locus-tag	class	description
AL537_RS00015	COG1677	Flagellar hook-basal body complex protein FliE
AL537_RS00035	COG1516	flagellar protein fliS
AL537_RS00045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL537_RS00050	COG1334	flagellar protein FlaG
AL537_RS00055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS00060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS00070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS00075	COG2837	iron assimilation
AL537_RS00100	COG1393	Belongs to the ArsC family
AL537_RS00105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL537_RS00120	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL537_RS00125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL537_RS00135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL537_RS00150	COG4783	chaperone-mediated protein folding
AL537_RS00155	COG1393	Belongs to the ArsC family
AL537_RS00175	COG2233	PERMEase
AL537_RS00180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL537_RS00185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL537_RS00190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL537_RS00195	COG0121	glutamine amidotransferase
AL537_RS00200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL537_RS00205	COG1960	acyl-CoA dehydrogenase activity
AL537_RS00240	COG0328	RNA-DNA hybrid ribonuclease activity
AL537_RS00245	COG2226	methyltransferase
AL537_RS00250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL537_RS00255	COG0741	lytic transglycosylase activity
AL537_RS00255	COG1388	LysM domain
AL537_RS00265	COG3021	interspecies interaction between organisms
AL537_RS00270	COG0347	Belongs to the P(II) protein family
AL537_RS00285	COG0825	malonyl-CoA metabolic process
AL537_RS00290	COG0587	DNA-directed DNA polymerase activity
AL537_RS00300	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_RS00305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_RS00315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_RS00320	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL537_RS00330	COG0750	zinc metalloprotease
AL537_RS00335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL537_RS00340	COG0575	Belongs to the CDS family
AL537_RS00345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL537_RS00350	COG0233	cytoplasmic translational termination
AL537_RS00355	COG0528	UMP kinase activity
AL537_RS00360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL537_RS00365	COG0052	Belongs to the universal ribosomal protein uS2 family
AL537_RS00370	COG0024	Methionine aminopeptidase
AL537_RS00375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL537_RS00385	COG0564	pseudouridine synthase activity
AL537_RS00420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL537_RS00425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL537_RS00450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL537_RS00460	COG0254	rRNA binding
AL537_RS00465	COG1720	tRNA m6t6A37 methyltransferase activity
AL537_RS00470	COG0442	prolyl-tRNA aminoacylation
AL537_RS00490	COG0733	neurotransmitter:sodium symporter activity
AL537_RS00505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_RS00510	COG0514	ATP-dependent DNA helicase (RecQ)
AL537_RS00515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL537_RS00530	COG1477	protein flavinylation
AL537_RS00535	COG2871	sodium ion transport
AL537_RS00540	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_RS00545	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_RS00550	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_RS00555	COG1805	sodium ion transport
AL537_RS00560	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL537_RS00570	COG0271	Belongs to the BolA IbaG family
AL537_RS00575	COG2813	Specifically methylates the guanine in position
AL537_RS00580	COG3056	Lipoprotein
AL537_RS00600	COG1595	DNA-templated transcription, initiation
AL537_RS00620	COG3248	Nucleoside-binding outer membrane protein
AL537_RS00625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL537_RS00630	COG0693	protein deglycase activity
AL537_RS00635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL537_RS00640	COG3706	GGDEF domain
AL537_RS00645	COG2166	iron-sulfur cluster assembly
AL537_RS00650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL537_RS00655	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL537_RS00670	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL537_RS00670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL537_RS00680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL537_RS00685	COG1074	ATP-dependent DNA helicase activity
AL537_RS00695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL537_RS00715	COG3141	response to X-ray
AL537_RS00720	COG2171	N-acyltransferase activity
AL537_RS00725	COG0584	glycerophosphoryl diester phosphodiesterase
AL537_RS00730	COG2271	Major facilitator Superfamily
AL537_RS00740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL537_RS00745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL537_RS00750	COG1349	DNA-binding transcription factor activity
AL537_RS00755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL537_RS00775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_RS00780	COG1609	Transcriptional regulator
AL537_RS00785	COG2211	Major facilitator Superfamily
AL537_RS00795	COG1609	Transcriptional regulator
AL537_RS00800	COG2017	converts alpha-aldose to the beta-anomer
AL537_RS00805	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL537_RS00815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL537_RS00825	COG1609	Transcriptional regulator
AL537_RS00830	COG3250	beta-galactosidase activity
AL537_RS00835	COG2731	YhcH YjgK YiaL family protein
AL537_RS00840	COG0531	amino acid
AL537_RS00845	COG0583	DNA-binding transcription factor activity
AL537_RS00905	COG4964	Belongs to the GSP D family
AL537_RS00930	COG2169	Transcriptional regulator
AL537_RS00935	COG1022	Amp-dependent synthetase and ligase
AL537_RS00945	COG0583	DNA-binding transcription factor activity
AL537_RS00950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL537_RS00955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL537_RS00965	COG0560	Phosphoserine phosphatase
AL537_RS00975	COG0813	purine-nucleoside phosphorylase activity
AL537_RS00980	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL537_RS00985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL537_RS01000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL537_RS01005	COG0084	hydrolase, TatD family'
AL537_RS01015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL537_RS01035	COG3153	acetyltransferase
AL537_RS01040	COG3154	lipid carrier protein
AL537_RS01055	COG0826	peptidase U32
AL537_RS01060	COG0826	peptidase U32
AL537_RS01065	COG0534	Mate efflux family protein
AL537_RS01080	COG1185	polyribonucleotide nucleotidyltransferase activity
AL537_RS01085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL537_RS01090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL537_RS01095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL537_RS01100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL537_RS01105	COG0195	Participates in both transcription termination and antitermination
AL537_RS01110	COG0779	Required for maturation of 30S ribosomal subunits
AL537_RS01125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL537_RS01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL537_RS01140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL537_RS01145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL537_RS01150	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL537_RS01155	COG1534	Rna-binding protein
AL537_RS01160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_RS01165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_RS01170	COG2027	D-alanyl-D-alanine carboxypeptidase
AL537_RS01180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL537_RS01185	COG0739	heme binding
AL537_RS01205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL537_RS01210	COG0628	permease
AL537_RS01215	COG2813	Specifically methylates the guanine in position
AL537_RS01220	COG2205	protein histidine kinase activity
AL537_RS01220	COG0784	Response regulator, receiver
AL537_RS01225	COG0747	negative chemotaxis
AL537_RS01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_RS01240	COG0444	Belongs to the ABC transporter superfamily
AL537_RS01245	COG4608	Belongs to the ABC transporter superfamily
AL537_RS01255	COG2971	BadF BadG BcrA BcrD
AL537_RS01270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL537_RS01275	COG3842	ATPase activity
AL537_RS01285	COG1840	ABC-type Fe3 transport system, periplasmic component
AL537_RS01290	COG0004	ammonium transporteR
AL537_RS01295	COG0347	Belongs to the P(II) protein family
AL537_RS01300	COG3112	Uncharacterised protein family (UPF0231)
AL537_RS01305	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL537_RS01310	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL537_RS01315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL537_RS01320	COG1643	Atp-dependent helicase
AL537_RS01325	COG1489	DNA binding
AL537_RS01335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL537_RS01345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL537_RS01350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL537_RS01355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL537_RS01360	COG1560	Kdo2-lipid A biosynthetic process
AL537_RS01370	COG0842	Transport permease protein
AL537_RS01375	COG1131	(ABC) transporter
AL537_RS01380	COG0659	secondary active sulfate transmembrane transporter activity
AL537_RS01385	COG0288	reversible hydration of carbon dioxide
AL537_RS01400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_RS01405	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL537_RS01410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL537_RS01415	COG2186	Transcriptional regulator
AL537_RS01425	COG0157	Belongs to the NadC ModD family
AL537_RS01435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL537_RS01440	COG1459	type II secretion system
AL537_RS01450	COG0237	dephospho-CoA kinase activity
AL537_RS01455	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL537_RS01460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL537_RS01475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL537_RS01480	COG0228	four-way junction DNA binding
AL537_RS01485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL537_RS01490	COG4137	Cytochrome C assembly protein
AL537_RS01495	COG4536	flavin adenine dinucleotide binding
AL537_RS01500	COG1854	S-ribosylhomocysteine lyase activity
AL537_RS01515	COG0612	Peptidase, M16
AL537_RS01520	COG1238	metal cluster binding
AL537_RS01530	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL537_RS01535	COG5016	pyruvate
AL537_RS01535	COG0511	ligase activity, forming carbon-carbon bonds
AL537_RS01540	COG3630	sodium ion export across plasma membrane
AL537_RS01605	COG0527	aspartate kinase activity
AL537_RS01610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL537_RS01615	COG2137	regulation of response to DNA damage stimulus
AL537_RS01620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL537_RS01625	COG1546	Belongs to the CinA family
AL537_RS01630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL537_RS01635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL537_RS01645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL537_RS01650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL537_RS01665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL537_RS01670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL537_RS01675	COG0148	phosphopyruvate hydratase activity
AL537_RS01680	COG0504	CTP synthase activity
AL537_RS01685	COG3956	TIGRFAM MazG family protein
AL537_RS01690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL537_RS01700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL537_RS01715	COG0736	holo-[acyl-carrier-protein] synthase activity
AL537_RS01720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL537_RS01725	COG1381	Involved in DNA repair and RecF pathway recombination
AL537_RS01730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL537_RS01740	COG0681	Belongs to the peptidase S26 family
AL537_RS01745	COG0481	GTPase activity
AL537_RS01750	COG3086	response to oxidative stress
AL537_RS01765	COG1595	DNA-templated transcription, initiation
AL537_RS01775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL537_RS01785	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL537_RS01790	COG0354	folic acid binding
AL537_RS01805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL537_RS01810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL537_RS01815	COG3079	Belongs to the UPF0149 family
AL537_RS01825	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL537_RS01835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL537_RS01840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL537_RS01845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL537_RS01855	COG0583	DNA-binding transcription factor activity
AL537_RS01870	COG0668	transmembrane transport
AL537_RS01875	COG0191	fructose-bisphosphate aldolase activity
AL537_RS01880	COG0126	phosphoglycerate kinase activity
AL537_RS01885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL537_RS01890	COG4771	TonB-dependent receptor
AL537_RS01895	COG0583	DNA-binding transcription factor activity
AL537_RS01900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL537_RS01910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL537_RS01925	COG2356	endonuclease I
AL537_RS01930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL537_RS01935	COG0189	ligase activity
AL537_RS01940	COG1678	Uncharacterized ACR, COG1678
AL537_RS01945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL537_RS01960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL537_RS01965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL537_RS01970	COG0762	integral membrane protein
AL537_RS01975	COG1872	DUF167
AL537_RS01985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL537_RS01990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL537_RS01995	COG2066	Belongs to the glutaminase family
AL537_RS02005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL537_RS02015	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL537_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
AL537_RS02140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL537_RS02150	COG3394	polysaccharide catabolic process
AL537_RS02155	COG1486	melibiose metabolic process
AL537_RS02160	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL537_RS02165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL537_RS02170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL537_RS02175	COG0726	polysaccharide deacetylase
AL537_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS02200	COG0795	lipopolysaccharide-transporting ATPase activity
AL537_RS02205	COG0795	lipopolysaccharide-transporting ATPase activity
AL537_RS02215	COG2927	DNA polymerase III (CHI subunit)
AL537_RS02220	COG0525	valine-tRNA ligase activity
AL537_RS02260	COG0540	Belongs to the ATCase OTCase family
AL537_RS02265	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL537_RS02270	COG0251	oxidation-reduction process
AL537_RS02275	COG0204	Acyl-transferase
AL537_RS02285	COG5007	Belongs to the BolA IbaG family
AL537_RS02295	COG2854	intermembrane phospholipid transfer
AL537_RS02300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL537_RS02305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL537_RS02310	COG1127	ABC transporter
AL537_RS02320	COG0517	IMP dehydrogenase activity
AL537_RS02320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL537_RS02330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL537_RS02335	COG1137	ATPase activity
AL537_RS02345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL537_RS02350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS02355	COG1660	Displays ATPase and GTPase activities
AL537_RS02360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS02365	COG2239	Acts as a magnesium transporter
AL537_RS02370	COG0312	modulator of DNA gyrase
AL537_RS02375	COG3028	Belongs to the UPF0307 family
AL537_RS02380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL537_RS02385	COG0564	pseudouridine synthase activity
AL537_RS02395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL537_RS02400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL537_RS02405	COG0312	modulator of DNA gyrase
AL537_RS02410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL537_RS02415	COG3164	Protein of unknown function
AL537_RS02425	COG0424	maF-like protein
AL537_RS02430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL537_RS02435	COG1792	Involved in formation and maintenance of cell shape
AL537_RS02440	COG1077	Cell shape determining protein MreB Mrl
AL537_RS02475	COG2165	general secretion pathway protein
AL537_RS02485	COG1459	type II secretion system
AL537_RS02490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL537_RS02500	COG3409	Peptidoglycan-binding domain 1 protein
AL537_RS02500	COG3267	Type II secretory pathway component ExeA
AL537_RS02505	COG1450	Type ii and iii secretion system protein
AL537_RS02525	COG2199	diguanylate cyclase activity
AL537_RS02525	COG2200	EAL domain
AL537_RS02530	COG0629	single-stranded DNA binding
AL537_RS02545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL537_RS02555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL537_RS02565	COG0527	aspartate kinase activity
AL537_RS02570	COG1410	methionine synthase
AL537_RS02570	COG0646	methionine synthase
AL537_RS02635	COG0175	sulfate reduction
AL537_RS02640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_RS02645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL537_RS02665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL537_RS02670	COG0735	belongs to the Fur family
AL537_RS02680	COG0166	Belongs to the GPI family
AL537_RS02685	COG0432	Pfam Uncharacterised protein family UPF0047
AL537_RS02690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL537_RS02715	COG2965	DNA replication, synthesis of RNA primer
AL537_RS02720	COG0360	Binds together with S18 to 16S ribosomal RNA
AL537_RS02725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL537_RS02730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL537_RS02740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL537_RS02745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL537_RS02775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL537_RS02790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL537_RS02790	COG0678	peroxiredoxin activity
AL537_RS02795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_RS02810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL537_RS02810	COG0165	Argininosuccinate lyase
AL537_RS02815	COG0137	argininosuccinate synthase activity
AL537_RS02825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL537_RS02835	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL537_RS02845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL537_RS02850	COG0527	aspartate kinase activity
AL537_RS02850	COG0460	homoserine dehydrogenase
AL537_RS02855	COG0626	cystathionine gamma-synthase activity
AL537_RS02860	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL537_RS02865	COG0281	malic enzyme
AL537_RS02875	COG2906	2 iron, 2 sulfur cluster binding
AL537_RS02880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL537_RS02885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL537_RS02900	COG2168	tRNA wobble position uridine thiolation
AL537_RS02905	COG2923	Belongs to the DsrF TusC family
AL537_RS02910	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL537_RS02915	COG2964	Protein conserved in bacteria
AL537_RS02920	COG0545	Peptidyl-prolyl cis-trans isomerase
AL537_RS02935	COG1446	asparaginase
AL537_RS02940	COG1047	Peptidyl-prolyl cis-trans
AL537_RS02955	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL537_RS02960	COG0488	(ABC) transporter
AL537_RS02970	COG0429	hydrolase of the alpha beta-hydrolase fold
AL537_RS02975	COG3089	Belongs to the UPF0270 family
AL537_RS02980	COG3954	Phosphoribulokinase
AL537_RS02985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_RS03005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL537_RS03010	COG0512	Glutamine amidotransferase of anthranilate synthase
AL537_RS03025	COG0180	Tryptophanyl-tRNA synthetase
AL537_RS03030	COG0546	phosphoglycolate phosphatase activity
AL537_RS03035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL537_RS03040	COG0557	exoribonuclease II activity
AL537_RS03045	COG1959	2 iron, 2 sulfur cluster binding
AL537_RS03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL537_RS03050	COG1017	nitric oxide dioxygenase activity
AL537_RS03055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL537_RS03065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL537_RS03070	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL537_RS03075	COG0330	HflC and HflK could
AL537_RS03080	COG0330	HflC and HflK could
AL537_RS03085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL537_RS03095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL537_RS03100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL537_RS03110	COG0802	atpase or kinase
AL537_RS03120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL537_RS03185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL537_RS03190	COG1162	GTPase activity
AL537_RS03195	COG0688	phosphatidylethanolamine metabolic process
AL537_RS03200	COG3273	potassium ion transport
AL537_RS03200	COG0471	metal ion transport
AL537_RS03210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL537_RS03215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_RS03220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL537_RS03225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL537_RS03230	COG1045	serine acetyltransferase
AL537_RS03235	COG4942	peptidase
AL537_RS03255	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL537_RS03260	COG1053	succinate dehydrogenase
AL537_RS03265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL537_RS03270	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL537_RS03290	COG1509	lysine 2,3-aminomutase activity
AL537_RS03295	COG1285	pathogenesis
AL537_RS03305	COG0459	protein refolding
AL537_RS03315	COG0534	Mate efflux family protein
AL537_RS03320	COG0205	6-phosphofructokinase activity
AL537_RS03325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL537_RS03330	COG3678	ATP-independent chaperone mediated protein folding
AL537_RS03335	COG0745	RESPONSE REGULATOR receiver
AL537_RS03340	COG2205	protein histidine kinase activity
AL537_RS03350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL537_RS03360	COG1027	Aspartate ammonia-lyase
AL537_RS03365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL537_RS03370	COG4232	protein-disulfide reductase activity
AL537_RS03380	COG3263	regulation of cellular component size
AL537_RS03390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL537_RS03415	COG2814	Major facilitator Superfamily
AL537_RS03430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL537_RS03435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL537_RS03440	COG0511	ligase activity, forming carbon-carbon bonds
AL537_RS03445	COG0439	Biotin carboxylase
AL537_RS03455	COG2264	protein methyltransferase activity
AL537_RS03460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL537_RS03465	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL537_RS03475	COG0488	(ABC) transporter
AL537_RS03530	COG1982	Orn Lys Arg decarboxylase major
AL537_RS03535	COG0531	amino acid
AL537_RS03545	COG3710	Transcriptional regulator
AL537_RS03550	COG0789	Transcriptional regulator
AL537_RS03560	COG0138	bifunctional purine biosynthesis protein purh
AL537_RS03570	COG0151	Belongs to the GarS family
AL537_RS03585	COG1253	flavin adenine dinucleotide binding
AL537_RS03590	COG3068	Protein conserved in bacteria
AL537_RS03600	COG1573	uracil-dna glycosylase
AL537_RS03605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL537_RS03610	COG2816	NAD+ diphosphatase activity
AL537_RS03615	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL537_RS03620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL537_RS03625	COG0085	RNA polymerase activity
AL537_RS03630	COG0222	ribosome binding
AL537_RS03635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL537_RS03650	COG0250	Participates in transcription elongation, termination and antitermination
AL537_RS03655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL537_RS03665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL537_RS03700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL537_RS03700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL537_RS03705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL537_RS03715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL537_RS03795	COG4206	TonB-dependent receptor
AL537_RS03815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_RS03820	COG0534	Mate efflux family protein
AL537_RS03825	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL537_RS03835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL537_RS03845	COG2937	Belongs to the GPAT DAPAT family
AL537_RS03850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL537_RS03855	COG3161	chorismate lyase activity
AL537_RS03860	COG1580	Controls the rotational direction of flagella during chemotaxis
AL537_RS03865	COG0705	Rhomboid family
AL537_RS03870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_RS03885	COG2177	Part of the ABC transporter FtsEX involved in
AL537_RS03890	COG2884	Cell division ATP-binding protein ftsE
AL537_RS03895	COG0552	protein localization to endoplasmic reticulum
AL537_RS03900	COG0742	ribosomal rna small subunit methyltransferase
AL537_RS03910	COG2095	MarC family integral membrane protein
AL537_RS03960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL537_RS03965	COG0640	Transcriptional regulator
AL537_RS03970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL537_RS03975	COG1280	lysine exporter protein (LysE YggA)
AL537_RS03980	COG2267	carboxylic ester hydrolase activity
AL537_RS03985	COG0561	phosphatase activity
AL537_RS04000	COG3148	PFAM DTW domain containing protein
AL537_RS04005	COG3287	FIST C domain
AL537_RS04005	COG2199	diguanylate cyclase activity
AL537_RS04005	COG2200	EAL domain
AL537_RS04010	COG1011	Hydrolase
AL537_RS04015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL537_RS04025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL537_RS04030	COG0019	diaminopimelate decarboxylase activity
AL537_RS04040	COG1965	Belongs to the frataxin family
AL537_RS04045	COG3072	Adenylate cyclase
AL537_RS04050	COG0181	hydroxymethylbilane synthase activity
AL537_RS04055	COG1587	Uroporphyrinogen-III synthase
AL537_RS04060	COG2959	enzyme of heme biosynthesis
AL537_RS04065	COG3071	HemY protein
AL537_RS04110	COG0633	Ferredoxin
AL537_RS04115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL537_RS04135	COG3118	belongs to the thioredoxin family
AL537_RS04140	COG0513	Belongs to the DEAD box helicase family
AL537_RS04145	COG0248	Ppx GppA phosphatase
AL537_RS04150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL537_RS04160	COG0514	ATP-dependent DNA helicase (RecQ)
AL537_RS04165	COG2962	Rard protein
AL537_RS04175	COG1280	lysine exporter protein (LysE YggA)
AL537_RS04180	COG0405	Gamma-glutamyltransferase
AL537_RS04185	COG0210	DNA helicase
AL537_RS04195	COG3220	belongs to the UPF0276 family
AL537_RS04225	COG0006	proline dipeptidase activity
AL537_RS04225	COG0006	proline dipeptidase activity
AL537_RS04245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL537_RS04260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL537_RS04320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL537_RS04330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL537_RS04335	COG0408	coproporphyrinogen oxidase activity
AL537_RS04340	COG0009	L-threonylcarbamoyladenylate synthase
AL537_RS04345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL537_RS04350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL537_RS04355	COG0551	DNA topoisomerase type I activity
AL537_RS04360	COG2922	Belongs to the Smg family
AL537_RS04365	COG0758	DNA mediated transformation
AL537_RS04375	COG0242	peptide deformylase activity
AL537_RS04380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL537_RS04385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL537_RS04385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL537_RS04390	COG0569	domain protein
AL537_RS04395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_RS04405	COG1272	protein, Hemolysin III
AL537_RS04410	COG4326	sporulation control protein
AL537_RS04420	COG3084	Protein conserved in bacteria
AL537_RS04430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL537_RS04435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL537_RS04440	COG0204	Acyl-transferase
AL537_RS04450	COG0606	chelatase, subunit chli
AL537_RS04460	COG3978	acetolactate synthase activity
AL537_RS04465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL537_RS04470	COG0129	dihydroxy-acid dehydratase activity
AL537_RS04480	COG0583	DNA-binding transcription factor activity
AL537_RS04485	COG2814	Major facilitator Superfamily
AL537_RS04495	COG0765	amino acid transport
AL537_RS04505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL537_RS04510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL537_RS04515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL537_RS04520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL537_RS04525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL537_RS04530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL537_RS04540	COG0356	it plays a direct role in the translocation of protons across the membrane
AL537_RS04545	COG3312	ion transport
AL537_RS04550	COG1475	DNA binding
AL537_RS04555	COG1192	Involved in chromosome partitioning
AL537_RS04560	COG0357	Ribosomal RNA small subunit methyltransferase G
AL537_RS04565	COG0445	tRNA wobble uridine modification
AL537_RS04570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL537_RS04580	COG0706	membrane insertase activity
AL537_RS04590	COG0594	ribonuclease P activity
AL537_RS04600	COG1126	abc transporter atp-binding protein
AL537_RS04620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL537_RS04625	COG0592	DNA-directed DNA polymerase activity
AL537_RS04635	COG0187	DNA topoisomerase II activity
AL537_RS04650	COG0071	Belongs to the small heat shock protein (HSP20) family
AL537_RS04655	COG3977	Valine--pyruvate aminotransferase
AL537_RS04660	COG0366	Alpha amylase catalytic
AL537_RS04665	COG0751	glycine-tRNA ligase activity
AL537_RS04675	COG2119	membrane
AL537_RS04685	COG0425	Belongs to the sulfur carrier protein TusA family
AL537_RS04700	COG0604	alcohol dehydrogenase
AL537_RS04705	COG0183	Belongs to the thiolase family
AL537_RS04715	COG1739	Uncharacterized protein family UPF0029
AL537_RS04720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_RS04765	COG0583	DNA-binding transcription factor activity
AL537_RS04770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL537_RS04775	COG2960	long-chain fatty acid transporting porin activity
AL537_RS04780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_RS04785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_RS04845	COG4166	transmembrane transport
AL537_RS04850	COG0601	transmembrane transport
AL537_RS04855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_RS04895	COG1609	Transcriptional regulator
AL537_RS04900	COG0583	DNA-binding transcription factor activity
AL537_RS04915	COG0129	dihydroxy-acid dehydratase activity
AL537_RS04920	COG3265	gluconokinase activity
AL537_RS04925	COG2610	gluconate transmembrane transporter activity
AL537_RS04930	COG0800	Aldolase
AL537_RS04935	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL537_RS04940	COG0583	DNA-binding transcription factor activity
AL537_RS04945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL537_RS04950	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL537_RS04960	COG1522	sequence-specific DNA binding
AL537_RS04965	COG5002	protein histidine kinase activity
AL537_RS04965	COG5001	Diguanylate cyclase
AL537_RS04970	COG0742	ribosomal rna small subunit methyltransferase
AL537_RS04985	COG0589	response to stress
AL537_RS04990	COG1528	Iron-storage protein
AL537_RS05000	COG2081	HI0933 family
AL537_RS05030	COG1597	lipid kinase activity
AL537_RS05060	COG0628	permease
AL537_RS05075	COG1322	Protein conserved in bacteria
AL537_RS05080	COG2226	methyltransferase
AL537_RS05085	COG3165	ubiquinone biosynthetic process from chorismate
AL537_RS05090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL537_RS05100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL537_RS05105	COG0805	protein transport
AL537_RS05115	COG0084	hydrolase, TatD family'
AL537_RS05130	COG0456	acetyltransferase
AL537_RS05140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_RS05140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_RS05145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL537_RS05180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL537_RS05190	COG2204	response regulator
AL537_RS05195	COG3852	Histidine kinase
AL537_RS05205	COG0174	glutamine synthetase
AL537_RS05210	COG1217	gtp-binding protein TYPA
AL537_RS05230	COG1295	ribonuclease BN
AL537_RS05235	COG1490	D-aminoacyl-tRNA deacylase activity
AL537_RS05240	COG0456	acetyltransferase
AL537_RS05250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL537_RS05255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL537_RS05260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL537_RS05265	COG3031	protein transport across the cell outer membrane
AL537_RS05275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL537_RS05280	COG1459	type II secretion system
AL537_RS05285	COG2165	general secretion pathway protein
AL537_RS05290	COG2165	general secretion pathway protein
AL537_RS05295	COG2165	general secretion pathway protein
AL537_RS05300	COG4795	General secretion pathway protein
AL537_RS05305	COG3156	type II secretion system protein K
AL537_RS05310	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL537_RS05315	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL537_RS05325	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL537_RS05330	COG0494	nUDIX hydrolase
AL537_RS05335	COG0316	Belongs to the HesB IscA family
AL537_RS05335	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL537_RS05340	COG1040	competence protein
AL537_RS05345	COG0596	Alpha beta hydrolase
AL537_RS05355	COG2183	response to ionizing radiation
AL537_RS05365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_RS05385	COG2233	PERMEase
AL537_RS05390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL537_RS05395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL537_RS05400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL537_RS05405	COG1758	RNA polymerase activity
AL537_RS05410	COG0194	GDP metabolic process
AL537_RS05425	COG0848	biopolymer transport protein
AL537_RS05430	COG0811	peptide transport
AL537_RS05455	COG4174	ABC transporter (Permease)
AL537_RS05460	COG4239	(ABC) transporter, permease
AL537_RS05465	COG0747	negative chemotaxis
AL537_RS05470	COG0444	Belongs to the ABC transporter superfamily
AL537_RS05475	COG4608	Belongs to the ABC transporter superfamily
AL537_RS05485	COG1561	YicC-like family, N-terminal region
AL537_RS05495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL537_RS05500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL537_RS05505	COG1560	Kdo2-lipid A biosynthetic process
AL537_RS05510	COG1309	transcriptional regulator
AL537_RS05515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL537_RS05525	COG2003	Belongs to the UPF0758 family
AL537_RS05555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL537_RS05570	COG0463	Glycosyl transferase, family 2
AL537_RS05575	COG0859	PFAM glycosyl transferase family 9
AL537_RS05580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL537_RS05585	COG3642	lipopolysaccharide core region biosynthetic process
AL537_RS05590	COG1086	Polysaccharide biosynthesis protein
AL537_RS05595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL537_RS05600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL537_RS05605	COG2089	acid synthase
AL537_RS05620	COG1083	cytidylyl-transferase
AL537_RS05635	COG1519	Transferase
AL537_RS05640	COG0859	PFAM glycosyl transferase family 9
AL537_RS05645	COG1560	Kdo2-lipid A biosynthetic process
AL537_RS05655	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_RS05690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL537_RS05695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL537_RS05705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AL537_RS05725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL537_RS05760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL537_RS05765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL537_RS05770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL537_RS05775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL537_RS05785	COG0110	maltose O-acetyltransferase activity
AL537_RS05805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL537_RS05815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL537_RS05835	COG0149	triose-phosphate isomerase activity
AL537_RS05865	COG1494	fructose-1,6-bisphosphatase
AL537_RS05880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL537_RS05885	COG1575	Belongs to the MenA family. Type 1 subfamily
AL537_RS05890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL537_RS05895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL537_RS05905	COG1609	Transcriptional regulator
AL537_RS05910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL537_RS05920	COG0254	rRNA binding
AL537_RS05930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL537_RS05935	COG0088	Forms part of the polypeptide exit tunnel
AL537_RS05945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL537_RS05950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL537_RS05955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL537_RS05960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL537_RS05970	COG0255	Belongs to the universal ribosomal protein uL29 family
AL537_RS05975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL537_RS05985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL537_RS05990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL537_RS05995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL537_RS06000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL537_RS06005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL537_RS06020	COG1841	ribosomal large subunit assembly
AL537_RS06025	COG0200	Binds to the 23S rRNA
AL537_RS06030	COG0201	protein transport
AL537_RS06035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL537_RS06040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL537_RS06045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL537_RS06055	COG0202	RNA polymerase activity
AL537_RS06060	COG0203	ribosomal protein L17
AL537_RS06070	COG0545	Peptidyl-prolyl cis-trans isomerase
AL537_RS06080	COG2153	protein acetylation
AL537_RS06085	COG0513	Belongs to the DEAD box helicase family
AL537_RS06100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL537_RS06100	COG1648	precorrin-2 dehydrogenase activity
AL537_RS06105	COG0175	sulfate reduction
AL537_RS06110	COG2895	sulfate adenylyltransferase (ATP) activity
AL537_RS06115	COG3273	potassium ion transport
AL537_RS06115	COG0471	metal ion transport
AL537_RS06120	COG0529	Catalyzes the synthesis of activated sulfate
AL537_RS06140	COG4181	ATPase activity
AL537_RS06155	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL537_RS06165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_RS06170	COG0729	surface antigen
AL537_RS06175	COG2911	Protein conserved in bacteria
AL537_RS06180	COG2105	PFAM AIG2 family protein
AL537_RS06190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL537_RS06195	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL537_RS06205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL537_RS06210	COG0163	prenyltransferase activity
AL537_RS06215	COG4143	(ABC) transporter
AL537_RS06220	COG1178	ABC-type Fe3 transport system permease component
AL537_RS06225	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL537_RS06230	COG0583	DNA-binding transcription factor activity
AL537_RS06235	COG1902	pentaerythritol trinitrate reductase activity
AL537_RS06255	COG2358	TRAP transporter, solute receptor (TAXI family
AL537_RS06280	COG0142	geranyltranstransferase activity
AL537_RS06285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL537_RS06295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL537_RS06300	COG2966	Psort location CytoplasmicMembrane, score
AL537_RS06315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL537_RS06320	COG2967	ApaG domain
AL537_RS06325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL537_RS06330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL537_RS06335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL537_RS06340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL537_RS06345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL537_RS06365	COG0473	3-isopropylmalate dehydrogenase activity
AL537_RS06370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL537_RS06395	COG0583	DNA-binding transcription factor activity
AL537_RS06400	COG1022	Amp-dependent synthetase and ligase
AL537_RS06405	COG0028	Belongs to the TPP enzyme family
AL537_RS06425	COG0469	pyruvate kinase activity
AL537_RS06435	COG1349	DNA-binding transcription factor activity
AL537_RS06440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL537_RS06455	COG5002	protein histidine kinase activity
AL537_RS06465	COG2376	Dihydroxyacetone kinase
AL537_RS06470	COG1461	Dihydroxyacetone kinase
AL537_RS06485	COG3722	fumarate hydratase activity
AL537_RS06495	COG2213	PTS system mannitol-specific
AL537_RS06495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS06545	COG0358	DNA primase activity
AL537_RS06550	COG1610	YqeY-like protein
AL537_RS06555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL537_RS06560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL537_RS06565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL537_RS06570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL537_RS06575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL537_RS06580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL537_RS06585	COG1968	undecaprenyl-diphosphatase activity
AL537_RS06590	COG0617	tRNA 3'-terminal CCA addition
AL537_RS06595	COG3267	Type II secretory pathway component ExeA
AL537_RS06595	COG3409	Peptidoglycan-binding domain 1 protein
AL537_RS06605	COG0405	Gamma-glutamyltransferase
AL537_RS06610	COG4991	sh3 domain protein
AL537_RS06615	COG0306	phosphate transporter
AL537_RS06620	COG1392	Phosphate transport regulator
AL537_RS06625	COG3025	triphosphatase activity
AL537_RS06640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL537_RS06645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL537_RS06645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL537_RS06650	COG1538	Outer membrane efflux protein
AL537_RS06655	COG0494	nUDIX hydrolase
AL537_RS06660	COG3151	Protein conserved in bacteria
AL537_RS06670	COG3150	esterase
AL537_RS06680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL537_RS06685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL537_RS06695	COG3105	Protein conserved in bacteria
AL537_RS06705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL537_RS06715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL537_RS06720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL537_RS06725	COG0723	plastoquinol--plastocyanin reductase activity
AL537_RS06730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL537_RS06735	COG2857	Cytochrome c1
AL537_RS06740	COG0625	glutathione transferase activity
AL537_RS06745	COG2969	positive regulation of protein catabolic process
AL537_RS06750	COG2823	Periplasmic or secreted lipoprotein
AL537_RS06755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL537_RS06770	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL537_RS06785	COG3116	cell division
AL537_RS06790	COG0768	penicillin binding
AL537_RS06795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL537_RS06800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL537_RS06805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL537_RS06810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL537_RS06815	COG0772	Belongs to the SEDS family
AL537_RS06825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL537_RS06830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL537_RS06835	COG0849	cell division
AL537_RS06840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL537_RS06845	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL537_RS06855	COG0653	protein targeting
AL537_RS06860	COG0494	nUDIX hydrolase
AL537_RS06870	COG0505	Belongs to the CarA family
AL537_RS06875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL537_RS06895	COG0730	response to heat
AL537_RS06905	COG0583	DNA-binding transcription factor activity
AL537_RS06910	COG2860	membrane
AL537_RS06925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL537_RS06935	COG0493	'glutamate synthase
AL537_RS06940	COG0070	glutamate synthase
AL537_RS06940	COG0069	glutamate synthase activity
AL537_RS06940	COG0067	glutamate synthase
AL537_RS06950	COG0070	glutamate synthase
AL537_RS06950	COG0069	glutamate synthase activity
AL537_RS06950	COG0067	glutamate synthase
AL537_RS06955	COG1242	4 iron, 4 sulfur cluster binding
AL537_RS06960	COG4251	negative regulation of phosphorylation
AL537_RS06960	COG5001	Diguanylate cyclase
AL537_RS06960	COG2203	Gaf domain
AL537_RS06960	COG3706	GGDEF domain
AL537_RS06965	COG5002	protein histidine kinase activity
AL537_RS06965	COG2198	Histidine kinase
AL537_RS06965	COG0784	Response regulator, receiver
AL537_RS06975	COG0745	RESPONSE REGULATOR receiver
AL537_RS06990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL537_RS07010	COG0083	homoserine kinase activity
AL537_RS07015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL537_RS07025	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL537_RS07030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL537_RS07040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL537_RS07055	COG1115	amino acid carrier protein
AL537_RS07060	COG3022	response to hydroperoxide
AL537_RS07065	COG0513	Belongs to the DEAD box helicase family
AL537_RS07070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL537_RS07080	COG0716	FMN binding
AL537_RS07085	COG4974	Belongs to the 'phage' integrase family
AL537_RS07090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL537_RS07095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL537_RS07105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL537_RS07110	COG2204	response regulator
AL537_RS07120	COG0667	Aldo Keto reductase
AL537_RS07145	COG0730	response to heat
AL537_RS07150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL537_RS07155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL537_RS07165	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL537_RS07170	COG0583	DNA-binding transcription factor activity
AL537_RS07175	COG0640	Transcriptional regulator
AL537_RS07180	COG0268	Binds directly to 16S ribosomal RNA
AL537_RS07185	COG0728	peptidoglycan biosynthetic process
AL537_RS07190	COG0196	riboflavin kinase activity
AL537_RS07200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL537_RS07205	COG1047	Peptidyl-prolyl cis-trans
AL537_RS07210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL537_RS07220	COG3279	Response regulator of the LytR AlgR family
AL537_RS07225	COG3275	phosphorelay sensor kinase activity
AL537_RS07230	COG1966	Carbon starvation protein
AL537_RS07250	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL537_RS07255	COG1472	Belongs to the glycosyl hydrolase 3 family
AL537_RS07260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL537_RS07265	COG1605	Chorismate mutase
AL537_RS07265	COG0287	Prephenate dehydrogenase
AL537_RS07270	COG1196	nuclear chromosome segregation
AL537_RS07270	COG0741	lytic transglycosylase activity
AL537_RS07270	COG0739	heme binding
AL537_RS07280	COG0488	(ABC) transporter
AL537_RS07290	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL537_RS07295	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL537_RS07300	COG0077	Prephenate dehydratase
AL537_RS07300	COG1605	Chorismate mutase
AL537_RS07305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL537_RS07310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL537_RS07315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_RS07320	COG0564	pseudouridine synthase activity
AL537_RS07330	COG0542	response to heat
AL537_RS07390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL537_RS07395	COG0826	peptidase U32
AL537_RS07400	COG2974	May be involved in recombination
AL537_RS07410	COG0745	RESPONSE REGULATOR receiver
AL537_RS07415	COG5002	protein histidine kinase activity
AL537_RS07425	COG0248	Ppx GppA phosphatase
AL537_RS07430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL537_RS07435	COG0573	inorganic phosphate transmembrane transporter activity
AL537_RS07440	COG0581	inorganic phosphate transmembrane transporter activity
AL537_RS07445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL537_RS07450	COG0704	Plays a role in the regulation of phosphate uptake
AL537_RS07460	COG3142	Participates in the control of copper homeostasis
AL537_RS07465	COG0450	alkyl hydroperoxide reductase
AL537_RS07470	COG0583	DNA-binding transcription factor activity
AL537_RS07475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL537_RS07485	COG0517	IMP dehydrogenase activity
AL537_RS07500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL537_RS07510	COG1862	Preprotein translocase
AL537_RS07515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_RS07520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_RS07525	COG0483	inositol monophosphate 1-phosphatase activity
AL537_RS07530	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL537_RS07540	COG1104	cysteine desulfurase activity
AL537_RS07545	COG0822	iron-sulfur transferase activity
AL537_RS07560	COG0443	Heat shock 70 kDa protein
AL537_RS07565	COG0633	Ferredoxin
AL537_RS07570	COG2975	iron-sulfur cluster assembly
AL537_RS07580	COG0105	UTP biosynthetic process
AL537_RS07600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL537_RS07605	COG0124	histidyl-tRNA synthetase
AL537_RS07610	COG2976	Protein conserved in bacteria
AL537_RS07615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_RS07620	COG1160	GTP binding
AL537_RS07640	COG0517	IMP dehydrogenase activity
AL537_RS07640	COG0516	GMP reductase activity
AL537_RS07645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL537_RS07645	COG0519	Catalyzes the synthesis of GMP from XMP
AL537_RS07650	COG1757	Na H antiporter
AL537_RS07660	COG1584	GPR1 FUN34 yaaH family protein
AL537_RS07665	COG1115	amino acid carrier protein
AL537_RS07690	COG2873	o-acetylhomoserine
AL537_RS07695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL537_RS07715	COG3153	acetyltransferase
AL537_RS07715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL537_RS07720	COG0583	DNA-binding transcription factor activity
AL537_RS07730	COG2801	Transposase and inactivated derivatives
AL537_RS07735	COG0583	DNA-binding transcription factor activity
AL537_RS07785	COG0210	DNA helicase
AL537_RS07820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL537_RS07845	COG0582	viral genome integration into host DNA
AL537_RS07855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL537_RS07860	COG2867	negative regulation of translational initiation
AL537_RS07865	COG2914	Belongs to the UPF0125 (RnfH) family
AL537_RS07870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL537_RS07875	COG0497	DNA recombination
AL537_RS07885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL537_RS07890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL537_RS07895	COG1301	dicarboxylic acid transport
AL537_RS07905	COG0484	heat shock protein binding
AL537_RS07915	COG4969	Belongs to the N-Me-Phe pilin family
AL537_RS07940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL537_RS07955	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL537_RS07960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL537_RS07960	COG0047	phosphoribosylformylglycinamidine synthase activity
AL537_RS07975	COG1629	transport
AL537_RS07990	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL537_RS07995	COG2252	PERMEase
AL537_RS08000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL537_RS08005	COG1073	alpha beta
AL537_RS08015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL537_RS08020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL537_RS08025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL537_RS08030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_RS08030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_RS08045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL537_RS08055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL537_RS08060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL537_RS08065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL537_RS08070	COG0142	geranyltranstransferase activity
AL537_RS08075	COG1722	exodeoxyribonuclease VII activity
AL537_RS08080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL537_RS08090	COG0301	tRNA thio-modification
AL537_RS08090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_RS08095	COG0583	DNA-binding transcription factor activity
AL537_RS08105	COG2363	Small membrane protein
AL537_RS08115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_RS08120	COG1611	Belongs to the LOG family
AL537_RS08135	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL537_RS08135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL537_RS08145	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL537_RS08150	COG1464	Belongs to the NlpA lipoprotein family
AL537_RS08155	COG2011	ABC-type metal ion transport system permease component
AL537_RS08160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL537_RS08165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL537_RS08175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_RS08175	COG1263	PTS System
AL537_RS08180	COG0366	Alpha amylase catalytic
AL537_RS08195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL537_RS08200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL537_RS08205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL537_RS08210	COG0321	lipoyl(octanoyl) transferase activity
AL537_RS08220	COG1686	Belongs to the peptidase S11 family
AL537_RS08225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL537_RS08230	COG0772	Belongs to the SEDS family
AL537_RS08235	COG0768	penicillin binding
AL537_RS08240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL537_RS08245	COG0799	negative regulation of ribosome biogenesis
AL537_RS08250	COG1466	dna polymerase III delta subunit
AL537_RS08255	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL537_RS08260	COG0495	leucyl-tRNA aminoacylation
AL537_RS08265	COG2888	peptidyl-tyrosine sulfation
AL537_RS08270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL537_RS08275	COG4535	Mg2 and Co2 transporter CorC
AL537_RS08280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL537_RS08285	COG1702	phosphate starvation-inducible protein PhoH
AL537_RS08290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL537_RS08300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL537_RS08410	COG0012	GTP binding
AL537_RS08415	COG0193	aminoacyl-tRNA hydrolase activity
AL537_RS08420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL537_RS08425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL537_RS08430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL537_RS08435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL537_RS08445	COG2890	protein-(glutamine-N5) methyltransferase activity
AL537_RS08450	COG3094	Invasion gene expression up-regulator, SirB
AL537_RS08455	COG2912	Transglutaminase-like superfamily
AL537_RS08460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL537_RS08465	COG0737	Belongs to the 5'-nucleotidase family
AL537_RS08475	COG1187	pseudouridine synthase activity
AL537_RS08480	COG2840	Smr protein MutS2
AL537_RS08520	COG2217	Heavy metal translocating P-type atpase
AL537_RS08520	COG2608	mercury ion transmembrane transporter activity
AL537_RS08540	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL537_RS08595	COG0784	Response regulator, receiver
AL537_RS08595	COG0835	chemotaxis
AL537_RS08600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL537_RS08605	COG1815	bacterial-type flagellum-dependent cell motility
AL537_RS08610	COG1558	bacterial-type flagellum-dependent cell motility
AL537_RS08620	COG1749	Flagellar hook protein flgE
AL537_RS08625	COG4787	bacterial-type flagellum-dependent cell motility
AL537_RS08635	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL537_RS08640	COG1706	bacterial-type flagellum-dependent cell motility
AL537_RS08645	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL537_RS08645	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL537_RS08655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS08660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS08675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS08680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS08685	COG2190	(PTS) system
AL537_RS08690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL537_RS08695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS08705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL537_RS08710	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL537_RS08715	COG3115	cell septum assembly
AL537_RS08720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL537_RS08745	COG0330	HflC and HflK could
AL537_RS08750	COG3118	belongs to the thioredoxin family
AL537_RS08760	COG0300	oxidoreductase activity
AL537_RS08765	COG1090	epimerase
AL537_RS08795	COG0622	Phosphoesterase
AL537_RS08815	COG3710	Transcriptional regulator
AL537_RS08820	COG0326	Molecular chaperone. Has ATPase activity
AL537_RS08830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL537_RS08835	COG3104	oligopeptide transport
AL537_RS08840	COG0250	Participates in transcription elongation, termination and antitermination
AL537_RS08845	COG0367	asparagine synthase
AL537_RS08850	COG4651	solute:proton antiporter activity
AL537_RS08850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL537_RS08855	COG1940	carbohydrate kinase activity
AL537_RS08855	COG1846	Transcriptional regulator
AL537_RS08860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL537_RS08870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_RS08870	COG1263	PTS System
AL537_RS08870	COG2190	(PTS) system
AL537_RS08875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL537_RS08880	COG0735	belongs to the Fur family
AL537_RS08890	COG0716	FMN binding
AL537_RS08900	COG0596	Alpha beta hydrolase
AL537_RS08905	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL537_RS08910	COG0033	Phosphoglucomutase
AL537_RS08920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL537_RS08935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL537_RS08940	COG1053	succinate dehydrogenase
AL537_RS08945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL537_RS08950	COG0567	Dehydrogenase, E1 component
AL537_RS08955	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL537_RS08970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL537_RS08975	COG1121	(ABC) transporter
AL537_RS08980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL537_RS08985	COG4977	sequence-specific DNA binding
AL537_RS08990	COG1918	ferrous iron import across plasma membrane
AL537_RS09010	COG0018	arginyl-trna synthetase
AL537_RS09020	COG3102	Protein conserved in bacteria
AL537_RS09035	COG0788	formyltetrahydrofolate deformylase activity
AL537_RS09040	COG1199	ATP-dependent helicase activity
AL537_RS09045	COG1214	PFAM Peptidase M22, glycoprotease
AL537_RS09055	COG3065	identical protein binding
AL537_RS09060	COG2267	carboxylic ester hydrolase activity
AL537_RS09065	COG0318	PFAM AMP-dependent synthetase and ligase
AL537_RS09070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL537_RS09075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL537_RS09080	COG2894	cell division
AL537_RS09085	COG0850	regulation of cytokinetic process
AL537_RS09090	COG3100	YcgL domain-containing protein
AL537_RS09095	COG2951	lytic endotransglycosylase activity
AL537_RS09105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL537_RS09110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL537_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS09140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL537_RS09165	COG2986	histidine ammonia-lyase
AL537_RS09170	COG1216	Glycosyl transferase, family 2
AL537_RS09175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL537_RS09190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL537_RS09195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL537_RS09230	COG1253	flavin adenine dinucleotide binding
AL537_RS09235	COG0513	Belongs to the DEAD box helicase family
AL537_RS09240	COG0569	domain protein
AL537_RS09245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_RS09260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL537_RS09265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL537_RS09270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL537_RS09275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL537_RS09300	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL537_RS09310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL537_RS09315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL537_RS09320	COG0776	regulation of translation
AL537_RS09325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL537_RS09330	COG1555	photosystem II stabilization
AL537_RS09345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL537_RS09350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL537_RS09355	COG0436	Aminotransferase
AL537_RS09360	COG1169	isochorismate synthase
AL537_RS09365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL537_RS09370	COG0596	Alpha beta hydrolase
AL537_RS09375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL537_RS09395	COG2855	membrane
AL537_RS09400	COG0477	Major facilitator Superfamily
AL537_RS09445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_RS09450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_RS09475	COG1522	sequence-specific DNA binding
AL537_RS09485	COG1946	Acyl-CoA thioesterase
AL537_RS09490	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL537_RS09515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL537_RS09520	COG0516	GMP reductase activity
AL537_RS09520	COG0517	IMP dehydrogenase activity
AL537_RS09545	COG0537	adenosine 5'-monophosphoramidase activity
AL537_RS09570	COG3150	esterase
AL537_RS09575	COG1252	NADH dehydrogenase
AL537_RS09590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL537_RS09600	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL537_RS09605	COG1136	(ABC) transporter
AL537_RS09610	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL537_RS09620	COG0658	competence protein
AL537_RS09620	COG2333	competence protein COMEC
AL537_RS09625	COG1132	(ABC) transporter
AL537_RS09645	COG2719	SpoVR family
AL537_RS09650	COG2718	Belongs to the UPF0229 family
AL537_RS09655	COG2766	serine protein kinase
AL537_RS09665	COG3013	Belongs to the UPF0304 family
AL537_RS09675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL537_RS09685	COG1882	Formate acetyltransferase
AL537_RS09730	COG0708	Exodeoxyribonuclease III
AL537_RS09740	COG3923	Primosomal replication protein n
AL537_RS09745	COG0730	response to heat
AL537_RS09750	COG1199	ATP-dependent helicase activity
AL537_RS09755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_RS09760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL537_RS09765	COG1187	pseudouridine synthase activity
AL537_RS09775	COG1278	Cold shock
AL537_RS09780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL537_RS09785	COG0542	response to heat
AL537_RS09790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL537_RS09795	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL537_RS09800	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL537_RS09820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL537_RS09825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL537_RS09830	COG0297	glycogen (starch) synthase activity
AL537_RS09850	COG3070	regulator of competence-specific genes
AL537_RS09855	COG1609	Transcriptional regulator
AL537_RS09860	COG3381	protein complex oligomerization
AL537_RS09865	COG0745	RESPONSE REGULATOR receiver
AL537_RS09870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL537_RS09875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_RS09880	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL537_RS09885	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL537_RS09890	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL537_RS09910	COG4067	protein conserved in archaea
AL537_RS09910	COG0189	ligase activity
AL537_RS09920	COG0500	methyltransferase
AL537_RS09930	COG1801	Protein of unknown function DUF72
AL537_RS09940	COG0217	transcriptional regulatory protein
AL537_RS09945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL537_RS09950	COG0632	four-way junction helicase activity
AL537_RS09955	COG2255	four-way junction helicase activity
AL537_RS09960	COG1271	oxidase subunit
AL537_RS09965	COG1294	oxidase, subunit
AL537_RS09970	COG4890	Cyd operon protein YbgT
AL537_RS09980	COG0824	Thioesterase
AL537_RS09985	COG0811	peptide transport
AL537_RS10000	COG0823	Involved in the tonB-independent uptake of proteins
AL537_RS10005	COG2885	chlorophyll binding
AL537_RS10010	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL537_RS10015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL537_RS10025	COG3766	membrane
AL537_RS10035	COG0754	glutathionylspermidine amidase activity
AL537_RS10045	COG0784	Response regulator, receiver
AL537_RS10045	COG5002	protein histidine kinase activity
AL537_RS10060	COG0840	transmembrane signaling receptor activity
AL537_RS10065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_RS10070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_RS10095	COG3568	Endonuclease Exonuclease Phosphatase
AL537_RS10105	COG0840	transmembrane signaling receptor activity
AL537_RS10120	COG0583	DNA-binding transcription factor activity
AL537_RS10130	COG0686	Belongs to the AlaDH PNT family
AL537_RS10140	COG1674	ftsk spoiiie
AL537_RS10145	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL537_RS10150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL537_RS10155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL537_RS10170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL537_RS10195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL537_RS10215	COG0300	oxidoreductase activity
AL537_RS10230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL537_RS10240	COG2268	Band 7 protein
AL537_RS10250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL537_RS10255	COG2915	High frequency lysogenization protein hflD homolog
AL537_RS10260	COG0482	sulfurtransferase activity
AL537_RS10270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_RS10280	COG1757	Na H antiporter
AL537_RS10290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL537_RS10295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL537_RS10300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL537_RS10305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL537_RS10305	COG0131	Imidazoleglycerol-phosphate dehydratase
AL537_RS10310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL537_RS10315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL537_RS10325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL537_RS10325	COG0140	phosphoribosyl-ATP diphosphatase activity
AL537_RS10330	COG3012	SEC-C Motif Domain Protein
AL537_RS10335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL537_RS10340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL537_RS10345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL537_RS10350	COG0215	cysteine-tRNA ligase activity
AL537_RS10355	COG1435	thymidine kinase activity
AL537_RS10360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL537_RS10385	COG2116	formate transmembrane transporter activity
AL537_RS10395	COG0390	transport system, permease component
AL537_RS10400	COG4459	periplasmic nitrate reductase
AL537_RS10405	COG3005	denitrification pathway
AL537_RS10410	COG0243	molybdopterin cofactor binding
AL537_RS10425	COG1227	inorganic diphosphatase activity
AL537_RS10435	COG4172	Belongs to the ABC transporter superfamily
AL537_RS10445	COG4171	peptide transport system, permease
AL537_RS10460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL537_RS10465	COG1842	Phage shock protein A
AL537_RS10475	COG1983	PspC domain protein
AL537_RS10495	COG2818	Glycosylase
AL537_RS10500	COG5380	lipid catabolic process
AL537_RS10505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL537_RS10510	COG0626	cystathionine gamma-synthase activity
AL537_RS10520	COG0733	neurotransmitter:sodium symporter activity
AL537_RS10525	COG0564	pseudouridine synthase activity
AL537_RS10535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL537_RS10540	COG1151	hydroxylamine reductase activity
AL537_RS10545	COG3604	Transcriptional regulator
AL537_RS10560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL537_RS10565	COG4136	ATPase activity
AL537_RS10570	COG4135	transport system, permease component
AL537_RS10575	COG4134	Bacterial extracellular solute-binding protein
AL537_RS10585	COG3313	Fe-S protein
AL537_RS10605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL537_RS10625	COG1061	Type III restriction enzyme res subunit
AL537_RS10630	COG1187	pseudouridine synthase activity
AL537_RS10640	COG2814	Major facilitator Superfamily
AL537_RS10670	COG3005	denitrification pathway
AL537_RS10675	COG0702	epimerase
AL537_RS10680	COG0534	Mate efflux family protein
AL537_RS10700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL537_RS10710	COG1960	acyl-CoA dehydrogenase activity
AL537_RS10715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL537_RS10720	COG2985	domain, Protein
AL537_RS10720	COG3273	potassium ion transport
AL537_RS10725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL537_RS10735	COG1737	Transcriptional regulator
AL537_RS10740	COG0076	glutamate decarboxylase activity
AL537_RS10750	COG2431	L-lysine efflux transmembrane transporter activity
AL537_RS10765	COG3070	regulator of competence-specific genes
AL537_RS10780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_RS10780	COG4191	Histidine kinase
AL537_RS10790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL537_RS10800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL537_RS10805	COG4988	ABC transporter
AL537_RS10810	COG0492	ferredoxin-NADP+ reductase activity
AL537_RS10835	COG0471	metal ion transport
AL537_RS10840	COG2949	membrane
AL537_RS10845	COG0281	malic enzyme
AL537_RS10850	COG1643	Atp-dependent helicase
AL537_RS10865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL537_RS10900	COG0247	lactate metabolic process
AL537_RS10900	COG0277	FAD linked oxidase domain protein
AL537_RS10915	COG2986	histidine ammonia-lyase
AL537_RS10920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL537_RS10925	COG0010	Belongs to the arginase family
AL537_RS10930	COG1228	amidohydrolase
AL537_RS10935	COG2188	Transcriptional regulator
AL537_RS10950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL537_RS10960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL537_RS10970	COG0393	Putative heavy-metal-binding
AL537_RS11000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL537_RS11005	COG0072	phenylalanine-tRNA ligase activity
AL537_RS11005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_RS11015	COG0776	regulation of translation
AL537_RS11025	COG0500	methyltransferase
AL537_RS11030	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL537_RS11035	COG0295	cytidine deaminase activity
AL537_RS11040	COG1346	cytolysis
AL537_RS11045	COG1380	Effector of murein hydrolase LrgA
AL537_RS11050	COG2925	Exonuclease
AL537_RS11090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL537_RS11115	COG1484	DNA-dependent DNA replication
AL537_RS11260	COG1823	symporter activity
AL537_RS11265	COG0702	epimerase
AL537_RS11270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL537_RS11275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL537_RS11295	COG2988	succinylglutamate desuccinylase activity
AL537_RS11300	COG4139	cobalamin transport
AL537_RS11305	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL537_RS11325	COG0583	DNA-binding transcription factor activity
AL537_RS11335	COG1451	nucleotide metabolic process
AL537_RS11340	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AL537_RS11370	COG3938	Belongs to the proline racemase family
AL537_RS11385	COG2423	ornithine cyclodeaminase activity
AL537_RS11390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL537_RS11395	COG3842	ATPase activity
AL537_RS11400	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL537_RS11405	COG1177	transmembrane transport
AL537_RS11420	COG3291	Pkd domain containing protein
AL537_RS11435	COG0444	Belongs to the ABC transporter superfamily
AL537_RS11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_RS11445	COG0601	transmembrane transport
AL537_RS11455	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL537_RS11465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL537_RS11475	COG0625	glutathione transferase activity
AL537_RS11510	COG2200	EAL domain
AL537_RS11510	COG2771	luxR family
AL537_RS11520	COG1846	Transcriptional regulator
AL537_RS11525	COG2315	Protein conserved in bacteria
AL537_RS11540	COG0110	maltose O-acetyltransferase activity
AL537_RS11570	COG3063	Type IV pilus biogenesis stability protein PilW
AL537_RS11575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL537_RS11590	COG0531	amino acid
AL537_RS11595	COG1560	Kdo2-lipid A biosynthetic process
AL537_RS11600	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL537_RS11605	COG1280	lysine exporter protein (LysE YggA)
AL537_RS11615	COG1115	amino acid carrier protein
AL537_RS11640	COG1368	sulfuric ester hydrolase activity
AL537_RS11645	COG0642	Histidine kinase
AL537_RS11650	COG0745	RESPONSE REGULATOR receiver
AL537_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS11670	COG1022	Amp-dependent synthetase and ligase
AL537_RS11680	COG2113	Glycine betaine
AL537_RS11685	COG4176	ABC-type proline glycine betaine transport system permease component
AL537_RS11705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_RS11710	COG0456	acetyltransferase
AL537_RS11715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL537_RS11720	COG0662	Cupin 2, conserved barrel domain protein
AL537_RS11725	COG0527	aspartate kinase activity
AL537_RS11730	COG3119	arylsulfatase activity
AL537_RS11745	COG0641	radical SAM
AL537_RS11760	COG1349	DNA-binding transcription factor activity
AL537_RS11765	COG0673	inositol 2-dehydrogenase activity
AL537_RS11770	COG4702	Belongs to the UPF0303 family
AL537_RS11795	COG0471	metal ion transport
AL537_RS11800	COG4191	Histidine kinase
AL537_RS11810	COG5001	Diguanylate cyclase
AL537_RS11810	COG3300	MHYT domain
AL537_RS11825	COG1328	CTP reductase activity
AL537_RS11830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL537_RS11840	COG0861	Integral membrane protein TerC family
AL537_RS11850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL537_RS11860	COG0814	amino acid
AL537_RS11875	COG1120	ATPase activity
AL537_RS11880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL537_RS11890	COG4774	siderophore transport
AL537_RS11900	COG1132	(ABC) transporter
AL537_RS11905	COG1132	(ABC) transporter
AL537_RS11910	COG2165	general secretion pathway protein
AL537_RS11930	COG0443	Heat shock 70 kDa protein
AL537_RS11935	COG0443	Heat shock 70 kDa protein
AL537_RS11980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL537_RS11985	COG1643	Atp-dependent helicase
AL537_RS12000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_RS12010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL537_RS12015	COG1215	transferase activity, transferring glycosyl groups
AL537_RS12020	COG0438	transferase activity, transferring glycosyl groups
AL537_RS12050	COG0438	transferase activity, transferring glycosyl groups
AL537_RS12060	COG2204	response regulator
AL537_RS12090	COG1793	dna ligase
AL537_RS12100	COG0534	Mate efflux family protein
AL537_RS12105	COG0307	riboflavin synthase, alpha
AL537_RS12115	COG3001	Fructosamine kinase
AL537_RS12125	COG3706	GGDEF domain
AL537_RS12135	COG0791	NLP P60 protein
AL537_RS12170	COG3148	PFAM DTW domain containing protein
AL537_RS12175	COG1940	carbohydrate kinase activity
AL537_RS12185	COG0303	'Molybdopterin
AL537_RS12190	COG0746	molybdenum cofactor guanylyltransferase activity
AL537_RS12195	COG3842	ATPase activity
AL537_RS12210	COG2204	response regulator
AL537_RS12215	COG4191	Histidine kinase
AL537_RS12225	COG0488	(ABC) transporter
AL537_RS12230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL537_RS12250	COG3381	protein complex oligomerization
AL537_RS12260	COG0243	molybdopterin cofactor binding
AL537_RS12260	COG3383	formate dehydrogenase (NAD+) activity
AL537_RS12265	COG0437	4 iron, 4 sulfur cluster binding
AL537_RS12290	COG0004	ammonium transporteR
AL537_RS12295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL537_RS12300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL537_RS12310	COG1177	transmembrane transport
AL537_RS12320	COG3842	ATPase activity
AL537_RS12345	COG0589	response to stress
AL537_RS12350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_RS12365	COG2217	Heavy metal translocating P-type atpase
AL537_RS12375	COG2010	Cytochrome c
AL537_RS12390	COG3278	Belongs to the heme-copper respiratory oxidase family
AL537_RS12405	COG0784	Response regulator, receiver
AL537_RS12405	COG2205	protein histidine kinase activity
AL537_RS12615	COG3120	sequence-specific DNA binding
AL537_RS12620	COG1067	ATP-dependent peptidase activity
AL537_RS12625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL537_RS12640	COG0488	(ABC) transporter
AL537_RS12650	COG0116	Belongs to the methyltransferase superfamily
AL537_RS12650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL537_RS12660	COG0167	dihydroorotate dehydrogenase activity
AL537_RS12665	COG2902	Dehydrogenase
AL537_RS12675	COG0308	aminopeptidase N
AL537_RS12690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AL537_RS12810	COG4695	Portal protein
AL537_RS12890	COG1428	Deoxynucleoside kinase
AL537_RS12940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_RS12940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL537_RS12985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AL537_RS12990	COG0308	aminopeptidase N
AL537_RS13005	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL537_RS13010	COG1956	GAF domain-containing protein
AL537_RS13015	COG1132	(ABC) transporter
AL537_RS13020	COG2995	paraquat-inducible protein a
AL537_RS13025	COG3008	intermembrane lipid transfer
AL537_RS13050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL537_RS13055	COG1666	GTP binding
AL537_RS13070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_RS13075	COG4597	amino acid ABC transporter
AL537_RS13080	COG0765	amino acid transport
AL537_RS13085	COG1126	abc transporter atp-binding protein
AL537_RS13090	COG0670	Belongs to the BI1 family
AL537_RS13100	COG2920	part of a sulfur-relay system
AL537_RS13105	COG1254	Belongs to the acylphosphatase family
AL537_RS13155	COG3706	GGDEF domain
AL537_RS13160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL537_RS13165	COG0602	queuosine metabolic process
AL537_RS13170	COG0561	phosphatase activity
AL537_RS13195	COG2828	Protein conserved in bacteria
AL537_RS13205	COG0372	Belongs to the citrate synthase family
AL537_RS13210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL537_RS13245	COG0730	response to heat
AL537_RS13250	COG2358	TRAP transporter, solute receptor (TAXI family
AL537_RS13265	COG0457	Tetratricopeptide repeat
AL537_RS13335	COG4790	Type iii secretion
AL537_RS13340	COG4794	Type iii secretion
AL537_RS13345	COG4791	protein targeting
AL537_RS13350	COG4792	protein secretion
AL537_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS13405	COG3177	Filamentation induced by cAMP protein fic
AL537_RS13425	COG4669	(LipO)protein
AL537_RS13495	COG1012	belongs to the aldehyde dehydrogenase family
AL537_RS13500	COG3284	Transcriptional regulator
AL537_RS13525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL537_RS13530	COG0363	glucosamine-6-phosphate deaminase activity
AL537_RS13535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL537_RS13550	COG4565	transcriptional regulatory protein
AL537_RS13555	COG3290	protein histidine kinase activity
AL537_RS13570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_RS13585	COG0583	DNA-binding transcription factor activity
AL537_RS13600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL537_RS13610	COG2985	domain, Protein
AL537_RS13640	COG2272	Belongs to the type-B carboxylesterase lipase family
AL537_RS13645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL537_RS13650	COG0729	surface antigen
AL537_RS13660	COG1280	lysine exporter protein (LysE YggA)
AL537_RS13670	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL537_RS13690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL537_RS13770	COG2200	EAL domain
AL537_RS13790	COG0697	spore germination
AL537_RS13815	COG3459	Glycosyltransferase 36 associated
AL537_RS13830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL537_RS13995	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL537_RS14045	COG2226	methyltransferase
AL537_RS14280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_RS14290	COG3768	UPF0283 membrane protein
AL537_RS14295	COG3106	COG3106 Predicted ATPase
AL537_RS14315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL537_RS14320	COG2205	protein histidine kinase activity
AL537_RS14320	COG0784	Response regulator, receiver
AL537_RS14330	COG0494	nUDIX hydrolase
AL537_RS14335	COG0814	amino acid
AL537_RS14340	COG1760	l-serine dehydratase
AL537_RS14345	COG2200	EAL domain
AL537_RS14355	COG0720	synthase
AL537_RS14360	COG3646	Phage regulatory protein
AL537_RS14380	COG3646	Phage regulatory protein
AL537_RS14590	COG0751	glycine-tRNA ligase activity
AL537_RS14625	COG5532	Uncharacterized conserved protein (DUF2303)
AL537_RS14650	COG1278	Cold shock
AL537_RS14655	COG0582	viral genome integration into host DNA
AL537_RS14675	COG3300	MHYT domain
AL537_RS14675	COG5001	Diguanylate cyclase
AL537_RS14680	COG0840	transmembrane signaling receptor activity
AL537_RS14685	COG0017	Asparaginyl-tRNA synthetase
AL537_RS14695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_RS14710	COG1448	Aminotransferase
AL537_RS14730	COG0840	transmembrane signaling receptor activity
AL537_RS14735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_RS14765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL537_RS14780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL537_RS14785	COG3108	Peptidase M15
AL537_RS14790	COG2989	Protein conserved in bacteria
AL537_RS14815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL537_RS14825	COG4235	cytochrome complex assembly
AL537_RS14825	COG3088	subunit of a heme lyase
AL537_RS14835	COG1138	Cytochrome C-type biogenesis protein
AL537_RS14840	COG3301	Polysulphide reductase, NrfD
AL537_RS14845	COG0437	4 iron, 4 sulfur cluster binding
AL537_RS14855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL537_RS14875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_RS14880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL537_RS14910	COG0019	diaminopimelate decarboxylase activity
AL537_RS14950	COG0322	excinuclease ABC activity
AL537_RS14955	COG2197	response regulator
AL537_RS14960	COG0417	DNA replication proofreading
AL537_RS14980	COG1187	pseudouridine synthase activity
AL537_RS14990	COG0009	L-threonylcarbamoyladenylate synthase
AL537_RS14995	COG0613	PHP domain protein
AL537_RS15005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL537_RS15010	COG0512	Glutamine amidotransferase of anthranilate synthase
AL537_RS15020	COG0134	indole-3-glycerol-phosphate synthase activity
AL537_RS15020	COG0135	phosphoribosylanthranilate isomerase activity
AL537_RS15030	COG0159	tryptophan synthase activity
AL537_RS15035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_RS15040	COG0318	PFAM AMP-dependent synthetase and ligase
AL537_RS15050	COG1301	dicarboxylic acid transport
AL537_RS15070	COG2917	probably involved in intracellular septation
AL537_RS15085	COG2350	Protein conserved in bacteria
AL537_RS15095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL537_RS15100	COG0583	DNA-binding transcription factor activity
AL537_RS15115	COG5001	Diguanylate cyclase
AL537_RS15120	COG1032	radical SAM domain protein
AL537_RS15135	COG0840	transmembrane signaling receptor activity
AL537_RS15145	COG0745	RESPONSE REGULATOR receiver
AL537_RS15150	COG5002	protein histidine kinase activity
AL537_RS15150	COG3850	Histidine kinase
AL537_RS15200	COG1335	isochorismatase
AL537_RS15205	COG0577	efflux transmembrane transporter activity
AL537_RS15205	COG1136	(ABC) transporter
AL537_RS15215	COG1136	(ABC) transporter
AL537_RS15215	COG0577	efflux transmembrane transporter activity
AL537_RS15225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_RS15255	COG3118	belongs to the thioredoxin family
AL537_RS15260	COG4232	protein-disulfide reductase activity
AL537_RS15295	COG2863	cytochrome
AL537_RS15300	COG3258	Cytochrome c
AL537_RS15305	COG2995	paraquat-inducible protein a
AL537_RS15310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL537_RS15310	COG3008	intermembrane lipid transfer
AL537_RS15325	COG4166	transmembrane transport
AL537_RS15335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL537_RS15340	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL537_RS15350	COG0539	negative regulation of cytoplasmic translation
AL537_RS15355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL537_RS15360	COG0616	signal peptide processing
AL537_RS15365	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS15380	COG0587	DNA-directed DNA polymerase activity
AL537_RS15385	COG0835	chemotaxis
AL537_RS15385	COG0784	Response regulator, receiver
AL537_RS15390	COG1940	carbohydrate kinase activity
AL537_RS15395	COG0469	pyruvate kinase activity
AL537_RS15400	COG4667	esterase of the alpha-beta hydrolase superfamily
AL537_RS15415	COG0733	neurotransmitter:sodium symporter activity
AL537_RS15430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_RS15430	COG1263	PTS System
AL537_RS15435	COG0084	hydrolase, TatD family'
AL537_RS15440	COG0470	DNA polymerase III
AL537_RS15445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL537_RS15450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL537_RS15480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL537_RS15485	COG0416	fatty acid biosynthetic process
AL537_RS15495	COG1399	metal-binding, possibly nucleic acid-binding protein
AL537_RS15500	COG0424	maF-like protein
AL537_RS15505	COG0564	pseudouridine synthase activity
AL537_RS15510	COG1530	ribonuclease E activity
AL537_RS15520	COG0659	secondary active sulfate transmembrane transporter activity
AL537_RS15525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL537_RS15530	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL537_RS15550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_RS15550	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL537_RS15560	COG2186	Transcriptional regulator
AL537_RS15565	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL537_RS15570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL537_RS15575	COG0653	protein targeting
AL537_RS15580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL537_RS15585	COG3706	GGDEF domain
AL537_RS15590	COG0366	Alpha amylase catalytic
AL537_RS15595	COG1122	ATPase activity
AL537_RS15600	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL537_RS15610	COG3092	negative regulation of chromosome organization
AL537_RS15615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL537_RS15620	COG0280	phosphate acetyltransferase
AL537_RS15620	COG0857	belongs to the CobB CobQ family
AL537_RS15625	COG3174	membrane
AL537_RS15635	COG0435	Glutathione S-transferase
AL537_RS15645	COG0444	Belongs to the ABC transporter superfamily
AL537_RS15650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_RS15655	COG0601	transmembrane transport
AL537_RS15665	COG0314	molybdopterin synthase activity
AL537_RS15670	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL537_RS15675	COG0315	cyclic pyranopterin monophosphate synthase activity
AL537_RS15680	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL537_RS15685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL537_RS15690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL537_RS15695	COG2198	Histidine kinase
AL537_RS15700	COG2204	response regulator
AL537_RS15705	COG0556	nucleotide-excision repair
AL537_RS15720	COG4657	Part of a membrane complex involved in electron transport
AL537_RS15725	COG2878	Part of a membrane complex involved in electron transport
AL537_RS15730	COG4656	Part of a membrane complex involved in electron transport
AL537_RS15735	COG4658	electron transport chain
AL537_RS15740	COG4659	FMN binding
AL537_RS15745	COG4660	Part of a membrane complex involved in electron transport
AL537_RS15750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL537_RS15755	COG0346	lactoylglutathione lyase activity
AL537_RS15765	COG2885	chlorophyll binding
AL537_RS15775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL537_RS15780	COG2056	Na+-H+ antiporter family
AL537_RS15910	COG4695	Portal protein
AL537_RS16015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL537_RS16020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL537_RS16040	COG1012	belongs to the aldehyde dehydrogenase family
AL537_RS16040	COG1454	alcohol dehydrogenase
AL537_RS16045	COG2095	MarC family integral membrane protein
AL537_RS16050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL537_RS16055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL537_RS16060	COG1757	Na H antiporter
AL537_RS16075	COG3081	Nucleoid-associated protein
AL537_RS16080	COG3082	Protein of unknown function (DUF1414)
AL537_RS16095	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL537_RS16110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL537_RS16115	COG0778	Nitroreductase
AL537_RS16125	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL537_RS16125	COG1902	pentaerythritol trinitrate reductase activity
AL537_RS16130	COG0616	signal peptide processing
AL537_RS16135	COG0252	asparaginase activity
AL537_RS16140	COG3139	Protein of unknown function (DUF1315)
AL537_RS16150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_RS16155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL537_RS16170	COG2226	methyltransferase
AL537_RS16190	COG1785	Belongs to the alkaline phosphatase family
AL537_RS16200	COG0346	lactoylglutathione lyase activity
AL537_RS16205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL537_RS16210	COG0668	transmembrane transport
AL537_RS16215	COG2983	Belongs to the UPF0260 family
AL537_RS16220	COG2261	transglycosylase associated protein
AL537_RS16235	COG3681	Belongs to the UPF0597 family
AL537_RS16240	COG0251	oxidation-reduction process
AL537_RS16245	COG0814	amino acid
AL537_RS16250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL537_RS16255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL537_RS16270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL537_RS16275	COG2832	Protein of unknown function (DUF454)
AL537_RS16285	COG0745	RESPONSE REGULATOR receiver
AL537_RS16290	COG0583	DNA-binding transcription factor activity
AL537_RS16295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL537_RS16300	COG1286	toxin biosynthetic process
AL537_RS16305	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL537_RS16310	COG0285	dihydrofolate synthase activity
AL537_RS16315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL537_RS16325	COG0101	tRNA pseudouridine synthase activity
AL537_RS16335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL537_RS16340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL537_RS16350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL537_RS16355	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL537_RS16355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL537_RS16360	COG0431	NADPH-dependent FMN reductase
AL537_RS16375	COG3101	peptidyl-lysine hydroxylation
AL537_RS16385	COG2860	membrane
AL537_RS16390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL537_RS16395	COG2890	protein-(glutamine-N5) methyltransferase activity
AL537_RS16400	COG2840	Smr protein MutS2
AL537_RS16405	COG2062	phosphohistidine phosphatase, SixA
AL537_RS16420	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL537_RS16420	COG1024	Enoyl-CoA hydratase
AL537_RS16425	COG0183	Belongs to the thiolase family
AL537_RS16455	COG3088	subunit of a heme lyase
AL537_RS16455	COG4235	cytochrome complex assembly
AL537_RS16465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL537_RS16470	COG1138	Cytochrome C-type biogenesis protein
AL537_RS16475	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL537_RS16480	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL537_RS16485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL537_RS16490	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL537_RS16495	COG4133	protoheme IX ABC transporter activity
AL537_RS16505	COG0835	chemotaxis
AL537_RS16515	COG1192	Involved in chromosome partitioning
AL537_RS16520	COG2201	protein-glutamate methylesterase activity
AL537_RS16525	COG0643	Histidine kinase
AL537_RS16525	COG2198	Histidine kinase
AL537_RS16525	COG0784	Response regulator, receiver
AL537_RS16530	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL537_RS16565	COG1684	flagellar biosynthetic protein fliR
AL537_RS16570	COG1987	bacterial-type flagellum assembly
AL537_RS16645	COG0826	peptidase U32
AL537_RS16650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_RS16660	COG0463	Glycosyl transferase, family 2
AL537_RS16680	COG1136	(ABC) transporter
AL537_RS16685	COG0577	efflux transmembrane transporter activity
AL537_RS16700	COG1764	response to oxidative stress
AL537_RS16705	COG1846	Transcriptional regulator
AL537_RS16715	COG3634	alkyl hydroperoxide reductase activity
AL537_RS16745	COG1595	DNA-templated transcription, initiation
AL537_RS16765	COG2258	MOSC domain
AL537_RS16790	COG2207	Transcriptional regulator
AL537_RS16800	COG1132	(ABC) transporter
AL537_RS16835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL537_RS16860	COG0259	pyridoxamine-phosphate oxidase activity
AL537_RS16915	COG4166	transmembrane transport
AL537_RS16935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL537_RS16940	COG1263	PTS System
AL537_RS16940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_RS16945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_RS16950	COG3340	Belongs to the peptidase S51 family
AL537_RS16970	COG1444	tRNA N-acetyltransferase activity
AL537_RS16995	COG4608	Belongs to the ABC transporter superfamily
AL537_RS17000	COG0444	Belongs to the ABC transporter superfamily
AL537_RS17010	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AL537_RS17010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL537_RS17035	COG0772	Belongs to the SEDS family
AL537_RS17045	COG1136	(ABC) transporter
AL537_RS17065	COG3275	phosphorelay sensor kinase activity
AL537_RS17070	COG3279	Response regulator of the LytR AlgR family
AL537_RS17080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL537_RS17100	COG0786	glutamate:sodium symporter activity
AL537_RS17110	COG1131	(ABC) transporter
AL537_RS17115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_RS17120	COG0786	glutamate:sodium symporter activity
AL537_RS17130	COG0363	glucosamine-6-phosphate deaminase activity
AL537_RS17150	COG1741	Belongs to the pirin family
AL537_RS17155	COG2259	Doxx family
AL537_RS17165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL537_RS17170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL537_RS17180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL537_RS17205	COG0596	Alpha beta hydrolase
AL537_RS17220	COG3123	guanosine phosphorylase activity
AL537_RS17230	COG5001	Diguanylate cyclase
AL537_RS17235	COG0534	Mate efflux family protein
AL537_RS17240	COG0564	pseudouridine synthase activity
AL537_RS17255	COG0583	DNA-binding transcription factor activity
AL537_RS17260	COG0561	phosphatase activity
AL537_RS17270	COG2199	diguanylate cyclase activity
AL537_RS17285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL537_RS17290	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL537_RS17295	COG0583	DNA-binding transcription factor activity
AL537_RS17300	COG2375	cellular response to nickel ion
AL537_RS17335	COG1357	PFAM Pentapeptide repeats (8 copies)
AL537_RS17340	COG3047	cAMP biosynthetic process
AL537_RS17370	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AL537_RS17370	COG3408	Glycogen debranching enzyme
AL537_RS17375	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AL537_RS17395	COG0583	DNA-binding transcription factor activity
AL537_RS17410	COG0546	phosphoglycolate phosphatase activity
AL537_RS17435	COG3835	regulator
AL537_RS17440	COG2610	gluconate transmembrane transporter activity
AL537_RS17445	COG1929	Belongs to the glycerate kinase type-1 family
AL537_RS17450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_RS17470	COG0456	acetyltransferase
AL537_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS17490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_RS17495	COG3005	denitrification pathway
AL537_RS17500	COG0243	molybdopterin cofactor binding
AL537_RS17510	COG0352	thiamine-phosphate diphosphorylase activity
AL537_RS17515	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL537_RS17520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL537_RS17525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL537_RS17530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL537_RS17535	COG1116	anion transmembrane transporter activity
AL537_RS17540	COG0351	phosphomethylpyrimidine kinase
AL537_RS17545	COG0312	modulator of DNA gyrase
AL537_RS17550	COG0312	modulator of DNA gyrase
AL537_RS17555	COG1901	pseudouridine methyltransferase
AL537_RS17620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL537_RS17630	COG0584	glycerophosphoryl diester phosphodiesterase
AL537_RS17635	COG0039	L-malate dehydrogenase activity
AL537_RS17640	COG0745	RESPONSE REGULATOR receiver
AL537_RS17660	COG0811	peptide transport
AL537_RS17665	COG0811	peptide transport
AL537_RS17670	COG0848	biopolymer transport protein
AL537_RS17710	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL537_RS17715	COG1121	(ABC) transporter
AL537_RS17720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL537_RS17735	COG1770	oligopeptidase
AL537_RS17740	COG2814	Major facilitator Superfamily
AL537_RS17745	COG0010	Belongs to the arginase family
AL537_RS17750	COG1166	arginine decarboxylase activity
AL537_RS17760	COG0189	ligase activity
AL537_RS17760	COG4067	protein conserved in archaea
AL537_RS17765	COG0189	ligase activity
AL537_RS17770	COG0583	DNA-binding transcription factor activity
AL537_RS17805	COG4191	Histidine kinase
AL537_RS17810	COG2204	response regulator
AL537_RS17815	COG3706	GGDEF domain
AL537_RS17840	COG0579	oxidoreductase
AL537_RS17855	COG1294	oxidase, subunit
AL537_RS17860	COG1271	oxidase subunit
AL537_RS17870	COG3033	Beta-eliminating lyase
AL537_RS17890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL537_RS17905	COG3706	GGDEF domain
AL537_RS17925	COG3706	GGDEF domain
AL537_RS17930	COG0415	Belongs to the DNA photolyase family
AL537_RS17935	COG3046	protein related to deoxyribodipyrimidine photolyase
AL537_RS17950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_RS17950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_RS17955	COG1765	OsmC-like protein
AL537_RS17960	COG0110	maltose O-acetyltransferase activity
AL537_RS18000	COG1011	Hydrolase
AL537_RS18015	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL537_RS18025	COG2067	long-chain fatty acid transport protein
AL537_RS18030	COG3240	lipase activity
AL537_RS18060	COG1609	Transcriptional regulator
AL537_RS18065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_RS18070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL537_RS18080	COG1840	ABC-type Fe3 transport system, periplasmic component
AL537_RS18085	COG3842	ATPase activity
AL537_RS18110	COG2990	Protein conserved in bacteria
AL537_RS18120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL537_RS18125	COG2866	Carboxypeptidase
AL537_RS18135	COG0583	DNA-binding transcription factor activity
AL537_RS18155	COG3104	oligopeptide transport
AL537_RS18160	COG1760	l-serine dehydratase
AL537_RS18180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL537_RS18185	COG0741	lytic transglycosylase activity
AL537_RS18205	COG1815	bacterial-type flagellum-dependent cell motility
AL537_RS18210	COG1558	bacterial-type flagellum-dependent cell motility
AL537_RS18215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL537_RS18220	COG1749	Flagellar hook protein flgE
AL537_RS18225	COG4787	bacterial-type flagellum-dependent cell motility
AL537_RS18230	COG4786	Flagellar basal body rod
AL537_RS18235	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL537_RS18240	COG1706	bacterial-type flagellum-dependent cell motility
AL537_RS18250	COG4786	Flagellar basal body rod
AL537_RS18250	COG1256	bacterial-type flagellum assembly
AL537_RS18255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS18275	COG1304	FMN binding
AL537_RS18290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL537_RS18295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL537_RS18300	COG0459	protein refolding
AL537_RS18330	COG1309	transcriptional regulator
AL537_RS18340	COG4303	Ethanolamine ammonia lyase large subunit
AL537_RS18345	COG4302	ethanolamine ammonia-lyase activity
AL537_RS18350	COG0531	amino acid
AL537_RS18355	COG2070	2-Nitropropane dioxygenase
AL537_RS18360	COG3537	Alpha-1,2-mannosidase
AL537_RS18365	COG3537	Alpha-1,2-mannosidase
AL537_RS18375	COG3537	Alpha-1,2-mannosidase
AL537_RS18380	COG3537	Alpha-1,2-mannosidase
AL537_RS18385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_RS18395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_RS18395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL537_RS18400	COG0346	lactoylglutathione lyase activity
AL537_RS18405	COG1349	DNA-binding transcription factor activity
AL537_RS18415	COG1335	isochorismatase
AL537_RS18425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL537_RS18450	COG0583	DNA-binding transcription factor activity
AL537_RS18465	COG3713	MltA-interacting MipA family protein
AL537_RS18470	COG3015	lipoprotein NlpE involved in copper resistance
AL537_RS18475	COG3448	diguanylate cyclase activity
AL537_RS18475	COG4175	Glycine betaine
AL537_RS18480	COG4176	ABC-type proline glycine betaine transport system permease component
AL537_RS18490	COG1342	Belongs to the UPF0251 family
AL537_RS18525	COG4948	Mandelate Racemase Muconate Lactonizing
AL537_RS18535	COG0583	DNA-binding transcription factor activity
AL537_RS18575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL537_RS18605	COG3842	ATPase activity
AL537_RS18635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_RS18655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL537_RS18660	COG2197	response regulator
AL537_RS18675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL537_RS18680	COG0252	asparaginase activity
AL537_RS18685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL537_RS18690	COG0583	DNA-binding transcription factor activity
AL537_RS18700	COG1280	lysine exporter protein (LysE YggA)
AL537_RS18705	COG3122	Protein conserved in bacteria
AL537_RS18715	COG2423	ornithine cyclodeaminase activity
AL537_RS18720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL537_RS18725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL537_RS18730	COG1012	belongs to the aldehyde dehydrogenase family
AL537_RS18735	COG1522	sequence-specific DNA binding
AL537_RS18740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL537_RS18745	COG3608	succinylglutamate desuccinylase aspartoacylase
AL537_RS18750	COG0006	proline dipeptidase activity
AL537_RS18755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_RS18760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL537_RS18765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL537_RS18770	COG2207	Transcriptional regulator
AL537_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS18785	COG1063	alcohol dehydrogenase
AL537_RS18790	COG1902	pentaerythritol trinitrate reductase activity
AL537_RS18805	COG0583	DNA-binding transcription factor activity
AL537_RS18815	COG0513	Belongs to the DEAD box helicase family
AL537_RS18855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_RS18860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL537_RS18860	COG2207	Transcriptional regulator
AL537_RS18880	COG3746	phosphate-selective porin O and P
AL537_RS18895	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS18915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_RS18915	COG1263	PTS System
AL537_RS18920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_RS18925	COG1621	beta-fructofuranosidase activity
AL537_RS18935	COG0625	glutathione transferase activity
AL537_RS18950	COG1686	Belongs to the peptidase S11 family
AL537_RS18960	COG0678	peroxiredoxin activity
AL537_RS18960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL537_RS18965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL537_RS18980	COG1278	Cold shock
AL537_RS18985	COG1741	Belongs to the pirin family
AL537_RS18990	COG4667	esterase of the alpha-beta hydrolase superfamily
AL537_RS19010	COG2194	sulfuric ester hydrolase activity
AL537_RS19015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL537_RS19025	COG2205	protein histidine kinase activity
AL537_RS19030	COG0745	RESPONSE REGULATOR receiver
AL537_RS19045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL537_RS19065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL537_RS19075	COG2814	Major facilitator Superfamily
AL537_RS19090	COG1418	mRNA catabolic process
AL537_RS19095	COG0402	S-adenosylhomocysteine deaminase activity
AL537_RS19100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL537_RS19105	COG2239	Acts as a magnesium transporter
AL537_RS19110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL537_RS19115	COG1566	PFAM secretion protein HlyD family protein
AL537_RS19140	COG0745	RESPONSE REGULATOR receiver
AL537_RS19145	COG2205	protein histidine kinase activity
AL537_RS19160	COG0531	amino acid
AL537_RS19175	COG0583	DNA-binding transcription factor activity
AL537_RS19200	COG5002	protein histidine kinase activity
AL537_RS19200	COG2205	protein histidine kinase activity
AL537_RS19200	COG0784	Response regulator, receiver
AL537_RS19220	COG3132	Protein of unknown function, DUF480
AL537_RS19225	COG2827	Endonuclease containing a URI domain
AL537_RS19235	COG1879	ABC-type sugar transport system periplasmic component
AL537_RS19240	COG0784	Response regulator, receiver
AL537_RS19240	COG2205	protein histidine kinase activity
AL537_RS19300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_RS19305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL537_RS19315	COG1280	lysine exporter protein (LysE YggA)
AL537_RS19330	COG0183	Belongs to the thiolase family
AL537_RS19340	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL537_RS19350	COG3005	denitrification pathway
AL537_RS19360	COG0243	molybdopterin cofactor binding
AL537_RS19370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL537_RS19375	COG3850	Histidine kinase
AL537_RS19380	COG2197	response regulator
AL537_RS19395	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL537_RS19415	COG0840	transmembrane signaling receptor activity
AL537_RS19425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_RS19440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL537_RS19445	COG2814	Major facilitator Superfamily
AL537_RS19450	COG0840	transmembrane signaling receptor activity
AL537_RS19455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL537_RS19460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL537_RS19490	COG2897	thiosulfate sulfurtransferase activity
AL537_RS19510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL537_RS19525	COG1914	H( )-stimulated, divalent metal cation uptake system
AL537_RS19535	COG0038	chloride channel
AL537_RS19550	COG4989	oxidoreductase activity
AL537_RS19565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL537_RS19565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL537_RS19575	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL537_RS19620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_RS19635	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL537_RS19640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL537_RS19640	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL537_RS19650	COG0739	heme binding
AL537_RS19675	COG2204	response regulator
AL537_RS19690	COG3501	Rhs element vgr protein
AL537_RS19715	COG0515	serine threonine protein kinase
AL537_RS19750	COG1522	sequence-specific DNA binding
AL537_RS19865	COG2814	Major facilitator Superfamily
AL537_RS19875	COG0583	DNA-binding transcription factor activity
AL537_RS19880	COG4221	oxidoreductase activity
AL537_RS19885	COG0589	response to stress
AL537_RS19895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL537_RS19895	COG2111	Na H antiporter
AL537_RS19900	COG1006	Multisubunit Na H antiporter MnhC subunit
AL537_RS19905	COG0651	ATP synthesis coupled electron transport
AL537_RS19910	COG1863	multisubunit Na H antiporter MnhE subunit
AL537_RS19915	COG2212	antiporter activity
AL537_RS19920	COG1320	monovalent cation:proton antiporter activity
AL537_RS19925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL537_RS19990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_RS19995	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS20005	COG3527	Alpha-acetolactate decarboxylase
AL537_RS20015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_RS20030	COG1294	oxidase, subunit
AL537_RS20035	COG1271	oxidase subunit
AL537_RS20040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL537_RS20045	COG0110	maltose O-acetyltransferase activity
AL537_RS20060	COG4999	Histidine kinase
AL537_RS20060	COG3437	response regulator, receiver
AL537_RS20060	COG2205	protein histidine kinase activity
AL537_RS20060	COG3850	Histidine kinase
AL537_RS20070	COG4770	biotin carboxylase activity
AL537_RS20080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL537_RS20085	COG1960	acyl-CoA dehydrogenase activity
AL537_RS20095	COG0183	Belongs to the thiolase family
AL537_RS20105	COG1960	acyl-CoA dehydrogenase activity
AL537_RS20110	COG1024	Enoyl-CoA hydratase
AL537_RS20125	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS20135	COG1309	transcriptional regulator
AL537_RS20140	COG1012	belongs to the aldehyde dehydrogenase family
AL537_RS20155	COG4176	ABC-type proline glycine betaine transport system permease component
AL537_RS20160	COG0517	IMP dehydrogenase activity
AL537_RS20160	COG4175	Glycine betaine
AL537_RS20175	COG0330	HflC and HflK could
AL537_RS20185	COG5001	Diguanylate cyclase
AL537_RS20185	COG3300	MHYT domain
AL537_RS20195	COG2205	protein histidine kinase activity
AL537_RS20195	COG0784	Response regulator, receiver
AL537_RS20205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL537_RS20255	COG5001	Diguanylate cyclase
AL537_RS20260	COG1869	D-ribose catabolic process
AL537_RS20265	COG1129	ABC transporter
AL537_RS20270	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL537_RS20275	COG1879	ABC-type sugar transport system periplasmic component
AL537_RS20280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_RS20285	COG1609	Transcriptional regulator
AL537_RS20300	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL537_RS20310	COG4607	ABC-type enterochelin transport system periplasmic component
AL537_RS20315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_RS20320	COG4605	iron ion homeostasis
AL537_RS20325	COG4604	ABC transporter, ATP-binding protein
AL537_RS20330	COG0789	Transcriptional regulator
AL537_RS20335	COG2207	Transcriptional regulator
AL537_RS20340	COG4771	TonB-dependent receptor
AL537_RS20340	COG1629	transport
AL537_RS20370	COG1289	transmembrane transporter activity
AL537_RS20375	COG0210	DNA helicase
AL537_RS20380	COG1803	Methylglyoxal synthase
AL537_RS20385	COG1879	ABC-type sugar transport system periplasmic component
AL537_RS20390	COG2205	protein histidine kinase activity
AL537_RS20390	COG2198	Histidine kinase
AL537_RS20390	COG0784	Response regulator, receiver
AL537_RS20410	COG3119	arylsulfatase activity
AL537_RS20420	COG3119	arylsulfatase activity
AL537_RS20425	COG0641	radical SAM
AL537_RS20430	COG0714	Associated with various cellular activities
AL537_RS20460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_RS20460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL537_RS20465	COG0583	DNA-binding transcription factor activity
AL537_RS20470	COG1597	lipid kinase activity
AL537_RS20475	COG3111	PFAM Bacterial OB fold (BOF) protein
AL537_RS20500	COG0501	Belongs to the peptidase M48B family
AL537_RS20505	COG1704	LemA family
AL537_RS20510	COG3069	C4-dicarboxylate transmembrane transporter activity
AL537_RS20520	COG0456	acetyltransferase
AL537_RS20520	COG1214	PFAM Peptidase M22, glycoprotease
AL537_RS20540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL537_RS20580	COG2003	Belongs to the UPF0758 family
AL537_RS20615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL537_RS20645	COG3121	Chaperone
AL537_RS20650	COG3188	usher protein
AL537_RS20670	COG0582	viral genome integration into host DNA
AL537_RS20675	COG3300	MHYT domain
AL537_RS20675	COG5001	Diguanylate cyclase
AL537_RS20680	COG3706	GGDEF domain
AL537_RS20690	COG2197	response regulator
AL537_RS20695	COG0835	chemotaxis
AL537_RS20695	COG0784	Response regulator, receiver
AL537_RS20710	COG2962	Rard protein
AL537_RS20775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL537_RS20780	COG5642	Protein of unknown function (DUF2384)
AL537_RS20800	COG1902	pentaerythritol trinitrate reductase activity
AL537_RS20805	COG0346	lactoylglutathione lyase activity
AL537_RS20830	COG2239	Acts as a magnesium transporter
AL537_RS20865	COG0242	peptide deformylase activity
AL537_RS20905	COG2176	DNA-directed DNA polymerase activity
AL537_RS20930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL537_RS20935	COG0697	spore germination
AL537_RS20945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL537_RS20955	COG0346	lactoylglutathione lyase activity
AL537_RS20960	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL537_RS20960	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL537_RS20965	COG0509	glycine decarboxylation via glycine cleavage system
AL537_RS20970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL537_RS20980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL537_RS20990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_RS21010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_RS21010	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL537_RS21010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_RS21015	COG1105	Belongs to the carbohydrate kinase PfkB family
AL537_RS21020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS21020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS21025	COG1609	Transcriptional regulator
AL537_RS21040	COG2199	diguanylate cyclase activity
AL537_RS21040	COG2200	EAL domain
AL537_RS21040	COG2203	Gaf domain
AL537_RS21045	COG0765	amino acid transport
AL537_RS21050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_RS21055	COG0765	amino acid transport
AL537_RS21060	COG1126	abc transporter atp-binding protein
AL537_RS21070	COG1979	alcohol dehydrogenase
AL537_RS21075	COG2207	Transcriptional regulator
AL537_RS21090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL537_RS21095	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL537_RS21100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL537_RS21115	COG0546	phosphoglycolate phosphatase activity
AL537_RS21140	COG0513	Belongs to the DEAD box helicase family
AL537_RS21145	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL537_RS21160	COG3038	cytochrome b561
AL537_RS21165	COG2353	YceI-like domain
AL537_RS21170	COG2116	formate transmembrane transporter activity
AL537_RS21180	COG0583	DNA-binding transcription factor activity
AL537_RS21190	COG3593	DNA synthesis involved in DNA repair
AL537_RS21195	COG0737	Belongs to the 5'-nucleotidase family
AL537_RS21220	COG2267	carboxylic ester hydrolase activity
AL537_RS21225	COG2067	long-chain fatty acid transport protein
AL537_RS21240	COG2050	protein possibly involved in aromatic compounds catabolism
AL537_RS21250	COG4533	DNA binding
AL537_RS21285	COG5001	Diguanylate cyclase
AL537_RS21285	COG1716	ATPase activity
AL537_RS21290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL537_RS21300	COG4181	ATPase activity
AL537_RS21305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL537_RS21315	COG1984	allophanate hydrolase subunit 2
AL537_RS21320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL537_RS21325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL537_RS21330	COG5001	Diguanylate cyclase
AL537_RS21330	COG5002	protein histidine kinase activity
AL537_RS21330	COG3447	MASE1 domain protein
AL537_RS21335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL537_RS21350	COG0583	DNA-binding transcription factor activity
AL537_RS21355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_RS21355	COG1042	CoA-binding domain protein
AL537_RS21355	COG0045	succinate-CoA ligase (ADP-forming) activity
AL537_RS21370	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL537_RS21380	COG0023	Translation Initiation Factor
AL537_RS21385	COG4128	Pfam Zonular occludens toxin
AL537_RS21430	COG4128	Pfam Zonular occludens toxin
AL537_RS21595	COG0589	response to stress
AL537_RS21600	COG3140	Belongs to the UPF0181 family
AL537_RS21625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL537_RS21630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL537_RS21655	COG5001	Diguanylate cyclase
AL537_RS21655	COG3706	GGDEF domain
AL537_RS21655	COG4251	negative regulation of phosphorylation
AL537_RS21655	COG2203	Gaf domain
AL537_RS21665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL537_RS21670	COG4149	molybdate abc transporter
AL537_RS21675	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL537_RS21685	COG3111	PFAM Bacterial OB fold (BOF) protein
AL537_RS21695	COG4067	protein conserved in archaea
AL537_RS21695	COG0189	ligase activity
AL537_RS21705	COG2207	Transcriptional regulator
AL537_RS21710	COG0534	Mate efflux family protein
AL537_RS21715	COG0602	queuosine metabolic process
AL537_RS21720	COG1328	CTP reductase activity
AL537_RS21735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_RS21765	COG1794	racemase activity, acting on amino acids and derivatives
AL537_RS21770	COG0384	phenazine biosynthesis protein PhzF
AL537_RS21780	COG0243	molybdopterin cofactor binding
AL537_RS21795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL537_RS21805	COG2197	response regulator
AL537_RS21810	COG3851	Histidine kinase
AL537_RS21815	COG2271	Major facilitator Superfamily
AL537_RS21840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL537_RS21845	COG3118	belongs to the thioredoxin family
AL537_RS21885	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL537_RS21905	COG2116	formate transmembrane transporter activity
AL537_RS21915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_RS21920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL537_RS21930	COG5001	Diguanylate cyclase
AL537_RS22150	COG1328	CTP reductase activity
AL537_RS22155	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AL537_RS22200	COG2176	DNA-directed DNA polymerase activity
AL537_RS22240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL537_RS22255	COG0277	FAD linked oxidase domain protein
AL537_RS22260	COG0583	DNA-binding transcription factor activity
AL537_RS22275	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL537_RS22290	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL537_RS22300	COG1288	antiporter activity
AL537_RS22310	COG3040	lipid binding
AL537_RS22320	COG0419	ATPase involved in DNA repair
AL537_RS22325	COG0420	3'-5' exonuclease activity
AL537_RS22395	COG0631	protein serine/threonine phosphatase activity
AL537_RS22430	COG2815	serine threonine protein kinase
AL537_RS22430	COG0515	serine threonine protein kinase
AL537_RS22480	COG2146	nitrite reductase [NAD(P)H] activity
AL537_RS22480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_RS22485	COG1116	anion transmembrane transporter activity
AL537_RS22490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL537_RS22495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL537_RS22495	COG1116	anion transmembrane transporter activity
AL537_RS22525	COG0243	molybdopterin cofactor binding
AL537_RS22535	COG0814	amino acid
AL537_RS22595	COG2847	Copper chaperone PCu(A)C
AL537_RS22600	COG0443	Heat shock 70 kDa protein
AL537_RS22670	COG4160	amino acid transport
AL537_RS22675	COG4215	(ABC) transporter
AL537_RS22680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_RS22685	COG1126	abc transporter atp-binding protein
AL537_RS22715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL537_RS22725	COG1012	belongs to the aldehyde dehydrogenase family
AL537_RS22745	COG1902	pentaerythritol trinitrate reductase activity
AL537_RS22745	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL537_RS22750	COG0109	protoheme IX farnesyltransferase activity
AL537_RS22755	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL537_RS22760	COG1845	cytochrome c oxidase, subunit III
AL537_RS22765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL537_RS22770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL537_RS22775	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS22785	COG1024	Enoyl-CoA hydratase
AL537_RS22790	COG1024	Enoyl-CoA hydratase
AL537_RS22805	COG0183	Belongs to the thiolase family
AL537_RS22815	COG1960	acyl-CoA dehydrogenase activity
AL537_RS22820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL537_RS22825	COG1024	Enoyl-CoA hydratase
AL537_RS22835	COG5413	integral membrane protein
AL537_RS22845	COG0247	lactate metabolic process
AL537_RS22845	COG0277	FAD linked oxidase domain protein
AL537_RS22900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL537_RS22915	COG0513	Belongs to the DEAD box helicase family
AL537_RS22920	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL537_RS22950	COG0840	transmembrane signaling receptor activity
AL537_RS22955	COG1119	ATPase activity
AL537_RS22960	COG2200	EAL domain
AL537_RS22980	COG0513	Belongs to the DEAD box helicase family
AL537_RS22985	COG0523	cobalamin synthesis protein
AL537_RS22995	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL537_RS23005	COG1278	Cold shock
AL537_RS23010	COG0557	exoribonuclease II activity
AL537_RS23015	COG0133	tryptophan synthase activity
AL537_RS23025	COG4628	conserved protein (DUF2132)
AL537_RS23030	COG0513	Belongs to the DEAD box helicase family
AL537_RS23040	COG0730	response to heat
AL537_RS23065	COG1278	Cold shock
AL537_RS23085	COG0330	HflC and HflK could
AL537_RS23100	COG0861	Integral membrane protein TerC family
AL537_RS23105	COG1028	Short-chain dehydrogenase reductase Sdr
AL537_RS23115	COG3217	Mosc domain protein beta barrel domain protein
AL537_RS23115	COG0633	Ferredoxin
AL537_RS23125	COG0583	DNA-binding transcription factor activity
AL537_RS23130	COG0596	Alpha beta hydrolase
AL537_RS23140	COG2814	Major facilitator Superfamily
AL537_RS23145	COG3246	L-lysine catabolic process to acetate
AL537_RS23155	COG0183	Belongs to the thiolase family
AL537_RS23160	COG0113	porphobilinogen synthase activity
AL537_RS23185	COG1404	Belongs to the peptidase S8 family
AL537_RS23205	COG3530	Putative quorum-sensing-regulated virulence factor
AL537_RS23230	COG3186	Phenylalanine-4-hydroxylase
AL537_RS23235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL537_RS23240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL537_RS23265	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL537_RS23270	COG1454	alcohol dehydrogenase
AL537_RS23275	COG2133	pyrroloquinoline quinone binding
AL537_RS23285	COG0783	Belongs to the Dps family
AL537_RS23290	COG0840	transmembrane signaling receptor activity
AL537_RS23300	COG1136	(ABC) transporter
AL537_RS23300	COG0577	efflux transmembrane transporter activity
AL537_RS23320	COG2199	diguanylate cyclase activity
AL537_RS23325	COG3036	rescue of stalled ribosome
AL537_RS23330	COG1278	Cold shock
AL537_RS23360	COG0545	Peptidyl-prolyl cis-trans isomerase
AL537_RS23365	COG0109	protoheme IX farnesyltransferase activity
AL537_RS23370	COG1612	heme a metabolic process
AL537_RS23395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL537_RS23400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL537_RS23405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL537_RS23410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL537_RS23420	COG1280	lysine exporter protein (LysE YggA)
AL537_RS23425	COG2207	Transcriptional regulator
AL537_RS23440	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL537_RS23455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_RS23460	COG0697	spore germination
AL537_RS23480	COG2814	Major facilitator Superfamily
AL537_RS23485	COG0583	DNA-binding transcription factor activity
AL537_RS23490	COG5001	Diguanylate cyclase
AL537_RS23495	COG0739	heme binding
AL537_RS23520	COG3314	Sporulation integral membrane protein YlbJ
AL537_RS23525	COG0840	transmembrane signaling receptor activity
AL537_RS23535	COG0814	amino acid
AL537_RS23550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL537_RS23555	COG1072	(Pantothenic acid kinase))
AL537_RS23565	COG1063	alcohol dehydrogenase
AL537_RS23570	COG2213	PTS system mannitol-specific
AL537_RS23575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS23590	COG0798	PFAM Bile acid sodium symporter
AL537_RS23600	COG1881	PFAM PEBP family protein
AL537_RS23610	COG2706	6-phosphogluconolactonase activity
AL537_RS23620	COG1131	(ABC) transporter
AL537_RS23625	COG0842	Transport permease protein
AL537_RS23640	COG3383	formate dehydrogenase (NAD+) activity
AL537_RS23665	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL537_RS23695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL537_RS23705	COG2067	long-chain fatty acid transport protein
AL537_RS23715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL537_RS23725	COG1505	serine-type exopeptidase activity
AL537_RS23730	COG0488	(ABC) transporter
AL537_RS23735	COG0589	response to stress
AL537_RS23740	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL537_RS23760	COG0366	Alpha amylase catalytic
AL537_RS23765	COG0789	Transcriptional regulator
AL537_RS23785	COG4934	collagen metabolic process
AL537_RS23795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL537_RS23800	COG0583	DNA-binding transcription factor activity
AL537_RS23825	COG2610	gluconate transmembrane transporter activity
AL537_RS23830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL537_RS23835	COG3622	Belongs to the hyi family
AL537_RS23840	COG0235	Class ii aldolase
AL537_RS23845	COG3395	kinase activity
AL537_RS23850	COG2084	Dehydrogenase
AL537_RS23855	COG1349	DNA-binding transcription factor activity
AL537_RS23865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL537_RS23870	COG0784	Response regulator, receiver
AL537_RS23870	COG0835	chemotaxis
AL537_RS23880	COG0748	coenzyme F420 binding
AL537_RS23885	COG3721	Heme iron utilization protein
AL537_RS23895	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL537_RS23900	COG0811	peptide transport
AL537_RS23905	COG0848	biopolymer transport protein
AL537_RS23915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_RS23920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL537_RS23960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL537_RS23965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL537_RS23970	COG3217	Mosc domain protein beta barrel domain protein
AL537_RS23970	COG0633	Ferredoxin
AL537_RS23970	COG3217	Mosc domain protein beta barrel domain protein
AL537_RS23970	COG0633	Ferredoxin
AL537_RS23975	COG0401	homolog of Blt101
AL537_RS23985	COG0418	dihydroorotase activity
AL537_RS23990	COG2354	Protein conserved in bacteria
AL537_RS24020	COG0183	Belongs to the thiolase family
AL537_RS24115	COG0804	urea catabolic process
AL537_RS24135	COG0747	negative chemotaxis
AL537_RS24145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL537_RS24160	COG2207	Transcriptional regulator
AL537_RS24190	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL537_RS24270	COG4790	Type iii secretion
AL537_RS24280	COG3710	Transcriptional regulator
AL537_RS24310	COG4792	protein secretion
AL537_RS24315	COG4789	Type iii secretion
AL537_RS24450	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL537_RS24460	COG3344	reverse transcriptase
AL537_RS24575	COG3833	ABC-type maltose transport systems, permease component
AL537_RS24580	COG1175	transmembrane transport
AL537_RS24590	COG3842	ATPase activity
AL537_RS24595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL537_RS24610	COG0489	protein tyrosine kinase activity
AL537_RS24610	COG3206	protein involved in exopolysaccharide biosynthesis
AL537_RS24650	COG3097	Belongs to the UPF0267 family
AL537_RS24655	COG1309	transcriptional regulator
AL537_RS24660	COG2130	NADP-dependent
AL537_RS24670	COG0753	catalase activity
AL537_RS24675	COG2084	Dehydrogenase
AL537_RS24680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_RS24685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_RS24695	COG2207	Transcriptional regulator
AL537_RS24700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_RS24700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL537_RS24700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL537_RS24730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL537_RS24735	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL537_RS24740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL537_RS24750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL537_RS24755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL537_RS24760	COG1012	belongs to the aldehyde dehydrogenase family
AL537_RS24775	COG0583	DNA-binding transcription factor activity
AL537_RS24780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL537_RS24785	COG0569	domain protein
AL537_RS24795	COG2205	protein histidine kinase activity
AL537_RS24800	COG1132	(ABC) transporter
AL537_RS24805	COG4774	siderophore transport
AL537_RS24810	COG1120	ATPase activity
AL537_RS24815	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL537_RS24850	COG2197	response regulator
AL537_RS24860	COG0840	transmembrane signaling receptor activity
AL537_RS24870	COG0714	Associated with various cellular activities
AL537_RS24885	COG2304	oxidoreductase activity
AL537_RS24890	COG2304	oxidoreductase activity
AL537_RS24905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL537_RS24910	COG0581	inorganic phosphate transmembrane transporter activity
AL537_RS24915	COG0573	inorganic phosphate transmembrane transporter activity
AL537_RS24950	COG1770	oligopeptidase
AL537_RS24955	COG0513	Belongs to the DEAD box helicase family
AL537_RS24965	COG1376	ErfK ybiS ycfS ynhG family protein
AL537_RS24965	COG1388	LysM domain
AL537_RS24970	COG0415	Belongs to the DNA photolyase family
AL537_RS24975	COG0789	Transcriptional regulator
AL537_RS24980	COG3272	Protein of unknown function (DUF1722)
AL537_RS24985	COG0813	purine-nucleoside phosphorylase activity
AL537_RS25010	COG1566	PFAM secretion protein HlyD family protein
AL537_RS25015	COG4720	Psort location CytoplasmicMembrane, score
AL537_RS25020	COG1122	ATPase activity
AL537_RS25040	COG0348	domain, Protein
AL537_RS25045	COG0437	4 iron, 4 sulfur cluster binding
AL537_RS25050	COG1247	-acetyltransferase
AL537_RS25070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL537_RS25075	COG0840	transmembrane signaling receptor activity
AL537_RS25080	COG1067	ATP-dependent peptidase activity
AL537_RS25090	COG4172	Belongs to the ABC transporter superfamily
AL537_RS25095	COG1505	serine-type exopeptidase activity
AL537_RS25100	COG0583	DNA-binding transcription factor activity
AL537_RS25105	COG1620	l-lactate permease
AL537_RS25110	COG1304	FMN binding
AL537_RS25120	COG0668	transmembrane transport
AL537_RS25155	COG1063	alcohol dehydrogenase
AL537_RS25160	COG0156	8-amino-7-oxononanoate synthase activity
AL537_RS25165	COG5001	Diguanylate cyclase
AL537_RS25165	COG3300	MHYT domain
AL537_RS25170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL537_RS25190	COG0745	RESPONSE REGULATOR receiver
AL537_RS25215	COG0346	lactoylglutathione lyase activity
AL537_RS25270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL537_RS25310	COG1987	bacterial-type flagellum assembly
AL537_RS25320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL537_RS25335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL537_RS25355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL537_RS25360	COG1516	flagellar protein fliS
AL537_RS25375	COG1580	Controls the rotational direction of flagella during chemotaxis
AL537_RS25380	COG1191	sigma factor activity
AL537_RS25385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL537_RS25390	COG1360	Flagellar Motor Protein
AL537_RS25445	COG1882	Formate acetyltransferase
AL537_RS25450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL537_RS25455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL537_RS25465	COG0454	-acetyltransferase
AL537_RS25475	COG2814	Major facilitator Superfamily
AL537_RS25520	COG0628	permease
AL537_RS25525	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL537_RS25540	COG4628	conserved protein (DUF2132)
AL537_RS25545	COG0583	DNA-binding transcription factor activity
AL537_RS25570	COG1686	Belongs to the peptidase S11 family
AL537_RS25585	COG1054	Belongs to the UPF0176 family
AL537_RS25595	COG0415	Belongs to the DNA photolyase family
AL537_RS25600	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AL537_RS25605	COG3397	chitin binding
AL537_RS25610	COG4667	esterase of the alpha-beta hydrolase superfamily
AL537_RS25615	COG2095	MarC family integral membrane protein
AL537_RS25630	COG1596	polysaccharide export
AL537_RS25635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL537_RS25650	COG1301	dicarboxylic acid transport
AL537_RS25670	COG3339	Conserved Protein
AL537_RS25680	COG0700	Nucleoside recognition
AL537_RS25685	COG3366	ferrous iron transmembrane transporter activity
AL537_RS25700	COG0366	Alpha amylase catalytic
AL537_RS25705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL537_RS25710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL537_RS25715	COG1640	4-alpha-glucanotransferase
AL537_RS25720	COG0058	SHG alpha-glucan phosphorylase activity
AL537_RS25730	COG2909	trisaccharide binding
AL537_RS25745	COG1999	signal sequence binding
AL537_RS25750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL537_RS25750	COG1263	PTS System
AL537_RS25755	COG1162	GTPase activity
AL537_RS25760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL537_RS25765	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL537_RS25775	COG0531	amino acid
AL537_RS25780	COG1982	Orn Lys Arg decarboxylase major
AL537_RS25800	COG2356	endonuclease I
AL537_RS25820	COG4580	involved in the transport of maltose and maltodextrins
AL537_RS25835	COG2814	Major facilitator Superfamily
AL537_RS25860	COG0739	heme binding
AL537_RS25870	COG0612	Peptidase, M16
AL537_RS25875	COG0840	transmembrane signaling receptor activity
AL537_RS25880	COG1120	ATPase activity
AL537_RS25885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_RS25890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL537_RS25895	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL537_RS25900	COG4772	TonB-dependent receptor
AL537_RS25925	COG4264	IucA IucC family
AL537_RS25930	COG0019	diaminopimelate decarboxylase activity
AL537_RS25935	COG1653	transport