locus-tag	class	description
HPY09_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPY09_RS00010	COG0592	DNA-directed DNA polymerase activity
HPY09_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPY09_RS00020	COG0187	DNA topoisomerase II activity
HPY09_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
HPY09_RS00035	COG3977	Valine--pyruvate aminotransferase
HPY09_RS00040	COG0751	glycine-tRNA ligase activity
HPY09_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
HPY09_RS00050	COG2119	membrane
HPY09_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
HPY09_RS00070	COG0604	alcohol dehydrogenase
HPY09_RS00080	COG0129	dihydroxy-acid dehydratase activity
HPY09_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY09_RS00100	COG0606	chelatase, subunit chli
HPY09_RS00105	COG0204	Acyl-transferase
HPY09_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY09_RS00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPY09_RS00125	COG3084	Protein conserved in bacteria
HPY09_RS00135	COG4326	sporulation control protein
HPY09_RS00140	COG1272	protein, Hemolysin III
HPY09_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY09_RS00155	COG0569	domain protein
HPY09_RS00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY09_RS00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPY09_RS00170	COG0242	peptide deformylase activity
HPY09_RS00175	COG1652	LysM domain
HPY09_RS00180	COG0758	DNA mediated transformation
HPY09_RS00185	COG2922	Belongs to the Smg family
HPY09_RS00190	COG0551	DNA topoisomerase type I activity
HPY09_RS00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPY09_RS00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPY09_RS00205	COG0009	L-threonylcarbamoyladenylate synthase
HPY09_RS00210	COG0408	coproporphyrinogen oxidase activity
HPY09_RS00215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPY09_RS00225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPY09_RS00260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPY09_RS00265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPY09_RS00275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY09_RS00280	COG2104	thiamine diphosphate biosynthetic process
HPY09_RS00285	COG2022	thiamine diphosphate biosynthetic process
HPY09_RS00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY09_RS00295	COG0006	proline dipeptidase activity
HPY09_RS00295	COG0006	proline dipeptidase activity
HPY09_RS00315	COG1522	sequence-specific DNA binding
HPY09_RS00320	COG5001	Diguanylate cyclase
HPY09_RS00320	COG5002	protein histidine kinase activity
HPY09_RS00340	COG0589	response to stress
HPY09_RS00345	COG1528	Iron-storage protein
HPY09_RS00355	COG2081	HI0933 family
HPY09_RS00365	COG1322	Protein conserved in bacteria
HPY09_RS00370	COG2226	methyltransferase
HPY09_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY09_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY09_RS00395	COG0805	protein transport
HPY09_RS00400	COG1858	cytochrome C peroxidase
HPY09_RS00405	COG0534	Mate efflux family protein
HPY09_RS00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY09_RS00420	COG2937	Belongs to the GPAT DAPAT family
HPY09_RS00425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPY09_RS00430	COG3161	chorismate lyase activity
HPY09_RS00435	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY09_RS00440	COG0840	transmembrane signaling receptor activity
HPY09_RS00450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY09_RS00455	COG0084	hydrolase, TatD family'
HPY09_RS00470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY09_RS00470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY09_RS00490	COG3078	GTPase activator activity
HPY09_RS00505	COG3071	HemY protein
HPY09_RS00510	COG2959	enzyme of heme biosynthesis
HPY09_RS00515	COG1587	Uroporphyrinogen-III synthase
HPY09_RS00520	COG0181	hydroxymethylbilane synthase activity
HPY09_RS00530	COG1965	Belongs to the frataxin family
HPY09_RS00540	COG0019	diaminopimelate decarboxylase activity
HPY09_RS00545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPY09_RS00555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPY09_RS00560	COG1011	Hydrolase
HPY09_RS00565	COG3287	FIST C domain
HPY09_RS00565	COG2200	EAL domain
HPY09_RS00565	COG2199	diguanylate cyclase activity
HPY09_RS00580	COG0561	phosphatase activity
HPY09_RS00585	COG2267	carboxylic ester hydrolase activity
HPY09_RS00590	COG1280	lysine exporter protein (LysE YggA)
HPY09_RS00595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY09_RS00600	COG0783	Belongs to the Dps family
HPY09_RS00630	COG0742	ribosomal rna small subunit methyltransferase
HPY09_RS00635	COG0552	protein localization to endoplasmic reticulum
HPY09_RS00640	COG2884	Cell division ATP-binding protein ftsE
HPY09_RS00645	COG2177	Part of the ABC transporter FtsEX involved in
HPY09_RS00650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY09_RS00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY09_RS00680	COG1404	Belongs to the peptidase S8 family
HPY09_RS00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPY09_RS00750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HPY09_RS00755	COG5001	Diguanylate cyclase
HPY09_RS00755	COG3300	MHYT domain
HPY09_RS00765	COG3852	Histidine kinase
HPY09_RS00775	COG0174	glutamine synthetase
HPY09_RS00795	COG1295	ribonuclease BN
HPY09_RS00800	COG1490	D-aminoacyl-tRNA deacylase activity
HPY09_RS00805	COG0456	acetyltransferase
HPY09_RS00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HPY09_RS00820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPY09_RS00825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPY09_RS00830	COG3031	protein transport across the cell outer membrane
HPY09_RS00840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY09_RS00845	COG1459	type II secretion system
HPY09_RS00850	COG2165	general secretion pathway protein
HPY09_RS00855	COG2165	general secretion pathway protein
HPY09_RS00860	COG2165	general secretion pathway protein
HPY09_RS00865	COG4795	General secretion pathway protein
HPY09_RS00870	COG3156	type II secretion system protein K
HPY09_RS00875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY09_RS00880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPY09_RS00890	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPY09_RS00895	COG0494	nUDIX hydrolase
HPY09_RS00905	COG1040	competence protein
HPY09_RS00915	COG0596	Alpha beta hydrolase
HPY09_RS00925	COG2183	response to ionizing radiation
HPY09_RS00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY09_RS00935	COG2199	diguanylate cyclase activity
HPY09_RS00940	COG0745	RESPONSE REGULATOR receiver
HPY09_RS00950	COG2233	PERMEase
HPY09_RS00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPY09_RS00960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY09_RS00965	COG1758	RNA polymerase activity
HPY09_RS00970	COG0194	GDP metabolic process
HPY09_RS00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPY09_RS00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY09_RS01000	COG4232	protein-disulfide reductase activity
HPY09_RS01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY09_RS01015	COG1027	Aspartate ammonia-lyase
HPY09_RS01020	COG3706	GGDEF domain
HPY09_RS01025	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPY09_RS01030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPY09_RS01040	COG2205	protein histidine kinase activity
HPY09_RS01045	COG0745	RESPONSE REGULATOR receiver
HPY09_RS01055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPY09_RS01060	COG0205	6-phosphofructokinase activity
HPY09_RS01065	COG1494	fructose-1,6-bisphosphatase
HPY09_RS01070	COG3074	FtsZ-dependent cytokinesis
HPY09_RS01075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPY09_RS01080	COG0460	homoserine dehydrogenase
HPY09_RS01080	COG0527	aspartate kinase activity
HPY09_RS01090	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HPY09_RS01095	COG0281	malic enzyme
HPY09_RS01100	COG0254	rRNA binding
HPY09_RS01105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPY09_RS01110	COG1609	Transcriptional regulator
HPY09_RS01115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY09_RS01120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPY09_RS01125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPY09_RS01130	COG1575	Belongs to the MenA family. Type 1 subfamily
HPY09_RS01135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY09_RS01140	COG0534	Mate efflux family protein
HPY09_RS01145	COG0149	triose-phosphate isomerase activity
HPY09_RS01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY09_RS01175	COG0459	protein refolding
HPY09_RS01185	COG1509	lysine 2,3-aminomutase activity
HPY09_RS01190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY09_RS01200	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HPY09_RS01205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPY09_RS01210	COG1053	succinate dehydrogenase
HPY09_RS01215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPY09_RS01220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY09_RS01225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPY09_RS01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPY09_RS01235	COG1045	serine acetyltransferase
HPY09_RS01245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPY09_RS01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPY09_RS01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPY09_RS01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY09_RS01265	COG0137	argininosuccinate synthase activity
HPY09_RS01270	COG0165	Argininosuccinate lyase
HPY09_RS01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_RS01285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY09_RS01285	COG0678	peroxiredoxin activity
HPY09_RS01295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPY09_RS01325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPY09_RS01330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPY09_RS01340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPY09_RS01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPY09_RS01350	COG0546	phosphoglycolate phosphatase activity
HPY09_RS01355	COG0180	Tryptophanyl-tRNA synthetase
HPY09_RS01375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY09_RS01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPY09_RS01395	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_RS01410	COG3954	Phosphoribulokinase
HPY09_RS01420	COG0429	hydrolase of the alpha beta-hydrolase fold
HPY09_RS01430	COG0488	(ABC) transporter
HPY09_RS01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPY09_RS01450	COG1047	Peptidyl-prolyl cis-trans
HPY09_RS01460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY09_RS01465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPY09_RS01475	COG0557	exoribonuclease II activity
HPY09_RS01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY09_RS01485	COG0051	transcription antitermination factor activity, RNA binding
HPY09_RS01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPY09_RS01495	COG0088	Forms part of the polypeptide exit tunnel
HPY09_RS01500	COG0089	rRNA binding
HPY09_RS01505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPY09_RS01510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPY09_RS01515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPY09_RS01520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPY09_RS01525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPY09_RS01530	COG0255	Belongs to the universal ribosomal protein uL29 family
HPY09_RS01535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPY09_RS01540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPY09_RS01545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPY09_RS01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPY09_RS01555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPY09_RS01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPY09_RS01565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPY09_RS01570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPY09_RS01575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPY09_RS01580	COG1841	ribosomal large subunit assembly
HPY09_RS01590	COG0201	protein transport
HPY09_RS01595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY09_RS01600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPY09_RS01605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPY09_RS01610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPY09_RS01615	COG0202	RNA polymerase activity
HPY09_RS01620	COG0203	ribosomal protein L17
HPY09_RS01630	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY09_RS01635	COG3266	domain, Protein
HPY09_RS01635	COG3061	Opacity-associated protein A
HPY09_RS01640	COG0697	spore germination
HPY09_RS01645	COG2153	protein acetylation
HPY09_RS01650	COG0513	Belongs to the DEAD box helicase family
HPY09_RS01660	COG0737	Belongs to the 5'-nucleotidase family
HPY09_RS01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPY09_RS01665	COG1648	precorrin-2 dehydrogenase activity
HPY09_RS01670	COG0175	sulfate reduction
HPY09_RS01675	COG2895	sulfate adenylyltransferase (ATP) activity
HPY09_RS01680	COG0529	Catalyzes the synthesis of activated sulfate
HPY09_RS01700	COG1136	(ABC) transporter
HPY09_RS01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPY09_RS01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_RS01725	COG0729	surface antigen
HPY09_RS01735	COG2105	PFAM AIG2 family protein
HPY09_RS01740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPY09_RS01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY09_RS01755	COG0163	prenyltransferase activity
HPY09_RS01765	COG1178	ABC-type Fe3 transport system permease component
HPY09_RS01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HPY09_RS01775	COG3028	Belongs to the UPF0307 family
HPY09_RS01780	COG0312	modulator of DNA gyrase
HPY09_RS01785	COG2239	Acts as a magnesium transporter
HPY09_RS01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_RS01795	COG1660	Displays ATPase and GTPase activities
HPY09_RS01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_RS01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY09_RS01815	COG1137	ATPase activity
HPY09_RS01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPY09_RS01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY09_RS01835	COG0517	IMP dehydrogenase activity
HPY09_RS01845	COG1127	ABC transporter
HPY09_RS01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPY09_RS01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY09_RS01860	COG2854	intermembrane phospholipid transfer
HPY09_RS01870	COG5007	Belongs to the BolA IbaG family
HPY09_RS01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPY09_RS01885	COG0251	oxidation-reduction process
HPY09_RS01895	COG0540	Belongs to the ATCase OTCase family
HPY09_RS01905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPY09_RS01920	COG0564	pseudouridine synthase activity
HPY09_RS01925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY09_RS01930	COG0525	valine-tRNA ligase activity
HPY09_RS01935	COG2927	DNA polymerase III (CHI subunit)
HPY09_RS01940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPY09_RS01945	COG0795	lipopolysaccharide-transporting ATPase activity
HPY09_RS01950	COG0795	lipopolysaccharide-transporting ATPase activity
HPY09_RS01965	COG3437	response regulator, receiver
HPY09_RS02005	COG0066	3-isopropylmalate dehydratase activity
HPY09_RS02010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPY09_RS02015	COG0473	3-isopropylmalate dehydrogenase activity
HPY09_RS02045	COG1022	Amp-dependent synthetase and ligase
HPY09_RS02050	COG0028	Belongs to the TPP enzyme family
HPY09_RS02055	COG0440	acetolactate synthase activity
HPY09_RS02060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY09_RS02065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPY09_RS02070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPY09_RS02080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPY09_RS02085	COG3079	Belongs to the UPF0149 family
HPY09_RS02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_RS02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_RS02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPY09_RS02120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPY09_RS02125	COG1595	DNA-templated transcription, initiation
HPY09_RS02140	COG3086	response to oxidative stress
HPY09_RS02145	COG0481	GTPase activity
HPY09_RS02155	COG0571	ribonuclease III activity
HPY09_RS02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPY09_RS02165	COG1381	Involved in DNA repair and RecF pathway recombination
HPY09_RS02170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPY09_RS02175	COG0736	holo-[acyl-carrier-protein] synthase activity
HPY09_RS02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPY09_RS02210	COG3956	TIGRFAM MazG family protein
HPY09_RS02215	COG0504	CTP synthase activity
HPY09_RS02220	COG0148	phosphopyruvate hydratase activity
HPY09_RS02225	COG0617	tRNA 3'-terminal CCA addition
HPY09_RS02230	COG3409	Peptidoglycan-binding domain 1 protein
HPY09_RS02230	COG3267	Type II secretory pathway component ExeA
HPY09_RS02240	COG4991	sh3 domain protein
HPY09_RS02245	COG0306	phosphate transporter
HPY09_RS02250	COG1392	Phosphate transport regulator
HPY09_RS02255	COG3025	triphosphatase activity
HPY09_RS02260	COG0840	transmembrane signaling receptor activity
HPY09_RS02265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPY09_RS02275	COG1538	Outer membrane efflux protein
HPY09_RS02280	COG0494	nUDIX hydrolase
HPY09_RS02285	COG3151	Protein conserved in bacteria
HPY09_RS02295	COG3150	esterase
HPY09_RS02300	COG0187	DNA topoisomerase II activity
HPY09_RS02305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPY09_RS02315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPY09_RS02320	COG0237	dephospho-CoA kinase activity
HPY09_RS02330	COG1459	type II secretion system
HPY09_RS02335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY09_RS02355	COG0716	FMN binding
HPY09_RS02360	COG4974	Belongs to the 'phage' integrase family
HPY09_RS02365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY09_RS02370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPY09_RS02375	COG2186	Transcriptional regulator
HPY09_RS02380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPY09_RS02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY09_RS02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_RS02405	COG3116	cell division
HPY09_RS02410	COG0768	penicillin binding
HPY09_RS02415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPY09_RS02420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPY09_RS02430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPY09_RS02435	COG0772	Belongs to the SEDS family
HPY09_RS02440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPY09_RS02445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPY09_RS02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPY09_RS02455	COG0849	cell division
HPY09_RS02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPY09_RS02465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPY09_RS02475	COG0653	protein targeting
HPY09_RS02480	COG0494	nUDIX hydrolase
HPY09_RS02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPY09_RS02495	COG0505	Belongs to the CarA family
HPY09_RS02500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPY09_RS02520	COG0730	response to heat
HPY09_RS02525	COG0583	DNA-binding transcription factor activity
HPY09_RS02530	COG2860	membrane
HPY09_RS02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPY09_RS02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPY09_RS02555	COG0493	'glutamate synthase
HPY09_RS02560	COG0067	glutamate synthase
HPY09_RS02560	COG0069	glutamate synthase activity
HPY09_RS02560	COG0070	glutamate synthase
HPY09_RS02570	COG0069	glutamate synthase activity
HPY09_RS02570	COG0070	glutamate synthase
HPY09_RS02570	COG0067	glutamate synthase
HPY09_RS02580	COG2203	Gaf domain
HPY09_RS02580	COG4251	negative regulation of phosphorylation
HPY09_RS02580	COG3706	GGDEF domain
HPY09_RS02580	COG5001	Diguanylate cyclase
HPY09_RS02585	COG0784	Response regulator, receiver
HPY09_RS02585	COG2198	Histidine kinase
HPY09_RS02585	COG5002	protein histidine kinase activity
HPY09_RS02590	COG0745	RESPONSE REGULATOR receiver
HPY09_RS02600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPY09_RS02620	COG0083	homoserine kinase activity
HPY09_RS02625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPY09_RS02630	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HPY09_RS02635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HPY09_RS02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPY09_RS02655	COG1115	amino acid carrier protein
HPY09_RS02660	COG3022	response to hydroperoxide
HPY09_RS02670	COG0084	hydrolase, TatD family'
HPY09_RS02675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY09_RS02685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPY09_RS02690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPY09_RS02695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPY09_RS02700	COG0813	purine-nucleoside phosphorylase activity
HPY09_RS02710	COG0560	Phosphoserine phosphatase
HPY09_RS02720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPY09_RS02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY09_RS02730	COG1022	Amp-dependent synthetase and ligase
HPY09_RS02745	COG3250	beta-galactosidase activity
HPY09_RS02750	COG1609	Transcriptional regulator
HPY09_RS02755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_RS02770	COG0189	ligase activity
HPY09_RS02770	COG0569	domain protein
HPY09_RS02775	COG0456	acetyltransferase
HPY09_RS02785	COG2171	N-acyltransferase activity
HPY09_RS02790	COG3141	response to X-ray
HPY09_RS02805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPY09_RS02810	COG1074	ATP-dependent DNA helicase activity
HPY09_RS02815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPY09_RS02825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPY09_RS02825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPY09_RS02835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPY09_RS02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPY09_RS02845	COG2166	iron-sulfur cluster assembly
HPY09_RS02850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY09_RS02855	COG0693	protein deglycase activity
HPY09_RS02860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPY09_RS02865	COG3248	Nucleoside-binding outer membrane protein
HPY09_RS02875	COG1595	DNA-templated transcription, initiation
HPY09_RS02885	COG2211	Major facilitator Superfamily
HPY09_RS02890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY09_RS02900	COG2813	Specifically methylates the guanine in position
HPY09_RS02905	COG0271	Belongs to the BolA IbaG family
HPY09_RS02910	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY09_RS02915	COG1805	sodium ion transport
HPY09_RS02920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY09_RS02930	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPY09_RS02935	COG2871	sodium ion transport
HPY09_RS02940	COG1477	protein flavinylation
HPY09_RS02960	COG3706	GGDEF domain
HPY09_RS02965	COG0733	neurotransmitter:sodium symporter activity
HPY09_RS02970	COG3385	transposase activity
HPY09_RS02980	COG0189	ligase activity
HPY09_RS02985	COG4067	protein conserved in archaea
HPY09_RS02985	COG0189	ligase activity
HPY09_RS02990	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY09_RS02995	COG2252	PERMEase
HPY09_RS03000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPY09_RS03015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPY09_RS03020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPY09_RS03025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPY09_RS03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_RS03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_RS03045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPY09_RS03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPY09_RS03055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPY09_RS03060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPY09_RS03070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPY09_RS03075	COG0024	Methionine aminopeptidase
HPY09_RS03080	COG0052	Belongs to the universal ribosomal protein uS2 family
HPY09_RS03085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPY09_RS03090	COG0528	UMP kinase activity
HPY09_RS03095	COG0233	cytoplasmic translational termination
HPY09_RS03100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPY09_RS03105	COG0575	Belongs to the CDS family
HPY09_RS03110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPY09_RS03115	COG0750	zinc metalloprotease
HPY09_RS03125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPY09_RS03130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_RS03135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY09_RS03140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_RS03145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_RS03150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPY09_RS03155	COG0587	DNA-directed DNA polymerase activity
HPY09_RS03160	COG0825	malonyl-CoA metabolic process
HPY09_RS03165	COG0037	tRNA processing
HPY09_RS03175	COG3479	Phenolic acid decarboxylase
HPY09_RS03180	COG0347	Belongs to the P(II) protein family
HPY09_RS03185	COG3021	interspecies interaction between organisms
HPY09_RS03190	COG0741	lytic transglycosylase activity
HPY09_RS03190	COG1388	LysM domain
HPY09_RS03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY09_RS03200	COG2226	methyltransferase
HPY09_RS03205	COG0328	RNA-DNA hybrid ribonuclease activity
HPY09_RS03220	COG1960	acyl-CoA dehydrogenase activity
HPY09_RS03225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY09_RS03230	COG0121	glutamine amidotransferase
HPY09_RS03235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPY09_RS03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPY09_RS03245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPY09_RS03250	COG3706	GGDEF domain
HPY09_RS03255	COG1187	pseudouridine synthase activity
HPY09_RS03260	COG2840	Smr protein MutS2
HPY09_RS03290	COG2217	Heavy metal translocating P-type atpase
HPY09_RS03290	COG2608	mercury ion transmembrane transporter activity
HPY09_RS03295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY09_RS03310	COG4774	siderophore transport
HPY09_RS03310	COG1629	transport
HPY09_RS03315	COG2375	cellular response to nickel ion
HPY09_RS03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY09_RS03320	COG3433	isochorismatase activity
HPY09_RS03320	COG2226	methyltransferase
HPY09_RS03355	COG0835	chemotaxis
HPY09_RS03355	COG0784	Response regulator, receiver
HPY09_RS03360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY09_RS03365	COG1815	bacterial-type flagellum-dependent cell motility
HPY09_RS03380	COG1749	Flagellar hook protein flgE
HPY09_RS03385	COG4787	bacterial-type flagellum-dependent cell motility
HPY09_RS03395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HPY09_RS03400	COG1706	bacterial-type flagellum-dependent cell motility
HPY09_RS03405	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPY09_RS03405	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPY09_RS03420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_RS03425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_RS03510	COG0012	GTP binding
HPY09_RS03515	COG0193	aminoacyl-tRNA hydrolase activity
HPY09_RS03520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPY09_RS03525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPY09_RS03530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HPY09_RS03535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPY09_RS03540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPY09_RS03545	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY09_RS03555	COG2912	Transglutaminase-like superfamily
HPY09_RS03560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY09_RS03565	COG0737	Belongs to the 5'-nucleotidase family
HPY09_RS03570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPY09_RS03575	COG2233	PERMEase
HPY09_RS03595	COG1393	Belongs to the ArsC family
HPY09_RS03600	COG4783	chaperone-mediated protein folding
HPY09_RS03620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPY09_RS03635	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPY09_RS03645	COG1876	peptidase activity
HPY09_RS03655	COG1393	Belongs to the ArsC family
HPY09_RS03675	COG2837	iron assimilation
HPY09_RS03680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_RS03685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_RS03690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPY09_RS03695	COG1334	flagellar protein FlaG
HPY09_RS03700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPY09_RS03710	COG1516	flagellar protein fliS
HPY09_RS03720	COG4191	Histidine kinase
HPY09_RS03730	COG1677	Flagellar hook-basal body complex protein FliE
HPY09_RS03740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPY09_RS03745	COG1317	bacterial-type flagellum organization
HPY09_RS03770	COG1580	Controls the rotational direction of flagella during chemotaxis
HPY09_RS03795	COG1987	bacterial-type flagellum assembly
HPY09_RS03800	COG1684	flagellar biosynthetic protein fliR
HPY09_RS03810	COG2840	Smr protein MutS2
HPY09_RS03815	COG2890	protein-(glutamine-N5) methyltransferase activity
HPY09_RS03820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPY09_RS03825	COG2860	membrane
HPY09_RS03830	COG3101	peptidyl-lysine hydroxylation
HPY09_RS03840	COG0431	NADPH-dependent FMN reductase
HPY09_RS03845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPY09_RS03845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPY09_RS03850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY09_RS03855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY09_RS03860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY09_RS03865	COG0735	belongs to the Fur family
HPY09_RS03875	COG0583	DNA-binding transcription factor activity
HPY09_RS03885	COG1346	cytolysis
HPY09_RS03900	COG0596	Alpha beta hydrolase
HPY09_RS03905	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPY09_RS03910	COG0033	Phosphoglucomutase
HPY09_RS03920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPY09_RS03925	COG0372	Belongs to the citrate synthase family
HPY09_RS03930	COG2009	succinate dehydrogenase
HPY09_RS03935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPY09_RS03940	COG1053	succinate dehydrogenase
HPY09_RS03950	COG0567	Dehydrogenase, E1 component
HPY09_RS03955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPY09_RS03960	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY09_RS03970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPY09_RS03975	COG1121	(ABC) transporter
HPY09_RS03980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPY09_RS03985	COG4977	sequence-specific DNA binding
HPY09_RS03990	COG1918	ferrous iron import across plasma membrane
HPY09_RS04010	COG0018	arginyl-trna synthetase
HPY09_RS04020	COG1025	Belongs to the peptidase M16 family
HPY09_RS04025	COG2062	phosphohistidine phosphatase, SixA
HPY09_RS04055	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPY09_RS04060	COG0643	Histidine kinase
HPY09_RS04060	COG0784	Response regulator, receiver
HPY09_RS04060	COG2198	Histidine kinase
HPY09_RS04065	COG2201	protein-glutamate methylesterase activity
HPY09_RS04070	COG1192	Involved in chromosome partitioning
HPY09_RS04080	COG0835	chemotaxis
HPY09_RS04090	COG4133	protoheme IX ABC transporter activity
HPY09_RS04095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY09_RS04100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPY09_RS04110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPY09_RS04115	COG1138	Cytochrome C-type biogenesis protein
HPY09_RS04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPY09_RS04125	COG4235	cytochrome complex assembly
HPY09_RS04125	COG3088	subunit of a heme lyase
HPY09_RS04135	COG2853	Lipoprotein
HPY09_RS04155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPY09_RS04160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY09_RS04165	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPY09_RS04180	COG3083	sulfuric ester hydrolase activity
HPY09_RS04185	COG3082	Protein of unknown function (DUF1414)
HPY09_RS04190	COG3081	Nucleoid-associated protein
HPY09_RS04200	COG1757	Na H antiporter
HPY09_RS04205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPY09_RS04210	COG2095	MarC family integral membrane protein
HPY09_RS04215	COG1454	alcohol dehydrogenase
HPY09_RS04215	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_RS04225	COG0659	secondary active sulfate transmembrane transporter activity
HPY09_RS04230	COG1530	ribonuclease E activity
HPY09_RS04235	COG0564	pseudouridine synthase activity
HPY09_RS04240	COG0424	maF-like protein
HPY09_RS04245	COG1399	metal-binding, possibly nucleic acid-binding protein
HPY09_RS04250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPY09_RS04255	COG0416	fatty acid biosynthetic process
HPY09_RS04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY09_RS04270	COG1028	Short-chain dehydrogenase reductase Sdr
HPY09_RS04275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPY09_RS04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY09_RS04285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPY09_RS04290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPY09_RS04295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPY09_RS04305	COG0084	hydrolase, TatD family'
HPY09_RS04310	COG1263	PTS System
HPY09_RS04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_RS04320	COG0733	neurotransmitter:sodium symporter activity
HPY09_RS04345	COG1940	carbohydrate kinase activity
HPY09_RS04350	COG0835	chemotaxis
HPY09_RS04350	COG0784	Response regulator, receiver
HPY09_RS04365	COG2226	methyltransferase
HPY09_RS04375	COG0676	glucose-6-phosphate 1-epimerase activity
HPY09_RS04380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY09_RS04385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_RS04395	COG3139	Protein of unknown function (DUF1315)
HPY09_RS04400	COG0252	asparaginase activity
HPY09_RS04405	COG0616	signal peptide processing
HPY09_RS04410	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY09_RS04410	COG1902	pentaerythritol trinitrate reductase activity
HPY09_RS04415	COG0788	formyltetrahydrofolate deformylase activity
HPY09_RS04425	COG1199	ATP-dependent helicase activity
HPY09_RS04430	COG1214	PFAM Peptidase M22, glycoprotease
HPY09_RS04445	COG0596	Alpha beta hydrolase
HPY09_RS04450	COG0318	PFAM AMP-dependent synthetase and ligase
HPY09_RS04455	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPY09_RS04475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY09_RS04480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPY09_RS04485	COG0436	Aminotransferase
HPY09_RS04490	COG1169	isochorismate synthase
HPY09_RS04495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPY09_RS04500	COG0596	Alpha beta hydrolase
HPY09_RS04520	COG3135	benzoate transporter
HPY09_RS04545	COG3015	lipoprotein NlpE involved in copper resistance
HPY09_RS04550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPY09_RS04555	COG2894	cell division
HPY09_RS04560	COG0850	regulation of cytokinetic process
HPY09_RS04565	COG3100	YcgL domain-containing protein
HPY09_RS04570	COG2951	lytic endotransglycosylase activity
HPY09_RS04580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY09_RS04585	COG3005	denitrification pathway
HPY09_RS04590	COG0243	molybdopterin cofactor binding
HPY09_RS04605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_RS04620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPY09_RS04655	COG4589	Belongs to the CDS family
HPY09_RS04665	COG5001	Diguanylate cyclase
HPY09_RS04665	COG3300	MHYT domain
HPY09_RS04675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPY09_RS04680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPY09_RS04685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPY09_RS04690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPY09_RS04700	COG4191	Histidine kinase
HPY09_RS04710	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPY09_RS04720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPY09_RS04725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPY09_RS04730	COG0776	regulation of translation
HPY09_RS04735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY09_RS04740	COG1555	photosystem II stabilization
HPY09_RS04745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPY09_RS04750	COG0539	negative regulation of cytoplasmic translation
HPY09_RS04755	COG0776	regulation of translation
HPY09_RS04760	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPY09_RS04765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPY09_RS04785	COG0583	DNA-binding transcription factor activity
HPY09_RS04795	COG0686	Belongs to the AlaDH PNT family
HPY09_RS04805	COG1674	ftsk spoiiie
HPY09_RS04810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPY09_RS04815	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY09_RS04820	COG2186	Transcriptional regulator
HPY09_RS04835	COG0537	adenosine 5'-monophosphoramidase activity
HPY09_RS04860	COG3150	esterase
HPY09_RS04865	COG1252	NADH dehydrogenase
HPY09_RS04890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPY09_RS04900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY09_RS04905	COG1136	(ABC) transporter
HPY09_RS04910	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY09_RS04920	COG2333	competence protein COMEC
HPY09_RS04920	COG0658	competence protein
HPY09_RS04925	COG1132	(ABC) transporter
HPY09_RS04930	COG1663	tetraacyldisaccharide 4'-kinase activity
HPY09_RS04935	COG2835	tetraacyldisaccharide 4'-kinase activity
HPY09_RS04940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY09_RS04945	COG2719	SpoVR family
HPY09_RS04950	COG2718	Belongs to the UPF0229 family
HPY09_RS04955	COG2766	serine protein kinase
HPY09_RS04960	COG3385	transposase activity
HPY09_RS04965	COG3013	Belongs to the UPF0304 family
HPY09_RS04975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPY09_RS04980	COG0840	transmembrane signaling receptor activity
HPY09_RS04990	COG1882	Formate acetyltransferase
HPY09_RS05015	COG4160	amino acid transport
HPY09_RS05020	COG0708	Exodeoxyribonuclease III
HPY09_RS05030	COG3923	Primosomal replication protein n
HPY09_RS05035	COG0730	response to heat
HPY09_RS05040	COG1199	ATP-dependent helicase activity
HPY09_RS05050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY09_RS05055	COG3012	SEC-C Motif Domain Protein
HPY09_RS05060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPY09_RS05065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPY09_RS05070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPY09_RS05075	COG0215	cysteine-tRNA ligase activity
HPY09_RS05080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPY09_RS05085	COG0632	four-way junction helicase activity
HPY09_RS05095	COG1271	oxidase subunit
HPY09_RS05100	COG1294	oxidase, subunit
HPY09_RS05105	COG4890	Cyd operon protein YbgT
HPY09_RS05110	COG3790	cyd operon protein YbgE
HPY09_RS05115	COG0824	Thioesterase
HPY09_RS05120	COG0811	peptide transport
HPY09_RS05135	COG0823	Involved in the tonB-independent uptake of proteins
HPY09_RS05140	COG2885	chlorophyll binding
HPY09_RS05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPY09_RS05160	COG0784	Response regulator, receiver
HPY09_RS05160	COG5002	protein histidine kinase activity
HPY09_RS05170	COG1482	cell wall glycoprotein biosynthetic process
HPY09_RS05175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_RS05175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_RS05175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_RS05180	COG2207	Transcriptional regulator
HPY09_RS05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_RS05200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_RS05210	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_RS05215	COG3284	Transcriptional regulator
HPY09_RS05220	COG4628	conserved protein (DUF2132)
HPY09_RS05230	COG0415	Belongs to the DNA photolyase family
HPY09_RS05315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPY09_RS05325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPY09_RS05365	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HPY09_RS05410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPY09_RS05425	COG0681	Belongs to the peptidase S26 family
HPY09_RS05470	COG3064	Membrane
HPY09_RS05500	COG2351	hydroxyisourate hydrolase activity
HPY09_RS05515	COG5492	domain, Protein
HPY09_RS05515	COG4932	domain protein
HPY09_RS05540	COG4796	Type ii and iii secretion system protein
HPY09_RS05565	COG1459	type II secretion system
HPY09_RS05585	COG2207	Transcriptional regulator
HPY09_RS05630	COG3710	Transcriptional regulator
HPY09_RS05635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY09_RS05680	COG0629	single-stranded DNA binding
HPY09_RS05700	COG0714	Associated with various cellular activities
HPY09_RS05725	COG2003	Belongs to the UPF0758 family
HPY09_RS05765	COG3311	Transcriptional regulator
HPY09_RS05770	COG0582	viral genome integration into host DNA
HPY09_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_RS05795	COG3008	intermembrane lipid transfer
HPY09_RS05795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPY09_RS05800	COG2995	paraquat-inducible protein a
HPY09_RS05805	COG0668	transmembrane transport
HPY09_RS05825	COG1309	transcriptional regulator
HPY09_RS05830	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_RS05855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY09_RS05860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPY09_RS05865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPY09_RS05870	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPY09_RS05885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPY09_RS05890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY09_RS05895	COG0297	glycogen (starch) synthase activity
HPY09_RS05915	COG3070	regulator of competence-specific genes
HPY09_RS05920	COG1609	Transcriptional regulator
HPY09_RS05930	COG0745	RESPONSE REGULATOR receiver
HPY09_RS05935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY09_RS05940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY09_RS05945	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HPY09_RS05950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPY09_RS05965	COG1280	lysine exporter protein (LysE YggA)
HPY09_RS05970	COG1032	radical SAM domain protein
HPY09_RS05975	COG5001	Diguanylate cyclase
HPY09_RS05980	COG0612	Peptidase, M16
HPY09_RS05995	COG0583	DNA-binding transcription factor activity
HPY09_RS06000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPY09_RS06010	COG2350	Protein conserved in bacteria
HPY09_RS06015	COG1607	acyl-coa hydrolase
HPY09_RS06030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPY09_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY09_RS06045	COG2116	formate transmembrane transporter activity
HPY09_RS06050	COG4459	periplasmic nitrate reductase
HPY09_RS06055	COG3005	denitrification pathway
HPY09_RS06060	COG0243	molybdopterin cofactor binding
HPY09_RS06080	COG1227	inorganic diphosphatase activity
HPY09_RS06100	COG4172	Belongs to the ABC transporter superfamily
HPY09_RS06115	COG4168	peptide transport system, permease
HPY09_RS06125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPY09_RS06130	COG1842	Phage shock protein A
HPY09_RS06145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_RS06160	COG2818	Glycosylase
HPY09_RS06165	COG0626	cystathionine gamma-synthase activity
HPY09_RS06175	COG0733	neurotransmitter:sodium symporter activity
HPY09_RS06180	COG0564	pseudouridine synthase activity
HPY09_RS06185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPY09_RS06190	COG4136	ATPase activity
HPY09_RS06195	COG4135	transport system, permease component
HPY09_RS06200	COG4134	Bacterial extracellular solute-binding protein
HPY09_RS06210	COG3313	Fe-S protein
HPY09_RS06220	COG0814	amino acid
HPY09_RS06230	COG2239	Acts as a magnesium transporter
HPY09_RS06235	COG2205	protein histidine kinase activity
HPY09_RS06235	COG0784	Response regulator, receiver
HPY09_RS06250	COG4934	collagen metabolic process
HPY09_RS06285	COG0840	transmembrane signaling receptor activity
HPY09_RS06295	COG4251	negative regulation of phosphorylation
HPY09_RS06295	COG3706	GGDEF domain
HPY09_RS06295	COG2203	Gaf domain
HPY09_RS06295	COG5001	Diguanylate cyclase
HPY09_RS06300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPY09_RS06305	COG5002	protein histidine kinase activity
HPY09_RS06320	COG1061	Type III restriction enzyme res subunit
HPY09_RS06325	COG1187	pseudouridine synthase activity
HPY09_RS06330	COG2814	Major facilitator Superfamily
HPY09_RS06340	COG0702	epimerase
HPY09_RS06345	COG0534	Mate efflux family protein
HPY09_RS06350	COG4181	ATPase activity
HPY09_RS06365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPY09_RS06375	COG1748	Saccharopine dehydrogenase
HPY09_RS06390	COG1538	Outer membrane efflux protein
HPY09_RS06410	COG0583	DNA-binding transcription factor activity
HPY09_RS06420	COG1451	nucleotide metabolic process
HPY09_RS06435	COG3063	Type IV pilus biogenesis stability protein PilW
HPY09_RS06440	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPY09_RS06460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_RS06475	COG3290	protein histidine kinase activity
HPY09_RS06480	COG4565	transcriptional regulatory protein
HPY09_RS06490	COG0784	Response regulator, receiver
HPY09_RS06490	COG0835	chemotaxis
HPY09_RS06540	COG1085	galactose-1-phosphate uridylyltransferase
HPY09_RS06545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPY09_RS06550	COG2017	converts alpha-aldose to the beta-anomer
HPY09_RS06565	COG3527	Alpha-acetolactate decarboxylase
HPY09_RS06575	COG3064	Membrane
HPY09_RS06585	COG0753	catalase activity
HPY09_RS06605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY09_RS06655	COG1271	oxidase subunit
HPY09_RS06660	COG1294	oxidase, subunit
HPY09_RS06665	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPY09_RS06665	COG1136	(ABC) transporter
HPY09_RS06670	COG0577	efflux transmembrane transporter activity
HPY09_RS06670	COG1136	(ABC) transporter
HPY09_RS06675	COG1136	(ABC) transporter
HPY09_RS06675	COG0577	efflux transmembrane transporter activity
HPY09_RS06725	COG2816	NAD+ diphosphatase activity
HPY09_RS06730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPY09_RS06745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY09_RS06755	COG2723	6-phospho-beta-galactosidase activity
HPY09_RS06760	COG1609	Transcriptional regulator
HPY09_RS06765	COG0251	oxidation-reduction process
HPY09_RS06770	COG2731	YhcH YjgK YiaL family protein
HPY09_RS06775	COG0584	glycerophosphoryl diester phosphodiesterase
HPY09_RS06780	COG1349	DNA-binding transcription factor activity
HPY09_RS06785	COG3842	ATPase activity
HPY09_RS06790	COG0395	ABC-type sugar transport system, permease component
HPY09_RS06795	COG1175	transmembrane transport
HPY09_RS06810	COG0811	peptide transport
HPY09_RS06815	COG0811	peptide transport
HPY09_RS06820	COG0848	biopolymer transport protein
HPY09_RS06825	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY09_RS06835	COG1793	dna ligase
HPY09_RS06845	COG0534	Mate efflux family protein
HPY09_RS06855	COG3001	Fructosamine kinase
HPY09_RS06865	COG0791	NLP P60 protein
HPY09_RS06870	COG0840	transmembrane signaling receptor activity
HPY09_RS06885	COG1940	carbohydrate kinase activity
HPY09_RS06905	COG0746	molybdenum cofactor guanylyltransferase activity
HPY09_RS06910	COG3842	ATPase activity
HPY09_RS06915	COG4662	Binding-protein-dependent transport system inner membrane component
HPY09_RS06925	COG2204	response regulator
HPY09_RS06930	COG3852	Histidine kinase
HPY09_RS06935	COG0488	(ABC) transporter
HPY09_RS06940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPY09_RS06970	COG0243	molybdopterin cofactor binding
HPY09_RS06970	COG3383	formate dehydrogenase (NAD+) activity
HPY09_RS06975	COG0437	4 iron, 4 sulfur cluster binding
HPY09_RS06990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPY09_RS06995	COG1666	GTP binding
HPY09_RS07000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY09_RS07015	COG2996	Protein conserved in bacteria
HPY09_RS07025	COG3008	intermembrane lipid transfer
HPY09_RS07030	COG2995	paraquat-inducible protein a
HPY09_RS07035	COG1132	(ABC) transporter
HPY09_RS07040	COG1956	GAF domain-containing protein
HPY09_RS07045	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPY09_RS07060	COG0308	aminopeptidase N
HPY09_RS07075	COG0167	dihydroorotate dehydrogenase activity
HPY09_RS07085	COG0116	Belongs to the methyltransferase superfamily
HPY09_RS07085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY09_RS07110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPY09_RS07115	COG1067	ATP-dependent peptidase activity
HPY09_RS07120	COG3120	sequence-specific DNA binding
HPY09_RS07220	COG1073	alpha beta
HPY09_RS07220	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPY09_RS07220	COG3064	Membrane
HPY09_RS07225	COG2994	toxin metabolic process
HPY09_RS07250	COG0784	Response regulator, receiver
HPY09_RS07250	COG2205	protein histidine kinase activity
HPY09_RS07265	COG3278	Belongs to the heme-copper respiratory oxidase family
HPY09_RS07280	COG2010	Cytochrome c
HPY09_RS07290	COG2217	Heavy metal translocating P-type atpase
HPY09_RS07305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPY09_RS07310	COG0589	response to stress
HPY09_RS07315	COG0037	tRNA processing
HPY09_RS07335	COG3842	ATPase activity
HPY09_RS07345	COG1177	transmembrane transport
HPY09_RS07355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY09_RS07370	COG1115	amino acid carrier protein
HPY09_RS07375	COG1280	lysine exporter protein (LysE YggA)
HPY09_RS07405	COG3501	Rhs element vgr protein
HPY09_RS07415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPY09_RS07435	COG0513	Belongs to the DEAD box helicase family
HPY09_RS07440	COG2076	Multidrug Resistance protein
HPY09_RS07445	COG0415	Belongs to the DNA photolyase family
HPY09_RS07450	COG0477	Major facilitator Superfamily
HPY09_RS07455	COG0583	DNA-binding transcription factor activity
HPY09_RS07465	COG0402	S-adenosylhomocysteine deaminase activity
HPY09_RS07470	COG0095	Lipoate-protein ligase
HPY09_RS07475	COG0443	Heat shock 70 kDa protein
HPY09_RS07485	COG1643	Atp-dependent helicase
HPY09_RS07515	COG0443	Heat shock 70 kDa protein
HPY09_RS07520	COG0443	Heat shock 70 kDa protein
HPY09_RS07525	COG3706	GGDEF domain
HPY09_RS07555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPY09_RS07560	COG0602	queuosine metabolic process
HPY09_RS07565	COG0561	phosphatase activity
HPY09_RS07575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_RS07580	COG4597	amino acid ABC transporter
HPY09_RS07585	COG0765	amino acid transport
HPY09_RS07590	COG1126	abc transporter atp-binding protein
HPY09_RS07595	COG0670	Belongs to the BI1 family
HPY09_RS07600	COG2920	part of a sulfur-relay system
HPY09_RS07605	COG1254	Belongs to the acylphosphatase family
HPY09_RS07610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPY09_RS07615	COG3706	GGDEF domain
HPY09_RS07625	COG2205	protein histidine kinase activity
HPY09_RS07625	COG3437	response regulator, receiver
HPY09_RS07625	COG3850	Histidine kinase
HPY09_RS07625	COG4999	Histidine kinase
HPY09_RS07630	COG3437	response regulator, receiver
HPY09_RS07635	COG0625	glutathione transferase activity
HPY09_RS07645	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPY09_RS07655	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY09_RS07670	COG3385	transposase activity
HPY09_RS07690	COG0372	Belongs to the citrate synthase family
HPY09_RS07695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPY09_RS07720	COG0583	DNA-binding transcription factor activity
HPY09_RS07725	COG4771	TonB-dependent receptor
HPY09_RS07770	COG1129	ABC transporter
HPY09_RS07795	COG0745	RESPONSE REGULATOR receiver
HPY09_RS07800	COG5002	protein histidine kinase activity
HPY09_RS07805	COG3713	MltA-interacting MipA family protein
HPY09_RS07810	COG2990	Protein conserved in bacteria
HPY09_RS07820	COG4191	Histidine kinase
HPY09_RS07820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_RS07825	COG0471	metal ion transport
HPY09_RS07835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY09_RS07850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_RS07860	COG3768	UPF0283 membrane protein
HPY09_RS07865	COG3106	COG3106 Predicted ATPase
HPY09_RS07880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY09_RS07885	COG0494	nUDIX hydrolase
HPY09_RS07890	COG0814	amino acid
HPY09_RS07895	COG1760	l-serine dehydratase
HPY09_RS07900	COG3385	transposase activity
HPY09_RS07905	COG0720	synthase
HPY09_RS07910	COG0840	transmembrane signaling receptor activity
HPY09_RS07915	COG0017	Asparaginyl-tRNA synthetase
HPY09_RS07920	COG0351	phosphomethylpyrimidine kinase
HPY09_RS07925	COG2770	Histidine kinase
HPY09_RS07925	COG3437	response regulator, receiver
HPY09_RS07930	COG1448	Aminotransferase
HPY09_RS07945	COG0840	transmembrane signaling receptor activity
HPY09_RS07950	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HPY09_RS07955	COG2943	transferase activity, transferring hexosyl groups
HPY09_RS07960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY09_RS07965	COG1846	Transcriptional regulator
HPY09_RS07990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY09_RS08005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPY09_RS08010	COG3108	Peptidase M15
HPY09_RS08045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPY09_RS08055	COG2814	Major facilitator Superfamily
HPY09_RS08075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPY09_RS08080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY09_RS08085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPY09_RS08130	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HPY09_RS08135	COG4139	cobalamin transport
HPY09_RS08140	COG2988	succinylglutamate desuccinylase activity
HPY09_RS08155	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPY09_RS08160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPY09_RS08165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_RS08175	COG2925	Exonuclease
HPY09_RS08180	COG1380	Effector of murein hydrolase LrgA
HPY09_RS08185	COG1346	cytolysis
HPY09_RS08220	COG0776	regulation of translation
HPY09_RS08225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_RS08225	COG0072	phenylalanine-tRNA ligase activity
HPY09_RS08230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPY09_RS08270	COG0322	excinuclease ABC activity
HPY09_RS08275	COG2197	response regulator
HPY09_RS08280	COG0417	DNA replication proofreading
HPY09_RS08285	COG5001	Diguanylate cyclase
HPY09_RS08295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPY09_RS08300	COG3099	Belongs to the UPF0263 family
HPY09_RS08315	COG1228	amidohydrolase
HPY09_RS08320	COG0010	Belongs to the arginase family
HPY09_RS08325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPY09_RS08330	COG2986	histidine ammonia-lyase
HPY09_RS08350	COG0247	lactate metabolic process
HPY09_RS08350	COG0277	FAD linked oxidase domain protein
HPY09_RS08365	COG2885	chlorophyll binding
HPY09_RS08385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPY09_RS08395	COG0281	malic enzyme
HPY09_RS08405	COG2949	membrane
HPY09_RS08410	COG3706	GGDEF domain
HPY09_RS08415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPY09_RS08425	COG0492	ferredoxin-NADP+ reductase activity
HPY09_RS08430	COG4988	ABC transporter
HPY09_RS08435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPY09_RS08440	COG1187	pseudouridine synthase activity
HPY09_RS08445	COG0009	L-threonylcarbamoyladenylate synthase
HPY09_RS08450	COG0613	PHP domain protein
HPY09_RS08460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPY09_RS08465	COG0512	Glutamine amidotransferase of anthranilate synthase
HPY09_RS08470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPY09_RS08475	COG0134	indole-3-glycerol-phosphate synthase activity
HPY09_RS08475	COG0135	phosphoribosylanthranilate isomerase activity
HPY09_RS08480	COG0133	tryptophan synthase activity
HPY09_RS08485	COG0159	tryptophan synthase activity
HPY09_RS08495	COG1435	thymidine kinase activity
HPY09_RS08500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPY09_RS08505	COG1801	Protein of unknown function DUF72
HPY09_RS08510	COG4106	trans-aconitate 2-methyltransferase activity
HPY09_RS08515	COG0500	methyltransferase
HPY09_RS08520	COG4067	protein conserved in archaea
HPY09_RS08520	COG0189	ligase activity
HPY09_RS08535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPY09_RS08545	COG3852	Histidine kinase
HPY09_RS08560	COG3070	regulator of competence-specific genes
HPY09_RS08570	COG2431	L-lysine efflux transmembrane transporter activity
HPY09_RS08580	COG0076	glutamate decarboxylase activity
HPY09_RS08585	COG1737	Transcriptional regulator
HPY09_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
HPY09_RS08590	COG1454	alcohol dehydrogenase
HPY09_RS08595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPY09_RS08600	COG3273	potassium ion transport
HPY09_RS08600	COG2985	domain, Protein
HPY09_RS08605	COG0542	response to heat
HPY09_RS08610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPY09_RS08615	COG1278	Cold shock
HPY09_RS08625	COG1187	pseudouridine synthase activity
HPY09_RS08630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPY09_RS08630	COG0140	phosphoribosyl-ATP diphosphatase activity
HPY09_RS08635	COG0107	imidazoleglycerol-phosphate synthase activity
HPY09_RS08640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPY09_RS08645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPY09_RS08650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY09_RS08650	COG0131	Imidazoleglycerol-phosphate dehydratase
HPY09_RS08655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPY09_RS08660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPY09_RS08665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPY09_RS08670	COG1757	Na H antiporter
HPY09_RS08675	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY09_RS08680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_RS08685	COG0482	sulfurtransferase activity
HPY09_RS08690	COG2915	High frequency lysogenization protein hflD homolog
HPY09_RS08695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPY09_RS08705	COG2268	Band 7 protein
HPY09_RS08715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY09_RS08740	COG0501	Belongs to the peptidase M48B family
HPY09_RS08750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPY09_RS08755	COG2226	methyltransferase
HPY09_RS08760	COG0156	8-amino-7-oxononanoate synthase activity
HPY09_RS08765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPY09_RS08770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPY09_RS08775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPY09_RS08780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPY09_RS08785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPY09_RS08790	COG0653	protein targeting
HPY09_RS08795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY09_RS08800	COG3706	GGDEF domain
HPY09_RS08810	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPY09_RS08820	COG4628	conserved protein (DUF2132)
HPY09_RS08825	COG3092	negative regulation of chromosome organization
HPY09_RS08830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY09_RS08835	COG0857	belongs to the CobB CobQ family
HPY09_RS08835	COG0280	phosphate acetyltransferase
HPY09_RS08840	COG0435	Glutathione S-transferase
HPY09_RS08845	COG4608	Belongs to the ABC transporter superfamily
HPY09_RS08850	COG0444	Belongs to the ABC transporter superfamily
HPY09_RS08855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_RS08860	COG0601	transmembrane transport
HPY09_RS08880	COG2204	response regulator
HPY09_RS08885	COG5001	Diguanylate cyclase
HPY09_RS08885	COG3300	MHYT domain
HPY09_RS08890	COG4191	Histidine kinase
HPY09_RS08895	COG5002	protein histidine kinase activity
HPY09_RS08905	COG2201	protein-glutamate methylesterase activity
HPY09_RS08920	COG0009	L-threonylcarbamoyladenylate synthase
HPY09_RS08940	COG1881	PFAM PEBP family protein
HPY09_RS08965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY09_RS08970	COG0640	Transcriptional regulator
HPY09_RS08980	COG3706	GGDEF domain
HPY09_RS09000	COG1946	Acyl-CoA thioesterase
HPY09_RS09005	COG1522	sequence-specific DNA binding
HPY09_RS09015	COG0616	signal peptide processing
HPY09_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
HPY09_RS09030	COG2983	Belongs to the UPF0260 family
HPY09_RS09045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPY09_RS09050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPY09_RS09055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPY09_RS09060	COG2832	Protein of unknown function (DUF454)
HPY09_RS09065	COG0745	RESPONSE REGULATOR receiver
HPY09_RS09070	COG0583	DNA-binding transcription factor activity
HPY09_RS09075	COG0778	Nitroreductase
HPY09_RS09080	COG1024	Enoyl-CoA hydratase
HPY09_RS09080	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY09_RS09085	COG0183	Belongs to the thiolase family
HPY09_RS09100	COG2067	long-chain fatty acid transport protein
HPY09_RS09105	COG2067	long-chain fatty acid transport protein
HPY09_RS09110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY09_RS09115	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPY09_RS09120	COG2982	Protein involved in outer membrane biogenesis
HPY09_RS09125	COG0572	uridine kinase
HPY09_RS09130	COG0489	protein tyrosine kinase activity
HPY09_RS09135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_RS09135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPY09_RS09145	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY09_RS09155	COG0617	tRNA 3'-terminal CCA addition
HPY09_RS09155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPY09_RS09155	COG0517	IMP dehydrogenase activity
HPY09_RS09160	COG2199	diguanylate cyclase activity
HPY09_RS09165	COG0314	molybdopterin synthase activity
HPY09_RS09170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPY09_RS09175	COG0315	cyclic pyranopterin monophosphate synthase activity
HPY09_RS09180	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPY09_RS09185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPY09_RS09190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPY09_RS09195	COG2198	Histidine kinase
HPY09_RS09200	COG2204	response regulator
HPY09_RS09205	COG0556	nucleotide-excision repair
HPY09_RS09215	COG4657	Part of a membrane complex involved in electron transport
HPY09_RS09220	COG2878	Part of a membrane complex involved in electron transport
HPY09_RS09225	COG4656	Part of a membrane complex involved in electron transport
HPY09_RS09240	COG4660	Part of a membrane complex involved in electron transport
HPY09_RS09245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPY09_RS09250	COG0346	lactoylglutathione lyase activity
HPY09_RS09265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPY09_RS09270	COG2056	Na+-H+ antiporter family
HPY09_RS09275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPY09_RS09280	COG1286	toxin biosynthetic process
HPY09_RS09285	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPY09_RS09290	COG0285	dihydrofolate synthase activity
HPY09_RS09295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPY09_RS09300	COG0101	tRNA pseudouridine synthase activity
HPY09_RS09315	COG1263	PTS System
HPY09_RS09315	COG2190	(PTS) system
HPY09_RS09315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_RS09320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPY09_RS09325	COG1846	Transcriptional regulator
HPY09_RS09325	COG1940	carbohydrate kinase activity
HPY09_RS09330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY09_RS09330	COG4651	solute:proton antiporter activity
HPY09_RS09350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPY09_RS09355	COG0563	adenylate kinase activity
HPY09_RS09360	COG0326	Molecular chaperone. Has ATPase activity
HPY09_RS09365	COG3710	Transcriptional regulator
HPY09_RS09380	COG0622	Phosphoesterase
HPY09_RS09385	COG1090	epimerase
HPY09_RS09390	COG0300	oxidoreductase activity
HPY09_RS09395	COG3118	belongs to the thioredoxin family
HPY09_RS09400	COG0330	HflC and HflK could
HPY09_RS09405	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPY09_RS09410	COG0789	Transcriptional regulator
HPY09_RS09425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY09_RS09430	COG3115	cell septum assembly
HPY09_RS09435	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HPY09_RS09440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPY09_RS09445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_RS09455	COG2190	(PTS) system
HPY09_RS09460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPY09_RS09465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPY09_RS09470	COG1702	phosphate starvation-inducible protein PhoH
HPY09_RS09475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPY09_RS09480	COG4535	Mg2 and Co2 transporter CorC
HPY09_RS09485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPY09_RS09490	COG2888	peptidyl-tyrosine sulfation
HPY09_RS09495	COG0495	leucyl-tRNA aminoacylation
HPY09_RS09500	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HPY09_RS09505	COG1466	dna polymerase III delta subunit
HPY09_RS09510	COG0799	negative regulation of ribosome biogenesis
HPY09_RS09515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPY09_RS09520	COG0768	penicillin binding
HPY09_RS09525	COG0772	Belongs to the SEDS family
HPY09_RS09530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPY09_RS09535	COG1686	Belongs to the peptidase S11 family
HPY09_RS09540	COG2921	Belongs to the UPF0250 family
HPY09_RS09545	COG0321	lipoyl(octanoyl) transferase activity
HPY09_RS09550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPY09_RS09560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY09_RS09585	COG1596	polysaccharide export
HPY09_RS09595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY09_RS09625	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPY09_RS09635	COG0438	transferase activity, transferring glycosyl groups
HPY09_RS09645	COG1045	serine acetyltransferase
HPY09_RS09665	COG0110	maltose O-acetyltransferase activity
HPY09_RS09670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPY09_RS09675	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPY09_RS09680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPY09_RS09685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY09_RS09715	COG0366	Alpha amylase catalytic
HPY09_RS09720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_RS09720	COG1263	PTS System
HPY09_RS09725	COG1609	Transcriptional regulator
HPY09_RS09730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPY09_RS09735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPY09_RS09740	COG2011	ABC-type metal ion transport system permease component
HPY09_RS09745	COG1464	Belongs to the NlpA lipoprotein family
HPY09_RS09750	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HPY09_RS09760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY09_RS09760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPY09_RS09770	COG3706	GGDEF domain
HPY09_RS09775	COG1611	Belongs to the LOG family
HPY09_RS09780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPY09_RS09785	COG2363	Small membrane protein
HPY09_RS09790	COG0583	DNA-binding transcription factor activity
HPY09_RS09795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPY09_RS09795	COG0301	tRNA thio-modification
HPY09_RS09805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPY09_RS09810	COG1722	exodeoxyribonuclease VII activity
HPY09_RS09815	COG0142	geranyltranstransferase activity
HPY09_RS09820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPY09_RS09825	COG0564	pseudouridine synthase activity
HPY09_RS09830	COG3098	single-species biofilm formation
HPY09_RS09845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_RS09855	COG1671	Belongs to the UPF0178 family
HPY09_RS09860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY09_RS09865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPY09_RS09870	COG0254	rRNA binding
HPY09_RS09875	COG1720	tRNA m6t6A37 methyltransferase activity
HPY09_RS09880	COG0442	prolyl-tRNA aminoacylation
HPY09_RS09900	COG0047	phosphoribosylformylglycinamidine synthase activity
HPY09_RS09900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPY09_RS09910	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HPY09_RS09920	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPY09_RS09950	COG0484	heat shock protein binding
HPY09_RS09960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPY09_RS09965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPY09_RS09970	COG0497	DNA recombination
HPY09_RS09975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_RS09980	COG2914	Belongs to the UPF0125 (RnfH) family
HPY09_RS09985	COG2867	negative regulation of translational initiation
HPY09_RS09990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPY09_RS10020	COG1104	cysteine desulfurase activity
HPY09_RS10085	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPY09_RS10090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPY09_RS10095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPY09_RS10115	COG3051	citrate lyase alpha subunit
HPY09_RS10120	COG2301	Belongs to the HpcH HpaI aldolase family
HPY09_RS10130	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPY09_RS10145	COG5016	pyruvate
HPY09_RS10145	COG0511	ligase activity, forming carbon-carbon bonds
HPY09_RS10150	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY09_RS10160	COG4565	transcriptional regulatory protein
HPY09_RS10185	COG1115	amino acid carrier protein
HPY09_RS10190	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPY09_RS10195	COG0583	DNA-binding transcription factor activity
HPY09_RS10205	COG1120	ATPase activity
HPY09_RS10210	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_RS10215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_RS10220	COG4592	Periplasmic binding protein
HPY09_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
HPY09_RS10235	COG1169	isochorismate synthase
HPY09_RS10240	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY09_RS10245	COG3433	isochorismatase activity
HPY09_RS10245	COG1535	isochorismatase
HPY09_RS10250	COG1584	GPR1 FUN34 yaaH family protein
HPY09_RS10260	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPY09_RS10270	COG0519	Catalyzes the synthesis of GMP from XMP
HPY09_RS10270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPY09_RS10275	COG0517	IMP dehydrogenase activity
HPY09_RS10275	COG0516	GMP reductase activity
HPY09_RS10280	COG1570	exodeoxyribonuclease VII activity
HPY09_RS10295	COG1160	GTP binding
HPY09_RS10300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_RS10305	COG2976	Protein conserved in bacteria
HPY09_RS10310	COG0124	histidyl-tRNA synthetase
HPY09_RS10315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPY09_RS10325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPY09_RS10330	COG0105	UTP biosynthetic process
HPY09_RS10340	COG2975	iron-sulfur cluster assembly
HPY09_RS10345	COG0633	Ferredoxin
HPY09_RS10365	COG0822	iron-sulfur transferase activity
HPY09_RS10375	COG1959	2 iron, 2 sulfur cluster binding
HPY09_RS10385	COG0483	inositol monophosphate 1-phosphatase activity
HPY09_RS10390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_RS10395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_RS10400	COG1862	Preprotein translocase
HPY09_RS10410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPY09_RS10415	COG0517	IMP dehydrogenase activity
HPY09_RS10425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPY09_RS10430	COG0583	DNA-binding transcription factor activity
HPY09_RS10435	COG0450	alkyl hydroperoxide reductase
HPY09_RS10440	COG3142	Participates in the control of copper homeostasis
HPY09_RS10455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY09_RS10460	COG0581	inorganic phosphate transmembrane transporter activity
HPY09_RS10470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPY09_RS10475	COG0248	Ppx GppA phosphatase
HPY09_RS10485	COG5002	protein histidine kinase activity
HPY09_RS10490	COG0745	RESPONSE REGULATOR receiver
HPY09_RS10505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY09_RS10550	COG0542	response to heat
HPY09_RS10560	COG0564	pseudouridine synthase activity
HPY09_RS10565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_RS10570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPY09_RS10575	COG0077	Prephenate dehydratase
HPY09_RS10575	COG1605	Chorismate mutase
HPY09_RS10580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY09_RS10585	COG5001	Diguanylate cyclase
HPY09_RS10595	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HPY09_RS10605	COG0488	(ABC) transporter
HPY09_RS10615	COG1605	Chorismate mutase
HPY09_RS10615	COG0287	Prephenate dehydrogenase
HPY09_RS10620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY09_RS10625	COG3275	phosphorelay sensor kinase activity
HPY09_RS10630	COG3279	Response regulator of the LytR AlgR family
HPY09_RS10640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPY09_RS10645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY09_RS10660	COG1966	Carbon starvation protein
HPY09_RS10665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPY09_RS10670	COG1047	Peptidyl-prolyl cis-trans
HPY09_RS10675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPY09_RS10685	COG0196	riboflavin kinase activity
HPY09_RS10690	COG0728	peptidoglycan biosynthetic process
HPY09_RS10695	COG0268	Binds directly to 16S ribosomal RNA
HPY09_RS10700	COG0640	Transcriptional regulator
HPY09_RS10705	COG0583	DNA-binding transcription factor activity
HPY09_RS10710	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPY09_RS10715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HPY09_RS10720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPY09_RS10725	COG0730	response to heat
HPY09_RS10730	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPY09_RS10735	COG0494	nUDIX hydrolase
HPY09_RS10740	COG3066	DNA modification
HPY09_RS10745	COG0667	Aldo Keto reductase
HPY09_RS10755	COG2204	response regulator
HPY09_RS10760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPY09_RS10780	COG0513	Belongs to the DEAD box helicase family
HPY09_RS10805	COG3153	acetyltransferase
HPY09_RS10810	COG3154	lipid carrier protein
HPY09_RS10820	COG0826	peptidase U32
HPY09_RS10825	COG0826	peptidase U32
HPY09_RS10850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPY09_RS10860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPY09_RS10865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPY09_RS10870	COG0195	Participates in both transcription termination and antitermination
HPY09_RS10875	COG0779	Required for maturation of 30S ribosomal subunits
HPY09_RS10890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY09_RS10900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPY09_RS10905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPY09_RS10910	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPY09_RS10915	COG1534	Rna-binding protein
HPY09_RS10920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY09_RS10925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY09_RS10930	COG2027	D-alanyl-D-alanine carboxypeptidase
HPY09_RS10935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY09_RS10940	COG0739	heme binding
HPY09_RS10955	COG0316	Belongs to the HesB IscA family
HPY09_RS10960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPY09_RS10965	COG0628	permease
HPY09_RS10970	COG2813	Specifically methylates the guanine in position
HPY09_RS10975	COG0784	Response regulator, receiver
HPY09_RS10975	COG2205	protein histidine kinase activity
HPY09_RS10980	COG0747	negative chemotaxis
HPY09_RS10990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_RS10995	COG0444	Belongs to the ABC transporter superfamily
HPY09_RS11000	COG4608	Belongs to the ABC transporter superfamily
HPY09_RS11010	COG2971	BadF BadG BcrA BcrD
HPY09_RS11030	COG3842	ATPase activity
HPY09_RS11040	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY09_RS11045	COG0004	ammonium transporteR
HPY09_RS11050	COG0347	Belongs to the P(II) protein family
HPY09_RS11055	COG3112	Uncharacterised protein family (UPF0231)
HPY09_RS11060	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPY09_RS11065	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPY09_RS11070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPY09_RS11075	COG1643	Atp-dependent helicase
HPY09_RS11085	COG1489	DNA binding
HPY09_RS11095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPY09_RS11105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY09_RS11110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPY09_RS11115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPY09_RS11120	COG0842	Transport permease protein
HPY09_RS11125	COG1131	(ABC) transporter
HPY09_RS11130	COG0659	secondary active sulfate transmembrane transporter activity
HPY09_RS11135	COG0288	reversible hydration of carbon dioxide
HPY09_RS11150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPY09_RS11155	COG3107	peptidoglycan biosynthetic process
HPY09_RS11160	COG0792	nuclease activity
HPY09_RS11165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPY09_RS11170	COG2823	Periplasmic or secreted lipoprotein
HPY09_RS11175	COG2969	positive regulation of protein catabolic process
HPY09_RS11180	COG0625	glutathione transferase activity
HPY09_RS11185	COG2857	Cytochrome c1
HPY09_RS11190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPY09_RS11195	COG0723	plastoquinol--plastocyanin reductase activity
HPY09_RS11200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPY09_RS11205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPY09_RS11210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPY09_RS11220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY09_RS11225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPY09_RS11230	COG0335	large ribosomal subunit rRNA binding
HPY09_RS11235	COG0336	Belongs to the RNA methyltransferase TrmD family
HPY09_RS11240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPY09_RS11245	COG0228	four-way junction DNA binding
HPY09_RS11250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPY09_RS11255	COG4137	Cytochrome C assembly protein
HPY09_RS11260	COG4536	flavin adenine dinucleotide binding
HPY09_RS11265	COG1854	S-ribosylhomocysteine lyase activity
HPY09_RS11270	COG2918	glutathione biosynthetic process
HPY09_RS11275	COG0612	Peptidase, M16
HPY09_RS11280	COG1238	metal cluster binding
HPY09_RS11290	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPY09_RS11295	COG0511	ligase activity, forming carbon-carbon bonds
HPY09_RS11295	COG5016	pyruvate
HPY09_RS11300	COG3630	sodium ion export across plasma membrane
HPY09_RS11345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPY09_RS11355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPY09_RS11365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPY09_RS11375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPY09_RS11380	COG4208	sulfate ABC transporter
HPY09_RS11400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPY09_RS11405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPY09_RS11415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPY09_RS11420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPY09_RS11425	COG0585	pseudouridine synthase activity
HPY09_RS11430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPY09_RS11435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPY09_RS11440	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPY09_RS11445	COG1968	undecaprenyl-diphosphatase activity
HPY09_RS11450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPY09_RS11455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPY09_RS11460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPY09_RS11470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPY09_RS11475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPY09_RS11480	COG1610	YqeY-like protein
HPY09_RS11485	COG0358	DNA primase activity
HPY09_RS11505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPY09_RS11510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPY09_RS11515	COG1349	DNA-binding transcription factor activity
HPY09_RS11535	COG1279	arginine transmembrane transporter activity
HPY09_RS11540	COG0668	transmembrane transport
HPY09_RS11550	COG0126	phosphoglycerate kinase activity
HPY09_RS11555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPY09_RS11560	COG4771	TonB-dependent receptor
HPY09_RS11565	COG0583	DNA-binding transcription factor activity
HPY09_RS11570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY09_RS11575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPY09_RS11585	COG2356	endonuclease I
HPY09_RS11595	COG0189	ligase activity
HPY09_RS11600	COG1678	Uncharacterized ACR, COG1678
HPY09_RS11605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPY09_RS11610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPY09_RS11630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPY09_RS11635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPY09_RS11640	COG0762	integral membrane protein
HPY09_RS11645	COG1872	DUF167
HPY09_RS11655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPY09_RS11660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPY09_RS11665	COG2066	Belongs to the glutaminase family
HPY09_RS11670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPY09_RS11675	COG1194	a g-specific adenine glycosylase
HPY09_RS11680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPY09_RS11685	COG0741	lytic transglycosylase activity
HPY09_RS11710	COG0840	transmembrane signaling receptor activity
HPY09_RS11740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPY09_RS11745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPY09_RS11750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY09_RS11755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPY09_RS11760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPY09_RS11765	COG2967	ApaG domain
HPY09_RS11770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPY09_RS11780	COG3610	response to peptide
HPY09_RS11785	COG2966	Psort location CytoplasmicMembrane, score
HPY09_RS11790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPY09_RS11795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPY09_RS11800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPY09_RS11805	COG0142	geranyltranstransferase activity
HPY09_RS11810	COG0531	amino acid
HPY09_RS11815	COG0039	L-malate dehydrogenase activity
HPY09_RS11820	COG1438	arginine binding
HPY09_RS11825	COG2358	TRAP transporter, solute receptor (TAXI family
HPY09_RS11835	COG0589	response to stress
HPY09_RS11855	COG2235	arginine
HPY09_RS11860	COG0312	modulator of DNA gyrase
HPY09_RS11865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY09_RS11870	COG3164	Protein of unknown function
HPY09_RS11875	COG1530	ribonuclease E activity
HPY09_RS11880	COG0424	maF-like protein
HPY09_RS11885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPY09_RS11890	COG1792	Involved in formation and maintenance of cell shape
HPY09_RS11895	COG1077	Cell shape determining protein MreB Mrl
HPY09_RS11940	COG1459	type II secretion system
HPY09_RS11945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPY09_RS11955	COG3267	Type II secretory pathway component ExeA
HPY09_RS11955	COG3409	Peptidoglycan-binding domain 1 protein
HPY09_RS11980	COG2200	EAL domain
HPY09_RS11980	COG2199	diguanylate cyclase activity
HPY09_RS11985	COG0629	single-stranded DNA binding
HPY09_RS12000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPY09_RS12010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY09_RS12015	COG0527	aspartate kinase activity
HPY09_RS12020	COG0646	methionine synthase
HPY09_RS12020	COG1410	methionine synthase
HPY09_RS12060	COG0175	sulfate reduction
HPY09_RS12070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY09_RS12095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY09_RS12100	COG0735	belongs to the Fur family
HPY09_RS12115	COG0166	Belongs to the GPI family
HPY09_RS12120	COG0432	Pfam Uncharacterised protein family UPF0047
HPY09_RS12125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPY09_RS12140	COG0359	binds to the 23S rRNA
HPY09_RS12145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPY09_RS12150	COG2965	DNA replication, synthesis of RNA primer
HPY09_RS12155	COG0360	Binds together with S18 to 16S ribosomal RNA
HPY09_RS12165	COG2906	2 iron, 2 sulfur cluster binding
HPY09_RS12170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY09_RS12175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPY09_RS12180	COG0049	tRNA binding
HPY09_RS12195	COG2923	Belongs to the DsrF TusC family
HPY09_RS12200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPY09_RS12205	COG2964	Protein conserved in bacteria
HPY09_RS12210	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY09_RS12220	COG2900	Belongs to the SlyX family
HPY09_RS12225	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPY09_RS12230	COG0330	HflC and HflK could
HPY09_RS12235	COG0330	HflC and HflK could
HPY09_RS12240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPY09_RS12245	COG1923	regulation of RNA biosynthetic process
HPY09_RS12250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPY09_RS12255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPY09_RS12265	COG0802	atpase or kinase
HPY09_RS12270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPY09_RS12320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPY09_RS12325	COG1162	GTPase activity
HPY09_RS12330	COG0688	phosphatidylethanolamine metabolic process
HPY09_RS12335	COG0471	metal ion transport
HPY09_RS12345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPY09_RS12350	COG4942	peptidase
HPY09_RS12365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPY09_RS12370	COG2816	NAD+ diphosphatase activity
HPY09_RS12375	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HPY09_RS12380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPY09_RS12385	COG0085	RNA polymerase activity
HPY09_RS12390	COG0222	ribosome binding
HPY09_RS12395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPY09_RS12405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPY09_RS12410	COG0250	Participates in transcription elongation, termination and antitermination
HPY09_RS12415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPY09_RS12420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPY09_RS12445	COG1072	(Pantothenic acid kinase))
HPY09_RS12455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPY09_RS12465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPY09_RS12545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPY09_RS12560	COG3118	belongs to the thioredoxin family
HPY09_RS12565	COG0513	Belongs to the DEAD box helicase family
HPY09_RS12570	COG0248	Ppx GppA phosphatase
HPY09_RS12575	COG0784	Response regulator, receiver
HPY09_RS12575	COG2205	protein histidine kinase activity
HPY09_RS12580	COG2814	Major facilitator Superfamily
HPY09_RS12600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPY09_RS12605	COG0511	ligase activity, forming carbon-carbon bonds
HPY09_RS12610	COG0439	Biotin carboxylase
HPY09_RS12615	COG2264	protein methyltransferase activity
HPY09_RS12620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPY09_RS12625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HPY09_RS12630	COG1609	Transcriptional regulator
HPY09_RS12640	COG0387	Pfam Sodium calcium exchanger
HPY09_RS12645	COG0129	dihydroxy-acid dehydratase activity
HPY09_RS12650	COG3265	gluconokinase activity
HPY09_RS12660	COG0800	Aldolase
HPY09_RS12680	COG0840	transmembrane signaling receptor activity
HPY09_RS12690	COG0531	amino acid
HPY09_RS12695	COG3710	Transcriptional regulator
HPY09_RS12700	COG0789	Transcriptional regulator
HPY09_RS12715	COG0151	Belongs to the GarS family
HPY09_RS12725	COG0776	regulation of translation
HPY09_RS12730	COG1253	flavin adenine dinucleotide binding
HPY09_RS12735	COG3068	Protein conserved in bacteria
HPY09_RS12745	COG1573	uracil-dna glycosylase
HPY09_RS12750	COG0668	transmembrane transport
HPY09_RS12755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPY09_RS12760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPY09_RS12770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPY09_RS12810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPY09_RS12810	COG0517	IMP dehydrogenase activity
HPY09_RS12820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY09_RS12840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPY09_RS12855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPY09_RS12910	COG1086	Polysaccharide biosynthesis protein
HPY09_RS12915	COG0438	transferase activity, transferring glycosyl groups
HPY09_RS12945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPY09_RS12970	COG0859	PFAM glycosyl transferase family 9
HPY09_RS12980	COG1519	Transferase
HPY09_RS13005	COG3642	lipopolysaccharide core region biosynthetic process
HPY09_RS13010	COG0859	PFAM glycosyl transferase family 9
HPY09_RS13015	COG0463	Glycosyl transferase, family 2
HPY09_RS13020	COG0859	PFAM glycosyl transferase family 9
HPY09_RS13025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPY09_RS13030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPY09_RS13040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPY09_RS13045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPY09_RS13050	COG2003	Belongs to the UPF0758 family
HPY09_RS13060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPY09_RS13070	COG1309	transcriptional regulator
HPY09_RS13075	COG1560	Kdo2-lipid A biosynthetic process
HPY09_RS13080	COG1560	Kdo2-lipid A biosynthetic process
HPY09_RS13085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPY09_RS13090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPY09_RS13095	COG1561	YicC-like family, N-terminal region
HPY09_RS13100	COG2862	Uncharacterized protein family, UPF0114
HPY09_RS13105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY09_RS13110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_RS13110	COG1263	PTS System
HPY09_RS13115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPY09_RS13130	COG0514	ATP-dependent DNA helicase (RecQ)
HPY09_RS13135	COG2962	Rard protein
HPY09_RS13140	COG0405	Gamma-glutamyltransferase
HPY09_RS13150	COG1280	lysine exporter protein (LysE YggA)
HPY09_RS13155	COG0210	DNA helicase
HPY09_RS13165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPY09_RS13170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPY09_RS13180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_RS13190	COG0747	negative chemotaxis
HPY09_RS13240	COG1309	transcriptional regulator
HPY09_RS13245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPY09_RS13250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPY09_RS13255	COG2960	long-chain fatty acid transporting porin activity
HPY09_RS13260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPY09_RS13265	COG0583	DNA-binding transcription factor activity
HPY09_RS13335	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPY09_RS13340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPY09_RS13345	COG1739	Uncharacterized protein family UPF0029
HPY09_RS13350	COG1024	Enoyl-CoA hydratase
HPY09_RS13350	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPY09_RS13355	COG0183	Belongs to the thiolase family
HPY09_RS13360	COG0583	DNA-binding transcription factor activity
HPY09_RS13365	COG2814	Major facilitator Superfamily
HPY09_RS13375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPY09_RS13380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPY09_RS13385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPY09_RS13390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPY09_RS13395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPY09_RS13400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPY09_RS13410	COG0356	it plays a direct role in the translocation of protons across the membrane
HPY09_RS13415	COG3312	ion transport
HPY09_RS13420	COG1475	DNA binding
HPY09_RS13425	COG1192	Involved in chromosome partitioning
HPY09_RS13430	COG0357	Ribosomal RNA small subunit methyltransferase G
HPY09_RS13435	COG0445	tRNA wobble uridine modification
HPY09_RS13440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPY09_RS13445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPY09_RS13450	COG0706	membrane insertase activity
HPY09_RS13460	COG0594	ribonuclease P activity
HPY09_RS13465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPY09_RS13470	COG1126	abc transporter atp-binding protein
HPY09_RS13515	COG0217	transcriptional regulatory protein
HPY09_RS13520	COG2084	Dehydrogenase
HPY09_RS13535	COG2909	trisaccharide binding
HPY09_RS13540	COG0058	SHG alpha-glucan phosphorylase activity
HPY09_RS13550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPY09_RS13560	COG3501	Rhs element vgr protein
HPY09_RS13595	COG0471	metal ion transport
HPY09_RS13600	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HPY09_RS13630	COG0671	phosphoesterase, PA-phosphatase related
HPY09_RS13640	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPY09_RS13650	COG1999	signal sequence binding
HPY09_RS13665	COG0786	glutamate:sodium symporter activity
HPY09_RS13685	COG1566	PFAM secretion protein HlyD family protein
HPY09_RS13695	COG3706	GGDEF domain
HPY09_RS13710	COG0813	purine-nucleoside phosphorylase activity
HPY09_RS13715	COG3272	Protein of unknown function (DUF1722)
HPY09_RS13725	COG0415	Belongs to the DNA photolyase family
HPY09_RS13730	COG1388	LysM domain
HPY09_RS13730	COG1376	ErfK ybiS ycfS ynhG family protein
HPY09_RS13740	COG0513	Belongs to the DEAD box helicase family
HPY09_RS13745	COG1770	oligopeptidase
HPY09_RS13775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY09_RS13780	COG0573	inorganic phosphate transmembrane transporter activity
HPY09_RS13785	COG0581	inorganic phosphate transmembrane transporter activity
HPY09_RS13790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPY09_RS13810	COG0659	secondary active sulfate transmembrane transporter activity
HPY09_RS13820	COG0739	heme binding
HPY09_RS13825	COG3300	MHYT domain
HPY09_RS13825	COG5001	Diguanylate cyclase
HPY09_RS13830	COG0583	DNA-binding transcription factor activity
HPY09_RS13835	COG2814	Major facilitator Superfamily
HPY09_RS13855	COG1301	dicarboxylic acid transport
HPY09_RS13870	COG1342	Belongs to the UPF0251 family
HPY09_RS13905	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPY09_RS13910	COG0673	inositol 2-dehydrogenase activity
HPY09_RS13920	COG2200	EAL domain
HPY09_RS13920	COG2771	luxR family
HPY09_RS13925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY09_RS13935	COG0564	pseudouridine synthase activity
HPY09_RS14040	COG1869	D-ribose catabolic process
HPY09_RS14045	COG1129	ABC transporter
HPY09_RS14050	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPY09_RS14055	COG1879	ABC-type sugar transport system periplasmic component
HPY09_RS14060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_RS14065	COG1609	Transcriptional regulator
HPY09_RS14075	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPY09_RS14095	COG0584	glycerophosphoryl diester phosphodiesterase
HPY09_RS14100	COG2271	Major facilitator Superfamily
HPY09_RS14135	COG0579	oxidoreductase
HPY09_RS14145	COG0242	peptide deformylase activity
HPY09_RS14150	COG1017	nitric oxide dioxygenase activity
HPY09_RS14150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY09_RS14155	COG1320	monovalent cation:proton antiporter activity
HPY09_RS14180	COG2111	Na H antiporter
HPY09_RS14180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPY09_RS14190	COG0589	response to stress
HPY09_RS14195	COG0814	amino acid
HPY09_RS14210	COG3530	Putative quorum-sensing-regulated virulence factor
HPY09_RS14220	COG5002	protein histidine kinase activity
HPY09_RS14220	COG5001	Diguanylate cyclase
HPY09_RS14225	COG1278	Cold shock
HPY09_RS14240	COG2304	oxidoreductase activity
HPY09_RS14260	COG0714	Associated with various cellular activities
HPY09_RS14265	COG0840	transmembrane signaling receptor activity
HPY09_RS14280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPY09_RS14285	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPY09_RS14295	COG3604	Transcriptional regulator
HPY09_RS14300	COG1017	nitric oxide dioxygenase activity
HPY09_RS14300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPY09_RS14305	COG1278	Cold shock
HPY09_RS14310	COG3036	rescue of stalled ribosome
HPY09_RS14335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPY09_RS14335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPY09_RS14340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPY09_RS14350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPY09_RS14360	COG0516	GMP reductase activity
HPY09_RS14380	COG0513	Belongs to the DEAD box helicase family
HPY09_RS14385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPY09_RS14390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPY09_RS14400	COG3437	response regulator, receiver
HPY09_RS14400	COG0784	Response regulator, receiver
HPY09_RS14410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_RS14410	COG4191	Histidine kinase
HPY09_RS14420	COG1757	Na H antiporter
HPY09_RS14425	COG2814	Major facilitator Superfamily
HPY09_RS14435	COG3706	GGDEF domain
HPY09_RS14440	COG3240	lipase activity
HPY09_RS14450	COG0840	transmembrane signaling receptor activity
HPY09_RS14455	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPY09_RS14460	COG5380	lipid catabolic process
HPY09_RS14485	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_RS14490	COG4605	iron ion homeostasis
HPY09_RS14495	COG4604	ABC transporter, ATP-binding protein
HPY09_RS14500	COG2207	Transcriptional regulator
HPY09_RS14515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPY09_RS14520	COG0640	Transcriptional regulator
HPY09_RS14525	COG0798	PFAM Bile acid sodium symporter
HPY09_RS14545	COG0583	DNA-binding transcription factor activity
HPY09_RS14560	COG0745	RESPONSE REGULATOR receiver
HPY09_RS14590	COG3623	hexulose-6-phosphate isomerase
HPY09_RS14595	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPY09_RS14600	COG0561	phosphatase activity
HPY09_RS14645	COG1335	isochorismatase
HPY09_RS14650	COG1741	Belongs to the pirin family
HPY09_RS14655	COG0583	DNA-binding transcription factor activity
HPY09_RS14660	COG0366	Alpha amylase catalytic
HPY09_RS14680	COG0745	RESPONSE REGULATOR receiver
HPY09_RS14685	COG5002	protein histidine kinase activity
HPY09_RS14705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPY09_RS14720	COG0583	DNA-binding transcription factor activity
HPY09_RS14735	COG1686	Belongs to the peptidase S11 family
HPY09_RS14755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY09_RS14755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPY09_RS14760	COG0509	glycine decarboxylation via glycine cleavage system
HPY09_RS14765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPY09_RS14790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPY09_RS14795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPY09_RS14805	COG4977	sequence-specific DNA binding
HPY09_RS14875	COG0346	lactoylglutathione lyase activity
HPY09_RS14905	COG0384	phenazine biosynthesis protein PhzF
HPY09_RS14965	COG0384	phenazine biosynthesis protein PhzF
HPY09_RS14995	COG0456	acetyltransferase
HPY09_RS15025	COG0384	phenazine biosynthesis protein PhzF
HPY09_RS15170	COG2801	Transposase and inactivated derivatives
HPY09_RS15320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPY09_RS15455	COG0346	lactoylglutathione lyase activity
HPY09_RS15460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPY09_RS15505	COG0456	acetyltransferase
HPY09_RS15555	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPY09_RS15765	COG3041	Addiction module toxin RelE StbE family
HPY09_RS15825	COG1418	mRNA catabolic process
HPY09_RS15850	COG0456	acetyltransferase
HPY09_RS15865	COG3549	Plasmid maintenance system killer
HPY09_RS15870	COG3093	addiction module antidote protein HigA
HPY09_RS15930	COG0456	acetyltransferase
HPY09_RS15935	COG4977	sequence-specific DNA binding
HPY09_RS15965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_RS15965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPY09_RS16050	COG1714	RDD family
HPY09_RS16170	COG2357	RelA SpoT domain protein
HPY09_RS16470	COG0346	lactoylglutathione lyase activity
HPY09_RS16545	COG5642	Protein of unknown function (DUF2384)
HPY09_RS16565	COG0545	Peptidyl-prolyl cis-trans isomerase
HPY09_RS16575	COG0840	transmembrane signaling receptor activity
HPY09_RS16580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY09_RS16585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_RS16590	COG1621	beta-fructofuranosidase activity
HPY09_RS16600	COG1263	PTS System
HPY09_RS16600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPY09_RS16640	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPY09_RS16680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPY09_RS16685	COG0583	DNA-binding transcription factor activity
HPY09_RS16710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPY09_RS16735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPY09_RS16745	COG2390	Transcriptional regulator
HPY09_RS16750	COG2897	thiosulfate sulfurtransferase activity
HPY09_RS16760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPY09_RS16770	COG0302	gtp cyclohydrolase
HPY09_RS16775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_RS16775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPY09_RS16780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HPY09_RS16785	COG1970	mechanosensitive ion channel activity
HPY09_RS16790	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPY09_RS16805	COG1011	Hydrolase
HPY09_RS16810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPY09_RS16815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY09_RS16825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPY09_RS16830	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY09_RS16835	COG3842	ATPase activity
HPY09_RS16855	COG3104	oligopeptide transport
HPY09_RS16880	COG4166	transmembrane transport
HPY09_RS16885	COG4174	ABC transporter (Permease)
HPY09_RS16890	COG4239	(ABC) transporter, permease
HPY09_RS16895	COG4172	Belongs to the ABC transporter superfamily
HPY09_RS16900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPY09_RS16915	COG0625	glutathione transferase activity
HPY09_RS16935	COG2050	protein possibly involved in aromatic compounds catabolism
HPY09_RS16950	COG4771	TonB-dependent receptor
HPY09_RS16955	COG0583	DNA-binding transcription factor activity
HPY09_RS16960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_RS16960	COG0045	succinate-CoA ligase (ADP-forming) activity
HPY09_RS16960	COG1042	CoA-binding domain protein
HPY09_RS16980	COG0023	Translation Initiation Factor
HPY09_RS16985	COG3140	Belongs to the UPF0181 family
HPY09_RS17000	COG0745	RESPONSE REGULATOR receiver
HPY09_RS17010	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPY09_RS17015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPY09_RS17030	COG3706	GGDEF domain
HPY09_RS17080	COG2824	Alkylphosphonate utilization operon protein PhnA
HPY09_RS17095	COG0737	Belongs to the 5'-nucleotidase family
HPY09_RS17100	COG3593	DNA synthesis involved in DNA repair
HPY09_RS17110	COG0583	DNA-binding transcription factor activity
HPY09_RS17115	COG2116	formate transmembrane transporter activity
HPY09_RS17125	COG3038	cytochrome b561
HPY09_RS17135	COG2200	EAL domain
HPY09_RS17150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPY09_RS17160	COG2205	protein histidine kinase activity
HPY09_RS17165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPY09_RS17165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPY09_RS17165	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPY09_RS17165	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPY09_RS17170	COG3158	transport of potassium into the cell
HPY09_RS17180	COG0523	cobalamin synthesis protein
HPY09_RS17185	COG0038	chloride channel
HPY09_RS17195	COG0156	8-amino-7-oxononanoate synthase activity
HPY09_RS17200	COG2205	protein histidine kinase activity
HPY09_RS17200	COG0784	Response regulator, receiver
HPY09_RS17205	COG0419	ATPase involved in DNA repair
HPY09_RS17210	COG0420	3'-5' exonuclease activity
HPY09_RS17215	COG1609	Transcriptional regulator
HPY09_RS17220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_RS17220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_RS17225	COG1105	Belongs to the carbohydrate kinase PfkB family
HPY09_RS17230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_RS17230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPY09_RS17230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPY09_RS17235	COG0189	ligase activity
HPY09_RS17235	COG4067	protein conserved in archaea
HPY09_RS17245	COG0602	queuosine metabolic process
HPY09_RS17250	COG1328	CTP reductase activity
HPY09_RS17260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPY09_RS17265	COG0840	transmembrane signaling receptor activity
HPY09_RS17270	COG3069	C4-dicarboxylate transmembrane transporter activity
HPY09_RS17275	COG1760	l-serine dehydratase
HPY09_RS17280	COG2197	response regulator
HPY09_RS17285	COG3850	Histidine kinase
HPY09_RS17290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPY09_RS17300	COG0243	molybdopterin cofactor binding
HPY09_RS17320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY09_RS17325	COG2197	response regulator
HPY09_RS17330	COG3851	Histidine kinase
HPY09_RS17335	COG2271	Major facilitator Superfamily
HPY09_RS17340	COG1840	ABC-type Fe3 transport system, periplasmic component
HPY09_RS17350	COG3842	ATPase activity
HPY09_RS17355	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPY09_RS17365	COG0183	Belongs to the thiolase family
HPY09_RS17375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_RS17380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPY09_RS17395	COG3706	GGDEF domain
HPY09_RS17400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPY09_RS17410	COG1979	alcohol dehydrogenase
HPY09_RS17425	COG4191	Histidine kinase
HPY09_RS17435	COG2271	Major facilitator Superfamily
HPY09_RS17440	COG0469	pyruvate kinase activity
HPY09_RS17450	COG1879	ABC-type sugar transport system periplasmic component
HPY09_RS17455	COG1803	Methylglyoxal synthase
HPY09_RS17460	COG1335	isochorismatase
HPY09_RS17465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPY09_RS17470	COG0210	DNA helicase
HPY09_RS17475	COG1289	transmembrane transporter activity
HPY09_RS17505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HPY09_RS17510	COG4149	molybdate abc transporter
HPY09_RS17515	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPY09_RS17520	COG1492	cobalamin metabolic process
HPY09_RS17560	COG1917	Cupin 2, conserved barrel domain protein
HPY09_RS17560	COG4977	sequence-specific DNA binding
HPY09_RS17565	COG4771	TonB-dependent receptor
HPY09_RS17570	COG2814	Major facilitator Superfamily
HPY09_RS17575	COG2226	methyltransferase
HPY09_RS17575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPY09_RS17575	COG3433	isochorismatase activity
HPY09_RS17600	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPY09_RS17605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPY09_RS17625	COG1132	(ABC) transporter
HPY09_RS17630	COG1132	(ABC) transporter
HPY09_RS17640	COG5002	protein histidine kinase activity
HPY09_RS17640	COG0784	Response regulator, receiver
HPY09_RS17645	COG1879	ABC-type sugar transport system periplasmic component
HPY09_RS17655	COG2827	Endonuclease containing a URI domain
HPY09_RS17670	COG2926	Belongs to the UPF0265 family
HPY09_RS17685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPY09_RS17690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPY09_RS17700	COG0247	lactate metabolic process
HPY09_RS17705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPY09_RS17710	COG3118	belongs to the thioredoxin family
HPY09_RS17735	COG4160	amino acid transport
HPY09_RS17740	COG4215	(ABC) transporter
HPY09_RS17745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_RS17750	COG1126	abc transporter atp-binding protein
HPY09_RS17760	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPY09_RS17770	COG0494	nUDIX hydrolase
HPY09_RS17775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPY09_RS17785	COG1309	transcriptional regulator
HPY09_RS17790	COG0513	Belongs to the DEAD box helicase family
HPY09_RS17795	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HPY09_RS17800	COG0814	amino acid
HPY09_RS17805	COG0840	transmembrane signaling receptor activity
HPY09_RS17810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPY09_RS17815	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPY09_RS17825	COG1984	allophanate hydrolase subunit 2
HPY09_RS17840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPY09_RS17845	COG4181	ATPase activity
HPY09_RS17855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPY09_RS17860	COG5001	Diguanylate cyclase
HPY09_RS17860	COG1716	ATPase activity
HPY09_RS17870	COG0484	heat shock protein binding
HPY09_RS17885	COG0546	phosphoglycolate phosphatase activity
HPY09_RS17900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPY09_RS17905	COG1368	sulfuric ester hydrolase activity
HPY09_RS17915	COG0513	Belongs to the DEAD box helicase family
HPY09_RS17930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPY09_RS17940	COG3046	protein related to deoxyribodipyrimidine photolyase
HPY09_RS17945	COG3397	chitin binding
HPY09_RS17950	COG3227	Zinc metalloprotease (Elastase)
HPY09_RS17960	COG0010	Belongs to the arginase family
HPY09_RS17965	COG1166	arginine decarboxylase activity
HPY09_RS17975	COG2239	Acts as a magnesium transporter
HPY09_RS17980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPY09_RS17985	COG0459	protein refolding
HPY09_RS17995	COG0527	aspartate kinase activity
HPY09_RS18000	COG0662	Cupin 2, conserved barrel domain protein
HPY09_RS18005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPY09_RS18010	COG0456	acetyltransferase
HPY09_RS18015	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPY09_RS18020	COG3186	Phenylalanine-4-hydroxylase
HPY09_RS18025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPY09_RS18040	COG2264	protein methyltransferase activity
HPY09_RS18065	COG1253	flavin adenine dinucleotide binding
HPY09_RS18070	COG1765	OsmC-like protein
HPY09_RS18100	COG1252	NADH dehydrogenase
HPY09_RS18105	COG0531	amino acid
HPY09_RS18110	COG3706	GGDEF domain
HPY09_RS18120	COG3279	Response regulator of the LytR AlgR family
HPY09_RS18125	COG3275	phosphorelay sensor kinase activity
HPY09_RS18140	COG0577	efflux transmembrane transporter activity
HPY09_RS18140	COG1136	(ABC) transporter
HPY09_RS18145	COG1136	(ABC) transporter
HPY09_RS18155	COG4989	oxidoreductase activity
HPY09_RS18160	COG0366	Alpha amylase catalytic
HPY09_RS18170	COG2067	long-chain fatty acid transport protein
HPY09_RS18175	COG2267	carboxylic ester hydrolase activity
HPY09_RS18185	COG3227	Zinc metalloprotease (Elastase)
HPY09_RS18190	COG3047	cAMP biosynthetic process
HPY09_RS18200	COG1686	Belongs to the peptidase S11 family
HPY09_RS18210	COG1278	Cold shock
HPY09_RS18220	COG3048	D-serine ammonia-lyase activity
HPY09_RS18250	COG2801	Transposase and inactivated derivatives
HPY09_RS18255	COG5002	protein histidine kinase activity
HPY09_RS18280	COG0582	viral genome integration into host DNA
HPY09_RS18300	COG1063	alcohol dehydrogenase
HPY09_RS18325	COG0346	lactoylglutathione lyase activity
HPY09_RS18345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPY09_RS18350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY09_RS18355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPY09_RS18365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPY09_RS18390	COG1929	Belongs to the glycerate kinase type-1 family
HPY09_RS18395	COG2610	gluconate transmembrane transporter activity
HPY09_RS18400	COG3835	regulator
HPY09_RS18410	COG0748	coenzyme F420 binding
HPY09_RS18415	COG3721	Heme iron utilization protein
HPY09_RS18425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HPY09_RS18430	COG0811	peptide transport
HPY09_RS18435	COG0848	biopolymer transport protein
HPY09_RS18440	COG4558	Periplasmic binding protein
HPY09_RS18445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPY09_RS18450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPY09_RS18485	COG0633	Ferredoxin
HPY09_RS18485	COG0633	Ferredoxin
HPY09_RS18485	COG3217	Mosc domain protein beta barrel domain protein
HPY09_RS18485	COG3217	Mosc domain protein beta barrel domain protein
HPY09_RS18490	COG0418	dihydroorotase activity
HPY09_RS18495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPY09_RS18500	COG2354	Protein conserved in bacteria
HPY09_RS18510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPY09_RS18515	COG1278	Cold shock
HPY09_RS18540	COG3706	GGDEF domain
HPY09_RS18545	COG1349	DNA-binding transcription factor activity
HPY09_RS18560	COG3833	ABC-type maltose transport systems, permease component
HPY09_RS18565	COG1175	transmembrane transport
HPY09_RS18575	COG3842	ATPase activity
HPY09_RS18580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPY09_RS18595	COG0393	Putative heavy-metal-binding
HPY09_RS18605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPY09_RS18610	COG0835	chemotaxis
HPY09_RS18610	COG0784	Response regulator, receiver
HPY09_RS18615	COG1846	Transcriptional regulator
HPY09_RS18620	COG3706	GGDEF domain
HPY09_RS18655	COG0583	DNA-binding transcription factor activity
HPY09_RS18660	COG5001	Diguanylate cyclase
HPY09_RS18670	COG1741	Belongs to the pirin family
HPY09_RS18675	COG3123	guanosine phosphorylase activity
HPY09_RS18685	COG2211	Major facilitator Superfamily
HPY09_RS18695	COG1067	ATP-dependent peptidase activity
HPY09_RS18705	COG4172	Belongs to the ABC transporter superfamily
HPY09_RS18725	COG0583	DNA-binding transcription factor activity
HPY09_RS18735	COG1620	l-lactate permease
HPY09_RS18750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HPY09_RS18760	COG0840	transmembrane signaling receptor activity
HPY09_RS18780	COG2258	MOSC domain
HPY09_RS18785	COG0513	Belongs to the DEAD box helicase family
HPY09_RS18795	COG1132	(ABC) transporter
HPY09_RS18805	COG1902	pentaerythritol trinitrate reductase activity
HPY09_RS18815	COG1280	lysine exporter protein (LysE YggA)
HPY09_RS18820	COG2207	Transcriptional regulator
HPY09_RS18840	COG1846	Transcriptional regulator
HPY09_RS18845	COG1764	response to oxidative stress
HPY09_RS18850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPY09_RS18855	COG0697	spore germination
HPY09_RS18865	COG0700	Nucleoside recognition
HPY09_RS18870	COG3366	ferrous iron transmembrane transporter activity
HPY09_RS18875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPY09_RS18885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPY09_RS18890	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPY09_RS18895	COG2259	Doxx family
HPY09_RS18920	COG0363	glucosamine-6-phosphate deaminase activity
HPY09_RS18935	COG4580	involved in the transport of maltose and maltodextrins
HPY09_RS18950	COG0840	transmembrane signaling receptor activity
HPY09_RS18965	COG0840	transmembrane signaling receptor activity
HPY09_RS18970	COG5001	Diguanylate cyclase
HPY09_RS18980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPY09_RS18985	COG1126	abc transporter atp-binding protein
HPY09_RS18995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPY09_RS19000	COG4597	amino acid ABC transporter
HPY09_RS19005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPY09_RS19010	COG2213	PTS system mannitol-specific
HPY09_RS19010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPY09_RS19015	COG0246	Mannitol dehydrogenase
HPY09_RS19020	COG3722	fumarate hydratase activity
HPY09_RS19025	COG0673	inositol 2-dehydrogenase activity
HPY09_RS19055	COG2910	NAD(P)H-binding
HPY09_RS19065	COG0840	transmembrane signaling receptor activity
HPY09_RS19070	COG4221	oxidoreductase activity
HPY09_RS19080	COG1901	pseudouridine methyltransferase
HPY09_RS19095	COG0531	amino acid
HPY09_RS19100	COG1982	Orn Lys Arg decarboxylase major
HPY09_RS19110	COG2197	response regulator
HPY09_RS19150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPY09_RS19175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPY09_RS19240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPY09_RS19245	COG0840	transmembrane signaling receptor activity
HPY09_RS19250	COG0835	chemotaxis
HPY09_RS19255	COG0835	chemotaxis
HPY09_RS19260	COG2198	Histidine kinase
HPY09_RS19260	COG0643	Histidine kinase
HPY09_RS19275	COG0747	negative chemotaxis
HPY09_RS19280	COG0601	transmembrane transport
HPY09_RS19285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPY09_RS19290	COG4608	Belongs to the ABC transporter superfamily
HPY09_RS19295	COG2194	sulfuric ester hydrolase activity
HPY09_RS19300	COG0642	Histidine kinase
HPY09_RS19305	COG0745	RESPONSE REGULATOR receiver
HPY09_RS19315	COG4221	oxidoreductase activity
HPY09_RS19335	COG1444	tRNA N-acetyltransferase activity
HPY09_RS19340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPY09_RS19450	COG0653	protein targeting
HPY09_RS19480	COG0776	regulation of translation
HPY09_RS19595	COG0754	glutathionylspermidine amidase activity
HPY09_RS19615	COG1842	Phage shock protein A
HPY09_RS19650	COG2026	Addiction module toxin, RelE StbE family
HPY09_RS19785	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPY09_RS19905	COG3300	MHYT domain
HPY09_RS19905	COG5001	Diguanylate cyclase
HPY09_RS20260	COG1199	ATP-dependent helicase activity
HPY09_RS20300	COG0210	DNA helicase
HPY09_RS20350	COG4206	TonB-dependent receptor
HPY09_RS20430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPY09_RS20500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPY09_RS20515	COG0681	Belongs to the peptidase S26 family
HPY09_RS20540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPY09_RS20645	COG1475	DNA binding
HPY09_RS20895	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates