locus-tag class description AL468_RS00015 ENOG4105VUF Transcriptional regulator AL468_RS00020 ENOG4108Z8I decarboxylase AL468_RS00030 ENOG4105KXC Collagenase AL468_RS00045 ENOG4105CR8 Transcriptional regulator AL468_RS00050 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS00060 ENOG41061MD high-affinity nickel-transporter AL468_RS00065 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter AL468_RS00070 ENOG4105C6Z Gluconate AL468_RS00075 ENOG4105EXW epimerase dehydratase AL468_RS00080 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AL468_RS00085 ENOG4105FB2 class II Aldolase AL468_RS00090 ENOG4105G63 Type III effector Hrp-dependent AL468_RS00095 ENOG4105ZXK Dehydrogenase AL468_RS00100 ENOG4105MVE transcriptional regulator AL468_RS00110 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AL468_RS00125 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related AL468_RS00130 ENOG41090JE Utilization Protein AL468_RS00135 ENOG4105D4P Coproporphyrinogen iii oxidase AL468_RS00140 ENOG4105WQ5 TonB family AL468_RS00145 ENOG41090AP transport protein AL468_RS00150 ENOG4106GFD transport protein AL468_RS00160 ENOG4105EHG Permease protein AL468_RS00165 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AL468_RS00205 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AL468_RS00210 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AL468_RS00215 ENOG4105QVC MOSC domain-containing protein AL468_RS00215 ENOG4105QVC MOSC domain-containing protein AL468_RS00230 ENOG4105EKE dihydroorotase AL468_RS00235 ENOG4105CKW Inner membrane protein yedI AL468_RS00265 ENOG4105EG2 ABC transporter, permease AL468_RS00270 ENOG4105D56 permease protein AL468_RS00275 ENOG4107FKK extracellular solute-binding protein family 1 AL468_RS00280 ENOG4108IJ9 (ABC) transporter AL468_RS00285 ENOG4105D3Q Sugar transferase AL468_RS00300 ENOG4105D75 Capsular exopolysaccharide family AL468_RS00340 ENOG4105V0I UPF0267 protein AL468_RS00345 ENOG4108WUH Transcriptional regulator, TetR family AL468_RS00350 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AL468_RS00355 ENOG4108RXX maleylacetoacetate isomerase AL468_RS00360 ENOG4105CH6 catalase AL468_RS00365 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL468_RS00370 ENOG4105DM4 PTS System AL468_RS00375 ENOG4108YRF PTS System AL468_RS00385 ENOG4106R3P AraC family transcriptional regulator AL468_RS00390 ENOG4105DM4 PTS System AL468_RS00395 ENOG4105EIP mannose-6-phosphate isomerase AL468_RS00415 ENOG4108JUA Transcriptional regulator AL468_RS00420 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AL468_RS00430 ENOG4105CK1 PTS System AL468_RS00440 ENOG4105CJP fad dependent oxidoreductase AL468_RS00445 ENOG4107QZF nitrite reductase NADPH large subunit AL468_RS00455 ENOG4105DVW rieske (2Fe-2S) AL468_RS00465 ENOG4105ETT transcriptional Regulator, LysR family AL468_RS00470 ENOG4105CZN Potassium uptake protein AL468_RS00480 ENOG4105EEX Two component transcriptional regulator (Winged helix family AL468_RS00490 ENOG4105BZ1 (ABC) transporter AL468_RS00495 ENOG4105E0K tonB-dependent siderophore receptor AL468_RS00500 ENOG4105E0A ABC, transporter AL468_RS00505 ENOG4108HUF Transporter AL468_RS00510 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL468_RS00525 ENOG4108JJ6 Type I secretion system ATPase AL468_RS00535 ENOG41086KC Transcriptional regulator AL468_RS00540 ENOG41086KC Transcriptional regulator AL468_RS00550 ENOG41069D7 Methyl-accepting chemotaxis AL468_RS00560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL468_RS00575 ENOG4107QVM von Willebrand factor, type A AL468_RS00595 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL468_RS00600 ENOG4105E2Z phosphate ABC transporter (Permease AL468_RS00605 ENOG4105C8U phosphate abc transporter AL468_RS00615 ENOG4108NVR Methyl-accepting chemotaxis AL468_RS00635 ENOG4105D05 Receptor AL468_RS00640 ENOG4105CUG Oligopeptidase b AL468_RS00645 ENOG4105C1J atp-dependent rna helicase AL468_RS00655 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AL468_RS00660 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL468_RS00665 ENOG4108XDN Transcriptional regulator AL468_RS00670 ENOG4107SEY Conserved Protein AL468_RS00675 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL468_RS00690 ENOG4106TD9 Diguanylate cyclase AL468_RS00695 ENOG4105KK7 inner membrane protein YiaW AL468_RS00700 ENOG4105EFX secretion protein, HlyD family AL468_RS00705 ENOG4108V7D UPF0397 protein AL468_RS00710 ENOG4108JJB ABC transporter AL468_RS00730 ENOG4105GXZ Ferredoxin-type protein NapH AL468_RS00735 ENOG4108BGM Quinol dehydrogenase periplasmic component AL468_RS00740 ENOG4105WCN acetyltransferase AL468_RS00755 ENOG4105YE1 PilZ domain AL468_RS00760 ENOG4107QE9 Inherit from COG: Membrane AL468_RS00765 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS00770 ENOG4105DAN ATP-dependent protease AL468_RS00780 ENOG4108JQ5 ABC transporter AL468_RS00790 ENOG410642W LysR family Transcriptional regulator AL468_RS00795 ENOG4105DAA L-lactate AL468_RS00800 ENOG4105DMF Dehydrogenase AL468_RS00810 ENOG4105D64 Mechanosensitive ion channel AL468_RS00820 ENOG4105CPQ Dehydrogenase AL468_RS00825 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL468_RS00830 ENOG4105BZU Histidine kinase AL468_RS00835 ENOG4107R0W ABC transporter AL468_RS00845 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL468_RS00855 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL468_RS00875 ENOG4105EXG Transcriptional regulator AL468_RS00880 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AL468_RS00895 ENOG4107SSZ Phosphatase AL468_RS00925 ENOG4108JIR Flagellum-specific ATP synthase AL468_RS00935 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL468_RS00940 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL468_RS00965 ENOG4105DD5 Flagellar motor switch protein AL468_RS00970 ENOG4105CN7 Flagellar biosynthetic protein FliP AL468_RS00975 ENOG4105VS8 Flagellar biosynthetic protein fliq AL468_RS00980 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL468_RS00985 ENOG4105D00 flagellar biosynthetic protein flhB AL468_RS01000 ENOG4105I03 Flagellin AL468_RS01010 ENOG410804A Flagellar hook-associated 2 domain-containing protein AL468_RS01015 ENOG4105MQ3 flagellar protein FliS AL468_RS01040 ENOG4107RD7 Flagellar Motor Protein, MotA AL468_RS01045 ENOG4105ER2 Ompa motb domain protein AL468_RS01060 ENOG4105KWG Pfam:DUF1696 AL468_RS01105 ENOG4105F1A Pyruvate formate-lyase AL468_RS01110 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL468_RS01120 ENOG4105I4A GCN5-related N-acetyltransferase AL468_RS01130 ENOG4105CNH Multidrug resistance protein MdtL AL468_RS01135 ENOG4105G2Y Transcriptional regulator AL468_RS01175 ENOG4105IPI Membrane AL468_RS01180 ENOG41068P6 UPF0319 protein AL468_RS01185 ENOG4105DP0 ferredoxin-NADP reductase AL468_RS01195 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL468_RS01200 ENOG4105ETT transcriptional Regulator, LysR family AL468_RS01210 ENOG4108RCM Nitroreductase AL468_RS01215 ENOG4108ZX5 transcriptional regulator AL468_RS01225 ENOG4105DZ1 carboxypeptidase AL468_RS01240 ENOG4105C72 UPF0176 protein AL468_RS01250 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL468_RS01260 ENOG4108M1A Chitin-binding protein AL468_RS01265 ENOG4108NRW Phospholipase, patatin family AL468_RS01270 ENOG41081FY multiple antibiotic resistance (MarC)-related AL468_RS01285 ENOG4105DAY polysaccharide export protein AL468_RS01290 ENOG4105KJF protein tyrosine phosphatase AL468_RS01305 ENOG4105CK2 sodium dicarboxylate symporter AL468_RS01315 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL468_RS01320 ENOG4108P2H Inner membrane protein YjiG AL468_RS01325 ENOG41074DU domain protein AL468_RS01340 ENOG4107T9C Alpha amylase catalytic region AL468_RS01345 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AL468_RS01350 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AL468_RS01355 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AL468_RS01360 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AL468_RS01370 ENOG41061ZR Transcriptional regulator AL468_RS01395 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL468_RS01400 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AL468_RS01405 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AL468_RS01415 ENOG4105D5Q Arginine ornithine antiporter AL468_RS01420 ENOG4105CXN decarboxylase AL468_RS01440 ENOG4108K8S endonuclease I AL468_RS01460 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AL468_RS01505 ENOG4105DR5 peptidase AL468_RS01515 ENOG4107RAN Peptidase, M16 AL468_RS01520 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS01525 ENOG4105E0A ABC, transporter AL468_RS01530 ENOG4108U1V ABC transporter, permease AL468_RS01535 ENOG4105DQ5 transport system permease protein AL468_RS01540 ENOG4108HUF Transporter AL468_RS01545 ENOG4105GAV receptor AL468_RS01550 ENOG4105E0K tonB-dependent siderophore receptor AL468_RS01560 ENOG4105DUU IucA IucC family protein AL468_RS01570 ENOG4105DBM Siderophore biosynthesis protein AL468_RS01575 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL468_RS01580 ENOG4108JP0 extracellular solute-binding protein family 1 AL468_RS01585 ENOG4105DHQ Histidine kinase AL468_RS01600 ENOG4105CI1 PTS System AL468_RS01615 ENOG4106371 Methyltransferase AL468_RS01625 ENOG4105CKK Glycosyl transferase, family 2 AL468_RS01665 ENOG4108ZHJ Organic hydroperoxide resistance protein AL468_RS01670 ENOG4105K56 Transcriptional regulator AL468_RS01675 ENOG4105D3R alkyl hydroperoxide reductase AL468_RS01680 ENOG4108JU3 Alkyl hydroperoxide reductase AL468_RS01695 ENOG4105EXG Transcriptional regulator AL468_RS01700 ENOG4105ECQ AraC Family Transcriptional Regulator AL468_RS01705 ENOG4108AEY RNA polymerase sigma factor AL468_RS01725 ENOG4108RPX mosc domain containing protein AL468_RS01750 ENOG4105CF7 AraC family transcriptional regulator AL468_RS01760 ENOG4105BZ1 (ABC) transporter AL468_RS01770 ENOG4105EW9 transcriptional regulator AsnC family AL468_RS01780 ENOG4105KNA -acetyltransferase AL468_RS01795 ENOG4105CK7 Sodium proline symporter AL468_RS01805 ENOG4105C26 Dehydrogenase AL468_RS01820 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AL468_RS01825 ENOG4105CQZ Histidine kinase AL468_RS01830 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS01835 ENOG4107QZV Type I secretion membrane fusion protein AL468_RS01875 ENOG4108J59 Extracellular solute-binding protein, family 5 AL468_RS01885 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) AL468_RS01895 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL468_RS01900 ENOG4105C5Y PTS System AL468_RS01905 ENOG4105FCK Membrane AL468_RS01910 ENOG4105EC3 peptidase S51, dipeptidase E AL468_RS01915 ENOG4105EQ2 LysR family Transcriptional regulator AL468_RS01930 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AL468_RS01955 ENOG4108JQ7 (ABC) transporter AL468_RS01980 ENOG4105BZU Histidine kinase AL468_RS01990 ENOG4105CDY transcriptional regulatory protein AL468_RS01995 ENOG4105CNI cell division protein FtsW AL468_RS02005 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL468_RS02025 ENOG4108HRK Histidine kinase AL468_RS02030 ENOG4108VAC response regulator AL468_RS02040 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL468_RS02045 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS02060 ENOG4105D6U Sodium Glutamate Symporter AL468_RS02070 ENOG4105CZV ABC transporter AL468_RS02075 ENOG4107U9B transcriptional regulator AL468_RS02080 ENOG4105D6U Sodium Glutamate Symporter AL468_RS02090 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AL468_RS02110 ENOG4105C2I pirin domain protein AL468_RS02115 ENOG4108VGI doxx family AL468_RS02125 ENOG4105D03 DNA-3-methyladenine glycosylase II AL468_RS02150 ENOG4105DN9 Na H antiporter AL468_RS02165 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_RS02180 ENOG4105NBK UPF0345 protein AL468_RS02190 ENOG4105BZU Histidine kinase AL468_RS02195 ENOG4105UQX Mate efflux family protein AL468_RS02200 ENOG4105D3G Pseudouridine synthase AL468_RS02215 ENOG4105EJC lysr family transcriptional regulator AL468_RS02220 ENOG4108HCJ Hydrolase AL468_RS02230 ENOG4108KHX Diguanylate cyclase AL468_RS02250 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AL468_RS02255 ENOG4105CC0 LysR family Transcriptional regulator AL468_RS02260 ENOG4105Q26 Siderophore-interacting protein AL468_RS02275 ENOG4105EW9 transcriptional regulator AsnC family AL468_RS02295 ENOG4107W31 Pentapeptide repeat protein AL468_RS02300 ENOG4105EIF outer membrane protein W AL468_RS02310 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL468_RS02330 ENOG4107WCA isomerase AL468_RS02335 ENOG4108UVJ appr-1-p processing domain protein AL468_RS02340 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AL468_RS02345 ENOG4108WAV Transcriptional regulator AL468_RS02390 ENOG4105BZU Histidine kinase AL468_RS02425 ENOG4105VEQ Cold shock protein AL468_RS02430 ENOG4107QM5 aconitate hydratase AL468_RS02435 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AL468_RS02445 ENOG4107QJR hflk protein AL468_RS02455 ENOG4105VEQ Cold shock protein AL468_RS02460 ENOG4105CZN Potassium uptake protein AL468_RS02470 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL468_RS02475 ENOG4105EEX Two component transcriptional regulator (Winged helix family AL468_RS02480 ENOG4105C08 Histidine kinase AL468_RS02485 ENOG4105D64 Mechanosensitive ion channel AL468_RS02490 ENOG4105CJ2 (LipO)protein AL468_RS02500 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AL468_RS02550 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL468_RS02710 ENOG4105S8Q sugar efflux transporter AL468_RS02740 ENOG41079PT Aminoacyl carrier protein. Can be charged with L-glycine via the formation of a thioester bond between the amino acid and the 4'-phosphopantetheinyl prosthetic group, catalyzed by the AL468_RS02750 ENOG4105C0W non-ribosomal peptide synthetase AL468_RS02765 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_RS02770 ENOG4108TSE Transferase AL468_RS02815 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AL468_RS02840 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AL468_RS02845 ENOG4105C6Z Gluconate AL468_RS02850 ENOG4105BZW Glycerate kinase AL468_RS02855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_RS02890 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL468_RS02895 ENOG41068WN AL468_RS02900 ENOG4105CUW cytochrome C-TYPE protein AL468_RS02905 ENOG4107QY8 reductase AL468_RS02915 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AL468_RS02920 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AL468_RS02925 ENOG4105ETU transcriptional activator (TenA AL468_RS02930 ENOG4107Z6I Thiamine biosynthesis protein AL468_RS02935 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AL468_RS02940 ENOG4108YI8 ABC transporter AL468_RS02945 ENOG4105DWF phosphomethylpyrimidine kinase AL468_RS02960 ENOG4108TEM pseudouridine methyltransferase AL468_RS03015 ENOG4108YYI Protein of unknown function (DUF2810) AL468_RS03020 ENOG4105C5I Dehydrogenase AL468_RS03030 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AL468_RS03040 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL468_RS03045 ENOG410804D Sensor Signal Transduction Histidine Kinase AL468_RS03070 ENOG4109015 Biopolymer transport protein exbD tolR AL468_RS03115 ENOG4105DSE periplasmic solute binding protein AL468_RS03120 ENOG4105DIK (ABC) transporter AL468_RS03125 ENOG4105CC5 ABC transporter AL468_RS03140 ENOG4105CUG Oligopeptidase b AL468_RS03145 ENOG4105E5M Multidrug resistance protein D AL468_RS03150 ENOG4105CYW agmatinase AL468_RS03155 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AL468_RS03165 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_RS03170 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_RS03175 ENOG4105DUM transcriptional regulator, lysR family AL468_RS03220 ENOG4106TD9 Diguanylate cyclase AL468_RS03225 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL468_RS03245 ENOG4105D5U fad dependent oxidoreductase AL468_RS03250 ENOG4108MTT Glutamate-rich protein grpB AL468_RS03270 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL468_RS03275 ENOG4105C4M (Ubiquinol oxidase) subunit I AL468_RS03280 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_RS03285 ENOG4105C0F tryptophanase EC 4.1.99.1 AL468_RS03305 ENOG4105D9N nucleoside AL468_RS03320 ENOG4105BZU Histidine kinase AL468_RS03335 ENOG4106TD9 Diguanylate cyclase AL468_RS03340 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL468_RS03345 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein AL468_RS03360 ENOG4105E0X reductase AL468_RS03365 ENOG4108UKZ OsmC family AL468_RS03370 ENOG4108UW5 maltose o-acetyltransferase AL468_RS03405 ENOG4105JQN Transcriptional regulator AL468_RS03410 ENOG4105PAD Hydrolase AL468_RS03425 ENOG4108UUE Transcriptional regulator AL468_RS03435 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_RS03445 ENOG4105KUU lipolytic protein G-D-S-L family AL468_RS03475 ENOG4105ETE Transcriptional regulator (LacI family AL468_RS03480 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AL468_RS03485 ENOG4108JPW Aminotransferase AL468_RS03505 ENOG4107RCV ABC transporter, permease AL468_RS03525 ENOG4108MJ5 VirK protein AL468_RS03535 ENOG4105CJP fad dependent oxidoreductase AL468_RS03550 ENOG4105ETT transcriptional Regulator, LysR family AL468_RS03570 ENOG4105DUX Transporter AL468_RS03575 ENOG4105EJQ L-serine dehydratase AL468_RS03595 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL468_RS03600 ENOG4105E4C Lytic transglycosylase catalytic AL468_RS03620 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL468_RS03625 ENOG4108ZC9 flagellar basal-body rod protein flgc AL468_RS03630 ENOG4105W00 Flagellar hook capping protein AL468_RS03635 ENOG4105BZE flagellar hook protein, FlgE AL468_RS03640 ENOG4108KPB Flagellar basal-body rod protein FlgF AL468_RS03645 ENOG4105CGA flagellar basal-body rod protein FlgG AL468_RS03650 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_RS03655 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_RS03660 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL468_RS03665 ENOG4105E1Q flagellar hook-associated protein AL468_RS03670 ENOG4105DTJ flagellar hook-associated protein AL468_RS03690 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AL468_RS03705 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL468_RS03710 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL468_RS03715 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL468_RS03745 ENOG4107Z3H Transcriptional regulator, TetR family AL468_RS03750 ENOG4108K3Z AraC family transcriptional regulator AL468_RS03755 ENOG4105CPD ethanolamine ammonia-lyase AL468_RS03760 ENOG4107FQ9 ethanolamine ammonia-lyase AL468_RS03765 ENOG4105CUB amino acid AL468_RS03770 ENOG4105EA8 2-Nitropropane dioxygenase AL468_RS03775 ENOG4105CWX Alpha-1,2-mannosidase AL468_RS03780 ENOG4105CWX Alpha-1,2-mannosidase AL468_RS03790 ENOG4105CWX Alpha-1,2-mannosidase AL468_RS03795 ENOG4105CWX Alpha-1,2-mannosidase AL468_RS03800 ENOG4105DM4 PTS System AL468_RS03810 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL468_RS03815 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AL468_RS03820 ENOG4105N2W Transcriptional regulator AL468_RS03830 ENOG4108RWI nicotinamidase AL468_RS03840 ENOG4107RH7 Nicotinate phosphoribosyltransferase AL468_RS03865 ENOG4105ETT transcriptional Regulator, LysR family AL468_RS03880 ENOG4105RW8 MltA-interacting MipA family protein AL468_RS03885 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AL468_RS03890 ENOG4108IJ7 Glycine betaine AL468_RS03895 ENOG4108HQS Glycine betaine AL468_RS03905 ENOG4105VYW UPF0251 protein AL468_RS03930 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL468_RS03940 ENOG4107S8C mandelate racemase muconate lactonizing AL468_RS03950 ENOG4105RQF LysR family Transcriptional regulator AL468_RS03965 ENOG4108Z4X TRANSCRIPTIONal AL468_RS03990 ENOG4107RZC phospholipase d AL468_RS04020 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_RS04075 ENOG4107KET secretion protein, HlyD family AL468_RS04090 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL468_RS04095 ENOG4105WH1 Two component transcriptional regulator luxr family AL468_RS04110 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AL468_RS04115 ENOG4105HDK L-asparaginase AL468_RS04120 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL468_RS04135 ENOG4105N14 lysine exporter protein LysE YggA AL468_RS04140 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AL468_RS04160 ENOG4105C8Y Acetylornithine aminotransferase AL468_RS04165 ENOG4105C26 Dehydrogenase AL468_RS04170 ENOG4108RYR transcriptional regulator AsnC family AL468_RS04175 ENOG4108KJ1 Trap dicarboxylate transporter, dctp subunit AL468_RS04180 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase AL468_RS04185 ENOG4105ENR peptidase, M24 AL468_RS04190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_RS04195 ENOG4108K1J Transporter DctQ AL468_RS04200 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL468_RS04205 ENOG4108NKV transcriptional regulator AL468_RS04210 ENOG4105CHR reductase AL468_RS04220 ENOG4105CPQ Dehydrogenase AL468_RS04225 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_RS04240 ENOG4107RSM transcriptional regulator AL468_RS04250 ENOG4105C1J atp-dependent rna helicase AL468_RS04290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_RS04295 ENOG410874W AraC family transcriptional regulator AL468_RS04315 ENOG4108P3C AL468_RS04330 ENOG4105CHR reductase AL468_RS04355 ENOG4105C5Y PTS System AL468_RS04360 ENOG4105D7K pfkb domain protein AL468_RS04365 ENOG4108HKT sucrose-6-phosphate hydrolase AL468_RS04375 ENOG4105CYM Glutathione S-transferase AL468_RS04385 ENOG4105DZ1 carboxypeptidase AL468_RS04395 ENOG4105EHV domain protein AL468_RS04400 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL468_RS04415 ENOG4105VEQ Cold shock protein AL468_RS04420 ENOG4105EUB pirin domain protein AL468_RS04425 ENOG4108NRW Phospholipase, patatin family AL468_RS04440 ENOG4105EP9 oxidoreductase AL468_RS04445 ENOG4105DIJ Phosphoethanolamine transferase AL468_RS04450 ENOG41080IJ Diacylglycerol kinase AL468_RS04460 ENOG4105E0F Histidine kinase AL468_RS04465 ENOG4107EXC regulatoR AL468_RS04480 ENOG4108Z33 Thiol disulfide Interchange Protein AL468_RS04500 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AL468_RS04510 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL468_RS04525 ENOG4105EST Metal Dependent Phosphohydrolase AL468_RS04530 ENOG4105DZC cytosine deaminase AL468_RS04535 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin AL468_RS04540 ENOG4105CJW magnesium transporter AL468_RS04545 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL468_RS04550 ENOG4105EFX secretion protein, HlyD family AL468_RS04575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL468_RS04580 ENOG4105E0F Histidine kinase AL468_RS04595 ENOG4105DVH amino acid AL468_RS04610 ENOG4105DUM transcriptional regulator, lysR family AL468_RS04635 ENOG4105BZU Histidine kinase AL468_RS04645 ENOG41090HJ UPF0265 protein AL468_RS04655 ENOG4108YXG UPF0502 protein AL468_RS04660 ENOG41082IR Excinuclease ABC C subunit domain protein AL468_RS04670 ENOG4108QGH periplasmic AL468_RS04675 ENOG4105BZU Histidine kinase AL468_RS04685 ENOG4105J12 Multidrug resistance protein mdtN AL468_RS04705 ENOG4105EW9 transcriptional regulator AsnC family AL468_RS04735 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_RS04740 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_RS04760 ENOG4105CHU acetyl-coa acetyltransferase AL468_RS04770 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AL468_RS04780 ENOG4105CUW cytochrome C-TYPE protein AL468_RS04790 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL468_RS04805 ENOG4105BZU Histidine kinase AL468_RS04810 ENOG4105WH1 Two component transcriptional regulator luxr family AL468_RS04825 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL468_RS04830 ENOG4107YWA deoxycytidylate deaminase AL468_RS04845 ENOG4108N3W hemolysin secretion protein AL468_RS04850 ENOG4108YZN class I peptide chain release factor AL468_RS04855 ENOG4107VXZ Hydrolase AL468_RS04860 ENOG4105UYK outer membrane protein a AL468_RS04870 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL468_RS04875 ENOG4105DXI Major Facilitator superfamily AL468_RS04880 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AL468_RS04885 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL468_RS04890 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL468_RS04915 ENOG4105BZU Histidine kinase AL468_RS04920 ENOG4105KHC sulfurtransferase AL468_RS04940 ENOG4105D06 uba thif-type nad fad binding protein AL468_RS04945 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL468_RS04950 ENOG4105EUJ GTP cyclohydrolase i AL468_RS04955 ENOG4105C5A transporter AL468_RS04965 ENOG4105CMQ Chloride channel AL468_RS04980 ENOG4107RGM aldo keto reductase AL468_RS04985 ENOG4108UNF response regulator AL468_RS04995 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AL468_RS05000 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL468_RS05005 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_RS05020 ENOG4105DQU oxidoreductase, subunit beta AL468_RS05025 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AL468_RS05035 ENOG4105DR5 peptidase AL468_RS05060 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS05065 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_RS05070 ENOG4108WC9 type VI secretion system effector, hcp1 family AL468_RS05075 ENOG4105CS6 Rhs element vgr protein AL468_RS05100 ENOG4105D9P serine threonine protein kinase AL468_RS05135 ENOG4105EW9 transcriptional regulator AsnC family AL468_RS05205 ENOG4105ENX hydrolase AL468_RS05210 ENOG4105C2C drug resistance transporter, Bcr CflA AL468_RS05220 ENOG4105CC0 LysR family Transcriptional regulator AL468_RS05225 ENOG4105EMU Dehydrogenase AL468_RS05230 ENOG4105Q9Y Universal stress protein AL468_RS05240 ENOG4105D65 subunit l AL468_RS05245 ENOG4105MKQ Monovalent cation H antiporter subunit C AL468_RS05250 ENOG4108JPZ Monovalent cation H antiporter subunit D AL468_RS05255 ENOG4105SC1 monovalent cation H antiporter subunit E AL468_RS05260 ENOG41080TA Multiple resistance and ph regulation protein f AL468_RS05265 ENOG4105KJM monovalent cation h antiporter subunit g AL468_RS05270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_RS05275 ENOG4105C10 Electron transfer flavoprotein AL468_RS05280 ENOG4105BZJ Electron transfer flavoprotein AL468_RS05285 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL468_RS05295 ENOG4105C0Z ABC transporter AL468_RS05320 ENOG4108IV0 ABC, transporter AL468_RS05325 ENOG4105DZS Phenylacetate-CoA ligase AL468_RS05355 ENOG4105C94 Transporter AL468_RS05360 ENOG4105CHR reductase AL468_RS05365 ENOG4105C7K acetolactate synthase AL468_RS05370 ENOG4107FQX Alpha-acetolactate decarboxylase AL468_RS05380 ENOG4107YBY Hydrolase AL468_RS05385 ENOG4108S58 Phenazine biosynthesis protein PhzF AL468_RS05395 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL468_RS05400 ENOG4105C4M (Ubiquinol oxidase) subunit I AL468_RS05405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_RS05425 ENOG4105BZU Histidine kinase AL468_RS05430 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL468_RS05440 ENOG4108IPT Naphthoate synthase AL468_RS05445 ENOG4107QX3 carboxylase AL468_RS05450 ENOG4105C1G acyl-Coa dehydrogenase AL468_RS05460 ENOG4105CHU acetyl-coa acetyltransferase AL468_RS05465 ENOG4105C26 Dehydrogenase AL468_RS05470 ENOG4105C1G acyl-Coa dehydrogenase AL468_RS05475 ENOG4105E39 Enoyl-CoA hydratase AL468_RS05485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL468_RS05490 ENOG4105CHR reductase AL468_RS05500 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AL468_RS05505 ENOG4105C26 Dehydrogenase AL468_RS05510 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AL468_RS05520 ENOG4108HQS Glycine betaine AL468_RS05525 ENOG4108IJ7 Glycine betaine AL468_RS05530 ENOG4108RCM Nitroreductase AL468_RS05540 ENOG4107QX8 SPFH domain, Band 7 family protein AL468_RS05550 ENOG4105BZU Histidine kinase AL468_RS05555 ENOG4105CA0 peroxidase AL468_RS05560 ENOG4105BZU Histidine kinase AL468_RS05570 ENOG4105D82 Glutamate dehydrogenase AL468_RS05620 ENOG4108K0B C-di-gmp phosphodiesterase AL468_RS05625 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AL468_RS05630 ENOG4105C2J ABC transporter AL468_RS05635 ENOG4105CNN ABC, transporter AL468_RS05640 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AL468_RS05645 ENOG4108RVA ribokinase AL468_RS05650 ENOG4105ETE Transcriptional regulator (LacI family AL468_RS05660 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AL468_RS05665 ENOG4107SXA Phosphorylase AL468_RS05680 ENOG4105DHS permease protein AL468_RS05685 ENOG4105CM4 permease protein AL468_RS05690 ENOG4108IPW abc transporter atp-binding protein AL468_RS05695 ENOG4108Z6Z Transcriptional regulator AL468_RS05700 ENOG4108W3Q Transcriptional regulator AL468_RS05735 ENOG4105EM2 membrane AL468_RS05740 ENOG41088T4 Helicase IV AL468_RS05745 ENOG4108Z5K methylglyoxal synthase AL468_RS05750 ENOG4108SV3 Tmao reductase system periplasmic protein tort AL468_RS05755 ENOG4105BZU Histidine kinase AL468_RS05775 ENOG4105ENH Sulfatase AL468_RS05785 ENOG41061MV Arylsulfatase AL468_RS05790 ENOG4105C4X radical SAM domain protein AL468_RS05795 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL468_RS05825 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL468_RS05830 ENOG41064T2 transcriptional regulator, lysR family AL468_RS05835 ENOG4107TE5 Lipid kinase AL468_RS05840 ENOG4108YDI single-species biofilm formation on inanimate substrate AL468_RS05850 ENOG4105F2V VRR-NUC domain-containing protein AL468_RS05865 ENOG4105D0M Protease HtpX homolog AL468_RS05870 ENOG4108V0P LemA family AL468_RS05875 ENOG4105CEE C4-dicarboxylate transporter AL468_RS05895 ENOG4108MGY Histidine kinase AL468_RS05900 ENOG4107KBT 8-Amino-7-oxononanoate synthase AL468_RS05905 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AL468_RS05910 ENOG4105BZU Histidine kinase AL468_RS05915 ENOG4105BZU Histidine kinase AL468_RS05925 ENOG4108WQH regulatoR AL468_RS05930 ENOG4107R88 Chemotaxis protein (CheV) AL468_RS05935 ENOG4108VAU general secretion pathway protein G AL468_RS05945 ENOG4105FR1 rard protein AL468_RS05975 ENOG4105KPY Small multidrug resistance protein AL468_RS05980 ENOG4108I0N Transporter, RarD family, DMT superfamily protein AL468_RS05995 ENOG4107RGH Aldehyde dehydrogenase AL468_RS06010 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AL468_RS06035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_RS06040 ENOG4108UYE Lactoylglutathione lyase AL468_RS06060 ENOG4105CJW magnesium transporter AL468_RS06090 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL468_RS06105 ENOG4105HDD phospholipase AL468_RS06130 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AL468_RS06165 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AL468_RS06170 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AL468_RS06175 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL468_RS06185 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AL468_RS06195 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL468_RS06215 ENOG4105DM4 PTS System AL468_RS06220 ENOG4105DE4 1-phosphofructokinase AL468_RS06225 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AL468_RS06230 ENOG4107B7Y DNA-binding transcriptional regulator FruR AL468_RS06245 ENOG4108NJZ Sensory box GGDEF EAL domain protein AL468_RS06250 ENOG4105DRP amino acid AbC transporter AL468_RS06255 ENOG4106TNF Periplasmic binding protein AL468_RS06260 ENOG4105E5Q amino acid AbC transporter AL468_RS06265 ENOG4105CDA abc transporter atp-binding protein AL468_RS06275 ENOG4108I6A alcohol dehydrogenase AL468_RS06280 ENOG4105CF7 AraC family transcriptional regulator AL468_RS06295 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL468_RS06300 ENOG4105CKU formyltetrahydrofolate synthetase AL468_RS06305 ENOG4107RE1 Inosine-guanosine kinase AL468_RS06320 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL468_RS06345 ENOG4105C1J atp-dependent rna helicase AL468_RS06350 ENOG4108M8H domain protein AL468_RS06365 ENOG4105DS1 cytochrome b561 AL468_RS06370 ENOG4108YYC ycei family AL468_RS06375 ENOG4105TMB Formate nitrite transporter AL468_RS06385 ENOG4105DUM transcriptional regulator, lysR family AL468_RS06390 ENOG4108UQ5 membrane protein YcdZ AL468_RS06395 ENOG4105CPB ATP-dependent endonuclease of the OLD family AL468_RS06400 ENOG4105CGH 5'-nucleotidase AL468_RS06405 ENOG4105DU1 integral membrane protein, terc AL468_RS06425 ENOG4108M0H Extracellular lipase AL468_RS06430 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_RS06445 ENOG4105KA0 thioesterase Superfamily protein AL468_RS06455 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AL468_RS06495 ENOG4105RKW reductase (By AL468_RS06505 ENOG4108I0Y (ABC) transporter AL468_RS06510 ENOG4105CV6 ABC transporter, permease AL468_RS06520 ENOG4107R7A Allophanate hydrolase subunit 2 AL468_RS06525 ENOG4105P4J Allophanate hydrolase, subunit 1 AL468_RS06530 ENOG4105E7W lamb ycsf family protein AL468_RS06535 ENOG4105BZU Histidine kinase AL468_RS06540 ENOG4105CMR udp-glucose 4-epimerase AL468_RS06555 ENOG4105CWB LysR family transcriptional Regulator AL468_RS06560 ENOG4105CD5 CoA-binding domain protein AL468_RS06570 ENOG4105CPF Cell wall formation (By similarity) AL468_RS06580 ENOG4108ZJT translation initiation factor, Sui1 AL468_RS06630 ENOG4105MQ5 zona occludens toxin AL468_RS06660 ENOG4105EJC lysr family transcriptional regulator AL468_RS06670 ENOG4108M6U Universal stress protein A AL468_RS06700 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL468_RS06705 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL468_RS06740 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AL468_RS06745 ENOG4105E0C molybdate abc transporter AL468_RS06750 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AL468_RS06755 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AL468_RS06760 ENOG4105WXI Bacterial OB fold (BOF) protein AL468_RS06770 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_RS06775 ENOG4105CGF Aromatic amino acid aminotransferase AL468_RS06780 ENOG4108K01 transcriptional regulator AL468_RS06785 ENOG4105UQX Mate efflux family protein AL468_RS06790 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AL468_RS06795 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AL468_RS06810 ENOG4105BZS acriflavin resistance protein AL468_RS06915 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AL468_RS06925 ENOG4107TIF Phenazine biosynthesis protein, PhzF family AL468_RS06935 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AL468_RS06945 ENOG4105C5Q Transcriptional regulator AL468_RS06950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL468_RS06955 ENOG4105CXY transporter AL468_RS06960 ENOG4108KX4 response regulator AL468_RS06965 ENOG4105BZU Histidine kinase AL468_RS06970 ENOG4105CXY transporter AL468_RS06975 ENOG4105EIP mannose-6-phosphate isomerase AL468_RS06995 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL468_RS07000 ENOG4105K63 Thioredoxin AL468_RS07010 ENOG4105VXR cytoplasmic protein AL468_RS07040 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL468_RS07055 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL468_RS07060 ENOG4105TMB Formate nitrite transporter AL468_RS07065 ENOG4105WZK nitrite reductase NADPH small subunit AL468_RS07070 ENOG4107QZF nitrite reductase NADPH large subunit AL468_RS07075 ENOG4105NXH GreA GreB family elongation factor AL468_RS07085 ENOG4105BZU Histidine kinase AL468_RS07160 ENOG4108NVR Methyl-accepting chemotaxis AL468_RS07165 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL468_RS07200 ENOG4105CXG d-lactate dehydrogenase AL468_RS07205 ENOG4105CC0 LysR family Transcriptional regulator AL468_RS07220 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AL468_RS07225 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) AL468_RS07235 ENOG4105C5W Aldolase AL468_RS07240 ENOG4106RE7 Cytochrome AL468_RS07245 ENOG4105CSX c4-dicarboxylate anaerobic carrier AL468_RS07255 ENOG4105QNF Outer membrane lipoprotein AL468_RS07265 ENOG4105EYH Exonuclease AL468_RS07270 ENOG4107RFY SbcCD D subunit AL468_RS07295 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_RS07340 ENOG4108ZF3 Phosphatase AL468_RS07355 ENOG4106VK6 Flagellar motor protein AL468_RS07375 ENOG4105D9P serine threonine protein kinase AL468_RS07395 ENOG4105F8J Adenylate Guanylate cyclase AL468_RS07410 ENOG4108IG5 Transcriptional regulator AL468_RS07425 ENOG4107QZF nitrite reductase NADPH large subunit AL468_RS07430 ENOG4105D7T ABC transporter AL468_RS07435 ENOG4105DG7 nitrate ABC transporter AL468_RS07465 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL468_RS07480 ENOG4105C44 Serine transporter AL468_RS07490 ENOG4105BZU Histidine kinase AL468_RS07540 ENOG4106E5D Protein of unknown function (DUF461) AL468_RS07545 ENOG4105R8A Heat shock protein AL468_RS07560 ENOG4107RUY (E1 component), alpha subunit AL468_RS07565 ENOG4105CPP Dehydrogenase, E1 component AL468_RS07570 ENOG4107QSN dihydrolipoamide acetyltransferase AL468_RS07575 ENOG4105C10 Electron transfer flavoprotein AL468_RS07580 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL468_RS07615 ENOG4105DMR ABC, transporter AL468_RS07620 ENOG4105GBT ABC transporter AL468_RS07625 ENOG4106PMH Extracellular solute-binding protein family 3 AL468_RS07630 ENOG4105E5Z arginine transporter ATP-binding subunit AL468_RS07670 ENOG4105C26 Dehydrogenase AL468_RS07690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_RS07700 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL468_RS07710 ENOG4105CCU oxidase (Subunit III) AL468_RS07715 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL468_RS07720 ENOG4105E2S oxidase) subunit II AL468_RS07725 ENOG4105CHR reductase AL468_RS07730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL468_RS07735 ENOG4105E39 Enoyl-CoA hydratase AL468_RS07740 ENOG4105E39 Enoyl-CoA hydratase AL468_RS07750 ENOG4105C26 Dehydrogenase AL468_RS07755 ENOG4105CHU acetyl-coa acetyltransferase AL468_RS07765 ENOG4105C1G acyl-Coa dehydrogenase AL468_RS07770 ENOG4107QX3 carboxylase AL468_RS07775 ENOG4105E39 Enoyl-CoA hydratase AL468_RS07780 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL468_RS07795 ENOG4105CQB FAD linked oxidase domain protein AL468_RS07805 ENOG4107U2T alpha beta AL468_RS07810 ENOG4105ECQ AraC Family Transcriptional Regulator AL468_RS07825 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AL468_RS07830 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component AL468_RS07835 ENOG4108IJ8 ABC transporter AL468_RS07840 ENOG4105E90 ABC transporter AL468_RS07845 ENOG4107SDU Methyl-accepting chemotaxis AL468_RS07850 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL468_RS07860 ENOG4105BZU Histidine kinase AL468_RS07865 ENOG4105C1J atp-dependent rna helicase AL468_RS07870 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) AL468_RS07900 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AL468_RS07905 ENOG4105DKW ABC transporter AL468_RS07910 ENOG4105CXC rtn protein AL468_RS07930 ENOG4105C1J atp-dependent rna helicase AL468_RS07935 ENOG4105CKI cobalamin synthesis protein AL468_RS07945 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AL468_RS07955 ENOG4105VEQ Cold shock protein AL468_RS07960 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AL468_RS07965 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL468_RS07975 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AL468_RS07980 ENOG4105C1J atp-dependent rna helicase AL468_RS07990 ENOG4105HF0 Membrane AL468_RS08015 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin AL468_RS08035 ENOG4105VRT cytoplasmic protein AL468_RS08055 ENOG41090A4 Pterin carbinolamine dehydratase AL468_RS08060 ENOG4105MIR Phenylalanine 4-monooxygenase AL468_RS08065 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_RS08070 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL468_RS08095 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AL468_RS08100 ENOG4105C0A alcohol dehydrogenase AL468_RS08115 ENOG4108RMU ferritin dps family protein AL468_RS08120 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS08130 ENOG4107R39 (ABC) transporter AL468_RS08150 ENOG4105BZU Histidine kinase AL468_RS08160 ENOG4105VEQ Cold shock protein AL468_RS08180 ENOG4108ZG0 Ompa motb domain protein AL468_RS08190 ENOG4108V1T peptidylprolyl cis-trans isomerase AL468_RS08195 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL468_RS08200 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AL468_RS08225 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) AL468_RS08230 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL468_RS08250 ENOG4105CCF Lysine exporter protein (Lyse ygga) AL468_RS08255 ENOG4105SUT Transcriptional Regulator AraC Family AL468_RS08270 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AL468_RS08290 ENOG4108SXK Transporter Drug Metabolite Exporter family AL468_RS08295 ENOG4105VW4 glutaredoxin 3 AL468_RS08310 ENOG4105E5M Multidrug resistance protein D AL468_RS08315 ENOG4105CR8 Transcriptional regulator AL468_RS08325 ENOG4105DR5 peptidase AL468_RS08350 ENOG4105DWD nucleoside recognition domain protein AL468_RS08355 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS08365 ENOG4105E0U tyrosine-specific transport protein AL468_RS08385 ENOG4107Z1W Fructose transport system kinase AL468_RS08395 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein AL468_RS08400 ENOG4105CTS PTS system mannitol-specific AL468_RS08405 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia AL468_RS08425 ENOG4105D6J arsenicaL-resistance protein AL468_RS08435 ENOG4108V1U phospholipid-binding protein AL468_RS08440 ENOG4105JAB phenazine biosynthesis protein, phzf family AL468_RS08445 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AL468_RS08455 ENOG4105CJ1 ABC, transporter AL468_RS08460 ENOG4107QWP ABC-2 type transporter AL468_RS08500 ENOG4108IJF Heavy metal efflux pump, CzcA AL468_RS08530 ENOG4108HK0 -acetyltransferase AL468_RS08540 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_RS08550 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL468_RS08565 ENOG4105C5H ABC transporter AL468_RS08570 ENOG4108M6U Universal stress protein A AL468_RS08575 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL468_RS08580 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL468_RS08595 ENOG4105CGF Aromatic amino acid aminotransferase AL468_RS08610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL468_RS08620 ENOG4105C5S asparaginyl-tRNA synthetase AL468_RS08625 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS08630 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AL468_RS08640 ENOG4105BZU Histidine kinase AL468_RS08645 ENOG4105EJQ L-serine dehydratase AL468_RS08650 ENOG4105C44 Serine transporter AL468_RS08655 ENOG4105P8F nudix hydrolase AL468_RS08670 ENOG4105CRQ synthase (Component I) AL468_RS08690 ENOG4105CM6 amino acid regulated cytosolic protein AL468_RS08695 ENOG4106K28 UPF0283 membrane protein AL468_RS08705 ENOG4105D9U N-acetyltransferase AL468_RS08795 ENOG410822N TonB family AL468_RS08915 ENOG410822N TonB family AL468_RS09025 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AL468_RS09215 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL468_RS09435 ENOG4105RHY Pfam:UPF0157 AL468_RS09720 ENOG4108R6K riboflavin synthase, subunit alpha AL468_RS09935 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL468_RS09965 ENOG4105KCV RNA signal recognition particle 4.5S RNA AL468_RS09975 ENOG4105N14 lysine exporter protein LysE YggA AL468_RS09990 ENOG4105Y49 secretion protein, HlyD family AL468_RS10000 ENOG4105EQ2 LysR family Transcriptional regulator AL468_RS10010 ENOG4105Y49 secretion protein, HlyD family AL468_RS10025 ENOG4107V40 secretion protein, HlyD family AL468_RS10040 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AL468_RS10045 ENOG4108V9W transcriptional regulatory protein AL468_RS10050 ENOG4105E0K tonB-dependent siderophore receptor AL468_RS10055 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF AL468_RS10060 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AL468_RS10065 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) AL468_RS10070 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AL468_RS10090 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AL468_RS10095 ENOG4105C26 Dehydrogenase AL468_RS10115 ENOG4108KB1 transcriptional regulator, arac family AL468_RS10145 ENOG41066XE Type III export protein AL468_RS10215 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL468_RS10240 ENOG41062JF Transcriptional regulator AL468_RS10350 ENOG4105H1G trap transporter solute receptor taxi family AL468_RS10355 ENOG4105EJ9 Membrane AL468_RS10390 ENOG4105CR4 methylisocitrate lyase AL468_RS10395 ENOG4105BZN citrate synthase AL468_RS10400 ENOG4108I0Z Aconitate hydratase AL468_RS10405 ENOG4105C7F AcnD-accessory protein PrpF AL468_RS10410 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_RS10420 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AL468_RS10430 ENOG410667J hydrolase AL468_RS10435 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AL468_RS10440 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AL468_RS10445 ENOG4105BZU Histidine kinase AL468_RS10455 ENOG4105CDV Ompa motb domain protein AL468_RS10470 ENOG4105CDV Ompa motb domain protein AL468_RS10485 ENOG4105DR4 Methyltransferase AL468_RS10490 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS10495 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AL468_RS10500 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AL468_RS10510 ENOG4108MN8 Membrane AL468_RS10515 ENOG4105CDA abc transporter atp-binding protein AL468_RS10520 ENOG4105DRP amino acid AbC transporter AL468_RS10525 ENOG4105EZ7 amino acid ABC transporter AL468_RS10530 ENOG4107QXX ABC transporter AL468_RS10545 ENOG4108VPT UPF0234 protein AL468_RS10550 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL468_RS10570 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL468_RS10575 ENOG4105DY2 Paraquat-inducible protein b AL468_RS10580 ENOG4105H2K paraquat-inducible protein a AL468_RS10585 ENOG4105BZ1 (ABC) transporter AL468_RS10590 ENOG4108ZGC gaf domain protein AL468_RS10595 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AL468_RS10600 ENOG4105CN1 protease AL468_RS10610 ENOG4105CD8 aminopeptidase N AL468_RS10620 ENOG4105C7I Dehydrogenase AL468_RS10625 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AL468_RS10630 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AL468_RS10635 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AL468_RS10645 ENOG4105C5H ABC transporter AL468_RS10660 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AL468_RS10665 ENOG4105DAN ATP-dependent protease AL468_RS10670 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) AL468_RS10715 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AL468_RS10730 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) AL468_RS10740 ENOG4105C59 p-type ATPase AL468_RS10755 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL468_RS10760 ENOG4105Q9Y Universal stress protein AL468_RS10765 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AL468_RS10785 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_RS10795 ENOG4105D38 putrescine abc transporter AL468_RS10800 ENOG4108HM4 ABC transporter AL468_RS10805 ENOG4107RUE extracellular solute-binding protein family 1 AL468_RS10810 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AL468_RS10845 ENOG4105QAX Iron-sulfur AL468_RS10850 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL468_RS10860 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL468_RS10880 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL468_RS10885 ENOG4105C5H ABC transporter AL468_RS10895 ENOG4105BZU Histidine kinase AL468_RS10900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS10915 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_RS10920 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AL468_RS10925 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL468_RS10935 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AL468_RS10940 ENOG4106IUH DTW domain containing protein AL468_RS10975 ENOG4107TT5 NLP P60 protein AL468_RS10985 ENOG4105BZU Histidine kinase AL468_RS11005 ENOG4108R6K riboflavin synthase, subunit alpha AL468_RS11010 ENOG4107QI1 Mate efflux family protein AL468_RS11025 ENOG41082AN stage II sporulation protein AL468_RS11035 ENOG4107V1M polysaccharide export protein AL468_RS11050 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS11055 ENOG4107QPH glycogen) synthase AL468_RS11060 ENOG4107TYR Glycosyl Transferase AL468_RS11090 ENOG4105CPK Glycosyl transferase (Group 1 AL468_RS11095 ENOG4107R8N Glycosyl transferase, family 2 AL468_RS11110 ENOG4105C94 Transporter AL468_RS11125 ENOG4105CQ7 ATP-dependent helicase AL468_RS11130 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AL468_RS11175 ENOG4105CFG Acts as a chaperone (By similarity) AL468_RS11180 ENOG4105CFG Acts as a chaperone (By similarity) AL468_RS11200 ENOG4106855 Competence protein AL468_RS11205 ENOG4105BZ1 (ABC) transporter AL468_RS11210 ENOG4105BZ1 (ABC) transporter AL468_RS11220 ENOG4105E0K tonB-dependent siderophore receptor AL468_RS11225 ENOG4105S6R Iron-hydroxamate transporter permease subunit AL468_RS11230 ENOG4105J76 Periplasmic binding protein AL468_RS11235 ENOG4105E0A ABC, transporter AL468_RS11245 ENOG4105CPI Metal Dependent Phosphohydrolase AL468_RS11250 ENOG4105E0U tyrosine-specific transport protein AL468_RS11260 ENOG4105DHT Metal Dependent Phosphohydrolase AL468_RS11270 ENOG4105EE5 Membrane protein terC AL468_RS11280 ENOG41076CZ activating enzyme AL468_RS11285 ENOG4105G0K glycine radical enzyme YjjI family AL468_RS11290 ENOG410829K Lysine exporter protein (Lyse ygga) AL468_RS11295 ENOG4105CPI Metal Dependent Phosphohydrolase AL468_RS11300 ENOG4105BZU Histidine kinase AL468_RS11305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS11315 ENOG4105C8P )-transporter AL468_RS11340 ENOG41090KN UPF0303 protein AL468_RS11345 ENOG4105D9R oxidoreductase AL468_RS11350 ENOG4105E98 transcriptional regulator DeoR family AL468_RS11365 ENOG4105C4X radical SAM domain protein AL468_RS11380 ENOG4105ENH Sulfatase AL468_RS11385 ENOG4105CZK Aspartate kinase AL468_RS11390 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AL468_RS11395 ENOG4108JPW Aminotransferase AL468_RS11400 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase AL468_RS11405 ENOG4105C94 Transporter AL468_RS11420 ENOG4108IJ7 Glycine betaine AL468_RS11425 ENOG4108HQS Glycine betaine AL468_RS11430 ENOG4105GIJ Glycine betaine AL468_RS11465 ENOG4105DHQ Histidine kinase AL468_RS11470 ENOG4105E0M Sulfatase AL468_RS11495 ENOG4105BZG amino acid carrier protein AL468_RS11505 ENOG410829K Lysine exporter protein (Lyse ygga) AL468_RS11510 ENOG4105CTD carboxy-peptidase AL468_RS11515 ENOG4105D1S lipid A biosynthesis AL468_RS11520 ENOG4105E5D amino acid AL468_RS11535 ENOG4105CVG Homoserine O-transsuccinylase AL468_RS11540 ENOG41090FY type IV pilus biogenesis stability protein PilW AL468_RS11550 ENOG4105BZU Histidine kinase AL468_RS11555 ENOG4105BZU Histidine kinase AL468_RS11570 ENOG4108UW5 maltose o-acetyltransferase AL468_RS11585 ENOG4105MSB protein, conserved in bacteria AL468_RS11590 ENOG4108ZT1 Transcriptional regulator AL468_RS11600 ENOG4105BZU Histidine kinase AL468_RS11635 ENOG4108RXX maleylacetoacetate isomerase AL468_RS11645 ENOG4105F1J Homogentisate 1,2-dioxygenase AL468_RS11650 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AL468_RS11655 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL468_RS11660 ENOG4107QSI ABC, transporter AL468_RS11665 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL468_RS11670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_RS11675 ENOG4105C3U ABC transporter AL468_RS11680 ENOG4108JQ7 (ABC) transporter AL468_RS11690 ENOG4107MM9 BNR Asp-box repeat-containing protein AL468_RS11700 ENOG4105D38 putrescine abc transporter AL468_RS11705 ENOG4105F38 ABC transporter, permease AL468_RS11710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_RS11715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL468_RS11720 ENOG4105CIF Ornithine Cyclodeaminase AL468_RS11735 ENOG4105CTU Proline racemase AL468_RS11765 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AL468_RS11770 ENOG4108VKG metal-dependent hydrolase AL468_RS11780 ENOG4105F04 LysR family Transcriptional regulator AL468_RS11800 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AL468_RS11805 ENOG4108IU2 vtamin B12-transporter permease AL468_RS11810 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AL468_RS11830 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AL468_RS11835 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AL468_RS11840 ENOG4105K4T epimerase AL468_RS11845 ENOG4108ETY sodium dicarboxylate symporter AL468_RS11850 ENOG4105CJB Exodeoxyribonuclease I AL468_RS11855 ENOG4105VAW lrga family AL468_RS11860 ENOG41067MG lrgb family AL468_RS11865 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) AL468_RS11870 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AL468_RS11875 ENOG4105FQ6 thiopurine methyltransferase AL468_RS11885 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL468_RS11895 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AL468_RS11900 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AL468_RS11930 ENOG4105K8R UPF0145 protein AL468_RS11935 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AL468_RS11940 ENOG41082NX 50s ribosomal protein l35 AL468_RS11945 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AL468_RS11950 ENOG4105C22 threonyL-tRNA synthetase AL468_RS11965 ENOG4105CZE histidine utilization repressor AL468_RS11970 ENOG4105CI2 imidazolone-5-propionate hydrolase AL468_RS11975 ENOG41088SP formiminoglutamate hydrolase AL468_RS11985 ENOG4105C84 Histidine ammonia-lyase AL468_RS12000 ENOG4105CQB FAD linked oxidase domain protein AL468_RS12015 ENOG4105CDV Ompa motb domain protein AL468_RS12035 ENOG4105C8V SAICAR synthetase AL468_RS12050 ENOG4105CQ7 ATP-dependent helicase AL468_RS12055 ENOG4107R1I NAD-dependent malic enzyme AL468_RS12060 ENOG4107GZ4 SanA protein AL468_RS12065 ENOG4105C8P )-transporter AL468_RS12090 ENOG4105C3M thioredoxin reductase AL468_RS12095 ENOG4108JJ9 ABC, transporter AL468_RS12100 ENOG4108JJ8 (ABC) transporter AL468_RS12105 ENOG4105BZC d-serine deaminase AL468_RS12110 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AL468_RS12120 ENOG4105BZU Histidine kinase AL468_RS12150 ENOG4105DWU Membrane AL468_RS12160 ENOG4105DY8 decarboxylase AL468_RS12165 ENOG4106KNT transcriptional regulator AL468_RS12180 ENOG41090BQ Glutaredoxin AL468_RS12185 ENOG4105D0C transport protein AL468_RS12190 ENOG4105RKW reductase (By AL468_RS12195 ENOG4107QPN acyl-Coa dehydrogenase AL468_RS12200 ENOG41067SE Tetr family transcriptional regulator AL468_RS12210 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AL468_RS12230 ENOG4107QI1 Mate efflux family protein AL468_RS12235 ENOG4105CGD Nad-dependent epimerase dehydratase AL468_RS12240 ENOG4105CUW cytochrome C-TYPE protein AL468_RS12270 ENOG4105C2C drug resistance transporter, Bcr CflA AL468_RS12280 ENOG4105I08 Pseudouridine synthase AL468_RS12285 ENOG4105CFI type iii restriction protein res subunit AL468_RS12295 ENOG4105ETX regulatoR AL468_RS12300 ENOG4105EB3 Histidine kinase AL468_RS12310 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AL468_RS12320 ENOG4105CGH 5'-nucleotidase AL468_RS12330 ENOG4105XZD Fe-S protein AL468_RS12340 ENOG4105VNH ABC transporter solute-binding protein AL468_RS12345 ENOG4105CXZ ABC transporter, permease AL468_RS12350 ENOG4108VGW abc transporter atp-binding protein AL468_RS12355 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AL468_RS12370 ENOG4108JUA Transcriptional regulator AL468_RS12375 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AL468_RS12380 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL468_RS12390 ENOG4108W1A pseudouridine synthase AL468_RS12395 ENOG4105C8J )-transporter AL468_RS12400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AL468_RS12405 ENOG4105C28 cystathionine AL468_RS12410 ENOG4107IFA Lipase (EC 3.1.1.3) AL468_RS12420 ENOG4108R3E Dna-3-methyladenine glycosylase i AL468_RS12440 ENOG4105FM1 phage shock protein C AL468_RS12445 ENOG4105YYT phage shock protein B AL468_RS12450 ENOG41087YS Phage shock protein A AL468_RS12455 ENOG4105E51 psp operon transcriptional activator AL468_RS12460 ENOG4108J59 Extracellular solute-binding protein, family 5 AL468_RS12465 ENOG4108EKA peptide transport system, permease AL468_RS12470 ENOG4108EU3 peptide transport system, permease AL468_RS12475 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AL468_RS12480 ENOG4108JQ2 peptide transport system atp-binding protein AL468_RS12490 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AL468_RS12505 ENOG4108J2R molybdopterin oxidoreductase AL468_RS12530 ENOG4105TMB Formate nitrite transporter AL468_RS12555 ENOG4107DB1 DUF218 domain AL468_RS12560 ENOG4107104 thymidine kinase AL468_RS12565 ENOG4105C8N cysteinyl-tRNA synthetase AL468_RS12570 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL468_RS12575 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AL468_RS12580 ENOG4105D58 Diguanylate phosphodiesterase AL468_RS12585 ENOG4105K5B UPF0225 protein AL468_RS12595 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AL468_RS12610 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AL468_RS12615 ENOG4105CIH Imidazole acetol-phosphate transaminase AL468_RS12620 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AL468_RS12625 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AL468_RS12630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS12635 ENOG4107S6Z Na H antiporter AL468_RS12640 ENOG4108YX2 DNA-binding protein AL468_RS12645 ENOG4107RE1 Inosine-guanosine kinase AL468_RS12655 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AL468_RS12660 ENOG41075W9 High frequency lysogenization protein HflD homolog AL468_RS12665 ENOG4107QTF adenylosuccinate lyase AL468_RS12675 ENOG4105RHG AL468_RS12685 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AL468_RS12700 ENOG4107FW0 short-chain dehydrogenase reductase AL468_RS12710 ENOG4105D0M Protease HtpX homolog AL468_RS12720 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AL468_RS12730 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL468_RS12735 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AL468_RS12755 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AL468_RS12760 ENOG4105D1H recombination factor protein RarA AL468_RS12765 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AL468_RS12770 ENOG4105CNU cell division protein FtsK AL468_RS12775 ENOG4105EW9 transcriptional regulator AsnC family AL468_RS12780 ENOG4105DCF alanine dehydrogenase AL468_RS12790 ENOG4107R11 Transcriptional regulator AL468_RS12800 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AL468_RS12805 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS12840 ENOG4105BZS acriflavin resistance protein AL468_RS12845 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL468_RS12850 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS12860 ENOG4108RNS Exports L-alanine (By similarity) AL468_RS12865 ENOG4105BZU Histidine kinase AL468_RS12875 ENOG4106032 Glutathionylspermidine synthase AL468_RS12885 ENOG4105Z6B inner membrane protein yjfl AL468_RS12895 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AL468_RS12900 ENOG4105UFD tol-pal system protein YbgF AL468_RS12905 ENOG4105KCK Peptidoglycan-associated lipoprotein AL468_RS12910 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AL468_RS12920 ENOG4105M8F Biopolymer transport protein exbD tolR AL468_RS12925 ENOG4105E02 MotA TolQ exbB proton channel AL468_RS12930 ENOG4107YD3 Thioesterase AL468_RS12945 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL468_RS12950 ENOG4105C4M (Ubiquinol oxidase) subunit I AL468_RS12955 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AL468_RS12960 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AL468_RS12965 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AL468_RS12970 ENOG4105CDY transcriptional regulatory protein AL468_RS12975 ENOG4105C9M aspartyl-trna synthetase AL468_RS12980 ENOG41081XQ Conserved Protein AL468_RS12985 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AL468_RS12990 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AL468_RS13000 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AL468_RS13020 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AL468_RS13025 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AL468_RS13030 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) AL468_RS13035 ENOG4106371 Methyltransferase AL468_RS13040 ENOG4107S90 membrAne AL468_RS13045 ENOG4106WF9 DNA-binding transcriptional regulator TorR AL468_RS13050 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL468_RS13055 ENOG4105ETE Transcriptional regulator (LacI family AL468_RS13060 ENOG4105HP8 regulator of competence-specific genes AL468_RS13080 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AL468_RS13085 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AL468_RS13090 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL468_RS13095 ENOG4105RKX Protein of unknown function (DUF2498) AL468_RS13100 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AL468_RS13110 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AL468_RS13115 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AL468_RS13120 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AL468_RS13125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_RS13130 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AL468_RS13135 ENOG4105VEQ Cold shock protein AL468_RS13145 ENOG4108R99 pseudouridine synthase AL468_RS13155 ENOG4105SDR Outer membrane protein OmpT AL468_RS13160 ENOG4105DVT helicase AL468_RS13165 ENOG4105EJ9 Membrane AL468_RS13170 ENOG4108URS primosomal replication protein n'' AL468_RS13175 ENOG4106428 Protein of unknown function (DUF2496) AL468_RS13180 ENOG4105CGK Exodeoxyribonuclease III AL468_RS13195 ENOG4105DSP amino acid AbC transporter AL468_RS13200 ENOG4105E89 ABC transporter AL468_RS13205 ENOG4108JEH abc transporter atp-binding protein AL468_RS13225 ENOG4105C6N Formate acetyltransferase AL468_RS13235 ENOG4105F1A Pyruvate formate-lyase AL468_RS13245 ENOG4105XWI UPF0304 protein AL468_RS13255 ENOG4105CYN Serine protein kinase AL468_RS13260 ENOG4106AKX UPF0229 protein AL468_RS13265 ENOG4105ED1 spovr family AL468_RS13270 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AL468_RS13275 ENOG4105W49 UPF0434 protein AL468_RS13280 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AL468_RS13285 ENOG4105BZ1 (ABC) transporter AL468_RS13290 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AL468_RS13300 ENOG4105D60 lipoprotein releasing system transmembrane protein AL468_RS13305 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AL468_RS13310 ENOG4105D60 lipoprotein releasing system transmembrane protein AL468_RS13320 ENOG4108JA2 transcriptioN-repair coupling factor AL468_RS13335 ENOG4105CEP NADH dehydrogenase AL468_RS13340 ENOG4105D0Y UPF0227 protein AL468_RS13365 ENOG4105K59 histidine triad (HIT) protein AL468_RS13370 ENOG4108NVR Methyl-accepting chemotaxis AL468_RS13380 ENOG4107SXA Phosphorylase AL468_RS13390 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL468_RS13420 ENOG4108MNP Glycoprotein polysaccharide metabolism AL468_RS13425 ENOG4105C29 acyl-CoA thioesterase AL468_RS13435 ENOG4108XM1 transcriptional regulator AsnC family AL468_RS13460 ENOG4105BZS acriflavin resistance protein AL468_RS13465 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AL468_RS13510 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL468_RS13515 ENOG4105HMI Membrane AL468_RS13525 ENOG4105CEY Amp-dependent synthetase and ligase AL468_RS13535 ENOG4108IPT Naphthoate synthase AL468_RS13540 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AL468_RS13545 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AL468_RS13550 ENOG4105E4F Isochorismate synthase AL468_RS13555 ENOG4105CHM Aminotransferase AL468_RS13560 ENOG4105DK2 UPF0207 protein AL468_RS13565 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AL468_RS13580 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AL468_RS13585 ENOG4105EIN peptidylprolyl cis-trans isomerase AL468_RS13590 ENOG4105K70 DNA-binding protein AL468_RS13595 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AL468_RS13600 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AL468_RS13605 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AL468_RS13610 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AL468_RS13620 ENOG4105CQZ Histidine kinase AL468_RS13625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS13635 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL468_RS13640 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ AL468_RS13645 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL468_RS13650 ENOG4105CNG UPF0061 protein AL468_RS13670 ENOG4107ZYR domain protein AL468_RS13675 ENOG4105C1J atp-dependent rna helicase AL468_RS13715 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL468_RS13730 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_RS13735 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL468_RS13740 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AL468_RS13745 ENOG4105C84 Histidine ammonia-lyase AL468_RS13770 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_RS13780 ENOG4105C2D reductase AL468_RS13785 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_RS13850 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AL468_RS13855 ENOG4105D9N nucleoside AL468_RS13865 ENOG4105CVE Lytic murein transglycosylase AL468_RS13870 ENOG4105VNG YcgL domain-containing protein AL468_RS13875 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AL468_RS13880 ENOG4107QMS site-determining protein AL468_RS13885 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AL468_RS13890 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AL468_RS13895 ENOG4105CEY Amp-dependent synthetase and ligase AL468_RS13900 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_RS13905 ENOG4105R8X Outer membrane lipoprotein Slp AL468_RS13915 ENOG41072GX Peptidase M22 Glycoprotease AL468_RS13920 ENOG4105DVT helicase AL468_RS13925 ENOG4105CIY formyltetrahydrofolate deformylase AL468_RS13930 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap AL468_RS13940 ENOG4106ZCM YecM protein AL468_RS13950 ENOG4105C75 arginyL-tRNA synthetase AL468_RS13965 ENOG4105CE1 Ferrous iron transport protein b AL468_RS13970 ENOG4105XFK Ferrous iron transport protein A AL468_RS13975 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AL468_RS13980 ENOG4105NXV High-affinity zinc uptake system protein AL468_RS13985 ENOG4105FDK ABC transporter AL468_RS13990 ENOG4105FAV ABC, transporter AL468_RS13995 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AL468_RS14000 ENOG4105CMV Succinyl-CoA synthetase subunit beta AL468_RS14005 ENOG4105C7S Dehydrogenase AL468_RS14010 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AL468_RS14015 ENOG4105E33 succinate dehydrogenase AL468_RS14020 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AL468_RS14025 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AL468_RS14030 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AL468_RS14035 ENOG4105BZN citrate synthase AL468_RS14040 ENOG4107QNR UPF0135 protein AL468_RS14050 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AL468_RS14055 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AL468_RS14060 ENOG4105EV9 Alpha Beta Hydrolase AL468_RS14070 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AL468_RS14080 ENOG41090R7 Ferric uptake AL468_RS14085 ENOG4105CX6 glutaminyL-tRNA synthetase AL468_RS14090 ENOG4105CI1 PTS System AL468_RS14100 ENOG4105CE4 GlcNAc 6-P deacetylase AL468_RS14105 ENOG4105E2R ROK family AL468_RS14110 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL468_RS14115 ENOG4105CAQ asparagine synthetase AL468_RS14120 ENOG4105MDZ Transcriptional activator rfaH AL468_RS14125 ENOG4105DUX Transporter AL468_RS14130 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AL468_RS14135 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AL468_RS14140 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AL468_RS14145 ENOG4108DQ1 activator toxR AL468_RS14165 ENOG4108RE9 Phosphodiesterase AL468_RS14195 ENOG4105ECP epimerase AL468_RS14200 ENOG4105E1F short-chain dehydrogenase reductase AL468_RS14210 ENOG4107QR8 Thioredoxin AL468_RS14215 ENOG4107QX8 SPFH domain, Band 7 family protein AL468_RS14240 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AL468_RS14245 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AL468_RS14250 ENOG4105EXN Sulfate transport protein CysZ AL468_RS14255 ENOG4105C6T cysteine synthase AL468_RS14265 ENOG4105KZ7 phosphocarrier protein hpr AL468_RS14270 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AL468_RS14275 ENOG4105C5Y PTS System AL468_RS14285 ENOG4105I03 Flagellin AL468_RS14295 ENOG4105I03 Flagellin AL468_RS14300 ENOG4105DTJ flagellar hook-associated protein AL468_RS14310 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL468_RS14315 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_RS14320 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL468_RS14325 ENOG4105CGA flagellar basal-body rod protein FlgG AL468_RS14330 ENOG4108KPB Flagellar basal-body rod protein FlgF AL468_RS14335 ENOG4105BZE flagellar hook protein, FlgE AL468_RS14340 ENOG4105W00 Flagellar hook capping protein AL468_RS14345 ENOG4108ZC9 flagellar basal-body rod protein flgc AL468_RS14350 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL468_RS14355 ENOG4105BZU Histidine kinase AL468_RS14360 ENOG4107R88 Chemotaxis protein (CheV) AL468_RS14405 ENOG4105UYK outer membrane protein a AL468_RS14410 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AL468_RS14420 ENOG41081QG Porin Gram-negative type AL468_RS14435 ENOG4105C59 p-type ATPase AL468_RS14450 ENOG4105E2D ec 3.2.1.52 AL468_RS14475 ENOG4108DG9 Smr protein MutS2 AL468_RS14480 ENOG4105FE9 pseudouridine synthase AL468_RS14485 ENOG4108Z66 YbaK ebsC protein AL468_RS14490 ENOG4105CGH 5'-nucleotidase AL468_RS14495 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AL468_RS14500 ENOG41063JG Transcriptional regulator AL468_RS14505 ENOG4108YY7 Invasion gene expression up-regulator SirB AL468_RS14510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AL468_RS14515 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AL468_RS14520 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AL468_RS14525 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AL468_RS14530 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AL468_RS14535 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AL468_RS14540 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AL468_RS14545 ENOG4105C3G gtp-binding protein AL468_RS14655 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL468_RS14665 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AL468_RS14670 ENOG4105C9A Phoh family AL468_RS14675 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AL468_RS14680 ENOG4108JU5 Magnesium and cobalt efflux protein AL468_RS14685 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AL468_RS14690 ENOG4107PAI alpha helical protein AL468_RS14695 ENOG4105C8T Leucyl-tRNA synthetase AL468_RS14700 ENOG4108U2H Rare lipoprotein B AL468_RS14705 ENOG4105DJF DNA polymerase III, delta' subunit AL468_RS14710 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AL468_RS14715 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AL468_RS14720 ENOG4105CJN penicillin-binding protein AL468_RS14725 ENOG4105CNI cell division protein FtsW AL468_RS14730 ENOG4105K6T rare lipoprotein A AL468_RS14735 ENOG4105DZ1 carboxypeptidase AL468_RS14740 ENOG4108Z43 UPF0250 protein AL468_RS14745 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AL468_RS14750 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AL468_RS14755 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL468_RS14760 ENOG4108JYZ YitT family AL468_RS14775 ENOG4105CG3 alpha amylase, catalytic region AL468_RS14780 ENOG4105C5Y PTS System AL468_RS14785 ENOG4105D4X repressor AL468_RS14790 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AL468_RS14795 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AL468_RS14800 ENOG4108UMI ABC transporter, permease AL468_RS14805 ENOG4105D01 (LipO)protein AL468_RS14810 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein AL468_RS14815 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AL468_RS14820 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AL468_RS14835 ENOG4105EWT decarboxylase family AL468_RS14840 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease AL468_RS14845 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AL468_RS14850 ENOG4105M08 Membrane AL468_RS14860 ENOG4105ETT transcriptional Regulator, LysR family AL468_RS14865 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AL468_RS14870 ENOG4106VK6 Flagellar motor protein AL468_RS14875 ENOG4105E14 MotA TolQ exbB proton channel AL468_RS14880 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL468_RS14885 ENOG4105CTB Polyprenyl synthetase AL468_RS14890 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AL468_RS14895 ENOG4108ZAI phosphatidylglycerophosphatase a AL468_RS14900 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AL468_RS14905 ENOG4107YIM Involved in the transcription termination process (By similarity) AL468_RS14925 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL468_RS14930 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AL468_RS14935 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AL468_RS14940 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AL468_RS14945 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AL468_RS14950 ENOG4108DJV Fermentation respiration switch protein AL468_RS14955 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AL468_RS14965 ENOG4105C7N Xanthine uracil vitamin C permease AL468_RS14970 ENOG4105CIN aminoacyl-histidine dipeptidase AL468_RS14985 ENOG4105X58 receptor AL468_RS15000 ENOG4108ETH Formylglycinamide ribotide synthetase AL468_RS15005 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AL468_RS15015 ENOG4108Z6B deaminase AL468_RS15020 ENOG4105CFC Transporter AL468_RS15055 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AL468_RS15065 ENOG4105CK2 sodium dicarboxylate symporter AL468_RS15070 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AL468_RS15075 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AL468_RS15085 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AL468_RS15090 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL468_RS15095 ENOG4105VDB UPF0125 protein AL468_RS15100 ENOG4108Z1B Cyclase dehydrase AL468_RS15105 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AL468_RS15120 ENOG4105ETT transcriptional Regulator, LysR family AL468_RS15125 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AL468_RS15145 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL468_RS15150 ENOG4108IQK o-acetylhomoserine AL468_RS15170 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL468_RS15175 ENOG4105BZG amino acid carrier protein AL468_RS15180 ENOG4106HK8 GPR1 FUN34 yaaH family protein AL468_RS15190 ENOG4107S6Z Na H antiporter AL468_RS15270 ENOG4105DFP Integrase AL468_RS15275 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL468_RS15280 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL468_RS15285 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL468_RS15300 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AL468_RS15305 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL468_RS15310 ENOG4105N21 Membrane AL468_RS15315 ENOG4105CUT histidyl-tRNA synthetase AL468_RS15320 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AL468_RS15335 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AL468_RS15340 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AL468_RS15345 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AL468_RS15350 ENOG4105WVQ Fe-S assembly protein IscX AL468_RS15355 ENOG4108ZIT Ferredoxin, 2FE-2S AL468_RS15360 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AL468_RS15365 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AL468_RS15370 ENOG4108Z4V iron-sulfur cluster assembly AL468_RS15375 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AL468_RS15380 ENOG4105C3J Cysteine desulfurase AL468_RS15385 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AL468_RS15390 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AL468_RS15395 ENOG4105ECY inositol monophosphatase AL468_RS15400 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_RS15405 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL468_RS15410 ENOG4105VIE preprotein translocase, subunit YajC AL468_RS15415 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AL468_RS15420 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AL468_RS15435 ENOG4105W87 Cbs domain AL468_RS15440 ENOG4108I9X Isocitrate lyase AL468_RS15445 ENOG4107QP3 malate synthase g AL468_RS15450 ENOG4105C5Q Transcriptional regulator AL468_RS15455 ENOG4105D3R alkyl hydroperoxide reductase AL468_RS15460 ENOG4106N3A copper homeostasis protein cutc AL468_RS15465 ENOG4105CSR polyphosphate kinase 2 AL468_RS15475 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL468_RS15480 ENOG4105E2Z phosphate ABC transporter (Permease AL468_RS15485 ENOG4105C8U phosphate abc transporter AL468_RS15490 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AL468_RS15495 ENOG4105C9X ppx gppa phosphatase AL468_RS15500 ENOG4105DJH phosphate AL468_RS15505 ENOG4105BZU Histidine kinase AL468_RS15510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL468_RS15520 ENOG4105DH7 May be involved in recombination (By similarity) AL468_RS15525 ENOG4105CFP Peptidase U32 AL468_RS15530 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AL468_RS15590 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL468_RS15595 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AL468_RS15600 ENOG4105C34 Pseudouridine synthase AL468_RS15605 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL468_RS15610 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AL468_RS15615 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AL468_RS15625 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL468_RS15630 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) AL468_RS15635 ENOG4107SC1 transglycosylase AL468_RS15640 ENOG4105C5H ABC transporter AL468_RS15650 ENOG4105E4C Lytic transglycosylase catalytic AL468_RS15655 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AL468_RS15660 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL468_RS15665 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AL468_RS15670 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AL468_RS15675 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AL468_RS15695 ENOG4108HRK Histidine kinase AL468_RS15700 ENOG4108NEV two component transcriptional regulator, LytTR family AL468_RS15710 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AL468_RS15715 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AL468_RS15720 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AL468_RS15725 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL468_RS15730 ENOG4105DTN riboflavin biosynthesis protein ribF AL468_RS15735 ENOG4105CJR Integral membrane protein (MviN AL468_RS15740 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AL468_RS15745 ENOG41080HT Transcriptional regulator, arsr family AL468_RS15750 ENOG41063Z6 transcriptional regulator, lysR family AL468_RS15765 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AL468_RS15770 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AL468_RS15775 ENOG4105HF0 Membrane AL468_RS15780 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AL468_RS15785 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AL468_RS15790 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) AL468_RS15800 ENOG4105CPC Aldo Keto reductase AL468_RS15810 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS15815 ENOG4105CRK lysyL-tRNA synthetase AL468_RS15825 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AL468_RS15830 ENOG4105T95 Thiol disulfide interChange protein AL468_RS15840 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AL468_RS15845 ENOG4105CWM branched-chain amino acid transport system II carrier protein AL468_RS15850 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AL468_RS15855 ENOG4105C1J atp-dependent rna helicase AL468_RS15860 ENOG4105D1Q UPF0246 protein AL468_RS15865 ENOG4105BZG amino acid carrier protein AL468_RS15880 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AL468_RS15890 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AL468_RS15895 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) AL468_RS15905 ENOG4105D98 threonine synthase AL468_RS15910 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AL468_RS15930 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL468_RS15945 ENOG41065U4 response regulator AL468_RS15955 ENOG4105BZU Histidine kinase AL468_RS15965 ENOG4105N5T Radical SAM Protein AL468_RS15985 ENOG4105BZ8 glutamate synthase AL468_RS15995 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AL468_RS16000 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AL468_RS16005 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AL468_RS16010 ENOG4105EN6 Membrane AL468_RS16015 ENOG4105VP0 transcriptional regulator, lysR family AL468_RS16030 ENOG4105EJ9 Membrane AL468_RS16050 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AL468_RS16055 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AL468_RS16060 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AL468_RS16065 ENOG4105M6F mutator MutT protein AL468_RS16070 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL468_RS16080 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_RS16085 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AL468_RS16090 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AL468_RS16095 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AL468_RS16100 ENOG4105DFU Cell wall formation (By similarity) AL468_RS16105 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AL468_RS16115 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AL468_RS16120 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AL468_RS16125 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AL468_RS16130 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AL468_RS16135 ENOG4105CJN penicillin-binding protein AL468_RS16140 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL468_RS16145 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AL468_RS16155 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AL468_RS16165 ENOG41082RQ UPF0102 protein AL468_RS16170 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL468_RS16175 ENOG4105W4M Transport-associated protein AL468_RS16180 ENOG4105KB2 stringent starvation protein b AL468_RS16185 ENOG4107MKT Stringent starvation protein a AL468_RS16190 ENOG4105EIX cytochrome c1 AL468_RS16195 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL468_RS16200 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL468_RS16205 ENOG4108UJD 30S ribosomal protein S9 AL468_RS16210 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AL468_RS16220 ENOG4105D6Z AFG1 family ATPase AL468_RS16230 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AL468_RS16235 ENOG4105C0H protease AL468_RS16240 ENOG4105C0H protease AL468_RS16245 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_RS16250 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_RS16255 ENOG4105IPS esterase AL468_RS16260 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AL468_RS16265 ENOG4108SX3 cytoplasmic protein AL468_RS16270 ENOG41087AY ADP-Ribose pyrophosphatase AL468_RS16275 ENOG4105DFG type I secretion outer membrane protein AL468_RS16280 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AL468_RS16285 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AL468_RS16290 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS16300 ENOG4105I7R Adenylate cyclase AL468_RS16305 ENOG4107IX6 phosphate transport regulator AL468_RS16310 ENOG4105CJ3 phosphate transporter AL468_RS16315 ENOG4106MWK domain protein AL468_RS16320 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL468_RS16335 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AL468_RS16340 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AL468_RS16345 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL468_RS16350 ENOG4107ZVW dihydroneopterin aldolase AL468_RS16355 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AL468_RS16360 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AL468_RS16365 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL468_RS16370 ENOG4105VCC 30S ribosomal protein S21 AL468_RS16375 ENOG4105KTH gatB Yqey AL468_RS16380 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AL468_RS16385 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_RS16395 ENOG4105D01 (LipO)protein AL468_RS16430 ENOG4105CTS PTS system mannitol-specific AL468_RS16435 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AL468_RS16440 ENOG4105E61 Mannitol repressor protein AL468_RS16455 ENOG4108UTZ Dihydroxyacetone kinase AL468_RS16460 ENOG4105CMT Dihydroxyacetone kinase AL468_RS16470 ENOG4105GR3 Histidine kinase AL468_RS16485 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AL468_RS16490 ENOG410804X Transcriptional regulator AL468_RS16500 ENOG4105CA9 Pyruvate kinase AL468_RS16510 ENOG4105BZU Histidine kinase AL468_RS16515 ENOG4108ZP8 Acetolactate synthase small subunit AL468_RS16520 ENOG4105C7K acetolactate synthase AL468_RS16525 ENOG4108IQE Amp-dependent synthetase and ligase AL468_RS16530 ENOG41064T2 transcriptional regulator, lysR family AL468_RS16555 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AL468_RS16560 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AL468_RS16565 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL468_RS16570 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL468_RS16580 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AL468_RS16585 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AL468_RS16590 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AL468_RS16595 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AL468_RS16600 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AL468_RS16605 ENOG4105NWN ApaG protein AL468_RS16610 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AL468_RS16625 ENOG4105DWK Membrane AL468_RS16630 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AL468_RS16635 ENOG4105K46 50S ribosomal protein l27 AL468_RS16640 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AL468_RS16645 ENOG4105EAH synthase AL468_RS16655 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AL468_RS16660 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AL468_RS16670 ENOG4105H1G trap transporter solute receptor taxi family AL468_RS16690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_RS16695 ENOG4105CC0 LysR family Transcriptional regulator AL468_RS16700 ENOG4107T0D ABC, transporter AL468_RS16705 ENOG4106SMU thiamine transporter membrane protein AL468_RS16710 ENOG4105DP9 ABC transporter AL468_RS16715 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AL468_RS16720 ENOG4105DFU Cell wall formation (By similarity) AL468_RS16730 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AL468_RS16735 ENOG4105F0N pyrophosphate phospho-hydrolase AL468_RS16745 ENOG41066HZ AIG2-like family AL468_RS16750 ENOG4105MA0 exported protein AL468_RS16755 ENOG4105CFU surface antigen AL468_RS16760 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL468_RS16765 ENOG41061GZ Protein of unknown function (DUF1107) AL468_RS16770 ENOG4108UUE Transcriptional regulator AL468_RS16785 ENOG4108I0Y (ABC) transporter AL468_RS16805 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AL468_RS16815 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AL468_RS16820 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AL468_RS16825 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL468_RS16830 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AL468_RS16840 ENOG4105C1J atp-dependent rna helicase AL468_RS16845 ENOG4107YB6 acetyltransferase, (GNAT) family AL468_RS16855 ENOG4108V1T peptidylprolyl cis-trans isomerase AL468_RS16865 ENOG4108ZT0 50S ribosomal protein l17 AL468_RS16870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL468_RS16875 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AL468_RS16880 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AL468_RS16885 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AL468_RS16895 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AL468_RS16900 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AL468_RS16905 ENOG4105VPB 50S ribosomal protein L30 AL468_RS16910 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AL468_RS16920 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AL468_RS16925 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AL468_RS16930 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AL468_RS16935 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AL468_RS16940 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AL468_RS16945 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AL468_RS16950 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AL468_RS16955 ENOG41083MP 50s ribosomal protein l29 AL468_RS16960 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AL468_RS16965 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AL468_RS16970 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AL468_RS16975 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AL468_RS16980 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AL468_RS16985 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AL468_RS16990 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AL468_RS16995 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AL468_RS17000 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AL468_RS17005 ENOG4105VFB Binds the 23S rRNA (By similarity) AL468_RS17015 ENOG4105C25 Primosomal protein n' AL468_RS17020 ENOG4105ETE Transcriptional regulator (LacI family AL468_RS17030 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AL468_RS17035 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AL468_RS17040 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AL468_RS17045 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AL468_RS17050 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AL468_RS17060 ENOG4105CBT Fructose-1,6-bisphosphatase AL468_RS17090 ENOG4105CP7 Triose-phosphate isomerase AL468_RS17095 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AL468_RS17115 ENOG4108RYC glycosyltransferase AL468_RS17130 ENOG41090RK glycosyl transferase AL468_RS17150 ENOG4105ESV Glycosyl transferase, family 4 AL468_RS17200 ENOG4105DAY polysaccharide export protein AL468_RS17215 ENOG4108MDC (LipO)protein AL468_RS17225 ENOG4105E3R (LipO)protein AL468_RS17230 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AL468_RS17235 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AL468_RS17245 ENOG4105XA0 heptosyltransferase ii AL468_RS17250 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AL468_RS17255 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) AL468_RS17295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AL468_RS17300 ENOG4105C1B dTDP-glucose 4-6-dehydratase AL468_RS17305 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) AL468_RS17310 ENOG41080IJ Diacylglycerol kinase AL468_RS17315 ENOG4105DKP glycosyl transferase, family 9 AL468_RS17320 ENOG4106WTF Glycosyl transferase, family 2 AL468_RS17330 ENOG4108JMC lipopolysaccharide core biosynthesis protein AL468_RS17335 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AL468_RS17340 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AL468_RS17355 ENOG4105KDC 50s ribosomal protein l28 AL468_RS17360 ENOG4105W5Q DNA repair protein (RadC AL468_RS17365 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS17375 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AL468_RS17380 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AL468_RS17385 ENOG4105D1S lipid A biosynthesis AL468_RS17390 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AL468_RS17395 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AL468_RS17405 ENOG4105DSJ YicC domain protein AL468_RS17415 ENOG4105DFD Na H antiporter AL468_RS17420 ENOG4105CIF Ornithine Cyclodeaminase AL468_RS17440 ENOG4108JQ7 (ABC) transporter AL468_RS17450 ENOG4107QRA Extracellular solute-binding protein, family 5 AL468_RS17455 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AL468_RS17460 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AL468_RS17490 ENOG4109015 Biopolymer transport protein exbD tolR AL468_RS17505 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AL468_RS17510 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AL468_RS17515 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL468_RS17520 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AL468_RS17525 ENOG4105CB5 ATP-dependent DNA helicase recG AL468_RS17530 ENOG4105C2W permease AL468_RS17535 ENOG4105E0F Histidine kinase AL468_RS17550 ENOG4108RRZ Transcription elongation factor GreB AL468_RS17560 ENOG4105BZM domain protein AL468_RS17570 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL468_RS17575 ENOG4105MJ2 Competence protein AL468_RS17580 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AL468_RS17585 ENOG4107RK2 ADP-ribose diphosphatase NudE AL468_RS17595 ENOG4105PIC general secretion pathway protein N AL468_RS17600 ENOG4105U1E general secretion pathway protein M AL468_RS17605 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) AL468_RS17610 ENOG4108RTD type II secretion system protein K AL468_RS17615 ENOG4108WWZ General secretion pathway protein J AL468_RS17620 ENOG4105X5Z General secretion pathway protein I AL468_RS17625 ENOG4105VWV general secretion pathway protein h AL468_RS17630 ENOG4108VAU general secretion pathway protein G AL468_RS17635 ENOG4105D7Q type ii secretion system AL468_RS17640 ENOG4107QHF type ii secretion system protein e AL468_RS17650 ENOG4108XKW General secretion pathway protein C AL468_RS17655 ENOG4105VEJ Heat shock protein AL468_RS17660 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AL468_RS17665 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AL468_RS17675 ENOG4105SUU thioesterase domain AL468_RS17680 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AL468_RS17685 ENOG4107S2Z UPF0761 membrane protein AL468_RS17705 ENOG4105CI3 gtp-binding protein typa AL468_RS17710 ENOG4105C5F glutamine synthetase AL468_RS17720 ENOG4105CUX Signal transduction histidine kinase AL468_RS17725 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS17730 ENOG4105BZU Histidine kinase AL468_RS17735 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL468_RS17740 ENOG4105D4P Coproporphyrinogen iii oxidase AL468_RS17745 ENOG4105XCT Protein of unknown function (DUF2489) AL468_RS17750 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AL468_RS17765 ENOG4106RE7 Cytochrome AL468_RS17770 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AL468_RS17775 ENOG4105C2M dna polymerase I AL468_RS17785 ENOG4105KD7 acetyltransferase AL468_RS17790 ENOG4105D52 delta-aminolevulinic acid dehydratase AL468_RS17800 ENOG4105F8V Hydrolase, tatD family AL468_RS17810 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AL468_RS17820 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AL468_RS17825 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL468_RS17830 ENOG4105JC1 sterol-binding domain protein AL468_RS17835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AL468_RS17840 ENOG4105CGY Dna recombination protein AL468_RS17850 ENOG4105BZU Histidine kinase AL468_RS17855 ENOG4105DSF transport protein AL468_RS17890 ENOG4107TE5 Lipid kinase AL468_RS17915 ENOG4108JUA Transcriptional regulator AL468_RS17920 ENOG4105CBX hi0933 family AL468_RS17925 ENOG4108V6B universal stress protein B AL468_RS17930 ENOG41090A1 ferritin AL468_RS17935 ENOG4108M6U Universal stress protein A AL468_RS17940 ENOG4105EMK carboxylate amino acid amine transporter AL468_RS17950 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AL468_RS17955 ENOG4105BZU Histidine kinase AL468_RS17960 ENOG4108VVK transcriptional Regulator, AsnC AL468_RS17965 ENOG4105DGW oligopeptidase A AL468_RS17970 ENOG4105D6S protein involved in catabolism of external DNA AL468_RS17975 ENOG4105DC8 reductase AL468_RS17980 ENOG4107RSM transcriptional regulator AL468_RS17985 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AL468_RS17990 ENOG4108UHU Aldolase AL468_RS17995 ENOG4105C6Z Gluconate AL468_RS18000 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AL468_RS18005 ENOG4105C01 Dihydroxy-acid dehydratase AL468_RS18015 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AL468_RS18020 ENOG41064T2 transcriptional regulator, lysR family AL468_RS18025 ENOG4105DIQ Transcriptional regulator AL468_RS18065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_RS18070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL468_RS18120 ENOG4105MPD Cytochrome AL468_RS18125 ENOG4105C4R Atp-dependent dna helicase AL468_RS18130 ENOG41067SE Tetr family transcriptional regulator AL468_RS18135 ENOG410624X efflux transporter, rnd family, mfp subunit AL468_RS18140 ENOG4105BZS acriflavin resistance protein AL468_RS18145 ENOG4105W0Z cytoplasmic protein AL468_RS18155 ENOG4105EMY transcriptional regulator AL468_RS18195 ENOG4108Z0R Transferase AL468_RS18200 ENOG4105SG3 Protein of unknown function (DUF1488) AL468_RS18205 ENOG4105E2X shikimate dehydrogenase AL468_RS18210 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AL468_RS18215 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL468_RS18220 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AL468_RS18225 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AL468_RS18230 ENOG4108WI1 Dna topoisomerase AL468_RS18235 ENOG4108RPN Protein smg homolog AL468_RS18240 ENOG4105C79 DNA protecting protein DprA AL468_RS18255 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AL468_RS18260 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL468_RS18265 ENOG4105C1A potassium transporter peripheral membrane AL468_RS18270 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL468_RS18280 ENOG4108UT2 hemolysin iii AL468_RS18285 ENOG4108N23 SpoOM-related protein AL468_RS18295 ENOG4105PC1 Conserved Protein AL468_RS18305 ENOG4105E27 serine threonine protein kinase AL468_RS18310 ENOG4108Z33 Thiol disulfide Interchange Protein AL468_RS18315 ENOG4106HNH Acyl-transferase AL468_RS18325 ENOG4105C0P Mg chelatase subunit ChlI AL468_RS18335 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AL468_RS18340 ENOG4105CM2 brancheD-chain amino acid aminotransferase AL468_RS18345 ENOG4105C01 Dihydroxy-acid dehydratase AL468_RS18350 ENOG4105C7B Threonine dehydratase AL468_RS18355 ENOG4105F52 Transcriptional regulator AL468_RS18360 ENOG4105CZQ inner membrane transport protein YdhC AL468_RS18365 ENOG4105F87 Dehydratase AL468_RS18370 ENOG4105EAD ABC transporter AL468_RS18375 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AL468_RS18380 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AL468_RS18385 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AL468_RS18390 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AL468_RS18395 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AL468_RS18400 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL468_RS18410 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL468_RS18415 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AL468_RS18420 ENOG410684E atp synthase AL468_RS18425 ENOG4105FA0 parb-like partition protein AL468_RS18430 ENOG4107QJE Chromosome Partitioning Protein AL468_RS18435 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AL468_RS18440 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AL468_RS18445 ENOG4105QTB Flavodoxin AL468_RS18450 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AL468_RS18455 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AL468_RS18465 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AL468_RS18475 ENOG4105CDA abc transporter atp-binding protein AL468_RS18480 ENOG4105E5Q amino acid AbC transporter AL468_RS18485 ENOG4105EAB amino acid AbC transporter AL468_RS18495 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL468_RS18500 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AL468_RS18505 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AL468_RS18510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_RS18525 ENOG4108ZNX Heat shock protein AL468_RS18530 ENOG4105JKW Valine--pyruvate aminotransferase AL468_RS18535 ENOG4107T9C Alpha amylase catalytic region AL468_RS18540 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AL468_RS18545 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AL468_RS18560 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AL468_RS18575 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AL468_RS18580 ENOG4105CHU acetyl-coa acetyltransferase AL468_RS18585 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL468_RS18590 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AL468_RS18595 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL468_RS18600 ENOG4108RR8 protoporphyrinogen oxidase AL468_RS18650 ENOG4105E3B Multicopper oxidase AL468_RS18655 ENOG4105WMR Protein CrcB homolog AL468_RS18660 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AL468_RS18670 ENOG4105D06 uba thif-type nad fad binding protein AL468_RS18680 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AL468_RS18685 ENOG4105D41 biosynthesis protein thiH AL468_RS18690 ENOG4105DC7 peptidase M24 AL468_RS18690 ENOG4105DC7 peptidase M24 AL468_RS18695 ENOG4105G2Y Transcriptional regulator AL468_RS18720 ENOG4105E18 UPF0276 protein AL468_RS18730 ENOG4105C4R Atp-dependent dna helicase AL468_RS18740 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL468_RS18745 ENOG4105CCF Lysine exporter protein (Lyse ygga) AL468_RS18755 ENOG4105FR1 rard protein AL468_RS18760 ENOG4105C9U ATP-dependent DNA helicase RecQ AL468_RS18770 ENOG4105EX9 Membrane AL468_RS18775 ENOG4105C9X ppx gppa phosphatase AL468_RS18780 ENOG4105C1J atp-dependent rna helicase AL468_RS18790 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AL468_RS18805 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AL468_RS18815 ENOG4107QK7 reductase AL468_RS18855 ENOG410601J HemY protein AL468_RS18860 ENOG4105ECF c-methyltransferase AL468_RS18865 ENOG41076E6 Uroporphyrinogen-III Synthase AL468_RS18870 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AL468_RS18875 ENOG4107T0K Adenylate cyclase AL468_RS18880 ENOG4105XQ6 frataxin-like protein AL468_RS18890 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL468_RS18895 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AL468_RS18905 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL468_RS18910 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AL468_RS18915 ENOG4105BZU Histidine kinase AL468_RS18920 ENOG4106IUH DTW domain containing protein AL468_RS18935 ENOG4105DQF Hydrolase AL468_RS18940 ENOG4108EUD Lysophospholipase AL468_RS18945 ENOG410829K Lysine exporter protein (Lyse ygga) AL468_RS18950 ENOG4105D58 Diguanylate phosphodiesterase AL468_RS18955 ENOG41082YX Transcriptional regulator, arsr family AL468_RS18960 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL468_RS19010 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AL468_RS19020 ENOG4106H78 methyltransferase AL468_RS19025 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AL468_RS19030 ENOG4105CAK Cell division ATP-binding protein ftsE AL468_RS19035 ENOG4105CRP Part of the ABC transporter FtsEX involved in AL468_RS19040 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_RS19050 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL468_RS19055 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AL468_RS19060 ENOG4105X6C Flagellar basal body-associated protein FliL AL468_RS19065 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AL468_RS19070 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AL468_RS19075 ENOG4105E55 glycerol-3-phosphate acyltransferase AL468_RS19085 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AL468_RS19100 ENOG4107R73 Mate efflux family protein AL468_RS19105 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AL468_RS19120 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AL468_RS19125 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AL468_RS19135 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AL468_RS19170 ENOG4105JIM Phosphatidylserine synthase AL468_RS19180 ENOG4105D4A Cell wall formation (By similarity) AL468_RS19185 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AL468_RS19190 ENOG4105CS9 pantothenic acid kinase AL468_RS19220 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL468_RS19230 ENOG4105PM1 preprotein translocase subunit SecE AL468_RS19235 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AL468_RS19240 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AL468_RS19245 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AL468_RS19250 ENOG4108VZM 50s ribosomal protein L10 AL468_RS19255 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AL468_RS19260 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL468_RS19265 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL468_RS19270 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor AL468_RS19275 ENOG4105E09 nadh pyrophosphatase AL468_RS19280 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AL468_RS19285 ENOG4108RG0 uracil-dna glycosylase AL468_RS19290 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AL468_RS19295 ENOG4105R2J Conserved Protein AL468_RS19315 ENOG4105C12 Phosphoribosylglycinamide synthetase AL468_RS19325 ENOG4105DC1 bifunctional purine biosynthesis protein purh AL468_RS19335 ENOG4105W1Y Transcriptional regulator AL468_RS19340 ENOG4108M3R transcriptional activator CadC AL468_RS19350 ENOG4105D5Q Arginine ornithine antiporter AL468_RS19355 ENOG4105CXN decarboxylase AL468_RS19410 ENOG4105C5H ABC transporter AL468_RS19420 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AL468_RS19425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL468_RS19430 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AL468_RS19440 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AL468_RS19445 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AL468_RS19450 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AL468_RS19455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL468_RS19470 ENOG4105D8G Major Facilitator superfamily AL468_RS19475 ENOG4105BZU Histidine kinase AL468_RS19480 ENOG4105C9Q fumarate hydratase class II AL468_RS19495 ENOG4107QN1 sodium solute AL468_RS19505 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AL468_RS19515 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL468_RS19520 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AL468_RS19525 ENOG4108IJ0 Aspartate ammonia-lyase AL468_RS19530 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 AL468_RS19535 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AL468_RS19545 ENOG4105E0F Histidine kinase AL468_RS19550 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL468_RS19555 ENOG4108SPG Periplasmic Protein AL468_RS19560 ENOG41076HS cation diffusion facilitator family transporter AL468_RS19565 ENOG4105CTQ phosphohexokinase AL468_RS19575 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL468_RS19580 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL468_RS19590 ENOG4105KT7 mgtC SapB transporter AL468_RS19595 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AL468_RS19600 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AL468_RS19610 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL468_RS19615 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AL468_RS19620 ENOG4105E33 succinate dehydrogenase AL468_RS19630 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AL468_RS19640 ENOG41062JF Transcriptional regulator AL468_RS19650 ENOG41063SB peptidase AL468_RS19655 ENOG4105D7W serine acetyltransferase AL468_RS19660 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AL468_RS19665 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AL468_RS19670 ENOG4107YZP Rhodanese domain protein AL468_RS19675 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AL468_RS19685 ENOG4105C8P )-transporter AL468_RS19690 ENOG4105DJ4 phosphatidylserine decarboxylase AL468_RS19695 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL468_RS19700 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AL468_RS19765 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AL468_RS19775 ENOG4105K8N protein family UPF0079, ATPase AL468_RS19780 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AL468_RS19785 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AL468_RS19790 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AL468_RS19795 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AL468_RS19800 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AL468_RS19805 ENOG4107QJR hflk protein AL468_RS19810 ENOG4105EPW hflc protein AL468_RS19820 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL468_RS19830 ENOG4108UV7 flagellar protein motX AL468_RS19835 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL468_RS19840 ENOG4105KPV Transcriptional regulator AL468_RS19845 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AL468_RS19850 ENOG4105C2N RNA methyltransferase TrmH family group 3 AL468_RS19855 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL468_RS19860 ENOG4105C31 Tryptophanyl-tRNA synthetase AL468_RS19875 ENOG4105DDQ anthranilate synthase AL468_RS19880 ENOG4105C8Y Acetylornithine aminotransferase AL468_RS19890 ENOG4105C26 Dehydrogenase AL468_RS19905 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AL468_RS19910 ENOG4105YP7 UPF0270 protein AL468_RS19915 ENOG4105DNZ Alpha Beta Hydrolase AL468_RS19925 ENOG4105C5H ABC transporter AL468_RS19930 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AL468_RS19945 ENOG4108YZY peptidylprolyl cis-trans isomerase AL468_RS19950 ENOG4105D44 asparaginase AL468_RS19955 ENOG41069P5 Protein slyX homolog AL468_RS19965 ENOG4108V1T peptidylprolyl cis-trans isomerase AL468_RS19970 ENOG4105WWK YheO domain protein AL468_RS19975 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AL468_RS19980 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AL468_RS19985 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AL468_RS19990 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AL468_RS19995 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AL468_RS20000 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL468_RS20005 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL468_RS20010 ENOG4105W53 bacterioferritin-associated ferredoxin AL468_RS20015 ENOG4108UQY Iron-storage protein AL468_RS20020 ENOG4105C6K Malic enzyme AL468_RS20025 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AL468_RS20030 ENOG4105C28 cystathionine AL468_RS20035 ENOG4105CFH Aspartokinase AL468_RS20040 ENOG4105SYT Methylenetetrahydrofolate reductase AL468_RS20050 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AL468_RS20055 ENOG4105CWC Acetylornithine deacetylase AL468_RS20060 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AL468_RS20065 ENOG4105CAS nag kinase AL468_RS20070 ENOG4105CDH Citrulline--aspartate ligase AL468_RS20075 ENOG4105CH7 arginosuccinase AL468_RS20090 ENOG4107QN2 dihydrolipoyl dehydrogenase AL468_RS20095 ENOG4105EHV domain protein AL468_RS20105 ENOG4105C5Q Transcriptional regulator AL468_RS20110 ENOG4108JQC penicillin-binding protein 1A AL468_RS20135 ENOG4105E4G Type IV pilus AL468_RS20140 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AL468_RS20145 ENOG4105D49 3-dehydroquinate synthase AL468_RS20155 ENOG4105DFE Dna adenine methylase AL468_RS20160 ENOG4105DJV ribulose-phosphate 3-epimerase AL468_RS20165 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AL468_RS20170 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) AL468_RS20175 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AL468_RS20180 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AL468_RS20190 ENOG4105CDU Replicative dna helicase AL468_RS20195 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL468_RS20200 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AL468_RS20205 ENOG4107QP8 phosphohexose isomerase AL468_RS20215 ENOG4105MYN Zinc uptake regulation protein AL468_RS20220 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL468_RS20240 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AL468_RS20245 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AL468_RS20250 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AL468_RS20310 ENOG4105EEQ Na H antiporter AL468_RS20315 ENOG4105C3R Methionine synthase AL468_RS20320 ENOG4105CFH Aspartokinase AL468_RS20330 ENOG4105C5R Aminotransferase AL468_RS20340 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AL468_RS20345 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AL468_RS20350 ENOG41086KC Transcriptional regulator AL468_RS20355 ENOG4108UUM single-stranded DNA-binding protein AL468_RS20385 ENOG4107QYX exodeoxyribonuclease v alpha AL468_RS20410 ENOG41062P1 Diguanylate cyclase phosphodiesterase AL468_RS20445 ENOG4107QHF type ii secretion system protein e AL468_RS20450 ENOG4105D7Q type ii secretion system AL468_RS20500 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AL468_RS20505 ENOG4105VQ7 Rod shape-determining protein MreD AL468_RS20510 ENOG4108Z03 MAF-like protein AL468_RS20515 ENOG4105C03 ribonuclease AL468_RS20520 ENOG4105QD6 exported protein AL468_RS20530 ENOG4105D1U peptidase U62 modulator of DNA gyrase AL468_RS20535 ENOG4108IAB Phoh family AL468_RS20540 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AL468_RS20545 ENOG4105K3M )-transporter AL468_RS20550 ENOG4105D3G Pseudouridine synthase AL468_RS20555 ENOG4105C5I Dehydrogenase AL468_RS20560 ENOG4105N42 UPF0307 protein AL468_RS20565 ENOG4105CMS peptidase U62, modulator of DNA gyrase AL468_RS20570 ENOG4105CJW magnesium transporter AL468_RS20575 ENOG41080Z8 PHOSPHOCARRIER protein AL468_RS20580 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AL468_RS20585 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AL468_RS20590 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AL468_RS20595 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_RS20600 ENOG4108IUZ ABC transporter AL468_RS20605 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AL468_RS20615 ENOG4105C2X Arabinose 5-phosphate isomerase AL468_RS20625 ENOG4105DHJ ABC, transporter AL468_RS20630 ENOG4105CY3 ABC transporter, permease AL468_RS20635 ENOG4107PE3 Mammalian cell entry related domain protein AL468_RS20640 ENOG4105E3I toluene tolerance AL468_RS20650 ENOG4105VFK BolA family AL468_RS20655 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AL468_RS20660 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AL468_RS20665 ENOG4105KME endoribonuclease L-psp AL468_RS20670 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AL468_RS20675 ENOG4105CXT aspartate transcarbamylase AL468_RS20685 ENOG4105DBV ornithine carbamoyltransferase AL468_RS20690 ENOG4105CEU Arginine dihydrolase AL468_RS20705 ENOG4108MJ3 acetyltransferase AL468_RS20715 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AL468_RS20720 ENOG4105MYG DNA polymerase iii, chi subunit AL468_RS20730 ENOG4108M8S permease YjgP YjgQ family protein AL468_RS20735 ENOG4108K5H permease YjgP YjgQ family protein AL468_RS20750 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL468_RS20765 ENOG4105VZJ PTS System AL468_RS20770 ENOG4105CK1 PTS System AL468_RS20775 ENOG4105VCP PTS System AL468_RS20780 ENOG4105F8D glycoside hydrolase family 4 AL468_RS20785 ENOG410901P UPF0249 protein AL468_RS20795 ENOG4108ESY Metal dependent phosphohydrolase AL468_RS20840 ENOG4105C26 Dehydrogenase AL468_RS20870 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS20915 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AL468_RS20920 ENOG4105CEN a g-specific adenine glycosylase AL468_RS20925 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AL468_RS20935 ENOG4105CSV Glutaminase AL468_RS20940 ENOG4105CSA Coproporphyrinogen iii oxidase AL468_RS20945 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL468_RS20955 ENOG4105VZ9 UPF0235 protein AL468_RS20960 ENOG4108VIA integral membrane protein AL468_RS20965 ENOG4105II7 pyrroline-5-carboxylate reductase AL468_RS20970 ENOG4105DFA alanine racemase domain protein AL468_RS20975 ENOG4105CZX twitching motility protein AL468_RS20980 ENOG4105CZX twitching motility protein AL468_RS20985 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AL468_RS20990 ENOG4108UJU UPF0301 protein AL468_RS20995 ENOG4105D7Z glutathione synthase AL468_RS21000 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AL468_RS21005 ENOG4105RWS endonuclease I AL468_RS21010 ENOG4105GPY SprT protein AL468_RS21020 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AL468_RS21030 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL468_RS21035 ENOG4108R4R Iron-regulated virulence regulatory protein AL468_RS21040 ENOG4105D05 Receptor AL468_RS21045 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL468_RS21050 ENOG4105BZA Phosphoglycerate kinase AL468_RS21055 ENOG4105D2N Aldolase AL468_RS21060 ENOG4105D64 Mechanosensitive ion channel AL468_RS21075 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AL468_RS21080 ENOG4105MPN Membrane AL468_RS21085 ENOG4108JQ1 Dehydrogenase AL468_RS21090 ENOG4105E66 phosphoriboisomerase A AL468_RS21095 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AL468_RS21105 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AL468_RS21120 ENOG4105D0A hydroxylase AL468_RS21125 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL468_RS21140 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AL468_RS21145 ENOG4105Y75 tpr repeat protein AL468_RS21155 ENOG4108IYU L-aspartate oxidase AL468_RS21165 ENOG4105EMN RNA polymerase sigma factor AL468_RS21185 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AL468_RS21190 ENOG4105C3F Signal peptidase i AL468_RS21195 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AL468_RS21200 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AL468_RS21205 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AL468_RS21210 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AL468_RS21215 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AL468_RS21220 ENOG4105BZU Histidine kinase AL468_RS21230 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AL468_RS21240 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL468_RS21245 ENOG4105DXN mazG family AL468_RS21250 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AL468_RS21255 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AL468_RS21260 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL468_RS21265 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AL468_RS21270 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AL468_RS21275 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AL468_RS21280 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AL468_RS21285 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AL468_RS21295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_RS21300 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AL468_RS21305 ENOG4107TH8 cina domain protein AL468_RS21310 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AL468_RS21315 ENOG4105Y3E Modulates RecA activity (By similarity) AL468_RS21320 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL468_RS21325 ENOG4105CFH Aspartokinase AL468_RS21330 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AL468_RS21395 ENOG4107QSA Oxaloacetate decarboxylase AL468_RS21400 ENOG4105D9Q decarboxylase (Beta subunit) AL468_RS21410 ENOG4105W39 Membrane AL468_RS21420 ENOG4105D9M gamma-glutamylcysteine synthetase AL468_RS21435 ENOG4108JU6 CBS domain protein AL468_RS21440 ENOG4106KVJ cytochrome C assembly protein AL468_RS21445 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AL468_RS21450 ENOG4105K5M 30s ribosomal protein S16 AL468_RS21455 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AL468_RS21460 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AL468_RS21465 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AL468_RS21470 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AL468_RS21475 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AL468_RS21480 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AL468_RS21485 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AL468_RS21490 ENOG4105D7Q type ii secretion system AL468_RS21495 ENOG4107QHF type ii secretion system protein e AL468_RS21500 ENOG4108ZUW Major pilin subunit AL468_RS21510 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AL468_RS21520 ENOG41073TP transcriptional regulator AL468_RS21525 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AL468_RS21530 ENOG4107QSN dihydrolipoamide acetyltransferase AL468_RS21535 ENOG4107QN2 dihydrolipoyl dehydrogenase AL468_RS21540 ENOG410630P Transcriptional regulator AL468_RS21545 ENOG4108UGV hypoxanthine phosphoribosyltransferase AL468_RS21550 ENOG41077A9 carbonic anhydrase AL468_RS21555 ENOG4105CHH sulfate transporter AL468_RS21560 ENOG4105DA5 (ABC) transporter AL468_RS21565 ENOG4105E3A (ABC) transporter AL468_RS21575 ENOG4105D1S lipid A biosynthesis AL468_RS21580 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AL468_RS21585 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AL468_RS21590 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL468_RS21595 ENOG4105DJ0 Poly(A) Polymerase AL468_RS21600 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AL468_RS21605 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AL468_RS21610 ENOG4105PW4 Sugar fermentation stimulation protein homolog AL468_RS21615 ENOG4105CQ7 ATP-dependent helicase AL468_RS21620 ENOG4105BZ4 penicillin-binding protein AL468_RS21625 ENOG4105D78 K07001 NTE family protein AL468_RS21630 ENOG4107QIJ Aconitate hydratase 2 AL468_RS21635 ENOG4105XTV UPF0231 protein AL468_RS21660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL468_RS21675 ENOG4105E2D ec 3.2.1.52 AL468_RS21680 ENOG4105RD7 BadF BadG BcrA BcrD AL468_RS21690 ENOG4108JQ7 (ABC) transporter AL468_RS21695 ENOG4105C3U ABC transporter AL468_RS21700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_RS21710 ENOG4107QRA Extracellular solute-binding protein, family 5 AL468_RS21720 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL468_RS21725 ENOG4105F4G Membrane AL468_RS21730 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AL468_RS21735 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AL468_RS21750 ENOG4105DR5 peptidase AL468_RS21755 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL468_RS21765 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AL468_RS21770 ENOG4107QE9 Inherit from COG: Membrane AL468_RS21775 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL468_RS21780 ENOG4105HBR Rna-binding protein AL468_RS21785 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AL468_RS21790 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AL468_RS21795 ENOG4105EEI dihydropteroate synthase AL468_RS21800 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AL468_RS21810 ENOG4105NTZ Preprotein translocase subunit SecG AL468_RS21825 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AL468_RS21830 ENOG4105CHV Transcription elongation factor NusA AL468_RS21835 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AL468_RS21840 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AL468_RS21845 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AL468_RS21850 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AL468_RS21855 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AL468_RS21870 ENOG4105C3S Mate efflux family protein AL468_RS21885 ENOG4105BZU Histidine kinase AL468_RS21900 ENOG4108YYD acetyltransferase AL468_RS21920 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AL468_RS21930 ENOG4105EYA deoxyribonuclease AL468_RS21935 ENOG4105D9N nucleoside AL468_RS21945 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AL468_RS21950 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AL468_RS21955 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AL468_RS21960 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AL468_RS21970 ENOG4105EAC phosphoserine phosphatase AL468_RS21980 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AL468_RS21985 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL468_RS21990 ENOG4105ETT transcriptional Regulator, LysR family AL468_RS22000 ENOG4108IQE Amp-dependent synthetase and ligase AL468_RS22090 ENOG41064T2 transcriptional regulator, lysR family AL468_RS22095 ENOG4105E5D amino acid AL468_RS22100 ENOG4105FK9 beta-D-galactosidase beta subunit AL468_RS22105 ENOG4105CNT hydrolase family 2 AL468_RS22110 ENOG4105CQ4 Transcriptional regulator AL468_RS22120 ENOG4105CMR udp-glucose 4-epimerase AL468_RS22125 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AL468_RS22130 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AL468_RS22135 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AL468_RS22150 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AL468_RS22155 ENOG41060NJ transcriptional regulator AL468_RS22160 ENOG4108Y51 tRNA-binding protein AL468_RS22185 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AL468_RS22190 ENOG4105E98 transcriptional regulator DeoR family AL468_RS22195 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AL468_RS22200 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL468_RS22210 ENOG4105CXY transporter AL468_RS22215 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AL468_RS22220 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AL468_RS22225 ENOG4105X2V dna damage-inducible protein AL468_RS22230 ENOG4105EVZ LysR family transcriptional regulator AL468_RS22240 ENOG4105E68 Sulfatase AL468_RS22245 ENOG4105DSY exodeoxyribonuclease V, gamma AL468_RS22255 ENOG4107QKA exodeoxyribonuclease V beta AL468_RS22260 ENOG4107QYX exodeoxyribonuclease v alpha AL468_RS22285 ENOG4107QZM n-acetylglutamate synthase AL468_RS22300 ENOG4105CA3 membrane-bound lytic murein transglycosylase AL468_RS22305 ENOG4105CUZ uba thif-type nad fad binding protein AL468_RS22310 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AL468_RS22315 ENOG4105BZU Histidine kinase AL468_RS22320 ENOG4105C9B Cysteine desulfurase AL468_RS22325 ENOG4107S0N DJ-1 family AL468_RS22330 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AL468_RS22355 ENOG4105K6V RNA polymerase AL468_RS22370 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AL468_RS22375 ENOG4105IEY (LipO)protein AL468_RS22380 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AL468_RS22385 ENOG4105M85 Bola protein AL468_RS22395 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_RS22400 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_RS22405 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_RS22410 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_RS22415 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AL468_RS22420 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AL468_RS22425 ENOG4105CJ2 (LipO)protein AL468_RS22440 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AL468_RS22445 ENOG4105C9U ATP-dependent DNA helicase RecQ AL468_RS22450 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL468_RS22465 ENOG4105C8J )-transporter AL468_RS22475 ENOG4105W1I UPF0253 protein AL468_RS22485 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AL468_RS22490 ENOG4108R96 Methyltransferase, YaeB family AL468_RS22495 ENOG4105NRA 50s ribosomal protein l31 type b AL468_RS22505 ENOG4105CFC Transporter AL468_RS22530 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AL468_RS22535 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL468_RS22540 ENOG4108UPT UPF0178 protein AL468_RS22565 ENOG4105DR9 pseudouridine synthase AL468_RS22570 ENOG4105DR9 pseudouridine synthase AL468_RS22575 ENOG4108T8E UPF0325 protein AL468_RS22580 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AL468_RS22585 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AL468_RS22590 ENOG4105CE9 30S ribosomal protein S2 AL468_RS22595 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AL468_RS22600 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AL468_RS22605 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AL468_RS22610 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AL468_RS22615 ENOG4105KNE Phosphatidate cytidylyltransferase AL468_RS22620 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AL468_RS22625 ENOG4105DZP Membrane-associated zinc metalloprotease AL468_RS22630 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL468_RS22635 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AL468_RS22640 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_RS22645 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL468_RS22650 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_RS22655 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL468_RS22660 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL468_RS22665 ENOG4105C0B DNA polymerase III (alpha subunit) AL468_RS22670 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AL468_RS22675 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AL468_RS22680 ENOG4105N7H Cytochrome AL468_RS22685 ENOG4108YZA Nitrogen regulatory protein pii AL468_RS22690 ENOG4107NA1 Endonuclease Exonuclease phosphatase AL468_RS22700 ENOG4105E9H Lytic Murein transglycosylase AL468_RS22705 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AL468_RS22710 ENOG4105D1A Methyltransferase AL468_RS22715 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL468_RS22720 ENOG4107RZZ dna polymerase iii epsilon subunit AL468_RS22750 ENOG4107QPN acyl-Coa dehydrogenase AL468_RS22755 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL468_RS22760 ENOG4105E7A Glutamine amidotransferase AL468_RS22765 ENOG4108V3E phosphoribosylglycinamide formyltransferase AL468_RS22770 ENOG4105CXB phosphoribosylaminoimidazole synthetase AL468_RS22775 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AL468_RS22780 ENOG4105C2W permease AL468_RS22800 ENOG4105ERG peptidase m48, ste24p AL468_RS22815 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL468_RS22830 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL468_RS22845 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL468_RS22850 ENOG4105KUZ arsenate reductase AL468_RS22870 ENOG4105QZU Inner membrane protein YfeZ AL468_RS22875 ENOG4105EZR dyp-type peroxidase family protein AL468_RS22880 ENOG4105I03 Flagellin AL468_RS22890 ENOG4105I03 Flagellin AL468_RS22895 ENOG4105I03 Flagellin AL468_RS22900 ENOG41063QE flagellar protein FlaG AL468_RS22905 ENOG4107BRV flagellar capping protein AL468_RS22915 ENOG4105MQ3 flagellar protein FliS AL468_RS22925 ENOG4105BZU Histidine kinase AL468_RS22935 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AL468_RS22940 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL468_RS22945 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL468_RS22955 ENOG4108JIR Flagellum-specific ATP synthase AL468_RS22975 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL468_RS22980 ENOG4105DD5 Flagellar motor switch protein AL468_RS22985 ENOG4105VTB flagellar biosynthesis protein fliO AL468_RS22990 ENOG4105CN7 Flagellar biosynthetic protein FliP AL468_RS22995 ENOG4105VS8 Flagellar biosynthetic protein fliq AL468_RS23000 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL468_RS23005 ENOG4105D00 flagellar biosynthetic protein flhB AL468_RS23010 ENOG4105D7B Flagellar biosynthesis protein flha AL468_RS23015 ENOG4105FZW flagellar biosynthesis regulator FlhF AL468_RS23025 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL468_RS23030 ENOG4108VYJ response regulator receiver protein AL468_RS23035 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AL468_RS23045 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AL468_RS23050 ENOG4107QJE Chromosome Partitioning Protein AL468_RS23060 ENOG4108V3W Chemotaxis protein, CheW AL468_RS23070 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AL468_RS23075 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AL468_RS23080 ENOG41060IM Heme exporter protein AL468_RS23085 ENOG4105X3C heme exporter protein AL468_RS23090 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AL468_RS23095 ENOG4105DA4 cytochrome c-type biogenesis protein AL468_RS23100 ENOG4107QX9 Thiol disulfide interChange protein AL468_RS23105 ENOG4108M1T Cytochrome c-type biogenesis protein AL468_RS23110 ENOG4105KWW Biogenesis protein AL468_RS23115 ENOG410903C (LipO)protein AL468_RS23120 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_RS23125 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AL468_RS23140 ENOG4105CHU acetyl-coa acetyltransferase AL468_RS23145 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL468_RS23155 ENOG4107QXK peptidase AL468_RS23160 ENOG4108BY2 phosphohistidine phosphatase AL468_RS23165 ENOG4108DG9 Smr protein MutS2 AL468_RS23170 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AL468_RS23175 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AL468_RS23180 ENOG4105EN6 Membrane AL468_RS23190 ENOG4108BPE -transporting atpase AL468_RS23195 ENOG4105MH2 YfcL protein AL468_RS23205 ENOG4105Q8W reductase AL468_RS23210 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AL468_RS23215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_RS23225 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AL468_RS23230 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL468_RS23240 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AL468_RS23250 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AL468_RS23255 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AL468_RS23260 ENOG4108S3P Sporulation domain protein AL468_RS23265 ENOG4105E96 Colicin v production protein AL468_RS23270 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AL468_RS23275 ENOG4105EJC lysr family transcriptional regulator AL468_RS23280 ENOG4105I93 response regulator AL468_RS23290 ENOG4105WD1 Membrane AL468_RS23295 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AL468_RS23300 ENOG4107QMP dna polymerase iii subunits gamma and tau AL468_RS23305 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AL468_RS23310 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AL468_RS23315 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL468_RS23320 ENOG4105C44 Serine transporter AL468_RS23325 ENOG4105KME endoribonuclease L-psp AL468_RS23330 ENOG4105CEM UPF0597 protein AL468_RS23340 ENOG4105KRS Proteinase inhibitor AL468_RS23345 ENOG4105Y3U Transglycosylase-associated protein AL468_RS23350 ENOG4108ZZ3 UPF0260 protein AL468_RS23360 ENOG41067V3 Antibiotic biosynthesis monooxygenase AL468_RS23365 ENOG4108UYE Lactoylglutathione lyase AL468_RS23375 ENOG4105G6Z alkaline phosphatase AL468_RS23395 ENOG4105DHI Methyltransferase AL468_RS23400 ENOG4107SDU Methyl-accepting chemotaxis AL468_RS23405 ENOG4105DSB aldose 1-epimerase AL468_RS23410 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL468_RS23415 ENOG4105E0X reductase AL468_RS23425 ENOG4105VUT cytoplasmic protein AL468_RS23430 ENOG4105HDK L-asparaginase AL468_RS23435 ENOG4105D07 Signal peptide peptidase, SppA AL468_RS23440 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL468_RS23450 ENOG41069NU Nitroreductase AL468_RS23455 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AL468_RS23465 ENOG4108RU0 short-chain dehydrogenase reductase AL468_RS23470 ENOG4105DGU Histone deacetylase AL468_RS23480 ENOG4105E68 Sulfatase AL468_RS23485 ENOG4105YDX UPF0352 protein AL468_RS23490 ENOG4106V8H Nucleoid-associated protein AL468_RS23505 ENOG4105DFD Na H antiporter AL468_RS23510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL468_RS23515 ENOG4105EYW Ion transport protein AL468_RS23520 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AL468_RS23525 ENOG4105C0A alcohol dehydrogenase AL468_RS23540 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL468_RS23545 ENOG4105M2J Glutaredoxin AL468_RS23550 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL468_RS23645 ENOG4105ED4 portal protein AL468_RS23780 ENOG4105D3Y Na H antiporter AL468_RS23785 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AL468_RS23795 ENOG4105EIY sodium-type flagellar protein motY AL468_RS23800 ENOG4106WH9 Protein of unknown function (DUF2753) AL468_RS23805 ENOG4108UYE Lactoylglutathione lyase AL468_RS23810 ENOG4105CSM endonuclease III AL468_RS23815 ENOG4105DZB Electron transport complex AL468_RS23820 ENOG4108UQQ Electron transport complex AL468_RS23825 ENOG4105D6A Electron transport complex AL468_RS23835 ENOG4108R3D Electron transport complex AL468_RS23840 ENOG4105DGN Electron transport complex AL468_RS23855 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AL468_RS23860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL468_RS23870 ENOG4105CHW UPF0052 protein AL468_RS23875 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL468_RS23880 ENOG4108RIR Molybdenum cofactor biosynthesis protein AL468_RS23885 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL468_RS23890 ENOG4105M00 molybdopterin converting factor, subunit 1 AL468_RS23895 ENOG4108ZAF Molybdopterin AL468_RS23900 ENOG4107QSI ABC, transporter AL468_RS23905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL468_RS23910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL468_RS23915 ENOG4105C3U ABC transporter AL468_RS23920 ENOG4108JQ7 (ABC) transporter AL468_RS23925 ENOG4105CHF Glutathione S-transferase AL468_RS23935 ENOG4107PU6 Membrane AL468_RS23940 ENOG4108DNC Involved in acetate metabolism (By similarity) AL468_RS23945 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL468_RS23950 ENOG4105PQ6 UPF0208 membrane protein AL468_RS23960 ENOG4105C7J ABC transporter, permease AL468_RS23965 ENOG4108JJB ABC transporter AL468_RS23970 ENOG4107R28 alpha amylase, catalytic region AL468_RS23975 ENOG4105BZU Histidine kinase AL468_RS23980 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AL468_RS23985 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL468_RS23990 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AL468_RS24000 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AL468_RS24010 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AL468_RS24015 ENOG4105D1F ATP-binding protein AL468_RS24020 ENOG4105DBI uridine monophosphokinase AL468_RS24030 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AL468_RS24035 ENOG4105KJF protein tyrosine phosphatase AL468_RS24040 ENOG4105CHH sulfate transporter AL468_RS24050 ENOG4105C03 ribonuclease AL468_RS24055 ENOG4105EI2 Pseudouridine synthase AL468_RS24060 ENOG4108UHJ MAF-like protein AL468_RS24065 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AL468_RS24070 ENOG4105VGS 50s ribosomal protein l32 AL468_RS24075 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AL468_RS24080 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL468_RS24085 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AL468_RS24090 ENOG4105CHR reductase AL468_RS24095 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL468_RS24100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL468_RS24110 ENOG4105HHA aminodeoxychorismate lyase AL468_RS24115 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AL468_RS24120 ENOG4107QRG dna polymerase iii AL468_RS24125 ENOG4105F8V Hydrolase, tatD family AL468_RS24130 ENOG4105CI1 PTS System AL468_RS24145 ENOG4105C8J )-transporter AL468_RS24160 ENOG4108NRW Phospholipase, patatin family AL468_RS24165 ENOG4105CA9 Pyruvate kinase AL468_RS24170 ENOG4105DAG ROK family AL468_RS24180 ENOG4105C0B DNA polymerase III (alpha subunit) AL468_RS24195 ENOG4105UBK short-chain dehydrogenase reductase AL468_RS24200 ENOG4105ERU peptidase AL468_RS24205 ENOG4105CAT Cytidine monophosphate kinase AL468_RS24210 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AL468_RS24215 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL468_RS24220 ENOG4105Q4A inner membrane protein yciS AL468_RS24225 ENOG4105CFV Tetratricopeptide repeat protein AL468_RS24230 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AL468_RS24235 ENOG4108J59 Extracellular solute-binding protein, family 5 AL468_RS24250 ENOG4105DY2 Paraquat-inducible protein b AL468_RS24255 ENOG4105F1S paraquat-inducible protein a AL468_RS24260 ENOG4105NQN cytochrome C AL468_RS24270 ENOG4105DB1 molybdopterin oxidoreductase AL468_RS24275 ENOG4106WHD Tetrathionate reductase AL468_RS24280 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL468_RS24285 ENOG4106AFQ Histidine kinase AL468_RS24290 ENOG4108ZXC Two component transcriptional regulator, luxr family AL468_RS24300 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL468_RS24305 ENOG4105N6Y Thioredoxin AL468_RS24320 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AL468_RS24335 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL468_RS24345 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL468_RS24355 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL468_RS24385 ENOG4105J12 Multidrug resistance protein mdtN AL468_RS24390 ENOG4105JQN Transcriptional regulator AL468_RS24410 ENOG41062D9 Histidine kinase AL468_RS24415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL468_RS24425 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS24440 ENOG4105CCT upf0313 protein AL468_RS24460 ENOG4105DZ2 Transcriptional regulator AL468_RS24465 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL468_RS24475 ENOG4105K9H YciI-like protein AL468_RS24480 ENOG4105NAU thioesterase Superfamily protein AL468_RS24485 ENOG4107835 probably involved in intracellular septation (By similarity) AL468_RS24495 ENOG4105BZU Histidine kinase AL468_RS24505 ENOG4105CK2 sodium dicarboxylate symporter AL468_RS24515 ENOG4105CEY Amp-dependent synthetase and ligase AL468_RS24520 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL468_RS24525 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AL468_RS24530 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL468_RS24535 ENOG4105DK0 Indole-3-glycerol phosphate synthase AL468_RS24540 ENOG4108I0Q anthranilate phosphoribosyltransferase AL468_RS24545 ENOG4105DDQ anthranilate synthase AL468_RS24550 ENOG4105CRQ synthase (Component I) AL468_RS24560 ENOG4105DB7 PHP domain protein AL468_RS24565 ENOG4107RTD sua5 ycio yrdc ywlc family protein AL468_RS24575 ENOG4105FE9 pseudouridine synthase AL468_RS24580 ENOG4108W5H UPF0263 protein AL468_RS24595 ENOG4105CQ2 DNA polymerase AL468_RS24600 ENOG4105WH1 Two component transcriptional regulator luxr family AL468_RS24605 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AL468_RS24645 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) AL468_RS24670 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL468_RS24675 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL468_RS24680 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL468_RS24685 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL468_RS24700 ENOG4105EAU Plays a role in nitrite reduction (By similarity) AL468_RS24710 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL468_RS24715 ENOG4105DVI reductase, NrfD AL468_RS24720 ENOG4105DA4 cytochrome c-type biogenesis protein AL468_RS24725 ENOG4107QX9 Thiol disulfide interChange protein AL468_RS24730 ENOG4108DMF Cytochrome C biogenesis protein AL468_RS24740 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AL468_RS24765 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AL468_RS24770 ENOG4105EAQ (twin-arginine translocation) pathway signal AL468_RS24775 ENOG4105C5X domain protein AL468_RS24790 ENOG4105CH5 extracellular solute-binding protein, family 7 AL468_RS24800 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL468_RS24820 ENOG4105C94 Transporter AL468_RS24825 ENOG4105C8Q Methyl-accepting chemotaxis AL468_RS25010 ENOG4105CS1 NAD(P)H quinone oxidoreductase AL468_RS25015 ENOG4105K89 arsenate reductase