locus-tag	class	description
FR741_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FR741_RS00020	COG1126	abc transporter atp-binding protein
FR741_RS00030	COG0594	ribonuclease P activity
FR741_RS00040	COG0706	membrane insertase activity
FR741_RS00050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FR741_RS00055	COG0445	tRNA wobble uridine modification
FR741_RS00060	COG0357	Ribosomal RNA small subunit methyltransferase G
FR741_RS00065	COG1192	Involved in chromosome partitioning
FR741_RS00070	COG1475	DNA binding
FR741_RS00075	COG3312	ion transport
FR741_RS00080	COG0356	it plays a direct role in the translocation of protons across the membrane
FR741_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FR741_RS00095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FR741_RS00100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FR741_RS00105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FR741_RS00110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FR741_RS00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FR741_RS00125	COG0765	amino acid transport
FR741_RS00135	COG2814	Major facilitator Superfamily
FR741_RS00140	COG0583	DNA-binding transcription factor activity
FR741_RS00150	COG0129	dihydroxy-acid dehydratase activity
FR741_RS00155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FR741_RS00160	COG3978	acetolactate synthase activity
FR741_RS00170	COG0606	chelatase, subunit chli
FR741_RS00180	COG0204	Acyl-transferase
FR741_RS00185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR741_RS00190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FR741_RS00200	COG3084	Protein conserved in bacteria
FR741_RS00210	COG4326	sporulation control protein
FR741_RS00215	COG1272	protein, Hemolysin III
FR741_RS00225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR741_RS00230	COG0569	domain protein
FR741_RS00235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FR741_RS00235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FR741_RS00240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FR741_RS00245	COG0242	peptide deformylase activity
FR741_RS00255	COG0758	DNA mediated transformation
FR741_RS00260	COG2922	Belongs to the Smg family
FR741_RS00265	COG0551	DNA topoisomerase type I activity
FR741_RS00270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FR741_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FR741_RS00280	COG0009	L-threonylcarbamoyladenylate synthase
FR741_RS00285	COG0408	coproporphyrinogen oxidase activity
FR741_RS00290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FR741_RS00300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FR741_RS00350	COG2132	Multicopper oxidase
FR741_RS00355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FR741_RS00370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FR741_RS00390	COG0006	proline dipeptidase activity
FR741_RS00390	COG0006	proline dipeptidase activity
FR741_RS00420	COG3220	belongs to the UPF0276 family
FR741_RS00430	COG0210	DNA helicase
FR741_RS00435	COG0405	Gamma-glutamyltransferase
FR741_RS00440	COG1280	lysine exporter protein (LysE YggA)
FR741_RS00450	COG2962	Rard protein
FR741_RS00455	COG0514	ATP-dependent DNA helicase (RecQ)
FR741_RS00465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FR741_RS00470	COG0248	Ppx GppA phosphatase
FR741_RS00475	COG0513	Belongs to the DEAD box helicase family
FR741_RS00480	COG3118	belongs to the thioredoxin family
FR741_RS00495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FR741_RS00500	COG0633	Ferredoxin
FR741_RS00540	COG3071	HemY protein
FR741_RS00545	COG2959	enzyme of heme biosynthesis
FR741_RS00550	COG1587	Uroporphyrinogen-III synthase
FR741_RS00555	COG0181	hydroxymethylbilane synthase activity
FR741_RS00560	COG3072	Adenylate cyclase
FR741_RS00565	COG1965	Belongs to the frataxin family
FR741_RS00575	COG0019	diaminopimelate decarboxylase activity
FR741_RS00580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FR741_RS00590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FR741_RS00595	COG1011	Hydrolase
FR741_RS00600	COG2200	EAL domain
FR741_RS00600	COG3287	FIST C domain
FR741_RS00600	COG2199	diguanylate cyclase activity
FR741_RS00620	COG0561	phosphatase activity
FR741_RS00625	COG2267	carboxylic ester hydrolase activity
FR741_RS00630	COG1280	lysine exporter protein (LysE YggA)
FR741_RS00635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FR741_RS00640	COG0640	Transcriptional regulator
FR741_RS00645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FR741_RS00685	COG2095	MarC family integral membrane protein
FR741_RS00695	COG0742	ribosomal rna small subunit methyltransferase
FR741_RS00700	COG0552	protein localization to endoplasmic reticulum
FR741_RS00705	COG2884	Cell division ATP-binding protein ftsE
FR741_RS00710	COG2177	Part of the ABC transporter FtsEX involved in
FR741_RS00720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR741_RS00725	COG0705	Rhomboid family
FR741_RS00730	COG1580	Controls the rotational direction of flagella during chemotaxis
FR741_RS00735	COG3161	chorismate lyase activity
FR741_RS00740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FR741_RS00745	COG2937	Belongs to the GPAT DAPAT family
FR741_RS00750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FR741_RS00755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FR741_RS00760	COG0534	Mate efflux family protein
FR741_RS00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR741_RS00785	COG4206	TonB-dependent receptor
FR741_RS00850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR741_RS00860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FR741_RS00865	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FR741_RS00865	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FR741_RS00895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FR741_RS00900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FR741_RS00905	COG0250	Participates in transcription elongation, termination and antitermination
FR741_RS00920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FR741_RS00925	COG0222	ribosome binding
FR741_RS00930	COG0085	RNA polymerase activity
FR741_RS00935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FR741_RS00940	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FR741_RS00945	COG2816	NAD+ diphosphatase activity
FR741_RS00950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FR741_RS00955	COG1573	uracil-dna glycosylase
FR741_RS00965	COG3068	Protein conserved in bacteria
FR741_RS00970	COG1253	flavin adenine dinucleotide binding
FR741_RS00985	COG0151	Belongs to the GarS family
FR741_RS00990	COG0138	bifunctional purine biosynthesis protein purh
FR741_RS00995	COG0789	Transcriptional regulator
FR741_RS01000	COG3710	Transcriptional regulator
FR741_RS01010	COG0531	amino acid
FR741_RS01015	COG1982	Orn Lys Arg decarboxylase major
FR741_RS01070	COG0488	(ABC) transporter
FR741_RS01080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FR741_RS01085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR741_RS01090	COG2264	protein methyltransferase activity
FR741_RS01095	COG0439	Biotin carboxylase
FR741_RS01100	COG0511	ligase activity, forming carbon-carbon bonds
FR741_RS01105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FR741_RS01110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR741_RS01125	COG2814	Major facilitator Superfamily
FR741_RS01150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR741_RS01160	COG3263	regulation of cellular component size
FR741_RS01170	COG4232	protein-disulfide reductase activity
FR741_RS01175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FR741_RS01180	COG1027	Aspartate ammonia-lyase
FR741_RS01185	COG3030	protein affecting phage T7 exclusion by the F plasmid
FR741_RS01190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FR741_RS01200	COG2205	protein histidine kinase activity
FR741_RS01205	COG0745	RESPONSE REGULATOR receiver
FR741_RS01210	COG3678	ATP-independent chaperone mediated protein folding
FR741_RS01215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FR741_RS01220	COG0205	6-phosphofructokinase activity
FR741_RS01225	COG0534	Mate efflux family protein
FR741_RS01235	COG0459	protein refolding
FR741_RS01245	COG1285	pathogenesis
FR741_RS01250	COG1509	lysine 2,3-aminomutase activity
FR741_RS01270	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FR741_RS01275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FR741_RS01280	COG1053	succinate dehydrogenase
FR741_RS01285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FR741_RS01305	COG4942	peptidase
FR741_RS01310	COG1045	serine acetyltransferase
FR741_RS01315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FR741_RS01320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FR741_RS01325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR741_RS01330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FR741_RS01340	COG3273	potassium ion transport
FR741_RS01340	COG0471	metal ion transport
FR741_RS01345	COG0688	phosphatidylethanolamine metabolic process
FR741_RS01350	COG1162	GTPase activity
FR741_RS01355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FR741_RS01420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FR741_RS01425	COG0802	atpase or kinase
FR741_RS01435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FR741_RS01440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FR741_RS01450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FR741_RS01455	COG0330	HflC and HflK could
FR741_RS01460	COG0330	HflC and HflK could
FR741_RS01465	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FR741_RS01470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FR741_RS01475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FR741_RS01480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR741_RS01480	COG1017	nitric oxide dioxygenase activity
FR741_RS01485	COG1959	2 iron, 2 sulfur cluster binding
FR741_RS01490	COG0557	exoribonuclease II activity
FR741_RS01495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR741_RS01500	COG0546	phosphoglycolate phosphatase activity
FR741_RS01505	COG0180	Tryptophanyl-tRNA synthetase
FR741_RS01520	COG0512	Glutamine amidotransferase of anthranilate synthase
FR741_RS01525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FR741_RS01545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR741_RS01550	COG3954	Phosphoribulokinase
FR741_RS01555	COG3089	Belongs to the UPF0270 family
FR741_RS01560	COG0429	hydrolase of the alpha beta-hydrolase fold
FR741_RS01570	COG0488	(ABC) transporter
FR741_RS01575	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR741_RS01590	COG1047	Peptidyl-prolyl cis-trans
FR741_RS01595	COG1446	asparaginase
FR741_RS01610	COG0545	Peptidyl-prolyl cis-trans isomerase
FR741_RS01615	COG2964	Protein conserved in bacteria
FR741_RS01620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FR741_RS01625	COG2923	Belongs to the DsrF TusC family
FR741_RS01630	COG2168	tRNA wobble position uridine thiolation
FR741_RS01645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FR741_RS01650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FR741_RS01655	COG2906	2 iron, 2 sulfur cluster binding
FR741_RS01665	COG0281	malic enzyme
FR741_RS01675	COG0626	cystathionine gamma-synthase activity
FR741_RS01680	COG0460	homoserine dehydrogenase
FR741_RS01680	COG0527	aspartate kinase activity
FR741_RS01685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FR741_RS01695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FR741_RS01705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FR741_RS01715	COG0137	argininosuccinate synthase activity
FR741_RS01720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FR741_RS01720	COG0165	Argininosuccinate lyase
FR741_RS01735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FR741_RS01735	COG0678	peroxiredoxin activity
FR741_RS01745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FR741_RS01775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FR741_RS01780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FR741_RS01790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FR741_RS01795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FR741_RS01800	COG0360	Binds together with S18 to 16S ribosomal RNA
FR741_RS01805	COG2965	DNA replication, synthesis of RNA primer
FR741_RS01830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FR741_RS01835	COG0432	Pfam Uncharacterised protein family UPF0047
FR741_RS01840	COG0166	Belongs to the GPI family
FR741_RS01850	COG0735	belongs to the Fur family
FR741_RS01855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR741_RS01875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FR741_RS01880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR741_RS01885	COG0175	sulfate reduction
FR741_RS01945	COG0646	methionine synthase
FR741_RS01945	COG1410	methionine synthase
FR741_RS01950	COG0527	aspartate kinase activity
FR741_RS01955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FR741_RS01965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FR741_RS01980	COG0629	single-stranded DNA binding
FR741_RS02010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR741_RS02040	COG3550	peptidyl-serine autophosphorylation
FR741_RS02075	COG2199	diguanylate cyclase activity
FR741_RS02075	COG2200	EAL domain
FR741_RS02095	COG1450	Type ii and iii secretion system protein
FR741_RS02100	COG3267	Type II secretory pathway component ExeA
FR741_RS02100	COG3409	Peptidoglycan-binding domain 1 protein
FR741_RS02110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR741_RS02115	COG1459	type II secretion system
FR741_RS02160	COG1077	Cell shape determining protein MreB Mrl
FR741_RS02165	COG1792	Involved in formation and maintenance of cell shape
FR741_RS02170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FR741_RS02175	COG0424	maF-like protein
FR741_RS02180	COG1530	ribonuclease E activity
FR741_RS02185	COG3164	Protein of unknown function
FR741_RS02190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR741_RS02195	COG0312	modulator of DNA gyrase
FR741_RS02200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FR741_RS02205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FR741_RS02215	COG0564	pseudouridine synthase activity
FR741_RS02220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FR741_RS02225	COG3028	Belongs to the UPF0307 family
FR741_RS02230	COG0312	modulator of DNA gyrase
FR741_RS02235	COG2239	Acts as a magnesium transporter
FR741_RS02240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS02245	COG1660	Displays ATPase and GTPase activities
FR741_RS02250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS02255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FR741_RS02265	COG1137	ATPase activity
FR741_RS02270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FR741_RS02280	COG0517	IMP dehydrogenase activity
FR741_RS02280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FR741_RS02290	COG1127	ABC transporter
FR741_RS02295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FR741_RS02300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FR741_RS02305	COG2854	intermembrane phospholipid transfer
FR741_RS02315	COG5007	Belongs to the BolA IbaG family
FR741_RS02325	COG0204	Acyl-transferase
FR741_RS02330	COG0251	oxidation-reduction process
FR741_RS02335	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FR741_RS02340	COG0540	Belongs to the ATCase OTCase family
FR741_RS02380	COG0525	valine-tRNA ligase activity
FR741_RS02385	COG2927	DNA polymerase III (CHI subunit)
FR741_RS02395	COG0795	lipopolysaccharide-transporting ATPase activity
FR741_RS02400	COG0795	lipopolysaccharide-transporting ATPase activity
FR741_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS02425	COG0726	polysaccharide deacetylase
FR741_RS02435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FR741_RS02440	COG1447	Phosphotransferase system cellobiose-specific component IIA
FR741_RS02445	COG1486	melibiose metabolic process
FR741_RS02450	COG3394	polysaccharide catabolic process
FR741_RS02460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FR741_RS02505	COG1012	belongs to the aldehyde dehydrogenase family
FR741_RS02580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FR741_RS02590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FR741_RS02600	COG2066	Belongs to the glutaminase family
FR741_RS02605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FR741_RS02610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FR741_RS02620	COG1872	DUF167
FR741_RS02625	COG0762	integral membrane protein
FR741_RS02630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FR741_RS02635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FR741_RS02650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FR741_RS02655	COG1678	Uncharacterized ACR, COG1678
FR741_RS02660	COG0189	ligase activity
FR741_RS02665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FR741_RS02670	COG2356	endonuclease I
FR741_RS02685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FR741_RS02690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FR741_RS02695	COG0583	DNA-binding transcription factor activity
FR741_RS02700	COG4771	TonB-dependent receptor
FR741_RS02710	COG0126	phosphoglycerate kinase activity
FR741_RS02715	COG0191	fructose-bisphosphate aldolase activity
FR741_RS02720	COG0668	transmembrane transport
FR741_RS02735	COG0583	DNA-binding transcription factor activity
FR741_RS02745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FR741_RS02750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FR741_RS02755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FR741_RS02765	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FR741_RS02770	COG3079	Belongs to the UPF0149 family
FR741_RS02775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR741_RS02780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR741_RS02795	COG0354	folic acid binding
FR741_RS02800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FR741_RS02805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FR741_RS02810	COG1595	DNA-templated transcription, initiation
FR741_RS02825	COG3086	response to oxidative stress
FR741_RS02830	COG0481	GTPase activity
FR741_RS02835	COG0681	Belongs to the peptidase S26 family
FR741_RS02845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FR741_RS02850	COG1381	Involved in DNA repair and RecF pathway recombination
FR741_RS02855	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FR741_RS02860	COG0736	holo-[acyl-carrier-protein] synthase activity
FR741_RS02870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FR741_RS02875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR741_RS02880	COG3956	TIGRFAM MazG family protein
FR741_RS02885	COG0504	CTP synthase activity
FR741_RS02890	COG0148	phosphopyruvate hydratase activity
FR741_RS02895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FR741_RS02900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FR741_RS02905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FR741_RS02915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FR741_RS02920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FR741_RS02930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FR741_RS02935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FR741_RS02940	COG1546	Belongs to the CinA family
FR741_RS02945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FR741_RS02950	COG2137	regulation of response to DNA damage stimulus
FR741_RS02955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FR741_RS02960	COG0527	aspartate kinase activity
FR741_RS03020	COG3630	sodium ion export across plasma membrane
FR741_RS03025	COG5016	pyruvate
FR741_RS03025	COG0511	ligase activity, forming carbon-carbon bonds
FR741_RS03030	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FR741_RS03040	COG1238	metal cluster binding
FR741_RS03045	COG0612	Peptidase, M16
FR741_RS03060	COG1854	S-ribosylhomocysteine lyase activity
FR741_RS03065	COG4536	flavin adenine dinucleotide binding
FR741_RS03070	COG4137	Cytochrome C assembly protein
FR741_RS03075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FR741_RS03080	COG0228	four-way junction DNA binding
FR741_RS03085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FR741_RS03100	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FR741_RS03105	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FR741_RS03110	COG0237	dephospho-CoA kinase activity
FR741_RS03120	COG1459	type II secretion system
FR741_RS03125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR741_RS03130	COG4969	Belongs to the N-Me-Phe pilin family
FR741_RS03135	COG0157	Belongs to the NadC ModD family
FR741_RS03145	COG2186	Transcriptional regulator
FR741_RS03150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FR741_RS03155	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR741_RS03160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR741_RS03175	COG0288	reversible hydration of carbon dioxide
FR741_RS03180	COG0659	secondary active sulfate transmembrane transporter activity
FR741_RS03185	COG1131	(ABC) transporter
FR741_RS03190	COG0842	Transport permease protein
FR741_RS03195	COG1560	Kdo2-lipid A biosynthetic process
FR741_RS03200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FR741_RS03205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FR741_RS03210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FR741_RS03220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR741_RS03230	COG1489	DNA binding
FR741_RS03235	COG1643	Atp-dependent helicase
FR741_RS03240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FR741_RS03245	COG1752	Esterase of the alpha-beta hydrolase superfamily
FR741_RS03250	COG1049	propionate catabolic process, 2-methylcitrate cycle
FR741_RS03255	COG3112	Uncharacterised protein family (UPF0231)
FR741_RS03260	COG0347	Belongs to the P(II) protein family
FR741_RS03265	COG0004	ammonium transporteR
FR741_RS03270	COG1840	ABC-type Fe3 transport system, periplasmic component
FR741_RS03280	COG3842	ATPase activity
FR741_RS03285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR741_RS03300	COG2971	BadF BadG BcrA BcrD
FR741_RS03310	COG4608	Belongs to the ABC transporter superfamily
FR741_RS03315	COG0444	Belongs to the ABC transporter superfamily
FR741_RS03330	COG0747	negative chemotaxis
FR741_RS03335	COG2205	protein histidine kinase activity
FR741_RS03335	COG0784	Response regulator, receiver
FR741_RS03345	COG0628	permease
FR741_RS03350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FR741_RS03370	COG0739	heme binding
FR741_RS03375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FR741_RS03385	COG2027	D-alanyl-D-alanine carboxypeptidase
FR741_RS03390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR741_RS03395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR741_RS03400	COG1534	Rna-binding protein
FR741_RS03405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FR741_RS03410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FR741_RS03415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FR741_RS03420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR741_RS03425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FR741_RS03440	COG0779	Required for maturation of 30S ribosomal subunits
FR741_RS03445	COG0195	Participates in both transcription termination and antitermination
FR741_RS03450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FR741_RS03455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FR741_RS03460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FR741_RS03465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FR741_RS03470	COG1185	polyribonucleotide nucleotidyltransferase activity
FR741_RS03485	COG0534	Mate efflux family protein
FR741_RS03490	COG0826	peptidase U32
FR741_RS03495	COG0826	peptidase U32
FR741_RS03505	COG3154	lipid carrier protein
FR741_RS03510	COG3153	acetyltransferase
FR741_RS03530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FR741_RS03540	COG0084	hydrolase, TatD family'
FR741_RS03545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FR741_RS03555	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FR741_RS03560	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FR741_RS03565	COG0813	purine-nucleoside phosphorylase activity
FR741_RS03575	COG0560	Phosphoserine phosphatase
FR741_RS03585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FR741_RS03590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FR741_RS03595	COG0583	DNA-binding transcription factor activity
FR741_RS03605	COG1022	Amp-dependent synthetase and ligase
FR741_RS03610	COG2169	Transcriptional regulator
FR741_RS03635	COG4964	Belongs to the GSP D family
FR741_RS03695	COG0583	DNA-binding transcription factor activity
FR741_RS03700	COG0531	amino acid
FR741_RS03705	COG2731	YhcH YjgK YiaL family protein
FR741_RS03710	COG3250	beta-galactosidase activity
FR741_RS03715	COG1609	Transcriptional regulator
FR741_RS03720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FR741_RS03730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FR741_RS03735	COG2017	converts alpha-aldose to the beta-anomer
FR741_RS03740	COG1609	Transcriptional regulator
FR741_RS03750	COG2211	Major facilitator Superfamily
FR741_RS03755	COG1609	Transcriptional regulator
FR741_RS03760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR741_RS03780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FR741_RS03785	COG1349	DNA-binding transcription factor activity
FR741_RS03790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FR741_RS03795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FR741_RS03800	COG2271	Major facilitator Superfamily
FR741_RS03805	COG0584	glycerophosphoryl diester phosphodiesterase
FR741_RS03810	COG2171	N-acyltransferase activity
FR741_RS03815	COG3141	response to X-ray
FR741_RS03835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FR741_RS03840	COG1074	ATP-dependent DNA helicase activity
FR741_RS03845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR741_RS03855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FR741_RS03855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FR741_RS03865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FR741_RS03870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FR741_RS03875	COG2166	iron-sulfur cluster assembly
FR741_RS03880	COG3706	GGDEF domain
FR741_RS03885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FR741_RS03890	COG0693	protein deglycase activity
FR741_RS03895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FR741_RS03900	COG3248	Nucleoside-binding outer membrane protein
FR741_RS03915	COG1595	DNA-templated transcription, initiation
FR741_RS03935	COG3056	Lipoprotein
FR741_RS03940	COG2813	Specifically methylates the guanine in position
FR741_RS03945	COG0271	Belongs to the BolA IbaG family
FR741_RS03950	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR741_RS03955	COG1805	sodium ion transport
FR741_RS03960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR741_RS03965	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR741_RS03970	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR741_RS03975	COG2871	sodium ion transport
FR741_RS03980	COG1477	protein flavinylation
FR741_RS03995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR741_RS04000	COG0514	ATP-dependent DNA helicase (RecQ)
FR741_RS04020	COG0733	neurotransmitter:sodium symporter activity
FR741_RS04040	COG0442	prolyl-tRNA aminoacylation
FR741_RS04045	COG1720	tRNA m6t6A37 methyltransferase activity
FR741_RS04050	COG0254	rRNA binding
FR741_RS04060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FR741_RS04085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FR741_RS04090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FR741_RS04125	COG0564	pseudouridine synthase activity
FR741_RS04135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FR741_RS04140	COG0024	Methionine aminopeptidase
FR741_RS04145	COG0052	Belongs to the universal ribosomal protein uS2 family
FR741_RS04150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FR741_RS04155	COG0528	UMP kinase activity
FR741_RS04160	COG0233	cytoplasmic translational termination
FR741_RS04165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FR741_RS04170	COG0575	Belongs to the CDS family
FR741_RS04175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FR741_RS04180	COG0750	zinc metalloprotease
FR741_RS04190	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FR741_RS04195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR741_RS04205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR741_RS04210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR741_RS04220	COG0587	DNA-directed DNA polymerase activity
FR741_RS04225	COG0825	malonyl-CoA metabolic process
FR741_RS04240	COG0347	Belongs to the P(II) protein family
FR741_RS04245	COG3021	interspecies interaction between organisms
FR741_RS04255	COG1388	LysM domain
FR741_RS04255	COG0741	lytic transglycosylase activity
FR741_RS04260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR741_RS04265	COG2226	methyltransferase
FR741_RS04270	COG0328	RNA-DNA hybrid ribonuclease activity
FR741_RS04310	COG1960	acyl-CoA dehydrogenase activity
FR741_RS04320	COG0121	glutamine amidotransferase
FR741_RS04325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FR741_RS04330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FR741_RS04335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FR741_RS04340	COG2233	PERMEase
FR741_RS04360	COG1393	Belongs to the ArsC family
FR741_RS04365	COG4783	chaperone-mediated protein folding
FR741_RS04380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FR741_RS04390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR741_RS04410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FR741_RS04415	COG1393	Belongs to the ArsC family
FR741_RS04440	COG2837	iron assimilation
FR741_RS04445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS04450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS04455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS04460	COG1334	flagellar protein FlaG
FR741_RS04465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FR741_RS04475	COG1516	flagellar protein fliS
FR741_RS04485	COG4191	Histidine kinase
FR741_RS04495	COG1677	Flagellar hook-basal body complex protein FliE
FR741_RS04505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FR741_RS04555	COG1987	bacterial-type flagellum assembly
FR741_RS04595	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FR741_RS04600	COG0643	Histidine kinase
FR741_RS04600	COG2198	Histidine kinase
FR741_RS04600	COG0784	Response regulator, receiver
FR741_RS04605	COG2201	protein-glutamate methylesterase activity
FR741_RS04610	COG1192	Involved in chromosome partitioning
FR741_RS04620	COG0835	chemotaxis
FR741_RS04630	COG4133	protoheme IX ABC transporter activity
FR741_RS04635	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FR741_RS04640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FR741_RS04645	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FR741_RS04650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FR741_RS04655	COG1138	Cytochrome C-type biogenesis protein
FR741_RS04660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FR741_RS04680	COG2067	long-chain fatty acid transport protein
FR741_RS04700	COG0183	Belongs to the thiolase family
FR741_RS04705	COG1024	Enoyl-CoA hydratase
FR741_RS04705	COG1250	3-hydroxyacyl-CoA dehydrogenase
FR741_RS04720	COG2062	phosphohistidine phosphatase, SixA
FR741_RS04725	COG2840	Smr protein MutS2
FR741_RS04730	COG2890	protein-(glutamine-N5) methyltransferase activity
FR741_RS04740	COG2860	membrane
FR741_RS04745	COG3101	peptidyl-lysine hydroxylation
FR741_RS04755	COG0431	NADPH-dependent FMN reductase
FR741_RS04760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FR741_RS04760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR741_RS04765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FR741_RS04770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FR741_RS04775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FR741_RS04785	COG0101	tRNA pseudouridine synthase activity
FR741_RS04790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FR741_RS04795	COG0285	dihydrofolate synthase activity
FR741_RS04800	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FR741_RS04805	COG1286	toxin biosynthetic process
FR741_RS04810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FR741_RS04815	COG0583	DNA-binding transcription factor activity
FR741_RS04820	COG0745	RESPONSE REGULATOR receiver
FR741_RS04825	COG2832	Protein of unknown function (DUF454)
FR741_RS04830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FR741_RS04845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FR741_RS04860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FR741_RS04865	COG0814	amino acid
FR741_RS04870	COG0251	oxidation-reduction process
FR741_RS04875	COG3681	Belongs to the UPF0597 family
FR741_RS04890	COG2261	transglycosylase associated protein
FR741_RS04895	COG2983	Belongs to the UPF0260 family
FR741_RS04900	COG0668	transmembrane transport
FR741_RS04905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FR741_RS04910	COG0346	lactoylglutathione lyase activity
FR741_RS04920	COG1785	Belongs to the alkaline phosphatase family
FR741_RS04935	COG2226	methyltransferase
FR741_RS04950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FR741_RS04955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR741_RS04965	COG3139	Protein of unknown function (DUF1315)
FR741_RS04970	COG0252	asparaginase activity
FR741_RS04975	COG0616	signal peptide processing
FR741_RS04980	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR741_RS04980	COG1902	pentaerythritol trinitrate reductase activity
FR741_RS04990	COG0778	Nitroreductase
FR741_RS04995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FR741_RS05010	COG0123	including yeast histone deacetylase and acetoin utilization protein
FR741_RS05025	COG3082	Protein of unknown function (DUF1414)
FR741_RS05030	COG3081	Nucleoid-associated protein
FR741_RS05045	COG1757	Na H antiporter
FR741_RS05050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FR741_RS05055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR741_RS05060	COG2095	MarC family integral membrane protein
FR741_RS05065	COG1454	alcohol dehydrogenase
FR741_RS05065	COG1012	belongs to the aldehyde dehydrogenase family
FR741_RS05085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FR741_RS05095	COG2056	Na+-H+ antiporter family
FR741_RS05100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FR741_RS05105	COG2885	chlorophyll binding
FR741_RS05115	COG0346	lactoylglutathione lyase activity
FR741_RS05120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FR741_RS05125	COG4660	Part of a membrane complex involved in electron transport
FR741_RS05130	COG4659	FMN binding
FR741_RS05135	COG4658	electron transport chain
FR741_RS05140	COG4656	Part of a membrane complex involved in electron transport
FR741_RS05145	COG2878	Part of a membrane complex involved in electron transport
FR741_RS05150	COG4657	Part of a membrane complex involved in electron transport
FR741_RS05160	COG0556	nucleotide-excision repair
FR741_RS05165	COG2204	response regulator
FR741_RS05170	COG2198	Histidine kinase
FR741_RS05175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FR741_RS05180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FR741_RS05185	COG0521	Mo-molybdopterin cofactor biosynthetic process
FR741_RS05190	COG0315	cyclic pyranopterin monophosphate synthase activity
FR741_RS05195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FR741_RS05200	COG0314	molybdopterin synthase activity
FR741_RS05210	COG0601	transmembrane transport
FR741_RS05215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR741_RS05220	COG0444	Belongs to the ABC transporter superfamily
FR741_RS05230	COG0435	Glutathione S-transferase
FR741_RS05240	COG3174	membrane
FR741_RS05245	COG0280	phosphate acetyltransferase
FR741_RS05245	COG0857	belongs to the CobB CobQ family
FR741_RS05250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FR741_RS05255	COG3092	negative regulation of chromosome organization
FR741_RS05265	COG4120	Belongs to the binding-protein-dependent transport system permease family
FR741_RS05270	COG1122	ATPase activity
FR741_RS05275	COG0366	Alpha amylase catalytic
FR741_RS05280	COG3706	GGDEF domain
FR741_RS05285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR741_RS05290	COG0653	protein targeting
FR741_RS05295	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FR741_RS05300	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FR741_RS05305	COG2186	Transcriptional regulator
FR741_RS05315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR741_RS05315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR741_RS05325	COG0572	uridine kinase
FR741_RS05335	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FR741_RS05340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FR741_RS05345	COG0659	secondary active sulfate transmembrane transporter activity
FR741_RS05350	COG1530	ribonuclease E activity
FR741_RS05355	COG0564	pseudouridine synthase activity
FR741_RS05360	COG0424	maF-like protein
FR741_RS05365	COG1399	metal-binding, possibly nucleic acid-binding protein
FR741_RS05375	COG0416	fatty acid biosynthetic process
FR741_RS05380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FR741_RS05410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FR741_RS05415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FR741_RS05420	COG0470	DNA polymerase III
FR741_RS05425	COG0084	hydrolase, TatD family'
FR741_RS05430	COG1263	PTS System
FR741_RS05430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR741_RS05445	COG0733	neurotransmitter:sodium symporter activity
FR741_RS05460	COG4667	esterase of the alpha-beta hydrolase superfamily
FR741_RS05465	COG0469	pyruvate kinase activity
FR741_RS05470	COG1940	carbohydrate kinase activity
FR741_RS05475	COG0784	Response regulator, receiver
FR741_RS05475	COG0835	chemotaxis
FR741_RS05480	COG0587	DNA-directed DNA polymerase activity
FR741_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS05500	COG0616	signal peptide processing
FR741_RS05505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FR741_RS05510	COG0539	negative regulation of cytoplasmic translation
FR741_RS05520	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FR741_RS05525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FR741_RS05535	COG4166	transmembrane transport
FR741_RS05550	COG3008	intermembrane lipid transfer
FR741_RS05550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FR741_RS05555	COG2995	paraquat-inducible protein a
FR741_RS05560	COG3258	Cytochrome c
FR741_RS05565	COG2863	cytochrome
FR741_RS05600	COG4232	protein-disulfide reductase activity
FR741_RS05605	COG3118	belongs to the thioredoxin family
FR741_RS05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS05645	COG0577	efflux transmembrane transporter activity
FR741_RS05645	COG1136	(ABC) transporter
FR741_RS05655	COG1136	(ABC) transporter
FR741_RS05655	COG0577	efflux transmembrane transporter activity
FR741_RS05710	COG5002	protein histidine kinase activity
FR741_RS05710	COG3850	Histidine kinase
FR741_RS05715	COG0745	RESPONSE REGULATOR receiver
FR741_RS05720	COG0840	transmembrane signaling receptor activity
FR741_RS05735	COG1032	radical SAM domain protein
FR741_RS05740	COG5001	Diguanylate cyclase
FR741_RS05755	COG0583	DNA-binding transcription factor activity
FR741_RS05760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FR741_RS05770	COG2350	Protein conserved in bacteria
FR741_RS05780	COG2917	probably involved in intracellular septation
FR741_RS05800	COG1301	dicarboxylic acid transport
FR741_RS05805	COG0318	PFAM AMP-dependent synthetase and ligase
FR741_RS05810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR741_RS05815	COG0159	tryptophan synthase activity
FR741_RS05825	COG0135	phosphoribosylanthranilate isomerase activity
FR741_RS05825	COG0134	indole-3-glycerol-phosphate synthase activity
FR741_RS05835	COG0512	Glutamine amidotransferase of anthranilate synthase
FR741_RS05840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FR741_RS05850	COG0613	PHP domain protein
FR741_RS05855	COG0009	L-threonylcarbamoyladenylate synthase
FR741_RS05865	COG1187	pseudouridine synthase activity
FR741_RS05885	COG0417	DNA replication proofreading
FR741_RS05890	COG2197	response regulator
FR741_RS05895	COG0322	excinuclease ABC activity
FR741_RS05935	COG0019	diaminopimelate decarboxylase activity
FR741_RS05965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FR741_RS05970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR741_RS05990	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FR741_RS06000	COG0437	4 iron, 4 sulfur cluster binding
FR741_RS06005	COG3301	Polysulphide reductase, NrfD
FR741_RS06010	COG1138	Cytochrome C-type biogenesis protein
FR741_RS06020	COG3088	subunit of a heme lyase
FR741_RS06020	COG4235	cytochrome complex assembly
FR741_RS06030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR741_RS06055	COG2989	Protein conserved in bacteria
FR741_RS06060	COG3108	Peptidase M15
FR741_RS06065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR741_RS06080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FR741_RS06110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR741_RS06115	COG0840	transmembrane signaling receptor activity
FR741_RS06135	COG1448	Aminotransferase
FR741_RS06150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR741_RS06160	COG0017	Asparaginyl-tRNA synthetase
FR741_RS06165	COG0840	transmembrane signaling receptor activity
FR741_RS06170	COG0720	synthase
FR741_RS06180	COG2200	EAL domain
FR741_RS06185	COG1760	l-serine dehydratase
FR741_RS06190	COG0814	amino acid
FR741_RS06195	COG0494	nUDIX hydrolase
FR741_RS06205	COG2205	protein histidine kinase activity
FR741_RS06205	COG0784	Response regulator, receiver
FR741_RS06210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FR741_RS06225	COG3106	COG3106 Predicted ATPase
FR741_RS06230	COG3768	UPF0283 membrane protein
FR741_RS06240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR741_RS06295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FR741_RS06295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FR741_RS06380	COG0582	viral genome integration into host DNA
FR741_RS06720	COG0307	riboflavin synthase, alpha
FR741_RS06780	COG1683	Conserved Protein
FR741_RS06970	COG1619	proteins homologs of microcin C7 resistance protein MccF
FR741_RS07010	COG0346	lactoylglutathione lyase activity
FR741_RS07060	COG0456	acetyltransferase
FR741_RS07060	COG0454	-acetyltransferase
FR741_RS07080	COG0456	acetyltransferase
FR741_RS07155	COG5507	3-demethylubiquinone-9 3-methyltransferase
FR741_RS07160	COG1280	lysine exporter protein (LysE YggA)
FR741_RS07190	COG0583	DNA-binding transcription factor activity
FR741_RS07200	COG1566	PFAM secretion protein HlyD family protein
FR741_RS07215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS07230	COG3290	protein histidine kinase activity
FR741_RS07235	COG4565	transcriptional regulatory protein
FR741_RS07250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FR741_RS07255	COG0363	glucosamine-6-phosphate deaminase activity
FR741_RS07260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FR741_RS07275	COG3284	Transcriptional regulator
FR741_RS07280	COG1012	belongs to the aldehyde dehydrogenase family
FR741_RS07350	COG4669	(LipO)protein
FR741_RS07370	COG3177	Filamentation induced by cAMP protein fic
FR741_RS07400	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS07425	COG4792	protein secretion
FR741_RS07430	COG4791	protein targeting
FR741_RS07435	COG4794	Type iii secretion
FR741_RS07440	COG4790	Type iii secretion
FR741_RS07510	COG0457	Tetratricopeptide repeat
FR741_RS07525	COG2358	TRAP transporter, solute receptor (TAXI family
FR741_RS07530	COG0730	response to heat
FR741_RS07565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FR741_RS07570	COG0372	Belongs to the citrate synthase family
FR741_RS07580	COG2828	Protein conserved in bacteria
FR741_RS07605	COG0561	phosphatase activity
FR741_RS07610	COG0602	queuosine metabolic process
FR741_RS07615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FR741_RS07620	COG3706	GGDEF domain
FR741_RS07670	COG1254	Belongs to the acylphosphatase family
FR741_RS07675	COG2920	part of a sulfur-relay system
FR741_RS07685	COG0670	Belongs to the BI1 family
FR741_RS07690	COG1126	abc transporter atp-binding protein
FR741_RS07695	COG0765	amino acid transport
FR741_RS07700	COG4597	amino acid ABC transporter
FR741_RS07710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR741_RS07720	COG1666	GTP binding
FR741_RS07725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR741_RS07750	COG3008	intermembrane lipid transfer
FR741_RS07755	COG2995	paraquat-inducible protein a
FR741_RS07760	COG1132	(ABC) transporter
FR741_RS07765	COG1956	GAF domain-containing protein
FR741_RS07770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FR741_RS07785	COG0308	aminopeptidase N
FR741_RS07795	COG2902	Dehydrogenase
FR741_RS07800	COG0167	dihydroorotate dehydrogenase activity
FR741_RS07810	COG0116	Belongs to the methyltransferase superfamily
FR741_RS07810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FR741_RS07835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FR741_RS07840	COG1067	ATP-dependent peptidase activity
FR741_RS07845	COG3120	sequence-specific DNA binding
FR741_RS07865	COG0784	Response regulator, receiver
FR741_RS07865	COG2205	protein histidine kinase activity
FR741_RS07880	COG3278	Belongs to the heme-copper respiratory oxidase family
FR741_RS07895	COG2010	Cytochrome c
FR741_RS07905	COG2217	Heavy metal translocating P-type atpase
FR741_RS07920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR741_RS07925	COG0589	response to stress
FR741_RS07950	COG3842	ATPase activity
FR741_RS07960	COG1177	transmembrane transport
FR741_RS07970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FR741_RS07975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FR741_RS07985	COG0004	ammonium transporteR
FR741_RS07990	COG4282	regulation of fungal-type cell wall biogenesis
FR741_RS08010	COG0437	4 iron, 4 sulfur cluster binding
FR741_RS08015	COG0243	molybdopterin cofactor binding
FR741_RS08015	COG3383	formate dehydrogenase (NAD+) activity
FR741_RS08025	COG3381	protein complex oligomerization
FR741_RS08045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FR741_RS08050	COG0488	(ABC) transporter
FR741_RS08055	COG4191	Histidine kinase
FR741_RS08060	COG2204	response regulator
FR741_RS08075	COG3842	ATPase activity
FR741_RS08080	COG0746	molybdenum cofactor guanylyltransferase activity
FR741_RS08095	COG1940	carbohydrate kinase activity
FR741_RS08130	COG0791	NLP P60 protein
FR741_RS08140	COG3706	GGDEF domain
FR741_RS08150	COG3001	Fructosamine kinase
FR741_RS08160	COG0307	riboflavin synthase, alpha
FR741_RS08165	COG0534	Mate efflux family protein
FR741_RS08175	COG1793	dna ligase
FR741_RS08205	COG2204	response regulator
FR741_RS08210	COG0297	glycogen (starch) synthase activity
FR741_RS08215	COG0438	transferase activity, transferring glycosyl groups
FR741_RS08245	COG0438	transferase activity, transferring glycosyl groups
FR741_RS08250	COG1215	transferase activity, transferring glycosyl groups
FR741_RS08255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR741_RS08265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR741_RS08280	COG1643	Atp-dependent helicase
FR741_RS08285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FR741_RS08330	COG0443	Heat shock 70 kDa protein
FR741_RS08335	COG0443	Heat shock 70 kDa protein
FR741_RS08355	COG4968	Prepilin-type N-terminal cleavage methylation domain
FR741_RS08360	COG1132	(ABC) transporter
FR741_RS08365	COG1132	(ABC) transporter
FR741_RS08375	COG4774	siderophore transport
FR741_RS08385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FR741_RS08390	COG1120	ATPase activity
FR741_RS08405	COG0814	amino acid
FR741_RS08415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FR741_RS08425	COG0861	Integral membrane protein TerC family
FR741_RS08435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FR741_RS08440	COG1328	CTP reductase activity
FR741_RS08455	COG3300	MHYT domain
FR741_RS08455	COG5001	Diguanylate cyclase
FR741_RS08465	COG4191	Histidine kinase
FR741_RS08470	COG0471	metal ion transport
FR741_RS08495	COG4702	Belongs to the UPF0303 family
FR741_RS08500	COG0673	inositol 2-dehydrogenase activity
FR741_RS08505	COG1349	DNA-binding transcription factor activity
FR741_RS08520	COG0641	radical SAM
FR741_RS08535	COG3119	arylsulfatase activity
FR741_RS08540	COG0527	aspartate kinase activity
FR741_RS08545	COG0662	Cupin 2, conserved barrel domain protein
FR741_RS08550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR741_RS08555	COG0456	acetyltransferase
FR741_RS08560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR741_RS08580	COG4176	ABC-type proline glycine betaine transport system permease component
FR741_RS08585	COG2113	Glycine betaine
FR741_RS08595	COG1022	Amp-dependent synthetase and ligase
FR741_RS08605	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS08615	COG0745	RESPONSE REGULATOR receiver
FR741_RS08620	COG0642	Histidine kinase
FR741_RS08625	COG1368	sulfuric ester hydrolase activity
FR741_RS08655	COG1115	amino acid carrier protein
FR741_RS08665	COG1280	lysine exporter protein (LysE YggA)
FR741_RS08670	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FR741_RS08675	COG1560	Kdo2-lipid A biosynthetic process
FR741_RS08680	COG0531	amino acid
FR741_RS08695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FR741_RS08700	COG3063	Type IV pilus biogenesis stability protein PilW
FR741_RS08730	COG0110	maltose O-acetyltransferase activity
FR741_RS08745	COG2315	Protein conserved in bacteria
FR741_RS08750	COG1846	Transcriptional regulator
FR741_RS08760	COG2200	EAL domain
FR741_RS08795	COG0625	glutathione transferase activity
FR741_RS08805	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FR741_RS08815	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR741_RS08825	COG0601	transmembrane transport
FR741_RS08830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR741_RS08850	COG3291	Pkd domain containing protein
FR741_RS08865	COG1177	transmembrane transport
FR741_RS08875	COG3842	ATPase activity
FR741_RS08880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR741_RS08885	COG2423	ornithine cyclodeaminase activity
FR741_RS08900	COG3938	Belongs to the proline racemase family
FR741_RS08930	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FR741_RS08935	COG1451	nucleotide metabolic process
FR741_RS08945	COG0583	DNA-binding transcription factor activity
FR741_RS08965	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FR741_RS08970	COG4139	cobalamin transport
FR741_RS08975	COG2988	succinylglutamate desuccinylase activity
FR741_RS08995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FR741_RS09000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FR741_RS09005	COG0702	epimerase
FR741_RS09015	COG2925	Exonuclease
FR741_RS09020	COG1380	Effector of murein hydrolase LrgA
FR741_RS09025	COG1346	cytolysis
FR741_RS09030	COG0295	cytidine deaminase activity
FR741_RS09035	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FR741_RS09040	COG0500	methyltransferase
FR741_RS09050	COG0776	regulation of translation
FR741_RS09060	COG0072	phenylalanine-tRNA ligase activity
FR741_RS09060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR741_RS09065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FR741_RS09095	COG0393	Putative heavy-metal-binding
FR741_RS09105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FR741_RS09115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FR741_RS09130	COG2188	Transcriptional regulator
FR741_RS09135	COG1228	amidohydrolase
FR741_RS09140	COG0010	Belongs to the arginase family
FR741_RS09145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FR741_RS09150	COG2986	histidine ammonia-lyase
FR741_RS09165	COG0277	FAD linked oxidase domain protein
FR741_RS09165	COG0247	lactate metabolic process
FR741_RS09200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FR741_RS09215	COG1643	Atp-dependent helicase
FR741_RS09220	COG0281	malic enzyme
FR741_RS09225	COG2949	membrane
FR741_RS09230	COG0471	metal ion transport
FR741_RS09255	COG0492	ferredoxin-NADP+ reductase activity
FR741_RS09260	COG4988	ABC transporter
FR741_RS09265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FR741_RS09275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FR741_RS09285	COG4191	Histidine kinase
FR741_RS09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR741_RS09300	COG3070	regulator of competence-specific genes
FR741_RS09310	COG2431	L-lysine efflux transmembrane transporter activity
FR741_RS09320	COG0076	glutamate decarboxylase activity
FR741_RS09325	COG1737	Transcriptional regulator
FR741_RS09335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FR741_RS09340	COG2985	domain, Protein
FR741_RS09340	COG3273	potassium ion transport
FR741_RS09345	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FR741_RS09350	COG1960	acyl-CoA dehydrogenase activity
FR741_RS09360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FR741_RS09380	COG0534	Mate efflux family protein
FR741_RS09385	COG0702	epimerase
FR741_RS09390	COG3005	denitrification pathway
FR741_RS09420	COG2814	Major facilitator Superfamily
FR741_RS09425	COG1187	pseudouridine synthase activity
FR741_RS09430	COG1061	Type III restriction enzyme res subunit
FR741_RS09440	COG0745	RESPONSE REGULATOR receiver
FR741_RS09445	COG2205	protein histidine kinase activity
FR741_RS09450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FR741_RS09470	COG3313	Fe-S protein
FR741_RS09480	COG4134	Bacterial extracellular solute-binding protein
FR741_RS09485	COG4135	transport system, permease component
FR741_RS09490	COG4136	ATPase activity
FR741_RS09495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FR741_RS09505	COG3604	Transcriptional regulator
FR741_RS09510	COG1151	hydroxylamine reductase activity
FR741_RS09515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR741_RS09525	COG0564	pseudouridine synthase activity
FR741_RS09530	COG0733	neurotransmitter:sodium symporter activity
FR741_RS09540	COG0626	cystathionine gamma-synthase activity
FR741_RS09545	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FR741_RS09550	COG5380	lipid catabolic process
FR741_RS09555	COG2818	Glycosylase
FR741_RS09575	COG1983	PspC domain protein
FR741_RS09585	COG1842	Phage shock protein A
FR741_RS09590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FR741_RS09605	COG4171	peptide transport system, permease
FR741_RS09615	COG4172	Belongs to the ABC transporter superfamily
FR741_RS09625	COG1227	inorganic diphosphatase activity
FR741_RS09640	COG0243	molybdopterin cofactor binding
FR741_RS09645	COG3005	denitrification pathway
FR741_RS09650	COG4459	periplasmic nitrate reductase
FR741_RS09655	COG0390	transport system, permease component
FR741_RS09660	COG2116	formate transmembrane transporter activity
FR741_RS09685	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FR741_RS09690	COG1435	thymidine kinase activity
FR741_RS09695	COG0215	cysteine-tRNA ligase activity
FR741_RS09700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FR741_RS09705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR741_RS09710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FR741_RS09715	COG3012	SEC-C Motif Domain Protein
FR741_RS09720	COG0140	phosphoribosyl-ATP diphosphatase activity
FR741_RS09720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FR741_RS09735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FR741_RS09740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FR741_RS09740	COG0131	Imidazoleglycerol-phosphate dehydratase
FR741_RS09745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FR741_RS09750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FR741_RS09755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FR741_RS09765	COG1757	Na H antiporter
FR741_RS09775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR741_RS09785	COG0482	sulfurtransferase activity
FR741_RS09790	COG2915	High frequency lysogenization protein hflD homolog
FR741_RS09795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FR741_RS09805	COG2268	Band 7 protein
FR741_RS09815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FR741_RS09830	COG0300	oxidoreductase activity
FR741_RS09850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FR741_RS09855	COG1073	alpha beta
FR741_RS09855	COG2226	methyltransferase
FR741_RS09875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FR741_RS09890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FR741_RS09895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FR741_RS09900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FR741_RS09905	COG1674	ftsk spoiiie
FR741_RS09915	COG0686	Belongs to the AlaDH PNT family
FR741_RS09925	COG0583	DNA-binding transcription factor activity
FR741_RS09940	COG0840	transmembrane signaling receptor activity
FR741_RS09950	COG3568	Endonuclease Exonuclease Phosphatase
FR741_RS09975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR741_RS09980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS09985	COG0840	transmembrane signaling receptor activity
FR741_RS10000	COG5002	protein histidine kinase activity
FR741_RS10000	COG0784	Response regulator, receiver
FR741_RS10010	COG0754	glutathionylspermidine amidase activity
FR741_RS10020	COG3766	membrane
FR741_RS10030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FR741_RS10035	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FR741_RS10040	COG2885	chlorophyll binding
FR741_RS10045	COG0823	Involved in the tonB-independent uptake of proteins
FR741_RS10060	COG0811	peptide transport
FR741_RS10065	COG0824	Thioesterase
FR741_RS10075	COG4890	Cyd operon protein YbgT
FR741_RS10080	COG1294	oxidase, subunit
FR741_RS10085	COG1271	oxidase subunit
FR741_RS10090	COG2255	four-way junction helicase activity
FR741_RS10095	COG0632	four-way junction helicase activity
FR741_RS10100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FR741_RS10105	COG0217	transcriptional regulatory protein
FR741_RS10115	COG1801	Protein of unknown function DUF72
FR741_RS10125	COG0500	methyltransferase
FR741_RS10130	COG4067	protein conserved in archaea
FR741_RS10130	COG0189	ligase activity
FR741_RS10150	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FR741_RS10155	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FR741_RS10160	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FR741_RS10165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR741_RS10170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FR741_RS10175	COG0745	RESPONSE REGULATOR receiver
FR741_RS10180	COG3381	protein complex oligomerization
FR741_RS10185	COG1609	Transcriptional regulator
FR741_RS10190	COG3070	regulator of competence-specific genes
FR741_RS10210	COG0297	glycogen (starch) synthase activity
FR741_RS10215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FR741_RS10220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FR741_RS10240	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FR741_RS10245	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FR741_RS10250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FR741_RS10255	COG0542	response to heat
FR741_RS10260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FR741_RS10265	COG1278	Cold shock
FR741_RS10275	COG1187	pseudouridine synthase activity
FR741_RS10280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FR741_RS10285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR741_RS10290	COG1199	ATP-dependent helicase activity
FR741_RS10295	COG0730	response to heat
FR741_RS10300	COG3923	Primosomal replication protein n
FR741_RS10310	COG0708	Exodeoxyribonuclease III
FR741_RS10350	COG1882	Formate acetyltransferase
FR741_RS10360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FR741_RS10370	COG3013	Belongs to the UPF0304 family
FR741_RS10375	COG2766	serine protein kinase
FR741_RS10380	COG2718	Belongs to the UPF0229 family
FR741_RS10385	COG2719	SpoVR family
FR741_RS10405	COG1132	(ABC) transporter
FR741_RS10410	COG2333	competence protein COMEC
FR741_RS10410	COG0658	competence protein
FR741_RS10420	COG4591	ABC-type transport system involved in lipoprotein release permease component
FR741_RS10425	COG1136	(ABC) transporter
FR741_RS10430	COG4591	ABC-type transport system involved in lipoprotein release permease component
FR741_RS10440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FR741_RS10455	COG1252	NADH dehydrogenase
FR741_RS10460	COG3150	esterase
FR741_RS10485	COG0537	adenosine 5'-monophosphoramidase activity
FR741_RS10510	COG0516	GMP reductase activity
FR741_RS10510	COG0517	IMP dehydrogenase activity
FR741_RS10515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR741_RS10545	COG1946	Acyl-CoA thioesterase
FR741_RS10555	COG1522	sequence-specific DNA binding
FR741_RS10580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR741_RS10585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS10630	COG2814	Major facilitator Superfamily
FR741_RS10635	COG2855	membrane
FR741_RS10655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FR741_RS10660	COG0596	Alpha beta hydrolase
FR741_RS10665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FR741_RS10670	COG1169	isochorismate synthase
FR741_RS10675	COG0436	Aminotransferase
FR741_RS10680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FR741_RS10685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FR741_RS10700	COG1555	photosystem II stabilization
FR741_RS10705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR741_RS10710	COG0776	regulation of translation
FR741_RS10715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FR741_RS10720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FR741_RS10730	COG0544	peptidyl-prolyl cis-trans isomerase activity
FR741_RS10750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FR741_RS10755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FR741_RS10760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FR741_RS10765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FR741_RS10780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR741_RS10785	COG0569	domain protein
FR741_RS10790	COG0513	Belongs to the DEAD box helicase family
FR741_RS10795	COG1253	flavin adenine dinucleotide binding
FR741_RS10830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FR741_RS10835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FR741_RS10845	COG0318	PFAM AMP-dependent synthetase and ligase
FR741_RS10850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FR741_RS10855	COG1216	Glycosyl transferase, family 2
FR741_RS10860	COG2986	histidine ammonia-lyase
FR741_RS10885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FR741_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS10915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FR741_RS10920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FR741_RS10930	COG2951	lytic endotransglycosylase activity
FR741_RS10935	COG3100	YcgL domain-containing protein
FR741_RS10940	COG0850	regulation of cytokinetic process
FR741_RS10945	COG2894	cell division
FR741_RS10950	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FR741_RS10955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FR741_RS10960	COG0318	PFAM AMP-dependent synthetase and ligase
FR741_RS10965	COG2267	carboxylic ester hydrolase activity
FR741_RS10970	COG3065	identical protein binding
FR741_RS10980	COG1214	PFAM Peptidase M22, glycoprotease
FR741_RS10985	COG1199	ATP-dependent helicase activity
FR741_RS10990	COG0788	formyltetrahydrofolate deformylase activity
FR741_RS10995	COG3102	Protein conserved in bacteria
FR741_RS11000	COG0018	arginyl-trna synthetase
FR741_RS11020	COG1918	ferrous iron import across plasma membrane
FR741_RS11025	COG4977	sequence-specific DNA binding
FR741_RS11030	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FR741_RS11035	COG1121	(ABC) transporter
FR741_RS11040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FR741_RS11055	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR741_RS11060	COG0567	Dehydrogenase, E1 component
FR741_RS11065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FR741_RS11070	COG1053	succinate dehydrogenase
FR741_RS11075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FR741_RS11090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FR741_RS11100	COG0033	Phosphoglucomutase
FR741_RS11105	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FR741_RS11110	COG0596	Alpha beta hydrolase
FR741_RS11120	COG0716	FMN binding
FR741_RS11130	COG0735	belongs to the Fur family
FR741_RS11135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR741_RS11140	COG2190	(PTS) system
FR741_RS11140	COG1263	PTS System
FR741_RS11140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR741_RS11145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FR741_RS11150	COG1846	Transcriptional regulator
FR741_RS11150	COG1940	carbohydrate kinase activity
FR741_RS11155	COG4651	solute:proton antiporter activity
FR741_RS11155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FR741_RS11160	COG0367	asparagine synthase
FR741_RS11165	COG0250	Participates in transcription elongation, termination and antitermination
FR741_RS11170	COG3104	oligopeptide transport
FR741_RS11175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FR741_RS11185	COG0326	Molecular chaperone. Has ATPase activity
FR741_RS11190	COG3710	Transcriptional regulator
FR741_RS11210	COG0622	Phosphoesterase
FR741_RS11240	COG1090	epimerase
FR741_RS11245	COG0300	oxidoreductase activity
FR741_RS11250	COG3118	belongs to the thioredoxin family
FR741_RS11255	COG0330	HflC and HflK could
FR741_RS11275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FR741_RS11280	COG3115	cell septum assembly
FR741_RS11285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FR741_RS11290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FR741_RS11295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS11300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FR741_RS11305	COG2190	(PTS) system
FR741_RS11310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS11315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS11320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS11325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS11335	COG3951	Flagellar rod assembly protein muramidase FlgJ
FR741_RS11335	COG1705	Flagellar rod assembly protein muramidase FlgJ
FR741_RS11340	COG1706	bacterial-type flagellum-dependent cell motility
FR741_RS11345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FR741_RS11355	COG4787	bacterial-type flagellum-dependent cell motility
FR741_RS11360	COG1749	Flagellar hook protein flgE
FR741_RS11370	COG1558	bacterial-type flagellum-dependent cell motility
FR741_RS11375	COG1815	bacterial-type flagellum-dependent cell motility
FR741_RS11380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FR741_RS11385	COG0784	Response regulator, receiver
FR741_RS11385	COG0835	chemotaxis
FR741_RS11440	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FR741_RS11450	COG2608	mercury ion transmembrane transporter activity
FR741_RS11450	COG2217	Heavy metal translocating P-type atpase
FR741_RS11490	COG2840	Smr protein MutS2
FR741_RS11495	COG1187	pseudouridine synthase activity
FR741_RS11500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FR741_RS11505	COG0737	Belongs to the 5'-nucleotidase family
FR741_RS11510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FR741_RS11515	COG2912	Transglutaminase-like superfamily
FR741_RS11520	COG3094	Invasion gene expression up-regulator, SirB
FR741_RS11525	COG2890	protein-(glutamine-N5) methyltransferase activity
FR741_RS11535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FR741_RS11540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FR741_RS11550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FR741_RS11555	COG0193	aminoacyl-tRNA hydrolase activity
FR741_RS11560	COG0012	GTP binding
FR741_RS11665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR741_RS11670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FR741_RS11675	COG1702	phosphate starvation-inducible protein PhoH
FR741_RS11680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FR741_RS11685	COG4535	Mg2 and Co2 transporter CorC
FR741_RS11690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FR741_RS11695	COG2888	peptidyl-tyrosine sulfation
FR741_RS11700	COG0495	leucyl-tRNA aminoacylation
FR741_RS11705	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FR741_RS11710	COG1466	dna polymerase III delta subunit
FR741_RS11715	COG0799	negative regulation of ribosome biogenesis
FR741_RS11720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FR741_RS11725	COG0768	penicillin binding
FR741_RS11730	COG0772	Belongs to the SEDS family
FR741_RS11735	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FR741_RS11740	COG1686	Belongs to the peptidase S11 family
FR741_RS11750	COG0321	lipoyl(octanoyl) transferase activity
FR741_RS11755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FR741_RS11760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FR741_RS11765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FR741_RS11780	COG0366	Alpha amylase catalytic
FR741_RS11785	COG1263	PTS System
FR741_RS11785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR741_RS11795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FR741_RS11800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FR741_RS11805	COG2011	ABC-type metal ion transport system permease component
FR741_RS11810	COG1464	Belongs to the NlpA lipoprotein family
FR741_RS11815	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FR741_RS11825	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FR741_RS11825	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FR741_RS11840	COG1611	Belongs to the LOG family
FR741_RS11845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FR741_RS11855	COG2363	Small membrane protein
FR741_RS11865	COG0583	DNA-binding transcription factor activity
FR741_RS11870	COG0301	tRNA thio-modification
FR741_RS11870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR741_RS11880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FR741_RS11885	COG1722	exodeoxyribonuclease VII activity
FR741_RS11890	COG0142	geranyltranstransferase activity
FR741_RS11895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FR741_RS11900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FR741_RS11905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FR741_RS11915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FR741_RS11930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR741_RS11930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR741_RS11935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FR741_RS11940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FR741_RS11945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FR741_RS11960	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FR741_RS11965	COG2252	PERMEase
FR741_RS11970	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR741_RS11985	COG1629	transport
FR741_RS12000	COG0047	phosphoribosylformylglycinamidine synthase activity
FR741_RS12000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FR741_RS12005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FR741_RS12015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FR741_RS12035	COG4969	Belongs to the N-Me-Phe pilin family
FR741_RS12045	COG0484	heat shock protein binding
FR741_RS12055	COG1301	dicarboxylic acid transport
FR741_RS12060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FR741_RS12065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FR741_RS12075	COG0497	DNA recombination
FR741_RS12080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR741_RS12085	COG2914	Belongs to the UPF0125 (RnfH) family
FR741_RS12090	COG2867	negative regulation of translational initiation
FR741_RS12095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FR741_RS12105	COG0582	viral genome integration into host DNA
FR741_RS12115	COG2207	Transcriptional regulator
FR741_RS12140	COG0583	DNA-binding transcription factor activity
FR741_RS12145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR741_RS12145	COG3153	acetyltransferase
FR741_RS12165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FR741_RS12170	COG2873	o-acetylhomoserine
FR741_RS12190	COG1115	amino acid carrier protein
FR741_RS12195	COG1584	GPR1 FUN34 yaaH family protein
FR741_RS12205	COG1757	Na H antiporter
FR741_RS12265	COG0582	viral genome integration into host DNA
FR741_RS12270	COG0519	Catalyzes the synthesis of GMP from XMP
FR741_RS12270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FR741_RS12275	COG0517	IMP dehydrogenase activity
FR741_RS12275	COG0516	GMP reductase activity
FR741_RS12295	COG1160	GTP binding
FR741_RS12300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR741_RS12305	COG2976	Protein conserved in bacteria
FR741_RS12310	COG0124	histidyl-tRNA synthetase
FR741_RS12315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FR741_RS12330	COG0105	UTP biosynthetic process
FR741_RS12340	COG2975	iron-sulfur cluster assembly
FR741_RS12345	COG0633	Ferredoxin
FR741_RS12350	COG0443	Heat shock 70 kDa protein
FR741_RS12365	COG0822	iron-sulfur transferase activity
FR741_RS12370	COG1104	cysteine desulfurase activity
FR741_RS12380	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FR741_RS12385	COG0483	inositol monophosphate 1-phosphatase activity
FR741_RS12390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR741_RS12395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR741_RS12400	COG1862	Preprotein translocase
FR741_RS12410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FR741_RS12420	COG0517	IMP dehydrogenase activity
FR741_RS12430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FR741_RS12435	COG0583	DNA-binding transcription factor activity
FR741_RS12440	COG0450	alkyl hydroperoxide reductase
FR741_RS12445	COG3142	Participates in the control of copper homeostasis
FR741_RS12455	COG0704	Plays a role in the regulation of phosphate uptake
FR741_RS12460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FR741_RS12465	COG0581	inorganic phosphate transmembrane transporter activity
FR741_RS12470	COG0573	inorganic phosphate transmembrane transporter activity
FR741_RS12475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FR741_RS12480	COG0248	Ppx GppA phosphatase
FR741_RS12490	COG5002	protein histidine kinase activity
FR741_RS12495	COG0745	RESPONSE REGULATOR receiver
FR741_RS12500	COG2974	May be involved in recombination
FR741_RS12510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR741_RS12565	COG0542	response to heat
FR741_RS12575	COG0564	pseudouridine synthase activity
FR741_RS12580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR741_RS12585	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FR741_RS12590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FR741_RS12595	COG0077	Prephenate dehydratase
FR741_RS12595	COG1605	Chorismate mutase
FR741_RS12600	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FR741_RS12605	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FR741_RS12615	COG0488	(ABC) transporter
FR741_RS12625	COG0741	lytic transglycosylase activity
FR741_RS12625	COG0739	heme binding
FR741_RS12625	COG1196	nuclear chromosome segregation
FR741_RS12630	COG0287	Prephenate dehydrogenase
FR741_RS12630	COG1605	Chorismate mutase
FR741_RS12635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR741_RS12640	COG1472	Belongs to the glycosyl hydrolase 3 family
FR741_RS12645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FR741_RS12665	COG1966	Carbon starvation protein
FR741_RS12670	COG3275	phosphorelay sensor kinase activity
FR741_RS12675	COG3279	Response regulator of the LytR AlgR family
FR741_RS12685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FR741_RS12690	COG1047	Peptidyl-prolyl cis-trans
FR741_RS12695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FR741_RS12705	COG0196	riboflavin kinase activity
FR741_RS12710	COG0728	peptidoglycan biosynthetic process
FR741_RS12715	COG0268	Binds directly to 16S ribosomal RNA
FR741_RS12720	COG0640	Transcriptional regulator
FR741_RS12725	COG0583	DNA-binding transcription factor activity
FR741_RS12730	COG1283	sodium-dependent phosphate transmembrane transporter activity
FR741_RS12740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FR741_RS12750	COG0730	response to heat
FR741_RS12775	COG0667	Aldo Keto reductase
FR741_RS12785	COG2204	response regulator
FR741_RS12790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FR741_RS12800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FR741_RS12805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR741_RS12810	COG4974	Belongs to the 'phage' integrase family
FR741_RS12815	COG0716	FMN binding
FR741_RS12825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FR741_RS12830	COG0513	Belongs to the DEAD box helicase family
FR741_RS12835	COG3022	response to hydroperoxide
FR741_RS12840	COG1115	amino acid carrier protein
FR741_RS12855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FR741_RS12860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FR741_RS12865	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FR741_RS12875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FR741_RS12880	COG0083	homoserine kinase activity
FR741_RS12900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FR741_RS12910	COG0745	RESPONSE REGULATOR receiver
FR741_RS12920	COG5002	protein histidine kinase activity
FR741_RS12920	COG0784	Response regulator, receiver
FR741_RS12920	COG2198	Histidine kinase
FR741_RS12925	COG5001	Diguanylate cyclase
FR741_RS12925	COG2203	Gaf domain
FR741_RS12925	COG4251	negative regulation of phosphorylation
FR741_RS12925	COG3706	GGDEF domain
FR741_RS12930	COG1242	4 iron, 4 sulfur cluster binding
FR741_RS12935	COG0067	glutamate synthase
FR741_RS12935	COG0069	glutamate synthase activity
FR741_RS12935	COG0070	glutamate synthase
FR741_RS12945	COG0070	glutamate synthase
FR741_RS12945	COG0067	glutamate synthase
FR741_RS12945	COG0069	glutamate synthase activity
FR741_RS12950	COG0493	'glutamate synthase
FR741_RS12960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FR741_RS12975	COG2860	membrane
FR741_RS12980	COG0583	DNA-binding transcription factor activity
FR741_RS12985	COG0730	response to heat
FR741_RS13000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FR741_RS13005	COG0505	Belongs to the CarA family
FR741_RS13020	COG0494	nUDIX hydrolase
FR741_RS13025	COG0653	protein targeting
FR741_RS13035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FR741_RS13040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FR741_RS13045	COG0849	cell division
FR741_RS13050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FR741_RS13055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FR741_RS13065	COG0772	Belongs to the SEDS family
FR741_RS13070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FR741_RS13075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FR741_RS13080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FR741_RS13085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FR741_RS13090	COG0768	penicillin binding
FR741_RS13095	COG3116	cell division
FR741_RS13110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FR741_RS13125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FR741_RS13130	COG2823	Periplasmic or secreted lipoprotein
FR741_RS13135	COG2969	positive regulation of protein catabolic process
FR741_RS13140	COG0625	glutathione transferase activity
FR741_RS13145	COG2857	Cytochrome c1
FR741_RS13150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FR741_RS13155	COG0723	plastoquinol--plastocyanin reductase activity
FR741_RS13160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FR741_RS13165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FR741_RS13170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FR741_RS13175	COG3105	Protein conserved in bacteria
FR741_RS13185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FR741_RS13190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FR741_RS13200	COG3150	esterase
FR741_RS13210	COG3151	Protein conserved in bacteria
FR741_RS13215	COG0494	nUDIX hydrolase
FR741_RS13220	COG1538	Outer membrane efflux protein
FR741_RS13225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FR741_RS13225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FR741_RS13230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FR741_RS13245	COG3025	triphosphatase activity
FR741_RS13250	COG1392	Phosphate transport regulator
FR741_RS13255	COG0306	phosphate transporter
FR741_RS13260	COG4991	sh3 domain protein
FR741_RS13265	COG0405	Gamma-glutamyltransferase
FR741_RS13275	COG3409	Peptidoglycan-binding domain 1 protein
FR741_RS13275	COG3267	Type II secretory pathway component ExeA
FR741_RS13280	COG0617	tRNA 3'-terminal CCA addition
FR741_RS13285	COG1968	undecaprenyl-diphosphatase activity
FR741_RS13290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FR741_RS13295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FR741_RS13300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FR741_RS13305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR741_RS13310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FR741_RS13315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FR741_RS13320	COG1610	YqeY-like protein
FR741_RS13325	COG0358	DNA primase activity
FR741_RS13400	COG1484	DNA-dependent DNA replication
FR741_RS13440	COG0582	viral genome integration into host DNA
FR741_RS13545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS13545	COG2213	PTS system mannitol-specific
FR741_RS13550	COG0246	Mannitol dehydrogenase
FR741_RS13555	COG3722	fumarate hydratase activity
FR741_RS13570	COG1461	Dihydroxyacetone kinase
FR741_RS13575	COG2376	Dihydroxyacetone kinase
FR741_RS13585	COG5002	protein histidine kinase activity
FR741_RS13600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FR741_RS13605	COG1349	DNA-binding transcription factor activity
FR741_RS13610	COG0469	pyruvate kinase activity
FR741_RS13620	COG3706	GGDEF domain
FR741_RS13630	COG0028	Belongs to the TPP enzyme family
FR741_RS13635	COG1022	Amp-dependent synthetase and ligase
FR741_RS13640	COG0583	DNA-binding transcription factor activity
FR741_RS13660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FR741_RS13665	COG0473	3-isopropylmalate dehydrogenase activity
FR741_RS13685	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FR741_RS13690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FR741_RS13695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR741_RS13700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FR741_RS13705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FR741_RS13710	COG2967	ApaG domain
FR741_RS13730	COG2966	Psort location CytoplasmicMembrane, score
FR741_RS13735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FR741_RS13745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FR741_RS13750	COG0142	geranyltranstransferase activity
FR741_RS13770	COG2358	TRAP transporter, solute receptor (TAXI family
FR741_RS13785	COG1902	pentaerythritol trinitrate reductase activity
FR741_RS13790	COG0583	DNA-binding transcription factor activity
FR741_RS13795	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FR741_RS13800	COG1178	ABC-type Fe3 transport system permease component
FR741_RS13805	COG4143	(ABC) transporter
FR741_RS13810	COG0163	prenyltransferase activity
FR741_RS13815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FR741_RS13820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FR741_RS13825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FR741_RS13835	COG2105	PFAM AIG2 family protein
FR741_RS13840	COG2911	Protein conserved in bacteria
FR741_RS13845	COG0729	surface antigen
FR741_RS13850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR741_RS13860	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FR741_RS13875	COG4181	ATPase activity
FR741_RS13895	COG0529	Catalyzes the synthesis of activated sulfate
FR741_RS13900	COG0471	metal ion transport
FR741_RS13900	COG3273	potassium ion transport
FR741_RS13905	COG2895	sulfate adenylyltransferase (ATP) activity
FR741_RS13910	COG0175	sulfate reduction
FR741_RS13915	COG1648	precorrin-2 dehydrogenase activity
FR741_RS13915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FR741_RS13930	COG0513	Belongs to the DEAD box helicase family
FR741_RS13935	COG2153	protein acetylation
FR741_RS13945	COG0545	Peptidyl-prolyl cis-trans isomerase
FR741_RS13955	COG0203	ribosomal protein L17
FR741_RS13960	COG0202	RNA polymerase activity
FR741_RS13970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FR741_RS13975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FR741_RS13980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FR741_RS13985	COG0201	protein transport
FR741_RS13995	COG1841	ribosomal large subunit assembly
FR741_RS14010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FR741_RS14015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FR741_RS14020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FR741_RS14025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FR741_RS14030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FR741_RS14040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FR741_RS14045	COG0255	Belongs to the universal ribosomal protein uL29 family
FR741_RS14055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FR741_RS14060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FR741_RS14065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FR741_RS14070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FR741_RS14080	COG0088	Forms part of the polypeptide exit tunnel
FR741_RS14085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FR741_RS14095	COG0254	rRNA binding
FR741_RS14100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FR741_RS14105	COG1609	Transcriptional regulator
FR741_RS14115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FR741_RS14120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FR741_RS14125	COG1575	Belongs to the MenA family. Type 1 subfamily
FR741_RS14130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FR741_RS14140	COG1494	fructose-1,6-bisphosphatase
FR741_RS14170	COG0149	triose-phosphate isomerase activity
FR741_RS14190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FR741_RS14200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR741_RS14205	COG0438	transferase activity, transferring glycosyl groups
FR741_RS14240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FR741_RS14245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FR741_RS14250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FR741_RS14255	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FR741_RS14260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FR741_RS14290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FR741_RS14290	COG0517	IMP dehydrogenase activity
FR741_RS14325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR741_RS14335	COG1560	Kdo2-lipid A biosynthetic process
FR741_RS14340	COG0859	PFAM glycosyl transferase family 9
FR741_RS14345	COG1519	Transferase
FR741_RS14355	COG1083	cytidylyl-transferase
FR741_RS14360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FR741_RS14370	COG2089	acid synthase
FR741_RS14375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FR741_RS14380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FR741_RS14385	COG1086	Polysaccharide biosynthesis protein
FR741_RS14395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FR741_RS14415	COG3642	lipopolysaccharide core region biosynthetic process
FR741_RS14420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FR741_RS14425	COG0859	PFAM glycosyl transferase family 9
FR741_RS14430	COG0463	Glycosyl transferase, family 2
FR741_RS14475	COG2003	Belongs to the UPF0758 family
FR741_RS14485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FR741_RS14490	COG1309	transcriptional regulator
FR741_RS14495	COG1560	Kdo2-lipid A biosynthetic process
FR741_RS14500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FR741_RS14505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FR741_RS14510	COG1561	YicC-like family, N-terminal region
FR741_RS14545	COG4608	Belongs to the ABC transporter superfamily
FR741_RS14550	COG0444	Belongs to the ABC transporter superfamily
FR741_RS14555	COG0747	negative chemotaxis
FR741_RS14560	COG4239	(ABC) transporter, permease
FR741_RS14565	COG4174	ABC transporter (Permease)
FR741_RS14585	COG0811	peptide transport
FR741_RS14590	COG0848	biopolymer transport protein
FR741_RS14605	COG0194	GDP metabolic process
FR741_RS14610	COG1758	RNA polymerase activity
FR741_RS14615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR741_RS14620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR741_RS14625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FR741_RS14630	COG2233	PERMEase
FR741_RS14635	COG2205	protein histidine kinase activity
FR741_RS14640	COG0745	RESPONSE REGULATOR receiver
FR741_RS14650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR741_RS14660	COG2183	response to ionizing radiation
FR741_RS14670	COG0596	Alpha beta hydrolase
FR741_RS14675	COG1040	competence protein
FR741_RS14680	COG0316	Belongs to the HesB IscA family
FR741_RS14680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FR741_RS14685	COG0494	nUDIX hydrolase
FR741_RS14690	COG1218	3'(2'),5'-bisphosphate nucleotidase
FR741_RS14700	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FR741_RS14705	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FR741_RS14710	COG3156	type II secretion system protein K
FR741_RS14715	COG4795	General secretion pathway protein
FR741_RS14720	COG2165	general secretion pathway protein
FR741_RS14725	COG2165	general secretion pathway protein
FR741_RS14730	COG2165	general secretion pathway protein
FR741_RS14735	COG1459	type II secretion system
FR741_RS14740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR741_RS14750	COG3031	protein transport across the cell outer membrane
FR741_RS14755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FR741_RS14760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FR741_RS14765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FR741_RS14775	COG0456	acetyltransferase
FR741_RS14780	COG1490	D-aminoacyl-tRNA deacylase activity
FR741_RS14785	COG1295	ribonuclease BN
FR741_RS14805	COG0174	glutamine synthetase
FR741_RS14815	COG3852	Histidine kinase
FR741_RS14820	COG2204	response regulator
FR741_RS14830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FR741_RS14860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FR741_RS14865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FR741_RS14865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FR741_RS14870	COG0456	acetyltransferase
FR741_RS14880	COG0084	hydrolase, TatD family'
FR741_RS14885	COG0805	protein transport
FR741_RS14890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FR741_RS14900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FR741_RS14905	COG3165	ubiquinone biosynthetic process from chorismate
FR741_RS14910	COG2226	methyltransferase
FR741_RS14915	COG1322	Protein conserved in bacteria
FR741_RS14930	COG0628	permease
FR741_RS14960	COG1597	lipid kinase activity
FR741_RS14990	COG2081	HI0933 family
FR741_RS15000	COG1528	Iron-storage protein
FR741_RS15005	COG0589	response to stress
FR741_RS15020	COG0742	ribosomal rna small subunit methyltransferase
FR741_RS15025	COG5001	Diguanylate cyclase
FR741_RS15025	COG5002	protein histidine kinase activity
FR741_RS15030	COG1522	sequence-specific DNA binding
FR741_RS15040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FR741_RS15045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR741_RS15050	COG0583	DNA-binding transcription factor activity
FR741_RS15055	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FR741_RS15060	COG0800	Aldolase
FR741_RS15065	COG2610	gluconate transmembrane transporter activity
FR741_RS15070	COG3265	gluconokinase activity
FR741_RS15075	COG0129	dihydroxy-acid dehydratase activity
FR741_RS15090	COG0583	DNA-binding transcription factor activity
FR741_RS15095	COG1609	Transcriptional regulator
FR741_RS15135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR741_RS15145	COG4166	transmembrane transport
FR741_RS15200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS15205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR741_RS15210	COG2960	long-chain fatty acid transporting porin activity
FR741_RS15215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FR741_RS15220	COG0583	DNA-binding transcription factor activity
FR741_RS15260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR741_RS15265	COG1739	Uncharacterized protein family UPF0029
FR741_RS15275	COG0183	Belongs to the thiolase family
FR741_RS15280	COG0604	alcohol dehydrogenase
FR741_RS15295	COG0425	Belongs to the sulfur carrier protein TusA family
FR741_RS15305	COG2119	membrane
FR741_RS15320	COG0751	glycine-tRNA ligase activity
FR741_RS15325	COG0366	Alpha amylase catalytic
FR741_RS15330	COG3977	Valine--pyruvate aminotransferase
FR741_RS15335	COG0071	Belongs to the small heat shock protein (HSP20) family
FR741_RS15350	COG0187	DNA topoisomerase II activity
FR741_RS15360	COG0592	DNA-directed DNA polymerase activity
FR741_RS15370	COG4608	Belongs to the ABC transporter superfamily
FR741_RS15375	COG0444	Belongs to the ABC transporter superfamily
FR741_RS15385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR741_RS15385	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FR741_RS15410	COG0772	Belongs to the SEDS family
FR741_RS15420	COG1136	(ABC) transporter
FR741_RS15440	COG3275	phosphorelay sensor kinase activity
FR741_RS15445	COG3279	Response regulator of the LytR AlgR family
FR741_RS15455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FR741_RS15475	COG0786	glutamate:sodium symporter activity
FR741_RS15485	COG1131	(ABC) transporter
FR741_RS15490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR741_RS15495	COG0786	glutamate:sodium symporter activity
FR741_RS15505	COG0363	glucosamine-6-phosphate deaminase activity
FR741_RS15525	COG1741	Belongs to the pirin family
FR741_RS15530	COG2259	Doxx family
FR741_RS15540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FR741_RS15545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FR741_RS15555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FR741_RS15580	COG0596	Alpha beta hydrolase
FR741_RS15595	COG3123	guanosine phosphorylase activity
FR741_RS15610	COG0534	Mate efflux family protein
FR741_RS15615	COG0564	pseudouridine synthase activity
FR741_RS15630	COG0583	DNA-binding transcription factor activity
FR741_RS15635	COG0561	phosphatase activity
FR741_RS15645	COG2199	diguanylate cyclase activity
FR741_RS15660	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FR741_RS15665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FR741_RS15670	COG0583	DNA-binding transcription factor activity
FR741_RS15685	COG1414	Transcriptional regulator
FR741_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS15700	COG1917	Cupin 2, conserved barrel domain protein
FR741_RS15715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR741_RS15720	COG0800	Aldolase
FR741_RS15740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR741_RS15745	COG0823	Involved in the tonB-independent uptake of proteins
FR741_RS15750	COG2375	cellular response to nickel ion
FR741_RS15785	COG1357	PFAM Pentapeptide repeats (8 copies)
FR741_RS15790	COG3047	cAMP biosynthetic process
FR741_RS15820	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FR741_RS15820	COG3408	Glycogen debranching enzyme
FR741_RS15825	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FR741_RS15845	COG0583	DNA-binding transcription factor activity
FR741_RS15860	COG0546	phosphoglycolate phosphatase activity
FR741_RS15885	COG3835	regulator
FR741_RS15890	COG2610	gluconate transmembrane transporter activity
FR741_RS15895	COG1929	Belongs to the glycerate kinase type-1 family
FR741_RS15900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR741_RS15920	COG0456	acetyltransferase
FR741_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS15940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR741_RS15945	COG3005	denitrification pathway
FR741_RS15950	COG0243	molybdopterin cofactor binding
FR741_RS15960	COG0352	thiamine-phosphate diphosphorylase activity
FR741_RS15965	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FR741_RS15970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FR741_RS15975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR741_RS15980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR741_RS15985	COG1116	anion transmembrane transporter activity
FR741_RS15990	COG0351	phosphomethylpyrimidine kinase
FR741_RS15995	COG0312	modulator of DNA gyrase
FR741_RS16000	COG0312	modulator of DNA gyrase
FR741_RS16005	COG1901	pseudouridine methyltransferase
FR741_RS16065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FR741_RS16075	COG0584	glycerophosphoryl diester phosphodiesterase
FR741_RS16080	COG0039	L-malate dehydrogenase activity
FR741_RS16085	COG0745	RESPONSE REGULATOR receiver
FR741_RS16105	COG0811	peptide transport
FR741_RS16110	COG0811	peptide transport
FR741_RS16115	COG0848	biopolymer transport protein
FR741_RS16160	COG0803	Belongs to the bacterial solute-binding protein 9 family
FR741_RS16165	COG1121	(ABC) transporter
FR741_RS16170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FR741_RS16185	COG1770	oligopeptidase
FR741_RS16190	COG2814	Major facilitator Superfamily
FR741_RS16195	COG0010	Belongs to the arginase family
FR741_RS16200	COG1166	arginine decarboxylase activity
FR741_RS16210	COG0189	ligase activity
FR741_RS16210	COG4067	protein conserved in archaea
FR741_RS16215	COG0189	ligase activity
FR741_RS16220	COG0583	DNA-binding transcription factor activity
FR741_RS16255	COG4191	Histidine kinase
FR741_RS16260	COG2204	response regulator
FR741_RS16265	COG3706	GGDEF domain
FR741_RS16285	COG0579	oxidoreductase
FR741_RS16300	COG1294	oxidase, subunit
FR741_RS16305	COG1271	oxidase subunit
FR741_RS16315	COG3033	Beta-eliminating lyase
FR741_RS16330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FR741_RS16345	COG3706	GGDEF domain
FR741_RS16360	COG3706	GGDEF domain
FR741_RS16365	COG0415	Belongs to the DNA photolyase family
FR741_RS16370	COG3046	protein related to deoxyribodipyrimidine photolyase
FR741_RS16385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR741_RS16385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR741_RS16390	COG1765	OsmC-like protein
FR741_RS16395	COG0110	maltose O-acetyltransferase activity
FR741_RS16435	COG1011	Hydrolase
FR741_RS16450	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FR741_RS16460	COG2067	long-chain fatty acid transport protein
FR741_RS16465	COG3240	lipase activity
FR741_RS16495	COG1609	Transcriptional regulator
FR741_RS16500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR741_RS16515	COG1840	ABC-type Fe3 transport system, periplasmic component
FR741_RS16520	COG3842	ATPase activity
FR741_RS16545	COG2990	Protein conserved in bacteria
FR741_RS16555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR741_RS16560	COG2866	Carboxypeptidase
FR741_RS16570	COG0583	DNA-binding transcription factor activity
FR741_RS16590	COG3104	oligopeptide transport
FR741_RS16595	COG1760	l-serine dehydratase
FR741_RS16615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FR741_RS16620	COG0741	lytic transglycosylase activity
FR741_RS16640	COG1815	bacterial-type flagellum-dependent cell motility
FR741_RS16645	COG1558	bacterial-type flagellum-dependent cell motility
FR741_RS16650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FR741_RS16655	COG1749	Flagellar hook protein flgE
FR741_RS16660	COG4787	bacterial-type flagellum-dependent cell motility
FR741_RS16665	COG4786	Flagellar basal body rod
FR741_RS16670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FR741_RS16675	COG1706	bacterial-type flagellum-dependent cell motility
FR741_RS16685	COG1256	bacterial-type flagellum assembly
FR741_RS16685	COG4786	Flagellar basal body rod
FR741_RS16690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS16710	COG1304	FMN binding
FR741_RS16725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR741_RS16730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FR741_RS16735	COG0459	protein refolding
FR741_RS16765	COG1309	transcriptional regulator
FR741_RS16770	COG2207	Transcriptional regulator
FR741_RS16775	COG4303	Ethanolamine ammonia lyase large subunit
FR741_RS16780	COG4302	ethanolamine ammonia-lyase activity
FR741_RS16785	COG0531	amino acid
FR741_RS16790	COG2070	2-Nitropropane dioxygenase
FR741_RS16795	COG3537	Alpha-1,2-mannosidase
FR741_RS16800	COG3537	Alpha-1,2-mannosidase
FR741_RS16810	COG3537	Alpha-1,2-mannosidase
FR741_RS16815	COG3537	Alpha-1,2-mannosidase
FR741_RS16820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR741_RS16830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR741_RS16830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR741_RS16835	COG0346	lactoylglutathione lyase activity
FR741_RS16840	COG1349	DNA-binding transcription factor activity
FR741_RS16850	COG1335	isochorismatase
FR741_RS16860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FR741_RS16885	COG0583	DNA-binding transcription factor activity
FR741_RS16900	COG3713	MltA-interacting MipA family protein
FR741_RS16905	COG3015	lipoprotein NlpE involved in copper resistance
FR741_RS16910	COG4175	Glycine betaine
FR741_RS16910	COG3448	diguanylate cyclase activity
FR741_RS16915	COG4176	ABC-type proline glycine betaine transport system permease component
FR741_RS16920	COG1342	Belongs to the UPF0251 family
FR741_RS16950	COG4948	Mandelate Racemase Muconate Lactonizing
FR741_RS16960	COG0583	DNA-binding transcription factor activity
FR741_RS16995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR741_RS17020	COG3842	ATPase activity
FR741_RS17050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR741_RS17075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS17090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FR741_RS17095	COG2197	response regulator
FR741_RS17110	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FR741_RS17115	COG0252	asparaginase activity
FR741_RS17125	COG0583	DNA-binding transcription factor activity
FR741_RS17140	COG3122	Protein conserved in bacteria
FR741_RS17150	COG2423	ornithine cyclodeaminase activity
FR741_RS17155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FR741_RS17160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FR741_RS17165	COG1012	belongs to the aldehyde dehydrogenase family
FR741_RS17170	COG1522	sequence-specific DNA binding
FR741_RS17175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FR741_RS17180	COG3608	succinylglutamate desuccinylase aspartoacylase
FR741_RS17185	COG0006	proline dipeptidase activity
FR741_RS17190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR741_RS17195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FR741_RS17200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FR741_RS17210	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS17220	COG1063	alcohol dehydrogenase
FR741_RS17225	COG1902	pentaerythritol trinitrate reductase activity
FR741_RS17240	COG0583	DNA-binding transcription factor activity
FR741_RS17250	COG0513	Belongs to the DEAD box helicase family
FR741_RS17285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR741_RS17290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FR741_RS17290	COG2207	Transcriptional regulator
FR741_RS17310	COG3746	phosphate-selective porin O and P
FR741_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS17355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR741_RS17355	COG1263	PTS System
FR741_RS17360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR741_RS17365	COG1621	beta-fructofuranosidase activity
FR741_RS17375	COG0625	glutathione transferase activity
FR741_RS17380	COG1686	Belongs to the peptidase S11 family
FR741_RS17395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FR741_RS17410	COG1278	Cold shock
FR741_RS17415	COG1741	Belongs to the pirin family
FR741_RS17420	COG4667	esterase of the alpha-beta hydrolase superfamily
FR741_RS17440	COG2194	sulfuric ester hydrolase activity
FR741_RS17445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FR741_RS17455	COG2205	protein histidine kinase activity
FR741_RS17460	COG0745	RESPONSE REGULATOR receiver
FR741_RS17475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR741_RS17495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR741_RS17505	COG2814	Major facilitator Superfamily
FR741_RS17515	COG1418	mRNA catabolic process
FR741_RS17520	COG0402	S-adenosylhomocysteine deaminase activity
FR741_RS17525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FR741_RS17530	COG2239	Acts as a magnesium transporter
FR741_RS17535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FR741_RS17540	COG1566	PFAM secretion protein HlyD family protein
FR741_RS17565	COG0745	RESPONSE REGULATOR receiver
FR741_RS17570	COG2205	protein histidine kinase activity
FR741_RS17585	COG0531	amino acid
FR741_RS17595	COG0583	DNA-binding transcription factor activity
FR741_RS17615	COG0784	Response regulator, receiver
FR741_RS17615	COG2205	protein histidine kinase activity
FR741_RS17615	COG5002	protein histidine kinase activity
FR741_RS17620	COG0534	Mate efflux family protein
FR741_RS17635	COG3132	Protein of unknown function, DUF480
FR741_RS17640	COG2827	Endonuclease containing a URI domain
FR741_RS17645	COG1879	ABC-type sugar transport system periplasmic component
FR741_RS17650	COG2205	protein histidine kinase activity
FR741_RS17650	COG0784	Response regulator, receiver
FR741_RS17710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR741_RS17715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR741_RS17725	COG1280	lysine exporter protein (LysE YggA)
FR741_RS17735	COG0183	Belongs to the thiolase family
FR741_RS17745	COG3243	poly(R)-hydroxyalkanoic acid synthase
FR741_RS17755	COG3005	denitrification pathway
FR741_RS17765	COG0243	molybdopterin cofactor binding
FR741_RS17775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR741_RS17780	COG3850	Histidine kinase
FR741_RS17785	COG2197	response regulator
FR741_RS17800	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR741_RS17820	COG0840	transmembrane signaling receptor activity
FR741_RS17830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR741_RS17840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR741_RS17845	COG2814	Major facilitator Superfamily
FR741_RS17850	COG0840	transmembrane signaling receptor activity
FR741_RS17855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FR741_RS17860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FR741_RS17880	COG2897	thiosulfate sulfurtransferase activity
FR741_RS17900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FR741_RS17915	COG1914	H( )-stimulated, divalent metal cation uptake system
FR741_RS17925	COG0038	chloride channel
FR741_RS17940	COG4989	oxidoreductase activity
FR741_RS17955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FR741_RS17955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FR741_RS18005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR741_RS18020	COG1013	pyruvate-flavodoxin oxidoreductase activity
FR741_RS18025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FR741_RS18025	COG0674	pyruvate-flavodoxin oxidoreductase activity
FR741_RS18030	COG0583	DNA-binding transcription factor activity
FR741_RS18035	COG0739	heme binding
FR741_RS18075	COG3501	Rhs element vgr protein
FR741_RS18100	COG0515	serine threonine protein kinase
FR741_RS18135	COG1522	sequence-specific DNA binding
FR741_RS18180	COG3179	chitinase
FR741_RS18205	COG2814	Major facilitator Superfamily
FR741_RS18215	COG0583	DNA-binding transcription factor activity
FR741_RS18220	COG4221	oxidoreductase activity
FR741_RS18225	COG0589	response to stress
FR741_RS18235	COG2111	Na H antiporter
FR741_RS18235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FR741_RS18255	COG2212	antiporter activity
FR741_RS18260	COG1320	monovalent cation:proton antiporter activity
FR741_RS18265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR741_RS18325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR741_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS18340	COG3527	Alpha-acetolactate decarboxylase
FR741_RS18350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR741_RS18365	COG1294	oxidase, subunit
FR741_RS18370	COG1271	oxidase subunit
FR741_RS18375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR741_RS18380	COG0110	maltose O-acetyltransferase activity
FR741_RS18395	COG3437	response regulator, receiver
FR741_RS18395	COG2205	protein histidine kinase activity
FR741_RS18395	COG4999	Histidine kinase
FR741_RS18395	COG3850	Histidine kinase
FR741_RS18405	COG4770	biotin carboxylase activity
FR741_RS18415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR741_RS18420	COG1960	acyl-CoA dehydrogenase activity
FR741_RS18430	COG0183	Belongs to the thiolase family
FR741_RS18440	COG1960	acyl-CoA dehydrogenase activity
FR741_RS18445	COG1024	Enoyl-CoA hydratase
FR741_RS18460	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS18470	COG1309	transcriptional regulator
FR741_RS18475	COG1012	belongs to the aldehyde dehydrogenase family
FR741_RS18490	COG4176	ABC-type proline glycine betaine transport system permease component
FR741_RS18495	COG4175	Glycine betaine
FR741_RS18495	COG0517	IMP dehydrogenase activity
FR741_RS18510	COG0330	HflC and HflK could
FR741_RS18520	COG3300	MHYT domain
FR741_RS18520	COG5001	Diguanylate cyclase
FR741_RS18530	COG0784	Response regulator, receiver
FR741_RS18530	COG2205	protein histidine kinase activity
FR741_RS18540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FR741_RS18585	COG5001	Diguanylate cyclase
FR741_RS18590	COG1869	D-ribose catabolic process
FR741_RS18595	COG1129	ABC transporter
FR741_RS18600	COG1172	Belongs to the binding-protein-dependent transport system permease family
FR741_RS18605	COG1879	ABC-type sugar transport system periplasmic component
FR741_RS18610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR741_RS18615	COG1609	Transcriptional regulator
FR741_RS18625	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FR741_RS18635	COG4607	ABC-type enterochelin transport system periplasmic component
FR741_RS18640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR741_RS18645	COG4605	iron ion homeostasis
FR741_RS18650	COG4604	ABC transporter, ATP-binding protein
FR741_RS18655	COG0789	Transcriptional regulator
FR741_RS18660	COG2207	Transcriptional regulator
FR741_RS18665	COG4771	TonB-dependent receptor
FR741_RS18665	COG1629	transport
FR741_RS18695	COG1289	transmembrane transporter activity
FR741_RS18700	COG0210	DNA helicase
FR741_RS18705	COG1803	Methylglyoxal synthase
FR741_RS18710	COG1879	ABC-type sugar transport system periplasmic component
FR741_RS18715	COG2198	Histidine kinase
FR741_RS18715	COG2205	protein histidine kinase activity
FR741_RS18715	COG0784	Response regulator, receiver
FR741_RS18735	COG3119	arylsulfatase activity
FR741_RS18745	COG3119	arylsulfatase activity
FR741_RS18750	COG0641	radical SAM
FR741_RS18755	COG0714	Associated with various cellular activities
FR741_RS18785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR741_RS18785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR741_RS18790	COG0583	DNA-binding transcription factor activity
FR741_RS18795	COG1597	lipid kinase activity
FR741_RS18800	COG3111	PFAM Bacterial OB fold (BOF) protein
FR741_RS18815	COG2223	nitrite transmembrane transporter activity
FR741_RS18825	COG0501	Belongs to the peptidase M48B family
FR741_RS18830	COG1704	LemA family
FR741_RS18835	COG3069	C4-dicarboxylate transmembrane transporter activity
FR741_RS18845	COG0456	acetyltransferase
FR741_RS18845	COG1214	PFAM Peptidase M22, glycoprotease
FR741_RS18865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FR741_RS18880	COG3706	GGDEF domain
FR741_RS18890	COG2197	response regulator
FR741_RS18895	COG0835	chemotaxis
FR741_RS18895	COG0784	Response regulator, receiver
FR741_RS18910	COG2962	Rard protein
FR741_RS18970	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FR741_RS18975	COG5642	Protein of unknown function (DUF2384)
FR741_RS18985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FR741_RS18985	COG2755	lipolytic protein G-D-S-L family
FR741_RS18995	COG1902	pentaerythritol trinitrate reductase activity
FR741_RS19000	COG0346	lactoylglutathione lyase activity
FR741_RS19020	COG2239	Acts as a magnesium transporter
FR741_RS19050	COG0242	peptide deformylase activity
FR741_RS19090	COG2176	DNA-directed DNA polymerase activity
FR741_RS19115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FR741_RS19120	COG0346	lactoylglutathione lyase activity
FR741_RS19125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FR741_RS19125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FR741_RS19130	COG0509	glycine decarboxylation via glycine cleavage system
FR741_RS19135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FR741_RS19145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FR741_RS19155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS19175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR741_RS19175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FR741_RS19175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR741_RS19180	COG1105	Belongs to the carbohydrate kinase PfkB family
FR741_RS19185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS19185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS19190	COG1609	Transcriptional regulator
FR741_RS19205	COG2203	Gaf domain
FR741_RS19205	COG2199	diguanylate cyclase activity
FR741_RS19205	COG2200	EAL domain
FR741_RS19210	COG0765	amino acid transport
FR741_RS19215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR741_RS19220	COG0765	amino acid transport
FR741_RS19225	COG1126	abc transporter atp-binding protein
FR741_RS19235	COG1979	alcohol dehydrogenase
FR741_RS19240	COG2207	Transcriptional regulator
FR741_RS19250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FR741_RS19255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FR741_RS19260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR741_RS19275	COG0546	phosphoglycolate phosphatase activity
FR741_RS19280	COG0840	transmembrane signaling receptor activity
FR741_RS19290	COG0513	Belongs to the DEAD box helicase family
FR741_RS19295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FR741_RS19310	COG3038	cytochrome b561
FR741_RS19315	COG2353	YceI-like domain
FR741_RS19320	COG2116	formate transmembrane transporter activity
FR741_RS19325	COG0583	DNA-binding transcription factor activity
FR741_RS19335	COG3593	DNA synthesis involved in DNA repair
FR741_RS19340	COG0737	Belongs to the 5'-nucleotidase family
FR741_RS19365	COG2267	carboxylic ester hydrolase activity
FR741_RS19370	COG2067	long-chain fatty acid transport protein
FR741_RS19385	COG2050	protein possibly involved in aromatic compounds catabolism
FR741_RS19395	COG4533	DNA binding
FR741_RS19430	COG1716	ATPase activity
FR741_RS19430	COG5001	Diguanylate cyclase
FR741_RS19435	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FR741_RS19445	COG4181	ATPase activity
FR741_RS19450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FR741_RS19460	COG1984	allophanate hydrolase subunit 2
FR741_RS19465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FR741_RS19470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FR741_RS19475	COG3447	MASE1 domain protein
FR741_RS19475	COG5002	protein histidine kinase activity
FR741_RS19475	COG5001	Diguanylate cyclase
FR741_RS19480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FR741_RS19485	COG1629	transport
FR741_RS19485	COG4771	TonB-dependent receptor
FR741_RS19490	COG0583	DNA-binding transcription factor activity
FR741_RS19495	COG0045	succinate-CoA ligase (ADP-forming) activity
FR741_RS19495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR741_RS19495	COG1042	CoA-binding domain protein
FR741_RS19505	COG1181	Belongs to the D-alanine--D-alanine ligase family
FR741_RS19515	COG0023	Translation Initiation Factor
FR741_RS19605	COG0583	DNA-binding transcription factor activity
FR741_RS19615	COG0589	response to stress
FR741_RS19620	COG3140	Belongs to the UPF0181 family
FR741_RS19645	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FR741_RS19650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FR741_RS19675	COG2203	Gaf domain
FR741_RS19675	COG3706	GGDEF domain
FR741_RS19675	COG4251	negative regulation of phosphorylation
FR741_RS19675	COG5001	Diguanylate cyclase
FR741_RS19685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FR741_RS19690	COG4149	molybdate abc transporter
FR741_RS19695	COG0725	ABC transporter, periplasmic molybdate-binding protein
FR741_RS19715	COG0189	ligase activity
FR741_RS19715	COG4067	protein conserved in archaea
FR741_RS19725	COG2207	Transcriptional regulator
FR741_RS19730	COG0534	Mate efflux family protein
FR741_RS19735	COG0602	queuosine metabolic process
FR741_RS19740	COG1328	CTP reductase activity
FR741_RS19755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR741_RS19785	COG1794	racemase activity, acting on amino acids and derivatives
FR741_RS19790	COG0384	phenazine biosynthesis protein PhzF
FR741_RS19800	COG0243	molybdopterin cofactor binding
FR741_RS19805	COG0583	DNA-binding transcription factor activity
FR741_RS19810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FR741_RS19820	COG2197	response regulator
FR741_RS19825	COG3851	Histidine kinase
FR741_RS19830	COG2271	Major facilitator Superfamily
FR741_RS19855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FR741_RS19860	COG3118	belongs to the thioredoxin family
FR741_RS19895	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FR741_RS19915	COG2116	formate transmembrane transporter activity
FR741_RS19925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR741_RS19930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR741_RS19935	COG5001	Diguanylate cyclase
FR741_RS20005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FR741_RS20040	COG0277	FAD linked oxidase domain protein
FR741_RS20045	COG0583	DNA-binding transcription factor activity
FR741_RS20060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FR741_RS20075	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FR741_RS20085	COG1288	antiporter activity
FR741_RS20095	COG3040	lipid binding
FR741_RS20105	COG0419	ATPase involved in DNA repair
FR741_RS20110	COG0420	3'-5' exonuclease activity
FR741_RS20125	COG3501	Rhs element vgr protein
FR741_RS20180	COG0631	protein serine/threonine phosphatase activity
FR741_RS20215	COG2815	serine threonine protein kinase
FR741_RS20215	COG0515	serine threonine protein kinase
FR741_RS20265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR741_RS20265	COG2146	nitrite reductase [NAD(P)H] activity
FR741_RS20270	COG1116	anion transmembrane transporter activity
FR741_RS20275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR741_RS20280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR741_RS20280	COG1116	anion transmembrane transporter activity
FR741_RS20305	COG0243	molybdopterin cofactor binding
FR741_RS20315	COG0814	amino acid
FR741_RS20320	COG3706	GGDEF domain
FR741_RS20370	COG2847	Copper chaperone PCu(A)C
FR741_RS20375	COG0443	Heat shock 70 kDa protein
FR741_RS20440	COG4160	amino acid transport
FR741_RS20445	COG4215	(ABC) transporter
FR741_RS20450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR741_RS20455	COG1126	abc transporter atp-binding protein
FR741_RS20485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR741_RS20495	COG1012	belongs to the aldehyde dehydrogenase family
FR741_RS20515	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR741_RS20515	COG1902	pentaerythritol trinitrate reductase activity
FR741_RS20520	COG0109	protoheme IX farnesyltransferase activity
FR741_RS20525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FR741_RS20530	COG1845	cytochrome c oxidase, subunit III
FR741_RS20535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FR741_RS20540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FR741_RS20545	COG1028	Short-chain dehydrogenase reductase Sdr
FR741_RS20555	COG1024	Enoyl-CoA hydratase
FR741_RS20560	COG1024	Enoyl-CoA hydratase
FR741_RS20575	COG0183	Belongs to the thiolase family
FR741_RS20585	COG1960	acyl-CoA dehydrogenase activity
FR741_RS20590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR741_RS20595	COG1024	Enoyl-CoA hydratase
FR741_RS20605	COG5413	integral membrane protein
FR741_RS20670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FR741_RS20680	COG0513	Belongs to the DEAD box helicase family
FR741_RS20685	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FR741_RS20715	COG0840	transmembrane signaling receptor activity
FR741_RS20720	COG1119	ATPase activity
FR741_RS20725	COG2200	EAL domain
FR741_RS20745	COG0513	Belongs to the DEAD box helicase family
FR741_RS20750	COG0523	cobalamin synthesis protein
FR741_RS20760	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FR741_RS20770	COG1278	Cold shock
FR741_RS20775	COG0557	exoribonuclease II activity
FR741_RS20780	COG0133	tryptophan synthase activity
FR741_RS20790	COG4628	conserved protein (DUF2132)
FR741_RS20795	COG0513	Belongs to the DEAD box helicase family
FR741_RS20800	COG2814	Major facilitator Superfamily
FR741_RS20815	COG0730	response to heat
FR741_RS20860	COG1404	Belongs to the peptidase S8 family
FR741_RS20875	COG3530	Putative quorum-sensing-regulated virulence factor
FR741_RS20900	COG3186	Phenylalanine-4-hydroxylase
FR741_RS20905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR741_RS20910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR741_RS20935	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FR741_RS20940	COG1454	alcohol dehydrogenase
FR741_RS20945	COG2133	pyrroloquinoline quinone binding
FR741_RS20955	COG0783	Belongs to the Dps family
FR741_RS20960	COG0840	transmembrane signaling receptor activity
FR741_RS20970	COG1136	(ABC) transporter
FR741_RS20970	COG0577	efflux transmembrane transporter activity
FR741_RS20990	COG2199	diguanylate cyclase activity
FR741_RS20995	COG3036	rescue of stalled ribosome
FR741_RS21000	COG1278	Cold shock
FR741_RS21020	COG2885	chlorophyll binding
FR741_RS21030	COG0545	Peptidyl-prolyl cis-trans isomerase
FR741_RS21035	COG0109	protoheme IX farnesyltransferase activity
FR741_RS21040	COG1612	heme a metabolic process
FR741_RS21060	COG1845	cytochrome c oxidase, subunit III
FR741_RS21065	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FR741_RS21070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FR741_RS21075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FR741_RS21080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR741_RS21090	COG1280	lysine exporter protein (LysE YggA)
FR741_RS21095	COG2207	Transcriptional regulator
FR741_RS21110	COG0179	Fumarylacetoacetate (FAA) hydrolase
FR741_RS21130	COG0697	spore germination
FR741_RS21145	COG2814	Major facilitator Superfamily
FR741_RS21150	COG0583	DNA-binding transcription factor activity
FR741_RS21155	COG5001	Diguanylate cyclase
FR741_RS21160	COG0739	heme binding
FR741_RS21185	COG0840	transmembrane signaling receptor activity
FR741_RS21195	COG0814	amino acid
FR741_RS21210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FR741_RS21215	COG1072	(Pantothenic acid kinase))
FR741_RS21225	COG1063	alcohol dehydrogenase
FR741_RS21230	COG2213	PTS system mannitol-specific
FR741_RS21235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS21250	COG0798	PFAM Bile acid sodium symporter
FR741_RS21260	COG1881	PFAM PEBP family protein
FR741_RS21270	COG2706	6-phosphogluconolactonase activity
FR741_RS21280	COG1131	(ABC) transporter
FR741_RS21285	COG0842	Transport permease protein
FR741_RS21300	COG3383	formate dehydrogenase (NAD+) activity
FR741_RS21320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR741_RS21350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR741_RS21370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR741_RS21380	COG1505	serine-type exopeptidase activity
FR741_RS21385	COG0488	(ABC) transporter
FR741_RS21390	COG0589	response to stress
FR741_RS21395	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR741_RS21415	COG0366	Alpha amylase catalytic
FR741_RS21420	COG0789	Transcriptional regulator
FR741_RS21435	COG4934	collagen metabolic process
FR741_RS21445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FR741_RS21450	COG0583	DNA-binding transcription factor activity
FR741_RS21485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR741_RS21490	COG0835	chemotaxis
FR741_RS21490	COG0784	Response regulator, receiver
FR741_RS21500	COG0748	coenzyme F420 binding
FR741_RS21505	COG3721	Heme iron utilization protein
FR741_RS21515	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FR741_RS21520	COG0811	peptide transport
FR741_RS21525	COG0848	biopolymer transport protein
FR741_RS21535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR741_RS21540	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FR741_RS21580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FR741_RS21585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FR741_RS21590	COG0633	Ferredoxin
FR741_RS21590	COG0633	Ferredoxin
FR741_RS21590	COG3217	Mosc domain protein beta barrel domain protein
FR741_RS21590	COG3217	Mosc domain protein beta barrel domain protein
FR741_RS21595	COG0401	homolog of Blt101
FR741_RS21600	COG0418	dihydroorotase activity
FR741_RS21605	COG2354	Protein conserved in bacteria
FR741_RS21635	COG3833	ABC-type maltose transport systems, permease component
FR741_RS21640	COG1175	transmembrane transport
FR741_RS21650	COG3842	ATPase activity
FR741_RS21655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR741_RS21670	COG3206	protein involved in exopolysaccharide biosynthesis
FR741_RS21670	COG0489	protein tyrosine kinase activity
FR741_RS21715	COG1309	transcriptional regulator
FR741_RS21720	COG2130	NADP-dependent
FR741_RS21730	COG0753	catalase activity
FR741_RS21735	COG2084	Dehydrogenase
FR741_RS21740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR741_RS21745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR741_RS21755	COG2207	Transcriptional regulator
FR741_RS21760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR741_RS21760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR741_RS21760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR741_RS21790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR741_RS21795	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FR741_RS21800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FR741_RS21810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR741_RS21815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR741_RS21820	COG1012	belongs to the aldehyde dehydrogenase family
FR741_RS21835	COG0583	DNA-binding transcription factor activity
FR741_RS21840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR741_RS21845	COG0569	domain protein
FR741_RS21855	COG2205	protein histidine kinase activity
FR741_RS21860	COG1132	(ABC) transporter
FR741_RS21865	COG4774	siderophore transport
FR741_RS21870	COG1120	ATPase activity
FR741_RS21875	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FR741_RS21910	COG2197	response regulator
FR741_RS21920	COG0840	transmembrane signaling receptor activity
FR741_RS21925	COG0714	Associated with various cellular activities
FR741_RS21940	COG2304	oxidoreductase activity
FR741_RS21945	COG2304	oxidoreductase activity
FR741_RS21960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FR741_RS21965	COG0581	inorganic phosphate transmembrane transporter activity
FR741_RS21970	COG0573	inorganic phosphate transmembrane transporter activity
FR741_RS22000	COG4771	TonB-dependent receptor
FR741_RS22005	COG1770	oligopeptidase
FR741_RS22010	COG0513	Belongs to the DEAD box helicase family
FR741_RS22020	COG0110	maltose O-acetyltransferase activity
FR741_RS22095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FR741_RS22145	COG4695	Portal protein
FR741_RS22230	COG1376	ErfK ybiS ycfS ynhG family protein
FR741_RS22230	COG1388	LysM domain
FR741_RS22235	COG0415	Belongs to the DNA photolyase family
FR741_RS22240	COG0789	Transcriptional regulator
FR741_RS22245	COG3272	Protein of unknown function (DUF1722)
FR741_RS22250	COG0813	purine-nucleoside phosphorylase activity
FR741_RS22265	COG3706	GGDEF domain
FR741_RS22275	COG1566	PFAM secretion protein HlyD family protein
FR741_RS22280	COG4720	Psort location CytoplasmicMembrane, score
FR741_RS22285	COG1122	ATPase activity
FR741_RS22305	COG0348	domain, Protein
FR741_RS22310	COG0437	4 iron, 4 sulfur cluster binding
FR741_RS22315	COG1247	-acetyltransferase
FR741_RS22335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR741_RS22340	COG0840	transmembrane signaling receptor activity
FR741_RS22345	COG1067	ATP-dependent peptidase activity
FR741_RS22355	COG4172	Belongs to the ABC transporter superfamily
FR741_RS22360	COG1505	serine-type exopeptidase activity
FR741_RS22365	COG0583	DNA-binding transcription factor activity
FR741_RS22370	COG1620	l-lactate permease
FR741_RS22375	COG1304	FMN binding
FR741_RS22385	COG0668	transmembrane transport
FR741_RS22420	COG1063	alcohol dehydrogenase
FR741_RS22425	COG0156	8-amino-7-oxononanoate synthase activity
FR741_RS22430	COG5001	Diguanylate cyclase
FR741_RS22430	COG3300	MHYT domain
FR741_RS22435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR741_RS22455	COG0745	RESPONSE REGULATOR receiver
FR741_RS22480	COG0346	lactoylglutathione lyase activity
FR741_RS22535	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FR741_RS22575	COG1987	bacterial-type flagellum assembly
FR741_RS22585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FR741_RS22600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR741_RS22610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FR741_RS22615	COG1516	flagellar protein fliS
FR741_RS22630	COG1580	Controls the rotational direction of flagella during chemotaxis
FR741_RS22635	COG1191	sigma factor activity
FR741_RS22640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FR741_RS22645	COG1360	Flagellar Motor Protein
FR741_RS22695	COG1882	Formate acetyltransferase
FR741_RS22700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FR741_RS22705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FR741_RS22715	COG0454	-acetyltransferase
FR741_RS22725	COG2814	Major facilitator Superfamily
FR741_RS22755	COG1566	PFAM secretion protein HlyD family protein
FR741_RS22765	COG0628	permease
FR741_RS22770	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FR741_RS22785	COG4628	conserved protein (DUF2132)
FR741_RS22790	COG0583	DNA-binding transcription factor activity
FR741_RS22815	COG1686	Belongs to the peptidase S11 family
FR741_RS22835	COG0415	Belongs to the DNA photolyase family
FR741_RS22840	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FR741_RS22845	COG3397	chitin binding
FR741_RS22850	COG4667	esterase of the alpha-beta hydrolase superfamily
FR741_RS22855	COG2095	MarC family integral membrane protein
FR741_RS22870	COG1596	polysaccharide export
FR741_RS22890	COG1301	dicarboxylic acid transport
FR741_RS22910	COG3339	Conserved Protein
FR741_RS22915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FR741_RS22920	COG0700	Nucleoside recognition
FR741_RS22925	COG3366	ferrous iron transmembrane transporter activity
FR741_RS22940	COG0366	Alpha amylase catalytic
FR741_RS22945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FR741_RS22950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FR741_RS22955	COG1640	4-alpha-glucanotransferase
FR741_RS22960	COG0058	SHG alpha-glucan phosphorylase activity
FR741_RS22965	COG2909	trisaccharide binding
FR741_RS22980	COG1999	signal sequence binding
FR741_RS22985	COG1263	PTS System
FR741_RS22985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR741_RS22990	COG1162	GTPase activity
FR741_RS22995	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FR741_RS23000	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FR741_RS23010	COG0531	amino acid
FR741_RS23015	COG1982	Orn Lys Arg decarboxylase major
FR741_RS23035	COG2356	endonuclease I
FR741_RS23055	COG4580	involved in the transport of maltose and maltodextrins
FR741_RS23095	COG0739	heme binding
FR741_RS23105	COG0612	Peptidase, M16
FR741_RS23110	COG0840	transmembrane signaling receptor activity
FR741_RS23115	COG1120	ATPase activity
FR741_RS23120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR741_RS23125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR741_RS23130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FR741_RS23135	COG4772	TonB-dependent receptor
FR741_RS23160	COG4264	IucA IucC family
FR741_RS23165	COG0019	diaminopimelate decarboxylase activity
FR741_RS23170	COG1653	transport
FR741_RS23180	COG0745	RESPONSE REGULATOR receiver
FR741_RS23200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR741_RS23210	COG0463	Glycosyl transferase, family 2
FR741_RS23225	COG1136	(ABC) transporter
FR741_RS23245	COG1764	response to oxidative stress
FR741_RS23250	COG1846	Transcriptional regulator
FR741_RS23260	COG3634	alkyl hydroperoxide reductase activity
FR741_RS23285	COG1595	DNA-templated transcription, initiation
FR741_RS23305	COG2258	MOSC domain
FR741_RS23330	COG2207	Transcriptional regulator
FR741_RS23340	COG1132	(ABC) transporter
FR741_RS23375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR741_RS23400	COG0259	pyridoxamine-phosphate oxidase activity
FR741_RS23450	COG4166	transmembrane transport
FR741_RS23465	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FR741_RS23470	COG1263	PTS System
FR741_RS23470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR741_RS23475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR741_RS23480	COG3340	Belongs to the peptidase S51 family
FR741_RS23500	COG1444	tRNA N-acetyltransferase activity