS17965	COG0748	coenzyme F420 binding
HPY04_RS17970	COG3721	Heme iron utilization protein
HPY04_RS17980	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY04_RS17985	COG0811	peptide transport
HPY04_RS17990	COG0848	biopolymer transport protein
HPY04_RS17995	COG4558	Periplasmic binding protein
HPY04_RS18000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY04_RS18005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY04_RS18040	COG0633	Ferredoxin
HPY04_RS18040	COG3217	Mosc domain protein beta barrel domain protein
HPY04_RS18040	COG3217	Mosc domain protein beta barrel domain protein
HPY04_RS18040	COG0633	Ferredoxin
HPY04_RS18045	COG0418	dihydroorotase activity
HPY04_RS18050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY04_RS18055	COG2354	Protein conserved in bacteria
HPY04_RS18060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY04_RS18065	COG1278	Cold shock
HPY04_RS18090	COG3706	GGDEF domain
HPY04_RS18095	COG1349	DNA-binding transcription factor activity
HPY04_RS18110	COG3833	ABC-type maltose transport systems, permease component
HPY04_RS18115	COG1175	transmembrane transport
HPY04_RS18125	COG3842	ATPase activity
HPY04_RS18130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY04_RS18145	COG0393	Putative heavy-metal-binding
HPY04_RS18155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY04_RS18160	COG0784	Response regulator, receiver
HPY04_RS18160	COG0835	chemotaxis
HPY04_RS18165	COG1846	Transcriptional regulator
HPY04_RS18170	COG3706	GGDEF domain
HPY04_RS18205	COG0583	DNA-binding transcription factor activity
HPY04_RS18210	COG5001	Diguanylate cyclase
HPY04_RS18220	COG1741	Belongs to the pirin family
HPY04_RS18225	COG3123	guanosine phosphorylase activity
HPY04_RS18235	COG2211	Major facilitator Superfamily
HPY04_RS18240	COG1067	ATP-dependent peptidase activity
HPY04_RS18250	COG4172	Belongs to the ABC transporter superfamily
HPY04_RS18270	COG0583	DNA-binding transcription factor activity
HPY04_RS18280	COG1620	l-lactate permease
HPY04_RS18295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY04_RS18305	COG0840	transmembrane signaling receptor activity
HPY04_RS18315	COG1472	Belongs to the glycosyl hydrolase 3 family
HPY04_RS18325	COG4580	involved in the transport of maltose and maltodextrins
HPY04_RS18340	COG1609	Transcriptional regulator
HPY04_RS18350	COG4608	Belongs to the ABC transporter superfamily
HPY04_RS18355	COG0444	Belongs to the ABC transporter superfamily
HPY04_RS18360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_RS18370	COG0747	negative chemotaxis
HPY04_RS18380	COG0513	Belongs to the DEAD box helicase family
HPY04_RS18385	COG0583	DNA-binding transcription factor activity
HPY04_RS18395	COG1902	pentaerythritol trinitrate reductase activity
HPY04_RS18405	COG1132	(ABC) transporter
HPY04_RS18415	COG1902	pentaerythritol trinitrate reductase activity
HPY04_RS18425	COG1280	lysine exporter protein (LysE YggA)
HPY04_RS18430	COG2207	Transcriptional regulator
HPY04_RS18445	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPY04_RS18450	COG1846	Transcriptional regulator
HPY04_RS18455	COG1764	response to oxidative stress
HPY04_RS18460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY04_RS18465	COG0697	spore germination
HPY04_RS18475	COG0700	Nucleoside recognition
HPY04_RS18480	COG3366	ferrous iron transmembrane transporter activity
HPY04_RS18485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY04_RS18495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY04_RS18500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY04_RS18505	COG2259	Doxx family
HPY04_RS18530	COG0363	glucosamine-6-phosphate deaminase activity
HPY04_RS18540	COG0583	DNA-binding transcription factor activity
HPY04_RS18545	COG0366	Alpha amylase catalytic
HPY04_RS18565	COG4580	involved in the transport of maltose and maltodextrins
HPY04_RS18580	COG0840	transmembrane signaling receptor activity
HPY04_RS18590	COG0840	transmembrane signaling receptor activity
HPY04_RS18600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY04_RS18605	COG1126	abc transporter atp-binding protein
HPY04_RS18615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY04_RS18620	COG4597	amino acid ABC transporter
HPY04_RS18625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY04_RS18630	COG2213	PTS system mannitol-specific
HPY04_RS18630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY04_RS18635	COG0246	Mannitol dehydrogenase
HPY04_RS18640	COG3722	fumarate hydratase activity
HPY04_RS18645	COG0673	inositol 2-dehydrogenase activity
HPY04_RS18665	COG0697	spore germination
HPY04_RS18680	COG1335	isochorismatase
HPY04_RS18690	COG2910	NAD(P)H-binding
HPY04_RS18700	COG0840	transmembrane signaling receptor activity
HPY04_RS18705	COG4221	oxidoreductase activity
HPY04_RS18710	COG0583	DNA-binding transcription factor activity
HPY04_RS18715	COG1901	pseudouridine methyltransferase
HPY04_RS18730	COG0531	amino acid
HPY04_RS18735	COG1982	Orn Lys Arg decarboxylase major
HPY04_RS18765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY04_RS18790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY04_RS18830	COG0745	RESPONSE REGULATOR receiver
HPY04_RS18855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY04_RS18860	COG0840	transmembrane signaling receptor activity
HPY04_RS18865	COG0835	chemotaxis
HPY04_RS18870	COG0835	chemotaxis
HPY04_RS18875	COG0643	Histidine kinase
HPY04_RS18875	COG2198	Histidine kinase
HPY04_RS18895	COG0601	transmembrane transport
HPY04_RS18900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY04_RS18910	COG2194	sulfuric ester hydrolase activity
HPY04_RS18915	COG0642	Histidine kinase
HPY04_RS18920	COG0745	RESPONSE REGULATOR receiver
HPY04_RS18950	COG1444	tRNA N-acetyltransferase activity
HPY04_RS18955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine