locus-tag	class	description
IXK98_RS00120	COG3140	Belongs to the UPF0181 family
IXK98_RS00135	COG0745	RESPONSE REGULATOR receiver
IXK98_RS00145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IXK98_RS00150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IXK98_RS00165	COG3706	GGDEF domain
IXK98_RS00170	COG5001	Diguanylate cyclase
IXK98_RS00170	COG4251	negative regulation of phosphorylation
IXK98_RS00170	COG3706	GGDEF domain
IXK98_RS00170	COG2203	Gaf domain
IXK98_RS00180	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IXK98_RS00185	COG4149	molybdate abc transporter
IXK98_RS00190	COG0725	ABC transporter, periplasmic molybdate-binding protein
IXK98_RS00195	COG1492	cobalamin metabolic process
IXK98_RS00200	COG3111	PFAM Bacterial OB fold (BOF) protein
IXK98_RS00210	COG1609	Transcriptional regulator
IXK98_RS00215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS00215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS00220	COG1105	Belongs to the carbohydrate kinase PfkB family
IXK98_RS00225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS00225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS00225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IXK98_RS00235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IXK98_RS00245	COG2207	Transcriptional regulator
IXK98_RS00250	COG1979	alcohol dehydrogenase
IXK98_RS00265	COG2205	protein histidine kinase activity
IXK98_RS00265	COG0784	Response regulator, receiver
IXK98_RS00265	COG2198	Histidine kinase
IXK98_RS00270	COG1879	ABC-type sugar transport system periplasmic component
IXK98_RS00275	COG1803	Methylglyoxal synthase
IXK98_RS00285	COG0546	phosphoglycolate phosphatase activity
IXK98_RS00300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXK98_RS00305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXK98_RS00330	COG0456	acetyltransferase
IXK98_RS00330	COG1214	PFAM Peptidase M22, glycoprotease
IXK98_RS00350	COG0513	Belongs to the DEAD box helicase family
IXK98_RS00360	COG0814	amino acid
IXK98_RS00365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXK98_RS00365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXK98_RS00380	COG0513	Belongs to the DEAD box helicase family
IXK98_RS00390	COG0303	'Molybdopterin
IXK98_RS00395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXK98_RS00410	COG2897	thiosulfate sulfurtransferase activity
IXK98_RS00465	COG4964	Belongs to the GSP D family
IXK98_RS00485	COG0583	DNA-binding transcription factor activity
IXK98_RS00500	COG0583	DNA-binding transcription factor activity
IXK98_RS00515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXK98_RS00520	COG1522	sequence-specific DNA binding
IXK98_RS00525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IXK98_RS00535	COG0840	transmembrane signaling receptor activity
IXK98_RS00545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXK98_RS00550	COG1067	ATP-dependent peptidase activity
IXK98_RS00560	COG4172	Belongs to the ABC transporter superfamily
IXK98_RS00570	COG0583	DNA-binding transcription factor activity
IXK98_RS00575	COG1620	l-lactate permease
IXK98_RS00580	COG1304	FMN binding
IXK98_RS00635	COG0463	Glycosyl transferase, family 2
IXK98_RS00660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IXK98_RS00680	COG3284	Transcriptional regulator
IXK98_RS00685	COG1012	belongs to the aldehyde dehydrogenase family
IXK98_RS00725	COG2205	protein histidine kinase activity
IXK98_RS00730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS00730	COG1263	PTS System
IXK98_RS00735	COG4175	Glycine betaine
IXK98_RS00755	COG1012	belongs to the aldehyde dehydrogenase family
IXK98_RS00765	COG5002	protein histidine kinase activity
IXK98_RS00765	COG0784	Response regulator, receiver
IXK98_RS00765	COG2205	protein histidine kinase activity
IXK98_RS00770	COG0745	RESPONSE REGULATOR receiver
IXK98_RS00790	COG4774	siderophore transport
IXK98_RS00805	COG3251	PFAM MbtH domain protein
IXK98_RS00810	COG4615	Cyclic peptide transporter
IXK98_RS00820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IXK98_RS00825	COG1120	ATPase activity
IXK98_RS00865	COG1121	(ABC) transporter
IXK98_RS00870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IXK98_RS00910	COG0516	GMP reductase activity
IXK98_RS00920	COG0516	GMP reductase activity
IXK98_RS00930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IXK98_RS00945	COG2375	cellular response to nickel ion
IXK98_RS00950	COG0583	DNA-binding transcription factor activity
IXK98_RS00960	COG0564	pseudouridine synthase activity
IXK98_RS00985	COG0513	Belongs to the DEAD box helicase family
IXK98_RS00990	COG3097	Belongs to the UPF0267 family
IXK98_RS01000	COG1309	transcriptional regulator
IXK98_RS01005	COG2130	NADP-dependent
IXK98_RS01020	COG2084	Dehydrogenase
IXK98_RS01035	COG0366	Alpha amylase catalytic
IXK98_RS01040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXK98_RS01045	COG0625	glutathione transferase activity
IXK98_RS01085	COG0745	RESPONSE REGULATOR receiver
IXK98_RS01105	COG1309	transcriptional regulator
IXK98_RS01140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IXK98_RS01145	COG3300	MHYT domain
IXK98_RS01145	COG5001	Diguanylate cyclase
IXK98_RS01170	COG1271	oxidase subunit
IXK98_RS01175	COG1294	oxidase, subunit
IXK98_RS01220	COG4969	Belongs to the N-Me-Phe pilin family
IXK98_RS01225	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IXK98_RS01240	COG1357	PFAM Pentapeptide repeats (8 copies)
IXK98_RS01255	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IXK98_RS01295	COG0443	Heat shock 70 kDa protein
IXK98_RS01300	COG0583	DNA-binding transcription factor activity
IXK98_RS01310	COG4948	Mandelate Racemase Muconate Lactonizing
IXK98_RS01330	COG0366	Alpha amylase catalytic
IXK98_RS01335	COG2182	Extracellular solute-binding protein
IXK98_RS01345	COG0366	Alpha amylase catalytic
IXK98_RS01360	COG3275	phosphorelay sensor kinase activity
IXK98_RS01375	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXK98_RS01380	COG1136	(ABC) transporter
IXK98_RS01400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXK98_RS01405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXK98_RS01445	COG2154	pterin-4-alpha-carbinolamine dehydratase
IXK98_RS01450	COG3186	Phenylalanine-4-hydroxylase
IXK98_RS01455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IXK98_RS01475	COG0384	phenazine biosynthesis protein PhzF
IXK98_RS01495	COG2226	methyltransferase
IXK98_RS01515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IXK98_RS01520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IXK98_RS01530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IXK98_RS01535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IXK98_RS01535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IXK98_RS01545	COG0745	RESPONSE REGULATOR receiver
IXK98_RS01550	COG3437	response regulator, receiver
IXK98_RS01555	COG2205	protein histidine kinase activity
IXK98_RS01555	COG4999	Histidine kinase
IXK98_RS01555	COG3437	response regulator, receiver
IXK98_RS01555	COG3850	Histidine kinase
IXK98_RS01565	COG2172	sigma factor antagonist activity
IXK98_RS01575	COG1366	Belongs to the anti-sigma-factor antagonist family
IXK98_RS01580	COG0840	transmembrane signaling receptor activity
IXK98_RS01620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXK98_RS01630	COG2096	Adenosyltransferase
IXK98_RS01635	COG0748	coenzyme F420 binding
IXK98_RS01640	COG3721	Heme iron utilization protein
IXK98_RS01645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXK98_RS01650	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IXK98_RS01655	COG0811	peptide transport
IXK98_RS01660	COG0848	biopolymer transport protein
IXK98_RS01670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IXK98_RS01675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IXK98_RS01685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IXK98_RS01695	COG3047	cAMP biosynthetic process
IXK98_RS01700	COG0739	heme binding
IXK98_RS01725	COG3314	Sporulation integral membrane protein YlbJ
IXK98_RS01735	COG2203	Gaf domain
IXK98_RS01735	COG2199	diguanylate cyclase activity
IXK98_RS01770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IXK98_RS01775	COG0581	inorganic phosphate transmembrane transporter activity
IXK98_RS01780	COG0573	inorganic phosphate transmembrane transporter activity
IXK98_RS01790	COG0840	transmembrane signaling receptor activity
IXK98_RS01805	COG0835	chemotaxis
IXK98_RS01805	COG0784	Response regulator, receiver
IXK98_RS01815	COG4191	Histidine kinase
IXK98_RS01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS01820	COG3437	response regulator, receiver
IXK98_RS01820	COG0784	Response regulator, receiver
IXK98_RS01825	COG1609	Transcriptional regulator
IXK98_RS01830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXK98_RS01835	COG1879	ABC-type sugar transport system periplasmic component
IXK98_RS01840	COG1172	Belongs to the binding-protein-dependent transport system permease family
IXK98_RS01845	COG1129	ABC transporter
IXK98_RS01850	COG1869	D-ribose catabolic process
IXK98_RS01860	COG0004	ammonium transporteR
IXK98_RS01880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IXK98_RS01890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXK98_RS01895	COG0509	glycine decarboxylation via glycine cleavage system
IXK98_RS01910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IXK98_RS01930	COG4191	Histidine kinase
IXK98_RS01930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS01955	COG1396	sequence-specific DNA binding
IXK98_RS01965	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS01980	COG3501	Rhs element vgr protein
IXK98_RS02000	COG3501	Rhs element vgr protein
IXK98_RS02000	COG3409	Peptidoglycan-binding domain 1 protein
IXK98_RS02040	COG1609	Transcriptional regulator
IXK98_RS02045	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IXK98_RS02050	COG3265	gluconokinase activity
IXK98_RS02055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IXK98_RS02060	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IXK98_RS02105	COG1032	radical SAM domain protein
IXK98_RS02115	COG3123	guanosine phosphorylase activity
IXK98_RS02125	COG0668	transmembrane transport
IXK98_RS02130	COG2211	Major facilitator Superfamily
IXK98_RS02145	COG0366	Alpha amylase catalytic
IXK98_RS02205	COG4191	Histidine kinase
IXK98_RS02205	COG0784	Response regulator, receiver
IXK98_RS02215	COG0561	phosphatase activity
IXK98_RS02220	COG0346	lactoylglutathione lyase activity
IXK98_RS02235	COG0456	acetyltransferase
IXK98_RS02280	COG0697	spore germination
IXK98_RS02315	COG3706	GGDEF domain
IXK98_RS02320	COG0488	(ABC) transporter
IXK98_RS02325	COG0348	domain, Protein
IXK98_RS02330	COG0437	4 iron, 4 sulfur cluster binding
IXK98_RS02335	COG3383	formate dehydrogenase (NAD+) activity
IXK98_RS02375	COG1683	Conserved Protein
IXK98_RS02400	COG0183	Belongs to the thiolase family
IXK98_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS02430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IXK98_RS02455	COG0346	lactoylglutathione lyase activity
IXK98_RS02480	COG3300	MHYT domain
IXK98_RS02480	COG5001	Diguanylate cyclase
IXK98_RS02495	COG2814	Major facilitator Superfamily
IXK98_RS02505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXK98_RS02510	COG2423	ornithine cyclodeaminase activity
IXK98_RS02515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXK98_RS02515	COG2022	thiamine diphosphate biosynthetic process
IXK98_RS02520	COG3938	Belongs to the proline racemase family
IXK98_RS02550	COG1653	transport
IXK98_RS02560	COG5001	Diguanylate cyclase
IXK98_RS02560	COG5002	protein histidine kinase activity
IXK98_RS02590	COG0601	transmembrane transport
IXK98_RS02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IXK98_RS02615	COG4628	conserved protein (DUF2132)
IXK98_RS02620	COG0024	Methionine aminopeptidase
IXK98_RS02650	COG2186	Transcriptional regulator
IXK98_RS02660	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IXK98_RS02670	COG0246	Mannitol dehydrogenase
IXK98_RS02680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXK98_RS02685	COG0800	Aldolase
IXK98_RS02740	COG3568	Endonuclease Exonuclease Phosphatase
IXK98_RS02745	COG3291	Pkd domain containing protein
IXK98_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS02785	COG1671	Belongs to the UPF0178 family
IXK98_RS02790	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS02795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXK98_RS02800	COG1301	dicarboxylic acid transport
IXK98_RS02805	COG2200	EAL domain
IXK98_RS02805	COG2199	diguanylate cyclase activity
IXK98_RS02840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXK98_RS02845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IXK98_RS02870	COG2986	histidine ammonia-lyase
IXK98_RS02895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXK98_RS02900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXK98_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS02915	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IXK98_RS02925	COG1278	Cold shock
IXK98_RS02930	COG3122	Protein conserved in bacteria
IXK98_RS02935	COG1166	arginine decarboxylase activity
IXK98_RS02940	COG0010	Belongs to the arginase family
IXK98_RS02975	COG2186	Transcriptional regulator
IXK98_RS02985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IXK98_RS02995	COG0402	S-adenosylhomocysteine deaminase activity
IXK98_RS03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS03005	COG0840	transmembrane signaling receptor activity
IXK98_RS03025	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IXK98_RS03040	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IXK98_RS03045	COG0804	urea catabolic process
IXK98_RS03050	COG0832	Belongs to the urease beta subunit family
IXK98_RS03055	COG0831	urea catabolic process
IXK98_RS03080	COG0559	Belongs to the binding-protein-dependent transport system permease family
IXK98_RS03090	COG1404	Belongs to the peptidase S8 family
IXK98_RS03100	COG0840	transmembrane signaling receptor activity
IXK98_RS03110	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IXK98_RS03115	COG4266	Belongs to the allantoicase family
IXK98_RS03135	COG2252	PERMEase
IXK98_RS03200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS03205	COG1609	Transcriptional regulator
IXK98_RS03215	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS03230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IXK98_RS03240	COG1012	belongs to the aldehyde dehydrogenase family
IXK98_RS03255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXK98_RS03260	COG1482	cell wall glycoprotein biosynthetic process
IXK98_RS03265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS03265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS03265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS03275	COG0383	alpha-mannosidase activity
IXK98_RS03280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS03280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS03280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS03300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXK98_RS03305	COG3394	polysaccharide catabolic process
IXK98_RS03315	COG0488	(ABC) transporter
IXK98_RS03335	COG3655	Transcriptional regulator
IXK98_RS03350	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IXK98_RS03355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IXK98_RS03365	COG1733	regulation of RNA biosynthetic process
IXK98_RS03380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXK98_RS03395	COG1418	mRNA catabolic process
IXK98_RS03410	COG2814	Major facilitator Superfamily
IXK98_RS03430	COG3639	organic phosphonate transmembrane transporter activity
IXK98_RS03435	COG3639	organic phosphonate transmembrane transporter activity
IXK98_RS03440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IXK98_RS03490	COG0242	peptide deformylase activity
IXK98_RS03500	COG0596	Alpha beta hydrolase
IXK98_RS03505	COG0583	DNA-binding transcription factor activity
IXK98_RS03510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IXK98_RS03515	COG0569	domain protein
IXK98_RS03525	COG2205	protein histidine kinase activity
IXK98_RS03545	COG2706	6-phosphogluconolactonase activity
IXK98_RS03555	COG0800	Aldolase
IXK98_RS03565	COG4145	pantothenate transmembrane transporter activity
IXK98_RS03575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IXK98_RS03595	COG1131	(ABC) transporter
IXK98_RS03600	COG2188	Transcriptional regulator
IXK98_RS03620	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS03625	COG3716	PTS system mannose fructose sorbose family IID component
IXK98_RS03635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS03640	COG2222	sugar isomerase
IXK98_RS03650	COG1349	DNA-binding transcription factor activity
IXK98_RS03655	COG1349	DNA-binding transcription factor activity
IXK98_RS03670	COG1136	(ABC) transporter
IXK98_RS03675	COG0577	efflux transmembrane transporter activity
IXK98_RS03705	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXK98_RS03720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXK98_RS03725	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IXK98_RS03730	COG0527	aspartate kinase activity
IXK98_RS03735	COG0662	Cupin 2, conserved barrel domain protein
IXK98_RS03740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IXK98_RS03745	COG0456	acetyltransferase
IXK98_RS03755	COG4977	sequence-specific DNA binding
IXK98_RS03755	COG1917	Cupin 2, conserved barrel domain protein
IXK98_RS03760	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS03765	COG1522	sequence-specific DNA binding
IXK98_RS03775	COG2258	MOSC domain
IXK98_RS03780	COG1609	Transcriptional regulator
IXK98_RS03785	COG1757	Na H antiporter
IXK98_RS03790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IXK98_RS03825	COG3706	GGDEF domain
IXK98_RS03830	COG0204	Acyl-transferase
IXK98_RS03870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXK98_RS03890	COG1175	transmembrane transport
IXK98_RS03895	COG0583	DNA-binding transcription factor activity
IXK98_RS03910	COG2814	Major facilitator Superfamily
IXK98_RS03915	COG3214	Protein conserved in bacteria
IXK98_RS03920	COG3321	synthase
IXK98_RS03920	COG0604	alcohol dehydrogenase
IXK98_RS03920	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS03930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXK98_RS03930	COG0646	methionine synthase
IXK98_RS03935	COG2176	DNA-directed DNA polymerase activity
IXK98_RS03975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXK98_RS03980	COG0840	transmembrane signaling receptor activity
IXK98_RS03985	COG0835	chemotaxis
IXK98_RS04000	COG0745	RESPONSE REGULATOR receiver
IXK98_RS04010	COG1444	tRNA N-acetyltransferase activity
IXK98_RS04040	COG4608	Belongs to the ABC transporter superfamily
IXK98_RS04045	COG0444	Belongs to the ABC transporter superfamily
IXK98_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS04090	COG1733	regulation of RNA biosynthetic process
IXK98_RS04115	COG0110	maltose O-acetyltransferase activity
IXK98_RS04130	COG1342	Belongs to the UPF0251 family
IXK98_RS04145	COG0583	DNA-binding transcription factor activity
IXK98_RS04165	COG0697	spore germination
IXK98_RS04195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXK98_RS04200	COG2135	peptidase activity
IXK98_RS04210	COG1846	Transcriptional regulator
IXK98_RS04220	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IXK98_RS04225	COG3960	tartronate-semialdehyde synthase activity
IXK98_RS04230	COG3622	Belongs to the hyi family
IXK98_RS04235	COG2084	Dehydrogenase
IXK98_RS04240	COG3835	regulator
IXK98_RS04245	COG2610	gluconate transmembrane transporter activity
IXK98_RS04250	COG1929	Belongs to the glycerate kinase type-1 family
IXK98_RS04255	COG1901	pseudouridine methyltransferase
IXK98_RS04290	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IXK98_RS04310	COG0589	response to stress
IXK98_RS04345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IXK98_RS04345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IXK98_RS04350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IXK98_RS04365	COG0768	penicillin binding
IXK98_RS04385	COG0583	DNA-binding transcription factor activity
IXK98_RS04395	COG0351	phosphomethylpyrimidine kinase
IXK98_RS04400	COG1116	anion transmembrane transporter activity
IXK98_RS04405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IXK98_RS04410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IXK98_RS04415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IXK98_RS04420	COG2203	Gaf domain
IXK98_RS04420	COG2199	diguanylate cyclase activity
IXK98_RS04425	COG0671	phosphoesterase, PA-phosphatase related
IXK98_RS04450	COG0583	DNA-binding transcription factor activity
IXK98_RS04480	COG0739	heme binding
IXK98_RS04490	COG1063	alcohol dehydrogenase
IXK98_RS04510	COG1595	DNA-templated transcription, initiation
IXK98_RS04550	COG4964	Belongs to the GSP D family
IXK98_RS04560	COG0455	bacterial-type flagellum organization
IXK98_RS04585	COG2885	chlorophyll binding
IXK98_RS04590	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IXK98_RS04610	COG0596	Alpha beta hydrolase
IXK98_RS04620	COG4221	oxidoreductase activity
IXK98_RS04625	COG0471	metal ion transport
IXK98_RS04630	COG2988	succinylglutamate desuccinylase activity
IXK98_RS04635	COG0523	cobalamin synthesis protein
IXK98_RS04640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IXK98_RS04650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXK98_RS04670	COG2814	Major facilitator Superfamily
IXK98_RS04675	COG1902	pentaerythritol trinitrate reductase activity
IXK98_RS04680	COG1012	belongs to the aldehyde dehydrogenase family
IXK98_RS04715	COG0561	phosphatase activity
IXK98_RS04725	COG1454	alcohol dehydrogenase
IXK98_RS04730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXK98_RS04740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXK98_RS04750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXK98_RS04755	COG1263	PTS System
IXK98_RS04755	COG2190	(PTS) system
IXK98_RS04755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS04765	COG0814	amino acid
IXK98_RS04770	COG2909	trisaccharide binding
IXK98_RS04775	COG0058	SHG alpha-glucan phosphorylase activity
IXK98_RS04780	COG1640	4-alpha-glucanotransferase
IXK98_RS04785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IXK98_RS04815	COG3710	Transcriptional regulator
IXK98_RS04865	COG1741	Belongs to the pirin family
IXK98_RS04885	COG1132	(ABC) transporter
IXK98_RS04900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IXK98_RS04920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IXK98_RS04925	COG1120	ATPase activity
IXK98_RS04930	COG2814	Major facilitator Superfamily
IXK98_RS04945	COG0786	glutamate:sodium symporter activity
IXK98_RS04965	COG1247	-acetyltransferase
IXK98_RS04985	COG0137	argininosuccinate synthase activity
IXK98_RS05025	COG2814	Major facilitator Superfamily
IXK98_RS05035	COG0642	Histidine kinase
IXK98_RS05040	COG0745	RESPONSE REGULATOR receiver
IXK98_RS05065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXK98_RS05080	COG0583	DNA-binding transcription factor activity
IXK98_RS05085	COG3314	Sporulation integral membrane protein YlbJ
IXK98_RS05110	COG4533	DNA binding
IXK98_RS05115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXK98_RS05125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IXK98_RS05130	COG1151	hydroxylamine reductase activity
IXK98_RS05140	COG0671	phosphoesterase, PA-phosphatase related
IXK98_RS05155	COG1494	fructose-1,6-bisphosphatase
IXK98_RS05160	COG0698	ribose 5-phosphate isomerase
IXK98_RS05165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IXK98_RS05175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IXK98_RS05175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IXK98_RS05185	COG2376	Dihydroxyacetone kinase
IXK98_RS05190	COG1461	Dihydroxyacetone kinase
IXK98_RS05200	COG0679	Auxin Efflux Carrier
IXK98_RS05215	COG3604	Transcriptional regulator
IXK98_RS05235	COG2814	Major facilitator Superfamily
IXK98_RS05245	COG2329	Antibiotic biosynthesis monooxygenase
IXK98_RS05260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS05270	COG0583	DNA-binding transcription factor activity
IXK98_RS05285	COG2814	Major facilitator Superfamily
IXK98_RS05290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXK98_RS05295	COG1940	carbohydrate kinase activity
IXK98_RS05300	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IXK98_RS05305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IXK98_RS05310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IXK98_RS05315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IXK98_RS05320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXK98_RS05325	COG1737	Transcriptional regulator
IXK98_RS05330	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IXK98_RS05335	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IXK98_RS05340	COG4409	exo-alpha-(2->6)-sialidase activity
IXK98_RS05355	COG4580	involved in the transport of maltose and maltodextrins
IXK98_RS05375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IXK98_RS05390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IXK98_RS05400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IXK98_RS05405	COG3366	ferrous iron transmembrane transporter activity
IXK98_RS05410	COG0700	Nucleoside recognition
IXK98_RS05415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXK98_RS05420	COG0583	DNA-binding transcription factor activity
IXK98_RS05435	COG4774	siderophore transport
IXK98_RS05465	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS05480	COG4232	protein-disulfide reductase activity
IXK98_RS05485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXK98_RS05495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXK98_RS05500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXK98_RS05505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXK98_RS05510	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IXK98_RS05515	COG1845	cytochrome c oxidase, subunit III
IXK98_RS05535	COG1612	heme a metabolic process
IXK98_RS05540	COG0109	protoheme IX farnesyltransferase activity
IXK98_RS05555	COG0765	amino acid transport
IXK98_RS05560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS05565	COG0765	amino acid transport
IXK98_RS05570	COG1126	abc transporter atp-binding protein
IXK98_RS05575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXK98_RS05585	COG4175	Glycine betaine
IXK98_RS05585	COG3448	diguanylate cyclase activity
IXK98_RS05590	COG4176	ABC-type proline glycine betaine transport system permease component
IXK98_RS05625	COG4964	Belongs to the GSP D family
IXK98_RS05635	COG2894	cell division
IXK98_RS05690	COG1477	protein flavinylation
IXK98_RS05710	COG4221	oxidoreductase activity
IXK98_RS05725	COG0363	glucosamine-6-phosphate deaminase activity
IXK98_RS05735	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IXK98_RS05740	COG1162	GTPase activity
IXK98_RS05750	COG1999	signal sequence binding
IXK98_RS05760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXK98_RS05765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IXK98_RS05770	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IXK98_RS05775	COG3033	Beta-eliminating lyase
IXK98_RS05805	COG0259	pyridoxamine-phosphate oxidase activity
IXK98_RS05815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IXK98_RS05840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXK98_RS05870	COG0840	transmembrane signaling receptor activity
IXK98_RS05875	COG0454	-acetyltransferase
IXK98_RS05905	COG4720	Psort location CytoplasmicMembrane, score
IXK98_RS05910	COG1566	PFAM secretion protein HlyD family protein
IXK98_RS05935	COG0813	purine-nucleoside phosphorylase activity
IXK98_RS05940	COG3272	Protein of unknown function (DUF1722)
IXK98_RS05945	COG0789	Transcriptional regulator
IXK98_RS05950	COG0415	Belongs to the DNA photolyase family
IXK98_RS05955	COG1376	ErfK ybiS ycfS ynhG family protein
IXK98_RS05955	COG1388	LysM domain
IXK98_RS05965	COG0513	Belongs to the DEAD box helicase family
IXK98_RS05975	COG0513	Belongs to the DEAD box helicase family
IXK98_RS05980	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IXK98_RS05995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IXK98_RS06005	COG0330	HflC and HflK could
IXK98_RS06015	COG2211	Major facilitator Superfamily
IXK98_RS06020	COG1486	melibiose metabolic process
IXK98_RS06025	COG2169	Transcriptional regulator
IXK98_RS06030	COG3842	ATPase activity
IXK98_RS06040	COG1175	transmembrane transport
IXK98_RS06045	COG3833	ABC-type maltose transport systems, permease component
IXK98_RS06095	COG0402	S-adenosylhomocysteine deaminase activity
IXK98_RS06100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IXK98_RS06105	COG2239	Acts as a magnesium transporter
IXK98_RS06110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXK98_RS06135	COG0121	glutamine amidotransferase
IXK98_RS06145	COG0531	amino acid
IXK98_RS06165	COG0673	inositol 2-dehydrogenase activity
IXK98_RS06170	COG1765	OsmC-like protein
IXK98_RS06200	COG2304	oxidoreductase activity
IXK98_RS06205	COG2304	oxidoreductase activity
IXK98_RS06220	COG0714	Associated with various cellular activities
IXK98_RS06240	COG0583	DNA-binding transcription factor activity
IXK98_RS06265	COG3706	GGDEF domain
IXK98_RS06270	COG0418	dihydroorotase activity
IXK98_RS06275	COG0401	homolog of Blt101
IXK98_RS06280	COG0633	Ferredoxin
IXK98_RS06280	COG3217	Mosc domain protein beta barrel domain protein
IXK98_RS06280	COG0633	Ferredoxin
IXK98_RS06280	COG3217	Mosc domain protein beta barrel domain protein
IXK98_RS06285	COG2199	diguanylate cyclase activity
IXK98_RS06300	COG0747	negative chemotaxis
IXK98_RS06305	COG0601	transmembrane transport
IXK98_RS06315	COG4172	Belongs to the ABC transporter superfamily
IXK98_RS06330	COG0366	Alpha amylase catalytic
IXK98_RS06355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IXK98_RS06365	COG3300	MHYT domain
IXK98_RS06365	COG5001	Diguanylate cyclase
IXK98_RS06370	COG0583	DNA-binding transcription factor activity
IXK98_RS06375	COG2814	Major facilitator Superfamily
IXK98_RS06395	COG0697	spore germination
IXK98_RS06405	COG0534	Mate efflux family protein
IXK98_RS06410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXK98_RS06410	COG0475	glutathione-regulated potassium exporter activity
IXK98_RS06415	COG2249	NAD(P)H dehydrogenase (quinone) activity
IXK98_RS06430	COG3604	Transcriptional regulator
IXK98_RS06435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IXK98_RS06435	COG1017	nitric oxide dioxygenase activity
IXK98_RS06450	COG1278	Cold shock
IXK98_RS06455	COG3036	rescue of stalled ribosome
IXK98_RS06470	COG1686	Belongs to the peptidase S11 family
IXK98_RS06490	COG3530	Putative quorum-sensing-regulated virulence factor
IXK98_RS06505	COG4941	Belongs to the sigma-70 factor family
IXK98_RS06510	COG3795	YCII-related domain
IXK98_RS06515	COG1454	alcohol dehydrogenase
IXK98_RS06520	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IXK98_RS06530	COG1011	Hydrolase
IXK98_RS06560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IXK98_RS06570	COG1840	ABC-type Fe3 transport system, periplasmic component
IXK98_RS06580	COG3842	ATPase activity
IXK98_RS06610	COG2866	Carboxypeptidase
IXK98_RS06615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IXK98_RS06620	COG0583	DNA-binding transcription factor activity
IXK98_RS06625	COG1760	l-serine dehydratase
IXK98_RS06645	COG3706	GGDEF domain
IXK98_RS06650	COG0835	chemotaxis
IXK98_RS06650	COG0784	Response regulator, receiver
IXK98_RS06655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXK98_RS06665	COG0737	Belongs to the 5'-nucleotidase family
IXK98_RS06680	COG0494	nUDIX hydrolase
IXK98_RS06690	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IXK98_RS06695	COG2814	Major facilitator Superfamily
IXK98_RS06715	COG2199	diguanylate cyclase activity
IXK98_RS06720	COG1846	Transcriptional regulator
IXK98_RS06725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IXK98_RS06730	COG2176	DNA-directed DNA polymerase activity
IXK98_RS06730	COG5002	protein histidine kinase activity
IXK98_RS06740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IXK98_RS06760	COG0004	ammonium transporteR
IXK98_RS06765	COG4607	ABC-type enterochelin transport system periplasmic component
IXK98_RS06770	COG4206	TonB-dependent receptor
IXK98_RS06800	COG0840	transmembrane signaling receptor activity
IXK98_RS06820	COG0840	transmembrane signaling receptor activity
IXK98_RS06840	COG1115	amino acid carrier protein
IXK98_RS06855	COG0840	transmembrane signaling receptor activity
IXK98_RS06860	COG2199	diguanylate cyclase activity
IXK98_RS06880	COG3706	GGDEF domain
IXK98_RS06895	COG1024	Enoyl-CoA hydratase
IXK98_RS06900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IXK98_RS06905	COG1960	acyl-CoA dehydrogenase activity
IXK98_RS06915	COG0183	Belongs to the thiolase family
IXK98_RS06925	COG1960	acyl-CoA dehydrogenase activity
IXK98_RS06930	COG1024	Enoyl-CoA hydratase
IXK98_RS06935	COG1024	Enoyl-CoA hydratase
IXK98_RS06945	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS06950	COG0840	transmembrane signaling receptor activity
IXK98_RS06960	COG2315	Protein conserved in bacteria
IXK98_RS06970	COG0583	DNA-binding transcription factor activity
IXK98_RS06975	COG0277	FAD linked oxidase domain protein
IXK98_RS06990	COG5001	Diguanylate cyclase
IXK98_RS06990	COG5002	protein histidine kinase activity
IXK98_RS07005	COG0243	molybdopterin cofactor binding
IXK98_RS07010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXK98_RS07010	COG1648	precorrin-2 dehydrogenase activity
IXK98_RS07015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXK98_RS07025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IXK98_RS07025	COG1116	anion transmembrane transporter activity
IXK98_RS07030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IXK98_RS07035	COG1116	anion transmembrane transporter activity
IXK98_RS07040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXK98_RS07040	COG2146	nitrite reductase [NAD(P)H] activity
IXK98_RS07050	COG2197	response regulator
IXK98_RS07100	COG3118	belongs to the thioredoxin family
IXK98_RS07105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXK98_RS07110	COG0420	3'-5' exonuclease activity
IXK98_RS07115	COG0419	ATPase involved in DNA repair
IXK98_RS07120	COG0784	Response regulator, receiver
IXK98_RS07120	COG2205	protein histidine kinase activity
IXK98_RS07125	COG0156	8-amino-7-oxononanoate synthase activity
IXK98_RS07135	COG0038	chloride channel
IXK98_RS07140	COG0523	cobalamin synthesis protein
IXK98_RS07145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IXK98_RS07155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXK98_RS07225	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IXK98_RS07230	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXK98_RS07275	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IXK98_RS07290	COG0840	transmembrane signaling receptor activity
IXK98_RS07295	COG4166	transmembrane transport
IXK98_RS07300	COG4174	ABC transporter (Permease)
IXK98_RS07305	COG4239	(ABC) transporter, permease
IXK98_RS07310	COG4172	Belongs to the ABC transporter superfamily
IXK98_RS07320	COG5001	Diguanylate cyclase
IXK98_RS07350	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IXK98_RS07355	COG4605	iron ion homeostasis
IXK98_RS07360	COG4604	ABC transporter, ATP-binding protein
IXK98_RS07365	COG0789	Transcriptional regulator
IXK98_RS07375	COG3708	Transcriptional regulator
IXK98_RS07375	COG2207	Transcriptional regulator
IXK98_RS07385	COG5001	Diguanylate cyclase
IXK98_RS07385	COG3300	MHYT domain
IXK98_RS07390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IXK98_RS07495	COG1742	UPF0060 membrane protein
IXK98_RS07550	COG3152	Membrane
IXK98_RS07570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXK98_RS07605	COG0625	glutathione transferase activity
IXK98_RS07630	COG4628	conserved protein (DUF2132)
IXK98_RS07655	COG1309	transcriptional regulator
IXK98_RS07660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXK98_RS07680	COG0183	Belongs to the thiolase family
IXK98_RS07695	COG1794	racemase activity, acting on amino acids and derivatives
IXK98_RS07700	COG2814	Major facilitator Superfamily
IXK98_RS07705	COG3240	lipase activity
IXK98_RS07790	COG1328	CTP reductase activity
IXK98_RS07795	COG0602	queuosine metabolic process
IXK98_RS07805	COG0189	ligase activity
IXK98_RS07805	COG4067	protein conserved in archaea
IXK98_RS07810	COG0494	nUDIX hydrolase
IXK98_RS07815	COG0545	Peptidyl-prolyl cis-trans isomerase
IXK98_RS07840	COG2926	Belongs to the UPF0265 family
IXK98_RS07850	COG3132	Protein of unknown function, DUF480
IXK98_RS07855	COG2827	Endonuclease containing a URI domain
IXK98_RS07865	COG1879	ABC-type sugar transport system periplasmic component
IXK98_RS07870	COG2205	protein histidine kinase activity
IXK98_RS07870	COG0784	Response regulator, receiver
IXK98_RS07890	COG1289	transmembrane transporter activity
IXK98_RS07895	COG0210	DNA helicase
IXK98_RS07915	COG0484	heat shock protein binding
IXK98_RS07925	COG1116	anion transmembrane transporter activity
IXK98_RS07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IXK98_RS07935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXK98_RS07945	COG5001	Diguanylate cyclase
IXK98_RS07945	COG1716	ATPase activity
IXK98_RS07950	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IXK98_RS07960	COG4181	ATPase activity
IXK98_RS07965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IXK98_RS07975	COG1984	allophanate hydrolase subunit 2
IXK98_RS07985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IXK98_RS07990	COG5001	Diguanylate cyclase
IXK98_RS07990	COG3300	MHYT domain
IXK98_RS08025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXK98_RS08025	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXK98_RS08030	COG3850	Histidine kinase
IXK98_RS08035	COG2197	response regulator
IXK98_RS08040	COG3069	C4-dicarboxylate transmembrane transporter activity
IXK98_RS08065	COG3038	cytochrome b561
IXK98_RS08070	COG2353	YceI-like domain
IXK98_RS08075	COG2116	formate transmembrane transporter activity
IXK98_RS08080	COG0583	DNA-binding transcription factor activity
IXK98_RS08090	COG3593	DNA synthesis involved in DNA repair
IXK98_RS08095	COG0737	Belongs to the 5'-nucleotidase family
IXK98_RS08125	COG0750	zinc metalloprotease
IXK98_RS08130	COG4783	chaperone-mediated protein folding
IXK98_RS08135	COG2050	protein possibly involved in aromatic compounds catabolism
IXK98_RS08155	COG1629	transport
IXK98_RS08155	COG4771	TonB-dependent receptor
IXK98_RS08160	COG0583	DNA-binding transcription factor activity
IXK98_RS08170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IXK98_RS08175	COG0363	glucosamine-6-phosphate deaminase activity
IXK98_RS08185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IXK98_RS08215	COG0156	8-amino-7-oxononanoate synthase activity
IXK98_RS08255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXK98_RS08260	COG2195	Cleaves the N-terminal amino acid of tripeptides
IXK98_RS08280	COG1716	ATPase activity
IXK98_RS08280	COG5001	Diguanylate cyclase
IXK98_RS08285	COG0798	PFAM Bile acid sodium symporter
IXK98_RS08295	COG0045	succinate-CoA ligase (ADP-forming) activity
IXK98_RS08295	COG1042	CoA-binding domain protein
IXK98_RS08295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXK98_RS08305	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXK98_RS08320	COG0023	Translation Initiation Factor
IXK98_RS08495	COG4128	Pfam Zonular occludens toxin
IXK98_RS08560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IXK98_RS08565	COG1739	Uncharacterized protein family UPF0029
IXK98_RS08575	COG0183	Belongs to the thiolase family
IXK98_RS08580	COG0583	DNA-binding transcription factor activity
IXK98_RS08585	COG2814	Major facilitator Superfamily
IXK98_RS08595	COG0765	amino acid transport
IXK98_RS08605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IXK98_RS08610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IXK98_RS08615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IXK98_RS08625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IXK98_RS08630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IXK98_RS08645	COG3312	ion transport
IXK98_RS08650	COG1475	DNA binding
IXK98_RS08655	COG1192	Involved in chromosome partitioning
IXK98_RS08660	COG0357	Ribosomal RNA small subunit methyltransferase G
IXK98_RS08665	COG0445	tRNA wobble uridine modification
IXK98_RS08670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXK98_RS08675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IXK98_RS08680	COG0706	membrane insertase activity
IXK98_RS08690	COG0594	ribonuclease P activity
IXK98_RS08695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IXK98_RS08700	COG1126	abc transporter atp-binding protein
IXK98_RS08720	COG0592	DNA-directed DNA polymerase activity
IXK98_RS08725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IXK98_RS08730	COG0187	DNA topoisomerase II activity
IXK98_RS08735	COG0071	Belongs to the small heat shock protein (HSP20) family
IXK98_RS08745	COG3977	Valine--pyruvate aminotransferase
IXK98_RS08750	COG0751	glycine-tRNA ligase activity
IXK98_RS08755	COG0752	glycyl-tRNA synthetase alpha subunit
IXK98_RS08760	COG2119	membrane
IXK98_RS08770	COG0425	Belongs to the sulfur carrier protein TusA family
IXK98_RS08785	COG0604	alcohol dehydrogenase
IXK98_RS08795	COG0129	dihydroxy-acid dehydratase activity
IXK98_RS08800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IXK98_RS08805	COG3978	acetolactate synthase activity
IXK98_RS08815	COG0606	chelatase, subunit chli
IXK98_RS08825	COG0204	Acyl-transferase
IXK98_RS08830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXK98_RS08835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IXK98_RS08845	COG3084	Protein conserved in bacteria
IXK98_RS08850	COG4326	sporulation control protein
IXK98_RS08855	COG1272	protein, Hemolysin III
IXK98_RS08860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IXK98_RS08865	COG0569	domain protein
IXK98_RS08870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXK98_RS08870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IXK98_RS08875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IXK98_RS08880	COG0242	peptide deformylase activity
IXK98_RS08885	COG1652	LysM domain
IXK98_RS08890	COG0758	DNA mediated transformation
IXK98_RS08895	COG2922	Belongs to the Smg family
IXK98_RS08900	COG0551	DNA topoisomerase type I activity
IXK98_RS08905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IXK98_RS08910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IXK98_RS08920	COG0408	coproporphyrinogen oxidase activity
IXK98_RS08925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IXK98_RS08935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IXK98_RS08980	COG5001	Diguanylate cyclase
IXK98_RS08980	COG3300	MHYT domain
IXK98_RS08990	COG3852	Histidine kinase
IXK98_RS09000	COG0174	glutamine synthetase
IXK98_RS09005	COG1217	gtp-binding protein TYPA
IXK98_RS09020	COG1295	ribonuclease BN
IXK98_RS09025	COG1490	D-aminoacyl-tRNA deacylase activity
IXK98_RS09030	COG0456	acetyltransferase
IXK98_RS09040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IXK98_RS09045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IXK98_RS09055	COG3031	protein transport across the cell outer membrane
IXK98_RS09065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXK98_RS09070	COG1459	type II secretion system
IXK98_RS09075	COG2165	general secretion pathway protein
IXK98_RS09080	COG2165	general secretion pathway protein
IXK98_RS09085	COG2165	general secretion pathway protein
IXK98_RS09090	COG4795	General secretion pathway protein
IXK98_RS09095	COG3156	type II secretion system protein K
IXK98_RS09100	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IXK98_RS09105	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IXK98_RS09125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXK98_RS09135	COG2183	response to ionizing radiation
IXK98_RS09160	COG0494	nUDIX hydrolase
IXK98_RS09165	COG1218	3'(2'),5'-bisphosphate nucleotidase
IXK98_RS09170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IXK98_RS09175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXK98_RS09180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXK98_RS09185	COG1758	RNA polymerase activity
IXK98_RS09190	COG0194	GDP metabolic process
IXK98_RS09195	COG2252	PERMEase
IXK98_RS09210	COG1561	YicC-like family, N-terminal region
IXK98_RS09215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IXK98_RS09220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IXK98_RS09225	COG1560	Kdo2-lipid A biosynthetic process
IXK98_RS09230	COG1560	Kdo2-lipid A biosynthetic process
IXK98_RS09235	COG1309	transcriptional regulator
IXK98_RS09240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IXK98_RS09245	COG2003	Belongs to the UPF0758 family
IXK98_RS09250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IXK98_RS09270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IXK98_RS09275	COG0859	PFAM glycosyl transferase family 9
IXK98_RS09280	COG0463	Glycosyl transferase, family 2
IXK98_RS09285	COG0859	PFAM glycosyl transferase family 9
IXK98_RS09290	COG3642	lipopolysaccharide core region biosynthetic process
IXK98_RS09320	COG1088	dTDP-glucose 4,6-dehydratase activity
IXK98_RS09325	COG1519	Transferase
IXK98_RS09335	COG0859	PFAM glycosyl transferase family 9
IXK98_RS09350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IXK98_RS09355	COG0673	inositol 2-dehydrogenase activity
IXK98_RS09360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IXK98_RS09380	COG1086	Polysaccharide biosynthesis protein
IXK98_RS09385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IXK98_RS09390	COG1083	cytidylyl-transferase
IXK98_RS09400	COG2089	acid synthase
IXK98_RS09410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IXK98_RS09470	COG0438	transferase activity, transferring glycosyl groups
IXK98_RS09480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IXK98_RS09490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IXK98_RS09495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IXK98_RS09495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IXK98_RS09500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IXK98_RS09530	COG0459	protein refolding
IXK98_RS09535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IXK98_RS09540	COG1573	uracil-dna glycosylase
IXK98_RS09555	COG1253	flavin adenine dinucleotide binding
IXK98_RS09570	COG0151	Belongs to the GarS family
IXK98_RS09575	COG0138	bifunctional purine biosynthesis protein purh
IXK98_RS09580	COG0789	Transcriptional regulator
IXK98_RS09585	COG3706	GGDEF domain
IXK98_RS09590	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IXK98_RS09595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXK98_RS09605	COG0439	Biotin carboxylase
IXK98_RS09610	COG0511	ligase activity, forming carbon-carbon bonds
IXK98_RS09615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IXK98_RS09620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IXK98_RS09635	COG2814	Major facilitator Superfamily
IXK98_RS09640	COG0784	Response regulator, receiver
IXK98_RS09640	COG2205	protein histidine kinase activity
IXK98_RS09650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXK98_RS09660	COG2095	MarC family integral membrane protein
IXK98_RS09670	COG4232	protein-disulfide reductase activity
IXK98_RS09675	COG1438	arginine binding
IXK98_RS09680	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IXK98_RS09685	COG0540	Belongs to the ATCase OTCase family
IXK98_RS09690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IXK98_RS09705	COG1288	antiporter activity
IXK98_RS09710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IXK98_RS09715	COG1027	Aspartate ammonia-lyase
IXK98_RS09735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IXK98_RS09755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXK98_RS09760	COG3954	Phosphoribulokinase
IXK98_RS09765	COG3089	Belongs to the UPF0270 family
IXK98_RS09770	COG0429	hydrolase of the alpha beta-hydrolase fold
IXK98_RS09780	COG0488	(ABC) transporter
IXK98_RS09785	COG2249	NAD(P)H dehydrogenase (quinone) activity
IXK98_RS09795	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IXK98_RS09800	COG1047	Peptidyl-prolyl cis-trans
IXK98_RS09805	COG1446	asparaginase
IXK98_RS09810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IXK98_RS09815	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IXK98_RS09820	COG0402	S-adenosylhomocysteine deaminase activity
IXK98_RS09825	COG0557	exoribonuclease II activity
IXK98_RS09830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IXK98_RS09840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IXK98_RS09845	COG0088	Forms part of the polypeptide exit tunnel
IXK98_RS09860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IXK98_RS09865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IXK98_RS09870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IXK98_RS09885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IXK98_RS09900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IXK98_RS09915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IXK98_RS09930	COG1841	ribosomal large subunit assembly
IXK98_RS09935	COG0200	Binds to the 23S rRNA
IXK98_RS09940	COG0201	protein transport
IXK98_RS09945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IXK98_RS09950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IXK98_RS09955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IXK98_RS09965	COG0202	RNA polymerase activity
IXK98_RS09970	COG0203	ribosomal protein L17
IXK98_RS09980	COG0545	Peptidyl-prolyl cis-trans isomerase
IXK98_RS09995	COG2153	protein acetylation
IXK98_RS10005	COG0737	Belongs to the 5'-nucleotidase family
IXK98_RS10010	COG1648	precorrin-2 dehydrogenase activity
IXK98_RS10010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IXK98_RS10015	COG0175	sulfate reduction
IXK98_RS10025	COG3273	potassium ion transport
IXK98_RS10025	COG0471	metal ion transport
IXK98_RS10030	COG0529	Catalyzes the synthesis of activated sulfate
IXK98_RS10040	COG0735	belongs to the Fur family
IXK98_RS10045	COG2205	protein histidine kinase activity
IXK98_RS10045	COG5002	protein histidine kinase activity
IXK98_RS10045	COG0784	Response regulator, receiver
IXK98_RS10050	COG3437	response regulator, receiver
IXK98_RS10075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IXK98_RS10080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXK98_RS10085	COG0175	sulfate reduction
IXK98_RS10150	COG0646	methionine synthase
IXK98_RS10150	COG1410	methionine synthase
IXK98_RS10160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS10165	COG1660	Displays ATPase and GTPase activities
IXK98_RS10170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS10175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IXK98_RS10185	COG1137	ATPase activity
IXK98_RS10190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IXK98_RS10200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IXK98_RS10205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IXK98_RS10205	COG0517	IMP dehydrogenase activity
IXK98_RS10215	COG1127	ABC transporter
IXK98_RS10220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IXK98_RS10225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IXK98_RS10230	COG2854	intermembrane phospholipid transfer
IXK98_RS10235	COG3113	response to antibiotic
IXK98_RS10240	COG5007	Belongs to the BolA IbaG family
IXK98_RS10250	COG0204	Acyl-transferase
IXK98_RS10315	COG0741	lytic transglycosylase activity
IXK98_RS10320	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IXK98_RS10325	COG1194	a g-specific adenine glycosylase
IXK98_RS10330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IXK98_RS10335	COG2066	Belongs to the glutaminase family
IXK98_RS10340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IXK98_RS10345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IXK98_RS10360	COG0762	integral membrane protein
IXK98_RS10365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IXK98_RS10370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IXK98_RS10390	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IXK98_RS10390	COG1918	ferrous iron import across plasma membrane
IXK98_RS10415	COG1131	(ABC) transporter
IXK98_RS10425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IXK98_RS10430	COG1678	Uncharacterized ACR, COG1678
IXK98_RS10435	COG0189	ligase activity
IXK98_RS10440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IXK98_RS10445	COG2356	endonuclease I
IXK98_RS10460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IXK98_RS10465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IXK98_RS10475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXK98_RS10485	COG0191	fructose-bisphosphate aldolase activity
IXK98_RS10490	COG0668	transmembrane transport
IXK98_RS10505	COG0583	DNA-binding transcription factor activity
IXK98_RS10525	COG0469	pyruvate kinase activity
IXK98_RS10530	COG1349	DNA-binding transcription factor activity
IXK98_RS10535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IXK98_RS10540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IXK98_RS10545	COG3722	fumarate hydratase activity
IXK98_RS10550	COG0246	Mannitol dehydrogenase
IXK98_RS10555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS10555	COG2213	PTS system mannitol-specific
IXK98_RS10560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IXK98_RS10570	COG0142	geranyltranstransferase activity
IXK98_RS10575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IXK98_RS10585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IXK98_RS10590	COG3610	response to peptide
IXK98_RS10620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IXK98_RS10630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IXK98_RS10635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IXK98_RS10640	COG0582	viral genome integration into host DNA
IXK98_RS10715	COG0358	DNA primase activity
IXK98_RS10720	COG1610	YqeY-like protein
IXK98_RS10725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IXK98_RS10730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IXK98_RS10735	COG2267	carboxylic ester hydrolase activity
IXK98_RS10740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IXK98_RS10745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IXK98_RS10750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXK98_RS10755	COG1968	undecaprenyl-diphosphatase activity
IXK98_RS10760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IXK98_RS10765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IXK98_RS10770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IXK98_RS10775	COG0585	pseudouridine synthase activity
IXK98_RS10790	COG1388	LysM domain
IXK98_RS10790	COG4942	peptidase
IXK98_RS10795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IXK98_RS10800	COG4536	flavin adenine dinucleotide binding
IXK98_RS10805	COG4137	Cytochrome C assembly protein
IXK98_RS10810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IXK98_RS10820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IXK98_RS10825	COG0336	Belongs to the RNA methyltransferase TrmD family
IXK98_RS10835	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IXK98_RS10840	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IXK98_RS10845	COG0237	dephospho-CoA kinase activity
IXK98_RS10855	COG1459	type II secretion system
IXK98_RS10860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXK98_RS10870	COG0157	Belongs to the NadC ModD family
IXK98_RS10880	COG0716	FMN binding
IXK98_RS10885	COG4974	Belongs to the 'phage' integrase family
IXK98_RS10890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXK98_RS10895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IXK98_RS10900	COG2186	Transcriptional regulator
IXK98_RS10905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IXK98_RS10910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXK98_RS10915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXK98_RS10930	COG0288	reversible hydration of carbon dioxide
IXK98_RS10935	COG0659	secondary active sulfate transmembrane transporter activity
IXK98_RS10940	COG1131	(ABC) transporter
IXK98_RS10945	COG0842	Transport permease protein
IXK98_RS10960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IXK98_RS10975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IXK98_RS10985	COG1643	Atp-dependent helicase
IXK98_RS10990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IXK98_RS10995	COG1752	Esterase of the alpha-beta hydrolase superfamily
IXK98_RS11005	COG3112	Uncharacterised protein family (UPF0231)
IXK98_RS11020	COG1840	ABC-type Fe3 transport system, periplasmic component
IXK98_RS11030	COG3842	ATPase activity
IXK98_RS11035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IXK98_RS11050	COG2971	BadF BadG BcrA BcrD
IXK98_RS11060	COG4608	Belongs to the ABC transporter superfamily
IXK98_RS11065	COG0444	Belongs to the ABC transporter superfamily
IXK98_RS11070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IXK98_RS11080	COG0747	negative chemotaxis
IXK98_RS11085	COG2205	protein histidine kinase activity
IXK98_RS11085	COG2198	Histidine kinase
IXK98_RS11085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS11085	COG0784	Response regulator, receiver
IXK98_RS11090	COG2813	Specifically methylates the guanine in position
IXK98_RS11095	COG0628	permease
IXK98_RS11100	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IXK98_RS11120	COG0739	heme binding
IXK98_RS11125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IXK98_RS11135	COG2027	D-alanyl-D-alanine carboxypeptidase
IXK98_RS11140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IXK98_RS11145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IXK98_RS11150	COG1534	Rna-binding protein
IXK98_RS11160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IXK98_RS11165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IXK98_RS11180	COG0456	acetyltransferase
IXK98_RS11190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IXK98_RS11195	COG0513	Belongs to the DEAD box helicase family
IXK98_RS11200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IXK98_RS11215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IXK98_RS11220	COG2204	response regulator
IXK98_RS11230	COG0667	Aldo Keto reductase
IXK98_RS11240	COG3066	DNA modification
IXK98_RS11245	COG0494	nUDIX hydrolase
IXK98_RS11255	COG0730	response to heat
IXK98_RS11260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IXK98_RS11265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IXK98_RS11270	COG1283	sodium-dependent phosphate transmembrane transporter activity
IXK98_RS11275	COG0583	DNA-binding transcription factor activity
IXK98_RS11280	COG0640	Transcriptional regulator
IXK98_RS11285	COG0268	Binds directly to 16S ribosomal RNA
IXK98_RS11290	COG0728	peptidoglycan biosynthetic process
IXK98_RS11295	COG0196	riboflavin kinase activity
IXK98_RS11310	COG1047	Peptidyl-prolyl cis-trans
IXK98_RS11315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IXK98_RS11320	COG0612	Peptidase, M16
IXK98_RS11325	COG1966	Carbon starvation protein
IXK98_RS11335	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IXK98_RS11340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IXK98_RS11350	COG3279	Response regulator of the LytR AlgR family
IXK98_RS11355	COG3275	phosphorelay sensor kinase activity
IXK98_RS11360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXK98_RS11365	COG1605	Chorismate mutase
IXK98_RS11365	COG0287	Prephenate dehydrogenase
IXK98_RS11370	COG0739	heme binding
IXK98_RS11380	COG0488	(ABC) transporter
IXK98_RS11390	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IXK98_RS11395	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IXK98_RS11400	COG5001	Diguanylate cyclase
IXK98_RS11405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IXK98_RS11410	COG0077	Prephenate dehydratase
IXK98_RS11410	COG1605	Chorismate mutase
IXK98_RS11415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IXK98_RS11420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IXK98_RS11425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXK98_RS11430	COG0564	pseudouridine synthase activity
IXK98_RS11435	COG1496	oxidoreductase activity
IXK98_RS11440	COG0542	response to heat
IXK98_RS11485	COG0483	inositol monophosphate 1-phosphatase activity
IXK98_RS11500	COG1104	cysteine desulfurase activity
IXK98_RS11505	COG0822	iron-sulfur transferase activity
IXK98_RS11525	COG0633	Ferredoxin
IXK98_RS11530	COG2975	iron-sulfur cluster assembly
IXK98_RS11535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IXK98_RS11545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IXK98_RS11550	COG0583	DNA-binding transcription factor activity
IXK98_RS11560	COG0583	DNA-binding transcription factor activity
IXK98_RS11565	COG1022	Amp-dependent synthetase and ligase
IXK98_RS11570	COG2169	Transcriptional regulator
IXK98_RS11600	COG4964	Belongs to the GSP D family
IXK98_RS11640	COG0583	DNA-binding transcription factor activity
IXK98_RS11650	COG1175	transmembrane transport
IXK98_RS11655	COG0395	ABC-type sugar transport system, permease component
IXK98_RS11660	COG1653	transport
IXK98_RS11665	COG3250	beta-galactosidase activity
IXK98_RS11675	COG3408	Glycogen debranching enzyme
IXK98_RS11675	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IXK98_RS11680	COG2207	Transcriptional regulator
IXK98_RS11680	COG0662	Cupin 2, conserved barrel domain protein
IXK98_RS11705	COG0531	amino acid
IXK98_RS11710	COG2731	YhcH YjgK YiaL family protein
IXK98_RS11715	COG3250	beta-galactosidase activity
IXK98_RS11720	COG1609	Transcriptional regulator
IXK98_RS11725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IXK98_RS11730	COG1085	galactose-1-phosphate uridylyltransferase
IXK98_RS11740	COG2017	converts alpha-aldose to the beta-anomer
IXK98_RS11760	COG0583	DNA-binding transcription factor activity
IXK98_RS11765	COG4989	oxidoreductase activity
IXK98_RS11775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXK98_RS11790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IXK98_RS11795	COG1349	DNA-binding transcription factor activity
IXK98_RS11800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IXK98_RS11805	COG2271	Major facilitator Superfamily
IXK98_RS11810	COG2171	N-acyltransferase activity
IXK98_RS11815	COG0450	alkyl hydroperoxide reductase
IXK98_RS11820	COG0583	DNA-binding transcription factor activity
IXK98_RS11825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IXK98_RS11835	COG0517	IMP dehydrogenase activity
IXK98_RS11840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IXK98_RS11850	COG1862	Preprotein translocase
IXK98_RS11855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXK98_RS11860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IXK98_RS11870	COG1879	ABC-type sugar transport system periplasmic component
IXK98_RS11885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IXK98_RS11890	COG0826	peptidase U32
IXK98_RS11900	COG0745	RESPONSE REGULATOR receiver
IXK98_RS11905	COG5002	protein histidine kinase activity
IXK98_RS11915	COG0248	Ppx GppA phosphatase
IXK98_RS11920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IXK98_RS11925	COG0573	inorganic phosphate transmembrane transporter activity
IXK98_RS11930	COG0581	inorganic phosphate transmembrane transporter activity
IXK98_RS11935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IXK98_RS11940	COG0704	Plays a role in the regulation of phosphate uptake
IXK98_RS11965	COG3142	Participates in the control of copper homeostasis
IXK98_RS11970	COG3141	response to X-ray
IXK98_RS11975	COG1309	transcriptional regulator
IXK98_RS11980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXK98_RS12000	COG3284	Transcriptional regulator
IXK98_RS12005	COG3842	ATPase activity
IXK98_RS12010	COG3842	ATPase activity
IXK98_RS12020	COG0395	ABC-type sugar transport system, permease component
IXK98_RS12035	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IXK98_RS12040	COG1074	ATP-dependent DNA helicase activity
IXK98_RS12045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IXK98_RS12055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IXK98_RS12055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXK98_RS12065	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IXK98_RS12070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IXK98_RS12075	COG2166	iron-sulfur cluster assembly
IXK98_RS12090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IXK98_RS12095	COG0124	histidyl-tRNA synthetase
IXK98_RS12100	COG2976	Protein conserved in bacteria
IXK98_RS12105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXK98_RS12110	COG1160	GTP binding
IXK98_RS12120	COG3706	GGDEF domain
IXK98_RS12135	COG0516	GMP reductase activity
IXK98_RS12135	COG0517	IMP dehydrogenase activity
IXK98_RS12140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IXK98_RS12140	COG0519	Catalyzes the synthesis of GMP from XMP
IXK98_RS12150	COG1584	GPR1 FUN34 yaaH family protein
IXK98_RS12155	COG1115	amino acid carrier protein
IXK98_RS12185	COG2873	o-acetylhomoserine
IXK98_RS12190	COG1253	flavin adenine dinucleotide binding
IXK98_RS12195	COG0583	DNA-binding transcription factor activity
IXK98_RS12205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IXK98_RS12210	COG0204	Acyl-transferase
IXK98_RS12215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IXK98_RS12230	COG0668	transmembrane transport
IXK98_RS12250	COG0009	L-threonylcarbamoyladenylate synthase
IXK98_RS12255	COG0579	oxidoreductase
IXK98_RS12260	COG1473	amidohydrolase
IXK98_RS12270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IXK98_RS12290	COG2271	Major facilitator Superfamily
IXK98_RS12295	COG3851	Histidine kinase
IXK98_RS12300	COG2197	response regulator
IXK98_RS12325	COG2867	negative regulation of translational initiation
IXK98_RS12330	COG2914	Belongs to the UPF0125 (RnfH) family
IXK98_RS12335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXK98_RS12340	COG0497	DNA recombination
IXK98_RS12345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IXK98_RS12350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IXK98_RS12355	COG1301	dicarboxylic acid transport
IXK98_RS12370	COG0443	Heat shock 70 kDa protein
IXK98_RS12375	COG0484	heat shock protein binding
IXK98_RS12405	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IXK98_RS12420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IXK98_RS12425	COG0047	phosphoribosylformylglycinamidine synthase activity
IXK98_RS12425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IXK98_RS12450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IXK98_RS12455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IXK98_RS12460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IXK98_RS12470	COG2840	Smr protein MutS2
IXK98_RS12500	COG3104	oligopeptide transport
IXK98_RS12505	COG0367	asparagine synthase
IXK98_RS12510	COG4651	solute:proton antiporter activity
IXK98_RS12510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IXK98_RS12515	COG1940	carbohydrate kinase activity
IXK98_RS12515	COG1846	Transcriptional regulator
IXK98_RS12520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IXK98_RS12525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS12525	COG1263	PTS System
IXK98_RS12525	COG2190	(PTS) system
IXK98_RS12530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IXK98_RS12535	COG0735	belongs to the Fur family
IXK98_RS12545	COG0716	FMN binding
IXK98_RS12555	COG0596	Alpha beta hydrolase
IXK98_RS12560	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IXK98_RS12565	COG0033	Phosphoglucomutase
IXK98_RS12575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IXK98_RS12590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IXK98_RS12595	COG1053	succinate dehydrogenase
IXK98_RS12605	COG0567	Dehydrogenase, E1 component
IXK98_RS12610	COG0508	dehydrogenase complex catalyzes the overall conversion of
IXK98_RS12615	COG0045	succinate-CoA ligase (ADP-forming) activity
IXK98_RS12645	COG3098	single-species biofilm formation
IXK98_RS12650	COG0564	pseudouridine synthase activity
IXK98_RS12660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IXK98_RS12665	COG0142	geranyltranstransferase activity
IXK98_RS12675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IXK98_RS12685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXK98_RS12685	COG0301	tRNA thio-modification
IXK98_RS12690	COG0583	DNA-binding transcription factor activity
IXK98_RS12700	COG2363	Small membrane protein
IXK98_RS12705	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IXK98_RS12715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXK98_RS12735	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXK98_RS12735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IXK98_RS12745	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IXK98_RS12755	COG1876	peptidase activity
IXK98_RS12760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXK98_RS12765	COG1393	Belongs to the ArsC family
IXK98_RS12785	COG4235	cytochrome complex assembly
IXK98_RS12790	COG4221	oxidoreductase activity
IXK98_RS12795	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IXK98_RS12805	COG0437	4 iron, 4 sulfur cluster binding
IXK98_RS12810	COG3301	Polysulphide reductase, NrfD
IXK98_RS12815	COG1138	Cytochrome C-type biogenesis protein
IXK98_RS12820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXK98_RS12825	COG3088	subunit of a heme lyase
IXK98_RS12825	COG4235	cytochrome complex assembly
IXK98_RS12840	COG2837	iron assimilation
IXK98_RS12855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXK98_RS12865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IXK98_RS12875	COG1516	flagellar protein fliS
IXK98_RS12895	COG1677	Flagellar hook-basal body complex protein FliE
IXK98_RS12905	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IXK98_RS12930	COG1580	Controls the rotational direction of flagella during chemotaxis
IXK98_RS12955	COG1987	bacterial-type flagellum assembly
IXK98_RS12960	COG1684	flagellar biosynthetic protein fliR
IXK98_RS12975	COG2890	protein-(glutamine-N5) methyltransferase activity
IXK98_RS12980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IXK98_RS12985	COG0737	Belongs to the 5'-nucleotidase family
IXK98_RS12995	COG2860	membrane
IXK98_RS13000	COG3101	peptidyl-lysine hydroxylation
IXK98_RS13020	COG0431	NADPH-dependent FMN reductase
IXK98_RS13030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IXK98_RS13035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXK98_RS13040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXK98_RS13050	COG0101	tRNA pseudouridine synthase activity
IXK98_RS13055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXK98_RS13060	COG0285	dihydrofolate synthase activity
IXK98_RS13065	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IXK98_RS13070	COG1286	toxin biosynthetic process
IXK98_RS13075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IXK98_RS13080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IXK98_RS13085	COG1121	(ABC) transporter
IXK98_RS13090	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IXK98_RS13095	COG4977	sequence-specific DNA binding
IXK98_RS13105	COG1918	ferrous iron import across plasma membrane
IXK98_RS13110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IXK98_RS13125	COG0018	arginyl-trna synthetase
IXK98_RS13135	COG3102	Protein conserved in bacteria
IXK98_RS13145	COG2062	phosphohistidine phosphatase, SixA
IXK98_RS13175	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IXK98_RS13180	COG2198	Histidine kinase
IXK98_RS13180	COG0784	Response regulator, receiver
IXK98_RS13180	COG0643	Histidine kinase
IXK98_RS13190	COG1192	Involved in chromosome partitioning
IXK98_RS13200	COG0835	chemotaxis
IXK98_RS13210	COG4133	protoheme IX ABC transporter activity
IXK98_RS13215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXK98_RS13220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXK98_RS13225	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IXK98_RS13230	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IXK98_RS13235	COG1138	Cytochrome C-type biogenesis protein
IXK98_RS13240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IXK98_RS13245	COG4235	cytochrome complex assembly
IXK98_RS13245	COG3088	subunit of a heme lyase
IXK98_RS13260	COG2067	long-chain fatty acid transport protein
IXK98_RS13280	COG0183	Belongs to the thiolase family
IXK98_RS13285	COG1250	3-hydroxyacyl-CoA dehydrogenase
IXK98_RS13285	COG1024	Enoyl-CoA hydratase
IXK98_RS13290	COG0778	Nitroreductase
IXK98_RS13300	COG0745	RESPONSE REGULATOR receiver
IXK98_RS13305	COG2832	Protein of unknown function (DUF454)
IXK98_RS13310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IXK98_RS13325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IXK98_RS13395	COG3829	transcription factor binding
IXK98_RS13420	COG2983	Belongs to the UPF0260 family
IXK98_RS13460	COG0668	transmembrane transport
IXK98_RS13495	COG2226	methyltransferase
IXK98_RS13510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXK98_RS13515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXK98_RS13525	COG3139	Protein of unknown function (DUF1315)
IXK98_RS13530	COG3012	SEC-C Motif Domain Protein
IXK98_RS13535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IXK98_RS13540	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXK98_RS13545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IXK98_RS13550	COG0215	cysteine-tRNA ligase activity
IXK98_RS13560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IXK98_RS13565	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IXK98_RS13580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IXK98_RS13590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXK98_RS13600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IXK98_RS13605	COG0297	glycogen (starch) synthase activity
IXK98_RS13625	COG3070	regulator of competence-specific genes
IXK98_RS13630	COG1609	Transcriptional regulator
IXK98_RS13640	COG0745	RESPONSE REGULATOR receiver
IXK98_RS13645	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IXK98_RS13650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXK98_RS13660	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IXK98_RS13665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IXK98_RS13680	COG0318	PFAM AMP-dependent synthetase and ligase
IXK98_RS13700	COG4067	protein conserved in archaea
IXK98_RS13700	COG0189	ligase activity
IXK98_RS13715	COG1801	Protein of unknown function DUF72
IXK98_RS13725	COG1187	pseudouridine synthase activity
IXK98_RS13735	COG1278	Cold shock
IXK98_RS13745	COG0542	response to heat
IXK98_RS13780	COG2116	formate transmembrane transporter activity
IXK98_RS13790	COG0390	transport system, permease component
IXK98_RS13795	COG4459	periplasmic nitrate reductase
IXK98_RS13800	COG3005	denitrification pathway
IXK98_RS13805	COG0243	molybdopterin cofactor binding
IXK98_RS13835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IXK98_RS13840	COG0840	transmembrane signaling receptor activity
IXK98_RS13845	COG0632	four-way junction helicase activity
IXK98_RS13850	COG2255	four-way junction helicase activity
IXK98_RS13860	COG1294	oxidase, subunit
IXK98_RS13865	COG4890	Cyd operon protein YbgT
IXK98_RS13875	COG0824	Thioesterase
IXK98_RS13880	COG0811	peptide transport
IXK98_RS13895	COG0823	Involved in the tonB-independent uptake of proteins
IXK98_RS13900	COG2885	chlorophyll binding
IXK98_RS13905	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IXK98_RS13910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IXK98_RS13915	COG0137	argininosuccinate synthase activity
IXK98_RS13925	COG2205	protein histidine kinase activity
IXK98_RS13925	COG0784	Response regulator, receiver
IXK98_RS13940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS13950	COG1482	cell wall glycoprotein biosynthetic process
IXK98_RS13955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS13955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS13955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS13960	COG2207	Transcriptional regulator
IXK98_RS13970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS13975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IXK98_RS13980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IXK98_RS13995	COG3850	Histidine kinase
IXK98_RS13995	COG5002	protein histidine kinase activity
IXK98_RS14000	COG0745	RESPONSE REGULATOR receiver
IXK98_RS14005	COG0463	Glycosyl transferase, family 2
IXK98_RS14010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IXK98_RS14025	COG1960	acyl-CoA dehydrogenase activity
IXK98_RS14040	COG0840	transmembrane signaling receptor activity
IXK98_RS14045	COG2850	peptidyl-arginine hydroxylation
IXK98_RS14055	COG3923	Primosomal replication protein n
IXK98_RS14060	COG0730	response to heat
IXK98_RS14065	COG1199	ATP-dependent helicase activity
IXK98_RS14075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IXK98_RS14080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IXK98_RS14090	COG0156	8-amino-7-oxononanoate synthase activity
IXK98_RS14095	COG2226	methyltransferase
IXK98_RS14100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IXK98_RS14110	COG0501	Belongs to the peptidase M48B family
IXK98_RS14120	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IXK98_RS14135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXK98_RS14145	COG2268	Band 7 protein
IXK98_RS14155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IXK98_RS14175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXK98_RS14185	COG1757	Na H antiporter
IXK98_RS14195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IXK98_RS14205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXK98_RS14205	COG0131	Imidazoleglycerol-phosphate dehydratase
IXK98_RS14210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IXK98_RS14215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IXK98_RS14225	COG0140	phosphoribosyl-ATP diphosphatase activity
IXK98_RS14225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IXK98_RS14235	COG1227	inorganic diphosphatase activity
IXK98_RS14250	COG4172	Belongs to the ABC transporter superfamily
IXK98_RS14275	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IXK98_RS14280	COG1842	Phage shock protein A
IXK98_RS14310	COG0519	Catalyzes the synthesis of GMP from XMP
IXK98_RS14315	COG5380	lipid catabolic process
IXK98_RS14320	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IXK98_RS14325	COG0626	cystathionine gamma-synthase activity
IXK98_RS14335	COG0733	neurotransmitter:sodium symporter activity
IXK98_RS14345	COG0564	pseudouridine synthase activity
IXK98_RS14350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXK98_RS14370	COG4964	Belongs to the GSP D family
IXK98_RS14425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IXK98_RS14430	COG4136	ATPase activity
IXK98_RS14435	COG4135	transport system, permease component
IXK98_RS14440	COG4134	Bacterial extracellular solute-binding protein
IXK98_RS14450	COG3313	Fe-S protein
IXK98_RS14480	COG2350	Protein conserved in bacteria
IXK98_RS14485	COG1607	acyl-coa hydrolase
IXK98_RS14515	COG0776	regulation of translation
IXK98_RS14525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXK98_RS14535	COG0417	DNA replication proofreading
IXK98_RS14540	COG2197	response regulator
IXK98_RS14545	COG0322	excinuclease ABC activity
IXK98_RS14575	COG3706	GGDEF domain
IXK98_RS14580	COG2133	pyrroloquinoline quinone binding
IXK98_RS14620	COG0456	acetyltransferase
IXK98_RS14630	COG0072	phenylalanine-tRNA ligase activity
IXK98_RS14630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXK98_RS14640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXK98_RS14655	COG2176	DNA-directed DNA polymerase activity
IXK98_RS14660	COG0517	IMP dehydrogenase activity
IXK98_RS14665	COG2186	Transcriptional regulator
IXK98_RS14670	COG2186	Transcriptional regulator
IXK98_RS14695	COG1917	Cupin 2, conserved barrel domain protein
IXK98_RS14700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXK98_RS14705	COG0800	Aldolase
IXK98_RS14710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IXK98_RS14715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IXK98_RS14725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXK98_RS14725	COG0072	phenylalanine-tRNA ligase activity
IXK98_RS14730	COG1172	Belongs to the binding-protein-dependent transport system permease family
IXK98_RS14735	COG1172	Belongs to the binding-protein-dependent transport system permease family
IXK98_RS14740	COG1129	ABC transporter
IXK98_RS14755	COG0667	Aldo Keto reductase
IXK98_RS14760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IXK98_RS14775	COG1454	alcohol dehydrogenase
IXK98_RS14790	COG1414	Transcriptional regulator
IXK98_RS14795	COG1414	Transcriptional regulator
IXK98_RS14800	COG3386	PFAM SMP-30 Gluconolaconase
IXK98_RS14815	COG1741	Belongs to the pirin family
IXK98_RS14825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS14825	COG1263	PTS System
IXK98_RS14830	COG1609	Transcriptional regulator
IXK98_RS14835	COG1621	beta-fructofuranosidase activity
IXK98_RS14840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IXK98_RS14860	COG0583	DNA-binding transcription factor activity
IXK98_RS14880	COG1335	isochorismatase
IXK98_RS14895	COG0346	lactoylglutathione lyase activity
IXK98_RS14940	COG1605	Chorismate mutase
IXK98_RS14945	COG2824	Alkylphosphonate utilization operon protein PhnA
IXK98_RS14950	COG0789	Transcriptional regulator
IXK98_RS14955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IXK98_RS14965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXK98_RS14970	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS15020	COG0456	acetyltransferase
IXK98_RS15105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IXK98_RS15110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IXK98_RS15115	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS15130	COG1115	amino acid carrier protein
IXK98_RS15160	COG2195	Cleaves the N-terminal amino acid of tripeptides
IXK98_RS15170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IXK98_RS15180	COG0625	glutathione transferase activity
IXK98_RS15200	COG2885	chlorophyll binding
IXK98_RS15215	COG0277	FAD linked oxidase domain protein
IXK98_RS15215	COG0247	lactate metabolic process
IXK98_RS15230	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IXK98_RS15235	COG2986	histidine ammonia-lyase
IXK98_RS15240	COG0010	Belongs to the arginase family
IXK98_RS15245	COG1228	amidohydrolase
IXK98_RS15250	COG2188	Transcriptional regulator
IXK98_RS15255	COG4326	sporulation control protein
IXK98_RS15270	COG0500	methyltransferase
IXK98_RS15285	COG0295	cytidine deaminase activity
IXK98_RS15290	COG1346	cytolysis
IXK98_RS15295	COG1380	Effector of murein hydrolase LrgA
IXK98_RS15300	COG2925	Exonuclease
IXK98_RS15335	COG1823	symporter activity
IXK98_RS15340	COG0702	epimerase
IXK98_RS15345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IXK98_RS15350	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IXK98_RS15355	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IXK98_RS15380	COG4139	cobalamin transport
IXK98_RS15385	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IXK98_RS15410	COG0583	DNA-binding transcription factor activity
IXK98_RS15415	COG1119	ATPase activity
IXK98_RS15430	COG1451	nucleotide metabolic process
IXK98_RS15440	COG3063	Type IV pilus biogenesis stability protein PilW
IXK98_RS15445	COG2267	carboxylic ester hydrolase activity
IXK98_RS15450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IXK98_RS15480	COG2095	MarC family integral membrane protein
IXK98_RS15495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXK98_RS15505	COG2153	protein acetylation
IXK98_RS15525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IXK98_RS15650	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IXK98_RS15655	COG0372	Belongs to the citrate synthase family
IXK98_RS15665	COG2828	Protein conserved in bacteria
IXK98_RS15690	COG0561	phosphatase activity
IXK98_RS15695	COG0602	queuosine metabolic process
IXK98_RS15705	COG3706	GGDEF domain
IXK98_RS15730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXK98_RS15735	COG0840	transmembrane signaling receptor activity
IXK98_RS15740	COG1254	Belongs to the acylphosphatase family
IXK98_RS15745	COG2920	part of a sulfur-relay system
IXK98_RS15750	COG0670	Belongs to the BI1 family
IXK98_RS15755	COG1126	abc transporter atp-binding protein
IXK98_RS15760	COG0765	amino acid transport
IXK98_RS15765	COG4597	amino acid ABC transporter
IXK98_RS15770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS15780	COG1666	GTP binding
IXK98_RS15785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IXK98_RS15810	COG3008	intermembrane lipid transfer
IXK98_RS15815	COG2995	paraquat-inducible protein a
IXK98_RS15820	COG1132	(ABC) transporter
IXK98_RS15825	COG1956	GAF domain-containing protein
IXK98_RS15830	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IXK98_RS15845	COG0308	aminopeptidase N
IXK98_RS15870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IXK98_RS15870	COG0116	Belongs to the methyltransferase superfamily
IXK98_RS15880	COG0488	(ABC) transporter
IXK98_RS15895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IXK98_RS15900	COG1067	ATP-dependent peptidase activity
IXK98_RS15905	COG3120	sequence-specific DNA binding
IXK98_RS15930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IXK98_RS15935	COG2226	methyltransferase
IXK98_RS16100	COG3278	Belongs to the heme-copper respiratory oxidase family
IXK98_RS16115	COG2010	Cytochrome c
IXK98_RS16125	COG2217	Heavy metal translocating P-type atpase
IXK98_RS16140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXK98_RS16145	COG0589	response to stress
IXK98_RS16150	COG0037	tRNA processing
IXK98_RS16155	COG0534	Mate efflux family protein
IXK98_RS16175	COG3842	ATPase activity
IXK98_RS16185	COG1177	transmembrane transport
IXK98_RS16190	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IXK98_RS16195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IXK98_RS16200	COG2199	diguanylate cyclase activity
IXK98_RS16205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IXK98_RS16210	COG0004	ammonium transporteR
IXK98_RS16225	COG0437	4 iron, 4 sulfur cluster binding
IXK98_RS16230	COG0243	molybdopterin cofactor binding
IXK98_RS16230	COG3383	formate dehydrogenase (NAD+) activity
IXK98_RS16260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IXK98_RS16270	COG3040	lipid binding
IXK98_RS16305	COG2026	Addiction module toxin, RelE StbE family
IXK98_RS16330	COG2801	Transposase and inactivated derivatives
IXK98_RS16345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXK98_RS16345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXK98_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS16390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXK98_RS16390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXK98_RS16470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXK98_RS16470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IXK98_RS16510	COG0488	(ABC) transporter
IXK98_RS16525	COG2204	response regulator
IXK98_RS16535	COG4662	Binding-protein-dependent transport system inner membrane component
IXK98_RS16540	COG3842	ATPase activity
IXK98_RS16545	COG0746	molybdenum cofactor guanylyltransferase activity
IXK98_RS16550	COG0303	'Molybdopterin
IXK98_RS16560	COG1940	carbohydrate kinase activity
IXK98_RS16565	COG3148	PFAM DTW domain containing protein
IXK98_RS16575	COG0840	transmembrane signaling receptor activity
IXK98_RS16580	COG0791	NLP P60 protein
IXK98_RS16600	COG0307	riboflavin synthase, alpha
IXK98_RS16605	COG0534	Mate efflux family protein
IXK98_RS16620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IXK98_RS16620	COG2885	chlorophyll binding
IXK98_RS16655	COG0438	transferase activity, transferring glycosyl groups
IXK98_RS16690	COG0438	transferase activity, transferring glycosyl groups
IXK98_RS16700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IXK98_RS16715	COG2205	protein histidine kinase activity
IXK98_RS16720	COG0745	RESPONSE REGULATOR receiver
IXK98_RS16740	COG3033	Beta-eliminating lyase
IXK98_RS16755	COG0745	RESPONSE REGULATOR receiver
IXK98_RS16760	COG0814	amino acid
IXK98_RS16765	COG1475	DNA binding
IXK98_RS16770	COG3969	phosphoadenosine phosphosulfate
IXK98_RS16810	COG2116	formate transmembrane transporter activity
IXK98_RS16820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IXK98_RS16825	COG0840	transmembrane signaling receptor activity
IXK98_RS16860	COG4565	transcriptional regulatory protein
IXK98_RS16865	COG3290	protein histidine kinase activity
IXK98_RS16880	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IXK98_RS16885	COG0848	biopolymer transport protein
IXK98_RS16890	COG0811	peptide transport
IXK98_RS16895	COG0811	peptide transport
IXK98_RS16915	COG0745	RESPONSE REGULATOR receiver
IXK98_RS16925	COG0039	L-malate dehydrogenase activity
IXK98_RS16935	COG0584	glycerophosphoryl diester phosphodiesterase
IXK98_RS16945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IXK98_RS16965	COG0583	DNA-binding transcription factor activity
IXK98_RS16970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IXK98_RS16975	COG1328	CTP reductase activity
IXK98_RS16980	COG0840	transmembrane signaling receptor activity
IXK98_RS16995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IXK98_RS17000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXK98_RS17035	COG0019	diaminopimelate decarboxylase activity
IXK98_RS17075	COG0577	efflux transmembrane transporter activity
IXK98_RS17080	COG4181	ATPase activity
IXK98_RS17085	COG0534	Mate efflux family protein
IXK98_RS17090	COG0702	epimerase
IXK98_RS17100	COG2814	Major facilitator Superfamily
IXK98_RS17110	COG1061	Type III restriction enzyme res subunit
IXK98_RS17140	COG3710	Transcriptional regulator
IXK98_RS17145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXK98_RS17150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXK98_RS17170	COG4589	Belongs to the CDS family
IXK98_RS17195	COG3501	Rhs element vgr protein
IXK98_RS17205	COG0463	Glycosyl transferase, family 2
IXK98_RS17215	COG0109	protoheme IX farnesyltransferase activity
IXK98_RS17220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IXK98_RS17225	COG1845	cytochrome c oxidase, subunit III
IXK98_RS17230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IXK98_RS17235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IXK98_RS17250	COG0583	DNA-binding transcription factor activity
IXK98_RS17255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IXK98_RS17270	COG0523	cobalamin synthesis protein
IXK98_RS17285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IXK98_RS17290	COG1780	Probably involved in ribonucleotide reductase function
IXK98_RS17300	COG0316	Belongs to the HesB IscA family
IXK98_RS17305	COG0719	Fe-S assembly protein
IXK98_RS17310	COG0396	ATPase activity
IXK98_RS17315	COG0719	Fe-S assembly protein
IXK98_RS17330	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IXK98_RS17365	COG1858	cytochrome C peroxidase
IXK98_RS17370	COG0784	Response regulator, receiver
IXK98_RS17370	COG2205	protein histidine kinase activity
IXK98_RS17395	COG3501	Rhs element vgr protein
IXK98_RS17405	COG2962	Rard protein
IXK98_RS17410	COG0531	amino acid
IXK98_RS17420	COG4667	esterase of the alpha-beta hydrolase superfamily
IXK98_RS17455	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IXK98_RS17470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXK98_RS17475	COG3108	Peptidase M15
IXK98_RS17480	COG2989	Protein conserved in bacteria
IXK98_RS17505	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IXK98_RS17530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXK98_RS17545	COG3106	COG3106 Predicted ATPase
IXK98_RS17560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXK98_RS17565	COG2205	protein histidine kinase activity
IXK98_RS17565	COG0784	Response regulator, receiver
IXK98_RS17575	COG0494	nUDIX hydrolase
IXK98_RS17580	COG0814	amino acid
IXK98_RS17585	COG1760	l-serine dehydratase
IXK98_RS17595	COG2356	endonuclease I
IXK98_RS17600	COG0814	amino acid
IXK98_RS17610	COG0659	secondary active sulfate transmembrane transporter activity
IXK98_RS17620	COG0840	transmembrane signaling receptor activity
IXK98_RS17625	COG0017	Asparaginyl-tRNA synthetase
IXK98_RS17640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IXK98_RS17650	COG3437	response regulator, receiver
IXK98_RS17650	COG2770	Histidine kinase
IXK98_RS17655	COG1448	Aminotransferase
IXK98_RS17675	COG1643	Atp-dependent helicase
IXK98_RS17680	COG0281	malic enzyme
IXK98_RS17690	COG2949	membrane
IXK98_RS17695	COG3706	GGDEF domain
IXK98_RS17705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXK98_RS17715	COG0492	ferredoxin-NADP+ reductase activity
IXK98_RS17720	COG4988	ABC transporter
IXK98_RS17725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXK98_RS17730	COG5001	Diguanylate cyclase
IXK98_RS17730	COG2203	Gaf domain
IXK98_RS17730	COG4251	negative regulation of phosphorylation
IXK98_RS17730	COG3706	GGDEF domain
IXK98_RS17740	COG1187	pseudouridine synthase activity
IXK98_RS17745	COG0009	L-threonylcarbamoyladenylate synthase
IXK98_RS17750	COG0613	PHP domain protein
IXK98_RS17760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IXK98_RS17765	COG0512	Glutamine amidotransferase of anthranilate synthase
IXK98_RS17770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IXK98_RS17775	COG0135	phosphoribosylanthranilate isomerase activity
IXK98_RS17775	COG0134	indole-3-glycerol-phosphate synthase activity
IXK98_RS17785	COG0159	tryptophan synthase activity
IXK98_RS17790	COG1301	dicarboxylic acid transport
IXK98_RS17810	COG1643	Atp-dependent helicase
IXK98_RS17840	COG3706	GGDEF domain
IXK98_RS17850	COG0443	Heat shock 70 kDa protein
IXK98_RS17855	COG0443	Heat shock 70 kDa protein
IXK98_RS17880	COG0457	Tetratricopeptide repeat
IXK98_RS17950	COG4790	Type iii secretion
IXK98_RS17955	COG4794	Type iii secretion
IXK98_RS17960	COG4791	protein targeting
IXK98_RS17965	COG4792	protein secretion
IXK98_RS18000	COG4669	(LipO)protein
IXK98_RS18035	COG1450	Type ii and iii secretion system protein
IXK98_RS18070	COG1054	Belongs to the UPF0176 family
IXK98_RS18100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IXK98_RS18110	COG0673	inositol 2-dehydrogenase activity
IXK98_RS18120	COG0583	DNA-binding transcription factor activity
IXK98_RS18130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXK98_RS18135	COG1846	Transcriptional regulator
IXK98_RS18140	COG1764	response to oxidative stress
IXK98_RS18145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IXK98_RS18170	COG5001	Diguanylate cyclase
IXK98_RS18170	COG3300	MHYT domain
IXK98_RS18175	COG1032	radical SAM domain protein
IXK98_RS18180	COG5001	Diguanylate cyclase
IXK98_RS18180	COG3300	MHYT domain
IXK98_RS18185	COG2201	protein-glutamate methylesterase activity
IXK98_RS18190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXK98_RS18200	COG0835	chemotaxis
IXK98_RS18205	COG0840	transmembrane signaling receptor activity
IXK98_RS18210	COG0643	Histidine kinase
IXK98_RS18210	COG2198	Histidine kinase
IXK98_RS18220	COG0745	RESPONSE REGULATOR receiver
IXK98_RS18230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IXK98_RS18240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IXK98_RS18240	COG4191	Histidine kinase
IXK98_RS18255	COG3070	regulator of competence-specific genes
IXK98_RS18265	COG2431	L-lysine efflux transmembrane transporter activity
IXK98_RS18275	COG0076	glutamate decarboxylase activity
IXK98_RS18280	COG1737	Transcriptional regulator
IXK98_RS18285	COG1454	alcohol dehydrogenase
IXK98_RS18285	COG1012	belongs to the aldehyde dehydrogenase family
IXK98_RS18290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IXK98_RS18300	COG4160	amino acid transport
IXK98_RS18325	COG1882	Formate acetyltransferase
IXK98_RS18340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IXK98_RS18350	COG3013	Belongs to the UPF0304 family
IXK98_RS18365	COG2766	serine protein kinase
IXK98_RS18370	COG2718	Belongs to the UPF0229 family
IXK98_RS18375	COG2719	SpoVR family
IXK98_RS18380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IXK98_RS18385	COG2835	tetraacyldisaccharide 4'-kinase activity
IXK98_RS18395	COG1132	(ABC) transporter
IXK98_RS18400	COG0658	competence protein
IXK98_RS18400	COG2333	competence protein COMEC
IXK98_RS18425	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXK98_RS18430	COG1136	(ABC) transporter
IXK98_RS18435	COG4591	ABC-type transport system involved in lipoprotein release permease component
IXK98_RS18455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IXK98_RS18460	COG1252	NADH dehydrogenase
IXK98_RS18465	COG3150	esterase
IXK98_RS18490	COG0537	adenosine 5'-monophosphoramidase activity
IXK98_RS18505	COG2186	Transcriptional regulator
IXK98_RS18510	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IXK98_RS18520	COG1674	ftsk spoiiie
IXK98_RS18525	COG1522	sequence-specific DNA binding
IXK98_RS18530	COG0686	Belongs to the AlaDH PNT family
IXK98_RS18535	COG3092	negative regulation of chromosome organization
IXK98_RS18540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IXK98_RS18545	COG0280	phosphate acetyltransferase
IXK98_RS18545	COG0857	belongs to the CobB CobQ family
IXK98_RS18555	COG0435	Glutathione S-transferase
IXK98_RS18565	COG0444	Belongs to the ABC transporter superfamily
IXK98_RS18570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IXK98_RS18575	COG0601	transmembrane transport
IXK98_RS18590	COG2067	long-chain fatty acid transport protein
IXK98_RS18605	COG0577	efflux transmembrane transporter activity
IXK98_RS18605	COG1136	(ABC) transporter
IXK98_RS18610	COG1136	(ABC) transporter
IXK98_RS18610	COG0577	efflux transmembrane transporter activity
IXK98_RS18615	COG0577	efflux transmembrane transporter activity
IXK98_RS18625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXK98_RS18635	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXK98_RS18675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IXK98_RS18685	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IXK98_RS18710	COG2199	diguanylate cyclase activity
IXK98_RS18725	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IXK98_RS18730	COG1946	Acyl-CoA thioesterase
IXK98_RS18740	COG1522	sequence-specific DNA binding
IXK98_RS18745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IXK98_RS18765	COG0477	Major facilitator Superfamily
IXK98_RS18770	COG2855	membrane
IXK98_RS18785	COG1263	PTS System
IXK98_RS18785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS18785	COG2190	(PTS) system
IXK98_RS18805	COG0596	Alpha beta hydrolase
IXK98_RS18810	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IXK98_RS18815	COG1169	isochorismate synthase
IXK98_RS18820	COG0436	Aminotransferase
IXK98_RS18825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IXK98_RS18845	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IXK98_RS18850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IXK98_RS18865	COG0513	Belongs to the DEAD box helicase family
IXK98_RS18900	COG0616	signal peptide processing
IXK98_RS18905	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS18925	COG0784	Response regulator, receiver
IXK98_RS18925	COG0835	chemotaxis
IXK98_RS18930	COG1940	carbohydrate kinase activity
IXK98_RS18935	COG0469	pyruvate kinase activity
IXK98_RS18940	COG4667	esterase of the alpha-beta hydrolase superfamily
IXK98_RS18960	COG1263	PTS System
IXK98_RS18960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS18965	COG0084	hydrolase, TatD family'
IXK98_RS18970	COG0470	DNA polymerase III
IXK98_RS18980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IXK98_RS19010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IXK98_RS19020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IXK98_RS19025	COG1399	metal-binding, possibly nucleic acid-binding protein
IXK98_RS19030	COG0424	maF-like protein
IXK98_RS19035	COG0564	pseudouridine synthase activity
IXK98_RS19040	COG1530	ribonuclease E activity
IXK98_RS19045	COG0659	secondary active sulfate transmembrane transporter activity
IXK98_RS19050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IXK98_RS19055	COG0318	PFAM AMP-dependent synthetase and ligase
IXK98_RS19060	COG0596	Alpha beta hydrolase
IXK98_RS19065	COG3065	identical protein binding
IXK98_RS19075	COG1214	PFAM Peptidase M22, glycoprotease
IXK98_RS19080	COG1199	ATP-dependent helicase activity
IXK98_RS19090	COG0788	formyltetrahydrofolate deformylase activity
IXK98_RS19095	COG0446	pyridine nucleotide-disulphide oxidoreductase
IXK98_RS19095	COG1902	pentaerythritol trinitrate reductase activity
IXK98_RS19100	COG0616	signal peptide processing
IXK98_RS19115	COG0477	Major facilitator Superfamily
IXK98_RS19120	COG0252	asparaginase activity
IXK98_RS19130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IXK98_RS19135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IXK98_RS19145	COG0653	protein targeting
IXK98_RS19150	COG2165	general secretion pathway protein
IXK98_RS19155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IXK98_RS19160	COG2203	Gaf domain
IXK98_RS19160	COG2199	diguanylate cyclase activity
IXK98_RS19170	COG4120	Belongs to the binding-protein-dependent transport system permease family
IXK98_RS19185	COG0583	DNA-binding transcription factor activity
IXK98_RS19210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IXK98_RS19215	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IXK98_RS19225	COG0539	negative regulation of cytoplasmic translation
IXK98_RS19230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IXK98_RS19235	COG1555	photosystem II stabilization
IXK98_RS19240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IXK98_RS19245	COG0776	regulation of translation
IXK98_RS19250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IXK98_RS19265	COG0544	peptidyl-prolyl cis-trans isomerase activity
IXK98_RS19275	COG2204	response regulator
IXK98_RS19280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IXK98_RS19285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IXK98_RS19290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IXK98_RS19295	COG3842	ATPase activity
IXK98_RS19300	COG0395	ABC-type sugar transport system, permease component
IXK98_RS19305	COG1175	transmembrane transport
IXK98_RS19330	COG5002	protein histidine kinase activity
IXK98_RS19330	COG2205	protein histidine kinase activity
IXK98_RS19330	COG0784	Response regulator, receiver
IXK98_RS19335	COG0840	transmembrane signaling receptor activity
IXK98_RS19360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXK98_RS19370	COG2951	lytic endotransglycosylase activity
IXK98_RS19380	COG0850	regulation of cytokinetic process
IXK98_RS19385	COG2894	cell division
IXK98_RS19390	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IXK98_RS19400	COG1012	belongs to the aldehyde dehydrogenase family
IXK98_RS19400	COG1454	alcohol dehydrogenase
IXK98_RS19405	COG2095	MarC family integral membrane protein
IXK98_RS19410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXK98_RS19420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IXK98_RS19425	COG1757	Na H antiporter
IXK98_RS19465	COG0494	nUDIX hydrolase
IXK98_RS19470	COG0123	including yeast histone deacetylase and acetoin utilization protein
IXK98_RS19475	COG4580	involved in the transport of maltose and maltodextrins
IXK98_RS19480	COG1609	Transcriptional regulator
IXK98_RS19495	COG0395	ABC-type sugar transport system, permease component
IXK98_RS19500	COG2723	6-phospho-beta-galactosidase activity
IXK98_RS19505	COG3842	ATPase activity
IXK98_RS19510	COG1609	Transcriptional regulator
IXK98_RS19520	COG1881	PFAM PEBP family protein
IXK98_RS19535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IXK98_RS19540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IXK98_RS19560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IXK98_RS19570	COG0840	transmembrane signaling receptor activity
IXK98_RS19575	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IXK98_RS19590	COG0572	uridine kinase
IXK98_RS19595	COG0489	protein tyrosine kinase activity
IXK98_RS19630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IXK98_RS19630	COG0517	IMP dehydrogenase activity
IXK98_RS19630	COG0617	tRNA 3'-terminal CCA addition
IXK98_RS19640	COG3706	GGDEF domain
IXK98_RS19645	COG0314	molybdopterin synthase activity
IXK98_RS19650	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IXK98_RS19655	COG0315	cyclic pyranopterin monophosphate synthase activity
IXK98_RS19660	COG0521	Mo-molybdopterin cofactor biosynthetic process
IXK98_RS19665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IXK98_RS19670	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IXK98_RS19675	COG2198	Histidine kinase
IXK98_RS19680	COG2204	response regulator
IXK98_RS19685	COG0556	nucleotide-excision repair
IXK98_RS19720	COG3842	ATPase activity
IXK98_RS19730	COG4657	Part of a membrane complex involved in electron transport
IXK98_RS19740	COG4656	Part of a membrane complex involved in electron transport
IXK98_RS19745	COG4658	electron transport chain
IXK98_RS19750	COG4659	FMN binding
IXK98_RS19755	COG4660	Part of a membrane complex involved in electron transport
IXK98_RS19760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IXK98_RS19765	COG0346	lactoylglutathione lyase activity
IXK98_RS19785	COG2056	Na+-H+ antiporter family
IXK98_RS19790	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IXK98_RS19795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IXK98_RS19800	COG2716	regulation of RNA biosynthetic process
IXK98_RS19805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IXK98_RS19825	COG4783	chaperone-mediated protein folding
IXK98_RS19830	COG1393	Belongs to the ArsC family
IXK98_RS19850	COG2233	PERMEase
IXK98_RS19855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IXK98_RS19865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IXK98_RS19870	COG2912	Transglutaminase-like superfamily
IXK98_RS19880	COG2890	protein-(glutamine-N5) methyltransferase activity
IXK98_RS19890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IXK98_RS19895	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IXK98_RS19900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IXK98_RS19905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IXK98_RS20030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IXK98_RS20045	COG3951	Flagellar rod assembly protein muramidase FlgJ
IXK98_RS20045	COG1705	Flagellar rod assembly protein muramidase FlgJ
IXK98_RS20050	COG1706	bacterial-type flagellum-dependent cell motility
IXK98_RS20055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IXK98_RS20065	COG4787	bacterial-type flagellum-dependent cell motility
IXK98_RS20070	COG1749	Flagellar hook protein flgE
IXK98_RS20085	COG1815	bacterial-type flagellum-dependent cell motility
IXK98_RS20090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IXK98_RS20095	COG0784	Response regulator, receiver
IXK98_RS20095	COG0835	chemotaxis
IXK98_RS20105	COG2747	anti-sigma28 factor FlgM
IXK98_RS20145	COG2885	chlorophyll binding
IXK98_RS20165	COG2217	Heavy metal translocating P-type atpase
IXK98_RS20165	COG2608	mercury ion transmembrane transporter activity
IXK98_RS20190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IXK98_RS20200	COG0326	Molecular chaperone. Has ATPase activity
IXK98_RS20205	COG3710	Transcriptional regulator
IXK98_RS20225	COG0622	Phosphoesterase
IXK98_RS20250	COG1090	epimerase
IXK98_RS20255	COG0300	oxidoreductase activity
IXK98_RS20260	COG3118	belongs to the thioredoxin family
IXK98_RS20265	COG0330	HflC and HflK could
IXK98_RS20290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IXK98_RS20300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IXK98_RS20305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IXK98_RS20310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IXK98_RS20315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IXK98_RS20320	COG2190	(PTS) system
IXK98_RS20325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXK98_RS20330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IXK98_RS20335	COG1702	phosphate starvation-inducible protein PhoH
IXK98_RS20340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IXK98_RS20345	COG4535	Mg2 and Co2 transporter CorC
IXK98_RS20350	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IXK98_RS20355	COG2888	peptidyl-tyrosine sulfation
IXK98_RS20360	COG0495	leucyl-tRNA aminoacylation
IXK98_RS20365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IXK98_RS20370	COG1466	dna polymerase III delta subunit
IXK98_RS20375	COG0799	negative regulation of ribosome biogenesis
IXK98_RS20380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IXK98_RS20385	COG0768	penicillin binding
IXK98_RS20390	COG0772	Belongs to the SEDS family
IXK98_RS20395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXK98_RS20400	COG1686	Belongs to the peptidase S11 family
IXK98_RS20405	COG2921	Belongs to the UPF0250 family
IXK98_RS20425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXK98_RS20435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXK98_RS20465	COG0366	Alpha amylase catalytic
IXK98_RS20470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IXK98_RS20470	COG1263	PTS System
IXK98_RS20485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IXK98_RS20495	COG2011	ABC-type metal ion transport system permease component
IXK98_RS20500	COG1464	Belongs to the NlpA lipoprotein family
IXK98_RS20510	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IXK98_RS20520	COG0254	rRNA binding
IXK98_RS20525	COG1720	tRNA m6t6A37 methyltransferase activity
IXK98_RS20535	COG0121	glutamine amidotransferase
IXK98_RS20540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IXK98_RS20560	COG0328	RNA-DNA hybrid ribonuclease activity
IXK98_RS20565	COG2226	methyltransferase
IXK98_RS20570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IXK98_RS20575	COG1388	LysM domain
IXK98_RS20575	COG0741	lytic transglycosylase activity
IXK98_RS20585	COG3021	interspecies interaction between organisms
IXK98_RS20590	COG0347	Belongs to the P(II) protein family
IXK98_RS20610	COG0587	DNA-directed DNA polymerase activity
IXK98_RS20625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXK98_RS20635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IXK98_RS20640	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IXK98_RS20645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IXK98_RS20650	COG0750	zinc metalloprotease
IXK98_RS20655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IXK98_RS20660	COG0575	Belongs to the CDS family
IXK98_RS20665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IXK98_RS20670	COG0233	cytoplasmic translational termination
IXK98_RS20685	COG0052	Belongs to the universal ribosomal protein uS2 family
IXK98_RS20690	COG0024	Methionine aminopeptidase
IXK98_RS20705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IXK98_RS20715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IXK98_RS20735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXK98_RS20735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IXK98_RS20740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IXK98_RS20745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IXK98_RS20750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IXK98_RS20760	COG1073	alpha beta
IXK98_RS20770	COG2252	PERMEase
IXK98_RS20775	COG2195	Cleaves the N-terminal amino acid of tripeptides
IXK98_RS20780	COG4067	protein conserved in archaea
IXK98_RS20780	COG0189	ligase activity
IXK98_RS20785	COG0189	ligase activity
IXK98_RS20795	COG0733	neurotransmitter:sodium symporter activity
IXK98_RS20800	COG4251	negative regulation of phosphorylation
IXK98_RS20800	COG3706	GGDEF domain
IXK98_RS20800	COG2203	Gaf domain
IXK98_RS20800	COG5001	Diguanylate cyclase
IXK98_RS20815	COG0514	ATP-dependent DNA helicase (RecQ)
IXK98_RS20820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IXK98_RS20830	COG2991	Protein conserved in bacteria
IXK98_RS20835	COG1477	protein flavinylation
IXK98_RS20840	COG2871	sodium ion transport
IXK98_RS20845	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IXK98_RS20850	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IXK98_RS20860	COG1805	sodium ion transport
IXK98_RS20865	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IXK98_RS20870	COG0271	Belongs to the BolA IbaG family
IXK98_RS20890	COG2211	Major facilitator Superfamily
IXK98_RS20900	COG1595	DNA-templated transcription, initiation
IXK98_RS20915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IXK98_RS20920	COG0693	protein deglycase activity
IXK98_RS20925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IXK98_RS20930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IXK98_RS20940	COG0560	Phosphoserine phosphatase
IXK98_RS20950	COG0813	purine-nucleoside phosphorylase activity
IXK98_RS20955	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IXK98_RS20960	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IXK98_RS20975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IXK98_RS20980	COG0084	hydrolase, TatD family'
IXK98_RS20990	COG3022	response to hydroperoxide
IXK98_RS20995	COG1115	amino acid carrier protein
IXK98_RS21010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IXK98_RS21020	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IXK98_RS21025	COG0583	DNA-binding transcription factor activity
IXK98_RS21030	COG0730	response to heat
IXK98_RS21035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IXK98_RS21040	COG0505	Belongs to the CarA family
IXK98_RS21050	COG0494	nUDIX hydrolase
IXK98_RS21065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IXK98_RS21070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IXK98_RS21075	COG0849	cell division
IXK98_RS21080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IXK98_RS21085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXK98_RS21090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IXK98_RS21095	COG0772	Belongs to the SEDS family
IXK98_RS21100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IXK98_RS21110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IXK98_RS21120	COG0768	penicillin binding
IXK98_RS21125	COG3116	cell division
IXK98_RS21140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IXK98_RS21145	COG3107	peptidoglycan biosynthetic process
IXK98_RS21155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IXK98_RS21165	COG2969	positive regulation of protein catabolic process
IXK98_RS21170	COG0625	glutathione transferase activity
IXK98_RS21175	COG2857	Cytochrome c1
IXK98_RS21180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IXK98_RS21185	COG0723	plastoquinol--plastocyanin reductase activity
IXK98_RS21200	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IXK98_RS21205	COG3105	Protein conserved in bacteria
IXK98_RS21210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXK98_RS21215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IXK98_RS21230	COG3150	esterase
IXK98_RS21240	COG3151	Protein conserved in bacteria
IXK98_RS21245	COG0494	nUDIX hydrolase
IXK98_RS21250	COG1538	Outer membrane efflux protein
IXK98_RS21260	COG2198	Histidine kinase
IXK98_RS21260	COG5002	protein histidine kinase activity
IXK98_RS21260	COG0784	Response regulator, receiver
IXK98_RS21265	COG5001	Diguanylate cyclase
IXK98_RS21265	COG2203	Gaf domain
IXK98_RS21265	COG3706	GGDEF domain
IXK98_RS21265	COG4251	negative regulation of phosphorylation
IXK98_RS21270	COG1242	4 iron, 4 sulfur cluster binding
IXK98_RS21275	COG0067	glutamate synthase
IXK98_RS21275	COG0069	glutamate synthase activity
IXK98_RS21275	COG0070	glutamate synthase
IXK98_RS21285	COG0069	glutamate synthase activity
IXK98_RS21285	COG0070	glutamate synthase
IXK98_RS21285	COG0067	glutamate synthase
IXK98_RS21290	COG0493	'glutamate synthase
IXK98_RS21315	COG0195	Participates in both transcription termination and antitermination
IXK98_RS21320	COG0779	Required for maturation of 30S ribosomal subunits
IXK98_RS21335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXK98_RS21340	COG3153	acetyltransferase
IXK98_RS21345	COG3154	lipid carrier protein
IXK98_RS21355	COG0826	peptidase U32
IXK98_RS21360	COG0826	peptidase U32
IXK98_RS21385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IXK98_RS21390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IXK98_RS21400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IXK98_RS21405	COG2860	membrane
IXK98_RS21410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IXK98_RS21415	COG0083	homoserine kinase activity
IXK98_RS21430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXK98_RS21440	COG0745	RESPONSE REGULATOR receiver
IXK98_RS21445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IXK98_RS21445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IXK98_RS21450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IXK98_RS21460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IXK98_RS21465	COG3025	triphosphatase activity
IXK98_RS21470	COG1392	Phosphate transport regulator
IXK98_RS21475	COG0306	phosphate transporter
IXK98_RS21480	COG4991	sh3 domain protein
IXK98_RS21490	COG3409	Peptidoglycan-binding domain 1 protein
IXK98_RS21490	COG3267	Type II secretory pathway component ExeA
IXK98_RS21500	COG0148	phosphopyruvate hydratase activity
IXK98_RS21510	COG3956	TIGRFAM MazG family protein
IXK98_RS21515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IXK98_RS21520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IXK98_RS21525	COG3437	response regulator, receiver
IXK98_RS21525	COG2205	protein histidine kinase activity
IXK98_RS21525	COG4999	Histidine kinase
IXK98_RS21525	COG3850	Histidine kinase
IXK98_RS21545	COG0736	holo-[acyl-carrier-protein] synthase activity
IXK98_RS21550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IXK98_RS21555	COG1381	Involved in DNA repair and RecF pathway recombination
IXK98_RS21560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IXK98_RS21580	COG3086	response to oxidative stress
IXK98_RS21585	COG3026	antisigma factor binding
IXK98_RS21595	COG1595	DNA-templated transcription, initiation
IXK98_RS21600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IXK98_RS21610	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IXK98_RS21630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXK98_RS21635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IXK98_RS21640	COG3079	Belongs to the UPF0149 family
IXK98_RS21645	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IXK98_RS21655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IXK98_RS21660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IXK98_RS21665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IXK98_RS21675	COG0028	Belongs to the TPP enzyme family
IXK98_RS21680	COG1022	Amp-dependent synthetase and ligase
IXK98_RS21685	COG0583	DNA-binding transcription factor activity
IXK98_RS21700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IXK98_RS21705	COG0473	3-isopropylmalate dehydrogenase activity
IXK98_RS21770	COG3437	response regulator, receiver
IXK98_RS21830	COG0582	viral genome integration into host DNA
IXK98_RS21845	COG1854	S-ribosylhomocysteine lyase activity
IXK98_RS21855	COG2918	glutathione biosynthetic process
IXK98_RS21860	COG0612	Peptidase, M16
IXK98_RS21865	COG1238	metal cluster binding
IXK98_RS21875	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IXK98_RS21880	COG5016	pyruvate
IXK98_RS21880	COG0511	ligase activity, forming carbon-carbon bonds
IXK98_RS21885	COG3630	sodium ion export across plasma membrane
IXK98_RS21935	COG0527	aspartate kinase activity
IXK98_RS21950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IXK98_RS21955	COG1546	Belongs to the CinA family
IXK98_RS21960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IXK98_RS21965	COG0795	lipopolysaccharide-transporting ATPase activity
IXK98_RS21970	COG0795	lipopolysaccharide-transporting ATPase activity
IXK98_RS21980	COG2927	DNA polymerase III (CHI subunit)
IXK98_RS21985	COG0525	valine-tRNA ligase activity
IXK98_RS21995	COG4269	membrane
IXK98_RS22005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IXK98_RS22010	COG0564	pseudouridine synthase activity
IXK98_RS22015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IXK98_RS22020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IXK98_RS22035	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IXK98_RS22040	COG0251	oxidation-reduction process
IXK98_RS22050	COG0039	L-malate dehydrogenase activity
IXK98_RS22055	COG1438	arginine binding
IXK98_RS22060	COG2358	TRAP transporter, solute receptor (TAXI family
IXK98_RS22070	COG0589	response to stress
IXK98_RS22090	COG2235	arginine
IXK98_RS22095	COG0312	modulator of DNA gyrase
IXK98_RS22100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IXK98_RS22105	COG3164	Protein of unknown function
IXK98_RS22115	COG0424	maF-like protein
IXK98_RS22120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IXK98_RS22125	COG1792	Involved in formation and maintenance of cell shape
IXK98_RS22130	COG1077	Cell shape determining protein MreB Mrl
IXK98_RS22160	COG2165	general secretion pathway protein
IXK98_RS22165	COG2165	general secretion pathway protein
IXK98_RS22175	COG1459	type II secretion system
IXK98_RS22180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IXK98_RS22190	COG3267	Type II secretory pathway component ExeA
IXK98_RS22190	COG3409	Peptidoglycan-binding domain 1 protein
IXK98_RS22215	COG2200	EAL domain
IXK98_RS22215	COG2199	diguanylate cyclase activity
IXK98_RS22220	COG0629	single-stranded DNA binding
IXK98_RS22225	COG2197	response regulator
IXK98_RS22235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IXK98_RS22245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IXK98_RS22250	COG0527	aspartate kinase activity
IXK98_RS22255	COG0312	modulator of DNA gyrase
IXK98_RS22260	COG3028	Belongs to the UPF0307 family
IXK98_RS22265	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IXK98_RS22270	COG1178	ABC-type Fe3 transport system permease component
IXK98_RS22275	COG4143	(ABC) transporter
IXK98_RS22280	COG0163	prenyltransferase activity
IXK98_RS22285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IXK98_RS22300	COG2105	PFAM AIG2 family protein
IXK98_RS22305	COG2911	Protein conserved in bacteria
IXK98_RS22310	COG0729	surface antigen
IXK98_RS22315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IXK98_RS22320	COG4566	intracellular signal transduction
IXK98_RS22320	COG0745	RESPONSE REGULATOR receiver
IXK98_RS22325	COG0004	ammonium transporteR
IXK98_RS22335	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IXK98_RS22350	COG1136	(ABC) transporter
IXK98_RS22375	COG0432	Pfam Uncharacterised protein family UPF0047
IXK98_RS22390	COG0251	oxidation-reduction process
IXK98_RS22400	COG2964	Protein conserved in bacteria
IXK98_RS22410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IXK98_RS22435	COG2965	DNA replication, synthesis of RNA primer
IXK98_RS22440	COG0360	Binds together with S18 to 16S ribosomal RNA
IXK98_RS22445	COG2194	sulfuric ester hydrolase activity
IXK98_RS22450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXK98_RS22460	COG2906	2 iron, 2 sulfur cluster binding
IXK98_RS22470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IXK98_RS22485	COG2168	tRNA wobble position uridine thiolation
IXK98_RS22490	COG2923	Belongs to the DsrF TusC family
IXK98_RS22495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IXK98_RS22500	COG2964	Protein conserved in bacteria
IXK98_RS22505	COG0545	Peptidyl-prolyl cis-trans isomerase
IXK98_RS22515	COG2900	Belongs to the SlyX family
IXK98_RS22525	COG0330	HflC and HflK could
IXK98_RS22530	COG0330	HflC and HflK could
IXK98_RS22535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IXK98_RS22545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IXK98_RS22550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IXK98_RS22560	COG0802	atpase or kinase
IXK98_RS22565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IXK98_RS22625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IXK98_RS22630	COG1162	GTPase activity
IXK98_RS22640	COG0490	domain, Protein
IXK98_RS22640	COG0471	metal ion transport
IXK98_RS22645	COG0840	transmembrane signaling receptor activity
IXK98_RS22685	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IXK98_RS22695	COG0085	RNA polymerase activity
IXK98_RS22705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IXK98_RS22720	COG0250	Participates in transcription elongation, termination and antitermination
IXK98_RS22725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IXK98_RS22755	COG1072	(Pantothenic acid kinase))
IXK98_RS22770	COG0149	triose-phosphate isomerase activity
IXK98_RS22775	COG0534	Mate efflux family protein
IXK98_RS22780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IXK98_RS22785	COG1575	Belongs to the MenA family. Type 1 subfamily
IXK98_RS22790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IXK98_RS22795	COG1509	lysine 2,3-aminomutase activity
IXK98_RS22805	COG1285	pathogenesis
IXK98_RS22810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IXK98_RS22820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IXK98_RS22825	COG3678	ATP-independent chaperone mediated protein folding
IXK98_RS22830	COG0745	RESPONSE REGULATOR receiver
IXK98_RS22835	COG2205	protein histidine kinase activity
IXK98_RS22840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IXK98_RS22845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IXK98_RS22850	COG0180	Tryptophanyl-tRNA synthetase
IXK98_RS22855	COG0546	phosphoglycolate phosphatase activity
IXK98_RS22860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IXK98_RS22865	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IXK98_RS22875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IXK98_RS22910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IXK98_RS22920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IXK98_RS22920	COG0678	peroxiredoxin activity
IXK98_RS22925	COG0251	oxidation-reduction process
IXK98_RS22935	COG0165	Argininosuccinate lyase
IXK98_RS22935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IXK98_RS22940	COG0137	argininosuccinate synthase activity
IXK98_RS22945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IXK98_RS22950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IXK98_RS22955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXK98_RS22960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IXK98_RS22965	COG1695	Transcriptional regulator
IXK98_RS22970	COG1045	serine acetyltransferase
IXK98_RS22985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXK98_RS22990	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IXK98_RS22995	COG1053	succinate dehydrogenase
IXK98_RS23000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IXK98_RS23015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IXK98_RS23025	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IXK98_RS23030	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IXK98_RS23035	COG1609	Transcriptional regulator
IXK98_RS23040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IXK98_RS23045	COG0254	rRNA binding
IXK98_RS23050	COG0281	malic enzyme
IXK98_RS23055	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IXK98_RS23060	COG0626	cystathionine gamma-synthase activity
IXK98_RS23065	COG0460	homoserine dehydrogenase
IXK98_RS23065	COG0527	aspartate kinase activity
IXK98_RS23070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IXK98_RS23075	COG3074	FtsZ-dependent cytokinesis
IXK98_RS23080	COG1494	fructose-1,6-bisphosphatase
IXK98_RS23150	COG4206	TonB-dependent receptor
IXK98_RS23170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXK98_RS23180	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IXK98_RS23185	COG0534	Mate efflux family protein
IXK98_RS23200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IXK98_RS23205	COG2937	Belongs to the GPAT DAPAT family
IXK98_RS23210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IXK98_RS23215	COG3161	chorismate lyase activity
IXK98_RS23220	COG1580	Controls the rotational direction of flagella during chemotaxis
IXK98_RS23225	COG0705	Rhomboid family
IXK98_RS23230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IXK98_RS23240	COG2177	Part of the ABC transporter FtsEX involved in
IXK98_RS23245	COG2884	Cell division ATP-binding protein ftsE
IXK98_RS23250	COG0552	protein localization to endoplasmic reticulum
IXK98_RS23250	COG0552	protein localization to endoplasmic reticulum
IXK98_RS23255	COG0742	ribosomal rna small subunit methyltransferase
IXK98_RS23265	COG2095	MarC family integral membrane protein
IXK98_RS23305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IXK98_RS23310	COG0640	Transcriptional regulator
IXK98_RS23315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IXK98_RS23320	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS23325	COG2267	carboxylic ester hydrolase activity
IXK98_RS23330	COG0561	phosphatase activity
IXK98_RS23345	COG3148	PFAM DTW domain containing protein
IXK98_RS23350	COG2200	EAL domain
IXK98_RS23350	COG2199	diguanylate cyclase activity
IXK98_RS23350	COG3287	FIST C domain
IXK98_RS23355	COG1011	Hydrolase
IXK98_RS23360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IXK98_RS23370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IXK98_RS23375	COG0019	diaminopimelate decarboxylase activity
IXK98_RS23385	COG1965	Belongs to the frataxin family
IXK98_RS23390	COG3072	Adenylate cyclase
IXK98_RS23400	COG1587	Uroporphyrinogen-III synthase
IXK98_RS23405	COG2959	enzyme of heme biosynthesis
IXK98_RS23410	COG3071	HemY protein
IXK98_RS23485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IXK98_RS23500	COG3118	belongs to the thioredoxin family
IXK98_RS23510	COG0248	Ppx GppA phosphatase
IXK98_RS23515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IXK98_RS23525	COG0514	ATP-dependent DNA helicase (RecQ)
IXK98_RS23530	COG2962	Rard protein
IXK98_RS23540	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS23545	COG0405	Gamma-glutamyltransferase
IXK98_RS23555	COG0210	DNA helicase
IXK98_RS23565	COG3220	belongs to the UPF0276 family
IXK98_RS23590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IXK98_RS23600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IXK98_RS23635	COG1061	Type III restriction enzyme res subunit
IXK98_RS23675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IXK98_RS23680	COG0601	transmembrane transport
IXK98_RS23685	COG0747	negative chemotaxis
IXK98_RS23730	COG1309	transcriptional regulator
IXK98_RS23735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IXK98_RS23740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IXK98_RS23745	COG2960	long-chain fatty acid transporting porin activity
IXK98_RS23750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IXK98_RS23755	COG0583	DNA-binding transcription factor activity
IXK98_RS23785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IXK98_RS23790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXK98_RS23790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IXK98_RS23805	COG0084	hydrolase, TatD family'
IXK98_RS23810	COG0805	protein transport
IXK98_RS23815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXK98_RS23820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IXK98_RS23835	COG2226	methyltransferase
IXK98_RS23840	COG1322	Protein conserved in bacteria
IXK98_RS23850	COG1639	'signal transduction protein
IXK98_RS23865	COG2081	HI0933 family
IXK98_RS23875	COG1528	Iron-storage protein
IXK98_RS23880	COG0589	response to stress
IXK98_RS23895	COG0742	ribosomal rna small subunit methyltransferase
IXK98_RS23900	COG5001	Diguanylate cyclase
IXK98_RS23900	COG5002	protein histidine kinase activity
IXK98_RS23905	COG1522	sequence-specific DNA binding
IXK98_RS23925	COG0006	proline dipeptidase activity
IXK98_RS23925	COG0006	proline dipeptidase activity
IXK98_RS23940	COG2104	thiamine diphosphate biosynthetic process
IXK98_RS23945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IXK98_RS23960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IXK98_RS23965	COG2132	Multicopper oxidase
IXK98_RS24040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IXK98_RS24050	COG0346	lactoylglutathione lyase activity
IXK98_RS24090	COG0175	sulfate reduction
IXK98_RS24095	COG2895	sulfate adenylyltransferase (ATP) activity
IXK98_RS24100	COG0471	metal ion transport
IXK98_RS24100	COG0490	domain, Protein
IXK98_RS24105	COG0529	Catalyzes the synthesis of activated sulfate
IXK98_RS24130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IXK98_RS24140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IXK98_RS24225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IXK98_RS24280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IXK98_RS24285	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS24295	COG1280	lysine exporter protein (LysE YggA)
IXK98_RS24315	COG4974	Belongs to the 'phage' integrase family
IXK98_RS24330	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IXK98_RS24350	COG3710	Transcriptional regulator
IXK98_RS24420	COG1716	ATPase activity
IXK98_RS24440	COG1181	Belongs to the D-alanine--D-alanine ligase family
IXK98_RS24505	COG0814	amino acid
IXK98_RS24520	COG4166	transmembrane transport
IXK98_RS24525	COG1881	PFAM PEBP family protein
IXK98_RS24530	COG1902	pentaerythritol trinitrate reductase activity
IXK98_RS24540	COG1028	Short-chain dehydrogenase reductase Sdr
IXK98_RS24575	COG2814	Major facilitator Superfamily
IXK98_RS24585	COG1192	Involved in chromosome partitioning
IXK98_RS24620	COG0745	RESPONSE REGULATOR receiver
IXK98_RS24630	COG0784	Response regulator, receiver
IXK98_RS24630	COG5002	protein histidine kinase activity
IXK98_RS24630	COG2205	protein histidine kinase activity
IXK98_RS24640	COG0527	aspartate kinase activity
IXK98_RS24645	COG3706	GGDEF domain
IXK98_RS24645	COG2203	Gaf domain
IXK98_RS24645	COG5001	Diguanylate cyclase
IXK98_RS24645	COG4251	negative regulation of phosphorylation
IXK98_RS24650	COG0189	ligase activity
IXK98_RS24660	COG4067	protein conserved in archaea
IXK98_RS24660	COG0189	ligase activity
IXK98_RS24665	COG2239	Acts as a magnesium transporter
IXK98_RS24695	COG0840	transmembrane signaling receptor activity
IXK98_RS24720	COG2423	ornithine cyclodeaminase activity
IXK98_RS24745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IXK98_RS24755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IXK98_RS24765	COG1714	RDD family
IXK98_RS24770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IXK98_RS24770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IXK98_RS24840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IXK98_RS24845	COG0732	type I restriction modification DNA specificity domain
IXK98_RS24855	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IXK98_RS24885	COG1742	UPF0060 membrane protein
IXK98_RS24940	COG2003	Belongs to the UPF0758 family
IXK98_RS24955	COG1917	Cupin 2, conserved barrel domain protein
IXK98_RS24955	COG4977	sequence-specific DNA binding
IXK98_RS25000	COG3710	Transcriptional regulator
IXK98_RS25015	COG0583	DNA-binding transcription factor activity
IXK98_RS25030	COG4452	Inner membrane protein CreD
IXK98_RS25035	COG2205	protein histidine kinase activity
IXK98_RS25040	COG0745	RESPONSE REGULATOR receiver
IXK98_RS25085	COG1522	sequence-specific DNA binding
IXK98_RS25100	COG1132	(ABC) transporter
IXK98_RS25115	COG0840	transmembrane signaling receptor activity
IXK98_RS25135	COG1309	transcriptional regulator
IXK98_RS25145	COG0583	DNA-binding transcription factor activity
IXK98_RS25160	COG0697	spore germination
IXK98_RS25165	COG0583	DNA-binding transcription factor activity
IXK98_RS25170	COG4974	Belongs to the 'phage' integrase family
IXK98_RS25180	COG3457	Alanine racemase
IXK98_RS25200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IXK98_RS25205	COG0459	protein refolding
IXK98_RS25210	COG0071	Belongs to the small heat shock protein (HSP20) family
IXK98_RS25215	COG0071	Belongs to the small heat shock protein (HSP20) family
IXK98_RS25225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IXK98_RS25230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IXK98_RS25235	COG1882	Formate acetyltransferase
IXK98_RS25240	COG1349	DNA-binding transcription factor activity
IXK98_RS25260	COG1733	regulation of RNA biosynthetic process
IXK98_RS25280	COG5507	3-demethylubiquinone-9 3-methyltransferase
IXK98_RS25285	COG1609	Transcriptional regulator
IXK98_RS25300	COG2814	Major facilitator Superfamily
IXK98_RS25310	COG1760	l-serine dehydratase
IXK98_RS25325	COG1566	PFAM secretion protein HlyD family protein
IXK98_RS25340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IXK98_RS25350	COG0251	oxidation-reduction process
IXK98_RS25355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IXK98_RS25365	COG0673	inositol 2-dehydrogenase activity
IXK98_RS25405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IXK98_RS25415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IXK98_RS25550	COG0793	Belongs to the peptidase S41A family
IXK98_RS25550	COG4946	Tricorn protease homolog
IXK98_RS25585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IXK98_RS25625	COG0653	protein targeting
IXK98_RS25700	COG2026	Addiction module toxin, RelE StbE family