locus-tag	class	description
EN12_RS00015	COG1126	abc transporter atp-binding protein
EN12_RS00020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EN12_RS00025	COG0594	ribonuclease P activity
EN12_RS00035	COG0706	membrane insertase activity
EN12_RS00040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EN12_RS00045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN12_RS00055	COG0445	tRNA wobble uridine modification
EN12_RS00065	COG1192	Involved in chromosome partitioning
EN12_RS00070	COG1475	DNA binding
EN12_RS00075	COG3312	ion transport
EN12_RS00080	COG0356	it plays a direct role in the translocation of protons across the membrane
EN12_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EN12_RS00095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EN12_RS00100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EN12_RS00105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EN12_RS00110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EN12_RS00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EN12_RS00120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EN12_RS00125	COG2814	Major facilitator Superfamily
EN12_RS00130	COG0583	DNA-binding transcription factor activity
EN12_RS00135	COG0183	Belongs to the thiolase family
EN12_RS00145	COG1739	Uncharacterized protein family UPF0029
EN12_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN12_RS00155	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EN12_RS00200	COG0583	DNA-binding transcription factor activity
EN12_RS00205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EN12_RS00210	COG2960	long-chain fatty acid transporting porin activity
EN12_RS00215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN12_RS00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_RS00225	COG1309	transcriptional regulator
EN12_RS00280	COG0747	negative chemotaxis
EN12_RS00285	COG0601	transmembrane transport
EN12_RS00290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN12_RS00300	COG2131	deaminase
EN12_RS00325	COG3621	Patatin-like phospholipase
EN12_RS00365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_RS00370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EN12_RS00380	COG0210	DNA helicase
EN12_RS00385	COG1280	lysine exporter protein (LysE YggA)
EN12_RS00405	COG0514	ATP-dependent DNA helicase (RecQ)
EN12_RS00420	COG1132	(ABC) transporter
EN12_RS00425	COG4774	siderophore transport
EN12_RS00430	COG1120	ATPase activity
EN12_RS00455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN12_RS00460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_RS00460	COG1263	PTS System
EN12_RS00465	COG2862	Uncharacterized protein family, UPF0114
EN12_RS00470	COG1561	YicC-like family, N-terminal region
EN12_RS00475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EN12_RS00480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EN12_RS00485	COG1560	Kdo2-lipid A biosynthetic process
EN12_RS00490	COG1560	Kdo2-lipid A biosynthetic process
EN12_RS00495	COG1309	transcriptional regulator
EN12_RS00500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EN12_RS00510	COG2003	Belongs to the UPF0758 family
EN12_RS00515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EN12_RS00520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EN12_RS00530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EN12_RS00535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EN12_RS00540	COG0859	PFAM glycosyl transferase family 9
EN12_RS00545	COG0463	Glycosyl transferase, family 2
EN12_RS00550	COG0859	PFAM glycosyl transferase family 9
EN12_RS00555	COG3642	lipopolysaccharide core region biosynthetic process
EN12_RS00585	COG1519	Transferase
EN12_RS00620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN12_RS00625	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EN12_RS00625	COG0662	Cupin 2, conserved barrel domain protein
EN12_RS00630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN12_RS00635	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EN12_RS00665	COG0318	PFAM AMP-dependent synthetase and ligase
EN12_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
EN12_RS00670	COG1454	alcohol dehydrogenase
EN12_RS00685	COG5433	transposase activity
EN12_RS00715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN12_RS00720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EN12_RS00725	COG0668	transmembrane transport
EN12_RS00730	COG1573	uracil-dna glycosylase
EN12_RS00740	COG3068	Protein conserved in bacteria
EN12_RS00750	COG1940	carbohydrate kinase activity
EN12_RS00755	COG1253	flavin adenine dinucleotide binding
EN12_RS00765	COG0776	regulation of translation
EN12_RS00775	COG0151	Belongs to the GarS family
EN12_RS00785	COG0789	Transcriptional regulator
EN12_RS00790	COG3710	Transcriptional regulator
EN12_RS00795	COG0531	amino acid
EN12_RS00800	COG1982	Orn Lys Arg decarboxylase major
EN12_RS00805	COG0840	transmembrane signaling receptor activity
EN12_RS00825	COG0800	Aldolase
EN12_RS00835	COG3265	gluconokinase activity
EN12_RS00840	COG0129	dihydroxy-acid dehydratase activity
EN12_RS00845	COG1609	Transcriptional regulator
EN12_RS00850	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EN12_RS00855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN12_RS00860	COG2264	protein methyltransferase activity
EN12_RS00865	COG0439	Biotin carboxylase
EN12_RS00870	COG0511	ligase activity, forming carbon-carbon bonds
EN12_RS00875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EN12_RS00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EN12_RS00900	COG2814	Major facilitator Superfamily
EN12_RS00905	COG0784	Response regulator, receiver
EN12_RS00905	COG2205	protein histidine kinase activity
EN12_RS00910	COG0248	Ppx GppA phosphatase
EN12_RS00915	COG0513	Belongs to the DEAD box helicase family
EN12_RS00920	COG3118	belongs to the thioredoxin family
EN12_RS00935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EN12_RS00980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EN12_RS00995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EN12_RS01005	COG1072	(Pantothenic acid kinase))
EN12_RS01030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN12_RS01035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN12_RS01040	COG0250	Participates in transcription elongation, termination and antitermination
EN12_RS01045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EN12_RS01055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EN12_RS01060	COG0222	ribosome binding
EN12_RS01065	COG0085	RNA polymerase activity
EN12_RS01070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EN12_RS01075	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EN12_RS01080	COG2816	NAD+ diphosphatase activity
EN12_RS01085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EN12_RS01100	COG4942	peptidase
EN12_RS01105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EN12_RS01115	COG0471	metal ion transport
EN12_RS01120	COG0688	phosphatidylethanolamine metabolic process
EN12_RS01125	COG1162	GTPase activity
EN12_RS01130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EN12_RS01175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EN12_RS01180	COG0802	atpase or kinase
EN12_RS01190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EN12_RS01195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EN12_RS01200	COG1923	regulation of RNA biosynthetic process
EN12_RS01205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EN12_RS01210	COG0330	HflC and HflK could
EN12_RS01215	COG0330	HflC and HflK could
EN12_RS01220	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EN12_RS01225	COG2900	Belongs to the SlyX family
EN12_RS01235	COG0545	Peptidyl-prolyl cis-trans isomerase
EN12_RS01240	COG2964	Protein conserved in bacteria
EN12_RS01245	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EN12_RS01250	COG2923	Belongs to the DsrF TusC family
EN12_RS01265	COG0049	tRNA binding
EN12_RS01270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN12_RS01275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN12_RS01280	COG2906	2 iron, 2 sulfur cluster binding
EN12_RS01290	COG0360	Binds together with S18 to 16S ribosomal RNA
EN12_RS01295	COG2965	DNA replication, synthesis of RNA primer
EN12_RS01300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EN12_RS01305	COG0359	binds to the 23S rRNA
EN12_RS01320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN12_RS01325	COG0432	Pfam Uncharacterised protein family UPF0047
EN12_RS01345	COG0735	belongs to the Fur family
EN12_RS01350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN12_RS01375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN12_RS01385	COG0175	sulfate reduction
EN12_RS01425	COG0646	methionine synthase
EN12_RS01425	COG1410	methionine synthase
EN12_RS01430	COG0527	aspartate kinase activity
EN12_RS01435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EN12_RS01445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EN12_RS01460	COG0629	single-stranded DNA binding
EN12_RS01465	COG2200	EAL domain
EN12_RS01465	COG2199	diguanylate cyclase activity
EN12_RS01490	COG3267	Type II secretory pathway component ExeA
EN12_RS01490	COG3409	Peptidoglycan-binding domain 1 protein
EN12_RS01500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_RS01505	COG1459	type II secretion system
EN12_RS01515	COG2165	general secretion pathway protein
EN12_RS01520	COG2165	general secretion pathway protein
EN12_RS01550	COG1077	Cell shape determining protein MreB Mrl
EN12_RS01555	COG1792	Involved in formation and maintenance of cell shape
EN12_RS01560	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EN12_RS01565	COG0424	maF-like protein
EN12_RS01575	COG3164	Protein of unknown function
EN12_RS01580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EN12_RS01585	COG0312	modulator of DNA gyrase
EN12_RS01590	COG2235	arginine
EN12_RS01610	COG0589	response to stress
EN12_RS01620	COG2358	TRAP transporter, solute receptor (TAXI family
EN12_RS01625	COG1438	arginine binding
EN12_RS01630	COG0039	L-malate dehydrogenase activity
EN12_RS01635	COG0531	amino acid
EN12_RS01640	COG0531	amino acid
EN12_RS01645	COG0142	geranyltranstransferase activity
EN12_RS01650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EN12_RS01655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EN12_RS01660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EN12_RS01665	COG2966	Psort location CytoplasmicMembrane, score
EN12_RS01670	COG3610	response to peptide
EN12_RS01680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EN12_RS01685	COG2967	ApaG domain
EN12_RS01690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EN12_RS01695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EN12_RS01700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN12_RS01705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EN12_RS01710	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN12_RS01765	COG0741	lytic transglycosylase activity
EN12_RS01770	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EN12_RS01775	COG1194	a g-specific adenine glycosylase
EN12_RS01785	COG2066	Belongs to the glutaminase family
EN12_RS01790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EN12_RS01795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EN12_RS01805	COG1872	DUF167
EN12_RS01810	COG0762	integral membrane protein
EN12_RS01815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EN12_RS01820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EN12_RS01840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN12_RS01845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EN12_RS01850	COG1678	Uncharacterized ACR, COG1678
EN12_RS01855	COG0189	ligase activity
EN12_RS01860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EN12_RS01865	COG2356	endonuclease I
EN12_RS01875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EN12_RS01885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EN12_RS01890	COG0583	DNA-binding transcription factor activity
EN12_RS01895	COG4771	TonB-dependent receptor
EN12_RS01900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN12_RS01905	COG0126	phosphoglycerate kinase activity
EN12_RS01910	COG0191	fructose-bisphosphate aldolase activity
EN12_RS01920	COG0668	transmembrane transport
EN12_RS01925	COG1279	arginine transmembrane transporter activity
EN12_RS01945	COG1349	DNA-binding transcription factor activity
EN12_RS01950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EN12_RS01955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN12_RS02010	COG4969	Belongs to the N-Me-Phe pilin family
EN12_RS02015	COG0739	heme binding
EN12_RS02050	COG2003	Belongs to the UPF0758 family
EN12_RS02060	COG0840	transmembrane signaling receptor activity
EN12_RS02065	COG2207	Transcriptional regulator
EN12_RS02075	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN12_RS02080	COG0582	viral genome integration into host DNA
EN12_RS02095	COG0358	DNA primase activity
EN12_RS02100	COG1610	YqeY-like protein
EN12_RS02105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EN12_RS02110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EN12_RS02120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EN12_RS02125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EN12_RS02130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN12_RS02135	COG1968	undecaprenyl-diphosphatase activity
EN12_RS02140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EN12_RS02145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EN12_RS02150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EN12_RS02155	COG0585	pseudouridine synthase activity
EN12_RS02160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EN12_RS02165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EN12_RS02175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN12_RS02180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EN12_RS02200	COG4208	sulfate ABC transporter
EN12_RS02205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EN12_RS02215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EN12_RS02225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EN12_RS02235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EN12_RS02285	COG3630	sodium ion export across plasma membrane
EN12_RS02290	COG5016	pyruvate
EN12_RS02290	COG0511	ligase activity, forming carbon-carbon bonds
EN12_RS02295	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN12_RS02305	COG1238	metal cluster binding
EN12_RS02310	COG0612	Peptidase, M16
EN12_RS02315	COG2918	glutathione biosynthetic process
EN12_RS02320	COG1854	S-ribosylhomocysteine lyase activity
EN12_RS02325	COG4536	flavin adenine dinucleotide binding
EN12_RS02330	COG4137	Cytochrome C assembly protein
EN12_RS02335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EN12_RS02340	COG0228	four-way junction DNA binding
EN12_RS02345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EN12_RS02350	COG0336	Belongs to the RNA methyltransferase TrmD family
EN12_RS02355	COG0335	large ribosomal subunit rRNA binding
EN12_RS02360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN12_RS02365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN12_RS02375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EN12_RS02385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EN12_RS02390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EN12_RS02395	COG0723	plastoquinol--plastocyanin reductase activity
EN12_RS02400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EN12_RS02405	COG2857	Cytochrome c1
EN12_RS02410	COG0625	glutathione transferase activity
EN12_RS02415	COG2969	positive regulation of protein catabolic process
EN12_RS02420	COG2823	Periplasmic or secreted lipoprotein
EN12_RS02425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN12_RS02430	COG0792	nuclease activity
EN12_RS02435	COG3107	peptidoglycan biosynthetic process
EN12_RS02440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EN12_RS02455	COG0288	reversible hydration of carbon dioxide
EN12_RS02460	COG0659	secondary active sulfate transmembrane transporter activity
EN12_RS02465	COG1131	(ABC) transporter
EN12_RS02470	COG0842	Transport permease protein
EN12_RS02475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EN12_RS02480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EN12_RS02485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN12_RS02495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN12_RS02505	COG1489	DNA binding
EN12_RS02515	COG1643	Atp-dependent helicase
EN12_RS02520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EN12_RS02525	COG1752	Esterase of the alpha-beta hydrolase superfamily
EN12_RS02530	COG1049	propionate catabolic process, 2-methylcitrate cycle
EN12_RS02535	COG3112	Uncharacterised protein family (UPF0231)
EN12_RS02540	COG0347	Belongs to the P(II) protein family
EN12_RS02545	COG0004	ammonium transporteR
EN12_RS02550	COG1840	ABC-type Fe3 transport system, periplasmic component
EN12_RS02560	COG3842	ATPase activity
EN12_RS02580	COG2971	BadF BadG BcrA BcrD
EN12_RS02590	COG4608	Belongs to the ABC transporter superfamily
EN12_RS02595	COG0444	Belongs to the ABC transporter superfamily
EN12_RS02600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN12_RS02605	COG0601	transmembrane transport
EN12_RS02610	COG0747	negative chemotaxis
EN12_RS02620	COG0784	Response regulator, receiver
EN12_RS02620	COG2205	protein histidine kinase activity
EN12_RS02625	COG2813	Specifically methylates the guanine in position
EN12_RS02630	COG0628	permease
EN12_RS02640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EN12_RS02650	COG0316	Belongs to the HesB IscA family
EN12_RS02665	COG0739	heme binding
EN12_RS02670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN12_RS02675	COG2027	D-alanyl-D-alanine carboxypeptidase
EN12_RS02680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN12_RS02685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN12_RS02690	COG1534	Rna-binding protein
EN12_RS02695	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EN12_RS02700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EN12_RS02705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EN12_RS02715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN12_RS02730	COG0779	Required for maturation of 30S ribosomal subunits
EN12_RS02735	COG0195	Participates in both transcription termination and antitermination
EN12_RS02740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EN12_RS02745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EN12_RS02755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EN12_RS02780	COG0826	peptidase U32
EN12_RS02785	COG0826	peptidase U32
EN12_RS02795	COG3154	lipid carrier protein
EN12_RS02800	COG3153	acetyltransferase
EN12_RS02865	COG4644	lycopene metabolic process
EN12_RS02875	COG3173	Aminoglycoside phosphotransferase
EN12_RS02950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EN12_RS02975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EN12_RS02990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EN12_RS02995	COG1401	restriction endodeoxyribonuclease activity
EN12_RS03040	COG4584	PFAM Integrase catalytic
EN12_RS03055	COG1484	DNA-dependent DNA replication
EN12_RS03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN12_RS03120	COG0681	Belongs to the peptidase S26 family
EN12_RS03160	COG0629	single-stranded DNA binding
EN12_RS03175	COG0714	Associated with various cellular activities
EN12_RS03200	COG2003	Belongs to the UPF0758 family
EN12_RS03315	COG0513	Belongs to the DEAD box helicase family
EN12_RS03330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EN12_RS03335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EN12_RS03340	COG2204	response regulator
EN12_RS03350	COG0667	Aldo Keto reductase
EN12_RS03365	COG0494	nUDIX hydrolase
EN12_RS03370	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EN12_RS03375	COG0730	response to heat
EN12_RS03380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EN12_RS03390	COG1283	sodium-dependent phosphate transmembrane transporter activity
EN12_RS03395	COG0583	DNA-binding transcription factor activity
EN12_RS03400	COG0640	Transcriptional regulator
EN12_RS03405	COG0268	Binds directly to 16S ribosomal RNA
EN12_RS03410	COG0728	peptidoglycan biosynthetic process
EN12_RS03415	COG0196	riboflavin kinase activity
EN12_RS03430	COG1047	Peptidyl-prolyl cis-trans
EN12_RS03435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EN12_RS03440	COG1966	Carbon starvation protein
EN12_RS03455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN12_RS03460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EN12_RS03470	COG3279	Response regulator of the LytR AlgR family
EN12_RS03475	COG3275	phosphorelay sensor kinase activity
EN12_RS03480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN12_RS03485	COG1605	Chorismate mutase
EN12_RS03485	COG0287	Prephenate dehydrogenase
EN12_RS03495	COG0488	(ABC) transporter
EN12_RS03505	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EN12_RS03515	COG5001	Diguanylate cyclase
EN12_RS03520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN12_RS03525	COG1605	Chorismate mutase
EN12_RS03525	COG0077	Prephenate dehydratase
EN12_RS03530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN12_RS03535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_RS03540	COG0564	pseudouridine synthase activity
EN12_RS03550	COG0542	response to heat
EN12_RS03590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EN12_RS03595	COG0826	peptidase U32
EN12_RS03605	COG0745	RESPONSE REGULATOR receiver
EN12_RS03610	COG5002	protein histidine kinase activity
EN12_RS03620	COG0248	Ppx GppA phosphatase
EN12_RS03625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EN12_RS03635	COG0581	inorganic phosphate transmembrane transporter activity
EN12_RS03640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EN12_RS03655	COG3142	Participates in the control of copper homeostasis
EN12_RS03660	COG0450	alkyl hydroperoxide reductase
EN12_RS03665	COG0583	DNA-binding transcription factor activity
EN12_RS03670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EN12_RS03680	COG0517	IMP dehydrogenase activity
EN12_RS03700	COG1862	Preprotein translocase
EN12_RS03705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN12_RS03710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN12_RS03715	COG0483	inositol monophosphate 1-phosphatase activity
EN12_RS03725	COG1959	2 iron, 2 sulfur cluster binding
EN12_RS03730	COG1104	cysteine desulfurase activity
EN12_RS03735	COG0822	iron-sulfur transferase activity
EN12_RS03745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN12_RS03750	COG0443	Heat shock 70 kDa protein
EN12_RS03755	COG0633	Ferredoxin
EN12_RS03760	COG2975	iron-sulfur cluster assembly
EN12_RS03765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN12_RS03770	COG0105	UTP biosynthetic process
EN12_RS03775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EN12_RS03785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EN12_RS03790	COG0124	histidyl-tRNA synthetase
EN12_RS03795	COG2976	Protein conserved in bacteria
EN12_RS03800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_RS03805	COG1160	GTP binding
EN12_RS03820	COG1570	exodeoxyribonuclease VII activity
EN12_RS03825	COG0517	IMP dehydrogenase activity
EN12_RS03825	COG0516	GMP reductase activity
EN12_RS03830	COG0519	Catalyzes the synthesis of GMP from XMP
EN12_RS03830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EN12_RS03840	COG1584	GPR1 FUN34 yaaH family protein
EN12_RS03845	COG1535	isochorismatase
EN12_RS03845	COG3433	isochorismatase activity
EN12_RS03850	COG1021	2,3-dihydroxybenzoate-AMP ligase
EN12_RS03855	COG1169	isochorismate synthase
EN12_RS03860	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_RS03870	COG4592	Periplasmic binding protein
EN12_RS03875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN12_RS03880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN12_RS03885	COG1120	ATPase activity
EN12_RS03895	COG0583	DNA-binding transcription factor activity
EN12_RS03900	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EN12_RS03905	COG1115	amino acid carrier protein
EN12_RS03915	COG0583	DNA-binding transcription factor activity
EN12_RS03930	COG4565	transcriptional regulatory protein
EN12_RS03940	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN12_RS03945	COG0511	ligase activity, forming carbon-carbon bonds
EN12_RS03945	COG5016	pyruvate
EN12_RS03950	COG3630	sodium ion export across plasma membrane
EN12_RS03960	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EN12_RS03970	COG2301	Belongs to the HpcH HpaI aldolase family
EN12_RS03975	COG3051	citrate lyase alpha subunit
EN12_RS03995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN12_RS04000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EN12_RS04005	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EN12_RS04075	COG1012	belongs to the aldehyde dehydrogenase family
EN12_RS04095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EN12_RS04100	COG0840	transmembrane signaling receptor activity
EN12_RS04105	COG3710	Transcriptional regulator
EN12_RS04115	COG2165	general secretion pathway protein
EN12_RS04130	COG4796	Type ii and iii secretion system protein
EN12_RS04150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_RS04155	COG1459	type II secretion system
EN12_RS04165	COG2207	Transcriptional regulator
EN12_RS04170	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EN12_RS04190	COG0739	heme binding
EN12_RS04200	COG3064	Membrane
EN12_RS04210	COG0582	viral genome integration into host DNA
EN12_RS04215	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EN12_RS04220	COG2867	negative regulation of translational initiation
EN12_RS04225	COG2914	Belongs to the UPF0125 (RnfH) family
EN12_RS04230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_RS04235	COG0497	DNA recombination
EN12_RS04240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EN12_RS04245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EN12_RS04250	COG0443	Heat shock 70 kDa protein
EN12_RS04255	COG0484	heat shock protein binding
EN12_RS04290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN12_RS04305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EN12_RS04315	COG0047	phosphoribosylformylglycinamidine synthase activity
EN12_RS04315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EN12_RS04345	COG0442	prolyl-tRNA aminoacylation
EN12_RS04350	COG1720	tRNA m6t6A37 methyltransferase activity
EN12_RS04355	COG0254	rRNA binding
EN12_RS04360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EN12_RS04365	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN12_RS04370	COG1671	Belongs to the UPF0178 family
EN12_RS04380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN12_RS04395	COG3098	single-species biofilm formation
EN12_RS04400	COG0564	pseudouridine synthase activity
EN12_RS04405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EN12_RS04410	COG0142	geranyltranstransferase activity
EN12_RS04415	COG1722	exodeoxyribonuclease VII activity
EN12_RS04420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EN12_RS04430	COG0301	tRNA thio-modification
EN12_RS04430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN12_RS04440	COG0583	DNA-binding transcription factor activity
EN12_RS04445	COG2363	Small membrane protein
EN12_RS04450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_RS04455	COG1611	Belongs to the LOG family
EN12_RS04470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN12_RS04470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN12_RS04480	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EN12_RS04485	COG1464	Belongs to the NlpA lipoprotein family
EN12_RS04490	COG2011	ABC-type metal ion transport system permease component
EN12_RS04495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EN12_RS04500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN12_RS04505	COG1609	Transcriptional regulator
EN12_RS04510	COG1263	PTS System
EN12_RS04510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_RS04515	COG0366	Alpha amylase catalytic
EN12_RS04545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN12_RS04550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN12_RS04555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EN12_RS04560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EN12_RS04565	COG0110	maltose O-acetyltransferase activity
EN12_RS04585	COG1045	serine acetyltransferase
EN12_RS04595	COG0438	transferase activity, transferring glycosyl groups
EN12_RS04605	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EN12_RS04635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN12_RS04645	COG1596	polysaccharide export
EN12_RS04670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EN12_RS04680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EN12_RS04685	COG0321	lipoyl(octanoyl) transferase activity
EN12_RS04690	COG2921	Belongs to the UPF0250 family
EN12_RS04700	COG1686	Belongs to the peptidase S11 family
EN12_RS04705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN12_RS04710	COG0772	Belongs to the SEDS family
EN12_RS04715	COG0768	penicillin binding
EN12_RS04720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EN12_RS04725	COG0799	negative regulation of ribosome biogenesis
EN12_RS04730	COG1466	dna polymerase III delta subunit
EN12_RS04735	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EN12_RS04740	COG0495	leucyl-tRNA aminoacylation
EN12_RS04745	COG2888	peptidyl-tyrosine sulfation
EN12_RS04750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EN12_RS04755	COG4535	Mg2 and Co2 transporter CorC
EN12_RS04765	COG1702	phosphate starvation-inducible protein PhoH
EN12_RS04770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN12_RS04775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_RS04780	COG2190	(PTS) system
EN12_RS04790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_RS04800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EN12_RS04805	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EN12_RS04810	COG3115	cell septum assembly
EN12_RS04815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EN12_RS04830	COG0789	Transcriptional regulator
EN12_RS04835	COG1585	Membrane protein implicated in regulation of membrane protease activity
EN12_RS04840	COG0330	HflC and HflK could
EN12_RS04845	COG3118	belongs to the thioredoxin family
EN12_RS04850	COG0300	oxidoreductase activity
EN12_RS04855	COG1090	epimerase
EN12_RS04860	COG0622	Phosphoesterase
EN12_RS04875	COG3710	Transcriptional regulator
EN12_RS04880	COG0326	Molecular chaperone. Has ATPase activity
EN12_RS04885	COG0563	adenylate kinase activity
EN12_RS04890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EN12_RS04905	COG0367	asparagine synthase
EN12_RS04910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EN12_RS04910	COG4651	solute:proton antiporter activity
EN12_RS04915	COG1940	carbohydrate kinase activity
EN12_RS04915	COG1846	Transcriptional regulator
EN12_RS04920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN12_RS04925	COG1263	PTS System
EN12_RS04925	COG2190	(PTS) system
EN12_RS04925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_RS04940	COG0101	tRNA pseudouridine synthase activity
EN12_RS04945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EN12_RS04950	COG0285	dihydrofolate synthase activity
EN12_RS04955	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EN12_RS04960	COG1286	toxin biosynthetic process
EN12_RS04965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EN12_RS04970	COG2056	Na+-H+ antiporter family
EN12_RS04975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EN12_RS04995	COG0346	lactoylglutathione lyase activity
EN12_RS05000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EN12_RS05020	COG4656	Part of a membrane complex involved in electron transport
EN12_RS05025	COG2878	Part of a membrane complex involved in electron transport
EN12_RS05030	COG4657	Part of a membrane complex involved in electron transport
EN12_RS05040	COG0556	nucleotide-excision repair
EN12_RS05050	COG2204	response regulator
EN12_RS05055	COG2198	Histidine kinase
EN12_RS05060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EN12_RS05065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EN12_RS05070	COG0521	Mo-molybdopterin cofactor biosynthetic process
EN12_RS05075	COG0315	cyclic pyranopterin monophosphate synthase activity
EN12_RS05080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EN12_RS05085	COG0314	molybdopterin synthase activity
EN12_RS05090	COG2199	diguanylate cyclase activity
EN12_RS05095	COG0517	IMP dehydrogenase activity
EN12_RS05095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EN12_RS05095	COG0617	tRNA 3'-terminal CCA addition
EN12_RS05110	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EN12_RS05120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_RS05120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_RS05125	COG0489	protein tyrosine kinase activity
EN12_RS05135	COG0572	uridine kinase
EN12_RS05140	COG2982	Protein involved in outer membrane biogenesis
EN12_RS05145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EN12_RS05150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN12_RS05160	COG2067	long-chain fatty acid transport protein
EN12_RS05180	COG0183	Belongs to the thiolase family
EN12_RS05185	COG1250	3-hydroxyacyl-CoA dehydrogenase
EN12_RS05185	COG1024	Enoyl-CoA hydratase
EN12_RS05190	COG0778	Nitroreductase
EN12_RS05195	COG0583	DNA-binding transcription factor activity
EN12_RS05200	COG0745	RESPONSE REGULATOR receiver
EN12_RS05210	COG2832	Protein of unknown function (DUF454)
EN12_RS05215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EN12_RS05225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EN12_RS05230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EN12_RS05240	COG2983	Belongs to the UPF0260 family
EN12_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_RS05250	COG0616	signal peptide processing
EN12_RS05260	COG1522	sequence-specific DNA binding
EN12_RS05265	COG1946	Acyl-CoA thioesterase
EN12_RS05285	COG3706	GGDEF domain
EN12_RS05290	COG0640	Transcriptional regulator
EN12_RS05295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN12_RS05320	COG1881	PFAM PEBP family protein
EN12_RS05340	COG0009	L-threonylcarbamoyladenylate synthase
EN12_RS05355	COG2201	protein-glutamate methylesterase activity
EN12_RS05365	COG5002	protein histidine kinase activity
EN12_RS05370	COG4191	Histidine kinase
EN12_RS05375	COG3300	MHYT domain
EN12_RS05375	COG5001	Diguanylate cyclase
EN12_RS05380	COG2204	response regulator
EN12_RS05400	COG0601	transmembrane transport
EN12_RS05405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN12_RS05410	COG0444	Belongs to the ABC transporter superfamily
EN12_RS05415	COG4608	Belongs to the ABC transporter superfamily
EN12_RS05420	COG0435	Glutathione S-transferase
EN12_RS05425	COG0857	belongs to the CobB CobQ family
EN12_RS05425	COG0280	phosphate acetyltransferase
EN12_RS05430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EN12_RS05435	COG3092	negative regulation of chromosome organization
EN12_RS05440	COG4628	conserved protein (DUF2132)
EN12_RS05450	COG4120	Belongs to the binding-protein-dependent transport system permease family
EN12_RS05460	COG2199	diguanylate cyclase activity
EN12_RS05460	COG2203	Gaf domain
EN12_RS05465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN12_RS05475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EN12_RS05480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EN12_RS05485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EN12_RS05490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EN12_RS05495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN12_RS05500	COG0156	8-amino-7-oxononanoate synthase activity
EN12_RS05505	COG2226	methyltransferase
EN12_RS05510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EN12_RS05520	COG0501	Belongs to the peptidase M48B family
EN12_RS05530	COG0300	oxidoreductase activity
EN12_RS05545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EN12_RS05555	COG2268	Band 7 protein
EN12_RS05565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EN12_RS05570	COG2915	High frequency lysogenization protein hflD homolog
EN12_RS05575	COG0482	sulfurtransferase activity
EN12_RS05580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN12_RS05590	COG1757	Na H antiporter
EN12_RS05595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EN12_RS05600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EN12_RS05605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EN12_RS05610	COG0131	Imidazoleglycerol-phosphate dehydratase
EN12_RS05610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN12_RS05615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EN12_RS05620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EN12_RS05625	COG0107	imidazoleglycerol-phosphate synthase activity
EN12_RS05630	COG0140	phosphoribosyl-ATP diphosphatase activity
EN12_RS05630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EN12_RS05635	COG1187	pseudouridine synthase activity
EN12_RS05645	COG1278	Cold shock
EN12_RS05650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EN12_RS05655	COG0542	response to heat
EN12_RS05660	COG2985	domain, Protein
EN12_RS05660	COG3273	potassium ion transport
EN12_RS05665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN12_RS05670	COG1454	alcohol dehydrogenase
EN12_RS05670	COG1012	belongs to the aldehyde dehydrogenase family
EN12_RS05675	COG1737	Transcriptional regulator
EN12_RS05680	COG0076	glutamate decarboxylase activity
EN12_RS05690	COG2431	L-lysine efflux transmembrane transporter activity
EN12_RS05700	COG3070	regulator of competence-specific genes
EN12_RS05715	COG3852	Histidine kinase
EN12_RS05725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EN12_RS05740	COG4067	protein conserved in archaea
EN12_RS05740	COG0189	ligase activity
EN12_RS05745	COG0500	methyltransferase
EN12_RS05750	COG4106	trans-aconitate 2-methyltransferase activity
EN12_RS05755	COG1801	Protein of unknown function DUF72
EN12_RS05760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EN12_RS05765	COG1435	thymidine kinase activity
EN12_RS05775	COG0159	tryptophan synthase activity
EN12_RS05780	COG0133	tryptophan synthase activity
EN12_RS05785	COG0135	phosphoribosylanthranilate isomerase activity
EN12_RS05785	COG0134	indole-3-glycerol-phosphate synthase activity
EN12_RS05790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EN12_RS05795	COG0512	Glutamine amidotransferase of anthranilate synthase
EN12_RS05800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN12_RS05810	COG0613	PHP domain protein
EN12_RS05815	COG0009	L-threonylcarbamoyladenylate synthase
EN12_RS05820	COG1187	pseudouridine synthase activity
EN12_RS05825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EN12_RS05830	COG4988	ABC transporter
EN12_RS05835	COG0492	ferredoxin-NADP+ reductase activity
EN12_RS05845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN12_RS05850	COG3706	GGDEF domain
EN12_RS05855	COG2949	membrane
EN12_RS05865	COG0281	malic enzyme
EN12_RS05875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EN12_RS05895	COG2885	chlorophyll binding
EN12_RS05910	COG0277	FAD linked oxidase domain protein
EN12_RS05910	COG0247	lactate metabolic process
EN12_RS05930	COG2986	histidine ammonia-lyase
EN12_RS05935	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EN12_RS05940	COG0010	Belongs to the arginase family
EN12_RS05945	COG1228	amidohydrolase
EN12_RS05960	COG3099	Belongs to the UPF0263 family
EN12_RS05965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN12_RS05975	COG5001	Diguanylate cyclase
EN12_RS05980	COG0417	DNA replication proofreading
EN12_RS05985	COG2197	response regulator
EN12_RS05990	COG0322	excinuclease ABC activity
EN12_RS06030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EN12_RS06035	COG0072	phenylalanine-tRNA ligase activity
EN12_RS06035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_RS06040	COG0776	regulation of translation
EN12_RS06080	COG1346	cytolysis
EN12_RS06085	COG1380	Effector of murein hydrolase LrgA
EN12_RS06090	COG2925	Exonuclease
EN12_RS06095	COG1823	symporter activity
EN12_RS06100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_RS06105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EN12_RS06110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EN12_RS06130	COG4139	cobalamin transport
EN12_RS06180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN12_RS06185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN12_RS06190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN12_RS06200	COG1054	Belongs to the UPF0176 family
EN12_RS06210	COG2814	Major facilitator Superfamily
EN12_RS06220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EN12_RS06250	COG3108	Peptidase M15
EN12_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN12_RS06270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN12_RS06295	COG1846	Transcriptional regulator
EN12_RS06300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EN12_RS06305	COG0726	polysaccharide deacetylase
EN12_RS06310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EN12_RS06320	COG1447	Phosphotransferase system cellobiose-specific component IIA
EN12_RS06325	COG1486	melibiose metabolic process
EN12_RS06335	COG1609	Transcriptional regulator
EN12_RS06340	COG2943	transferase activity, transferring hexosyl groups
EN12_RS06345	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EN12_RS06350	COG0840	transmembrane signaling receptor activity
EN12_RS06365	COG1448	Aminotransferase
EN12_RS06375	COG3437	response regulator, receiver
EN12_RS06375	COG2770	Histidine kinase
EN12_RS06380	COG0351	phosphomethylpyrimidine kinase
EN12_RS06385	COG0017	Asparaginyl-tRNA synthetase
EN12_RS06390	COG0840	transmembrane signaling receptor activity
EN12_RS06395	COG0720	synthase
EN12_RS06400	COG1760	l-serine dehydratase
EN12_RS06405	COG0814	amino acid
EN12_RS06410	COG0494	nUDIX hydrolase
EN12_RS06415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN12_RS06430	COG3106	COG3106 Predicted ATPase
EN12_RS06435	COG3768	UPF0283 membrane protein
EN12_RS06445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN12_RS06460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN12_RS06470	COG0471	metal ion transport
EN12_RS06475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN12_RS06475	COG4191	Histidine kinase
EN12_RS06485	COG2990	Protein conserved in bacteria
EN12_RS06490	COG3713	MltA-interacting MipA family protein
EN12_RS06495	COG2205	protein histidine kinase activity
EN12_RS06500	COG0745	RESPONSE REGULATOR receiver
EN12_RS06535	COG1129	ABC transporter
EN12_RS06575	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EN12_RS06580	COG0372	Belongs to the citrate synthase family
EN12_RS06610	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN12_RS06620	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EN12_RS06630	COG0625	glutathione transferase activity
EN12_RS06635	COG3437	response regulator, receiver
EN12_RS06655	COG3706	GGDEF domain
EN12_RS06660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN12_RS06665	COG1254	Belongs to the acylphosphatase family
EN12_RS06670	COG2920	part of a sulfur-relay system
EN12_RS06675	COG0670	Belongs to the BI1 family
EN12_RS06680	COG1126	abc transporter atp-binding protein
EN12_RS06685	COG0765	amino acid transport
EN12_RS06690	COG4597	amino acid ABC transporter
EN12_RS06695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN12_RS06705	COG0561	phosphatase activity
EN12_RS06710	COG0602	queuosine metabolic process
EN12_RS06715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EN12_RS06745	COG3706	GGDEF domain
EN12_RS06750	COG0443	Heat shock 70 kDa protein
EN12_RS06755	COG0443	Heat shock 70 kDa protein
EN12_RS06795	COG1643	Atp-dependent helicase
EN12_RS06805	COG0443	Heat shock 70 kDa protein
EN12_RS06810	COG0095	Lipoate-protein ligase
EN12_RS06820	COG0583	DNA-binding transcription factor activity
EN12_RS06825	COG0477	Major facilitator Superfamily
EN12_RS06830	COG0415	Belongs to the DNA photolyase family
EN12_RS06845	COG0745	RESPONSE REGULATOR receiver
EN12_RS06855	COG0643	Histidine kinase
EN12_RS06855	COG2198	Histidine kinase
EN12_RS06860	COG2198	Histidine kinase
EN12_RS06860	COG0784	Response regulator, receiver
EN12_RS06860	COG0643	Histidine kinase
EN12_RS06865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN12_RS06875	COG2201	protein-glutamate methylesterase activity
EN12_RS06880	COG0835	chemotaxis
EN12_RS06885	COG3290	protein histidine kinase activity
EN12_RS06885	COG0840	transmembrane signaling receptor activity
EN12_RS06890	COG0840	transmembrane signaling receptor activity
EN12_RS06900	COG0513	Belongs to the DEAD box helicase family
EN12_RS06910	COG1538	Outer membrane efflux protein
EN12_RS06915	COG1566	PFAM secretion protein HlyD family protein
EN12_RS06920	COG2814	Major facilitator Superfamily
EN12_RS06930	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EN12_RS06940	COG3501	Rhs element vgr protein
EN12_RS06950	COG3675	Pfam Lipase (class 3)
EN12_RS06965	COG1280	lysine exporter protein (LysE YggA)
EN12_RS06970	COG1115	amino acid carrier protein
EN12_RS06985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN12_RS06995	COG1177	transmembrane transport
EN12_RS07005	COG3842	ATPase activity
EN12_RS07030	COG0589	response to stress
EN12_RS07035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EN12_RS07050	COG2217	Heavy metal translocating P-type atpase
EN12_RS07060	COG2010	Cytochrome c
EN12_RS07075	COG3278	Belongs to the heme-copper respiratory oxidase family
EN12_RS07090	COG2205	protein histidine kinase activity
EN12_RS07090	COG0784	Response regulator, receiver
EN12_RS07115	COG2994	toxin metabolic process
EN12_RS07120	COG3064	Membrane
EN12_RS07120	COG1073	alpha beta
EN12_RS07120	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN12_RS07135	COG4128	Pfam Zonular occludens toxin
EN12_RS07165	COG1476	TRANSCRIPTIONal
EN12_RS07185	COG1476	TRANSCRIPTIONal
EN12_RS07270	COG3120	sequence-specific DNA binding
EN12_RS07275	COG1067	ATP-dependent peptidase activity
EN12_RS07280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN12_RS07295	COG0488	(ABC) transporter
EN12_RS07305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN12_RS07305	COG0116	Belongs to the methyltransferase superfamily
EN12_RS07315	COG0167	dihydroorotate dehydrogenase activity
EN12_RS07330	COG0308	aminopeptidase N
EN12_RS07345	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EN12_RS07350	COG1956	GAF domain-containing protein
EN12_RS07355	COG1132	(ABC) transporter
EN12_RS07360	COG2995	paraquat-inducible protein a
EN12_RS07365	COG3008	intermembrane lipid transfer
EN12_RS07375	COG2996	Protein conserved in bacteria
EN12_RS07390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN12_RS07395	COG1666	GTP binding
EN12_RS07400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EN12_RS07415	COG0437	4 iron, 4 sulfur cluster binding
EN12_RS07420	COG0243	molybdopterin cofactor binding
EN12_RS07420	COG3383	formate dehydrogenase (NAD+) activity
EN12_RS07450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EN12_RS07455	COG0488	(ABC) transporter
EN12_RS07460	COG3852	Histidine kinase
EN12_RS07465	COG2204	response regulator
EN12_RS07475	COG4662	Binding-protein-dependent transport system inner membrane component
EN12_RS07480	COG3842	ATPase activity
EN12_RS07485	COG0746	molybdenum cofactor guanylyltransferase activity
EN12_RS07515	COG1940	carbohydrate kinase activity
EN12_RS07520	COG3148	PFAM DTW domain containing protein
EN12_RS07530	COG0840	transmembrane signaling receptor activity
EN12_RS07535	COG0791	NLP P60 protein
EN12_RS07545	COG3001	Fructosamine kinase
EN12_RS07555	COG0534	Mate efflux family protein
EN12_RS07565	COG1793	dna ligase
EN12_RS07575	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EN12_RS07580	COG0848	biopolymer transport protein
EN12_RS07585	COG0811	peptide transport
EN12_RS07590	COG0811	peptide transport
EN12_RS07605	COG1175	transmembrane transport
EN12_RS07610	COG0395	ABC-type sugar transport system, permease component
EN12_RS07615	COG3842	ATPase activity
EN12_RS07620	COG1349	DNA-binding transcription factor activity
EN12_RS07625	COG0584	glycerophosphoryl diester phosphodiesterase
EN12_RS07630	COG2731	YhcH YjgK YiaL family protein
EN12_RS07635	COG0251	oxidation-reduction process
EN12_RS07640	COG1609	Transcriptional regulator
EN12_RS07645	COG2723	6-phospho-beta-galactosidase activity
EN12_RS07655	COG0583	DNA-binding transcription factor activity
EN12_RS07675	COG1136	(ABC) transporter
EN12_RS07675	COG0577	efflux transmembrane transporter activity
EN12_RS07680	COG0577	efflux transmembrane transporter activity
EN12_RS07680	COG1136	(ABC) transporter
EN12_RS07685	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN12_RS07685	COG1136	(ABC) transporter
EN12_RS07690	COG1294	oxidase, subunit
EN12_RS07695	COG1271	oxidase subunit
EN12_RS07735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN12_RS07745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EN12_RS07765	COG0753	catalase activity
EN12_RS07795	COG2199	diguanylate cyclase activity
EN12_RS07795	COG2200	EAL domain
EN12_RS07805	COG2017	converts alpha-aldose to the beta-anomer
EN12_RS07810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EN12_RS07815	COG1085	galactose-1-phosphate uridylyltransferase
EN12_RS07855	COG0784	Response regulator, receiver
EN12_RS07855	COG0835	chemotaxis
EN12_RS07865	COG4565	transcriptional regulatory protein
EN12_RS07870	COG3290	protein histidine kinase activity
EN12_RS07885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_RS07905	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EN12_RS07910	COG3063	Type IV pilus biogenesis stability protein PilW
EN12_RS07920	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EN12_RS07925	COG1451	nucleotide metabolic process
EN12_RS07935	COG0583	DNA-binding transcription factor activity
EN12_RS07955	COG1538	Outer membrane efflux protein
EN12_RS07970	COG1748	Saccharopine dehydrogenase
EN12_RS07980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN12_RS07990	COG0577	efflux transmembrane transporter activity
EN12_RS07995	COG4181	ATPase activity
EN12_RS08000	COG0534	Mate efflux family protein
EN12_RS08005	COG0702	epimerase
EN12_RS08015	COG2814	Major facilitator Superfamily
EN12_RS08020	COG1187	pseudouridine synthase activity
EN12_RS08025	COG1061	Type III restriction enzyme res subunit
EN12_RS08045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EN12_RS08050	COG2203	Gaf domain
EN12_RS08050	COG5001	Diguanylate cyclase
EN12_RS08050	COG4251	negative regulation of phosphorylation
EN12_RS08050	COG3706	GGDEF domain
EN12_RS08065	COG0840	transmembrane signaling receptor activity
EN12_RS08095	COG4934	collagen metabolic process
EN12_RS08110	COG0784	Response regulator, receiver
EN12_RS08110	COG2205	protein histidine kinase activity
EN12_RS08115	COG2239	Acts as a magnesium transporter
EN12_RS08125	COG0814	amino acid
EN12_RS08130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_RS08135	COG1131	(ABC) transporter
EN12_RS08140	COG0842	Transport permease protein
EN12_RS08150	COG3313	Fe-S protein
EN12_RS08160	COG4134	Bacterial extracellular solute-binding protein
EN12_RS08165	COG4135	transport system, permease component
EN12_RS08170	COG4136	ATPase activity
EN12_RS08175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EN12_RS08180	COG0564	pseudouridine synthase activity
EN12_RS08185	COG0733	neurotransmitter:sodium symporter activity
EN12_RS08195	COG0626	cystathionine gamma-synthase activity
EN12_RS08200	COG2818	Glycosylase
EN12_RS08215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_RS08230	COG1842	Phage shock protein A
EN12_RS08235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EN12_RS08245	COG4168	peptide transport system, permease
EN12_RS08260	COG4172	Belongs to the ABC transporter superfamily
EN12_RS08275	COG1227	inorganic diphosphatase activity
EN12_RS08295	COG0243	molybdopterin cofactor binding
EN12_RS08300	COG3005	denitrification pathway
EN12_RS08305	COG4459	periplasmic nitrate reductase
EN12_RS08315	COG2116	formate transmembrane transporter activity
EN12_RS08325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN12_RS08330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN12_RS08345	COG1607	acyl-coa hydrolase
EN12_RS08350	COG2350	Protein conserved in bacteria
EN12_RS08360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EN12_RS08365	COG0583	DNA-binding transcription factor activity
EN12_RS08380	COG0612	Peptidase, M16
EN12_RS08385	COG5001	Diguanylate cyclase
EN12_RS08390	COG1032	radical SAM domain protein
EN12_RS08410	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EN12_RS08420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN12_RS08425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN12_RS08430	COG0745	RESPONSE REGULATOR receiver
EN12_RS08435	COG3381	protein complex oligomerization
EN12_RS08440	COG1609	Transcriptional regulator
EN12_RS08445	COG3070	regulator of competence-specific genes
EN12_RS08465	COG0297	glycogen (starch) synthase activity
EN12_RS08470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EN12_RS08475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN12_RS08505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EN12_RS08510	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EN12_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
EN12_RS08540	COG1309	transcriptional regulator
EN12_RS08565	COG0668	transmembrane transport
EN12_RS08570	COG2995	paraquat-inducible protein a
EN12_RS08575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN12_RS08575	COG3008	intermembrane lipid transfer
EN12_RS08585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN12_RS08600	COG0582	viral genome integration into host DNA
EN12_RS08610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EN12_RS08630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EN12_RS08650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EN12_RS08670	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN12_RS08675	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN12_RS08680	COG1737	Transcriptional regulator
EN12_RS08685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EN12_RS08690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN12_RS08695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN12_RS08700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN12_RS08715	COG1940	carbohydrate kinase activity
EN12_RS08720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN12_RS08725	COG4409	exo-alpha-(2->6)-sialidase activity
EN12_RS08735	COG2003	Belongs to the UPF0758 family
EN12_RS08755	COG3941	tape measure
EN12_RS08795	COG0488	(ABC) transporter
EN12_RS08870	COG0415	Belongs to the DNA photolyase family
EN12_RS08880	COG4628	conserved protein (DUF2132)
EN12_RS08885	COG3284	Transcriptional regulator
EN12_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
EN12_RS08900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_RS08905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_RS08910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_RS08920	COG2207	Transcriptional regulator
EN12_RS08925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_RS08925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN12_RS08925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_RS08930	COG1482	cell wall glycoprotein biosynthetic process
EN12_RS08940	COG0784	Response regulator, receiver
EN12_RS08940	COG5002	protein histidine kinase activity
EN12_RS08950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EN12_RS08960	COG2885	chlorophyll binding
EN12_RS08965	COG0823	Involved in the tonB-independent uptake of proteins
EN12_RS08980	COG0811	peptide transport
EN12_RS08985	COG0824	Thioesterase
EN12_RS08990	COG3790	cyd operon protein YbgE
EN12_RS08995	COG4890	Cyd operon protein YbgT
EN12_RS09000	COG1294	oxidase, subunit
EN12_RS09005	COG1271	oxidase subunit
EN12_RS09015	COG0632	four-way junction helicase activity
EN12_RS09020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EN12_RS09025	COG0215	cysteine-tRNA ligase activity
EN12_RS09030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN12_RS09035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_RS09040	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN12_RS09045	COG3012	SEC-C Motif Domain Protein
EN12_RS09050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EN12_RS09055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN12_RS09060	COG1199	ATP-dependent helicase activity
EN12_RS09065	COG0730	response to heat
EN12_RS09070	COG3923	Primosomal replication protein n
EN12_RS09080	COG0840	transmembrane signaling receptor activity
EN12_RS09085	COG0708	Exodeoxyribonuclease III
EN12_RS09090	COG4160	amino acid transport
EN12_RS09115	COG1882	Formate acetyltransferase
EN12_RS09125	COG0840	transmembrane signaling receptor activity
EN12_RS09130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EN12_RS09140	COG3013	Belongs to the UPF0304 family
EN12_RS09145	COG2766	serine protein kinase
EN12_RS09150	COG2718	Belongs to the UPF0229 family
EN12_RS09155	COG2719	SpoVR family
EN12_RS09160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EN12_RS09165	COG2835	tetraacyldisaccharide 4'-kinase activity
EN12_RS09170	COG1663	tetraacyldisaccharide 4'-kinase activity
EN12_RS09175	COG1132	(ABC) transporter
EN12_RS09180	COG0658	competence protein
EN12_RS09180	COG2333	competence protein COMEC
EN12_RS09190	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN12_RS09195	COG1136	(ABC) transporter
EN12_RS09200	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN12_RS09210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EN12_RS09230	COG1252	NADH dehydrogenase
EN12_RS09235	COG3150	esterase
EN12_RS09260	COG0537	adenosine 5'-monophosphoramidase activity
EN12_RS09275	COG2186	Transcriptional regulator
EN12_RS09280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN12_RS09285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EN12_RS09290	COG1674	ftsk spoiiie
EN12_RS09300	COG0686	Belongs to the AlaDH PNT family
EN12_RS09310	COG0583	DNA-binding transcription factor activity
EN12_RS09330	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EN12_RS09335	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EN12_RS09340	COG0776	regulation of translation
EN12_RS09345	COG0539	negative regulation of cytoplasmic translation
EN12_RS09350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EN12_RS09355	COG1555	photosystem II stabilization
EN12_RS09360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN12_RS09365	COG0776	regulation of translation
EN12_RS09370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EN12_RS09375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EN12_RS09385	COG0544	peptidyl-prolyl cis-trans isomerase activity
EN12_RS09395	COG4191	Histidine kinase
EN12_RS09405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN12_RS09410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN12_RS09415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN12_RS09420	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EN12_RS09435	COG5001	Diguanylate cyclase
EN12_RS09435	COG3300	MHYT domain
EN12_RS09445	COG4589	Belongs to the CDS family
EN12_RS09480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EN12_RS09490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_RS09505	COG0243	molybdopterin cofactor binding
EN12_RS09510	COG3005	denitrification pathway
EN12_RS09515	COG3325	Belongs to the glycosyl hydrolase 18 family
EN12_RS09515	COG3469	chitinase activity
EN12_RS09520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN12_RS09530	COG2951	lytic endotransglycosylase activity
EN12_RS09535	COG3100	YcgL domain-containing protein
EN12_RS09540	COG0850	regulation of cytokinetic process
EN12_RS09545	COG2894	cell division
EN12_RS09550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EN12_RS09555	COG3015	lipoprotein NlpE involved in copper resistance
EN12_RS09575	COG0477	Major facilitator Superfamily
EN12_RS09585	COG0840	transmembrane signaling receptor activity
EN12_RS09590	COG1396	sequence-specific DNA binding
EN12_RS09595	COG3135	benzoate transporter
EN12_RS09615	COG0596	Alpha beta hydrolase
EN12_RS09620	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EN12_RS09625	COG1169	isochorismate synthase
EN12_RS09630	COG0436	Aminotransferase
EN12_RS09635	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EN12_RS09640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EN12_RS09660	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EN12_RS09665	COG0318	PFAM AMP-dependent synthetase and ligase
EN12_RS09670	COG0596	Alpha beta hydrolase
EN12_RS09685	COG1214	PFAM Peptidase M22, glycoprotease
EN12_RS09690	COG1199	ATP-dependent helicase activity
EN12_RS09700	COG0788	formyltetrahydrofolate deformylase activity
EN12_RS09705	COG0446	pyridine nucleotide-disulphide oxidoreductase
EN12_RS09705	COG1902	pentaerythritol trinitrate reductase activity
EN12_RS09710	COG0616	signal peptide processing
EN12_RS09715	COG0252	asparaginase activity
EN12_RS09720	COG3139	Protein of unknown function (DUF1315)
EN12_RS09730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_RS09735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN12_RS09740	COG0676	glucose-6-phosphate 1-epimerase activity
EN12_RS09750	COG2226	methyltransferase
EN12_RS09765	COG0835	chemotaxis
EN12_RS09765	COG0784	Response regulator, receiver
EN12_RS09770	COG1940	carbohydrate kinase activity
EN12_RS09780	COG4667	esterase of the alpha-beta hydrolase superfamily
EN12_RS09795	COG0733	neurotransmitter:sodium symporter activity
EN12_RS09800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN12_RS09800	COG1263	PTS System
EN12_RS09805	COG0084	hydrolase, TatD family'
EN12_RS09815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EN12_RS09820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EN12_RS09825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN12_RS09830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN12_RS09835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EN12_RS09840	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_RS09850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EN12_RS09855	COG0416	fatty acid biosynthetic process
EN12_RS09860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EN12_RS09865	COG1399	metal-binding, possibly nucleic acid-binding protein
EN12_RS09870	COG0424	maF-like protein
EN12_RS09875	COG0564	pseudouridine synthase activity
EN12_RS09890	COG1530	ribonuclease E activity
EN12_RS09895	COG0659	secondary active sulfate transmembrane transporter activity
EN12_RS09905	COG1012	belongs to the aldehyde dehydrogenase family
EN12_RS09905	COG1454	alcohol dehydrogenase
EN12_RS09910	COG2095	MarC family integral membrane protein
EN12_RS09915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN12_RS09920	COG1757	Na H antiporter
EN12_RS09930	COG3081	Nucleoid-associated protein
EN12_RS09935	COG3082	Protein of unknown function (DUF1414)
EN12_RS09940	COG3083	sulfuric ester hydrolase activity
EN12_RS09960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN12_RS09965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EN12_RS09985	COG2853	Lipoprotein
EN12_RS09995	COG4235	cytochrome complex assembly
EN12_RS09995	COG3088	subunit of a heme lyase
EN12_RS10000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EN12_RS10005	COG1138	Cytochrome C-type biogenesis protein
EN12_RS10010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EN12_RS10020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN12_RS10025	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN12_RS10030	COG4133	protoheme IX ABC transporter activity
EN12_RS10040	COG0835	chemotaxis
EN12_RS10050	COG1192	Involved in chromosome partitioning
EN12_RS10055	COG2201	protein-glutamate methylesterase activity
EN12_RS10060	COG2198	Histidine kinase
EN12_RS10060	COG0643	Histidine kinase
EN12_RS10060	COG0784	Response regulator, receiver
EN12_RS10065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EN12_RS10095	COG2062	phosphohistidine phosphatase, SixA
EN12_RS10100	COG1025	Belongs to the peptidase M16 family
EN12_RS10110	COG0018	arginyl-trna synthetase
EN12_RS10130	COG1918	ferrous iron import across plasma membrane
EN12_RS10135	COG4977	sequence-specific DNA binding
EN12_RS10140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EN12_RS10145	COG1121	(ABC) transporter
EN12_RS10150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EN12_RS10160	COG0045	succinate-CoA ligase (ADP-forming) activity
EN12_RS10165	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN12_RS10170	COG0567	Dehydrogenase, E1 component
EN12_RS10180	COG1053	succinate dehydrogenase
EN12_RS10185	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EN12_RS10190	COG2009	succinate dehydrogenase
EN12_RS10195	COG0372	Belongs to the citrate synthase family
EN12_RS10200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EN12_RS10210	COG0033	Phosphoglucomutase
EN12_RS10215	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EN12_RS10220	COG0596	Alpha beta hydrolase
EN12_RS10235	COG1346	cytolysis
EN12_RS10245	COG0583	DNA-binding transcription factor activity
EN12_RS10255	COG0735	belongs to the Fur family
EN12_RS10260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN12_RS10265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN12_RS10270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN12_RS10280	COG0431	NADPH-dependent FMN reductase
EN12_RS10290	COG3101	peptidyl-lysine hydroxylation
EN12_RS10295	COG2860	membrane
EN12_RS10300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EN12_RS10310	COG2890	protein-(glutamine-N5) methyltransferase activity
EN12_RS10315	COG2840	Smr protein MutS2
EN12_RS10325	COG1684	flagellar biosynthetic protein fliR
EN12_RS10330	COG1987	bacterial-type flagellum assembly
EN12_RS10355	COG1580	Controls the rotational direction of flagella during chemotaxis
EN12_RS10375	COG1317	bacterial-type flagellum organization
EN12_RS10380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EN12_RS10390	COG1677	Flagellar hook-basal body complex protein FliE
EN12_RS10410	COG1516	flagellar protein fliS
EN12_RS10420	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EN12_RS10425	COG1334	flagellar protein FlaG
EN12_RS10430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_RS10435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_RS10440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_RS10445	COG2837	iron assimilation
EN12_RS10465	COG1393	Belongs to the ArsC family
EN12_RS10475	COG1876	peptidase activity
EN12_RS10485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EN12_RS10500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EN12_RS10520	COG4783	chaperone-mediated protein folding
EN12_RS10525	COG1393	Belongs to the ArsC family
EN12_RS10545	COG2233	PERMEase
EN12_RS10550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EN12_RS10555	COG0737	Belongs to the 5'-nucleotidase family
EN12_RS10560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EN12_RS10565	COG2912	Transglutaminase-like superfamily
EN12_RS10575	COG2890	protein-(glutamine-N5) methyltransferase activity
EN12_RS10580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EN12_RS10585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EN12_RS10590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EN12_RS10595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EN12_RS10600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EN12_RS10605	COG0193	aminoacyl-tRNA hydrolase activity
EN12_RS10610	COG0012	GTP binding
EN12_RS10695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_RS10700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN12_RS10720	COG3951	Flagellar rod assembly protein muramidase FlgJ
EN12_RS10720	COG1705	Flagellar rod assembly protein muramidase FlgJ
EN12_RS10725	COG1706	bacterial-type flagellum-dependent cell motility
EN12_RS10730	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EN12_RS10740	COG4787	bacterial-type flagellum-dependent cell motility
EN12_RS10745	COG1749	Flagellar hook protein flgE
EN12_RS10760	COG1815	bacterial-type flagellum-dependent cell motility
EN12_RS10765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN12_RS10770	COG0835	chemotaxis
EN12_RS10770	COG0784	Response regulator, receiver
EN12_RS10805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN12_RS10805	COG3433	isochorismatase activity
EN12_RS10805	COG2226	methyltransferase
EN12_RS10810	COG2375	cellular response to nickel ion
EN12_RS10815	COG1629	transport
EN12_RS10815	COG4774	siderophore transport
EN12_RS10830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN12_RS10835	COG2217	Heavy metal translocating P-type atpase
EN12_RS10835	COG2608	mercury ion transmembrane transporter activity
EN12_RS10850	COG3735	TraB family
EN12_RS10865	COG2840	Smr protein MutS2
EN12_RS10870	COG1187	pseudouridine synthase activity
EN12_RS10880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EN12_RS10885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EN12_RS10890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EN12_RS10895	COG0121	glutamine amidotransferase
EN12_RS10900	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN12_RS10905	COG1960	acyl-CoA dehydrogenase activity
EN12_RS10920	COG0328	RNA-DNA hybrid ribonuclease activity
EN12_RS10925	COG2226	methyltransferase
EN12_RS10930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN12_RS10935	COG1388	LysM domain
EN12_RS10935	COG0741	lytic transglycosylase activity
EN12_RS10940	COG3021	interspecies interaction between organisms
EN12_RS10945	COG0347	Belongs to the P(II) protein family
EN12_RS10950	COG3479	Phenolic acid decarboxylase
EN12_RS10960	COG0037	tRNA processing
EN12_RS10965	COG0825	malonyl-CoA metabolic process
EN12_RS10970	COG0587	DNA-directed DNA polymerase activity
EN12_RS10975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EN12_RS10980	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_RS10985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_RS10990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN12_RS10995	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN12_RS11000	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EN12_RS11010	COG0750	zinc metalloprotease
EN12_RS11015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EN12_RS11020	COG0575	Belongs to the CDS family
EN12_RS11025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EN12_RS11030	COG0233	cytoplasmic translational termination
EN12_RS11035	COG0528	UMP kinase activity
EN12_RS11040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EN12_RS11045	COG0052	Belongs to the universal ribosomal protein uS2 family
EN12_RS11050	COG0024	Methionine aminopeptidase
EN12_RS11055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EN12_RS11065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EN12_RS11070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EN12_RS11075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN12_RS11080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EN12_RS11095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN12_RS11095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN12_RS11100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EN12_RS11105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EN12_RS11110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EN12_RS11120	COG1073	alpha beta
EN12_RS11125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EN12_RS11130	COG2252	PERMEase
EN12_RS11135	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN12_RS11140	COG4067	protein conserved in archaea
EN12_RS11140	COG0189	ligase activity
EN12_RS11145	COG0189	ligase activity
EN12_RS11155	COG0733	neurotransmitter:sodium symporter activity
EN12_RS11160	COG3706	GGDEF domain
EN12_RS11165	COG3328	transposase activity
EN12_RS11195	COG1477	protein flavinylation
EN12_RS11200	COG2871	sodium ion transport
EN12_RS11205	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_RS11210	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_RS11215	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_RS11220	COG1805	sodium ion transport
EN12_RS11225	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN12_RS11230	COG0271	Belongs to the BolA IbaG family
EN12_RS11235	COG2813	Specifically methylates the guanine in position
EN12_RS11245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN12_RS11250	COG2211	Major facilitator Superfamily
EN12_RS11260	COG1595	DNA-templated transcription, initiation
EN12_RS11270	COG3248	Nucleoside-binding outer membrane protein
EN12_RS11275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EN12_RS11280	COG0693	protein deglycase activity
EN12_RS11285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN12_RS11290	COG2166	iron-sulfur cluster assembly
EN12_RS11295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EN12_RS11300	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EN12_RS11310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EN12_RS11310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN12_RS11325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EN12_RS11330	COG1074	ATP-dependent DNA helicase activity
EN12_RS11335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EN12_RS11350	COG3141	response to X-ray
EN12_RS11355	COG2171	N-acyltransferase activity
EN12_RS11365	COG0456	acetyltransferase
EN12_RS11370	COG0569	domain protein
EN12_RS11370	COG0189	ligase activity
EN12_RS11385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN12_RS11390	COG1609	Transcriptional regulator
EN12_RS11395	COG3250	beta-galactosidase activity
EN12_RS11410	COG1022	Amp-dependent synthetase and ligase
EN12_RS11415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN12_RS11420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EN12_RS11430	COG0560	Phosphoserine phosphatase
EN12_RS11440	COG0813	purine-nucleoside phosphorylase activity
EN12_RS11445	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EN12_RS11450	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EN12_RS11455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EN12_RS11465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN12_RS11470	COG0084	hydrolase, TatD family'
EN12_RS11475	COG3022	response to hydroperoxide
EN12_RS11480	COG1115	amino acid carrier protein
EN12_RS11495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EN12_RS11500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EN12_RS11505	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EN12_RS11510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EN12_RS11530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN12_RS11540	COG0745	RESPONSE REGULATOR receiver
EN12_RS11545	COG2198	Histidine kinase
EN12_RS11545	COG0784	Response regulator, receiver
EN12_RS11545	COG5002	protein histidine kinase activity
EN12_RS11550	COG2203	Gaf domain
EN12_RS11550	COG4251	negative regulation of phosphorylation
EN12_RS11550	COG3706	GGDEF domain
EN12_RS11550	COG5001	Diguanylate cyclase
EN12_RS11555	COG1242	4 iron, 4 sulfur cluster binding
EN12_RS11560	COG0067	glutamate synthase
EN12_RS11560	COG0069	glutamate synthase activity
EN12_RS11560	COG0070	glutamate synthase
EN12_RS11570	COG0067	glutamate synthase
EN12_RS11570	COG0070	glutamate synthase
EN12_RS11570	COG0069	glutamate synthase activity
EN12_RS11575	COG0493	'glutamate synthase
EN12_RS11585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EN12_RS11595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EN12_RS11600	COG2860	membrane
EN12_RS11605	COG0583	DNA-binding transcription factor activity
EN12_RS11610	COG0730	response to heat
EN12_RS11640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EN12_RS11645	COG0505	Belongs to the CarA family
EN12_RS11655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EN12_RS11660	COG0494	nUDIX hydrolase
EN12_RS11670	COG0653	protein targeting
EN12_RS11680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EN12_RS11685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EN12_RS11690	COG0849	cell division
EN12_RS11695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EN12_RS11700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN12_RS11710	COG0772	Belongs to the SEDS family
EN12_RS11715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EN12_RS11725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EN12_RS11730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EN12_RS11735	COG0768	penicillin binding
EN12_RS11740	COG3116	cell division
EN12_RS11750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_RS11755	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN12_RS11760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EN12_RS11765	COG2186	Transcriptional regulator
EN12_RS11770	COG0737	Belongs to the 5'-nucleotidase family
EN12_RS11775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EN12_RS11780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN12_RS11785	COG4974	Belongs to the 'phage' integrase family
EN12_RS11790	COG0716	FMN binding
EN12_RS11810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_RS11815	COG1459	type II secretion system
EN12_RS11825	COG0237	dephospho-CoA kinase activity
EN12_RS11830	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EN12_RS11840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EN12_RS11845	COG0187	DNA topoisomerase II activity
EN12_RS11850	COG3150	esterase
EN12_RS11860	COG3151	Protein conserved in bacteria
EN12_RS11865	COG0494	nUDIX hydrolase
EN12_RS11870	COG1538	Outer membrane efflux protein
EN12_RS11880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EN12_RS11885	COG0840	transmembrane signaling receptor activity
EN12_RS11890	COG3025	triphosphatase activity
EN12_RS11895	COG1392	Phosphate transport regulator
EN12_RS11900	COG0306	phosphate transporter
EN12_RS11905	COG4991	sh3 domain protein
EN12_RS11915	COG3267	Type II secretory pathway component ExeA
EN12_RS11915	COG3409	Peptidoglycan-binding domain 1 protein
EN12_RS11925	COG0148	phosphopyruvate hydratase activity
EN12_RS11930	COG0504	CTP synthase activity
EN12_RS11935	COG3956	TIGRFAM MazG family protein
EN12_RS11940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN12_RS11955	COG5001	Diguanylate cyclase
EN12_RS11975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EN12_RS11980	COG1381	Involved in DNA repair and RecF pathway recombination
EN12_RS11985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EN12_RS12000	COG0481	GTPase activity
EN12_RS12005	COG3086	response to oxidative stress
EN12_RS12020	COG1595	DNA-templated transcription, initiation
EN12_RS12030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EN12_RS12040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EN12_RS12055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_RS12060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN12_RS12065	COG3079	Belongs to the UPF0149 family
EN12_RS12070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EN12_RS12075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EN12_RS12080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EN12_RS12085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN12_RS12090	COG0440	acetolactate synthase activity
EN12_RS12095	COG0028	Belongs to the TPP enzyme family
EN12_RS12100	COG1022	Amp-dependent synthetase and ligase
EN12_RS12105	COG0583	DNA-binding transcription factor activity
EN12_RS12130	COG0473	3-isopropylmalate dehydrogenase activity
EN12_RS12135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EN12_RS12140	COG0066	3-isopropylmalate dehydratase activity
EN12_RS12185	COG3437	response regulator, receiver
EN12_RS12200	COG0795	lipopolysaccharide-transporting ATPase activity
EN12_RS12205	COG0795	lipopolysaccharide-transporting ATPase activity
EN12_RS12210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN12_RS12215	COG2927	DNA polymerase III (CHI subunit)
EN12_RS12220	COG0525	valine-tRNA ligase activity
EN12_RS12225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EN12_RS12230	COG0564	pseudouridine synthase activity
EN12_RS12245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EN12_RS12260	COG0540	Belongs to the ATCase OTCase family
EN12_RS12270	COG0251	oxidation-reduction process
EN12_RS12280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EN12_RS12285	COG5007	Belongs to the BolA IbaG family
EN12_RS12295	COG2854	intermembrane phospholipid transfer
EN12_RS12300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN12_RS12305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EN12_RS12310	COG1127	ABC transporter
EN12_RS12325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EN12_RS12325	COG0517	IMP dehydrogenase activity
EN12_RS12340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EN12_RS12345	COG1137	ATPase activity
EN12_RS12355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN12_RS12360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_RS12365	COG1660	Displays ATPase and GTPase activities
EN12_RS12370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN12_RS12375	COG2239	Acts as a magnesium transporter
EN12_RS12380	COG0312	modulator of DNA gyrase
EN12_RS12385	COG3028	Belongs to the UPF0307 family
EN12_RS12390	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EN12_RS12395	COG1178	ABC-type Fe3 transport system permease component
EN12_RS12405	COG0163	prenyltransferase activity
EN12_RS12410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN12_RS12425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EN12_RS12430	COG2105	PFAM AIG2 family protein
EN12_RS12440	COG0729	surface antigen
EN12_RS12445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN12_RS12450	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EN12_RS12465	COG1136	(ABC) transporter
EN12_RS12485	COG0529	Catalyzes the synthesis of activated sulfate
EN12_RS12500	COG1648	precorrin-2 dehydrogenase activity
EN12_RS12500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EN12_RS12505	COG0737	Belongs to the 5'-nucleotidase family
EN12_RS12515	COG0513	Belongs to the DEAD box helicase family
EN12_RS12520	COG2153	protein acetylation
EN12_RS12525	COG0697	spore germination
EN12_RS12530	COG3061	Opacity-associated protein A
EN12_RS12530	COG3266	domain, Protein
EN12_RS12535	COG0545	Peptidyl-prolyl cis-trans isomerase
EN12_RS12545	COG0203	ribosomal protein L17
EN12_RS12550	COG0202	RNA polymerase activity
EN12_RS12555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EN12_RS12560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EN12_RS12565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EN12_RS12570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EN12_RS12575	COG0201	protein transport
EN12_RS12585	COG1841	ribosomal large subunit assembly
EN12_RS12590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EN12_RS12595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EN12_RS12605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EN12_RS12610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EN12_RS12615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EN12_RS12620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EN12_RS12625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EN12_RS12630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EN12_RS12635	COG0255	Belongs to the universal ribosomal protein uL29 family
EN12_RS12640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EN12_RS12645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EN12_RS12650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EN12_RS12655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EN12_RS12660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EN12_RS12665	COG0089	rRNA binding
EN12_RS12670	COG0088	Forms part of the polypeptide exit tunnel
EN12_RS12675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EN12_RS12680	COG0051	transcription antitermination factor activity, RNA binding
EN12_RS12685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN12_RS12690	COG0557	exoribonuclease II activity
EN12_RS12695	COG3083	sulfuric ester hydrolase activity
EN12_RS12700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EN12_RS12715	COG1047	Peptidyl-prolyl cis-trans
EN12_RS12730	COG2249	NAD(P)H dehydrogenase (quinone) activity
EN12_RS12735	COG0488	(ABC) transporter
EN12_RS12745	COG0429	hydrolase of the alpha beta-hydrolase fold
EN12_RS12755	COG3954	Phosphoribulokinase
EN12_RS12770	COG1012	belongs to the aldehyde dehydrogenase family
EN12_RS12780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EN12_RS12790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN12_RS12805	COG0180	Tryptophanyl-tRNA synthetase
EN12_RS12810	COG0546	phosphoglycolate phosphatase activity
EN12_RS12815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EN12_RS12820	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EN12_RS12830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EN12_RS12835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EN12_RS12865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EN12_RS12875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN12_RS12875	COG0678	peroxiredoxin activity
EN12_RS12880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_RS12890	COG0165	Argininosuccinate lyase
EN12_RS12895	COG0137	argininosuccinate synthase activity
EN12_RS12900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN12_RS12905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EN12_RS12910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EN12_RS12915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EN12_RS12925	COG1045	serine acetyltransferase
EN12_RS12930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EN12_RS12935	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EN12_RS12940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN12_RS12945	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EN12_RS12950	COG1053	succinate dehydrogenase
EN12_RS12955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EN12_RS12960	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EN12_RS12970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN12_RS12975	COG1509	lysine 2,3-aminomutase activity
EN12_RS12985	COG0459	protein refolding
EN12_RS12990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EN12_RS13015	COG0149	triose-phosphate isomerase activity
EN12_RS13020	COG0534	Mate efflux family protein
EN12_RS13025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN12_RS13030	COG1575	Belongs to the MenA family. Type 1 subfamily
EN12_RS13035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EN12_RS13040	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EN12_RS13045	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN12_RS13050	COG1609	Transcriptional regulator
EN12_RS13055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EN12_RS13060	COG0254	rRNA binding
EN12_RS13065	COG0281	malic enzyme
EN12_RS13070	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EN12_RS13075	COG0626	cystathionine gamma-synthase activity
EN12_RS13080	COG0460	homoserine dehydrogenase
EN12_RS13080	COG0527	aspartate kinase activity
EN12_RS13085	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EN12_RS13090	COG3074	FtsZ-dependent cytokinesis
EN12_RS13095	COG1494	fructose-1,6-bisphosphatase
EN12_RS13100	COG0205	6-phosphofructokinase activity
EN12_RS13105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EN12_RS13115	COG0745	RESPONSE REGULATOR receiver
EN12_RS13120	COG2205	protein histidine kinase activity
EN12_RS13130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EN12_RS13135	COG3030	protein affecting phage T7 exclusion by the F plasmid
EN12_RS13140	COG3706	GGDEF domain
EN12_RS13145	COG1027	Aspartate ammonia-lyase
EN12_RS13150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EN12_RS13165	COG4232	protein-disulfide reductase activity
EN12_RS13185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EN12_RS13190	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EN12_RS13195	COG0194	GDP metabolic process
EN12_RS13200	COG1758	RNA polymerase activity
EN12_RS13205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN12_RS13210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EN12_RS13215	COG2233	PERMEase
EN12_RS13230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN12_RS13235	COG2183	response to ionizing radiation
EN12_RS13245	COG0596	Alpha beta hydrolase
EN12_RS13250	COG1040	competence protein
EN12_RS13260	COG0494	nUDIX hydrolase
EN12_RS13265	COG1218	3'(2'),5'-bisphosphate nucleotidase
EN12_RS13275	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN12_RS13280	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN12_RS13285	COG3156	type II secretion system protein K
EN12_RS13290	COG4795	General secretion pathway protein
EN12_RS13295	COG2165	general secretion pathway protein
EN12_RS13300	COG2165	general secretion pathway protein
EN12_RS13305	COG2165	general secretion pathway protein
EN12_RS13310	COG1459	type II secretion system
EN12_RS13315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN12_RS13325	COG3031	protein transport across the cell outer membrane
EN12_RS13330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EN12_RS13335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EN12_RS13340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EN12_RS13350	COG0456	acetyltransferase
EN12_RS13355	COG1490	D-aminoacyl-tRNA deacylase activity
EN12_RS13360	COG1295	ribonuclease BN
EN12_RS13370	COG1217	gtp-binding protein TYPA
EN12_RS13380	COG0174	glutamine synthetase
EN12_RS13390	COG3852	Histidine kinase
EN12_RS13400	COG5001	Diguanylate cyclase
EN12_RS13400	COG3300	MHYT domain
EN12_RS13405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EN12_RS13440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EN12_RS13445	COG1404	Belongs to the peptidase S8 family
EN12_RS13450	COG4206	TonB-dependent receptor
EN12_RS13455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN12_RS13470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN12_RS13475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN12_RS13480	COG2177	Part of the ABC transporter FtsEX involved in
EN12_RS13485	COG2884	Cell division ATP-binding protein ftsE
EN12_RS13490	COG0552	protein localization to endoplasmic reticulum
EN12_RS13495	COG0742	ribosomal rna small subunit methyltransferase
EN12_RS13530	COG0783	Belongs to the Dps family
EN12_RS13535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN12_RS13540	COG1280	lysine exporter protein (LysE YggA)
EN12_RS13545	COG2267	carboxylic ester hydrolase activity
EN12_RS13550	COG0561	phosphatase activity
EN12_RS13570	COG2199	diguanylate cyclase activity
EN12_RS13570	COG2200	EAL domain
EN12_RS13570	COG3287	FIST C domain
EN12_RS13575	COG1011	Hydrolase
EN12_RS13580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EN12_RS13590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EN12_RS13595	COG0019	diaminopimelate decarboxylase activity
EN12_RS13605	COG1965	Belongs to the frataxin family
EN12_RS13620	COG0181	hydroxymethylbilane synthase activity
EN12_RS13625	COG1587	Uroporphyrinogen-III synthase
EN12_RS13630	COG2959	enzyme of heme biosynthesis
EN12_RS13635	COG3071	HemY protein
EN12_RS13650	COG3078	GTPase activator activity
EN12_RS13670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_RS13670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN12_RS13685	COG0084	hydrolase, TatD family'
EN12_RS13695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN12_RS13705	COG0840	transmembrane signaling receptor activity
EN12_RS13710	COG1580	Controls the rotational direction of flagella during chemotaxis
EN12_RS13720	COG3161	chorismate lyase activity
EN12_RS13725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EN12_RS13735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EN12_RS13745	COG0534	Mate efflux family protein
EN12_RS13750	COG1858	cytochrome C peroxidase
EN12_RS13755	COG0805	protein transport
EN12_RS13760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN12_RS13765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN12_RS13780	COG2226	methyltransferase
EN12_RS13785	COG1322	Protein conserved in bacteria
EN12_RS13795	COG2081	HI0933 family
EN12_RS13805	COG1528	Iron-storage protein
EN12_RS13815	COG0589	response to stress
EN12_RS13835	COG5002	protein histidine kinase activity
EN12_RS13835	COG5001	Diguanylate cyclase
EN12_RS13840	COG1522	sequence-specific DNA binding
EN12_RS13860	COG0006	proline dipeptidase activity
EN12_RS13860	COG0006	proline dipeptidase activity
EN12_RS13865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN12_RS13870	COG2022	thiamine diphosphate biosynthetic process
EN12_RS13875	COG2104	thiamine diphosphate biosynthetic process
EN12_RS13880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EN12_RS13890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EN12_RS13895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EN12_RS13940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EN12_RS13950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EN12_RS13955	COG0408	coproporphyrinogen oxidase activity
EN12_RS13960	COG0009	L-threonylcarbamoyladenylate synthase
EN12_RS13965	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EN12_RS13970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EN12_RS13975	COG0551	DNA topoisomerase type I activity
EN12_RS13980	COG2922	Belongs to the Smg family
EN12_RS13985	COG0758	DNA mediated transformation
EN12_RS13990	COG1652	LysM domain
EN12_RS13995	COG0242	peptide deformylase activity
EN12_RS14000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EN12_RS14005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN12_RS14005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EN12_RS14010	COG0569	domain protein
EN12_RS14015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN12_RS14025	COG1272	protein, Hemolysin III
EN12_RS14030	COG4326	sporulation control protein
EN12_RS14040	COG3084	Protein conserved in bacteria
EN12_RS14050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EN12_RS14055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN12_RS14060	COG0204	Acyl-transferase
EN12_RS14065	COG0606	chelatase, subunit chli
EN12_RS14080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN12_RS14085	COG0129	dihydroxy-acid dehydratase activity
EN12_RS14095	COG0604	alcohol dehydrogenase
EN12_RS14105	COG0425	Belongs to the sulfur carrier protein TusA family
EN12_RS14115	COG2119	membrane
EN12_RS14120	COG0752	glycyl-tRNA synthetase alpha subunit
EN12_RS14125	COG0751	glycine-tRNA ligase activity
EN12_RS14130	COG3977	Valine--pyruvate aminotransferase
EN12_RS14135	COG0071	Belongs to the small heat shock protein (HSP20) family
EN12_RS14150	COG0187	DNA topoisomerase II activity
EN12_RS14155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EN12_RS14160	COG0592	DNA-directed DNA polymerase activity
EN12_RS14165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EN12_RS14240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EN12_RS14265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN12_RS14560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EN12_RS14920	COG0439	Biotin carboxylase
EN12_RS15070	COG1072	(Pantothenic acid kinase))
EN12_RS15130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EN12_RS15160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EN12_RS15175	COG0471	metal ion transport
EN12_RS15175	COG0490	domain, Protein
EN12_RS15405	COG1410	methionine synthase
EN12_RS15405	COG0646	methionine synthase
EN12_RS15410	COG0646	methionine synthase
EN12_RS15410	COG1410	methionine synthase
EN12_RS15460	COG2199	diguanylate cyclase activity
EN12_RS15460	COG2200	EAL domain
EN12_RS15615	COG1530	ribonuclease E activity
EN12_RS15755	COG0039	L-malate dehydrogenase activity
EN12_RS15805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EN12_RS16425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EN12_RS16605	COG3107	peptidoglycan biosynthetic process
EN12_RS16685	COG1643	Atp-dependent helicase
EN12_RS16940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN12_RS17115	COG3173	Aminoglycoside phosphotransferase
EN12_RS17370	COG0714	Associated with various cellular activities
EN12_RS17535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EN12_RS17680	COG1472	Belongs to the glycosyl hydrolase 3 family
EN12_RS17725	COG5001	Diguanylate cyclase
EN12_RS17840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EN12_RS18160	COG2301	Belongs to the HpcH HpaI aldolase family
EN12_RS18355	COG4796	Type ii and iii secretion system protein
EN12_RS18430	COG3064	Membrane
EN12_RS18470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN12_RS18480	COG0497	DNA recombination
EN12_RS18550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EN12_RS18550	COG0047	phosphoribosylformylglycinamidine synthase activity
EN12_RS18565	COG0442	prolyl-tRNA aminoacylation
EN12_RS18625	COG0583	DNA-binding transcription factor activity
EN12_RS19035	COG3710	Transcriptional regulator
EN12_RS19575	COG1560	Kdo2-lipid A biosynthetic process
EN12_RS19880	COG0138	bifunctional purine biosynthesis protein purh
EN12_RS19895	COG3710	Transcriptional regulator
EN12_RS20040	COG0784	Response regulator, receiver
EN12_RS20040	COG2198	Histidine kinase
EN12_RS20040	COG2205	protein histidine kinase activity
EN12_RS20090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EN12_RS20170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN12_RS20195	COG0085	RNA polymerase activity
EN12_RS20205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EN12_RS20300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EN12_RS20315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EN12_RS20515	COG0646	methionine synthase
EN12_RS20515	COG1410	methionine synthase
EN12_RS21010	COG1438	arginine binding
EN12_RS21215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EN12_RS21650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EN12_RS21735	COG4536	flavin adenine dinucleotide binding
EN12_RS21755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EN12_RS21830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EN12_RS21840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EN12_RS21850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EN12_RS21990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EN12_RS22075	COG3842	ATPase activity
EN12_RS22245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN12_RS22260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EN12_RS22315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EN12_RS22350	COG0826	peptidase U32
EN12_RS22385	COG5001	Diguanylate cyclase
EN12_RS22680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EN12_RS22760	COG4584	PFAM Integrase catalytic
EN12_RS23140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EN12_RS23190	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EN12_RS23245	COG0196	riboflavin kinase activity
EN12_RS23300	COG1966	Carbon starvation protein
EN12_RS23400	COG5001	Diguanylate cyclase
EN12_RS23405	COG5001	Diguanylate cyclase
EN12_RS23705	COG0443	Heat shock 70 kDa protein
EN12_RS23845	COG1535	isochorismatase
EN12_RS23845	COG3433	isochorismatase activity
EN12_RS23860	COG1021	2,3-dihydroxybenzoate-AMP ligase
EN12_RS23870	COG1169	isochorismate synthase
EN12_RS23880	COG1028	Short-chain dehydrogenase reductase Sdr
EN12_RS23935	COG0583	DNA-binding transcription factor activity
EN12_RS24330	COG4796	Type ii and iii secretion system protein
EN12_RS24380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EN12_RS24425	COG3064	Membrane
EN12_RS24500	COG0497	DNA recombination