locus-tag class description GPY24_RS00015 ENOG4108NVR Methyl-accepting chemotaxis GPY24_RS00020 ENOG4107S17 Phosphate-binding protein GPY24_RS00030 ENOG4105E2Z phosphate ABC transporter (Permease GPY24_RS00050 ENOG4107QVM von Willebrand factor, type A GPY24_RS00070 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GPY24_RS00075 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS00085 ENOG4108IJ9 (ABC) transporter GPY24_RS00090 ENOG4107FKK extracellular solute-binding protein family 1 GPY24_RS00095 ENOG4105D56 permease protein GPY24_RS00100 ENOG4105EG2 ABC transporter, permease GPY24_RS00120 ENOG4105EQD regulatoR GPY24_RS00130 ENOG4105CKW Inner membrane protein yedI GPY24_RS00135 ENOG4105BZU Histidine kinase GPY24_RS00145 ENOG4105QVC MOSC domain-containing protein GPY24_RS00145 ENOG4105QVC MOSC domain-containing protein GPY24_RS00150 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GPY24_RS00190 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GPY24_RS00195 ENOG4105EHG Permease protein GPY24_RS00205 ENOG4106GFD transport protein GPY24_RS00210 ENOG41090AP transport protein GPY24_RS00220 ENOG4105D4P Coproporphyrinogen iii oxidase GPY24_RS00225 ENOG41090JE Utilization Protein GPY24_RS00230 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related GPY24_RS00245 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GPY24_RS00275 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS00280 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS00285 ENOG4105DWD nucleoside recognition domain protein GPY24_RS00310 ENOG4105CR8 Transcriptional regulator GPY24_RS00315 ENOG4105E5M Multidrug resistance protein D GPY24_RS00325 ENOG4105VW4 glutaredoxin 3 GPY24_RS00330 ENOG4108SXK Transporter Drug Metabolite Exporter family GPY24_RS00340 ENOG4108ZHJ Organic hydroperoxide resistance protein GPY24_RS00345 ENOG4105K56 Transcriptional regulator GPY24_RS00385 ENOG4105UYK outer membrane protein a GPY24_RS00395 ENOG4105CVA phosphate GPY24_RS00415 ENOG4105C1J atp-dependent rna helicase GPY24_RS00430 ENOG4108JCI Transcriptional regulator GPY24_RS00435 ENOG4105DKK Benzoate GPY24_RS00460 ENOG4108IJ7 Glycine betaine GPY24_RS00465 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GPY24_RS00475 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GPY24_RS00490 ENOG4108IJ7 Glycine betaine GPY24_RS00495 ENOG4105CA0 peroxidase GPY24_RS00505 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GPY24_RS00530 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GPY24_RS00545 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY24_RS00555 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GPY24_RS00585 ENOG4105EKQ RNA-directed DNA polymerase GPY24_RS00600 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY24_RS00605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY24_RS00610 ENOG4105MIR Phenylalanine 4-monooxygenase GPY24_RS00615 ENOG41090A4 Pterin carbinolamine dehydratase GPY24_RS00630 ENOG4105C44 Serine transporter GPY24_RS00655 ENOG4105D65 subunit l GPY24_RS00665 ENOG4105CUB amino acid GPY24_RS00680 ENOG4108K3Z AraC family transcriptional regulator GPY24_RS00695 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GPY24_RS00700 ENOG4108WUH Transcriptional regulator, TetR family GPY24_RS00735 ENOG4105CM4 permease protein GPY24_RS00740 ENOG4108IPW abc transporter atp-binding protein GPY24_RS00745 ENOG4108Z6Z Transcriptional regulator GPY24_RS00750 ENOG4108W3Q Transcriptional regulator GPY24_RS00785 ENOG4105EM2 membrane GPY24_RS00795 ENOG4108Z5K methylglyoxal synthase GPY24_RS00800 ENOG4108Z5K methylglyoxal synthase GPY24_RS00805 ENOG4108SV3 Tmao reductase system periplasmic protein tort GPY24_RS00810 ENOG4105BZU Histidine kinase GPY24_RS00815 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GPY24_RS00830 ENOG4105E6M Sulphatase-modifying factor protein GPY24_RS00870 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS00880 ENOG4105WJG Glutathione GPY24_RS00910 ENOG4105UYK outer membrane protein a GPY24_RS00950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY24_RS00955 ENOG4108JQ5 ABC transporter GPY24_RS00980 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS01000 ENOG4105BZU Histidine kinase GPY24_RS01020 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS01060 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY24_RS01065 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS01075 ENOG4105VXR cytoplasmic protein GPY24_RS01085 ENOG4105ECQ AraC Family Transcriptional Regulator GPY24_RS01090 ENOG4108ISG Major Facilitator GPY24_RS01095 ENOG4105K63 Thioredoxin GPY24_RS01145 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GPY24_RS01150 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GPY24_RS01155 ENOG4105CGF Aromatic amino acid aminotransferase GPY24_RS01160 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY24_RS01175 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GPY24_RS01180 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GPY24_RS01185 ENOG4105E0C molybdate abc transporter GPY24_RS01190 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GPY24_RS01200 ENOG4105BZU Histidine kinase GPY24_RS01225 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY24_RS01235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY24_RS01255 ENOG4108ZJT translation initiation factor, Sui1 GPY24_RS01270 ENOG4105CPF Cell wall formation (By similarity) GPY24_RS01280 ENOG4105CD5 CoA-binding domain protein GPY24_RS01295 ENOG4105BZU Histidine kinase GPY24_RS01310 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GPY24_RS01335 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GPY24_RS01345 ENOG4108I0Y (ABC) transporter GPY24_RS01385 ENOG4105VF7 tolerance protein GPY24_RS01395 ENOG4105CG3 alpha amylase, catalytic region GPY24_RS01400 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GPY24_RS01410 ENOG4105KA0 thioesterase Superfamily protein GPY24_RS01465 ENOG4108UQ5 membrane protein YcdZ GPY24_RS01470 ENOG4105DUM transcriptional regulator, lysR family GPY24_RS01475 ENOG4105TMB Formate nitrite transporter GPY24_RS01480 ENOG4108YYC ycei family GPY24_RS01485 ENOG4105DS1 cytochrome b561 GPY24_RS01500 ENOG4105C1J atp-dependent rna helicase GPY24_RS01505 ENOG4108ZYK Acyl carrier protein phosphodiesterase GPY24_RS01510 ENOG4108N3W hemolysin secretion protein GPY24_RS01515 ENOG4107XGZ Hydrolase GPY24_RS01530 ENOG4107RE1 Inosine-guanosine kinase GPY24_RS01550 ENOG4105CF7 AraC family transcriptional regulator GPY24_RS01575 ENOG4107B7Y DNA-binding transcriptional regulator FruR GPY24_RS01580 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GPY24_RS01585 ENOG4105DE4 1-phosphofructokinase GPY24_RS01590 ENOG4105DM4 PTS System GPY24_RS01640 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GPY24_RS01665 ENOG4107SDU Methyl-accepting chemotaxis GPY24_RS01670 ENOG4105EYH Exonuclease GPY24_RS01680 ENOG4105BZU Histidine kinase GPY24_RS01700 ENOG4108MGY Histidine kinase GPY24_RS01705 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GPY24_RS01715 ENOG4107R88 Chemotaxis protein (CheV) GPY24_RS01720 ENOG4105ETE Transcriptional regulator (LacI family GPY24_RS01725 ENOG4108RVA ribokinase GPY24_RS01730 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPY24_RS01735 ENOG4105CNN ABC, transporter GPY24_RS01740 ENOG4105C2J ABC transporter GPY24_RS01760 ENOG4105MSB protein, conserved in bacteria GPY24_RS01770 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) GPY24_RS01800 ENOG4106TNF Periplasmic binding protein GPY24_RS01830 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPY24_RS01845 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS01865 ENOG4105CXY transporter GPY24_RS01870 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPY24_RS01890 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein GPY24_RS01895 ENOG4105ECQ AraC Family Transcriptional Regulator GPY24_RS01905 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GPY24_RS01955 ENOG4108JQ7 (ABC) transporter GPY24_RS01960 ENOG4105C3U ABC transporter GPY24_RS01965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY24_RS01990 ENOG4108WAV Transcriptional regulator GPY24_RS02000 ENOG4105BZU Histidine kinase GPY24_RS02005 ENOG4108N3W hemolysin secretion protein GPY24_RS02020 ENOG4105VEQ Cold shock protein GPY24_RS02050 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY24_RS02055 ENOG4107VXZ Hydrolase GPY24_RS02060 ENOG4108YZN class I peptide chain release factor GPY24_RS02065 ENOG4108N3W hemolysin secretion protein GPY24_RS02070 ENOG4107YWA deoxycytidylate deaminase GPY24_RS02085 ENOG4107RGM aldo keto reductase GPY24_RS02100 ENOG4105CMQ Chloride channel GPY24_RS02110 ENOG4105EUJ GTP cyclohydrolase i GPY24_RS02115 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY24_RS02120 ENOG4105D06 uba thif-type nad fad binding protein GPY24_RS02125 ENOG4105KHC sulfurtransferase GPY24_RS02145 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPY24_RS02185 ENOG4105BZU Histidine kinase GPY24_RS02190 ENOG4107Z5C methylesterase GPY24_RS02195 ENOG4105BZU Histidine kinase GPY24_RS02210 ENOG4105C1J atp-dependent rna helicase GPY24_RS02215 ENOG4105CKI cobalamin synthesis protein GPY24_RS02225 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY24_RS02250 ENOG4105W1N transcriptional regulator GPY24_RS02365 ENOG4105VRT cytoplasmic protein GPY24_RS02390 ENOG4105R8A Heat shock protein GPY24_RS02410 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY24_RS02430 ENOG4105CPP Dehydrogenase, E1 component GPY24_RS02435 ENOG4107QSN dihydrolipoamide acetyltransferase GPY24_RS02440 ENOG4105C10 Electron transfer flavoprotein GPY24_RS02445 ENOG4105BZJ Electron transfer flavoprotein GPY24_RS02450 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPY24_RS02455 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GPY24_RS02465 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter GPY24_RS02475 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY24_RS02480 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY24_RS02485 ENOG4105EJC lysr family transcriptional regulator GPY24_RS02495 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS02515 ENOG4105F04 LysR family Transcriptional regulator GPY24_RS02520 ENOG4108HKT sucrose-6-phosphate hydrolase GPY24_RS02525 ENOG4107FKK extracellular solute-binding protein family 1 GPY24_RS02530 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY24_RS02540 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GPY24_RS02550 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY24_RS02560 ENOG4105WH1 Two component transcriptional regulator luxr family GPY24_RS02610 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GPY24_RS02620 ENOG4105CHU acetyl-coa acetyltransferase GPY24_RS02630 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY24_RS02655 ENOG4108XM1 transcriptional regulator AsnC family GPY24_RS02670 ENOG4105BZU Histidine kinase GPY24_RS02685 ENOG41082IR Excinuclease ABC C subunit domain protein GPY24_RS02700 ENOG41090HJ UPF0265 protein GPY24_RS02730 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPY24_RS02755 ENOG4105DVH amino acid GPY24_RS02775 ENOG4105CJW magnesium transporter GPY24_RS02790 ENOG4105D64 Mechanosensitive ion channel GPY24_RS02880 ENOG4108TEM pseudouridine methyltransferase GPY24_RS02890 ENOG4105EYK Phosphatidylglycerophosphatase B GPY24_RS02905 ENOG4108HCJ Hydrolase GPY24_RS02920 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GPY24_RS02925 ENOG4107SJ9 decarboxylase GPY24_RS02935 ENOG4105JQN Transcriptional regulator GPY24_RS02940 ENOG4108RYK Nad-dependent epimerase dehydratase GPY24_RS02945 ENOG4107EXC regulatoR GPY24_RS02955 ENOG41080IJ Diacylglycerol kinase GPY24_RS02960 ENOG4105DIJ Phosphoethanolamine transferase GPY24_RS02975 ENOG4108K8S endonuclease I GPY24_RS02990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY24_RS03015 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GPY24_RS03025 ENOG4108R86 Transcriptional regulator GPY24_RS03045 ENOG4105CK2 sodium dicarboxylate symporter GPY24_RS03060 ENOG4108W2Y isochorismatase GPY24_RS03065 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) GPY24_RS03185 ENOG4105CNH Multidrug resistance protein MdtL GPY24_RS03190 ENOG4105G2Y Transcriptional regulator GPY24_RS03200 ENOG4105KXC Collagenase GPY24_RS03205 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) GPY24_RS03210 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY24_RS03220 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) GPY24_RS03230 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY24_RS03235 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY24_RS03260 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GPY24_RS03265 ENOG4105ECQ AraC Family Transcriptional Regulator GPY24_RS03275 ENOG4105VEQ Cold shock protein GPY24_RS03305 ENOG4105MUN Divergent AAA domain GPY24_RS03320 ENOG4105CPQ Dehydrogenase GPY24_RS03325 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY24_RS03335 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY24_RS03345 ENOG4105E5W Transporter GPY24_RS03375 ENOG4105DHT Metal Dependent Phosphohydrolase GPY24_RS03395 ENOG4107RUE extracellular solute-binding protein family 1 GPY24_RS03405 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GPY24_RS03425 ENOG4108YYI Protein of unknown function (DUF2810) GPY24_RS03430 ENOG4105D9N nucleoside GPY24_RS03445 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS03450 ENOG4108VYJ response regulator receiver protein GPY24_RS03460 ENOG4105CBS Chea signal transduction histidine kinase GPY24_RS03465 ENOG4108V3W Chemotaxis protein, CheW GPY24_RS03475 ENOG4108V3W Chemotaxis protein, CheW GPY24_RS03480 ENOG4105BZU Histidine kinase GPY24_RS03485 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GPY24_RS03490 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY24_RS03505 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GPY24_RS03515 ENOG41086CX Inherit from COG: 40-residue yvtn family beta-propeller repeat protein GPY24_RS03525 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GPY24_RS03545 ENOG4106KNT transcriptional regulator GPY24_RS03560 ENOG4105CJ1 ABC, transporter GPY24_RS03590 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY24_RS03605 ENOG4105C1J atp-dependent rna helicase GPY24_RS03620 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS03630 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GPY24_RS03660 ENOG4105WH1 Two component transcriptional regulator luxr family GPY24_RS03670 ENOG41090KN UPF0303 protein GPY24_RS03680 ENOG4105E98 transcriptional regulator DeoR family GPY24_RS03685 ENOG4107T9C Alpha amylase catalytic region GPY24_RS03695 ENOG4105C2I pirin domain protein GPY24_RS03700 ENOG4105MZU cell filamentation protein GPY24_RS03710 ENOG4108594 Permease of the drug metabolite transporter GPY24_RS03715 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY24_RS03725 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY24_RS03730 ENOG4105BZU Histidine kinase GPY24_RS03815 ENOG4105JQN Transcriptional regulator GPY24_RS03820 ENOG4105C1J atp-dependent rna helicase GPY24_RS03840 ENOG4105BZU Histidine kinase GPY24_RS03845 ENOG4105BZU Histidine kinase GPY24_RS03855 ENOG4105BZU Histidine kinase GPY24_RS03910 ENOG4107YU2 histidine triad (hIT) protein GPY24_RS03925 ENOG4108M21 GPY24_RS03935 ENOG41080QX K07048 phosphotriesterase-related protein GPY24_RS03940 ENOG4105MUZ Protein of unknown function DUF2620 GPY24_RS03945 ENOG4106M0N transport system permease protein GPY24_RS03955 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GPY24_RS03965 ENOG4105BZ1 (ABC) transporter GPY24_RS03985 ENOG4107FKK extracellular solute-binding protein family 1 GPY24_RS04000 ENOG4107W52 maltose operon periplasmic protein GPY24_RS04005 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GPY24_RS04015 ENOG4108K0B C-di-gmp phosphodiesterase GPY24_RS04025 ENOG4105EUB pirin domain protein GPY24_RS04030 ENOG4105NBK UPF0345 protein GPY24_RS04055 ENOG4105DN9 Na H antiporter GPY24_RS04095 ENOG4105D7Z glutathione synthase GPY24_RS04110 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GPY24_RS04120 ENOG4105D6U Sodium Glutamate Symporter GPY24_RS04125 ENOG4105D6U Sodium Glutamate Symporter GPY24_RS04130 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS04135 ENOG4108VAC response regulator GPY24_RS04140 ENOG4108HRK Histidine kinase GPY24_RS04190 ENOG4105D4Y metalloprotease GPY24_RS04210 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GPY24_RS04220 ENOG4105C8N cysteinyl-tRNA synthetase GPY24_RS04225 ENOG4108JJA ABC, transporter GPY24_RS04240 ENOG4107QZV Type I secretion membrane fusion protein GPY24_RS04245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY24_RS04250 ENOG4105CQZ Histidine kinase GPY24_RS04255 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GPY24_RS04270 ENOG4105C26 Dehydrogenase GPY24_RS04280 ENOG4105CK7 Sodium proline symporter GPY24_RS04290 ENOG4105EW9 transcriptional regulator AsnC family GPY24_RS04320 ENOG4105E93 esterase GPY24_RS04325 ENOG4105D05 Receptor GPY24_RS04355 ENOG4105EG2 ABC transporter, permease GPY24_RS04365 ENOG4107FKK extracellular solute-binding protein family 1 GPY24_RS04375 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY24_RS04385 ENOG4108IJ9 (ABC) transporter GPY24_RS04410 ENOG4105CKT filamentous hemagglutinin GPY24_RS04420 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GPY24_RS04425 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GPY24_RS04445 ENOG4105EW9 transcriptional regulator AsnC family GPY24_RS04480 ENOG4105UEI Transcriptional Regulator AraC Family GPY24_RS04490 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GPY24_RS04495 ENOG4105CBN LysR family transcriptional regulator GPY24_RS04500 ENOG4105D7K pfkb domain protein GPY24_RS04510 ENOG4108HKT sucrose-6-phosphate hydrolase GPY24_RS04520 ENOG4105C5Y PTS System GPY24_RS04525 ENOG4108RNG Permease of the drug metabolite transporter GPY24_RS04550 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY24_RS04555 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY24_RS04560 ENOG4105HEI LysR family (Transcriptional regulator GPY24_RS04565 ENOG4105F27 Major Facilitator GPY24_RS04585 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY24_RS04600 ENOG4105D5U fad dependent oxidoreductase GPY24_RS04605 ENOG4107W31 Pentapeptide repeat protein GPY24_RS04610 ENOG4105EIF outer membrane protein W GPY24_RS04635 ENOG4105CYM Glutathione S-transferase GPY24_RS04640 ENOG4105DHT Metal Dependent Phosphohydrolase GPY24_RS04645 ENOG4105EAM Na Pi-cotransporter GPY24_RS04655 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS04665 ENOG4105C0F tryptophanase EC 4.1.99.1 GPY24_RS04675 ENOG4108RCM Nitroreductase GPY24_RS04685 ENOG4105EJC lysr family transcriptional regulator GPY24_RS04695 ENOG4105DP0 ferredoxin-NADP reductase GPY24_RS04715 ENOG4105RA2 Membrane GPY24_RS04745 ENOG4108HK0 -acetyltransferase GPY24_RS04750 ENOG4108JP0 extracellular solute-binding protein family 1 GPY24_RS04755 ENOG4105GR3 Histidine kinase GPY24_RS04760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY24_RS04775 ENOG4108Z4X TRANSCRIPTIONal GPY24_RS04780 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GPY24_RS04795 ENOG4108V1U phospholipid-binding protein GPY24_RS04825 ENOG4105C5H ABC transporter GPY24_RS04830 ENOG4105Q26 Siderophore-interacting protein GPY24_RS04840 ENOG4108Z4U Ferredoxin GPY24_RS04865 ENOG4105VNT transposase (IS4 family) protein GPY24_RS04905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY24_RS04935 ENOG4105BZU Histidine kinase GPY24_RS04950 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY24_RS04955 ENOG4105BZU Histidine kinase GPY24_RS04960 ENOG4105BZU Histidine kinase GPY24_RS04970 ENOG4105BZU Histidine kinase GPY24_RS04975 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY24_RS04980 ENOG4106S9K Transcriptional regulator GPY24_RS04985 ENOG4105BZU Histidine kinase GPY24_RS05005 ENOG4105BZU Histidine kinase GPY24_RS05035 ENOG4108UKZ OsmC family GPY24_RS05060 ENOG4105PAD Hydrolase GPY24_RS05065 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GPY24_RS05070 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY24_RS05075 ENOG410874W AraC family transcriptional regulator GPY24_RS05095 ENOG4105DUX Transporter GPY24_RS05100 ENOG4105EJQ L-serine dehydratase GPY24_RS05115 ENOG4105X58 receptor GPY24_RS05130 ENOG4105C37 (CBS) domain GPY24_RS05140 ENOG41080TA Multiple resistance and ph regulation protein f GPY24_RS05145 ENOG4105SC1 monovalent cation H antiporter subunit E GPY24_RS05150 ENOG4108JPZ Monovalent cation H antiporter subunit D GPY24_RS05160 ENOG4105D65 subunit l GPY24_RS05170 ENOG4105Q9Y Universal stress protein GPY24_RS05175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY24_RS05200 ENOG4105BZU Histidine kinase GPY24_RS05205 ENOG4108NVR Methyl-accepting chemotaxis GPY24_RS05220 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPY24_RS05235 ENOG4107QVI Methyltransferase, type 11 GPY24_RS05250 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY24_RS05275 ENOG4105E89 ABC transporter GPY24_RS05310 ENOG4106PMH Extracellular solute-binding protein family 3 GPY24_RS05315 ENOG4105E5Z arginine transporter ATP-binding subunit GPY24_RS05360 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GPY24_RS05375 ENOG4105DMF Dehydrogenase GPY24_RS05380 ENOG4105DAA L-lactate GPY24_RS05385 ENOG4105CC0 LysR family Transcriptional regulator GPY24_RS05405 ENOG4105DAN ATP-dependent protease GPY24_RS05410 ENOG4105YE1 PilZ domain GPY24_RS05420 ENOG4108MK9 spermidine N(1)-acetyltransferase GPY24_RS05435 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GPY24_RS05440 ENOG4106NZI LysR family Transcriptional regulator GPY24_RS05445 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GPY24_RS05455 ENOG4108JJB ABC transporter GPY24_RS05480 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY24_RS05490 ENOG4108XDN Transcriptional regulator GPY24_RS05500 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPY24_RS05745 ENOG4105C1J atp-dependent rna helicase GPY24_RS05755 ENOG4108MVK Receptor GPY24_RS05765 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GPY24_RS05770 ENOG4105HF0 Membrane GPY24_RS05780 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GPY24_RS05795 ENOG41063Z6 transcriptional regulator, lysR family GPY24_RS05800 ENOG41080HT Transcriptional regulator, arsr family GPY24_RS05805 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GPY24_RS05810 ENOG4105CJR Integral membrane protein (MviN GPY24_RS05815 ENOG4105DTN riboflavin biosynthesis protein ribF GPY24_RS05825 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GPY24_RS05830 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GPY24_RS05835 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GPY24_RS05840 ENOG4108NEV two component transcriptional regulator, LytTR family GPY24_RS05870 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GPY24_RS05875 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GPY24_RS05880 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY24_RS05905 ENOG4107SC1 transglycosylase GPY24_RS05910 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GPY24_RS05915 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY24_RS05925 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GPY24_RS05930 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GPY24_RS05935 ENOG4105C34 Pseudouridine synthase GPY24_RS05940 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GPY24_RS05945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY24_RS05990 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) GPY24_RS05995 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GPY24_RS06015 ENOG4105BZU Histidine kinase GPY24_RS06025 ENOG4105C9X ppx gppa phosphatase GPY24_RS06045 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY24_RS06060 ENOG4106N3A copper homeostasis protein cutc GPY24_RS06070 ENOG4105C5Q Transcriptional regulator GPY24_RS06075 ENOG4107QP3 malate synthase g GPY24_RS06080 ENOG4108I9X Isocitrate lyase GPY24_RS06085 ENOG4105W87 Cbs domain GPY24_RS06095 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GPY24_RS06100 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GPY24_RS06105 ENOG4105VIE preprotein translocase, subunit YajC GPY24_RS06120 ENOG4105ECY inositol monophosphatase GPY24_RS06125 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GPY24_RS06130 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GPY24_RS06135 ENOG4105C3J Cysteine desulfurase GPY24_RS06140 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GPY24_RS06145 ENOG4108Z4V iron-sulfur cluster assembly GPY24_RS06155 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY24_RS06160 ENOG4108ZIT Ferredoxin, 2FE-2S GPY24_RS06165 ENOG4105WVQ Fe-S assembly protein IscX GPY24_RS06175 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GPY24_RS06180 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GPY24_RS06195 ENOG4105CUT histidyl-tRNA synthetase GPY24_RS06215 ENOG410620I Diguanylate cyclase GPY24_RS06225 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY24_RS06230 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY24_RS06245 ENOG4106HK8 GPR1 FUN34 yaaH family protein GPY24_RS06250 ENOG41064T2 transcriptional regulator, lysR family GPY24_RS06255 ENOG4105EUZ Beta-lactamase domain protein GPY24_RS06265 ENOG4105MWK D-amino acid dehydrogenase, small subunit GPY24_RS06270 ENOG4107RSM transcriptional regulator GPY24_RS06285 ENOG4108K81 inner membrane protein YghB GPY24_RS06290 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY24_RS06305 ENOG4108KTG Membrane protein, drug metabolite transporter GPY24_RS06330 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GPY24_RS06335 ENOG4108Z1B Cyclase dehydrase GPY24_RS06340 ENOG4105VDB UPF0125 protein GPY24_RS06355 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GPY24_RS06375 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY24_RS06405 ENOG4105CFC Transporter GPY24_RS06410 ENOG4105C4W S-formylglutathione hydrolase GPY24_RS06415 ENOG4107QPD alcohol dehydrogenase GPY24_RS06420 ENOG4105CC0 LysR family Transcriptional regulator GPY24_RS06425 ENOG4108Z6B deaminase GPY24_RS06450 ENOG4105EKQ RNA-directed DNA polymerase GPY24_RS06475 ENOG4105C7N Xanthine uracil vitamin C permease GPY24_RS06480 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GPY24_RS06490 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GPY24_RS06495 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GPY24_RS06510 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPY24_RS06525 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GPY24_RS06530 ENOG4107YIM Involved in the transcription termination process (By similarity) GPY24_RS06540 ENOG4108ZAI phosphatidylglycerophosphatase a GPY24_RS06550 ENOG4105CTB Polyprenyl synthetase GPY24_RS06555 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY24_RS06560 ENOG4105E14 MotA TolQ exbB proton channel GPY24_RS06565 ENOG4105ER2 Ompa motb domain protein GPY24_RS06575 ENOG4105ETT transcriptional Regulator, LysR family GPY24_RS06590 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) GPY24_RS06605 ENOG4105EWT decarboxylase family GPY24_RS06610 ENOG4105BZU Histidine kinase GPY24_RS06620 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GPY24_RS06625 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GPY24_RS06630 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein GPY24_RS06635 ENOG4105D01 (LipO)protein GPY24_RS06640 ENOG4108UMI ABC transporter, permease GPY24_RS06650 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GPY24_RS06660 ENOG4105C5Y PTS System GPY24_RS06665 ENOG4105CG3 alpha amylase, catalytic region GPY24_RS06670 ENOG4105EKQ RNA-directed DNA polymerase GPY24_RS06705 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GPY24_RS06710 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GPY24_RS06715 ENOG4108Z43 UPF0250 protein GPY24_RS06720 ENOG4105DZ1 carboxypeptidase GPY24_RS06725 ENOG4105K6T rare lipoprotein A GPY24_RS06740 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GPY24_RS06745 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GPY24_RS06750 ENOG4105DJF DNA polymerase III, delta' subunit GPY24_RS06755 ENOG4108U2H Rare lipoprotein B GPY24_RS06765 ENOG4107PAI alpha helical protein GPY24_RS06770 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GPY24_RS06775 ENOG4108JU5 Magnesium and cobalt efflux protein GPY24_RS06785 ENOG4105C9A Phoh family GPY24_RS06795 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY24_RS06890 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GPY24_RS06900 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GPY24_RS06910 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GPY24_RS06920 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GPY24_RS06930 ENOG41063JG Transcriptional regulator GPY24_RS06935 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GPY24_RS06940 ENOG4105CGH 5'-nucleotidase GPY24_RS06945 ENOG4108Z66 YbaK ebsC protein GPY24_RS06950 ENOG4105FE9 pseudouridine synthase GPY24_RS06975 ENOG4105E2D ec 3.2.1.52 GPY24_RS06985 ENOG4105C59 p-type ATPase GPY24_RS07035 ENOG4107R88 Chemotaxis protein (CheV) GPY24_RS07040 ENOG4105BZU Histidine kinase GPY24_RS07045 ENOG4105BZU Histidine kinase GPY24_RS07050 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPY24_RS07055 ENOG4108ZC9 flagellar basal-body rod protein flgc GPY24_RS07060 ENOG4105W00 Flagellar hook capping protein GPY24_RS07070 ENOG4108KPB Flagellar basal-body rod protein FlgF GPY24_RS07080 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY24_RS07085 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY24_RS07090 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPY24_RS07100 ENOG4105DTJ flagellar hook-associated protein GPY24_RS07105 ENOG4105I03 Flagellin GPY24_RS07120 ENOG4105C5Y PTS System GPY24_RS07130 ENOG4105KZ7 phosphocarrier protein hpr GPY24_RS07135 ENOG4105C6T cysteine synthase GPY24_RS07140 ENOG4105EXN Sulfate transport protein CysZ GPY24_RS07145 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GPY24_RS07155 ENOG41081QG Porin Gram-negative type GPY24_RS07170 ENOG4107QX8 SPFH domain, Band 7 family protein GPY24_RS07175 ENOG4107QR8 Thioredoxin GPY24_RS07185 ENOG4105E1F short-chain dehydrogenase reductase GPY24_RS07215 ENOG4108RE9 Phosphodiesterase GPY24_RS07245 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GPY24_RS07265 ENOG4105CAQ asparagine synthetase GPY24_RS07270 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPY24_RS07275 ENOG4105E2R ROK family GPY24_RS07285 ENOG4105CI1 PTS System GPY24_RS07295 ENOG41090R7 Ferric uptake GPY24_RS07305 ENOG4105CMU LysR family (Transcriptional regulator GPY24_RS07310 ENOG4105VAW lrga family GPY24_RS07320 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GPY24_RS07330 ENOG4105EV9 Alpha Beta Hydrolase GPY24_RS07335 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GPY24_RS07355 ENOG4105BZN citrate synthase GPY24_RS07360 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GPY24_RS07365 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GPY24_RS07370 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GPY24_RS07375 ENOG4105E33 succinate dehydrogenase GPY24_RS07380 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GPY24_RS07385 ENOG4105C7S Dehydrogenase GPY24_RS07390 ENOG4105CMV Succinyl-CoA synthetase subunit beta GPY24_RS07395 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GPY24_RS07400 ENOG4105FAV ABC, transporter GPY24_RS07405 ENOG4105FDK ABC transporter GPY24_RS07410 ENOG4105NXV High-affinity zinc uptake system protein GPY24_RS07420 ENOG4105XFK Ferrous iron transport protein A GPY24_RS07425 ENOG4105CE1 Ferrous iron transport protein b GPY24_RS07440 ENOG4105C75 arginyL-tRNA synthetase GPY24_RS07445 ENOG4106ZCM YecM protein GPY24_RS07450 ENOG4105CIY formyltetrahydrofolate deformylase GPY24_RS07465 ENOG41072GX Peptidase M22 Glycoprotease GPY24_RS07475 ENOG4105R8X Outer membrane lipoprotein Slp GPY24_RS07480 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY24_RS07485 ENOG4105CEY Amp-dependent synthetase and ligase GPY24_RS07495 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GPY24_RS07500 ENOG4107QMS site-determining protein GPY24_RS07505 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GPY24_RS07520 ENOG4105EJC lysr family transcriptional regulator GPY24_RS07525 ENOG4105D9N nucleoside GPY24_RS07545 ENOG4105CNG UPF0061 protein GPY24_RS07550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY24_RS07555 ENOG4105E0F Histidine kinase GPY24_RS07570 ENOG4105DRS transport system, permease GPY24_RS07580 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GPY24_RS07585 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ GPY24_RS07590 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY24_RS07600 ENOG4105CQZ Histidine kinase GPY24_RS07610 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GPY24_RS07620 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GPY24_RS07630 ENOG4105K70 DNA-binding protein GPY24_RS07635 ENOG4105EIN peptidylprolyl cis-trans isomerase GPY24_RS07655 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GPY24_RS07670 ENOG4105E4F Isochorismate synthase GPY24_RS07680 ENOG4108IPT Naphthoate synthase GPY24_RS07690 ENOG4105CEY Amp-dependent synthetase and ligase GPY24_RS07695 ENOG4105HMI Membrane GPY24_RS07700 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GPY24_RS07740 ENOG4105BZS acriflavin resistance protein GPY24_RS07755 ENOG4108XM1 transcriptional regulator AsnC family GPY24_RS07760 ENOG4105C29 acyl-CoA thioesterase GPY24_RS07780 ENOG410620I Diguanylate cyclase GPY24_RS07855 ENOG4108WQI RNA Polymerase GPY24_RS07865 ENOG4105E18 UPF0276 protein GPY24_RS07885 ENOG4108NVR Methyl-accepting chemotaxis GPY24_RS07890 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY24_RS07900 ENOG4105CHH sulfate transporter GPY24_RS07905 ENOG4108K0B C-di-gmp phosphodiesterase GPY24_RS07910 ENOG4105C08 Histidine kinase GPY24_RS07915 ENOG4105EEX Two component transcriptional regulator (Winged helix family GPY24_RS07955 ENOG4105M6W Crispr-associated protein, Csy3 family GPY24_RS08015 ENOG4105EE5 Membrane protein terC GPY24_RS08020 ENOG4105D70 Integrase catalytic subunit GPY24_RS08030 ENOG4105EE5 Membrane protein terC GPY24_RS08040 ENOG4105CF7 AraC family transcriptional regulator GPY24_RS08055 ENOG4105ENX hydrolase GPY24_RS08100 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY24_RS08120 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY24_RS08140 ENOG4108NVR Methyl-accepting chemotaxis GPY24_RS08145 ENOG4105K59 histidine triad (HIT) protein GPY24_RS08170 ENOG4105D0Y UPF0227 protein GPY24_RS08175 ENOG4105CEP NADH dehydrogenase GPY24_RS08180 ENOG4105C72 UPF0176 protein GPY24_RS08195 ENOG4108JA2 transcriptioN-repair coupling factor GPY24_RS08205 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY24_RS08210 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY24_RS08215 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY24_RS08225 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GPY24_RS08235 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GPY24_RS08240 ENOG4105W49 UPF0434 protein GPY24_RS08265 ENOG4105XWI UPF0304 protein GPY24_RS08275 ENOG4105F1A Pyruvate formate-lyase GPY24_RS08290 ENOG4105C6N Formate acetyltransferase GPY24_RS08310 ENOG4108JEH abc transporter atp-binding protein GPY24_RS08315 ENOG4105E89 ABC transporter GPY24_RS08320 ENOG4105DSP amino acid AbC transporter GPY24_RS08325 ENOG4106YG3 ABC transporter GPY24_RS08340 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS08345 ENOG4106428 Protein of unknown function (DUF2496) GPY24_RS08350 ENOG4108URS primosomal replication protein n'' GPY24_RS08365 ENOG4105ZU8 porin-like protein H GPY24_RS08375 ENOG4108R99 pseudouridine synthase GPY24_RS08385 ENOG4105VEQ Cold shock protein GPY24_RS08390 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GPY24_RS08400 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GPY24_RS08410 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GPY24_RS08425 ENOG4105RKX Protein of unknown function (DUF2498) GPY24_RS08430 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY24_RS08435 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY24_RS08460 ENOG4105HP8 regulator of competence-specific genes GPY24_RS08475 ENOG4106WF9 DNA-binding transcriptional regulator TorR GPY24_RS08480 ENOG4107S90 membrAne GPY24_RS08485 ENOG4106371 Methyltransferase GPY24_RS08495 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GPY24_RS08520 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY24_RS08525 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GPY24_RS08535 ENOG41081XQ Conserved Protein GPY24_RS08540 ENOG4105C9M aspartyl-trna synthetase GPY24_RS08545 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GPY24_RS08550 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS08555 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GPY24_RS08565 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY24_RS08570 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY24_RS08585 ENOG4107YD3 Thioesterase GPY24_RS08595 ENOG4105M8F Biopolymer transport protein exbD tolR GPY24_RS08610 ENOG4105KCK Peptidoglycan-associated lipoprotein GPY24_RS08615 ENOG4105UFD tol-pal system protein YbgF GPY24_RS08620 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GPY24_RS08625 ENOG4105CDH Citrulline--aspartate ligase GPY24_RS08630 ENOG4105Z6B inner membrane protein yjfl GPY24_RS08640 ENOG4106032 Glutathionylspermidine synthase GPY24_RS08655 ENOG4105CA0 peroxidase GPY24_RS08675 ENOG4105BZU Histidine kinase GPY24_RS08680 ENOG4108RNS Exports L-alanine (By similarity) GPY24_RS08720 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GPY24_RS08890 ENOG4105CXY transporter GPY24_RS08895 ENOG4105BZU Histidine kinase GPY24_RS08900 ENOG4108KX4 response regulator GPY24_RS08905 ENOG4105CXY transporter GPY24_RS09025 ENOG4105CDV Ompa motb domain protein GPY24_RS09030 ENOG4105BZU Histidine kinase GPY24_RS09055 ENOG4105BZU Histidine kinase GPY24_RS09085 ENOG4105BZS acriflavin resistance protein GPY24_RS09110 ENOG4105CCT upf0313 protein GPY24_RS09115 ENOG4105BZU Histidine kinase GPY24_RS09150 ENOG4105NAU thioesterase Superfamily protein GPY24_RS09155 ENOG4107835 probably involved in intracellular septation (By similarity) GPY24_RS09165 ENOG4105CK2 sodium dicarboxylate symporter GPY24_RS09175 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPY24_RS09180 ENOG4105DK0 Indole-3-glycerol phosphate synthase GPY24_RS09185 ENOG4108I0Q anthranilate phosphoribosyltransferase GPY24_RS09190 ENOG4105DDQ anthranilate synthase GPY24_RS09195 ENOG4105CRQ synthase (Component I) GPY24_RS09205 ENOG4105DB7 PHP domain protein GPY24_RS09210 ENOG4107RTD sua5 ycio yrdc ywlc family protein GPY24_RS09215 ENOG4105FE9 pseudouridine synthase GPY24_RS09225 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY24_RS09235 ENOG4105BZU Histidine kinase GPY24_RS09245 ENOG4105WH1 Two component transcriptional regulator luxr family GPY24_RS09250 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GPY24_RS09290 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) GPY24_RS09315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY24_RS09320 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY24_RS09325 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY24_RS09330 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY24_RS09340 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GPY24_RS09370 ENOG4105EAQ (twin-arginine translocation) pathway signal GPY24_RS09375 ENOG4105C5X domain protein GPY24_RS09390 ENOG4105CH5 extracellular solute-binding protein, family 7 GPY24_RS09400 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY24_RS09415 ENOG41067TZ transcriptional regulator, MarR family GPY24_RS09425 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS09445 ENOG4105CGF Aromatic amino acid aminotransferase GPY24_RS09460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY24_RS09470 ENOG4105C5S asparaginyl-tRNA synthetase GPY24_RS09475 ENOG4108NVR Methyl-accepting chemotaxis GPY24_RS09480 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GPY24_RS09490 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY24_RS09500 ENOG4105EJQ L-serine dehydratase GPY24_RS09505 ENOG4105C44 Serine transporter GPY24_RS09515 ENOG4105CRQ synthase (Component I) GPY24_RS09540 ENOG4108JU8 Transcriptional regulator GPY24_RS09545 ENOG4105D9U N-acetyltransferase GPY24_RS09565 ENOG4105BZU Histidine kinase GPY24_RS09600 ENOG4105G0K glycine radical enzyme YjjI family GPY24_RS09605 ENOG41076CZ activating enzyme GPY24_RS09630 ENOG4105E0U tyrosine-specific transport protein GPY24_RS09640 ENOG4108RMU ferritin dps family protein GPY24_RS09655 ENOG4105BZ1 (ABC) transporter GPY24_RS09660 ENOG4105BZ1 (ABC) transporter GPY24_RS09705 ENOG4108NIW Leucine export protein LeuE GPY24_RS09715 ENOG4105CFG Acts as a chaperone (By similarity) GPY24_RS09785 ENOG4107IFA Lipase (EC 3.1.1.3) GPY24_RS09795 ENOG4105E5M Multidrug resistance protein D GPY24_RS09800 ENOG4105CYW agmatinase GPY24_RS09825 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPY24_RS09830 ENOG4105C0A alcohol dehydrogenase GPY24_RS09835 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) GPY24_RS09840 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GPY24_RS09850 ENOG4105DKG l-rhamnose isomerase GPY24_RS09855 ENOG4105DET Rhamnulokinase GPY24_RS09860 ENOG4105EKQ RNA-directed DNA polymerase GPY24_RS09895 ENOG4105BZU Histidine kinase GPY24_RS09900 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GPY24_RS09915 ENOG4106PG1 outer membrane usher protein GPY24_RS09925 ENOG4105H8W Fimbrial protein GPY24_RS09960 ENOG4105BZU Histidine kinase GPY24_RS09965 ENOG4107RH7 Nicotinate phosphoribosyltransferase GPY24_RS09980 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY24_RS09995 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GPY24_RS10000 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GPY24_RS10005 ENOG41067MG lrgb family GPY24_RS10015 ENOG4105CJB Exodeoxyribonuclease I GPY24_RS10030 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GPY24_RS10055 ENOG4108IU2 vtamin B12-transporter permease GPY24_RS10075 ENOG4107QF7 multi-drug GPY24_RS10080 ENOG4105DUM transcriptional regulator, lysR family GPY24_RS10090 ENOG4108VKG metal-dependent hydrolase GPY24_RS10095 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GPY24_RS10105 ENOG41090FY type IV pilus biogenesis stability protein PilW GPY24_RS10110 ENOG4105CVG Homoserine O-transsuccinylase GPY24_RS10120 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GPY24_RS10125 ENOG4105F1J Homogentisate 1,2-dioxygenase GPY24_RS10135 ENOG4108RXX maleylacetoacetate isomerase GPY24_RS10165 ENOG4107QZF nitrite reductase NADPH large subunit GPY24_RS10170 ENOG4105WZK nitrite reductase NADPH small subunit GPY24_RS10180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY24_RS10185 ENOG4105VEQ Cold shock protein GPY24_RS10200 ENOG4105EJ9 Membrane GPY24_RS10225 ENOG4105CR4 methylisocitrate lyase GPY24_RS10240 ENOG4105C7F AcnD-accessory protein PrpF GPY24_RS10245 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY24_RS10260 ENOG410667J hydrolase GPY24_RS10265 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GPY24_RS10275 ENOG4105BZU Histidine kinase GPY24_RS10285 ENOG4105CDV Ompa motb domain protein GPY24_RS10320 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GPY24_RS10325 ENOG4108MN8 Membrane GPY24_RS10330 ENOG4105CDA abc transporter atp-binding protein GPY24_RS10335 ENOG4105DRP amino acid AbC transporter GPY24_RS10340 ENOG4105EZ7 amino acid ABC transporter GPY24_RS10345 ENOG4107QXX ABC transporter GPY24_RS10360 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY24_RS10385 ENOG4105QNR S1 RNA binding domain protein GPY24_RS10395 ENOG4105DY2 Paraquat-inducible protein b GPY24_RS10400 ENOG4105H2K paraquat-inducible protein a GPY24_RS10405 ENOG4105BZ1 (ABC) transporter GPY24_RS10415 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GPY24_RS10420 ENOG4105CN1 protease GPY24_RS10450 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GPY24_RS10480 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GPY24_RS10485 ENOG4105DAN ATP-dependent protease GPY24_RS10525 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GPY24_RS10540 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) GPY24_RS10565 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPY24_RS10570 ENOG4105Q9Y Universal stress protein GPY24_RS10575 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GPY24_RS10585 ENOG4108UR8 BAX protein GPY24_RS10595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY24_RS10600 ENOG4105F38 ABC transporter, permease GPY24_RS10610 ENOG4107RUE extracellular solute-binding protein family 1 GPY24_RS10615 ENOG4107RUE extracellular solute-binding protein family 1 GPY24_RS10620 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GPY24_RS10630 ENOG4105C5H ABC transporter GPY24_RS10635 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GPY24_RS10640 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GPY24_RS10650 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GPY24_RS10655 ENOG4106IUH DTW domain containing protein GPY24_RS10665 ENOG4108N3W hemolysin secretion protein GPY24_RS10670 ENOG4105K4H Nlp p60 protein GPY24_RS10680 ENOG4105BZU Histidine kinase GPY24_RS10690 ENOG4105FGM Fructosamine kinase GPY24_RS10700 ENOG4108R6K riboflavin synthase, subunit alpha GPY24_RS10735 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GPY24_RS10740 ENOG4105DDV Transcriptional regulator (LacI family GPY24_RS10745 ENOG4105CS2 ec 3.2.1.21 GPY24_RS10750 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GPY24_RS10755 ENOG4105VSH 4-oxalocrotonate tautomerase GPY24_RS10770 ENOG4105EXG Transcriptional regulator GPY24_RS10795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY24_RS10805 ENOG4105E39 Enoyl-CoA hydratase GPY24_RS10810 ENOG4105C1G acyl-Coa dehydrogenase GPY24_RS10815 ENOG4105C26 Dehydrogenase GPY24_RS10820 ENOG4105CHU acetyl-coa acetyltransferase GPY24_RS10830 ENOG4105C1G acyl-Coa dehydrogenase GPY24_RS10845 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GPY24_RS10875 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY24_RS10880 ENOG41082YX Transcriptional regulator, arsr family GPY24_RS10895 ENOG4105CZK Aspartate kinase GPY24_RS10900 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GPY24_RS10905 ENOG4108JPW Aminotransferase GPY24_RS10910 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GPY24_RS10920 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GPY24_RS10930 ENOG4105CCU oxidase (Subunit III) GPY24_RS10940 ENOG4105E2S oxidase) subunit II GPY24_RS10955 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY24_RS10960 ENOG4108594 Permease of the drug metabolite transporter GPY24_RS10965 ENOG4105NXH GreA GreB family elongation factor GPY24_RS10995 ENOG4105I4A GCN5-related N-acetyltransferase GPY24_RS11070 ENOG410600T transposase GPY24_RS11085 ENOG4105VMI -acetyltransferase GPY24_RS11125 ENOG4105EST Metal Dependent Phosphohydrolase GPY24_RS11135 ENOG410600T transposase GPY24_RS11225 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GPY24_RS11400 ENOG4105D70 Integrase catalytic subunit GPY24_RS11600 ENOG4105KD7 acetyltransferase GPY24_RS11710 ENOG4105W08 virulence gene repressor rsal GPY24_RS11715 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system GPY24_RS11740 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY24_RS11775 ENOG4105VXN addiction module toxin, RelE StbE family GPY24_RS11830 ENOG4105KNA -acetyltransferase GPY24_RS12025 ENOG410600T transposase GPY24_RS12030 ENOG4105D70 Integrase catalytic subunit GPY24_RS12035 ENOG4105F5W AtP-binding protein GPY24_RS12130 ENOG4105D70 Integrase catalytic subunit GPY24_RS12375 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS12390 ENOG4105D70 Integrase catalytic subunit GPY24_RS12485 ENOG4108HYG acetyltransferase GPY24_RS12590 ENOG410600T transposase GPY24_RS13030 ENOG4105D70 Integrase catalytic subunit GPY24_RS13145 ENOG4105K4U addiction module toxin, RelE StbE family GPY24_RS13335 ENOG4105VXN addiction module toxin, RelE StbE family GPY24_RS13445 ENOG4105K4U addiction module toxin, RelE StbE family GPY24_RS13540 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GPY24_RS13545 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) GPY24_RS13555 ENOG4108MRH transcriptional regulatory protein GPY24_RS13560 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY24_RS13575 ENOG4107V40 secretion protein, HlyD family GPY24_RS13595 ENOG4105BZG amino acid carrier protein GPY24_RS13605 ENOG410829K Lysine exporter protein (Lyse ygga) GPY24_RS13610 ENOG4105CTD carboxy-peptidase GPY24_RS13625 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GPY24_RS13630 ENOG41082NX 50s ribosomal protein l35 GPY24_RS13635 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GPY24_RS13640 ENOG4105C22 threonyL-tRNA synthetase GPY24_RS13655 ENOG4105CI2 imidazolone-5-propionate hydrolase GPY24_RS13665 ENOG4105CGP Urocanate hydratase GPY24_RS13700 ENOG4108ZXC Two component transcriptional regulator, luxr family GPY24_RS13705 ENOG4106AFQ Histidine kinase GPY24_RS13725 ENOG4108RSN SNARE associated Golgi GPY24_RS13730 ENOG4105VNH ABC transporter solute-binding protein GPY24_RS13740 ENOG4108VGW abc transporter atp-binding protein GPY24_RS13745 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GPY24_RS13755 ENOG4108ZG0 Ompa motb domain protein GPY24_RS13775 ENOG4105C8V SAICAR synthetase GPY24_RS13795 ENOG4105CQ7 ATP-dependent helicase GPY24_RS13805 ENOG4107GZ4 SanA protein GPY24_RS13810 ENOG4105C8P )-transporter GPY24_RS13815 ENOG4105BZU Histidine kinase GPY24_RS13835 ENOG4105C3M thioredoxin reductase GPY24_RS13860 ENOG4105BZU Histidine kinase GPY24_RS13885 ENOG4105DWU Membrane GPY24_RS13895 ENOG4105DY8 decarboxylase GPY24_RS13900 ENOG4106KNT transcriptional regulator GPY24_RS13910 ENOG41090BQ Glutaredoxin GPY24_RS13920 ENOG4105RKW reductase (By GPY24_RS13925 ENOG4107QPN acyl-Coa dehydrogenase GPY24_RS13935 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY24_RS13955 ENOG4107QI1 Mate efflux family protein GPY24_RS13960 ENOG4105CGD Nad-dependent epimerase dehydratase GPY24_RS13975 ENOG4105I08 Pseudouridine synthase GPY24_RS13980 ENOG4105CFI type iii restriction protein res subunit GPY24_RS13995 ENOG4105DHQ Histidine kinase GPY24_RS14000 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GPY24_RS14005 ENOG4105CGH 5'-nucleotidase GPY24_RS14015 ENOG4105XZD Fe-S protein GPY24_RS14035 ENOG4108W1A pseudouridine synthase GPY24_RS14045 ENOG4105EKQ RNA-directed DNA polymerase GPY24_RS14050 ENOG4105EKQ RNA-directed DNA polymerase GPY24_RS14060 ENOG4105C8J )-transporter GPY24_RS14070 ENOG4105C28 cystathionine GPY24_RS14075 ENOG4108R3E Dna-3-methyladenine glycosylase i GPY24_RS14085 ENOG4105FM1 phage shock protein C GPY24_RS14090 ENOG4105YYT phage shock protein B GPY24_RS14100 ENOG4105E51 psp operon transcriptional activator GPY24_RS14105 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY24_RS14110 ENOG4108I5W peptide transport system, permease protein GPY24_RS14120 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GPY24_RS14125 ENOG4108JQ2 peptide transport system atp-binding protein GPY24_RS14190 ENOG4108535 NAD dependent epimerase/dehydratase family GPY24_RS14200 ENOG4105C8N cysteinyl-tRNA synthetase GPY24_RS14215 ENOG4105D58 Diguanylate phosphodiesterase GPY24_RS14220 ENOG4105K5B UPF0225 protein GPY24_RS14230 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GPY24_RS14265 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GPY24_RS14270 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GPY24_RS14290 ENOG4105CIH Imidazole acetol-phosphate transaminase GPY24_RS14300 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GPY24_RS14305 ENOG4107S6Z Na H antiporter GPY24_RS14310 ENOG4108SAU DNA-binding protein H-ns GPY24_RS14315 ENOG4107RE1 Inosine-guanosine kinase GPY24_RS14330 ENOG41075W9 High frequency lysogenization protein HflD homolog GPY24_RS14335 ENOG4107QTF adenylosuccinate lyase GPY24_RS14345 ENOG4105RHG GPY24_RS14370 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GPY24_RS14385 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GPY24_RS14390 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GPY24_RS14395 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY24_RS14410 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GPY24_RS14420 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GPY24_RS14430 ENOG4105EW9 transcriptional regulator AsnC family GPY24_RS14435 ENOG4105DCF alanine dehydrogenase GPY24_RS14445 ENOG4107R11 Transcriptional regulator GPY24_RS14470 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPY24_RS14475 ENOG4105KT5 UmuD protein GPY24_RS14830 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GPY24_RS14860 ENOG4108JQ7 (ABC) transporter GPY24_RS14875 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPY24_RS14885 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GPY24_RS14895 ENOG4105Q4A inner membrane protein yciS GPY24_RS14900 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY24_RS14905 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GPY24_RS14910 ENOG4105CAT Cytidine monophosphate kinase GPY24_RS14915 ENOG4105ERU peptidase GPY24_RS14920 ENOG4105UBK short-chain dehydrogenase reductase GPY24_RS14930 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA GPY24_RS14940 ENOG4107R88 Chemotaxis protein (CheV) GPY24_RS14945 ENOG4105DAG ROK family GPY24_RS14950 ENOG4105CA9 Pyruvate kinase GPY24_RS14955 ENOG4108NRW Phospholipase, patatin family GPY24_RS14970 ENOG4105C8J )-transporter GPY24_RS14980 ENOG4105CI1 PTS System GPY24_RS14985 ENOG4105F8V Hydrolase, tatD family GPY24_RS14990 ENOG4107QRG dna polymerase iii GPY24_RS15000 ENOG4105HHA aminodeoxychorismate lyase GPY24_RS15010 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY24_RS15015 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPY24_RS15020 ENOG4105CHR reductase GPY24_RS15025 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GPY24_RS15035 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GPY24_RS15040 ENOG4105VGS 50s ribosomal protein l32 GPY24_RS15045 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GPY24_RS15060 ENOG4105C03 ribonuclease GPY24_RS15070 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GPY24_RS15080 ENOG4105DBI uridine monophosphokinase GPY24_RS15085 ENOG4105D1F ATP-binding protein GPY24_RS15100 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GPY24_RS15110 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GPY24_RS15115 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GPY24_RS15120 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GPY24_RS15130 ENOG4108JJB ABC transporter GPY24_RS15135 ENOG4105C7J ABC transporter, permease GPY24_RS15150 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY24_RS15160 ENOG4107PU6 Membrane GPY24_RS15165 ENOG4105CHF Glutathione S-transferase GPY24_RS15170 ENOG4105EKQ RNA-directed DNA polymerase GPY24_RS15175 ENOG4108JQ7 (ABC) transporter GPY24_RS15185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY24_RS15190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY24_RS15195 ENOG4107QSI ABC, transporter GPY24_RS15205 ENOG4105M00 molybdopterin converting factor, subunit 1 GPY24_RS15210 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY24_RS15215 ENOG4108RIR Molybdenum cofactor biosynthesis protein GPY24_RS15220 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY24_RS15225 ENOG4105CHW UPF0052 protein GPY24_RS15240 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GPY24_RS15255 ENOG4105F1S paraquat-inducible protein a GPY24_RS15260 ENOG4105DY2 Paraquat-inducible protein b GPY24_RS15280 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY24_RS15285 ENOG4105CW7 secretion protein, HlyD family GPY24_RS15300 ENOG4108R3D Electron transport complex GPY24_RS15310 ENOG4105D6A Electron transport complex GPY24_RS15325 ENOG4105CSM endonuclease III GPY24_RS15330 ENOG4108UYE Lactoylglutathione lyase GPY24_RS15335 ENOG4106WH9 Protein of unknown function (DUF2753) GPY24_RS15340 ENOG4105EIY sodium-type flagellar protein motY GPY24_RS15350 ENOG4105D3Y Na H antiporter GPY24_RS15360 ENOG4105M2J Glutaredoxin GPY24_RS15390 ENOG4105EYW Ion transport protein GPY24_RS15395 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY24_RS15415 ENOG4105YDX UPF0352 protein GPY24_RS15420 ENOG4105E68 Sulfatase GPY24_RS15425 ENOG4105IJJ transcriptional regulator, crp fnr family GPY24_RS15440 ENOG4105DGU Histone deacetylase GPY24_RS15445 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY24_RS15450 ENOG41069NU Nitroreductase GPY24_RS15455 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY24_RS15460 ENOG4105D07 Signal peptide peptidase, SppA GPY24_RS15465 ENOG4105HDK L-asparaginase GPY24_RS15470 ENOG4105VUT cytoplasmic protein GPY24_RS15480 ENOG4105E0X reductase GPY24_RS15485 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY24_RS15490 ENOG4105DSB aldose 1-epimerase GPY24_RS15495 ENOG4107SDU Methyl-accepting chemotaxis GPY24_RS15500 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GPY24_RS15515 ENOG4108IQK o-acetylhomoserine GPY24_RS15525 ENOG4105CJW magnesium transporter GPY24_RS15550 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GPY24_RS15570 ENOG4105G6Z alkaline phosphatase GPY24_RS15580 ENOG4105KRS Proteinase inhibitor GPY24_RS15585 ENOG4107EXC regulatoR GPY24_RS15590 ENOG4105JJR Histidine kinase GPY24_RS15605 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GPY24_RS15610 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GPY24_RS15615 ENOG4107QMP dna polymerase iii subunits gamma and tau GPY24_RS15620 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GPY24_RS15625 ENOG4105WD1 Membrane GPY24_RS15655 ENOG4105E96 Colicin v production protein GPY24_RS15660 ENOG4108S3P Sporulation domain protein GPY24_RS15670 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GPY24_RS15675 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GPY24_RS15690 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) GPY24_RS15695 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY24_RS15700 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GPY24_RS15715 ENOG4108BPE -transporting atpase GPY24_RS15720 ENOG4105EN6 Membrane GPY24_RS15730 ENOG4108R4R Iron-regulated virulence regulatory protein GPY24_RS15735 ENOG410642W LysR family Transcriptional regulator GPY24_RS15745 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GPY24_RS15755 ENOG4108BY2 phosphohistidine phosphatase GPY24_RS15760 ENOG4108JQM Insulinase (Peptidase family M16) GPY24_RS15805 ENOG4108M1T Cytochrome c-type biogenesis protein GPY24_RS15810 ENOG4107QX9 Thiol disulfide interChange protein GPY24_RS15815 ENOG4105DA4 cytochrome c-type biogenesis protein GPY24_RS15825 ENOG4105X3C heme exporter protein GPY24_RS15830 ENOG41060IM Heme exporter protein GPY24_RS15835 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GPY24_RS15840 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GPY24_RS15860 ENOG4107QJE Chromosome Partitioning Protein GPY24_RS15870 ENOG4105CBS Chea signal transduction histidine kinase GPY24_RS15875 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GPY24_RS15880 ENOG4108VYJ response regulator receiver protein GPY24_RS15885 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY24_RS15895 ENOG4105FZW flagellar biosynthesis regulator FlhF GPY24_RS15910 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPY24_RS15915 ENOG4105VS8 Flagellar biosynthetic protein fliq GPY24_RS15920 ENOG4105CN7 Flagellar biosynthetic protein FliP GPY24_RS15925 ENOG4105VTB flagellar biosynthesis protein fliO GPY24_RS15930 ENOG4105DD5 Flagellar motor switch protein GPY24_RS15935 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY24_RS15960 ENOG4108JIR Flagellum-specific ATP synthase GPY24_RS15970 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY24_RS15980 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GPY24_RS15985 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY24_RS15990 ENOG4105BZU Histidine kinase GPY24_RS15995 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY24_RS16000 ENOG4105MQ3 flagellar protein FliS GPY24_RS16010 ENOG4107BRV flagellar capping protein GPY24_RS16015 ENOG41063QE flagellar protein FlaG GPY24_RS16025 ENOG4105I03 Flagellin GPY24_RS16030 ENOG4105I03 Flagellin GPY24_RS16035 ENOG4105EZR dyp-type peroxidase family protein GPY24_RS16040 ENOG4105QZU Inner membrane protein YfeZ GPY24_RS16065 ENOG4105KUZ arsenate reductase GPY24_RS16070 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPY24_RS16090 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY24_RS16100 ENOG4105RH4 Glycine cleavage system transcriptional repressor GPY24_RS16105 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GPY24_RS16120 ENOG4105ERG peptidase m48, ste24p GPY24_RS16125 ENOG4105K89 arsenate reductase GPY24_RS16130 ENOG4105CS1 NAD(P)H quinone oxidoreductase GPY24_RS16145 ENOG4105C2W permease GPY24_RS16155 ENOG4105CXB phosphoribosylaminoimidazole synthetase GPY24_RS16165 ENOG4105E7A Glutamine amidotransferase GPY24_RS16170 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY24_RS16185 ENOG4108JDX DNA polymerase iii, epsilon subunit GPY24_RS16190 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY24_RS16195 ENOG4105D1A Methyltransferase GPY24_RS16205 ENOG4105E9H Lytic Murein transglycosylase GPY24_RS16220 ENOG4108YZA Nitrogen regulatory protein pii GPY24_RS16225 ENOG4105N7H Cytochrome GPY24_RS16230 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GPY24_RS16235 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GPY24_RS16245 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY24_RS16250 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY24_RS16255 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY24_RS16260 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY24_RS16285 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GPY24_RS16290 ENOG4105KNE Phosphatidate cytidylyltransferase GPY24_RS16300 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GPY24_RS16305 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GPY24_RS16310 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GPY24_RS16315 ENOG4105CE9 30S ribosomal protein S2 GPY24_RS16320 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GPY24_RS16330 ENOG4108T8E UPF0325 protein GPY24_RS16335 ENOG4105DR9 pseudouridine synthase GPY24_RS16340 ENOG4105WP7 tRNA pseudouridine synthase C GPY24_RS16365 ENOG4108UPT UPF0178 protein GPY24_RS16370 ENOG4105CFC Transporter GPY24_RS16380 ENOG4105NRA 50s ribosomal protein l31 type b GPY24_RS16390 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GPY24_RS16400 ENOG4105W1I UPF0253 protein GPY24_RS16410 ENOG4105C8J )-transporter GPY24_RS16430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPY24_RS16445 ENOG4105CJ2 (LipO)protein GPY24_RS16450 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GPY24_RS16455 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY24_RS16460 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY24_RS16465 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY24_RS16470 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY24_RS16475 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY24_RS16480 ENOG4105M85 Bola protein GPY24_RS16495 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY24_RS16510 ENOG4105K6V RNA polymerase GPY24_RS16520 ENOG4105DRB nucleoside-specific channel-forming protein GPY24_RS16525 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GPY24_RS16530 ENOG4107S0N DJ-1 family GPY24_RS16535 ENOG4105C9B Cysteine desulfurase GPY24_RS16540 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GPY24_RS16545 ENOG4105CUZ uba thif-type nad fad binding protein GPY24_RS16550 ENOG4105CA3 membrane-bound lytic murein transglycosylase GPY24_RS16560 ENOG4107QZM n-acetylglutamate synthase GPY24_RS16570 ENOG4107QYX exodeoxyribonuclease v alpha GPY24_RS16575 ENOG4107QKA exodeoxyribonuclease V beta GPY24_RS16580 ENOG4105DSY exodeoxyribonuclease V, gamma GPY24_RS16585 ENOG4105E68 Sulfatase GPY24_RS16595 ENOG4105EVZ LysR family transcriptional regulator GPY24_RS16600 ENOG4105X2V dna damage-inducible protein GPY24_RS16605 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GPY24_RS16615 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GPY24_RS16620 ENOG4105E98 transcriptional regulator DeoR family GPY24_RS16625 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GPY24_RS16635 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GPY24_RS16665 ENOG4105DQS Transcriptional regulator GPY24_RS16670 ENOG4105CAH Chromate GPY24_RS16685 ENOG4105ETT transcriptional Regulator, LysR family GPY24_RS16695 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GPY24_RS16705 ENOG4105EAC phosphoserine phosphatase GPY24_RS16715 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY24_RS16720 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GPY24_RS16725 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GPY24_RS16740 ENOG4105EYA deoxyribonuclease GPY24_RS16750 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GPY24_RS16770 ENOG4108YYD acetyltransferase GPY24_RS16775 ENOG4105XPQ lipid carrier protein GPY24_RS16780 ENOG4105BZU Histidine kinase GPY24_RS16785 ENOG4105CFP Peptidase U32 GPY24_RS16790 ENOG4106RZ4 Peptidase U32 GPY24_RS16795 ENOG4105C3S Mate efflux family protein GPY24_RS16805 ENOG4105RT1 May be involved in cell division (By similarity) GPY24_RS16810 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GPY24_RS16815 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GPY24_RS16820 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GPY24_RS16825 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GPY24_RS16835 ENOG4105CHV Transcription elongation factor NusA GPY24_RS16840 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GPY24_RS16865 ENOG4105EEI dihydropteroate synthase GPY24_RS16870 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GPY24_RS16880 ENOG4105HBR Rna-binding protein GPY24_RS16885 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPY24_RS16890 ENOG4107QE9 Inherit from COG: Membrane GPY24_RS16900 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY24_RS16905 ENOG4105DR5 peptidase GPY24_RS16920 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GPY24_RS16925 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GPY24_RS16935 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY24_RS16945 ENOG4105DEF Extracellular solute-binding protein, family 5 GPY24_RS16955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY24_RS16960 ENOG4105C3U ABC transporter GPY24_RS16975 ENOG4105RD7 BadF BadG BcrA BcrD GPY24_RS16980 ENOG4105E2D ec 3.2.1.52 GPY24_RS16985 ENOG4105E2V Glycosyltransferase 36 GPY24_RS16995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY24_RS17000 ENOG4105E0C molybdate abc transporter GPY24_RS17015 ENOG4108YZA Nitrogen regulatory protein pii GPY24_RS17020 ENOG4105D05 Receptor GPY24_RS17025 ENOG410804D Sensor Signal Transduction Histidine Kinase GPY24_RS17030 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY24_RS17045 ENOG4105DIK (ABC) transporter GPY24_RS17085 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GPY24_RS17090 ENOG4107QQ0 gntp family GPY24_RS17095 ENOG4105BZW Glycerate kinase GPY24_RS17105 ENOG4105D78 K07001 NTE family protein GPY24_RS17120 ENOG4105PW4 Sugar fermentation stimulation protein homolog GPY24_RS17125 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GPY24_RS17135 ENOG4105DJ0 Poly(A) Polymerase GPY24_RS17140 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY24_RS17145 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GPY24_RS17150 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GPY24_RS17155 ENOG4105E3A (ABC) transporter GPY24_RS17160 ENOG4105DA5 (ABC) transporter GPY24_RS17165 ENOG4105CHH sulfate transporter GPY24_RS17170 ENOG41077A9 carbonic anhydrase GPY24_RS17175 ENOG4108UGV hypoxanthine phosphoribosyltransferase GPY24_RS17185 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY24_RS17195 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GPY24_RS17200 ENOG41073TP transcriptional regulator GPY24_RS17210 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GPY24_RS17220 ENOG4107QHF type ii secretion system protein e GPY24_RS17230 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GPY24_RS17240 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GPY24_RS17250 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GPY24_RS17255 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GPY24_RS17260 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GPY24_RS17265 ENOG4105K5M 30s ribosomal protein S16 GPY24_RS17270 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GPY24_RS17275 ENOG4106KVJ cytochrome C assembly protein GPY24_RS17280 ENOG4108JU6 CBS domain protein GPY24_RS17285 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GPY24_RS17295 ENOG4105D9M gamma-glutamylcysteine synthetase GPY24_RS17305 ENOG4105W39 Membrane GPY24_RS17315 ENOG4105D9Q decarboxylase (Beta subunit) GPY24_RS17320 ENOG4107QSA Oxaloacetate decarboxylase GPY24_RS17375 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GPY24_RS17380 ENOG4105CFH Aspartokinase GPY24_RS17390 ENOG4105Y3E Modulates RecA activity (By similarity) GPY24_RS17405 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GPY24_RS17420 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GPY24_RS17425 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GPY24_RS17430 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GPY24_RS17435 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GPY24_RS17440 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GPY24_RS17445 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPY24_RS17455 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GPY24_RS17460 ENOG4105DXN mazG family GPY24_RS17465 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY24_RS17470 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GPY24_RS17485 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GPY24_RS17490 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GPY24_RS17495 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GPY24_RS17500 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GPY24_RS17505 ENOG4105C3F Signal peptidase i GPY24_RS17515 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GPY24_RS17520 ENOG4105VQK sigma E regulatory protein, MucB RseB GPY24_RS17530 ENOG4105EMN RNA polymerase sigma factor GPY24_RS17545 ENOG4105Y75 tpr repeat protein GPY24_RS17570 ENOG4105D0A hydroxylase GPY24_RS17580 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GPY24_RS17590 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GPY24_RS17595 ENOG4105E66 phosphoriboisomerase A GPY24_RS17600 ENOG4108JQ1 Dehydrogenase GPY24_RS17630 ENOG4105BZA Phosphoglycerate kinase GPY24_RS17640 ENOG4105D05 Receptor GPY24_RS17645 ENOG4108R4R Iron-regulated virulence regulatory protein GPY24_RS17650 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY24_RS17660 ENOG4105GPY SprT protein GPY24_RS17665 ENOG4105RWS endonuclease I GPY24_RS17675 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GPY24_RS17680 ENOG4105D7Z glutathione synthase GPY24_RS17685 ENOG4108UJU UPF0301 protein GPY24_RS17695 ENOG4105CZX twitching motility protein GPY24_RS17705 ENOG4105DFA alanine racemase domain protein GPY24_RS17715 ENOG4108VIA integral membrane protein GPY24_RS17720 ENOG4105VZ9 UPF0235 protein GPY24_RS17735 ENOG4105CSA Coproporphyrinogen iii oxidase GPY24_RS17745 ENOG4105CSV Glutaminase GPY24_RS17750 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GPY24_RS17760 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GPY24_RS17765 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GPY24_RS17820 ENOG4105C26 Dehydrogenase GPY24_RS17930 ENOG4105I03 Flagellin GPY24_RS17940 ENOG4108K5H permease YjgP YjgQ family protein GPY24_RS17945 ENOG4108M8S permease YjgP YjgQ family protein GPY24_RS17950 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY24_RS17955 ENOG4105MYG DNA polymerase iii, chi subunit GPY24_RS17960 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GPY24_RS17980 ENOG4108MJ3 acetyltransferase GPY24_RS17995 ENOG4105CEU Arginine dihydrolase GPY24_RS18000 ENOG4105DBV ornithine carbamoyltransferase GPY24_RS18005 ENOG4105CXT aspartate transcarbamylase GPY24_RS18015 ENOG4105KME endoribonuclease L-psp GPY24_RS18020 ENOG4105C5I Dehydrogenase GPY24_RS18025 ENOG4105D3G Pseudouridine synthase GPY24_RS18035 ENOG4108IAB Phoh family GPY24_RS18040 ENOG4105D1U peptidase U62 modulator of DNA gyrase GPY24_RS18050 ENOG4105QD6 exported protein GPY24_RS18055 ENOG4105C03 ribonuclease GPY24_RS18065 ENOG4105VQ7 Rod shape-determining protein MreD GPY24_RS18070 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GPY24_RS18075 ENOG4105DFF Rod shape-determining protein mreb GPY24_RS18115 ENOG4105X0D Fimbrial protein GPY24_RS18130 ENOG4105D7Q type ii secretion system GPY24_RS18150 ENOG4105E4G Type IV pilus GPY24_RS18170 ENOG41062P1 Diguanylate cyclase phosphodiesterase GPY24_RS18175 ENOG4108UUM single-stranded DNA-binding protein GPY24_RS18180 ENOG41086KC Transcriptional regulator GPY24_RS18185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPY24_RS18200 ENOG4105C5R Aminotransferase GPY24_RS18215 ENOG4105EEQ Na H antiporter GPY24_RS18220 ENOG4106TD9 Diguanylate cyclase GPY24_RS18290 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GPY24_RS18295 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GPY24_RS18300 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GPY24_RS18320 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY24_RS18325 ENOG4105MYN Zinc uptake regulation protein GPY24_RS18335 ENOG4107QP8 phosphohexose isomerase GPY24_RS18340 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GPY24_RS18355 ENOG4105CDU Replicative dna helicase GPY24_RS18365 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GPY24_RS18370 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GPY24_RS18375 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GPY24_RS18380 ENOG4105DJV ribulose-phosphate 3-epimerase GPY24_RS18385 ENOG4105DFE Dna adenine methylase GPY24_RS18395 ENOG4105D49 3-dehydroquinate synthase GPY24_RS18400 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GPY24_RS18430 ENOG4108JQC penicillin-binding protein 1A GPY24_RS18435 ENOG4105C5Q Transcriptional regulator GPY24_RS18455 ENOG4105CAS nag kinase GPY24_RS18480 ENOG4105SYT Methylenetetrahydrofolate reductase GPY24_RS18495 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GPY24_RS18500 ENOG4105C6K Malic enzyme GPY24_RS18520 ENOG4105C25 Primosomal protein n' GPY24_RS18525 ENOG4105ETE Transcriptional regulator (LacI family GPY24_RS18535 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GPY24_RS18540 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GPY24_RS18545 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GPY24_RS18550 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY24_RS18555 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GPY24_RS18560 ENOG4105CBT Fructose-1,6-bisphosphatase GPY24_RS18580 ENOG4105CP7 Triose-phosphate isomerase GPY24_RS18590 ENOG4105CMR udp-glucose 4-epimerase GPY24_RS18605 ENOG4105CY0 Metallo-Beta-Lactamase GPY24_RS18610 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPY24_RS18615 ENOG4105ESV Glycosyl transferase, family 4 GPY24_RS18645 ENOG4105EIP mannose-6-phosphate isomerase GPY24_RS18650 ENOG4106ECQ phosphomannomutase GPY24_RS18660 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GPY24_RS18665 ENOG4105FGF GDP-mannose mannosyl hydrolase GPY24_RS18670 ENOG4105C30 Nad-dependent epimerase dehydratase GPY24_RS18680 ENOG4107S6X Glycosyl transferase, family 2 GPY24_RS18695 ENOG410600T transposase GPY24_RS18700 ENOG410600T transposase GPY24_RS18705 ENOG410600T transposase GPY24_RS18710 ENOG4108MY6 biosynthesis protein GPY24_RS18725 ENOG4105F0R Cytidylyltransferase GPY24_RS18730 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GPY24_RS18735 ENOG4105C5E polysaccharide biosynthesis protein GPY24_RS18755 ENOG4105DAY polysaccharide export protein GPY24_RS18775 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY24_RS18795 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GPY24_RS18800 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GPY24_RS18810 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GPY24_RS18820 ENOG4105EQK -acetyltransferase GPY24_RS18865 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase GPY24_RS18870 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GPY24_RS18885 ENOG4108SHN Glycosyl transferase, family 2 GPY24_RS18905 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY24_RS18915 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GPY24_RS18920 ENOG4105C1B dTDP-glucose 4-6-dehydratase GPY24_RS18925 ENOG4105E68 Sulfatase GPY24_RS18935 ENOG41080IJ Diacylglycerol kinase GPY24_RS18945 ENOG4106WTF Glycosyl transferase, family 2 GPY24_RS18950 ENOG4105M5K heptosyltransferase GPY24_RS18955 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GPY24_RS18965 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GPY24_RS18975 ENOG4105W0E 50S ribosomal protein L33 GPY24_RS18980 ENOG4105KDC 50s ribosomal protein l28 GPY24_RS18990 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS19000 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GPY24_RS19010 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GPY24_RS19015 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GPY24_RS19020 ENOG4105DSJ YicC domain protein GPY24_RS19120 ENOG4105VFU Rna-binding protein GPY24_RS19135 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GPY24_RS19155 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GPY24_RS19165 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GPY24_RS19180 ENOG4105SUU thioesterase domain GPY24_RS19185 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GPY24_RS19215 ENOG4105CUX Signal transduction histidine kinase GPY24_RS19230 ENOG4105D4P Coproporphyrinogen iii oxidase GPY24_RS19235 ENOG4105XCT Protein of unknown function (DUF2489) GPY24_RS19260 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GPY24_RS19275 ENOG4105D52 delta-aminolevulinic acid dehydratase GPY24_RS19280 ENOG4105F8V Hydrolase, tatD family GPY24_RS19285 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GPY24_RS19290 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GPY24_RS19295 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GPY24_RS19300 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GPY24_RS19305 ENOG4105JC1 sterol-binding domain protein GPY24_RS19310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GPY24_RS19330 ENOG4105BZU Histidine kinase GPY24_RS19335 ENOG4105CBX hi0933 family GPY24_RS19340 ENOG4108V6B universal stress protein B GPY24_RS19345 ENOG41090A1 ferritin GPY24_RS19350 ENOG4108M6U Universal stress protein A GPY24_RS19355 ENOG4105EMK carboxylate amino acid amine transporter GPY24_RS19365 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GPY24_RS19370 ENOG4105BZU Histidine kinase GPY24_RS19375 ENOG4108VVK transcriptional Regulator, AsnC GPY24_RS19385 ENOG4105D6S protein involved in catabolism of external DNA GPY24_RS19405 ENOG4105C2C drug resistance transporter, Bcr CflA GPY24_RS19410 ENOG4108UHU Aldolase GPY24_RS19415 ENOG4105C6Z Gluconate GPY24_RS19420 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GPY24_RS19425 ENOG4105C01 Dihydroxy-acid dehydratase GPY24_RS19430 ENOG4105DIQ Transcriptional regulator GPY24_RS19445 ENOG4105D9P serine threonine protein kinase GPY24_RS19480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY24_RS19485 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY24_RS19490 ENOG4107QSI ABC, transporter GPY24_RS19525 ENOG4105MPD Cytochrome GPY24_RS19535 ENOG4105Y7M Transcriptional regulator, TetR family GPY24_RS19550 ENOG4105W0Z cytoplasmic protein GPY24_RS19555 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GPY24_RS19560 ENOG4105EMY transcriptional regulator GPY24_RS19585 ENOG4108RR8 protoporphyrinogen oxidase GPY24_RS19590 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY24_RS19595 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GPY24_RS19600 ENOG4108DP9 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GPY24_RS19610 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GPY24_RS19625 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GPY24_RS19630 ENOG4105DUM transcriptional regulator, lysR family GPY24_RS19635 ENOG4105CS1 NAD(P)H quinone oxidoreductase GPY24_RS19665 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPY24_RS19685 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GPY24_RS19690 ENOG4105JKW Valine--pyruvate aminotransferase GPY24_RS19695 ENOG4108ZNX Heat shock protein GPY24_RS19705 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GPY24_RS19710 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GPY24_RS19715 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GPY24_RS19720 ENOG4105EAB amino acid AbC transporter GPY24_RS19725 ENOG4105E5Q amino acid AbC transporter GPY24_RS19735 ENOG4105VG0 50S ribosomal protein l34 GPY24_RS19740 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GPY24_RS19745 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GPY24_RS19755 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GPY24_RS19765 ENOG410787A Pts system, glucitol sorbitol-specific GPY24_RS19775 ENOG4105VI0 Pts system, glucitol sorbitol-specific GPY24_RS19780 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GPY24_RS19790 ENOG410804X Transcriptional regulator GPY24_RS19795 ENOG410787A Pts system, glucitol sorbitol-specific GPY24_RS19800 ENOG4105DZY Pts system, glucitol sorbitol-specific GPY24_RS19810 ENOG4105QTB Flavodoxin GPY24_RS19820 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GPY24_RS19825 ENOG4107QJE Chromosome Partitioning Protein GPY24_RS19830 ENOG4105FA0 parb-like partition protein GPY24_RS19835 ENOG410684E atp synthase GPY24_RS19840 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GPY24_RS19845 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY24_RS19850 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY24_RS19855 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY24_RS19865 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GPY24_RS19875 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GPY24_RS19880 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPY24_RS19885 ENOG4105CZQ inner membrane transport protein YdhC GPY24_RS19890 ENOG4105F52 Transcriptional regulator GPY24_RS19895 ENOG4105C7B Threonine dehydratase GPY24_RS19900 ENOG4105C01 Dihydroxy-acid dehydratase GPY24_RS19905 ENOG4105CM2 brancheD-chain amino acid aminotransferase GPY24_RS19910 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GPY24_RS19920 ENOG4105C0P Mg chelatase subunit ChlI GPY24_RS19930 ENOG4106HNH Acyl-transferase GPY24_RS19935 ENOG4108Z33 Thiol disulfide Interchange Protein GPY24_RS19950 ENOG4105PC1 Conserved Protein GPY24_RS19955 ENOG4108N23 SpoOM-related protein GPY24_RS19970 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY24_RS19985 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GPY24_RS19990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY24_RS20000 ENOG4105C79 DNA protecting protein DprA GPY24_RS20005 ENOG4108RPN Protein smg homolog GPY24_RS20010 ENOG4108WI1 Dna topoisomerase GPY24_RS20015 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GPY24_RS20020 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GPY24_RS20025 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY24_RS20030 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GPY24_RS20035 ENOG4105E2X shikimate dehydrogenase GPY24_RS20040 ENOG4105SG3 Protein of unknown function (DUF1488) GPY24_RS20045 ENOG4108Z0R Transferase GPY24_RS20100 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GPY24_RS20105 ENOG4105D06 uba thif-type nad fad binding protein GPY24_RS20115 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GPY24_RS20120 ENOG4105D41 biosynthesis protein thiH GPY24_RS20180 ENOG4105FR1 rard protein GPY24_RS20195 ENOG4105EX9 Membrane GPY24_RS20200 ENOG4105C9X ppx gppa phosphatase GPY24_RS20205 ENOG4105C1J atp-dependent rna helicase GPY24_RS20210 ENOG4105K63 Thioredoxin GPY24_RS20215 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GPY24_RS20225 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GPY24_RS20235 ENOG4107QK7 reductase GPY24_RS20290 ENOG4105ECF c-methyltransferase GPY24_RS20295 ENOG41076E6 Uroporphyrinogen-III Synthase GPY24_RS20300 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GPY24_RS20305 ENOG4107T0K Adenylate cyclase GPY24_RS20310 ENOG4105XQ6 frataxin-like protein GPY24_RS20325 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GPY24_RS20335 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY24_RS20340 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GPY24_RS20350 ENOG4106IUH DTW domain containing protein GPY24_RS20370 ENOG4105E8V Alpha Beta Hydrolase Fold protein GPY24_RS20375 ENOG410829K Lysine exporter protein (Lyse ygga) GPY24_RS20380 ENOG4105D58 Diguanylate phosphodiesterase GPY24_RS20385 ENOG4105MEV Acyl-transferase GPY24_RS20405 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GPY24_RS20415 ENOG4106H78 methyltransferase GPY24_RS20425 ENOG4105CAK Cell division ATP-binding protein ftsE GPY24_RS20430 ENOG4105CRP Part of the ABC transporter FtsEX involved in GPY24_RS20440 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPY24_RS20445 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GPY24_RS20450 ENOG4105X6C Flagellar basal body-associated protein FliL GPY24_RS20455 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GPY24_RS20475 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GPY24_RS20480 ENOG4105VEJ Heat shock protein GPY24_RS20485 ENOG4108XKW General secretion pathway protein C GPY24_RS20495 ENOG4107QHF type ii secretion system protein e GPY24_RS20505 ENOG4108VAU general secretion pathway protein G GPY24_RS20510 ENOG4105VWV general secretion pathway protein h GPY24_RS20515 ENOG4105X5Z General secretion pathway protein I GPY24_RS20520 ENOG4108WWZ General secretion pathway protein J GPY24_RS20525 ENOG4108RTD type II secretion system protein K GPY24_RS20530 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) GPY24_RS20535 ENOG4105U1E general secretion pathway protein M GPY24_RS20540 ENOG4105PIC general secretion pathway protein N GPY24_RS20550 ENOG4107RK2 ADP-ribose diphosphatase NudE GPY24_RS20555 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) GPY24_RS20560 ENOG4105MJ2 Competence protein GPY24_RS20575 ENOG4105BZM domain protein GPY24_RS20580 ENOG4108RRZ Transcription elongation factor GreB GPY24_RS20595 ENOG410625E GPY24_RS20600 ENOG4106A3M Cytochrome p-450 GPY24_RS20605 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY24_RS20615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY24_RS20625 ENOG4105C2W permease GPY24_RS20635 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GPY24_RS20640 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY24_RS20645 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GPY24_RS20650 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GPY24_RS20665 ENOG4109015 Biopolymer transport protein exbD tolR GPY24_RS20690 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GPY24_RS20695 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPY24_RS20710 ENOG4108JQ7 (ABC) transporter GPY24_RS20725 ENOG4105JIM Phosphatidylserine synthase GPY24_RS20735 ENOG4105D4A Cell wall formation (By similarity) GPY24_RS20740 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GPY24_RS20745 ENOG4105CS9 pantothenic acid kinase GPY24_RS20780 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GPY24_RS20785 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GPY24_RS20790 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GPY24_RS20795 ENOG4108VZM 50s ribosomal protein L10 GPY24_RS20800 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GPY24_RS20805 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY24_RS20825 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GPY24_RS20830 ENOG4108RG0 uracil-dna glycosylase GPY24_RS20835 ENOG4105C5I Dehydrogenase GPY24_RS20840 ENOG4105R2J Conserved Protein GPY24_RS20860 ENOG4105C12 Phosphoribosylglycinamide synthetase GPY24_RS20865 ENOG4105DC1 bifunctional purine biosynthesis protein purh GPY24_RS20875 ENOG4105W1Y Transcriptional regulator GPY24_RS20895 ENOG4107R3N Filamentation induced by cAMP protein fic GPY24_RS20900 ENOG4105FDP GntR family transcriptional regulator GPY24_RS20905 ENOG4105CI1 PTS System GPY24_RS20925 ENOG4105EKX Restriction modification system DNA (Specificity GPY24_RS20930 ENOG4105CVR type I restriction-modification system GPY24_RS20960 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GPY24_RS20965 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY24_RS20975 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GPY24_RS20980 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GPY24_RS20985 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GPY24_RS20995 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY24_RS21015 ENOG4105D8G Major Facilitator superfamily GPY24_RS21020 ENOG4105BZU Histidine kinase GPY24_RS21025 ENOG4107QN1 sodium solute GPY24_RS21035 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GPY24_RS21050 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY24_RS21065 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GPY24_RS21070 ENOG4105E0F Histidine kinase GPY24_RS21075 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY24_RS21090 ENOG4105CTQ phosphohexokinase GPY24_RS21100 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY24_RS21105 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY24_RS21125 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY24_RS21135 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY24_RS21140 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY24_RS21165 ENOG41062JF Transcriptional regulator GPY24_RS21185 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GPY24_RS21190 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GPY24_RS21195 ENOG4107YZP Rhodanese domain protein GPY24_RS21200 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GPY24_RS21215 ENOG4105DJ4 phosphatidylserine decarboxylase GPY24_RS21220 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GPY24_RS21225 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GPY24_RS21305 ENOG4105K8N protein family UPF0079, ATPase GPY24_RS21320 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GPY24_RS21325 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GPY24_RS21330 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GPY24_RS21335 ENOG4107QJR hflk protein GPY24_RS21340 ENOG4105EPW hflc protein GPY24_RS21355 ENOG4108UV7 flagellar protein motX GPY24_RS21365 ENOG4105KPV Transcriptional regulator GPY24_RS21370 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GPY24_RS21375 ENOG4105C2N RNA methyltransferase TrmH family group 3 GPY24_RS21380 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY24_RS21400 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase GPY24_RS21430 ENOG4107RYR Transcriptional regulator, Crp Fnr family GPY24_RS21435 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GPY24_RS21440 ENOG4105YP7 UPF0270 protein GPY24_RS21445 ENOG4105DNZ Alpha Beta Hydrolase GPY24_RS21455 ENOG4105C5H ABC transporter GPY24_RS21460 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPY24_RS21475 ENOG4108YZY peptidylprolyl cis-trans isomerase GPY24_RS21480 ENOG4105D44 asparaginase GPY24_RS21485 ENOG41069P5 Protein slyX homolog GPY24_RS21500 ENOG4105WWK YheO domain protein GPY24_RS21510 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPY24_RS21520 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GPY24_RS21525 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GPY24_RS21540 ENOG4105W53 bacterioferritin-associated ferredoxin GPY24_RS21545 ENOG4108UQY Iron-storage protein GPY24_RS21550 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GPY24_RS21555 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GPY24_RS21560 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GPY24_RS21565 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GPY24_RS21575 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GPY24_RS21580 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GPY24_RS21585 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GPY24_RS21590 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GPY24_RS21595 ENOG41083MP 50s ribosomal protein l29 GPY24_RS21600 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GPY24_RS21605 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GPY24_RS21610 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GPY24_RS21615 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GPY24_RS21620 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GPY24_RS21625 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GPY24_RS21630 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GPY24_RS21635 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GPY24_RS21640 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GPY24_RS21645 ENOG4105VPB 50S ribosomal protein L30 GPY24_RS21655 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GPY24_RS21665 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GPY24_RS21670 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GPY24_RS21675 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GPY24_RS21680 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY24_RS21685 ENOG4108ZT0 50S ribosomal protein l17 GPY24_RS21690 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY24_RS21700 ENOG4105DFI Membrane GPY24_RS21720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY24_RS21725 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GPY24_RS21740 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) GPY24_RS21760 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY24_RS21775 ENOG4108UUE Transcriptional regulator GPY24_RS21790 ENOG4105CFU surface antigen GPY24_RS21800 ENOG41066HZ AIG2-like family GPY24_RS21805 ENOG4105F0N pyrophosphate phospho-hydrolase GPY24_RS21810 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GPY24_RS21815 ENOG4105DFU Cell wall formation (By similarity) GPY24_RS21820 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GPY24_RS21825 ENOG4105DP9 ABC transporter GPY24_RS21830 ENOG4106SMU thiamine transporter membrane protein GPY24_RS21835 ENOG4107T0D ABC, transporter GPY24_RS21845 ENOG4105CMS peptidase U62, modulator of DNA gyrase GPY24_RS21850 ENOG4105CJW magnesium transporter GPY24_RS21855 ENOG41080Z8 PHOSPHOCARRIER protein GPY24_RS21870 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GPY24_RS21875 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY24_RS21880 ENOG4108IUZ ABC transporter GPY24_RS21895 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GPY24_RS21900 ENOG4105C2X Arabinose 5-phosphate isomerase GPY24_RS21910 ENOG4105DHJ ABC, transporter GPY24_RS21915 ENOG4105CY3 ABC transporter, permease GPY24_RS21925 ENOG4105E3I toluene tolerance GPY24_RS21935 ENOG4105VFK BolA family GPY24_RS21945 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GPY24_RS21950 ENOG41081QV Universal stress protein GPY24_RS21980 ENOG4105EAH synthase GPY24_RS21985 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GPY24_RS21990 ENOG4105K46 50S ribosomal protein l27 GPY24_RS22000 ENOG4105DWK Membrane GPY24_RS22005 ENOG4107XM3 UPF0442 protein GPY24_RS22015 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GPY24_RS22020 ENOG4105NWN ApaG protein GPY24_RS22030 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GPY24_RS22035 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GPY24_RS22040 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GPY24_RS22045 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GPY24_RS22070 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GPY24_RS22075 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GPY24_RS22090 ENOG41064T2 transcriptional regulator, lysR family GPY24_RS22095 ENOG4108IQE Amp-dependent synthetase and ligase GPY24_RS22105 ENOG4108ZP8 Acetolactate synthase small subunit GPY24_RS22115 ENOG4108PVQ transcriptional regulator GPY24_RS22120 ENOG4105CA9 Pyruvate kinase GPY24_RS22125 ENOG410804X Transcriptional regulator GPY24_RS22135 ENOG4105E61 Mannitol repressor protein GPY24_RS22140 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GPY24_RS22145 ENOG4105CTS PTS system mannitol-specific GPY24_RS22165 ENOG4105CAF HipA N-terminal domain protein GPY24_RS22190 ENOG4105KTH gatB Yqey GPY24_RS22195 ENOG4105VCC 30S ribosomal protein S21 GPY24_RS22200 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY24_RS22210 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GPY24_RS22215 ENOG4107ZVW dihydroneopterin aldolase GPY24_RS22220 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY24_RS22225 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GPY24_RS22240 ENOG4106MWK domain protein GPY24_RS22245 ENOG4105CJ3 phosphate transporter GPY24_RS22250 ENOG4107IX6 phosphate transport regulator GPY24_RS22265 ENOG4105C8Q Methyl-accepting chemotaxis GPY24_RS22275 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GPY24_RS22280 ENOG4105DFG type I secretion outer membrane protein GPY24_RS22285 ENOG41087AY ADP-Ribose pyrophosphatase GPY24_RS22290 ENOG4108SX3 cytoplasmic protein GPY24_RS22295 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GPY24_RS22305 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY24_RS22310 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY24_RS22320 ENOG4105C0H protease GPY24_RS22330 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GPY24_RS22335 ENOG4105D6Z AFG1 family ATPase GPY24_RS22345 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GPY24_RS22350 ENOG4108UJD 30S ribosomal protein S9 GPY24_RS22355 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY24_RS22360 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY24_RS22365 ENOG4105EIX cytochrome c1 GPY24_RS22370 ENOG4107MKT Stringent starvation protein a GPY24_RS22375 ENOG4105KB2 stringent starvation protein b GPY24_RS22380 ENOG4105W4M Transport-associated protein GPY24_RS22390 ENOG41082RQ UPF0102 protein GPY24_RS22400 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GPY24_RS22410 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GPY24_RS22420 ENOG4105CJN penicillin-binding protein GPY24_RS22425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GPY24_RS22440 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GPY24_RS22450 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GPY24_RS22455 ENOG4105DFU Cell wall formation (By similarity) GPY24_RS22460 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GPY24_RS22465 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GPY24_RS22470 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GPY24_RS22475 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY24_RS22485 ENOG4105M6F mutator MutT protein GPY24_RS22490 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GPY24_RS22495 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GPY24_RS22505 ENOG4105EJ9 Membrane GPY24_RS22510 ENOG4105VP0 transcriptional regulator, lysR family GPY24_RS22525 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GPY24_RS22540 ENOG4105BZ8 glutamate synthase GPY24_RS22560 ENOG4105N5T Radical SAM Protein GPY24_RS22570 ENOG4105BZU Histidine kinase GPY24_RS22580 ENOG41065U4 response regulator GPY24_RS22595 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY24_RS22610 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GPY24_RS22615 ENOG4105D98 threonine synthase GPY24_RS22620 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GPY24_RS22630 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GPY24_RS22645 ENOG4105BZG amino acid carrier protein GPY24_RS22660 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GPY24_RS22665 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPY24_RS22670 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GPY24_RS22675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY24_RS22680 ENOG4105T95 Thiol disulfide interChange protein GPY24_RS22700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY24_RS22710 ENOG4105CPC Aldo Keto reductase GPY24_RS22720 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GPY24_RS22725 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)