locus-tag	class	description
Sa5Y_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Sa5Y_RS00010	COG0592	DNA-directed DNA polymerase activity
Sa5Y_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Sa5Y_RS00020	COG0187	DNA topoisomerase II activity
Sa5Y_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
Sa5Y_RS00060	COG2119	membrane
Sa5Y_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
Sa5Y_RS00085	COG0604	alcohol dehydrogenase
Sa5Y_RS00095	COG0129	dihydroxy-acid dehydratase activity
Sa5Y_RS00100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sa5Y_RS00115	COG0606	chelatase, subunit chli
Sa5Y_RS00120	COG0204	Acyl-transferase
Sa5Y_RS00125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa5Y_RS00130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Sa5Y_RS00140	COG3084	Protein conserved in bacteria
Sa5Y_RS00150	COG4326	sporulation control protein
Sa5Y_RS00155	COG1272	protein, Hemolysin III
Sa5Y_RS00165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Sa5Y_RS00170	COG0569	domain protein
Sa5Y_RS00175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sa5Y_RS00175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sa5Y_RS00180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Sa5Y_RS00185	COG0242	peptide deformylase activity
Sa5Y_RS00190	COG1652	LysM domain
Sa5Y_RS00195	COG0758	DNA mediated transformation
Sa5Y_RS00200	COG2922	Belongs to the Smg family
Sa5Y_RS00205	COG0551	DNA topoisomerase type I activity
Sa5Y_RS00210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Sa5Y_RS00215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Sa5Y_RS00220	COG0009	L-threonylcarbamoyladenylate synthase
Sa5Y_RS00225	COG0408	coproporphyrinogen oxidase activity
Sa5Y_RS00230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Sa5Y_RS00240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Sa5Y_RS00280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Sa5Y_RS00285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Sa5Y_RS00295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Sa5Y_RS00300	COG2104	thiamine diphosphate biosynthetic process
Sa5Y_RS00305	COG2022	thiamine diphosphate biosynthetic process
Sa5Y_RS00310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sa5Y_RS00315	COG0006	proline dipeptidase activity
Sa5Y_RS00315	COG0006	proline dipeptidase activity
Sa5Y_RS00335	COG1522	sequence-specific DNA binding
Sa5Y_RS00340	COG5002	protein histidine kinase activity
Sa5Y_RS00340	COG5001	Diguanylate cyclase
Sa5Y_RS00360	COG0589	response to stress
Sa5Y_RS00370	COG1528	Iron-storage protein
Sa5Y_RS00380	COG2081	HI0933 family
Sa5Y_RS00390	COG1322	Protein conserved in bacteria
Sa5Y_RS00395	COG2226	methyltransferase
Sa5Y_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sa5Y_RS00415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sa5Y_RS00420	COG0805	protein transport
Sa5Y_RS00425	COG1858	cytochrome C peroxidase
Sa5Y_RS00430	COG0534	Mate efflux family protein
Sa5Y_RS00440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Sa5Y_RS00450	COG2937	Belongs to the GPAT DAPAT family
Sa5Y_RS00455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sa5Y_RS00460	COG3161	chorismate lyase activity
Sa5Y_RS00470	COG1580	Controls the rotational direction of flagella during chemotaxis
Sa5Y_RS00475	COG0840	transmembrane signaling receptor activity
Sa5Y_RS00485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Sa5Y_RS00495	COG0084	hydrolase, TatD family'
Sa5Y_RS00515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sa5Y_RS00515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sa5Y_RS00535	COG3078	GTPase activator activity
Sa5Y_RS00550	COG3071	HemY protein
Sa5Y_RS00555	COG2959	enzyme of heme biosynthesis
Sa5Y_RS00560	COG1587	Uroporphyrinogen-III synthase
Sa5Y_RS00565	COG0181	hydroxymethylbilane synthase activity
Sa5Y_RS00580	COG1965	Belongs to the frataxin family
Sa5Y_RS00590	COG0019	diaminopimelate decarboxylase activity
Sa5Y_RS00595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Sa5Y_RS00605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Sa5Y_RS00610	COG1011	Hydrolase
Sa5Y_RS00615	COG3287	FIST C domain
Sa5Y_RS00615	COG2200	EAL domain
Sa5Y_RS00615	COG2199	diguanylate cyclase activity
Sa5Y_RS00635	COG0561	phosphatase activity
Sa5Y_RS00640	COG2267	carboxylic ester hydrolase activity
Sa5Y_RS00645	COG1280	lysine exporter protein (LysE YggA)
Sa5Y_RS00650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Sa5Y_RS00655	COG0783	Belongs to the Dps family
Sa5Y_RS00695	COG0742	ribosomal rna small subunit methyltransferase
Sa5Y_RS00700	COG0552	protein localization to endoplasmic reticulum
Sa5Y_RS00705	COG2884	Cell division ATP-binding protein ftsE
Sa5Y_RS00710	COG2177	Part of the ABC transporter FtsEX involved in
Sa5Y_RS00715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sa5Y_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa5Y_RS00740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Sa5Y_RS00745	COG4206	TonB-dependent receptor
Sa5Y_RS00750	COG1404	Belongs to the peptidase S8 family
Sa5Y_RS00755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sa5Y_RS00820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Sa5Y_RS00825	COG5001	Diguanylate cyclase
Sa5Y_RS00825	COG3300	MHYT domain
Sa5Y_RS00835	COG3852	Histidine kinase
Sa5Y_RS00845	COG0174	glutamine synthetase
Sa5Y_RS00855	COG1217	gtp-binding protein TYPA
Sa5Y_RS00860	COG1660	Displays ATPase and GTPase activities
Sa5Y_RS00865	COG1295	ribonuclease BN
Sa5Y_RS00870	COG1490	D-aminoacyl-tRNA deacylase activity
Sa5Y_RS00875	COG0456	acetyltransferase
Sa5Y_RS00885	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Sa5Y_RS00890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Sa5Y_RS00895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Sa5Y_RS00900	COG3031	protein transport across the cell outer membrane
Sa5Y_RS00910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sa5Y_RS00915	COG1459	type II secretion system
Sa5Y_RS00920	COG2165	general secretion pathway protein
Sa5Y_RS00925	COG2165	general secretion pathway protein
Sa5Y_RS00930	COG2165	general secretion pathway protein
Sa5Y_RS00935	COG4795	General secretion pathway protein
Sa5Y_RS00940	COG3156	type II secretion system protein K
Sa5Y_RS00945	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Sa5Y_RS00950	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Sa5Y_RS00960	COG1218	3'(2'),5'-bisphosphate nucleotidase
Sa5Y_RS00965	COG0494	nUDIX hydrolase
Sa5Y_RS00975	COG1040	competence protein
Sa5Y_RS00980	COG0596	Alpha beta hydrolase
Sa5Y_RS00990	COG2183	response to ionizing radiation
Sa5Y_RS00995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sa5Y_RS01010	COG2233	PERMEase
Sa5Y_RS01015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Sa5Y_RS01020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Sa5Y_RS01025	COG1758	RNA polymerase activity
Sa5Y_RS01030	COG0194	GDP metabolic process
Sa5Y_RS01035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Sa5Y_RS01040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Sa5Y_RS01060	COG4232	protein-disulfide reductase activity
Sa5Y_RS01070	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Sa5Y_RS01075	COG1027	Aspartate ammonia-lyase
Sa5Y_RS01080	COG3706	GGDEF domain
Sa5Y_RS01085	COG3030	protein affecting phage T7 exclusion by the F plasmid
Sa5Y_RS01090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Sa5Y_RS01100	COG2205	protein histidine kinase activity
Sa5Y_RS01105	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS01115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Sa5Y_RS01120	COG0205	6-phosphofructokinase activity
Sa5Y_RS01125	COG1494	fructose-1,6-bisphosphatase
Sa5Y_RS01130	COG3074	FtsZ-dependent cytokinesis
Sa5Y_RS01135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Sa5Y_RS01140	COG0527	aspartate kinase activity
Sa5Y_RS01140	COG0460	homoserine dehydrogenase
Sa5Y_RS01145	COG0626	cystathionine gamma-synthase activity
Sa5Y_RS01150	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
Sa5Y_RS01155	COG0281	malic enzyme
Sa5Y_RS01160	COG0254	rRNA binding
Sa5Y_RS01165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Sa5Y_RS01170	COG1609	Transcriptional regulator
Sa5Y_RS01175	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Sa5Y_RS01180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Sa5Y_RS01185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Sa5Y_RS01190	COG1575	Belongs to the MenA family. Type 1 subfamily
Sa5Y_RS01195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa5Y_RS01200	COG0534	Mate efflux family protein
Sa5Y_RS01205	COG0149	triose-phosphate isomerase activity
Sa5Y_RS01235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Sa5Y_RS01240	COG0459	protein refolding
Sa5Y_RS01260	COG1509	lysine 2,3-aminomutase activity
Sa5Y_RS01265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Sa5Y_RS01275	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Sa5Y_RS01280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Sa5Y_RS01285	COG1053	succinate dehydrogenase
Sa5Y_RS01290	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Sa5Y_RS01295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Sa5Y_RS01300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Sa5Y_RS01305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Sa5Y_RS01310	COG1045	serine acetyltransferase
Sa5Y_RS01320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Sa5Y_RS01325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sa5Y_RS01330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Sa5Y_RS01335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Sa5Y_RS01340	COG0137	argininosuccinate synthase activity
Sa5Y_RS01350	COG0165	Argininosuccinate lyase
Sa5Y_RS01360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa5Y_RS01365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Sa5Y_RS01365	COG0678	peroxiredoxin activity
Sa5Y_RS01375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Sa5Y_RS01405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Sa5Y_RS01410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Sa5Y_RS01420	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Sa5Y_RS01425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Sa5Y_RS01430	COG0546	phosphoglycolate phosphatase activity
Sa5Y_RS01435	COG0180	Tryptophanyl-tRNA synthetase
Sa5Y_RS01450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sa5Y_RS01460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Sa5Y_RS01470	COG1012	belongs to the aldehyde dehydrogenase family
Sa5Y_RS01485	COG3954	Phosphoribulokinase
Sa5Y_RS01495	COG0429	hydrolase of the alpha beta-hydrolase fold
Sa5Y_RS01505	COG0488	(ABC) transporter
Sa5Y_RS01510	COG2249	NAD(P)H dehydrogenase (quinone) activity
Sa5Y_RS01525	COG1047	Peptidyl-prolyl cis-trans
Sa5Y_RS01530	COG1446	asparaginase
Sa5Y_RS01535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Sa5Y_RS01545	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
Sa5Y_RS01550	COG3083	sulfuric ester hydrolase activity
Sa5Y_RS01555	COG0557	exoribonuclease II activity
Sa5Y_RS01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sa5Y_RS01565	COG0051	transcription antitermination factor activity, RNA binding
Sa5Y_RS01570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Sa5Y_RS01575	COG0088	Forms part of the polypeptide exit tunnel
Sa5Y_RS01580	COG0089	rRNA binding
Sa5Y_RS01585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Sa5Y_RS01590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Sa5Y_RS01595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Sa5Y_RS01600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Sa5Y_RS01605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Sa5Y_RS01610	COG0255	Belongs to the universal ribosomal protein uL29 family
Sa5Y_RS01615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Sa5Y_RS01620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Sa5Y_RS01625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Sa5Y_RS01630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Sa5Y_RS01635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Sa5Y_RS01640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Sa5Y_RS01645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Sa5Y_RS01650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Sa5Y_RS01655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Sa5Y_RS01660	COG1841	ribosomal large subunit assembly
Sa5Y_RS01670	COG0201	protein transport
Sa5Y_RS01675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Sa5Y_RS01680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Sa5Y_RS01685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Sa5Y_RS01690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Sa5Y_RS01695	COG0202	RNA polymerase activity
Sa5Y_RS01700	COG0203	ribosomal protein L17
Sa5Y_RS01710	COG0545	Peptidyl-prolyl cis-trans isomerase
Sa5Y_RS01715	COG3061	Opacity-associated protein A
Sa5Y_RS01715	COG3266	domain, Protein
Sa5Y_RS01720	COG0697	spore germination
Sa5Y_RS01725	COG2153	protein acetylation
Sa5Y_RS01730	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS01740	COG0737	Belongs to the 5'-nucleotidase family
Sa5Y_RS01745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Sa5Y_RS01745	COG1648	precorrin-2 dehydrogenase activity
Sa5Y_RS01750	COG0175	sulfate reduction
Sa5Y_RS01755	COG2895	sulfate adenylyltransferase (ATP) activity
Sa5Y_RS01760	COG0529	Catalyzes the synthesis of activated sulfate
Sa5Y_RS01780	COG1136	(ABC) transporter
Sa5Y_RS01795	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Sa5Y_RS01800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa5Y_RS01805	COG0729	surface antigen
Sa5Y_RS01815	COG2105	PFAM AIG2 family protein
Sa5Y_RS01820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Sa5Y_RS01835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Sa5Y_RS01840	COG0163	prenyltransferase activity
Sa5Y_RS01850	COG1178	ABC-type Fe3 transport system permease component
Sa5Y_RS01855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Sa5Y_RS01860	COG3028	Belongs to the UPF0307 family
Sa5Y_RS01865	COG0312	modulator of DNA gyrase
Sa5Y_RS01870	COG2239	Acts as a magnesium transporter
Sa5Y_RS01875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa5Y_RS01880	COG1660	Displays ATPase and GTPase activities
Sa5Y_RS01885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa5Y_RS01890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Sa5Y_RS01900	COG1137	ATPase activity
Sa5Y_RS01905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Sa5Y_RS01920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Sa5Y_RS01920	COG0517	IMP dehydrogenase activity
Sa5Y_RS01935	COG1127	ABC transporter
Sa5Y_RS01940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Sa5Y_RS01945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Sa5Y_RS01950	COG2854	intermembrane phospholipid transfer
Sa5Y_RS01960	COG5007	Belongs to the BolA IbaG family
Sa5Y_RS01965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sa5Y_RS01975	COG0251	oxidation-reduction process
Sa5Y_RS01985	COG0540	Belongs to the ATCase OTCase family
Sa5Y_RS01995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Sa5Y_RS02010	COG0564	pseudouridine synthase activity
Sa5Y_RS02015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa5Y_RS02020	COG0525	valine-tRNA ligase activity
Sa5Y_RS02025	COG2927	DNA polymerase III (CHI subunit)
Sa5Y_RS02030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Sa5Y_RS02035	COG0795	lipopolysaccharide-transporting ATPase activity
Sa5Y_RS02040	COG0795	lipopolysaccharide-transporting ATPase activity
Sa5Y_RS02055	COG3437	response regulator, receiver
Sa5Y_RS02100	COG0066	3-isopropylmalate dehydratase activity
Sa5Y_RS02105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Sa5Y_RS02110	COG0473	3-isopropylmalate dehydrogenase activity
Sa5Y_RS02135	COG0583	DNA-binding transcription factor activity
Sa5Y_RS02140	COG1022	Amp-dependent synthetase and ligase
Sa5Y_RS02145	COG0028	Belongs to the TPP enzyme family
Sa5Y_RS02150	COG0440	acetolactate synthase activity
Sa5Y_RS02160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sa5Y_RS02165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Sa5Y_RS02170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Sa5Y_RS02180	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Sa5Y_RS02185	COG3079	Belongs to the UPF0149 family
Sa5Y_RS02190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa5Y_RS02195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa5Y_RS02210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Sa5Y_RS02220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Sa5Y_RS02230	COG1595	DNA-templated transcription, initiation
Sa5Y_RS02245	COG3086	response to oxidative stress
Sa5Y_RS02250	COG0481	GTPase activity
Sa5Y_RS02260	COG0571	ribonuclease III activity
Sa5Y_RS02265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Sa5Y_RS02270	COG1381	Involved in DNA repair and RecF pathway recombination
Sa5Y_RS02275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Sa5Y_RS02280	COG0736	holo-[acyl-carrier-protein] synthase activity
Sa5Y_RS02305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Sa5Y_RS02310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Sa5Y_RS02315	COG3956	TIGRFAM MazG family protein
Sa5Y_RS02320	COG0504	CTP synthase activity
Sa5Y_RS02325	COG0148	phosphopyruvate hydratase activity
Sa5Y_RS02330	COG0617	tRNA 3'-terminal CCA addition
Sa5Y_RS02345	COG4991	sh3 domain protein
Sa5Y_RS02350	COG0306	phosphate transporter
Sa5Y_RS02355	COG1392	Phosphate transport regulator
Sa5Y_RS02360	COG3025	triphosphatase activity
Sa5Y_RS02370	COG0840	transmembrane signaling receptor activity
Sa5Y_RS02375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Sa5Y_RS02385	COG1538	Outer membrane efflux protein
Sa5Y_RS02390	COG0494	nUDIX hydrolase
Sa5Y_RS02395	COG3151	Protein conserved in bacteria
Sa5Y_RS02405	COG3150	esterase
Sa5Y_RS02410	COG0187	DNA topoisomerase II activity
Sa5Y_RS02415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Sa5Y_RS02430	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Sa5Y_RS02435	COG0237	dephospho-CoA kinase activity
Sa5Y_RS02445	COG1459	type II secretion system
Sa5Y_RS02450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sa5Y_RS02460	COG0157	Belongs to the NadC ModD family
Sa5Y_RS02475	COG0716	FMN binding
Sa5Y_RS02480	COG4974	Belongs to the 'phage' integrase family
Sa5Y_RS02485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa5Y_RS02490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Sa5Y_RS02500	COG2186	Transcriptional regulator
Sa5Y_RS02505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Sa5Y_RS02510	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa5Y_RS02515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa5Y_RS02530	COG3116	cell division
Sa5Y_RS02535	COG0768	penicillin binding
Sa5Y_RS02540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sa5Y_RS02545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Sa5Y_RS02555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Sa5Y_RS02560	COG0772	Belongs to the SEDS family
Sa5Y_RS02565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sa5Y_RS02570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Sa5Y_RS02575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Sa5Y_RS02580	COG0849	cell division
Sa5Y_RS02585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Sa5Y_RS02590	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Sa5Y_RS02600	COG0653	protein targeting
Sa5Y_RS02605	COG0494	nUDIX hydrolase
Sa5Y_RS02610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Sa5Y_RS02620	COG0505	Belongs to the CarA family
Sa5Y_RS02625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Sa5Y_RS02640	COG0730	response to heat
Sa5Y_RS02645	COG0583	DNA-binding transcription factor activity
Sa5Y_RS02650	COG2860	membrane
Sa5Y_RS02655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Sa5Y_RS02665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Sa5Y_RS02675	COG0493	'glutamate synthase
Sa5Y_RS02680	COG0067	glutamate synthase
Sa5Y_RS02680	COG0070	glutamate synthase
Sa5Y_RS02680	COG0069	glutamate synthase activity
Sa5Y_RS02690	COG0070	glutamate synthase
Sa5Y_RS02690	COG0069	glutamate synthase activity
Sa5Y_RS02690	COG0067	glutamate synthase
Sa5Y_RS02695	COG1242	4 iron, 4 sulfur cluster binding
Sa5Y_RS02700	COG5001	Diguanylate cyclase
Sa5Y_RS02700	COG4251	negative regulation of phosphorylation
Sa5Y_RS02700	COG3706	GGDEF domain
Sa5Y_RS02700	COG2203	Gaf domain
Sa5Y_RS02705	COG2198	Histidine kinase
Sa5Y_RS02705	COG0784	Response regulator, receiver
Sa5Y_RS02705	COG5002	protein histidine kinase activity
Sa5Y_RS02710	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS02720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa5Y_RS02740	COG0083	homoserine kinase activity
Sa5Y_RS02745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Sa5Y_RS02750	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Sa5Y_RS02755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Sa5Y_RS02760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Sa5Y_RS02775	COG1115	amino acid carrier protein
Sa5Y_RS02780	COG3022	response to hydroperoxide
Sa5Y_RS02785	COG0084	hydrolase, TatD family'
Sa5Y_RS02790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Sa5Y_RS02800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Sa5Y_RS02805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Sa5Y_RS02810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Sa5Y_RS02815	COG0813	purine-nucleoside phosphorylase activity
Sa5Y_RS02825	COG0560	Phosphoserine phosphatase
Sa5Y_RS02840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Sa5Y_RS02845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sa5Y_RS02850	COG1022	Amp-dependent synthetase and ligase
Sa5Y_RS02865	COG3250	beta-galactosidase activity
Sa5Y_RS02870	COG1609	Transcriptional regulator
Sa5Y_RS02875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa5Y_RS02890	COG0569	domain protein
Sa5Y_RS02890	COG0189	ligase activity
Sa5Y_RS02895	COG0456	acetyltransferase
Sa5Y_RS02905	COG2171	N-acyltransferase activity
Sa5Y_RS02910	COG3141	response to X-ray
Sa5Y_RS02925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Sa5Y_RS02930	COG1074	ATP-dependent DNA helicase activity
Sa5Y_RS02935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sa5Y_RS02945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Sa5Y_RS02945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Sa5Y_RS02955	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Sa5Y_RS02960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Sa5Y_RS02965	COG2166	iron-sulfur cluster assembly
Sa5Y_RS02970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sa5Y_RS02975	COG0693	protein deglycase activity
Sa5Y_RS02980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Sa5Y_RS02995	COG1595	DNA-templated transcription, initiation
Sa5Y_RS03005	COG2211	Major facilitator Superfamily
Sa5Y_RS03020	COG2813	Specifically methylates the guanine in position
Sa5Y_RS03025	COG0271	Belongs to the BolA IbaG family
Sa5Y_RS03030	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Sa5Y_RS03035	COG1805	sodium ion transport
Sa5Y_RS03040	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Sa5Y_RS03045	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Sa5Y_RS03050	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Sa5Y_RS03055	COG2871	sodium ion transport
Sa5Y_RS03060	COG1477	protein flavinylation
Sa5Y_RS03080	COG3706	GGDEF domain
Sa5Y_RS03085	COG0733	neurotransmitter:sodium symporter activity
Sa5Y_RS03095	COG0189	ligase activity
Sa5Y_RS03100	COG0189	ligase activity
Sa5Y_RS03100	COG4067	protein conserved in archaea
Sa5Y_RS03105	COG2195	Cleaves the N-terminal amino acid of tripeptides
Sa5Y_RS03110	COG2252	PERMEase
Sa5Y_RS03115	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Sa5Y_RS03120	COG1073	alpha beta
Sa5Y_RS03130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Sa5Y_RS03135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Sa5Y_RS03140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Sa5Y_RS03145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Sa5Y_RS03145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Sa5Y_RS03160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Sa5Y_RS03165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sa5Y_RS03170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Sa5Y_RS03175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Sa5Y_RS03190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Sa5Y_RS03195	COG0024	Methionine aminopeptidase
Sa5Y_RS03200	COG0052	Belongs to the universal ribosomal protein uS2 family
Sa5Y_RS03205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Sa5Y_RS03210	COG0528	UMP kinase activity
Sa5Y_RS03215	COG0233	cytoplasmic translational termination
Sa5Y_RS03220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Sa5Y_RS03225	COG0575	Belongs to the CDS family
Sa5Y_RS03230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Sa5Y_RS03235	COG0750	zinc metalloprotease
Sa5Y_RS03245	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Sa5Y_RS03250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa5Y_RS03255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sa5Y_RS03260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa5Y_RS03265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa5Y_RS03270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Sa5Y_RS03275	COG0587	DNA-directed DNA polymerase activity
Sa5Y_RS03280	COG0825	malonyl-CoA metabolic process
Sa5Y_RS03285	COG0037	tRNA processing
Sa5Y_RS03295	COG3479	Phenolic acid decarboxylase
Sa5Y_RS03300	COG0347	Belongs to the P(II) protein family
Sa5Y_RS03305	COG3021	interspecies interaction between organisms
Sa5Y_RS03310	COG1388	LysM domain
Sa5Y_RS03310	COG0741	lytic transglycosylase activity
Sa5Y_RS03315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa5Y_RS03320	COG2226	methyltransferase
Sa5Y_RS03325	COG0328	RNA-DNA hybrid ribonuclease activity
Sa5Y_RS03340	COG1960	acyl-CoA dehydrogenase activity
Sa5Y_RS03345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Sa5Y_RS03350	COG0121	glutamine amidotransferase
Sa5Y_RS03355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Sa5Y_RS03360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Sa5Y_RS03365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Sa5Y_RS03375	COG1187	pseudouridine synthase activity
Sa5Y_RS03380	COG2840	Smr protein MutS2
Sa5Y_RS03395	COG3735	TraB family
Sa5Y_RS03410	COG2217	Heavy metal translocating P-type atpase
Sa5Y_RS03410	COG2608	mercury ion transmembrane transporter activity
Sa5Y_RS03415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sa5Y_RS03430	COG4774	siderophore transport
Sa5Y_RS03430	COG1629	transport
Sa5Y_RS03435	COG2375	cellular response to nickel ion
Sa5Y_RS03440	COG3433	isochorismatase activity
Sa5Y_RS03440	COG2226	methyltransferase
Sa5Y_RS03440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Sa5Y_RS03475	COG0784	Response regulator, receiver
Sa5Y_RS03475	COG0835	chemotaxis
Sa5Y_RS03480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Sa5Y_RS03485	COG1815	bacterial-type flagellum-dependent cell motility
Sa5Y_RS03500	COG1749	Flagellar hook protein flgE
Sa5Y_RS03505	COG4787	bacterial-type flagellum-dependent cell motility
Sa5Y_RS03515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Sa5Y_RS03520	COG1706	bacterial-type flagellum-dependent cell motility
Sa5Y_RS03525	COG1705	Flagellar rod assembly protein muramidase FlgJ
Sa5Y_RS03525	COG3951	Flagellar rod assembly protein muramidase FlgJ
Sa5Y_RS03540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa5Y_RS03545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa5Y_RS03630	COG0012	GTP binding
Sa5Y_RS03635	COG0193	aminoacyl-tRNA hydrolase activity
Sa5Y_RS03640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Sa5Y_RS03650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Sa5Y_RS03655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Sa5Y_RS03660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Sa5Y_RS03665	COG2890	protein-(glutamine-N5) methyltransferase activity
Sa5Y_RS03675	COG2912	Transglutaminase-like superfamily
Sa5Y_RS03680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Sa5Y_RS03685	COG0737	Belongs to the 5'-nucleotidase family
Sa5Y_RS03690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Sa5Y_RS03695	COG2233	PERMEase
Sa5Y_RS03715	COG1393	Belongs to the ArsC family
Sa5Y_RS03720	COG4783	chaperone-mediated protein folding
Sa5Y_RS03740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Sa5Y_RS03755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Sa5Y_RS03765	COG1876	peptidase activity
Sa5Y_RS03775	COG1393	Belongs to the ArsC family
Sa5Y_RS03795	COG2837	iron assimilation
Sa5Y_RS03800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa5Y_RS03805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa5Y_RS03810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa5Y_RS03815	COG1334	flagellar protein FlaG
Sa5Y_RS03820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Sa5Y_RS03830	COG1516	flagellar protein fliS
Sa5Y_RS03850	COG1677	Flagellar hook-basal body complex protein FliE
Sa5Y_RS03860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sa5Y_RS03865	COG1317	bacterial-type flagellum organization
Sa5Y_RS03890	COG1580	Controls the rotational direction of flagella during chemotaxis
Sa5Y_RS03915	COG1987	bacterial-type flagellum assembly
Sa5Y_RS03920	COG1684	flagellar biosynthetic protein fliR
Sa5Y_RS03925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Sa5Y_RS03930	COG2840	Smr protein MutS2
Sa5Y_RS03935	COG2890	protein-(glutamine-N5) methyltransferase activity
Sa5Y_RS03945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Sa5Y_RS03950	COG2860	membrane
Sa5Y_RS03955	COG3101	peptidyl-lysine hydroxylation
Sa5Y_RS03965	COG0431	NADPH-dependent FMN reductase
Sa5Y_RS03970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa5Y_RS03970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Sa5Y_RS03975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sa5Y_RS03980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sa5Y_RS03985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sa5Y_RS03990	COG0735	belongs to the Fur family
Sa5Y_RS04000	COG0583	DNA-binding transcription factor activity
Sa5Y_RS04010	COG1346	cytolysis
Sa5Y_RS04025	COG0596	Alpha beta hydrolase
Sa5Y_RS04030	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Sa5Y_RS04035	COG0033	Phosphoglucomutase
Sa5Y_RS04045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Sa5Y_RS04050	COG0372	Belongs to the citrate synthase family
Sa5Y_RS04055	COG2009	succinate dehydrogenase
Sa5Y_RS04060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Sa5Y_RS04065	COG1053	succinate dehydrogenase
Sa5Y_RS04075	COG0567	Dehydrogenase, E1 component
Sa5Y_RS04080	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa5Y_RS04085	COG0045	succinate-CoA ligase (ADP-forming) activity
Sa5Y_RS04095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sa5Y_RS04100	COG1121	(ABC) transporter
Sa5Y_RS04105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Sa5Y_RS04110	COG4977	sequence-specific DNA binding
Sa5Y_RS04120	COG1918	ferrous iron import across plasma membrane
Sa5Y_RS04140	COG0018	arginyl-trna synthetase
Sa5Y_RS04150	COG1025	Belongs to the peptidase M16 family
Sa5Y_RS04155	COG2062	phosphohistidine phosphatase, SixA
Sa5Y_RS04185	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Sa5Y_RS04190	COG2198	Histidine kinase
Sa5Y_RS04190	COG0784	Response regulator, receiver
Sa5Y_RS04190	COG0643	Histidine kinase
Sa5Y_RS04195	COG2201	protein-glutamate methylesterase activity
Sa5Y_RS04200	COG1192	Involved in chromosome partitioning
Sa5Y_RS04210	COG0835	chemotaxis
Sa5Y_RS04220	COG4133	protoheme IX ABC transporter activity
Sa5Y_RS04225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sa5Y_RS04230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sa5Y_RS04240	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Sa5Y_RS04245	COG1138	Cytochrome C-type biogenesis protein
Sa5Y_RS04250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sa5Y_RS04255	COG3088	subunit of a heme lyase
Sa5Y_RS04255	COG4235	cytochrome complex assembly
Sa5Y_RS04265	COG2853	Lipoprotein
Sa5Y_RS04285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Sa5Y_RS04290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sa5Y_RS04295	COG0123	including yeast histone deacetylase and acetoin utilization protein
Sa5Y_RS04310	COG3083	sulfuric ester hydrolase activity
Sa5Y_RS04315	COG3082	Protein of unknown function (DUF1414)
Sa5Y_RS04320	COG3081	Nucleoid-associated protein
Sa5Y_RS04330	COG1757	Na H antiporter
Sa5Y_RS04335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sa5Y_RS04340	COG2095	MarC family integral membrane protein
Sa5Y_RS04345	COG1012	belongs to the aldehyde dehydrogenase family
Sa5Y_RS04345	COG1454	alcohol dehydrogenase
Sa5Y_RS04360	COG0659	secondary active sulfate transmembrane transporter activity
Sa5Y_RS04365	COG1530	ribonuclease E activity
Sa5Y_RS04380	COG0564	pseudouridine synthase activity
Sa5Y_RS04385	COG0424	maF-like protein
Sa5Y_RS04390	COG1399	metal-binding, possibly nucleic acid-binding protein
Sa5Y_RS04395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Sa5Y_RS04400	COG0416	fatty acid biosynthetic process
Sa5Y_RS04405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sa5Y_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
Sa5Y_RS04420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Sa5Y_RS04425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sa5Y_RS04430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sa5Y_RS04435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Sa5Y_RS04440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Sa5Y_RS04450	COG0084	hydrolase, TatD family'
Sa5Y_RS04455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa5Y_RS04455	COG1263	PTS System
Sa5Y_RS04465	COG0733	neurotransmitter:sodium symporter activity
Sa5Y_RS04480	COG4667	esterase of the alpha-beta hydrolase superfamily
Sa5Y_RS04490	COG1940	carbohydrate kinase activity
Sa5Y_RS04495	COG0784	Response regulator, receiver
Sa5Y_RS04495	COG0835	chemotaxis
Sa5Y_RS04510	COG2226	methyltransferase
Sa5Y_RS04525	COG0676	glucose-6-phosphate 1-epimerase activity
Sa5Y_RS04530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Sa5Y_RS04535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa5Y_RS04545	COG3139	Protein of unknown function (DUF1315)
Sa5Y_RS04550	COG0252	asparaginase activity
Sa5Y_RS04555	COG0616	signal peptide processing
Sa5Y_RS04560	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa5Y_RS04560	COG1902	pentaerythritol trinitrate reductase activity
Sa5Y_RS04565	COG0788	formyltetrahydrofolate deformylase activity
Sa5Y_RS04580	COG1199	ATP-dependent helicase activity
Sa5Y_RS04585	COG1214	PFAM Peptidase M22, glycoprotease
Sa5Y_RS04600	COG0596	Alpha beta hydrolase
Sa5Y_RS04605	COG0318	PFAM AMP-dependent synthetase and ligase
Sa5Y_RS04610	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Sa5Y_RS04615	COG0705	Rhomboid family
Sa5Y_RS04625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Sa5Y_RS04630	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Sa5Y_RS04635	COG0436	Aminotransferase
Sa5Y_RS04640	COG1169	isochorismate synthase
Sa5Y_RS04645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Sa5Y_RS04650	COG0596	Alpha beta hydrolase
Sa5Y_RS04670	COG3135	benzoate transporter
Sa5Y_RS04695	COG3015	lipoprotein NlpE involved in copper resistance
Sa5Y_RS04700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Sa5Y_RS04705	COG2894	cell division
Sa5Y_RS04710	COG0850	regulation of cytokinetic process
Sa5Y_RS04715	COG3100	YcgL domain-containing protein
Sa5Y_RS04720	COG2951	lytic endotransglycosylase activity
Sa5Y_RS04730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Sa5Y_RS04740	COG3005	denitrification pathway
Sa5Y_RS04745	COG0243	molybdopterin cofactor binding
Sa5Y_RS04760	COG0583	DNA-binding transcription factor activity
Sa5Y_RS04765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa5Y_RS04775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Sa5Y_RS04815	COG4589	Belongs to the CDS family
Sa5Y_RS04825	COG5001	Diguanylate cyclase
Sa5Y_RS04825	COG3300	MHYT domain
Sa5Y_RS04840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Sa5Y_RS04845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa5Y_RS04850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Sa5Y_RS04855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa5Y_RS04865	COG4191	Histidine kinase
Sa5Y_RS04875	COG0544	peptidyl-prolyl cis-trans isomerase activity
Sa5Y_RS04885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Sa5Y_RS04890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Sa5Y_RS04895	COG0776	regulation of translation
Sa5Y_RS04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sa5Y_RS04905	COG1555	photosystem II stabilization
Sa5Y_RS04910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Sa5Y_RS04915	COG0539	negative regulation of cytoplasmic translation
Sa5Y_RS04920	COG0776	regulation of translation
Sa5Y_RS04925	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Sa5Y_RS04930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Sa5Y_RS04940	COG0601	transmembrane transport
Sa5Y_RS04945	COG4239	(ABC) transporter, permease
Sa5Y_RS04950	COG0747	negative chemotaxis
Sa5Y_RS04955	COG0444	Belongs to the ABC transporter superfamily
Sa5Y_RS04960	COG4608	Belongs to the ABC transporter superfamily
Sa5Y_RS04985	COG0583	DNA-binding transcription factor activity
Sa5Y_RS04995	COG0686	Belongs to the AlaDH PNT family
Sa5Y_RS05005	COG1674	ftsk spoiiie
Sa5Y_RS05010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Sa5Y_RS05015	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Sa5Y_RS05020	COG2186	Transcriptional regulator
Sa5Y_RS05035	COG0537	adenosine 5'-monophosphoramidase activity
Sa5Y_RS05060	COG3150	esterase
Sa5Y_RS05065	COG1252	NADH dehydrogenase
Sa5Y_RS05085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Sa5Y_RS05095	COG4591	ABC-type transport system involved in lipoprotein release permease component
Sa5Y_RS05100	COG1136	(ABC) transporter
Sa5Y_RS05105	COG4591	ABC-type transport system involved in lipoprotein release permease component
Sa5Y_RS05115	COG0658	competence protein
Sa5Y_RS05115	COG2333	competence protein COMEC
Sa5Y_RS05120	COG1132	(ABC) transporter
Sa5Y_RS05125	COG1663	tetraacyldisaccharide 4'-kinase activity
Sa5Y_RS05130	COG2835	tetraacyldisaccharide 4'-kinase activity
Sa5Y_RS05135	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Sa5Y_RS05140	COG2719	SpoVR family
Sa5Y_RS05145	COG2718	Belongs to the UPF0229 family
Sa5Y_RS05150	COG2766	serine protein kinase
Sa5Y_RS05155	COG3013	Belongs to the UPF0304 family
Sa5Y_RS05165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Sa5Y_RS05170	COG0840	transmembrane signaling receptor activity
Sa5Y_RS05180	COG1882	Formate acetyltransferase
Sa5Y_RS05205	COG4160	amino acid transport
Sa5Y_RS05210	COG0708	Exodeoxyribonuclease III
Sa5Y_RS05215	COG0840	transmembrane signaling receptor activity
Sa5Y_RS05225	COG3923	Primosomal replication protein n
Sa5Y_RS05230	COG0730	response to heat
Sa5Y_RS05235	COG1199	ATP-dependent helicase activity
Sa5Y_RS05240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Sa5Y_RS05245	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Sa5Y_RS05250	COG3012	SEC-C Motif Domain Protein
Sa5Y_RS05255	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Sa5Y_RS05260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa5Y_RS05265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Sa5Y_RS05270	COG0215	cysteine-tRNA ligase activity
Sa5Y_RS05275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Sa5Y_RS05280	COG0632	four-way junction helicase activity
Sa5Y_RS05290	COG1271	oxidase subunit
Sa5Y_RS05295	COG1294	oxidase, subunit
Sa5Y_RS05300	COG4890	Cyd operon protein YbgT
Sa5Y_RS05305	COG3790	cyd operon protein YbgE
Sa5Y_RS05310	COG0824	Thioesterase
Sa5Y_RS05315	COG0811	peptide transport
Sa5Y_RS05330	COG0823	Involved in the tonB-independent uptake of proteins
Sa5Y_RS05335	COG2885	chlorophyll binding
Sa5Y_RS05345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Sa5Y_RS05355	COG5002	protein histidine kinase activity
Sa5Y_RS05355	COG0784	Response regulator, receiver
Sa5Y_RS05365	COG1012	belongs to the aldehyde dehydrogenase family
Sa5Y_RS05370	COG3284	Transcriptional regulator
Sa5Y_RS05375	COG4628	conserved protein (DUF2132)
Sa5Y_RS05385	COG0415	Belongs to the DNA photolyase family
Sa5Y_RS05415	COG4409	exo-alpha-(2->6)-sialidase activity
Sa5Y_RS05420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Sa5Y_RS05425	COG1940	carbohydrate kinase activity
Sa5Y_RS05440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa5Y_RS05445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Sa5Y_RS05450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa5Y_RS05455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sa5Y_RS05460	COG1737	Transcriptional regulator
Sa5Y_RS05465	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Sa5Y_RS05470	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Sa5Y_RS05480	COG4932	domain protein
Sa5Y_RS05480	COG5492	domain, Protein
Sa5Y_RS05505	COG0596	Alpha beta hydrolase
Sa5Y_RS05515	COG3064	Membrane
Sa5Y_RS05630	COG4789	Type iii secretion
Sa5Y_RS05635	COG4792	protein secretion
Sa5Y_RS05665	COG3710	Transcriptional regulator
Sa5Y_RS05675	COG4790	Type iii secretion
Sa5Y_RS05755	COG0582	viral genome integration into host DNA
Sa5Y_RS05770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa5Y_RS05780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Sa5Y_RS05780	COG3008	intermembrane lipid transfer
Sa5Y_RS05785	COG2995	paraquat-inducible protein a
Sa5Y_RS05790	COG0668	transmembrane transport
Sa5Y_RS05810	COG1309	transcriptional regulator
Sa5Y_RS05815	COG1012	belongs to the aldehyde dehydrogenase family
Sa5Y_RS05835	COG1960	acyl-CoA dehydrogenase activity
Sa5Y_RS05840	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Sa5Y_RS05850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Sa5Y_RS05855	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Sa5Y_RS05860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Sa5Y_RS05880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sa5Y_RS05885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Sa5Y_RS05890	COG0297	glycogen (starch) synthase activity
Sa5Y_RS05910	COG3070	regulator of competence-specific genes
Sa5Y_RS05915	COG1609	Transcriptional regulator
Sa5Y_RS05930	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS05935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Sa5Y_RS05940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sa5Y_RS05945	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
Sa5Y_RS05950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Sa5Y_RS05955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Sa5Y_RS05960	COG1979	alcohol dehydrogenase
Sa5Y_RS05965	COG2207	Transcriptional regulator
Sa5Y_RS05990	COG1032	radical SAM domain protein
Sa5Y_RS05995	COG5001	Diguanylate cyclase
Sa5Y_RS06000	COG0612	Peptidase, M16
Sa5Y_RS06015	COG0583	DNA-binding transcription factor activity
Sa5Y_RS06020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Sa5Y_RS06030	COG2350	Protein conserved in bacteria
Sa5Y_RS06035	COG1607	acyl-coa hydrolase
Sa5Y_RS06050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Sa5Y_RS06055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa5Y_RS06070	COG2116	formate transmembrane transporter activity
Sa5Y_RS06080	COG4459	periplasmic nitrate reductase
Sa5Y_RS06085	COG3005	denitrification pathway
Sa5Y_RS06090	COG0243	molybdopterin cofactor binding
Sa5Y_RS06105	COG1227	inorganic diphosphatase activity
Sa5Y_RS06120	COG4172	Belongs to the ABC transporter superfamily
Sa5Y_RS06135	COG4168	peptide transport system, permease
Sa5Y_RS06145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Sa5Y_RS06150	COG1842	Phage shock protein A
Sa5Y_RS06165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa5Y_RS06180	COG2818	Glycosylase
Sa5Y_RS06185	COG0626	cystathionine gamma-synthase activity
Sa5Y_RS06195	COG0733	neurotransmitter:sodium symporter activity
Sa5Y_RS06200	COG0564	pseudouridine synthase activity
Sa5Y_RS06205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sa5Y_RS06210	COG4136	ATPase activity
Sa5Y_RS06215	COG4135	transport system, permease component
Sa5Y_RS06220	COG4134	Bacterial extracellular solute-binding protein
Sa5Y_RS06230	COG3313	Fe-S protein
Sa5Y_RS06240	COG0842	Transport permease protein
Sa5Y_RS06245	COG1131	(ABC) transporter
Sa5Y_RS06250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa5Y_RS06255	COG0814	amino acid
Sa5Y_RS06265	COG2239	Acts as a magnesium transporter
Sa5Y_RS06270	COG0784	Response regulator, receiver
Sa5Y_RS06270	COG2205	protein histidine kinase activity
Sa5Y_RS06285	COG4934	collagen metabolic process
Sa5Y_RS06315	COG0840	transmembrane signaling receptor activity
Sa5Y_RS06330	COG3706	GGDEF domain
Sa5Y_RS06330	COG4251	negative regulation of phosphorylation
Sa5Y_RS06330	COG5001	Diguanylate cyclase
Sa5Y_RS06330	COG2203	Gaf domain
Sa5Y_RS06335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Sa5Y_RS06355	COG1061	Type III restriction enzyme res subunit
Sa5Y_RS06360	COG1187	pseudouridine synthase activity
Sa5Y_RS06365	COG2814	Major facilitator Superfamily
Sa5Y_RS06375	COG0702	epimerase
Sa5Y_RS06380	COG0534	Mate efflux family protein
Sa5Y_RS06385	COG4181	ATPase activity
Sa5Y_RS06390	COG0577	efflux transmembrane transporter activity
Sa5Y_RS06400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Sa5Y_RS06415	COG1748	Saccharopine dehydrogenase
Sa5Y_RS06430	COG1538	Outer membrane efflux protein
Sa5Y_RS06500	COG0583	DNA-binding transcription factor activity
Sa5Y_RS06510	COG1451	nucleotide metabolic process
Sa5Y_RS06525	COG3063	Type IV pilus biogenesis stability protein PilW
Sa5Y_RS06530	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Sa5Y_RS06550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa5Y_RS06565	COG3290	protein histidine kinase activity
Sa5Y_RS06570	COG4565	transcriptional regulatory protein
Sa5Y_RS06580	COG0835	chemotaxis
Sa5Y_RS06580	COG0784	Response regulator, receiver
Sa5Y_RS06625	COG1085	galactose-1-phosphate uridylyltransferase
Sa5Y_RS06630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Sa5Y_RS06635	COG2017	converts alpha-aldose to the beta-anomer
Sa5Y_RS06645	COG2199	diguanylate cyclase activity
Sa5Y_RS06645	COG2200	EAL domain
Sa5Y_RS06660	COG3527	Alpha-acetolactate decarboxylase
Sa5Y_RS06675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Sa5Y_RS06685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Sa5Y_RS06700	COG3097	Belongs to the UPF0267 family
Sa5Y_RS06725	COG1271	oxidase subunit
Sa5Y_RS06730	COG1294	oxidase, subunit
Sa5Y_RS06735	COG1136	(ABC) transporter
Sa5Y_RS06735	COG4591	ABC-type transport system involved in lipoprotein release permease component
Sa5Y_RS06740	COG1136	(ABC) transporter
Sa5Y_RS06740	COG0577	efflux transmembrane transporter activity
Sa5Y_RS06745	COG0577	efflux transmembrane transporter activity
Sa5Y_RS06745	COG1136	(ABC) transporter
Sa5Y_RS06770	COG2723	6-phospho-beta-galactosidase activity
Sa5Y_RS06775	COG1609	Transcriptional regulator
Sa5Y_RS06780	COG0251	oxidation-reduction process
Sa5Y_RS06785	COG2731	YhcH YjgK YiaL family protein
Sa5Y_RS06790	COG0584	glycerophosphoryl diester phosphodiesterase
Sa5Y_RS06795	COG1349	DNA-binding transcription factor activity
Sa5Y_RS06800	COG3842	ATPase activity
Sa5Y_RS06805	COG0395	ABC-type sugar transport system, permease component
Sa5Y_RS06810	COG1175	transmembrane transport
Sa5Y_RS06825	COG0811	peptide transport
Sa5Y_RS06830	COG0811	peptide transport
Sa5Y_RS06835	COG0848	biopolymer transport protein
Sa5Y_RS06840	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Sa5Y_RS06850	COG1793	dna ligase
Sa5Y_RS06860	COG0534	Mate efflux family protein
Sa5Y_RS06870	COG3001	Fructosamine kinase
Sa5Y_RS06880	COG0791	NLP P60 protein
Sa5Y_RS06885	COG3290	protein histidine kinase activity
Sa5Y_RS06885	COG0840	transmembrane signaling receptor activity
Sa5Y_RS06895	COG3148	PFAM DTW domain containing protein
Sa5Y_RS06900	COG1940	carbohydrate kinase activity
Sa5Y_RS06915	COG0303	'Molybdopterin
Sa5Y_RS06920	COG0746	molybdenum cofactor guanylyltransferase activity
Sa5Y_RS06925	COG3842	ATPase activity
Sa5Y_RS06930	COG4662	Binding-protein-dependent transport system inner membrane component
Sa5Y_RS06940	COG2204	response regulator
Sa5Y_RS06945	COG3852	Histidine kinase
Sa5Y_RS06950	COG0488	(ABC) transporter
Sa5Y_RS06955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Sa5Y_RS06985	COG0243	molybdopterin cofactor binding
Sa5Y_RS06985	COG3383	formate dehydrogenase (NAD+) activity
Sa5Y_RS06990	COG0437	4 iron, 4 sulfur cluster binding
Sa5Y_RS07005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Sa5Y_RS07010	COG1666	GTP binding
Sa5Y_RS07015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Sa5Y_RS07030	COG2996	Protein conserved in bacteria
Sa5Y_RS07040	COG3008	intermembrane lipid transfer
Sa5Y_RS07045	COG2995	paraquat-inducible protein a
Sa5Y_RS07050	COG1132	(ABC) transporter
Sa5Y_RS07055	COG1956	GAF domain-containing protein
Sa5Y_RS07060	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Sa5Y_RS07075	COG0308	aminopeptidase N
Sa5Y_RS07090	COG0167	dihydroorotate dehydrogenase activity
Sa5Y_RS07100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Sa5Y_RS07100	COG0116	Belongs to the methyltransferase superfamily
Sa5Y_RS07110	COG0488	(ABC) transporter
Sa5Y_RS07125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sa5Y_RS07130	COG1067	ATP-dependent peptidase activity
Sa5Y_RS07135	COG3120	sequence-specific DNA binding
Sa5Y_RS07225	COG3064	Membrane
Sa5Y_RS07225	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Sa5Y_RS07225	COG1073	alpha beta
Sa5Y_RS07230	COG2994	toxin metabolic process
Sa5Y_RS07255	COG0784	Response regulator, receiver
Sa5Y_RS07255	COG2205	protein histidine kinase activity
Sa5Y_RS07270	COG3278	Belongs to the heme-copper respiratory oxidase family
Sa5Y_RS07285	COG2010	Cytochrome c
Sa5Y_RS07295	COG2217	Heavy metal translocating P-type atpase
Sa5Y_RS07310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Sa5Y_RS07315	COG0589	response to stress
Sa5Y_RS07320	COG0037	tRNA processing
Sa5Y_RS07340	COG3842	ATPase activity
Sa5Y_RS07350	COG1177	transmembrane transport
Sa5Y_RS07360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Sa5Y_RS07375	COG1115	amino acid carrier protein
Sa5Y_RS07380	COG1280	lysine exporter protein (LysE YggA)
Sa5Y_RS07420	COG3501	Rhs element vgr protein
Sa5Y_RS07430	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Sa5Y_RS07435	COG0840	transmembrane signaling receptor activity
Sa5Y_RS07440	COG2814	Major facilitator Superfamily
Sa5Y_RS07445	COG1566	PFAM secretion protein HlyD family protein
Sa5Y_RS07450	COG1538	Outer membrane efflux protein
Sa5Y_RS07460	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS07470	COG0840	transmembrane signaling receptor activity
Sa5Y_RS07475	COG0840	transmembrane signaling receptor activity
Sa5Y_RS07480	COG0835	chemotaxis
Sa5Y_RS07485	COG2201	protein-glutamate methylesterase activity
Sa5Y_RS07495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Sa5Y_RS07500	COG0784	Response regulator, receiver
Sa5Y_RS07500	COG2198	Histidine kinase
Sa5Y_RS07500	COG0643	Histidine kinase
Sa5Y_RS07505	COG2198	Histidine kinase
Sa5Y_RS07505	COG0643	Histidine kinase
Sa5Y_RS07515	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS07530	COG0415	Belongs to the DNA photolyase family
Sa5Y_RS07535	COG0477	Major facilitator Superfamily
Sa5Y_RS07540	COG0583	DNA-binding transcription factor activity
Sa5Y_RS07550	COG0095	Lipoate-protein ligase
Sa5Y_RS07555	COG0443	Heat shock 70 kDa protein
Sa5Y_RS07565	COG1643	Atp-dependent helicase
Sa5Y_RS07605	COG0443	Heat shock 70 kDa protein
Sa5Y_RS07610	COG0443	Heat shock 70 kDa protein
Sa5Y_RS07615	COG3706	GGDEF domain
Sa5Y_RS07645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Sa5Y_RS07650	COG0602	queuosine metabolic process
Sa5Y_RS07660	COG0561	phosphatase activity
Sa5Y_RS07670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa5Y_RS07675	COG4597	amino acid ABC transporter
Sa5Y_RS07680	COG0765	amino acid transport
Sa5Y_RS07685	COG1126	abc transporter atp-binding protein
Sa5Y_RS07690	COG0670	Belongs to the BI1 family
Sa5Y_RS07695	COG2920	part of a sulfur-relay system
Sa5Y_RS07700	COG1254	Belongs to the acylphosphatase family
Sa5Y_RS07705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Sa5Y_RS07710	COG3706	GGDEF domain
Sa5Y_RS07730	COG3437	response regulator, receiver
Sa5Y_RS07735	COG0625	glutathione transferase activity
Sa5Y_RS07745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Sa5Y_RS07755	COG2195	Cleaves the N-terminal amino acid of tripeptides
Sa5Y_RS07785	COG0372	Belongs to the citrate synthase family
Sa5Y_RS07790	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Sa5Y_RS07815	COG0583	DNA-binding transcription factor activity
Sa5Y_RS07820	COG4771	TonB-dependent receptor
Sa5Y_RS07845	COG1566	PFAM secretion protein HlyD family protein
Sa5Y_RS07865	COG1129	ABC transporter
Sa5Y_RS07895	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS07900	COG5002	protein histidine kinase activity
Sa5Y_RS07905	COG3713	MltA-interacting MipA family protein
Sa5Y_RS07910	COG2990	Protein conserved in bacteria
Sa5Y_RS07920	COG4191	Histidine kinase
Sa5Y_RS07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa5Y_RS07925	COG0471	metal ion transport
Sa5Y_RS07935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Sa5Y_RS07955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS07965	COG3768	UPF0283 membrane protein
Sa5Y_RS07970	COG3106	COG3106 Predicted ATPase
Sa5Y_RS07985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sa5Y_RS07990	COG0494	nUDIX hydrolase
Sa5Y_RS07995	COG0814	amino acid
Sa5Y_RS08000	COG1760	l-serine dehydratase
Sa5Y_RS08005	COG0720	synthase
Sa5Y_RS08015	COG0017	Asparaginyl-tRNA synthetase
Sa5Y_RS08020	COG0351	phosphomethylpyrimidine kinase
Sa5Y_RS08025	COG2770	Histidine kinase
Sa5Y_RS08025	COG3437	response regulator, receiver
Sa5Y_RS08035	COG1448	Aminotransferase
Sa5Y_RS08050	COG0840	transmembrane signaling receptor activity
Sa5Y_RS08055	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Sa5Y_RS08060	COG2943	transferase activity, transferring hexosyl groups
Sa5Y_RS08065	COG1609	Transcriptional regulator
Sa5Y_RS08070	COG3394	polysaccharide catabolic process
Sa5Y_RS08075	COG1486	melibiose metabolic process
Sa5Y_RS08080	COG1447	Phosphotransferase system cellobiose-specific component IIA
Sa5Y_RS08090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Sa5Y_RS08095	COG0726	polysaccharide deacetylase
Sa5Y_RS08100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Sa5Y_RS08105	COG1846	Transcriptional regulator
Sa5Y_RS08135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa5Y_RS08150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa5Y_RS08155	COG3108	Peptidase M15
Sa5Y_RS08185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sa5Y_RS08195	COG2814	Major facilitator Superfamily
Sa5Y_RS08205	COG1054	Belongs to the UPF0176 family
Sa5Y_RS08215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sa5Y_RS08220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Sa5Y_RS08225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Sa5Y_RS08275	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Sa5Y_RS08280	COG4139	cobalamin transport
Sa5Y_RS08285	COG2988	succinylglutamate desuccinylase activity
Sa5Y_RS08300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Sa5Y_RS08305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Sa5Y_RS08310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa5Y_RS08315	COG1823	symporter activity
Sa5Y_RS08320	COG2925	Exonuclease
Sa5Y_RS08325	COG1380	Effector of murein hydrolase LrgA
Sa5Y_RS08330	COG1346	cytolysis
Sa5Y_RS08375	COG0776	regulation of translation
Sa5Y_RS08380	COG0072	phenylalanine-tRNA ligase activity
Sa5Y_RS08380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa5Y_RS08385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Sa5Y_RS08425	COG0322	excinuclease ABC activity
Sa5Y_RS08430	COG2197	response regulator
Sa5Y_RS08435	COG0417	DNA replication proofreading
Sa5Y_RS08440	COG5001	Diguanylate cyclase
Sa5Y_RS08450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Sa5Y_RS08455	COG3099	Belongs to the UPF0263 family
Sa5Y_RS08470	COG1228	amidohydrolase
Sa5Y_RS08475	COG0010	Belongs to the arginase family
Sa5Y_RS08480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Sa5Y_RS08485	COG2986	histidine ammonia-lyase
Sa5Y_RS08505	COG0247	lactate metabolic process
Sa5Y_RS08505	COG0277	FAD linked oxidase domain protein
Sa5Y_RS08520	COG2885	chlorophyll binding
Sa5Y_RS08540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Sa5Y_RS08550	COG0281	malic enzyme
Sa5Y_RS08560	COG2949	membrane
Sa5Y_RS08565	COG3706	GGDEF domain
Sa5Y_RS08570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sa5Y_RS08580	COG0492	ferredoxin-NADP+ reductase activity
Sa5Y_RS08585	COG4988	ABC transporter
Sa5Y_RS08590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Sa5Y_RS08595	COG1187	pseudouridine synthase activity
Sa5Y_RS08600	COG0009	L-threonylcarbamoyladenylate synthase
Sa5Y_RS08605	COG0613	PHP domain protein
Sa5Y_RS08615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sa5Y_RS08620	COG0512	Glutamine amidotransferase of anthranilate synthase
Sa5Y_RS08625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Sa5Y_RS08630	COG0134	indole-3-glycerol-phosphate synthase activity
Sa5Y_RS08630	COG0135	phosphoribosylanthranilate isomerase activity
Sa5Y_RS08635	COG0133	tryptophan synthase activity
Sa5Y_RS08640	COG0159	tryptophan synthase activity
Sa5Y_RS08650	COG1435	thymidine kinase activity
Sa5Y_RS08655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Sa5Y_RS08660	COG1801	Protein of unknown function DUF72
Sa5Y_RS08665	COG4106	trans-aconitate 2-methyltransferase activity
Sa5Y_RS08670	COG0500	methyltransferase
Sa5Y_RS08675	COG4067	protein conserved in archaea
Sa5Y_RS08675	COG0189	ligase activity
Sa5Y_RS08690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Sa5Y_RS08700	COG3852	Histidine kinase
Sa5Y_RS08715	COG3070	regulator of competence-specific genes
Sa5Y_RS08725	COG2431	L-lysine efflux transmembrane transporter activity
Sa5Y_RS08735	COG0076	glutamate decarboxylase activity
Sa5Y_RS08740	COG1737	Transcriptional regulator
Sa5Y_RS08745	COG1454	alcohol dehydrogenase
Sa5Y_RS08745	COG1012	belongs to the aldehyde dehydrogenase family
Sa5Y_RS08750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Sa5Y_RS08755	COG3273	potassium ion transport
Sa5Y_RS08755	COG2985	domain, Protein
Sa5Y_RS08760	COG0542	response to heat
Sa5Y_RS08765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Sa5Y_RS08770	COG1278	Cold shock
Sa5Y_RS08780	COG1187	pseudouridine synthase activity
Sa5Y_RS08785	COG0140	phosphoribosyl-ATP diphosphatase activity
Sa5Y_RS08785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Sa5Y_RS08790	COG0107	imidazoleglycerol-phosphate synthase activity
Sa5Y_RS08795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Sa5Y_RS08800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Sa5Y_RS08805	COG0131	Imidazoleglycerol-phosphate dehydratase
Sa5Y_RS08805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Sa5Y_RS08810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sa5Y_RS08815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sa5Y_RS08820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Sa5Y_RS08825	COG1757	Na H antiporter
Sa5Y_RS08830	COG2916	Histone family protein nucleoid-structuring protein H-NS
Sa5Y_RS08835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa5Y_RS08840	COG0482	sulfurtransferase activity
Sa5Y_RS08845	COG2915	High frequency lysogenization protein hflD homolog
Sa5Y_RS08850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Sa5Y_RS08860	COG2268	Band 7 protein
Sa5Y_RS08870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa5Y_RS08885	COG0300	oxidoreductase activity
Sa5Y_RS08895	COG0501	Belongs to the peptidase M48B family
Sa5Y_RS08905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Sa5Y_RS08910	COG2226	methyltransferase
Sa5Y_RS08915	COG0156	8-amino-7-oxononanoate synthase activity
Sa5Y_RS08920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Sa5Y_RS08925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Sa5Y_RS08930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Sa5Y_RS08935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Sa5Y_RS08940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Sa5Y_RS08945	COG0653	protein targeting
Sa5Y_RS08950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Sa5Y_RS08955	COG2203	Gaf domain
Sa5Y_RS08955	COG2199	diguanylate cyclase activity
Sa5Y_RS08965	COG4120	Belongs to the binding-protein-dependent transport system permease family
Sa5Y_RS08975	COG4628	conserved protein (DUF2132)
Sa5Y_RS08980	COG3092	negative regulation of chromosome organization
Sa5Y_RS08985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Sa5Y_RS08990	COG0280	phosphate acetyltransferase
Sa5Y_RS08990	COG0857	belongs to the CobB CobQ family
Sa5Y_RS08995	COG0435	Glutathione S-transferase
Sa5Y_RS09000	COG4608	Belongs to the ABC transporter superfamily
Sa5Y_RS09005	COG0444	Belongs to the ABC transporter superfamily
Sa5Y_RS09010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa5Y_RS09015	COG0601	transmembrane transport
Sa5Y_RS09035	COG2204	response regulator
Sa5Y_RS09040	COG5001	Diguanylate cyclase
Sa5Y_RS09040	COG3300	MHYT domain
Sa5Y_RS09045	COG4191	Histidine kinase
Sa5Y_RS09050	COG5002	protein histidine kinase activity
Sa5Y_RS09060	COG2201	protein-glutamate methylesterase activity
Sa5Y_RS09075	COG0009	L-threonylcarbamoyladenylate synthase
Sa5Y_RS09095	COG1881	PFAM PEBP family protein
Sa5Y_RS09120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa5Y_RS09125	COG3716	PTS system mannose fructose sorbose family IID component
Sa5Y_RS09135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa5Y_RS09140	COG2222	sugar isomerase
Sa5Y_RS09150	COG1349	DNA-binding transcription factor activity
Sa5Y_RS09155	COG1349	DNA-binding transcription factor activity
Sa5Y_RS09170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Sa5Y_RS09175	COG0640	Transcriptional regulator
Sa5Y_RS09185	COG3706	GGDEF domain
Sa5Y_RS09205	COG1946	Acyl-CoA thioesterase
Sa5Y_RS09210	COG1522	sequence-specific DNA binding
Sa5Y_RS09220	COG0616	signal peptide processing
Sa5Y_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
Sa5Y_RS09230	COG2983	Belongs to the UPF0260 family
Sa5Y_RS09240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Sa5Y_RS09245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Sa5Y_RS09255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Sa5Y_RS09260	COG2832	Protein of unknown function (DUF454)
Sa5Y_RS09270	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS09275	COG0583	DNA-binding transcription factor activity
Sa5Y_RS09280	COG0778	Nitroreductase
Sa5Y_RS09285	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa5Y_RS09285	COG1024	Enoyl-CoA hydratase
Sa5Y_RS09290	COG0183	Belongs to the thiolase family
Sa5Y_RS09310	COG2067	long-chain fatty acid transport protein
Sa5Y_RS09320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Sa5Y_RS09325	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Sa5Y_RS09330	COG2982	Protein involved in outer membrane biogenesis
Sa5Y_RS09335	COG0572	uridine kinase
Sa5Y_RS09345	COG0489	protein tyrosine kinase activity
Sa5Y_RS09350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa5Y_RS09350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa5Y_RS09365	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Sa5Y_RS09380	COG0517	IMP dehydrogenase activity
Sa5Y_RS09380	COG0617	tRNA 3'-terminal CCA addition
Sa5Y_RS09380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Sa5Y_RS09385	COG2199	diguanylate cyclase activity
Sa5Y_RS09390	COG0314	molybdopterin synthase activity
Sa5Y_RS09395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Sa5Y_RS09400	COG0315	cyclic pyranopterin monophosphate synthase activity
Sa5Y_RS09405	COG0521	Mo-molybdopterin cofactor biosynthetic process
Sa5Y_RS09410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sa5Y_RS09415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Sa5Y_RS09420	COG2198	Histidine kinase
Sa5Y_RS09425	COG2204	response regulator
Sa5Y_RS09435	COG0556	nucleotide-excision repair
Sa5Y_RS09445	COG4657	Part of a membrane complex involved in electron transport
Sa5Y_RS09450	COG2878	Part of a membrane complex involved in electron transport
Sa5Y_RS09455	COG4656	Part of a membrane complex involved in electron transport
Sa5Y_RS09470	COG4660	Part of a membrane complex involved in electron transport
Sa5Y_RS09475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sa5Y_RS09480	COG0346	lactoylglutathione lyase activity
Sa5Y_RS09495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Sa5Y_RS09500	COG2056	Na+-H+ antiporter family
Sa5Y_RS09505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sa5Y_RS09510	COG1286	toxin biosynthetic process
Sa5Y_RS09515	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Sa5Y_RS09520	COG0285	dihydrofolate synthase activity
Sa5Y_RS09525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Sa5Y_RS09530	COG0101	tRNA pseudouridine synthase activity
Sa5Y_RS09545	COG1263	PTS System
Sa5Y_RS09545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa5Y_RS09545	COG2190	(PTS) system
Sa5Y_RS09550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Sa5Y_RS09555	COG1940	carbohydrate kinase activity
Sa5Y_RS09555	COG1846	Transcriptional regulator
Sa5Y_RS09560	COG4651	solute:proton antiporter activity
Sa5Y_RS09560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sa5Y_RS09565	COG0367	asparagine synthase
Sa5Y_RS09575	COG3104	oligopeptide transport
Sa5Y_RS09580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Sa5Y_RS09585	COG0563	adenylate kinase activity
Sa5Y_RS09590	COG0326	Molecular chaperone. Has ATPase activity
Sa5Y_RS09595	COG3710	Transcriptional regulator
Sa5Y_RS09610	COG0622	Phosphoesterase
Sa5Y_RS09615	COG1090	epimerase
Sa5Y_RS09620	COG0300	oxidoreductase activity
Sa5Y_RS09630	COG3118	belongs to the thioredoxin family
Sa5Y_RS09635	COG0330	HflC and HflK could
Sa5Y_RS09640	COG1585	Membrane protein implicated in regulation of membrane protease activity
Sa5Y_RS09645	COG0789	Transcriptional regulator
Sa5Y_RS09650	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Sa5Y_RS09660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Sa5Y_RS09665	COG3115	cell septum assembly
Sa5Y_RS09670	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Sa5Y_RS09675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Sa5Y_RS09685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa5Y_RS09695	COG2190	(PTS) system
Sa5Y_RS09700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa5Y_RS09705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sa5Y_RS09710	COG1702	phosphate starvation-inducible protein PhoH
Sa5Y_RS09715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Sa5Y_RS09720	COG4535	Mg2 and Co2 transporter CorC
Sa5Y_RS09725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Sa5Y_RS09735	COG0495	leucyl-tRNA aminoacylation
Sa5Y_RS09740	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Sa5Y_RS09745	COG1466	dna polymerase III delta subunit
Sa5Y_RS09750	COG0799	negative regulation of ribosome biogenesis
Sa5Y_RS09755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Sa5Y_RS09760	COG0768	penicillin binding
Sa5Y_RS09765	COG0772	Belongs to the SEDS family
Sa5Y_RS09770	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Sa5Y_RS09775	COG1686	Belongs to the peptidase S11 family
Sa5Y_RS09780	COG2921	Belongs to the UPF0250 family
Sa5Y_RS09785	COG0321	lipoyl(octanoyl) transferase activity
Sa5Y_RS09790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Sa5Y_RS09800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Sa5Y_RS09825	COG1596	polysaccharide export
Sa5Y_RS09835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sa5Y_RS09865	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Sa5Y_RS09875	COG0438	transferase activity, transferring glycosyl groups
Sa5Y_RS09885	COG0438	transferase activity, transferring glycosyl groups
Sa5Y_RS09915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Sa5Y_RS09920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Sa5Y_RS09925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Sa5Y_RS09930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sa5Y_RS09960	COG0366	Alpha amylase catalytic
Sa5Y_RS09965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa5Y_RS09965	COG1263	PTS System
Sa5Y_RS09970	COG1609	Transcriptional regulator
Sa5Y_RS09975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Sa5Y_RS09980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Sa5Y_RS09985	COG2011	ABC-type metal ion transport system permease component
Sa5Y_RS09990	COG1464	Belongs to the NlpA lipoprotein family
Sa5Y_RS09995	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
Sa5Y_RS10005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Sa5Y_RS10005	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Sa5Y_RS10020	COG1611	Belongs to the LOG family
Sa5Y_RS10025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sa5Y_RS10030	COG2363	Small membrane protein
Sa5Y_RS10035	COG0583	DNA-binding transcription factor activity
Sa5Y_RS10040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Sa5Y_RS10040	COG0301	tRNA thio-modification
Sa5Y_RS10050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Sa5Y_RS10055	COG1722	exodeoxyribonuclease VII activity
Sa5Y_RS10060	COG0142	geranyltranstransferase activity
Sa5Y_RS10065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sa5Y_RS10070	COG0564	pseudouridine synthase activity
Sa5Y_RS10075	COG3098	single-species biofilm formation
Sa5Y_RS10090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS10100	COG1671	Belongs to the UPF0178 family
Sa5Y_RS10105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Sa5Y_RS10110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Sa5Y_RS10115	COG0254	rRNA binding
Sa5Y_RS10120	COG1720	tRNA m6t6A37 methyltransferase activity
Sa5Y_RS10125	COG0442	prolyl-tRNA aminoacylation
Sa5Y_RS10145	COG0047	phosphoribosylformylglycinamidine synthase activity
Sa5Y_RS10145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sa5Y_RS10155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Sa5Y_RS10165	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Sa5Y_RS10200	COG0484	heat shock protein binding
Sa5Y_RS10205	COG0443	Heat shock 70 kDa protein
Sa5Y_RS10210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Sa5Y_RS10215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Sa5Y_RS10220	COG0497	DNA recombination
Sa5Y_RS10225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa5Y_RS10230	COG2914	Belongs to the UPF0125 (RnfH) family
Sa5Y_RS10235	COG2867	negative regulation of translational initiation
Sa5Y_RS10240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Sa5Y_RS10250	COG0582	viral genome integration into host DNA
Sa5Y_RS10275	COG0732	type I restriction modification DNA specificity domain
Sa5Y_RS10280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Sa5Y_RS10330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sa5Y_RS10335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Sa5Y_RS10390	COG0514	ATP-dependent DNA helicase (RecQ)
Sa5Y_RS10420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Sa5Y_RS10425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Sa5Y_RS10430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sa5Y_RS10455	COG3051	citrate lyase alpha subunit
Sa5Y_RS10460	COG2301	Belongs to the HpcH HpaI aldolase family
Sa5Y_RS10465	COG3052	prosthetic group binding
Sa5Y_RS10470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
Sa5Y_RS10480	COG3630	sodium ion export across plasma membrane
Sa5Y_RS10485	COG5016	pyruvate
Sa5Y_RS10485	COG0511	ligase activity, forming carbon-carbon bonds
Sa5Y_RS10490	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Sa5Y_RS10500	COG4565	transcriptional regulatory protein
Sa5Y_RS10515	COG0583	DNA-binding transcription factor activity
Sa5Y_RS10525	COG1115	amino acid carrier protein
Sa5Y_RS10530	COG2977	Belongs to the P-Pant transferase superfamily
Sa5Y_RS10535	COG1120	ATPase activity
Sa5Y_RS10540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa5Y_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa5Y_RS10550	COG4592	Periplasmic binding protein
Sa5Y_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
Sa5Y_RS10565	COG1169	isochorismate synthase
Sa5Y_RS10570	COG1021	2,3-dihydroxybenzoate-AMP ligase
Sa5Y_RS10575	COG1535	isochorismatase
Sa5Y_RS10575	COG3433	isochorismatase activity
Sa5Y_RS10580	COG1584	GPR1 FUN34 yaaH family protein
Sa5Y_RS10590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Sa5Y_RS10590	COG0519	Catalyzes the synthesis of GMP from XMP
Sa5Y_RS10595	COG0516	GMP reductase activity
Sa5Y_RS10595	COG0517	IMP dehydrogenase activity
Sa5Y_RS10600	COG1570	exodeoxyribonuclease VII activity
Sa5Y_RS10615	COG1160	GTP binding
Sa5Y_RS10620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa5Y_RS10625	COG2976	Protein conserved in bacteria
Sa5Y_RS10630	COG0124	histidyl-tRNA synthetase
Sa5Y_RS10635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Sa5Y_RS10650	COG0105	UTP biosynthetic process
Sa5Y_RS10655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Sa5Y_RS10660	COG2975	iron-sulfur cluster assembly
Sa5Y_RS10665	COG0633	Ferredoxin
Sa5Y_RS10685	COG0822	iron-sulfur transferase activity
Sa5Y_RS10695	COG1959	2 iron, 2 sulfur cluster binding
Sa5Y_RS10705	COG0483	inositol monophosphate 1-phosphatase activity
Sa5Y_RS10710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sa5Y_RS10715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sa5Y_RS10720	COG1862	Preprotein translocase
Sa5Y_RS10735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Sa5Y_RS10740	COG0517	IMP dehydrogenase activity
Sa5Y_RS10750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Sa5Y_RS10755	COG0583	DNA-binding transcription factor activity
Sa5Y_RS10760	COG0450	alkyl hydroperoxide reductase
Sa5Y_RS10765	COG3142	Participates in the control of copper homeostasis
Sa5Y_RS10780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sa5Y_RS10785	COG0581	inorganic phosphate transmembrane transporter activity
Sa5Y_RS10795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Sa5Y_RS10800	COG0248	Ppx GppA phosphatase
Sa5Y_RS10810	COG5002	protein histidine kinase activity
Sa5Y_RS10815	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS10825	COG0826	peptidase U32
Sa5Y_RS10830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Sa5Y_RS10875	COG0542	response to heat
Sa5Y_RS10885	COG0564	pseudouridine synthase activity
Sa5Y_RS10890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa5Y_RS10895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Sa5Y_RS10900	COG1605	Chorismate mutase
Sa5Y_RS10900	COG0077	Prephenate dehydratase
Sa5Y_RS10905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Sa5Y_RS10910	COG5001	Diguanylate cyclase
Sa5Y_RS10920	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Sa5Y_RS10930	COG0488	(ABC) transporter
Sa5Y_RS10940	COG0287	Prephenate dehydrogenase
Sa5Y_RS10940	COG1605	Chorismate mutase
Sa5Y_RS10945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Sa5Y_RS10950	COG3275	phosphorelay sensor kinase activity
Sa5Y_RS10955	COG3279	Response regulator of the LytR AlgR family
Sa5Y_RS10965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Sa5Y_RS10970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Sa5Y_RS10985	COG1966	Carbon starvation protein
Sa5Y_RS10990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Sa5Y_RS10995	COG1047	Peptidyl-prolyl cis-trans
Sa5Y_RS11000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Sa5Y_RS11010	COG0196	riboflavin kinase activity
Sa5Y_RS11015	COG0728	peptidoglycan biosynthetic process
Sa5Y_RS11020	COG0268	Binds directly to 16S ribosomal RNA
Sa5Y_RS11025	COG0640	Transcriptional regulator
Sa5Y_RS11030	COG0583	DNA-binding transcription factor activity
Sa5Y_RS11035	COG1283	sodium-dependent phosphate transmembrane transporter activity
Sa5Y_RS11045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Sa5Y_RS11050	COG0730	response to heat
Sa5Y_RS11055	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
Sa5Y_RS11060	COG0494	nUDIX hydrolase
Sa5Y_RS11065	COG3066	DNA modification
Sa5Y_RS11070	COG0667	Aldo Keto reductase
Sa5Y_RS11080	COG2204	response regulator
Sa5Y_RS11085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Sa5Y_RS11105	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS11130	COG3153	acetyltransferase
Sa5Y_RS11135	COG3154	lipid carrier protein
Sa5Y_RS11145	COG0826	peptidase U32
Sa5Y_RS11150	COG0826	peptidase U32
Sa5Y_RS11170	COG1185	polyribonucleotide nucleotidyltransferase activity
Sa5Y_RS11175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Sa5Y_RS11185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Sa5Y_RS11190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Sa5Y_RS11195	COG0195	Participates in both transcription termination and antitermination
Sa5Y_RS11200	COG0779	Required for maturation of 30S ribosomal subunits
Sa5Y_RS11215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Sa5Y_RS11230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Sa5Y_RS11235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sa5Y_RS11240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Sa5Y_RS11245	COG1534	Rna-binding protein
Sa5Y_RS11250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sa5Y_RS11255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Sa5Y_RS11260	COG2027	D-alanyl-D-alanine carboxypeptidase
Sa5Y_RS11265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Sa5Y_RS11270	COG0739	heme binding
Sa5Y_RS11285	COG0316	Belongs to the HesB IscA family
Sa5Y_RS11290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Sa5Y_RS11295	COG0628	permease
Sa5Y_RS11300	COG2813	Specifically methylates the guanine in position
Sa5Y_RS11305	COG2205	protein histidine kinase activity
Sa5Y_RS11305	COG0784	Response regulator, receiver
Sa5Y_RS11315	COG0747	negative chemotaxis
Sa5Y_RS11320	COG0601	transmembrane transport
Sa5Y_RS11325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa5Y_RS11330	COG0444	Belongs to the ABC transporter superfamily
Sa5Y_RS11335	COG4608	Belongs to the ABC transporter superfamily
Sa5Y_RS11345	COG2971	BadF BadG BcrA BcrD
Sa5Y_RS11365	COG3842	ATPase activity
Sa5Y_RS11375	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa5Y_RS11380	COG0004	ammonium transporteR
Sa5Y_RS11385	COG0347	Belongs to the P(II) protein family
Sa5Y_RS11390	COG3112	Uncharacterised protein family (UPF0231)
Sa5Y_RS11395	COG1049	propionate catabolic process, 2-methylcitrate cycle
Sa5Y_RS11400	COG1752	Esterase of the alpha-beta hydrolase superfamily
Sa5Y_RS11405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sa5Y_RS11410	COG1643	Atp-dependent helicase
Sa5Y_RS11420	COG1489	DNA binding
Sa5Y_RS11430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sa5Y_RS11440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sa5Y_RS11445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Sa5Y_RS11450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Sa5Y_RS11455	COG0842	Transport permease protein
Sa5Y_RS11460	COG1131	(ABC) transporter
Sa5Y_RS11465	COG0659	secondary active sulfate transmembrane transporter activity
Sa5Y_RS11470	COG0288	reversible hydration of carbon dioxide
Sa5Y_RS11490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Sa5Y_RS11495	COG3107	peptidoglycan biosynthetic process
Sa5Y_RS11500	COG0792	nuclease activity
Sa5Y_RS11505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Sa5Y_RS11510	COG2823	Periplasmic or secreted lipoprotein
Sa5Y_RS11515	COG2969	positive regulation of protein catabolic process
Sa5Y_RS11520	COG0625	glutathione transferase activity
Sa5Y_RS11525	COG2857	Cytochrome c1
Sa5Y_RS11530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Sa5Y_RS11535	COG0723	plastoquinol--plastocyanin reductase activity
Sa5Y_RS11540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Sa5Y_RS11545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Sa5Y_RS11550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Sa5Y_RS11560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sa5Y_RS11565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sa5Y_RS11570	COG0335	large ribosomal subunit rRNA binding
Sa5Y_RS11575	COG0336	Belongs to the RNA methyltransferase TrmD family
Sa5Y_RS11580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Sa5Y_RS11585	COG0228	four-way junction DNA binding
Sa5Y_RS11590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Sa5Y_RS11595	COG4137	Cytochrome C assembly protein
Sa5Y_RS11600	COG4536	flavin adenine dinucleotide binding
Sa5Y_RS11605	COG1854	S-ribosylhomocysteine lyase activity
Sa5Y_RS11610	COG2918	glutathione biosynthetic process
Sa5Y_RS11615	COG0612	Peptidase, M16
Sa5Y_RS11620	COG1238	metal cluster binding
Sa5Y_RS11630	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Sa5Y_RS11635	COG5016	pyruvate
Sa5Y_RS11635	COG0511	ligase activity, forming carbon-carbon bonds
Sa5Y_RS11640	COG3630	sodium ion export across plasma membrane
Sa5Y_RS11685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Sa5Y_RS11690	COG0527	aspartate kinase activity
Sa5Y_RS11695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Sa5Y_RS11700	COG2137	regulation of response to DNA damage stimulus
Sa5Y_RS11705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Sa5Y_RS11715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Sa5Y_RS11720	COG4208	sulfate ABC transporter
Sa5Y_RS11740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Sa5Y_RS11745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sa5Y_RS11755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sa5Y_RS11760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Sa5Y_RS11765	COG0585	pseudouridine synthase activity
Sa5Y_RS11770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Sa5Y_RS11775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Sa5Y_RS11780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Sa5Y_RS11785	COG1968	undecaprenyl-diphosphatase activity
Sa5Y_RS11790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sa5Y_RS11795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Sa5Y_RS11805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Sa5Y_RS11815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Sa5Y_RS11820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Sa5Y_RS11825	COG1610	YqeY-like protein
Sa5Y_RS11830	COG0358	DNA primase activity
Sa5Y_RS11850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa5Y_RS11855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sa5Y_RS11860	COG1349	DNA-binding transcription factor activity
Sa5Y_RS11880	COG1279	arginine transmembrane transporter activity
Sa5Y_RS11885	COG0668	transmembrane transport
Sa5Y_RS11895	COG0191	fructose-bisphosphate aldolase activity
Sa5Y_RS11900	COG0126	phosphoglycerate kinase activity
Sa5Y_RS11905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Sa5Y_RS11910	COG4771	TonB-dependent receptor
Sa5Y_RS11915	COG0583	DNA-binding transcription factor activity
Sa5Y_RS11920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Sa5Y_RS11925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Sa5Y_RS11930	COG3091	SprT-like family
Sa5Y_RS11935	COG2356	endonuclease I
Sa5Y_RS11940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Sa5Y_RS11945	COG0189	ligase activity
Sa5Y_RS11950	COG1678	Uncharacterized ACR, COG1678
Sa5Y_RS11955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Sa5Y_RS11960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Sa5Y_RS11980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Sa5Y_RS11985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Sa5Y_RS11990	COG0762	integral membrane protein
Sa5Y_RS12005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Sa5Y_RS12010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sa5Y_RS12015	COG2066	Belongs to the glutaminase family
Sa5Y_RS12020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Sa5Y_RS12025	COG1194	a g-specific adenine glycosylase
Sa5Y_RS12030	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Sa5Y_RS12035	COG0741	lytic transglycosylase activity
Sa5Y_RS12090	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Sa5Y_RS12095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Sa5Y_RS12100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sa5Y_RS12105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Sa5Y_RS12110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Sa5Y_RS12115	COG2967	ApaG domain
Sa5Y_RS12120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Sa5Y_RS12135	COG3610	response to peptide
Sa5Y_RS12140	COG2966	Psort location CytoplasmicMembrane, score
Sa5Y_RS12145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Sa5Y_RS12150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Sa5Y_RS12155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Sa5Y_RS12160	COG0142	geranyltranstransferase activity
Sa5Y_RS12165	COG0531	amino acid
Sa5Y_RS12170	COG0039	L-malate dehydrogenase activity
Sa5Y_RS12175	COG1438	arginine binding
Sa5Y_RS12185	COG2358	TRAP transporter, solute receptor (TAXI family
Sa5Y_RS12195	COG0589	response to stress
Sa5Y_RS12220	COG2235	arginine
Sa5Y_RS12225	COG0312	modulator of DNA gyrase
Sa5Y_RS12230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa5Y_RS12235	COG3164	Protein of unknown function
Sa5Y_RS12245	COG0424	maF-like protein
Sa5Y_RS12250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Sa5Y_RS12255	COG1792	Involved in formation and maintenance of cell shape
Sa5Y_RS12260	COG1077	Cell shape determining protein MreB Mrl
Sa5Y_RS12290	COG2165	general secretion pathway protein
Sa5Y_RS12295	COG2165	general secretion pathway protein
Sa5Y_RS12305	COG1459	type II secretion system
Sa5Y_RS12310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Sa5Y_RS12320	COG3409	Peptidoglycan-binding domain 1 protein
Sa5Y_RS12320	COG3267	Type II secretory pathway component ExeA
Sa5Y_RS12345	COG2199	diguanylate cyclase activity
Sa5Y_RS12345	COG2200	EAL domain
Sa5Y_RS12350	COG0629	single-stranded DNA binding
Sa5Y_RS12365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Sa5Y_RS12375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Sa5Y_RS12380	COG0527	aspartate kinase activity
Sa5Y_RS12385	COG1410	methionine synthase
Sa5Y_RS12385	COG0646	methionine synthase
Sa5Y_RS12460	COG0175	sulfate reduction
Sa5Y_RS12465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sa5Y_RS12470	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Sa5Y_RS12495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Sa5Y_RS12500	COG0735	belongs to the Fur family
Sa5Y_RS12515	COG0166	Belongs to the GPI family
Sa5Y_RS12520	COG0432	Pfam Uncharacterised protein family UPF0047
Sa5Y_RS12525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Sa5Y_RS12540	COG0359	binds to the 23S rRNA
Sa5Y_RS12545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Sa5Y_RS12550	COG2965	DNA replication, synthesis of RNA primer
Sa5Y_RS12555	COG0360	Binds together with S18 to 16S ribosomal RNA
Sa5Y_RS12565	COG2906	2 iron, 2 sulfur cluster binding
Sa5Y_RS12570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sa5Y_RS12575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sa5Y_RS12580	COG0049	tRNA binding
Sa5Y_RS12595	COG2923	Belongs to the DsrF TusC family
Sa5Y_RS12600	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Sa5Y_RS12605	COG2964	Protein conserved in bacteria
Sa5Y_RS12610	COG0545	Peptidyl-prolyl cis-trans isomerase
Sa5Y_RS12620	COG2900	Belongs to the SlyX family
Sa5Y_RS12625	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Sa5Y_RS12630	COG0330	HflC and HflK could
Sa5Y_RS12635	COG0330	HflC and HflK could
Sa5Y_RS12640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Sa5Y_RS12645	COG1923	regulation of RNA biosynthetic process
Sa5Y_RS12650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Sa5Y_RS12655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Sa5Y_RS12665	COG0802	atpase or kinase
Sa5Y_RS12670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Sa5Y_RS12720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Sa5Y_RS12725	COG1162	GTPase activity
Sa5Y_RS12730	COG0688	phosphatidylethanolamine metabolic process
Sa5Y_RS12735	COG0471	metal ion transport
Sa5Y_RS12745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Sa5Y_RS12750	COG4942	peptidase
Sa5Y_RS12765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Sa5Y_RS12770	COG2816	NAD+ diphosphatase activity
Sa5Y_RS12775	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Sa5Y_RS12780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Sa5Y_RS12785	COG0085	RNA polymerase activity
Sa5Y_RS12790	COG0222	ribosome binding
Sa5Y_RS12795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Sa5Y_RS12805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Sa5Y_RS12810	COG0250	Participates in transcription elongation, termination and antitermination
Sa5Y_RS12815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Sa5Y_RS12820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sa5Y_RS12845	COG1072	(Pantothenic acid kinase))
Sa5Y_RS12855	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Sa5Y_RS12865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sa5Y_RS12915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Sa5Y_RS12930	COG3118	belongs to the thioredoxin family
Sa5Y_RS12935	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS12940	COG0248	Ppx GppA phosphatase
Sa5Y_RS12945	COG2205	protein histidine kinase activity
Sa5Y_RS12945	COG0784	Response regulator, receiver
Sa5Y_RS12950	COG2814	Major facilitator Superfamily
Sa5Y_RS12970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sa5Y_RS12975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Sa5Y_RS12980	COG0511	ligase activity, forming carbon-carbon bonds
Sa5Y_RS12985	COG0439	Biotin carboxylase
Sa5Y_RS12990	COG2264	protein methyltransferase activity
Sa5Y_RS12995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Sa5Y_RS13000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Sa5Y_RS13005	COG1609	Transcriptional regulator
Sa5Y_RS13020	COG0129	dihydroxy-acid dehydratase activity
Sa5Y_RS13025	COG3265	gluconokinase activity
Sa5Y_RS13030	COG2610	gluconate transmembrane transporter activity
Sa5Y_RS13035	COG0800	Aldolase
Sa5Y_RS13055	COG0840	transmembrane signaling receptor activity
Sa5Y_RS13060	COG1982	Orn Lys Arg decarboxylase major
Sa5Y_RS13065	COG0531	amino acid
Sa5Y_RS13070	COG3710	Transcriptional regulator
Sa5Y_RS13075	COG0789	Transcriptional regulator
Sa5Y_RS13090	COG0151	Belongs to the GarS family
Sa5Y_RS13100	COG0776	regulation of translation
Sa5Y_RS13105	COG1253	flavin adenine dinucleotide binding
Sa5Y_RS13140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa5Y_RS13145	COG3068	Protein conserved in bacteria
Sa5Y_RS13155	COG1573	uracil-dna glycosylase
Sa5Y_RS13160	COG0668	transmembrane transport
Sa5Y_RS13165	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Sa5Y_RS13175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sa5Y_RS13230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Sa5Y_RS13240	COG2089	acid synthase
Sa5Y_RS13250	COG1083	cytidylyl-transferase
Sa5Y_RS13255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Sa5Y_RS13260	COG1086	Polysaccharide biosynthesis protein
Sa5Y_RS13265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Sa5Y_RS13275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sa5Y_RS13285	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
Sa5Y_RS13290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa5Y_RS13320	COG0859	PFAM glycosyl transferase family 9
Sa5Y_RS13330	COG1519	Transferase
Sa5Y_RS13355	COG3642	lipopolysaccharide core region biosynthetic process
Sa5Y_RS13360	COG0859	PFAM glycosyl transferase family 9
Sa5Y_RS13365	COG0463	Glycosyl transferase, family 2
Sa5Y_RS13370	COG0859	PFAM glycosyl transferase family 9
Sa5Y_RS13375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Sa5Y_RS13380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Sa5Y_RS13390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Sa5Y_RS13395	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Sa5Y_RS13400	COG2003	Belongs to the UPF0758 family
Sa5Y_RS13410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sa5Y_RS13420	COG1309	transcriptional regulator
Sa5Y_RS13425	COG1560	Kdo2-lipid A biosynthetic process
Sa5Y_RS13430	COG1560	Kdo2-lipid A biosynthetic process
Sa5Y_RS13435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Sa5Y_RS13440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Sa5Y_RS13445	COG1561	YicC-like family, N-terminal region
Sa5Y_RS13510	COG2862	Uncharacterized protein family, UPF0114
Sa5Y_RS13515	COG1263	PTS System
Sa5Y_RS13515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa5Y_RS13520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Sa5Y_RS13540	COG0514	ATP-dependent DNA helicase (RecQ)
Sa5Y_RS13545	COG2962	Rard protein
Sa5Y_RS13550	COG0405	Gamma-glutamyltransferase
Sa5Y_RS13560	COG1280	lysine exporter protein (LysE YggA)
Sa5Y_RS13570	COG0210	DNA helicase
Sa5Y_RS13580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Sa5Y_RS13585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa5Y_RS13595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa5Y_RS13600	COG0601	transmembrane transport
Sa5Y_RS13605	COG0747	negative chemotaxis
Sa5Y_RS13660	COG1309	transcriptional regulator
Sa5Y_RS13665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa5Y_RS13670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sa5Y_RS13675	COG2960	long-chain fatty acid transporting porin activity
Sa5Y_RS13680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Sa5Y_RS13685	COG0583	DNA-binding transcription factor activity
Sa5Y_RS13755	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
Sa5Y_RS13760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Sa5Y_RS13765	COG1739	Uncharacterized protein family UPF0029
Sa5Y_RS13770	COG1024	Enoyl-CoA hydratase
Sa5Y_RS13770	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa5Y_RS13775	COG0183	Belongs to the thiolase family
Sa5Y_RS13780	COG0583	DNA-binding transcription factor activity
Sa5Y_RS13785	COG2814	Major facilitator Superfamily
Sa5Y_RS13795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Sa5Y_RS13800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Sa5Y_RS13805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Sa5Y_RS13810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Sa5Y_RS13815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sa5Y_RS13820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sa5Y_RS13850	COG0357	Ribosomal RNA small subunit methyltransferase G
Sa5Y_RS13865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Sa5Y_RS13870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Sa5Y_RS13875	COG0706	membrane insertase activity
Sa5Y_RS13885	COG0594	ribonuclease P activity
Sa5Y_RS13890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Sa5Y_RS13895	COG1126	abc transporter atp-binding protein
Sa5Y_RS13945	COG0217	transcriptional regulatory protein
Sa5Y_RS13950	COG2084	Dehydrogenase
Sa5Y_RS13970	COG2909	trisaccharide binding
Sa5Y_RS13975	COG0058	SHG alpha-glucan phosphorylase activity
Sa5Y_RS13980	COG1640	4-alpha-glucanotransferase
Sa5Y_RS13985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Sa5Y_RS14000	COG3501	Rhs element vgr protein
Sa5Y_RS14005	COG4104	PAAR repeat-containing protein
Sa5Y_RS14035	COG0471	metal ion transport
Sa5Y_RS14040	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Sa5Y_RS14085	COG0671	phosphoesterase, PA-phosphatase related
Sa5Y_RS14090	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Sa5Y_RS14100	COG1999	signal sequence binding
Sa5Y_RS14115	COG0786	glutamate:sodium symporter activity
Sa5Y_RS14150	COG0813	purine-nucleoside phosphorylase activity
Sa5Y_RS14160	COG3272	Protein of unknown function (DUF1722)
Sa5Y_RS14170	COG0415	Belongs to the DNA photolyase family
Sa5Y_RS14175	COG1388	LysM domain
Sa5Y_RS14175	COG1376	ErfK ybiS ycfS ynhG family protein
Sa5Y_RS14185	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS14190	COG1770	oligopeptidase
Sa5Y_RS14220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sa5Y_RS14225	COG0573	inorganic phosphate transmembrane transporter activity
Sa5Y_RS14230	COG0581	inorganic phosphate transmembrane transporter activity
Sa5Y_RS14235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sa5Y_RS14255	COG3314	Sporulation integral membrane protein YlbJ
Sa5Y_RS14260	COG0659	secondary active sulfate transmembrane transporter activity
Sa5Y_RS14270	COG0739	heme binding
Sa5Y_RS14275	COG5001	Diguanylate cyclase
Sa5Y_RS14275	COG3300	MHYT domain
Sa5Y_RS14280	COG0583	DNA-binding transcription factor activity
Sa5Y_RS14285	COG2814	Major facilitator Superfamily
Sa5Y_RS14310	COG1301	dicarboxylic acid transport
Sa5Y_RS14320	COG1342	Belongs to the UPF0251 family
Sa5Y_RS14355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Sa5Y_RS14360	COG0673	inositol 2-dehydrogenase activity
Sa5Y_RS14370	COG2771	luxR family
Sa5Y_RS14370	COG2200	EAL domain
Sa5Y_RS14375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sa5Y_RS14385	COG0564	pseudouridine synthase activity
Sa5Y_RS14450	COG3829	transcription factor binding
Sa5Y_RS14495	COG1869	D-ribose catabolic process
Sa5Y_RS14500	COG1129	ABC transporter
Sa5Y_RS14505	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa5Y_RS14510	COG1879	ABC-type sugar transport system periplasmic component
Sa5Y_RS14515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa5Y_RS14520	COG1609	Transcriptional regulator
Sa5Y_RS14530	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Sa5Y_RS14540	COG0584	glycerophosphoryl diester phosphodiesterase
Sa5Y_RS14545	COG2271	Major facilitator Superfamily
Sa5Y_RS14580	COG0579	oxidoreductase
Sa5Y_RS14590	COG0242	peptide deformylase activity
Sa5Y_RS14595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Sa5Y_RS14595	COG1017	nitric oxide dioxygenase activity
Sa5Y_RS14600	COG1320	monovalent cation:proton antiporter activity
Sa5Y_RS14605	COG2212	antiporter activity
Sa5Y_RS14610	COG1863	multisubunit Na H antiporter MnhE subunit
Sa5Y_RS14615	COG0651	ATP synthesis coupled electron transport
Sa5Y_RS14620	COG1006	Multisubunit Na H antiporter MnhC subunit
Sa5Y_RS14625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Sa5Y_RS14625	COG2111	Na H antiporter
Sa5Y_RS14635	COG0589	response to stress
Sa5Y_RS14665	COG5001	Diguanylate cyclase
Sa5Y_RS14665	COG5002	protein histidine kinase activity
Sa5Y_RS14670	COG1278	Cold shock
Sa5Y_RS14685	COG2304	oxidoreductase activity
Sa5Y_RS14705	COG0714	Associated with various cellular activities
Sa5Y_RS14710	COG0840	transmembrane signaling receptor activity
Sa5Y_RS14725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Sa5Y_RS14730	COG2195	Cleaves the N-terminal amino acid of tripeptides
Sa5Y_RS14740	COG3604	Transcriptional regulator
Sa5Y_RS14745	COG1017	nitric oxide dioxygenase activity
Sa5Y_RS14745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Sa5Y_RS14750	COG1278	Cold shock
Sa5Y_RS14755	COG3036	rescue of stalled ribosome
Sa5Y_RS14780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Sa5Y_RS14780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Sa5Y_RS14785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa5Y_RS14795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sa5Y_RS14810	COG0516	GMP reductase activity
Sa5Y_RS14820	COG1204	response to ionizing radiation
Sa5Y_RS14825	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS14830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Sa5Y_RS14835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Sa5Y_RS14840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Sa5Y_RS14845	COG0784	Response regulator, receiver
Sa5Y_RS14845	COG3437	response regulator, receiver
Sa5Y_RS14850	COG4191	Histidine kinase
Sa5Y_RS14850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa5Y_RS14860	COG1757	Na H antiporter
Sa5Y_RS14865	COG2814	Major facilitator Superfamily
Sa5Y_RS14875	COG3240	lipase activity
Sa5Y_RS14885	COG0840	transmembrane signaling receptor activity
Sa5Y_RS14890	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Sa5Y_RS14895	COG5380	lipid catabolic process
Sa5Y_RS14920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa5Y_RS14925	COG4605	iron ion homeostasis
Sa5Y_RS14930	COG4604	ABC transporter, ATP-binding protein
Sa5Y_RS14935	COG2207	Transcriptional regulator
Sa5Y_RS14950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Sa5Y_RS14980	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Sa5Y_RS15015	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS15025	COG3623	hexulose-6-phosphate isomerase
Sa5Y_RS15030	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Sa5Y_RS15035	COG0561	phosphatase activity
Sa5Y_RS15070	COG0366	Alpha amylase catalytic
Sa5Y_RS15090	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS15095	COG5002	protein histidine kinase activity
Sa5Y_RS15120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa5Y_RS15135	COG2814	Major facilitator Superfamily
Sa5Y_RS15150	COG1686	Belongs to the peptidase S11 family
Sa5Y_RS15170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Sa5Y_RS15170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Sa5Y_RS15175	COG0509	glycine decarboxylation via glycine cleavage system
Sa5Y_RS15180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Sa5Y_RS15190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa5Y_RS15205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Sa5Y_RS15210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Sa5Y_RS15250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS15420	COG0384	phenazine biosynthesis protein PhzF
Sa5Y_RS15535	COG0456	acetyltransferase
Sa5Y_RS15565	COG0346	lactoylglutathione lyase activity
Sa5Y_RS15810	COG2944	sequence-specific DNA binding
Sa5Y_RS15905	COG3040	lipid binding
Sa5Y_RS15925	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Sa5Y_RS16065	COG0454	-acetyltransferase
Sa5Y_RS16075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS16090	COG3041	Addiction module toxin RelE StbE family
Sa5Y_RS16115	COG4977	sequence-specific DNA binding
Sa5Y_RS16160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Sa5Y_RS16225	COG0384	phenazine biosynthesis protein PhzF
Sa5Y_RS16365	COG2176	DNA-directed DNA polymerase activity
Sa5Y_RS16465	COG0456	acetyltransferase
Sa5Y_RS16600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS16670	COG3549	Plasmid maintenance system killer
Sa5Y_RS16675	COG3093	addiction module antidote protein HigA
Sa5Y_RS16735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Sa5Y_RS16750	COG2357	RelA SpoT domain protein
Sa5Y_RS16805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Sa5Y_RS16955	COG5642	Protein of unknown function (DUF2384)
Sa5Y_RS16965	COG0454	-acetyltransferase
Sa5Y_RS16985	COG0456	acetyltransferase
Sa5Y_RS17005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS17020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Sa5Y_RS17025	COG1418	mRNA catabolic process
Sa5Y_RS17040	COG0384	phenazine biosynthesis protein PhzF
Sa5Y_RS17075	COG1619	proteins homologs of microcin C7 resistance protein MccF
Sa5Y_RS17090	COG1328	CTP reductase activity
Sa5Y_RS17095	COG0602	queuosine metabolic process
Sa5Y_RS17105	COG0189	ligase activity
Sa5Y_RS17105	COG4067	protein conserved in archaea
Sa5Y_RS17110	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Sa5Y_RS17110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Sa5Y_RS17110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Sa5Y_RS17115	COG1105	Belongs to the carbohydrate kinase PfkB family
Sa5Y_RS17120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa5Y_RS17120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa5Y_RS17125	COG1609	Transcriptional regulator
Sa5Y_RS17130	COG0420	3'-5' exonuclease activity
Sa5Y_RS17135	COG0419	ATPase involved in DNA repair
Sa5Y_RS17140	COG0784	Response regulator, receiver
Sa5Y_RS17140	COG2205	protein histidine kinase activity
Sa5Y_RS17150	COG0156	8-amino-7-oxononanoate synthase activity
Sa5Y_RS17160	COG0038	chloride channel
Sa5Y_RS17165	COG0523	cobalamin synthesis protein
Sa5Y_RS17175	COG3158	transport of potassium into the cell
Sa5Y_RS17180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Sa5Y_RS17180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa5Y_RS17180	COG1013	pyruvate-flavodoxin oxidoreductase activity
Sa5Y_RS17180	COG0674	pyruvate-flavodoxin oxidoreductase activity
Sa5Y_RS17185	COG2205	protein histidine kinase activity
Sa5Y_RS17195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sa5Y_RS17200	COG0586	Pfam SNARE associated Golgi protein
Sa5Y_RS17210	COG2200	EAL domain
Sa5Y_RS17220	COG3038	cytochrome b561
Sa5Y_RS17230	COG2116	formate transmembrane transporter activity
Sa5Y_RS17235	COG0583	DNA-binding transcription factor activity
Sa5Y_RS17245	COG3593	DNA synthesis involved in DNA repair
Sa5Y_RS17250	COG0737	Belongs to the 5'-nucleotidase family
Sa5Y_RS17265	COG2824	Alkylphosphonate utilization operon protein PhnA
Sa5Y_RS17305	COG2199	diguanylate cyclase activity
Sa5Y_RS17325	COG3706	GGDEF domain
Sa5Y_RS17340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Sa5Y_RS17345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Sa5Y_RS17355	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS17370	COG3140	Belongs to the UPF0181 family
Sa5Y_RS17375	COG0023	Translation Initiation Factor
Sa5Y_RS17395	COG0045	succinate-CoA ligase (ADP-forming) activity
Sa5Y_RS17395	COG1042	CoA-binding domain protein
Sa5Y_RS17395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS17400	COG0583	DNA-binding transcription factor activity
Sa5Y_RS17405	COG1629	transport
Sa5Y_RS17405	COG4771	TonB-dependent receptor
Sa5Y_RS17420	COG2050	protein possibly involved in aromatic compounds catabolism
Sa5Y_RS17445	COG0625	glutathione transferase activity
Sa5Y_RS17460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Sa5Y_RS17465	COG4172	Belongs to the ABC transporter superfamily
Sa5Y_RS17470	COG4239	(ABC) transporter, permease
Sa5Y_RS17475	COG4174	ABC transporter (Permease)
Sa5Y_RS17480	COG4166	transmembrane transport
Sa5Y_RS17505	COG3104	oligopeptide transport
Sa5Y_RS17525	COG3842	ATPase activity
Sa5Y_RS17530	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa5Y_RS17535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Sa5Y_RS17540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Sa5Y_RS17545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sa5Y_RS17550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sa5Y_RS17555	COG1011	Hydrolase
Sa5Y_RS17565	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Sa5Y_RS17570	COG1970	mechanosensitive ion channel activity
Sa5Y_RS17575	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Sa5Y_RS17580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa5Y_RS17580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa5Y_RS17585	COG0302	gtp cyclohydrolase
Sa5Y_RS17595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Sa5Y_RS17605	COG2897	thiosulfate sulfurtransferase activity
Sa5Y_RS17610	COG2390	Transcriptional regulator
Sa5Y_RS17625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Sa5Y_RS17660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sa5Y_RS17685	COG0583	DNA-binding transcription factor activity
Sa5Y_RS17690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Sa5Y_RS17735	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa5Y_RS17780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa5Y_RS17780	COG1263	PTS System
Sa5Y_RS17785	COG1609	Transcriptional regulator
Sa5Y_RS17795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa5Y_RS17800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Sa5Y_RS17810	COG2885	chlorophyll binding
Sa5Y_RS17815	COG0545	Peptidyl-prolyl cis-trans isomerase
Sa5Y_RS17820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sa5Y_RS17825	COG0840	transmembrane signaling receptor activity
Sa5Y_RS17830	COG3069	C4-dicarboxylate transmembrane transporter activity
Sa5Y_RS17835	COG1760	l-serine dehydratase
Sa5Y_RS17840	COG2197	response regulator
Sa5Y_RS17845	COG3850	Histidine kinase
Sa5Y_RS17850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Sa5Y_RS17860	COG0243	molybdopterin cofactor binding
Sa5Y_RS17880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sa5Y_RS17885	COG2197	response regulator
Sa5Y_RS17890	COG3851	Histidine kinase
Sa5Y_RS17895	COG2271	Major facilitator Superfamily
Sa5Y_RS17900	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa5Y_RS17910	COG3842	ATPase activity
Sa5Y_RS17915	COG3243	poly(R)-hydroxyalkanoic acid synthase
Sa5Y_RS17925	COG0183	Belongs to the thiolase family
Sa5Y_RS17935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sa5Y_RS17940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Sa5Y_RS17965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Sa5Y_RS17975	COG1979	alcohol dehydrogenase
Sa5Y_RS17990	COG4191	Histidine kinase
Sa5Y_RS18000	COG2271	Major facilitator Superfamily
Sa5Y_RS18005	COG0469	pyruvate kinase activity
Sa5Y_RS18010	COG2205	protein histidine kinase activity
Sa5Y_RS18010	COG0784	Response regulator, receiver
Sa5Y_RS18010	COG2198	Histidine kinase
Sa5Y_RS18015	COG1879	ABC-type sugar transport system periplasmic component
Sa5Y_RS18020	COG1803	Methylglyoxal synthase
Sa5Y_RS18025	COG1335	isochorismatase
Sa5Y_RS18030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Sa5Y_RS18045	COG0210	DNA helicase
Sa5Y_RS18050	COG1289	transmembrane transporter activity
Sa5Y_RS18080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Sa5Y_RS18085	COG4149	molybdate abc transporter
Sa5Y_RS18090	COG0725	ABC transporter, periplasmic molybdate-binding protein
Sa5Y_RS18095	COG1492	cobalamin metabolic process
Sa5Y_RS18130	COG0784	Response regulator, receiver
Sa5Y_RS18130	COG5002	protein histidine kinase activity
Sa5Y_RS18135	COG1879	ABC-type sugar transport system periplasmic component
Sa5Y_RS18145	COG2827	Endonuclease containing a URI domain
Sa5Y_RS18160	COG2926	Belongs to the UPF0265 family
Sa5Y_RS18175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Sa5Y_RS18180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Sa5Y_RS18185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Sa5Y_RS18190	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
Sa5Y_RS18195	COG0247	lactate metabolic process
Sa5Y_RS18200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sa5Y_RS18205	COG3118	belongs to the thioredoxin family
Sa5Y_RS18230	COG4160	amino acid transport
Sa5Y_RS18235	COG4215	(ABC) transporter
Sa5Y_RS18240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa5Y_RS18245	COG1126	abc transporter atp-binding protein
Sa5Y_RS18255	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Sa5Y_RS18265	COG0494	nUDIX hydrolase
Sa5Y_RS18270	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Sa5Y_RS18280	COG1309	transcriptional regulator
Sa5Y_RS18285	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS18290	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Sa5Y_RS18300	COG0814	amino acid
Sa5Y_RS18305	COG0840	transmembrane signaling receptor activity
Sa5Y_RS18310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Sa5Y_RS18320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Sa5Y_RS18330	COG1984	allophanate hydrolase subunit 2
Sa5Y_RS18345	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Sa5Y_RS18350	COG4181	ATPase activity
Sa5Y_RS18360	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Sa5Y_RS18365	COG1716	ATPase activity
Sa5Y_RS18365	COG5001	Diguanylate cyclase
Sa5Y_RS18380	COG0484	heat shock protein binding
Sa5Y_RS18395	COG0546	phosphoglycolate phosphatase activity
Sa5Y_RS18410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa5Y_RS18415	COG1368	sulfuric ester hydrolase activity
Sa5Y_RS18425	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS18440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sa5Y_RS18450	COG3046	protein related to deoxyribodipyrimidine photolyase
Sa5Y_RS18455	COG3397	chitin binding
Sa5Y_RS18475	COG1166	arginine decarboxylase activity
Sa5Y_RS18485	COG2239	Acts as a magnesium transporter
Sa5Y_RS18490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Sa5Y_RS18495	COG0459	protein refolding
Sa5Y_RS18505	COG0527	aspartate kinase activity
Sa5Y_RS18510	COG0662	Cupin 2, conserved barrel domain protein
Sa5Y_RS18515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Sa5Y_RS18520	COG0456	acetyltransferase
Sa5Y_RS18525	COG2154	pterin-4-alpha-carbinolamine dehydratase
Sa5Y_RS18530	COG3186	Phenylalanine-4-hydroxylase
Sa5Y_RS18535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sa5Y_RS18555	COG2264	protein methyltransferase activity
Sa5Y_RS18580	COG1253	flavin adenine dinucleotide binding
Sa5Y_RS18585	COG1765	OsmC-like protein
Sa5Y_RS18620	COG1252	NADH dehydrogenase
Sa5Y_RS18625	COG0531	amino acid
Sa5Y_RS18640	COG3279	Response regulator of the LytR AlgR family
Sa5Y_RS18645	COG3275	phosphorelay sensor kinase activity
Sa5Y_RS18660	COG1136	(ABC) transporter
Sa5Y_RS18660	COG0577	efflux transmembrane transporter activity
Sa5Y_RS18665	COG1136	(ABC) transporter
Sa5Y_RS18675	COG4989	oxidoreductase activity
Sa5Y_RS18680	COG0366	Alpha amylase catalytic
Sa5Y_RS18695	COG2067	long-chain fatty acid transport protein
Sa5Y_RS18700	COG2267	carboxylic ester hydrolase activity
Sa5Y_RS18710	COG3227	Zinc metalloprotease (Elastase)
Sa5Y_RS18715	COG3047	cAMP biosynthetic process
Sa5Y_RS18725	COG1686	Belongs to the peptidase S11 family
Sa5Y_RS18730	COG0557	exoribonuclease II activity
Sa5Y_RS18735	COG1278	Cold shock
Sa5Y_RS18745	COG3048	D-serine ammonia-lyase activity
Sa5Y_RS18750	COG0583	DNA-binding transcription factor activity
Sa5Y_RS18780	COG1063	alcohol dehydrogenase
Sa5Y_RS18790	COG2873	o-acetylhomoserine
Sa5Y_RS18800	COG0346	lactoylglutathione lyase activity
Sa5Y_RS18820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Sa5Y_RS18825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sa5Y_RS18830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Sa5Y_RS18835	COG0363	glucosamine-6-phosphate deaminase activity
Sa5Y_RS18840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Sa5Y_RS18865	COG1929	Belongs to the glycerate kinase type-1 family
Sa5Y_RS18870	COG2610	gluconate transmembrane transporter activity
Sa5Y_RS18875	COG3835	regulator
Sa5Y_RS18885	COG0748	coenzyme F420 binding
Sa5Y_RS18890	COG3721	Heme iron utilization protein
Sa5Y_RS18900	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Sa5Y_RS18905	COG0811	peptide transport
Sa5Y_RS18910	COG0848	biopolymer transport protein
Sa5Y_RS18915	COG4558	Periplasmic binding protein
Sa5Y_RS18920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa5Y_RS18925	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Sa5Y_RS18960	COG0633	Ferredoxin
Sa5Y_RS18960	COG3217	Mosc domain protein beta barrel domain protein
Sa5Y_RS18960	COG0633	Ferredoxin
Sa5Y_RS18960	COG3217	Mosc domain protein beta barrel domain protein
Sa5Y_RS18965	COG0418	dihydroorotase activity
Sa5Y_RS18975	COG3152	Membrane
Sa5Y_RS18985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Sa5Y_RS18990	COG2354	Protein conserved in bacteria
Sa5Y_RS19000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sa5Y_RS19005	COG1278	Cold shock
Sa5Y_RS19035	COG2199	diguanylate cyclase activity
Sa5Y_RS19040	COG1349	DNA-binding transcription factor activity
Sa5Y_RS19055	COG3833	ABC-type maltose transport systems, permease component
Sa5Y_RS19060	COG1175	transmembrane transport
Sa5Y_RS19070	COG3842	ATPase activity
Sa5Y_RS19075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Sa5Y_RS19090	COG0393	Putative heavy-metal-binding
Sa5Y_RS19100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sa5Y_RS19105	COG0835	chemotaxis
Sa5Y_RS19105	COG0784	Response regulator, receiver
Sa5Y_RS19110	COG1846	Transcriptional regulator
Sa5Y_RS19115	COG3706	GGDEF domain
Sa5Y_RS19155	COG0583	DNA-binding transcription factor activity
Sa5Y_RS19160	COG5001	Diguanylate cyclase
Sa5Y_RS19170	COG1741	Belongs to the pirin family
Sa5Y_RS19175	COG3123	guanosine phosphorylase activity
Sa5Y_RS19185	COG2211	Major facilitator Superfamily
Sa5Y_RS19195	COG0840	transmembrane signaling receptor activity
Sa5Y_RS19200	COG1067	ATP-dependent peptidase activity
Sa5Y_RS19210	COG4172	Belongs to the ABC transporter superfamily
Sa5Y_RS19230	COG0583	DNA-binding transcription factor activity
Sa5Y_RS19235	COG1620	l-lactate permease
Sa5Y_RS19250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Sa5Y_RS19270	COG0513	Belongs to the DEAD box helicase family
Sa5Y_RS19280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Sa5Y_RS19295	COG1132	(ABC) transporter
Sa5Y_RS19305	COG1902	pentaerythritol trinitrate reductase activity
Sa5Y_RS19315	COG1280	lysine exporter protein (LysE YggA)
Sa5Y_RS19320	COG2207	Transcriptional regulator
Sa5Y_RS19340	COG1846	Transcriptional regulator
Sa5Y_RS19345	COG1764	response to oxidative stress
Sa5Y_RS19350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Sa5Y_RS19355	COG0697	spore germination
Sa5Y_RS19365	COG0700	Nucleoside recognition
Sa5Y_RS19370	COG3366	ferrous iron transmembrane transporter activity
Sa5Y_RS19375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Sa5Y_RS19380	COG4565	transcriptional regulatory protein
Sa5Y_RS19390	COG0471	metal ion transport
Sa5Y_RS19400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Sa5Y_RS19405	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Sa5Y_RS19410	COG2259	Doxx family
Sa5Y_RS19435	COG0363	glucosamine-6-phosphate deaminase activity
Sa5Y_RS19455	COG4580	involved in the transport of maltose and maltodextrins
Sa5Y_RS19470	COG0840	transmembrane signaling receptor activity
Sa5Y_RS19480	COG0840	transmembrane signaling receptor activity
Sa5Y_RS19490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Sa5Y_RS19495	COG1126	abc transporter atp-binding protein
Sa5Y_RS19505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa5Y_RS19510	COG4597	amino acid ABC transporter
Sa5Y_RS19515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sa5Y_RS19520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa5Y_RS19520	COG2213	PTS system mannitol-specific
Sa5Y_RS19525	COG0246	Mannitol dehydrogenase
Sa5Y_RS19530	COG3722	fumarate hydratase activity
Sa5Y_RS19535	COG0673	inositol 2-dehydrogenase activity
Sa5Y_RS19560	COG0697	spore germination
Sa5Y_RS19575	COG1335	isochorismatase
Sa5Y_RS19585	COG2910	NAD(P)H-binding
Sa5Y_RS19595	COG0840	transmembrane signaling receptor activity
Sa5Y_RS19600	COG4221	oxidoreductase activity
Sa5Y_RS19610	COG1901	pseudouridine methyltransferase
Sa5Y_RS19625	COG0531	amino acid
Sa5Y_RS19630	COG1982	Orn Lys Arg decarboxylase major
Sa5Y_RS19665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Sa5Y_RS19690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Sa5Y_RS19730	COG0745	RESPONSE REGULATOR receiver
Sa5Y_RS19755	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Sa5Y_RS19760	COG0840	transmembrane signaling receptor activity
Sa5Y_RS19765	COG0835	chemotaxis
Sa5Y_RS19770	COG0835	chemotaxis
Sa5Y_RS19775	COG2198	Histidine kinase
Sa5Y_RS19775	COG0643	Histidine kinase
Sa5Y_RS19795	COG0601	transmembrane transport
Sa5Y_RS19800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa5Y_RS19810	COG2194	sulfuric ester hydrolase activity
Sa5Y_RS19815	COG0642	Histidine kinase
Sa5Y_RS19850	COG1444	tRNA N-acetyltransferase activity
Sa5Y_RS19855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine