locus-tag	class	description
HPY06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY06_RS00010	COG0592	DNA-directed DNA polymerase activity
HPY06_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY06_RS00020	COG0187	DNA topoisomerase II activity
HPY06_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY06_RS00035	COG3977	Valine--pyruvate aminotransferase
HPY06_RS00040	COG0751	glycine-tRNA ligase activity
HPY06_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY06_RS00050	COG2119	membrane
HPY06_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY06_RS00070	COG0604	alcohol dehydrogenase
HPY06_RS00080	COG0129	dihydroxy-acid dehydratase activity
HPY06_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY06_RS00100	COG0606	chelatase, subunit chli
HPY06_RS00105	COG0204	Acyl-transferase
HPY06_RS00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY06_RS00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY06_RS00130	COG3084	Protein conserved in bacteria
HPY06_RS00135	COG4326	sporulation control protein
HPY06_RS00140	COG1272	protein, Hemolysin III
HPY06_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY06_RS00155	COG0569	domain protein
HPY06_RS00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY06_RS00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY06_RS00165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPY06_RS00170	COG0242	peptide deformylase activity
HPY06_RS00175	COG1652	LysM domain
HPY06_RS00180	COG0758	DNA mediated transformation
HPY06_RS00185	COG2922	Belongs to the Smg family
HPY06_RS00190	COG0551	DNA topoisomerase type I activity
HPY06_RS00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY06_RS00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY06_RS00205	COG0009	L-threonylcarbamoyladenylate synthase
HPY06_RS00210	COG0408	coproporphyrinogen oxidase activity
HPY06_RS00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY06_RS00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY06_RS00265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY06_RS00270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY06_RS00280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY06_RS00285	COG2104	thiamine diphosphate biosynthetic process
HPY06_RS00290	COG2022	thiamine diphosphate biosynthetic process
HPY06_RS00295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY06_RS00300	COG0006	proline dipeptidase activity
HPY06_RS00300	COG0006	proline dipeptidase activity
HPY06_RS00320	COG1522	sequence-specific DNA binding
HPY06_RS00325	COG5001	Diguanylate cyclase
HPY06_RS00325	COG5002	protein histidine kinase activity
HPY06_RS00345	COG0589	response to stress
HPY06_RS00350	COG1528	Iron-storage protein
HPY06_RS00360	COG2081	HI0933 family
HPY06_RS00370	COG1322	Protein conserved in bacteria
HPY06_RS00375	COG2226	methyltransferase
HPY06_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY06_RS00395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY06_RS00400	COG0805	protein transport
HPY06_RS00405	COG1858	cytochrome C peroxidase
HPY06_RS00410	COG0534	Mate efflux family protein
HPY06_RS00420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY06_RS00425	COG2937	Belongs to the GPAT DAPAT family
HPY06_RS00430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY06_RS00435	COG3161	chorismate lyase activity
HPY06_RS00440	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY06_RS00445	COG0840	transmembrane signaling receptor activity
HPY06_RS00455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY06_RS00460	COG0084	hydrolase, TatD family'
HPY06_RS00475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY06_RS00475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY06_RS00495	COG3078	GTPase activator activity
HPY06_RS00510	COG3071	HemY protein
HPY06_RS00515	COG2959	enzyme of heme biosynthesis
HPY06_RS00520	COG1587	Uroporphyrinogen-III synthase
HPY06_RS00525	COG0181	hydroxymethylbilane synthase activity
HPY06_RS00535	COG1965	Belongs to the frataxin family
HPY06_RS00545	COG0019	diaminopimelate decarboxylase activity
HPY06_RS00550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY06_RS00560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY06_RS00565	COG1011	Hydrolase
HPY06_RS00570	COG3287	FIST C domain
HPY06_RS00570	COG2200	EAL domain
HPY06_RS00570	COG2199	diguanylate cyclase activity
HPY06_RS00585	COG0561	phosphatase activity
HPY06_RS00590	COG2267	carboxylic ester hydrolase activity
HPY06_RS00595	COG1280	lysine exporter protein (LysE YggA)
HPY06_RS00600	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY06_RS00605	COG0783	Belongs to the Dps family
HPY06_RS00635	COG0742	ribosomal rna small subunit methyltransferase
HPY06_RS00640	COG0552	protein localization to endoplasmic reticulum
HPY06_RS00645	COG2884	Cell division ATP-binding protein ftsE
HPY06_RS00650	COG2177	Part of the ABC transporter FtsEX involved in
HPY06_RS00655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY06_RS00660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_RS00675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY06_RS00680	COG4206	TonB-dependent receptor
HPY06_RS00685	COG1404	Belongs to the peptidase S8 family
HPY06_RS00690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY06_RS00755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY06_RS00760	COG3300	MHYT domain
HPY06_RS00760	COG5001	Diguanylate cyclase
HPY06_RS00770	COG3852	Histidine kinase
HPY06_RS00780	COG0174	glutamine synthetase
HPY06_RS00800	COG1295	ribonuclease BN
HPY06_RS00805	COG1490	D-aminoacyl-tRNA deacylase activity
HPY06_RS00810	COG0456	acetyltransferase
HPY06_RS00820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY06_RS00825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY06_RS00830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY06_RS00835	COG3031	protein transport across the cell outer membrane
HPY06_RS00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY06_RS00850	COG1459	type II secretion system
HPY06_RS00855	COG2165	general secretion pathway protein
HPY06_RS00860	COG2165	general secretion pathway protein
HPY06_RS00865	COG2165	general secretion pathway protein
HPY06_RS00870	COG4795	General secretion pathway protein
HPY06_RS00875	COG3156	type II secretion system protein K
HPY06_RS00880	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY06_RS00885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY06_RS00895	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY06_RS00900	COG0494	nUDIX hydrolase
HPY06_RS00910	COG1040	competence protein
HPY06_RS00920	COG0596	Alpha beta hydrolase
HPY06_RS00930	COG2183	response to ionizing radiation
HPY06_RS00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY06_RS00940	COG2199	diguanylate cyclase activity
HPY06_RS00945	COG0745	RESPONSE REGULATOR receiver
HPY06_RS00955	COG2233	PERMEase
HPY06_RS00960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY06_RS00965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY06_RS00970	COG1758	RNA polymerase activity
HPY06_RS00975	COG0194	GDP metabolic process
HPY06_RS00980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY06_RS00985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY06_RS01005	COG4232	protein-disulfide reductase activity
HPY06_RS01020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY06_RS01025	COG1027	Aspartate ammonia-lyase
HPY06_RS01030	COG3706	GGDEF domain
HPY06_RS01035	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY06_RS01040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY06_RS01050	COG2205	protein histidine kinase activity
HPY06_RS01055	COG0745	RESPONSE REGULATOR receiver
HPY06_RS01065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY06_RS01070	COG0205	6-phosphofructokinase activity
HPY06_RS01075	COG1494	fructose-1,6-bisphosphatase
HPY06_RS01080	COG3074	FtsZ-dependent cytokinesis
HPY06_RS01085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY06_RS01090	COG0460	homoserine dehydrogenase
HPY06_RS01090	COG0527	aspartate kinase activity
HPY06_RS01095	COG0626	cystathionine gamma-synthase activity
HPY06_RS01100	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY06_RS01105	COG0281	malic enzyme
HPY06_RS01110	COG0254	rRNA binding
HPY06_RS01115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY06_RS01120	COG1609	Transcriptional regulator
HPY06_RS01125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY06_RS01130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY06_RS01135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY06_RS01140	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY06_RS01145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY06_RS01150	COG0534	Mate efflux family protein
HPY06_RS01155	COG0149	triose-phosphate isomerase activity
HPY06_RS01180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY06_RS01185	COG0459	protein refolding
HPY06_RS01190	COG3344	reverse transcriptase
HPY06_RS01205	COG1509	lysine 2,3-aminomutase activity
HPY06_RS01210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY06_RS01220	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY06_RS01225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY06_RS01230	COG1053	succinate dehydrogenase
HPY06_RS01235	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY06_RS01240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY06_RS01245	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY06_RS01250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY06_RS01255	COG1045	serine acetyltransferase
HPY06_RS01265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY06_RS01270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY06_RS01275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY06_RS01280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY06_RS01285	COG0137	argininosuccinate synthase activity
HPY06_RS01290	COG0165	Argininosuccinate lyase
HPY06_RS01300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_RS01305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY06_RS01305	COG0678	peroxiredoxin activity
HPY06_RS01315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY06_RS01345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY06_RS01350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY06_RS01360	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY06_RS01365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY06_RS01370	COG0546	phosphoglycolate phosphatase activity
HPY06_RS01375	COG0180	Tryptophanyl-tRNA synthetase
HPY06_RS01390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY06_RS01400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY06_RS01425	COG3954	Phosphoribulokinase
HPY06_RS01435	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY06_RS01445	COG0488	(ABC) transporter
HPY06_RS01450	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY06_RS01465	COG1047	Peptidyl-prolyl cis-trans
HPY06_RS01475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY06_RS01480	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY06_RS01485	COG3083	sulfuric ester hydrolase activity
HPY06_RS01490	COG0557	exoribonuclease II activity
HPY06_RS01495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY06_RS01500	COG0051	transcription antitermination factor activity, RNA binding
HPY06_RS01505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY06_RS01510	COG0088	Forms part of the polypeptide exit tunnel
HPY06_RS01515	COG0089	rRNA binding
HPY06_RS01520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY06_RS01525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY06_RS01530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY06_RS01535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY06_RS01540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY06_RS01545	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY06_RS01550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY06_RS01555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY06_RS01560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY06_RS01565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY06_RS01570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY06_RS01575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY06_RS01580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY06_RS01585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY06_RS01590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY06_RS01595	COG1841	ribosomal large subunit assembly
HPY06_RS01605	COG0201	protein transport
HPY06_RS01610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY06_RS01615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY06_RS01620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY06_RS01625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY06_RS01630	COG0202	RNA polymerase activity
HPY06_RS01635	COG0203	ribosomal protein L17
HPY06_RS01645	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY06_RS01650	COG3266	domain, Protein
HPY06_RS01650	COG3061	Opacity-associated protein A
HPY06_RS01655	COG0697	spore germination
HPY06_RS01660	COG2153	protein acetylation
HPY06_RS01665	COG0513	Belongs to the DEAD box helicase family
HPY06_RS01675	COG0737	Belongs to the 5'-nucleotidase family
HPY06_RS01680	COG1648	precorrin-2 dehydrogenase activity
HPY06_RS01680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY06_RS01685	COG0175	sulfate reduction
HPY06_RS01690	COG2895	sulfate adenylyltransferase (ATP) activity
HPY06_RS01695	COG0529	Catalyzes the synthesis of activated sulfate
HPY06_RS01715	COG1136	(ABC) transporter
HPY06_RS01730	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY06_RS01735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_RS01740	COG0729	surface antigen
HPY06_RS01750	COG2105	PFAM AIG2 family protein
HPY06_RS01755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY06_RS01765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY06_RS01770	COG0163	prenyltransferase activity
HPY06_RS01780	COG1178	ABC-type Fe3 transport system permease component
HPY06_RS01785	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY06_RS01790	COG3028	Belongs to the UPF0307 family
HPY06_RS01795	COG0312	modulator of DNA gyrase
HPY06_RS01800	COG2239	Acts as a magnesium transporter
HPY06_RS01805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_RS01810	COG1660	Displays ATPase and GTPase activities
HPY06_RS01815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_RS01820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY06_RS01830	COG1137	ATPase activity
HPY06_RS01835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY06_RS01850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY06_RS01850	COG0517	IMP dehydrogenase activity
HPY06_RS01860	COG1127	ABC transporter
HPY06_RS01865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY06_RS01870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY06_RS01875	COG2854	intermembrane phospholipid transfer
HPY06_RS01885	COG5007	Belongs to the BolA IbaG family
HPY06_RS01890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY06_RS01900	COG0251	oxidation-reduction process
HPY06_RS01910	COG0540	Belongs to the ATCase OTCase family
HPY06_RS01920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY06_RS01925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPY06_RS01930	COG0564	pseudouridine synthase activity
HPY06_RS01935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY06_RS01940	COG0525	valine-tRNA ligase activity
HPY06_RS01945	COG2927	DNA polymerase III (CHI subunit)
HPY06_RS01950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY06_RS01955	COG0795	lipopolysaccharide-transporting ATPase activity
HPY06_RS01960	COG0795	lipopolysaccharide-transporting ATPase activity
HPY06_RS01975	COG3437	response regulator, receiver
HPY06_RS02015	COG0066	3-isopropylmalate dehydratase activity
HPY06_RS02020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY06_RS02025	COG0473	3-isopropylmalate dehydrogenase activity
HPY06_RS02045	COG0583	DNA-binding transcription factor activity
HPY06_RS02050	COG1022	Amp-dependent synthetase and ligase
HPY06_RS02055	COG0028	Belongs to the TPP enzyme family
HPY06_RS02060	COG0440	acetolactate synthase activity
HPY06_RS02065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY06_RS02070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY06_RS02075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY06_RS02085	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY06_RS02090	COG3079	Belongs to the UPF0149 family
HPY06_RS02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_RS02100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_RS02110	COG0354	folic acid binding
HPY06_RS02115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY06_RS02125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY06_RS02130	COG1595	DNA-templated transcription, initiation
HPY06_RS02145	COG3086	response to oxidative stress
HPY06_RS02150	COG0481	GTPase activity
HPY06_RS02160	COG0571	ribonuclease III activity
HPY06_RS02165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY06_RS02170	COG1381	Involved in DNA repair and RecF pathway recombination
HPY06_RS02175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY06_RS02180	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY06_RS02195	COG5001	Diguanylate cyclase
HPY06_RS02200	COG2205	protein histidine kinase activity
HPY06_RS02200	COG3850	Histidine kinase
HPY06_RS02200	COG4999	Histidine kinase
HPY06_RS02200	COG3437	response regulator, receiver
HPY06_RS02210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY06_RS02215	COG3956	TIGRFAM MazG family protein
HPY06_RS02220	COG0504	CTP synthase activity
HPY06_RS02225	COG0148	phosphopyruvate hydratase activity
HPY06_RS02230	COG0617	tRNA 3'-terminal CCA addition
HPY06_RS02235	COG3409	Peptidoglycan-binding domain 1 protein
HPY06_RS02235	COG3267	Type II secretory pathway component ExeA
HPY06_RS02245	COG4991	sh3 domain protein
HPY06_RS02250	COG0306	phosphate transporter
HPY06_RS02255	COG1392	Phosphate transport regulator
HPY06_RS02260	COG3025	triphosphatase activity
HPY06_RS02265	COG0840	transmembrane signaling receptor activity
HPY06_RS02270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY06_RS02275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPY06_RS02275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPY06_RS02280	COG1538	Outer membrane efflux protein
HPY06_RS02285	COG0494	nUDIX hydrolase
HPY06_RS02290	COG3151	Protein conserved in bacteria
HPY06_RS02300	COG3150	esterase
HPY06_RS02305	COG0187	DNA topoisomerase II activity
HPY06_RS02310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY06_RS02320	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY06_RS02325	COG0237	dephospho-CoA kinase activity
HPY06_RS02335	COG1459	type II secretion system
HPY06_RS02340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY06_RS02350	COG0157	Belongs to the NadC ModD family
HPY06_RS02365	COG0716	FMN binding
HPY06_RS02370	COG4974	Belongs to the 'phage' integrase family
HPY06_RS02375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY06_RS02380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY06_RS02385	COG2186	Transcriptional regulator
HPY06_RS02390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY06_RS02395	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY06_RS02400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_RS02415	COG3116	cell division
HPY06_RS02420	COG0768	penicillin binding
HPY06_RS02425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY06_RS02430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY06_RS02440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY06_RS02445	COG0772	Belongs to the SEDS family
HPY06_RS02450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY06_RS02455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY06_RS02460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY06_RS02465	COG0849	cell division
HPY06_RS02470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY06_RS02475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY06_RS02485	COG0653	protein targeting
HPY06_RS02490	COG0494	nUDIX hydrolase
HPY06_RS02495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY06_RS02505	COG0505	Belongs to the CarA family
HPY06_RS02510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY06_RS02525	COG0730	response to heat
HPY06_RS02530	COG0583	DNA-binding transcription factor activity
HPY06_RS02535	COG2860	membrane
HPY06_RS02540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY06_RS02550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY06_RS02560	COG0493	'glutamate synthase
HPY06_RS02565	COG0070	glutamate synthase
HPY06_RS02565	COG0067	glutamate synthase
HPY06_RS02565	COG0069	glutamate synthase activity
HPY06_RS02575	COG0067	glutamate synthase
HPY06_RS02575	COG0070	glutamate synthase
HPY06_RS02575	COG0069	glutamate synthase activity
HPY06_RS02580	COG1242	4 iron, 4 sulfur cluster binding
HPY06_RS02585	COG3706	GGDEF domain
HPY06_RS02585	COG5001	Diguanylate cyclase
HPY06_RS02585	COG4251	negative regulation of phosphorylation
HPY06_RS02585	COG2203	Gaf domain
HPY06_RS02590	COG5002	protein histidine kinase activity
HPY06_RS02590	COG0784	Response regulator, receiver
HPY06_RS02590	COG2198	Histidine kinase
HPY06_RS02595	COG0745	RESPONSE REGULATOR receiver
HPY06_RS02605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY06_RS02625	COG0083	homoserine kinase activity
HPY06_RS02630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY06_RS02635	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY06_RS02640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY06_RS02645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY06_RS02660	COG1115	amino acid carrier protein
HPY06_RS02665	COG3022	response to hydroperoxide
HPY06_RS02675	COG0084	hydrolase, TatD family'
HPY06_RS02680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY06_RS02690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY06_RS02695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY06_RS02700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY06_RS02705	COG0813	purine-nucleoside phosphorylase activity
HPY06_RS02715	COG0560	Phosphoserine phosphatase
HPY06_RS02725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY06_RS02730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY06_RS02735	COG1022	Amp-dependent synthetase and ligase
HPY06_RS02750	COG3250	beta-galactosidase activity
HPY06_RS02755	COG1609	Transcriptional regulator
HPY06_RS02760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_RS02775	COG0569	domain protein
HPY06_RS02775	COG0189	ligase activity
HPY06_RS02780	COG0456	acetyltransferase
HPY06_RS02790	COG2171	N-acyltransferase activity
HPY06_RS02795	COG3141	response to X-ray
HPY06_RS02810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY06_RS02815	COG1074	ATP-dependent DNA helicase activity
HPY06_RS02820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY06_RS02830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY06_RS02830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY06_RS02840	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY06_RS02845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY06_RS02850	COG2166	iron-sulfur cluster assembly
HPY06_RS02855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY06_RS02860	COG0693	protein deglycase activity
HPY06_RS02865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY06_RS02870	COG3248	Nucleoside-binding outer membrane protein
HPY06_RS02880	COG1595	DNA-templated transcription, initiation
HPY06_RS02890	COG2211	Major facilitator Superfamily
HPY06_RS02905	COG2813	Specifically methylates the guanine in position
HPY06_RS02910	COG0271	Belongs to the BolA IbaG family
HPY06_RS02915	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_RS02920	COG1805	sodium ion transport
HPY06_RS02925	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_RS02930	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_RS02935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY06_RS02940	COG2871	sodium ion transport
HPY06_RS02945	COG1477	protein flavinylation
HPY06_RS02965	COG3706	GGDEF domain
HPY06_RS02970	COG0733	neurotransmitter:sodium symporter activity
HPY06_RS02980	COG0189	ligase activity
HPY06_RS02985	COG4067	protein conserved in archaea
HPY06_RS02985	COG0189	ligase activity
HPY06_RS02990	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY06_RS02995	COG2252	PERMEase
HPY06_RS03000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY06_RS03015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY06_RS03020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY06_RS03025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY06_RS03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY06_RS03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY06_RS03045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY06_RS03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY06_RS03055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY06_RS03060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY06_RS03070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY06_RS03075	COG0024	Methionine aminopeptidase
HPY06_RS03080	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY06_RS03085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY06_RS03090	COG0528	UMP kinase activity
HPY06_RS03095	COG0233	cytoplasmic translational termination
HPY06_RS03100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY06_RS03105	COG0575	Belongs to the CDS family
HPY06_RS03110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY06_RS03115	COG0750	zinc metalloprotease
HPY06_RS03125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY06_RS03130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_RS03135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY06_RS03140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_RS03145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_RS03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY06_RS03155	COG0587	DNA-directed DNA polymerase activity
HPY06_RS03160	COG0825	malonyl-CoA metabolic process
HPY06_RS03170	COG0037	tRNA processing
HPY06_RS03180	COG3479	Phenolic acid decarboxylase
HPY06_RS03185	COG0347	Belongs to the P(II) protein family
HPY06_RS03190	COG3021	interspecies interaction between organisms
HPY06_RS03195	COG0741	lytic transglycosylase activity
HPY06_RS03195	COG1388	LysM domain
HPY06_RS03200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY06_RS03205	COG2226	methyltransferase
HPY06_RS03210	COG0328	RNA-DNA hybrid ribonuclease activity
HPY06_RS03225	COG1960	acyl-CoA dehydrogenase activity
HPY06_RS03230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY06_RS03235	COG0121	glutamine amidotransferase
HPY06_RS03240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY06_RS03245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY06_RS03250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY06_RS03255	COG3706	GGDEF domain
HPY06_RS03260	COG1187	pseudouridine synthase activity
HPY06_RS03265	COG2840	Smr protein MutS2
HPY06_RS03295	COG2608	mercury ion transmembrane transporter activity
HPY06_RS03295	COG2217	Heavy metal translocating P-type atpase
HPY06_RS03300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY06_RS03315	COG4774	siderophore transport
HPY06_RS03315	COG1629	transport
HPY06_RS03320	COG2375	cellular response to nickel ion
HPY06_RS03325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY06_RS03325	COG2226	methyltransferase
HPY06_RS03325	COG3433	isochorismatase activity
HPY06_RS03360	COG0835	chemotaxis
HPY06_RS03360	COG0784	Response regulator, receiver
HPY06_RS03365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY06_RS03370	COG1815	bacterial-type flagellum-dependent cell motility
HPY06_RS03385	COG1749	Flagellar hook protein flgE
HPY06_RS03390	COG4787	bacterial-type flagellum-dependent cell motility
HPY06_RS03400	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY06_RS03405	COG1706	bacterial-type flagellum-dependent cell motility
HPY06_RS03410	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY06_RS03410	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY06_RS03425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_RS03430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_RS03515	COG0012	GTP binding
HPY06_RS03520	COG0193	aminoacyl-tRNA hydrolase activity
HPY06_RS03525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY06_RS03530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY06_RS03535	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY06_RS03540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY06_RS03545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY06_RS03550	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY06_RS03560	COG2912	Transglutaminase-like superfamily
HPY06_RS03565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY06_RS03570	COG0737	Belongs to the 5'-nucleotidase family
HPY06_RS03575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY06_RS03580	COG2233	PERMEase
HPY06_RS03600	COG1393	Belongs to the ArsC family
HPY06_RS03605	COG4783	chaperone-mediated protein folding
HPY06_RS03625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY06_RS03640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY06_RS03655	COG1876	peptidase activity
HPY06_RS03665	COG1393	Belongs to the ArsC family
HPY06_RS03685	COG2837	iron assimilation
HPY06_RS03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_RS03695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_RS03700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY06_RS03705	COG1334	flagellar protein FlaG
HPY06_RS03710	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY06_RS03720	COG1516	flagellar protein fliS
HPY06_RS03730	COG4191	Histidine kinase
HPY06_RS03740	COG1677	Flagellar hook-basal body complex protein FliE
HPY06_RS03750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY06_RS03780	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY06_RS03805	COG1987	bacterial-type flagellum assembly
HPY06_RS03810	COG1684	flagellar biosynthetic protein fliR
HPY06_RS03820	COG2840	Smr protein MutS2
HPY06_RS03825	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY06_RS03830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY06_RS03835	COG2860	membrane
HPY06_RS03840	COG3101	peptidyl-lysine hydroxylation
HPY06_RS03850	COG0431	NADPH-dependent FMN reductase
HPY06_RS03855	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY06_RS03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY06_RS03860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY06_RS03865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY06_RS03870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY06_RS03875	COG0735	belongs to the Fur family
HPY06_RS03885	COG0583	DNA-binding transcription factor activity
HPY06_RS03895	COG1346	cytolysis
HPY06_RS03910	COG0596	Alpha beta hydrolase
HPY06_RS03915	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY06_RS03920	COG0033	Phosphoglucomutase
HPY06_RS03930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY06_RS03935	COG0372	Belongs to the citrate synthase family
HPY06_RS03940	COG2009	succinate dehydrogenase
HPY06_RS03945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY06_RS03950	COG1053	succinate dehydrogenase
HPY06_RS03960	COG0567	Dehydrogenase, E1 component
HPY06_RS03965	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY06_RS03970	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY06_RS03980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY06_RS03985	COG1121	(ABC) transporter
HPY06_RS03990	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY06_RS03995	COG4977	sequence-specific DNA binding
HPY06_RS04000	COG1918	ferrous iron import across plasma membrane
HPY06_RS04020	COG0018	arginyl-trna synthetase
HPY06_RS04030	COG1025	Belongs to the peptidase M16 family
HPY06_RS04035	COG2062	phosphohistidine phosphatase, SixA
HPY06_RS04065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY06_RS04070	COG2198	Histidine kinase
HPY06_RS04070	COG0784	Response regulator, receiver
HPY06_RS04070	COG0643	Histidine kinase
HPY06_RS04075	COG2201	protein-glutamate methylesterase activity
HPY06_RS04080	COG1192	Involved in chromosome partitioning
HPY06_RS04090	COG0835	chemotaxis
HPY06_RS04100	COG4133	protoheme IX ABC transporter activity
HPY06_RS04105	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY06_RS04110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY06_RS04120	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY06_RS04125	COG1138	Cytochrome C-type biogenesis protein
HPY06_RS04130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY06_RS04135	COG4235	cytochrome complex assembly
HPY06_RS04135	COG3088	subunit of a heme lyase
HPY06_RS04145	COG2853	Lipoprotein
HPY06_RS04165	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY06_RS04170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY06_RS04175	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY06_RS04190	COG3083	sulfuric ester hydrolase activity
HPY06_RS04195	COG3082	Protein of unknown function (DUF1414)
HPY06_RS04200	COG3081	Nucleoid-associated protein
HPY06_RS04210	COG1757	Na H antiporter
HPY06_RS04215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY06_RS04220	COG2095	MarC family integral membrane protein
HPY06_RS04225	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_RS04225	COG1454	alcohol dehydrogenase
HPY06_RS04235	COG0659	secondary active sulfate transmembrane transporter activity
HPY06_RS04240	COG1530	ribonuclease E activity
HPY06_RS04245	COG0564	pseudouridine synthase activity
HPY06_RS04250	COG0424	maF-like protein
HPY06_RS04255	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY06_RS04260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY06_RS04265	COG0416	fatty acid biosynthetic process
HPY06_RS04270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY06_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
HPY06_RS04285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY06_RS04290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY06_RS04295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY06_RS04300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY06_RS04305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY06_RS04315	COG0084	hydrolase, TatD family'
HPY06_RS04320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_RS04320	COG1263	PTS System
HPY06_RS04330	COG0733	neurotransmitter:sodium symporter activity
HPY06_RS04345	COG4667	esterase of the alpha-beta hydrolase superfamily
HPY06_RS04355	COG1940	carbohydrate kinase activity
HPY06_RS04360	COG0784	Response regulator, receiver
HPY06_RS04360	COG0835	chemotaxis
HPY06_RS04375	COG2226	methyltransferase
HPY06_RS04385	COG0676	glucose-6-phosphate 1-epimerase activity
HPY06_RS04390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY06_RS04395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_RS04405	COG3139	Protein of unknown function (DUF1315)
HPY06_RS04410	COG0252	asparaginase activity
HPY06_RS04415	COG0616	signal peptide processing
HPY06_RS04420	COG1902	pentaerythritol trinitrate reductase activity
HPY06_RS04420	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY06_RS04425	COG0788	formyltetrahydrofolate deformylase activity
HPY06_RS04435	COG1199	ATP-dependent helicase activity
HPY06_RS04440	COG1214	PFAM Peptidase M22, glycoprotease
HPY06_RS04455	COG0596	Alpha beta hydrolase
HPY06_RS04460	COG0318	PFAM AMP-dependent synthetase and ligase
HPY06_RS04465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY06_RS04470	COG0705	Rhomboid family
HPY06_RS04480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY06_RS04485	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY06_RS04490	COG0436	Aminotransferase
HPY06_RS04495	COG1169	isochorismate synthase
HPY06_RS04500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY06_RS04505	COG0596	Alpha beta hydrolase
HPY06_RS04525	COG3135	benzoate transporter
HPY06_RS04550	COG3015	lipoprotein NlpE involved in copper resistance
HPY06_RS04555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY06_RS04560	COG2894	cell division
HPY06_RS04565	COG0850	regulation of cytokinetic process
HPY06_RS04570	COG3100	YcgL domain-containing protein
HPY06_RS04575	COG2951	lytic endotransglycosylase activity
HPY06_RS04585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY06_RS04590	COG3005	denitrification pathway
HPY06_RS04595	COG0243	molybdopterin cofactor binding
HPY06_RS04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_RS04625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY06_RS04660	COG4589	Belongs to the CDS family
HPY06_RS04670	COG5001	Diguanylate cyclase
HPY06_RS04670	COG3300	MHYT domain
HPY06_RS04680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY06_RS04685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY06_RS04690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY06_RS04695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY06_RS04705	COG4191	Histidine kinase
HPY06_RS04715	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY06_RS04725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY06_RS04730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY06_RS04735	COG0776	regulation of translation
HPY06_RS04740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY06_RS04745	COG1555	photosystem II stabilization
HPY06_RS04750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY06_RS04755	COG0539	negative regulation of cytoplasmic translation
HPY06_RS04760	COG0776	regulation of translation
HPY06_RS04765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY06_RS04770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY06_RS04790	COG0583	DNA-binding transcription factor activity
HPY06_RS04800	COG0686	Belongs to the AlaDH PNT family
HPY06_RS04810	COG1674	ftsk spoiiie
HPY06_RS04815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY06_RS04820	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY06_RS04825	COG2186	Transcriptional regulator
HPY06_RS04840	COG0537	adenosine 5'-monophosphoramidase activity
HPY06_RS04865	COG3150	esterase
HPY06_RS04870	COG1252	NADH dehydrogenase
HPY06_RS04895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY06_RS04905	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY06_RS04910	COG1136	(ABC) transporter
HPY06_RS04915	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY06_RS04925	COG2333	competence protein COMEC
HPY06_RS04925	COG0658	competence protein
HPY06_RS04930	COG1132	(ABC) transporter
HPY06_RS04935	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY06_RS04940	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY06_RS04945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY06_RS04950	COG2719	SpoVR family
HPY06_RS04955	COG2718	Belongs to the UPF0229 family
HPY06_RS04960	COG2766	serine protein kinase
HPY06_RS04965	COG3013	Belongs to the UPF0304 family
HPY06_RS04975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY06_RS04980	COG0840	transmembrane signaling receptor activity
HPY06_RS04990	COG1882	Formate acetyltransferase
HPY06_RS05015	COG4160	amino acid transport
HPY06_RS05020	COG0708	Exodeoxyribonuclease III
HPY06_RS05030	COG3923	Primosomal replication protein n
HPY06_RS05035	COG0730	response to heat
HPY06_RS05040	COG1199	ATP-dependent helicase activity
HPY06_RS05050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY06_RS05055	COG3012	SEC-C Motif Domain Protein
HPY06_RS05060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY06_RS05065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY06_RS05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY06_RS05075	COG0215	cysteine-tRNA ligase activity
HPY06_RS05080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY06_RS05085	COG0632	four-way junction helicase activity
HPY06_RS05095	COG1271	oxidase subunit
HPY06_RS05100	COG1294	oxidase, subunit
HPY06_RS05105	COG4890	Cyd operon protein YbgT
HPY06_RS05110	COG3790	cyd operon protein YbgE
HPY06_RS05115	COG0824	Thioesterase
HPY06_RS05120	COG0811	peptide transport
HPY06_RS05135	COG0823	Involved in the tonB-independent uptake of proteins
HPY06_RS05140	COG2885	chlorophyll binding
HPY06_RS05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY06_RS05160	COG5002	protein histidine kinase activity
HPY06_RS05160	COG0784	Response regulator, receiver
HPY06_RS05170	COG1482	cell wall glycoprotein biosynthetic process
HPY06_RS05175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_RS05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_RS05175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_RS05180	COG2207	Transcriptional regulator
HPY06_RS05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_RS05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_RS05210	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_RS05215	COG3284	Transcriptional regulator
HPY06_RS05220	COG4628	conserved protein (DUF2132)
HPY06_RS05230	COG0415	Belongs to the DNA photolyase family
HPY06_RS05255	COG4409	exo-alpha-(2->6)-sialidase activity
HPY06_RS05260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY06_RS05265	COG1940	carbohydrate kinase activity
HPY06_RS05275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY06_RS05280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY06_RS05285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY06_RS05290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPY06_RS05295	COG1737	Transcriptional regulator
HPY06_RS05300	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY06_RS05305	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPY06_RS05315	COG4932	domain protein
HPY06_RS05315	COG5492	domain, Protein
HPY06_RS05340	COG0596	Alpha beta hydrolase
HPY06_RS05350	COG3064	Membrane
HPY06_RS05455	COG4789	Type iii secretion
HPY06_RS05460	COG4792	protein secretion
HPY06_RS05490	COG3710	Transcriptional regulator
HPY06_RS05500	COG4790	Type iii secretion
HPY06_RS05580	COG0582	viral genome integration into host DNA
HPY06_RS05590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY06_RS05595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_RS05605	COG3008	intermembrane lipid transfer
HPY06_RS05605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY06_RS05610	COG2995	paraquat-inducible protein a
HPY06_RS05615	COG1309	transcriptional regulator
HPY06_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_RS05640	COG1960	acyl-CoA dehydrogenase activity
HPY06_RS05645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY06_RS05650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY06_RS05655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY06_RS05660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY06_RS05675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY06_RS05680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY06_RS05685	COG0297	glycogen (starch) synthase activity
HPY06_RS05705	COG3070	regulator of competence-specific genes
HPY06_RS05710	COG1609	Transcriptional regulator
HPY06_RS05715	COG3381	protein complex oligomerization
HPY06_RS05720	COG0745	RESPONSE REGULATOR receiver
HPY06_RS05725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY06_RS05730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY06_RS05735	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY06_RS05740	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY06_RS05755	COG1280	lysine exporter protein (LysE YggA)
HPY06_RS05760	COG1032	radical SAM domain protein
HPY06_RS05765	COG5001	Diguanylate cyclase
HPY06_RS05770	COG0612	Peptidase, M16
HPY06_RS05785	COG0583	DNA-binding transcription factor activity
HPY06_RS05790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY06_RS05800	COG2350	Protein conserved in bacteria
HPY06_RS05805	COG1607	acyl-coa hydrolase
HPY06_RS05820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY06_RS05825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY06_RS05835	COG2116	formate transmembrane transporter activity
HPY06_RS05840	COG4459	periplasmic nitrate reductase
HPY06_RS05845	COG3005	denitrification pathway
HPY06_RS05850	COG0243	molybdopterin cofactor binding
HPY06_RS05870	COG1227	inorganic diphosphatase activity
HPY06_RS05890	COG4172	Belongs to the ABC transporter superfamily
HPY06_RS05905	COG4168	peptide transport system, permease
HPY06_RS05915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY06_RS05920	COG1842	Phage shock protein A
HPY06_RS05935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_RS05950	COG2818	Glycosylase
HPY06_RS05955	COG0589	response to stress
HPY06_RS05965	COG0626	cystathionine gamma-synthase activity
HPY06_RS05975	COG0733	neurotransmitter:sodium symporter activity
HPY06_RS05980	COG0564	pseudouridine synthase activity
HPY06_RS05985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY06_RS05990	COG4136	ATPase activity
HPY06_RS05995	COG4135	transport system, permease component
HPY06_RS06000	COG4134	Bacterial extracellular solute-binding protein
HPY06_RS06010	COG3313	Fe-S protein
HPY06_RS06020	COG0814	amino acid
HPY06_RS06030	COG2239	Acts as a magnesium transporter
HPY06_RS06035	COG2205	protein histidine kinase activity
HPY06_RS06035	COG0784	Response regulator, receiver
HPY06_RS06050	COG4934	collagen metabolic process
HPY06_RS06085	COG0840	transmembrane signaling receptor activity
HPY06_RS06095	COG2203	Gaf domain
HPY06_RS06095	COG3706	GGDEF domain
HPY06_RS06095	COG4251	negative regulation of phosphorylation
HPY06_RS06095	COG5001	Diguanylate cyclase
HPY06_RS06100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY06_RS06105	COG5002	protein histidine kinase activity
HPY06_RS06120	COG1061	Type III restriction enzyme res subunit
HPY06_RS06125	COG1187	pseudouridine synthase activity
HPY06_RS06130	COG2814	Major facilitator Superfamily
HPY06_RS06140	COG0702	epimerase
HPY06_RS06145	COG0534	Mate efflux family protein
HPY06_RS06150	COG4181	ATPase activity
HPY06_RS06165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY06_RS06175	COG1748	Saccharopine dehydrogenase
HPY06_RS06190	COG1538	Outer membrane efflux protein
HPY06_RS06210	COG0583	DNA-binding transcription factor activity
HPY06_RS06220	COG1451	nucleotide metabolic process
HPY06_RS06235	COG3063	Type IV pilus biogenesis stability protein PilW
HPY06_RS06240	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY06_RS06260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_RS06275	COG3290	protein histidine kinase activity
HPY06_RS06280	COG4565	transcriptional regulatory protein
HPY06_RS06290	COG0835	chemotaxis
HPY06_RS06290	COG0784	Response regulator, receiver
HPY06_RS06340	COG1085	galactose-1-phosphate uridylyltransferase
HPY06_RS06345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY06_RS06350	COG2017	converts alpha-aldose to the beta-anomer
HPY06_RS06365	COG3527	Alpha-acetolactate decarboxylase
HPY06_RS06375	COG3064	Membrane
HPY06_RS06385	COG0753	catalase activity
HPY06_RS06405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY06_RS06455	COG1271	oxidase subunit
HPY06_RS06460	COG1294	oxidase, subunit
HPY06_RS06465	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY06_RS06465	COG1136	(ABC) transporter
HPY06_RS06470	COG0577	efflux transmembrane transporter activity
HPY06_RS06470	COG1136	(ABC) transporter
HPY06_RS06475	COG0577	efflux transmembrane transporter activity
HPY06_RS06530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY06_RS06545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY06_RS06555	COG2723	6-phospho-beta-galactosidase activity
HPY06_RS06560	COG1609	Transcriptional regulator
HPY06_RS06565	COG0251	oxidation-reduction process
HPY06_RS06570	COG2731	YhcH YjgK YiaL family protein
HPY06_RS06575	COG0584	glycerophosphoryl diester phosphodiesterase
HPY06_RS06580	COG1349	DNA-binding transcription factor activity
HPY06_RS06585	COG3842	ATPase activity
HPY06_RS06590	COG0395	ABC-type sugar transport system, permease component
HPY06_RS06595	COG1175	transmembrane transport
HPY06_RS06610	COG0811	peptide transport
HPY06_RS06615	COG0811	peptide transport
HPY06_RS06620	COG0848	biopolymer transport protein
HPY06_RS06625	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY06_RS06635	COG1793	dna ligase
HPY06_RS06645	COG0534	Mate efflux family protein
HPY06_RS06655	COG3001	Fructosamine kinase
HPY06_RS06665	COG0791	NLP P60 protein
HPY06_RS06670	COG0840	transmembrane signaling receptor activity
HPY06_RS06685	COG1940	carbohydrate kinase activity
HPY06_RS06700	COG0746	molybdenum cofactor guanylyltransferase activity
HPY06_RS06705	COG3842	ATPase activity
HPY06_RS06710	COG4662	Binding-protein-dependent transport system inner membrane component
HPY06_RS06720	COG2204	response regulator
HPY06_RS06725	COG3852	Histidine kinase
HPY06_RS06730	COG0488	(ABC) transporter
HPY06_RS06735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY06_RS06765	COG0243	molybdopterin cofactor binding
HPY06_RS06765	COG3383	formate dehydrogenase (NAD+) activity
HPY06_RS06770	COG0437	4 iron, 4 sulfur cluster binding
HPY06_RS06785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY06_RS06790	COG1666	GTP binding
HPY06_RS06795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY06_RS06810	COG2996	Protein conserved in bacteria
HPY06_RS06820	COG3008	intermembrane lipid transfer
HPY06_RS06825	COG2995	paraquat-inducible protein a
HPY06_RS06830	COG1132	(ABC) transporter
HPY06_RS06835	COG1956	GAF domain-containing protein
HPY06_RS06840	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY06_RS06855	COG0308	aminopeptidase N
HPY06_RS06870	COG0167	dihydroorotate dehydrogenase activity
HPY06_RS06880	COG0116	Belongs to the methyltransferase superfamily
HPY06_RS06880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY06_RS06905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY06_RS06910	COG1067	ATP-dependent peptidase activity
HPY06_RS06915	COG3120	sequence-specific DNA binding
HPY06_RS06990	COG1073	alpha beta
HPY06_RS06990	COG3064	Membrane
HPY06_RS06990	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY06_RS06995	COG2994	toxin metabolic process
HPY06_RS07020	COG2205	protein histidine kinase activity
HPY06_RS07020	COG0784	Response regulator, receiver
HPY06_RS07035	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY06_RS07050	COG2010	Cytochrome c
HPY06_RS07060	COG2217	Heavy metal translocating P-type atpase
HPY06_RS07075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY06_RS07080	COG0589	response to stress
HPY06_RS07085	COG0037	tRNA processing
HPY06_RS07105	COG3842	ATPase activity
HPY06_RS07115	COG1177	transmembrane transport
HPY06_RS07125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY06_RS07140	COG1115	amino acid carrier protein
HPY06_RS07145	COG1280	lysine exporter protein (LysE YggA)
HPY06_RS07180	COG3501	Rhs element vgr protein
HPY06_RS07190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY06_RS07210	COG0513	Belongs to the DEAD box helicase family
HPY06_RS07215	COG2076	Multidrug Resistance protein
HPY06_RS07220	COG0477	Major facilitator Superfamily
HPY06_RS07225	COG0583	DNA-binding transcription factor activity
HPY06_RS07235	COG0402	S-adenosylhomocysteine deaminase activity
HPY06_RS07240	COG0095	Lipoate-protein ligase
HPY06_RS07245	COG0443	Heat shock 70 kDa protein
HPY06_RS07255	COG1643	Atp-dependent helicase
HPY06_RS07285	COG0443	Heat shock 70 kDa protein
HPY06_RS07290	COG0443	Heat shock 70 kDa protein
HPY06_RS07295	COG3706	GGDEF domain
HPY06_RS07325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY06_RS07330	COG0602	queuosine metabolic process
HPY06_RS07335	COG0561	phosphatase activity
HPY06_RS07345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_RS07350	COG4597	amino acid ABC transporter
HPY06_RS07355	COG0765	amino acid transport
HPY06_RS07360	COG1126	abc transporter atp-binding protein
HPY06_RS07365	COG0670	Belongs to the BI1 family
HPY06_RS07370	COG2920	part of a sulfur-relay system
HPY06_RS07375	COG1254	Belongs to the acylphosphatase family
HPY06_RS07380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY06_RS07385	COG3706	GGDEF domain
HPY06_RS07400	COG3437	response regulator, receiver
HPY06_RS07405	COG0625	glutathione transferase activity
HPY06_RS07415	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY06_RS07425	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY06_RS07455	COG0372	Belongs to the citrate synthase family
HPY06_RS07460	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY06_RS07500	COG1566	PFAM secretion protein HlyD family protein
HPY06_RS07520	COG1129	ABC transporter
HPY06_RS07545	COG0745	RESPONSE REGULATOR receiver
HPY06_RS07550	COG5002	protein histidine kinase activity
HPY06_RS07555	COG3713	MltA-interacting MipA family protein
HPY06_RS07560	COG2990	Protein conserved in bacteria
HPY06_RS07570	COG4191	Histidine kinase
HPY06_RS07570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_RS07575	COG0471	metal ion transport
HPY06_RS07585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY06_RS07600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_RS07610	COG3768	UPF0283 membrane protein
HPY06_RS07615	COG3106	COG3106 Predicted ATPase
HPY06_RS07630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY06_RS07635	COG0494	nUDIX hydrolase
HPY06_RS07640	COG0814	amino acid
HPY06_RS07645	COG1760	l-serine dehydratase
HPY06_RS07650	COG0720	synthase
HPY06_RS07655	COG0840	transmembrane signaling receptor activity
HPY06_RS07660	COG0017	Asparaginyl-tRNA synthetase
HPY06_RS07665	COG0351	phosphomethylpyrimidine kinase
HPY06_RS07670	COG2770	Histidine kinase
HPY06_RS07670	COG3437	response regulator, receiver
HPY06_RS07675	COG1448	Aminotransferase
HPY06_RS07690	COG0840	transmembrane signaling receptor activity
HPY06_RS07695	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY06_RS07700	COG2943	transferase activity, transferring hexosyl groups
HPY06_RS07705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY06_RS07710	COG1846	Transcriptional regulator
HPY06_RS07735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY06_RS07750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY06_RS07755	COG3108	Peptidase M15
HPY06_RS07785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY06_RS07795	COG2814	Major facilitator Superfamily
HPY06_RS07815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY06_RS07820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY06_RS07825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY06_RS07855	COG0840	transmembrane signaling receptor activity
HPY06_RS07870	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY06_RS07875	COG4139	cobalamin transport
HPY06_RS07880	COG2988	succinylglutamate desuccinylase activity
HPY06_RS07895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY06_RS07900	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY06_RS07905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_RS07915	COG2925	Exonuclease
HPY06_RS07920	COG1380	Effector of murein hydrolase LrgA
HPY06_RS07925	COG1346	cytolysis
HPY06_RS07955	COG0776	regulation of translation
HPY06_RS07960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_RS07960	COG0072	phenylalanine-tRNA ligase activity
HPY06_RS07965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY06_RS08005	COG0322	excinuclease ABC activity
HPY06_RS08010	COG2197	response regulator
HPY06_RS08015	COG0417	DNA replication proofreading
HPY06_RS08020	COG5001	Diguanylate cyclase
HPY06_RS08030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY06_RS08035	COG3099	Belongs to the UPF0263 family
HPY06_RS08050	COG1228	amidohydrolase
HPY06_RS08055	COG0010	Belongs to the arginase family
HPY06_RS08060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY06_RS08065	COG2986	histidine ammonia-lyase
HPY06_RS08085	COG0277	FAD linked oxidase domain protein
HPY06_RS08085	COG0247	lactate metabolic process
HPY06_RS08100	COG2885	chlorophyll binding
HPY06_RS08120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY06_RS08130	COG0281	malic enzyme
HPY06_RS08140	COG2949	membrane
HPY06_RS08145	COG3706	GGDEF domain
HPY06_RS08150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY06_RS08160	COG0492	ferredoxin-NADP+ reductase activity
HPY06_RS08165	COG4988	ABC transporter
HPY06_RS08170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY06_RS08175	COG1187	pseudouridine synthase activity
HPY06_RS08180	COG0009	L-threonylcarbamoyladenylate synthase
HPY06_RS08185	COG0613	PHP domain protein
HPY06_RS08195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY06_RS08200	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY06_RS08205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY06_RS08210	COG0134	indole-3-glycerol-phosphate synthase activity
HPY06_RS08210	COG0135	phosphoribosylanthranilate isomerase activity
HPY06_RS08215	COG0133	tryptophan synthase activity
HPY06_RS08220	COG0159	tryptophan synthase activity
HPY06_RS08230	COG1435	thymidine kinase activity
HPY06_RS08235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY06_RS08240	COG1801	Protein of unknown function DUF72
HPY06_RS08245	COG4106	trans-aconitate 2-methyltransferase activity
HPY06_RS08250	COG0500	methyltransferase
HPY06_RS08255	COG4067	protein conserved in archaea
HPY06_RS08255	COG0189	ligase activity
HPY06_RS08270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY06_RS08280	COG3852	Histidine kinase
HPY06_RS08295	COG3070	regulator of competence-specific genes
HPY06_RS08305	COG2431	L-lysine efflux transmembrane transporter activity
HPY06_RS08315	COG0076	glutamate decarboxylase activity
HPY06_RS08320	COG1737	Transcriptional regulator
HPY06_RS08325	COG1012	belongs to the aldehyde dehydrogenase family
HPY06_RS08325	COG1454	alcohol dehydrogenase
HPY06_RS08330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY06_RS08335	COG3273	potassium ion transport
HPY06_RS08335	COG2985	domain, Protein
HPY06_RS08340	COG0542	response to heat
HPY06_RS08345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY06_RS08350	COG1278	Cold shock
HPY06_RS08360	COG1187	pseudouridine synthase activity
HPY06_RS08365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY06_RS08365	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY06_RS08370	COG0107	imidazoleglycerol-phosphate synthase activity
HPY06_RS08375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY06_RS08380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY06_RS08385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY06_RS08385	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY06_RS08390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY06_RS08395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY06_RS08400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY06_RS08405	COG1757	Na H antiporter
HPY06_RS08410	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY06_RS08415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_RS08420	COG0482	sulfurtransferase activity
HPY06_RS08425	COG2915	High frequency lysogenization protein hflD homolog
HPY06_RS08430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY06_RS08440	COG2268	Band 7 protein
HPY06_RS08450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY06_RS08465	COG0300	oxidoreductase activity
HPY06_RS08475	COG0501	Belongs to the peptidase M48B family
HPY06_RS08485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY06_RS08490	COG2226	methyltransferase
HPY06_RS08495	COG0156	8-amino-7-oxononanoate synthase activity
HPY06_RS08500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY06_RS08505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY06_RS08510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY06_RS08515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY06_RS08520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY06_RS08530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY06_RS08535	COG2199	diguanylate cyclase activity
HPY06_RS08535	COG2203	Gaf domain
HPY06_RS08545	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY06_RS08555	COG4628	conserved protein (DUF2132)
HPY06_RS08560	COG3092	negative regulation of chromosome organization
HPY06_RS08565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY06_RS08570	COG0857	belongs to the CobB CobQ family
HPY06_RS08570	COG0280	phosphate acetyltransferase
HPY06_RS08575	COG0435	Glutathione S-transferase
HPY06_RS08580	COG4608	Belongs to the ABC transporter superfamily
HPY06_RS08585	COG0444	Belongs to the ABC transporter superfamily
HPY06_RS08590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_RS08595	COG0601	transmembrane transport
HPY06_RS08615	COG2204	response regulator
HPY06_RS08620	COG5001	Diguanylate cyclase
HPY06_RS08620	COG3300	MHYT domain
HPY06_RS08625	COG4191	Histidine kinase
HPY06_RS08630	COG5002	protein histidine kinase activity
HPY06_RS08640	COG2201	protein-glutamate methylesterase activity
HPY06_RS08655	COG0009	L-threonylcarbamoyladenylate synthase
HPY06_RS08670	COG1881	PFAM PEBP family protein
HPY06_RS08695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY06_RS08700	COG0640	Transcriptional regulator
HPY06_RS08710	COG3706	GGDEF domain
HPY06_RS08730	COG1946	Acyl-CoA thioesterase
HPY06_RS08735	COG1522	sequence-specific DNA binding
HPY06_RS08745	COG0616	signal peptide processing
HPY06_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
HPY06_RS08755	COG2983	Belongs to the UPF0260 family
HPY06_RS08765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPY06_RS08770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY06_RS08780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY06_RS08785	COG2832	Protein of unknown function (DUF454)
HPY06_RS08790	COG0745	RESPONSE REGULATOR receiver
HPY06_RS08795	COG0583	DNA-binding transcription factor activity
HPY06_RS08800	COG0778	Nitroreductase
HPY06_RS08805	COG1024	Enoyl-CoA hydratase
HPY06_RS08805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY06_RS08810	COG0183	Belongs to the thiolase family
HPY06_RS08825	COG2067	long-chain fatty acid transport protein
HPY06_RS08835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY06_RS08840	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY06_RS08845	COG2982	Protein involved in outer membrane biogenesis
HPY06_RS08850	COG0572	uridine kinase
HPY06_RS08855	COG0489	protein tyrosine kinase activity
HPY06_RS08860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_RS08860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY06_RS08870	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY06_RS08880	COG0517	IMP dehydrogenase activity
HPY06_RS08880	COG0617	tRNA 3'-terminal CCA addition
HPY06_RS08880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY06_RS08885	COG2199	diguanylate cyclase activity
HPY06_RS08890	COG0314	molybdopterin synthase activity
HPY06_RS08895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY06_RS08900	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY06_RS08905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY06_RS08910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY06_RS08915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY06_RS08920	COG2198	Histidine kinase
HPY06_RS08925	COG2204	response regulator
HPY06_RS08930	COG0556	nucleotide-excision repair
HPY06_RS08940	COG4657	Part of a membrane complex involved in electron transport
HPY06_RS08945	COG2878	Part of a membrane complex involved in electron transport
HPY06_RS08950	COG4656	Part of a membrane complex involved in electron transport
HPY06_RS08965	COG4660	Part of a membrane complex involved in electron transport
HPY06_RS08970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY06_RS08975	COG0346	lactoylglutathione lyase activity
HPY06_RS08990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY06_RS08995	COG2056	Na+-H+ antiporter family
HPY06_RS09000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY06_RS09005	COG1286	toxin biosynthetic process
HPY06_RS09010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY06_RS09015	COG0285	dihydrofolate synthase activity
HPY06_RS09020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY06_RS09025	COG0101	tRNA pseudouridine synthase activity
HPY06_RS09040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_RS09040	COG2190	(PTS) system
HPY06_RS09040	COG1263	PTS System
HPY06_RS09045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY06_RS09050	COG1846	Transcriptional regulator
HPY06_RS09050	COG1940	carbohydrate kinase activity
HPY06_RS09055	COG4651	solute:proton antiporter activity
HPY06_RS09055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY06_RS09060	COG0367	asparagine synthase
HPY06_RS09075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY06_RS09080	COG0563	adenylate kinase activity
HPY06_RS09085	COG0326	Molecular chaperone. Has ATPase activity
HPY06_RS09090	COG3710	Transcriptional regulator
HPY06_RS09105	COG0622	Phosphoesterase
HPY06_RS09110	COG1090	epimerase
HPY06_RS09115	COG0300	oxidoreductase activity
HPY06_RS09120	COG3118	belongs to the thioredoxin family
HPY06_RS09125	COG0330	HflC and HflK could
HPY06_RS09130	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY06_RS09135	COG0789	Transcriptional regulator
HPY06_RS09150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY06_RS09155	COG3115	cell septum assembly
HPY06_RS09160	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY06_RS09165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY06_RS09170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_RS09180	COG2190	(PTS) system
HPY06_RS09185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY06_RS09190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY06_RS09195	COG1702	phosphate starvation-inducible protein PhoH
HPY06_RS09200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY06_RS09205	COG4535	Mg2 and Co2 transporter CorC
HPY06_RS09210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY06_RS09215	COG2888	peptidyl-tyrosine sulfation
HPY06_RS09220	COG0495	leucyl-tRNA aminoacylation
HPY06_RS09225	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY06_RS09230	COG1466	dna polymerase III delta subunit
HPY06_RS09235	COG0799	negative regulation of ribosome biogenesis
HPY06_RS09240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY06_RS09245	COG0768	penicillin binding
HPY06_RS09250	COG0772	Belongs to the SEDS family
HPY06_RS09255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY06_RS09260	COG1686	Belongs to the peptidase S11 family
HPY06_RS09265	COG2921	Belongs to the UPF0250 family
HPY06_RS09270	COG0321	lipoyl(octanoyl) transferase activity
HPY06_RS09275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY06_RS09285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY06_RS09310	COG1596	polysaccharide export
HPY06_RS09320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY06_RS09350	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY06_RS09360	COG0438	transferase activity, transferring glycosyl groups
HPY06_RS09370	COG1045	serine acetyltransferase
HPY06_RS09390	COG0110	maltose O-acetyltransferase activity
HPY06_RS09395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY06_RS09400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY06_RS09405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY06_RS09410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY06_RS09440	COG0366	Alpha amylase catalytic
HPY06_RS09445	COG1263	PTS System
HPY06_RS09445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_RS09450	COG1609	Transcriptional regulator
HPY06_RS09455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY06_RS09460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY06_RS09465	COG2011	ABC-type metal ion transport system permease component
HPY06_RS09470	COG1464	Belongs to the NlpA lipoprotein family
HPY06_RS09475	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY06_RS09485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY06_RS09485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY06_RS09495	COG3706	GGDEF domain
HPY06_RS09500	COG1611	Belongs to the LOG family
HPY06_RS09505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY06_RS09510	COG2363	Small membrane protein
HPY06_RS09515	COG0583	DNA-binding transcription factor activity
HPY06_RS09520	COG0301	tRNA thio-modification
HPY06_RS09520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY06_RS09530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY06_RS09535	COG1722	exodeoxyribonuclease VII activity
HPY06_RS09540	COG0142	geranyltranstransferase activity
HPY06_RS09545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY06_RS09550	COG0564	pseudouridine synthase activity
HPY06_RS09555	COG3098	single-species biofilm formation
HPY06_RS09570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_RS09580	COG1671	Belongs to the UPF0178 family
HPY06_RS09585	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY06_RS09590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY06_RS09595	COG0254	rRNA binding
HPY06_RS09600	COG1720	tRNA m6t6A37 methyltransferase activity
HPY06_RS09605	COG0442	prolyl-tRNA aminoacylation
HPY06_RS09625	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY06_RS09625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY06_RS09635	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY06_RS09645	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY06_RS09675	COG0484	heat shock protein binding
HPY06_RS09680	COG0443	Heat shock 70 kDa protein
HPY06_RS09685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY06_RS09690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY06_RS09695	COG0497	DNA recombination
HPY06_RS09700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_RS09705	COG2914	Belongs to the UPF0125 (RnfH) family
HPY06_RS09710	COG2867	negative regulation of translational initiation
HPY06_RS09715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY06_RS09745	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPY06_RS09765	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY06_RS09770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY06_RS09775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY06_RS09795	COG3051	citrate lyase alpha subunit
HPY06_RS09800	COG2301	Belongs to the HpcH HpaI aldolase family
HPY06_RS09810	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY06_RS09820	COG3630	sodium ion export across plasma membrane
HPY06_RS09825	COG0511	ligase activity, forming carbon-carbon bonds
HPY06_RS09825	COG5016	pyruvate
HPY06_RS09830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY06_RS09840	COG4565	transcriptional regulatory protein
HPY06_RS09865	COG1115	amino acid carrier protein
HPY06_RS09870	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY06_RS09875	COG0583	DNA-binding transcription factor activity
HPY06_RS09885	COG1120	ATPase activity
HPY06_RS09890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_RS09895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_RS09900	COG4592	Periplasmic binding protein
HPY06_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
HPY06_RS09915	COG1169	isochorismate synthase
HPY06_RS09920	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY06_RS09925	COG1535	isochorismatase
HPY06_RS09925	COG3433	isochorismatase activity
HPY06_RS09930	COG1584	GPR1 FUN34 yaaH family protein
HPY06_RS09940	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY06_RS09950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY06_RS09950	COG0519	Catalyzes the synthesis of GMP from XMP
HPY06_RS09955	COG0517	IMP dehydrogenase activity
HPY06_RS09955	COG0516	GMP reductase activity
HPY06_RS09960	COG1570	exodeoxyribonuclease VII activity
HPY06_RS09975	COG1160	GTP binding
HPY06_RS09980	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_RS09985	COG2976	Protein conserved in bacteria
HPY06_RS09990	COG0124	histidyl-tRNA synthetase
HPY06_RS09995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY06_RS10000	COG1426	Protein conserved in bacteria
HPY06_RS10010	COG0105	UTP biosynthetic process
HPY06_RS10015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY06_RS10020	COG2975	iron-sulfur cluster assembly
HPY06_RS10025	COG0633	Ferredoxin
HPY06_RS10045	COG0822	iron-sulfur transferase activity
HPY06_RS10050	COG1104	cysteine desulfurase activity
HPY06_RS10055	COG1959	2 iron, 2 sulfur cluster binding
HPY06_RS10065	COG0483	inositol monophosphate 1-phosphatase activity
HPY06_RS10070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_RS10075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_RS10080	COG1862	Preprotein translocase
HPY06_RS10090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY06_RS10095	COG0517	IMP dehydrogenase activity
HPY06_RS10105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY06_RS10110	COG0583	DNA-binding transcription factor activity
HPY06_RS10115	COG0450	alkyl hydroperoxide reductase
HPY06_RS10120	COG3142	Participates in the control of copper homeostasis
HPY06_RS10135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY06_RS10140	COG0581	inorganic phosphate transmembrane transporter activity
HPY06_RS10150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY06_RS10155	COG0248	Ppx GppA phosphatase
HPY06_RS10165	COG5002	protein histidine kinase activity
HPY06_RS10170	COG0745	RESPONSE REGULATOR receiver
HPY06_RS10185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY06_RS10230	COG0542	response to heat
HPY06_RS10240	COG0564	pseudouridine synthase activity
HPY06_RS10245	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_RS10250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY06_RS10255	COG0077	Prephenate dehydratase
HPY06_RS10255	COG1605	Chorismate mutase
HPY06_RS10260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY06_RS10265	COG5001	Diguanylate cyclase
HPY06_RS10275	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY06_RS10285	COG0488	(ABC) transporter
HPY06_RS10295	COG1605	Chorismate mutase
HPY06_RS10295	COG0287	Prephenate dehydrogenase
HPY06_RS10300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY06_RS10305	COG3275	phosphorelay sensor kinase activity
HPY06_RS10310	COG3279	Response regulator of the LytR AlgR family
HPY06_RS10320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY06_RS10325	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY06_RS10340	COG1966	Carbon starvation protein
HPY06_RS10345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY06_RS10350	COG1047	Peptidyl-prolyl cis-trans
HPY06_RS10355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY06_RS10365	COG0196	riboflavin kinase activity
HPY06_RS10370	COG0728	peptidoglycan biosynthetic process
HPY06_RS10375	COG0268	Binds directly to 16S ribosomal RNA
HPY06_RS10380	COG0640	Transcriptional regulator
HPY06_RS10385	COG0583	DNA-binding transcription factor activity
HPY06_RS10390	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY06_RS10395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPY06_RS10400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY06_RS10405	COG0730	response to heat
HPY06_RS10410	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY06_RS10415	COG0494	nUDIX hydrolase
HPY06_RS10420	COG3066	DNA modification
HPY06_RS10425	COG0667	Aldo Keto reductase
HPY06_RS10435	COG2204	response regulator
HPY06_RS10440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY06_RS10460	COG0513	Belongs to the DEAD box helicase family
HPY06_RS10485	COG3153	acetyltransferase
HPY06_RS10490	COG3154	lipid carrier protein
HPY06_RS10500	COG0826	peptidase U32
HPY06_RS10505	COG0826	peptidase U32
HPY06_RS10535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY06_RS10545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY06_RS10550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY06_RS10555	COG0195	Participates in both transcription termination and antitermination
HPY06_RS10560	COG0779	Required for maturation of 30S ribosomal subunits
HPY06_RS10575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY06_RS10585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY06_RS10590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY06_RS10595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY06_RS10600	COG1534	Rna-binding protein
HPY06_RS10605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY06_RS10610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY06_RS10615	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY06_RS10620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY06_RS10625	COG0739	heme binding
HPY06_RS10640	COG0316	Belongs to the HesB IscA family
HPY06_RS10645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY06_RS10650	COG0628	permease
HPY06_RS10655	COG2813	Specifically methylates the guanine in position
HPY06_RS10660	COG2205	protein histidine kinase activity
HPY06_RS10660	COG0784	Response regulator, receiver
HPY06_RS10665	COG0747	negative chemotaxis
HPY06_RS10675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_RS10680	COG0444	Belongs to the ABC transporter superfamily
HPY06_RS10685	COG4608	Belongs to the ABC transporter superfamily
HPY06_RS10695	COG2971	BadF BadG BcrA BcrD
HPY06_RS10715	COG3842	ATPase activity
HPY06_RS10725	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY06_RS10730	COG0004	ammonium transporteR
HPY06_RS10735	COG0347	Belongs to the P(II) protein family
HPY06_RS10740	COG3112	Uncharacterised protein family (UPF0231)
HPY06_RS10745	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY06_RS10750	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY06_RS10755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY06_RS10760	COG1643	Atp-dependent helicase
HPY06_RS10770	COG1489	DNA binding
HPY06_RS10780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY06_RS10790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY06_RS10795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY06_RS10800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY06_RS10805	COG0842	Transport permease protein
HPY06_RS10810	COG1131	(ABC) transporter
HPY06_RS10815	COG0659	secondary active sulfate transmembrane transporter activity
HPY06_RS10820	COG0288	reversible hydration of carbon dioxide
HPY06_RS10835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY06_RS10840	COG3107	peptidoglycan biosynthetic process
HPY06_RS10845	COG0792	nuclease activity
HPY06_RS10850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY06_RS10855	COG2823	Periplasmic or secreted lipoprotein
HPY06_RS10860	COG2969	positive regulation of protein catabolic process
HPY06_RS10865	COG0625	glutathione transferase activity
HPY06_RS10870	COG2857	Cytochrome c1
HPY06_RS10875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY06_RS10880	COG0723	plastoquinol--plastocyanin reductase activity
HPY06_RS10885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY06_RS10890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY06_RS10895	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY06_RS10905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY06_RS10910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY06_RS10915	COG0335	large ribosomal subunit rRNA binding
HPY06_RS10920	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY06_RS10925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY06_RS10930	COG0228	four-way junction DNA binding
HPY06_RS10935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY06_RS10940	COG4137	Cytochrome C assembly protein
HPY06_RS10945	COG4536	flavin adenine dinucleotide binding
HPY06_RS10950	COG1854	S-ribosylhomocysteine lyase activity
HPY06_RS10955	COG2918	glutathione biosynthetic process
HPY06_RS10960	COG0612	Peptidase, M16
HPY06_RS10965	COG1238	metal cluster binding
HPY06_RS10975	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY06_RS10980	COG0511	ligase activity, forming carbon-carbon bonds
HPY06_RS10980	COG5016	pyruvate
HPY06_RS10985	COG3630	sodium ion export across plasma membrane
HPY06_RS11030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY06_RS11035	COG0527	aspartate kinase activity
HPY06_RS11040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY06_RS11045	COG2137	regulation of response to DNA damage stimulus
HPY06_RS11050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY06_RS11060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY06_RS11065	COG4208	sulfate ABC transporter
HPY06_RS11085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY06_RS11090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY06_RS11100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY06_RS11105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY06_RS11110	COG0585	pseudouridine synthase activity
HPY06_RS11115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY06_RS11120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY06_RS11125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY06_RS11130	COG1968	undecaprenyl-diphosphatase activity
HPY06_RS11135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY06_RS11140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY06_RS11145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY06_RS11155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY06_RS11160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY06_RS11165	COG1610	YqeY-like protein
HPY06_RS11190	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY06_RS11195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY06_RS11200	COG1349	DNA-binding transcription factor activity
HPY06_RS11220	COG1279	arginine transmembrane transporter activity
HPY06_RS11225	COG0668	transmembrane transport
HPY06_RS11230	COG0191	fructose-bisphosphate aldolase activity
HPY06_RS11235	COG0126	phosphoglycerate kinase activity
HPY06_RS11240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY06_RS11245	COG4771	TonB-dependent receptor
HPY06_RS11250	COG0583	DNA-binding transcription factor activity
HPY06_RS11255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY06_RS11260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY06_RS11265	COG3091	SprT-like family
HPY06_RS11270	COG2356	endonuclease I
HPY06_RS11275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPY06_RS11280	COG0189	ligase activity
HPY06_RS11285	COG1678	Uncharacterized ACR, COG1678
HPY06_RS11290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY06_RS11295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY06_RS11315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY06_RS11320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY06_RS11325	COG0762	integral membrane protein
HPY06_RS11330	COG1872	DUF167
HPY06_RS11340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY06_RS11345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY06_RS11350	COG2066	Belongs to the glutaminase family
HPY06_RS11355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY06_RS11360	COG1194	a g-specific adenine glycosylase
HPY06_RS11365	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY06_RS11370	COG0741	lytic transglycosylase activity
HPY06_RS11425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY06_RS11430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY06_RS11435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY06_RS11440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY06_RS11445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY06_RS11450	COG2967	ApaG domain
HPY06_RS11455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY06_RS11465	COG3610	response to peptide
HPY06_RS11470	COG2966	Psort location CytoplasmicMembrane, score
HPY06_RS11475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY06_RS11480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY06_RS11485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY06_RS11490	COG0142	geranyltranstransferase activity
HPY06_RS11495	COG0531	amino acid
HPY06_RS11500	COG0039	L-malate dehydrogenase activity
HPY06_RS11505	COG1438	arginine binding
HPY06_RS11510	COG2358	TRAP transporter, solute receptor (TAXI family
HPY06_RS11520	COG0589	response to stress
HPY06_RS11540	COG2235	arginine
HPY06_RS11545	COG0312	modulator of DNA gyrase
HPY06_RS11550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY06_RS11555	COG3164	Protein of unknown function
HPY06_RS11560	COG1530	ribonuclease E activity
HPY06_RS11565	COG0424	maF-like protein
HPY06_RS11570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY06_RS11575	COG1792	Involved in formation and maintenance of cell shape
HPY06_RS11580	COG1077	Cell shape determining protein MreB Mrl
HPY06_RS11625	COG1459	type II secretion system
HPY06_RS11630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY06_RS11640	COG3409	Peptidoglycan-binding domain 1 protein
HPY06_RS11640	COG3267	Type II secretory pathway component ExeA
HPY06_RS11665	COG2200	EAL domain
HPY06_RS11665	COG2199	diguanylate cyclase activity
HPY06_RS11670	COG0629	single-stranded DNA binding
HPY06_RS11685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY06_RS11695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY06_RS11700	COG0527	aspartate kinase activity
HPY06_RS11705	COG0646	methionine synthase
HPY06_RS11705	COG1410	methionine synthase
HPY06_RS11780	COG0175	sulfate reduction
HPY06_RS11785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPY06_RS11790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY06_RS11815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY06_RS11820	COG0735	belongs to the Fur family
HPY06_RS11840	COG0432	Pfam Uncharacterised protein family UPF0047
HPY06_RS11845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY06_RS11860	COG0359	binds to the 23S rRNA
HPY06_RS11865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY06_RS11870	COG2965	DNA replication, synthesis of RNA primer
HPY06_RS11875	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY06_RS11885	COG2906	2 iron, 2 sulfur cluster binding
HPY06_RS11890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY06_RS11895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY06_RS11900	COG0049	tRNA binding
HPY06_RS11915	COG2923	Belongs to the DsrF TusC family
HPY06_RS11920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY06_RS11925	COG2964	Protein conserved in bacteria
HPY06_RS11930	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY06_RS11940	COG2900	Belongs to the SlyX family
HPY06_RS11945	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY06_RS11950	COG0330	HflC and HflK could
HPY06_RS11955	COG0330	HflC and HflK could
HPY06_RS11960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY06_RS11965	COG1923	regulation of RNA biosynthetic process
HPY06_RS11970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY06_RS11975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY06_RS11985	COG0802	atpase or kinase
HPY06_RS11990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY06_RS12040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY06_RS12045	COG1162	GTPase activity
HPY06_RS12050	COG0688	phosphatidylethanolamine metabolic process
HPY06_RS12055	COG0471	metal ion transport
HPY06_RS12065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY06_RS12070	COG4942	peptidase
HPY06_RS12085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY06_RS12090	COG2816	NAD+ diphosphatase activity
HPY06_RS12095	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY06_RS12100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY06_RS12105	COG0085	RNA polymerase activity
HPY06_RS12110	COG0222	ribosome binding
HPY06_RS12115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY06_RS12125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY06_RS12130	COG0250	Participates in transcription elongation, termination and antitermination
HPY06_RS12135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY06_RS12140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY06_RS12165	COG1072	(Pantothenic acid kinase))
HPY06_RS12175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY06_RS12185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY06_RS12230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY06_RS12245	COG3118	belongs to the thioredoxin family
HPY06_RS12250	COG0513	Belongs to the DEAD box helicase family
HPY06_RS12255	COG0248	Ppx GppA phosphatase
HPY06_RS12260	COG2205	protein histidine kinase activity
HPY06_RS12260	COG0784	Response regulator, receiver
HPY06_RS12265	COG2814	Major facilitator Superfamily
HPY06_RS12280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY06_RS12285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY06_RS12290	COG0511	ligase activity, forming carbon-carbon bonds
HPY06_RS12295	COG0439	Biotin carboxylase
HPY06_RS12300	COG2264	protein methyltransferase activity
HPY06_RS12305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY06_RS12310	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY06_RS12315	COG1609	Transcriptional regulator
HPY06_RS12325	COG0387	Pfam Sodium calcium exchanger
HPY06_RS12330	COG0129	dihydroxy-acid dehydratase activity
HPY06_RS12335	COG3265	gluconokinase activity
HPY06_RS12345	COG0800	Aldolase
HPY06_RS12365	COG0840	transmembrane signaling receptor activity
HPY06_RS12370	COG1982	Orn Lys Arg decarboxylase major
HPY06_RS12375	COG0531	amino acid
HPY06_RS12380	COG3710	Transcriptional regulator
HPY06_RS12385	COG0789	Transcriptional regulator
HPY06_RS12400	COG0151	Belongs to the GarS family
HPY06_RS12410	COG0776	regulation of translation
HPY06_RS12415	COG1253	flavin adenine dinucleotide binding
HPY06_RS12450	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY06_RS12455	COG3068	Protein conserved in bacteria
HPY06_RS12465	COG1573	uracil-dna glycosylase
HPY06_RS12470	COG0668	transmembrane transport
HPY06_RS12475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY06_RS12485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY06_RS12510	COG1086	Polysaccharide biosynthesis protein
HPY06_RS12520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY06_RS12525	COG0482	sulfurtransferase activity
HPY06_RS12580	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY06_RS12595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY06_RS12620	COG0859	PFAM glycosyl transferase family 9
HPY06_RS12630	COG1519	Transferase
HPY06_RS12655	COG3642	lipopolysaccharide core region biosynthetic process
HPY06_RS12660	COG0859	PFAM glycosyl transferase family 9
HPY06_RS12665	COG0463	Glycosyl transferase, family 2
HPY06_RS12670	COG0859	PFAM glycosyl transferase family 9
HPY06_RS12675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY06_RS12680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY06_RS12690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY06_RS12695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY06_RS12700	COG2003	Belongs to the UPF0758 family
HPY06_RS12710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY06_RS12720	COG1309	transcriptional regulator
HPY06_RS12725	COG1560	Kdo2-lipid A biosynthetic process
HPY06_RS12730	COG1560	Kdo2-lipid A biosynthetic process
HPY06_RS12735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY06_RS12740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY06_RS12745	COG1561	YicC-like family, N-terminal region
HPY06_RS12750	COG2862	Uncharacterized protein family, UPF0114
HPY06_RS12755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY06_RS12760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_RS12760	COG1263	PTS System
HPY06_RS12765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY06_RS12785	COG1120	ATPase activity
HPY06_RS12790	COG4774	siderophore transport
HPY06_RS12795	COG1132	(ABC) transporter
HPY06_RS12810	COG0514	ATP-dependent DNA helicase (RecQ)
HPY06_RS12815	COG2962	Rard protein
HPY06_RS12820	COG0405	Gamma-glutamyltransferase
HPY06_RS12830	COG1280	lysine exporter protein (LysE YggA)
HPY06_RS12840	COG0210	DNA helicase
HPY06_RS12850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY06_RS12855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY06_RS12865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_RS12875	COG0747	negative chemotaxis
HPY06_RS12925	COG1309	transcriptional regulator
HPY06_RS12930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY06_RS12935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY06_RS12940	COG2960	long-chain fatty acid transporting porin activity
HPY06_RS12945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY06_RS12950	COG0583	DNA-binding transcription factor activity
HPY06_RS13020	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY06_RS13025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY06_RS13030	COG1739	Uncharacterized protein family UPF0029
HPY06_RS13035	COG1024	Enoyl-CoA hydratase
HPY06_RS13035	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY06_RS13040	COG0183	Belongs to the thiolase family
HPY06_RS13045	COG0583	DNA-binding transcription factor activity
HPY06_RS13050	COG2814	Major facilitator Superfamily
HPY06_RS13060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY06_RS13065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY06_RS13070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY06_RS13075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY06_RS13080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY06_RS13085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY06_RS13095	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY06_RS13100	COG3312	ion transport
HPY06_RS13105	COG1475	DNA binding
HPY06_RS13110	COG1192	Involved in chromosome partitioning
HPY06_RS13115	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY06_RS13120	COG0445	tRNA wobble uridine modification
HPY06_RS13125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY06_RS13130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY06_RS13135	COG0706	membrane insertase activity
HPY06_RS13145	COG0594	ribonuclease P activity
HPY06_RS13150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY06_RS13155	COG1126	abc transporter atp-binding protein
HPY06_RS13200	COG0217	transcriptional regulatory protein
HPY06_RS13205	COG2084	Dehydrogenase
HPY06_RS13220	COG2909	trisaccharide binding
HPY06_RS13225	COG0058	SHG alpha-glucan phosphorylase activity
HPY06_RS13230	COG1640	4-alpha-glucanotransferase
HPY06_RS13235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY06_RS13245	COG3501	Rhs element vgr protein
HPY06_RS13280	COG0471	metal ion transport
HPY06_RS13285	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY06_RS13315	COG0671	phosphoesterase, PA-phosphatase related
HPY06_RS13325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY06_RS13335	COG1999	signal sequence binding
HPY06_RS13350	COG0786	glutamate:sodium symporter activity
HPY06_RS13370	COG1566	PFAM secretion protein HlyD family protein
HPY06_RS13380	COG3706	GGDEF domain
HPY06_RS13395	COG0813	purine-nucleoside phosphorylase activity
HPY06_RS13400	COG3272	Protein of unknown function (DUF1722)
HPY06_RS13410	COG0415	Belongs to the DNA photolyase family
HPY06_RS13415	COG1376	ErfK ybiS ycfS ynhG family protein
HPY06_RS13415	COG1388	LysM domain
HPY06_RS13425	COG0513	Belongs to the DEAD box helicase family
HPY06_RS13430	COG1770	oligopeptidase
HPY06_RS13455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY06_RS13460	COG0573	inorganic phosphate transmembrane transporter activity
HPY06_RS13465	COG0581	inorganic phosphate transmembrane transporter activity
HPY06_RS13470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY06_RS13490	COG0659	secondary active sulfate transmembrane transporter activity
HPY06_RS13500	COG0739	heme binding
HPY06_RS13505	COG5001	Diguanylate cyclase
HPY06_RS13505	COG3300	MHYT domain
HPY06_RS13510	COG0583	DNA-binding transcription factor activity
HPY06_RS13515	COG2814	Major facilitator Superfamily
HPY06_RS13535	COG1301	dicarboxylic acid transport
HPY06_RS13550	COG1342	Belongs to the UPF0251 family
HPY06_RS13585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY06_RS13590	COG0673	inositol 2-dehydrogenase activity
HPY06_RS13600	COG2771	luxR family
HPY06_RS13600	COG2200	EAL domain
HPY06_RS13605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY06_RS13615	COG0564	pseudouridine synthase activity
HPY06_RS13705	COG3501	Rhs element vgr protein
HPY06_RS13735	COG1869	D-ribose catabolic process
HPY06_RS13740	COG1129	ABC transporter
HPY06_RS13745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY06_RS13750	COG1879	ABC-type sugar transport system periplasmic component
HPY06_RS13755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_RS13760	COG1609	Transcriptional regulator
HPY06_RS13770	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY06_RS13780	COG0584	glycerophosphoryl diester phosphodiesterase
HPY06_RS13785	COG2271	Major facilitator Superfamily
HPY06_RS13820	COG0579	oxidoreductase
HPY06_RS13830	COG0242	peptide deformylase activity
HPY06_RS13835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY06_RS13835	COG1017	nitric oxide dioxygenase activity
HPY06_RS13840	COG1320	monovalent cation:proton antiporter activity
HPY06_RS13845	COG2212	antiporter activity
HPY06_RS13865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY06_RS13865	COG2111	Na H antiporter
HPY06_RS13875	COG0589	response to stress
HPY06_RS13880	COG0814	amino acid
HPY06_RS13895	COG3530	Putative quorum-sensing-regulated virulence factor
HPY06_RS13905	COG5002	protein histidine kinase activity
HPY06_RS13905	COG5001	Diguanylate cyclase
HPY06_RS13910	COG1278	Cold shock
HPY06_RS13925	COG2304	oxidoreductase activity
HPY06_RS13945	COG0714	Associated with various cellular activities
HPY06_RS13950	COG0840	transmembrane signaling receptor activity
HPY06_RS13965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY06_RS13970	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY06_RS13980	COG3604	Transcriptional regulator
HPY06_RS13985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY06_RS13985	COG1017	nitric oxide dioxygenase activity
HPY06_RS13990	COG1278	Cold shock
HPY06_RS13995	COG3036	rescue of stalled ribosome
HPY06_RS14020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY06_RS14020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY06_RS14025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY06_RS14035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY06_RS14045	COG0516	GMP reductase activity
HPY06_RS14075	COG0513	Belongs to the DEAD box helicase family
HPY06_RS14080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY06_RS14085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY06_RS14090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPY06_RS14095	COG0784	Response regulator, receiver
HPY06_RS14095	COG3437	response regulator, receiver
HPY06_RS14105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_RS14105	COG4191	Histidine kinase
HPY06_RS14115	COG1757	Na H antiporter
HPY06_RS14120	COG2814	Major facilitator Superfamily
HPY06_RS14130	COG3240	lipase activity
HPY06_RS14140	COG0840	transmembrane signaling receptor activity
HPY06_RS14145	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY06_RS14150	COG5380	lipid catabolic process
HPY06_RS14175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_RS14180	COG4605	iron ion homeostasis
HPY06_RS14185	COG4604	ABC transporter, ATP-binding protein
HPY06_RS14190	COG2207	Transcriptional regulator
HPY06_RS14205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY06_RS14220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY06_RS14230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_RS14240	COG0583	DNA-binding transcription factor activity
HPY06_RS14260	COG0745	RESPONSE REGULATOR receiver
HPY06_RS14270	COG3623	hexulose-6-phosphate isomerase
HPY06_RS14275	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY06_RS14280	COG0561	phosphatase activity
HPY06_RS14330	COG0745	RESPONSE REGULATOR receiver
HPY06_RS14335	COG5002	protein histidine kinase activity
HPY06_RS14360	COG0583	DNA-binding transcription factor activity
HPY06_RS14375	COG1686	Belongs to the peptidase S11 family
HPY06_RS14395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY06_RS14395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY06_RS14400	COG0509	glycine decarboxylation via glycine cleavage system
HPY06_RS14405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY06_RS14415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPY06_RS14430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY06_RS14435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY06_RS14530	COG0454	-acetyltransferase
HPY06_RS14545	COG0456	acetyltransferase
HPY06_RS14685	COG5642	Protein of unknown function (DUF2384)
HPY06_RS14785	COG0456	acetyltransferase
HPY06_RS14815	COG0456	acetyltransferase
HPY06_RS14830	COG3549	Plasmid maintenance system killer
HPY06_RS14835	COG3093	addiction module antidote protein HigA
HPY06_RS15025	COG1418	mRNA catabolic process
HPY06_RS15070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPY06_RS15090	COG0454	-acetyltransferase
HPY06_RS15125	COG0454	-acetyltransferase
HPY06_RS15215	COG0653	protein targeting
HPY06_RS15230	COG2801	Transposase and inactivated derivatives
HPY06_RS15240	COG3158	transport of potassium into the cell
HPY06_RS15245	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY06_RS15245	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY06_RS15245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY06_RS15245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY06_RS15250	COG2205	protein histidine kinase activity
HPY06_RS15255	COG0745	RESPONSE REGULATOR receiver
HPY06_RS15260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY06_RS15265	COG0586	Pfam SNARE associated Golgi protein
HPY06_RS15275	COG2200	EAL domain
HPY06_RS15285	COG3038	cytochrome b561
HPY06_RS15295	COG2116	formate transmembrane transporter activity
HPY06_RS15300	COG0583	DNA-binding transcription factor activity
HPY06_RS15310	COG3593	DNA synthesis involved in DNA repair
HPY06_RS15315	COG0737	Belongs to the 5'-nucleotidase family
HPY06_RS15330	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY06_RS15380	COG3706	GGDEF domain
HPY06_RS15395	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY06_RS15400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY06_RS15410	COG0745	RESPONSE REGULATOR receiver
HPY06_RS15425	COG3140	Belongs to the UPF0181 family
HPY06_RS15495	COG0023	Translation Initiation Factor
HPY06_RS15515	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY06_RS15515	COG1042	CoA-binding domain protein
HPY06_RS15515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_RS15520	COG0583	DNA-binding transcription factor activity
HPY06_RS15525	COG4771	TonB-dependent receptor
HPY06_RS15540	COG2050	protein possibly involved in aromatic compounds catabolism
HPY06_RS15560	COG0625	glutathione transferase activity
HPY06_RS15575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY06_RS15580	COG4172	Belongs to the ABC transporter superfamily
HPY06_RS15585	COG4239	(ABC) transporter, permease
HPY06_RS15590	COG4174	ABC transporter (Permease)
HPY06_RS15595	COG4166	transmembrane transport
HPY06_RS15620	COG3104	oligopeptide transport
HPY06_RS15640	COG3842	ATPase activity
HPY06_RS15650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY06_RS15660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY06_RS15665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY06_RS15670	COG1011	Hydrolase
HPY06_RS15680	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY06_RS15685	COG1970	mechanosensitive ion channel activity
HPY06_RS15690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY06_RS15695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_RS15695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY06_RS15700	COG0302	gtp cyclohydrolase
HPY06_RS15710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY06_RS15720	COG2897	thiosulfate sulfurtransferase activity
HPY06_RS15725	COG2390	Transcriptional regulator
HPY06_RS15740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY06_RS15770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY06_RS15795	COG0583	DNA-binding transcription factor activity
HPY06_RS15800	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY06_RS15840	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY06_RS15885	COG1263	PTS System
HPY06_RS15885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY06_RS15895	COG1621	beta-fructofuranosidase activity
HPY06_RS15900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_RS15905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY06_RS15915	COG2885	chlorophyll binding
HPY06_RS15920	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY06_RS15990	COG0384	phenazine biosynthesis protein PhzF
HPY06_RS16000	COG3093	addiction module antidote protein HigA
HPY06_RS16005	COG3549	Plasmid maintenance system killer
HPY06_RS16010	COG4977	sequence-specific DNA binding
HPY06_RS16055	COG4115	mRNA cleavage
HPY06_RS16060	COG2161	toxin-antitoxin pair type II binding
HPY06_RS16085	COG3040	lipid binding
HPY06_RS16150	COG0494	nUDIX hydrolase
HPY06_RS16175	COG3093	addiction module antidote protein HigA
HPY06_RS16180	COG3549	Plasmid maintenance system killer
HPY06_RS16200	COG3041	Addiction module toxin RelE StbE family
HPY06_RS16365	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY06_RS16395	COG2801	Transposase and inactivated derivatives
HPY06_RS16400	COG0523	cobalamin synthesis protein
HPY06_RS16405	COG0038	chloride channel
HPY06_RS16415	COG0156	8-amino-7-oxononanoate synthase activity
HPY06_RS16420	COG2205	protein histidine kinase activity
HPY06_RS16420	COG0784	Response regulator, receiver
HPY06_RS16425	COG0419	ATPase involved in DNA repair
HPY06_RS16430	COG0420	3'-5' exonuclease activity
HPY06_RS16435	COG1609	Transcriptional regulator
HPY06_RS16440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_RS16440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_RS16445	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY06_RS16450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_RS16450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY06_RS16450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY06_RS16455	COG0189	ligase activity
HPY06_RS16455	COG4067	protein conserved in archaea
HPY06_RS16465	COG0602	queuosine metabolic process
HPY06_RS16470	COG1328	CTP reductase activity
HPY06_RS16480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY06_RS16485	COG0840	transmembrane signaling receptor activity
HPY06_RS16490	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY06_RS16495	COG1760	l-serine dehydratase
HPY06_RS16500	COG2197	response regulator
HPY06_RS16505	COG3850	Histidine kinase
HPY06_RS16510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY06_RS16520	COG0243	molybdopterin cofactor binding
HPY06_RS16540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY06_RS16545	COG2197	response regulator
HPY06_RS16550	COG3851	Histidine kinase
HPY06_RS16555	COG2271	Major facilitator Superfamily
HPY06_RS16560	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY06_RS16570	COG3842	ATPase activity
HPY06_RS16575	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY06_RS16585	COG0183	Belongs to the thiolase family
HPY06_RS16595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_RS16600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY06_RS16615	COG3706	GGDEF domain
HPY06_RS16620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY06_RS16630	COG1979	alcohol dehydrogenase
HPY06_RS16645	COG4191	Histidine kinase
HPY06_RS16655	COG2271	Major facilitator Superfamily
HPY06_RS16660	COG0469	pyruvate kinase activity
HPY06_RS16665	COG0784	Response regulator, receiver
HPY06_RS16665	COG2198	Histidine kinase
HPY06_RS16665	COG2205	protein histidine kinase activity
HPY06_RS16670	COG1879	ABC-type sugar transport system periplasmic component
HPY06_RS16675	COG1803	Methylglyoxal synthase
HPY06_RS16680	COG1335	isochorismatase
HPY06_RS16685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY06_RS16700	COG0210	DNA helicase
HPY06_RS16705	COG1289	transmembrane transporter activity
HPY06_RS16735	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY06_RS16740	COG4149	molybdate abc transporter
HPY06_RS16745	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY06_RS16750	COG1492	cobalamin metabolic process
HPY06_RS16790	COG1917	Cupin 2, conserved barrel domain protein
HPY06_RS16790	COG4977	sequence-specific DNA binding
HPY06_RS16800	COG2814	Major facilitator Superfamily
HPY06_RS16805	COG2226	methyltransferase
HPY06_RS16805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY06_RS16805	COG3433	isochorismatase activity
HPY06_RS16830	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY06_RS16835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY06_RS16855	COG1132	(ABC) transporter
HPY06_RS16860	COG1132	(ABC) transporter
HPY06_RS16870	COG5002	protein histidine kinase activity
HPY06_RS16870	COG0784	Response regulator, receiver
HPY06_RS16875	COG1879	ABC-type sugar transport system periplasmic component
HPY06_RS16885	COG2827	Endonuclease containing a URI domain
HPY06_RS16890	COG3132	Protein of unknown function, DUF480
HPY06_RS16900	COG2926	Belongs to the UPF0265 family
HPY06_RS16910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPY06_RS16915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY06_RS16920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY06_RS16930	COG0247	lactate metabolic process
HPY06_RS16935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY06_RS16940	COG3118	belongs to the thioredoxin family
HPY06_RS16965	COG4160	amino acid transport
HPY06_RS16970	COG4215	(ABC) transporter
HPY06_RS16975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_RS16980	COG1126	abc transporter atp-binding protein
HPY06_RS16990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY06_RS17000	COG0494	nUDIX hydrolase
HPY06_RS17005	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY06_RS17015	COG1309	transcriptional regulator
HPY06_RS17020	COG0513	Belongs to the DEAD box helicase family
HPY06_RS17025	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY06_RS17030	COG0814	amino acid
HPY06_RS17035	COG0840	transmembrane signaling receptor activity
HPY06_RS17040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY06_RS17045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY06_RS17055	COG1984	allophanate hydrolase subunit 2
HPY06_RS17070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY06_RS17075	COG4181	ATPase activity
HPY06_RS17085	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY06_RS17090	COG5001	Diguanylate cyclase
HPY06_RS17090	COG1716	ATPase activity
HPY06_RS17100	COG0484	heat shock protein binding
HPY06_RS17115	COG0546	phosphoglycolate phosphatase activity
HPY06_RS17130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_RS17140	COG0513	Belongs to the DEAD box helicase family
HPY06_RS17155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY06_RS17165	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY06_RS17170	COG3397	chitin binding
HPY06_RS17175	COG3227	Zinc metalloprotease (Elastase)
HPY06_RS17185	COG0010	Belongs to the arginase family
HPY06_RS17190	COG1166	arginine decarboxylase activity
HPY06_RS17200	COG2239	Acts as a magnesium transporter
HPY06_RS17210	COG0527	aspartate kinase activity
HPY06_RS17215	COG0662	Cupin 2, conserved barrel domain protein
HPY06_RS17220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY06_RS17225	COG0456	acetyltransferase
HPY06_RS17230	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY06_RS17235	COG3186	Phenylalanine-4-hydroxylase
HPY06_RS17240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY06_RS17255	COG2264	protein methyltransferase activity
HPY06_RS17280	COG1253	flavin adenine dinucleotide binding
HPY06_RS17285	COG1765	OsmC-like protein
HPY06_RS17315	COG1252	NADH dehydrogenase
HPY06_RS17320	COG0531	amino acid
HPY06_RS17325	COG3706	GGDEF domain
HPY06_RS17335	COG3279	Response regulator of the LytR AlgR family
HPY06_RS17340	COG3275	phosphorelay sensor kinase activity
HPY06_RS17355	COG1136	(ABC) transporter
HPY06_RS17355	COG0577	efflux transmembrane transporter activity
HPY06_RS17360	COG1136	(ABC) transporter
HPY06_RS17370	COG4989	oxidoreductase activity
HPY06_RS17375	COG0366	Alpha amylase catalytic
HPY06_RS17385	COG2067	long-chain fatty acid transport protein
HPY06_RS17390	COG2267	carboxylic ester hydrolase activity
HPY06_RS17400	COG3227	Zinc metalloprotease (Elastase)
HPY06_RS17405	COG3047	cAMP biosynthetic process
HPY06_RS17415	COG1686	Belongs to the peptidase S11 family
HPY06_RS17420	COG0557	exoribonuclease II activity
HPY06_RS17425	COG1278	Cold shock
HPY06_RS17435	COG3048	D-serine ammonia-lyase activity
HPY06_RS17440	COG0583	DNA-binding transcription factor activity
HPY06_RS17455	COG2801	Transposase and inactivated derivatives
HPY06_RS17485	COG1063	alcohol dehydrogenase
HPY06_RS17490	COG0156	8-amino-7-oxononanoate synthase activity
HPY06_RS17510	COG0346	lactoylglutathione lyase activity
HPY06_RS17530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY06_RS17535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY06_RS17540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY06_RS17545	COG0363	glucosamine-6-phosphate deaminase activity
HPY06_RS17550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY06_RS17575	COG1929	Belongs to the glycerate kinase type-1 family
HPY06_RS17580	COG2610	gluconate transmembrane transporter activity
HPY06_RS17585	COG3835	regulator
HPY06_RS17595	COG0748	coenzyme F420 binding
HPY06_RS17600	COG3721	Heme iron utilization protein
HPY06_RS17610	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY06_RS17615	COG0811	peptide transport
HPY06_RS17620	COG0848	biopolymer transport protein
HPY06_RS17625	COG4558	Periplasmic binding protein
HPY06_RS17630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY06_RS17635	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY06_RS17670	COG3217	Mosc domain protein beta barrel domain protein
HPY06_RS17670	COG0633	Ferredoxin
HPY06_RS17670	COG3217	Mosc domain protein beta barrel domain protein
HPY06_RS17670	COG0633	Ferredoxin
HPY06_RS17675	COG0418	dihydroorotase activity
HPY06_RS17680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY06_RS17685	COG2354	Protein conserved in bacteria
HPY06_RS17695	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY06_RS17700	COG1278	Cold shock
HPY06_RS17725	COG3706	GGDEF domain
HPY06_RS17730	COG1349	DNA-binding transcription factor activity
HPY06_RS17745	COG3833	ABC-type maltose transport systems, permease component
HPY06_RS17750	COG1175	transmembrane transport
HPY06_RS17760	COG3842	ATPase activity
HPY06_RS17765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY06_RS17780	COG0393	Putative heavy-metal-binding
HPY06_RS17790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY06_RS17795	COG0784	Response regulator, receiver
HPY06_RS17795	COG0835	chemotaxis
HPY06_RS17800	COG1846	Transcriptional regulator
HPY06_RS17840	COG0583	DNA-binding transcription factor activity
HPY06_RS17845	COG5001	Diguanylate cyclase
HPY06_RS17855	COG1741	Belongs to the pirin family
HPY06_RS17860	COG3123	guanosine phosphorylase activity
HPY06_RS17870	COG2211	Major facilitator Superfamily
HPY06_RS17875	COG0840	transmembrane signaling receptor activity
HPY06_RS17880	COG1067	ATP-dependent peptidase activity
HPY06_RS17890	COG4172	Belongs to the ABC transporter superfamily
HPY06_RS17910	COG0583	DNA-binding transcription factor activity
HPY06_RS17920	COG1620	l-lactate permease
HPY06_RS17935	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY06_RS17945	COG0840	transmembrane signaling receptor activity
HPY06_RS17965	COG2258	MOSC domain
HPY06_RS17970	COG0513	Belongs to the DEAD box helicase family
HPY06_RS17980	COG2186	Transcriptional regulator
HPY06_RS17990	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY06_RS18000	COG0246	Mannitol dehydrogenase
HPY06_RS18005	COG1904	glucuronate isomerase
HPY06_RS18010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY06_RS18015	COG0800	Aldolase
HPY06_RS18025	COG0583	DNA-binding transcription factor activity
HPY06_RS18035	COG1902	pentaerythritol trinitrate reductase activity
HPY06_RS18045	COG1132	(ABC) transporter
HPY06_RS18055	COG1902	pentaerythritol trinitrate reductase activity
HPY06_RS18065	COG1280	lysine exporter protein (LysE YggA)
HPY06_RS18070	COG2207	Transcriptional regulator
HPY06_RS18090	COG1846	Transcriptional regulator
HPY06_RS18095	COG1764	response to oxidative stress
HPY06_RS18100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY06_RS18105	COG0697	spore germination
HPY06_RS18115	COG0700	Nucleoside recognition
HPY06_RS18120	COG3366	ferrous iron transmembrane transporter activity
HPY06_RS18125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY06_RS18135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY06_RS18140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY06_RS18145	COG2259	Doxx family
HPY06_RS18170	COG0363	glucosamine-6-phosphate deaminase activity
HPY06_RS18185	COG4580	involved in the transport of maltose and maltodextrins
HPY06_RS18200	COG0840	transmembrane signaling receptor activity
HPY06_RS18210	COG0840	transmembrane signaling receptor activity
HPY06_RS18215	COG3706	GGDEF domain
HPY06_RS18225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY06_RS18230	COG1126	abc transporter atp-binding protein
HPY06_RS18240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY06_RS18245	COG4597	amino acid ABC transporter
HPY06_RS18250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY06_RS18255	COG2213	PTS system mannitol-specific
HPY06_RS18255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY06_RS18260	COG0246	Mannitol dehydrogenase
HPY06_RS18265	COG3722	fumarate hydratase activity
HPY06_RS18300	COG2910	NAD(P)H-binding
HPY06_RS18310	COG0840	transmembrane signaling receptor activity
HPY06_RS18315	COG4221	oxidoreductase activity
HPY06_RS18325	COG1901	pseudouridine methyltransferase
HPY06_RS18335	COG0531	amino acid
HPY06_RS18340	COG1982	Orn Lys Arg decarboxylase major
HPY06_RS18350	COG2197	response regulator
HPY06_RS18390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY06_RS18415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY06_RS18480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY06_RS18485	COG0840	transmembrane signaling receptor activity
HPY06_RS18490	COG0835	chemotaxis
HPY06_RS18495	COG0835	chemotaxis
HPY06_RS18500	COG2198	Histidine kinase
HPY06_RS18500	COG0643	Histidine kinase
HPY06_RS18520	COG0601	transmembrane transport
HPY06_RS18525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY06_RS18530	COG4608	Belongs to the ABC transporter superfamily
HPY06_RS18535	COG2194	sulfuric ester hydrolase activity
HPY06_RS18540	COG0642	Histidine kinase
HPY06_RS18545	COG0745	RESPONSE REGULATOR receiver
HPY06_RS18575	COG1444	tRNA N-acetyltransferase activity
HPY06_RS18580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine