locus-tag	class	description
V060002_RS00010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V060002_RS00155	COG4974	Belongs to the 'phage' integrase family
V060002_RS00160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
V060002_RS00165	COG0706	membrane insertase activity
V060002_RS00175	COG0594	ribonuclease P activity
V060002_RS00180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
V060002_RS00185	COG1126	abc transporter atp-binding protein
V060002_RS00200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
V060002_RS00205	COG0592	DNA-directed DNA polymerase activity
V060002_RS00210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
V060002_RS00215	COG0187	DNA topoisomerase II activity
V060002_RS00230	COG0071	Belongs to the small heat shock protein (HSP20) family
V060002_RS00235	COG3977	Valine--pyruvate aminotransferase
V060002_RS00245	COG0751	glycine-tRNA ligase activity
V060002_RS00250	COG0752	glycyl-tRNA synthetase alpha subunit
V060002_RS00255	COG2119	membrane
V060002_RS00270	COG0425	Belongs to the sulfur carrier protein TusA family
V060002_RS00280	COG0604	alcohol dehydrogenase
V060002_RS00290	COG0129	dihydroxy-acid dehydratase activity
V060002_RS00295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V060002_RS00310	COG0606	chelatase, subunit chli
V060002_RS00315	COG0204	Acyl-transferase
V060002_RS00320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V060002_RS00325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
V060002_RS00340	COG3084	Protein conserved in bacteria
V060002_RS00350	COG4326	sporulation control protein
V060002_RS00355	COG1272	protein, Hemolysin III
V060002_RS00365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V060002_RS00370	COG0569	domain protein
V060002_RS00375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V060002_RS00375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
V060002_RS00380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
V060002_RS00385	COG0242	peptide deformylase activity
V060002_RS00390	COG1652	LysM domain
V060002_RS00395	COG0758	DNA mediated transformation
V060002_RS00400	COG2922	Belongs to the Smg family
V060002_RS00405	COG0551	DNA topoisomerase type I activity
V060002_RS00410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
V060002_RS00415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
V060002_RS00420	COG0009	L-threonylcarbamoyladenylate synthase
V060002_RS00425	COG0408	coproporphyrinogen oxidase activity
V060002_RS00430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
V060002_RS00440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
V060002_RS00480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
V060002_RS00485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
V060002_RS00495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V060002_RS00500	COG2104	thiamine diphosphate biosynthetic process
V060002_RS00505	COG2022	thiamine diphosphate biosynthetic process
V060002_RS00510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V060002_RS00515	COG0006	proline dipeptidase activity
V060002_RS00515	COG0006	proline dipeptidase activity
V060002_RS00535	COG1522	sequence-specific DNA binding
V060002_RS00540	COG5002	protein histidine kinase activity
V060002_RS00540	COG5001	Diguanylate cyclase
V060002_RS00560	COG0589	response to stress
V060002_RS00570	COG1528	Iron-storage protein
V060002_RS00580	COG2081	HI0933 family
V060002_RS00590	COG1322	Protein conserved in bacteria
V060002_RS00595	COG2226	methyltransferase
V060002_RS00610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V060002_RS00615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V060002_RS00620	COG0805	protein transport
V060002_RS00625	COG1858	cytochrome C peroxidase
V060002_RS00630	COG0534	Mate efflux family protein
V060002_RS00640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
V060002_RS00655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
V060002_RS00660	COG3161	chorismate lyase activity
V060002_RS00670	COG1580	Controls the rotational direction of flagella during chemotaxis
V060002_RS00675	COG0840	transmembrane signaling receptor activity
V060002_RS00685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V060002_RS00695	COG0084	hydrolase, TatD family'
V060002_RS00710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V060002_RS00710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V060002_RS00730	COG3078	GTPase activator activity
V060002_RS00745	COG3071	HemY protein
V060002_RS00750	COG2959	enzyme of heme biosynthesis
V060002_RS00755	COG1587	Uroporphyrinogen-III synthase
V060002_RS00760	COG0181	hydroxymethylbilane synthase activity
V060002_RS00775	COG1965	Belongs to the frataxin family
V060002_RS00785	COG0019	diaminopimelate decarboxylase activity
V060002_RS00790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
V060002_RS00800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
V060002_RS00805	COG1011	Hydrolase
V060002_RS00810	COG2199	diguanylate cyclase activity
V060002_RS00810	COG2200	EAL domain
V060002_RS00810	COG3287	FIST C domain
V060002_RS00830	COG0561	phosphatase activity
V060002_RS00835	COG2267	carboxylic ester hydrolase activity
V060002_RS00840	COG1280	lysine exporter protein (LysE YggA)
V060002_RS00845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V060002_RS00850	COG0783	Belongs to the Dps family
V060002_RS00890	COG0742	ribosomal rna small subunit methyltransferase
V060002_RS00895	COG0552	protein localization to endoplasmic reticulum
V060002_RS00900	COG2884	Cell division ATP-binding protein ftsE
V060002_RS00905	COG2177	Part of the ABC transporter FtsEX involved in
V060002_RS00910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V060002_RS00915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_RS00935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V060002_RS00940	COG4206	TonB-dependent receptor
V060002_RS00945	COG1404	Belongs to the peptidase S8 family
V060002_RS00950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
V060002_RS01020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
V060002_RS01025	COG5001	Diguanylate cyclase
V060002_RS01025	COG3300	MHYT domain
V060002_RS01035	COG3852	Histidine kinase
V060002_RS01045	COG0174	glutamine synthetase
V060002_RS01055	COG1217	gtp-binding protein TYPA
V060002_RS01060	COG1660	Displays ATPase and GTPase activities
V060002_RS01065	COG1295	ribonuclease BN
V060002_RS01070	COG1490	D-aminoacyl-tRNA deacylase activity
V060002_RS01075	COG0456	acetyltransferase
V060002_RS01085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
V060002_RS01090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
V060002_RS01095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
V060002_RS01100	COG3031	protein transport across the cell outer membrane
V060002_RS01110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_RS01115	COG1459	type II secretion system
V060002_RS01120	COG2165	general secretion pathway protein
V060002_RS01125	COG2165	general secretion pathway protein
V060002_RS01130	COG2165	general secretion pathway protein
V060002_RS01135	COG4795	General secretion pathway protein
V060002_RS01140	COG3156	type II secretion system protein K
V060002_RS01145	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V060002_RS01150	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
V060002_RS01160	COG1218	3'(2'),5'-bisphosphate nucleotidase
V060002_RS01165	COG0494	nUDIX hydrolase
V060002_RS01175	COG1040	competence protein
V060002_RS01180	COG0596	Alpha beta hydrolase
V060002_RS01190	COG2183	response to ionizing radiation
V060002_RS01195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V060002_RS01210	COG2233	PERMEase
V060002_RS01215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
V060002_RS01220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V060002_RS01225	COG1758	RNA polymerase activity
V060002_RS01230	COG0194	GDP metabolic process
V060002_RS01235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
V060002_RS01240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V060002_RS01260	COG4232	protein-disulfide reductase activity
V060002_RS01275	COG1027	Aspartate ammonia-lyase
V060002_RS01280	COG3706	GGDEF domain
V060002_RS01285	COG3030	protein affecting phage T7 exclusion by the F plasmid
V060002_RS01290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
V060002_RS01300	COG2205	protein histidine kinase activity
V060002_RS01305	COG0745	RESPONSE REGULATOR receiver
V060002_RS01315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
V060002_RS01320	COG0205	6-phosphofructokinase activity
V060002_RS01325	COG1494	fructose-1,6-bisphosphatase
V060002_RS01335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
V060002_RS01340	COG0460	homoserine dehydrogenase
V060002_RS01340	COG0527	aspartate kinase activity
V060002_RS01345	COG0626	cystathionine gamma-synthase activity
V060002_RS01350	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
V060002_RS01355	COG0281	malic enzyme
V060002_RS01360	COG0254	rRNA binding
V060002_RS01365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
V060002_RS01370	COG1609	Transcriptional regulator
V060002_RS01375	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
V060002_RS01380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
V060002_RS01385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
V060002_RS01390	COG1575	Belongs to the MenA family. Type 1 subfamily
V060002_RS01395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V060002_RS01400	COG0534	Mate efflux family protein
V060002_RS01405	COG0149	triose-phosphate isomerase activity
V060002_RS01435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
V060002_RS01440	COG0459	protein refolding
V060002_RS01450	COG1509	lysine 2,3-aminomutase activity
V060002_RS01455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
V060002_RS01465	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
V060002_RS01470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
V060002_RS01475	COG1053	succinate dehydrogenase
V060002_RS01480	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
V060002_RS01485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V060002_RS01490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
V060002_RS01495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
V060002_RS01500	COG1045	serine acetyltransferase
V060002_RS01510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
V060002_RS01515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
V060002_RS01520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
V060002_RS01525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V060002_RS01530	COG0137	argininosuccinate synthase activity
V060002_RS01540	COG0165	Argininosuccinate lyase
V060002_RS01550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_RS01555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
V060002_RS01555	COG0678	peroxiredoxin activity
V060002_RS01565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
V060002_RS01595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
V060002_RS01600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
V060002_RS01610	COG0338	D12 class N6 adenine-specific DNA methyltransferase
V060002_RS01615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
V060002_RS01620	COG0546	phosphoglycolate phosphatase activity
V060002_RS01625	COG0180	Tryptophanyl-tRNA synthetase
V060002_RS01640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V060002_RS01650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
V060002_RS01660	COG1012	belongs to the aldehyde dehydrogenase family
V060002_RS01675	COG3954	Phosphoribulokinase
V060002_RS01685	COG0429	hydrolase of the alpha beta-hydrolase fold
V060002_RS01695	COG0488	(ABC) transporter
V060002_RS01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
V060002_RS01715	COG1047	Peptidyl-prolyl cis-trans
V060002_RS01735	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
V060002_RS01740	COG3083	sulfuric ester hydrolase activity
V060002_RS01745	COG0557	exoribonuclease II activity
V060002_RS01750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
V060002_RS01755	COG0051	transcription antitermination factor activity, RNA binding
V060002_RS01760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
V060002_RS01765	COG0088	Forms part of the polypeptide exit tunnel
V060002_RS01770	COG0089	rRNA binding
V060002_RS01775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
V060002_RS01780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
V060002_RS01785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
V060002_RS01790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
V060002_RS01795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
V060002_RS01800	COG0255	Belongs to the universal ribosomal protein uL29 family
V060002_RS01805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
V060002_RS01810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
V060002_RS01815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
V060002_RS01820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
V060002_RS01825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
V060002_RS01830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
V060002_RS01840	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
V060002_RS01845	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
V060002_RS01850	COG1841	ribosomal large subunit assembly
V060002_RS01860	COG0201	protein transport
V060002_RS01865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
V060002_RS01870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
V060002_RS01875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
V060002_RS01880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
V060002_RS01885	COG0202	RNA polymerase activity
V060002_RS01890	COG0203	ribosomal protein L17
V060002_RS01900	COG0545	Peptidyl-prolyl cis-trans isomerase
V060002_RS01905	COG3266	domain, Protein
V060002_RS01905	COG3061	Opacity-associated protein A
V060002_RS01910	COG0697	spore germination
V060002_RS01915	COG2153	protein acetylation
V060002_RS01920	COG0513	Belongs to the DEAD box helicase family
V060002_RS01930	COG0737	Belongs to the 5'-nucleotidase family
V060002_RS01935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
V060002_RS01935	COG1648	precorrin-2 dehydrogenase activity
V060002_RS01950	COG0529	Catalyzes the synthesis of activated sulfate
V060002_RS01970	COG1136	(ABC) transporter
V060002_RS01985	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
V060002_RS01990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_RS01995	COG0729	surface antigen
V060002_RS02005	COG2105	PFAM AIG2 family protein
V060002_RS02010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
V060002_RS02025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V060002_RS02030	COG0163	prenyltransferase activity
V060002_RS02040	COG1178	ABC-type Fe3 transport system permease component
V060002_RS02045	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
V060002_RS02050	COG3028	Belongs to the UPF0307 family
V060002_RS02055	COG0312	modulator of DNA gyrase
V060002_RS02060	COG2239	Acts as a magnesium transporter
V060002_RS02065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_RS02070	COG1660	Displays ATPase and GTPase activities
V060002_RS02075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_RS02080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
V060002_RS02090	COG1137	ATPase activity
V060002_RS02095	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
V060002_RS02110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
V060002_RS02110	COG0517	IMP dehydrogenase activity
V060002_RS02125	COG1127	ABC transporter
V060002_RS02130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
V060002_RS02135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V060002_RS02140	COG2854	intermembrane phospholipid transfer
V060002_RS02150	COG5007	Belongs to the BolA IbaG family
V060002_RS02155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
V060002_RS02165	COG0251	oxidation-reduction process
V060002_RS02175	COG0540	Belongs to the ATCase OTCase family
V060002_RS02185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
V060002_RS02200	COG0564	pseudouridine synthase activity
V060002_RS02205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V060002_RS02210	COG0525	valine-tRNA ligase activity
V060002_RS02215	COG2927	DNA polymerase III (CHI subunit)
V060002_RS02220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V060002_RS02225	COG0795	lipopolysaccharide-transporting ATPase activity
V060002_RS02230	COG0795	lipopolysaccharide-transporting ATPase activity
V060002_RS02245	COG3437	response regulator, receiver
V060002_RS02290	COG0066	3-isopropylmalate dehydratase activity
V060002_RS02295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
V060002_RS02300	COG0473	3-isopropylmalate dehydrogenase activity
V060002_RS02325	COG0583	DNA-binding transcription factor activity
V060002_RS02330	COG1022	Amp-dependent synthetase and ligase
V060002_RS02335	COG0028	Belongs to the TPP enzyme family
V060002_RS02340	COG0440	acetolactate synthase activity
V060002_RS02345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V060002_RS02350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
V060002_RS02355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
V060002_RS02365	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
V060002_RS02370	COG3079	Belongs to the UPF0149 family
V060002_RS02375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_RS02380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_RS02395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
V060002_RS02405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
V060002_RS02415	COG1595	DNA-templated transcription, initiation
V060002_RS02430	COG3086	response to oxidative stress
V060002_RS02435	COG0481	GTPase activity
V060002_RS02450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
V060002_RS02455	COG1381	Involved in DNA repair and RecF pathway recombination
V060002_RS02460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
V060002_RS02480	COG5001	Diguanylate cyclase
V060002_RS02495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
V060002_RS02500	COG3956	TIGRFAM MazG family protein
V060002_RS02505	COG0504	CTP synthase activity
V060002_RS02510	COG0148	phosphopyruvate hydratase activity
V060002_RS02520	COG3409	Peptidoglycan-binding domain 1 protein
V060002_RS02520	COG3267	Type II secretory pathway component ExeA
V060002_RS02530	COG4991	sh3 domain protein
V060002_RS02535	COG0306	phosphate transporter
V060002_RS02540	COG1392	Phosphate transport regulator
V060002_RS02545	COG3025	triphosphatase activity
V060002_RS02550	COG0840	transmembrane signaling receptor activity
V060002_RS02565	COG0148	phosphopyruvate hydratase activity
V060002_RS02575	COG3267	Type II secretory pathway component ExeA
V060002_RS02575	COG3409	Peptidoglycan-binding domain 1 protein
V060002_RS02585	COG4991	sh3 domain protein
V060002_RS02590	COG0306	phosphate transporter
V060002_RS02595	COG1392	Phosphate transport regulator
V060002_RS02600	COG3025	triphosphatase activity
V060002_RS02605	COG0840	transmembrane signaling receptor activity
V060002_RS02610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
V060002_RS02620	COG1538	Outer membrane efflux protein
V060002_RS02625	COG0494	nUDIX hydrolase
V060002_RS02630	COG3151	Protein conserved in bacteria
V060002_RS02640	COG3150	esterase
V060002_RS02645	COG0187	DNA topoisomerase II activity
V060002_RS02650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
V060002_RS02660	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
V060002_RS02665	COG0237	dephospho-CoA kinase activity
V060002_RS02675	COG1459	type II secretion system
V060002_RS02680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_RS02700	COG0716	FMN binding
V060002_RS02705	COG4974	Belongs to the 'phage' integrase family
V060002_RS02710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
V060002_RS02715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
V060002_RS02720	COG0737	Belongs to the 5'-nucleotidase family
V060002_RS02730	COG2186	Transcriptional regulator
V060002_RS02735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
V060002_RS02740	COG0508	dehydrogenase complex catalyzes the overall conversion of
V060002_RS02745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_RS02760	COG3116	cell division
V060002_RS02765	COG0768	penicillin binding
V060002_RS02770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
V060002_RS02775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
V060002_RS02785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
V060002_RS02790	COG0772	Belongs to the SEDS family
V060002_RS02800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
V060002_RS02805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
V060002_RS02810	COG0849	cell division
V060002_RS02815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
V060002_RS02820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
V060002_RS02830	COG0653	protein targeting
V060002_RS02835	COG0494	nUDIX hydrolase
V060002_RS02840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
V060002_RS02850	COG0505	Belongs to the CarA family
V060002_RS02855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
V060002_RS02875	COG4172	Belongs to the ABC transporter superfamily
V060002_RS02885	COG0730	response to heat
V060002_RS02890	COG0583	DNA-binding transcription factor activity
V060002_RS02895	COG2860	membrane
V060002_RS02900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
V060002_RS02910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
V060002_RS02920	COG0493	'glutamate synthase
V060002_RS02925	COG0067	glutamate synthase
V060002_RS02925	COG0070	glutamate synthase
V060002_RS02925	COG0069	glutamate synthase activity
V060002_RS02935	COG0069	glutamate synthase activity
V060002_RS02935	COG0070	glutamate synthase
V060002_RS02935	COG0067	glutamate synthase
V060002_RS02940	COG1242	4 iron, 4 sulfur cluster binding
V060002_RS02945	COG3706	GGDEF domain
V060002_RS02945	COG4251	negative regulation of phosphorylation
V060002_RS02945	COG5001	Diguanylate cyclase
V060002_RS02945	COG2203	Gaf domain
V060002_RS02950	COG5002	protein histidine kinase activity
V060002_RS02950	COG2198	Histidine kinase
V060002_RS02950	COG0784	Response regulator, receiver
V060002_RS02955	COG0745	RESPONSE REGULATOR receiver
V060002_RS02965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
V060002_RS02990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
V060002_RS02995	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
V060002_RS03000	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
V060002_RS03005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
V060002_RS03020	COG1115	amino acid carrier protein
V060002_RS03025	COG3022	response to hydroperoxide
V060002_RS03030	COG0084	hydrolase, TatD family'
V060002_RS03035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V060002_RS03045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
V060002_RS03050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
V060002_RS03055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
V060002_RS03060	COG0813	purine-nucleoside phosphorylase activity
V060002_RS03070	COG0560	Phosphoserine phosphatase
V060002_RS03085	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
V060002_RS03090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
V060002_RS03095	COG1022	Amp-dependent synthetase and ligase
V060002_RS03110	COG3250	beta-galactosidase activity
V060002_RS03115	COG1609	Transcriptional regulator
V060002_RS03120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_RS03135	COG0189	ligase activity
V060002_RS03135	COG0569	domain protein
V060002_RS03140	COG0456	acetyltransferase
V060002_RS03150	COG2171	N-acyltransferase activity
V060002_RS03155	COG3141	response to X-ray
V060002_RS03170	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
V060002_RS03175	COG1074	ATP-dependent DNA helicase activity
V060002_RS03180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
V060002_RS03190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
V060002_RS03190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
V060002_RS03200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
V060002_RS03205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
V060002_RS03210	COG2166	iron-sulfur cluster assembly
V060002_RS03215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V060002_RS03220	COG0693	protein deglycase activity
V060002_RS03225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
V060002_RS03230	COG3248	Nucleoside-binding outer membrane protein
V060002_RS03240	COG1595	DNA-templated transcription, initiation
V060002_RS03250	COG2211	Major facilitator Superfamily
V060002_RS03260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V060002_RS03270	COG2813	Specifically methylates the guanine in position
V060002_RS03275	COG0271	Belongs to the BolA IbaG family
V060002_RS03280	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_RS03285	COG1805	sodium ion transport
V060002_RS03290	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_RS03295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_RS03300	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
V060002_RS03305	COG2871	sodium ion transport
V060002_RS03310	COG1477	protein flavinylation
V060002_RS03335	COG0733	neurotransmitter:sodium symporter activity
V060002_RS03345	COG0189	ligase activity
V060002_RS03350	COG0189	ligase activity
V060002_RS03350	COG4067	protein conserved in archaea
V060002_RS03355	COG2195	Cleaves the N-terminal amino acid of tripeptides
V060002_RS03360	COG2252	PERMEase
V060002_RS03365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
V060002_RS03370	COG1073	alpha beta
V060002_RS03380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
V060002_RS03385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
V060002_RS03390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
V060002_RS03395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V060002_RS03395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
V060002_RS03410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
V060002_RS03415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
V060002_RS03420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
V060002_RS03425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
V060002_RS03440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
V060002_RS03445	COG0024	Methionine aminopeptidase
V060002_RS03450	COG0052	Belongs to the universal ribosomal protein uS2 family
V060002_RS03455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
V060002_RS03460	COG0528	UMP kinase activity
V060002_RS03465	COG0233	cytoplasmic translational termination
V060002_RS03470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
V060002_RS03475	COG0575	Belongs to the CDS family
V060002_RS03480	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
V060002_RS03485	COG0750	zinc metalloprotease
V060002_RS03495	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
V060002_RS03500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_RS03505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V060002_RS03510	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_RS03515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_RS03520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
V060002_RS03525	COG0587	DNA-directed DNA polymerase activity
V060002_RS03530	COG0825	malonyl-CoA metabolic process
V060002_RS03535	COG0037	tRNA processing
V060002_RS03545	COG3479	Phenolic acid decarboxylase
V060002_RS03550	COG0347	Belongs to the P(II) protein family
V060002_RS03555	COG3021	interspecies interaction between organisms
V060002_RS03560	COG0741	lytic transglycosylase activity
V060002_RS03560	COG1388	LysM domain
V060002_RS03565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V060002_RS03570	COG2226	methyltransferase
V060002_RS03575	COG0328	RNA-DNA hybrid ribonuclease activity
V060002_RS03590	COG1960	acyl-CoA dehydrogenase activity
V060002_RS03595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V060002_RS03600	COG0121	glutamine amidotransferase
V060002_RS03605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
V060002_RS03610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
V060002_RS03615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
V060002_RS03625	COG1187	pseudouridine synthase activity
V060002_RS03630	COG2840	Smr protein MutS2
V060002_RS03645	COG3735	TraB family
V060002_RS03660	COG2608	mercury ion transmembrane transporter activity
V060002_RS03660	COG2217	Heavy metal translocating P-type atpase
V060002_RS03665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V060002_RS03680	COG1629	transport
V060002_RS03680	COG4774	siderophore transport
V060002_RS03685	COG2375	cellular response to nickel ion
V060002_RS03690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V060002_RS03690	COG3433	isochorismatase activity
V060002_RS03690	COG2226	methyltransferase
V060002_RS03725	COG0784	Response regulator, receiver
V060002_RS03725	COG0835	chemotaxis
V060002_RS03730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V060002_RS03735	COG1815	bacterial-type flagellum-dependent cell motility
V060002_RS03750	COG1749	Flagellar hook protein flgE
V060002_RS03755	COG4787	bacterial-type flagellum-dependent cell motility
V060002_RS03765	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
V060002_RS03770	COG1706	bacterial-type flagellum-dependent cell motility
V060002_RS03775	COG3951	Flagellar rod assembly protein muramidase FlgJ
V060002_RS03775	COG1705	Flagellar rod assembly protein muramidase FlgJ
V060002_RS03790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_RS03795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_RS03880	COG0012	GTP binding
V060002_RS03885	COG0193	aminoacyl-tRNA hydrolase activity
V060002_RS03890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
V060002_RS03900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
V060002_RS03905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
V060002_RS03910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
V060002_RS03915	COG2890	protein-(glutamine-N5) methyltransferase activity
V060002_RS03925	COG2912	Transglutaminase-like superfamily
V060002_RS03930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
V060002_RS03935	COG0737	Belongs to the 5'-nucleotidase family
V060002_RS03940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
V060002_RS03945	COG2233	PERMEase
V060002_RS03965	COG1393	Belongs to the ArsC family
V060002_RS03970	COG4783	chaperone-mediated protein folding
V060002_RS03985	COG0840	transmembrane signaling receptor activity
V060002_RS03990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
V060002_RS04005	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
V060002_RS04015	COG1876	peptidase activity
V060002_RS04025	COG1393	Belongs to the ArsC family
V060002_RS04045	COG2837	iron assimilation
V060002_RS04050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_RS04055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_RS04060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
V060002_RS04065	COG1334	flagellar protein FlaG
V060002_RS04070	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
V060002_RS04080	COG1516	flagellar protein fliS
V060002_RS04100	COG1677	Flagellar hook-basal body complex protein FliE
V060002_RS04110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
V060002_RS04115	COG1317	bacterial-type flagellum organization
V060002_RS04140	COG1580	Controls the rotational direction of flagella during chemotaxis
V060002_RS04165	COG1987	bacterial-type flagellum assembly
V060002_RS04170	COG1684	flagellar biosynthetic protein fliR
V060002_RS04180	COG2840	Smr protein MutS2
V060002_RS04185	COG2890	protein-(glutamine-N5) methyltransferase activity
V060002_RS04195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
V060002_RS04200	COG2860	membrane
V060002_RS04205	COG3101	peptidyl-lysine hydroxylation
V060002_RS04215	COG0431	NADPH-dependent FMN reductase
V060002_RS04225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V060002_RS04230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V060002_RS04235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V060002_RS04240	COG0735	belongs to the Fur family
V060002_RS04250	COG0583	DNA-binding transcription factor activity
V060002_RS04260	COG1346	cytolysis
V060002_RS04275	COG0596	Alpha beta hydrolase
V060002_RS04280	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
V060002_RS04285	COG0033	Phosphoglucomutase
V060002_RS04295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
V060002_RS04300	COG0372	Belongs to the citrate synthase family
V060002_RS04305	COG2009	succinate dehydrogenase
V060002_RS04310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
V060002_RS04315	COG1053	succinate dehydrogenase
V060002_RS04325	COG0567	Dehydrogenase, E1 component
V060002_RS04330	COG0508	dehydrogenase complex catalyzes the overall conversion of
V060002_RS04335	COG0045	succinate-CoA ligase (ADP-forming) activity
V060002_RS04345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
V060002_RS04350	COG1121	(ABC) transporter
V060002_RS04355	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
V060002_RS04360	COG4977	sequence-specific DNA binding
V060002_RS04365	COG1918	ferrous iron import across plasma membrane
V060002_RS04385	COG0018	arginyl-trna synthetase
V060002_RS04395	COG1025	Belongs to the peptidase M16 family
V060002_RS04400	COG2062	phosphohistidine phosphatase, SixA
V060002_RS04430	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
V060002_RS04435	COG0643	Histidine kinase
V060002_RS04435	COG0784	Response regulator, receiver
V060002_RS04435	COG2198	Histidine kinase
V060002_RS04440	COG2201	protein-glutamate methylesterase activity
V060002_RS04445	COG1192	Involved in chromosome partitioning
V060002_RS04455	COG0835	chemotaxis
V060002_RS04465	COG4133	protoheme IX ABC transporter activity
V060002_RS04470	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V060002_RS04475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
V060002_RS04485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
V060002_RS04490	COG1138	Cytochrome C-type biogenesis protein
V060002_RS04495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
V060002_RS04500	COG3088	subunit of a heme lyase
V060002_RS04500	COG4235	cytochrome complex assembly
V060002_RS04510	COG2853	Lipoprotein
V060002_RS04530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
V060002_RS04535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V060002_RS04540	COG0123	including yeast histone deacetylase and acetoin utilization protein
V060002_RS04555	COG3083	sulfuric ester hydrolase activity
V060002_RS04560	COG3082	Protein of unknown function (DUF1414)
V060002_RS04565	COG3081	Nucleoid-associated protein
V060002_RS04575	COG1757	Na H antiporter
V060002_RS04580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
V060002_RS04585	COG2095	MarC family integral membrane protein
V060002_RS04590	COG1012	belongs to the aldehyde dehydrogenase family
V060002_RS04590	COG1454	alcohol dehydrogenase
V060002_RS04605	COG0659	secondary active sulfate transmembrane transporter activity
V060002_RS04610	COG1530	ribonuclease E activity
V060002_RS04625	COG0564	pseudouridine synthase activity
V060002_RS04630	COG0424	maF-like protein
V060002_RS04635	COG1399	metal-binding, possibly nucleic acid-binding protein
V060002_RS04640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
V060002_RS04645	COG0416	fatty acid biosynthetic process
V060002_RS04650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
V060002_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_RS04665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
V060002_RS04670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
V060002_RS04675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
V060002_RS04680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
V060002_RS04685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
V060002_RS04695	COG0084	hydrolase, TatD family'
V060002_RS04700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_RS04700	COG1263	PTS System
V060002_RS04710	COG0733	neurotransmitter:sodium symporter activity
V060002_RS04725	COG4667	esterase of the alpha-beta hydrolase superfamily
V060002_RS04735	COG1940	carbohydrate kinase activity
V060002_RS04740	COG0784	Response regulator, receiver
V060002_RS04740	COG0835	chemotaxis
V060002_RS04755	COG2226	methyltransferase
V060002_RS04775	COG0676	glucose-6-phosphate 1-epimerase activity
V060002_RS04780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V060002_RS04785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_RS04795	COG3139	Protein of unknown function (DUF1315)
V060002_RS04800	COG0252	asparaginase activity
V060002_RS04805	COG0616	signal peptide processing
V060002_RS04810	COG0446	pyridine nucleotide-disulphide oxidoreductase
V060002_RS04810	COG1902	pentaerythritol trinitrate reductase activity
V060002_RS04815	COG0788	formyltetrahydrofolate deformylase activity
V060002_RS04830	COG1199	ATP-dependent helicase activity
V060002_RS04835	COG1214	PFAM Peptidase M22, glycoprotease
V060002_RS04850	COG0596	Alpha beta hydrolase
V060002_RS04860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
V060002_RS04880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
V060002_RS04885	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
V060002_RS04890	COG0436	Aminotransferase
V060002_RS04895	COG1169	isochorismate synthase
V060002_RS04900	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
V060002_RS04905	COG0596	Alpha beta hydrolase
V060002_RS04925	COG3135	benzoate transporter
V060002_RS04930	COG1396	sequence-specific DNA binding
V060002_RS04935	COG0840	transmembrane signaling receptor activity
V060002_RS04940	COG0477	Major facilitator Superfamily
V060002_RS04960	COG3015	lipoprotein NlpE involved in copper resistance
V060002_RS04965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
V060002_RS04970	COG2894	cell division
V060002_RS04975	COG0850	regulation of cytokinetic process
V060002_RS04980	COG3100	YcgL domain-containing protein
V060002_RS04985	COG2951	lytic endotransglycosylase activity
V060002_RS04995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V060002_RS05000	COG3469	chitinase activity
V060002_RS05000	COG3325	Belongs to the glycosyl hydrolase 18 family
V060002_RS05005	COG3005	denitrification pathway
V060002_RS05010	COG0243	molybdopterin cofactor binding
V060002_RS05030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_RS05040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
V060002_RS05080	COG4589	Belongs to the CDS family
V060002_RS05090	COG3300	MHYT domain
V060002_RS05090	COG5001	Diguanylate cyclase
V060002_RS05105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
V060002_RS05110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
V060002_RS05115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
V060002_RS05120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
V060002_RS05130	COG4191	Histidine kinase
V060002_RS05140	COG0544	peptidyl-prolyl cis-trans isomerase activity
V060002_RS05150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
V060002_RS05155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
V060002_RS05160	COG0776	regulation of translation
V060002_RS05165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V060002_RS05170	COG1555	photosystem II stabilization
V060002_RS05175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
V060002_RS05185	COG0776	regulation of translation
V060002_RS05190	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
V060002_RS05195	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
V060002_RS05215	COG0583	DNA-binding transcription factor activity
V060002_RS05225	COG0686	Belongs to the AlaDH PNT family
V060002_RS05235	COG1674	ftsk spoiiie
V060002_RS05240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
V060002_RS05245	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V060002_RS05250	COG2186	Transcriptional regulator
V060002_RS05265	COG0537	adenosine 5'-monophosphoramidase activity
V060002_RS05290	COG3150	esterase
V060002_RS05295	COG1252	NADH dehydrogenase
V060002_RS05315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
V060002_RS05325	COG4591	ABC-type transport system involved in lipoprotein release permease component
V060002_RS05330	COG1136	(ABC) transporter
V060002_RS05335	COG4591	ABC-type transport system involved in lipoprotein release permease component
V060002_RS05345	COG2333	competence protein COMEC
V060002_RS05345	COG0658	competence protein
V060002_RS05350	COG1132	(ABC) transporter
V060002_RS05355	COG1663	tetraacyldisaccharide 4'-kinase activity
V060002_RS05360	COG2835	tetraacyldisaccharide 4'-kinase activity
V060002_RS05365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
V060002_RS05370	COG2719	SpoVR family
V060002_RS05375	COG2718	Belongs to the UPF0229 family
V060002_RS05380	COG2766	serine protein kinase
V060002_RS05385	COG3013	Belongs to the UPF0304 family
V060002_RS05395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
V060002_RS05400	COG0840	transmembrane signaling receptor activity
V060002_RS05410	COG1882	Formate acetyltransferase
V060002_RS05440	COG4160	amino acid transport
V060002_RS05445	COG0708	Exodeoxyribonuclease III
V060002_RS05450	COG0840	transmembrane signaling receptor activity
V060002_RS05460	COG3923	Primosomal replication protein n
V060002_RS05465	COG0730	response to heat
V060002_RS05470	COG1199	ATP-dependent helicase activity
V060002_RS05475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V060002_RS05480	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V060002_RS05485	COG3012	SEC-C Motif Domain Protein
V060002_RS05490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V060002_RS05495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
V060002_RS05500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
V060002_RS05505	COG0215	cysteine-tRNA ligase activity
V060002_RS05510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
V060002_RS05515	COG0632	four-way junction helicase activity
V060002_RS05525	COG1271	oxidase subunit
V060002_RS05530	COG1294	oxidase, subunit
V060002_RS05535	COG4890	Cyd operon protein YbgT
V060002_RS05540	COG3790	cyd operon protein YbgE
V060002_RS05545	COG0824	Thioesterase
V060002_RS05550	COG0811	peptide transport
V060002_RS05565	COG0823	Involved in the tonB-independent uptake of proteins
V060002_RS05570	COG2885	chlorophyll binding
V060002_RS05580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
V060002_RS05590	COG0784	Response regulator, receiver
V060002_RS05590	COG5002	protein histidine kinase activity
V060002_RS05600	COG1482	cell wall glycoprotein biosynthetic process
V060002_RS05605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_RS05605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_RS05605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_RS05610	COG2207	Transcriptional regulator
V060002_RS05620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_RS05625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_RS05630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_RS05640	COG1012	belongs to the aldehyde dehydrogenase family
V060002_RS05645	COG3284	Transcriptional regulator
V060002_RS05650	COG4628	conserved protein (DUF2132)
V060002_RS05660	COG0415	Belongs to the DNA photolyase family
V060002_RS05740	COG0488	(ABC) transporter
V060002_RS05785	COG3941	tape measure
V060002_RS05805	COG0484	heat shock protein binding
V060002_RS05820	COG5001	Diguanylate cyclase
V060002_RS05820	COG1716	ATPase activity
V060002_RS05825	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V060002_RS05835	COG4181	ATPase activity
V060002_RS05840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
V060002_RS05855	COG1984	allophanate hydrolase subunit 2
V060002_RS05865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
V060002_RS05875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
V060002_RS05880	COG0840	transmembrane signaling receptor activity
V060002_RS05885	COG0814	amino acid
V060002_RS05895	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
V060002_RS05900	COG0513	Belongs to the DEAD box helicase family
V060002_RS05905	COG1309	transcriptional regulator
V060002_RS05915	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
V060002_RS05920	COG0494	nUDIX hydrolase
V060002_RS05930	COG2425	protein containing a von Willebrand factor type A (vWA) domain
V060002_RS05940	COG1126	abc transporter atp-binding protein
V060002_RS05945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_RS05950	COG4215	(ABC) transporter
V060002_RS05955	COG4160	amino acid transport
V060002_RS05960	COG0583	DNA-binding transcription factor activity
V060002_RS05990	COG3118	belongs to the thioredoxin family
V060002_RS05995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
V060002_RS06000	COG0247	lactate metabolic process
V060002_RS06005	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
V060002_RS06010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
V060002_RS06015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
V060002_RS06020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
V060002_RS06035	COG2926	Belongs to the UPF0265 family
V060002_RS06050	COG2827	Endonuclease containing a URI domain
V060002_RS06060	COG1879	ABC-type sugar transport system periplasmic component
V060002_RS06065	COG0784	Response regulator, receiver
V060002_RS06065	COG5002	protein histidine kinase activity
V060002_RS06110	COG1492	cobalamin metabolic process
V060002_RS06115	COG0725	ABC transporter, periplasmic molybdate-binding protein
V060002_RS06120	COG4149	molybdate abc transporter
V060002_RS06125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
V060002_RS06155	COG1289	transmembrane transporter activity
V060002_RS06160	COG0210	DNA helicase
V060002_RS06175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
V060002_RS06180	COG1335	isochorismatase
V060002_RS06185	COG1803	Methylglyoxal synthase
V060002_RS06190	COG1879	ABC-type sugar transport system periplasmic component
V060002_RS06195	COG2198	Histidine kinase
V060002_RS06195	COG2205	protein histidine kinase activity
V060002_RS06195	COG0784	Response regulator, receiver
V060002_RS06200	COG0469	pyruvate kinase activity
V060002_RS06205	COG2271	Major facilitator Superfamily
V060002_RS06215	COG4191	Histidine kinase
V060002_RS06230	COG1979	alcohol dehydrogenase
V060002_RS06240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V060002_RS06260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_RS06265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_RS06275	COG0183	Belongs to the thiolase family
V060002_RS06285	COG3243	poly(R)-hydroxyalkanoic acid synthase
V060002_RS06290	COG3842	ATPase activity
V060002_RS06300	COG1840	ABC-type Fe3 transport system, periplasmic component
V060002_RS06305	COG2271	Major facilitator Superfamily
V060002_RS06310	COG3851	Histidine kinase
V060002_RS06315	COG2197	response regulator
V060002_RS06320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V060002_RS06340	COG0243	molybdopterin cofactor binding
V060002_RS06350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V060002_RS06355	COG3850	Histidine kinase
V060002_RS06360	COG2197	response regulator
V060002_RS06365	COG1609	Transcriptional regulator
V060002_RS06385	COG1760	l-serine dehydratase
V060002_RS06390	COG3069	C4-dicarboxylate transmembrane transporter activity
V060002_RS06400	COG0840	transmembrane signaling receptor activity
V060002_RS06405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V060002_RS06410	COG0545	Peptidyl-prolyl cis-trans isomerase
V060002_RS06415	COG2885	chlorophyll binding
V060002_RS06425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
V060002_RS06430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_RS06435	COG1621	beta-fructofuranosidase activity
V060002_RS06440	COG1609	Transcriptional regulator
V060002_RS06445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_RS06445	COG1263	PTS System
V060002_RS06490	COG0446	pyridine nucleotide-disulphide oxidoreductase
V060002_RS06535	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
V060002_RS06540	COG0583	DNA-binding transcription factor activity
V060002_RS06565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
V060002_RS06590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
V060002_RS06605	COG2390	Transcriptional regulator
V060002_RS06610	COG2897	thiosulfate sulfurtransferase activity
V060002_RS06620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
V060002_RS06630	COG0302	gtp cyclohydrolase
V060002_RS06635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_RS06635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_RS06640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
V060002_RS06645	COG1970	mechanosensitive ion channel activity
V060002_RS06650	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
V060002_RS06660	COG1011	Hydrolase
V060002_RS06665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V060002_RS06670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V060002_RS06675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
V060002_RS06680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
V060002_RS06690	COG3842	ATPase activity
V060002_RS06710	COG3104	oligopeptide transport
V060002_RS06735	COG4166	transmembrane transport
V060002_RS06740	COG4174	ABC transporter (Permease)
V060002_RS06745	COG4239	(ABC) transporter, permease
V060002_RS06750	COG4172	Belongs to the ABC transporter superfamily
V060002_RS06755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
V060002_RS06770	COG0625	glutathione transferase activity
V060002_RS06795	COG2050	protein possibly involved in aromatic compounds catabolism
V060002_RS06810	COG1629	transport
V060002_RS06810	COG4771	TonB-dependent receptor
V060002_RS06815	COG0583	DNA-binding transcription factor activity
V060002_RS06820	COG1042	CoA-binding domain protein
V060002_RS06820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_RS06820	COG0045	succinate-CoA ligase (ADP-forming) activity
V060002_RS06840	COG0023	Translation Initiation Factor
V060002_RS06855	COG4128	Pfam Zonular occludens toxin
V060002_RS06910	COG4128	Pfam Zonular occludens toxin
V060002_RS06955	COG3140	Belongs to the UPF0181 family
V060002_RS06970	COG0745	RESPONSE REGULATOR receiver
V060002_RS06980	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
V060002_RS06985	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
V060002_RS07000	COG3706	GGDEF domain
V060002_RS07020	COG2199	diguanylate cyclase activity
V060002_RS07055	COG2824	Alkylphosphonate utilization operon protein PhnA
V060002_RS07070	COG0737	Belongs to the 5'-nucleotidase family
V060002_RS07075	COG3593	DNA synthesis involved in DNA repair
V060002_RS07085	COG0583	DNA-binding transcription factor activity
V060002_RS07090	COG2116	formate transmembrane transporter activity
V060002_RS07100	COG3038	cytochrome b561
V060002_RS07110	COG2200	EAL domain
V060002_RS07120	COG0586	Pfam SNARE associated Golgi protein
V060002_RS07125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
V060002_RS07130	COG0745	RESPONSE REGULATOR receiver
V060002_RS07135	COG2205	protein histidine kinase activity
V060002_RS07140	COG0674	pyruvate-flavodoxin oxidoreductase activity
V060002_RS07140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
V060002_RS07140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
V060002_RS07140	COG1013	pyruvate-flavodoxin oxidoreductase activity
V060002_RS07155	COG0523	cobalamin synthesis protein
V060002_RS07170	COG0156	8-amino-7-oxononanoate synthase activity
V060002_RS07180	COG2205	protein histidine kinase activity
V060002_RS07180	COG0784	Response regulator, receiver
V060002_RS07185	COG0419	ATPase involved in DNA repair
V060002_RS07190	COG0420	3'-5' exonuclease activity
V060002_RS07195	COG1609	Transcriptional regulator
V060002_RS07200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_RS07200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_RS07205	COG1105	Belongs to the carbohydrate kinase PfkB family
V060002_RS07210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
V060002_RS07210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_RS07210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
V060002_RS07215	COG4067	protein conserved in archaea
V060002_RS07215	COG0189	ligase activity
V060002_RS07225	COG0602	queuosine metabolic process
V060002_RS07230	COG1328	CTP reductase activity
V060002_RS07255	COG0346	lactoylglutathione lyase activity
V060002_RS07420	COG0346	lactoylglutathione lyase activity
V060002_RS07440	COG0110	maltose O-acetyltransferase activity
V060002_RS07445	COG3039	Transposase
V060002_RS07455	COG2944	sequence-specific DNA binding
V060002_RS07460	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
V060002_RS07565	COG4977	sequence-specific DNA binding
V060002_RS07635	COG3040	lipid binding
V060002_RS07660	COG1619	proteins homologs of microcin C7 resistance protein MccF
V060002_RS07685	COG3093	addiction module antidote protein HigA
V060002_RS07690	COG3549	Plasmid maintenance system killer
V060002_RS07945	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
V060002_RS07955	COG1619	proteins homologs of microcin C7 resistance protein MccF
V060002_RS08070	COG3041	Addiction module toxin RelE StbE family
V060002_RS08105	COG3040	lipid binding
V060002_RS08110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_RS08135	COG0494	nUDIX hydrolase
V060002_RS08165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
V060002_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_RS08270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
V060002_RS08275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
V060002_RS08310	COG3039	Transposase
V060002_RS08320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
V060002_RS08330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
V060002_RS08335	COG0509	glycine decarboxylation via glycine cleavage system
V060002_RS08340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V060002_RS08340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
V060002_RS08370	COG1686	Belongs to the peptidase S11 family
V060002_RS08385	COG2814	Major facilitator Superfamily
V060002_RS08400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
V060002_RS08425	COG5002	protein histidine kinase activity
V060002_RS08430	COG0745	RESPONSE REGULATOR receiver
V060002_RS08455	COG0366	Alpha amylase catalytic
V060002_RS08460	COG3038	cytochrome b561
V060002_RS08490	COG0561	phosphatase activity
V060002_RS08495	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
V060002_RS08500	COG3623	hexulose-6-phosphate isomerase
V060002_RS08510	COG0745	RESPONSE REGULATOR receiver
V060002_RS08530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
V060002_RS08545	COG2207	Transcriptional regulator
V060002_RS08550	COG4604	ABC transporter, ATP-binding protein
V060002_RS08555	COG4605	iron ion homeostasis
V060002_RS08560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_RS08585	COG5380	lipid catabolic process
V060002_RS08590	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
V060002_RS08595	COG0840	transmembrane signaling receptor activity
V060002_RS08605	COG3240	lipase activity
V060002_RS08610	COG3706	GGDEF domain
V060002_RS08620	COG2814	Major facilitator Superfamily
V060002_RS08625	COG1757	Na H antiporter
V060002_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_RS08635	COG4191	Histidine kinase
V060002_RS08640	COG3437	response regulator, receiver
V060002_RS08640	COG0784	Response regulator, receiver
V060002_RS08650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
V060002_RS08655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
V060002_RS08660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
V060002_RS08665	COG0513	Belongs to the DEAD box helicase family
V060002_RS08705	COG0516	GMP reductase activity
V060002_RS08720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V060002_RS08730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
V060002_RS08735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
V060002_RS08735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
V060002_RS08760	COG3036	rescue of stalled ribosome
V060002_RS08765	COG1278	Cold shock
V060002_RS08770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
V060002_RS08770	COG1017	nitric oxide dioxygenase activity
V060002_RS08775	COG3604	Transcriptional regulator
V060002_RS08785	COG2195	Cleaves the N-terminal amino acid of tripeptides
V060002_RS08790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
V060002_RS08805	COG0840	transmembrane signaling receptor activity
V060002_RS08810	COG0714	Associated with various cellular activities
V060002_RS08830	COG2304	oxidoreductase activity
V060002_RS08845	COG1278	Cold shock
V060002_RS08850	COG5002	protein histidine kinase activity
V060002_RS08850	COG5001	Diguanylate cyclase
V060002_RS08860	COG3530	Putative quorum-sensing-regulated virulence factor
V060002_RS08875	COG0814	amino acid
V060002_RS08880	COG0589	response to stress
V060002_RS08890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
V060002_RS08890	COG2111	Na H antiporter
V060002_RS08895	COG1006	Multisubunit Na H antiporter MnhC subunit
V060002_RS08900	COG0651	ATP synthesis coupled electron transport
V060002_RS08905	COG1863	multisubunit Na H antiporter MnhE subunit
V060002_RS08910	COG2212	antiporter activity
V060002_RS08915	COG1320	monovalent cation:proton antiporter activity
V060002_RS08925	COG0242	peptide deformylase activity
V060002_RS08935	COG0579	oxidoreductase
V060002_RS08975	COG2271	Major facilitator Superfamily
V060002_RS08980	COG0584	glycerophosphoryl diester phosphodiesterase
V060002_RS08990	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
V060002_RS09000	COG1609	Transcriptional regulator
V060002_RS09005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_RS09010	COG1879	ABC-type sugar transport system periplasmic component
V060002_RS09015	COG1172	Belongs to the binding-protein-dependent transport system permease family
V060002_RS09020	COG1129	ABC transporter
V060002_RS09025	COG1869	D-ribose catabolic process
V060002_RS09040	COG3501	Rhs element vgr protein
V060002_RS09040	COG3409	Peptidoglycan-binding domain 1 protein
V060002_RS09070	COG3829	transcription factor binding
V060002_RS09135	COG0564	pseudouridine synthase activity
V060002_RS09145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
V060002_RS09150	COG2200	EAL domain
V060002_RS09150	COG2771	luxR family
V060002_RS09160	COG0673	inositol 2-dehydrogenase activity
V060002_RS09165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
V060002_RS09200	COG1342	Belongs to the UPF0251 family
V060002_RS09210	COG1301	dicarboxylic acid transport
V060002_RS09235	COG2814	Major facilitator Superfamily
V060002_RS09240	COG0583	DNA-binding transcription factor activity
V060002_RS09245	COG5001	Diguanylate cyclase
V060002_RS09245	COG3300	MHYT domain
V060002_RS09250	COG0739	heme binding
V060002_RS09265	COG0659	secondary active sulfate transmembrane transporter activity
V060002_RS09270	COG3314	Sporulation integral membrane protein YlbJ
V060002_RS09290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
V060002_RS09295	COG0581	inorganic phosphate transmembrane transporter activity
V060002_RS09300	COG0573	inorganic phosphate transmembrane transporter activity
V060002_RS09305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
V060002_RS09335	COG1770	oligopeptidase
V060002_RS09340	COG0513	Belongs to the DEAD box helicase family
V060002_RS09350	COG1376	ErfK ybiS ycfS ynhG family protein
V060002_RS09350	COG1388	LysM domain
V060002_RS09355	COG0415	Belongs to the DNA photolyase family
V060002_RS09365	COG3272	Protein of unknown function (DUF1722)
V060002_RS09375	COG0813	purine-nucleoside phosphorylase activity
V060002_RS09400	COG1566	PFAM secretion protein HlyD family protein
V060002_RS09420	COG0786	glutamate:sodium symporter activity
V060002_RS09435	COG1999	signal sequence binding
V060002_RS09445	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
V060002_RS09450	COG0671	phosphoesterase, PA-phosphatase related
V060002_RS09495	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
V060002_RS09500	COG0471	metal ion transport
V060002_RS09530	COG4104	PAAR repeat-containing protein
V060002_RS09535	COG3501	Rhs element vgr protein
V060002_RS09550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
V060002_RS09555	COG1640	4-alpha-glucanotransferase
V060002_RS09560	COG0058	SHG alpha-glucan phosphorylase activity
V060002_RS09565	COG2909	trisaccharide binding
V060002_RS09585	COG2084	Dehydrogenase
V060002_RS09590	COG0217	transcriptional regulatory protein
V060002_RS09630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V060002_RS09635	COG1444	tRNA N-acetyltransferase activity
V060002_RS09670	COG0642	Histidine kinase
V060002_RS09675	COG2194	sulfuric ester hydrolase activity
V060002_RS09685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_RS09690	COG0601	transmembrane transport
V060002_RS09710	COG0643	Histidine kinase
V060002_RS09710	COG2198	Histidine kinase
V060002_RS09715	COG0835	chemotaxis
V060002_RS09720	COG0835	chemotaxis
V060002_RS09725	COG0840	transmembrane signaling receptor activity
V060002_RS09730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V060002_RS09755	COG0745	RESPONSE REGULATOR receiver
V060002_RS09795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
V060002_RS09820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
V060002_RS09855	COG1982	Orn Lys Arg decarboxylase major
V060002_RS09860	COG0531	amino acid
V060002_RS09875	COG1901	pseudouridine methyltransferase
V060002_RS09885	COG4221	oxidoreductase activity
V060002_RS09895	COG0840	transmembrane signaling receptor activity
V060002_RS09905	COG2910	NAD(P)H-binding
V060002_RS09935	COG0673	inositol 2-dehydrogenase activity
V060002_RS09940	COG3722	fumarate hydratase activity
V060002_RS09945	COG0246	Mannitol dehydrogenase
V060002_RS09950	COG2213	PTS system mannitol-specific
V060002_RS09950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_RS09960	COG0739	heme binding
V060002_RS09970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
V060002_RS09975	COG4597	amino acid ABC transporter
V060002_RS09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_RS09990	COG1126	abc transporter atp-binding protein
V060002_RS09995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V060002_RS10005	COG0840	transmembrane signaling receptor activity
V060002_RS10020	COG0840	transmembrane signaling receptor activity
V060002_RS10035	COG4580	involved in the transport of maltose and maltodextrins
V060002_RS10050	COG0363	glucosamine-6-phosphate deaminase activity
V060002_RS10075	COG2259	Doxx family
V060002_RS10080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
V060002_RS10085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
V060002_RS10095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
V060002_RS10100	COG3366	ferrous iron transmembrane transporter activity
V060002_RS10105	COG0700	Nucleoside recognition
V060002_RS10115	COG0697	spore germination
V060002_RS10120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V060002_RS10125	COG1764	response to oxidative stress
V060002_RS10130	COG1846	Transcriptional regulator
V060002_RS10150	COG2207	Transcriptional regulator
V060002_RS10155	COG1280	lysine exporter protein (LysE YggA)
V060002_RS10165	COG1902	pentaerythritol trinitrate reductase activity
V060002_RS10175	COG1132	(ABC) transporter
V060002_RS10185	COG1902	pentaerythritol trinitrate reductase activity
V060002_RS10195	COG0583	DNA-binding transcription factor activity
V060002_RS10200	COG0513	Belongs to the DEAD box helicase family
V060002_RS10210	COG0840	transmembrane signaling receptor activity
V060002_RS10220	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
V060002_RS10235	COG1620	l-lactate permease
V060002_RS10240	COG0583	DNA-binding transcription factor activity
V060002_RS10265	COG4172	Belongs to the ABC transporter superfamily
V060002_RS10275	COG1067	ATP-dependent peptidase activity
V060002_RS10280	COG0840	transmembrane signaling receptor activity
V060002_RS10290	COG2211	Major facilitator Superfamily
V060002_RS10300	COG3123	guanosine phosphorylase activity
V060002_RS10305	COG1741	Belongs to the pirin family
V060002_RS10315	COG5001	Diguanylate cyclase
V060002_RS10320	COG0583	DNA-binding transcription factor activity
V060002_RS10360	COG3706	GGDEF domain
V060002_RS10365	COG1846	Transcriptional regulator
V060002_RS10370	COG0835	chemotaxis
V060002_RS10370	COG0784	Response regulator, receiver
V060002_RS10375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V060002_RS10385	COG0393	Putative heavy-metal-binding
V060002_RS10400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_RS10405	COG3842	ATPase activity
V060002_RS10415	COG1175	transmembrane transport
V060002_RS10420	COG3833	ABC-type maltose transport systems, permease component
V060002_RS10435	COG1349	DNA-binding transcription factor activity
V060002_RS10440	COG2199	diguanylate cyclase activity
V060002_RS10470	COG1278	Cold shock
V060002_RS10475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V060002_RS10480	COG2354	Protein conserved in bacteria
V060002_RS10485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
V060002_RS10495	COG3152	Membrane
V060002_RS10505	COG0418	dihydroorotase activity
V060002_RS10515	COG0633	Ferredoxin
V060002_RS10515	COG3217	Mosc domain protein beta barrel domain protein
V060002_RS10515	COG0633	Ferredoxin
V060002_RS10515	COG3217	Mosc domain protein beta barrel domain protein
V060002_RS10550	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
V060002_RS10555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_RS10560	COG4558	Periplasmic binding protein
V060002_RS10565	COG0848	biopolymer transport protein
V060002_RS10570	COG0811	peptide transport
V060002_RS10575	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
V060002_RS10585	COG3721	Heme iron utilization protein
V060002_RS10590	COG0748	coenzyme F420 binding
V060002_RS10600	COG3835	regulator
V060002_RS10605	COG2610	gluconate transmembrane transporter activity
V060002_RS10610	COG1929	Belongs to the glycerate kinase type-1 family
V060002_RS10635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
V060002_RS10640	COG0363	glucosamine-6-phosphate deaminase activity
V060002_RS10645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
V060002_RS10650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
V060002_RS10655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
V060002_RS10675	COG0346	lactoylglutathione lyase activity
V060002_RS10705	COG1063	alcohol dehydrogenase
V060002_RS10745	COG0582	viral genome integration into host DNA
V060002_RS10755	COG0583	DNA-binding transcription factor activity
V060002_RS10760	COG3048	D-serine ammonia-lyase activity
V060002_RS10775	COG1294	oxidase, subunit
V060002_RS10780	COG1271	oxidase subunit
V060002_RS10785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
V060002_RS10790	COG1686	Belongs to the peptidase S11 family
V060002_RS10800	COG3047	cAMP biosynthetic process
V060002_RS10810	COG3227	Zinc metalloprotease (Elastase)
V060002_RS10820	COG2267	carboxylic ester hydrolase activity
V060002_RS10825	COG2067	long-chain fatty acid transport protein
V060002_RS10835	COG0366	Alpha amylase catalytic
V060002_RS10840	COG4989	oxidoreductase activity
V060002_RS10855	COG1136	(ABC) transporter
V060002_RS10860	COG1136	(ABC) transporter
V060002_RS10860	COG0577	efflux transmembrane transporter activity
V060002_RS10875	COG3275	phosphorelay sensor kinase activity
V060002_RS10880	COG3279	Response regulator of the LytR AlgR family
V060002_RS10895	COG0531	amino acid
V060002_RS10920	COG1765	OsmC-like protein
V060002_RS10925	COG1253	flavin adenine dinucleotide binding
V060002_RS10950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V060002_RS10970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V060002_RS10975	COG3186	Phenylalanine-4-hydroxylase
V060002_RS10985	COG0456	acetyltransferase
V060002_RS10990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
V060002_RS10995	COG0662	Cupin 2, conserved barrel domain protein
V060002_RS11000	COG0527	aspartate kinase activity
V060002_RS11010	COG0459	protein refolding
V060002_RS11015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
V060002_RS11020	COG2239	Acts as a magnesium transporter
V060002_RS11030	COG1166	arginine decarboxylase activity
V060002_RS11035	COG0010	Belongs to the arginase family
V060002_RS11045	COG3227	Zinc metalloprotease (Elastase)
V060002_RS11050	COG3397	chitin binding
V060002_RS11055	COG3046	protein related to deoxyribodipyrimidine photolyase
V060002_RS11065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
V060002_RS11080	COG0513	Belongs to the DEAD box helicase family
V060002_RS11090	COG1368	sulfuric ester hydrolase activity
V060002_RS11095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_RS11110	COG0546	phosphoglycolate phosphatase activity
V060002_RS11145	COG2003	Belongs to the UPF0758 family
V060002_RS11155	COG4409	exo-alpha-(2->6)-sialidase activity
V060002_RS11160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V060002_RS11165	COG1940	carbohydrate kinase activity
V060002_RS11180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
V060002_RS11185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
V060002_RS11190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
V060002_RS11195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
V060002_RS11200	COG1737	Transcriptional regulator
V060002_RS11205	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
V060002_RS11210	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
V060002_RS11230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
V060002_RS11250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
V060002_RS11270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
V060002_RS11275	COG0582	viral genome integration into host DNA
V060002_RS11280	COG0582	viral genome integration into host DNA
V060002_RS11295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_RS11305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
V060002_RS11305	COG3008	intermembrane lipid transfer
V060002_RS11310	COG2995	paraquat-inducible protein a
V060002_RS11315	COG0668	transmembrane transport
V060002_RS11340	COG1309	transcriptional regulator
V060002_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
V060002_RS11370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
V060002_RS11380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
V060002_RS11410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
V060002_RS11415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
V060002_RS11420	COG0297	glycogen (starch) synthase activity
V060002_RS11440	COG3070	regulator of competence-specific genes
V060002_RS11445	COG1609	Transcriptional regulator
V060002_RS11455	COG3381	protein complex oligomerization
V060002_RS11460	COG0745	RESPONSE REGULATOR receiver
V060002_RS11465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
V060002_RS11470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V060002_RS11480	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
V060002_RS11500	COG1032	radical SAM domain protein
V060002_RS11505	COG5001	Diguanylate cyclase
V060002_RS11510	COG0612	Peptidase, M16
V060002_RS11525	COG0583	DNA-binding transcription factor activity
V060002_RS11530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
V060002_RS11540	COG2350	Protein conserved in bacteria
V060002_RS11545	COG1607	acyl-coa hydrolase
V060002_RS11560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
V060002_RS11565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V060002_RS11580	COG2116	formate transmembrane transporter activity
V060002_RS11590	COG4459	periplasmic nitrate reductase
V060002_RS11595	COG3005	denitrification pathway
V060002_RS11600	COG0243	molybdopterin cofactor binding
V060002_RS11625	COG1227	inorganic diphosphatase activity
V060002_RS11640	COG4172	Belongs to the ABC transporter superfamily
V060002_RS11655	COG4168	peptide transport system, permease
V060002_RS11665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
V060002_RS11670	COG1842	Phage shock protein A
V060002_RS11685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_RS11700	COG2818	Glycosylase
V060002_RS11705	COG0626	cystathionine gamma-synthase activity
V060002_RS11720	COG0733	neurotransmitter:sodium symporter activity
V060002_RS11725	COG0564	pseudouridine synthase activity
V060002_RS11730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
V060002_RS11735	COG4136	ATPase activity
V060002_RS11740	COG4135	transport system, permease component
V060002_RS11745	COG4134	Bacterial extracellular solute-binding protein
V060002_RS11755	COG3313	Fe-S protein
V060002_RS11765	COG0842	Transport permease protein
V060002_RS11770	COG1131	(ABC) transporter
V060002_RS11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_RS11780	COG0814	amino acid
V060002_RS11790	COG2239	Acts as a magnesium transporter
V060002_RS11795	COG0784	Response regulator, receiver
V060002_RS11795	COG2205	protein histidine kinase activity
V060002_RS11810	COG4934	collagen metabolic process
V060002_RS11840	COG0840	transmembrane signaling receptor activity
V060002_RS11855	COG2203	Gaf domain
V060002_RS11855	COG3706	GGDEF domain
V060002_RS11855	COG4251	negative regulation of phosphorylation
V060002_RS11855	COG5001	Diguanylate cyclase
V060002_RS11860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
V060002_RS11880	COG1061	Type III restriction enzyme res subunit
V060002_RS11885	COG1187	pseudouridine synthase activity
V060002_RS11890	COG2814	Major facilitator Superfamily
V060002_RS11900	COG0702	epimerase
V060002_RS11905	COG0534	Mate efflux family protein
V060002_RS11910	COG4181	ATPase activity
V060002_RS11915	COG0577	efflux transmembrane transporter activity
V060002_RS11925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
V060002_RS11940	COG1748	Saccharopine dehydrogenase
V060002_RS11955	COG1538	Outer membrane efflux protein
V060002_RS11975	COG0583	DNA-binding transcription factor activity
V060002_RS11985	COG1451	nucleotide metabolic process
V060002_RS11990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
V060002_RS12000	COG3063	Type IV pilus biogenesis stability protein PilW
V060002_RS12005	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
V060002_RS12025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_RS12040	COG3290	protein histidine kinase activity
V060002_RS12045	COG4565	transcriptional regulatory protein
V060002_RS12055	COG0835	chemotaxis
V060002_RS12055	COG0784	Response regulator, receiver
V060002_RS12100	COG1085	galactose-1-phosphate uridylyltransferase
V060002_RS12105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
V060002_RS12110	COG2017	converts alpha-aldose to the beta-anomer
V060002_RS12120	COG2199	diguanylate cyclase activity
V060002_RS12120	COG2200	EAL domain
V060002_RS12150	COG0753	catalase activity
V060002_RS12170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
V060002_RS12180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
V060002_RS12225	COG1271	oxidase subunit
V060002_RS12230	COG1294	oxidase, subunit
V060002_RS12235	COG4591	ABC-type transport system involved in lipoprotein release permease component
V060002_RS12235	COG1136	(ABC) transporter
V060002_RS12240	COG0577	efflux transmembrane transporter activity
V060002_RS12240	COG1136	(ABC) transporter
V060002_RS12245	COG1136	(ABC) transporter
V060002_RS12245	COG0577	efflux transmembrane transporter activity
V060002_RS12265	COG0583	DNA-binding transcription factor activity
V060002_RS12275	COG2723	6-phospho-beta-galactosidase activity
V060002_RS12280	COG1609	Transcriptional regulator
V060002_RS12285	COG0251	oxidation-reduction process
V060002_RS12290	COG2731	YhcH YjgK YiaL family protein
V060002_RS12295	COG0584	glycerophosphoryl diester phosphodiesterase
V060002_RS12300	COG1349	DNA-binding transcription factor activity
V060002_RS12305	COG3842	ATPase activity
V060002_RS12310	COG0395	ABC-type sugar transport system, permease component
V060002_RS12315	COG1175	transmembrane transport
V060002_RS12330	COG0811	peptide transport
V060002_RS12335	COG0811	peptide transport
V060002_RS12340	COG0848	biopolymer transport protein
V060002_RS12345	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
V060002_RS12360	COG1793	dna ligase
V060002_RS12370	COG0534	Mate efflux family protein
V060002_RS12380	COG3001	Fructosamine kinase
V060002_RS12390	COG0791	NLP P60 protein
V060002_RS12395	COG0840	transmembrane signaling receptor activity
V060002_RS12405	COG3148	PFAM DTW domain containing protein
V060002_RS12410	COG1940	carbohydrate kinase activity
V060002_RS12445	COG0746	molybdenum cofactor guanylyltransferase activity
V060002_RS12450	COG3842	ATPase activity
V060002_RS12455	COG4662	Binding-protein-dependent transport system inner membrane component
V060002_RS12465	COG2204	response regulator
V060002_RS12470	COG3852	Histidine kinase
V060002_RS12475	COG0488	(ABC) transporter
V060002_RS12480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
V060002_RS12510	COG3383	formate dehydrogenase (NAD+) activity
V060002_RS12510	COG0243	molybdopterin cofactor binding
V060002_RS12515	COG0437	4 iron, 4 sulfur cluster binding
V060002_RS12530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
V060002_RS12535	COG1666	GTP binding
V060002_RS12540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V060002_RS12555	COG2996	Protein conserved in bacteria
V060002_RS12565	COG3008	intermembrane lipid transfer
V060002_RS12570	COG2995	paraquat-inducible protein a
V060002_RS12575	COG1132	(ABC) transporter
V060002_RS12580	COG1956	GAF domain-containing protein
V060002_RS12585	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
V060002_RS12600	COG0308	aminopeptidase N
V060002_RS12615	COG0167	dihydroorotate dehydrogenase activity
V060002_RS12625	COG0116	Belongs to the methyltransferase superfamily
V060002_RS12625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V060002_RS12635	COG0488	(ABC) transporter
V060002_RS12650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
V060002_RS12655	COG1067	ATP-dependent peptidase activity
V060002_RS12660	COG3120	sequence-specific DNA binding
V060002_RS12675	COG1073	alpha beta
V060002_RS12675	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
V060002_RS12675	COG3064	Membrane
V060002_RS12680	COG2994	toxin metabolic process
V060002_RS12705	COG2205	protein histidine kinase activity
V060002_RS12705	COG0784	Response regulator, receiver
V060002_RS12720	COG3278	Belongs to the heme-copper respiratory oxidase family
V060002_RS12735	COG2010	Cytochrome c
V060002_RS12745	COG2217	Heavy metal translocating P-type atpase
V060002_RS12760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
V060002_RS12765	COG0589	response to stress
V060002_RS12790	COG3842	ATPase activity
V060002_RS12800	COG1177	transmembrane transport
V060002_RS12810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V060002_RS12825	COG1115	amino acid carrier protein
V060002_RS12830	COG1280	lysine exporter protein (LysE YggA)
V060002_RS12845	COG3675	Pfam Lipase (class 3)
V060002_RS12855	COG3501	Rhs element vgr protein
V060002_RS12865	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
V060002_RS12875	COG2814	Major facilitator Superfamily
V060002_RS12880	COG1566	PFAM secretion protein HlyD family protein
V060002_RS12885	COG1538	Outer membrane efflux protein
V060002_RS12895	COG0513	Belongs to the DEAD box helicase family
V060002_RS12905	COG0840	transmembrane signaling receptor activity
V060002_RS12910	COG3290	protein histidine kinase activity
V060002_RS12910	COG0840	transmembrane signaling receptor activity
V060002_RS12915	COG0835	chemotaxis
V060002_RS12920	COG2201	protein-glutamate methylesterase activity
V060002_RS12930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
V060002_RS12935	COG0643	Histidine kinase
V060002_RS12935	COG0784	Response regulator, receiver
V060002_RS12935	COG2198	Histidine kinase
V060002_RS12940	COG2198	Histidine kinase
V060002_RS12940	COG0643	Histidine kinase
V060002_RS12950	COG0745	RESPONSE REGULATOR receiver
V060002_RS12965	COG0415	Belongs to the DNA photolyase family
V060002_RS12970	COG0477	Major facilitator Superfamily
V060002_RS12975	COG0583	DNA-binding transcription factor activity
V060002_RS12985	COG0095	Lipoate-protein ligase
V060002_RS12990	COG0443	Heat shock 70 kDa protein
V060002_RS13000	COG1643	Atp-dependent helicase
V060002_RS13040	COG0443	Heat shock 70 kDa protein
V060002_RS13045	COG0443	Heat shock 70 kDa protein
V060002_RS13050	COG3706	GGDEF domain
V060002_RS13080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
V060002_RS13085	COG0602	queuosine metabolic process
V060002_RS13095	COG0561	phosphatase activity
V060002_RS13105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_RS13110	COG4597	amino acid ABC transporter
V060002_RS13115	COG0765	amino acid transport
V060002_RS13120	COG1126	abc transporter atp-binding protein
V060002_RS13125	COG0670	Belongs to the BI1 family
V060002_RS13130	COG2920	part of a sulfur-relay system
V060002_RS13135	COG1254	Belongs to the acylphosphatase family
V060002_RS13140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
V060002_RS13145	COG3706	GGDEF domain
V060002_RS13165	COG3437	response regulator, receiver
V060002_RS13170	COG0625	glutathione transferase activity
V060002_RS13180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
V060002_RS13190	COG2195	Cleaves the N-terminal amino acid of tripeptides
V060002_RS13220	COG0372	Belongs to the citrate synthase family
V060002_RS13225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
V060002_RS13265	COG1129	ABC transporter
V060002_RS13295	COG0745	RESPONSE REGULATOR receiver
V060002_RS13300	COG2205	protein histidine kinase activity
V060002_RS13305	COG3713	MltA-interacting MipA family protein
V060002_RS13310	COG2990	Protein conserved in bacteria
V060002_RS13320	COG4191	Histidine kinase
V060002_RS13320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
V060002_RS13325	COG0471	metal ion transport
V060002_RS13335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V060002_RS13355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_RS13365	COG3768	UPF0283 membrane protein
V060002_RS13370	COG3106	COG3106 Predicted ATPase
V060002_RS13385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
V060002_RS13390	COG0494	nUDIX hydrolase
V060002_RS13395	COG0814	amino acid
V060002_RS13400	COG1760	l-serine dehydratase
V060002_RS13405	COG0720	synthase
V060002_RS13415	COG0017	Asparaginyl-tRNA synthetase
V060002_RS13420	COG0351	phosphomethylpyrimidine kinase
V060002_RS13425	COG3437	response regulator, receiver
V060002_RS13425	COG2770	Histidine kinase
V060002_RS13435	COG1448	Aminotransferase
V060002_RS13450	COG0840	transmembrane signaling receptor activity
V060002_RS13455	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
V060002_RS13460	COG2943	transferase activity, transferring hexosyl groups
V060002_RS13465	COG1609	Transcriptional regulator
V060002_RS13475	COG1486	melibiose metabolic process
V060002_RS13480	COG1447	Phosphotransferase system cellobiose-specific component IIA
V060002_RS13490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
V060002_RS13495	COG0726	polysaccharide deacetylase
V060002_RS13500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
V060002_RS13505	COG1846	Transcriptional regulator
V060002_RS13535	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
V060002_RS13550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
V060002_RS13555	COG3108	Peptidase M15
V060002_RS13560	COG2989	Protein conserved in bacteria
V060002_RS13585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
V060002_RS13595	COG2814	Major facilitator Superfamily
V060002_RS13605	COG1054	Belongs to the UPF0176 family
V060002_RS13615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
V060002_RS13620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V060002_RS13625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
V060002_RS13680	COG4139	cobalamin transport
V060002_RS13700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
V060002_RS13705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
V060002_RS13715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
V060002_RS13720	COG1823	symporter activity
V060002_RS13725	COG2925	Exonuclease
V060002_RS13730	COG1380	Effector of murein hydrolase LrgA
V060002_RS13735	COG1346	cytolysis
V060002_RS13775	COG0776	regulation of translation
V060002_RS13780	COG0072	phenylalanine-tRNA ligase activity
V060002_RS13780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_RS13785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
V060002_RS13825	COG0322	excinuclease ABC activity
V060002_RS13830	COG2197	response regulator
V060002_RS13835	COG0417	DNA replication proofreading
V060002_RS13840	COG5001	Diguanylate cyclase
V060002_RS13850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
V060002_RS13855	COG3099	Belongs to the UPF0263 family
V060002_RS13870	COG1228	amidohydrolase
V060002_RS13875	COG0010	Belongs to the arginase family
V060002_RS13880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
V060002_RS13885	COG2986	histidine ammonia-lyase
V060002_RS13905	COG0247	lactate metabolic process
V060002_RS13905	COG0277	FAD linked oxidase domain protein
V060002_RS13920	COG2885	chlorophyll binding
V060002_RS13940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
V060002_RS13950	COG0281	malic enzyme
V060002_RS13960	COG2949	membrane
V060002_RS13965	COG3706	GGDEF domain
V060002_RS13970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
V060002_RS13980	COG0492	ferredoxin-NADP+ reductase activity
V060002_RS13985	COG4988	ABC transporter
V060002_RS13990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
V060002_RS13995	COG1187	pseudouridine synthase activity
V060002_RS14000	COG0009	L-threonylcarbamoyladenylate synthase
V060002_RS14005	COG0613	PHP domain protein
V060002_RS14015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
V060002_RS14020	COG0512	Glutamine amidotransferase of anthranilate synthase
V060002_RS14025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
V060002_RS14030	COG0134	indole-3-glycerol-phosphate synthase activity
V060002_RS14030	COG0135	phosphoribosylanthranilate isomerase activity
V060002_RS14035	COG0133	tryptophan synthase activity
V060002_RS14040	COG0159	tryptophan synthase activity
V060002_RS14050	COG1435	thymidine kinase activity
V060002_RS14055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
V060002_RS14060	COG1801	Protein of unknown function DUF72
V060002_RS14065	COG4106	trans-aconitate 2-methyltransferase activity
V060002_RS14070	COG0500	methyltransferase
V060002_RS14075	COG0189	ligase activity
V060002_RS14075	COG4067	protein conserved in archaea
V060002_RS14090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
V060002_RS14100	COG3852	Histidine kinase
V060002_RS14115	COG3070	regulator of competence-specific genes
V060002_RS14125	COG2431	L-lysine efflux transmembrane transporter activity
V060002_RS14135	COG0076	glutamate decarboxylase activity
V060002_RS14140	COG1737	Transcriptional regulator
V060002_RS14145	COG1012	belongs to the aldehyde dehydrogenase family
V060002_RS14145	COG1454	alcohol dehydrogenase
V060002_RS14150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
V060002_RS14155	COG3273	potassium ion transport
V060002_RS14155	COG2985	domain, Protein
V060002_RS14160	COG0542	response to heat
V060002_RS14165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
V060002_RS14170	COG1278	Cold shock
V060002_RS14180	COG1187	pseudouridine synthase activity
V060002_RS14185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
V060002_RS14185	COG0140	phosphoribosyl-ATP diphosphatase activity
V060002_RS14190	COG0107	imidazoleglycerol-phosphate synthase activity
V060002_RS14195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
V060002_RS14200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
V060002_RS14205	COG0131	Imidazoleglycerol-phosphate dehydratase
V060002_RS14205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V060002_RS14210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
V060002_RS14215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
V060002_RS14220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
V060002_RS14225	COG1757	Na H antiporter
V060002_RS14230	COG2916	Histone family protein nucleoid-structuring protein H-NS
V060002_RS14235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
V060002_RS14240	COG0482	sulfurtransferase activity
V060002_RS14245	COG2915	High frequency lysogenization protein hflD homolog
V060002_RS14250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
V060002_RS14260	COG2268	Band 7 protein
V060002_RS14270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
V060002_RS14285	COG0300	oxidoreductase activity
V060002_RS14295	COG0501	Belongs to the peptidase M48B family
V060002_RS14305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
V060002_RS14310	COG2226	methyltransferase
V060002_RS14315	COG0156	8-amino-7-oxononanoate synthase activity
V060002_RS14320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
V060002_RS14325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
V060002_RS14330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
V060002_RS14335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
V060002_RS14340	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
V060002_RS14350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V060002_RS14355	COG2199	diguanylate cyclase activity
V060002_RS14355	COG2203	Gaf domain
V060002_RS14365	COG4120	Belongs to the binding-protein-dependent transport system permease family
V060002_RS14375	COG4628	conserved protein (DUF2132)
V060002_RS14380	COG3092	negative regulation of chromosome organization
V060002_RS14385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
V060002_RS14390	COG0857	belongs to the CobB CobQ family
V060002_RS14390	COG0280	phosphate acetyltransferase
V060002_RS14395	COG0435	Glutathione S-transferase
V060002_RS14400	COG4608	Belongs to the ABC transporter superfamily
V060002_RS14405	COG0444	Belongs to the ABC transporter superfamily
V060002_RS14410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_RS14415	COG0601	transmembrane transport
V060002_RS14435	COG2204	response regulator
V060002_RS14440	COG3300	MHYT domain
V060002_RS14440	COG5001	Diguanylate cyclase
V060002_RS14445	COG4191	Histidine kinase
V060002_RS14450	COG5002	protein histidine kinase activity
V060002_RS14460	COG2201	protein-glutamate methylesterase activity
V060002_RS14475	COG0009	L-threonylcarbamoyladenylate synthase
V060002_RS14495	COG1881	PFAM PEBP family protein
V060002_RS14520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V060002_RS14525	COG0640	Transcriptional regulator
V060002_RS14535	COG3706	GGDEF domain
V060002_RS14555	COG1946	Acyl-CoA thioesterase
V060002_RS14560	COG1522	sequence-specific DNA binding
V060002_RS14570	COG0616	signal peptide processing
V060002_RS14575	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_RS14580	COG2983	Belongs to the UPF0260 family
V060002_RS14590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
V060002_RS14595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
V060002_RS14605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
V060002_RS14610	COG2832	Protein of unknown function (DUF454)
V060002_RS14620	COG0745	RESPONSE REGULATOR receiver
V060002_RS14625	COG0583	DNA-binding transcription factor activity
V060002_RS14630	COG0778	Nitroreductase
V060002_RS14635	COG1024	Enoyl-CoA hydratase
V060002_RS14635	COG1250	3-hydroxyacyl-CoA dehydrogenase
V060002_RS14640	COG0183	Belongs to the thiolase family
V060002_RS14660	COG2067	long-chain fatty acid transport protein
V060002_RS14670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
V060002_RS14675	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
V060002_RS14680	COG2982	Protein involved in outer membrane biogenesis
V060002_RS14685	COG0572	uridine kinase
V060002_RS14695	COG0489	protein tyrosine kinase activity
V060002_RS14700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_RS14700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
V060002_RS14710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
V060002_RS14725	COG0517	IMP dehydrogenase activity
V060002_RS14725	COG0617	tRNA 3'-terminal CCA addition
V060002_RS14725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
V060002_RS14730	COG2199	diguanylate cyclase activity
V060002_RS14735	COG0314	molybdopterin synthase activity
V060002_RS14740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
V060002_RS14745	COG0315	cyclic pyranopterin monophosphate synthase activity
V060002_RS14750	COG0521	Mo-molybdopterin cofactor biosynthetic process
V060002_RS14755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
V060002_RS14760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
V060002_RS14765	COG2198	Histidine kinase
V060002_RS14770	COG2204	response regulator
V060002_RS14780	COG0556	nucleotide-excision repair
V060002_RS14790	COG4657	Part of a membrane complex involved in electron transport
V060002_RS14795	COG2878	Part of a membrane complex involved in electron transport
V060002_RS14800	COG4656	Part of a membrane complex involved in electron transport
V060002_RS14820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
V060002_RS14825	COG0346	lactoylglutathione lyase activity
V060002_RS14840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
V060002_RS14845	COG2056	Na+-H+ antiporter family
V060002_RS14850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
V060002_RS14855	COG1286	toxin biosynthetic process
V060002_RS14860	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
V060002_RS14865	COG0285	dihydrofolate synthase activity
V060002_RS14870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
V060002_RS14875	COG0101	tRNA pseudouridine synthase activity
V060002_RS14890	COG1263	PTS System
V060002_RS14890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_RS14890	COG2190	(PTS) system
V060002_RS14895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
V060002_RS14900	COG1940	carbohydrate kinase activity
V060002_RS14900	COG1846	Transcriptional regulator
V060002_RS14905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
V060002_RS14905	COG4651	solute:proton antiporter activity
V060002_RS14910	COG0367	asparagine synthase
V060002_RS14925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
V060002_RS14930	COG0563	adenylate kinase activity
V060002_RS14935	COG0326	Molecular chaperone. Has ATPase activity
V060002_RS14955	COG0622	Phosphoesterase
V060002_RS14960	COG1090	epimerase
V060002_RS14965	COG0300	oxidoreductase activity
V060002_RS14975	COG3118	belongs to the thioredoxin family
V060002_RS14985	COG0330	HflC and HflK could
V060002_RS14990	COG1585	Membrane protein implicated in regulation of membrane protease activity
V060002_RS14995	COG0789	Transcriptional regulator
V060002_RS15015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
V060002_RS15020	COG3115	cell septum assembly
V060002_RS15025	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
V060002_RS15030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
V060002_RS15040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
V060002_RS15050	COG2190	(PTS) system
V060002_RS15055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
V060002_RS15060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
V060002_RS15065	COG1702	phosphate starvation-inducible protein PhoH
V060002_RS15075	COG4535	Mg2 and Co2 transporter CorC
V060002_RS15080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
V060002_RS15085	COG2888	peptidyl-tyrosine sulfation
V060002_RS15090	COG0495	leucyl-tRNA aminoacylation
V060002_RS15095	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
V060002_RS15100	COG1466	dna polymerase III delta subunit
V060002_RS15105	COG0799	negative regulation of ribosome biogenesis
V060002_RS15110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
V060002_RS15115	COG0768	penicillin binding
V060002_RS15120	COG0772	Belongs to the SEDS family
V060002_RS15125	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
V060002_RS15130	COG1686	Belongs to the peptidase S11 family
V060002_RS15135	COG2921	Belongs to the UPF0250 family
V060002_RS15140	COG0321	lipoyl(octanoyl) transferase activity
V060002_RS15145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
V060002_RS15155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
V060002_RS15180	COG1596	polysaccharide export
V060002_RS15190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
V060002_RS15220	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
V060002_RS15230	COG0438	transferase activity, transferring glycosyl groups
V060002_RS15240	COG1045	serine acetyltransferase
V060002_RS15260	COG0110	maltose O-acetyltransferase activity
V060002_RS15265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
V060002_RS15270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
V060002_RS15275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
V060002_RS15280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V060002_RS15310	COG0366	Alpha amylase catalytic
V060002_RS15315	COG1263	PTS System
V060002_RS15315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_RS15320	COG1609	Transcriptional regulator
V060002_RS15325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
V060002_RS15330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
V060002_RS15335	COG2011	ABC-type metal ion transport system permease component
V060002_RS15340	COG1464	Belongs to the NlpA lipoprotein family
V060002_RS15345	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
V060002_RS15355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V060002_RS15355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
V060002_RS15370	COG1611	Belongs to the LOG family
V060002_RS15375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
V060002_RS15380	COG2363	Small membrane protein
V060002_RS15385	COG0583	DNA-binding transcription factor activity
V060002_RS15390	COG0301	tRNA thio-modification
V060002_RS15390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
V060002_RS15400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
V060002_RS15405	COG1722	exodeoxyribonuclease VII activity
V060002_RS15410	COG0142	geranyltranstransferase activity
V060002_RS15415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
V060002_RS15420	COG0564	pseudouridine synthase activity
V060002_RS15425	COG3098	single-species biofilm formation
V060002_RS15440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
V060002_RS15450	COG1671	Belongs to the UPF0178 family
V060002_RS15455	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
V060002_RS15460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
V060002_RS15465	COG0254	rRNA binding
V060002_RS15470	COG1720	tRNA m6t6A37 methyltransferase activity
V060002_RS15475	COG0442	prolyl-tRNA aminoacylation
V060002_RS15505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
V060002_RS15505	COG0047	phosphoribosylformylglycinamidine synthase activity
V060002_RS15515	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
V060002_RS15525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
V060002_RS15550	COG4968	Prepilin-type N-terminal cleavage methylation domain
V060002_RS15560	COG0484	heat shock protein binding
V060002_RS15565	COG0443	Heat shock 70 kDa protein
V060002_RS15570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
V060002_RS15575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
V060002_RS15580	COG0497	DNA recombination
V060002_RS15585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V060002_RS15590	COG2914	Belongs to the UPF0125 (RnfH) family
V060002_RS15595	COG2867	negative regulation of translational initiation
V060002_RS15600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
V060002_RS15610	COG0582	viral genome integration into host DNA
V060002_RS15620	COG0582	viral genome integration into host DNA
V060002_RS15625	COG3064	Membrane
V060002_RS15635	COG0739	heme binding
V060002_RS15650	COG0840	transmembrane signaling receptor activity
V060002_RS15655	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
V060002_RS15660	COG2207	Transcriptional regulator
V060002_RS15670	COG1459	type II secretion system
V060002_RS15675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_RS15695	COG4796	Type ii and iii secretion system protein
V060002_RS15710	COG2165	general secretion pathway protein
V060002_RS15720	COG3710	Transcriptional regulator
V060002_RS15725	COG0840	transmembrane signaling receptor activity
V060002_RS15730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
V060002_RS15750	COG1012	belongs to the aldehyde dehydrogenase family
V060002_RS15815	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
V060002_RS15820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
V060002_RS15825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
V060002_RS15845	COG3051	citrate lyase alpha subunit
V060002_RS15850	COG2301	Belongs to the HpcH HpaI aldolase family
V060002_RS15860	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
V060002_RS15870	COG3630	sodium ion export across plasma membrane
V060002_RS15875	COG0511	ligase activity, forming carbon-carbon bonds
V060002_RS15875	COG5016	pyruvate
V060002_RS15880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
V060002_RS15890	COG4565	transcriptional regulatory protein
V060002_RS15905	COG0583	DNA-binding transcription factor activity
V060002_RS15915	COG1115	amino acid carrier protein
V060002_RS15920	COG2015	COG2015, Alkyl sulfatase and related hydrolases
V060002_RS15925	COG0583	DNA-binding transcription factor activity
V060002_RS15935	COG1120	ATPase activity
V060002_RS15940	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_RS15945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
V060002_RS15950	COG4592	Periplasmic binding protein
V060002_RS15960	COG1028	Short-chain dehydrogenase reductase Sdr
V060002_RS15965	COG1169	isochorismate synthase
V060002_RS15970	COG1021	2,3-dihydroxybenzoate-AMP ligase
V060002_RS15975	COG1535	isochorismatase
V060002_RS15975	COG3433	isochorismatase activity
V060002_RS15980	COG1584	GPR1 FUN34 yaaH family protein
V060002_RS15990	COG0519	Catalyzes the synthesis of GMP from XMP
V060002_RS15990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
V060002_RS15995	COG0516	GMP reductase activity
V060002_RS15995	COG0517	IMP dehydrogenase activity
V060002_RS16000	COG1570	exodeoxyribonuclease VII activity
V060002_RS16015	COG1160	GTP binding
V060002_RS16020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V060002_RS16025	COG2976	Protein conserved in bacteria
V060002_RS16030	COG0124	histidyl-tRNA synthetase
V060002_RS16035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
V060002_RS16045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
V060002_RS16050	COG0105	UTP biosynthetic process
V060002_RS16055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
V060002_RS16060	COG2975	iron-sulfur cluster assembly
V060002_RS16065	COG0633	Ferredoxin
V060002_RS16070	COG0443	Heat shock 70 kDa protein
V060002_RS16075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
V060002_RS16085	COG0822	iron-sulfur transferase activity
V060002_RS16090	COG1104	cysteine desulfurase activity
V060002_RS16095	COG1959	2 iron, 2 sulfur cluster binding
V060002_RS16105	COG0483	inositol monophosphate 1-phosphatase activity
V060002_RS16110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_RS16115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
V060002_RS16120	COG1862	Preprotein translocase
V060002_RS16140	COG0517	IMP dehydrogenase activity
V060002_RS16150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
V060002_RS16155	COG0583	DNA-binding transcription factor activity
V060002_RS16160	COG0450	alkyl hydroperoxide reductase
V060002_RS16165	COG3142	Participates in the control of copper homeostasis
V060002_RS16180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
V060002_RS16185	COG0581	inorganic phosphate transmembrane transporter activity
V060002_RS16195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
V060002_RS16200	COG0248	Ppx GppA phosphatase
V060002_RS16210	COG5002	protein histidine kinase activity
V060002_RS16215	COG0745	RESPONSE REGULATOR receiver
V060002_RS16225	COG0826	peptidase U32
V060002_RS16230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
V060002_RS16270	COG0542	response to heat
V060002_RS16280	COG0564	pseudouridine synthase activity
V060002_RS16285	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
V060002_RS16290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
V060002_RS16295	COG1605	Chorismate mutase
V060002_RS16295	COG0077	Prephenate dehydratase
V060002_RS16300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
V060002_RS16305	COG5001	Diguanylate cyclase
V060002_RS16315	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
V060002_RS16325	COG0488	(ABC) transporter
V060002_RS16335	COG1605	Chorismate mutase
V060002_RS16335	COG0287	Prephenate dehydrogenase
V060002_RS16340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
V060002_RS16345	COG3275	phosphorelay sensor kinase activity
V060002_RS16350	COG3279	Response regulator of the LytR AlgR family
V060002_RS16360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
V060002_RS16365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
V060002_RS16380	COG1966	Carbon starvation protein
V060002_RS16385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
V060002_RS16390	COG1047	Peptidyl-prolyl cis-trans
V060002_RS16405	COG0196	riboflavin kinase activity
V060002_RS16410	COG0728	peptidoglycan biosynthetic process
V060002_RS16415	COG0268	Binds directly to 16S ribosomal RNA
V060002_RS16420	COG0640	Transcriptional regulator
V060002_RS16425	COG0583	DNA-binding transcription factor activity
V060002_RS16430	COG1283	sodium-dependent phosphate transmembrane transporter activity
V060002_RS16440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
V060002_RS16445	COG0730	response to heat
V060002_RS16450	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
V060002_RS16455	COG0494	nUDIX hydrolase
V060002_RS16465	COG0667	Aldo Keto reductase
V060002_RS16475	COG2204	response regulator
V060002_RS16480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
V060002_RS16500	COG0513	Belongs to the DEAD box helicase family
V060002_RS16525	COG3153	acetyltransferase
V060002_RS16530	COG3154	lipid carrier protein
V060002_RS16540	COG0826	peptidase U32
V060002_RS16545	COG0826	peptidase U32
V060002_RS16570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
V060002_RS16580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
V060002_RS16585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
V060002_RS16590	COG0195	Participates in both transcription termination and antitermination
V060002_RS16595	COG0779	Required for maturation of 30S ribosomal subunits
V060002_RS16610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V060002_RS16625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
V060002_RS16630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
V060002_RS16635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
V060002_RS16640	COG1534	Rna-binding protein
V060002_RS16645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
V060002_RS16650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
V060002_RS16655	COG2027	D-alanyl-D-alanine carboxypeptidase
V060002_RS16660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V060002_RS16665	COG0739	heme binding
V060002_RS16680	COG0316	Belongs to the HesB IscA family
V060002_RS16685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
V060002_RS16690	COG0628	permease
V060002_RS16695	COG2813	Specifically methylates the guanine in position
V060002_RS16700	COG0784	Response regulator, receiver
V060002_RS16700	COG2205	protein histidine kinase activity
V060002_RS16710	COG0747	negative chemotaxis
V060002_RS16715	COG0601	transmembrane transport
V060002_RS16720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_RS16725	COG0444	Belongs to the ABC transporter superfamily
V060002_RS16730	COG4608	Belongs to the ABC transporter superfamily
V060002_RS16740	COG2971	BadF BadG BcrA BcrD
V060002_RS16760	COG3842	ATPase activity
V060002_RS16770	COG1840	ABC-type Fe3 transport system, periplasmic component
V060002_RS16775	COG0004	ammonium transporteR
V060002_RS16780	COG0347	Belongs to the P(II) protein family
V060002_RS16785	COG3112	Uncharacterised protein family (UPF0231)
V060002_RS16790	COG1049	propionate catabolic process, 2-methylcitrate cycle
V060002_RS16795	COG1752	Esterase of the alpha-beta hydrolase superfamily
V060002_RS16800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
V060002_RS16805	COG1643	Atp-dependent helicase
V060002_RS16815	COG1489	DNA binding
V060002_RS16825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
V060002_RS16835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
V060002_RS16840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
V060002_RS16845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
V060002_RS16850	COG0842	Transport permease protein
V060002_RS16855	COG1131	(ABC) transporter
V060002_RS16860	COG0659	secondary active sulfate transmembrane transporter activity
V060002_RS16865	COG0288	reversible hydration of carbon dioxide
V060002_RS16885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
V060002_RS16890	COG3107	peptidoglycan biosynthetic process
V060002_RS16895	COG0792	nuclease activity
V060002_RS16900	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
V060002_RS16905	COG2823	Periplasmic or secreted lipoprotein
V060002_RS16910	COG2969	positive regulation of protein catabolic process
V060002_RS16915	COG0625	glutathione transferase activity
V060002_RS16920	COG2857	Cytochrome c1
V060002_RS16925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
V060002_RS16930	COG0723	plastoquinol--plastocyanin reductase activity
V060002_RS16935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
V060002_RS16940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
V060002_RS16945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
V060002_RS16955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V060002_RS16960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
V060002_RS16965	COG0335	large ribosomal subunit rRNA binding
V060002_RS16970	COG0336	Belongs to the RNA methyltransferase TrmD family
V060002_RS16975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
V060002_RS16980	COG0228	four-way junction DNA binding
V060002_RS16985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
V060002_RS16990	COG4137	Cytochrome C assembly protein
V060002_RS16995	COG4536	flavin adenine dinucleotide binding
V060002_RS17000	COG1854	S-ribosylhomocysteine lyase activity
V060002_RS17005	COG2918	glutathione biosynthetic process
V060002_RS17010	COG0612	Peptidase, M16
V060002_RS17015	COG1238	metal cluster binding
V060002_RS17025	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
V060002_RS17030	COG0511	ligase activity, forming carbon-carbon bonds
V060002_RS17030	COG5016	pyruvate
V060002_RS17035	COG3630	sodium ion export across plasma membrane
V060002_RS17080	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
V060002_RS17085	COG0527	aspartate kinase activity
V060002_RS17090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
V060002_RS17100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
V060002_RS17110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
V060002_RS17115	COG4208	sulfate ABC transporter
V060002_RS17135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
V060002_RS17140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
V060002_RS17150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
V060002_RS17155	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
V060002_RS17160	COG0585	pseudouridine synthase activity
V060002_RS17165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
V060002_RS17170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
V060002_RS17175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
V060002_RS17180	COG1968	undecaprenyl-diphosphatase activity
V060002_RS17185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
V060002_RS17190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
V060002_RS17200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
V060002_RS17210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
V060002_RS17215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
V060002_RS17220	COG1610	YqeY-like protein
V060002_RS17225	COG0358	DNA primase activity
V060002_RS17240	COG0582	viral genome integration into host DNA
V060002_RS17245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
V060002_RS17250	COG0840	transmembrane signaling receptor activity
V060002_RS17255	COG2207	Transcriptional regulator
V060002_RS17260	COG0840	transmembrane signaling receptor activity
V060002_RS17270	COG2003	Belongs to the UPF0758 family
V060002_RS17305	COG0739	heme binding
V060002_RS17315	COG4969	Belongs to the N-Me-Phe pilin family
V060002_RS17330	COG0328	RNA-DNA hybrid ribonuclease activity
V060002_RS17380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
V060002_RS17385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
V060002_RS17390	COG1349	DNA-binding transcription factor activity
V060002_RS17410	COG1279	arginine transmembrane transporter activity
V060002_RS17415	COG0668	transmembrane transport
V060002_RS17425	COG0191	fructose-bisphosphate aldolase activity
V060002_RS17430	COG0126	phosphoglycerate kinase activity
V060002_RS17435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
V060002_RS17440	COG4771	TonB-dependent receptor
V060002_RS17445	COG0583	DNA-binding transcription factor activity
V060002_RS17450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
V060002_RS17455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
V060002_RS17465	COG2356	endonuclease I
V060002_RS17470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
V060002_RS17475	COG0189	ligase activity
V060002_RS17480	COG1678	Uncharacterized ACR, COG1678
V060002_RS17485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
V060002_RS17490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
V060002_RS17510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
V060002_RS17515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
V060002_RS17520	COG0762	integral membrane protein
V060002_RS17525	COG1872	DUF167
V060002_RS17535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
V060002_RS17540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
V060002_RS17545	COG2066	Belongs to the glutaminase family
V060002_RS17555	COG1194	a g-specific adenine glycosylase
V060002_RS17560	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
V060002_RS17565	COG0741	lytic transglycosylase activity
V060002_RS17620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
V060002_RS17625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
V060002_RS17630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
V060002_RS17635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
V060002_RS17640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
V060002_RS17645	COG2967	ApaG domain
V060002_RS17650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
V060002_RS17660	COG3610	response to peptide
V060002_RS17665	COG2966	Psort location CytoplasmicMembrane, score
V060002_RS17670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
V060002_RS17675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
V060002_RS17680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
V060002_RS17685	COG0142	geranyltranstransferase activity
V060002_RS17695	COG0039	L-malate dehydrogenase activity
V060002_RS17700	COG1438	arginine binding
V060002_RS17710	COG2358	TRAP transporter, solute receptor (TAXI family
V060002_RS17720	COG0589	response to stress
V060002_RS17740	COG2235	arginine
V060002_RS17745	COG0312	modulator of DNA gyrase
V060002_RS17750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
V060002_RS17755	COG3164	Protein of unknown function
V060002_RS17765	COG0424	maF-like protein
V060002_RS17770	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
V060002_RS17775	COG1792	Involved in formation and maintenance of cell shape
V060002_RS17780	COG1077	Cell shape determining protein MreB Mrl
V060002_RS17810	COG2165	general secretion pathway protein
V060002_RS17815	COG2165	general secretion pathway protein
V060002_RS17825	COG1459	type II secretion system
V060002_RS17830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
V060002_RS17840	COG3267	Type II secretory pathway component ExeA
V060002_RS17840	COG3409	Peptidoglycan-binding domain 1 protein
V060002_RS17865	COG2200	EAL domain
V060002_RS17865	COG2199	diguanylate cyclase activity
V060002_RS17870	COG0629	single-stranded DNA binding
V060002_RS17885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
V060002_RS17895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
V060002_RS17900	COG0527	aspartate kinase activity
V060002_RS17905	COG1410	methionine synthase
V060002_RS17905	COG0646	methionine synthase
V060002_RS17975	COG0175	sulfate reduction
V060002_RS17985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
V060002_RS18010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V060002_RS18015	COG0735	belongs to the Fur family
V060002_RS18035	COG0432	Pfam Uncharacterised protein family UPF0047
V060002_RS18040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
V060002_RS18055	COG0359	binds to the 23S rRNA
V060002_RS18060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
V060002_RS18065	COG2965	DNA replication, synthesis of RNA primer
V060002_RS18070	COG0360	Binds together with S18 to 16S ribosomal RNA
V060002_RS18080	COG2906	2 iron, 2 sulfur cluster binding
V060002_RS18085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V060002_RS18090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
V060002_RS18095	COG0049	tRNA binding
V060002_RS18110	COG2923	Belongs to the DsrF TusC family
V060002_RS18115	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
V060002_RS18120	COG2964	Protein conserved in bacteria
V060002_RS18125	COG0545	Peptidyl-prolyl cis-trans isomerase
V060002_RS18135	COG2900	Belongs to the SlyX family
V060002_RS18140	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
V060002_RS18145	COG0330	HflC and HflK could
V060002_RS18150	COG0330	HflC and HflK could
V060002_RS18155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
V060002_RS18160	COG1923	regulation of RNA biosynthetic process
V060002_RS18165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
V060002_RS18170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
V060002_RS18180	COG0802	atpase or kinase
V060002_RS18215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
V060002_RS18220	COG1162	GTPase activity
V060002_RS18225	COG0688	phosphatidylethanolamine metabolic process
V060002_RS18230	COG0471	metal ion transport
V060002_RS18230	COG0490	domain, Protein
V060002_RS18240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
V060002_RS18245	COG4942	peptidase
V060002_RS18260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
V060002_RS18265	COG2816	NAD+ diphosphatase activity
V060002_RS18270	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
V060002_RS18275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
V060002_RS18280	COG0085	RNA polymerase activity
V060002_RS18285	COG0222	ribosome binding
V060002_RS18290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
V060002_RS18300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
V060002_RS18305	COG0250	Participates in transcription elongation, termination and antitermination
V060002_RS18310	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
V060002_RS18315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
V060002_RS18340	COG1072	(Pantothenic acid kinase))
V060002_RS18350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
V060002_RS18360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
V060002_RS18405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
V060002_RS18420	COG3118	belongs to the thioredoxin family
V060002_RS18425	COG0513	Belongs to the DEAD box helicase family
V060002_RS18430	COG0248	Ppx GppA phosphatase
V060002_RS18435	COG0784	Response regulator, receiver
V060002_RS18435	COG2205	protein histidine kinase activity
V060002_RS18440	COG2814	Major facilitator Superfamily
V060002_RS18460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
V060002_RS18465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
V060002_RS18470	COG0511	ligase activity, forming carbon-carbon bonds
V060002_RS18475	COG0439	Biotin carboxylase
V060002_RS18480	COG2264	protein methyltransferase activity
V060002_RS18485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
V060002_RS18490	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
V060002_RS18495	COG1609	Transcriptional regulator
V060002_RS18500	COG0129	dihydroxy-acid dehydratase activity
V060002_RS18505	COG3265	gluconokinase activity
V060002_RS18515	COG0800	Aldolase
V060002_RS18535	COG0840	transmembrane signaling receptor activity
V060002_RS18545	COG2131	deaminase
V060002_RS18570	COG3621	Patatin-like phospholipase
V060002_RS18610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
V060002_RS18615	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
V060002_RS18625	COG0210	DNA helicase
V060002_RS18640	COG1280	lysine exporter protein (LysE YggA)
V060002_RS18655	COG2962	Rard protein
V060002_RS18660	COG0514	ATP-dependent DNA helicase (RecQ)
V060002_RS18675	COG1132	(ABC) transporter
V060002_RS18680	COG4774	siderophore transport
V060002_RS18685	COG1120	ATPase activity
V060002_RS18710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
V060002_RS18715	COG1263	PTS System
V060002_RS18715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
V060002_RS18720	COG2862	Uncharacterized protein family, UPF0114
V060002_RS18725	COG1561	YicC-like family, N-terminal region
V060002_RS18730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
V060002_RS18735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
V060002_RS18740	COG1560	Kdo2-lipid A biosynthetic process
V060002_RS18745	COG1560	Kdo2-lipid A biosynthetic process
V060002_RS18750	COG1309	transcriptional regulator
V060002_RS18760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
V060002_RS18770	COG2003	Belongs to the UPF0758 family
V060002_RS18775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
V060002_RS18780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
V060002_RS18790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
V060002_RS18795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
V060002_RS18800	COG0859	PFAM glycosyl transferase family 9
V060002_RS18805	COG0463	Glycosyl transferase, family 2
V060002_RS18810	COG0859	PFAM glycosyl transferase family 9
V060002_RS18815	COG3642	lipopolysaccharide core region biosynthetic process
V060002_RS18845	COG1519	Transferase
V060002_RS18880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
V060002_RS18885	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
V060002_RS18885	COG0662	Cupin 2, conserved barrel domain protein
V060002_RS18890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
V060002_RS18895	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
V060002_RS18925	COG0318	PFAM AMP-dependent synthetase and ligase
V060002_RS18930	COG1012	belongs to the aldehyde dehydrogenase family
V060002_RS18930	COG1454	alcohol dehydrogenase
V060002_RS18980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
V060002_RS18985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
V060002_RS18990	COG0668	transmembrane transport
V060002_RS18995	COG1573	uracil-dna glycosylase
V060002_RS19005	COG3068	Protein conserved in bacteria
V060002_RS19015	COG1940	carbohydrate kinase activity
V060002_RS19020	COG1253	flavin adenine dinucleotide binding
V060002_RS19025	COG0776	regulation of translation
V060002_RS19035	COG0151	Belongs to the GarS family
V060002_RS19050	COG0789	Transcriptional regulator
V060002_RS19055	COG3710	Transcriptional regulator
V060002_RS19060	COG0531	amino acid
V060002_RS19105	COG3621	Patatin-like phospholipase
V060002_RS19130	COG2131	deaminase
V060002_RS19140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
V060002_RS19145	COG0601	transmembrane transport
V060002_RS19150	COG0747	negative chemotaxis
V060002_RS19205	COG1309	transcriptional regulator
V060002_RS19210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
V060002_RS19215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
V060002_RS19220	COG2960	long-chain fatty acid transporting porin activity
V060002_RS19225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
V060002_RS19230	COG0583	DNA-binding transcription factor activity
V060002_RS19275	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
V060002_RS19280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
V060002_RS19285	COG1739	Uncharacterized protein family UPF0029
V060002_RS19295	COG0183	Belongs to the thiolase family
V060002_RS19300	COG0583	DNA-binding transcription factor activity
V060002_RS19305	COG2814	Major facilitator Superfamily
V060002_RS19310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
V060002_RS19315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
V060002_RS19320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
V060002_RS19325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
V060002_RS19330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
V060002_RS19335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
V060002_RS19340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
V060002_RS19350	COG0356	it plays a direct role in the translocation of protons across the membrane
V060002_RS19355	COG3312	ion transport
V060002_RS19360	COG1475	DNA binding
V060002_RS19365	COG1192	Involved in chromosome partitioning
V060002_RS19375	COG0445	tRNA wobble uridine modification