locus-tag	class	description
JOS67_RS00010	COG3119	arylsulfatase activity
JOS67_RS00015	COG0641	radical SAM
JOS67_RS00030	COG2184	nucleotidyltransferase activity
JOS67_RS00040	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JOS67_RS00045	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS00065	COG3716	PTS system mannose fructose sorbose family IID component
JOS67_RS00070	COG3715	PTS system
JOS67_RS00075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS00090	COG3344	reverse transcriptase
JOS67_RS00100	COG1192	Involved in chromosome partitioning
JOS67_RS00145	COG1414	Transcriptional regulator
JOS67_RS00190	COG1349	DNA-binding transcription factor activity
JOS67_RS00200	COG3119	arylsulfatase activity
JOS67_RS00220	COG2161	toxin-antitoxin pair type II binding
JOS67_RS00225	COG4115	mRNA cleavage
JOS67_RS00235	COG2195	Cleaves the N-terminal amino acid of tripeptides
JOS67_RS00240	COG3069	C4-dicarboxylate transmembrane transporter activity
JOS67_RS00265	COG3119	arylsulfatase activity
JOS67_RS00280	COG2222	sugar isomerase
JOS67_RS00285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS00290	COG3715	PTS system
JOS67_RS00295	COG3716	PTS system mannose fructose sorbose family IID component
JOS67_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS00320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JOS67_RS00345	COG3335	DDE superfamily endonuclease
JOS67_RS00360	COG5433	transposase activity
JOS67_RS00475	COG3335	DDE superfamily endonuclease
JOS67_RS00500	COG0800	Aldolase
JOS67_RS00505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JOS67_RS00515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JOS67_RS00520	COG0592	DNA-directed DNA polymerase activity
JOS67_RS00530	COG0187	DNA topoisomerase II activity
JOS67_RS00540	COG0071	Belongs to the small heat shock protein (HSP20) family
JOS67_RS00545	COG3977	Valine--pyruvate aminotransferase
JOS67_RS00550	COG0366	Alpha amylase catalytic
JOS67_RS00570	COG2119	membrane
JOS67_RS00580	COG0425	Belongs to the sulfur carrier protein TusA family
JOS67_RS00595	COG0604	alcohol dehydrogenase
JOS67_RS00600	COG0183	Belongs to the thiolase family
JOS67_RS00610	COG1739	Uncharacterized protein family UPF0029
JOS67_RS00615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JOS67_RS00670	COG2132	Multicopper oxidase
JOS67_RS00675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JOS67_RS00690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JOS67_RS00710	COG0006	proline dipeptidase activity
JOS67_RS00710	COG0006	proline dipeptidase activity
JOS67_RS00740	COG3220	belongs to the UPF0276 family
JOS67_RS00750	COG0210	DNA helicase
JOS67_RS00755	COG0405	Gamma-glutamyltransferase
JOS67_RS00760	COG1280	lysine exporter protein (LysE YggA)
JOS67_RS00770	COG2962	Rard protein
JOS67_RS00775	COG0514	ATP-dependent DNA helicase (RecQ)
JOS67_RS00785	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JOS67_RS00790	COG0248	Ppx GppA phosphatase
JOS67_RS00795	COG0513	Belongs to the DEAD box helicase family
JOS67_RS00800	COG3118	belongs to the thioredoxin family
JOS67_RS00815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JOS67_RS00820	COG0633	Ferredoxin
JOS67_RS00860	COG3071	HemY protein
JOS67_RS00865	COG2959	enzyme of heme biosynthesis
JOS67_RS00870	COG1587	Uroporphyrinogen-III synthase
JOS67_RS00875	COG0181	hydroxymethylbilane synthase activity
JOS67_RS00880	COG3072	Adenylate cyclase
JOS67_RS00885	COG1965	Belongs to the frataxin family
JOS67_RS00895	COG0019	diaminopimelate decarboxylase activity
JOS67_RS00900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JOS67_RS00910	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JOS67_RS00915	COG1011	Hydrolase
JOS67_RS00920	COG2199	diguanylate cyclase activity
JOS67_RS00920	COG2200	EAL domain
JOS67_RS00920	COG3287	FIST C domain
JOS67_RS00925	COG3148	PFAM DTW domain containing protein
JOS67_RS00940	COG0561	phosphatase activity
JOS67_RS00945	COG2267	carboxylic ester hydrolase activity
JOS67_RS00950	COG1280	lysine exporter protein (LysE YggA)
JOS67_RS00955	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JOS67_RS00960	COG0640	Transcriptional regulator
JOS67_RS00965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JOS67_RS01005	COG2095	MarC family integral membrane protein
JOS67_RS01015	COG0742	ribosomal rna small subunit methyltransferase
JOS67_RS01020	COG0552	protein localization to endoplasmic reticulum
JOS67_RS01025	COG2884	Cell division ATP-binding protein ftsE
JOS67_RS01030	COG2177	Part of the ABC transporter FtsEX involved in
JOS67_RS01040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JOS67_RS01045	COG0705	Rhomboid family
JOS67_RS01050	COG1580	Controls the rotational direction of flagella during chemotaxis
JOS67_RS01055	COG3161	chorismate lyase activity
JOS67_RS01060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JOS67_RS01065	COG2937	Belongs to the GPAT DAPAT family
JOS67_RS01070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JOS67_RS01080	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JOS67_RS01085	COG0534	Mate efflux family protein
JOS67_RS01090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JOS67_RS01110	COG4206	TonB-dependent receptor
JOS67_RS01175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JOS67_RS01185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JOS67_RS01190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JOS67_RS01190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JOS67_RS01220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JOS67_RS01225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JOS67_RS01230	COG0250	Participates in transcription elongation, termination and antitermination
JOS67_RS01245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JOS67_RS01250	COG0222	ribosome binding
JOS67_RS01255	COG0085	RNA polymerase activity
JOS67_RS01260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JOS67_RS01265	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
JOS67_RS01270	COG2816	NAD+ diphosphatase activity
JOS67_RS01275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JOS67_RS01280	COG1573	uracil-dna glycosylase
JOS67_RS01290	COG3068	Protein conserved in bacteria
JOS67_RS01295	COG1253	flavin adenine dinucleotide binding
JOS67_RS01310	COG0151	Belongs to the GarS family
JOS67_RS01315	COG0138	bifunctional purine biosynthesis protein purh
JOS67_RS01320	COG0789	Transcriptional regulator
JOS67_RS01325	COG3710	Transcriptional regulator
JOS67_RS01330	COG0531	amino acid
JOS67_RS01335	COG1982	Orn Lys Arg decarboxylase major
JOS67_RS01395	COG0488	(ABC) transporter
JOS67_RS01405	COG0582	viral genome integration into host DNA
JOS67_RS01430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JOS67_RS01435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JOS67_RS01440	COG2264	protein methyltransferase activity
JOS67_RS01445	COG0439	Biotin carboxylase
JOS67_RS01450	COG0511	ligase activity, forming carbon-carbon bonds
JOS67_RS01455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JOS67_RS01460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JOS67_RS01475	COG2814	Major facilitator Superfamily
JOS67_RS01500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JOS67_RS01510	COG3263	regulation of cellular component size
JOS67_RS01520	COG4232	protein-disulfide reductase activity
JOS67_RS01525	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JOS67_RS01530	COG1027	Aspartate ammonia-lyase
JOS67_RS01540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JOS67_RS01550	COG2205	protein histidine kinase activity
JOS67_RS01555	COG0745	RESPONSE REGULATOR receiver
JOS67_RS01560	COG3678	ATP-independent chaperone mediated protein folding
JOS67_RS01565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JOS67_RS01570	COG0205	6-phosphofructokinase activity
JOS67_RS01575	COG0534	Mate efflux family protein
JOS67_RS01585	COG0459	protein refolding
JOS67_RS01600	COG1285	pathogenesis
JOS67_RS01605	COG1509	lysine 2,3-aminomutase activity
JOS67_RS01625	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JOS67_RS01630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JOS67_RS01635	COG1053	succinate dehydrogenase
JOS67_RS01640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JOS67_RS01660	COG4942	peptidase
JOS67_RS01665	COG1045	serine acetyltransferase
JOS67_RS01670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JOS67_RS01675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JOS67_RS01680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JOS67_RS01685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JOS67_RS01695	COG3273	potassium ion transport
JOS67_RS01695	COG0471	metal ion transport
JOS67_RS01700	COG0688	phosphatidylethanolamine metabolic process
JOS67_RS01705	COG1162	GTPase activity
JOS67_RS01710	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JOS67_RS01775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JOS67_RS01780	COG0802	atpase or kinase
JOS67_RS01790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JOS67_RS01795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JOS67_RS01805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JOS67_RS01810	COG0330	HflC and HflK could
JOS67_RS01815	COG0330	HflC and HflK could
JOS67_RS01820	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JOS67_RS01825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JOS67_RS01830	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JOS67_RS01835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JOS67_RS01835	COG1017	nitric oxide dioxygenase activity
JOS67_RS01840	COG1959	2 iron, 2 sulfur cluster binding
JOS67_RS01845	COG0557	exoribonuclease II activity
JOS67_RS01850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JOS67_RS01855	COG0546	phosphoglycolate phosphatase activity
JOS67_RS01860	COG0180	Tryptophanyl-tRNA synthetase
JOS67_RS01880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JOS67_RS01900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JOS67_RS01905	COG3954	Phosphoribulokinase
JOS67_RS01910	COG3089	Belongs to the UPF0270 family
JOS67_RS01915	COG0429	hydrolase of the alpha beta-hydrolase fold
JOS67_RS01925	COG0488	(ABC) transporter
JOS67_RS01930	COG2249	NAD(P)H dehydrogenase (quinone) activity
JOS67_RS01945	COG1047	Peptidyl-prolyl cis-trans
JOS67_RS01950	COG1446	asparaginase
JOS67_RS01965	COG0545	Peptidyl-prolyl cis-trans isomerase
JOS67_RS01970	COG2964	Protein conserved in bacteria
JOS67_RS01975	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JOS67_RS01980	COG2923	Belongs to the DsrF TusC family
JOS67_RS01985	COG2168	tRNA wobble position uridine thiolation
JOS67_RS02000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JOS67_RS02005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JOS67_RS02010	COG2906	2 iron, 2 sulfur cluster binding
JOS67_RS02020	COG0281	malic enzyme
JOS67_RS02025	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
JOS67_RS02030	COG0626	cystathionine gamma-synthase activity
JOS67_RS02035	COG0527	aspartate kinase activity
JOS67_RS02035	COG0460	homoserine dehydrogenase
JOS67_RS02040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JOS67_RS02050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JOS67_RS02060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JOS67_RS02070	COG0137	argininosuccinate synthase activity
JOS67_RS02075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JOS67_RS02075	COG0165	Argininosuccinate lyase
JOS67_RS02085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JOS67_RS02090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JOS67_RS02090	COG0678	peroxiredoxin activity
JOS67_RS02100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JOS67_RS02130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JOS67_RS02135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JOS67_RS02145	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JOS67_RS02150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JOS67_RS02155	COG0360	Binds together with S18 to 16S ribosomal RNA
JOS67_RS02160	COG2965	DNA replication, synthesis of RNA primer
JOS67_RS02185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JOS67_RS02190	COG0432	Pfam Uncharacterised protein family UPF0047
JOS67_RS02195	COG0166	Belongs to the GPI family
JOS67_RS02205	COG0735	belongs to the Fur family
JOS67_RS02210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JOS67_RS02230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JOS67_RS02235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JOS67_RS02240	COG0175	sulfate reduction
JOS67_RS02305	COG0646	methionine synthase
JOS67_RS02305	COG1410	methionine synthase
JOS67_RS02310	COG0527	aspartate kinase activity
JOS67_RS02315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JOS67_RS02325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JOS67_RS02340	COG0629	single-stranded DNA binding
JOS67_RS02345	COG2199	diguanylate cyclase activity
JOS67_RS02345	COG2200	EAL domain
JOS67_RS02365	COG1450	Type ii and iii secretion system protein
JOS67_RS02370	COG3409	Peptidoglycan-binding domain 1 protein
JOS67_RS02370	COG3267	Type II secretory pathway component ExeA
JOS67_RS02380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JOS67_RS02385	COG1459	type II secretion system
JOS67_RS02395	COG5433	transposase activity
JOS67_RS02435	COG1077	Cell shape determining protein MreB Mrl
JOS67_RS02440	COG1792	Involved in formation and maintenance of cell shape
JOS67_RS02445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JOS67_RS02450	COG0424	maF-like protein
JOS67_RS02460	COG3164	Protein of unknown function
JOS67_RS02465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JOS67_RS02470	COG0312	modulator of DNA gyrase
JOS67_RS02475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JOS67_RS02480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JOS67_RS02490	COG0564	pseudouridine synthase activity
JOS67_RS02495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JOS67_RS02500	COG3028	Belongs to the UPF0307 family
JOS67_RS02505	COG0312	modulator of DNA gyrase
JOS67_RS02510	COG2239	Acts as a magnesium transporter
JOS67_RS02515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS02520	COG1660	Displays ATPase and GTPase activities
JOS67_RS02525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS02530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JOS67_RS02540	COG1137	ATPase activity
JOS67_RS02545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JOS67_RS02555	COG0517	IMP dehydrogenase activity
JOS67_RS02555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JOS67_RS02565	COG1127	ABC transporter
JOS67_RS02570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JOS67_RS02575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JOS67_RS02580	COG2854	intermembrane phospholipid transfer
JOS67_RS02590	COG5007	Belongs to the BolA IbaG family
JOS67_RS02600	COG0204	Acyl-transferase
JOS67_RS02605	COG0251	oxidation-reduction process
JOS67_RS02610	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JOS67_RS02615	COG0540	Belongs to the ATCase OTCase family
JOS67_RS02645	COG0456	acetyltransferase
JOS67_RS02655	COG0525	valine-tRNA ligase activity
JOS67_RS02660	COG2927	DNA polymerase III (CHI subunit)
JOS67_RS02670	COG0795	lipopolysaccharide-transporting ATPase activity
JOS67_RS02675	COG0795	lipopolysaccharide-transporting ATPase activity
JOS67_RS02700	COG0726	polysaccharide deacetylase
JOS67_RS02705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JOS67_RS02710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JOS67_RS02715	COG1447	Phosphotransferase system cellobiose-specific component IIA
JOS67_RS02720	COG1486	melibiose metabolic process
JOS67_RS02725	COG3394	polysaccharide catabolic process
JOS67_RS02735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JOS67_RS02800	COG0840	transmembrane signaling receptor activity
JOS67_RS02845	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JOS67_RS02855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JOS67_RS02865	COG2066	Belongs to the glutaminase family
JOS67_RS02870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JOS67_RS02875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JOS67_RS02885	COG1872	DUF167
JOS67_RS02890	COG0762	integral membrane protein
JOS67_RS02895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JOS67_RS02900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JOS67_RS02915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JOS67_RS02920	COG1678	Uncharacterized ACR, COG1678
JOS67_RS02925	COG0189	ligase activity
JOS67_RS02930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JOS67_RS02935	COG2356	endonuclease I
JOS67_RS02950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JOS67_RS02955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JOS67_RS02960	COG0583	DNA-binding transcription factor activity
JOS67_RS02965	COG4771	TonB-dependent receptor
JOS67_RS02970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JOS67_RS02975	COG0126	phosphoglycerate kinase activity
JOS67_RS02980	COG0191	fructose-bisphosphate aldolase activity
JOS67_RS02985	COG0668	transmembrane transport
JOS67_RS03000	COG0583	DNA-binding transcription factor activity
JOS67_RS03010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JOS67_RS03015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JOS67_RS03020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JOS67_RS03030	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JOS67_RS03035	COG3079	Belongs to the UPF0149 family
JOS67_RS03040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JOS67_RS03045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JOS67_RS03060	COG0354	folic acid binding
JOS67_RS03065	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JOS67_RS03070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JOS67_RS03075	COG1595	DNA-templated transcription, initiation
JOS67_RS03090	COG3086	response to oxidative stress
JOS67_RS03095	COG0481	GTPase activity
JOS67_RS03100	COG0681	Belongs to the peptidase S26 family
JOS67_RS03110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JOS67_RS03115	COG1381	Involved in DNA repair and RecF pathway recombination
JOS67_RS03120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JOS67_RS03125	COG0736	holo-[acyl-carrier-protein] synthase activity
JOS67_RS03135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JOS67_RS03140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JOS67_RS03145	COG3956	TIGRFAM MazG family protein
JOS67_RS03150	COG0504	CTP synthase activity
JOS67_RS03155	COG0148	phosphopyruvate hydratase activity
JOS67_RS03160	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JOS67_RS03165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JOS67_RS03170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JOS67_RS03180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JOS67_RS03185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JOS67_RS03195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JOS67_RS03200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JOS67_RS03205	COG1546	Belongs to the CinA family
JOS67_RS03215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JOS67_RS03310	COG2137	regulation of response to DNA damage stimulus
JOS67_RS03315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JOS67_RS03320	COG0527	aspartate kinase activity
JOS67_RS03380	COG3630	sodium ion export across plasma membrane
JOS67_RS03385	COG5016	pyruvate
JOS67_RS03385	COG0511	ligase activity, forming carbon-carbon bonds
JOS67_RS03390	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JOS67_RS03400	COG1238	metal cluster binding
JOS67_RS03405	COG0612	Peptidase, M16
JOS67_RS03420	COG1854	S-ribosylhomocysteine lyase activity
JOS67_RS03425	COG4536	flavin adenine dinucleotide binding
JOS67_RS03430	COG4137	Cytochrome C assembly protein
JOS67_RS03435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JOS67_RS03440	COG0228	four-way junction DNA binding
JOS67_RS03445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JOS67_RS03460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JOS67_RS03465	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JOS67_RS03470	COG0237	dephospho-CoA kinase activity
JOS67_RS03480	COG1459	type II secretion system
JOS67_RS03485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JOS67_RS03495	COG0157	Belongs to the NadC ModD family
JOS67_RS03505	COG2186	Transcriptional regulator
JOS67_RS03510	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JOS67_RS03515	COG0508	dehydrogenase complex catalyzes the overall conversion of
JOS67_RS03520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JOS67_RS03535	COG0288	reversible hydration of carbon dioxide
JOS67_RS03540	COG0659	secondary active sulfate transmembrane transporter activity
JOS67_RS03545	COG1131	(ABC) transporter
JOS67_RS03550	COG0842	Transport permease protein
JOS67_RS03555	COG1560	Kdo2-lipid A biosynthetic process
JOS67_RS03560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JOS67_RS03565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JOS67_RS03570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JOS67_RS03580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JOS67_RS03590	COG1489	DNA binding
JOS67_RS03595	COG1643	Atp-dependent helicase
JOS67_RS03600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JOS67_RS03605	COG1752	Esterase of the alpha-beta hydrolase superfamily
JOS67_RS03610	COG1049	propionate catabolic process, 2-methylcitrate cycle
JOS67_RS03615	COG3112	Uncharacterised protein family (UPF0231)
JOS67_RS03620	COG0347	Belongs to the P(II) protein family
JOS67_RS03625	COG0004	ammonium transporteR
JOS67_RS03630	COG1840	ABC-type Fe3 transport system, periplasmic component
JOS67_RS03640	COG3842	ATPase activity
JOS67_RS03645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JOS67_RS03660	COG2971	BadF BadG BcrA BcrD
JOS67_RS03670	COG4608	Belongs to the ABC transporter superfamily
JOS67_RS03675	COG0444	Belongs to the ABC transporter superfamily
JOS67_RS03680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JOS67_RS03690	COG0747	negative chemotaxis
JOS67_RS03695	COG2205	protein histidine kinase activity
JOS67_RS03695	COG0784	Response regulator, receiver
JOS67_RS03700	COG2813	Specifically methylates the guanine in position
JOS67_RS03705	COG0628	permease
JOS67_RS03710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JOS67_RS03730	COG0739	heme binding
JOS67_RS03735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JOS67_RS03745	COG2027	D-alanyl-D-alanine carboxypeptidase
JOS67_RS03750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JOS67_RS03755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JOS67_RS03760	COG1534	Rna-binding protein
JOS67_RS03765	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JOS67_RS03770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JOS67_RS03775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JOS67_RS03780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JOS67_RS03785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JOS67_RS03800	COG0779	Required for maturation of 30S ribosomal subunits
JOS67_RS03805	COG0195	Participates in both transcription termination and antitermination
JOS67_RS03810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JOS67_RS03815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JOS67_RS03820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JOS67_RS03825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JOS67_RS03830	COG1185	polyribonucleotide nucleotidyltransferase activity
JOS67_RS03850	COG0534	Mate efflux family protein
JOS67_RS03855	COG0826	peptidase U32
JOS67_RS03860	COG0826	peptidase U32
JOS67_RS03870	COG3154	lipid carrier protein
JOS67_RS03875	COG3153	acetyltransferase
JOS67_RS03895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JOS67_RS03905	COG0084	hydrolase, TatD family'
JOS67_RS03910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JOS67_RS03920	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JOS67_RS03925	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JOS67_RS03930	COG0813	purine-nucleoside phosphorylase activity
JOS67_RS03940	COG0560	Phosphoserine phosphatase
JOS67_RS03950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JOS67_RS03955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JOS67_RS03960	COG0583	DNA-binding transcription factor activity
JOS67_RS03970	COG1022	Amp-dependent synthetase and ligase
JOS67_RS04000	COG4964	Belongs to the GSP D family
JOS67_RS04060	COG0583	DNA-binding transcription factor activity
JOS67_RS04065	COG0531	amino acid
JOS67_RS04070	COG2731	YhcH YjgK YiaL family protein
JOS67_RS04075	COG3250	beta-galactosidase activity
JOS67_RS04080	COG1609	Transcriptional regulator
JOS67_RS04085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JOS67_RS04095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JOS67_RS04100	COG2017	converts alpha-aldose to the beta-anomer
JOS67_RS04115	COG2211	Major facilitator Superfamily
JOS67_RS04120	COG1609	Transcriptional regulator
JOS67_RS04125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JOS67_RS04150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JOS67_RS04155	COG1349	DNA-binding transcription factor activity
JOS67_RS04160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JOS67_RS04165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JOS67_RS04170	COG2271	Major facilitator Superfamily
JOS67_RS04175	COG0584	glycerophosphoryl diester phosphodiesterase
JOS67_RS04180	COG2171	N-acyltransferase activity
JOS67_RS04185	COG3141	response to X-ray
JOS67_RS04205	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JOS67_RS04210	COG1074	ATP-dependent DNA helicase activity
JOS67_RS04215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JOS67_RS04225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JOS67_RS04225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JOS67_RS04235	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JOS67_RS04240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JOS67_RS04245	COG2166	iron-sulfur cluster assembly
JOS67_RS04250	COG3706	GGDEF domain
JOS67_RS04255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JOS67_RS04260	COG0693	protein deglycase activity
JOS67_RS04265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JOS67_RS04270	COG3248	Nucleoside-binding outer membrane protein
JOS67_RS04285	COG1595	DNA-templated transcription, initiation
JOS67_RS04305	COG3056	Lipoprotein
JOS67_RS04310	COG2813	Specifically methylates the guanine in position
JOS67_RS04315	COG0271	Belongs to the BolA IbaG family
JOS67_RS04320	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JOS67_RS04325	COG1805	sodium ion transport
JOS67_RS04330	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JOS67_RS04335	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JOS67_RS04340	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JOS67_RS04345	COG2871	sodium ion transport
JOS67_RS04350	COG1477	protein flavinylation
JOS67_RS04365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JOS67_RS04370	COG0514	ATP-dependent DNA helicase (RecQ)
JOS67_RS04375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JOS67_RS04390	COG0733	neurotransmitter:sodium symporter activity
JOS67_RS04410	COG0442	prolyl-tRNA aminoacylation
JOS67_RS04415	COG1720	tRNA m6t6A37 methyltransferase activity
JOS67_RS04420	COG0254	rRNA binding
JOS67_RS04430	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JOS67_RS04455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JOS67_RS04460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JOS67_RS04495	COG0564	pseudouridine synthase activity
JOS67_RS04505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JOS67_RS04510	COG0024	Methionine aminopeptidase
JOS67_RS04515	COG0052	Belongs to the universal ribosomal protein uS2 family
JOS67_RS04520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JOS67_RS04525	COG0528	UMP kinase activity
JOS67_RS04530	COG0233	cytoplasmic translational termination
JOS67_RS04535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JOS67_RS04540	COG0575	Belongs to the CDS family
JOS67_RS04545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JOS67_RS04550	COG0750	zinc metalloprotease
JOS67_RS04560	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
JOS67_RS04565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JOS67_RS04575	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JOS67_RS04580	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JOS67_RS04590	COG0587	DNA-directed DNA polymerase activity
JOS67_RS04595	COG0825	malonyl-CoA metabolic process
JOS67_RS04610	COG0347	Belongs to the P(II) protein family
JOS67_RS04615	COG3021	interspecies interaction between organisms
JOS67_RS04625	COG0741	lytic transglycosylase activity
JOS67_RS04625	COG1388	LysM domain
JOS67_RS04630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JOS67_RS04635	COG2226	methyltransferase
JOS67_RS04640	COG0328	RNA-DNA hybrid ribonuclease activity
JOS67_RS04675	COG1960	acyl-CoA dehydrogenase activity
JOS67_RS04680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JOS67_RS04685	COG0121	glutamine amidotransferase
JOS67_RS04690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JOS67_RS04695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JOS67_RS04700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JOS67_RS04705	COG2233	PERMEase
JOS67_RS04725	COG1393	Belongs to the ArsC family
JOS67_RS04730	COG4783	chaperone-mediated protein folding
JOS67_RS04745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JOS67_RS04755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JOS67_RS04760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JOS67_RS04775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JOS67_RS04780	COG1393	Belongs to the ArsC family
JOS67_RS04805	COG2837	iron assimilation
JOS67_RS04810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS04815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS04820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS04825	COG1334	flagellar protein FlaG
JOS67_RS04830	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JOS67_RS04840	COG1516	flagellar protein fliS
JOS67_RS04860	COG1677	Flagellar hook-basal body complex protein FliE
JOS67_RS04870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JOS67_RS04920	COG1987	bacterial-type flagellum assembly
JOS67_RS04925	COG1684	flagellar biosynthetic protein fliR
JOS67_RS04960	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JOS67_RS04965	COG0784	Response regulator, receiver
JOS67_RS04965	COG0643	Histidine kinase
JOS67_RS04965	COG2198	Histidine kinase
JOS67_RS04970	COG2201	protein-glutamate methylesterase activity
JOS67_RS04975	COG1192	Involved in chromosome partitioning
JOS67_RS04985	COG0835	chemotaxis
JOS67_RS04995	COG4133	protoheme IX ABC transporter activity
JOS67_RS05000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JOS67_RS05005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JOS67_RS05010	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JOS67_RS05015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JOS67_RS05020	COG1138	Cytochrome C-type biogenesis protein
JOS67_RS05025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JOS67_RS05035	COG4235	cytochrome complex assembly
JOS67_RS05035	COG3088	subunit of a heme lyase
JOS67_RS05045	COG2067	long-chain fatty acid transport protein
JOS67_RS05065	COG0183	Belongs to the thiolase family
JOS67_RS05070	COG1024	Enoyl-CoA hydratase
JOS67_RS05070	COG1250	3-hydroxyacyl-CoA dehydrogenase
JOS67_RS05085	COG2062	phosphohistidine phosphatase, SixA
JOS67_RS05090	COG2840	Smr protein MutS2
JOS67_RS05095	COG2890	protein-(glutamine-N5) methyltransferase activity
JOS67_RS05100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JOS67_RS05105	COG2860	membrane
JOS67_RS05110	COG3101	peptidyl-lysine hydroxylation
JOS67_RS05120	COG0431	NADPH-dependent FMN reductase
JOS67_RS05125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JOS67_RS05125	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JOS67_RS05130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JOS67_RS05135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JOS67_RS05140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JOS67_RS05150	COG0101	tRNA pseudouridine synthase activity
JOS67_RS05155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JOS67_RS05160	COG0285	dihydrofolate synthase activity
JOS67_RS05165	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JOS67_RS05170	COG1286	toxin biosynthetic process
JOS67_RS05175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JOS67_RS05180	COG0583	DNA-binding transcription factor activity
JOS67_RS05185	COG0745	RESPONSE REGULATOR receiver
JOS67_RS05190	COG2832	Protein of unknown function (DUF454)
JOS67_RS05195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JOS67_RS05210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JOS67_RS05215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JOS67_RS05220	COG0814	amino acid
JOS67_RS05225	COG0251	oxidation-reduction process
JOS67_RS05230	COG3681	Belongs to the UPF0597 family
JOS67_RS05245	COG2261	transglycosylase associated protein
JOS67_RS05250	COG2983	Belongs to the UPF0260 family
JOS67_RS05255	COG0668	transmembrane transport
JOS67_RS05265	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JOS67_RS05270	COG0346	lactoylglutathione lyase activity
JOS67_RS05280	COG1785	Belongs to the alkaline phosphatase family
JOS67_RS05295	COG2226	methyltransferase
JOS67_RS05310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JOS67_RS05315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JOS67_RS05325	COG3139	Protein of unknown function (DUF1315)
JOS67_RS05330	COG0252	asparaginase activity
JOS67_RS05335	COG0616	signal peptide processing
JOS67_RS05340	COG0446	pyridine nucleotide-disulphide oxidoreductase
JOS67_RS05340	COG1902	pentaerythritol trinitrate reductase activity
JOS67_RS05350	COG0778	Nitroreductase
JOS67_RS05355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JOS67_RS05370	COG0123	including yeast histone deacetylase and acetoin utilization protein
JOS67_RS05385	COG3082	Protein of unknown function (DUF1414)
JOS67_RS05390	COG3081	Nucleoid-associated protein
JOS67_RS05405	COG1757	Na H antiporter
JOS67_RS05410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JOS67_RS05415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JOS67_RS05420	COG2095	MarC family integral membrane protein
JOS67_RS05425	COG1012	belongs to the aldehyde dehydrogenase family
JOS67_RS05425	COG1454	alcohol dehydrogenase
JOS67_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS05445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JOS67_RS05455	COG2056	Na+-H+ antiporter family
JOS67_RS05460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JOS67_RS05465	COG2885	chlorophyll binding
JOS67_RS05475	COG0346	lactoylglutathione lyase activity
JOS67_RS05480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JOS67_RS05485	COG4660	Part of a membrane complex involved in electron transport
JOS67_RS05490	COG4659	FMN binding
JOS67_RS05495	COG4658	electron transport chain
JOS67_RS05500	COG4656	Part of a membrane complex involved in electron transport
JOS67_RS05505	COG2878	Part of a membrane complex involved in electron transport
JOS67_RS05510	COG4657	Part of a membrane complex involved in electron transport
JOS67_RS05520	COG0556	nucleotide-excision repair
JOS67_RS05525	COG2204	response regulator
JOS67_RS05530	COG2198	Histidine kinase
JOS67_RS05535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JOS67_RS05540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JOS67_RS05545	COG0521	Mo-molybdopterin cofactor biosynthetic process
JOS67_RS05550	COG0315	cyclic pyranopterin monophosphate synthase activity
JOS67_RS05555	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JOS67_RS05560	COG0314	molybdopterin synthase activity
JOS67_RS05570	COG0601	transmembrane transport
JOS67_RS05575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JOS67_RS05580	COG0444	Belongs to the ABC transporter superfamily
JOS67_RS05590	COG0435	Glutathione S-transferase
JOS67_RS05600	COG3174	membrane
JOS67_RS05605	COG0280	phosphate acetyltransferase
JOS67_RS05605	COG0857	belongs to the CobB CobQ family
JOS67_RS05610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JOS67_RS05615	COG3092	negative regulation of chromosome organization
JOS67_RS05625	COG4120	Belongs to the binding-protein-dependent transport system permease family
JOS67_RS05630	COG1122	ATPase activity
JOS67_RS05635	COG0366	Alpha amylase catalytic
JOS67_RS05640	COG3706	GGDEF domain
JOS67_RS05645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JOS67_RS05650	COG0653	protein targeting
JOS67_RS05655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JOS67_RS05660	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JOS67_RS05665	COG2186	Transcriptional regulator
JOS67_RS05675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JOS67_RS05675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JOS67_RS05685	COG0572	uridine kinase
JOS67_RS05695	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JOS67_RS05700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JOS67_RS05705	COG0659	secondary active sulfate transmembrane transporter activity
JOS67_RS05710	COG1530	ribonuclease E activity
JOS67_RS05715	COG0564	pseudouridine synthase activity
JOS67_RS05720	COG0424	maF-like protein
JOS67_RS05725	COG1399	metal-binding, possibly nucleic acid-binding protein
JOS67_RS05735	COG0416	fatty acid biosynthetic process
JOS67_RS05740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JOS67_RS05770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JOS67_RS05775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JOS67_RS05780	COG0470	DNA polymerase III
JOS67_RS05785	COG0084	hydrolase, TatD family'
JOS67_RS05790	COG1263	PTS System
JOS67_RS05790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS05805	COG0733	neurotransmitter:sodium symporter activity
JOS67_RS05820	COG4667	esterase of the alpha-beta hydrolase superfamily
JOS67_RS05825	COG0469	pyruvate kinase activity
JOS67_RS05830	COG1940	carbohydrate kinase activity
JOS67_RS05835	COG0835	chemotaxis
JOS67_RS05835	COG0784	Response regulator, receiver
JOS67_RS05840	COG0587	DNA-directed DNA polymerase activity
JOS67_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS05860	COG0616	signal peptide processing
JOS67_RS05865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JOS67_RS05870	COG0539	negative regulation of cytoplasmic translation
JOS67_RS05880	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JOS67_RS05885	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JOS67_RS05895	COG4166	transmembrane transport
JOS67_RS05910	COG3008	intermembrane lipid transfer
JOS67_RS05910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JOS67_RS05915	COG2995	paraquat-inducible protein a
JOS67_RS05920	COG3258	Cytochrome c
JOS67_RS05925	COG2863	cytochrome
JOS67_RS05960	COG4232	protein-disulfide reductase activity
JOS67_RS05965	COG3118	belongs to the thioredoxin family
JOS67_RS05980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JOS67_RS05995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS06005	COG0577	efflux transmembrane transporter activity
JOS67_RS06005	COG1136	(ABC) transporter
JOS67_RS06015	COG1136	(ABC) transporter
JOS67_RS06015	COG0577	efflux transmembrane transporter activity
JOS67_RS06065	COG3850	Histidine kinase
JOS67_RS06065	COG5002	protein histidine kinase activity
JOS67_RS06070	COG0745	RESPONSE REGULATOR receiver
JOS67_RS06075	COG0840	transmembrane signaling receptor activity
JOS67_RS06090	COG1032	radical SAM domain protein
JOS67_RS06110	COG0583	DNA-binding transcription factor activity
JOS67_RS06115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JOS67_RS06125	COG2350	Protein conserved in bacteria
JOS67_RS06135	COG2917	probably involved in intracellular septation
JOS67_RS06155	COG1301	dicarboxylic acid transport
JOS67_RS06160	COG0318	PFAM AMP-dependent synthetase and ligase
JOS67_RS06165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JOS67_RS06170	COG0159	tryptophan synthase activity
JOS67_RS06180	COG0134	indole-3-glycerol-phosphate synthase activity
JOS67_RS06180	COG0135	phosphoribosylanthranilate isomerase activity
JOS67_RS06190	COG0512	Glutamine amidotransferase of anthranilate synthase
JOS67_RS06195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JOS67_RS06205	COG0613	PHP domain protein
JOS67_RS06210	COG0009	L-threonylcarbamoyladenylate synthase
JOS67_RS06220	COG1187	pseudouridine synthase activity
JOS67_RS06240	COG0417	DNA replication proofreading
JOS67_RS06245	COG2197	response regulator
JOS67_RS06250	COG0322	excinuclease ABC activity
JOS67_RS06290	COG0019	diaminopimelate decarboxylase activity
JOS67_RS06320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JOS67_RS06325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JOS67_RS06345	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JOS67_RS06355	COG0437	4 iron, 4 sulfur cluster binding
JOS67_RS06360	COG3301	Polysulphide reductase, NrfD
JOS67_RS06365	COG1138	Cytochrome C-type biogenesis protein
JOS67_RS06370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JOS67_RS06375	COG3088	subunit of a heme lyase
JOS67_RS06375	COG4235	cytochrome complex assembly
JOS67_RS06385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JOS67_RS06410	COG2989	Protein conserved in bacteria
JOS67_RS06415	COG3108	Peptidase M15
JOS67_RS06420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JOS67_RS06435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JOS67_RS06465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JOS67_RS06470	COG0840	transmembrane signaling receptor activity
JOS67_RS06490	COG1448	Aminotransferase
JOS67_RS06505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JOS67_RS06515	COG0017	Asparaginyl-tRNA synthetase
JOS67_RS06520	COG0840	transmembrane signaling receptor activity
JOS67_RS06525	COG0720	synthase
JOS67_RS06540	COG1760	l-serine dehydratase
JOS67_RS06545	COG0814	amino acid
JOS67_RS06550	COG0494	nUDIX hydrolase
JOS67_RS06560	COG2205	protein histidine kinase activity
JOS67_RS06560	COG0784	Response regulator, receiver
JOS67_RS06565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JOS67_RS06580	COG3106	COG3106 Predicted ATPase
JOS67_RS06585	COG3768	UPF0283 membrane protein
JOS67_RS06595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JOS67_RS06645	COG1192	Involved in chromosome partitioning
JOS67_RS06665	COG1596	polysaccharide export
JOS67_RS06665	COG1555	photosystem II stabilization
JOS67_RS06700	COG5433	transposase activity
JOS67_RS06760	COG0583	DNA-binding transcription factor activity
JOS67_RS06775	COG0583	DNA-binding transcription factor activity
JOS67_RS06780	COG0431	NADPH-dependent FMN reductase
JOS67_RS06785	COG0783	Belongs to the Dps family
JOS67_RS06790	COG0435	Glutathione S-transferase
JOS67_RS06795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JOS67_RS06810	COG2226	methyltransferase
JOS67_RS06815	COG0729	surface antigen
JOS67_RS06820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JOS67_RS06825	COG2272	Belongs to the type-B carboxylesterase lipase family
JOS67_RS06850	COG2985	domain, Protein
JOS67_RS06860	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JOS67_RS06875	COG0583	DNA-binding transcription factor activity
JOS67_RS06890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS06905	COG3290	protein histidine kinase activity
JOS67_RS06910	COG4565	transcriptional regulatory protein
JOS67_RS06925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JOS67_RS06930	COG0363	glucosamine-6-phosphate deaminase activity
JOS67_RS06935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JOS67_RS06955	COG3284	Transcriptional regulator
JOS67_RS06960	COG1012	belongs to the aldehyde dehydrogenase family
JOS67_RS07030	COG4669	(LipO)protein
JOS67_RS07050	COG3177	Filamentation induced by cAMP protein fic
JOS67_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS07110	COG4792	protein secretion
JOS67_RS07115	COG4791	protein targeting
JOS67_RS07120	COG4794	Type iii secretion
JOS67_RS07125	COG4790	Type iii secretion
JOS67_RS07195	COG0457	Tetratricopeptide repeat
JOS67_RS07210	COG2358	TRAP transporter, solute receptor (TAXI family
JOS67_RS07215	COG0730	response to heat
JOS67_RS07250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JOS67_RS07255	COG0372	Belongs to the citrate synthase family
JOS67_RS07265	COG2828	Protein conserved in bacteria
JOS67_RS07290	COG0561	phosphatase activity
JOS67_RS07295	COG0602	queuosine metabolic process
JOS67_RS07300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JOS67_RS07305	COG3706	GGDEF domain
JOS67_RS07330	COG5433	transposase activity
JOS67_RS07360	COG0840	transmembrane signaling receptor activity
JOS67_RS07365	COG1254	Belongs to the acylphosphatase family
JOS67_RS07370	COG2920	part of a sulfur-relay system
JOS67_RS07380	COG0670	Belongs to the BI1 family
JOS67_RS07385	COG1126	abc transporter atp-binding protein
JOS67_RS07390	COG0765	amino acid transport
JOS67_RS07395	COG4597	amino acid ABC transporter
JOS67_RS07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JOS67_RS07415	COG1666	GTP binding
JOS67_RS07420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JOS67_RS07445	COG3008	intermembrane lipid transfer
JOS67_RS07450	COG2995	paraquat-inducible protein a
JOS67_RS07455	COG1132	(ABC) transporter
JOS67_RS07460	COG1956	GAF domain-containing protein
JOS67_RS07465	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JOS67_RS07480	COG0308	aminopeptidase N
JOS67_RS07490	COG2902	Dehydrogenase
JOS67_RS07495	COG0167	dihydroorotate dehydrogenase activity
JOS67_RS07505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JOS67_RS07505	COG0116	Belongs to the methyltransferase superfamily
JOS67_RS07515	COG0488	(ABC) transporter
JOS67_RS07530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JOS67_RS07535	COG1067	ATP-dependent peptidase activity
JOS67_RS07540	COG3120	sequence-specific DNA binding
JOS67_RS07560	COG2205	protein histidine kinase activity
JOS67_RS07560	COG0784	Response regulator, receiver
JOS67_RS07575	COG3278	Belongs to the heme-copper respiratory oxidase family
JOS67_RS07590	COG2010	Cytochrome c
JOS67_RS07600	COG2217	Heavy metal translocating P-type atpase
JOS67_RS07615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JOS67_RS07620	COG0589	response to stress
JOS67_RS07645	COG3842	ATPase activity
JOS67_RS07655	COG1177	transmembrane transport
JOS67_RS07665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JOS67_RS07670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JOS67_RS07680	COG0004	ammonium transporteR
JOS67_RS07705	COG0437	4 iron, 4 sulfur cluster binding
JOS67_RS07710	COG3383	formate dehydrogenase (NAD+) activity
JOS67_RS07710	COG0243	molybdopterin cofactor binding
JOS67_RS07720	COG3381	protein complex oligomerization
JOS67_RS07740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JOS67_RS07745	COG0488	(ABC) transporter
JOS67_RS07750	COG4191	Histidine kinase
JOS67_RS07755	COG2204	response regulator
JOS67_RS07770	COG3842	ATPase activity
JOS67_RS07775	COG0746	molybdenum cofactor guanylyltransferase activity
JOS67_RS07790	COG1940	carbohydrate kinase activity
JOS67_RS07795	COG3148	PFAM DTW domain containing protein
JOS67_RS07825	COG0840	transmembrane signaling receptor activity
JOS67_RS07830	COG0791	NLP P60 protein
JOS67_RS07840	COG3706	GGDEF domain
JOS67_RS07850	COG3001	Fructosamine kinase
JOS67_RS07860	COG0307	riboflavin synthase, alpha
JOS67_RS07865	COG0534	Mate efflux family protein
JOS67_RS07875	COG1793	dna ligase
JOS67_RS07905	COG2204	response regulator
JOS67_RS07910	COG0297	glycogen (starch) synthase activity
JOS67_RS07915	COG0438	transferase activity, transferring glycosyl groups
JOS67_RS07945	COG0438	transferase activity, transferring glycosyl groups
JOS67_RS07950	COG1215	transferase activity, transferring glycosyl groups
JOS67_RS07955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JOS67_RS07965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JOS67_RS07980	COG1643	Atp-dependent helicase
JOS67_RS07985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JOS67_RS08030	COG0443	Heat shock 70 kDa protein
JOS67_RS08035	COG0443	Heat shock 70 kDa protein
JOS67_RS08060	COG1132	(ABC) transporter
JOS67_RS08065	COG1132	(ABC) transporter
JOS67_RS08075	COG4774	siderophore transport
JOS67_RS08085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JOS67_RS08090	COG1120	ATPase activity
JOS67_RS08105	COG0814	amino acid
JOS67_RS08115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JOS67_RS08125	COG0861	Integral membrane protein TerC family
JOS67_RS08135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JOS67_RS08140	COG1328	CTP reductase activity
JOS67_RS08155	COG5001	Diguanylate cyclase
JOS67_RS08155	COG3300	MHYT domain
JOS67_RS08165	COG4191	Histidine kinase
JOS67_RS08170	COG0471	metal ion transport
JOS67_RS08190	COG3706	GGDEF domain
JOS67_RS08195	COG4702	Belongs to the UPF0303 family
JOS67_RS08200	COG0673	inositol 2-dehydrogenase activity
JOS67_RS08205	COG1349	DNA-binding transcription factor activity
JOS67_RS08220	COG0641	radical SAM
JOS67_RS08235	COG3119	arylsulfatase activity
JOS67_RS08240	COG0527	aspartate kinase activity
JOS67_RS08245	COG0662	Cupin 2, conserved barrel domain protein
JOS67_RS08250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JOS67_RS08255	COG0456	acetyltransferase
JOS67_RS08260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JOS67_RS08280	COG4176	ABC-type proline glycine betaine transport system permease component
JOS67_RS08285	COG2113	Glycine betaine
JOS67_RS08305	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS08315	COG0745	RESPONSE REGULATOR receiver
JOS67_RS08320	COG0642	Histidine kinase
JOS67_RS08325	COG1368	sulfuric ester hydrolase activity
JOS67_RS08350	COG1115	amino acid carrier protein
JOS67_RS08360	COG1280	lysine exporter protein (LysE YggA)
JOS67_RS08365	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JOS67_RS08370	COG1560	Kdo2-lipid A biosynthetic process
JOS67_RS08375	COG0531	amino acid
JOS67_RS08390	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JOS67_RS08395	COG3063	Type IV pilus biogenesis stability protein PilW
JOS67_RS08425	COG0110	maltose O-acetyltransferase activity
JOS67_RS08440	COG2315	Protein conserved in bacteria
JOS67_RS08445	COG1846	Transcriptional regulator
JOS67_RS08460	COG2200	EAL domain
JOS67_RS08460	COG2771	luxR family
JOS67_RS08495	COG0625	glutathione transferase activity
JOS67_RS08505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JOS67_RS08515	COG2195	Cleaves the N-terminal amino acid of tripeptides
JOS67_RS08525	COG0601	transmembrane transport
JOS67_RS08530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JOS67_RS08550	COG3291	Pkd domain containing protein
JOS67_RS08565	COG1177	transmembrane transport
JOS67_RS08570	COG1176	ABC-type spermidine putrescine transport system, permease component I
JOS67_RS08575	COG3842	ATPase activity
JOS67_RS08580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JOS67_RS08585	COG2423	ornithine cyclodeaminase activity
JOS67_RS08600	COG3938	Belongs to the proline racemase family
JOS67_RS08630	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JOS67_RS08635	COG1451	nucleotide metabolic process
JOS67_RS08645	COG0583	DNA-binding transcription factor activity
JOS67_RS08665	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JOS67_RS08670	COG4139	cobalamin transport
JOS67_RS08675	COG2988	succinylglutamate desuccinylase activity
JOS67_RS08695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JOS67_RS08700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JOS67_RS08710	COG1823	symporter activity
JOS67_RS08715	COG2925	Exonuclease
JOS67_RS08720	COG1380	Effector of murein hydrolase LrgA
JOS67_RS08725	COG1346	cytolysis
JOS67_RS08730	COG0295	cytidine deaminase activity
JOS67_RS08735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JOS67_RS08740	COG0500	methyltransferase
JOS67_RS08750	COG0776	regulation of translation
JOS67_RS08760	COG0072	phenylalanine-tRNA ligase activity
JOS67_RS08760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JOS67_RS08765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JOS67_RS08795	COG0393	Putative heavy-metal-binding
JOS67_RS08805	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JOS67_RS08815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JOS67_RS08830	COG2188	Transcriptional regulator
JOS67_RS08835	COG1228	amidohydrolase
JOS67_RS08840	COG0010	Belongs to the arginase family
JOS67_RS08845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JOS67_RS08850	COG2986	histidine ammonia-lyase
JOS67_RS08865	COG0247	lactate metabolic process
JOS67_RS08865	COG0277	FAD linked oxidase domain protein
JOS67_RS08900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JOS67_RS08915	COG1643	Atp-dependent helicase
JOS67_RS08920	COG0281	malic enzyme
JOS67_RS08925	COG2949	membrane
JOS67_RS08930	COG0471	metal ion transport
JOS67_RS08955	COG0492	ferredoxin-NADP+ reductase activity
JOS67_RS08960	COG4988	ABC transporter
JOS67_RS08965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JOS67_RS08975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JOS67_RS08985	COG4191	Histidine kinase
JOS67_RS08985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JOS67_RS09000	COG3070	regulator of competence-specific genes
JOS67_RS09010	COG2431	L-lysine efflux transmembrane transporter activity
JOS67_RS09020	COG0076	glutamate decarboxylase activity
JOS67_RS09025	COG1737	Transcriptional regulator
JOS67_RS09035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JOS67_RS09040	COG3273	potassium ion transport
JOS67_RS09040	COG2985	domain, Protein
JOS67_RS09045	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JOS67_RS09050	COG1960	acyl-CoA dehydrogenase activity
JOS67_RS09060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JOS67_RS09080	COG0534	Mate efflux family protein
JOS67_RS09085	COG0702	epimerase
JOS67_RS09090	COG3005	denitrification pathway
JOS67_RS09120	COG2814	Major facilitator Superfamily
JOS67_RS09125	COG1187	pseudouridine synthase activity
JOS67_RS09130	COG1061	Type III restriction enzyme res subunit
JOS67_RS09150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JOS67_RS09160	COG0737	Belongs to the 5'-nucleotidase family
JOS67_RS09170	COG3313	Fe-S protein
JOS67_RS09180	COG4134	Bacterial extracellular solute-binding protein
JOS67_RS09185	COG4135	transport system, permease component
JOS67_RS09190	COG4136	ATPase activity
JOS67_RS09195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JOS67_RS09205	COG3604	Transcriptional regulator
JOS67_RS09210	COG1151	hydroxylamine reductase activity
JOS67_RS09215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JOS67_RS09225	COG0564	pseudouridine synthase activity
JOS67_RS09230	COG0733	neurotransmitter:sodium symporter activity
JOS67_RS09240	COG0626	cystathionine gamma-synthase activity
JOS67_RS09245	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JOS67_RS09250	COG5380	lipid catabolic process
JOS67_RS09255	COG2818	Glycosylase
JOS67_RS09275	COG1983	PspC domain protein
JOS67_RS09285	COG1842	Phage shock protein A
JOS67_RS09290	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JOS67_RS09305	COG4171	peptide transport system, permease
JOS67_RS09315	COG4172	Belongs to the ABC transporter superfamily
JOS67_RS09325	COG1227	inorganic diphosphatase activity
JOS67_RS09340	COG0243	molybdopterin cofactor binding
JOS67_RS09345	COG3005	denitrification pathway
JOS67_RS09350	COG4459	periplasmic nitrate reductase
JOS67_RS09355	COG0390	transport system, permease component
JOS67_RS09365	COG2116	formate transmembrane transporter activity
JOS67_RS09390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JOS67_RS09395	COG1435	thymidine kinase activity
JOS67_RS09400	COG0215	cysteine-tRNA ligase activity
JOS67_RS09405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JOS67_RS09410	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JOS67_RS09415	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JOS67_RS09420	COG3012	SEC-C Motif Domain Protein
JOS67_RS09425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JOS67_RS09425	COG0140	phosphoribosyl-ATP diphosphatase activity
JOS67_RS09435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JOS67_RS09440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JOS67_RS09445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JOS67_RS09445	COG0131	Imidazoleglycerol-phosphate dehydratase
JOS67_RS09450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JOS67_RS09455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JOS67_RS09460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JOS67_RS09470	COG1757	Na H antiporter
JOS67_RS09480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JOS67_RS09490	COG0482	sulfurtransferase activity
JOS67_RS09495	COG2915	High frequency lysogenization protein hflD homolog
JOS67_RS09500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JOS67_RS09510	COG2268	Band 7 protein
JOS67_RS09520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JOS67_RS09535	COG0300	oxidoreductase activity
JOS67_RS09555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JOS67_RS09560	COG2226	methyltransferase
JOS67_RS09560	COG1073	alpha beta
JOS67_RS09595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JOS67_RS09605	COG1674	ftsk spoiiie
JOS67_RS09615	COG0686	Belongs to the AlaDH PNT family
JOS67_RS09625	COG0583	DNA-binding transcription factor activity
JOS67_RS09640	COG0840	transmembrane signaling receptor activity
JOS67_RS09650	COG3568	Endonuclease Exonuclease Phosphatase
JOS67_RS09675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JOS67_RS09680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS09685	COG0840	transmembrane signaling receptor activity
JOS67_RS09700	COG5002	protein histidine kinase activity
JOS67_RS09700	COG0784	Response regulator, receiver
JOS67_RS09710	COG0754	glutathionylspermidine amidase activity
JOS67_RS09720	COG3766	membrane
JOS67_RS09730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JOS67_RS09735	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JOS67_RS09740	COG2885	chlorophyll binding
JOS67_RS09745	COG0823	Involved in the tonB-independent uptake of proteins
JOS67_RS09760	COG0811	peptide transport
JOS67_RS09765	COG0824	Thioesterase
JOS67_RS09775	COG4890	Cyd operon protein YbgT
JOS67_RS09780	COG1294	oxidase, subunit
JOS67_RS09785	COG1271	oxidase subunit
JOS67_RS09790	COG2255	four-way junction helicase activity
JOS67_RS09795	COG0632	four-way junction helicase activity
JOS67_RS09800	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JOS67_RS09805	COG0217	transcriptional regulatory protein
JOS67_RS09815	COG1801	Protein of unknown function DUF72
JOS67_RS09825	COG0500	methyltransferase
JOS67_RS09830	COG0189	ligase activity
JOS67_RS09830	COG4067	protein conserved in archaea
JOS67_RS09850	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JOS67_RS09855	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JOS67_RS09860	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
JOS67_RS09865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JOS67_RS09870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JOS67_RS09875	COG0745	RESPONSE REGULATOR receiver
JOS67_RS09880	COG3381	protein complex oligomerization
JOS67_RS09885	COG1609	Transcriptional regulator
JOS67_RS09890	COG3070	regulator of competence-specific genes
JOS67_RS09910	COG0297	glycogen (starch) synthase activity
JOS67_RS09915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JOS67_RS09920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JOS67_RS09940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JOS67_RS09945	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JOS67_RS09950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JOS67_RS09955	COG0542	response to heat
JOS67_RS09960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JOS67_RS09965	COG1278	Cold shock
JOS67_RS09975	COG1187	pseudouridine synthase activity
JOS67_RS09980	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JOS67_RS09990	COG1199	ATP-dependent helicase activity
JOS67_RS09995	COG0730	response to heat
JOS67_RS10000	COG3923	Primosomal replication protein n
JOS67_RS10010	COG0708	Exodeoxyribonuclease III
JOS67_RS10050	COG1882	Formate acetyltransferase
JOS67_RS10060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JOS67_RS10070	COG3013	Belongs to the UPF0304 family
JOS67_RS10075	COG2766	serine protein kinase
JOS67_RS10080	COG2718	Belongs to the UPF0229 family
JOS67_RS10085	COG2719	SpoVR family
JOS67_RS10105	COG1132	(ABC) transporter
JOS67_RS10110	COG2333	competence protein COMEC
JOS67_RS10110	COG0658	competence protein
JOS67_RS10120	COG4591	ABC-type transport system involved in lipoprotein release permease component
JOS67_RS10125	COG1136	(ABC) transporter
JOS67_RS10130	COG4591	ABC-type transport system involved in lipoprotein release permease component
JOS67_RS10140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JOS67_RS10155	COG1252	NADH dehydrogenase
JOS67_RS10160	COG3150	esterase
JOS67_RS10185	COG0537	adenosine 5'-monophosphoramidase activity
JOS67_RS10210	COG0516	GMP reductase activity
JOS67_RS10210	COG0517	IMP dehydrogenase activity
JOS67_RS10215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JOS67_RS10240	COG3126	Type III secretion system lipoprotein chaperone (YscW)
JOS67_RS10245	COG1946	Acyl-CoA thioesterase
JOS67_RS10255	COG1522	sequence-specific DNA binding
JOS67_RS10280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JOS67_RS10285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS10330	COG0477	Major facilitator Superfamily
JOS67_RS10335	COG2855	membrane
JOS67_RS10355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JOS67_RS10360	COG0596	Alpha beta hydrolase
JOS67_RS10365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JOS67_RS10370	COG1169	isochorismate synthase
JOS67_RS10375	COG0436	Aminotransferase
JOS67_RS10380	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JOS67_RS10385	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JOS67_RS10400	COG1555	photosystem II stabilization
JOS67_RS10405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JOS67_RS10410	COG0776	regulation of translation
JOS67_RS10415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JOS67_RS10420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JOS67_RS10430	COG0544	peptidyl-prolyl cis-trans isomerase activity
JOS67_RS10445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JOS67_RS10450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JOS67_RS10455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JOS67_RS10460	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JOS67_RS10475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JOS67_RS10480	COG0569	domain protein
JOS67_RS10485	COG0513	Belongs to the DEAD box helicase family
JOS67_RS10490	COG1253	flavin adenine dinucleotide binding
JOS67_RS10525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JOS67_RS10530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JOS67_RS10545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JOS67_RS10550	COG1216	Glycosyl transferase, family 2
JOS67_RS10555	COG2986	histidine ammonia-lyase
JOS67_RS10580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JOS67_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS10600	COG2226	methyltransferase
JOS67_RS10610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JOS67_RS10615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JOS67_RS10625	COG2951	lytic endotransglycosylase activity
JOS67_RS10630	COG3100	YcgL domain-containing protein
JOS67_RS10635	COG0850	regulation of cytokinetic process
JOS67_RS10640	COG2894	cell division
JOS67_RS10645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JOS67_RS10650	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JOS67_RS10655	COG0318	PFAM AMP-dependent synthetase and ligase
JOS67_RS10660	COG2267	carboxylic ester hydrolase activity
JOS67_RS10665	COG3065	identical protein binding
JOS67_RS10675	COG1214	PFAM Peptidase M22, glycoprotease
JOS67_RS10680	COG1199	ATP-dependent helicase activity
JOS67_RS10685	COG0788	formyltetrahydrofolate deformylase activity
JOS67_RS10700	COG3102	Protein conserved in bacteria
JOS67_RS10705	COG0018	arginyl-trna synthetase
JOS67_RS10725	COG1918	ferrous iron import across plasma membrane
JOS67_RS10730	COG4977	sequence-specific DNA binding
JOS67_RS10735	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JOS67_RS10740	COG1121	(ABC) transporter
JOS67_RS10745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JOS67_RS10760	COG0508	dehydrogenase complex catalyzes the overall conversion of
JOS67_RS10765	COG0567	Dehydrogenase, E1 component
JOS67_RS10770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JOS67_RS10775	COG1053	succinate dehydrogenase
JOS67_RS10780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JOS67_RS10795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JOS67_RS10805	COG0033	Phosphoglucomutase
JOS67_RS10810	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JOS67_RS10815	COG0596	Alpha beta hydrolase
JOS67_RS10825	COG0716	FMN binding
JOS67_RS10835	COG0735	belongs to the Fur family
JOS67_RS10840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JOS67_RS10845	COG1263	PTS System
JOS67_RS10845	COG2190	(PTS) system
JOS67_RS10845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS10850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JOS67_RS10855	COG1940	carbohydrate kinase activity
JOS67_RS10855	COG1846	Transcriptional regulator
JOS67_RS10860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JOS67_RS10860	COG4651	solute:proton antiporter activity
JOS67_RS10865	COG0367	asparagine synthase
JOS67_RS10870	COG0250	Participates in transcription elongation, termination and antitermination
JOS67_RS10875	COG3104	oligopeptide transport
JOS67_RS10880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JOS67_RS10890	COG0326	Molecular chaperone. Has ATPase activity
JOS67_RS10895	COG3710	Transcriptional regulator
JOS67_RS10915	COG0622	Phosphoesterase
JOS67_RS10945	COG1090	epimerase
JOS67_RS10950	COG0300	oxidoreductase activity
JOS67_RS10955	COG3118	belongs to the thioredoxin family
JOS67_RS10960	COG0330	HflC and HflK could
JOS67_RS10980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JOS67_RS10985	COG3115	cell septum assembly
JOS67_RS10990	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
JOS67_RS10995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JOS67_RS11000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS11005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JOS67_RS11010	COG2190	(PTS) system
JOS67_RS11015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS11020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS11025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS11035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS11045	COG1705	Flagellar rod assembly protein muramidase FlgJ
JOS67_RS11045	COG3951	Flagellar rod assembly protein muramidase FlgJ
JOS67_RS11050	COG1706	bacterial-type flagellum-dependent cell motility
JOS67_RS11055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JOS67_RS11065	COG4787	bacterial-type flagellum-dependent cell motility
JOS67_RS11070	COG1749	Flagellar hook protein flgE
JOS67_RS11080	COG1558	bacterial-type flagellum-dependent cell motility
JOS67_RS11085	COG1815	bacterial-type flagellum-dependent cell motility
JOS67_RS11090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JOS67_RS11095	COG0835	chemotaxis
JOS67_RS11095	COG0784	Response regulator, receiver
JOS67_RS11150	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JOS67_RS11160	COG2217	Heavy metal translocating P-type atpase
JOS67_RS11160	COG2608	mercury ion transmembrane transporter activity
JOS67_RS11200	COG2840	Smr protein MutS2
JOS67_RS11205	COG1187	pseudouridine synthase activity
JOS67_RS11210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JOS67_RS11215	COG0737	Belongs to the 5'-nucleotidase family
JOS67_RS11220	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JOS67_RS11225	COG2912	Transglutaminase-like superfamily
JOS67_RS11230	COG3094	Invasion gene expression up-regulator, SirB
JOS67_RS11235	COG2890	protein-(glutamine-N5) methyltransferase activity
JOS67_RS11240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JOS67_RS11245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JOS67_RS11250	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JOS67_RS11255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JOS67_RS11260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JOS67_RS11265	COG0193	aminoacyl-tRNA hydrolase activity
JOS67_RS11270	COG0012	GTP binding
JOS67_RS11370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JOS67_RS11375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JOS67_RS11380	COG1702	phosphate starvation-inducible protein PhoH
JOS67_RS11385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JOS67_RS11390	COG4535	Mg2 and Co2 transporter CorC
JOS67_RS11395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JOS67_RS11400	COG2888	peptidyl-tyrosine sulfation
JOS67_RS11405	COG0495	leucyl-tRNA aminoacylation
JOS67_RS11410	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JOS67_RS11415	COG1466	dna polymerase III delta subunit
JOS67_RS11420	COG0799	negative regulation of ribosome biogenesis
JOS67_RS11425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JOS67_RS11430	COG0768	penicillin binding
JOS67_RS11435	COG0772	Belongs to the SEDS family
JOS67_RS11440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JOS67_RS11445	COG1686	Belongs to the peptidase S11 family
JOS67_RS11455	COG0321	lipoyl(octanoyl) transferase activity
JOS67_RS11460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JOS67_RS11465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JOS67_RS11470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JOS67_RS11485	COG0366	Alpha amylase catalytic
JOS67_RS11490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS11490	COG1263	PTS System
JOS67_RS11500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JOS67_RS11505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JOS67_RS11510	COG2011	ABC-type metal ion transport system permease component
JOS67_RS11515	COG1464	Belongs to the NlpA lipoprotein family
JOS67_RS11520	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JOS67_RS11530	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JOS67_RS11530	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JOS67_RS11545	COG1611	Belongs to the LOG family
JOS67_RS11550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JOS67_RS11560	COG2363	Small membrane protein
JOS67_RS11570	COG0583	DNA-binding transcription factor activity
JOS67_RS11575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JOS67_RS11575	COG0301	tRNA thio-modification
JOS67_RS11585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JOS67_RS11590	COG1722	exodeoxyribonuclease VII activity
JOS67_RS11595	COG0142	geranyltranstransferase activity
JOS67_RS11600	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JOS67_RS11605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JOS67_RS11610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JOS67_RS11620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JOS67_RS11635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JOS67_RS11635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JOS67_RS11640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JOS67_RS11645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JOS67_RS11650	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JOS67_RS11660	COG1073	alpha beta
JOS67_RS11665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JOS67_RS11670	COG2252	PERMEase
JOS67_RS11675	COG2195	Cleaves the N-terminal amino acid of tripeptides
JOS67_RS11690	COG1629	transport
JOS67_RS11705	COG0047	phosphoribosylformylglycinamidine synthase activity
JOS67_RS11705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JOS67_RS11710	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JOS67_RS11720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JOS67_RS11740	COG4969	Belongs to the N-Me-Phe pilin family
JOS67_RS11750	COG0484	heat shock protein binding
JOS67_RS11760	COG1301	dicarboxylic acid transport
JOS67_RS11765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JOS67_RS11770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JOS67_RS11780	COG0497	DNA recombination
JOS67_RS11785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JOS67_RS11790	COG2914	Belongs to the UPF0125 (RnfH) family
JOS67_RS11795	COG2867	negative regulation of translational initiation
JOS67_RS11800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JOS67_RS11815	COG0583	DNA-binding transcription factor activity
JOS67_RS11820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JOS67_RS11820	COG3153	acetyltransferase
JOS67_RS11840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JOS67_RS11845	COG2873	o-acetylhomoserine
JOS67_RS11865	COG1115	amino acid carrier protein
JOS67_RS11870	COG1584	GPR1 FUN34 yaaH family protein
JOS67_RS11880	COG1757	Na H antiporter
JOS67_RS11910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JOS67_RS11915	COG3710	Transcriptional regulator
JOS67_RS11960	COG0582	viral genome integration into host DNA
JOS67_RS11965	COG0519	Catalyzes the synthesis of GMP from XMP
JOS67_RS11965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JOS67_RS11970	COG0517	IMP dehydrogenase activity
JOS67_RS11970	COG0516	GMP reductase activity
JOS67_RS11990	COG1160	GTP binding
JOS67_RS11995	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JOS67_RS12000	COG2976	Protein conserved in bacteria
JOS67_RS12005	COG0124	histidyl-tRNA synthetase
JOS67_RS12010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JOS67_RS12025	COG0105	UTP biosynthetic process
JOS67_RS12035	COG2975	iron-sulfur cluster assembly
JOS67_RS12040	COG0633	Ferredoxin
JOS67_RS12045	COG0443	Heat shock 70 kDa protein
JOS67_RS12060	COG0822	iron-sulfur transferase activity
JOS67_RS12065	COG1104	cysteine desulfurase activity
JOS67_RS12075	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JOS67_RS12080	COG0483	inositol monophosphate 1-phosphatase activity
JOS67_RS12085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JOS67_RS12090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JOS67_RS12095	COG1862	Preprotein translocase
JOS67_RS12105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JOS67_RS12115	COG0517	IMP dehydrogenase activity
JOS67_RS12125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JOS67_RS12130	COG0583	DNA-binding transcription factor activity
JOS67_RS12135	COG0450	alkyl hydroperoxide reductase
JOS67_RS12140	COG3142	Participates in the control of copper homeostasis
JOS67_RS12150	COG0704	Plays a role in the regulation of phosphate uptake
JOS67_RS12155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JOS67_RS12160	COG0581	inorganic phosphate transmembrane transporter activity
JOS67_RS12170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JOS67_RS12175	COG0248	Ppx GppA phosphatase
JOS67_RS12185	COG5002	protein histidine kinase activity
JOS67_RS12190	COG0745	RESPONSE REGULATOR receiver
JOS67_RS12195	COG2974	May be involved in recombination
JOS67_RS12200	COG0826	peptidase U32
JOS67_RS12205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JOS67_RS12260	COG0542	response to heat
JOS67_RS12270	COG0564	pseudouridine synthase activity
JOS67_RS12275	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JOS67_RS12280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JOS67_RS12285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JOS67_RS12290	COG0077	Prephenate dehydratase
JOS67_RS12290	COG1605	Chorismate mutase
JOS67_RS12295	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
JOS67_RS12300	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
JOS67_RS12310	COG0488	(ABC) transporter
JOS67_RS12320	COG0739	heme binding
JOS67_RS12320	COG0741	lytic transglycosylase activity
JOS67_RS12320	COG1196	nuclear chromosome segregation
JOS67_RS12325	COG0287	Prephenate dehydrogenase
JOS67_RS12325	COG1605	Chorismate mutase
JOS67_RS12330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JOS67_RS12335	COG1472	Belongs to the glycosyl hydrolase 3 family
JOS67_RS12340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JOS67_RS12360	COG1966	Carbon starvation protein
JOS67_RS12365	COG3275	phosphorelay sensor kinase activity
JOS67_RS12370	COG3279	Response regulator of the LytR AlgR family
JOS67_RS12380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JOS67_RS12385	COG1047	Peptidyl-prolyl cis-trans
JOS67_RS12390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JOS67_RS12400	COG0196	riboflavin kinase activity
JOS67_RS12405	COG0728	peptidoglycan biosynthetic process
JOS67_RS12410	COG0268	Binds directly to 16S ribosomal RNA
JOS67_RS12415	COG0640	Transcriptional regulator
JOS67_RS12420	COG0583	DNA-binding transcription factor activity
JOS67_RS12425	COG1283	sodium-dependent phosphate transmembrane transporter activity
JOS67_RS12435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JOS67_RS12440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JOS67_RS12445	COG0730	response to heat
JOS67_RS12470	COG0667	Aldo Keto reductase
JOS67_RS12480	COG2204	response regulator
JOS67_RS12485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JOS67_RS12495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JOS67_RS12500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JOS67_RS12505	COG4974	Belongs to the 'phage' integrase family
JOS67_RS12510	COG0716	FMN binding
JOS67_RS12520	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JOS67_RS12525	COG0513	Belongs to the DEAD box helicase family
JOS67_RS12530	COG3022	response to hydroperoxide
JOS67_RS12535	COG1115	amino acid carrier protein
JOS67_RS12550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JOS67_RS12555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JOS67_RS12560	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JOS67_RS12570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JOS67_RS12575	COG0083	homoserine kinase activity
JOS67_RS12595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JOS67_RS12605	COG0745	RESPONSE REGULATOR receiver
JOS67_RS12615	COG0784	Response regulator, receiver
JOS67_RS12615	COG2198	Histidine kinase
JOS67_RS12615	COG5002	protein histidine kinase activity
JOS67_RS12620	COG2203	Gaf domain
JOS67_RS12620	COG3706	GGDEF domain
JOS67_RS12620	COG4251	negative regulation of phosphorylation
JOS67_RS12620	COG5001	Diguanylate cyclase
JOS67_RS12625	COG1242	4 iron, 4 sulfur cluster binding
JOS67_RS12630	COG0070	glutamate synthase
JOS67_RS12630	COG0067	glutamate synthase
JOS67_RS12630	COG0069	glutamate synthase activity
JOS67_RS12640	COG0070	glutamate synthase
JOS67_RS12640	COG0069	glutamate synthase activity
JOS67_RS12640	COG0067	glutamate synthase
JOS67_RS12645	COG0493	'glutamate synthase
JOS67_RS12655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JOS67_RS12670	COG2860	membrane
JOS67_RS12675	COG0583	DNA-binding transcription factor activity
JOS67_RS12690	COG0730	response to heat
JOS67_RS12705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JOS67_RS12710	COG0505	Belongs to the CarA family
JOS67_RS12725	COG0494	nUDIX hydrolase
JOS67_RS12730	COG0653	protein targeting
JOS67_RS12740	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JOS67_RS12745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JOS67_RS12750	COG0849	cell division
JOS67_RS12755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JOS67_RS12760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JOS67_RS12770	COG0772	Belongs to the SEDS family
JOS67_RS12775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JOS67_RS12780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JOS67_RS12785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JOS67_RS12790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JOS67_RS12795	COG0768	penicillin binding
JOS67_RS12800	COG3116	cell division
JOS67_RS12815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JOS67_RS12830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JOS67_RS12835	COG2823	Periplasmic or secreted lipoprotein
JOS67_RS12840	COG2969	positive regulation of protein catabolic process
JOS67_RS12845	COG0625	glutathione transferase activity
JOS67_RS12850	COG2857	Cytochrome c1
JOS67_RS12855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JOS67_RS12860	COG0723	plastoquinol--plastocyanin reductase activity
JOS67_RS12865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JOS67_RS12870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JOS67_RS12875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JOS67_RS12880	COG3105	Protein conserved in bacteria
JOS67_RS12890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JOS67_RS12905	COG3150	esterase
JOS67_RS12915	COG3151	Protein conserved in bacteria
JOS67_RS12920	COG0494	nUDIX hydrolase
JOS67_RS12925	COG1538	Outer membrane efflux protein
JOS67_RS12930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JOS67_RS12930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JOS67_RS12935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JOS67_RS12950	COG3025	triphosphatase activity
JOS67_RS12955	COG1392	Phosphate transport regulator
JOS67_RS12960	COG0306	phosphate transporter
JOS67_RS12965	COG4991	sh3 domain protein
JOS67_RS12970	COG0405	Gamma-glutamyltransferase
JOS67_RS12980	COG3267	Type II secretory pathway component ExeA
JOS67_RS12980	COG3409	Peptidoglycan-binding domain 1 protein
JOS67_RS12985	COG0617	tRNA 3'-terminal CCA addition
JOS67_RS12990	COG1968	undecaprenyl-diphosphatase activity
JOS67_RS12995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JOS67_RS13000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JOS67_RS13005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JOS67_RS13010	COG0596	Alpha beta hydrolase
JOS67_RS13015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JOS67_RS13020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JOS67_RS13025	COG1610	YqeY-like protein
JOS67_RS13030	COG0358	DNA primase activity
JOS67_RS13045	COG1464	Belongs to the NlpA lipoprotein family
JOS67_RS13075	COG2213	PTS system mannitol-specific
JOS67_RS13075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS13080	COG0246	Mannitol dehydrogenase
JOS67_RS13085	COG3722	fumarate hydratase activity
JOS67_RS13100	COG1461	Dihydroxyacetone kinase
JOS67_RS13105	COG2376	Dihydroxyacetone kinase
JOS67_RS13115	COG5002	protein histidine kinase activity
JOS67_RS13130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JOS67_RS13135	COG1349	DNA-binding transcription factor activity
JOS67_RS13140	COG0469	pyruvate kinase activity
JOS67_RS13160	COG0028	Belongs to the TPP enzyme family
JOS67_RS13170	COG1022	Amp-dependent synthetase and ligase
JOS67_RS13175	COG0583	DNA-binding transcription factor activity
JOS67_RS13195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JOS67_RS13200	COG0473	3-isopropylmalate dehydrogenase activity
JOS67_RS13220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JOS67_RS13225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JOS67_RS13230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JOS67_RS13235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JOS67_RS13240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JOS67_RS13245	COG2967	ApaG domain
JOS67_RS13250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JOS67_RS13265	COG2966	Psort location CytoplasmicMembrane, score
JOS67_RS13270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JOS67_RS13280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JOS67_RS13285	COG0142	geranyltranstransferase activity
JOS67_RS13305	COG2358	TRAP transporter, solute receptor (TAXI family
JOS67_RS13320	COG1902	pentaerythritol trinitrate reductase activity
JOS67_RS13325	COG0583	DNA-binding transcription factor activity
JOS67_RS13330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JOS67_RS13335	COG1178	ABC-type Fe3 transport system permease component
JOS67_RS13340	COG4143	(ABC) transporter
JOS67_RS13345	COG0163	prenyltransferase activity
JOS67_RS13350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JOS67_RS13355	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JOS67_RS13360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JOS67_RS13370	COG2105	PFAM AIG2 family protein
JOS67_RS13375	COG2911	Protein conserved in bacteria
JOS67_RS13380	COG0729	surface antigen
JOS67_RS13385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JOS67_RS13395	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JOS67_RS13410	COG4181	ATPase activity
JOS67_RS13430	COG0529	Catalyzes the synthesis of activated sulfate
JOS67_RS13435	COG0471	metal ion transport
JOS67_RS13435	COG3273	potassium ion transport
JOS67_RS13440	COG2895	sulfate adenylyltransferase (ATP) activity
JOS67_RS13445	COG0175	sulfate reduction
JOS67_RS13450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JOS67_RS13450	COG1648	precorrin-2 dehydrogenase activity
JOS67_RS13465	COG0513	Belongs to the DEAD box helicase family
JOS67_RS13470	COG2153	protein acetylation
JOS67_RS13480	COG0545	Peptidyl-prolyl cis-trans isomerase
JOS67_RS13490	COG0203	ribosomal protein L17
JOS67_RS13495	COG0202	RNA polymerase activity
JOS67_RS13505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JOS67_RS13510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JOS67_RS13515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JOS67_RS13520	COG0201	protein transport
JOS67_RS13525	COG0200	Binds to the 23S rRNA
JOS67_RS13530	COG1841	ribosomal large subunit assembly
JOS67_RS13545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JOS67_RS13550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JOS67_RS13560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JOS67_RS13565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JOS67_RS13575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JOS67_RS13580	COG0255	Belongs to the universal ribosomal protein uL29 family
JOS67_RS13590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JOS67_RS13595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JOS67_RS13600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JOS67_RS13605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JOS67_RS13615	COG0088	Forms part of the polypeptide exit tunnel
JOS67_RS13620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JOS67_RS13630	COG0254	rRNA binding
JOS67_RS13635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JOS67_RS13640	COG1609	Transcriptional regulator
JOS67_RS13670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JOS67_RS13675	COG1575	Belongs to the MenA family. Type 1 subfamily
JOS67_RS13680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JOS67_RS13690	COG1494	fructose-1,6-bisphosphatase
JOS67_RS13720	COG0149	triose-phosphate isomerase activity
JOS67_RS13765	COG3550	peptidyl-serine autophosphorylation
JOS67_RS13860	COG5433	transposase activity
JOS67_RS13865	COG5433	transposase activity
JOS67_RS13885	COG1086	Polysaccharide biosynthesis protein
JOS67_RS13895	COG0438	transferase activity, transferring glycosyl groups
JOS67_RS13900	COG0438	transferase activity, transferring glycosyl groups
JOS67_RS13905	COG5433	transposase activity
JOS67_RS13925	COG1560	Kdo2-lipid A biosynthetic process
JOS67_RS13935	COG0859	PFAM glycosyl transferase family 9
JOS67_RS13940	COG1519	Transferase
JOS67_RS13945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JOS67_RS13950	COG0110	maltose O-acetyltransferase activity
JOS67_RS13960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JOS67_RS13975	COG3642	lipopolysaccharide core region biosynthetic process
JOS67_RS13980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JOS67_RS13985	COG0438	transferase activity, transferring glycosyl groups
JOS67_RS13990	COG0859	PFAM glycosyl transferase family 9
JOS67_RS14035	COG2003	Belongs to the UPF0758 family
JOS67_RS14040	COG0840	transmembrane signaling receptor activity
JOS67_RS14045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JOS67_RS14050	COG1309	transcriptional regulator
JOS67_RS14055	COG1560	Kdo2-lipid A biosynthetic process
JOS67_RS14060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JOS67_RS14065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JOS67_RS14070	COG1561	YicC-like family, N-terminal region
JOS67_RS14080	COG4608	Belongs to the ABC transporter superfamily
JOS67_RS14085	COG0444	Belongs to the ABC transporter superfamily
JOS67_RS14090	COG0747	negative chemotaxis
JOS67_RS14095	COG4239	(ABC) transporter, permease
JOS67_RS14100	COG4174	ABC transporter (Permease)
JOS67_RS14120	COG0811	peptide transport
JOS67_RS14125	COG0848	biopolymer transport protein
JOS67_RS14140	COG0194	GDP metabolic process
JOS67_RS14145	COG1758	RNA polymerase activity
JOS67_RS14150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JOS67_RS14155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JOS67_RS14160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JOS67_RS14165	COG2233	PERMEase
JOS67_RS14185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JOS67_RS14195	COG2183	response to ionizing radiation
JOS67_RS14210	COG1040	competence protein
JOS67_RS14220	COG0494	nUDIX hydrolase
JOS67_RS14225	COG1218	3'(2'),5'-bisphosphate nucleotidase
JOS67_RS14235	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JOS67_RS14240	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JOS67_RS14245	COG3156	type II secretion system protein K
JOS67_RS14250	COG4795	General secretion pathway protein
JOS67_RS14255	COG2165	general secretion pathway protein
JOS67_RS14260	COG2165	general secretion pathway protein
JOS67_RS14265	COG2165	general secretion pathway protein
JOS67_RS14270	COG1459	type II secretion system
JOS67_RS14275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JOS67_RS14285	COG3031	protein transport across the cell outer membrane
JOS67_RS14290	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JOS67_RS14295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JOS67_RS14300	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JOS67_RS14310	COG0456	acetyltransferase
JOS67_RS14315	COG1490	D-aminoacyl-tRNA deacylase activity
JOS67_RS14320	COG1295	ribonuclease BN
JOS67_RS14335	COG1217	gtp-binding protein TYPA
JOS67_RS14340	COG0174	glutamine synthetase
JOS67_RS14350	COG3852	Histidine kinase
JOS67_RS14355	COG2204	response regulator
JOS67_RS14365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JOS67_RS14395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JOS67_RS14400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JOS67_RS14400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JOS67_RS14405	COG0456	acetyltransferase
JOS67_RS14415	COG0084	hydrolase, TatD family'
JOS67_RS14420	COG0805	protein transport
JOS67_RS14425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JOS67_RS14435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JOS67_RS14440	COG3165	ubiquinone biosynthetic process from chorismate
JOS67_RS14445	COG2226	methyltransferase
JOS67_RS14450	COG1322	Protein conserved in bacteria
JOS67_RS14465	COG0628	permease
JOS67_RS14495	COG1597	lipid kinase activity
JOS67_RS14520	COG2204	response regulator
JOS67_RS14525	COG2081	HI0933 family
JOS67_RS14535	COG1528	Iron-storage protein
JOS67_RS14540	COG0589	response to stress
JOS67_RS14555	COG0742	ribosomal rna small subunit methyltransferase
JOS67_RS14560	COG5002	protein histidine kinase activity
JOS67_RS14560	COG5001	Diguanylate cyclase
JOS67_RS14565	COG1522	sequence-specific DNA binding
JOS67_RS14575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JOS67_RS14580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JOS67_RS14610	COG0583	DNA-binding transcription factor activity
JOS67_RS14615	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JOS67_RS14620	COG0800	Aldolase
JOS67_RS14625	COG2610	gluconate transmembrane transporter activity
JOS67_RS14630	COG3265	gluconokinase activity
JOS67_RS14635	COG0129	dihydroxy-acid dehydratase activity
JOS67_RS14650	COG0583	DNA-binding transcription factor activity
JOS67_RS14655	COG1609	Transcriptional regulator
JOS67_RS14695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JOS67_RS14700	COG0601	transmembrane transport
JOS67_RS14705	COG4166	transmembrane transport
JOS67_RS14760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS14765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JOS67_RS14770	COG2960	long-chain fatty acid transporting porin activity
JOS67_RS14775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JOS67_RS14780	COG0583	DNA-binding transcription factor activity
JOS67_RS14820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JOS67_RS14830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JOS67_RS14835	COG0408	coproporphyrinogen oxidase activity
JOS67_RS14840	COG0009	L-threonylcarbamoyladenylate synthase
JOS67_RS14845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JOS67_RS14850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JOS67_RS14855	COG0551	DNA topoisomerase type I activity
JOS67_RS14860	COG2922	Belongs to the Smg family
JOS67_RS14865	COG0758	DNA mediated transformation
JOS67_RS14875	COG0242	peptide deformylase activity
JOS67_RS14880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JOS67_RS14885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JOS67_RS14885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JOS67_RS14890	COG0569	domain protein
JOS67_RS14895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JOS67_RS14905	COG1272	protein, Hemolysin III
JOS67_RS14910	COG4326	sporulation control protein
JOS67_RS14920	COG3084	Protein conserved in bacteria
JOS67_RS14930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JOS67_RS14935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JOS67_RS14940	COG0204	Acyl-transferase
JOS67_RS14955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JOS67_RS14975	COG0606	chelatase, subunit chli
JOS67_RS14985	COG3978	acetolactate synthase activity
JOS67_RS14990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JOS67_RS14995	COG0129	dihydroxy-acid dehydratase activity
JOS67_RS15005	COG0583	DNA-binding transcription factor activity
JOS67_RS15010	COG2814	Major facilitator Superfamily
JOS67_RS15020	COG0765	amino acid transport
JOS67_RS15030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JOS67_RS15035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JOS67_RS15040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JOS67_RS15045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JOS67_RS15050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JOS67_RS15055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JOS67_RS15065	COG0356	it plays a direct role in the translocation of protons across the membrane
JOS67_RS15070	COG3312	ion transport
JOS67_RS15075	COG1475	DNA binding
JOS67_RS15080	COG1192	Involved in chromosome partitioning
JOS67_RS15085	COG0357	Ribosomal RNA small subunit methyltransferase G
JOS67_RS15090	COG0445	tRNA wobble uridine modification
JOS67_RS15095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JOS67_RS15110	COG1395	domain, Protein
JOS67_RS15145	COG0482	sulfurtransferase activity
JOS67_RS15175	COG0419	ATPase involved in DNA repair
JOS67_RS15185	COG1104	cysteine desulfurase activity
JOS67_RS15210	COG4974	Belongs to the 'phage' integrase family
JOS67_RS15220	COG0706	membrane insertase activity
JOS67_RS15230	COG0594	ribonuclease P activity
JOS67_RS15240	COG1126	abc transporter atp-binding protein
JOS67_RS15650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JOS67_RS15835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS15900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JOS67_RS16155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JOS67_RS16230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JOS67_RS16235	COG0402	S-adenosylhomocysteine deaminase activity
JOS67_RS16240	COG1418	mRNA catabolic process
JOS67_RS16250	COG2814	Major facilitator Superfamily
JOS67_RS16260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JOS67_RS16280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JOS67_RS16295	COG0745	RESPONSE REGULATOR receiver
JOS67_RS16300	COG2205	protein histidine kinase activity
JOS67_RS16310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JOS67_RS16315	COG2194	sulfuric ester hydrolase activity
JOS67_RS16335	COG4667	esterase of the alpha-beta hydrolase superfamily
JOS67_RS16340	COG1741	Belongs to the pirin family
JOS67_RS16345	COG1278	Cold shock
JOS67_RS16360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JOS67_RS16375	COG1686	Belongs to the peptidase S11 family
JOS67_RS16380	COG0625	glutathione transferase activity
JOS67_RS16385	COG1621	beta-fructofuranosidase activity
JOS67_RS16390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JOS67_RS16395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS16395	COG1263	PTS System
JOS67_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS16430	COG3746	phosphate-selective porin O and P
JOS67_RS16450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JOS67_RS16450	COG2207	Transcriptional regulator
JOS67_RS16455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JOS67_RS16480	COG1063	alcohol dehydrogenase
JOS67_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS16495	COG2207	Transcriptional regulator
JOS67_RS16500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JOS67_RS16505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JOS67_RS16510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JOS67_RS16515	COG0006	proline dipeptidase activity
JOS67_RS16520	COG3608	succinylglutamate desuccinylase aspartoacylase
JOS67_RS16530	COG1522	sequence-specific DNA binding
JOS67_RS16535	COG1012	belongs to the aldehyde dehydrogenase family
JOS67_RS16540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JOS67_RS16545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JOS67_RS16550	COG2423	ornithine cyclodeaminase activity
JOS67_RS16560	COG3122	Protein conserved in bacteria
JOS67_RS16565	COG1280	lysine exporter protein (LysE YggA)
JOS67_RS16575	COG0583	DNA-binding transcription factor activity
JOS67_RS16580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JOS67_RS16590	COG0252	asparaginase activity
JOS67_RS16595	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JOS67_RS16610	COG2197	response regulator
JOS67_RS16615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JOS67_RS16630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS16655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JOS67_RS16685	COG3842	ATPase activity
JOS67_RS16725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JOS67_RS16760	COG0583	DNA-binding transcription factor activity
JOS67_RS16770	COG4948	Mandelate Racemase Muconate Lactonizing
JOS67_RS16800	COG1342	Belongs to the UPF0251 family
JOS67_RS16805	COG4176	ABC-type proline glycine betaine transport system permease component
JOS67_RS16810	COG4175	Glycine betaine
JOS67_RS16810	COG3448	diguanylate cyclase activity
JOS67_RS16815	COG3015	lipoprotein NlpE involved in copper resistance
JOS67_RS16820	COG3713	MltA-interacting MipA family protein
JOS67_RS16835	COG0583	DNA-binding transcription factor activity
JOS67_RS16860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JOS67_RS16870	COG1335	isochorismatase
JOS67_RS16880	COG1349	DNA-binding transcription factor activity
JOS67_RS16885	COG0346	lactoylglutathione lyase activity
JOS67_RS16900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS67_RS16905	COG2070	2-Nitropropane dioxygenase
JOS67_RS16910	COG0531	amino acid
JOS67_RS16915	COG4302	ethanolamine ammonia-lyase activity
JOS67_RS16920	COG4303	Ethanolamine ammonia lyase large subunit
JOS67_RS16925	COG2207	Transcriptional regulator
JOS67_RS16930	COG1309	transcriptional regulator
JOS67_RS16960	COG0459	protein refolding
JOS67_RS16965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JOS67_RS16970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JOS67_RS16985	COG1304	FMN binding
JOS67_RS17005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS17010	COG4786	Flagellar basal body rod
JOS67_RS17010	COG1256	bacterial-type flagellum assembly
JOS67_RS17020	COG1706	bacterial-type flagellum-dependent cell motility
JOS67_RS17025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JOS67_RS17030	COG4786	Flagellar basal body rod
JOS67_RS17035	COG4787	bacterial-type flagellum-dependent cell motility
JOS67_RS17040	COG1749	Flagellar hook protein flgE
JOS67_RS17045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JOS67_RS17050	COG1558	bacterial-type flagellum-dependent cell motility
JOS67_RS17055	COG1815	bacterial-type flagellum-dependent cell motility
JOS67_RS17075	COG0741	lytic transglycosylase activity
JOS67_RS17080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JOS67_RS17100	COG1760	l-serine dehydratase
JOS67_RS17105	COG3104	oligopeptide transport
JOS67_RS17125	COG0583	DNA-binding transcription factor activity
JOS67_RS17135	COG2866	Carboxypeptidase
JOS67_RS17140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JOS67_RS17150	COG2990	Protein conserved in bacteria
JOS67_RS17175	COG3842	ATPase activity
JOS67_RS17185	COG1840	ABC-type Fe3 transport system, periplasmic component
JOS67_RS17190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JOS67_RS17195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JOS67_RS17200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JOS67_RS17205	COG1609	Transcriptional regulator
JOS67_RS17235	COG3240	lipase activity
JOS67_RS17240	COG2067	long-chain fatty acid transport protein
JOS67_RS17250	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JOS67_RS17265	COG1011	Hydrolase
JOS67_RS17305	COG0110	maltose O-acetyltransferase activity
JOS67_RS17310	COG1765	OsmC-like protein
JOS67_RS17315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JOS67_RS17315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JOS67_RS17330	COG3046	protein related to deoxyribodipyrimidine photolyase
JOS67_RS17335	COG0415	Belongs to the DNA photolyase family
JOS67_RS17340	COG3706	GGDEF domain
JOS67_RS17355	COG3706	GGDEF domain
JOS67_RS17370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JOS67_RS17390	COG3033	Beta-eliminating lyase
JOS67_RS17400	COG1271	oxidase subunit
JOS67_RS17405	COG1294	oxidase, subunit
JOS67_RS17420	COG0579	oxidoreductase
JOS67_RS17435	COG1114	Component of the transport system for branched-chain amino acids
JOS67_RS17440	COG3706	GGDEF domain
JOS67_RS17445	COG2204	response regulator
JOS67_RS17450	COG4191	Histidine kinase
JOS67_RS17460	COG2723	6-phospho-beta-galactosidase activity
JOS67_RS17485	COG0583	DNA-binding transcription factor activity
JOS67_RS17490	COG0189	ligase activity
JOS67_RS17495	COG4067	protein conserved in archaea
JOS67_RS17495	COG0189	ligase activity
JOS67_RS17505	COG1166	arginine decarboxylase activity
JOS67_RS17510	COG0010	Belongs to the arginase family
JOS67_RS17515	COG2814	Major facilitator Superfamily
JOS67_RS17520	COG1770	oligopeptidase
JOS67_RS17535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JOS67_RS17540	COG1121	(ABC) transporter
JOS67_RS17590	COG0848	biopolymer transport protein
JOS67_RS17595	COG0811	peptide transport
JOS67_RS17600	COG0811	peptide transport
JOS67_RS17620	COG0745	RESPONSE REGULATOR receiver
JOS67_RS17625	COG0039	L-malate dehydrogenase activity
JOS67_RS17630	COG0584	glycerophosphoryl diester phosphodiesterase
JOS67_RS17640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JOS67_RS17700	COG1901	pseudouridine methyltransferase
JOS67_RS17705	COG0312	modulator of DNA gyrase
JOS67_RS17710	COG0312	modulator of DNA gyrase
JOS67_RS17715	COG0351	phosphomethylpyrimidine kinase
JOS67_RS17720	COG1116	anion transmembrane transporter activity
JOS67_RS17725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JOS67_RS17730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JOS67_RS17735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JOS67_RS17740	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JOS67_RS17745	COG0352	thiamine-phosphate diphosphorylase activity
JOS67_RS17755	COG0243	molybdopterin cofactor binding
JOS67_RS17760	COG3005	denitrification pathway
JOS67_RS17765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JOS67_RS17770	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS17785	COG0456	acetyltransferase
JOS67_RS17805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JOS67_RS17810	COG1929	Belongs to the glycerate kinase type-1 family
JOS67_RS17815	COG2610	gluconate transmembrane transporter activity
JOS67_RS17820	COG3835	regulator
JOS67_RS17845	COG0546	phosphoglycolate phosphatase activity
JOS67_RS17885	COG3047	cAMP biosynthetic process
JOS67_RS17890	COG1357	PFAM Pentapeptide repeats (8 copies)
JOS67_RS17925	COG2375	cellular response to nickel ion
JOS67_RS17930	COG0583	DNA-binding transcription factor activity
JOS67_RS17935	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JOS67_RS17940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JOS67_RS17955	COG2199	diguanylate cyclase activity
JOS67_RS17965	COG0561	phosphatase activity
JOS67_RS17970	COG0583	DNA-binding transcription factor activity
JOS67_RS17985	COG0564	pseudouridine synthase activity
JOS67_RS17990	COG0534	Mate efflux family protein
JOS67_RS18005	COG3123	guanosine phosphorylase activity
JOS67_RS18020	COG0596	Alpha beta hydrolase
JOS67_RS18045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JOS67_RS18055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JOS67_RS18060	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JOS67_RS18070	COG2259	Doxx family
JOS67_RS18075	COG1741	Belongs to the pirin family
JOS67_RS18095	COG0363	glucosamine-6-phosphate deaminase activity
JOS67_RS18105	COG0786	glutamate:sodium symporter activity
JOS67_RS18110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JOS67_RS18115	COG1131	(ABC) transporter
JOS67_RS18125	COG0786	glutamate:sodium symporter activity
JOS67_RS18145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JOS67_RS18155	COG3279	Response regulator of the LytR AlgR family
JOS67_RS18160	COG3275	phosphorelay sensor kinase activity
JOS67_RS18195	COG0772	Belongs to the SEDS family
JOS67_RS18220	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JOS67_RS18220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JOS67_RS18230	COG0444	Belongs to the ABC transporter superfamily
JOS67_RS18235	COG4608	Belongs to the ABC transporter superfamily
JOS67_RS18260	COG1444	tRNA N-acetyltransferase activity
JOS67_RS18280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JOS67_RS18285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS18285	COG1263	PTS System
JOS67_RS18290	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JOS67_RS18305	COG4166	transmembrane transport
JOS67_RS18350	COG0259	pyridoxamine-phosphate oxidase activity
JOS67_RS18375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JOS67_RS18410	COG1132	(ABC) transporter
JOS67_RS18420	COG2207	Transcriptional regulator
JOS67_RS18445	COG2258	MOSC domain
JOS67_RS18465	COG1595	DNA-templated transcription, initiation
JOS67_RS18490	COG3634	alkyl hydroperoxide reductase activity
JOS67_RS18500	COG1846	Transcriptional regulator
JOS67_RS18505	COG1764	response to oxidative stress
JOS67_RS18520	COG0577	efflux transmembrane transporter activity
JOS67_RS18525	COG1136	(ABC) transporter
JOS67_RS18540	COG0463	Glycosyl transferase, family 2
JOS67_RS18560	COG0826	peptidase U32
JOS67_RS18585	COG1653	transport
JOS67_RS18590	COG0019	diaminopimelate decarboxylase activity
JOS67_RS18595	COG4264	IucA IucC family
JOS67_RS18620	COG4772	TonB-dependent receptor
JOS67_RS18625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JOS67_RS18630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JOS67_RS18635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JOS67_RS18640	COG1120	ATPase activity
JOS67_RS18645	COG0840	transmembrane signaling receptor activity
JOS67_RS18650	COG0612	Peptidase, M16
JOS67_RS18660	COG0739	heme binding
JOS67_RS18720	COG2356	endonuclease I
JOS67_RS18740	COG1982	Orn Lys Arg decarboxylase major
JOS67_RS18745	COG0531	amino acid
JOS67_RS18755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JOS67_RS18760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JOS67_RS18765	COG1162	GTPase activity
JOS67_RS18770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS18770	COG1263	PTS System
JOS67_RS18775	COG1999	signal sequence binding
JOS67_RS18790	COG2909	trisaccharide binding
JOS67_RS18795	COG0058	SHG alpha-glucan phosphorylase activity
JOS67_RS18800	COG1640	4-alpha-glucanotransferase
JOS67_RS18805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JOS67_RS18810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JOS67_RS18815	COG0366	Alpha amylase catalytic
JOS67_RS18830	COG3366	ferrous iron transmembrane transporter activity
JOS67_RS18835	COG0700	Nucleoside recognition
JOS67_RS18845	COG3339	Conserved Protein
JOS67_RS18850	COG1301	dicarboxylic acid transport
JOS67_RS18870	COG1596	polysaccharide export
JOS67_RS18885	COG2095	MarC family integral membrane protein
JOS67_RS18890	COG4667	esterase of the alpha-beta hydrolase superfamily
JOS67_RS18895	COG3397	chitin binding
JOS67_RS18900	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
JOS67_RS18915	COG1054	Belongs to the UPF0176 family
JOS67_RS18925	COG1686	Belongs to the peptidase S11 family
JOS67_RS18950	COG0583	DNA-binding transcription factor activity
JOS67_RS18955	COG4628	conserved protein (DUF2132)
JOS67_RS18970	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JOS67_RS18975	COG0628	permease
JOS67_RS19015	COG2814	Major facilitator Superfamily
JOS67_RS19025	COG0454	-acetyltransferase
JOS67_RS19035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JOS67_RS19040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JOS67_RS19045	COG1882	Formate acetyltransferase
JOS67_RS19090	COG1360	Flagellar Motor Protein
JOS67_RS19095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JOS67_RS19100	COG1191	sigma factor activity
JOS67_RS19105	COG1580	Controls the rotational direction of flagella during chemotaxis
JOS67_RS19120	COG1516	flagellar protein fliS
JOS67_RS19125	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JOS67_RS19135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JOS67_RS19150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JOS67_RS19160	COG1987	bacterial-type flagellum assembly
JOS67_RS19200	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JOS67_RS19255	COG0346	lactoylglutathione lyase activity
JOS67_RS19280	COG0745	RESPONSE REGULATOR receiver
JOS67_RS19300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JOS67_RS19305	COG3300	MHYT domain
JOS67_RS19305	COG5001	Diguanylate cyclase
JOS67_RS19310	COG0156	8-amino-7-oxononanoate synthase activity
JOS67_RS19315	COG1063	alcohol dehydrogenase
JOS67_RS19350	COG0668	transmembrane transport
JOS67_RS19360	COG1304	FMN binding
JOS67_RS19365	COG1620	l-lactate permease
JOS67_RS19370	COG0583	DNA-binding transcription factor activity
JOS67_RS19375	COG1505	serine-type exopeptidase activity
JOS67_RS19380	COG4172	Belongs to the ABC transporter superfamily
JOS67_RS19390	COG1067	ATP-dependent peptidase activity
JOS67_RS19395	COG0840	transmembrane signaling receptor activity
JOS67_RS19400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JOS67_RS19420	COG1247	-acetyltransferase
JOS67_RS19425	COG0437	4 iron, 4 sulfur cluster binding
JOS67_RS19430	COG0348	domain, Protein
JOS67_RS19450	COG1122	ATPase activity
JOS67_RS19455	COG4720	Psort location CytoplasmicMembrane, score
JOS67_RS19460	COG1566	PFAM secretion protein HlyD family protein
JOS67_RS19485	COG0813	purine-nucleoside phosphorylase activity
JOS67_RS19490	COG3272	Protein of unknown function (DUF1722)
JOS67_RS19495	COG0789	Transcriptional regulator
JOS67_RS19500	COG0415	Belongs to the DNA photolyase family
JOS67_RS19505	COG1388	LysM domain
JOS67_RS19505	COG1376	ErfK ybiS ycfS ynhG family protein
JOS67_RS19515	COG0513	Belongs to the DEAD box helicase family
JOS67_RS19520	COG1770	oligopeptidase
JOS67_RS19525	COG4771	TonB-dependent receptor
JOS67_RS19555	COG0573	inorganic phosphate transmembrane transporter activity
JOS67_RS19560	COG0581	inorganic phosphate transmembrane transporter activity
JOS67_RS19565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JOS67_RS19580	COG2304	oxidoreductase activity
JOS67_RS19585	COG2304	oxidoreductase activity
JOS67_RS19600	COG0714	Associated with various cellular activities
JOS67_RS19605	COG0840	transmembrane signaling receptor activity
JOS67_RS19655	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JOS67_RS19660	COG1120	ATPase activity
JOS67_RS19665	COG4774	siderophore transport
JOS67_RS19670	COG1132	(ABC) transporter
JOS67_RS19675	COG2205	protein histidine kinase activity
JOS67_RS19675	COG2205	protein histidine kinase activity
JOS67_RS19685	COG0569	domain protein
JOS67_RS19690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JOS67_RS19695	COG0583	DNA-binding transcription factor activity
JOS67_RS19710	COG1012	belongs to the aldehyde dehydrogenase family
JOS67_RS19715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JOS67_RS19720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JOS67_RS19730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JOS67_RS19735	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
JOS67_RS19740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JOS67_RS19755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS19755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS67_RS19755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS67_RS19760	COG2207	Transcriptional regulator
JOS67_RS19770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS67_RS19775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS67_RS19780	COG2084	Dehydrogenase
JOS67_RS19785	COG0753	catalase activity
JOS67_RS19795	COG2130	NADP-dependent
JOS67_RS19800	COG1309	transcriptional regulator
JOS67_RS19805	COG3097	Belongs to the UPF0267 family
JOS67_RS19860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JOS67_RS19865	COG3842	ATPase activity
JOS67_RS19875	COG1175	transmembrane transport
JOS67_RS19880	COG3833	ABC-type maltose transport systems, permease component
JOS67_RS19910	COG2354	Protein conserved in bacteria
JOS67_RS19915	COG0418	dihydroorotase activity
JOS67_RS19920	COG0401	homolog of Blt101
JOS67_RS19925	COG0633	Ferredoxin
JOS67_RS19925	COG0633	Ferredoxin
JOS67_RS19925	COG3217	Mosc domain protein beta barrel domain protein
JOS67_RS19925	COG3217	Mosc domain protein beta barrel domain protein
JOS67_RS19930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JOS67_RS19935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JOS67_RS19975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JOS67_RS19980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JOS67_RS19990	COG0848	biopolymer transport protein
JOS67_RS19995	COG0811	peptide transport
JOS67_RS20000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JOS67_RS20010	COG3721	Heme iron utilization protein
JOS67_RS20015	COG0748	coenzyme F420 binding
JOS67_RS20025	COG0835	chemotaxis
JOS67_RS20025	COG0784	Response regulator, receiver
JOS67_RS20030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JOS67_RS20065	COG0583	DNA-binding transcription factor activity
JOS67_RS20070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JOS67_RS20080	COG4934	collagen metabolic process
JOS67_RS20095	COG0789	Transcriptional regulator
JOS67_RS20100	COG0366	Alpha amylase catalytic
JOS67_RS20110	COG5433	transposase activity
JOS67_RS20130	COG2249	NAD(P)H dehydrogenase (quinone) activity
JOS67_RS20135	COG0589	response to stress
JOS67_RS20140	COG0488	(ABC) transporter
JOS67_RS20155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS20165	COG2067	long-chain fatty acid transport protein
JOS67_RS20175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JOS67_RS20205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JOS67_RS20240	COG0842	Transport permease protein
JOS67_RS20245	COG1131	(ABC) transporter
JOS67_RS20255	COG2706	6-phosphogluconolactonase activity
JOS67_RS20265	COG1881	PFAM PEBP family protein
JOS67_RS20275	COG0798	PFAM Bile acid sodium symporter
JOS67_RS20290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS20295	COG2213	PTS system mannitol-specific
JOS67_RS20300	COG1063	alcohol dehydrogenase
JOS67_RS20310	COG1072	(Pantothenic acid kinase))
JOS67_RS20315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JOS67_RS20330	COG0814	amino acid
JOS67_RS20340	COG0840	transmembrane signaling receptor activity
JOS67_RS20345	COG3314	Sporulation integral membrane protein YlbJ
JOS67_RS20365	COG0739	heme binding
JOS67_RS20370	COG5001	Diguanylate cyclase
JOS67_RS20375	COG0583	DNA-binding transcription factor activity
JOS67_RS20380	COG2814	Major facilitator Superfamily
JOS67_RS20395	COG0697	spore germination
JOS67_RS20410	COG0179	Fumarylacetoacetate (FAA) hydrolase
JOS67_RS20425	COG2207	Transcriptional regulator
JOS67_RS20430	COG1280	lysine exporter protein (LysE YggA)
JOS67_RS20440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JOS67_RS20445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JOS67_RS20450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JOS67_RS20455	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JOS67_RS20480	COG1612	heme a metabolic process
JOS67_RS20485	COG0109	protoheme IX farnesyltransferase activity
JOS67_RS20490	COG0545	Peptidyl-prolyl cis-trans isomerase
JOS67_RS20520	COG1278	Cold shock
JOS67_RS20525	COG3036	rescue of stalled ribosome
JOS67_RS20530	COG2199	diguanylate cyclase activity
JOS67_RS20550	COG0577	efflux transmembrane transporter activity
JOS67_RS20550	COG1136	(ABC) transporter
JOS67_RS20560	COG0840	transmembrane signaling receptor activity
JOS67_RS20565	COG0783	Belongs to the Dps family
JOS67_RS20575	COG2133	pyrroloquinoline quinone binding
JOS67_RS20580	COG1454	alcohol dehydrogenase
JOS67_RS20585	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JOS67_RS20610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JOS67_RS20615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JOS67_RS20620	COG3186	Phenylalanine-4-hydroxylase
JOS67_RS20645	COG3530	Putative quorum-sensing-regulated virulence factor
JOS67_RS20660	COG1404	Belongs to the peptidase S8 family
JOS67_RS20685	COG0730	response to heat
JOS67_RS20700	COG2814	Major facilitator Superfamily
JOS67_RS20705	COG0513	Belongs to the DEAD box helicase family
JOS67_RS20710	COG4628	conserved protein (DUF2132)
JOS67_RS20720	COG0133	tryptophan synthase activity
JOS67_RS20725	COG0557	exoribonuclease II activity
JOS67_RS20730	COG1278	Cold shock
JOS67_RS20740	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JOS67_RS20750	COG0523	cobalamin synthesis protein
JOS67_RS20755	COG0513	Belongs to the DEAD box helicase family
JOS67_RS20775	COG2200	EAL domain
JOS67_RS20780	COG1119	ATPase activity
JOS67_RS20785	COG0840	transmembrane signaling receptor activity
JOS67_RS20805	COG2890	protein-(glutamine-N5) methyltransferase activity
JOS67_RS20870	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JOS67_RS20875	COG0513	Belongs to the DEAD box helicase family
JOS67_RS20885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JOS67_RS20940	COG0247	lactate metabolic process
JOS67_RS20940	COG0277	FAD linked oxidase domain protein
JOS67_RS20950	COG5413	integral membrane protein
JOS67_RS20960	COG1024	Enoyl-CoA hydratase
JOS67_RS20965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JOS67_RS20970	COG1960	acyl-CoA dehydrogenase activity
JOS67_RS20980	COG0183	Belongs to the thiolase family
JOS67_RS20995	COG1024	Enoyl-CoA hydratase
JOS67_RS21000	COG1024	Enoyl-CoA hydratase
JOS67_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS21015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JOS67_RS21020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JOS67_RS21025	COG1845	cytochrome c oxidase, subunit III
JOS67_RS21030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JOS67_RS21035	COG0109	protoheme IX farnesyltransferase activity
JOS67_RS21045	COG0446	pyridine nucleotide-disulphide oxidoreductase
JOS67_RS21045	COG1902	pentaerythritol trinitrate reductase activity
JOS67_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
JOS67_RS21075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JOS67_RS21105	COG1126	abc transporter atp-binding protein
JOS67_RS21110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JOS67_RS21115	COG4215	(ABC) transporter
JOS67_RS21120	COG4160	amino acid transport
JOS67_RS21185	COG0443	Heat shock 70 kDa protein
JOS67_RS21190	COG2847	Copper chaperone PCu(A)C
JOS67_RS21245	COG0814	amino acid
JOS67_RS21260	COG0243	molybdopterin cofactor binding
JOS67_RS21285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JOS67_RS21285	COG1116	anion transmembrane transporter activity
JOS67_RS21290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JOS67_RS21295	COG1116	anion transmembrane transporter activity
JOS67_RS21300	COG2146	nitrite reductase [NAD(P)H] activity
JOS67_RS21300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JOS67_RS21350	COG2815	serine threonine protein kinase
JOS67_RS21350	COG0515	serine threonine protein kinase
JOS67_RS21385	COG0631	protein serine/threonine phosphatase activity
JOS67_RS21455	COG0420	3'-5' exonuclease activity
JOS67_RS21460	COG0419	ATPase involved in DNA repair
JOS67_RS21470	COG3040	lipid binding
JOS67_RS21480	COG1288	antiporter activity
JOS67_RS21490	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JOS67_RS21505	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JOS67_RS21520	COG0583	DNA-binding transcription factor activity
JOS67_RS21525	COG0277	FAD linked oxidase domain protein
JOS67_RS21540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JOS67_RS21610	COG5001	Diguanylate cyclase
JOS67_RS21615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JOS67_RS21620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JOS67_RS21630	COG2116	formate transmembrane transporter activity
JOS67_RS21650	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JOS67_RS21685	COG3118	belongs to the thioredoxin family
JOS67_RS21690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JOS67_RS21715	COG2271	Major facilitator Superfamily
JOS67_RS21720	COG3851	Histidine kinase
JOS67_RS21725	COG2197	response regulator
JOS67_RS21735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JOS67_RS21740	COG0583	DNA-binding transcription factor activity
JOS67_RS21745	COG0243	molybdopterin cofactor binding
JOS67_RS21755	COG0384	phenazine biosynthesis protein PhzF
JOS67_RS21760	COG1794	racemase activity, acting on amino acids and derivatives
JOS67_RS21795	COG5433	transposase activity
JOS67_RS21815	COG1328	CTP reductase activity
JOS67_RS21820	COG0602	queuosine metabolic process
JOS67_RS21825	COG0534	Mate efflux family protein
JOS67_RS21830	COG2207	Transcriptional regulator
JOS67_RS21840	COG4067	protein conserved in archaea
JOS67_RS21840	COG0189	ligase activity
JOS67_RS21850	COG3111	PFAM Bacterial OB fold (BOF) protein
JOS67_RS21860	COG0725	ABC transporter, periplasmic molybdate-binding protein
JOS67_RS21865	COG4149	molybdate abc transporter
JOS67_RS21870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JOS67_RS21880	COG2203	Gaf domain
JOS67_RS21880	COG3706	GGDEF domain
JOS67_RS21880	COG4251	negative regulation of phosphorylation
JOS67_RS21880	COG5001	Diguanylate cyclase
JOS67_RS21905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JOS67_RS21910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JOS67_RS21935	COG3140	Belongs to the UPF0181 family
JOS67_RS21940	COG0589	response to stress
JOS67_RS21960	COG0023	Translation Initiation Factor
JOS67_RS21970	COG1181	Belongs to the D-alanine--D-alanine ligase family
JOS67_RS21980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JOS67_RS21980	COG1042	CoA-binding domain protein
JOS67_RS21980	COG0045	succinate-CoA ligase (ADP-forming) activity
JOS67_RS21985	COG0583	DNA-binding transcription factor activity
JOS67_RS21995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JOS67_RS22000	COG5002	protein histidine kinase activity
JOS67_RS22000	COG3447	MASE1 domain protein
JOS67_RS22000	COG5001	Diguanylate cyclase
JOS67_RS22005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JOS67_RS22010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JOS67_RS22015	COG1984	allophanate hydrolase subunit 2
JOS67_RS22025	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JOS67_RS22030	COG4181	ATPase activity
JOS67_RS22040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JOS67_RS22045	COG1716	ATPase activity
JOS67_RS22045	COG5001	Diguanylate cyclase
JOS67_RS22080	COG4533	DNA binding
JOS67_RS22090	COG2050	protein possibly involved in aromatic compounds catabolism
JOS67_RS22105	COG2067	long-chain fatty acid transport protein
JOS67_RS22110	COG2267	carboxylic ester hydrolase activity
JOS67_RS22135	COG0737	Belongs to the 5'-nucleotidase family
JOS67_RS22140	COG3593	DNA synthesis involved in DNA repair
JOS67_RS22150	COG0583	DNA-binding transcription factor activity
JOS67_RS22155	COG2116	formate transmembrane transporter activity
JOS67_RS22160	COG2353	YceI-like domain
JOS67_RS22165	COG3038	cytochrome b561
JOS67_RS22180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JOS67_RS22185	COG0513	Belongs to the DEAD box helicase family
JOS67_RS22200	COG0546	phosphoglycolate phosphatase activity
JOS67_RS22215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JOS67_RS22220	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JOS67_RS22225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JOS67_RS22235	COG2207	Transcriptional regulator
JOS67_RS22240	COG1979	alcohol dehydrogenase
JOS67_RS22250	COG1126	abc transporter atp-binding protein
JOS67_RS22255	COG0765	amino acid transport
JOS67_RS22260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JOS67_RS22265	COG0765	amino acid transport
JOS67_RS22270	COG2203	Gaf domain
JOS67_RS22270	COG2199	diguanylate cyclase activity
JOS67_RS22270	COG2200	EAL domain
JOS67_RS22285	COG1609	Transcriptional regulator
JOS67_RS22290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS22290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS67_RS22295	COG1105	Belongs to the carbohydrate kinase PfkB family
JOS67_RS22300	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JOS67_RS22300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS67_RS22300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS67_RS22320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JOS67_RS22330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JOS67_RS22340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JOS67_RS22345	COG0509	glycine decarboxylation via glycine cleavage system
JOS67_RS22350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JOS67_RS22350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JOS67_RS22400	COG0556	nucleotide-excision repair
JOS67_RS22430	COG0346	lactoylglutathione lyase activity
JOS67_RS22435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JOS67_RS22455	COG2176	DNA-directed DNA polymerase activity
JOS67_RS22495	COG0242	peptide deformylase activity
JOS67_RS22525	COG2239	Acts as a magnesium transporter
JOS67_RS22545	COG0346	lactoylglutathione lyase activity
JOS67_RS22550	COG1902	pentaerythritol trinitrate reductase activity
JOS67_RS22570	COG5642	Protein of unknown function (DUF2384)
JOS67_RS22575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JOS67_RS22660	COG0835	chemotaxis
JOS67_RS22660	COG0784	Response regulator, receiver
JOS67_RS22665	COG2197	response regulator
JOS67_RS22675	COG3706	GGDEF domain
JOS67_RS22685	COG5001	Diguanylate cyclase
JOS67_RS22685	COG3300	MHYT domain
JOS67_RS22690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JOS67_RS22710	COG0456	acetyltransferase
JOS67_RS22710	COG1214	PFAM Peptidase M22, glycoprotease
JOS67_RS22720	COG3069	C4-dicarboxylate transmembrane transporter activity
JOS67_RS22725	COG1704	LemA family
JOS67_RS22730	COG0501	Belongs to the peptidase M48B family
JOS67_RS22755	COG3111	PFAM Bacterial OB fold (BOF) protein
JOS67_RS22760	COG1597	lipid kinase activity
JOS67_RS22765	COG0583	DNA-binding transcription factor activity
JOS67_RS22770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JOS67_RS22770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JOS67_RS22800	COG0714	Associated with various cellular activities
JOS67_RS22805	COG0641	radical SAM
JOS67_RS22810	COG3119	arylsulfatase activity
JOS67_RS22820	COG3119	arylsulfatase activity
JOS67_RS22840	COG0784	Response regulator, receiver
JOS67_RS22840	COG2198	Histidine kinase
JOS67_RS22840	COG2205	protein histidine kinase activity
JOS67_RS22845	COG1879	ABC-type sugar transport system periplasmic component
JOS67_RS22850	COG1803	Methylglyoxal synthase
JOS67_RS22855	COG0210	DNA helicase
JOS67_RS22860	COG1289	transmembrane transporter activity
JOS67_RS22890	COG4771	TonB-dependent receptor
JOS67_RS22890	COG1629	transport
JOS67_RS22895	COG2207	Transcriptional regulator
JOS67_RS22900	COG0789	Transcriptional regulator
JOS67_RS22905	COG4604	ABC transporter, ATP-binding protein
JOS67_RS22910	COG4605	iron ion homeostasis
JOS67_RS22915	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JOS67_RS22920	COG4607	ABC-type enterochelin transport system periplasmic component
JOS67_RS22930	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JOS67_RS22940	COG1609	Transcriptional regulator
JOS67_RS22945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JOS67_RS22950	COG1879	ABC-type sugar transport system periplasmic component
JOS67_RS22955	COG1172	Belongs to the binding-protein-dependent transport system permease family
JOS67_RS22960	COG1129	ABC transporter
JOS67_RS22965	COG1869	D-ribose catabolic process
JOS67_RS22970	COG5001	Diguanylate cyclase
JOS67_RS23015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JOS67_RS23025	COG0784	Response regulator, receiver
JOS67_RS23025	COG2205	protein histidine kinase activity
JOS67_RS23035	COG3300	MHYT domain
JOS67_RS23035	COG5001	Diguanylate cyclase
JOS67_RS23045	COG0330	HflC and HflK could
JOS67_RS23060	COG4175	Glycine betaine
JOS67_RS23060	COG0517	IMP dehydrogenase activity
JOS67_RS23065	COG4176	ABC-type proline glycine betaine transport system permease component
JOS67_RS23080	COG1012	belongs to the aldehyde dehydrogenase family
JOS67_RS23085	COG1309	transcriptional regulator
JOS67_RS23095	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS23110	COG1024	Enoyl-CoA hydratase
JOS67_RS23115	COG1960	acyl-CoA dehydrogenase activity
JOS67_RS23125	COG0183	Belongs to the thiolase family
JOS67_RS23135	COG1960	acyl-CoA dehydrogenase activity
JOS67_RS23140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JOS67_RS23145	COG1024	Enoyl-CoA hydratase
JOS67_RS23150	COG4770	biotin carboxylase activity
JOS67_RS23160	COG3850	Histidine kinase
JOS67_RS23160	COG3437	response regulator, receiver
JOS67_RS23160	COG4999	Histidine kinase
JOS67_RS23160	COG2205	protein histidine kinase activity
JOS67_RS23180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JOS67_RS23185	COG1271	oxidase subunit
JOS67_RS23190	COG1294	oxidase, subunit
JOS67_RS23200	COG0384	phenazine biosynthesis protein PhzF
JOS67_RS23205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JOS67_RS23215	COG3527	Alpha-acetolactate decarboxylase
JOS67_RS23225	COG1028	Short-chain dehydrogenase reductase Sdr
JOS67_RS23230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JOS67_RS23290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JOS67_RS23295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS67_RS23295	COG1263	PTS System
JOS67_RS23300	COG1486	melibiose metabolic process
JOS67_RS23305	COG2188	Transcriptional regulator
JOS67_RS23310	COG1320	monovalent cation:proton antiporter activity
JOS67_RS23315	COG2212	antiporter activity
JOS67_RS23320	COG1863	multisubunit Na H antiporter MnhE subunit
JOS67_RS23325	COG0651	ATP synthesis coupled electron transport
JOS67_RS23330	COG1006	Multisubunit Na H antiporter MnhC subunit
JOS67_RS23335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JOS67_RS23335	COG2111	Na H antiporter
JOS67_RS23345	COG0589	response to stress
JOS67_RS23350	COG4221	oxidoreductase activity
JOS67_RS23355	COG0583	DNA-binding transcription factor activity
JOS67_RS23365	COG2814	Major facilitator Superfamily
JOS67_RS23450	COG1522	sequence-specific DNA binding
JOS67_RS23485	COG0515	serine threonine protein kinase
JOS67_RS23510	COG3501	Rhs element vgr protein
JOS67_RS23575	COG0739	heme binding
JOS67_RS23585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JOS67_RS23585	COG0674	pyruvate-flavodoxin oxidoreductase activity
JOS67_RS23590	COG1013	pyruvate-flavodoxin oxidoreductase activity
JOS67_RS23605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JOS67_RS23605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JOS67_RS23620	COG4989	oxidoreductase activity
JOS67_RS23635	COG0038	chloride channel
JOS67_RS23645	COG1914	H( )-stimulated, divalent metal cation uptake system
JOS67_RS23660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JOS67_RS23680	COG2897	thiosulfate sulfurtransferase activity
JOS67_RS23700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JOS67_RS23705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JOS67_RS23710	COG0840	transmembrane signaling receptor activity
JOS67_RS23715	COG2814	Major facilitator Superfamily
JOS67_RS23720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JOS67_RS23730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JOS67_RS23740	COG0840	transmembrane signaling receptor activity
JOS67_RS23760	COG2195	Cleaves the N-terminal amino acid of tripeptides
JOS67_RS23775	COG2197	response regulator
JOS67_RS23780	COG3850	Histidine kinase
JOS67_RS23785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JOS67_RS23795	COG0243	molybdopterin cofactor binding
JOS67_RS23805	COG3005	denitrification pathway
JOS67_RS23815	COG3243	poly(R)-hydroxyalkanoic acid synthase
JOS67_RS23825	COG0183	Belongs to the thiolase family
JOS67_RS23835	COG1280	lysine exporter protein (LysE YggA)
JOS67_RS23845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JOS67_RS23850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JOS67_RS23905	COG2205	protein histidine kinase activity
JOS67_RS23905	COG0784	Response regulator, receiver
JOS67_RS23910	COG1879	ABC-type sugar transport system periplasmic component
JOS67_RS23915	COG2827	Endonuclease containing a URI domain
JOS67_RS23920	COG3132	Protein of unknown function, DUF480
JOS67_RS23935	COG0534	Mate efflux family protein
JOS67_RS23940	COG2205	protein histidine kinase activity
JOS67_RS23940	COG5002	protein histidine kinase activity
JOS67_RS23940	COG0784	Response regulator, receiver
JOS67_RS23960	COG0583	DNA-binding transcription factor activity
JOS67_RS23970	COG0531	amino acid
JOS67_RS23985	COG2205	protein histidine kinase activity
JOS67_RS23990	COG0745	RESPONSE REGULATOR receiver
JOS67_RS24015	COG1566	PFAM secretion protein HlyD family protein
JOS67_RS24020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JOS67_RS24025	COG2239	Acts as a magnesium transporter