locus-tag	class	description
HPY12_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HPY12_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HPY12_RS00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HPY12_RS00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY12_RS00030	ENOG4108ZNX	Heat shock protein
HPY12_RS00035	ENOG4105JKW	Valine--pyruvate aminotransferase
HPY12_RS00040	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HPY12_RS00045	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HPY12_RS00060	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HPY12_RS00070	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HPY12_RS00075	ENOG4105C7B	Threonine dehydratase
HPY12_RS00080	ENOG4105C01	Dihydroxy-acid dehydratase
HPY12_RS00085	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HPY12_RS00100	ENOG4105C0P	Mg chelatase subunit ChlI
HPY12_RS00105	ENOG4106HNH	Acyl-transferase
HPY12_RS00110	ENOG4108Z33	Thiol disulfide Interchange Protein
HPY12_RS00115	ENOG4105E27	serine threonine protein kinase
HPY12_RS00125	ENOG4105PC1	Conserved Protein
HPY12_RS00130	ENOG4108N23	SpoOM-related protein
HPY12_RS00135	ENOG4108UT2	hemolysin iii
HPY12_RS00145	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY12_RS00150	ENOG4105C1A	potassium transporter peripheral membrane
HPY12_RS00155	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HPY12_RS00160	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HPY12_RS00165	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPY12_RS00170	ENOG4108WZM	domain protein
HPY12_RS00175	ENOG4105C79	DNA protecting protein DprA
HPY12_RS00180	ENOG4108RPN	Protein smg homolog
HPY12_RS00185	ENOG4108WI1	Dna topoisomerase
HPY12_RS00195	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HPY12_RS00200	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY12_RS00205	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HPY12_RS00210	ENOG4105E2X	shikimate dehydrogenase
HPY12_RS00220	ENOG4108Z0R	Transferase
HPY12_RS00260	ENOG4105WMR	Protein CrcB homolog
HPY12_RS00265	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HPY12_RS00275	ENOG4105D06	uba thif-type nad fad binding protein
HPY12_RS00280	ENOG4105WHD	thiamine biosynthesis protein ThiS
HPY12_RS00285	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HPY12_RS00290	ENOG4105D41	biosynthesis protein thiH
HPY12_RS00295	ENOG4105DC7	peptidase M24
HPY12_RS00295	ENOG4105DC7	peptidase M24
HPY12_RS00300	ENOG4105G2Y	Transcriptional regulator
HPY12_RS00305	ENOG4105CNH	Multidrug resistance protein MdtL
HPY12_RS00315	ENOG4108VVK	transcriptional Regulator, AsnC
HPY12_RS00320	ENOG4105BZU	Histidine kinase
HPY12_RS00335	ENOG4105EMK	carboxylate amino acid amine transporter
HPY12_RS00340	ENOG4108M6U	Universal stress protein A
HPY12_RS00345	ENOG41090A1	ferritin
HPY12_RS00350	ENOG4108V6B	universal stress protein B
HPY12_RS00355	ENOG4105CBX	hi0933 family
HPY12_RS00365	ENOG4105CGY	Dna recombination protein
HPY12_RS00370	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HPY12_RS00375	ENOG4105JC1	sterol-binding domain protein
HPY12_RS00385	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY12_RS00390	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HPY12_RS00395	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HPY12_RS00400	ENOG4105CA0	peroxidase
HPY12_RS00405	ENOG4107R73	Mate efflux family protein
HPY12_RS00415	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HPY12_RS00420	ENOG4105E55	glycerol-3-phosphate acyltransferase
HPY12_RS00425	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HPY12_RS00430	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HPY12_RS00440	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS00450	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HPY12_RS00455	ENOG4105F8V	Hydrolase, tatD family
HPY12_RS00460	ENOG4105D52	delta-aminolevulinic acid dehydratase
HPY12_RS00470	ENOG4105C2M	dna polymerase I
HPY12_RS00480	ENOG4106RE7	Cytochrome
HPY12_RS00490	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
HPY12_RS00495	ENOG4105XCT	Protein of unknown function (DUF2489)
HPY12_RS00500	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY12_RS00505	ENOG410601J	HemY protein
HPY12_RS00510	ENOG4105ECF	c-methyltransferase
HPY12_RS00515	ENOG41076E6	Uroporphyrinogen-III Synthase
HPY12_RS00520	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HPY12_RS00525	ENOG4107T0K	Adenylate cyclase
HPY12_RS00530	ENOG4105XQ6	frataxin-like protein
HPY12_RS00540	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HPY12_RS00545	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HPY12_RS00550	ENOG4105CT0	Protein of unknown function, DUF484
HPY12_RS00555	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY12_RS00560	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
HPY12_RS00565	ENOG4105BZU	Histidine kinase
HPY12_RS00580	ENOG4105DQF	Hydrolase
HPY12_RS00585	ENOG4108EUD	Lysophospholipase
HPY12_RS00590	ENOG410829K	Lysine exporter protein (Lyse ygga)
HPY12_RS00595	ENOG4105D58	Diguanylate phosphodiesterase
HPY12_RS00600	ENOG4108RMU	ferritin dps family protein
HPY12_RS00630	ENOG4106H78	methyltransferase
HPY12_RS00635	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HPY12_RS00640	ENOG4105CAK	Cell division ATP-binding protein ftsE
HPY12_RS00645	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HPY12_RS00650	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY12_RS00655	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
HPY12_RS00670	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
HPY12_RS00675	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HPY12_RS00680	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HPY12_RS00685	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HPY12_RS00755	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HPY12_RS00760	ENOG4105BZU	Histidine kinase
HPY12_RS00765	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS00770	ENOG4105CUX	Signal transduction histidine kinase
HPY12_RS00780	ENOG4105C5F	glutamine synthetase
HPY12_RS00790	ENOG4105CI3	gtp-binding protein typa
HPY12_RS00800	ENOG4107S2Z	UPF0761 membrane protein
HPY12_RS00805	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HPY12_RS00810	ENOG4105SUU	thioesterase domain
HPY12_RS00820	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HPY12_RS00825	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HPY12_RS00830	ENOG4105VEJ	Heat shock protein
HPY12_RS00835	ENOG4108XKW	General secretion pathway protein C
HPY12_RS00845	ENOG4107QHF	type ii secretion system protein e
HPY12_RS00850	ENOG4105D7Q	type ii secretion system
HPY12_RS00855	ENOG4108VAU	general secretion pathway protein G
HPY12_RS00860	ENOG4105VWV	general secretion pathway protein h
HPY12_RS00865	ENOG4105X5Z	General secretion pathway protein I
HPY12_RS00870	ENOG4108WWZ	General secretion pathway protein J
HPY12_RS00875	ENOG4108RTD	type II secretion system protein K
HPY12_RS00880	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
HPY12_RS00885	ENOG4105U1E	general secretion pathway protein M
HPY12_RS00890	ENOG4105PIC	general secretion pathway protein N
HPY12_RS00895	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HPY12_RS00900	ENOG4107RK2	ADP-ribose diphosphatase NudE
HPY12_RS00910	ENOG4105MJ2	Competence protein
HPY12_RS00920	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY12_RS00930	ENOG4105BZM	domain protein
HPY12_RS00935	ENOG4108RRZ	Transcription elongation factor GreB
HPY12_RS00945	ENOG4105E0F	Histidine kinase
HPY12_RS00950	ENOG4105C2W	permease
HPY12_RS00955	ENOG4105CB5	ATP-dependent DNA helicase recG
HPY12_RS00960	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY12_RS00965	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HPY12_RS00970	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HPY12_RS00975	ENOG4105EX9	Membrane
HPY12_RS00980	ENOG4107QN1	sodium solute
HPY12_RS01000	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HPY12_RS01010	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY12_RS01015	ENOG4108IJ0	Aspartate ammonia-lyase
HPY12_RS01020	ENOG4105BZU	Histidine kinase
HPY12_RS01025	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
HPY12_RS01030	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HPY12_RS01040	ENOG4105E0F	Histidine kinase
HPY12_RS01045	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HPY12_RS01055	ENOG41076HS	cation diffusion facilitator family transporter
HPY12_RS01060	ENOG4105CTQ	phosphohexokinase
HPY12_RS01065	ENOG4105CBT	Fructose-1,6-bisphosphatase
HPY12_RS01070	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
HPY12_RS01075	ENOG4105SYT	Methylenetetrahydrofolate reductase
HPY12_RS01080	ENOG4105CFH	Aspartokinase
HPY12_RS01085	ENOG4105C28	cystathionine
HPY12_RS01090	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
HPY12_RS01095	ENOG4105C6K	Malic enzyme
HPY12_RS01100	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HPY12_RS01105	ENOG4105C25	Primosomal protein n'
HPY12_RS01110	ENOG4105ETE	Transcriptional regulator (LacI family
HPY12_RS01115	ENOG41063M6	Cell Division Protein
HPY12_RS01120	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HPY12_RS01125	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HPY12_RS01130	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HPY12_RS01135	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY12_RS01145	ENOG4105CP7	Triose-phosphate isomerase
HPY12_RS01170	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY12_RS01175	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY12_RS01185	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HPY12_RS01190	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY12_RS01200	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
HPY12_RS01205	ENOG4105E33	succinate dehydrogenase
HPY12_RS01215	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
HPY12_RS01220	ENOG4107YZP	Rhodanese domain protein
HPY12_RS01225	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HPY12_RS01230	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HPY12_RS01235	ENOG4105D7W	serine acetyltransferase
HPY12_RS01245	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HPY12_RS01250	ENOG4105CWC	Acetylornithine deacetylase
HPY12_RS01255	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HPY12_RS01260	ENOG4105CAS	nag kinase
HPY12_RS01265	ENOG4105CDH	Citrulline--aspartate ligase
HPY12_RS01270	ENOG4105CH7	arginosuccinase
HPY12_RS01280	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY12_RS01285	ENOG4105EHV	domain protein
HPY12_RS01295	ENOG4108JQC	penicillin-binding protein 1A
HPY12_RS01320	ENOG4105E4G	Type IV pilus
HPY12_RS01325	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HPY12_RS01330	ENOG4105D49	3-dehydroquinate synthase
HPY12_RS01340	ENOG4105DFE	Dna adenine methylase
HPY12_RS01345	ENOG4105DJV	ribulose-phosphate 3-epimerase
HPY12_RS01350	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY12_RS01355	ENOG4105C31	Tryptophanyl-tRNA synthetase
HPY12_RS01370	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HPY12_RS01375	ENOG4105DDQ	anthranilate synthase
HPY12_RS01380	ENOG4105C8Y	Acetylornithine aminotransferase
HPY12_RS01400	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HPY12_RS01405	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
HPY12_RS01415	ENOG4105DNZ	Alpha Beta Hydrolase
HPY12_RS01425	ENOG4105C5H	ABC transporter
HPY12_RS01430	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HPY12_RS01445	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HPY12_RS01450	ENOG4108RS6	transposase
HPY12_RS01455	ENOG4105D44	asparaginase
HPY12_RS01460	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HPY12_RS01470	ENOG4105E68	Sulfatase
HPY12_RS01475	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HPY12_RS01480	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HPY12_RS01485	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HPY12_RS01490	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HPY12_RS01495	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HPY12_RS01500	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HPY12_RS01505	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY12_RS01510	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HPY12_RS01515	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HPY12_RS01520	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HPY12_RS01525	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HPY12_RS01530	ENOG41083MP	50s ribosomal protein l29
HPY12_RS01535	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HPY12_RS01540	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HPY12_RS01545	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HPY12_RS01550	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY12_RS01555	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HPY12_RS01560	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HPY12_RS01570	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HPY12_RS01575	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HPY12_RS01580	ENOG4105VPB	50S ribosomal protein L30
HPY12_RS01590	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HPY12_RS01600	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY12_RS01605	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HPY12_RS01610	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HPY12_RS01615	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY12_RS01620	ENOG4108ZT0	50S ribosomal protein l17
HPY12_RS01630	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY12_RS01635	ENOG4108UBT	opacity-associated protein
HPY12_RS01640	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY12_RS01645	ENOG4107YB6	acetyltransferase, (GNAT) family
HPY12_RS01650	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS01660	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HPY12_RS01665	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HPY12_RS01670	ENOG4105C11	sulfate adenylyltransferase), subunit 2
HPY12_RS01675	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HPY12_RS01680	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HPY12_RS01700	ENOG4105C19	ABC transporter
HPY12_RS01715	ENOG4108UUE	Transcriptional regulator
HPY12_RS01720	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HPY12_RS01725	ENOG4105CFU	surface antigen
HPY12_RS01735	ENOG41066HZ	AIG2-like family
HPY12_RS01740	ENOG4105F0N	pyrophosphate phospho-hydrolase
HPY12_RS01750	ENOG4105DFU	Cell wall formation (By similarity)
HPY12_RS01755	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HPY12_RS01765	ENOG4106SMU	thiamine transporter membrane protein
HPY12_RS01770	ENOG4107T0D	ABC, transporter
HPY12_RS01775	ENOG4105N42	UPF0307 protein
HPY12_RS01780	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HPY12_RS01785	ENOG4105CJW	magnesium transporter
HPY12_RS01790	ENOG41080Z8	PHOSPHOCARRIER protein
HPY12_RS01795	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HPY12_RS01800	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HPY12_RS01805	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HPY12_RS01810	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY12_RS01815	ENOG4108IUZ	ABC transporter
HPY12_RS01820	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
HPY12_RS01830	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HPY12_RS01835	ENOG4105C2X	Arabinose 5-phosphate isomerase
HPY12_RS01845	ENOG4105DHJ	ABC, transporter
HPY12_RS01850	ENOG4105CY3	ABC transporter, permease
HPY12_RS01855	ENOG4107PE3	Mammalian cell entry related domain protein
HPY12_RS01860	ENOG4105E3I	toluene tolerance
HPY12_RS01870	ENOG4105VFK	BolA family
HPY12_RS01875	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HPY12_RS01880	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HPY12_RS01885	ENOG4105KME	endoribonuclease L-psp
HPY12_RS01895	ENOG4105CXT	aspartate transcarbamylase
HPY12_RS01905	ENOG4108IAB	Phoh family
HPY12_RS01915	ENOG4105D3G	Pseudouridine synthase
HPY12_RS01920	ENOG4105C5I	Dehydrogenase
HPY12_RS01925	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HPY12_RS01930	ENOG4105MYG	DNA polymerase iii, chi subunit
HPY12_RS01935	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY12_RS01940	ENOG4108M8S	permease YjgP YjgQ family protein
HPY12_RS01945	ENOG4108K5H	permease YjgP YjgQ family protein
HPY12_RS01960	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY12_RS02005	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY12_RS02010	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HPY12_RS02015	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HPY12_RS02050	ENOG4105C7K	acetolactate synthase
HPY12_RS02055	ENOG4108ZP8	Acetolactate synthase small subunit
HPY12_RS02060	ENOG4108JQ1	Dehydrogenase
HPY12_RS02065	ENOG4105E66	phosphoriboisomerase A
HPY12_RS02070	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HPY12_RS02080	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
HPY12_RS02090	ENOG4105D0A	hydroxylase
HPY12_RS02095	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY12_RS02110	ENOG4105Y75	tpr repeat protein
HPY12_RS02120	ENOG4108IYU	L-aspartate oxidase
HPY12_RS02125	ENOG4105EMN	RNA polymerase sigma factor
HPY12_RS02140	ENOG4105WMJ	Positive regulator of sigma E, RseC MucC
HPY12_RS02145	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HPY12_RS02150	ENOG4105C3F	Signal peptidase i
HPY12_RS02155	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HPY12_RS02160	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HPY12_RS02165	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HPY12_RS02170	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HPY12_RS02195	ENOG4105BZU	Histidine kinase
HPY12_RS02205	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HPY12_RS02210	ENOG4105DXN	mazG family
HPY12_RS02215	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HPY12_RS02220	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HPY12_RS02240	ENOG4106MWK	domain protein
HPY12_RS02245	ENOG4105CJ3	phosphate transporter
HPY12_RS02250	ENOG4107IX6	phosphate transport regulator
HPY12_RS02255	ENOG4105I7R	Adenylate cyclase
HPY12_RS02265	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS02270	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HPY12_RS02275	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HPY12_RS02280	ENOG4105DFG	type I secretion outer membrane protein
HPY12_RS02285	ENOG41087AY	ADP-Ribose pyrophosphatase
HPY12_RS02290	ENOG4108SX3	cytoplasmic protein
HPY12_RS02295	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HPY12_RS02300	ENOG4105IPS	esterase
HPY12_RS02305	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY12_RS02310	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY12_RS02320	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HPY12_RS02325	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HPY12_RS02330	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HPY12_RS02335	ENOG4105D7Q	type ii secretion system
HPY12_RS02340	ENOG4107QHF	type ii secretion system protein e
HPY12_RS02345	ENOG4105X0D	Fimbrial protein
HPY12_RS02350	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HPY12_RS02360	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY12_RS02365	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HPY12_RS02370	ENOG4105T95	Thiol disulfide interChange protein
HPY12_RS02375	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HPY12_RS02380	ENOG4105CGH	5'-nucleotidase
HPY12_RS02385	ENOG41073TP	transcriptional regulator
HPY12_RS02390	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HPY12_RS02395	ENOG4107QSN	dihydrolipoamide acetyltransferase
HPY12_RS02400	ENOG4107QN2	dihydrolipoyl dehydrogenase
HPY12_RS02415	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HPY12_RS02420	ENOG4105CJN	penicillin-binding protein
HPY12_RS02425	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HPY12_RS02430	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HPY12_RS02440	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HPY12_RS02455	ENOG4105DFU	Cell wall formation (By similarity)
HPY12_RS02460	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HPY12_RS02465	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HPY12_RS02470	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HPY12_RS02475	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY12_RS02485	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY12_RS02490	ENOG4105M6F	mutator MutT protein
HPY12_RS02495	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HPY12_RS02505	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HPY12_RS02510	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HPY12_RS02525	ENOG4105EJ9	Membrane
HPY12_RS02530	ENOG4105VP0	transcriptional regulator, lysR family
HPY12_RS02535	ENOG4105EN6	Membrane
HPY12_RS02540	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HPY12_RS02550	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HPY12_RS02560	ENOG4105BZ8	glutamate synthase
HPY12_RS02565	ENOG4105CBC	glutamate synthase
HPY12_RS02580	ENOG4105N5T	Radical SAM Protein
HPY12_RS02590	ENOG4105BZU	Histidine kinase
HPY12_RS02595	ENOG41065U4	response regulator
HPY12_RS02610	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HPY12_RS02630	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HPY12_RS02635	ENOG4105D98	threonine synthase
HPY12_RS02640	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
HPY12_RS02645	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HPY12_RS02650	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HPY12_RS02665	ENOG4105BZG	amino acid carrier protein
HPY12_RS02680	ENOG4105EYA	deoxyribonuclease
HPY12_RS02685	ENOG4105D9N	nucleoside
HPY12_RS02695	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HPY12_RS02700	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HPY12_RS02705	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HPY12_RS02710	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY12_RS02720	ENOG4105EAC	phosphoserine phosphatase
HPY12_RS02730	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HPY12_RS02735	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY12_RS02740	ENOG4108IQE	Amp-dependent synthetase and ligase
HPY12_RS02745	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY12_RS02755	ENOG4105CNT	hydrolase family 2
HPY12_RS02760	ENOG41060NJ	transcriptional regulator
HPY12_RS02765	ENOG4108Y51	tRNA-binding protein
HPY12_RS02780	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY12_RS02785	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HPY12_RS02795	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
HPY12_RS02800	ENOG4105X2V	dna damage-inducible protein
HPY12_RS02815	ENOG4105DSY	exodeoxyribonuclease V, gamma
HPY12_RS02820	ENOG4107QKA	exodeoxyribonuclease V beta
HPY12_RS02825	ENOG4107QYX	exodeoxyribonuclease v alpha
HPY12_RS02835	ENOG4107QZM	n-acetylglutamate synthase
HPY12_RS02845	ENOG4105CA3	membrane-bound lytic murein transglycosylase
HPY12_RS02850	ENOG4105CUZ	uba thif-type nad fad binding protein
HPY12_RS02855	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HPY12_RS02860	ENOG4105C9B	Cysteine desulfurase
HPY12_RS02865	ENOG4107S0N	DJ-1 family
HPY12_RS02870	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HPY12_RS02875	ENOG4105DRB	nucleoside-specific channel-forming protein
HPY12_RS02885	ENOG4105K6V	RNA polymerase
HPY12_RS02900	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY12_RS02910	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY12_RS02915	ENOG4105M85	Bola protein
HPY12_RS02920	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY12_RS02925	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY12_RS02930	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY12_RS02935	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY12_RS02940	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HPY12_RS02945	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
HPY12_RS02950	ENOG4105CJ2	(LipO)protein
HPY12_RS02970	ENOG4105BZU	Histidine kinase
HPY12_RS02975	ENOG4105C8J	)-transporter
HPY12_RS02985	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY12_RS02990	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY12_RS02995	ENOG4105CIN	aminoacyl-histidine dipeptidase
HPY12_RS03000	ENOG4105C7N	Xanthine uracil vitamin C permease
HPY12_RS03005	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HPY12_RS03010	ENOG4108DJV	Fermentation respiration switch protein
HPY12_RS03015	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
HPY12_RS03020	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HPY12_RS03025	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HPY12_RS03030	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HPY12_RS03035	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HPY12_RS03050	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HPY12_RS03055	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HPY12_RS03060	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HPY12_RS03065	ENOG4108ZAI	phosphatidylglycerophosphatase a
HPY12_RS03070	ENOG4108T8E	UPF0325 protein
HPY12_RS03075	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HPY12_RS03080	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HPY12_RS03085	ENOG4105CE9	30S ribosomal protein S2
HPY12_RS03090	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HPY12_RS03095	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HPY12_RS03100	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HPY12_RS03105	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HPY12_RS03110	ENOG4105KNE	Phosphatidate cytidylyltransferase
HPY12_RS03115	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HPY12_RS03120	ENOG4105DZP	Membrane-associated zinc metalloprotease
HPY12_RS03130	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
HPY12_RS03135	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY12_RS03140	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HPY12_RS03145	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY12_RS03150	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HPY12_RS03155	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY12_RS03160	ENOG4105C0B	DNA polymerase III (alpha subunit)
HPY12_RS03165	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HPY12_RS03170	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HPY12_RS03175	ENOG4105N7H	Cytochrome
HPY12_RS03180	ENOG4105PY6	Phenolic acid decarboxylase
HPY12_RS03185	ENOG4108YZA	Nitrogen regulatory protein pii
HPY12_RS03190	ENOG4107NA1	Endonuclease Exonuclease phosphatase
HPY12_RS03195	ENOG4105E9H	Lytic Murein transglycosylase
HPY12_RS03200	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HPY12_RS03205	ENOG4105D1A	Methyltransferase
HPY12_RS03210	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HPY12_RS03215	ENOG4107RZZ	dna polymerase iii epsilon subunit
HPY12_RS03225	ENOG4107QPN	acyl-Coa dehydrogenase
HPY12_RS03230	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY12_RS03235	ENOG4105E7A	Glutamine amidotransferase
HPY12_RS03240	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HPY12_RS03245	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HPY12_RS03250	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HPY12_RS03255	ENOG4105BZU	Histidine kinase
HPY12_RS03260	ENOG4105FE9	pseudouridine synthase
HPY12_RS03265	ENOG4108DG9	Smr protein MutS2
HPY12_RS03285	ENOG4105E2D	ec 3.2.1.52
HPY12_RS03295	ENOG4105C59	p-type ATPase
HPY12_RS03300	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HPY12_RS03305	ENOG4105UYK	outer membrane protein a
HPY12_RS03315	ENOG4107RBR	Receptor
HPY12_RS03320	ENOG4105Q26	Siderophore-interacting protein
HPY12_RS03325	ENOG4105C0W	non-ribosomal peptide synthetase
HPY12_RS03360	ENOG4107R88	Chemotaxis protein (CheV)
HPY12_RS03365	ENOG4105BZU	Histidine kinase
HPY12_RS03370	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HPY12_RS03375	ENOG4108ZC9	flagellar basal-body rod protein flgc
HPY12_RS03380	ENOG4105W00	Flagellar hook capping protein
HPY12_RS03385	ENOG4105BZE	flagellar hook protein, FlgE
HPY12_RS03390	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HPY12_RS03395	ENOG4105CGA	flagellar basal-body rod protein FlgG
HPY12_RS03400	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY12_RS03405	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
HPY12_RS03410	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HPY12_RS03425	ENOG4105I03	Flagellin
HPY12_RS03430	ENOG4105I03	Flagellin
HPY12_RS03515	ENOG4105C3G	gtp-binding protein
HPY12_RS03520	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HPY12_RS03525	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HPY12_RS03530	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HPY12_RS03535	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
HPY12_RS03540	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HPY12_RS03545	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HPY12_RS03550	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HPY12_RS03555	ENOG4108YY7	Invasion gene expression up-regulator SirB
HPY12_RS03560	ENOG41063JG	Transcriptional regulator
HPY12_RS03565	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HPY12_RS03570	ENOG4105CGH	5'-nucleotidase
HPY12_RS03575	ENOG4108Z66	YbaK ebsC protein
HPY12_RS03580	ENOG4105C2W	permease
HPY12_RS03595	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HPY12_RS03600	ENOG4105K89	arsenate reductase
HPY12_RS03605	ENOG4105ERG	peptidase m48, ste24p
HPY12_RS03620	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS03625	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY12_RS03640	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY12_RS03660	ENOG4105KUZ	arsenate reductase
HPY12_RS03675	ENOG4105QZU	Inner membrane protein YfeZ
HPY12_RS03680	ENOG4105EZR	dyp-type peroxidase family protein
HPY12_RS03685	ENOG4105I03	Flagellin
HPY12_RS03690	ENOG4105I03	Flagellin
HPY12_RS03695	ENOG4105I03	Flagellin
HPY12_RS03700	ENOG41063QE	flagellar protein FlaG
HPY12_RS03705	ENOG4107W9T	flagellar hook-associated
HPY12_RS03715	ENOG4105MQ3	flagellar protein FliS
HPY12_RS03725	ENOG4105BZU	Histidine kinase
HPY12_RS03735	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
HPY12_RS03740	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HPY12_RS03745	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY12_RS03750	ENOG4105W2B	Flagellar assembly protein
HPY12_RS03755	ENOG4108JIR	Flagellum-specific ATP synthase
HPY12_RS03775	ENOG4105X6C	Flagellar basal body-associated protein FliL
HPY12_RS03780	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HPY12_RS03785	ENOG4105DD5	Flagellar motor switch protein
HPY12_RS03790	ENOG4105VTB	flagellar biosynthesis protein fliO
HPY12_RS03795	ENOG4105CN7	Flagellar biosynthetic protein FliP
HPY12_RS03800	ENOG4105VS8	Flagellar biosynthetic protein fliq
HPY12_RS03805	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HPY12_RS03810	ENOG4105D00	flagellar biosynthetic protein flhB
HPY12_RS03815	ENOG4108DG9	Smr protein MutS2
HPY12_RS03820	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HPY12_RS03825	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HPY12_RS03830	ENOG4105EN6	Membrane
HPY12_RS03835	ENOG4108BPE	-transporting atpase
HPY12_RS03840	ENOG4105MH2	YfcL protein
HPY12_RS03845	ENOG4105Q8W	reductase
HPY12_RS03850	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HPY12_RS03855	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY12_RS03860	ENOG4108RS6	transposase
HPY12_RS03865	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
HPY12_RS03870	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY12_RS03875	ENOG41090R7	Ferric uptake
HPY12_RS03885	ENOG4105CMU	LysR family (Transcriptional regulator
HPY12_RS03890	ENOG4105VAW	lrga family
HPY12_RS03895	ENOG41067MG	lrgb family
HPY12_RS03900	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
HPY12_RS03910	ENOG4105EV9	Alpha Beta Hydrolase
HPY12_RS03915	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
HPY12_RS03920	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
HPY12_RS03930	ENOG4107QNR	UPF0135 protein
HPY12_RS03935	ENOG4105BZN	citrate synthase
HPY12_RS03940	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
HPY12_RS03945	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HPY12_RS03955	ENOG4105E33	succinate dehydrogenase
HPY12_RS03960	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HPY12_RS03965	ENOG4105C7S	Dehydrogenase
HPY12_RS03970	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HPY12_RS03975	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HPY12_RS03980	ENOG4105FAV	ABC, transporter
HPY12_RS03985	ENOG4105FDK	ABC transporter
HPY12_RS03990	ENOG4105NXV	High-affinity zinc uptake system protein
HPY12_RS03995	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HPY12_RS04000	ENOG4105XFK	Ferrous iron transport protein A
HPY12_RS04020	ENOG4105C75	arginyL-tRNA synthetase
HPY12_RS04030	ENOG4108JQM	Insulinase (Peptidase family M16)
HPY12_RS04035	ENOG4108BY2	phosphohistidine phosphatase
HPY12_RS04040	ENOG4105D7B	Flagellar biosynthesis protein flha
HPY12_RS04045	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HPY12_RS04055	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY12_RS04060	ENOG4108VYJ	response regulator receiver protein
HPY12_RS04065	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HPY12_RS04075	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY12_RS04080	ENOG4107QJE	Chromosome Partitioning Protein
HPY12_RS04090	ENOG4108V3W	Chemotaxis protein, CheW
HPY12_RS04100	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS04105	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
HPY12_RS04110	ENOG41060IM	Heme exporter protein
HPY12_RS04115	ENOG41067VX	Heme exporter protein
HPY12_RS04120	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HPY12_RS04125	ENOG4105DA4	cytochrome c-type biogenesis protein
HPY12_RS04130	ENOG4107QX9	Thiol disulfide interChange protein
HPY12_RS04135	ENOG4105KWW	Biogenesis protein
HPY12_RS04145	ENOG410903C	(LipO)protein
HPY12_RS04160	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HPY12_RS04165	ENOG4105M2J	Glutaredoxin
HPY12_RS04170	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY12_RS04175	ENOG4105DGU	Histone deacetylase
HPY12_RS04190	ENOG4105E68	Sulfatase
HPY12_RS04195	ENOG4105YDX	UPF0352 protein
HPY12_RS04200	ENOG4106V8H	Nucleoid-associated protein
HPY12_RS04210	ENOG4105DFD	Na H antiporter
HPY12_RS04215	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HPY12_RS04220	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HPY12_RS04225	ENOG4105C0A	alcohol dehydrogenase
HPY12_RS04235	ENOG4105CHH	sulfate transporter
HPY12_RS04240	ENOG4105C03	ribonuclease
HPY12_RS04245	ENOG4105EI2	Pseudouridine synthase
HPY12_RS04250	ENOG4108UHJ	MAF-like protein
HPY12_RS04255	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HPY12_RS04260	ENOG4105VGS	50s ribosomal protein l32
HPY12_RS04265	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HPY12_RS04270	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY12_RS04275	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HPY12_RS04280	ENOG4105CHR	reductase
HPY12_RS04285	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HPY12_RS04290	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HPY12_RS04295	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
HPY12_RS04300	ENOG4105HHA	aminodeoxychorismate lyase
HPY12_RS04305	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HPY12_RS04310	ENOG4107QRG	dna polymerase iii
HPY12_RS04315	ENOG4105F8V	Hydrolase, tatD family
HPY12_RS04320	ENOG4105CI1	PTS System
HPY12_RS04330	ENOG4105C8J	)-transporter
HPY12_RS04345	ENOG4108NRW	Phospholipase, patatin family
HPY12_RS04350	ENOG4105CA9	Pyruvate kinase
HPY12_RS04355	ENOG4105DAG	ROK family
HPY12_RS04375	ENOG4105DHI	Methyltransferase
HPY12_RS04385	ENOG4105DSB	aldose 1-epimerase
HPY12_RS04390	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY12_RS04395	ENOG4105E0X	reductase
HPY12_RS04405	ENOG4105VUT	cytoplasmic protein
HPY12_RS04410	ENOG4105HDK	L-asparaginase
HPY12_RS04415	ENOG4105D07	Signal peptide peptidase, SppA
HPY12_RS04420	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY12_RS04425	ENOG4105CIY	formyltetrahydrofolate deformylase
HPY12_RS04435	ENOG4105DVT	helicase
HPY12_RS04440	ENOG41072GX	Peptidase M22 Glycoprotease
HPY12_RS04455	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HPY12_RS04460	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY12_RS04465	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HPY12_RS04485	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HPY12_RS04490	ENOG4105DK2	UPF0207 protein
HPY12_RS04495	ENOG4105CHM	Aminotransferase
HPY12_RS04500	ENOG4105E4F	Isochorismate synthase
HPY12_RS04505	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HPY12_RS04510	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HPY12_RS04515	ENOG4108IPT	Naphthoate synthase
HPY12_RS04525	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY12_RS04530	ENOG4105DKK	Benzoate
HPY12_RS04535	ENOG4108JCI	Transcriptional regulator
HPY12_RS04540	ENOG4108N3W	hemolysin secretion protein
HPY12_RS04550	ENOG4107S74	Lysophospholipid transporter LplT
HPY12_RS04575	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HPY12_RS04580	ENOG4107QMS	site-determining protein
HPY12_RS04585	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HPY12_RS04590	ENOG4105VNG	YcgL domain-containing protein
HPY12_RS04595	ENOG4105CVE	Lytic murein transglycosylase
HPY12_RS04600	ENOG4105JQN	Transcriptional regulator
HPY12_RS04605	ENOG4105D9N	nucleoside
HPY12_RS04610	ENOG410662T	chitinase
HPY12_RS04615	ENOG4105CUW	cytochrome C-TYPE protein
HPY12_RS04620	ENOG4107QY8	reductase
HPY12_RS04630	ENOG4105JQN	Transcriptional regulator
HPY12_RS04645	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HPY12_RS04680	ENOG4108HPI	phosphatidate Cytidylyltransferase
HPY12_RS04690	ENOG4105BZU	Histidine kinase
HPY12_RS04700	ENOG4105CNG	UPF0061 protein
HPY12_RS04705	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HPY12_RS04710	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HPY12_RS04715	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY12_RS04720	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS04735	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HPY12_RS04740	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HPY12_RS04745	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HPY12_RS04750	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HPY12_RS04755	ENOG4105K70	DNA-binding protein
HPY12_RS04760	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HPY12_RS04765	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
HPY12_RS04770	ENOG4105CAT	Cytidine monophosphate kinase
HPY12_RS04775	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HPY12_RS04780	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY12_RS04785	ENOG4105Q4A	inner membrane protein yciS
HPY12_RS04790	ENOG4105CFV	Tetratricopeptide repeat protein
HPY12_RS04800	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
HPY12_RS04810	ENOG4107R11	Transcriptional regulator
HPY12_RS04820	ENOG4105DCF	alanine dehydrogenase
HPY12_RS04825	ENOG4105EW9	transcriptional regulator AsnC family
HPY12_RS04830	ENOG4105CNU	cell division protein FtsK
HPY12_RS04835	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HPY12_RS04840	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY12_RS04845	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
HPY12_RS04855	ENOG4108NVR	Methyl-accepting chemotaxis
HPY12_RS04860	ENOG4105K59	histidine triad (HIT) protein
HPY12_RS04885	ENOG4105D0Y	UPF0227 protein
HPY12_RS04890	ENOG4105CEP	NADH dehydrogenase
HPY12_RS04900	ENOG4106M3D	hemolysin
HPY12_RS04910	ENOG4108JA2	transcriptioN-repair coupling factor
HPY12_RS04925	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY12_RS04930	ENOG4105D60	lipoprotein releasing system transmembrane protein
HPY12_RS04940	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HPY12_RS04945	ENOG4105BZ1	(ABC) transporter
HPY12_RS04950	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HPY12_RS04955	ENOG4105W49	UPF0434 protein
HPY12_RS04960	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HPY12_RS04965	ENOG4105ED1	spovr family
HPY12_RS04970	ENOG4106AKX	UPF0229 protein
HPY12_RS04975	ENOG4105CYN	Serine protein kinase
HPY12_RS04980	ENOG4105XWI	UPF0304 protein
HPY12_RS04990	ENOG4105F1A	Pyruvate formate-lyase
HPY12_RS04995	ENOG4108N3W	hemolysin secretion protein
HPY12_RS05005	ENOG4105C6N	Formate acetyltransferase
HPY12_RS05015	ENOG4108JEH	abc transporter atp-binding protein
HPY12_RS05020	ENOG4105E89	ABC transporter
HPY12_RS05025	ENOG4105DSP	amino acid AbC transporter
HPY12_RS05030	ENOG4106YG3	ABC transporter
HPY12_RS05035	ENOG4105CGK	Exodeoxyribonuclease III
HPY12_RS05040	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS05045	ENOG4106428	Protein of unknown function (DUF2496)
HPY12_RS05055	ENOG4105EJ9	Membrane
HPY12_RS05060	ENOG4105DVT	helicase
HPY12_RS05065	ENOG4105ZU8	porin-like protein H
HPY12_RS05075	ENOG4105K5B	UPF0225 protein
HPY12_RS05080	ENOG4105D58	Diguanylate phosphodiesterase
HPY12_RS05085	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HPY12_RS05090	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HPY12_RS05095	ENOG4105C8N	cysteinyl-tRNA synthetase
HPY12_RS05100	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HPY12_RS05105	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HPY12_RS05115	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY12_RS05120	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY12_RS05130	ENOG4105KJB	cyd operon protein YbgE
HPY12_RS05135	ENOG4107YD3	Thioesterase
HPY12_RS05140	ENOG4105E02	MotA TolQ exbB proton channel
HPY12_RS05145	ENOG4105M8F	Biopolymer transport protein exbD tolR
HPY12_RS05155	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HPY12_RS05160	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HPY12_RS05170	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HPY12_RS05180	ENOG4105BZU	Histidine kinase
HPY12_RS05185	ENOG4108RNS	Exports L-alanine (By similarity)
HPY12_RS05190	ENOG4105EIP	mannose-6-phosphate isomerase
HPY12_RS05195	ENOG4105DM4	PTS System
HPY12_RS05200	ENOG4106R3P	AraC family transcriptional regulator
HPY12_RS05210	ENOG4108YRF	PTS System
HPY12_RS05215	ENOG4105DM4	PTS System
HPY12_RS05220	ENOG4105DM4	PTS System
HPY12_RS05230	ENOG4105C26	Dehydrogenase
HPY12_RS05235	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HPY12_RS05240	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY12_RS05250	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY12_RS05330	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPY12_RS05380	ENOG4105MRD	Phage derived protein Gp49-like (DUF891)
HPY12_RS05435	ENOG4105T95	Thiol disulfide interChange protein
HPY12_RS05495	ENOG4105F88	accessory colonization factor AcfD
HPY12_RS05525	ENOG4105VT2	5-hydroxyisourate hydrolase
HPY12_RS05540	ENOG4107VGF	ig domain protein group 2 domain protein
HPY12_RS05550	ENOG4105XB6	Toxin coregulated pilin
HPY12_RS05565	ENOG4105GRU	toxin co-regulated pilus biosynthesis outer membrane protein C
HPY12_RS05585	ENOG4107QHF	type ii secretion system protein e
HPY12_RS05590	ENOG4108VEY	type ii secretion system
HPY12_RS05635	ENOG4108MA4	Peptidase M66
HPY12_RS05660	ENOG4108M3R	transcriptional activator CadC
HPY12_RS05665	ENOG4105BZS	acriflavin resistance protein
HPY12_RS05715	ENOG4108RS6	transposase
HPY12_RS05740	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
HPY12_RS05805	ENOG410679B	prophage CP4-57 regulatory protein alpA
HPY12_RS05810	ENOG4105DFP	Integrase
HPY12_RS05835	ENOG4105DY2	Paraquat-inducible protein b
HPY12_RS05840	ENOG4105F1S	paraquat-inducible protein a
HPY12_RS05845	ENOG4108R86	Transcriptional regulator
HPY12_RS05850	ENOG4105C26	Dehydrogenase
HPY12_RS05855	ENOG4105MTM	Protein of unknown function (DUF1496)
HPY12_RS05865	ENOG41067SE	Tetr family transcriptional regulator
HPY12_RS05870	ENOG4107QPN	acyl-Coa dehydrogenase
HPY12_RS05880	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HPY12_RS05885	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HPY12_RS05890	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HPY12_RS05900	ENOG4105RKX	Protein of unknown function (DUF2498)
HPY12_RS05905	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HPY12_RS05910	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY12_RS05915	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HPY12_RS05935	ENOG4105HP8	regulator of competence-specific genes
HPY12_RS05940	ENOG4105ETE	Transcriptional regulator (LacI family
HPY12_RS05945	ENOG4108SBI	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY12_RS05950	ENOG4106WF9	DNA-binding transcriptional regulator TorR
HPY12_RS05955	ENOG4107S90	membrAne
HPY12_RS05960	ENOG4106371	Methyltransferase
HPY12_RS05965	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
HPY12_RS05970	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
HPY12_RS05980	ENOG4107QW4	alcohol dehydrogenase
HPY12_RS05985	ENOG4105CF7	AraC family transcriptional regulator
HPY12_RS05995	ENOG4105EW9	transcriptional regulator AsnC family
HPY12_RS06005	ENOG4105CCT	upf0313 protein
HPY12_RS06030	ENOG4105DZ2	Transcriptional regulator
HPY12_RS06035	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HPY12_RS06045	ENOG4105K9H	YciI-like protein
HPY12_RS06050	ENOG4105NAU	thioesterase Superfamily protein
HPY12_RS06055	ENOG4107835	probably involved in intracellular septation (By similarity)
HPY12_RS06065	ENOG4105GFG	DUF218 domain
HPY12_RS06070	ENOG4107SRH	Nad-dependent epimerase dehydratase
HPY12_RS06080	ENOG4105TMB	Formate nitrite transporter
HPY12_RS06095	ENOG4107QY8	reductase
HPY12_RS06115	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HPY12_RS06130	ENOG4108JQ2	peptide transport system atp-binding protein
HPY12_RS06135	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
HPY12_RS06140	ENOG4108EU3	peptide transport system, permease
HPY12_RS06145	ENOG4108I5W	peptide transport system, permease protein
HPY12_RS06150	ENOG4108J59	Extracellular solute-binding protein, family 5
HPY12_RS06155	ENOG4105E51	psp operon transcriptional activator
HPY12_RS06160	ENOG41087YS	Phage shock protein A
HPY12_RS06175	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HPY12_RS06190	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HPY12_RS06195	ENOG4105C28	cystathionine
HPY12_RS06205	ENOG4105C8J	)-transporter
HPY12_RS06210	ENOG4108W1A	pseudouridine synthase
HPY12_RS06215	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
HPY12_RS06220	ENOG4108VGW	abc transporter atp-binding protein
HPY12_RS06225	ENOG4105CXZ	ABC transporter, permease
HPY12_RS06230	ENOG4105VNH	ABC transporter solute-binding protein
HPY12_RS06240	ENOG4105XZD	Fe-S protein
HPY12_RS06250	ENOG4107QWP	ABC-2 type transporter
HPY12_RS06255	ENOG4105CJ1	ABC, transporter
HPY12_RS06265	ENOG4105C44	Serine transporter
HPY12_RS06275	ENOG4105CJW	magnesium transporter
HPY12_RS06285	ENOG4105BZU	Histidine kinase
HPY12_RS06295	ENOG4105KXC	Collagenase
HPY12_RS06325	ENOG4108N3W	hemolysin secretion protein
HPY12_RS06340	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HPY12_RS06345	ENOG4105BZU	Histidine kinase
HPY12_RS06360	ENOG4105CFI	type iii restriction protein res subunit
HPY12_RS06365	ENOG4105I08	Pseudouridine synthase
HPY12_RS06370	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY12_RS06380	ENOG4105CGD	Nad-dependent epimerase dehydratase
HPY12_RS06385	ENOG4105UQX	Mate efflux family protein
HPY12_RS06390	ENOG4108I0Y	(ABC) transporter
HPY12_RS06405	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HPY12_RS06415	ENOG4105E3Q	saccharopine dehydrogenase
HPY12_RS06420	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
HPY12_RS06425	ENOG4105CDV	Ompa motb domain protein
HPY12_RS06430	ENOG4105DFG	type I secretion outer membrane protein
HPY12_RS06450	ENOG4105F04	LysR family Transcriptional regulator
HPY12_RS06460	ENOG4108VKG	metal-dependent hydrolase
HPY12_RS06465	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HPY12_RS06475	ENOG41090FY	type IV pilus biogenesis stability protein PilW
HPY12_RS06480	ENOG4105CVG	Homoserine O-transsuccinylase
HPY12_RS06500	ENOG4107V40	secretion protein, HlyD family
HPY12_RS06515	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY12_RS06520	ENOG4106YYS	transcriptional regulatory protein
HPY12_RS06530	ENOG4107R88	Chemotaxis protein (CheV)
HPY12_RS06575	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HPY12_RS06580	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HPY12_RS06585	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HPY12_RS06590	ENOG4106TD9	Diguanylate cyclase
HPY12_RS06595	ENOG4105BZU	Histidine kinase
HPY12_RS06605	ENOG4105C7K	acetolactate synthase
HPY12_RS06610	ENOG4107FQX	Alpha-acetolactate decarboxylase
HPY12_RS06625	ENOG4108TWJ	NADH dehydrogenase subunit 5
HPY12_RS06630	ENOG4105DUM	transcriptional regulator, lysR family
HPY12_RS06635	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
HPY12_RS06650	ENOG4105V0I	UPF0267 protein
HPY12_RS06665	ENOG4105C9Q	fumarate hydratase class II
HPY12_RS06675	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY12_RS06680	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY12_RS06685	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HPY12_RS06690	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY12_RS06695	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY12_RS06705	ENOG4107QZV	Type I secretion membrane fusion protein
HPY12_RS06725	ENOG4105CS2	ec 3.2.1.21
HPY12_RS06730	ENOG4105DDV	Transcriptional regulator (LacI family
HPY12_RS06735	ENOG4105M4H	endoribonuclease L-psp
HPY12_RS06740	ENOG4105XEP	YhcH YjgK YiaL family protein
HPY12_RS06745	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HPY12_RS06750	ENOG4105E98	transcriptional regulator DeoR family
HPY12_RS06755	ENOG4108IJ9	(ABC) transporter
HPY12_RS06760	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS06765	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HPY12_RS06790	ENOG4109015	Biopolymer transport protein exbD tolR
HPY12_RS06795	ENOG41067XB	TonB family
HPY12_RS06815	ENOG4107QI1	Mate efflux family protein
HPY12_RS06835	ENOG4107TT5	NLP P60 protein
HPY12_RS06840	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS06855	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
HPY12_RS06865	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY12_RS06870	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HPY12_RS06875	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS06880	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS06890	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS06895	ENOG4105BZU	Histidine kinase
HPY12_RS06900	ENOG4105C5H	ABC transporter
HPY12_RS06905	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HPY12_RS06925	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
HPY12_RS06935	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY12_RS06940	ENOG4105QAX	Iron-sulfur
HPY12_RS06955	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HPY12_RS06960	ENOG4108VPT	UPF0234 protein
HPY12_RS06965	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY12_RS06980	ENOG4105QNR	S1 RNA binding domain protein
HPY12_RS06995	ENOG4105H2K	paraquat-inducible protein a
HPY12_RS07000	ENOG4105BZ1	(ABC) transporter
HPY12_RS07005	ENOG4108ZGC	gaf domain protein
HPY12_RS07010	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
HPY12_RS07015	ENOG4105CN1	protease
HPY12_RS07025	ENOG4105CD8	aminopeptidase N
HPY12_RS07035	ENOG4105C7I	Dehydrogenase
HPY12_RS07040	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HPY12_RS07045	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
HPY12_RS07050	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HPY12_RS07060	ENOG4105C5H	ABC transporter
HPY12_RS07075	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
HPY12_RS07080	ENOG4105DAN	ATP-dependent protease
HPY12_RS07085	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
HPY12_RS07105	ENOG4108RS6	transposase
HPY12_RS07185	ENOG4105EUK	rtx toxin RtxA
HPY12_RS07190	ENOG4108RC6	RTX toxin
HPY12_RS07215	ENOG4105BZU	Histidine kinase
HPY12_RS07230	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HPY12_RS07245	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
HPY12_RS07255	ENOG4105C59	p-type ATPase
HPY12_RS07270	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HPY12_RS07275	ENOG4105Q9Y	Universal stress protein
HPY12_RS07280	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HPY12_RS07300	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS07310	ENOG4105D38	putrescine abc transporter
HPY12_RS07315	ENOG4108HM4	ABC transporter
HPY12_RS07320	ENOG4107RUE	extracellular solute-binding protein family 1
HPY12_RS07330	ENOG4105BZG	amino acid carrier protein
HPY12_RS07355	ENOG4105CS6	Rhs element vgr protein
HPY12_RS07360	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY12_RS07365	ENOG4105CTD	carboxy-peptidase
HPY12_RS07370	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS07375	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY12_RS07380	ENOG4105CW7	secretion protein, HlyD family
HPY12_RS07395	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS07400	ENOG4107SDU	Methyl-accepting chemotaxis
HPY12_RS07405	ENOG4108N3W	hemolysin secretion protein
HPY12_RS07410	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS07415	ENOG4108V3W	Chemotaxis protein, CheW
HPY12_RS07420	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY12_RS07430	ENOG4105BZU	Histidine kinase
HPY12_RS07440	ENOG4105CBS	Chea signal transduction histidine kinase
HPY12_RS07455	ENOG4108NVR	Methyl-accepting chemotaxis
HPY12_RS07460	ENOG4105KPY	Small multidrug resistance protein
HPY12_RS07465	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY12_RS07470	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HPY12_RS07475	ENOG4105EJC	lysr family transcriptional regulator
HPY12_RS07485	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
HPY12_RS07490	ENOG4105R8A	Heat shock protein
HPY12_RS07500	ENOG4105CQ7	ATP-dependent helicase
HPY12_RS07520	ENOG4105BZU	Histidine kinase
HPY12_RS07530	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY12_RS07535	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HPY12_RS07540	ENOG4105BZU	Histidine kinase
HPY12_RS07550	ENOG4105BZU	Histidine kinase
HPY12_RS07570	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HPY12_RS07575	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HPY12_RS07580	ENOG410667J	hydrolase
HPY12_RS07590	ENOG4107QXX	ABC transporter
HPY12_RS07595	ENOG4105EZ7	amino acid ABC transporter
HPY12_RS07600	ENOG4105DRP	amino acid AbC transporter
HPY12_RS07605	ENOG4105CDA	abc transporter atp-binding protein
HPY12_RS07610	ENOG4108MN8	Membrane
HPY12_RS07615	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HPY12_RS07620	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HPY12_RS07625	ENOG4105DR4	Methyltransferase
HPY12_RS07630	ENOG4106TD9	Diguanylate cyclase
HPY12_RS07640	ENOG4105BZU	Histidine kinase
HPY12_RS07645	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY12_RS07650	ENOG4108RXX	maleylacetoacetate isomerase
HPY12_RS07660	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HPY12_RS07665	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HPY12_RS07670	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY12_RS07685	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY12_RS07690	ENOG4105C7F	AcnD-accessory protein PrpF
HPY12_RS07695	ENOG4108I0Z	Aconitate hydratase
HPY12_RS07700	ENOG4105BZN	citrate synthase
HPY12_RS07705	ENOG4105CR4	methylisocitrate lyase
HPY12_RS07745	ENOG4105EFX	secretion protein, HlyD family
HPY12_RS07760	ENOG4107SDZ	Galactoside transport system permease protein mglC
HPY12_RS07765	ENOG4105C2J	ABC transporter
HPY12_RS07790	ENOG4107EXC	regulatoR
HPY12_RS07795	ENOG4105GR3	Histidine kinase
HPY12_RS07800	ENOG4105RW8	MltA-interacting MipA family protein
HPY12_RS07805	ENOG4108MJ5	VirK protein
HPY12_RS07810	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS07815	ENOG4105BZU	Histidine kinase
HPY12_RS07820	ENOG4105C8P	)-transporter
HPY12_RS07825	ENOG4108NVR	Methyl-accepting chemotaxis
HPY12_RS07830	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY12_RS07845	ENOG4105D9U	N-acetyltransferase
HPY12_RS07850	ENOG4108JU8	Transcriptional regulator
HPY12_RS07860	ENOG4105CM6	amino acid regulated cytosolic protein
HPY12_RS07875	ENOG4105CRQ	synthase (Component I)
HPY12_RS07880	ENOG4105P8F	nudix hydrolase
HPY12_RS07885	ENOG4105C44	Serine transporter
HPY12_RS07890	ENOG4105EJQ	L-serine dehydratase
HPY12_RS07895	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HPY12_RS07900	ENOG4108NVR	Methyl-accepting chemotaxis
HPY12_RS07905	ENOG4105C5S	asparaginyl-tRNA synthetase
HPY12_RS07915	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HPY12_RS07920	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY12_RS07935	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS07940	ENOG4105DJ9	glucan biosynthesis protein
HPY12_RS07945	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HPY12_RS07950	ENOG41060NJ	transcriptional regulator
HPY12_RS07955	ENOG410901P	UPF0249 protein
HPY12_RS07960	ENOG4105F8D	glycoside hydrolase family 4
HPY12_RS07965	ENOG4105VCP	PTS System
HPY12_RS07975	ENOG4105VZJ	PTS System
HPY12_RS07985	ENOG4105C94	Transporter
HPY12_RS08005	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HPY12_RS08015	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY12_RS08030	ENOG4105C5X	domain protein
HPY12_RS08035	ENOG4105EAQ	(twin-arginine translocation) pathway signal
HPY12_RS08065	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
HPY12_RS08075	ENOG4105S8Q	sugar efflux transporter
HPY12_RS08085	ENOG4105C72	UPF0176 protein
HPY12_RS08090	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HPY12_RS08095	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HPY12_RS08100	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY12_RS08105	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HPY12_RS08110	ENOG4107QK7	reductase
HPY12_RS08135	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS08150	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS08155	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
HPY12_RS08170	ENOG4108YZT	Adenosylcobinamide kinase
HPY12_RS08175	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HPY12_RS08180	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HPY12_RS08185	ENOG4105E0X	reductase
HPY12_RS08190	ENOG4108ETY	sodium dicarboxylate symporter
HPY12_RS08195	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HPY12_RS08200	ENOG4105KT5	UmuD protein
HPY12_RS08365	ENOG4106CVF	DNA replication protein
HPY12_RS08410	ENOG4106V8H	Nucleoid-associated protein
HPY12_RS08435	ENOG4105DFP	Integrase
HPY12_RS08440	ENOG4105CJB	Exodeoxyribonuclease I
HPY12_RS08445	ENOG4105VAW	lrga family
HPY12_RS08450	ENOG41067MG	lrgb family
HPY12_RS08480	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HPY12_RS08485	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HPY12_RS08490	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HPY12_RS08530	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HPY12_RS08535	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY12_RS08540	ENOG4105CQ2	DNA polymerase
HPY12_RS08545	ENOG4105BZU	Histidine kinase
HPY12_RS08555	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HPY12_RS08560	ENOG4108W5H	UPF0263 protein
HPY12_RS08570	ENOG4105CZE	histidine utilization repressor
HPY12_RS08575	ENOG4105CI2	imidazolone-5-propionate hydrolase
HPY12_RS08580	ENOG41088SP	formiminoglutamate hydrolase
HPY12_RS08585	ENOG4105CGP	Urocanate hydratase
HPY12_RS08590	ENOG4105C84	Histidine ammonia-lyase
HPY12_RS08600	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
HPY12_RS08610	ENOG4105CQB	FAD linked oxidase domain protein
HPY12_RS08625	ENOG4108ZG0	Ompa motb domain protein
HPY12_RS08645	ENOG4105C8V	SAICAR synthetase
HPY12_RS08655	ENOG4107R1I	NAD-dependent malic enzyme
HPY12_RS08665	ENOG4107GZ4	SanA protein
HPY12_RS08675	ENOG4105C9B	Cysteine desulfurase
HPY12_RS08685	ENOG4105C3M	thioredoxin reductase
HPY12_RS08690	ENOG4108JJ9	ABC, transporter
HPY12_RS08695	ENOG4108JJ8	(ABC) transporter
HPY12_RS08700	ENOG4105FE9	pseudouridine synthase
HPY12_RS08705	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HPY12_RS08710	ENOG4105DB7	PHP domain protein
HPY12_RS08720	ENOG4105CRQ	synthase (Component I)
HPY12_RS08725	ENOG4105DDQ	anthranilate synthase
HPY12_RS08730	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HPY12_RS08735	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HPY12_RS08740	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HPY12_RS08745	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HPY12_RS08750	ENOG4105CK2	sodium dicarboxylate symporter
HPY12_RS08755	ENOG4107104	thymidine kinase
HPY12_RS08760	ENOG4105C9M	aspartyl-trna synthetase
HPY12_RS08765	ENOG41081XQ	Conserved Protein
HPY12_RS08770	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HPY12_RS08775	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
HPY12_RS08780	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY12_RS08795	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HPY12_RS08805	ENOG4105CUX	Signal transduction histidine kinase
HPY12_RS08830	ENOG4105DWU	Membrane
HPY12_RS08840	ENOG4105DY8	decarboxylase
HPY12_RS08845	ENOG4106KNT	transcriptional regulator
HPY12_RS08850	ENOG4105C0A	alcohol dehydrogenase
HPY12_RS08855	ENOG41090BQ	Glutaredoxin
HPY12_RS08860	ENOG4105D0C	transport protein
HPY12_RS08865	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY12_RS08870	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HPY12_RS08875	ENOG4105VEQ	Cold shock protein
HPY12_RS08885	ENOG4108R99	pseudouridine synthase
HPY12_RS08890	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HPY12_RS08895	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HPY12_RS08900	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HPY12_RS08905	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HPY12_RS08910	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HPY12_RS08915	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HPY12_RS08920	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HPY12_RS08925	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HPY12_RS08930	ENOG4107S6Z	Na H antiporter
HPY12_RS08940	ENOG4107RE1	Inosine-guanosine kinase
HPY12_RS08945	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HPY12_RS08950	ENOG41075W9	High frequency lysogenization protein HflD homolog
HPY12_RS08955	ENOG4107QTF	adenylosuccinate lyase
HPY12_RS08975	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HPY12_RS08990	ENOG4107FW0	short-chain dehydrogenase reductase
HPY12_RS09000	ENOG4105D0M	Protease HtpX homolog
HPY12_RS09010	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HPY12_RS09015	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HPY12_RS09020	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY12_RS09025	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HPY12_RS09030	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HPY12_RS09035	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HPY12_RS09040	ENOG4105D1H	recombination factor protein RarA
HPY12_RS09050	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HPY12_RS09055	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HPY12_RS09060	ENOG4105BZU	Histidine kinase
HPY12_RS09065	ENOG4108JJB	ABC transporter
HPY12_RS09070	ENOG4105C7J	ABC transporter, permease
HPY12_RS09080	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HPY12_RS09085	ENOG4105PQ6	UPF0208 membrane protein
HPY12_RS09090	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY12_RS09095	ENOG4108DNC	Involved in acetate metabolism (By similarity)
HPY12_RS09100	ENOG4105CHF	Glutathione S-transferase
HPY12_RS09105	ENOG4108JQ7	(ABC) transporter
HPY12_RS09110	ENOG4105C3U	ABC transporter
HPY12_RS09115	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS09120	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS09125	ENOG4107QSI	ABC, transporter
HPY12_RS09140	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS09145	ENOG4105BZU	Histidine kinase
HPY12_RS09150	ENOG4105BZU	Histidine kinase
HPY12_RS09155	ENOG4105BZU	Histidine kinase
HPY12_RS09165	ENOG4107YTP	response regulator receiver protein
HPY12_RS09180	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY12_RS09195	ENOG4108V1U	phospholipid-binding protein
HPY12_RS09220	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY12_RS09225	ENOG41082YX	Transcriptional regulator, arsr family
HPY12_RS09235	ENOG4105BZU	Histidine kinase
HPY12_RS09255	ENOG4105C29	acyl-CoA thioesterase
HPY12_RS09260	ENOG4108XM1	transcriptional regulator AsnC family
HPY12_RS09270	ENOG4105ERU	peptidase
HPY12_RS09275	ENOG4105UBK	short-chain dehydrogenase reductase
HPY12_RS09280	ENOG4108ZZ3	UPF0260 protein
HPY12_RS09285	ENOG4105KRS	Proteinase inhibitor
HPY12_RS09290	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HPY12_RS09295	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HPY12_RS09300	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HPY12_RS09305	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HPY12_RS09310	ENOG4105WD1	Membrane
HPY12_RS09315	ENOG4105I93	response regulator
HPY12_RS09320	ENOG4105EJC	lysr family transcriptional regulator
HPY12_RS09325	ENOG41069NU	Nitroreductase
HPY12_RS09330	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY12_RS09335	ENOG4105CHU	acetyl-coa acetyltransferase
HPY12_RS09350	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY12_RS09355	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY12_RS09365	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HPY12_RS09375	ENOG4108GAE	asmA family
HPY12_RS09380	ENOG4105DBI	uridine monophosphokinase
HPY12_RS09385	ENOG4105D1F	ATP-binding protein
HPY12_RS09390	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HPY12_RS09400	ENOG4108I5U	Uridine phosphorylase
HPY12_RS09415	ENOG4105BZU	Histidine kinase
HPY12_RS09420	ENOG4108ZAF	Molybdopterin
HPY12_RS09425	ENOG4105M00	molybdopterin converting factor, subunit 1
HPY12_RS09430	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY12_RS09435	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HPY12_RS09440	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HPY12_RS09445	ENOG4105CHW	UPF0052 protein
HPY12_RS09455	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS09460	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HPY12_RS09470	ENOG4105DFP	Integrase
HPY12_RS09500	ENOG4108YGG	dna repair protein
HPY12_RS09540	ENOG4105D5K	Hemolysin activator protein
HPY12_RS09555	ENOG4105JXR	Protein of unknown function (DUF3296)
HPY12_RS09575	ENOG4108R3D	Electron transport complex
HPY12_RS09595	ENOG4105DZB	Electron transport complex
HPY12_RS09600	ENOG4105CSM	endonuclease III
HPY12_RS09605	ENOG4108UYE	Lactoylglutathione lyase
HPY12_RS09610	ENOG4106WH9	Protein of unknown function (DUF2753)
HPY12_RS09615	ENOG4105EIY	sodium-type flagellar protein motY
HPY12_RS09625	ENOG4105D3Y	Na H antiporter
HPY12_RS09630	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HPY12_RS09635	ENOG4105E96	Colicin v production protein
HPY12_RS09640	ENOG4108S3P	Sporulation domain protein
HPY12_RS09645	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HPY12_RS09650	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HPY12_RS09655	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HPY12_RS09670	ENOG4105CI1	PTS System
HPY12_RS09675	ENOG4105CE4	GlcNAc 6-P deacetylase
HPY12_RS09680	ENOG4105E2R	ROK family
HPY12_RS09685	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HPY12_RS09690	ENOG4105CAQ	asparagine synthetase
HPY12_RS09695	ENOG4105MDZ	Transcriptional activator rfaH
HPY12_RS09700	ENOG4105DUX	Transporter
HPY12_RS09705	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HPY12_RS09710	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HPY12_RS09715	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HPY12_RS09720	ENOG4108TU9	TRANSCRIPTIONal
HPY12_RS09735	ENOG4108RE9	Phosphodiesterase
HPY12_RS09740	ENOG4105ECP	epimerase
HPY12_RS09745	ENOG4105E1F	short-chain dehydrogenase reductase
HPY12_RS09750	ENOG4107QR8	Thioredoxin
HPY12_RS09755	ENOG4107QX8	SPFH domain, Band 7 family protein
HPY12_RS09760	ENOG4105G5H	Membrane
HPY12_RS09765	ENOG4108Z6Z	Transcriptional regulator
HPY12_RS09775	ENOG41081QG	Porin Gram-negative type
HPY12_RS09780	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HPY12_RS09785	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
HPY12_RS09790	ENOG4105EXN	Sulfate transport protein CysZ
HPY12_RS09800	ENOG4105KZ7	phosphocarrier protein hpr
HPY12_RS09805	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HPY12_RS09810	ENOG4105C5Y	PTS System
HPY12_RS09815	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
HPY12_RS09820	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HPY12_RS09825	ENOG4105C9A	Phoh family
HPY12_RS09830	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HPY12_RS09835	ENOG4108JU5	Magnesium and cobalt efflux protein
HPY12_RS09840	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HPY12_RS09845	ENOG4107PAI	alpha helical protein
HPY12_RS09850	ENOG4105C8T	Leucyl-tRNA synthetase
HPY12_RS09855	ENOG4108U2H	Rare lipoprotein B
HPY12_RS09885	ENOG4105K6T	rare lipoprotein A
HPY12_RS09890	ENOG4105DZ1	carboxypeptidase
HPY12_RS09895	ENOG4108Z43	UPF0250 protein
HPY12_RS09900	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HPY12_RS09905	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HPY12_RS09915	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY12_RS09940	ENOG4105DAY	polysaccharide export protein
HPY12_RS09950	ENOG4105D3Q	Sugar transferase
HPY12_RS09965	ENOG4108MA4	Peptidase M66
HPY12_RS09980	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
HPY12_RS09990	ENOG4105Q84	sucrose synthase
HPY12_RS10020	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HPY12_RS10025	ENOG4105KJF	protein tyrosine phosphatase
HPY12_RS10030	ENOG4105BZS	acriflavin resistance protein
HPY12_RS10060	ENOG4105CG3	alpha amylase, catalytic region
HPY12_RS10065	ENOG4105C5Y	PTS System
HPY12_RS10070	ENOG4105D4X	repressor
HPY12_RS10075	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HPY12_RS10080	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS10085	ENOG4108UMI	ABC transporter, permease
HPY12_RS10090	ENOG4105D01	(LipO)protein
HPY12_RS10095	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
HPY12_RS10100	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
HPY12_RS10105	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HPY12_RS10115	ENOG4105BZU	Histidine kinase
HPY12_RS10120	ENOG4105EWT	decarboxylase family
HPY12_RS10125	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
HPY12_RS10130	ENOG4105M08	Membrane
HPY12_RS10135	ENOG4105ETT	transcriptional Regulator, LysR family
HPY12_RS10140	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HPY12_RS10145	ENOG4106VK6	Flagellar motor protein
HPY12_RS10150	ENOG4105E14	MotA TolQ exbB proton channel
HPY12_RS10160	ENOG4105CTB	Polyprenyl synthetase
HPY12_RS10165	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HPY12_RS10170	ENOG4105DR9	pseudouridine synthase
HPY12_RS10175	ENOG4105WP7	tRNA pseudouridine synthase C
HPY12_RS10190	ENOG4108428	Inherit from COG: -acetyltransferase
HPY12_RS10200	ENOG4108UPT	UPF0178 protein
HPY12_RS10215	ENOG4105NRA	50s ribosomal protein l31 type b
HPY12_RS10220	ENOG4108R96	Methyltransferase, YaeB family
HPY12_RS10225	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HPY12_RS10245	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HPY12_RS10255	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HPY12_RS10260	ENOG4108Z6B	deaminase
HPY12_RS10265	ENOG4105CFC	Transporter
HPY12_RS10295	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY12_RS10300	ENOG4105CFG	Acts as a chaperone (By similarity)
HPY12_RS10310	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY12_RS10315	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HPY12_RS10320	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HPY12_RS10325	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY12_RS10330	ENOG4105VDB	UPF0125 protein
HPY12_RS10335	ENOG4108Z1B	Cyclase dehydrase
HPY12_RS10340	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HPY12_RS10440	ENOG4105DZ0	fad dependent oxidoreductase
HPY12_RS10445	ENOG4108Z4U	Ferredoxin
HPY12_RS10470	ENOG4105CHY	citrate lyase, alpha
HPY12_RS10475	ENOG4105CI0	Citrate lyase
HPY12_RS10485	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
HPY12_RS10490	ENOG4105D2K	citrate carrier protein
HPY12_RS10500	ENOG4107QSA	Oxaloacetate decarboxylase
HPY12_RS10505	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY12_RS10510	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HPY12_RS10515	ENOG4106YYS	transcriptional regulatory protein
HPY12_RS10530	ENOG4105F04	LysR family Transcriptional regulator
HPY12_RS10540	ENOG4105BZG	amino acid carrier protein
HPY12_RS10545	ENOG4105EUZ	Beta-lactamase domain protein
HPY12_RS10550	ENOG41064T2	transcriptional regulator, lysR family
HPY12_RS10560	ENOG4105E0A	ABC, transporter
HPY12_RS10565	ENOG4105TVJ	transport system, permease
HPY12_RS10570	ENOG4105DQ5	transport system permease protein
HPY12_RS10575	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HPY12_RS10585	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HPY12_RS10590	ENOG4105E4F	Isochorismate synthase
HPY12_RS10595	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
HPY12_RS10600	ENOG4105WQI	isochorismatase
HPY12_RS10605	ENOG4106HK8	GPR1 FUN34 yaaH family protein
HPY12_RS10615	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HPY12_RS10620	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY12_RS10625	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HPY12_RS10640	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HPY12_RS10645	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HPY12_RS10650	ENOG4105N21	Membrane
HPY12_RS10655	ENOG4105CUT	histidyl-tRNA synthetase
HPY12_RS10660	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HPY12_RS10665	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
HPY12_RS10675	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HPY12_RS10680	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HPY12_RS10685	ENOG4105WVQ	Fe-S assembly protein IscX
HPY12_RS10690	ENOG4108ZIT	Ferredoxin, 2FE-2S
HPY12_RS10705	ENOG4108Z4V	iron-sulfur cluster assembly
HPY12_RS10710	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HPY12_RS10720	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HPY12_RS10725	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
HPY12_RS10730	ENOG4105ECY	inositol monophosphatase
HPY12_RS10735	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY12_RS10740	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY12_RS10745	ENOG4105VIE	preprotein translocase, subunit YajC
HPY12_RS10755	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HPY12_RS10760	ENOG4105W87	Cbs domain
HPY12_RS10765	ENOG4108I9X	Isocitrate lyase
HPY12_RS10770	ENOG4107QP3	malate synthase g
HPY12_RS10775	ENOG4105C5Q	Transcriptional regulator
HPY12_RS10780	ENOG4105D3R	alkyl hydroperoxide reductase
HPY12_RS10785	ENOG4106N3A	copper homeostasis protein cutc
HPY12_RS10790	ENOG4105CSR	polyphosphate kinase 2
HPY12_RS10800	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS10805	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY12_RS10810	ENOG4105C8U	phosphate abc transporter
HPY12_RS10815	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HPY12_RS10820	ENOG4105C9X	ppx gppa phosphatase
HPY12_RS10825	ENOG4105DJH	phosphate
HPY12_RS10830	ENOG4105BZU	Histidine kinase
HPY12_RS10835	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY12_RS10845	ENOG4105CFP	Peptidase U32
HPY12_RS10850	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HPY12_RS10890	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY12_RS10895	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HPY12_RS10900	ENOG4105C34	Pseudouridine synthase
HPY12_RS10905	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY12_RS10910	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
HPY12_RS10920	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
HPY12_RS10925	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY12_RS10935	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
HPY12_RS10940	ENOG4107SC1	transglycosylase
HPY12_RS10945	ENOG4105C5H	ABC transporter
HPY12_RS10960	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY12_RS10965	ENOG4108HRK	Histidine kinase
HPY12_RS10970	ENOG4108NEV	two component transcriptional regulator, LytTR family
HPY12_RS10980	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HPY12_RS10985	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY12_RS11005	ENOG4108RS6	transposase
HPY12_RS11010	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HPY12_RS11015	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HPY12_RS11020	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HPY12_RS11030	ENOG4105DTN	riboflavin biosynthesis protein ribF
HPY12_RS11035	ENOG4105CJR	Integral membrane protein (MviN
HPY12_RS11040	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HPY12_RS11045	ENOG41080HT	Transcriptional regulator, arsr family
HPY12_RS11050	ENOG41063Z6	transcriptional regulator, lysR family
HPY12_RS11060	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HPY12_RS11065	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HPY12_RS11070	ENOG4105HF0	Membrane
HPY12_RS11075	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
HPY12_RS11080	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HPY12_RS11085	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
HPY12_RS11090	ENOG4105CPC	Aldo Keto reductase
HPY12_RS11100	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS11105	ENOG4105CRK	lysyL-tRNA synthetase
HPY12_RS11115	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HPY12_RS11125	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS11135	ENOG4105BZU	Histidine kinase
HPY12_RS11150	ENOG4108YYD	acetyltransferase
HPY12_RS11160	ENOG4105BZU	Histidine kinase
HPY12_RS11195	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HPY12_RS11205	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HPY12_RS11210	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HPY12_RS11215	ENOG4105CHV	Transcription elongation factor NusA
HPY12_RS11220	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HPY12_RS11235	ENOG4105NTZ	Preprotein translocase subunit SecG
HPY12_RS11245	ENOG4105EEI	dihydropteroate synthase
HPY12_RS11250	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HPY12_RS11255	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HPY12_RS11260	ENOG4105HBR	Rna-binding protein
HPY12_RS11265	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HPY12_RS11270	ENOG4105FCK	Membrane
HPY12_RS11275	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
HPY12_RS11280	ENOG4108RS6	transposase
HPY12_RS11285	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY12_RS11290	ENOG4105DR5	peptidase
HPY12_RS11305	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HPY12_RS11310	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HPY12_RS11315	ENOG4105IPI	Membrane
HPY12_RS11320	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HPY12_RS11330	ENOG4107QRA	Extracellular solute-binding protein, family 5
HPY12_RS11340	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS11345	ENOG4105C3U	ABC transporter
HPY12_RS11350	ENOG4108JQ7	(ABC) transporter
HPY12_RS11360	ENOG4105RD7	BadF BadG BcrA BcrD
HPY12_RS11365	ENOG4105E2D	ec 3.2.1.52
HPY12_RS11370	ENOG4105E2V	Glycosyltransferase 36
HPY12_RS11380	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS11405	ENOG4105XTV	UPF0231 protein
HPY12_RS11410	ENOG4107QIJ	Aconitate hydratase 2
HPY12_RS11415	ENOG4105D78	K07001 NTE family protein
HPY12_RS11420	ENOG4105BZ4	penicillin-binding protein
HPY12_RS11425	ENOG4105CQ7	ATP-dependent helicase
HPY12_RS11435	ENOG4105PW4	Sugar fermentation stimulation protein homolog
HPY12_RS11440	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPY12_RS11445	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HPY12_RS11450	ENOG4105DJ0	Poly(A) Polymerase
HPY12_RS11455	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY12_RS11460	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HPY12_RS11465	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HPY12_RS11470	ENOG4105E3A	(ABC) transporter
HPY12_RS11475	ENOG4105DA5	(ABC) transporter
HPY12_RS11480	ENOG4105CHH	sulfate transporter
HPY12_RS11485	ENOG41077A9	carbonic anhydrase
HPY12_RS11490	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HPY12_RS11495	ENOG410630P	Transcriptional regulator
HPY12_RS11500	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HPY12_RS11505	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
HPY12_RS11510	ENOG41082RQ	UPF0102 protein
HPY12_RS11515	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HPY12_RS11520	ENOG4105W4M	Transport-associated protein
HPY12_RS11525	ENOG4105KB2	stringent starvation protein b
HPY12_RS11530	ENOG4107MKT	Stringent starvation protein a
HPY12_RS11535	ENOG4105EIX	cytochrome c1
HPY12_RS11540	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY12_RS11545	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HPY12_RS11550	ENOG4108UJD	30S ribosomal protein S9
HPY12_RS11555	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HPY12_RS11560	ENOG4105D6Z	AFG1 family ATPase
HPY12_RS11570	ENOG4105C0H	protease
HPY12_RS11575	ENOG4105C0H	protease
HPY12_RS11580	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HPY12_RS11585	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HPY12_RS11590	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HPY12_RS11595	ENOG4105K5M	30s ribosomal protein S16
HPY12_RS11600	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY12_RS11605	ENOG4106KVJ	cytochrome C assembly protein
HPY12_RS11610	ENOG4108JU6	CBS domain protein
HPY12_RS11615	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HPY12_RS11620	ENOG4105D9M	gamma-glutamylcysteine synthetase
HPY12_RS11630	ENOG4105W39	Membrane
HPY12_RS11640	ENOG4105D9Q	decarboxylase (Beta subunit)
HPY12_RS11645	ENOG4107QSA	Oxaloacetate decarboxylase
HPY12_RS11695	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
HPY12_RS11700	ENOG4105CFH	Aspartokinase
HPY12_RS11705	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HPY12_RS11710	ENOG4105Y3E	Modulates RecA activity (By similarity)
HPY12_RS11715	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HPY12_RS11725	ENOG4108IJ6	ABC transporter
HPY12_RS11730	ENOG4105ECW	sulfate abc transporter
HPY12_RS11735	ENOG4108I5D	sulfate abc transporter
HPY12_RS11740	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY12_RS11745	ENOG4105C6T	cysteine synthase
HPY12_RS11755	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY12_RS11760	ENOG4108K5P	(LipO)protein
HPY12_RS11765	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HPY12_RS11770	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HPY12_RS11775	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
HPY12_RS11780	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HPY12_RS11785	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HPY12_RS11795	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HPY12_RS11800	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY12_RS11805	ENOG4107ZVW	dihydroneopterin aldolase
HPY12_RS11810	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HPY12_RS11820	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HPY12_RS11825	ENOG4105VCC	30S ribosomal protein S21
HPY12_RS11830	ENOG4105KTH	gatB Yqey
HPY12_RS11835	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HPY12_RS11840	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HPY12_RS11855	ENOG4105CH5	extracellular solute-binding protein, family 7
HPY12_RS11860	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HPY12_RS11865	ENOG410804X	Transcriptional regulator
HPY12_RS11870	ENOG4105CA9	Pyruvate kinase
HPY12_RS11875	ENOG4105MPN	Membrane
HPY12_RS11885	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
HPY12_RS11890	ENOG4105D64	Mechanosensitive ion channel
HPY12_RS11895	ENOG4105D2N	Aldolase
HPY12_RS11905	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HPY12_RS11910	ENOG4105D05	Receptor
HPY12_RS11915	ENOG4108R4R	Iron-regulated virulence regulatory protein
HPY12_RS11920	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY12_RS11925	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HPY12_RS11930	ENOG4105GPY	SprT protein
HPY12_RS11935	ENOG4105RWS	endonuclease I
HPY12_RS11940	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HPY12_RS11945	ENOG4105D7Z	glutathione synthase
HPY12_RS11950	ENOG4108UJU	UPF0301 protein
HPY12_RS11955	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HPY12_RS11960	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HPY12_RS11970	ENOG4105CZX	twitching motility protein
HPY12_RS11975	ENOG4105CZX	twitching motility protein
HPY12_RS11980	ENOG4105DFA	alanine racemase domain protein
HPY12_RS11985	ENOG4105II7	pyrroline-5-carboxylate reductase
HPY12_RS11990	ENOG4108VIA	integral membrane protein
HPY12_RS12005	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HPY12_RS12010	ENOG4105CSA	Coproporphyrinogen iii oxidase
HPY12_RS12015	ENOG4105CSV	Glutaminase
HPY12_RS12020	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HPY12_RS12025	ENOG4105CEN	a g-specific adenine glycosylase
HPY12_RS12030	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HPY12_RS12035	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HPY12_RS12090	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HPY12_RS12095	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HPY12_RS12100	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HPY12_RS12105	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HPY12_RS12110	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HPY12_RS12115	ENOG4105NWN	ApaG protein
HPY12_RS12120	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HPY12_RS12130	ENOG4107XM3	UPF0442 protein
HPY12_RS12135	ENOG4105DWK	Membrane
HPY12_RS12140	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY12_RS12145	ENOG4105K46	50S ribosomal protein l27
HPY12_RS12150	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HPY12_RS12155	ENOG4105EAH	synthase
HPY12_RS12160	ENOG4105D5Q	Arginine ornithine antiporter
HPY12_RS12165	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HPY12_RS12170	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
HPY12_RS12175	ENOG4105H1G	trap transporter solute receptor taxi family
HPY12_RS12185	ENOG41081QV	Universal stress protein
HPY12_RS12205	ENOG4105CEU	Arginine dihydrolase
HPY12_RS12210	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HPY12_RS12220	ENOG4105QD6	exported protein
HPY12_RS12225	ENOG4105C03	ribonuclease
HPY12_RS12230	ENOG4108Z03	MAF-like protein
HPY12_RS12235	ENOG4105VQ7	Rod shape-determining protein MreD
HPY12_RS12240	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HPY12_RS12280	ENOG4105X0D	Fimbrial protein
HPY12_RS12290	ENOG4105D7Q	type ii secretion system
HPY12_RS12310	ENOG4105E4G	Type IV pilus
HPY12_RS12330	ENOG41062P1	Diguanylate cyclase phosphodiesterase
HPY12_RS12335	ENOG4108UUM	single-stranded DNA-binding protein
HPY12_RS12340	ENOG41086KC	Transcriptional regulator
HPY12_RS12345	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HPY12_RS12350	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HPY12_RS12360	ENOG4105C5R	Aminotransferase
HPY12_RS12365	ENOG4105CFH	Aspartokinase
HPY12_RS12370	ENOG4105C3R	Methionine synthase
HPY12_RS12375	ENOG4105EEQ	Na H antiporter
HPY12_RS12410	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HPY12_RS12415	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HPY12_RS12420	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
HPY12_RS12440	ENOG4105P4Z	Phage shock protein G
HPY12_RS12445	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY12_RS12450	ENOG4105MYN	Zinc uptake regulation protein
HPY12_RS12465	ENOG4107QP8	phosphohexose isomerase
HPY12_RS12500	ENOG4105DZR	Type I site-specific deoxyribonuclease
HPY12_RS12545	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HPY12_RS12555	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HPY12_RS12560	ENOG4105CDU	Replicative dna helicase
HPY12_RS12570	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HPY12_RS12575	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HPY12_RS12580	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
HPY12_RS12585	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HPY12_RS12590	ENOG4108UQY	Iron-storage protein
HPY12_RS12595	ENOG4105W53	bacterioferritin-associated ferredoxin
HPY12_RS12600	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY12_RS12605	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HPY12_RS12610	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HPY12_RS12625	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
HPY12_RS12630	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
HPY12_RS12635	ENOG4105WWK	YheO domain protein
HPY12_RS12640	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY12_RS12650	ENOG41069P5	Protein slyX homolog
HPY12_RS12660	ENOG4105EPW	hflc protein
HPY12_RS12665	ENOG4107QJR	hflk protein
HPY12_RS12670	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HPY12_RS12675	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HPY12_RS12680	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HPY12_RS12685	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HPY12_RS12690	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HPY12_RS12695	ENOG4105K8N	protein family UPF0079, ATPase
HPY12_RS12700	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HPY12_RS12750	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HPY12_RS12755	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HPY12_RS12760	ENOG4105DJ4	phosphatidylserine decarboxylase
HPY12_RS12765	ENOG4105C8P	)-transporter
HPY12_RS12775	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HPY12_RS12780	ENOG41063SB	peptidase
HPY12_RS12790	ENOG41062JF	Transcriptional regulator
HPY12_RS12795	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HPY12_RS12800	ENOG4105E09	nadh pyrophosphatase
HPY12_RS12805	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
HPY12_RS12810	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY12_RS12815	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HPY12_RS12820	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HPY12_RS12825	ENOG4108VZM	50s ribosomal protein L10
HPY12_RS12835	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HPY12_RS12840	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HPY12_RS12845	ENOG4105PM1	preprotein translocase subunit SecE
HPY12_RS12850	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HPY12_RS12875	ENOG4105CS9	pantothenic acid kinase
HPY12_RS12880	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HPY12_RS12885	ENOG4105D4A	Cell wall formation (By similarity)
HPY12_RS12895	ENOG4105JIM	Phosphatidylserine synthase
HPY12_RS12960	ENOG4107QK7	reductase
HPY12_RS12970	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HPY12_RS12980	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HPY12_RS12990	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS12995	ENOG4105C9X	ppx gppa phosphatase
HPY12_RS13000	ENOG4105BZU	Histidine kinase
HPY12_RS13005	ENOG4105D8G	Major Facilitator superfamily
HPY12_RS13020	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY12_RS13025	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HPY12_RS13030	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HPY12_RS13040	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY12_RS13045	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HPY12_RS13050	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HPY12_RS13065	ENOG4105DIQ	Transcriptional regulator
HPY12_RS13070	ENOG4105C01	Dihydroxy-acid dehydratase
HPY12_RS13075	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HPY12_RS13080	ENOG4105C6Z	Gluconate
HPY12_RS13085	ENOG4108UHU	Aldolase
HPY12_RS13090	ENOG4105E0K	tonB-dependent siderophore receptor
HPY12_RS13105	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS13110	ENOG4105CXN	decarboxylase
HPY12_RS13115	ENOG4105D5Q	Arginine ornithine antiporter
HPY12_RS13120	ENOG4108M3R	transcriptional activator CadC
HPY12_RS13125	ENOG4105W1Y	Transcriptional regulator
HPY12_RS13140	ENOG4105C12	Phosphoribosylglycinamide synthetase
HPY12_RS13150	ENOG4105K70	DNA-binding protein
HPY12_RS13160	ENOG4105DKQ	ROK family
HPY12_RS13165	ENOG4105EIP	mannose-6-phosphate isomerase
HPY12_RS13170	ENOG4105R2J	Conserved Protein
HPY12_RS13175	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HPY12_RS13180	ENOG4108RG0	uracil-dna glycosylase
HPY12_RS13185	ENOG4105CUY	Mechanosensitive ion channel
HPY12_RS13190	ENOG4105CY0	Metallo-Beta-Lactamase
HPY12_RS13195	ENOG4105D3Q	Sugar transferase
HPY12_RS13220	ENOG4107TXM	Nad-dependent epimerase dehydratase
HPY12_RS13225	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HPY12_RS13235	ENOG4105CKK	Glycosyl transferase, family 2
HPY12_RS13250	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HPY12_RS13255	ENOG4105CEY	Amp-dependent synthetase and ligase
HPY12_RS13260	ENOG4105CHR	reductase
HPY12_RS13270	ENOG4105CHR	reductase
HPY12_RS13280	ENOG4108P1X	synthase
HPY12_RS13290	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HPY12_RS13315	ENOG4105EY8	ABC transporter
HPY12_RS13325	ENOG4107QKV	phosphomannomutase
HPY12_RS13330	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HPY12_RS13335	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HPY12_RS13340	ENOG4107T94	Endo-14-beta-xylanase
HPY12_RS13355	ENOG4105XA0	heptosyltransferase ii
HPY12_RS13365	ENOG4108ST3	glycosyltransferase
HPY12_RS13370	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HPY12_RS13400	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
HPY12_RS13405	ENOG4105DKP	glycosyl transferase, family 9
HPY12_RS13410	ENOG4106WTF	Glycosyl transferase, family 2
HPY12_RS13415	ENOG4105M5K	heptosyltransferase
HPY12_RS13420	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HPY12_RS13425	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HPY12_RS13435	ENOG4105W0E	50S ribosomal protein L33
HPY12_RS13440	ENOG4105KDC	50s ribosomal protein l28
HPY12_RS13445	ENOG4105W5Q	DNA repair protein (RadC
HPY12_RS13450	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS13455	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HPY12_RS13465	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HPY12_RS13470	ENOG4105D1S	lipid A biosynthesis
HPY12_RS13475	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HPY12_RS13480	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HPY12_RS13485	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HPY12_RS13490	ENOG4105DSJ	YicC domain protein
HPY12_RS13495	ENOG4108TEB	UPF0114 protein
HPY12_RS13500	ENOG4105C5Y	PTS System
HPY12_RS13505	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY12_RS13510	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HPY12_RS13515	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
HPY12_RS13520	ENOG4105J76	Periplasmic binding protein
HPY12_RS13525	ENOG4105E0A	ABC, transporter
HPY12_RS13530	ENOG4105E0K	tonB-dependent siderophore receptor
HPY12_RS13535	ENOG4105BZ1	(ABC) transporter
HPY12_RS13550	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HPY12_RS13555	ENOG4105FR1	rard protein
HPY12_RS13560	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY12_RS13565	ENOG4108DMH	HTH_ARAC
HPY12_RS13570	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY12_RS13575	ENOG4105C4R	Atp-dependent dna helicase
HPY12_RS13580	ENOG4105DGW	oligopeptidase A
HPY12_RS13585	ENOG4105D6S	protein involved in catabolism of external DNA
HPY12_RS13590	ENOG4105DC8	reductase
HPY12_RS13600	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS13605	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS13610	ENOG4105DEF	Extracellular solute-binding protein, family 5
HPY12_RS13650	ENOG4105MPD	Cytochrome
HPY12_RS13655	ENOG4105C4R	Atp-dependent dna helicase
HPY12_RS13660	ENOG4105Y7M	Transcriptional regulator, TetR family
HPY12_RS13665	ENOG410624X	efflux transporter, rnd family, mfp subunit
HPY12_RS13670	ENOG4105BZS	acriflavin resistance protein
HPY12_RS13675	ENOG4105W0Z	cytoplasmic protein
HPY12_RS13680	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HPY12_RS13685	ENOG4105EMY	transcriptional regulator
HPY12_RS13755	ENOG4108RR8	protoporphyrinogen oxidase
HPY12_RS13760	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HPY12_RS13765	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HPY12_RS13770	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HPY12_RS13775	ENOG4105CHU	acetyl-coa acetyltransferase
HPY12_RS13780	ENOG4105F52	Transcriptional regulator
HPY12_RS13785	ENOG4105CZQ	inner membrane transport protein YdhC
HPY12_RS13795	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HPY12_RS13800	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HPY12_RS13805	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HPY12_RS13810	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HPY12_RS13815	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY12_RS13820	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HPY12_RS13830	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HPY12_RS13835	ENOG410684E	atp synthase
HPY12_RS13840	ENOG4105FA0	parb-like partition protein
HPY12_RS13845	ENOG4107QJE	Chromosome Partitioning Protein
HPY12_RS13850	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HPY12_RS13855	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HPY12_RS13860	ENOG4105QTB	Flavodoxin
HPY12_RS13865	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HPY12_RS13870	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HPY12_RS13880	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HPY12_RS13895	ENOG4105E5Q	amino acid AbC transporter
HPY12_RS13900	ENOG4105EAB	amino acid AbC transporter
HPY12_RS13905	ENOG4106RMF	ParB family
HPY12_RS13935	ENOG4105CDY	transcriptional regulatory protein
HPY12_RS13940	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HPY12_RS13945	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS13950	ENOG4108YYI	Protein of unknown function (DUF2810)
HPY12_RS13955	ENOG41061ZR	Transcriptional regulator
HPY12_RS13960	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HPY12_RS13965	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HPY12_RS13970	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HPY12_RS13975	ENOG4108WC9	type VI secretion system effector, hcp1 family
HPY12_RS13980	ENOG4105CS6	Rhs element vgr protein
HPY12_RS14015	ENOG4105C8P	)-transporter
HPY12_RS14020	ENOG4108Q67	UPF0319 protein
HPY12_RS14040	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS14060	ENOG4105EYK	Phosphatidylglycerophosphatase B
HPY12_RS14065	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HPY12_RS14090	ENOG4105D6U	Sodium Glutamate Symporter
HPY12_RS14095	ENOG4105YE1	PilZ domain
HPY12_RS14110	ENOG4105EFX	secretion protein, HlyD family
HPY12_RS14115	ENOG4105KK7	inner membrane protein YiaW
HPY12_RS14120	ENOG4106TD9	Diguanylate cyclase
HPY12_RS14135	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HPY12_RS14140	ENOG4107SEY	Conserved Protein
HPY12_RS14150	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HPY12_RS14155	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
HPY12_RS14165	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS14170	ENOG4105CUG	Oligopeptidase b
HPY12_RS14200	ENOG4105CVA	phosphate
HPY12_RS14205	ENOG4105C8U	phosphate abc transporter
HPY12_RS14210	ENOG4105E2Z	phosphate ABC transporter (Permease
HPY12_RS14215	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS14220	ENOG4105BZU	Histidine kinase
HPY12_RS14230	ENOG4105DWD	nucleoside recognition domain protein
HPY12_RS14235	ENOG4105CHH	sulfate transporter
HPY12_RS14245	ENOG4105DR5	peptidase
HPY12_RS14250	ENOG4105BZU	Histidine kinase
HPY12_RS14255	ENOG4105EQ2	LysR family Transcriptional regulator
HPY12_RS14260	ENOG4105E5M	Multidrug resistance protein D
HPY12_RS14265	ENOG4108Z4X	TRANSCRIPTIONal
HPY12_RS14280	ENOG4105CK2	sodium dicarboxylate symporter
HPY12_RS14325	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HPY12_RS14330	ENOG4105D9R	oxidoreductase
HPY12_RS14340	ENOG4105BZU	Histidine kinase
HPY12_RS14345	ENOG4107VXZ	Hydrolase
HPY12_RS14355	ENOG4105D3G	Pseudouridine synthase
HPY12_RS14415	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HPY12_RS14420	ENOG4108JUB	Transcriptional regulator
HPY12_RS14445	ENOG4105CS6	Rhs element vgr protein
HPY12_RS14460	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HPY12_RS14465	ENOG4105C2J	ABC transporter
HPY12_RS14470	ENOG4105CNN	ABC, transporter
HPY12_RS14475	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HPY12_RS14480	ENOG4108RVA	ribokinase
HPY12_RS14485	ENOG4105ETE	Transcriptional regulator (LacI family
HPY12_RS14490	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
HPY12_RS14495	ENOG4108I5U	Uridine phosphorylase
HPY12_RS14505	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HPY12_RS14510	ENOG4105CXY	transporter
HPY12_RS14525	ENOG4105CQZ	Histidine kinase
HPY12_RS14530	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HPY12_RS14545	ENOG4105D5U	fad dependent oxidoreductase
HPY12_RS14555	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HPY12_RS14570	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
HPY12_RS14575	ENOG4105ETE	Transcriptional regulator (LacI family
HPY12_RS14585	ENOG4105KJM	monovalent cation h antiporter subunit g
HPY12_RS14590	ENOG41080TA	Multiple resistance and ph regulation protein f
HPY12_RS14595	ENOG4105SC1	monovalent cation H antiporter subunit E
HPY12_RS14600	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HPY12_RS14605	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HPY12_RS14610	ENOG4105D65	subunit l
HPY12_RS14620	ENOG4105Q9Y	Universal stress protein
HPY12_RS14625	ENOG4105CIC	tryptophan-specific transport protein
HPY12_RS14645	ENOG4105VRT	cytoplasmic protein
HPY12_RS14655	ENOG4105BZU	Histidine kinase
HPY12_RS14660	ENOG4105VEQ	Cold shock protein
HPY12_RS14695	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HPY12_RS14700	ENOG41069D7	Methyl-accepting chemotaxis
HPY12_RS14715	ENOG4105D9N	nucleoside
HPY12_RS14720	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HPY12_RS14730	ENOG4108JUA	Transcriptional regulator
HPY12_RS14735	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HPY12_RS14740	ENOG4105VEQ	Cold shock protein
HPY12_RS14760	ENOG4108UNF	response regulator
HPY12_RS14770	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HPY12_RS14775	ENOG4105C5I	Dehydrogenase
HPY12_RS14795	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HPY12_RS14805	ENOG410642W	LysR family Transcriptional regulator
HPY12_RS14815	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS14820	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
HPY12_RS14830	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HPY12_RS14840	ENOG4105BZU	Histidine kinase
HPY12_RS14850	ENOG4107S6Z	Na H antiporter
HPY12_RS14855	ENOG4105E5M	Multidrug resistance protein D
HPY12_RS14865	ENOG4105BZU	Histidine kinase
HPY12_RS14870	ENOG4105KUU	lipolytic protein G-D-S-L family
HPY12_RS14875	ENOG4106M3D	hemolysin
HPY12_RS14880	ENOG4108N3W	hemolysin secretion protein
HPY12_RS14885	ENOG4107IFA	Lipase (EC 3.1.1.3)
HPY12_RS14915	ENOG4105DHS	permease protein
HPY12_RS14920	ENOG4105CM4	permease protein
HPY12_RS14925	ENOG4108IPW	abc transporter atp-binding protein
HPY12_RS14945	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HPY12_RS14965	ENOG4105ETX	regulatoR
HPY12_RS14975	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HPY12_RS14985	ENOG410667J	hydrolase
HPY12_RS15040	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY12_RS15045	ENOG4105BZU	Histidine kinase
HPY12_RS15085	ENOG4105C2C	drug resistance transporter, Bcr CflA
HPY12_RS15090	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS15100	ENOG4105DZ1	carboxypeptidase
HPY12_RS15120	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY12_RS15125	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HPY12_RS15130	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HPY12_RS15140	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HPY12_RS15150	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HPY12_RS15155	ENOG41082NX	50s ribosomal protein l35
HPY12_RS15160	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HPY12_RS15200	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HPY12_RS15255	ENOG4108HYG	acetyltransferase
HPY12_RS15285	ENOG4105FFM	Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity)
HPY12_RS15290	ENOG41080ET	plasmid maintenance system killer protein
HPY12_RS15295	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
HPY12_RS15365	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY12_RS15375	ENOG4105QNF	Outer membrane lipoprotein
HPY12_RS15380	ENOG4105QNF	Outer membrane lipoprotein
HPY12_RS15390	ENOG4105D9U	N-acetyltransferase
HPY12_RS15410	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
HPY12_RS15425	ENOG4105KD7	acetyltransferase
HPY12_RS15450	ENOG41068WN	
HPY12_RS15485	ENOG4105D9U	N-acetyltransferase
HPY12_RS15550	ENOG41080ET	plasmid maintenance system killer protein
HPY12_RS15555	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
HPY12_RS15600	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HPY12_RS15630	ENOG4105EST	Metal Dependent Phosphohydrolase
HPY12_RS15650	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY12_RS15720	ENOG4108RS6	transposase
HPY12_RS15760	ENOG4108RS6	transposase
HPY12_RS15820	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HPY12_RS15835	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HPY12_RS15840	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HPY12_RS15845	ENOG4105CGF	Aromatic amino acid aminotransferase
HPY12_RS15850	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HPY12_RS15855	ENOG4105DM4	PTS System
HPY12_RS15860	ENOG4105DE4	1-phosphofructokinase
HPY12_RS15865	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HPY12_RS15870	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
HPY12_RS15875	ENOG4107RFY	SbcCD D subunit
HPY12_RS15880	ENOG4105EYH	Exonuclease
HPY12_RS15885	ENOG4108MGY	Histidine kinase
HPY12_RS15890	ENOG4107KBT	8-Amino-7-oxononanoate synthase
HPY12_RS15905	ENOG4105CKI	cobalamin synthesis protein
HPY12_RS15910	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HPY12_RS15915	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HPY12_RS15920	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HPY12_RS15925	ENOG4105C08	Histidine kinase
HPY12_RS15930	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HPY12_RS15935	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HPY12_RS15940	ENOG4108RHM	integral membrane protein
HPY12_RS15950	ENOG4105EPM	Diguanylate phosphodiesterase
HPY12_RS15960	ENOG4105DS1	cytochrome b561
HPY12_RS15970	ENOG4105TMB	Formate nitrite transporter
HPY12_RS15975	ENOG4105DUM	transcriptional regulator, lysR family
HPY12_RS15980	ENOG4108UQ5	membrane protein YcdZ
HPY12_RS15985	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
HPY12_RS15990	ENOG4105CGH	5'-nucleotidase
HPY12_RS15995	ENOG4105DU1	integral membrane protein, terc
HPY12_RS16005	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HPY12_RS16035	ENOG4105BZU	Histidine kinase
HPY12_RS16045	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HPY12_RS16055	ENOG4105BZU	Histidine kinase
HPY12_RS16070	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY12_RS16075	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HPY12_RS16085	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY12_RS16105	ENOG4108RS6	transposase
HPY12_RS16165	ENOG4108ZJT	translation initiation factor, Sui1
HPY12_RS16185	ENOG4105CD5	CoA-binding domain protein
HPY12_RS16190	ENOG4105CWB	LysR family transcriptional Regulator
HPY12_RS16195	ENOG4105D05	Receptor
HPY12_RS16210	ENOG4105KA0	thioesterase Superfamily protein
HPY12_RS16230	ENOG4105CYM	Glutathione S-transferase
HPY12_RS16245	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HPY12_RS16250	ENOG4108JQ5	ABC transporter
HPY12_RS16255	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HPY12_RS16260	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HPY12_RS16265	ENOG4105E43	Extracellular solute-binding protein, family 5
HPY12_RS16290	ENOG4105DUX	Transporter
HPY12_RS16305	ENOG4107RCV	ABC transporter, permease
HPY12_RS16320	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HPY12_RS16325	ENOG4108JPW	Aminotransferase
HPY12_RS16330	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
HPY12_RS16335	ENOG4105NXH	GreA GreB family elongation factor
HPY12_RS16340	ENOG4105PAD	Hydrolase
HPY12_RS16350	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HPY12_RS16355	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HPY12_RS16360	ENOG4105CKU	formyltetrahydrofolate synthetase
HPY12_RS16365	ENOG4105E0X	reductase
HPY12_RS16370	ENOG4105EUJ	GTP cyclohydrolase i
HPY12_RS16375	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HPY12_RS16380	ENOG4105D06	uba thif-type nad fad binding protein
HPY12_RS16390	ENOG4105KHC	sulfurtransferase
HPY12_RS16405	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HPY12_RS16435	ENOG4108M3J	Dehydrogenase
HPY12_RS16450	ENOG4105RA2	Membrane
HPY12_RS16460	ENOG4105ETT	transcriptional Regulator, LysR family
HPY12_RS16465	ENOG41067V3	Antibiotic biosynthesis monooxygenase
HPY12_RS16470	ENOG4108RCM	Nitroreductase
HPY12_RS16490	ENOG4105MD1	YeeE YedE family protein
HPY12_RS16505	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HPY12_RS16550	ENOG4105C5Y	PTS System
HPY12_RS16555	ENOG4105ETE	Transcriptional regulator (LacI family
HPY12_RS16560	ENOG4107R3K	hydrolase
HPY12_RS16565	ENOG4105D7K	pfkb domain protein
HPY12_RS16570	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HPY12_RS16575	ENOG4108NVR	Methyl-accepting chemotaxis
HPY12_RS16585	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HPY12_RS16590	ENOG4107VXZ	Hydrolase
HPY12_RS16595	ENOG4108N3W	hemolysin secretion protein
HPY12_RS16600	ENOG4105CEE	C4-dicarboxylate transporter
HPY12_RS16605	ENOG4105EJQ	L-serine dehydratase
HPY12_RS16625	ENOG4105ETE	Transcriptional regulator (LacI family
HPY12_RS16630	ENOG4105WH1	Two component transcriptional regulator luxr family
HPY12_RS16635	ENOG4105BZU	Histidine kinase
HPY12_RS16650	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HPY12_RS16670	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY12_RS16675	ENOG4108KX4	response regulator
HPY12_RS16680	ENOG4105BZU	Histidine kinase
HPY12_RS16685	ENOG4105CXY	transporter
HPY12_RS16690	ENOG4105C4Y	ABC transporter
HPY12_RS16695	ENOG4107RCV	ABC transporter, permease
HPY12_RS16700	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS16705	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HPY12_RS16715	ENOG4105CHU	acetyl-coa acetyltransferase
HPY12_RS16725	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY12_RS16730	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HPY12_RS16745	ENOG4105BZU	Histidine kinase
HPY12_RS16750	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HPY12_RS16760	ENOG4108I6A	alcohol dehydrogenase
HPY12_RS16770	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
HPY12_RS16780	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
HPY12_RS16785	ENOG4105CXY	transporter
HPY12_RS16790	ENOG4105CA9	Pyruvate kinase
HPY12_RS16795	ENOG4105BZU	Histidine kinase
HPY12_RS16800	ENOG4108SV3	Tmao reductase system periplasmic protein tort
HPY12_RS16805	ENOG4108Z5K	methylglyoxal synthase
HPY12_RS16810	ENOG4108RWI	nicotinamidase
HPY12_RS16815	ENOG41080IJ	Diacylglycerol kinase
HPY12_RS16830	ENOG41088T4	Helicase IV
HPY12_RS16835	ENOG4105EM2	membrane
HPY12_RS16865	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS16870	ENOG4105E0C	molybdate abc transporter
HPY12_RS16875	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HPY12_RS16880	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HPY12_RS16885	ENOG4107UNZ	domain protein
HPY12_RS16920	ENOG4105BZU	Histidine kinase
HPY12_RS16925	ENOG4108QGH	periplasmic
HPY12_RS16935	ENOG41082IR	Excinuclease ABC C subunit domain protein
HPY12_RS16940	ENOG4108YXG	UPF0502 protein
HPY12_RS16950	ENOG41090HJ	UPF0265 protein
HPY12_RS16960	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HPY12_RS16965	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HPY12_RS16970	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HPY12_RS16980	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HPY12_RS16985	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HPY12_RS16990	ENOG4105K63	Thioredoxin
HPY12_RS17015	ENOG4105DMR	ABC, transporter
HPY12_RS17020	ENOG4105GBT	ABC transporter
HPY12_RS17025	ENOG4106PMH	Extracellular solute-binding protein family 3
HPY12_RS17030	ENOG4105E5Z	arginine transporter ATP-binding subunit
HPY12_RS17040	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
HPY12_RS17050	ENOG4108YZ4	nudix hydrolase
HPY12_RS17055	ENOG4105C5W	Aldolase
HPY12_RS17060	ENOG4106RE7	Cytochrome
HPY12_RS17065	ENOG4107XI7	Tetr family transcriptional regulator
HPY12_RS17070	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS17075	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
HPY12_RS17080	ENOG4105E0U	tyrosine-specific transport protein
HPY12_RS17085	ENOG4108N3W	hemolysin secretion protein
HPY12_RS17090	ENOG4105CMR	udp-glucose 4-epimerase
HPY12_RS17095	ENOG4105E7W	lamb ycsf family protein
HPY12_RS17105	ENOG4107R7A	Allophanate hydrolase subunit 2
HPY12_RS17115	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HPY12_RS17120	ENOG4105CV6	ABC transporter, permease
HPY12_RS17125	ENOG4108I0Y	(ABC) transporter
HPY12_RS17135	ENOG4105RKW	reductase (By
HPY12_RS17150	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HPY12_RS17165	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HPY12_RS17180	ENOG4107RE1	Inosine-guanosine kinase
HPY12_RS17185	ENOG4105E0M	Sulfatase
HPY12_RS17195	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS17210	ENOG4105CVA	phosphate
HPY12_RS17220	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HPY12_RS17230	ENOG4105D4Y	metalloprotease
HPY12_RS17240	ENOG4105CYW	agmatinase
HPY12_RS17245	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HPY12_RS17255	ENOG4105CJW	magnesium transporter
HPY12_RS17260	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HPY12_RS17265	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HPY12_RS17275	ENOG4105CZK	Aspartate kinase
HPY12_RS17280	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
HPY12_RS17285	ENOG4108JPW	Aminotransferase
HPY12_RS17290	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HPY12_RS17295	ENOG41090A4	Pterin carbinolamine dehydratase
HPY12_RS17300	ENOG4105MIR	Phenylalanine 4-monooxygenase
HPY12_RS17305	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HPY12_RS17320	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HPY12_RS17325	ENOG4105EGI	Transcriptional regulator
HPY12_RS17345	ENOG4105C37	(CBS) domain
HPY12_RS17350	ENOG4108UKZ	OsmC family
HPY12_RS17355	ENOG4107YWA	deoxycytidylate deaminase
HPY12_RS17380	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
HPY12_RS17385	ENOG4105DVH	amino acid
HPY12_RS17390	ENOG4106TD9	Diguanylate cyclase
HPY12_RS17400	ENOG4108VAC	response regulator
HPY12_RS17405	ENOG4108HRK	Histidine kinase
HPY12_RS17420	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HPY12_RS17425	ENOG4105C19	ABC transporter
HPY12_RS17435	ENOG4107RGM	aldo keto reductase
HPY12_RS17440	ENOG4107T9C	Alpha amylase catalytic region
HPY12_RS17450	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
HPY12_RS17455	ENOG4108M0H	Extracellular lipase
HPY12_RS17460	ENOG4107SDU	Methyl-accepting chemotaxis
HPY12_RS17465	ENOG4105D4Y	metalloprotease
HPY12_RS17470	ENOG4105EIF	outer membrane protein W
HPY12_RS17480	ENOG41061WM	D-Alanyl-D-Alanine
HPY12_RS17485	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HPY12_RS17490	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HPY12_RS17495	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HPY12_RS17510	ENOG4105BZC	d-serine deaminase
HPY12_RS17515	ENOG4105W8I	Transcriptional regulator
HPY12_RS17560	ENOG4105CPQ	Dehydrogenase
HPY12_RS17565	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HPY12_RS17580	ENOG4105EXG	Transcriptional regulator
HPY12_RS17585	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HPY12_RS17610	ENOG4105DHT	Metal Dependent Phosphohydrolase
HPY12_RS17615	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HPY12_RS17620	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
HPY12_RS17625	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HPY12_RS17650	ENOG4105BZW	Glycerate kinase
HPY12_RS17655	ENOG4105C6Z	Gluconate
HPY12_RS17665	ENOG4108NVR	Methyl-accepting chemotaxis
HPY12_RS17670	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
HPY12_RS17675	ENOG41090JE	Utilization Protein
HPY12_RS17680	ENOG4105D4P	Coproporphyrinogen iii oxidase
HPY12_RS17685	ENOG4105WQ5	TonB family
HPY12_RS17690	ENOG41090AP	transport protein
HPY12_RS17695	ENOG4106GFD	transport protein
HPY12_RS17700	ENOG4107R4I	Periplasmic binding protein
HPY12_RS17705	ENOG4105EHG	Permease protein
HPY12_RS17710	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HPY12_RS17740	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS17745	ENOG4105QVC	MOSC domain-containing protein
HPY12_RS17745	ENOG4105QVC	MOSC domain-containing protein
HPY12_RS17750	ENOG4105EKE	dihydroorotase
HPY12_RS17760	ENOG4105KAF	membrAne
HPY12_RS17770	ENOG4107SFS	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity)
HPY12_RS17775	ENOG4105CKW	Inner membrane protein yedI
HPY12_RS17780	ENOG4108ESY	Metal dependent phosphohydrolase
HPY12_RS17785	ENOG4105VEQ	Cold shock protein
HPY12_RS17810	ENOG4105BZU	Histidine kinase
HPY12_RS17815	ENOG4105E98	transcriptional regulator DeoR family
HPY12_RS17830	ENOG4105EG2	ABC transporter, permease
HPY12_RS17835	ENOG4105D56	permease protein
HPY12_RS17840	ENOG4107FKK	extracellular solute-binding protein family 1
HPY12_RS17845	ENOG4108IJ9	(ABC) transporter
HPY12_RS17865	ENOG4105K8R	UPF0145 protein
HPY12_RS17870	ENOG41086KC	Transcriptional regulator
HPY12_RS17875	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
HPY12_RS17885	ENOG4105RV9	Transcriptional regulator
HPY12_RS17890	ENOG4106TD9	Diguanylate cyclase
HPY12_RS17905	ENOG4105BZU	Histidine kinase
HPY12_RS17925	ENOG4105ETT	transcriptional Regulator, LysR family
HPY12_RS17930	ENOG4108K0B	C-di-gmp phosphodiesterase
HPY12_RS17940	ENOG4105EUB	pirin domain protein
HPY12_RS17945	ENOG4105NBK	UPF0345 protein
HPY12_RS17955	ENOG4105E5W	Transporter
HPY12_RS17960	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS17965	ENOG4105DAN	ATP-dependent protease
HPY12_RS17975	ENOG4108JQ5	ABC transporter
HPY12_RS17980	ENOG4105E89	ABC transporter
HPY12_RS17985	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS17995	ENOG4105CC0	LysR family Transcriptional regulator
HPY12_RS18005	ENOG4105DAA	L-lactate
HPY12_RS18020	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HPY12_RS18030	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HPY12_RS18040	ENOG4105C1J	atp-dependent rna helicase
HPY12_RS18045	ENOG4105CR8	Transcriptional regulator
HPY12_RS18055	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY12_RS18065	ENOG4105BZ1	(ABC) transporter
HPY12_RS18075	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HPY12_RS18085	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
HPY12_RS18110	ENOG4105K56	Transcriptional regulator
HPY12_RS18115	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HPY12_RS18125	ENOG4108SXK	Transporter Drug Metabolite Exporter family
HPY12_RS18130	ENOG4105VW4	glutaredoxin 3
HPY12_RS18135	ENOG4108P2H	Inner membrane protein YjiG
HPY12_RS18140	ENOG41074DU	domain protein
HPY12_RS18145	ENOG4105DN9	Na H antiporter
HPY12_RS18155	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HPY12_RS18160	ENOG4105D03	DNA-3-methyladenine glycosylase II
HPY12_RS18165	ENOG4108VGI	doxx family
HPY12_RS18190	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HPY12_RS18200	ENOG4107W52	maltose operon periplasmic protein
HPY12_RS18205	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
HPY12_RS18220	ENOG4108N3W	hemolysin secretion protein
HPY12_RS18235	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS18245	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HPY12_RS18250	ENOG4105CDA	abc transporter atp-binding protein
HPY12_RS18260	ENOG4106TNF	Periplasmic binding protein
HPY12_RS18265	ENOG4105EZ7	amino acid ABC transporter
HPY12_RS18270	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HPY12_RS18275	ENOG4105CTS	PTS system mannitol-specific
HPY12_RS18280	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HPY12_RS18285	ENOG4105E61	Mannitol repressor protein
HPY12_RS18290	ENOG4105EP9	oxidoreductase
HPY12_RS18330	ENOG4108W2Y	isochorismatase
HPY12_RS18335	ENOG41063TF	transcriptional regulator (AraC
HPY12_RS18340	ENOG4108RYK	Nad-dependent epimerase dehydratase
HPY12_RS18345	ENOG4105JQN	Transcriptional regulator
HPY12_RS18350	ENOG41069D7	Methyl-accepting chemotaxis
HPY12_RS18355	ENOG4105EMU	Dehydrogenase
HPY12_RS18360	ENOG4105JQN	Transcriptional regulator
HPY12_RS18375	ENOG4105D5Q	Arginine ornithine antiporter
HPY12_RS18380	ENOG4105CXN	decarboxylase
HPY12_RS18390	ENOG4107RGH	Aldehyde dehydrogenase
HPY12_RS18395	ENOG4105EW9	transcriptional regulator AsnC family
HPY12_RS18400	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS18410	ENOG4105CK7	Sodium proline symporter
HPY12_RS18420	ENOG4105C26	Dehydrogenase
HPY12_RS18435	ENOG4105E6M	Sulphatase-modifying factor protein
HPY12_RS18450	ENOG4107QZV	Type I secretion membrane fusion protein
HPY12_RS18465	ENOG4108JJA	ABC, transporter
HPY12_RS18475	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HPY12_RS18485	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS18490	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HPY12_RS18500	ENOG4105BZU	Histidine kinase
HPY12_RS18505	ENOG4105C8Q	Methyl-accepting chemotaxis
HPY12_RS18510	ENOG4108V3W	Chemotaxis protein, CheW
HPY12_RS18515	ENOG4108V3W	Chemotaxis protein, CheW
HPY12_RS18520	ENOG4105CBS	Chea signal transduction histidine kinase
HPY12_RS18525	ENOG4108VYJ	response regulator receiver protein
HPY12_RS18540	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS18545	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HPY12_RS18550	ENOG4108JQ6	ABC transporter
HPY12_RS18555	ENOG4105DIJ	Phosphoethanolamine transferase
HPY12_RS18560	ENOG4105DHQ	Histidine kinase
HPY12_RS18565	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HPY12_RS18595	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
HPY12_RS18600	ENOG4107RUE	extracellular solute-binding protein family 1