locus-tag	class	description
HPY14_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY14_RS00010	COG0592	DNA-directed DNA polymerase activity
HPY14_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY14_RS00020	COG0187	DNA topoisomerase II activity
HPY14_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY14_RS00035	COG3977	Valine--pyruvate aminotransferase
HPY14_RS00040	COG0751	glycine-tRNA ligase activity
HPY14_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY14_RS00050	COG2119	membrane
HPY14_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY14_RS00070	COG0604	alcohol dehydrogenase
HPY14_RS00080	COG0129	dihydroxy-acid dehydratase activity
HPY14_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY14_RS00100	COG0606	chelatase, subunit chli
HPY14_RS00105	COG0204	Acyl-transferase
HPY14_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY14_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY14_RS00125	COG3084	Protein conserved in bacteria
HPY14_RS00130	COG4326	sporulation control protein
HPY14_RS00135	COG1272	protein, Hemolysin III
HPY14_RS00145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY14_RS00150	COG0569	domain protein
HPY14_RS00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY14_RS00155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY14_RS00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY14_RS00165	COG0242	peptide deformylase activity
HPY14_RS00170	COG1652	LysM domain
HPY14_RS00175	COG0758	DNA mediated transformation
HPY14_RS00180	COG2922	Belongs to the Smg family
HPY14_RS00185	COG0551	DNA topoisomerase type I activity
HPY14_RS00190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY14_RS00195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY14_RS00200	COG0009	L-threonylcarbamoyladenylate synthase
HPY14_RS00205	COG0408	coproporphyrinogen oxidase activity
HPY14_RS00210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY14_RS00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY14_RS00255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY14_RS00260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY14_RS00270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY14_RS00275	COG2104	thiamine diphosphate biosynthetic process
HPY14_RS00280	COG2022	thiamine diphosphate biosynthetic process
HPY14_RS00285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY14_RS00290	COG0006	proline dipeptidase activity
HPY14_RS00290	COG0006	proline dipeptidase activity
HPY14_RS00310	COG1522	sequence-specific DNA binding
HPY14_RS00315	COG5001	Diguanylate cyclase
HPY14_RS00315	COG5002	protein histidine kinase activity
HPY14_RS00335	COG0589	response to stress
HPY14_RS00340	COG1528	Iron-storage protein
HPY14_RS00350	COG2081	HI0933 family
HPY14_RS00360	COG1322	Protein conserved in bacteria
HPY14_RS00365	COG2226	methyltransferase
HPY14_RS00380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY14_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY14_RS00390	COG0805	protein transport
HPY14_RS00395	COG1858	cytochrome C peroxidase
HPY14_RS00400	COG0534	Mate efflux family protein
HPY14_RS00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY14_RS00415	COG2937	Belongs to the GPAT DAPAT family
HPY14_RS00420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY14_RS00425	COG3161	chorismate lyase activity
HPY14_RS00430	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY14_RS00435	COG0840	transmembrane signaling receptor activity
HPY14_RS00445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY14_RS00450	COG0084	hydrolase, TatD family'
HPY14_RS00465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY14_RS00465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY14_RS00485	COG3078	GTPase activator activity
HPY14_RS00500	COG3071	HemY protein
HPY14_RS00505	COG2959	enzyme of heme biosynthesis
HPY14_RS00510	COG1587	Uroporphyrinogen-III synthase
HPY14_RS00515	COG0181	hydroxymethylbilane synthase activity
HPY14_RS00525	COG1965	Belongs to the frataxin family
HPY14_RS00535	COG0019	diaminopimelate decarboxylase activity
HPY14_RS00540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY14_RS00550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY14_RS00555	COG1011	Hydrolase
HPY14_RS00560	COG2199	diguanylate cyclase activity
HPY14_RS00560	COG2200	EAL domain
HPY14_RS00560	COG3287	FIST C domain
HPY14_RS00575	COG0561	phosphatase activity
HPY14_RS00580	COG2267	carboxylic ester hydrolase activity
HPY14_RS00585	COG1280	lysine exporter protein (LysE YggA)
HPY14_RS00590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY14_RS00595	COG0783	Belongs to the Dps family
HPY14_RS00625	COG0742	ribosomal rna small subunit methyltransferase
HPY14_RS00630	COG0552	protein localization to endoplasmic reticulum
HPY14_RS00635	COG2884	Cell division ATP-binding protein ftsE
HPY14_RS00640	COG2177	Part of the ABC transporter FtsEX involved in
HPY14_RS00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY14_RS00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY14_RS00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY14_RS00670	COG4206	TonB-dependent receptor
HPY14_RS00675	COG1404	Belongs to the peptidase S8 family
HPY14_RS00680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY14_RS00745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY14_RS00750	COG5001	Diguanylate cyclase
HPY14_RS00750	COG3300	MHYT domain
HPY14_RS00760	COG3852	Histidine kinase
HPY14_RS00770	COG0174	glutamine synthetase
HPY14_RS00790	COG1295	ribonuclease BN
HPY14_RS00795	COG1490	D-aminoacyl-tRNA deacylase activity
HPY14_RS00800	COG0456	acetyltransferase
HPY14_RS00810	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY14_RS00815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY14_RS00820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY14_RS00825	COG3031	protein transport across the cell outer membrane
HPY14_RS00835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY14_RS00840	COG1459	type II secretion system
HPY14_RS00845	COG2165	general secretion pathway protein
HPY14_RS00850	COG2165	general secretion pathway protein
HPY14_RS00855	COG2165	general secretion pathway protein
HPY14_RS00860	COG4795	General secretion pathway protein
HPY14_RS00865	COG3156	type II secretion system protein K
HPY14_RS00870	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY14_RS00875	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY14_RS00885	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY14_RS00890	COG0494	nUDIX hydrolase
HPY14_RS00900	COG1040	competence protein
HPY14_RS00910	COG0596	Alpha beta hydrolase
HPY14_RS00920	COG2183	response to ionizing radiation
HPY14_RS00925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY14_RS00930	COG0745	RESPONSE REGULATOR receiver
HPY14_RS00940	COG2233	PERMEase
HPY14_RS00945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY14_RS00950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY14_RS00955	COG1758	RNA polymerase activity
HPY14_RS00960	COG0194	GDP metabolic process
HPY14_RS00965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY14_RS00970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY14_RS00990	COG4232	protein-disulfide reductase activity
HPY14_RS01000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY14_RS01005	COG1027	Aspartate ammonia-lyase
HPY14_RS01010	COG3706	GGDEF domain
HPY14_RS01015	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY14_RS01020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY14_RS01030	COG2205	protein histidine kinase activity
HPY14_RS01035	COG0745	RESPONSE REGULATOR receiver
HPY14_RS01045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY14_RS01050	COG0205	6-phosphofructokinase activity
HPY14_RS01055	COG1494	fructose-1,6-bisphosphatase
HPY14_RS01060	COG3074	FtsZ-dependent cytokinesis
HPY14_RS01065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY14_RS01070	COG0460	homoserine dehydrogenase
HPY14_RS01070	COG0527	aspartate kinase activity
HPY14_RS01075	COG0626	cystathionine gamma-synthase activity
HPY14_RS01080	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY14_RS01085	COG0281	malic enzyme
HPY14_RS01090	COG0254	rRNA binding
HPY14_RS01095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY14_RS01100	COG1609	Transcriptional regulator
HPY14_RS01105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY14_RS01110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY14_RS01115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY14_RS01120	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY14_RS01125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY14_RS01130	COG0534	Mate efflux family protein
HPY14_RS01135	COG0149	triose-phosphate isomerase activity
HPY14_RS01160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY14_RS01165	COG0459	protein refolding
HPY14_RS01175	COG1509	lysine 2,3-aminomutase activity
HPY14_RS01180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY14_RS01190	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY14_RS01195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY14_RS01200	COG1053	succinate dehydrogenase
HPY14_RS01205	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY14_RS01210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY14_RS01215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY14_RS01220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY14_RS01225	COG1045	serine acetyltransferase
HPY14_RS01235	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY14_RS01240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY14_RS01245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY14_RS01250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY14_RS01255	COG0137	argininosuccinate synthase activity
HPY14_RS01260	COG0165	Argininosuccinate lyase
HPY14_RS01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY14_RS01275	COG0678	peroxiredoxin activity
HPY14_RS01275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY14_RS01285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY14_RS01315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY14_RS01320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY14_RS01330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY14_RS01335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY14_RS01340	COG0546	phosphoglycolate phosphatase activity
HPY14_RS01345	COG0180	Tryptophanyl-tRNA synthetase
HPY14_RS01360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY14_RS01370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY14_RS01380	COG1012	belongs to the aldehyde dehydrogenase family
HPY14_RS01395	COG3954	Phosphoribulokinase
HPY14_RS01405	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY14_RS01415	COG0488	(ABC) transporter
HPY14_RS01420	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY14_RS01435	COG1047	Peptidyl-prolyl cis-trans
HPY14_RS01445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY14_RS01450	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY14_RS01455	COG3083	sulfuric ester hydrolase activity
HPY14_RS01460	COG0557	exoribonuclease II activity
HPY14_RS01465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY14_RS01470	COG0051	transcription antitermination factor activity, RNA binding
HPY14_RS01475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY14_RS01480	COG0088	Forms part of the polypeptide exit tunnel
HPY14_RS01485	COG0089	rRNA binding
HPY14_RS01490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY14_RS01495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY14_RS01500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY14_RS01505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY14_RS01510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY14_RS01515	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY14_RS01520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY14_RS01525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY14_RS01530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY14_RS01535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY14_RS01540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY14_RS01545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY14_RS01550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY14_RS01555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY14_RS01560	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY14_RS01565	COG1841	ribosomal large subunit assembly
HPY14_RS01575	COG0201	protein transport
HPY14_RS01580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY14_RS01585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY14_RS01590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY14_RS01595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY14_RS01600	COG0202	RNA polymerase activity
HPY14_RS01605	COG0203	ribosomal protein L17
HPY14_RS01615	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY14_RS01620	COG3061	Opacity-associated protein A
HPY14_RS01620	COG3266	domain, Protein
HPY14_RS01625	COG0697	spore germination
HPY14_RS01630	COG2153	protein acetylation
HPY14_RS01635	COG0513	Belongs to the DEAD box helicase family
HPY14_RS01645	COG0737	Belongs to the 5'-nucleotidase family
HPY14_RS01650	COG1648	precorrin-2 dehydrogenase activity
HPY14_RS01650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY14_RS01655	COG0175	sulfate reduction
HPY14_RS01660	COG2895	sulfate adenylyltransferase (ATP) activity
HPY14_RS01665	COG0529	Catalyzes the synthesis of activated sulfate
HPY14_RS01685	COG1136	(ABC) transporter
HPY14_RS01700	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY14_RS01705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY14_RS01710	COG0729	surface antigen
HPY14_RS01720	COG2105	PFAM AIG2 family protein
HPY14_RS01725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY14_RS01735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY14_RS01740	COG0163	prenyltransferase activity
HPY14_RS01750	COG1178	ABC-type Fe3 transport system permease component
HPY14_RS01755	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY14_RS01760	COG3028	Belongs to the UPF0307 family
HPY14_RS01765	COG0312	modulator of DNA gyrase
HPY14_RS01770	COG2239	Acts as a magnesium transporter
HPY14_RS01775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS01780	COG1660	Displays ATPase and GTPase activities
HPY14_RS01785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS01790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY14_RS01800	COG1137	ATPase activity
HPY14_RS01805	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY14_RS01820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY14_RS01820	COG0517	IMP dehydrogenase activity
HPY14_RS01830	COG1127	ABC transporter
HPY14_RS01835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY14_RS01840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY14_RS01845	COG2854	intermembrane phospholipid transfer
HPY14_RS01855	COG5007	Belongs to the BolA IbaG family
HPY14_RS01860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY14_RS01870	COG0251	oxidation-reduction process
HPY14_RS01880	COG0540	Belongs to the ATCase OTCase family
HPY14_RS01890	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY14_RS01900	COG0564	pseudouridine synthase activity
HPY14_RS01905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY14_RS01910	COG0525	valine-tRNA ligase activity
HPY14_RS01915	COG2927	DNA polymerase III (CHI subunit)
HPY14_RS01920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY14_RS01925	COG0795	lipopolysaccharide-transporting ATPase activity
HPY14_RS01930	COG0795	lipopolysaccharide-transporting ATPase activity
HPY14_RS01945	COG3437	response regulator, receiver
HPY14_RS01990	COG0066	3-isopropylmalate dehydratase activity
HPY14_RS01995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY14_RS02000	COG0473	3-isopropylmalate dehydrogenase activity
HPY14_RS02025	COG0583	DNA-binding transcription factor activity
HPY14_RS02030	COG1022	Amp-dependent synthetase and ligase
HPY14_RS02035	COG0028	Belongs to the TPP enzyme family
HPY14_RS02040	COG0440	acetolactate synthase activity
HPY14_RS02050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY14_RS02055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY14_RS02060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY14_RS02070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY14_RS02075	COG3079	Belongs to the UPF0149 family
HPY14_RS02080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY14_RS02085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY14_RS02100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY14_RS02110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY14_RS02115	COG1595	DNA-templated transcription, initiation
HPY14_RS02130	COG3086	response to oxidative stress
HPY14_RS02135	COG0481	GTPase activity
HPY14_RS02145	COG0571	ribonuclease III activity
HPY14_RS02150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY14_RS02155	COG1381	Involved in DNA repair and RecF pathway recombination
HPY14_RS02160	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY14_RS02165	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY14_RS02195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY14_RS02200	COG3956	TIGRFAM MazG family protein
HPY14_RS02205	COG0504	CTP synthase activity
HPY14_RS02210	COG0148	phosphopyruvate hydratase activity
HPY14_RS02215	COG0617	tRNA 3'-terminal CCA addition
HPY14_RS02220	COG3267	Type II secretory pathway component ExeA
HPY14_RS02220	COG3409	Peptidoglycan-binding domain 1 protein
HPY14_RS02230	COG4991	sh3 domain protein
HPY14_RS02235	COG0306	phosphate transporter
HPY14_RS02240	COG1392	Phosphate transport regulator
HPY14_RS02245	COG3025	triphosphatase activity
HPY14_RS02255	COG0840	transmembrane signaling receptor activity
HPY14_RS02260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY14_RS02270	COG1538	Outer membrane efflux protein
HPY14_RS02275	COG0494	nUDIX hydrolase
HPY14_RS02280	COG3151	Protein conserved in bacteria
HPY14_RS02290	COG3150	esterase
HPY14_RS02295	COG0187	DNA topoisomerase II activity
HPY14_RS02300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY14_RS02310	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY14_RS02315	COG0237	dephospho-CoA kinase activity
HPY14_RS02325	COG1459	type II secretion system
HPY14_RS02330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY14_RS02350	COG0716	FMN binding
HPY14_RS02355	COG4974	Belongs to the 'phage' integrase family
HPY14_RS02360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY14_RS02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY14_RS02370	COG2186	Transcriptional regulator
HPY14_RS02375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY14_RS02380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY14_RS02385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY14_RS02400	COG3116	cell division
HPY14_RS02405	COG0768	penicillin binding
HPY14_RS02410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY14_RS02415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY14_RS02425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY14_RS02430	COG0772	Belongs to the SEDS family
HPY14_RS02440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY14_RS02445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY14_RS02450	COG0849	cell division
HPY14_RS02455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY14_RS02460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY14_RS02470	COG0653	protein targeting
HPY14_RS02475	COG0494	nUDIX hydrolase
HPY14_RS02480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY14_RS02490	COG0505	Belongs to the CarA family
HPY14_RS02495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY14_RS02515	COG0730	response to heat
HPY14_RS02520	COG0583	DNA-binding transcription factor activity
HPY14_RS02525	COG2860	membrane
HPY14_RS02530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY14_RS02540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY14_RS02550	COG0493	'glutamate synthase
HPY14_RS02555	COG0070	glutamate synthase
HPY14_RS02555	COG0069	glutamate synthase activity
HPY14_RS02555	COG0067	glutamate synthase
HPY14_RS02565	COG0070	glutamate synthase
HPY14_RS02565	COG0069	glutamate synthase activity
HPY14_RS02565	COG0067	glutamate synthase
HPY14_RS02570	COG1242	4 iron, 4 sulfur cluster binding
HPY14_RS02575	COG3706	GGDEF domain
HPY14_RS02575	COG5001	Diguanylate cyclase
HPY14_RS02575	COG4251	negative regulation of phosphorylation
HPY14_RS02575	COG2203	Gaf domain
HPY14_RS02580	COG2198	Histidine kinase
HPY14_RS02580	COG0784	Response regulator, receiver
HPY14_RS02580	COG5002	protein histidine kinase activity
HPY14_RS02585	COG0745	RESPONSE REGULATOR receiver
HPY14_RS02595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY14_RS02615	COG0083	homoserine kinase activity
HPY14_RS02620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY14_RS02625	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY14_RS02630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY14_RS02635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY14_RS02650	COG1115	amino acid carrier protein
HPY14_RS02655	COG3022	response to hydroperoxide
HPY14_RS02665	COG0084	hydrolase, TatD family'
HPY14_RS02670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY14_RS02680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY14_RS02685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY14_RS02690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY14_RS02695	COG0813	purine-nucleoside phosphorylase activity
HPY14_RS02705	COG0560	Phosphoserine phosphatase
HPY14_RS02715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY14_RS02720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY14_RS02725	COG1022	Amp-dependent synthetase and ligase
HPY14_RS02740	COG3250	beta-galactosidase activity
HPY14_RS02745	COG1609	Transcriptional regulator
HPY14_RS02750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY14_RS02765	COG0189	ligase activity
HPY14_RS02765	COG0569	domain protein
HPY14_RS02770	COG0456	acetyltransferase
HPY14_RS02780	COG2171	N-acyltransferase activity
HPY14_RS02785	COG3141	response to X-ray
HPY14_RS02800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY14_RS02805	COG1074	ATP-dependent DNA helicase activity
HPY14_RS02810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY14_RS02820	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY14_RS02820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY14_RS02830	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY14_RS02835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY14_RS02840	COG2166	iron-sulfur cluster assembly
HPY14_RS02845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY14_RS02850	COG0693	protein deglycase activity
HPY14_RS02855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY14_RS02870	COG1595	DNA-templated transcription, initiation
HPY14_RS02880	COG2211	Major facilitator Superfamily
HPY14_RS02885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY14_RS02895	COG2813	Specifically methylates the guanine in position
HPY14_RS02900	COG0271	Belongs to the BolA IbaG family
HPY14_RS02905	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY14_RS02910	COG1805	sodium ion transport
HPY14_RS02915	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY14_RS02920	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY14_RS02925	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY14_RS02930	COG2871	sodium ion transport
HPY14_RS02935	COG1477	protein flavinylation
HPY14_RS02955	COG3706	GGDEF domain
HPY14_RS02960	COG0733	neurotransmitter:sodium symporter activity
HPY14_RS02970	COG0189	ligase activity
HPY14_RS02975	COG0189	ligase activity
HPY14_RS02975	COG4067	protein conserved in archaea
HPY14_RS02980	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY14_RS02985	COG2252	PERMEase
HPY14_RS02990	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY14_RS03005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY14_RS03010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY14_RS03015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY14_RS03020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY14_RS03020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY14_RS03035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY14_RS03040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY14_RS03045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY14_RS03050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY14_RS03060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY14_RS03065	COG0024	Methionine aminopeptidase
HPY14_RS03070	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY14_RS03075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY14_RS03080	COG0528	UMP kinase activity
HPY14_RS03085	COG0233	cytoplasmic translational termination
HPY14_RS03090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY14_RS03095	COG0575	Belongs to the CDS family
HPY14_RS03100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY14_RS03105	COG0750	zinc metalloprotease
HPY14_RS03115	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY14_RS03120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY14_RS03125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY14_RS03130	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY14_RS03135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY14_RS03140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY14_RS03145	COG0587	DNA-directed DNA polymerase activity
HPY14_RS03150	COG0825	malonyl-CoA metabolic process
HPY14_RS03155	COG0037	tRNA processing
HPY14_RS03165	COG3479	Phenolic acid decarboxylase
HPY14_RS03170	COG0347	Belongs to the P(II) protein family
HPY14_RS03175	COG3021	interspecies interaction between organisms
HPY14_RS03180	COG1388	LysM domain
HPY14_RS03180	COG0741	lytic transglycosylase activity
HPY14_RS03185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY14_RS03190	COG2226	methyltransferase
HPY14_RS03195	COG0328	RNA-DNA hybrid ribonuclease activity
HPY14_RS03210	COG1960	acyl-CoA dehydrogenase activity
HPY14_RS03215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY14_RS03220	COG0121	glutamine amidotransferase
HPY14_RS03225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY14_RS03230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY14_RS03235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY14_RS03240	COG3706	GGDEF domain
HPY14_RS03245	COG1187	pseudouridine synthase activity
HPY14_RS03250	COG2840	Smr protein MutS2
HPY14_RS03265	COG3735	TraB family
HPY14_RS03280	COG2608	mercury ion transmembrane transporter activity
HPY14_RS03280	COG2217	Heavy metal translocating P-type atpase
HPY14_RS03285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY14_RS03300	COG4774	siderophore transport
HPY14_RS03300	COG1629	transport
HPY14_RS03305	COG2375	cellular response to nickel ion
HPY14_RS03310	COG2226	methyltransferase
HPY14_RS03310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY14_RS03310	COG3433	isochorismatase activity
HPY14_RS03345	COG0835	chemotaxis
HPY14_RS03345	COG0784	Response regulator, receiver
HPY14_RS03350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY14_RS03355	COG1815	bacterial-type flagellum-dependent cell motility
HPY14_RS03370	COG1749	Flagellar hook protein flgE
HPY14_RS03375	COG4787	bacterial-type flagellum-dependent cell motility
HPY14_RS03385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY14_RS03390	COG1706	bacterial-type flagellum-dependent cell motility
HPY14_RS03395	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY14_RS03395	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY14_RS03410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY14_RS03415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY14_RS03500	COG0012	GTP binding
HPY14_RS03505	COG0193	aminoacyl-tRNA hydrolase activity
HPY14_RS03510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY14_RS03515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY14_RS03520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY14_RS03525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY14_RS03530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY14_RS03535	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY14_RS03545	COG2912	Transglutaminase-like superfamily
HPY14_RS03550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY14_RS03555	COG0737	Belongs to the 5'-nucleotidase family
HPY14_RS03560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY14_RS03565	COG2233	PERMEase
HPY14_RS03585	COG1393	Belongs to the ArsC family
HPY14_RS03590	COG4783	chaperone-mediated protein folding
HPY14_RS03610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY14_RS03625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY14_RS03635	COG1876	peptidase activity
HPY14_RS03645	COG1393	Belongs to the ArsC family
HPY14_RS03665	COG2837	iron assimilation
HPY14_RS03670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY14_RS03675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY14_RS03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY14_RS03685	COG1334	flagellar protein FlaG
HPY14_RS03690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY14_RS03700	COG1516	flagellar protein fliS
HPY14_RS03710	COG4191	Histidine kinase
HPY14_RS03720	COG1677	Flagellar hook-basal body complex protein FliE
HPY14_RS03730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY14_RS03735	COG1317	bacterial-type flagellum organization
HPY14_RS03760	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY14_RS03785	COG1987	bacterial-type flagellum assembly
HPY14_RS03790	COG1684	flagellar biosynthetic protein fliR
HPY14_RS03800	COG2840	Smr protein MutS2
HPY14_RS03805	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY14_RS03810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY14_RS03815	COG2860	membrane
HPY14_RS03820	COG3101	peptidyl-lysine hydroxylation
HPY14_RS03830	COG0431	NADPH-dependent FMN reductase
HPY14_RS03835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY14_RS03835	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY14_RS03840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY14_RS03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY14_RS03850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY14_RS03855	COG0735	belongs to the Fur family
HPY14_RS03865	COG0583	DNA-binding transcription factor activity
HPY14_RS03875	COG1346	cytolysis
HPY14_RS03890	COG0596	Alpha beta hydrolase
HPY14_RS03895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY14_RS03900	COG0033	Phosphoglucomutase
HPY14_RS03910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY14_RS03915	COG0372	Belongs to the citrate synthase family
HPY14_RS03920	COG2009	succinate dehydrogenase
HPY14_RS03925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY14_RS03930	COG1053	succinate dehydrogenase
HPY14_RS03940	COG0567	Dehydrogenase, E1 component
HPY14_RS03945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY14_RS03950	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY14_RS03960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY14_RS03965	COG1121	(ABC) transporter
HPY14_RS03970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY14_RS03975	COG4977	sequence-specific DNA binding
HPY14_RS03980	COG1918	ferrous iron import across plasma membrane
HPY14_RS04000	COG0018	arginyl-trna synthetase
HPY14_RS04010	COG1025	Belongs to the peptidase M16 family
HPY14_RS04015	COG2062	phosphohistidine phosphatase, SixA
HPY14_RS04045	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY14_RS04050	COG2198	Histidine kinase
HPY14_RS04050	COG0643	Histidine kinase
HPY14_RS04050	COG0784	Response regulator, receiver
HPY14_RS04055	COG2201	protein-glutamate methylesterase activity
HPY14_RS04060	COG1192	Involved in chromosome partitioning
HPY14_RS04070	COG0835	chemotaxis
HPY14_RS04080	COG4133	protoheme IX ABC transporter activity
HPY14_RS04085	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY14_RS04090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY14_RS04100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY14_RS04105	COG1138	Cytochrome C-type biogenesis protein
HPY14_RS04110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY14_RS04115	COG3088	subunit of a heme lyase
HPY14_RS04115	COG4235	cytochrome complex assembly
HPY14_RS04125	COG2853	Lipoprotein
HPY14_RS04145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY14_RS04150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY14_RS04155	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY14_RS04170	COG3083	sulfuric ester hydrolase activity
HPY14_RS04175	COG3082	Protein of unknown function (DUF1414)
HPY14_RS04180	COG3081	Nucleoid-associated protein
HPY14_RS04190	COG1757	Na H antiporter
HPY14_RS04195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY14_RS04200	COG2095	MarC family integral membrane protein
HPY14_RS04205	COG1454	alcohol dehydrogenase
HPY14_RS04205	COG1012	belongs to the aldehyde dehydrogenase family
HPY14_RS04215	COG0659	secondary active sulfate transmembrane transporter activity
HPY14_RS04220	COG1530	ribonuclease E activity
HPY14_RS04225	COG0564	pseudouridine synthase activity
HPY14_RS04230	COG0424	maF-like protein
HPY14_RS04235	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY14_RS04240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY14_RS04245	COG0416	fatty acid biosynthetic process
HPY14_RS04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY14_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
HPY14_RS04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY14_RS04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY14_RS04275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY14_RS04280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY14_RS04285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY14_RS04295	COG0084	hydrolase, TatD family'
HPY14_RS04300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY14_RS04300	COG1263	PTS System
HPY14_RS04310	COG0733	neurotransmitter:sodium symporter activity
HPY14_RS04325	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY14_RS04335	COG1940	carbohydrate kinase activity
HPY14_RS04340	COG0784	Response regulator, receiver
HPY14_RS04340	COG0835	chemotaxis
HPY14_RS04355	COG2226	methyltransferase
HPY14_RS04365	COG0676	glucose-6-phosphate 1-epimerase activity
HPY14_RS04370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY14_RS04375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY14_RS04385	COG3139	Protein of unknown function (DUF1315)
HPY14_RS04390	COG0252	asparaginase activity
HPY14_RS04395	COG0616	signal peptide processing
HPY14_RS04400	COG1902	pentaerythritol trinitrate reductase activity
HPY14_RS04400	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY14_RS04405	COG0788	formyltetrahydrofolate deformylase activity
HPY14_RS04415	COG1199	ATP-dependent helicase activity
HPY14_RS04420	COG1214	PFAM Peptidase M22, glycoprotease
HPY14_RS04435	COG0596	Alpha beta hydrolase
HPY14_RS04440	COG0318	PFAM AMP-dependent synthetase and ligase
HPY14_RS04445	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY14_RS04450	COG0705	Rhomboid family
HPY14_RS04460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY14_RS04465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY14_RS04470	COG0436	Aminotransferase
HPY14_RS04475	COG1169	isochorismate synthase
HPY14_RS04480	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY14_RS04485	COG0596	Alpha beta hydrolase
HPY14_RS04505	COG3135	benzoate transporter
HPY14_RS04530	COG3015	lipoprotein NlpE involved in copper resistance
HPY14_RS04535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY14_RS04540	COG2894	cell division
HPY14_RS04545	COG0850	regulation of cytokinetic process
HPY14_RS04550	COG3100	YcgL domain-containing protein
HPY14_RS04555	COG2951	lytic endotransglycosylase activity
HPY14_RS04565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY14_RS04570	COG3469	chitinase activity
HPY14_RS04570	COG3325	Belongs to the glycosyl hydrolase 18 family
HPY14_RS04575	COG3005	denitrification pathway
HPY14_RS04580	COG0243	molybdopterin cofactor binding
HPY14_RS04595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY14_RS04605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY14_RS04645	COG4589	Belongs to the CDS family
HPY14_RS04655	COG3300	MHYT domain
HPY14_RS04655	COG5001	Diguanylate cyclase
HPY14_RS04665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY14_RS04670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY14_RS04675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY14_RS04680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY14_RS04690	COG4191	Histidine kinase
HPY14_RS04700	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY14_RS04710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY14_RS04715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY14_RS04720	COG0776	regulation of translation
HPY14_RS04725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY14_RS04730	COG1555	photosystem II stabilization
HPY14_RS04735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY14_RS04740	COG0539	negative regulation of cytoplasmic translation
HPY14_RS04745	COG0776	regulation of translation
HPY14_RS04750	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY14_RS04755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY14_RS04765	COG0601	transmembrane transport
HPY14_RS04770	COG4239	(ABC) transporter, permease
HPY14_RS04775	COG0747	negative chemotaxis
HPY14_RS04780	COG0444	Belongs to the ABC transporter superfamily
HPY14_RS04785	COG4608	Belongs to the ABC transporter superfamily
HPY14_RS04810	COG0583	DNA-binding transcription factor activity
HPY14_RS04820	COG0686	Belongs to the AlaDH PNT family
HPY14_RS04830	COG1674	ftsk spoiiie
HPY14_RS04835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY14_RS04840	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY14_RS04845	COG2186	Transcriptional regulator
HPY14_RS04860	COG0537	adenosine 5'-monophosphoramidase activity
HPY14_RS04885	COG3150	esterase
HPY14_RS04890	COG1252	NADH dehydrogenase
HPY14_RS04910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY14_RS04920	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY14_RS04925	COG1136	(ABC) transporter
HPY14_RS04930	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY14_RS04940	COG0658	competence protein
HPY14_RS04940	COG2333	competence protein COMEC
HPY14_RS04945	COG1132	(ABC) transporter
HPY14_RS04950	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY14_RS04955	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY14_RS04960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY14_RS04965	COG2719	SpoVR family
HPY14_RS04970	COG2718	Belongs to the UPF0229 family
HPY14_RS04975	COG2766	serine protein kinase
HPY14_RS04980	COG3013	Belongs to the UPF0304 family
HPY14_RS04990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY14_RS04995	COG0840	transmembrane signaling receptor activity
HPY14_RS05005	COG1882	Formate acetyltransferase
HPY14_RS05030	COG4160	amino acid transport
HPY14_RS05035	COG0708	Exodeoxyribonuclease III
HPY14_RS05040	COG0840	transmembrane signaling receptor activity
HPY14_RS05050	COG3923	Primosomal replication protein n
HPY14_RS05055	COG0730	response to heat
HPY14_RS05060	COG1199	ATP-dependent helicase activity
HPY14_RS05065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY14_RS05070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY14_RS05075	COG3012	SEC-C Motif Domain Protein
HPY14_RS05080	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY14_RS05085	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY14_RS05090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY14_RS05095	COG0215	cysteine-tRNA ligase activity
HPY14_RS05100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY14_RS05105	COG0632	four-way junction helicase activity
HPY14_RS05115	COG1271	oxidase subunit
HPY14_RS05120	COG1294	oxidase, subunit
HPY14_RS05125	COG4890	Cyd operon protein YbgT
HPY14_RS05130	COG3790	cyd operon protein YbgE
HPY14_RS05135	COG0824	Thioesterase
HPY14_RS05140	COG0811	peptide transport
HPY14_RS05155	COG0823	Involved in the tonB-independent uptake of proteins
HPY14_RS05160	COG2885	chlorophyll binding
HPY14_RS05170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY14_RS05180	COG0784	Response regulator, receiver
HPY14_RS05180	COG5002	protein histidine kinase activity
HPY14_RS05190	COG1012	belongs to the aldehyde dehydrogenase family
HPY14_RS05195	COG3284	Transcriptional regulator
HPY14_RS05200	COG4628	conserved protein (DUF2132)
HPY14_RS05210	COG0415	Belongs to the DNA photolyase family
HPY14_RS05240	COG4409	exo-alpha-(2->6)-sialidase activity
HPY14_RS05245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY14_RS05250	COG1940	carbohydrate kinase activity
HPY14_RS05260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY14_RS05265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY14_RS05270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY14_RS05275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPY14_RS05280	COG1737	Transcriptional regulator
HPY14_RS05285	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY14_RS05290	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY14_RS05300	COG4932	domain protein
HPY14_RS05300	COG5492	domain, Protein
HPY14_RS05325	COG0596	Alpha beta hydrolase
HPY14_RS05335	COG3064	Membrane
HPY14_RS05435	COG4789	Type iii secretion
HPY14_RS05440	COG4792	protein secretion
HPY14_RS05470	COG3710	Transcriptional regulator
HPY14_RS05480	COG4790	Type iii secretion
HPY14_RS05560	COG0582	viral genome integration into host DNA
HPY14_RS05575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY14_RS05585	COG3008	intermembrane lipid transfer
HPY14_RS05585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY14_RS05590	COG2995	paraquat-inducible protein a
HPY14_RS05595	COG0668	transmembrane transport
HPY14_RS05615	COG1309	transcriptional regulator
HPY14_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
HPY14_RS05645	COG1960	acyl-CoA dehydrogenase activity
HPY14_RS05650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY14_RS05655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY14_RS05660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY14_RS05665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY14_RS05680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY14_RS05685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY14_RS05690	COG0297	glycogen (starch) synthase activity
HPY14_RS05710	COG3070	regulator of competence-specific genes
HPY14_RS05715	COG1609	Transcriptional regulator
HPY14_RS05725	COG0745	RESPONSE REGULATOR receiver
HPY14_RS05730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY14_RS05735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY14_RS05740	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY14_RS05745	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY14_RS05750	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HPY14_RS05755	COG1979	alcohol dehydrogenase
HPY14_RS05760	COG2207	Transcriptional regulator
HPY14_RS05785	COG1032	radical SAM domain protein
HPY14_RS05790	COG5001	Diguanylate cyclase
HPY14_RS05810	COG0583	DNA-binding transcription factor activity
HPY14_RS05815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY14_RS05825	COG2350	Protein conserved in bacteria
HPY14_RS05830	COG1607	acyl-coa hydrolase
HPY14_RS05845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY14_RS05850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY14_RS05860	COG2116	formate transmembrane transporter activity
HPY14_RS05870	COG4459	periplasmic nitrate reductase
HPY14_RS05875	COG3005	denitrification pathway
HPY14_RS05880	COG0243	molybdopterin cofactor binding
HPY14_RS05895	COG1227	inorganic diphosphatase activity
HPY14_RS05910	COG4172	Belongs to the ABC transporter superfamily
HPY14_RS05925	COG4168	peptide transport system, permease
HPY14_RS05935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY14_RS05940	COG1842	Phage shock protein A
HPY14_RS05955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY14_RS05970	COG2818	Glycosylase
HPY14_RS05975	COG0626	cystathionine gamma-synthase activity
HPY14_RS05985	COG0733	neurotransmitter:sodium symporter activity
HPY14_RS05990	COG0564	pseudouridine synthase activity
HPY14_RS05995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY14_RS06000	COG4136	ATPase activity
HPY14_RS06005	COG4135	transport system, permease component
HPY14_RS06010	COG4134	Bacterial extracellular solute-binding protein
HPY14_RS06020	COG3313	Fe-S protein
HPY14_RS06030	COG0842	Transport permease protein
HPY14_RS06035	COG1131	(ABC) transporter
HPY14_RS06040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY14_RS06045	COG0814	amino acid
HPY14_RS06055	COG2239	Acts as a magnesium transporter
HPY14_RS06060	COG0784	Response regulator, receiver
HPY14_RS06060	COG2205	protein histidine kinase activity
HPY14_RS06075	COG4934	collagen metabolic process
HPY14_RS06105	COG0840	transmembrane signaling receptor activity
HPY14_RS06115	COG5001	Diguanylate cyclase
HPY14_RS06115	COG2203	Gaf domain
HPY14_RS06115	COG3706	GGDEF domain
HPY14_RS06115	COG4251	negative regulation of phosphorylation
HPY14_RS06120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY14_RS06140	COG1061	Type III restriction enzyme res subunit
HPY14_RS06145	COG1187	pseudouridine synthase activity
HPY14_RS06150	COG2814	Major facilitator Superfamily
HPY14_RS06160	COG0702	epimerase
HPY14_RS06165	COG0534	Mate efflux family protein
HPY14_RS06170	COG4181	ATPase activity
HPY14_RS06185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY14_RS06195	COG1748	Saccharopine dehydrogenase
HPY14_RS06210	COG1538	Outer membrane efflux protein
HPY14_RS06230	COG0583	DNA-binding transcription factor activity
HPY14_RS06240	COG1451	nucleotide metabolic process
HPY14_RS06255	COG3063	Type IV pilus biogenesis stability protein PilW
HPY14_RS06260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY14_RS06280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY14_RS06295	COG3290	protein histidine kinase activity
HPY14_RS06300	COG4565	transcriptional regulatory protein
HPY14_RS06310	COG0835	chemotaxis
HPY14_RS06310	COG0784	Response regulator, receiver
HPY14_RS06355	COG1085	galactose-1-phosphate uridylyltransferase
HPY14_RS06360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY14_RS06365	COG2017	converts alpha-aldose to the beta-anomer
HPY14_RS06370	COG3706	GGDEF domain
HPY14_RS06375	COG2200	EAL domain
HPY14_RS06375	COG2199	diguanylate cyclase activity
HPY14_RS06390	COG3527	Alpha-acetolactate decarboxylase
HPY14_RS06405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY14_RS06415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY14_RS06455	COG1271	oxidase subunit
HPY14_RS06460	COG1294	oxidase, subunit
HPY14_RS06465	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY14_RS06465	COG1136	(ABC) transporter
HPY14_RS06470	COG1136	(ABC) transporter
HPY14_RS06470	COG0577	efflux transmembrane transporter activity
HPY14_RS06475	COG1136	(ABC) transporter
HPY14_RS06475	COG0577	efflux transmembrane transporter activity
HPY14_RS06500	COG2723	6-phospho-beta-galactosidase activity
HPY14_RS06505	COG1609	Transcriptional regulator
HPY14_RS06510	COG0251	oxidation-reduction process
HPY14_RS06515	COG2731	YhcH YjgK YiaL family protein
HPY14_RS06520	COG0584	glycerophosphoryl diester phosphodiesterase
HPY14_RS06525	COG1349	DNA-binding transcription factor activity
HPY14_RS06530	COG3842	ATPase activity
HPY14_RS06535	COG0395	ABC-type sugar transport system, permease component
HPY14_RS06540	COG1175	transmembrane transport
HPY14_RS06555	COG0811	peptide transport
HPY14_RS06560	COG0811	peptide transport
HPY14_RS06565	COG0848	biopolymer transport protein
HPY14_RS06570	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY14_RS06580	COG1793	dna ligase
HPY14_RS06590	COG0534	Mate efflux family protein
HPY14_RS06600	COG3001	Fructosamine kinase
HPY14_RS06610	COG0791	NLP P60 protein
HPY14_RS06615	COG0840	transmembrane signaling receptor activity
HPY14_RS06630	COG1940	carbohydrate kinase activity
HPY14_RS06640	COG0303	'Molybdopterin
HPY14_RS06645	COG0746	molybdenum cofactor guanylyltransferase activity
HPY14_RS06650	COG3842	ATPase activity
HPY14_RS06655	COG4662	Binding-protein-dependent transport system inner membrane component
HPY14_RS06665	COG2204	response regulator
HPY14_RS06670	COG3852	Histidine kinase
HPY14_RS06675	COG0488	(ABC) transporter
HPY14_RS06680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY14_RS06710	COG3383	formate dehydrogenase (NAD+) activity
HPY14_RS06710	COG0243	molybdopterin cofactor binding
HPY14_RS06715	COG0437	4 iron, 4 sulfur cluster binding
HPY14_RS06730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY14_RS06735	COG1666	GTP binding
HPY14_RS06740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY14_RS06755	COG2996	Protein conserved in bacteria
HPY14_RS06765	COG3008	intermembrane lipid transfer
HPY14_RS06770	COG2995	paraquat-inducible protein a
HPY14_RS06775	COG1132	(ABC) transporter
HPY14_RS06780	COG1956	GAF domain-containing protein
HPY14_RS06785	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY14_RS06800	COG0308	aminopeptidase N
HPY14_RS06815	COG0167	dihydroorotate dehydrogenase activity
HPY14_RS06825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY14_RS06825	COG0116	Belongs to the methyltransferase superfamily
HPY14_RS06850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY14_RS06855	COG1067	ATP-dependent peptidase activity
HPY14_RS06860	COG3120	sequence-specific DNA binding
HPY14_RS06890	COG3422	double-strand break repair
HPY14_RS06940	COG1073	alpha beta
HPY14_RS06940	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY14_RS06940	COG3064	Membrane
HPY14_RS06945	COG2994	toxin metabolic process
HPY14_RS06970	COG0784	Response regulator, receiver
HPY14_RS06970	COG2205	protein histidine kinase activity
HPY14_RS06985	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY14_RS07000	COG2010	Cytochrome c
HPY14_RS07010	COG2217	Heavy metal translocating P-type atpase
HPY14_RS07025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY14_RS07030	COG0589	response to stress
HPY14_RS07035	COG0037	tRNA processing
HPY14_RS07055	COG3842	ATPase activity
HPY14_RS07065	COG1177	transmembrane transport
HPY14_RS07075	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY14_RS07090	COG1115	amino acid carrier protein
HPY14_RS07095	COG1280	lysine exporter protein (LysE YggA)
HPY14_RS07140	COG3501	Rhs element vgr protein
HPY14_RS07150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY14_RS07155	COG0840	transmembrane signaling receptor activity
HPY14_RS07160	COG2814	Major facilitator Superfamily
HPY14_RS07165	COG1566	PFAM secretion protein HlyD family protein
HPY14_RS07170	COG1538	Outer membrane efflux protein
HPY14_RS07180	COG0513	Belongs to the DEAD box helicase family
HPY14_RS07190	COG0840	transmembrane signaling receptor activity
HPY14_RS07195	COG0840	transmembrane signaling receptor activity
HPY14_RS07200	COG0835	chemotaxis
HPY14_RS07205	COG2201	protein-glutamate methylesterase activity
HPY14_RS07215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY14_RS07220	COG0643	Histidine kinase
HPY14_RS07220	COG2198	Histidine kinase
HPY14_RS07220	COG0784	Response regulator, receiver
HPY14_RS07225	COG0643	Histidine kinase
HPY14_RS07225	COG2198	Histidine kinase
HPY14_RS07235	COG0745	RESPONSE REGULATOR receiver
HPY14_RS07250	COG0415	Belongs to the DNA photolyase family
HPY14_RS07255	COG0477	Major facilitator Superfamily
HPY14_RS07260	COG0583	DNA-binding transcription factor activity
HPY14_RS07270	COG0095	Lipoate-protein ligase
HPY14_RS07275	COG0443	Heat shock 70 kDa protein
HPY14_RS07285	COG1643	Atp-dependent helicase
HPY14_RS07315	COG0443	Heat shock 70 kDa protein
HPY14_RS07320	COG0443	Heat shock 70 kDa protein
HPY14_RS07325	COG3706	GGDEF domain
HPY14_RS07355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY14_RS07360	COG0602	queuosine metabolic process
HPY14_RS07365	COG0561	phosphatase activity
HPY14_RS07375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY14_RS07380	COG4597	amino acid ABC transporter
HPY14_RS07385	COG0765	amino acid transport
HPY14_RS07390	COG1126	abc transporter atp-binding protein
HPY14_RS07395	COG0670	Belongs to the BI1 family
HPY14_RS07400	COG2920	part of a sulfur-relay system
HPY14_RS07405	COG1254	Belongs to the acylphosphatase family
HPY14_RS07410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY14_RS07415	COG3706	GGDEF domain
HPY14_RS07425	COG3437	response regulator, receiver
HPY14_RS07425	COG2205	protein histidine kinase activity
HPY14_RS07425	COG4999	Histidine kinase
HPY14_RS07425	COG3850	Histidine kinase
HPY14_RS07430	COG3437	response regulator, receiver
HPY14_RS07435	COG0625	glutathione transferase activity
HPY14_RS07445	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY14_RS07455	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY14_RS07485	COG0372	Belongs to the citrate synthase family
HPY14_RS07490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY14_RS07515	COG0583	DNA-binding transcription factor activity
HPY14_RS07520	COG4771	TonB-dependent receptor
HPY14_RS07545	COG1566	PFAM secretion protein HlyD family protein
HPY14_RS07565	COG1129	ABC transporter
HPY14_RS07590	COG0745	RESPONSE REGULATOR receiver
HPY14_RS07595	COG2205	protein histidine kinase activity
HPY14_RS07600	COG3713	MltA-interacting MipA family protein
HPY14_RS07605	COG2990	Protein conserved in bacteria
HPY14_RS07615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY14_RS07615	COG4191	Histidine kinase
HPY14_RS07620	COG0471	metal ion transport
HPY14_RS07630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY14_RS07645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY14_RS07655	COG3768	UPF0283 membrane protein
HPY14_RS07660	COG3106	COG3106 Predicted ATPase
HPY14_RS07675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY14_RS07680	COG0494	nUDIX hydrolase
HPY14_RS07685	COG0814	amino acid
HPY14_RS07690	COG1760	l-serine dehydratase
HPY14_RS07695	COG0720	synthase
HPY14_RS07700	COG0840	transmembrane signaling receptor activity
HPY14_RS07705	COG0017	Asparaginyl-tRNA synthetase
HPY14_RS07710	COG0351	phosphomethylpyrimidine kinase
HPY14_RS07715	COG3437	response regulator, receiver
HPY14_RS07715	COG2770	Histidine kinase
HPY14_RS07720	COG1448	Aminotransferase
HPY14_RS07735	COG0840	transmembrane signaling receptor activity
HPY14_RS07740	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY14_RS07745	COG2943	transferase activity, transferring hexosyl groups
HPY14_RS07750	COG1609	Transcriptional regulator
HPY14_RS07755	COG3394	polysaccharide catabolic process
HPY14_RS07760	COG1486	melibiose metabolic process
HPY14_RS07765	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPY14_RS07775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPY14_RS07780	COG0726	polysaccharide deacetylase
HPY14_RS07785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY14_RS07790	COG1846	Transcriptional regulator
HPY14_RS07815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY14_RS07830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY14_RS07835	COG3108	Peptidase M15
HPY14_RS07870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY14_RS07880	COG2814	Major facilitator Superfamily
HPY14_RS07900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY14_RS07905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY14_RS07910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY14_RS07955	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY14_RS07960	COG4139	cobalamin transport
HPY14_RS07965	COG2988	succinylglutamate desuccinylase activity
HPY14_RS07980	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY14_RS07985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY14_RS07990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY14_RS08000	COG2925	Exonuclease
HPY14_RS08005	COG1380	Effector of murein hydrolase LrgA
HPY14_RS08010	COG1346	cytolysis
HPY14_RS08040	COG0776	regulation of translation
HPY14_RS08045	COG0072	phenylalanine-tRNA ligase activity
HPY14_RS08045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY14_RS08050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY14_RS08090	COG0322	excinuclease ABC activity
HPY14_RS08095	COG2197	response regulator
HPY14_RS08100	COG0417	DNA replication proofreading
HPY14_RS08105	COG5001	Diguanylate cyclase
HPY14_RS08115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY14_RS08120	COG3099	Belongs to the UPF0263 family
HPY14_RS08135	COG1228	amidohydrolase
HPY14_RS08140	COG0010	Belongs to the arginase family
HPY14_RS08145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY14_RS08150	COG2986	histidine ammonia-lyase
HPY14_RS08170	COG0277	FAD linked oxidase domain protein
HPY14_RS08170	COG0247	lactate metabolic process
HPY14_RS08185	COG2885	chlorophyll binding
HPY14_RS08205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY14_RS08215	COG0281	malic enzyme
HPY14_RS08225	COG2949	membrane
HPY14_RS08230	COG3706	GGDEF domain
HPY14_RS08235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY14_RS08245	COG0492	ferredoxin-NADP+ reductase activity
HPY14_RS08250	COG4988	ABC transporter
HPY14_RS08255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY14_RS08260	COG1187	pseudouridine synthase activity
HPY14_RS08265	COG0009	L-threonylcarbamoyladenylate synthase
HPY14_RS08270	COG0613	PHP domain protein
HPY14_RS08280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY14_RS08285	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY14_RS08290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY14_RS08295	COG0134	indole-3-glycerol-phosphate synthase activity
HPY14_RS08295	COG0135	phosphoribosylanthranilate isomerase activity
HPY14_RS08300	COG0133	tryptophan synthase activity
HPY14_RS08305	COG0159	tryptophan synthase activity
HPY14_RS08315	COG1435	thymidine kinase activity
HPY14_RS08320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY14_RS08325	COG1801	Protein of unknown function DUF72
HPY14_RS08330	COG4106	trans-aconitate 2-methyltransferase activity
HPY14_RS08335	COG0500	methyltransferase
HPY14_RS08340	COG0189	ligase activity
HPY14_RS08340	COG4067	protein conserved in archaea
HPY14_RS08355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY14_RS08365	COG3852	Histidine kinase
HPY14_RS08380	COG3070	regulator of competence-specific genes
HPY14_RS08390	COG2431	L-lysine efflux transmembrane transporter activity
HPY14_RS08400	COG0076	glutamate decarboxylase activity
HPY14_RS08405	COG1737	Transcriptional regulator
HPY14_RS08410	COG1454	alcohol dehydrogenase
HPY14_RS08410	COG1012	belongs to the aldehyde dehydrogenase family
HPY14_RS08415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY14_RS08420	COG3273	potassium ion transport
HPY14_RS08420	COG2985	domain, Protein
HPY14_RS08425	COG0542	response to heat
HPY14_RS08430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY14_RS08435	COG1278	Cold shock
HPY14_RS08445	COG1187	pseudouridine synthase activity
HPY14_RS08450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY14_RS08450	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY14_RS08455	COG0107	imidazoleglycerol-phosphate synthase activity
HPY14_RS08460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY14_RS08465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY14_RS08470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY14_RS08470	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY14_RS08475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY14_RS08480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY14_RS08485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY14_RS08490	COG1757	Na H antiporter
HPY14_RS08495	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY14_RS08500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY14_RS08505	COG0482	sulfurtransferase activity
HPY14_RS08510	COG2915	High frequency lysogenization protein hflD homolog
HPY14_RS08515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY14_RS08525	COG2268	Band 7 protein
HPY14_RS08535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY14_RS08550	COG0300	oxidoreductase activity
HPY14_RS08560	COG0501	Belongs to the peptidase M48B family
HPY14_RS08570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY14_RS08575	COG2226	methyltransferase
HPY14_RS08580	COG0156	8-amino-7-oxononanoate synthase activity
HPY14_RS08585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY14_RS08590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY14_RS08595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY14_RS08600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY14_RS08605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY14_RS08610	COG0653	protein targeting
HPY14_RS08615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY14_RS08620	COG2203	Gaf domain
HPY14_RS08620	COG2199	diguanylate cyclase activity
HPY14_RS08630	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY14_RS08640	COG4628	conserved protein (DUF2132)
HPY14_RS08645	COG3092	negative regulation of chromosome organization
HPY14_RS08650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY14_RS08655	COG0857	belongs to the CobB CobQ family
HPY14_RS08655	COG0280	phosphate acetyltransferase
HPY14_RS08660	COG0435	Glutathione S-transferase
HPY14_RS08665	COG4608	Belongs to the ABC transporter superfamily
HPY14_RS08670	COG0444	Belongs to the ABC transporter superfamily
HPY14_RS08675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY14_RS08680	COG0601	transmembrane transport
HPY14_RS08700	COG2204	response regulator
HPY14_RS08705	COG5001	Diguanylate cyclase
HPY14_RS08705	COG3300	MHYT domain
HPY14_RS08710	COG4191	Histidine kinase
HPY14_RS08715	COG5002	protein histidine kinase activity
HPY14_RS08725	COG2201	protein-glutamate methylesterase activity
HPY14_RS08740	COG0009	L-threonylcarbamoyladenylate synthase
HPY14_RS08755	COG1881	PFAM PEBP family protein
HPY14_RS08780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS08785	COG3716	PTS system mannose fructose sorbose family IID component
HPY14_RS08795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY14_RS08800	COG2222	sugar isomerase
HPY14_RS08810	COG1349	DNA-binding transcription factor activity
HPY14_RS08815	COG1349	DNA-binding transcription factor activity
HPY14_RS08830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY14_RS08835	COG0640	Transcriptional regulator
HPY14_RS08845	COG3706	GGDEF domain
HPY14_RS08865	COG1946	Acyl-CoA thioesterase
HPY14_RS08870	COG1522	sequence-specific DNA binding
HPY14_RS08880	COG0616	signal peptide processing
HPY14_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
HPY14_RS08890	COG2983	Belongs to the UPF0260 family
HPY14_RS08900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY14_RS08905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY14_RS08915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY14_RS08920	COG2832	Protein of unknown function (DUF454)
HPY14_RS08925	COG0745	RESPONSE REGULATOR receiver
HPY14_RS08930	COG0583	DNA-binding transcription factor activity
HPY14_RS08935	COG0778	Nitroreductase
HPY14_RS08940	COG1024	Enoyl-CoA hydratase
HPY14_RS08940	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY14_RS08945	COG0183	Belongs to the thiolase family
HPY14_RS08960	COG2067	long-chain fatty acid transport protein
HPY14_RS08970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY14_RS08975	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY14_RS08980	COG2982	Protein involved in outer membrane biogenesis
HPY14_RS08985	COG0572	uridine kinase
HPY14_RS08990	COG0489	protein tyrosine kinase activity
HPY14_RS08995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY14_RS08995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY14_RS09010	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY14_RS09020	COG0517	IMP dehydrogenase activity
HPY14_RS09020	COG0617	tRNA 3'-terminal CCA addition
HPY14_RS09020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY14_RS09025	COG2199	diguanylate cyclase activity
HPY14_RS09030	COG0314	molybdopterin synthase activity
HPY14_RS09035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY14_RS09040	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY14_RS09045	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY14_RS09050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY14_RS09055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY14_RS09060	COG2198	Histidine kinase
HPY14_RS09065	COG2204	response regulator
HPY14_RS09070	COG0556	nucleotide-excision repair
HPY14_RS09080	COG4657	Part of a membrane complex involved in electron transport
HPY14_RS09085	COG2878	Part of a membrane complex involved in electron transport
HPY14_RS09090	COG4656	Part of a membrane complex involved in electron transport
HPY14_RS09105	COG4660	Part of a membrane complex involved in electron transport
HPY14_RS09110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY14_RS09115	COG0346	lactoylglutathione lyase activity
HPY14_RS09130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY14_RS09135	COG2056	Na+-H+ antiporter family
HPY14_RS09140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY14_RS09145	COG1286	toxin biosynthetic process
HPY14_RS09150	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY14_RS09155	COG0285	dihydrofolate synthase activity
HPY14_RS09160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY14_RS09165	COG0101	tRNA pseudouridine synthase activity
HPY14_RS09180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY14_RS09180	COG2190	(PTS) system
HPY14_RS09180	COG1263	PTS System
HPY14_RS09185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY14_RS09190	COG1940	carbohydrate kinase activity
HPY14_RS09190	COG1846	Transcriptional regulator
HPY14_RS09195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY14_RS09195	COG4651	solute:proton antiporter activity
HPY14_RS09200	COG0367	asparagine synthase
HPY14_RS09210	COG3104	oligopeptide transport
HPY14_RS09215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY14_RS09220	COG0563	adenylate kinase activity
HPY14_RS09225	COG0326	Molecular chaperone. Has ATPase activity
HPY14_RS09230	COG3710	Transcriptional regulator
HPY14_RS09245	COG0622	Phosphoesterase
HPY14_RS09250	COG1090	epimerase
HPY14_RS09255	COG0300	oxidoreductase activity
HPY14_RS09260	COG3118	belongs to the thioredoxin family
HPY14_RS09265	COG0330	HflC and HflK could
HPY14_RS09270	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY14_RS09275	COG0789	Transcriptional regulator
HPY14_RS09280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY14_RS09290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY14_RS09295	COG3115	cell septum assembly
HPY14_RS09300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY14_RS09305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY14_RS09310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS09320	COG2190	(PTS) system
HPY14_RS09325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY14_RS09330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY14_RS09335	COG1702	phosphate starvation-inducible protein PhoH
HPY14_RS09345	COG4535	Mg2 and Co2 transporter CorC
HPY14_RS09350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY14_RS09355	COG2888	peptidyl-tyrosine sulfation
HPY14_RS09360	COG0495	leucyl-tRNA aminoacylation
HPY14_RS09365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY14_RS09370	COG1466	dna polymerase III delta subunit
HPY14_RS09375	COG0799	negative regulation of ribosome biogenesis
HPY14_RS09380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY14_RS09385	COG0768	penicillin binding
HPY14_RS09390	COG0772	Belongs to the SEDS family
HPY14_RS09395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY14_RS09400	COG1686	Belongs to the peptidase S11 family
HPY14_RS09405	COG2921	Belongs to the UPF0250 family
HPY14_RS09410	COG0321	lipoyl(octanoyl) transferase activity
HPY14_RS09415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY14_RS09425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY14_RS09450	COG1596	polysaccharide export
HPY14_RS09460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY14_RS09490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY14_RS09500	COG0438	transferase activity, transferring glycosyl groups
HPY14_RS09510	COG0438	transferase activity, transferring glycosyl groups
HPY14_RS09540	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY14_RS09545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY14_RS09550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY14_RS09555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY14_RS09585	COG0366	Alpha amylase catalytic
HPY14_RS09590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY14_RS09590	COG1263	PTS System
HPY14_RS09595	COG1609	Transcriptional regulator
HPY14_RS09600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY14_RS09605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY14_RS09610	COG2011	ABC-type metal ion transport system permease component
HPY14_RS09615	COG1464	Belongs to the NlpA lipoprotein family
HPY14_RS09620	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY14_RS09630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY14_RS09630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY14_RS09640	COG3706	GGDEF domain
HPY14_RS09645	COG1611	Belongs to the LOG family
HPY14_RS09650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY14_RS09655	COG2363	Small membrane protein
HPY14_RS09660	COG0583	DNA-binding transcription factor activity
HPY14_RS09665	COG0301	tRNA thio-modification
HPY14_RS09665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY14_RS09675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY14_RS09680	COG1722	exodeoxyribonuclease VII activity
HPY14_RS09685	COG0142	geranyltranstransferase activity
HPY14_RS09690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY14_RS09695	COG0564	pseudouridine synthase activity
HPY14_RS09700	COG3098	single-species biofilm formation
HPY14_RS09715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY14_RS09725	COG1671	Belongs to the UPF0178 family
HPY14_RS09730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY14_RS09735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY14_RS09740	COG0254	rRNA binding
HPY14_RS09745	COG1720	tRNA m6t6A37 methyltransferase activity
HPY14_RS09750	COG0442	prolyl-tRNA aminoacylation
HPY14_RS09770	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY14_RS09770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY14_RS09780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY14_RS09790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY14_RS09820	COG0484	heat shock protein binding
HPY14_RS09825	COG0443	Heat shock 70 kDa protein
HPY14_RS09835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY14_RS09840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY14_RS09845	COG0497	DNA recombination
HPY14_RS09850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY14_RS09855	COG2914	Belongs to the UPF0125 (RnfH) family
HPY14_RS09860	COG2867	negative regulation of translational initiation
HPY14_RS09865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY14_RS09895	COG0514	ATP-dependent DNA helicase (RecQ)
HPY14_RS09915	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY14_RS09920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY14_RS09925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY14_RS09945	COG3051	citrate lyase alpha subunit
HPY14_RS09950	COG2301	Belongs to the HpcH HpaI aldolase family
HPY14_RS09955	COG3052	prosthetic group binding
HPY14_RS09960	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY14_RS09970	COG3630	sodium ion export across plasma membrane
HPY14_RS09975	COG0511	ligase activity, forming carbon-carbon bonds
HPY14_RS09975	COG5016	pyruvate
HPY14_RS09980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY14_RS09990	COG4565	transcriptional regulatory protein
HPY14_RS10005	COG0583	DNA-binding transcription factor activity
HPY14_RS10015	COG1115	amino acid carrier protein
HPY14_RS10020	COG2977	Belongs to the P-Pant transferase superfamily
HPY14_RS10025	COG1120	ATPase activity
HPY14_RS10030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY14_RS10035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY14_RS10040	COG4592	Periplasmic binding protein
HPY14_RS10050	COG1028	Short-chain dehydrogenase reductase Sdr
HPY14_RS10055	COG1169	isochorismate synthase
HPY14_RS10060	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY14_RS10065	COG1535	isochorismatase
HPY14_RS10065	COG3433	isochorismatase activity
HPY14_RS10070	COG1584	GPR1 FUN34 yaaH family protein
HPY14_RS10080	COG0519	Catalyzes the synthesis of GMP from XMP
HPY14_RS10080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY14_RS10085	COG0516	GMP reductase activity
HPY14_RS10085	COG0517	IMP dehydrogenase activity
HPY14_RS10090	COG1570	exodeoxyribonuclease VII activity
HPY14_RS10105	COG1160	GTP binding
HPY14_RS10110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY14_RS10115	COG2976	Protein conserved in bacteria
HPY14_RS10120	COG0124	histidyl-tRNA synthetase
HPY14_RS10125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY14_RS10135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPY14_RS10140	COG0105	UTP biosynthetic process
HPY14_RS10145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY14_RS10150	COG2975	iron-sulfur cluster assembly
HPY14_RS10155	COG0633	Ferredoxin
HPY14_RS10160	COG0443	Heat shock 70 kDa protein
HPY14_RS10175	COG0822	iron-sulfur transferase activity
HPY14_RS10185	COG1959	2 iron, 2 sulfur cluster binding
HPY14_RS10195	COG0483	inositol monophosphate 1-phosphatase activity
HPY14_RS10200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY14_RS10205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY14_RS10210	COG1862	Preprotein translocase
HPY14_RS10220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY14_RS10225	COG0517	IMP dehydrogenase activity
HPY14_RS10235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY14_RS10240	COG0583	DNA-binding transcription factor activity
HPY14_RS10245	COG0450	alkyl hydroperoxide reductase
HPY14_RS10250	COG3142	Participates in the control of copper homeostasis
HPY14_RS10265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY14_RS10270	COG0581	inorganic phosphate transmembrane transporter activity
HPY14_RS10280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY14_RS10285	COG0248	Ppx GppA phosphatase
HPY14_RS10295	COG5002	protein histidine kinase activity
HPY14_RS10300	COG0745	RESPONSE REGULATOR receiver
HPY14_RS10315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY14_RS10360	COG0542	response to heat
HPY14_RS10370	COG0564	pseudouridine synthase activity
HPY14_RS10375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY14_RS10380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY14_RS10385	COG0077	Prephenate dehydratase
HPY14_RS10385	COG1605	Chorismate mutase
HPY14_RS10390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY14_RS10395	COG5001	Diguanylate cyclase
HPY14_RS10405	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY14_RS10415	COG0488	(ABC) transporter
HPY14_RS10425	COG1605	Chorismate mutase
HPY14_RS10425	COG0287	Prephenate dehydrogenase
HPY14_RS10430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY14_RS10435	COG3275	phosphorelay sensor kinase activity
HPY14_RS10440	COG3279	Response regulator of the LytR AlgR family
HPY14_RS10450	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY14_RS10455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY14_RS10470	COG1966	Carbon starvation protein
HPY14_RS10475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY14_RS10480	COG1047	Peptidyl-prolyl cis-trans
HPY14_RS10485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY14_RS10495	COG0196	riboflavin kinase activity
HPY14_RS10500	COG0728	peptidoglycan biosynthetic process
HPY14_RS10505	COG0268	Binds directly to 16S ribosomal RNA
HPY14_RS10510	COG0640	Transcriptional regulator
HPY14_RS10515	COG0583	DNA-binding transcription factor activity
HPY14_RS10520	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY14_RS10530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY14_RS10535	COG0730	response to heat
HPY14_RS10540	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY14_RS10545	COG0494	nUDIX hydrolase
HPY14_RS10550	COG3066	DNA modification
HPY14_RS10555	COG0667	Aldo Keto reductase
HPY14_RS10565	COG2204	response regulator
HPY14_RS10570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY14_RS10590	COG0513	Belongs to the DEAD box helicase family
HPY14_RS10615	COG3153	acetyltransferase
HPY14_RS10620	COG3154	lipid carrier protein
HPY14_RS10630	COG0826	peptidase U32
HPY14_RS10635	COG0826	peptidase U32
HPY14_RS10655	COG1185	polyribonucleotide nucleotidyltransferase activity
HPY14_RS10660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY14_RS10670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY14_RS10675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY14_RS10680	COG0195	Participates in both transcription termination and antitermination
HPY14_RS10685	COG0779	Required for maturation of 30S ribosomal subunits
HPY14_RS10700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY14_RS10710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY14_RS10715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY14_RS10720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY14_RS10725	COG1534	Rna-binding protein
HPY14_RS10730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY14_RS10735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY14_RS10740	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY14_RS10745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY14_RS10750	COG0739	heme binding
HPY14_RS10765	COG0316	Belongs to the HesB IscA family
HPY14_RS10770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY14_RS10775	COG0628	permease
HPY14_RS10780	COG2813	Specifically methylates the guanine in position
HPY14_RS10785	COG2205	protein histidine kinase activity
HPY14_RS10785	COG0784	Response regulator, receiver
HPY14_RS10790	COG0747	negative chemotaxis
HPY14_RS10795	COG0601	transmembrane transport
HPY14_RS10800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY14_RS10805	COG0444	Belongs to the ABC transporter superfamily
HPY14_RS10810	COG4608	Belongs to the ABC transporter superfamily
HPY14_RS10820	COG2971	BadF BadG BcrA BcrD
HPY14_RS10835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY14_RS10840	COG3842	ATPase activity
HPY14_RS10850	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY14_RS10855	COG0004	ammonium transporteR
HPY14_RS10860	COG0347	Belongs to the P(II) protein family
HPY14_RS10865	COG3112	Uncharacterised protein family (UPF0231)
HPY14_RS10870	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY14_RS10875	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY14_RS10880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY14_RS10885	COG1643	Atp-dependent helicase
HPY14_RS10895	COG1489	DNA binding
HPY14_RS10905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY14_RS10915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY14_RS10920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY14_RS10925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY14_RS10930	COG0842	Transport permease protein
HPY14_RS10935	COG1131	(ABC) transporter
HPY14_RS10940	COG0659	secondary active sulfate transmembrane transporter activity
HPY14_RS10945	COG0288	reversible hydration of carbon dioxide
HPY14_RS10960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY14_RS10965	COG3107	peptidoglycan biosynthetic process
HPY14_RS10970	COG0792	nuclease activity
HPY14_RS10975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY14_RS10980	COG2823	Periplasmic or secreted lipoprotein
HPY14_RS10985	COG2969	positive regulation of protein catabolic process
HPY14_RS10990	COG0625	glutathione transferase activity
HPY14_RS10995	COG2857	Cytochrome c1
HPY14_RS11000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY14_RS11005	COG0723	plastoquinol--plastocyanin reductase activity
HPY14_RS11010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY14_RS11015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY14_RS11020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY14_RS11030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY14_RS11035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY14_RS11040	COG0335	large ribosomal subunit rRNA binding
HPY14_RS11045	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY14_RS11050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY14_RS11055	COG0228	four-way junction DNA binding
HPY14_RS11060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY14_RS11065	COG4137	Cytochrome C assembly protein
HPY14_RS11070	COG4536	flavin adenine dinucleotide binding
HPY14_RS11075	COG1854	S-ribosylhomocysteine lyase activity
HPY14_RS11080	COG2918	glutathione biosynthetic process
HPY14_RS11085	COG0612	Peptidase, M16
HPY14_RS11090	COG1238	metal cluster binding
HPY14_RS11100	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY14_RS11105	COG0511	ligase activity, forming carbon-carbon bonds
HPY14_RS11105	COG5016	pyruvate
HPY14_RS11110	COG3630	sodium ion export across plasma membrane
HPY14_RS11155	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY14_RS11160	COG0527	aspartate kinase activity
HPY14_RS11165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY14_RS11170	COG2137	regulation of response to DNA damage stimulus
HPY14_RS11175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY14_RS11185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY14_RS11190	COG4208	sulfate ABC transporter
HPY14_RS11210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY14_RS11215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY14_RS11225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY14_RS11230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY14_RS11235	COG0585	pseudouridine synthase activity
HPY14_RS11240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY14_RS11245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY14_RS11250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY14_RS11255	COG1968	undecaprenyl-diphosphatase activity
HPY14_RS11260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY14_RS11265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY14_RS11270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY14_RS11280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY14_RS11285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY14_RS11290	COG1610	YqeY-like protein
HPY14_RS11295	COG0358	DNA primase activity
HPY14_RS11425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY14_RS11430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY14_RS11435	COG1349	DNA-binding transcription factor activity
HPY14_RS11455	COG1279	arginine transmembrane transporter activity
HPY14_RS11460	COG0668	transmembrane transport
HPY14_RS11465	COG0191	fructose-bisphosphate aldolase activity
HPY14_RS11470	COG0126	phosphoglycerate kinase activity
HPY14_RS11475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY14_RS11480	COG4771	TonB-dependent receptor
HPY14_RS11485	COG0583	DNA-binding transcription factor activity
HPY14_RS11490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY14_RS11495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY14_RS11500	COG3091	SprT-like family
HPY14_RS11505	COG2356	endonuclease I
HPY14_RS11510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY14_RS11515	COG0189	ligase activity
HPY14_RS11520	COG1678	Uncharacterized ACR, COG1678
HPY14_RS11525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY14_RS11530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY14_RS11550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY14_RS11555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY14_RS11560	COG0762	integral membrane protein
HPY14_RS11575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY14_RS11580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY14_RS11585	COG2066	Belongs to the glutaminase family
HPY14_RS11590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY14_RS11595	COG1194	a g-specific adenine glycosylase
HPY14_RS11600	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY14_RS11605	COG0741	lytic transglycosylase activity
HPY14_RS11660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY14_RS11665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY14_RS11670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY14_RS11675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY14_RS11680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY14_RS11685	COG2967	ApaG domain
HPY14_RS11690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY14_RS11700	COG3610	response to peptide
HPY14_RS11705	COG2966	Psort location CytoplasmicMembrane, score
HPY14_RS11710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY14_RS11715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY14_RS11720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY14_RS11725	COG0142	geranyltranstransferase activity
HPY14_RS11730	COG0531	amino acid
HPY14_RS11735	COG0039	L-malate dehydrogenase activity
HPY14_RS11740	COG1438	arginine binding
HPY14_RS11745	COG2358	TRAP transporter, solute receptor (TAXI family
HPY14_RS11755	COG0589	response to stress
HPY14_RS11775	COG2235	arginine
HPY14_RS11780	COG0312	modulator of DNA gyrase
HPY14_RS11785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY14_RS11790	COG3164	Protein of unknown function
HPY14_RS11795	COG1530	ribonuclease E activity
HPY14_RS11800	COG0424	maF-like protein
HPY14_RS11805	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY14_RS11810	COG1792	Involved in formation and maintenance of cell shape
HPY14_RS11815	COG1077	Cell shape determining protein MreB Mrl
HPY14_RS11860	COG1459	type II secretion system
HPY14_RS11865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY14_RS11875	COG3409	Peptidoglycan-binding domain 1 protein
HPY14_RS11875	COG3267	Type II secretory pathway component ExeA
HPY14_RS11900	COG2200	EAL domain
HPY14_RS11900	COG2199	diguanylate cyclase activity
HPY14_RS11905	COG0629	single-stranded DNA binding
HPY14_RS11920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY14_RS11930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY14_RS11935	COG0527	aspartate kinase activity
HPY14_RS11940	COG0646	methionine synthase
HPY14_RS11940	COG1410	methionine synthase
HPY14_RS12010	COG0175	sulfate reduction
HPY14_RS12015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPY14_RS12020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY14_RS12045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY14_RS12050	COG0735	belongs to the Fur family
HPY14_RS12065	COG0166	Belongs to the GPI family
HPY14_RS12070	COG0432	Pfam Uncharacterised protein family UPF0047
HPY14_RS12075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY14_RS12090	COG0359	binds to the 23S rRNA
HPY14_RS12095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY14_RS12100	COG2965	DNA replication, synthesis of RNA primer
HPY14_RS12105	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY14_RS12115	COG2906	2 iron, 2 sulfur cluster binding
HPY14_RS12120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY14_RS12125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY14_RS12130	COG0049	tRNA binding
HPY14_RS12145	COG2923	Belongs to the DsrF TusC family
HPY14_RS12150	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY14_RS12155	COG2964	Protein conserved in bacteria
HPY14_RS12160	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY14_RS12170	COG2900	Belongs to the SlyX family
HPY14_RS12175	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY14_RS12180	COG0330	HflC and HflK could
HPY14_RS12185	COG0330	HflC and HflK could
HPY14_RS12190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY14_RS12195	COG1923	regulation of RNA biosynthetic process
HPY14_RS12200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY14_RS12205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY14_RS12215	COG0802	atpase or kinase
HPY14_RS12220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY14_RS12270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY14_RS12275	COG1162	GTPase activity
HPY14_RS12280	COG0688	phosphatidylethanolamine metabolic process
HPY14_RS12285	COG0471	metal ion transport
HPY14_RS12295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY14_RS12300	COG4942	peptidase
HPY14_RS12315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY14_RS12320	COG2816	NAD+ diphosphatase activity
HPY14_RS12325	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY14_RS12335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY14_RS12340	COG0085	RNA polymerase activity
HPY14_RS12345	COG0222	ribosome binding
HPY14_RS12350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY14_RS12360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY14_RS12365	COG0250	Participates in transcription elongation, termination and antitermination
HPY14_RS12370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY14_RS12375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY14_RS12400	COG1072	(Pantothenic acid kinase))
HPY14_RS12410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY14_RS12420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY14_RS12465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY14_RS12480	COG3118	belongs to the thioredoxin family
HPY14_RS12485	COG0513	Belongs to the DEAD box helicase family
HPY14_RS12490	COG0248	Ppx GppA phosphatase
HPY14_RS12495	COG0784	Response regulator, receiver
HPY14_RS12495	COG2205	protein histidine kinase activity
HPY14_RS12500	COG2814	Major facilitator Superfamily
HPY14_RS12515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY14_RS12520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY14_RS12525	COG0511	ligase activity, forming carbon-carbon bonds
HPY14_RS12530	COG0439	Biotin carboxylase
HPY14_RS12535	COG2264	protein methyltransferase activity
HPY14_RS12540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY14_RS12545	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY14_RS12575	COG0129	dihydroxy-acid dehydratase activity
HPY14_RS12580	COG3265	gluconokinase activity
HPY14_RS12590	COG0800	Aldolase
HPY14_RS12610	COG0840	transmembrane signaling receptor activity
HPY14_RS12615	COG1982	Orn Lys Arg decarboxylase major
HPY14_RS12620	COG0531	amino acid
HPY14_RS12630	COG3710	Transcriptional regulator
HPY14_RS12635	COG0789	Transcriptional regulator
HPY14_RS12650	COG0151	Belongs to the GarS family
HPY14_RS12660	COG0776	regulation of translation
HPY14_RS12665	COG1253	flavin adenine dinucleotide binding
HPY14_RS12700	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY14_RS12705	COG3068	Protein conserved in bacteria
HPY14_RS12715	COG1573	uracil-dna glycosylase
HPY14_RS12720	COG0668	transmembrane transport
HPY14_RS12725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY14_RS12735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY14_RS12790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY14_RS12800	COG2089	acid synthase
HPY14_RS12810	COG1083	cytidylyl-transferase
HPY14_RS12815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPY14_RS12820	COG1086	Polysaccharide biosynthesis protein
HPY14_RS12825	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY14_RS12835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPY14_RS12845	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPY14_RS12850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY14_RS12880	COG0859	PFAM glycosyl transferase family 9
HPY14_RS12890	COG1519	Transferase
HPY14_RS12915	COG3642	lipopolysaccharide core region biosynthetic process
HPY14_RS12920	COG0859	PFAM glycosyl transferase family 9
HPY14_RS12925	COG0463	Glycosyl transferase, family 2
HPY14_RS12930	COG0859	PFAM glycosyl transferase family 9
HPY14_RS12935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY14_RS12940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY14_RS12950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY14_RS12955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY14_RS12960	COG2003	Belongs to the UPF0758 family
HPY14_RS12970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY14_RS12980	COG1309	transcriptional regulator
HPY14_RS12985	COG1560	Kdo2-lipid A biosynthetic process
HPY14_RS12990	COG1560	Kdo2-lipid A biosynthetic process
HPY14_RS12995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY14_RS13000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY14_RS13005	COG1561	YicC-like family, N-terminal region
HPY14_RS13010	COG2862	Uncharacterized protein family, UPF0114
HPY14_RS13015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY14_RS13015	COG1263	PTS System
HPY14_RS13020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY14_RS13035	COG0514	ATP-dependent DNA helicase (RecQ)
HPY14_RS13040	COG2962	Rard protein
HPY14_RS13045	COG0405	Gamma-glutamyltransferase
HPY14_RS13055	COG1280	lysine exporter protein (LysE YggA)
HPY14_RS13060	COG0210	DNA helicase
HPY14_RS13070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY14_RS13075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY14_RS13125	COG1196	nuclear chromosome segregation
HPY14_RS13135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY14_RS13145	COG0747	negative chemotaxis
HPY14_RS13195	COG1309	transcriptional regulator
HPY14_RS13200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY14_RS13205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY14_RS13210	COG2960	long-chain fatty acid transporting porin activity
HPY14_RS13215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY14_RS13220	COG0583	DNA-binding transcription factor activity
HPY14_RS13290	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY14_RS13295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY14_RS13300	COG1739	Uncharacterized protein family UPF0029
HPY14_RS13305	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY14_RS13305	COG1024	Enoyl-CoA hydratase
HPY14_RS13310	COG0183	Belongs to the thiolase family
HPY14_RS13315	COG0583	DNA-binding transcription factor activity
HPY14_RS13320	COG2814	Major facilitator Superfamily
HPY14_RS13330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY14_RS13335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY14_RS13340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY14_RS13345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY14_RS13350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY14_RS13355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY14_RS13365	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY14_RS13370	COG3312	ion transport
HPY14_RS13375	COG1475	DNA binding
HPY14_RS13380	COG1192	Involved in chromosome partitioning
HPY14_RS13385	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY14_RS13390	COG0445	tRNA wobble uridine modification
HPY14_RS13395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY14_RS13400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY14_RS13405	COG0706	membrane insertase activity
HPY14_RS13415	COG0594	ribonuclease P activity
HPY14_RS13420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY14_RS13425	COG1126	abc transporter atp-binding protein
HPY14_RS13470	COG0217	transcriptional regulatory protein
HPY14_RS13475	COG2084	Dehydrogenase
HPY14_RS13490	COG2909	trisaccharide binding
HPY14_RS13495	COG0058	SHG alpha-glucan phosphorylase activity
HPY14_RS13500	COG1640	4-alpha-glucanotransferase
HPY14_RS13505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY14_RS13515	COG3501	Rhs element vgr protein
HPY14_RS13550	COG0471	metal ion transport
HPY14_RS13555	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY14_RS13600	COG0671	phosphoesterase, PA-phosphatase related
HPY14_RS13605	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY14_RS13615	COG1999	signal sequence binding
HPY14_RS13630	COG0786	glutamate:sodium symporter activity
HPY14_RS13650	COG3706	GGDEF domain
HPY14_RS13665	COG0813	purine-nucleoside phosphorylase activity
HPY14_RS13670	COG3272	Protein of unknown function (DUF1722)
HPY14_RS13680	COG0415	Belongs to the DNA photolyase family
HPY14_RS13685	COG1388	LysM domain
HPY14_RS13685	COG1376	ErfK ybiS ycfS ynhG family protein
HPY14_RS13695	COG0513	Belongs to the DEAD box helicase family
HPY14_RS13700	COG1770	oligopeptidase
HPY14_RS13730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY14_RS13735	COG0573	inorganic phosphate transmembrane transporter activity
HPY14_RS13740	COG0581	inorganic phosphate transmembrane transporter activity
HPY14_RS13745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY14_RS13765	COG0659	secondary active sulfate transmembrane transporter activity
HPY14_RS13775	COG0739	heme binding
HPY14_RS13780	COG5001	Diguanylate cyclase
HPY14_RS13780	COG3300	MHYT domain
HPY14_RS13785	COG0583	DNA-binding transcription factor activity
HPY14_RS13790	COG2814	Major facilitator Superfamily
HPY14_RS13810	COG1301	dicarboxylic acid transport
HPY14_RS13820	COG1342	Belongs to the UPF0251 family
HPY14_RS13850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY14_RS13855	COG0673	inositol 2-dehydrogenase activity
HPY14_RS13865	COG2200	EAL domain
HPY14_RS13865	COG2771	luxR family
HPY14_RS13870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY14_RS13880	COG0564	pseudouridine synthase activity
HPY14_RS13990	COG1869	D-ribose catabolic process
HPY14_RS13995	COG1129	ABC transporter
HPY14_RS14000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY14_RS14005	COG1879	ABC-type sugar transport system periplasmic component
HPY14_RS14010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY14_RS14015	COG1609	Transcriptional regulator
HPY14_RS14025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY14_RS14035	COG0584	glycerophosphoryl diester phosphodiesterase
HPY14_RS14040	COG2271	Major facilitator Superfamily
HPY14_RS14075	COG0579	oxidoreductase
HPY14_RS14085	COG0242	peptide deformylase activity
HPY14_RS14100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS14105	COG1609	Transcriptional regulator
HPY14_RS14110	COG1017	nitric oxide dioxygenase activity
HPY14_RS14110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY14_RS14115	COG1320	monovalent cation:proton antiporter activity
HPY14_RS14120	COG2212	antiporter activity
HPY14_RS14140	COG2111	Na H antiporter
HPY14_RS14140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY14_RS14150	COG0589	response to stress
HPY14_RS14155	COG0814	amino acid
HPY14_RS14170	COG3530	Putative quorum-sensing-regulated virulence factor
HPY14_RS14180	COG5002	protein histidine kinase activity
HPY14_RS14180	COG5001	Diguanylate cyclase
HPY14_RS14185	COG1278	Cold shock
HPY14_RS14200	COG2304	oxidoreductase activity
HPY14_RS14220	COG0714	Associated with various cellular activities
HPY14_RS14225	COG0840	transmembrane signaling receptor activity
HPY14_RS14240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY14_RS14245	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY14_RS14255	COG3604	Transcriptional regulator
HPY14_RS14260	COG1017	nitric oxide dioxygenase activity
HPY14_RS14260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY14_RS14265	COG1278	Cold shock
HPY14_RS14270	COG3036	rescue of stalled ribosome
HPY14_RS14295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY14_RS14295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY14_RS14300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY14_RS14310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY14_RS14320	COG0516	GMP reductase activity
HPY14_RS14335	COG0513	Belongs to the DEAD box helicase family
HPY14_RS14340	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY14_RS14345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY14_RS14350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY14_RS14355	COG3437	response regulator, receiver
HPY14_RS14355	COG0784	Response regulator, receiver
HPY14_RS14360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY14_RS14360	COG4191	Histidine kinase
HPY14_RS14370	COG1757	Na H antiporter
HPY14_RS14375	COG2814	Major facilitator Superfamily
HPY14_RS14385	COG3240	lipase activity
HPY14_RS14395	COG0840	transmembrane signaling receptor activity
HPY14_RS14400	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY14_RS14405	COG5380	lipid catabolic process
HPY14_RS14430	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY14_RS14435	COG4605	iron ion homeostasis
HPY14_RS14440	COG4604	ABC transporter, ATP-binding protein
HPY14_RS14445	COG2207	Transcriptional regulator
HPY14_RS14460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY14_RS14480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY14_RS14500	COG0583	DNA-binding transcription factor activity
HPY14_RS14515	COG0745	RESPONSE REGULATOR receiver
HPY14_RS14525	COG3623	hexulose-6-phosphate isomerase
HPY14_RS14530	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY14_RS14535	COG0561	phosphatase activity
HPY14_RS14570	COG0366	Alpha amylase catalytic
HPY14_RS14590	COG0745	RESPONSE REGULATOR receiver
HPY14_RS14595	COG5002	protein histidine kinase activity
HPY14_RS14620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY14_RS14635	COG2814	Major facilitator Superfamily
HPY14_RS14650	COG1686	Belongs to the peptidase S11 family
HPY14_RS14670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY14_RS14670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY14_RS14675	COG0509	glycine decarboxylation via glycine cleavage system
HPY14_RS14680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY14_RS14690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY14_RS14705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY14_RS14710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY14_RS14730	COG0384	phenazine biosynthesis protein PhzF
HPY14_RS14735	COG3040	lipid binding
HPY14_RS14845	COG0456	acetyltransferase
HPY14_RS14920	COG4977	sequence-specific DNA binding
HPY14_RS15135	COG0454	-acetyltransferase
HPY14_RS15145	COG3041	Addiction module toxin RelE StbE family
HPY14_RS15155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY14_RS15185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY14_RS15200	COG4977	sequence-specific DNA binding
HPY14_RS15285	COG0384	phenazine biosynthesis protein PhzF
HPY14_RS15400	COG2176	DNA-directed DNA polymerase activity
HPY14_RS15595	COG0346	lactoylglutathione lyase activity
HPY14_RS15625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY14_RS15680	COG3549	Plasmid maintenance system killer
HPY14_RS15685	COG3093	addiction module antidote protein HigA
HPY14_RS15880	COG5642	Protein of unknown function (DUF2384)
HPY14_RS15890	COG0454	-acetyltransferase
HPY14_RS15905	COG0456	acetyltransferase
HPY14_RS15925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY14_RS15940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY14_RS15945	COG1418	mRNA catabolic process
HPY14_RS15960	COG0384	phenazine biosynthesis protein PhzF
HPY14_RS15995	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY14_RS16005	COG1328	CTP reductase activity
HPY14_RS16010	COG0602	queuosine metabolic process
HPY14_RS16020	COG4067	protein conserved in archaea
HPY14_RS16020	COG0189	ligase activity
HPY14_RS16025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY14_RS16025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY14_RS16025	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY14_RS16030	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY14_RS16035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS16035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS16040	COG1609	Transcriptional regulator
HPY14_RS16045	COG0420	3'-5' exonuclease activity
HPY14_RS16050	COG0419	ATPase involved in DNA repair
HPY14_RS16055	COG2205	protein histidine kinase activity
HPY14_RS16055	COG0784	Response regulator, receiver
HPY14_RS16060	COG0156	8-amino-7-oxononanoate synthase activity
HPY14_RS16070	COG0038	chloride channel
HPY14_RS16075	COG0523	cobalamin synthesis protein
HPY14_RS16085	COG3158	transport of potassium into the cell
HPY14_RS16090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY14_RS16090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY14_RS16090	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY14_RS16090	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY14_RS16095	COG2205	protein histidine kinase activity
HPY14_RS16105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY14_RS16110	COG0586	Pfam SNARE associated Golgi protein
HPY14_RS16120	COG2200	EAL domain
HPY14_RS16130	COG3038	cytochrome b561
HPY14_RS16140	COG2116	formate transmembrane transporter activity
HPY14_RS16145	COG0583	DNA-binding transcription factor activity
HPY14_RS16155	COG3593	DNA synthesis involved in DNA repair
HPY14_RS16160	COG0737	Belongs to the 5'-nucleotidase family
HPY14_RS16175	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY14_RS16225	COG3706	GGDEF domain
HPY14_RS16240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY14_RS16245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY14_RS16255	COG0745	RESPONSE REGULATOR receiver
HPY14_RS16270	COG3140	Belongs to the UPF0181 family
HPY14_RS16275	COG0023	Translation Initiation Factor
HPY14_RS16295	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY14_RS16295	COG1042	CoA-binding domain protein
HPY14_RS16295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY14_RS16300	COG0583	DNA-binding transcription factor activity
HPY14_RS16305	COG4771	TonB-dependent receptor
HPY14_RS16305	COG1629	transport
HPY14_RS16320	COG2050	protein possibly involved in aromatic compounds catabolism
HPY14_RS16340	COG0625	glutathione transferase activity
HPY14_RS16355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY14_RS16360	COG4172	Belongs to the ABC transporter superfamily
HPY14_RS16365	COG4239	(ABC) transporter, permease
HPY14_RS16370	COG4174	ABC transporter (Permease)
HPY14_RS16375	COG4166	transmembrane transport
HPY14_RS16400	COG3104	oligopeptide transport
HPY14_RS16420	COG3842	ATPase activity
HPY14_RS16425	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY14_RS16430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY14_RS16440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY14_RS16445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY14_RS16450	COG1011	Hydrolase
HPY14_RS16460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY14_RS16465	COG1970	mechanosensitive ion channel activity
HPY14_RS16470	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY14_RS16475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY14_RS16475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY14_RS16480	COG0302	gtp cyclohydrolase
HPY14_RS16490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY14_RS16500	COG2897	thiosulfate sulfurtransferase activity
HPY14_RS16505	COG2390	Transcriptional regulator
HPY14_RS16515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY14_RS16545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY14_RS16555	COG0494	nUDIX hydrolase
HPY14_RS16570	COG0583	DNA-binding transcription factor activity
HPY14_RS16575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY14_RS16615	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY14_RS16660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY14_RS16660	COG1263	PTS System
HPY14_RS16675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY14_RS16680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY14_RS16685	COG0840	transmembrane signaling receptor activity
HPY14_RS16690	COG2885	chlorophyll binding
HPY14_RS16695	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY14_RS16700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY14_RS16705	COG0840	transmembrane signaling receptor activity
HPY14_RS16710	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY14_RS16715	COG1760	l-serine dehydratase
HPY14_RS16735	COG1609	Transcriptional regulator
HPY14_RS16740	COG2197	response regulator
HPY14_RS16745	COG3850	Histidine kinase
HPY14_RS16750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY14_RS16760	COG0243	molybdopterin cofactor binding
HPY14_RS16780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY14_RS16785	COG2197	response regulator
HPY14_RS16790	COG3851	Histidine kinase
HPY14_RS16795	COG2271	Major facilitator Superfamily
HPY14_RS16800	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY14_RS16810	COG3842	ATPase activity
HPY14_RS16815	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY14_RS16825	COG0183	Belongs to the thiolase family
HPY14_RS16835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY14_RS16840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY14_RS16855	COG3706	GGDEF domain
HPY14_RS16860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY14_RS16870	COG1979	alcohol dehydrogenase
HPY14_RS16885	COG4191	Histidine kinase
HPY14_RS16895	COG2271	Major facilitator Superfamily
HPY14_RS16900	COG0469	pyruvate kinase activity
HPY14_RS16905	COG0784	Response regulator, receiver
HPY14_RS16905	COG2198	Histidine kinase
HPY14_RS16905	COG2205	protein histidine kinase activity
HPY14_RS16910	COG1879	ABC-type sugar transport system periplasmic component
HPY14_RS16915	COG1803	Methylglyoxal synthase
HPY14_RS16920	COG1335	isochorismatase
HPY14_RS16925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY14_RS16930	COG0210	DNA helicase
HPY14_RS16935	COG1289	transmembrane transporter activity
HPY14_RS16965	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY14_RS16970	COG4149	molybdate abc transporter
HPY14_RS16975	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY14_RS16980	COG1492	cobalamin metabolic process
HPY14_RS17010	COG0784	Response regulator, receiver
HPY14_RS17010	COG5002	protein histidine kinase activity
HPY14_RS17015	COG1879	ABC-type sugar transport system periplasmic component
HPY14_RS17025	COG2827	Endonuclease containing a URI domain
HPY14_RS17040	COG2926	Belongs to the UPF0265 family
HPY14_RS17050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY14_RS17055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY14_RS17060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY14_RS17065	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HPY14_RS17070	COG0247	lactate metabolic process
HPY14_RS17075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY14_RS17080	COG3118	belongs to the thioredoxin family
HPY14_RS17105	COG4160	amino acid transport
HPY14_RS17110	COG4215	(ABC) transporter
HPY14_RS17115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY14_RS17120	COG1126	abc transporter atp-binding protein
HPY14_RS17130	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY14_RS17140	COG0494	nUDIX hydrolase
HPY14_RS17145	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY14_RS17155	COG1309	transcriptional regulator
HPY14_RS17160	COG0513	Belongs to the DEAD box helicase family
HPY14_RS17165	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY14_RS17170	COG0814	amino acid
HPY14_RS17175	COG0840	transmembrane signaling receptor activity
HPY14_RS17180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY14_RS17185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY14_RS17195	COG1984	allophanate hydrolase subunit 2
HPY14_RS17210	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY14_RS17215	COG4181	ATPase activity
HPY14_RS17225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY14_RS17230	COG1716	ATPase activity
HPY14_RS17230	COG5001	Diguanylate cyclase
HPY14_RS17240	COG0484	heat shock protein binding
HPY14_RS17255	COG0546	phosphoglycolate phosphatase activity
HPY14_RS17270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY14_RS17275	COG1368	sulfuric ester hydrolase activity
HPY14_RS17285	COG0513	Belongs to the DEAD box helicase family
HPY14_RS17300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY14_RS17310	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY14_RS17315	COG3397	chitin binding
HPY14_RS17335	COG1166	arginine decarboxylase activity
HPY14_RS17345	COG2239	Acts as a magnesium transporter
HPY14_RS17350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY14_RS17355	COG0459	protein refolding
HPY14_RS17365	COG0527	aspartate kinase activity
HPY14_RS17370	COG0662	Cupin 2, conserved barrel domain protein
HPY14_RS17375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY14_RS17380	COG0456	acetyltransferase
HPY14_RS17385	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY14_RS17390	COG3186	Phenylalanine-4-hydroxylase
HPY14_RS17395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY14_RS17410	COG2264	protein methyltransferase activity
HPY14_RS17435	COG1253	flavin adenine dinucleotide binding
HPY14_RS17440	COG1765	OsmC-like protein
HPY14_RS17470	COG1252	NADH dehydrogenase
HPY14_RS17475	COG0531	amino acid
HPY14_RS17480	COG3706	GGDEF domain
HPY14_RS17490	COG3279	Response regulator of the LytR AlgR family
HPY14_RS17495	COG3275	phosphorelay sensor kinase activity
HPY14_RS17510	COG1136	(ABC) transporter
HPY14_RS17510	COG0577	efflux transmembrane transporter activity
HPY14_RS17515	COG1136	(ABC) transporter
HPY14_RS17525	COG4989	oxidoreductase activity
HPY14_RS17530	COG0366	Alpha amylase catalytic
HPY14_RS17540	COG2067	long-chain fatty acid transport protein
HPY14_RS17545	COG2267	carboxylic ester hydrolase activity
HPY14_RS17555	COG3227	Zinc metalloprotease (Elastase)
HPY14_RS17560	COG3047	cAMP biosynthetic process
HPY14_RS17570	COG1686	Belongs to the peptidase S11 family
HPY14_RS17575	COG0557	exoribonuclease II activity
HPY14_RS17580	COG1278	Cold shock
HPY14_RS17590	COG3048	D-serine ammonia-lyase activity
HPY14_RS17595	COG0583	DNA-binding transcription factor activity
HPY14_RS17615	COG1063	alcohol dehydrogenase
HPY14_RS17625	COG2873	o-acetylhomoserine
HPY14_RS17635	COG0346	lactoylglutathione lyase activity
HPY14_RS17655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY14_RS17660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY14_RS17665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY14_RS17670	COG0363	glucosamine-6-phosphate deaminase activity
HPY14_RS17675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY14_RS17700	COG1929	Belongs to the glycerate kinase type-1 family
HPY14_RS17705	COG2610	gluconate transmembrane transporter activity
HPY14_RS17710	COG3835	regulator
HPY14_RS17720	COG0748	coenzyme F420 binding
HPY14_RS17725	COG3721	Heme iron utilization protein
HPY14_RS17735	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY14_RS17740	COG0811	peptide transport
HPY14_RS17745	COG0848	biopolymer transport protein
HPY14_RS17750	COG4558	Periplasmic binding protein
HPY14_RS17755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY14_RS17760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY14_RS17795	COG0633	Ferredoxin
HPY14_RS17795	COG0633	Ferredoxin
HPY14_RS17795	COG3217	Mosc domain protein beta barrel domain protein
HPY14_RS17795	COG3217	Mosc domain protein beta barrel domain protein
HPY14_RS17800	COG0418	dihydroorotase activity
HPY14_RS17810	COG3152	Membrane
HPY14_RS17820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY14_RS17825	COG2354	Protein conserved in bacteria
HPY14_RS17835	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY14_RS17840	COG1278	Cold shock
HPY14_RS17855	COG4753	response regulator
HPY14_RS17855	COG2207	Transcriptional regulator
HPY14_RS17865	COG3706	GGDEF domain
HPY14_RS17870	COG1349	DNA-binding transcription factor activity
HPY14_RS17885	COG3833	ABC-type maltose transport systems, permease component
HPY14_RS17890	COG1175	transmembrane transport
HPY14_RS17900	COG3842	ATPase activity
HPY14_RS17905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY14_RS17920	COG0393	Putative heavy-metal-binding
HPY14_RS17930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY14_RS17935	COG0784	Response regulator, receiver
HPY14_RS17935	COG0835	chemotaxis
HPY14_RS17940	COG1846	Transcriptional regulator
HPY14_RS17945	COG3706	GGDEF domain
HPY14_RS17980	COG0583	DNA-binding transcription factor activity
HPY14_RS17985	COG5001	Diguanylate cyclase
HPY14_RS17995	COG1741	Belongs to the pirin family
HPY14_RS18000	COG3123	guanosine phosphorylase activity
HPY14_RS18010	COG2211	Major facilitator Superfamily
HPY14_RS18020	COG1067	ATP-dependent peptidase activity
HPY14_RS18030	COG4172	Belongs to the ABC transporter superfamily
HPY14_RS18050	COG0583	DNA-binding transcription factor activity
HPY14_RS18060	COG1620	l-lactate permease
HPY14_RS18075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY14_RS18085	COG0840	transmembrane signaling receptor activity
HPY14_RS18095	COG0513	Belongs to the DEAD box helicase family
HPY14_RS18105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPY14_RS18115	COG1132	(ABC) transporter
HPY14_RS18125	COG1902	pentaerythritol trinitrate reductase activity
HPY14_RS18135	COG1280	lysine exporter protein (LysE YggA)
HPY14_RS18140	COG2207	Transcriptional regulator
HPY14_RS18160	COG1846	Transcriptional regulator
HPY14_RS18165	COG1764	response to oxidative stress
HPY14_RS18170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY14_RS18175	COG0697	spore germination
HPY14_RS18185	COG0700	Nucleoside recognition
HPY14_RS18190	COG3366	ferrous iron transmembrane transporter activity
HPY14_RS18195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY14_RS18200	COG4565	transcriptional regulatory protein
HPY14_RS18210	COG0471	metal ion transport
HPY14_RS18220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY14_RS18225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY14_RS18230	COG2259	Doxx family
HPY14_RS18255	COG0363	glucosamine-6-phosphate deaminase activity
HPY14_RS18275	COG4580	involved in the transport of maltose and maltodextrins
HPY14_RS18290	COG0840	transmembrane signaling receptor activity
HPY14_RS18300	COG0840	transmembrane signaling receptor activity
HPY14_RS18305	COG5001	Diguanylate cyclase
HPY14_RS18315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY14_RS18320	COG1126	abc transporter atp-binding protein
HPY14_RS18330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY14_RS18335	COG4597	amino acid ABC transporter
HPY14_RS18340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY14_RS18345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY14_RS18345	COG2213	PTS system mannitol-specific
HPY14_RS18350	COG0246	Mannitol dehydrogenase
HPY14_RS18355	COG3722	fumarate hydratase activity
HPY14_RS18385	COG0697	spore germination
HPY14_RS18410	COG2910	NAD(P)H-binding
HPY14_RS18425	COG4221	oxidoreductase activity
HPY14_RS18435	COG1901	pseudouridine methyltransferase
HPY14_RS18450	COG0531	amino acid
HPY14_RS18455	COG1982	Orn Lys Arg decarboxylase major
HPY14_RS18485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY14_RS18510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY14_RS18550	COG0745	RESPONSE REGULATOR receiver
HPY14_RS18575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY14_RS18580	COG0840	transmembrane signaling receptor activity
HPY14_RS18585	COG0835	chemotaxis
HPY14_RS18590	COG0835	chemotaxis
HPY14_RS18595	COG0643	Histidine kinase
HPY14_RS18595	COG2198	Histidine kinase
HPY14_RS18615	COG0601	transmembrane transport
HPY14_RS18620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY14_RS18630	COG2194	sulfuric ester hydrolase activity
HPY14_RS18635	COG0642	Histidine kinase
HPY14_RS18640	COG0745	RESPONSE REGULATOR receiver
HPY14_RS18670	COG1444	tRNA N-acetyltransferase activity
HPY14_RS18675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine