locus-tag	class	description
VF_0001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VF_0002	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VF_0003	COG0706	membrane insertase activity
VF_0004	COG0594	ribonuclease P activity
VF_0006	COG1126	abc transporter atp-binding protein
VF_0009	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VF_0010	COG0592	DNA-directed DNA polymerase activity
VF_0011	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VF_0012	COG0187	DNA topoisomerase II activity
VF_0013	COG0071	Belongs to the small heat shock protein (HSP20) family
VF_0014	COG3977	Valine--pyruvate aminotransferase
VF_0016	COG0751	glycine-tRNA ligase activity
VF_0017	COG0366	Alpha amylase catalytic
VF_0021	COG0583	DNA-binding transcription factor activity
VF_0022	COG4682	membrane
VF_0023	COG0604	alcohol dehydrogenase
VF_0024	COG0183	Belongs to the thiolase family
VF_0025	COG1250	3-hydroxyacyl-CoA dehydrogenase
VF_0025	COG1024	Enoyl-CoA hydratase
VF_0026	COG1739	Uncharacterized protein family UPF0029
VF_0027	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VF_0029	COG0612	Peptidase, M16
VF_0031	COG0038	chloride channel
VF_0032	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VF_0033	COG0352	thiamine-phosphate diphosphorylase activity
VF_0034	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VF_0035	COG2022	thiamine diphosphate biosynthetic process
VF_0037	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VF_0038	COG0006	proline dipeptidase activity
VF_0038	COG0006	proline dipeptidase activity
VF_0044	COG1322	Protein conserved in bacteria
VF_0046	COG2226	methyltransferase
VF_0048	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VF_0049	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VF_0050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VF_0051	COG0805	protein transport
VF_0052	COG0084	hydrolase, TatD family'
VF_0054	COG0248	Ppx GppA phosphatase
VF_0056	COG0513	Belongs to the DEAD box helicase family
VF_0057	COG3118	belongs to the thioredoxin family
VF_0060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VF_0063	COG3071	HemY protein
VF_0064	COG2959	enzyme of heme biosynthesis
VF_0065	COG1587	Uroporphyrinogen-III synthase
VF_0068	COG0210	DNA helicase
VF_0069	COG2962	Rard protein
VF_0070	COG0514	ATP-dependent DNA helicase (RecQ)
VF_0072	COG2271	Major facilitator Superfamily
VF_0073	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VF_0074	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VF_0074	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VF_0075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VF_0078	COG3078	GTPase activator activity
VF_0081	COG1522	sequence-specific DNA binding
VF_0082	COG0742	ribosomal rna small subunit methyltransferase
VF_0083	COG0589	response to stress
VF_0084	COG1528	Iron-storage protein
VF_0086	COG2081	HI0933 family
VF_0087	COG2199	diguanylate cyclase activity
VF_0087	COG3287	FIST C domain
VF_0087	COG2200	EAL domain
VF_0088	COG3148	PFAM DTW domain containing protein
VF_0090	COG0800	Aldolase
VF_0091	COG5001	Diguanylate cyclase
VF_0093	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VF_0094	COG4251	negative regulation of phosphorylation
VF_0094	COG5001	Diguanylate cyclase
VF_0094	COG3706	GGDEF domain
VF_0094	COG2203	Gaf domain
VF_0096	COG3852	Histidine kinase
VF_0098	COG0174	glutamine synthetase
VF_0099	COG1217	gtp-binding protein TYPA
VF_0100	COG1295	ribonuclease BN
VF_0102	COG0456	acetyltransferase
VF_0103	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VF_0104	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VF_0106	COG0194	GDP metabolic process
VF_0110	COG1561	YicC-like family, N-terminal region
VF_0111	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VF_0116	COG2233	PERMEase
VF_0117	COG1040	competence protein
VF_0118	COG2267	carboxylic ester hydrolase activity
VF_0120	COG2183	response to ionizing radiation
VF_0121	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VF_0122	COG1560	Kdo2-lipid A biosynthetic process
VF_0125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VF_0126	COG2003	Belongs to the UPF0758 family
VF_0130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VF_0131	COG1368	sulfuric ester hydrolase activity
VF_0132	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VF_0133	COG0438	transferase activity, transferring glycosyl groups
VF_0134	COG0463	Glycosyl transferase, family 2
VF_0135	COG0859	PFAM glycosyl transferase family 9
VF_0136	COG3642	lipopolysaccharide core region biosynthetic process
VF_0137	COG3083	sulfuric ester hydrolase activity
VF_0138	COG1519	Transferase
VF_0139	COG0859	PFAM glycosyl transferase family 9
VF_0141	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VF_0142	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VF_0143	COG2089	acid synthase
VF_0147	COG1083	cytidylyl-transferase
VF_0148	COG1028	Short-chain dehydrogenase reductase Sdr
VF_0149	COG0438	transferase activity, transferring glycosyl groups
VF_0152	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VF_0153	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VF_0157	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VF_0162	COG1596	polysaccharide export
VF_0164	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VF_0166	COG1088	dTDP-glucose 4,6-dehydratase activity
VF_0170	COG2244	polysaccharide biosynthetic process
VF_0175	COG1216	Glycosyl transferase, family 2
VF_0176	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VF_0177	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VF_0179	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VF_0179	COG0517	IMP dehydrogenase activity
VF_0180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VF_0182	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VF_0191	COG1086	Polysaccharide biosynthesis protein
VF_0196	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VF_0201	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VF_0202	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VF_0203	COG0534	Mate efflux family protein
VF_0209	COG1494	fructose-1,6-bisphosphatase
VF_0210	COG3074	FtsZ-dependent cytokinesis
VF_0211	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VF_0212	COG1575	Belongs to the MenA family. Type 1 subfamily
VF_0214	COG3954	Phosphoribulokinase
VF_0216	COG0429	hydrolase of the alpha beta-hydrolase fold
VF_0218	COG0488	(ABC) transporter
VF_0219	COG2249	NAD(P)H dehydrogenase (quinone) activity
VF_0223	COG1047	Peptidyl-prolyl cis-trans
VF_0226	COG0545	Peptidyl-prolyl cis-trans isomerase
VF_0227	COG2964	Protein conserved in bacteria
VF_0228	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VF_0229	COG2923	Belongs to the DsrF TusC family
VF_0232	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VF_0245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VF_0249	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VF_0250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VF_0251	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VF_0252	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VF_0253	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VF_0257	COG0201	protein transport
VF_0259	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VF_0264	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VF_0265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VF_0266	COG0163	prenyltransferase activity
VF_0267	COG4143	(ABC) transporter
VF_0268	COG1178	ABC-type Fe3 transport system permease component
VF_0269	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VF_0270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VF_0271	COG0564	pseudouridine synthase activity
VF_0272	COG0589	response to stress
VF_0275	COG1438	arginine binding
VF_0276	COG0039	L-malate dehydrogenase activity
VF_0277	COG0142	geranyltranstransferase activity
VF_0280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VF_0281	COG2966	Psort location CytoplasmicMembrane, score
VF_0285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VF_0287	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VF_0288	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VF_0289	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VF_0290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VF_0292	COG0066	3-isopropylmalate dehydratase activity
VF_0293	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VF_0294	COG0473	3-isopropylmalate dehydrogenase activity
VF_0295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VF_0301	COG0305	Participates in initiation and elongation during chromosome replication
VF_0302	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VF_0306	COG0735	belongs to the Fur family
VF_0310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VF_0311	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VF_0312	COG0175	sulfate reduction
VF_0314	COG0545	Peptidyl-prolyl cis-trans isomerase
VF_0315	COG3061	Opacity-associated protein A
VF_0315	COG3266	domain, Protein
VF_0317	COG2153	protein acetylation
VF_0319	COG0737	Belongs to the 5'-nucleotidase family
VF_0321	COG2895	sulfate adenylyltransferase (ATP) activity
VF_0322	COG3273	potassium ion transport
VF_0322	COG0471	metal ion transport
VF_0323	COG0529	Catalyzes the synthesis of activated sulfate
VF_0326	COG0577	efflux transmembrane transporter activity
VF_0329	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VF_0331	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VF_0337	COG0646	methionine synthase
VF_0337	COG1410	methionine synthase
VF_0338	COG0527	aspartate kinase activity
VF_0339	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VF_0341	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VF_0344	COG0297	glycogen (starch) synthase activity
VF_0344	COG0438	transferase activity, transferring glycosyl groups
VF_0345	COG0438	transferase activity, transferring glycosyl groups
VF_0350	COG1596	polysaccharide export
VF_0352	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VF_0353	COG0629	single-stranded DNA binding
VF_0355	COG2200	EAL domain
VF_0355	COG2199	diguanylate cyclase activity
VF_0360	COG3267	Type II secretory pathway component ExeA
VF_0360	COG3409	Peptidoglycan-binding domain 1 protein
VF_0362	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VF_0363	COG1459	type II secretion system
VF_0365	COG2165	general secretion pathway protein
VF_0372	COG1077	Cell shape determining protein MreB Mrl
VF_0373	COG1792	Involved in formation and maintenance of cell shape
VF_0374	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VF_0375	COG0424	maF-like protein
VF_0376	COG1530	ribonuclease E activity
VF_0377	COG3164	Protein of unknown function
VF_0378	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VF_0379	COG0312	modulator of DNA gyrase
VF_0381	COG0312	modulator of DNA gyrase
VF_0382	COG2239	Acts as a magnesium transporter
VF_0383	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VF_0388	COG1137	ATPase activity
VF_0389	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VF_0391	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VF_0392	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VF_0392	COG0517	IMP dehydrogenase activity
VF_0394	COG1127	ABC transporter
VF_0395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VF_0396	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VF_0397	COG2854	intermembrane phospholipid transfer
VF_0400	COG5007	Belongs to the BolA IbaG family
VF_0401	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VF_0402	COG0204	Acyl-transferase
VF_0403	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
VF_0404	COG0251	oxidation-reduction process
VF_0406	COG0540	Belongs to the ATCase OTCase family
VF_0407	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VF_0408	COG2235	arginine
VF_0411	COG0525	valine-tRNA ligase activity
VF_0412	COG2927	DNA polymerase III (CHI subunit)
VF_0413	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VF_0414	COG0795	lipopolysaccharide-transporting ATPase activity
VF_0415	COG0795	lipopolysaccharide-transporting ATPase activity
VF_0418	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VF_0420	COG0741	lytic transglycosylase activity
VF_0422	COG1194	a g-specific adenine glycosylase
VF_0423	COG2066	Belongs to the glutaminase family
VF_0424	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VF_0425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VF_0427	COG1872	DUF167
VF_0428	COG0762	integral membrane protein
VF_0429	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VF_0430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VF_0433	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VF_0435	COG0189	ligase activity
VF_0436	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VF_0437	COG2356	endonuclease I
VF_0438	COG3091	SprT-like family
VF_0440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VF_0441	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VF_0442	COG0126	phosphoglycerate kinase activity
VF_0443	COG0191	fructose-bisphosphate aldolase activity
VF_0444	COG0513	Belongs to the DEAD box helicase family
VF_0445	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VF_0447	COG0716	FMN binding
VF_0448	COG4974	Belongs to the 'phage' integrase family
VF_0449	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VF_0450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VF_0453	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VF_0454	COG2204	response regulator
VF_0455	COG3066	DNA modification
VF_0458	COG0730	response to heat
VF_0459	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VF_0460	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VF_0461	COG1283	sodium-dependent phosphate transmembrane transporter activity
VF_0462	COG0583	DNA-binding transcription factor activity
VF_0463	COG0640	Transcriptional regulator
VF_0465	COG0728	peptidoglycan biosynthetic process
VF_0466	COG0196	riboflavin kinase activity
VF_0467	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VF_0468	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VF_0469	COG1047	Peptidyl-prolyl cis-trans
VF_0470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VF_0472	COG0505	Belongs to the CarA family
VF_0473	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VF_0474	COG2027	D-alanyl-D-alanine carboxypeptidase
VF_0475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VF_0476	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VF_0477	COG1534	Rna-binding protein
VF_0478	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VF_0479	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VF_0480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VF_0481	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VF_0483	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VF_0484	COG0779	Required for maturation of 30S ribosomal subunits
VF_0485	COG0195	Participates in both transcription termination and antitermination
VF_0486	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VF_0487	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VF_0488	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VF_0490	COG1185	polyribonucleotide nucleotidyltransferase activity
VF_0492	COG0826	peptidase U32
VF_0493	COG0826	peptidase U32
VF_0495	COG3154	lipid carrier protein
VF_0496	COG3153	acetyltransferase
VF_0499	COG0456	acetyltransferase
VF_0500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VF_0501	COG0084	hydrolase, TatD family'
VF_0502	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VF_0504	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VF_0505	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VF_0506	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VF_0507	COG0813	purine-nucleoside phosphorylase activity
VF_0509	COG0560	Phosphoserine phosphatase
VF_0513	COG4964	Belongs to the GSP D family
VF_0523	COG2885	chlorophyll binding
VF_0528	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VF_0529	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VF_0530	COG4628	conserved protein (DUF2132)
VF_0531	COG0402	S-adenosylhomocysteine deaminase activity
VF_0532	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VF_0533	COG1022	Amp-dependent synthetase and ligase
VF_0534	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VF_0536	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VF_0537	COG0527	aspartate kinase activity
VF_0539	COG5016	pyruvate
VF_0539	COG0511	ligase activity, forming carbon-carbon bonds
VF_0540	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VF_0541	COG1238	metal cluster binding
VF_0542	COG0612	Peptidase, M16
VF_0543	COG2918	glutathione biosynthetic process
VF_0546	COG4536	flavin adenine dinucleotide binding
VF_0547	COG4137	Cytochrome C assembly protein
VF_0548	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VF_0550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VF_0554	COG0287	Prephenate dehydrogenase
VF_0554	COG1605	Chorismate mutase
VF_0555	COG0739	heme binding
VF_0557	COG0488	(ABC) transporter
VF_0558	COG0741	lytic transglycosylase activity
VF_0559	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VF_0560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VF_0561	COG0077	Prephenate dehydratase
VF_0561	COG1605	Chorismate mutase
VF_0562	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VF_0563	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VF_0564	COG0564	pseudouridine synthase activity
VF_0565	COG1496	oxidoreductase activity
VF_0566	COG0542	response to heat
VF_0573	COG2059	Chromate
VF_0574	COG0583	DNA-binding transcription factor activity
VF_0576	COG2171	N-acyltransferase activity
VF_0577	COG3141	response to X-ray
VF_0581	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VF_0582	COG1074	ATP-dependent DNA helicase activity
VF_0583	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VF_0585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VF_0585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VF_0587	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VF_0588	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VF_0589	COG2166	iron-sulfur cluster assembly
VF_0590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VF_0591	COG0583	DNA-binding transcription factor activity
VF_0592	COG2363	Small membrane protein
VF_0593	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VF_0594	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VF_0595	COG1611	Belongs to the LOG family
VF_0598	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VF_0598	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VF_0600	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VF_0601	COG1671	Belongs to the UPF0178 family
VF_0604	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VF_0605	COG2723	6-phospho-beta-galactosidase activity
VF_0606	COG1940	carbohydrate kinase activity
VF_0607	COG1447	Phosphotransferase system cellobiose-specific component IIA
VF_0608	COG1609	Transcriptional regulator
VF_0612	COG3098	single-species biofilm formation
VF_0613	COG0564	pseudouridine synthase activity
VF_0614	COG0483	inositol monophosphate 1-phosphatase activity
VF_0615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VF_0616	COG1959	2 iron, 2 sulfur cluster binding
VF_0617	COG1104	cysteine desulfurase activity
VF_0618	COG0822	iron-sulfur transferase activity
VF_0619	COG0316	Belongs to the HesB IscA family
VF_0621	COG0443	Heat shock 70 kDa protein
VF_0623	COG2975	iron-sulfur cluster assembly
VF_0625	COG0105	UTP biosynthetic process
VF_0626	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VF_0629	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VF_0631	COG2976	Protein conserved in bacteria
VF_0632	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VF_0636	COG1570	exodeoxyribonuclease VII activity
VF_0637	COG0517	IMP dehydrogenase activity
VF_0637	COG0516	GMP reductase activity
VF_0638	COG0519	Catalyzes the synthesis of GMP from XMP
VF_0638	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VF_0639	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VF_0640	COG2964	Protein conserved in bacteria
VF_0641	COG3681	Belongs to the UPF0597 family
VF_0642	COG0251	oxidation-reduction process
VF_0643	COG0814	amino acid
VF_0645	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VF_0646	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VF_0647	COG1301	dicarboxylic acid transport
VF_0648	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VF_0650	COG0590	tRNA wobble adenosine to inosine editing
VF_0651	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VF_0652	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VF_0652	COG0047	phosphoribosylformylglycinamidine synthase activity
VF_0655	COG3325	Belongs to the glycosyl hydrolase 18 family
VF_0655	COG3469	chitinase activity
VF_0656	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VF_0658	COG0189	ligase activity
VF_0659	COG0189	ligase activity
VF_0659	COG4067	protein conserved in archaea
VF_0660	COG0733	neurotransmitter:sodium symporter activity
VF_0663	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VF_0664	COG1737	Transcriptional regulator
VF_0665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VF_0666	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VF_0668	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VF_0669	COG2731	YhcH YjgK YiaL family protein
VF_0670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VF_0671	COG0830	nickel cation binding
VF_0672	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VF_0673	COG0804	urea catabolic process
VF_0674	COG0832	Belongs to the urease beta subunit family
VF_0676	COG0829	nickel cation binding
VF_0678	COG0444	Belongs to the ABC transporter superfamily
VF_0679	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VF_0680	COG0601	transmembrane transport
VF_0682	COG0442	prolyl-tRNA aminoacylation
VF_0683	COG1720	tRNA m6t6A37 methyltransferase activity
VF_0684	COG1464	Belongs to the NlpA lipoprotein family
VF_0685	COG2011	ABC-type metal ion transport system permease component
VF_0686	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VF_0687	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VF_0688	COG4174	ABC transporter (Permease)
VF_0689	COG4239	(ABC) transporter, permease
VF_0690	COG0747	negative chemotaxis
VF_0691	COG0444	Belongs to the ABC transporter superfamily
VF_0692	COG4608	Belongs to the ABC transporter superfamily
VF_0696	COG3064	Membrane
VF_0698	COG0840	transmembrane signaling receptor activity
VF_0700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VF_0700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VF_0705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VF_0706	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VF_0708	COG5002	protein histidine kinase activity
VF_0708	COG0784	Response regulator, receiver
VF_0711	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VF_0712	COG0142	geranyltranstransferase activity
VF_0714	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VF_0715	COG1360	Flagellar Motor Protein
VF_0715	COG1360	Flagellar Motor Protein
VF_0716	COG0301	tRNA thio-modification
VF_0716	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VF_0717	COG0693	protein deglycase activity
VF_0718	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VF_0720	COG2807	transmembrane transport
VF_0721	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VF_0723	COG2813	Specifically methylates the guanine in position
VF_0724	COG0271	Belongs to the BolA IbaG family
VF_0726	COG1805	sodium ion transport
VF_0731	COG2871	sodium ion transport
VF_0732	COG1477	protein flavinylation
VF_0734	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VF_0735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VF_0736	COG2195	Cleaves the N-terminal amino acid of tripeptides
VF_0737	COG2252	PERMEase
VF_0738	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VF_0739	COG1073	alpha beta
VF_0740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VF_0741	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VF_0742	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VF_0743	COG0321	lipoyl(octanoyl) transferase activity
VF_0745	COG1686	Belongs to the peptidase S11 family
VF_0746	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VF_0747	COG0772	Belongs to the SEDS family
VF_0748	COG0768	penicillin binding
VF_0749	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VF_0750	COG0799	negative regulation of ribosome biogenesis
VF_0751	COG1466	dna polymerase III delta subunit
VF_0753	COG0495	leucyl-tRNA aminoacylation
VF_0754	COG2888	peptidyl-tyrosine sulfation
VF_0755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VF_0756	COG4535	Mg2 and Co2 transporter CorC
VF_0757	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VF_0758	COG1702	phosphate starvation-inducible protein PhoH
VF_0760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VF_0764	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VF_0765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VF_0767	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VF_0769	COG2890	protein-(glutamine-N5) methyltransferase activity
VF_0771	COG2912	Transglutaminase-like superfamily
VF_0773	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VF_0773	COG1648	precorrin-2 dehydrogenase activity
VF_0776	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VF_0777	COG0840	transmembrane signaling receptor activity
VF_0779	COG2840	Smr protein MutS2
VF_0781	COG2217	Heavy metal translocating P-type atpase
VF_0781	COG2608	mercury ion transmembrane transporter activity
VF_0782	COG0789	Transcriptional regulator
VF_0783	COG3118	belongs to the thioredoxin family
VF_0784	COG0300	oxidoreductase activity
VF_0785	COG2113	Glycine betaine
VF_0786	COG4176	ABC-type proline glycine betaine transport system permease component
VF_0788	COG1090	epimerase
VF_0789	COG0622	Phosphoesterase
VF_0791	COG3710	Transcriptional regulator
VF_0792	COG0326	Molecular chaperone. Has ATPase activity
VF_0794	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VF_0795	COG0544	peptidyl-prolyl cis-trans isomerase activity
VF_0797	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VF_0798	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VF_0799	COG0776	regulation of translation
VF_0800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VF_0801	COG1555	photosystem II stabilization
VF_0801	COG1596	polysaccharide export
VF_0802	COG3104	oligopeptide transport
VF_0803	COG0250	Participates in transcription elongation, termination and antitermination
VF_0804	COG0367	asparagine synthase
VF_0805	COG4651	solute:proton antiporter activity
VF_0805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VF_0806	COG1940	carbohydrate kinase activity
VF_0806	COG1846	Transcriptional regulator
VF_0807	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VF_0808	COG1263	PTS System
VF_0808	COG2190	(PTS) system
VF_0808	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VF_0810	COG0735	belongs to the Fur family
VF_0814	COG0596	Alpha beta hydrolase
VF_0815	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VF_0816	COG0033	Phosphoglucomutase
VF_0817	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VF_0818	COG0372	Belongs to the citrate synthase family
VF_0820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VF_0823	COG0567	Dehydrogenase, E1 component
VF_0824	COG0508	dehydrogenase complex catalyzes the overall conversion of
VF_0827	COG0840	transmembrane signaling receptor activity
VF_0828	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VF_0829	COG1121	(ABC) transporter
VF_0830	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VF_0831	COG0739	heme binding
VF_0836	COG0857	belongs to the CobB CobQ family
VF_0836	COG0280	phosphate acetyltransferase
VF_0837	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VF_0839	COG0018	arginyl-trna synthetase
VF_0840	COG3102	Protein conserved in bacteria
VF_0846	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VF_0847	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VF_0850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VF_0851	COG1216	Glycosyl transferase, family 2
VF_0859	COG1028	Short-chain dehydrogenase reductase Sdr
VF_0862	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VF_0864	COG1061	Type III restriction enzyme res subunit
VF_0865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VF_0869	COG3811	Belongs to the UPF0386 family
VF_0871	COG1309	transcriptional regulator
VF_0872	COG0840	transmembrane signaling receptor activity
VF_0874	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VF_0875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VF_0877	COG0583	DNA-binding transcription factor activity
VF_0881	COG2814	Major facilitator Superfamily
VF_0883	COG0702	epimerase
VF_0884	COG1136	(ABC) transporter
VF_0888	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VF_0890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VF_0891	COG1737	Transcriptional regulator
VF_0892	COG0076	glutamate decarboxylase activity
VF_0894	COG2431	L-lysine efflux transmembrane transporter activity
VF_0896	COG3070	regulator of competence-specific genes
VF_0899	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VF_0900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VF_0901	COG4988	ABC transporter
VF_0902	COG0492	ferredoxin-NADP+ reductase activity
VF_0903	COG0686	Belongs to the AlaDH PNT family
VF_0906	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VF_0907	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VF_0908	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VF_0909	COG3118	belongs to the thioredoxin family
VF_0911	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VF_0913	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VF_0914	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VF_0916	COG3139	Protein of unknown function (DUF1315)
VF_0917	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VF_0918	COG1454	alcohol dehydrogenase
VF_0918	COG1012	belongs to the aldehyde dehydrogenase family
VF_0922	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VF_0924	COG2056	Na+-H+ antiporter family
VF_0925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VF_0928	COG0346	lactoylglutathione lyase activity
VF_0929	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VF_0930	COG4660	Part of a membrane complex involved in electron transport
VF_0931	COG4659	FMN binding
VF_0932	COG4658	electron transport chain
VF_0933	COG4656	Part of a membrane complex involved in electron transport
VF_0935	COG4657	Part of a membrane complex involved in electron transport
VF_0936	COG0556	nucleotide-excision repair
VF_0937	COG2204	response regulator
VF_0938	COG2198	Histidine kinase
VF_0939	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VF_0940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VF_0942	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VF_0943	COG0314	molybdopterin synthase activity
VF_0944	COG0189	ligase activity
VF_0946	COG4067	protein conserved in archaea
VF_0946	COG0189	ligase activity
VF_0947	COG0500	methyltransferase
VF_0948	COG4106	trans-aconitate 2-methyltransferase activity
VF_0949	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VF_0951	COG0632	four-way junction helicase activity
VF_0952	COG2255	four-way junction helicase activity
VF_0953	COG1271	oxidase subunit
VF_0954	COG1294	oxidase, subunit
VF_0955	COG4890	Cyd operon protein YbgT
VF_0957	COG0824	Thioesterase
VF_0958	COG0811	peptide transport
VF_0962	COG0823	Involved in the tonB-independent uptake of proteins
VF_0963	COG2885	chlorophyll binding
VF_0964	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VF_0965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VF_0968	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VF_0971	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VF_0972	COG1595	DNA-templated transcription, initiation
VF_0973	COG2918	glutathione biosynthetic process
VF_0974	COG1132	(ABC) transporter
VF_0975	COG1132	(ABC) transporter
VF_0987	COG0840	transmembrane signaling receptor activity
VF_0990	COG0515	serine threonine protein kinase
VF_0990	COG2815	serine threonine protein kinase
VF_0998	COG3829	transcription factor binding
VF_1007	COG3923	Primosomal replication protein n
VF_1009	COG1199	ATP-dependent helicase activity
VF_1012	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VF_1013	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VF_1014	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VF_1015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VF_1015	COG0131	Imidazoleglycerol-phosphate dehydratase
VF_1016	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VF_1017	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VF_1018	COG0107	imidazoleglycerol-phosphate synthase activity
VF_1019	COG0140	phosphoribosyl-ATP diphosphatase activity
VF_1019	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VF_1020	COG0564	pseudouridine synthase activity
VF_1021	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VF_1021	COG0116	Belongs to the methyltransferase superfamily
VF_1023	COG2350	Protein conserved in bacteria
VF_1025	COG2917	probably involved in intracellular septation
VF_1026	COG1301	dicarboxylic acid transport
VF_1027	COG0159	tryptophan synthase activity
VF_1028	COG0133	tryptophan synthase activity
VF_1029	COG0135	phosphoribosylanthranilate isomerase activity
VF_1029	COG0134	indole-3-glycerol-phosphate synthase activity
VF_1031	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VF_1032	COG0512	Glutamine amidotransferase of anthranilate synthase
VF_1033	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VF_1034	COG0613	PHP domain protein
VF_1035	COG0009	L-threonylcarbamoyladenylate synthase
VF_1039	COG1028	Short-chain dehydrogenase reductase Sdr
VF_1040	COG0616	signal peptide processing
VF_1051	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VF_1052	COG0471	metal ion transport
VF_1053	COG4191	Histidine kinase
VF_1053	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VF_1055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VF_1056	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VF_1057	COG1280	lysine exporter protein (LysE YggA)
VF_1058	COG0179	Fumarylacetoacetate (FAA) hydrolase
VF_1061	COG3069	C4-dicarboxylate transmembrane transporter activity
VF_1062	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VF_1064	COG0076	glutamate decarboxylase activity
VF_1065	COG2985	domain, Protein
VF_1066	COG0583	DNA-binding transcription factor activity
VF_1067	COG2259	Doxx family
VF_1068	COG1741	Belongs to the pirin family
VF_1072	COG0583	DNA-binding transcription factor activity
VF_1074	COG2207	Transcriptional regulator
VF_1081	COG1309	transcriptional regulator
VF_1082	COG0625	glutathione transferase activity
VF_1083	COG0625	glutathione transferase activity
VF_1088	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VF_1089	COG2358	TRAP transporter, solute receptor (TAXI family
VF_1091	COG0840	transmembrane signaling receptor activity
VF_1092	COG0840	transmembrane signaling receptor activity
VF_1094	COG2226	methyltransferase
VF_1095	COG0583	DNA-binding transcription factor activity
VF_1096	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VF_1098	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VF_1106	COG1136	(ABC) transporter
VF_1106	COG0577	efflux transmembrane transporter activity
VF_1107	COG1136	(ABC) transporter
VF_1108	COG0484	heat shock protein binding
VF_1111	COG0583	DNA-binding transcription factor activity
VF_1114	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VF_1115	COG1263	PTS System
VF_1115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VF_1117	COG0840	transmembrane signaling receptor activity
VF_1122	COG1505	serine-type exopeptidase activity
VF_1128	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VF_1132	COG0366	Alpha amylase catalytic
VF_1133	COG0840	transmembrane signaling receptor activity
VF_1134	COG0537	adenosine 5'-monophosphoramidase activity
VF_1138	COG0840	transmembrane signaling receptor activity
VF_1140	COG2226	methyltransferase
VF_1143	COG1252	NADH dehydrogenase
VF_1144	COG0513	Belongs to the DEAD box helicase family
VF_1147	COG1966	Carbon starvation protein
VF_1148	COG3279	Response regulator of the LytR AlgR family
VF_1149	COG3275	phosphorelay sensor kinase activity
VF_1150	COG1584	GPR1 FUN34 yaaH family protein
VF_1152	COG0501	Belongs to the peptidase M48B family
VF_1155	COG1301	dicarboxylic acid transport
VF_1156	COG0402	S-adenosylhomocysteine deaminase activity
VF_1157	COG2989	Protein conserved in bacteria
VF_1158	COG3108	Peptidase M15
VF_1159	COG0017	Asparaginyl-tRNA synthetase
VF_1160	COG0720	synthase
VF_1163	COG1136	(ABC) transporter
VF_1163	COG0577	efflux transmembrane transporter activity
VF_1165	COG0577	efflux transmembrane transporter activity
VF_1165	COG1136	(ABC) transporter
VF_1167	COG0420	3'-5' exonuclease activity
VF_1168	COG0419	ATPase involved in DNA repair
VF_1171	COG0814	amino acid
VF_1172	COG0814	amino acid
VF_1176	COG1760	l-serine dehydratase
VF_1177	COG0814	amino acid
VF_1182	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VF_1186	COG0626	cystathionine gamma-synthase activity
VF_1188	COG1454	alcohol dehydrogenase
VF_1189	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VF_1194	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VF_1197	COG0814	amino acid
VF_1200	COG2203	Gaf domain
VF_1200	COG2199	diguanylate cyclase activity
VF_1201	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VF_1202	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VF_1203	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VF_1207	COG0443	Heat shock 70 kDa protein
VF_1210	COG4326	sporulation control protein
VF_1214	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VF_1216	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VF_1220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VF_1221	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VF_1222	COG4558	Periplasmic binding protein
VF_1223	COG0848	biopolymer transport protein
VF_1224	COG0811	peptide transport
VF_1225	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VF_1227	COG3721	Heme iron utilization protein
VF_1228	COG0748	coenzyme F420 binding
VF_1230	COG4104	PAAR repeat-containing protein
VF_1236	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VF_1236	COG0072	phenylalanine-tRNA ligase activity
VF_1238	COG2988	succinylglutamate desuccinylase activity
VF_1240	COG1666	GTP binding
VF_1241	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VF_1242	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VF_1245	COG3706	GGDEF domain
VF_1250	COG3069	C4-dicarboxylate transmembrane transporter activity
VF_1252	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VF_1253	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VF_1254	COG1757	Na H antiporter
VF_1255	COG1609	Transcriptional regulator
VF_1258	COG1607	acyl-coa hydrolase
VF_1260	COG1309	transcriptional regulator
VF_1264	COG0402	S-adenosylhomocysteine deaminase activity
VF_1266	COG0534	Mate efflux family protein
VF_1272	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VF_1274	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VF_1274	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VF_1275	COG3008	intermembrane lipid transfer
VF_1276	COG2995	paraquat-inducible protein a
VF_1277	COG1132	(ABC) transporter
VF_1278	COG1956	GAF domain-containing protein
VF_1280	COG0793	Belongs to the peptidase S41A family
VF_1282	COG0308	aminopeptidase N
VF_1285	COG0167	dihydroorotate dehydrogenase activity
VF_1287	COG0116	Belongs to the methyltransferase superfamily
VF_1287	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VF_1289	COG0488	(ABC) transporter
VF_1293	COG1067	ATP-dependent peptidase activity
VF_1294	COG3120	sequence-specific DNA binding
VF_1299	COG3278	Belongs to the heme-copper respiratory oxidase family
VF_1302	COG2010	Cytochrome c
VF_1304	COG2217	Heavy metal translocating P-type atpase
VF_1308	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VF_1310	COG0589	response to stress
VF_1315	COG3842	ATPase activity
VF_1317	COG1177	transmembrane transport
VF_1320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VF_1321	COG0583	DNA-binding transcription factor activity
VF_1322	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VF_1324	COG1357	PFAM Pentapeptide repeats (8 copies)
VF_1326	COG0110	maltose O-acetyltransferase activity
VF_1332	COG0534	Mate efflux family protein
VF_1333	COG0583	DNA-binding transcription factor activity
VF_1335	COG1418	mRNA catabolic process
VF_1337	COG0110	maltose O-acetyltransferase activity
VF_1338	COG1280	lysine exporter protein (LysE YggA)
VF_1344	COG0454	-acetyltransferase
VF_1345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VF_1347	COG2824	Alkylphosphonate utilization operon protein PhnA
VF_1349	COG1404	Belongs to the peptidase S8 family
VF_1353	COG2944	sequence-specific DNA binding
VF_1359	COG0437	4 iron, 4 sulfur cluster binding
VF_1360	COG0243	molybdopterin cofactor binding
VF_1360	COG3383	formate dehydrogenase (NAD+) activity
VF_1366	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VF_1367	COG3437	response regulator, receiver
VF_1367	COG0784	Response regulator, receiver
VF_1373	COG1914	H( )-stimulated, divalent metal cation uptake system
VF_1374	COG1984	allophanate hydrolase subunit 2
VF_1375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VF_1376	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VF_1378	COG0583	DNA-binding transcription factor activity
VF_1380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VF_1383	COG0826	peptidase U32
VF_1387	COG2897	thiosulfate sulfurtransferase activity
VF_1394	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VF_1400	COG3852	Histidine kinase
VF_1401	COG2204	response regulator
VF_1403	COG4662	Binding-protein-dependent transport system inner membrane component
VF_1405	COG0746	molybdenum cofactor guanylyltransferase activity
VF_1406	COG0303	'Molybdopterin
VF_1407	COG0653	protein targeting
VF_1408	COG1940	carbohydrate kinase activity
VF_1409	COG3148	PFAM DTW domain containing protein
VF_1410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VF_1411	COG0791	NLP P60 protein
VF_1414	COG0307	riboflavin synthase, alpha
VF_1415	COG0534	Mate efflux family protein
VF_1417	COG0641	radical SAM
VF_1425	COG0714	Associated with various cellular activities
VF_1427	COG3119	arylsulfatase activity
VF_1428	COG3119	arylsulfatase activity
VF_1430	COG3119	arylsulfatase activity
VF_1432	COG1342	Belongs to the UPF0251 family
VF_1439	COG0513	Belongs to the DEAD box helicase family
VF_1444	COG1869	D-ribose catabolic process
VF_1445	COG1129	ABC transporter
VF_1446	COG1172	Belongs to the binding-protein-dependent transport system permease family
VF_1447	COG1879	ABC-type sugar transport system periplasmic component
VF_1448	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VF_1449	COG1609	Transcriptional regulator
VF_1450	COG1793	dna ligase
VF_1454	COG1115	amino acid carrier protein
VF_1455	COG0668	transmembrane transport
VF_1456	COG1280	lysine exporter protein (LysE YggA)
VF_1457	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VF_1458	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VF_1459	COG0251	oxidation-reduction process
VF_1460	COG0583	DNA-binding transcription factor activity
VF_1464	COG0210	DNA helicase
VF_1465	COG0210	DNA helicase
VF_1467	COG0443	Heat shock 70 kDa protein
VF_1469	COG1396	sequence-specific DNA binding
VF_1470	COG3550	peptidyl-serine autophosphorylation
VF_1471	COG3046	protein related to deoxyribodipyrimidine photolyase
VF_1476	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VF_1477	COG0484	heat shock protein binding
VF_1479	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VF_1481	COG0768	penicillin binding
VF_1482	COG2925	Exonuclease
VF_1484	COG1346	cytolysis
VF_1485	COG0295	cytidine deaminase activity
VF_1486	COG0154	amidase activity
VF_1487	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VF_1488	COG1448	Aminotransferase
VF_1490	COG0583	DNA-binding transcription factor activity
VF_1496	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VF_1498	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VF_1500	COG1643	Atp-dependent helicase
VF_1502	COG1254	Belongs to the acylphosphatase family
VF_1505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VF_1508	COG3069	C4-dicarboxylate transmembrane transporter activity
VF_1509	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VF_1512	COG0500	methyltransferase
VF_1513	COG1823	symporter activity
VF_1515	COG3706	GGDEF domain
VF_1518	COG0443	Heat shock 70 kDa protein
VF_1523	COG0517	IMP dehydrogenase activity
VF_1523	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VF_1523	COG0617	tRNA 3'-terminal CCA addition
VF_1525	COG0247	lactate metabolic process
VF_1525	COG0277	FAD linked oxidase domain protein
VF_1527	COG0252	asparaginase activity
VF_1530	COG2188	Transcriptional regulator
VF_1532	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VF_1533	COG4597	amino acid ABC transporter
VF_1534	COG0765	amino acid transport
VF_1535	COG1126	abc transporter atp-binding protein
VF_1536	COG0670	Belongs to the BI1 family
VF_1543	COG2067	long-chain fatty acid transport protein
VF_1544	COG0671	phosphoesterase, PA-phosphatase related
VF_1545	COG0583	DNA-binding transcription factor activity
VF_1546	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VF_1548	COG4235	cytochrome complex assembly
VF_1548	COG3088	subunit of a heme lyase
VF_1549	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VF_1550	COG1138	Cytochrome C-type biogenesis protein
VF_1551	COG3301	Polysulphide reductase, NrfD
VF_1552	COG0437	4 iron, 4 sulfur cluster binding
VF_1557	COG1643	Atp-dependent helicase
VF_1558	COG0281	malic enzyme
VF_1560	COG2949	membrane
VF_1561	COG3706	GGDEF domain
VF_1565	COG1122	ATPase activity
VF_1568	COG1187	pseudouridine synthase activity
VF_1570	COG0745	RESPONSE REGULATOR receiver
VF_1571	COG3381	protein complex oligomerization
VF_1572	COG1609	Transcriptional regulator
VF_1573	COG3070	regulator of competence-specific genes
VF_1576	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VF_1577	COG1946	Acyl-CoA thioesterase
VF_1578	COG1522	sequence-specific DNA binding
VF_1579	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VF_1580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VF_1581	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VF_1582	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VF_1584	COG2999	glutathione oxidoreductase activity
VF_1590	COG1882	Formate acetyltransferase
VF_1591	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VF_1592	COG2850	peptidyl-arginine hydroxylation
VF_1595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VF_1596	COG0601	transmembrane transport
VF_1599	COG1435	thymidine kinase activity
VF_1600	COG0215	cysteine-tRNA ligase activity
VF_1601	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VF_1602	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VF_1603	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VF_1604	COG3012	SEC-C Motif Domain Protein
VF_1605	COG0733	neurotransmitter:sodium symporter activity
VF_1609	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VF_1611	COG0573	inorganic phosphate transmembrane transporter activity
VF_1612	COG0581	inorganic phosphate transmembrane transporter activity
VF_1613	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VF_1616	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VF_1618	COG0840	transmembrane signaling receptor activity
VF_1619	COG0784	Response regulator, receiver
VF_1619	COG5002	protein histidine kinase activity
VF_1619	COG2198	Histidine kinase
VF_1620	COG1879	ABC-type sugar transport system periplasmic component
VF_1621	COG1803	Methylglyoxal synthase
VF_1622	COG0210	DNA helicase
VF_1623	COG1289	transmembrane transporter activity
VF_1626	COG0322	excinuclease ABC activity
VF_1627	COG2197	response regulator
VF_1628	COG0417	DNA replication proofreading
VF_1630	COG1757	Na H antiporter
VF_1632	COG3713	MltA-interacting MipA family protein
VF_1633	COG2186	Transcriptional regulator
VF_1634	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VF_1635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VF_1636	COG0653	protein targeting
VF_1638	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VF_1639	COG3706	GGDEF domain
VF_1641	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VF_1642	COG1902	pentaerythritol trinitrate reductase activity
VF_1642	COG0446	pyridine nucleotide-disulphide oxidoreductase
VF_1643	COG0616	signal peptide processing
VF_1644	COG0252	asparaginase activity
VF_1645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VF_1646	COG1757	Na H antiporter
VF_1648	COG3081	Nucleoid-associated protein
VF_1650	COG3083	sulfuric ester hydrolase activity
VF_1651	COG3338	carbonate dehydratase activity
VF_1652	COG0840	transmembrane signaling receptor activity
VF_1653	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VF_1667	COG1441	menaquinone biosynthetic process
VF_1669	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VF_1671	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VF_1673	COG0436	Aminotransferase
VF_1674	COG4533	DNA binding
VF_1675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VF_1677	COG2207	Transcriptional regulator
VF_1678	COG1979	alcohol dehydrogenase
VF_1680	COG0697	spore germination
VF_1682	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VF_1687	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VF_1688	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VF_1689	COG0745	RESPONSE REGULATOR receiver
VF_1690	COG0583	DNA-binding transcription factor activity
VF_1691	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VF_1692	COG1286	toxin biosynthetic process
VF_1693	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VF_1694	COG0285	dihydrofolate synthase activity
VF_1695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VF_1698	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VF_1699	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VF_1700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VF_1701	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VF_1701	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VF_1702	COG2951	lytic endotransglycosylase activity
VF_1703	COG3100	YcgL domain-containing protein
VF_1704	COG0850	regulation of cytokinetic process
VF_1705	COG2894	cell division
VF_1707	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VF_1708	COG0318	PFAM AMP-dependent synthetase and ligase
VF_1710	COG3065	identical protein binding
VF_1712	COG1214	PFAM Peptidase M22, glycoprotease
VF_1713	COG1199	ATP-dependent helicase activity
VF_1714	COG0788	formyltetrahydrofolate deformylase activity
VF_1715	COG0596	Alpha beta hydrolase
VF_1716	COG1917	Cupin 2, conserved barrel domain protein
VF_1716	COG2207	Transcriptional regulator
VF_1717	COG0697	spore germination
VF_1718	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VF_1719	COG1263	PTS System
VF_1719	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VF_1720	COG1609	Transcriptional regulator
VF_1721	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VF_1722	COG0583	DNA-binding transcription factor activity
VF_1724	COG3069	C4-dicarboxylate transmembrane transporter activity
VF_1726	COG1032	radical SAM domain protein
VF_1730	COG0733	neurotransmitter:sodium symporter activity
VF_1733	COG0084	hydrolase, TatD family'
VF_1734	COG0470	DNA polymerase III
VF_1735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VF_1736	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VF_1738	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VF_1742	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VF_1745	COG1399	metal-binding, possibly nucleic acid-binding protein
VF_1746	COG0424	maF-like protein
VF_1747	COG0564	pseudouridine synthase activity
VF_1748	COG1530	ribonuclease E activity
VF_1749	COG0659	secondary active sulfate transmembrane transporter activity
VF_1750	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VF_1753	COG0489	protein tyrosine kinase activity
VF_1754	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VF_1754	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VF_1756	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VF_1757	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VF_1759	COG0539	negative regulation of cytoplasmic translation
VF_1760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VF_1761	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VF_1762	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VF_1764	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VF_1765	COG0542	response to heat
VF_1767	COG1278	Cold shock
VF_1769	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VF_1771	COG2766	serine protein kinase
VF_1773	COG2718	Belongs to the UPF0229 family
VF_1774	COG2719	SpoVR family
VF_1776	COG1187	pseudouridine synthase activity
VF_1778	COG0840	transmembrane signaling receptor activity
VF_1780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VF_1781	COG0446	pyridine nucleotide-disulphide oxidoreductase
VF_1782	COG0426	domain, Protein
VF_1782	COG1773	rubredoxin
VF_1783	COG3604	Transcriptional regulator
VF_1784	COG0482	sulfurtransferase activity
VF_1785	COG2915	High frequency lysogenization protein hflD homolog
VF_1786	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VF_1787	COG4977	sequence-specific DNA binding
VF_1787	COG1917	Cupin 2, conserved barrel domain protein
VF_1789	COG0840	transmembrane signaling receptor activity
VF_1790	COG0513	Belongs to the DEAD box helicase family
VF_1792	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VF_1793	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VF_1794	COG3013	Belongs to the UPF0304 family
VF_1795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VF_1796	COG2226	methyltransferase
VF_1798	COG0038	chloride channel
VF_1799	COG1560	Kdo2-lipid A biosynthetic process
VF_1802	COG3101	peptidyl-lysine hydroxylation
VF_1803	COG1285	pathogenesis
VF_1804	COG2860	membrane
VF_1805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VF_1806	COG2890	protein-(glutamine-N5) methyltransferase activity
VF_1808	COG2062	phosphohistidine phosphatase, SixA
VF_1809	COG1025	Belongs to the peptidase M16 family
VF_1810	COG1024	Enoyl-CoA hydratase
VF_1810	COG1250	3-hydroxyacyl-CoA dehydrogenase
VF_1811	COG0183	Belongs to the thiolase family
VF_1813	COG2067	long-chain fatty acid transport protein
VF_1815	COG2853	Lipoprotein
VF_1818	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VF_1819	COG1138	Cytochrome C-type biogenesis protein
VF_1820	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VF_1822	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VF_1823	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VF_1824	COG4133	protoheme IX ABC transporter activity
VF_1826	COG0835	chemotaxis
VF_1829	COG1192	Involved in chromosome partitioning
VF_1830	COG2201	protein-glutamate methylesterase activity
VF_1831	COG0643	Histidine kinase
VF_1831	COG0784	Response regulator, receiver
VF_1831	COG2198	Histidine kinase
VF_1832	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VF_1840	COG1684	flagellar biosynthetic protein fliR
VF_1841	COG1987	bacterial-type flagellum assembly
VF_1851	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VF_1853	COG1677	Flagellar hook-basal body complex protein FliE
VF_1858	COG1516	flagellar protein fliS
VF_1860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VF_1861	COG1334	flagellar protein FlaG
VF_1862	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VF_1863	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VF_1864	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VF_1865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VF_1869	COG3951	Flagellar rod assembly protein muramidase FlgJ
VF_1869	COG1705	Flagellar rod assembly protein muramidase FlgJ
VF_1870	COG1706	bacterial-type flagellum-dependent cell motility
VF_1872	COG4786	Flagellar basal body rod
VF_1873	COG4787	bacterial-type flagellum-dependent cell motility
VF_1877	COG1815	bacterial-type flagellum-dependent cell motility
VF_1878	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VF_1879	COG0784	Response regulator, receiver
VF_1879	COG0835	chemotaxis
VF_1881	COG2747	anti-sigma28 factor FlgM
VF_1887	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VF_1890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VF_1891	COG3115	cell septum assembly
VF_1894	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VF_1897	COG2190	(PTS) system
VF_1898	COG2837	iron assimilation
VF_1903	COG3005	denitrification pathway
VF_1905	COG0243	molybdopterin cofactor binding
VF_1907	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VF_1908	COG3850	Histidine kinase
VF_1909	COG2197	response regulator
VF_1913	COG1393	Belongs to the ArsC family
VF_1914	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VF_1915	COG1876	peptidase activity
VF_1917	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VF_1918	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VF_1919	COG2716	regulation of RNA biosynthetic process
VF_1920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VF_1922	COG4783	chaperone-mediated protein folding
VF_1923	COG1393	Belongs to the ArsC family
VF_1928	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VF_1929	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VF_1930	COG0121	glutamine amidotransferase
VF_1931	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VF_1932	COG1960	acyl-CoA dehydrogenase activity
VF_1936	COG0328	RNA-DNA hybrid ribonuclease activity
VF_1937	COG2226	methyltransferase
VF_1938	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VF_1939	COG1388	LysM domain
VF_1939	COG0741	lytic transglycosylase activity
VF_1946	COG0825	malonyl-CoA metabolic process
VF_1947	COG0587	DNA-directed DNA polymerase activity
VF_1948	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VF_1949	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VF_1952	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VF_1953	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VF_1955	COG0750	zinc metalloprotease
VF_1956	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VF_1957	COG0575	Belongs to the CDS family
VF_1958	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VF_1959	COG0233	cytoplasmic translational termination
VF_1960	COG0528	UMP kinase activity
VF_1961	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VF_1963	COG0024	Methionine aminopeptidase
VF_1964	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VF_1966	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VF_1967	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VF_1968	COG1862	Preprotein translocase
VF_1970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VF_1971	COG0517	IMP dehydrogenase activity
VF_1973	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VF_1974	COG0583	DNA-binding transcription factor activity
VF_1975	COG0450	alkyl hydroperoxide reductase
VF_1976	COG3142	Participates in the control of copper homeostasis
VF_1977	COG3111	PFAM Bacterial OB fold (BOF) protein
VF_1982	COG0704	Plays a role in the regulation of phosphate uptake
VF_1983	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VF_1984	COG0581	inorganic phosphate transmembrane transporter activity
VF_1987	COG5002	protein histidine kinase activity
VF_1988	COG0745	RESPONSE REGULATOR receiver
VF_1990	COG0826	peptidase U32
VF_1991	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VF_1993	COG0484	heat shock protein binding
VF_1994	COG0443	Heat shock 70 kDa protein
VF_1996	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VF_1997	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VF_1998	COG0497	DNA recombination
VF_1999	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VF_2000	COG2914	Belongs to the UPF0125 (RnfH) family
VF_2001	COG2867	negative regulation of translational initiation
VF_2002	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VF_2008	COG4386	tail sheath protein
VF_2015	COG4695	Portal protein
VF_2041	COG4974	Belongs to the 'phage' integrase family
VF_2044	COG1175	transmembrane transport
VF_2045	COG3833	ABC-type maltose transport systems, permease component
VF_2046	COG3842	ATPase activity
VF_2051	COG0583	DNA-binding transcription factor activity
VF_2052	COG2239	Acts as a magnesium transporter
VF_2055	COG1858	cytochrome C peroxidase
VF_2056	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VF_2057	COG1982	Orn Lys Arg decarboxylase major
VF_2058	COG0531	amino acid
VF_2059	COG1115	amino acid carrier protein
VF_2060	COG3710	Transcriptional regulator
VF_2064	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VF_2065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VF_2066	COG5413	integral membrane protein
VF_2067	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VF_2069	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VF_2070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VF_2071	COG0585	pseudouridine synthase activity
VF_2072	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VF_2073	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VF_2075	COG0148	phosphopyruvate hydratase activity
VF_2076	COG0504	CTP synthase activity
VF_2078	COG3956	TIGRFAM MazG family protein
VF_2080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VF_2081	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VF_2083	COG0736	holo-[acyl-carrier-protein] synthase activity
VF_2084	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VF_2086	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VF_2087	COG0571	ribonuclease III activity
VF_2088	COG0681	Belongs to the peptidase S26 family
VF_2089	COG0481	GTPase activity
VF_2091	COG3026	antisigma factor binding
VF_2093	COG1595	DNA-templated transcription, initiation
VF_2094	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VF_2096	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VF_2097	COG0354	folic acid binding
VF_2100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VF_2101	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VF_2102	COG3079	Belongs to the UPF0149 family
VF_2103	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VF_2104	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VF_2106	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VF_2108	COG0668	transmembrane transport
VF_2109	COG3022	response to hydroperoxide
VF_2110	COG1115	amino acid carrier protein
VF_2113	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VF_2114	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VF_2116	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VF_2117	COG0083	homoserine kinase activity
VF_2119	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VF_2120	COG0745	RESPONSE REGULATOR receiver
VF_2122	COG0784	Response regulator, receiver
VF_2122	COG5002	protein histidine kinase activity
VF_2122	COG2198	Histidine kinase
VF_2123	COG1242	4 iron, 4 sulfur cluster binding
VF_2124	COG0067	glutamate synthase
VF_2124	COG0070	glutamate synthase
VF_2124	COG0069	glutamate synthase activity
VF_2130	COG2860	membrane
VF_2131	COG0739	heme binding
VF_2133	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VF_2135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VF_2136	COG0628	permease
VF_2137	COG2813	Specifically methylates the guanine in position
VF_2138	COG2205	protein histidine kinase activity
VF_2138	COG0784	Response regulator, receiver
VF_2139	COG0747	negative chemotaxis
VF_2141	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VF_2142	COG0444	Belongs to the ABC transporter superfamily
VF_2143	COG4608	Belongs to the ABC transporter superfamily
VF_2145	COG2971	BadF BadG BcrA BcrD
VF_2148	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VF_2151	COG1840	ABC-type Fe3 transport system, periplasmic component
VF_2152	COG0004	ammonium transporteR
VF_2155	COG3835	regulator
VF_2156	COG2610	gluconate transmembrane transporter activity
VF_2157	COG1929	Belongs to the glycerate kinase type-1 family
VF_2158	COG1049	propionate catabolic process, 2-methylcitrate cycle
VF_2159	COG1752	Esterase of the alpha-beta hydrolase superfamily
VF_2162	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VF_2163	COG1643	Atp-dependent helicase
VF_2164	COG1489	DNA binding
VF_2168	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VF_2169	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VF_2170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VF_2171	COG0842	Transport permease protein
VF_2172	COG1131	(ABC) transporter
VF_2173	COG0659	secondary active sulfate transmembrane transporter activity
VF_2174	COG0288	reversible hydration of carbon dioxide
VF_2178	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VF_2179	COG0508	dehydrogenase complex catalyzes the overall conversion of
VF_2181	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VF_2182	COG2186	Transcriptional regulator
VF_2184	COG0157	Belongs to the NadC ModD family
VF_2185	COG4969	Belongs to the N-Me-Phe pilin family
VF_2186	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VF_2187	COG1459	type II secretion system
VF_2189	COG0237	dephospho-CoA kinase activity
VF_2190	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VF_2191	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VF_2192	COG0494	nUDIX hydrolase
VF_2193	COG0653	protein targeting
VF_2195	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VF_2196	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VF_2197	COG0849	cell division
VF_2199	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VF_2200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VF_2201	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VF_2202	COG0772	Belongs to the SEDS family
VF_2203	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VF_2204	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VF_2205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VF_2207	COG0768	penicillin binding
VF_2208	COG3116	cell division
VF_2209	COG0275	rRNA processing
VF_2210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VF_2211	COG3107	peptidoglycan biosynthetic process
VF_2213	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VF_2215	COG2969	positive regulation of protein catabolic process
VF_2216	COG0625	glutathione transferase activity
VF_2217	COG2857	Cytochrome c1
VF_2218	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VF_2220	COG0723	plastoquinol--plastocyanin reductase activity
VF_2223	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VF_2224	COG3105	Protein conserved in bacteria
VF_2226	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VF_2228	COG0187	DNA topoisomerase II activity
VF_2229	COG3150	esterase
VF_2231	COG3151	Protein conserved in bacteria
VF_2232	COG0494	nUDIX hydrolase
VF_2233	COG1538	Outer membrane efflux protein
VF_2234	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VF_2234	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VF_2235	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VF_2237	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VF_2238	COG3025	triphosphatase activity
VF_2239	COG1392	Phosphate transport regulator
VF_2240	COG0306	phosphate transporter
VF_2241	COG4991	sh3 domain protein
VF_2243	COG3267	Type II secretory pathway component ExeA
VF_2243	COG3409	Peptidoglycan-binding domain 1 protein
VF_2244	COG0617	tRNA 3'-terminal CCA addition
VF_2245	COG1968	undecaprenyl-diphosphatase activity
VF_2246	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VF_2247	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VF_2251	COG1610	YqeY-like protein
VF_2252	COG0358	DNA primase activity
VF_2256	COG0318	PFAM AMP-dependent synthetase and ligase
VF_2261	COG5001	Diguanylate cyclase
VF_2261	COG3447	MASE1 domain protein
VF_2261	COG5002	protein histidine kinase activity
VF_2262	COG0440	acetolactate synthase activity
VF_2263	COG0028	Belongs to the TPP enzyme family
VF_2264	COG1022	Amp-dependent synthetase and ligase
VF_2265	COG0583	DNA-binding transcription factor activity
VF_2266	COG0527	aspartate kinase activity
VF_2266	COG0460	homoserine dehydrogenase
VF_2267	COG0626	cystathionine gamma-synthase activity
VF_2269	COG0366	Alpha amylase catalytic
VF_2272	COG0281	malic enzyme
VF_2274	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VF_2275	COG1609	Transcriptional regulator
VF_2278	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VF_2279	COG1765	OsmC-like protein
VF_2280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VF_2282	COG1012	belongs to the aldehyde dehydrogenase family
VF_2284	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VF_2285	COG0512	Glutamine amidotransferase of anthranilate synthase
VF_2286	COG0180	Tryptophanyl-tRNA synthetase
VF_2287	COG0546	phosphoglycolate phosphatase activity
VF_2288	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VF_2289	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VF_2298	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VF_2300	COG0678	peroxiredoxin activity
VF_2300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VF_2301	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VF_2303	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VF_2303	COG0165	Argininosuccinate lyase
VF_2304	COG0137	argininosuccinate synthase activity
VF_2306	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VF_2307	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VF_2308	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VF_2309	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VF_2313	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VF_2314	COG0557	exoribonuclease II activity
VF_2316	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VF_2316	COG1017	nitric oxide dioxygenase activity
VF_2317	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VF_2318	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VF_2319	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VF_2320	COG0330	HflC and HflK could
VF_2321	COG0330	HflC and HflK could
VF_2322	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VF_2324	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VF_2325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VF_2327	COG0802	atpase or kinase
VF_2328	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VF_2329	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VF_2330	COG1162	GTPase activity
VF_2331	COG0688	phosphatidylethanolamine metabolic process
VF_2333	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VF_2334	COG1053	succinate dehydrogenase
VF_2335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VF_2338	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VF_2339	COG1509	lysine 2,3-aminomutase activity
VF_2343	COG0745	RESPONSE REGULATOR receiver
VF_2344	COG2205	protein histidine kinase activity
VF_2345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VF_2347	COG1045	serine acetyltransferase
VF_2348	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VF_2350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VF_2351	COG4942	peptidase
VF_2353	COG1027	Aspartate ammonia-lyase
VF_2354	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VF_2355	COG0589	response to stress
VF_2356	COG4232	protein-disulfide reductase activity
VF_2360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VF_2361	COG0640	Transcriptional regulator
VF_2364	COG1252	NADH dehydrogenase
VF_2367	COG1121	(ABC) transporter
VF_2368	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VF_2370	COG0523	cobalamin synthesis protein
VF_2372	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VF_2373	COG1349	DNA-binding transcription factor activity
VF_2375	COG2095	MarC family integral membrane protein
VF_2377	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VF_2379	COG2205	protein histidine kinase activity
VF_2380	COG2814	Major facilitator Superfamily
VF_2383	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VF_2386	COG0511	ligase activity, forming carbon-carbon bonds
VF_2387	COG0439	Biotin carboxylase
VF_2389	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VF_2394	COG0138	bifunctional purine biosynthesis protein purh
VF_2395	COG0151	Belongs to the GarS family
VF_2398	COG1253	flavin adenine dinucleotide binding
VF_2399	COG3068	Protein conserved in bacteria
VF_2400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VF_2403	COG2816	NAD+ diphosphatase activity
VF_2404	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VF_2412	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VF_2414	COG0085	RNA polymerase activity
VF_2418	COG0081	regulation of translation
VF_2421	COG0250	Participates in transcription elongation, termination and antitermination
VF_2422	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VF_2424	COG1072	(Pantothenic acid kinase))
VF_2426	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VF_2428	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VF_2433	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VF_2438	COG1309	transcriptional regulator
VF_2439	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VF_2440	COG0534	Mate efflux family protein
VF_2442	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VF_2443	COG2937	Belongs to the GPAT DAPAT family
VF_2444	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VF_2445	COG3161	chorismate lyase activity
VF_2446	COG1580	Controls the rotational direction of flagella during chemotaxis
VF_2447	COG0705	Rhomboid family
VF_2448	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VF_2451	COG2177	Part of the ABC transporter FtsEX involved in
VF_2452	COG2884	Cell division ATP-binding protein ftsE
VF_2453	COG0552	protein localization to endoplasmic reticulum
VF_2454	COG0742	ribosomal rna small subunit methyltransferase
VF_2456	COG2095	MarC family integral membrane protein
VF_2460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VF_2462	COG1218	3'(2'),5'-bisphosphate nucleotidase
VF_2463	COG0494	nUDIX hydrolase
VF_2465	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VF_2466	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VF_2467	COG3156	type II secretion system protein K
VF_2468	COG4795	General secretion pathway protein
VF_2469	COG2165	general secretion pathway protein
VF_2470	COG2165	general secretion pathway protein
VF_2471	COG2165	general secretion pathway protein
VF_2472	COG1459	type II secretion system
VF_2473	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VF_2475	COG3031	protein transport across the cell outer membrane
VF_2476	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VF_2480	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VF_2481	COG2267	carboxylic ester hydrolase activity
VF_2482	COG0561	phosphatase activity
VF_2483	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VF_2484	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VF_2485	COG0019	diaminopimelate decarboxylase activity
VF_2486	COG1965	Belongs to the frataxin family
VF_2488	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VF_2489	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VF_2493	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VF_2494	COG4232	protein-disulfide reductase activity
VF_2496	COG0515	serine threonine protein kinase
VF_2507	COG3964	amidohydrolase
VF_2510	COG3711	transcriptional antiterminator
VF_2510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VF_2513	COG0517	IMP dehydrogenase activity
VF_2515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VF_2516	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VF_2517	COG0601	transmembrane transport
VF_2518	COG0747	negative chemotaxis
VF_2522	COG1309	transcriptional regulator
VF_2523	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VF_2524	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VF_2525	COG2960	long-chain fatty acid transporting porin activity
VF_2528	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VF_2529	COG0583	DNA-binding transcription factor activity
VF_2533	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VF_2535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VF_2536	COG0009	L-threonylcarbamoyladenylate synthase
VF_2537	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VF_2538	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VF_2539	COG0551	DNA topoisomerase type I activity
VF_2540	COG2922	Belongs to the Smg family
VF_2541	COG0758	DNA mediated transformation
VF_2542	COG1652	LysM domain
VF_2544	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VF_2545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VF_2545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VF_2546	COG0569	domain protein
VF_2547	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VF_2548	COG1272	protein, Hemolysin III
VF_2550	COG3084	Protein conserved in bacteria
VF_2552	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VF_2553	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VF_2554	COG0204	Acyl-transferase
VF_2555	COG0606	chelatase, subunit chli
VF_2557	COG3978	acetolactate synthase activity
VF_2558	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VF_2561	COG1278	Cold shock
VF_2563	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VF_2564	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VF_2565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VF_2567	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VF_2571	COG3312	ion transport
VF_2572	COG1475	DNA binding
VF_2573	COG1192	Involved in chromosome partitioning
VF_2574	COG0357	Ribosomal RNA small subunit methyltransferase G
VF_2591	COG1546	Belongs to the CinA family
VF_2592	COG3630	sodium ion export across plasma membrane
VF_2602	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VF_2629	COG0401	homolog of Blt101
VF_2656	COG2965	DNA replication, synthesis of RNA primer
VF_A0010	COG0187	DNA topoisomerase II activity
VF_A0023	COG0183	Belongs to the thiolase family
VF_A0025	COG1024	Enoyl-CoA hydratase
VF_A0025	COG1250	3-hydroxyacyl-CoA dehydrogenase
VF_A0058	COG0248	Ppx GppA phosphatase
VF_A0076	COG2271	Major facilitator Superfamily
VF_A0121	COG2267	carboxylic ester hydrolase activity
VF_A0221	COG0545	Peptidyl-prolyl cis-trans isomerase
VF_A0255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VF_A0333	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VF_A0362	COG1530	ribonuclease E activity
VF_A0371	COG2239	Acts as a magnesium transporter
VF_A0443	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VF_A0474	COG0813	purine-nucleoside phosphorylase activity
VF_A0495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VF_A0497	COG1022	Amp-dependent synthetase and ligase
VF_A0504	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VF_A0524	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VF_A0538	COG0542	response to heat
VF_A0553	COG1074	ATP-dependent DNA helicase activity
VF_A0557	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VF_A0630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VF_A0657	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VF_A0674	COG0442	prolyl-tRNA aminoacylation
VF_A0730	COG1702	phosphate starvation-inducible protein PhoH
VF_A0751	COG0840	transmembrane signaling receptor activity
VF_A0755	COG2217	Heavy metal translocating P-type atpase
VF_A0758	COG2217	Heavy metal translocating P-type atpase
VF_A0758	COG2608	mercury ion transmembrane transporter activity
VF_A0763	COG4176	ABC-type proline glycine betaine transport system permease component
VF_A0771	COG0326	Molecular chaperone. Has ATPase activity
VF_A0803	COG0567	Dehydrogenase, E1 component
VF_A0838	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VF_A0918	COG0500	methyltransferase
VF_A0995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VF_A1027	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VF_A1032	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VF_A1063	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VF_A1069	COG0840	transmembrane signaling receptor activity
VF_A1141	COG3108	Peptidase M15
VF_A1185	COG1940	carbohydrate kinase activity
VF_AR0003	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VF_B0004	COG0706	membrane insertase activity
VF_B0020	COG0187	DNA topoisomerase II activity
VF_B0021	COG0187	DNA topoisomerase II activity
VF_B0028	COG0751	glycine-tRNA ligase activity