locus-tag	class	description
GPY18_RS00015	COG0366	Alpha amylase catalytic
GPY18_RS00035	COG0714	Associated with various cellular activities
GPY18_RS00055	COG2304	oxidoreductase activity
GPY18_RS00070	COG3706	GGDEF domain
GPY18_RS00080	COG0784	Response regulator, receiver
GPY18_RS00080	COG2205	protein histidine kinase activity
GPY18_RS00080	COG5002	protein histidine kinase activity
GPY18_RS00085	COG0745	RESPONSE REGULATOR receiver
GPY18_RS00085	COG3706	GGDEF domain
GPY18_RS00095	COG3724	N-succinylarginine dihydrolase activity
GPY18_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
GPY18_RS00125	COG4948	Mandelate Racemase Muconate Lactonizing
GPY18_RS00150	COG0583	DNA-binding transcription factor activity
GPY18_RS00175	COG3171	Protein conserved in bacteria
GPY18_RS00180	COG0589	response to stress
GPY18_RS00190	COG3530	Putative quorum-sensing-regulated virulence factor
GPY18_RS00200	COG0579	oxidoreductase
GPY18_RS00215	COG2204	response regulator
GPY18_RS00225	COG1929	Belongs to the glycerate kinase type-1 family
GPY18_RS00230	COG0383	alpha-mannosidase activity
GPY18_RS00235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS00235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS00235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS00240	COG2188	Transcriptional regulator
GPY18_RS00265	COG5001	Diguanylate cyclase
GPY18_RS00265	COG3300	MHYT domain
GPY18_RS00270	COG2271	Major facilitator Superfamily
GPY18_RS00275	COG0584	glycerophosphoryl diester phosphodiesterase
GPY18_RS00280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY18_RS00285	COG0583	DNA-binding transcription factor activity
GPY18_RS00295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY18_RS00300	COG1879	ABC-type sugar transport system periplasmic component
GPY18_RS00305	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY18_RS00310	COG1129	ABC transporter
GPY18_RS00315	COG1869	D-ribose catabolic process
GPY18_RS00330	COG3501	Rhs element vgr protein
GPY18_RS00425	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS00430	COG1846	Transcriptional regulator
GPY18_RS00445	COG0564	pseudouridine synthase activity
GPY18_RS00450	COG1309	transcriptional regulator
GPY18_RS00455	COG2130	NADP-dependent
GPY18_RS00470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY18_RS00500	COG3842	ATPase activity
GPY18_RS00510	COG2200	EAL domain
GPY18_RS00515	COG0656	L-ascorbic acid biosynthetic process
GPY18_RS00520	COG1902	pentaerythritol trinitrate reductase activity
GPY18_RS00525	COG0583	DNA-binding transcription factor activity
GPY18_RS00530	COG2814	Major facilitator Superfamily
GPY18_RS00550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY18_RS00565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY18_RS00575	COG4702	Belongs to the UPF0303 family
GPY18_RS00580	COG0673	inositol 2-dehydrogenase activity
GPY18_RS00585	COG1349	DNA-binding transcription factor activity
GPY18_RS00590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY18_RS00610	COG3240	lipase activity
GPY18_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS00620	COG0583	DNA-binding transcription factor activity
GPY18_RS00630	COG1120	ATPase activity
GPY18_RS00635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY18_RS00640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY18_RS00645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY18_RS00650	COG4774	siderophore transport
GPY18_RS00675	COG0840	transmembrane signaling receptor activity
GPY18_RS00680	COG3384	dioxygenase
GPY18_RS00685	COG0583	DNA-binding transcription factor activity
GPY18_RS00695	COG1342	Belongs to the UPF0251 family
GPY18_RS00700	COG0778	Nitroreductase
GPY18_RS00705	COG0583	DNA-binding transcription factor activity
GPY18_RS00715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY18_RS00720	COG0697	spore germination
GPY18_RS00735	COG2814	Major facilitator Superfamily
GPY18_RS00740	COG0583	DNA-binding transcription factor activity
GPY18_RS00745	COG5001	Diguanylate cyclase
GPY18_RS00745	COG3300	MHYT domain
GPY18_RS00750	COG0739	heme binding
GPY18_RS00765	COG0659	secondary active sulfate transmembrane transporter activity
GPY18_RS00780	COG2199	diguanylate cyclase activity
GPY18_RS00790	COG0581	inorganic phosphate transmembrane transporter activity
GPY18_RS00795	COG0573	inorganic phosphate transmembrane transporter activity
GPY18_RS00800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY18_RS00805	COG0840	transmembrane signaling receptor activity
GPY18_RS00810	COG0513	Belongs to the DEAD box helicase family
GPY18_RS00820	COG1376	ErfK ybiS ycfS ynhG family protein
GPY18_RS00820	COG1388	LysM domain
GPY18_RS00825	COG0415	Belongs to the DNA photolyase family
GPY18_RS00835	COG3272	Protein of unknown function (DUF1722)
GPY18_RS00840	COG0813	purine-nucleoside phosphorylase activity
GPY18_RS00855	COG3706	GGDEF domain
GPY18_RS00865	COG1566	PFAM secretion protein HlyD family protein
GPY18_RS00900	COG0786	glutamate:sodium symporter activity
GPY18_RS00915	COG1999	signal sequence binding
GPY18_RS00925	COG1162	GTPase activity
GPY18_RS00930	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY18_RS00945	COG4580	involved in the transport of maltose and maltodextrins
GPY18_RS00960	COG1132	(ABC) transporter
GPY18_RS00970	COG0671	phosphoesterase, PA-phosphatase related
GPY18_RS00980	COG3383	formate dehydrogenase (NAD+) activity
GPY18_RS00995	COG0840	transmembrane signaling receptor activity
GPY18_RS01005	COG1131	(ABC) transporter
GPY18_RS01010	COG2188	Transcriptional regulator
GPY18_RS01020	COG3033	Beta-eliminating lyase
GPY18_RS01025	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY18_RS01030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY18_RS01040	COG0471	metal ion transport
GPY18_RS01085	COG3501	Rhs element vgr protein
GPY18_RS01095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY18_RS01100	COG1640	4-alpha-glucanotransferase
GPY18_RS01105	COG0058	SHG alpha-glucan phosphorylase activity
GPY18_RS01110	COG2909	trisaccharide binding
GPY18_RS01125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY18_RS01130	COG1845	cytochrome c oxidase, subunit III
GPY18_RS01135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY18_RS01140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY18_RS01155	COG2084	Dehydrogenase
GPY18_RS01170	COG0217	transcriptional regulatory protein
GPY18_RS01205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY18_RS01220	COG0745	RESPONSE REGULATOR receiver
GPY18_RS01225	COG0643	Histidine kinase
GPY18_RS01225	COG2198	Histidine kinase
GPY18_RS01230	COG0835	chemotaxis
GPY18_RS01235	COG0835	chemotaxis
GPY18_RS01240	COG0840	transmembrane signaling receptor activity
GPY18_RS01245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY18_RS01255	COG2201	protein-glutamate methylesterase activity
GPY18_RS01270	COG0745	RESPONSE REGULATOR receiver
GPY18_RS01300	COG0259	pyridoxamine-phosphate oxidase activity
GPY18_RS01310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY18_RS01340	COG0840	transmembrane signaling receptor activity
GPY18_RS01355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY18_RS01360	COG0513	Belongs to the DEAD box helicase family
GPY18_RS01370	COG0583	DNA-binding transcription factor activity
GPY18_RS01375	COG2226	methyltransferase
GPY18_RS01390	COG0724	RNA recognition motif
GPY18_RS01395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY18_RS01400	COG1522	sequence-specific DNA binding
GPY18_RS01405	COG2610	gluconate transmembrane transporter activity
GPY18_RS01410	COG3622	Belongs to the hyi family
GPY18_RS01415	COG0235	Class ii aldolase
GPY18_RS01420	COG3395	kinase activity
GPY18_RS01425	COG2084	Dehydrogenase
GPY18_RS01430	COG1349	DNA-binding transcription factor activity
GPY18_RS01445	COG0583	DNA-binding transcription factor activity
GPY18_RS01450	COG2910	NAD(P)H-binding
GPY18_RS01465	COG1335	isochorismatase
GPY18_RS01470	COG1609	Transcriptional regulator
GPY18_RS01470	COG2207	Transcriptional regulator
GPY18_RS01485	COG2329	Antibiotic biosynthesis monooxygenase
GPY18_RS01490	COG3304	Inner membrane component domain
GPY18_RS01500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS01525	COG0583	DNA-binding transcription factor activity
GPY18_RS01530	COG4221	oxidoreductase activity
GPY18_RS01550	COG1403	HNH endonuclease
GPY18_RS01560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY18_RS01610	COG2176	DNA-directed DNA polymerase activity
GPY18_RS01630	COG0443	Heat shock 70 kDa protein
GPY18_RS01635	COG0095	Lipoate-protein ligase
GPY18_RS01650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY18_RS01655	COG1473	amidohydrolase
GPY18_RS01670	COG3722	fumarate hydratase activity
GPY18_RS01680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS01680	COG2213	PTS system mannitol-specific
GPY18_RS01685	COG0739	heme binding
GPY18_RS01700	COG0363	glucosamine-6-phosphate deaminase activity
GPY18_RS01725	COG0402	S-adenosylhomocysteine deaminase activity
GPY18_RS01730	COG2259	Doxx family
GPY18_RS01735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY18_RS01740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY18_RS01750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY18_RS01755	COG1301	dicarboxylic acid transport
GPY18_RS01770	COG1917	Cupin 2, conserved barrel domain protein
GPY18_RS01770	COG2169	Transcriptional regulator
GPY18_RS01805	COG1764	response to oxidative stress
GPY18_RS01810	COG1846	Transcriptional regulator
GPY18_RS01815	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY18_RS01835	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS01845	COG1902	pentaerythritol trinitrate reductase activity
GPY18_RS01850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY18_RS01860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY18_RS01865	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY18_RS01890	COG1612	heme a metabolic process
GPY18_RS01895	COG0109	protoheme IX farnesyltransferase activity
GPY18_RS01910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY18_RS01920	COG5002	protein histidine kinase activity
GPY18_RS01920	COG5001	Diguanylate cyclase
GPY18_RS01920	COG3447	MASE1 domain protein
GPY18_RS01940	COG2169	Transcriptional regulator
GPY18_RS01960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS01965	COG0697	spore germination
GPY18_RS01970	COG0477	Major facilitator Superfamily
GPY18_RS01975	COG0625	glutathione transferase activity
GPY18_RS01985	COG1942	4-Oxalocrotonate Tautomerase
GPY18_RS02000	COG0583	DNA-binding transcription factor activity
GPY18_RS02020	COG3152	Membrane
GPY18_RS02030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY18_RS02040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY18_RS02065	COG1304	FMN binding
GPY18_RS02070	COG1620	l-lactate permease
GPY18_RS02075	COG0583	DNA-binding transcription factor activity
GPY18_RS02080	COG4172	Belongs to the ABC transporter superfamily
GPY18_RS02090	COG1067	ATP-dependent peptidase activity
GPY18_RS02100	COG2211	Major facilitator Superfamily
GPY18_RS02105	COG0668	transmembrane transport
GPY18_RS02110	COG0569	domain protein
GPY18_RS02115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY18_RS02125	COG3123	guanosine phosphorylase activity
GPY18_RS02130	COG1741	Belongs to the pirin family
GPY18_RS02140	COG5001	Diguanylate cyclase
GPY18_RS02165	COG3706	GGDEF domain
GPY18_RS02185	COG3706	GGDEF domain
GPY18_RS02195	COG1846	Transcriptional regulator
GPY18_RS02200	COG2315	Protein conserved in bacteria
GPY18_RS02205	COG0784	Response regulator, receiver
GPY18_RS02205	COG0835	chemotaxis
GPY18_RS02210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY18_RS02220	COG1942	4-Oxalocrotonate Tautomerase
GPY18_RS02240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY18_RS02260	COG1522	sequence-specific DNA binding
GPY18_RS02270	COG0393	Putative heavy-metal-binding
GPY18_RS02275	COG0823	Involved in the tonB-independent uptake of proteins
GPY18_RS02280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY18_RS02285	COG0534	Mate efflux family protein
GPY18_RS02295	COG1653	transport
GPY18_RS02300	COG3842	ATPase activity
GPY18_RS02305	COG0395	ABC-type sugar transport system, permease component
GPY18_RS02310	COG1175	transmembrane transport
GPY18_RS02330	COG0800	Aldolase
GPY18_RS02335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY18_RS02350	COG1917	Cupin 2, conserved barrel domain protein
GPY18_RS02360	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS02365	COG1414	Transcriptional regulator
GPY18_RS02370	COG0517	IMP dehydrogenase activity
GPY18_RS02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY18_RS02400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS02440	COG3842	ATPase activity
GPY18_RS02480	COG1349	DNA-binding transcription factor activity
GPY18_RS02500	COG2354	Protein conserved in bacteria
GPY18_RS02505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY18_RS02510	COG0418	dihydroorotase activity
GPY18_RS02515	COG0633	Ferredoxin
GPY18_RS02515	COG3217	Mosc domain protein beta barrel domain protein
GPY18_RS02545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY18_RS02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY18_RS02560	COG0848	biopolymer transport protein
GPY18_RS02565	COG0811	peptide transport
GPY18_RS02570	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY18_RS02575	COG3721	Heme iron utilization protein
GPY18_RS02580	COG0748	coenzyme F420 binding
GPY18_RS02590	COG0531	amino acid
GPY18_RS02595	COG1522	sequence-specific DNA binding
GPY18_RS02625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY18_RS02630	COG2200	EAL domain
GPY18_RS02655	COG5002	protein histidine kinase activity
GPY18_RS02655	COG2205	protein histidine kinase activity
GPY18_RS02655	COG0784	Response regulator, receiver
GPY18_RS02660	COG5001	Diguanylate cyclase
GPY18_RS02660	COG3300	MHYT domain
GPY18_RS02675	COG1765	OsmC-like protein
GPY18_RS02685	COG2171	N-acyltransferase activity
GPY18_RS02710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY18_RS02720	COG1022	Amp-dependent synthetase and ligase
GPY18_RS02740	COG0745	RESPONSE REGULATOR receiver
GPY18_RS02745	COG0642	Histidine kinase
GPY18_RS02755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY18_RS02760	COG3186	Phenylalanine-4-hydroxylase
GPY18_RS02765	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY18_RS02770	COG0534	Mate efflux family protein
GPY18_RS02780	COG0861	Integral membrane protein TerC family
GPY18_RS02790	COG0456	acetyltransferase
GPY18_RS02795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY18_RS02800	COG0662	Cupin 2, conserved barrel domain protein
GPY18_RS02805	COG0527	aspartate kinase activity
GPY18_RS02810	COG0561	phosphatase activity
GPY18_RS02820	COG0583	DNA-binding transcription factor activity
GPY18_RS02830	COG0784	Response regulator, receiver
GPY18_RS02830	COG3437	response regulator, receiver
GPY18_RS02840	COG0113	porphobilinogen synthase activity
GPY18_RS02850	COG0459	protein refolding
GPY18_RS02855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY18_RS02860	COG2239	Acts as a magnesium transporter
GPY18_RS02880	COG2113	Glycine betaine
GPY18_RS02885	COG4176	ABC-type proline glycine betaine transport system permease component
GPY18_RS02890	COG4175	Glycine betaine
GPY18_RS02900	COG1166	arginine decarboxylase activity
GPY18_RS02910	COG1522	sequence-specific DNA binding
GPY18_RS02925	COG0765	amino acid transport
GPY18_RS02935	COG1686	Belongs to the peptidase S11 family
GPY18_RS02950	COG1566	PFAM secretion protein HlyD family protein
GPY18_RS02960	COG3338	carbonate dehydratase activity
GPY18_RS02995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY18_RS03005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY18_RS03015	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS03020	COG0513	Belongs to the DEAD box helicase family
GPY18_RS03030	COG2205	protein histidine kinase activity
GPY18_RS03035	COG0840	transmembrane signaling receptor activity
GPY18_RS03050	COG2985	domain, Protein
GPY18_RS03060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY18_RS03080	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS03125	COG3122	Protein conserved in bacteria
GPY18_RS03145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY18_RS03145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY18_RS03150	COG0509	glycine decarboxylation via glycine cleavage system
GPY18_RS03165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY18_RS03175	COG3706	GGDEF domain
GPY18_RS03180	COG5001	Diguanylate cyclase
GPY18_RS03185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY18_RS03200	COG0546	phosphoglycolate phosphatase activity
GPY18_RS03220	COG0484	heat shock protein binding
GPY18_RS03230	COG5001	Diguanylate cyclase
GPY18_RS03230	COG1716	ATPase activity
GPY18_RS03235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY18_RS03245	COG4181	ATPase activity
GPY18_RS03250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY18_RS03260	COG1984	allophanate hydrolase subunit 2
GPY18_RS03270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY18_RS03275	COG5002	protein histidine kinase activity
GPY18_RS03275	COG3447	MASE1 domain protein
GPY18_RS03275	COG5001	Diguanylate cyclase
GPY18_RS03280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY18_RS03285	COG0840	transmembrane signaling receptor activity
GPY18_RS03290	COG0814	amino acid
GPY18_RS03295	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY18_RS03300	COG0513	Belongs to the DEAD box helicase family
GPY18_RS03305	COG1309	transcriptional regulator
GPY18_RS03315	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY18_RS03330	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY18_RS03370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY18_RS03380	COG0463	Glycosyl transferase, family 2
GPY18_RS03390	COG0583	DNA-binding transcription factor activity
GPY18_RS03395	COG0697	spore germination
GPY18_RS03400	COG2207	Transcriptional regulator
GPY18_RS03400	COG1917	Cupin 2, conserved barrel domain protein
GPY18_RS03425	COG0330	HflC and HflK could
GPY18_RS03435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPY18_RS03450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY18_RS03455	COG0583	DNA-binding transcription factor activity
GPY18_RS03460	COG3781	membrane
GPY18_RS03465	COG0243	molybdopterin cofactor binding
GPY18_RS03470	COG1271	oxidase subunit
GPY18_RS03475	COG1294	oxidase, subunit
GPY18_RS03480	COG0800	Aldolase
GPY18_RS03485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY18_RS03490	COG1904	glucuronate isomerase
GPY18_RS03495	COG0246	Mannitol dehydrogenase
GPY18_RS03510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY18_RS03520	COG2186	Transcriptional regulator
GPY18_RS03540	COG1070	Carbohydrate kinase
GPY18_RS03550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY18_RS03565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY18_RS03575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY18_RS03605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY18_RS03635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY18_RS03640	COG2146	nitrite reductase [NAD(P)H] activity
GPY18_RS03675	COG2814	Major facilitator Superfamily
GPY18_RS03680	COG3118	belongs to the thioredoxin family
GPY18_RS03685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY18_RS03700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY18_RS03710	COG1596	polysaccharide export
GPY18_RS03735	COG0438	transferase activity, transferring glycosyl groups
GPY18_RS03740	COG0297	glycogen (starch) synthase activity
GPY18_RS03740	COG0438	transferase activity, transferring glycosyl groups
GPY18_RS03755	COG0247	lactate metabolic process
GPY18_RS03760	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY18_RS03765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY18_RS03770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY18_RS03775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY18_RS03825	COG4974	Belongs to the 'phage' integrase family
GPY18_RS03845	COG2827	Endonuclease containing a URI domain
GPY18_RS03855	COG1879	ABC-type sugar transport system periplasmic component
GPY18_RS03860	COG5002	protein histidine kinase activity
GPY18_RS03860	COG0784	Response regulator, receiver
GPY18_RS03880	COG1492	cobalamin metabolic process
GPY18_RS03885	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY18_RS03890	COG4149	molybdate abc transporter
GPY18_RS03895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY18_RS03910	COG1289	transmembrane transporter activity
GPY18_RS03960	COG0210	DNA helicase
GPY18_RS03965	COG1335	isochorismatase
GPY18_RS03970	COG1803	Methylglyoxal synthase
GPY18_RS03975	COG1879	ABC-type sugar transport system periplasmic component
GPY18_RS03980	COG2205	protein histidine kinase activity
GPY18_RS03980	COG2198	Histidine kinase
GPY18_RS03980	COG0784	Response regulator, receiver
GPY18_RS03985	COG0469	pyruvate kinase activity
GPY18_RS03990	COG2271	Major facilitator Superfamily
GPY18_RS03995	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY18_RS04015	COG1979	alcohol dehydrogenase
GPY18_RS04020	COG2207	Transcriptional regulator
GPY18_RS04035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY18_RS04040	COG3706	GGDEF domain
GPY18_RS04060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY18_RS04065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY18_RS04075	COG0183	Belongs to the thiolase family
GPY18_RS04115	COG0243	molybdopterin cofactor binding
GPY18_RS04130	COG3850	Histidine kinase
GPY18_RS04135	COG2197	response regulator
GPY18_RS04140	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY18_RS04155	COG2814	Major facilitator Superfamily
GPY18_RS04160	COG0840	transmembrane signaling receptor activity
GPY18_RS04165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY18_RS04170	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY18_RS04185	COG0840	transmembrane signaling receptor activity
GPY18_RS04190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY18_RS04205	COG2897	thiosulfate sulfurtransferase activity
GPY18_RS04210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY18_RS04250	COG0302	gtp cyclohydrolase
GPY18_RS04255	COG0531	amino acid
GPY18_RS04265	COG4303	Ethanolamine ammonia lyase large subunit
GPY18_RS04270	COG2207	Transcriptional regulator
GPY18_RS04275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY18_RS04275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY18_RS04280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY18_RS04285	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY18_RS04295	COG1011	Hydrolase
GPY18_RS04300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY18_RS04310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY18_RS04320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY18_RS04330	COG3842	ATPase activity
GPY18_RS04350	COG2866	Carboxypeptidase
GPY18_RS04375	COG4166	transmembrane transport
GPY18_RS04380	COG4174	ABC transporter (Permease)
GPY18_RS04385	COG4239	(ABC) transporter, permease
GPY18_RS04390	COG4172	Belongs to the ABC transporter superfamily
GPY18_RS04395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY18_RS04410	COG0784	Response regulator, receiver
GPY18_RS04410	COG2205	protein histidine kinase activity
GPY18_RS04420	COG3706	GGDEF domain
GPY18_RS04430	COG2501	S4 domain
GPY18_RS04470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY18_RS04495	COG1979	alcohol dehydrogenase
GPY18_RS04500	COG2207	Transcriptional regulator
GPY18_RS04520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GPY18_RS04530	COG0488	(ABC) transporter
GPY18_RS04550	COG2814	Major facilitator Superfamily
GPY18_RS04570	COG3710	Transcriptional regulator
GPY18_RS04600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS04615	COG2233	PERMEase
GPY18_RS04635	COG1953	Uracil, thiamine, allantoin
GPY18_RS04645	COG0765	amino acid transport
GPY18_RS04650	COG0765	amino acid transport
GPY18_RS04680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY18_RS04700	COG0402	S-adenosylhomocysteine deaminase activity
GPY18_RS04705	COG2351	hydroxyisourate hydrolase activity
GPY18_RS04745	COG1129	ABC transporter
GPY18_RS04750	COG1309	transcriptional regulator
GPY18_RS04760	COG3706	GGDEF domain
GPY18_RS04770	COG0745	RESPONSE REGULATOR receiver
GPY18_RS04770	COG3706	GGDEF domain
GPY18_RS04785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY18_RS04790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY18_RS04800	COG0745	RESPONSE REGULATOR receiver
GPY18_RS04875	COG0023	Translation Initiation Factor
GPY18_RS04890	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY18_RS04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY18_RS04900	COG1042	CoA-binding domain protein
GPY18_RS04900	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY18_RS04905	COG0583	DNA-binding transcription factor activity
GPY18_RS04910	COG4771	TonB-dependent receptor
GPY18_RS04910	COG1629	transport
GPY18_RS04930	COG2050	protein possibly involved in aromatic compounds catabolism
GPY18_RS04935	COG0501	Belongs to the peptidase M48B family
GPY18_RS04940	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY18_RS04950	COG0861	Integral membrane protein TerC family
GPY18_RS04955	COG0737	Belongs to the 5'-nucleotidase family
GPY18_RS04960	COG3593	DNA synthesis involved in DNA repair
GPY18_RS04970	COG0583	DNA-binding transcription factor activity
GPY18_RS04975	COG2116	formate transmembrane transporter activity
GPY18_RS04980	COG2353	YceI-like domain
GPY18_RS04985	COG3038	cytochrome b561
GPY18_RS05010	COG5001	Diguanylate cyclase
GPY18_RS05020	COG0243	molybdopterin cofactor binding
GPY18_RS05025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY18_RS05030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY18_RS05030	COG0543	2 iron, 2 sulfur cluster binding
GPY18_RS05035	COG5002	protein histidine kinase activity
GPY18_RS05035	COG2205	protein histidine kinase activity
GPY18_RS05035	COG0784	Response regulator, receiver
GPY18_RS05040	COG3437	response regulator, receiver
GPY18_RS05050	COG2207	Transcriptional regulator
GPY18_RS05060	COG0523	cobalamin synthesis protein
GPY18_RS05065	COG0038	chloride channel
GPY18_RS05075	COG0156	8-amino-7-oxononanoate synthase activity
GPY18_RS05080	COG0784	Response regulator, receiver
GPY18_RS05080	COG2205	protein histidine kinase activity
GPY18_RS05085	COG0419	ATPase involved in DNA repair
GPY18_RS05095	COG1609	Transcriptional regulator
GPY18_RS05100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS05100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS05105	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY18_RS05110	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY18_RS05110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS05110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS05115	COG0189	ligase activity
GPY18_RS05115	COG4067	protein conserved in archaea
GPY18_RS05125	COG0602	queuosine metabolic process
GPY18_RS05130	COG1328	CTP reductase activity
GPY18_RS05195	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS05200	COG0745	RESPONSE REGULATOR receiver
GPY18_RS05210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY18_RS05220	COG0583	DNA-binding transcription factor activity
GPY18_RS05235	COG1309	transcriptional regulator
GPY18_RS05240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY18_RS05270	COG1335	isochorismatase
GPY18_RS05275	COG4977	sequence-specific DNA binding
GPY18_RS05280	COG0456	acetyltransferase
GPY18_RS05290	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS05295	COG0494	nUDIX hydrolase
GPY18_RS05305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY18_RS05335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY18_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS05365	COG0454	-acetyltransferase
GPY18_RS05425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY18_RS05430	COG0789	Transcriptional regulator
GPY18_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS05495	COG4628	conserved protein (DUF2132)
GPY18_RS05535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY18_RS05540	COG0513	Belongs to the DEAD box helicase family
GPY18_RS05545	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY18_RS05555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY18_RS05565	COG0583	DNA-binding transcription factor activity
GPY18_RS05580	COG3710	Transcriptional regulator
GPY18_RS05585	COG4232	protein-disulfide reductase activity
GPY18_RS05595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY18_RS05605	COG1252	NADH dehydrogenase
GPY18_RS05615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS05620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS05630	COG2207	Transcriptional regulator
GPY18_RS05635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS05635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS05635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS05645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY18_RS05670	COG1538	Outer membrane efflux protein
GPY18_RS05680	COG1132	(ABC) transporter
GPY18_RS05695	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY18_RS05710	COG0110	maltose O-acetyltransferase activity
GPY18_RS05715	COG3706	GGDEF domain
GPY18_RS05725	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY18_RS05730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY18_RS05750	COG0747	negative chemotaxis
GPY18_RS05755	COG4172	Belongs to the ABC transporter superfamily
GPY18_RS05765	COG3437	response regulator, receiver
GPY18_RS05770	COG2205	protein histidine kinase activity
GPY18_RS05770	COG0784	Response regulator, receiver
GPY18_RS05770	COG2198	Histidine kinase
GPY18_RS05780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY18_RS05805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY18_RS05820	COG2423	ornithine cyclodeaminase activity
GPY18_RS05830	COG4145	pantothenate transmembrane transporter activity
GPY18_RS05835	COG0583	DNA-binding transcription factor activity
GPY18_RS05840	COG0435	Glutathione S-transferase
GPY18_RS05845	COG0400	carboxylic ester hydrolase activity
GPY18_RS05850	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS05865	COG1473	amidohydrolase
GPY18_RS05885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY18_RS05890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY18_RS05895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY18_RS05905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY18_RS05920	COG2721	sulfolactate sulfo-lyase activity
GPY18_RS05975	COG0625	glutathione transferase activity
GPY18_RS05995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY18_RS06005	COG0573	inorganic phosphate transmembrane transporter activity
GPY18_RS06010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY18_RS06030	COG1464	Belongs to the NlpA lipoprotein family
GPY18_RS06035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY18_RS06035	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY18_RS06055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY18_RS06070	COG0653	protein targeting
GPY18_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS06105	COG1024	Enoyl-CoA hydratase
GPY18_RS06110	COG1024	Enoyl-CoA hydratase
GPY18_RS06115	COG1960	acyl-CoA dehydrogenase activity
GPY18_RS06125	COG0183	Belongs to the thiolase family
GPY18_RS06135	COG1960	acyl-CoA dehydrogenase activity
GPY18_RS06140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY18_RS06145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY18_RS06160	COG0450	alkyl hydroperoxide reductase
GPY18_RS06195	COG2207	Transcriptional regulator
GPY18_RS06195	COG1609	Transcriptional regulator
GPY18_RS06200	COG1454	alcohol dehydrogenase
GPY18_RS06205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY18_RS06250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY18_RS06265	COG2207	Transcriptional regulator
GPY18_RS06265	COG3708	Transcriptional regulator
GPY18_RS06270	COG4604	ABC transporter, ATP-binding protein
GPY18_RS06275	COG4605	iron ion homeostasis
GPY18_RS06280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY18_RS06300	COG4412	M6 family metalloprotease domain protein
GPY18_RS06300	COG3291	Pkd domain containing protein
GPY18_RS06305	COG5380	lipid catabolic process
GPY18_RS06310	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY18_RS06320	COG1522	sequence-specific DNA binding
GPY18_RS06340	COG2814	Major facilitator Superfamily
GPY18_RS06350	COG0840	transmembrane signaling receptor activity
GPY18_RS06370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY18_RS06375	COG3279	Response regulator of the LytR AlgR family
GPY18_RS06380	COG3275	phosphorelay sensor kinase activity
GPY18_RS06385	COG4989	oxidoreductase activity
GPY18_RS06400	COG0366	Alpha amylase catalytic
GPY18_RS06405	COG3227	Zinc metalloprotease (Elastase)
GPY18_RS06410	COG3047	cAMP biosynthetic process
GPY18_RS06415	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY18_RS06430	COG0251	oxidation-reduction process
GPY18_RS06440	COG0583	DNA-binding transcription factor activity
GPY18_RS06445	COG2267	carboxylic ester hydrolase activity
GPY18_RS06455	COG1132	(ABC) transporter
GPY18_RS06460	COG1132	(ABC) transporter
GPY18_RS06470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY18_RS06475	COG2246	polysaccharide biosynthetic process
GPY18_RS06485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY18_RS06495	COG0242	peptide deformylase activity
GPY18_RS06505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS06510	COG2084	Dehydrogenase
GPY18_RS06520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY18_RS06525	COG0583	DNA-binding transcription factor activity
GPY18_RS06555	COG1063	alcohol dehydrogenase
GPY18_RS06560	COG0156	8-amino-7-oxononanoate synthase activity
GPY18_RS06565	COG1012	belongs to the aldehyde dehydrogenase family
GPY18_RS06570	COG3284	Transcriptional regulator
GPY18_RS06580	COG0346	lactoylglutathione lyase activity
GPY18_RS06600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY18_RS06610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY18_RS06615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY18_RS06620	COG0363	glucosamine-6-phosphate deaminase activity
GPY18_RS06625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY18_RS06640	COG0583	DNA-binding transcription factor activity
GPY18_RS06655	COG1410	methionine synthase
GPY18_RS06655	COG0646	methionine synthase
GPY18_RS06660	COG0531	amino acid
GPY18_RS06675	COG1473	amidohydrolase
GPY18_RS06680	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY18_RS06685	COG1929	Belongs to the glycerate kinase type-1 family
GPY18_RS06690	COG2610	gluconate transmembrane transporter activity
GPY18_RS06695	COG3835	regulator
GPY18_RS06700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY18_RS06705	COG4533	DNA binding
GPY18_RS06720	COG0840	transmembrane signaling receptor activity
GPY18_RS06775	COG4964	Belongs to the GSP D family
GPY18_RS06815	COG0798	PFAM Bile acid sodium symporter
GPY18_RS06830	COG0326	Molecular chaperone. Has ATPase activity
GPY18_RS06850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY18_RS06855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY18_RS06855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY18_RS06885	COG3036	rescue of stalled ribosome
GPY18_RS06890	COG1278	Cold shock
GPY18_RS06895	COG4681	YaeQ
GPY18_RS06900	COG3706	GGDEF domain
GPY18_RS06905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY18_RS06905	COG1017	nitric oxide dioxygenase activity
GPY18_RS06910	COG3604	Transcriptional regulator
GPY18_RS06920	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY18_RS06935	COG0564	pseudouridine synthase activity
GPY18_RS06945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY18_RS06950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY18_RS06955	COG4136	ATPase activity
GPY18_RS06960	COG4135	transport system, permease component
GPY18_RS06965	COG4134	Bacterial extracellular solute-binding protein
GPY18_RS06975	COG3313	Fe-S protein
GPY18_RS06985	COG0842	Transport permease protein
GPY18_RS06990	COG1131	(ABC) transporter
GPY18_RS07000	COG0814	amino acid
GPY18_RS07015	COG3706	GGDEF domain
GPY18_RS07020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY18_RS07030	COG1278	Cold shock
GPY18_RS07050	COG3119	arylsulfatase activity
GPY18_RS07055	COG0641	radical SAM
GPY18_RS07060	COG0714	Associated with various cellular activities
GPY18_RS07095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY18_RS07100	COG2205	protein histidine kinase activity
GPY18_RS07105	COG0745	RESPONSE REGULATOR receiver
GPY18_RS07115	COG1061	Type III restriction enzyme res subunit
GPY18_RS07125	COG2814	Major facilitator Superfamily
GPY18_RS07135	COG0702	epimerase
GPY18_RS07140	COG0534	Mate efflux family protein
GPY18_RS07145	COG4181	ATPase activity
GPY18_RS07160	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY18_RS07210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY18_RS07220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY18_RS07225	COG3265	gluconokinase activity
GPY18_RS07230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY18_RS07260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY18_RS07280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY18_RS07305	COG2989	Protein conserved in bacteria
GPY18_RS07310	COG3108	Peptidase M15
GPY18_RS07315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY18_RS07330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY18_RS07350	COG2197	response regulator
GPY18_RS07355	COG1846	Transcriptional regulator
GPY18_RS07360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY18_RS07365	COG0840	transmembrane signaling receptor activity
GPY18_RS07370	COG2176	DNA-directed DNA polymerase activity
GPY18_RS07375	COG0517	IMP dehydrogenase activity
GPY18_RS07385	COG1448	Aminotransferase
GPY18_RS07400	COG0017	Asparaginyl-tRNA synthetase
GPY18_RS07405	COG0840	transmembrane signaling receptor activity
GPY18_RS07410	COG0720	synthase
GPY18_RS07415	COG1538	Outer membrane efflux protein
GPY18_RS07420	COG1136	(ABC) transporter
GPY18_RS07420	COG0577	efflux transmembrane transporter activity
GPY18_RS07425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY18_RS07430	COG1760	l-serine dehydratase
GPY18_RS07435	COG0814	amino acid
GPY18_RS07440	COG0494	nUDIX hydrolase
GPY18_RS07455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY18_RS07470	COG3106	COG3106 Predicted ATPase
GPY18_RS07475	COG3768	UPF0283 membrane protein
GPY18_RS07480	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY18_RS07485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY18_RS07505	COG0471	metal ion transport
GPY18_RS07510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY18_RS07510	COG4191	Histidine kinase
GPY18_RS07520	COG0583	DNA-binding transcription factor activity
GPY18_RS07525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY18_RS07530	COG0778	Nitroreductase
GPY18_RS07535	COG2991	Protein conserved in bacteria
GPY18_RS07545	COG3250	beta-galactosidase activity
GPY18_RS07555	COG1129	ABC transporter
GPY18_RS07595	COG2169	Transcriptional regulator
GPY18_RS07595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY18_RS07605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY18_RS07610	COG0372	Belongs to the citrate synthase family
GPY18_RS07615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPY18_RS07620	COG2828	Protein conserved in bacteria
GPY18_RS07635	COG1566	PFAM secretion protein HlyD family protein
GPY18_RS07640	COG2814	Major facilitator Superfamily
GPY18_RS07655	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY18_RS07660	COG2200	EAL domain
GPY18_RS07670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY18_RS07680	COG0625	glutathione transferase activity
GPY18_RS07700	COG2731	YhcH YjgK YiaL family protein
GPY18_RS07710	COG0584	glycerophosphoryl diester phosphodiesterase
GPY18_RS07715	COG1349	DNA-binding transcription factor activity
GPY18_RS07720	COG3842	ATPase activity
GPY18_RS07725	COG0395	ABC-type sugar transport system, permease component
GPY18_RS07745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY18_RS07750	COG3040	lipid binding
GPY18_RS07760	COG0811	peptide transport
GPY18_RS07765	COG0811	peptide transport
GPY18_RS07770	COG0848	biopolymer transport protein
GPY18_RS07790	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY18_RS07795	COG1793	dna ligase
GPY18_RS07810	COG0307	riboflavin synthase, alpha
GPY18_RS07830	COG0791	NLP P60 protein
GPY18_RS07835	COG0840	transmembrane signaling receptor activity
GPY18_RS07850	COG1940	carbohydrate kinase activity
GPY18_RS07860	COG0303	'Molybdopterin
GPY18_RS07865	COG0746	molybdenum cofactor guanylyltransferase activity
GPY18_RS07870	COG3842	ATPase activity
GPY18_RS07875	COG4662	Binding-protein-dependent transport system inner membrane component
GPY18_RS07885	COG2204	response regulator
GPY18_RS07890	COG3852	Histidine kinase
GPY18_RS07905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY18_RS07925	COG3381	protein complex oligomerization
GPY18_RS07940	COG0437	4 iron, 4 sulfur cluster binding
GPY18_RS07955	COG0004	ammonium transporteR
GPY18_RS07960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY18_RS07965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY18_RS07970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY18_RS07975	COG1177	transmembrane transport
GPY18_RS07980	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY18_RS07985	COG3842	ATPase activity
GPY18_RS08010	COG0589	response to stress
GPY18_RS08015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY18_RS08030	COG2217	Heavy metal translocating P-type atpase
GPY18_RS08040	COG2010	Cytochrome c
GPY18_RS08055	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY18_RS08160	COG3120	sequence-specific DNA binding
GPY18_RS08165	COG1067	ATP-dependent peptidase activity
GPY18_RS08170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY18_RS08195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY18_RS08195	COG0116	Belongs to the methyltransferase superfamily
GPY18_RS08205	COG0167	dihydroorotate dehydrogenase activity
GPY18_RS08220	COG0308	aminopeptidase N
GPY18_RS08245	COG1956	GAF domain-containing protein
GPY18_RS08250	COG1132	(ABC) transporter
GPY18_RS08255	COG2995	paraquat-inducible protein a
GPY18_RS08260	COG3008	intermembrane lipid transfer
GPY18_RS08265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY18_RS08265	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY18_RS08270	COG2996	Protein conserved in bacteria
GPY18_RS08285	COG0574	Belongs to the PEP-utilizing enzyme family
GPY18_RS08285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY18_RS08290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY18_RS08315	COG1115	amino acid carrier protein
GPY18_RS08340	COG3501	Rhs element vgr protein
GPY18_RS08350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY18_RS08360	COG1643	Atp-dependent helicase
GPY18_RS08365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY18_RS08375	COG3005	denitrification pathway
GPY18_RS08400	COG3706	GGDEF domain
GPY18_RS08415	COG0443	Heat shock 70 kDa protein
GPY18_RS08420	COG3706	GGDEF domain
GPY18_RS08430	COG3706	GGDEF domain
GPY18_RS08445	COG2999	glutathione oxidoreductase activity
GPY18_RS08465	COG3706	GGDEF domain
GPY18_RS08465	COG0745	RESPONSE REGULATOR receiver
GPY18_RS08475	COG0243	molybdopterin cofactor binding
GPY18_RS08480	COG3005	denitrification pathway
GPY18_RS08490	COG0602	queuosine metabolic process
GPY18_RS08495	COG0561	phosphatase activity
GPY18_RS08505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY18_RS08510	COG4597	amino acid ABC transporter
GPY18_RS08515	COG0765	amino acid transport
GPY18_RS08520	COG1126	abc transporter atp-binding protein
GPY18_RS08525	COG0670	Belongs to the BI1 family
GPY18_RS08530	COG2920	part of a sulfur-relay system
GPY18_RS08535	COG1254	Belongs to the acylphosphatase family
GPY18_RS08540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY18_RS08545	COG3391	amine dehydrogenase activity
GPY18_RS08565	COG2010	Cytochrome c
GPY18_RS08585	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY18_RS08590	COG5002	protein histidine kinase activity
GPY18_RS08595	COG0745	RESPONSE REGULATOR receiver
GPY18_RS08610	COG0668	transmembrane transport
GPY18_RS08645	COG1278	Cold shock
GPY18_RS08680	COG4974	Belongs to the 'phage' integrase family
GPY18_RS08840	COG2207	Transcriptional regulator
GPY18_RS08845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GPY18_RS08850	COG4695	Portal protein
GPY18_RS08890	COG4386	tail sheath protein
GPY18_RS08930	COG3706	GGDEF domain
GPY18_RS08930	COG0745	RESPONSE REGULATOR receiver
GPY18_RS08945	COG0784	Response regulator, receiver
GPY18_RS08945	COG0835	chemotaxis
GPY18_RS08955	COG4565	transcriptional regulatory protein
GPY18_RS08960	COG3290	protein histidine kinase activity
GPY18_RS08975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY18_RS08995	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY18_RS09000	COG3063	Type IV pilus biogenesis stability protein PilW
GPY18_RS09015	COG1451	nucleotide metabolic process
GPY18_RS09025	COG0583	DNA-binding transcription factor activity
GPY18_RS09080	COG4139	cobalamin transport
GPY18_RS09085	COG2988	succinylglutamate desuccinylase activity
GPY18_RS09100	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY18_RS09105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY18_RS09110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPY18_RS09115	COG0702	epimerase
GPY18_RS09130	COG2925	Exonuclease
GPY18_RS09140	COG1346	cytolysis
GPY18_RS09145	COG0295	cytidine deaminase activity
GPY18_RS09150	COG5001	Diguanylate cyclase
GPY18_RS09170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY18_RS09180	COG0500	methyltransferase
GPY18_RS09190	COG0776	regulation of translation
GPY18_RS09195	COG0072	phenylalanine-tRNA ligase activity
GPY18_RS09195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY18_RS09200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY18_RS09215	COG0745	RESPONSE REGULATOR receiver
GPY18_RS09215	COG3706	GGDEF domain
GPY18_RS09220	COG2133	pyrroloquinoline quinone binding
GPY18_RS09250	COG0322	excinuclease ABC activity
GPY18_RS09255	COG2197	response regulator
GPY18_RS09260	COG0417	DNA replication proofreading
GPY18_RS09265	COG5001	Diguanylate cyclase
GPY18_RS09275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY18_RS09295	COG1228	amidohydrolase
GPY18_RS09300	COG0010	Belongs to the arginase family
GPY18_RS09310	COG2986	histidine ammonia-lyase
GPY18_RS09330	COG0277	FAD linked oxidase domain protein
GPY18_RS09330	COG0247	lactate metabolic process
GPY18_RS09345	COG2885	chlorophyll binding
GPY18_RS09370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY18_RS09380	COG2957	Belongs to the agmatine deiminase family
GPY18_RS09390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY18_RS09395	COG1012	belongs to the aldehyde dehydrogenase family
GPY18_RS09400	COG1396	sequence-specific DNA binding
GPY18_RS09400	COG1917	Cupin 2, conserved barrel domain protein
GPY18_RS09405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY18_RS09410	COG0174	glutamine synthetase
GPY18_RS09415	COG1757	Na H antiporter
GPY18_RS09425	COG1643	Atp-dependent helicase
GPY18_RS09430	COG0281	malic enzyme
GPY18_RS09450	COG0583	DNA-binding transcription factor activity
GPY18_RS09465	COG0640	Transcriptional regulator
GPY18_RS09490	COG2949	membrane
GPY18_RS09500	COG1414	Transcriptional regulator
GPY18_RS09505	COG1414	Transcriptional regulator
GPY18_RS09515	COG1454	alcohol dehydrogenase
GPY18_RS09520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY18_RS09540	COG0492	ferredoxin-NADP+ reductase activity
GPY18_RS09545	COG4988	ABC transporter
GPY18_RS09550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY18_RS09570	COG1187	pseudouridine synthase activity
GPY18_RS09575	COG0009	L-threonylcarbamoyladenylate synthase
GPY18_RS09605	COG0613	PHP domain protein
GPY18_RS09615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY18_RS09620	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY18_RS09625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY18_RS09630	COG0135	phosphoribosylanthranilate isomerase activity
GPY18_RS09630	COG0134	indole-3-glycerol-phosphate synthase activity
GPY18_RS09635	COG0133	tryptophan synthase activity
GPY18_RS09645	COG1301	dicarboxylic acid transport
GPY18_RS09660	COG1607	acyl-coa hydrolase
GPY18_RS09665	COG2350	Protein conserved in bacteria
GPY18_RS09675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY18_RS09680	COG0583	DNA-binding transcription factor activity
GPY18_RS09695	COG0612	Peptidase, M16
GPY18_RS09715	COG0625	glutathione transferase activity
GPY18_RS09725	COG2200	EAL domain
GPY18_RS09725	COG2771	luxR family
GPY18_RS09730	COG0840	transmembrane signaling receptor activity
GPY18_RS09745	COG1794	racemase activity, acting on amino acids and derivatives
GPY18_RS09750	COG0346	lactoylglutathione lyase activity
GPY18_RS09755	COG5002	protein histidine kinase activity
GPY18_RS09760	COG0745	RESPONSE REGULATOR receiver
GPY18_RS09780	COG0488	(ABC) transporter
GPY18_RS09785	COG1032	radical SAM domain protein
GPY18_RS09790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY18_RS09800	COG3852	Histidine kinase
GPY18_RS09815	COG3070	regulator of competence-specific genes
GPY18_RS09825	COG2431	L-lysine efflux transmembrane transporter activity
GPY18_RS09835	COG0076	glutamate decarboxylase activity
GPY18_RS09840	COG1737	Transcriptional regulator
GPY18_RS09845	COG1979	alcohol dehydrogenase
GPY18_RS09850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY18_RS09860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY18_RS09865	COG1960	acyl-CoA dehydrogenase activity
GPY18_RS09885	COG1012	belongs to the aldehyde dehydrogenase family
GPY18_RS09900	COG5002	protein histidine kinase activity
GPY18_RS09900	COG0784	Response regulator, receiver
GPY18_RS09910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY18_RS09915	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY18_RS09920	COG2885	chlorophyll binding
GPY18_RS09940	COG0811	peptide transport
GPY18_RS09945	COG0824	Thioesterase
GPY18_RS09955	COG4890	Cyd operon protein YbgT
GPY18_RS09960	COG1294	oxidase, subunit
GPY18_RS09965	COG1271	oxidase subunit
GPY18_RS09970	COG2255	four-way junction helicase activity
GPY18_RS09975	COG0632	four-way junction helicase activity
GPY18_RS09980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY18_RS09985	COG0215	cysteine-tRNA ligase activity
GPY18_RS09990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY18_RS09995	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY18_RS10000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY18_RS10005	COG3012	SEC-C Motif Domain Protein
GPY18_RS10015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY18_RS10020	COG1199	ATP-dependent helicase activity
GPY18_RS10025	COG3923	Primosomal replication protein n
GPY18_RS10035	COG0840	transmembrane signaling receptor activity
GPY18_RS10040	COG0708	Exodeoxyribonuclease III
GPY18_RS10045	COG4160	amino acid transport
GPY18_RS10050	COG4215	(ABC) transporter
GPY18_RS10070	COG1882	Formate acetyltransferase
GPY18_RS10085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY18_RS10105	COG2766	serine protein kinase
GPY18_RS10110	COG2718	Belongs to the UPF0229 family
GPY18_RS10115	COG2719	SpoVR family
GPY18_RS10120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY18_RS10135	COG1132	(ABC) transporter
GPY18_RS10140	COG0658	competence protein
GPY18_RS10140	COG2333	competence protein COMEC
GPY18_RS10150	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY18_RS10155	COG1136	(ABC) transporter
GPY18_RS10160	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY18_RS10170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY18_RS10185	COG1252	NADH dehydrogenase
GPY18_RS10215	COG0537	adenosine 5'-monophosphoramidase activity
GPY18_RS10230	COG2186	Transcriptional regulator
GPY18_RS10235	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY18_RS10240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY18_RS10245	COG1674	ftsk spoiiie
GPY18_RS10250	COG1522	sequence-specific DNA binding
GPY18_RS10255	COG0686	Belongs to the AlaDH PNT family
GPY18_RS10265	COG0583	DNA-binding transcription factor activity
GPY18_RS10285	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY18_RS10290	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY18_RS10300	COG0539	negative regulation of cytoplasmic translation
GPY18_RS10305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY18_RS10310	COG1555	photosystem II stabilization
GPY18_RS10315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY18_RS10320	COG0776	regulation of translation
GPY18_RS10325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY18_RS10330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY18_RS10340	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY18_RS10345	COG4191	Histidine kinase
GPY18_RS10350	COG2204	response regulator
GPY18_RS10360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY18_RS10365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY18_RS10385	COG0745	RESPONSE REGULATOR receiver
GPY18_RS10390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY18_RS10395	COG1760	l-serine dehydratase
GPY18_RS10415	COG5001	Diguanylate cyclase
GPY18_RS10415	COG1716	ATPase activity
GPY18_RS10425	COG4589	Belongs to the CDS family
GPY18_RS10460	COG2197	response regulator
GPY18_RS10465	COG3851	Histidine kinase
GPY18_RS10470	COG2271	Major facilitator Superfamily
GPY18_RS10475	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY18_RS10485	COG3842	ATPase activity
GPY18_RS10495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY18_RS10500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY18_RS10510	COG2951	lytic endotransglycosylase activity
GPY18_RS10515	COG3100	YcgL domain-containing protein
GPY18_RS10525	COG2894	cell division
GPY18_RS10530	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY18_RS10540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY18_RS10545	COG0318	PFAM AMP-dependent synthetase and ligase
GPY18_RS10565	COG1214	PFAM Peptidase M22, glycoprotease
GPY18_RS10570	COG1199	ATP-dependent helicase activity
GPY18_RS10580	COG0788	formyltetrahydrofolate deformylase activity
GPY18_RS10585	COG1902	pentaerythritol trinitrate reductase activity
GPY18_RS10585	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY18_RS10590	COG0616	signal peptide processing
GPY18_RS10595	COG0252	asparaginase activity
GPY18_RS10600	COG3139	Protein of unknown function (DUF1315)
GPY18_RS10610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY18_RS10615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY18_RS10625	COG2226	methyltransferase
GPY18_RS10650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY18_RS10655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY18_RS10660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY18_RS10670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY18_RS10675	COG2832	Protein of unknown function (DUF454)
GPY18_RS10685	COG0745	RESPONSE REGULATOR receiver
GPY18_RS10690	COG0583	DNA-binding transcription factor activity
GPY18_RS10695	COG0778	Nitroreductase
GPY18_RS10700	COG1024	Enoyl-CoA hydratase
GPY18_RS10700	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY18_RS10705	COG0183	Belongs to the thiolase family
GPY18_RS10720	COG2067	long-chain fatty acid transport protein
GPY18_RS10730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY18_RS10745	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY18_RS10750	COG2982	Protein involved in outer membrane biogenesis
GPY18_RS10755	COG0572	uridine kinase
GPY18_RS10760	COG0489	protein tyrosine kinase activity
GPY18_RS10765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY18_RS10765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY18_RS10775	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY18_RS10785	COG0517	IMP dehydrogenase activity
GPY18_RS10785	COG0516	GMP reductase activity
GPY18_RS10790	COG3706	GGDEF domain
GPY18_RS10795	COG0314	molybdopterin synthase activity
GPY18_RS10800	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY18_RS10805	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY18_RS10810	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY18_RS10815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY18_RS10820	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY18_RS10825	COG2198	Histidine kinase
GPY18_RS10830	COG2204	response regulator
GPY18_RS10845	COG4657	Part of a membrane complex involved in electron transport
GPY18_RS10850	COG2878	Part of a membrane complex involved in electron transport
GPY18_RS10855	COG4656	Part of a membrane complex involved in electron transport
GPY18_RS10860	COG4658	electron transport chain
GPY18_RS10870	COG4660	Part of a membrane complex involved in electron transport
GPY18_RS10875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY18_RS10880	COG0346	lactoylglutathione lyase activity
GPY18_RS10895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY18_RS10900	COG2056	Na+-H+ antiporter family
GPY18_RS10905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY18_RS10910	COG1286	toxin biosynthetic process
GPY18_RS10915	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY18_RS10920	COG0285	dihydrofolate synthase activity
GPY18_RS10930	COG0101	tRNA pseudouridine synthase activity
GPY18_RS10940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY18_RS10945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY18_RS10945	COG2190	(PTS) system
GPY18_RS10945	COG1263	PTS System
GPY18_RS10950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY18_RS10955	COG1940	carbohydrate kinase activity
GPY18_RS10955	COG1846	Transcriptional regulator
GPY18_RS10960	COG4651	solute:proton antiporter activity
GPY18_RS10960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY18_RS10965	COG0367	asparagine synthase
GPY18_RS10975	COG3104	oligopeptide transport
GPY18_RS10980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY18_RS10990	COG0326	Molecular chaperone. Has ATPase activity
GPY18_RS10995	COG3710	Transcriptional regulator
GPY18_RS11010	COG0622	Phosphoesterase
GPY18_RS11035	COG1090	epimerase
GPY18_RS11040	COG0300	oxidoreductase activity
GPY18_RS11050	COG3118	belongs to the thioredoxin family
GPY18_RS11055	COG0330	HflC and HflK could
GPY18_RS11065	COG0789	Transcriptional regulator
GPY18_RS11080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY18_RS11085	COG3115	cell septum assembly
GPY18_RS11090	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY18_RS11095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY18_RS11105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS11115	COG2190	(PTS) system
GPY18_RS11120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY18_RS11125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY18_RS11130	COG1702	phosphate starvation-inducible protein PhoH
GPY18_RS11135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY18_RS11140	COG4535	Mg2 and Co2 transporter CorC
GPY18_RS11145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY18_RS11150	COG2888	peptidyl-tyrosine sulfation
GPY18_RS11160	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY18_RS11165	COG1466	dna polymerase III delta subunit
GPY18_RS11170	COG0799	negative regulation of ribosome biogenesis
GPY18_RS11175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY18_RS11180	COG0768	penicillin binding
GPY18_RS11185	COG0772	Belongs to the SEDS family
GPY18_RS11190	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY18_RS11195	COG1686	Belongs to the peptidase S11 family
GPY18_RS11200	COG2921	Belongs to the UPF0250 family
GPY18_RS11210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY18_RS11220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY18_RS11230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY18_RS11235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY18_RS11260	COG0366	Alpha amylase catalytic
GPY18_RS11265	COG1263	PTS System
GPY18_RS11265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY18_RS11280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY18_RS11285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY18_RS11290	COG2011	ABC-type metal ion transport system permease component
GPY18_RS11295	COG1464	Belongs to the NlpA lipoprotein family
GPY18_RS11300	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY18_RS11310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY18_RS11310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY18_RS11320	COG3706	GGDEF domain
GPY18_RS11320	COG0745	RESPONSE REGULATOR receiver
GPY18_RS11325	COG1611	Belongs to the LOG family
GPY18_RS11330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY18_RS11340	COG2363	Small membrane protein
GPY18_RS11350	COG0583	DNA-binding transcription factor activity
GPY18_RS11355	COG0301	tRNA thio-modification
GPY18_RS11355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY18_RS11365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY18_RS11375	COG0142	geranyltranstransferase activity
GPY18_RS11380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY18_RS11385	COG0564	pseudouridine synthase activity
GPY18_RS11390	COG3098	single-species biofilm formation
GPY18_RS11415	COG1671	Belongs to the UPF0178 family
GPY18_RS11420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY18_RS11425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY18_RS11430	COG0254	rRNA binding
GPY18_RS11435	COG1720	tRNA m6t6A37 methyltransferase activity
GPY18_RS11440	COG0442	prolyl-tRNA aminoacylation
GPY18_RS11465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY18_RS11470	COG0590	tRNA wobble adenosine to inosine editing
GPY18_RS11475	COG0583	DNA-binding transcription factor activity
GPY18_RS11480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY18_RS11485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPY18_RS11490	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY18_RS11515	COG4969	Belongs to the N-Me-Phe pilin family
GPY18_RS11520	COG0484	heat shock protein binding
GPY18_RS11525	COG0443	Heat shock 70 kDa protein
GPY18_RS11535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY18_RS11540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY18_RS11545	COG0497	DNA recombination
GPY18_RS11550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY18_RS11555	COG2914	Belongs to the UPF0125 (RnfH) family
GPY18_RS11560	COG2867	negative regulation of translational initiation
GPY18_RS11565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY18_RS11595	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GPY18_RS11620	COG0583	DNA-binding transcription factor activity
GPY18_RS11625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY18_RS11630	COG1115	amino acid carrier protein
GPY18_RS11640	COG1473	amidohydrolase
GPY18_RS11655	COG1584	GPR1 FUN34 yaaH family protein
GPY18_RS11665	COG0519	Catalyzes the synthesis of GMP from XMP
GPY18_RS11665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY18_RS11670	COG0516	GMP reductase activity
GPY18_RS11670	COG0517	IMP dehydrogenase activity
GPY18_RS11675	COG1570	exodeoxyribonuclease VII activity
GPY18_RS11690	COG1160	GTP binding
GPY18_RS11695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY18_RS11700	COG2976	Protein conserved in bacteria
GPY18_RS11705	COG0124	histidyl-tRNA synthetase
GPY18_RS11710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY18_RS11715	COG1426	Protein conserved in bacteria
GPY18_RS11730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY18_RS11735	COG2975	iron-sulfur cluster assembly
GPY18_RS11740	COG0633	Ferredoxin
GPY18_RS11745	COG0443	Heat shock 70 kDa protein
GPY18_RS11760	COG0822	iron-sulfur transferase activity
GPY18_RS11765	COG1104	cysteine desulfurase activity
GPY18_RS11770	COG1959	2 iron, 2 sulfur cluster binding
GPY18_RS11775	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY18_RS11780	COG0483	inositol monophosphate 1-phosphatase activity
GPY18_RS11785	COG1335	isochorismatase
GPY18_RS11790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY18_RS11795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY18_RS11800	COG1862	Preprotein translocase
GPY18_RS11805	COG0343	queuine tRNA-ribosyltransferase activity
GPY18_RS11810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY18_RS11815	COG0517	IMP dehydrogenase activity
GPY18_RS11825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY18_RS11830	COG0583	DNA-binding transcription factor activity
GPY18_RS11835	COG0450	alkyl hydroperoxide reductase
GPY18_RS11850	COG0704	Plays a role in the regulation of phosphate uptake
GPY18_RS11855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY18_RS11860	COG0581	inorganic phosphate transmembrane transporter activity
GPY18_RS11865	COG0573	inorganic phosphate transmembrane transporter activity
GPY18_RS11870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY18_RS11875	COG0248	Ppx GppA phosphatase
GPY18_RS11885	COG5002	protein histidine kinase activity
GPY18_RS11890	COG0745	RESPONSE REGULATOR receiver
GPY18_RS11895	COG2974	May be involved in recombination
GPY18_RS11905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY18_RS11910	COG0477	Major facilitator Superfamily
GPY18_RS11920	COG1595	DNA-templated transcription, initiation
GPY18_RS11930	COG3248	Nucleoside-binding outer membrane protein
GPY18_RS11935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY18_RS11940	COG0693	protein deglycase activity
GPY18_RS11945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY18_RS11955	COG2166	iron-sulfur cluster assembly
GPY18_RS11960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY18_RS11965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY18_RS11975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY18_RS11975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY18_RS11985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY18_RS11990	COG1074	ATP-dependent DNA helicase activity
GPY18_RS12005	COG0583	DNA-binding transcription factor activity
GPY18_RS12010	COG3141	response to X-ray
GPY18_RS12015	COG2171	N-acyltransferase activity
GPY18_RS12020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY18_RS12035	COG0189	ligase activity
GPY18_RS12035	COG0569	domain protein
GPY18_RS12050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY18_RS12055	COG2017	converts alpha-aldose to the beta-anomer
GPY18_RS12065	COG2059	Chromate
GPY18_RS12070	COG3437	response regulator, receiver
GPY18_RS12070	COG0784	Response regulator, receiver
GPY18_RS12120	COG4964	Belongs to the GSP D family
GPY18_RS12160	COG0583	DNA-binding transcription factor activity
GPY18_RS12175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY18_RS12180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY18_RS12190	COG0560	Phosphoserine phosphatase
GPY18_RS12200	COG0813	purine-nucleoside phosphorylase activity
GPY18_RS12205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY18_RS12210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY18_RS12215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY18_RS12220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY18_RS12245	COG0084	hydrolase, TatD family'
GPY18_RS12255	COG1115	amino acid carrier protein
GPY18_RS12270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY18_RS12290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY18_RS12295	COG0083	homoserine kinase activity
GPY18_RS12310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY18_RS12325	COG0745	RESPONSE REGULATOR receiver
GPY18_RS12335	COG5002	protein histidine kinase activity
GPY18_RS12335	COG0784	Response regulator, receiver
GPY18_RS12335	COG2198	Histidine kinase
GPY18_RS12340	COG5001	Diguanylate cyclase
GPY18_RS12340	COG2203	Gaf domain
GPY18_RS12340	COG3706	GGDEF domain
GPY18_RS12340	COG4251	negative regulation of phosphorylation
GPY18_RS12345	COG1242	4 iron, 4 sulfur cluster binding
GPY18_RS12350	COG0067	glutamate synthase
GPY18_RS12350	COG0069	glutamate synthase activity
GPY18_RS12350	COG0070	glutamate synthase
GPY18_RS12360	COG0067	glutamate synthase
GPY18_RS12360	COG0069	glutamate synthase activity
GPY18_RS12360	COG0070	glutamate synthase
GPY18_RS12365	COG0493	'glutamate synthase
GPY18_RS12385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY18_RS12390	COG2860	membrane
GPY18_RS12410	COG0583	DNA-binding transcription factor activity
GPY18_RS12415	COG0730	response to heat
GPY18_RS12425	COG0505	Belongs to the CarA family
GPY18_RS12435	COG0494	nUDIX hydrolase
GPY18_RS12440	COG0653	protein targeting
GPY18_RS12450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY18_RS12455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY18_RS12460	COG0849	cell division
GPY18_RS12465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY18_RS12470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY18_RS12475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY18_RS12480	COG0772	Belongs to the SEDS family
GPY18_RS12485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY18_RS12490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY18_RS12495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY18_RS12500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY18_RS12505	COG0768	penicillin binding
GPY18_RS12510	COG3116	cell division
GPY18_RS12515	COG0275	rRNA processing
GPY18_RS12525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY18_RS12530	COG3107	peptidoglycan biosynthetic process
GPY18_RS12535	COG0792	nuclease activity
GPY18_RS12540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY18_RS12545	COG2823	Periplasmic or secreted lipoprotein
GPY18_RS12550	COG2969	positive regulation of protein catabolic process
GPY18_RS12555	COG0625	glutathione transferase activity
GPY18_RS12560	COG2857	Cytochrome c1
GPY18_RS12565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY18_RS12570	COG0723	plastoquinol--plastocyanin reductase activity
GPY18_RS12575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY18_RS12580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY18_RS12590	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY18_RS12595	COG3105	Protein conserved in bacteria
GPY18_RS12600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY18_RS12605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY18_RS12610	COG0335	large ribosomal subunit rRNA binding
GPY18_RS12620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY18_RS12630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY18_RS12635	COG4137	Cytochrome C assembly protein
GPY18_RS12640	COG4536	flavin adenine dinucleotide binding
GPY18_RS12645	COG1854	S-ribosylhomocysteine lyase activity
GPY18_RS12660	COG0612	Peptidase, M16
GPY18_RS12665	COG1238	metal cluster binding
GPY18_RS12670	COG1063	alcohol dehydrogenase
GPY18_RS12675	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY18_RS12680	COG0511	ligase activity, forming carbon-carbon bonds
GPY18_RS12680	COG5016	pyruvate
GPY18_RS12685	COG3630	sodium ion export across plasma membrane
GPY18_RS12735	COG0527	aspartate kinase activity
GPY18_RS12740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY18_RS12750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY18_RS12755	COG1546	Belongs to the CinA family
GPY18_RS12760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY18_RS12765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY18_RS12770	COG4942	peptidase
GPY18_RS12770	COG1388	LysM domain
GPY18_RS12780	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY18_RS12785	COG0585	pseudouridine synthase activity
GPY18_RS12795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY18_RS12800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY18_RS12805	COG1968	undecaprenyl-diphosphatase activity
GPY18_RS12810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY18_RS12815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY18_RS12820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY18_RS12825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY18_RS12830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY18_RS12835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY18_RS12840	COG1610	YqeY-like protein
GPY18_RS12850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY18_RS12935	COG0210	DNA helicase
GPY18_RS12945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY18_RS12960	COG2239	Acts as a magnesium transporter
GPY18_RS12975	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY18_RS12980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY18_RS12985	COG1349	DNA-binding transcription factor activity
GPY18_RS12990	COG0469	pyruvate kinase activity
GPY18_RS12995	COG3706	GGDEF domain
GPY18_RS13010	COG1279	arginine transmembrane transporter activity
GPY18_RS13020	COG0668	transmembrane transport
GPY18_RS13025	COG0191	fructose-bisphosphate aldolase activity
GPY18_RS13030	COG0126	phosphoglycerate kinase activity
GPY18_RS13035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY18_RS13040	COG4771	TonB-dependent receptor
GPY18_RS13045	COG0583	DNA-binding transcription factor activity
GPY18_RS13050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY18_RS13070	COG2356	endonuclease I
GPY18_RS13075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY18_RS13080	COG0189	ligase activity
GPY18_RS13085	COG1678	Uncharacterized ACR, COG1678
GPY18_RS13105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY18_RS13110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY18_RS13115	COG0762	integral membrane protein
GPY18_RS13120	COG1872	DUF167
GPY18_RS13135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY18_RS13140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY18_RS13145	COG2066	Belongs to the glutaminase family
GPY18_RS13150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY18_RS13155	COG1194	a g-specific adenine glycosylase
GPY18_RS13160	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY18_RS13165	COG0741	lytic transglycosylase activity
GPY18_RS13220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY18_RS13225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY18_RS13230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY18_RS13245	COG2967	ApaG domain
GPY18_RS13260	COG3610	response to peptide
GPY18_RS13265	COG2966	Psort location CytoplasmicMembrane, score
GPY18_RS13270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY18_RS13275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY18_RS13280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY18_RS13285	COG0142	geranyltranstransferase activity
GPY18_RS13290	COG0531	amino acid
GPY18_RS13295	COG0039	L-malate dehydrogenase activity
GPY18_RS13315	COG0589	response to stress
GPY18_RS13335	COG0312	modulator of DNA gyrase
GPY18_RS13340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY18_RS13345	COG3164	Protein of unknown function
GPY18_RS13350	COG1530	ribonuclease E activity
GPY18_RS13355	COG0424	maF-like protein
GPY18_RS13360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY18_RS13365	COG1792	Involved in formation and maintenance of cell shape
GPY18_RS13370	COG1077	Cell shape determining protein MreB Mrl
GPY18_RS13420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY18_RS13430	COG3409	Peptidoglycan-binding domain 1 protein
GPY18_RS13430	COG3267	Type II secretory pathway component ExeA
GPY18_RS13455	COG2199	diguanylate cyclase activity
GPY18_RS13455	COG2200	EAL domain
GPY18_RS13460	COG0629	single-stranded DNA binding
GPY18_RS13475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY18_RS13485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY18_RS13490	COG0527	aspartate kinase activity
GPY18_RS13495	COG1410	methionine synthase
GPY18_RS13495	COG0646	methionine synthase
GPY18_RS13565	COG0175	sulfate reduction
GPY18_RS13595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY18_RS13600	COG0735	belongs to the Fur family
GPY18_RS13610	COG0166	Belongs to the GPI family
GPY18_RS13615	COG0432	Pfam Uncharacterised protein family UPF0047
GPY18_RS13620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY18_RS13625	COG0305	Participates in initiation and elongation during chromosome replication
GPY18_RS13635	COG0359	binds to the 23S rRNA
GPY18_RS13645	COG2965	DNA replication, synthesis of RNA primer
GPY18_RS13650	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY18_RS13660	COG2906	2 iron, 2 sulfur cluster binding
GPY18_RS13670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY18_RS13675	COG0049	tRNA binding
GPY18_RS13685	COG2168	tRNA wobble position uridine thiolation
GPY18_RS13690	COG2923	Belongs to the DsrF TusC family
GPY18_RS13700	COG2964	Protein conserved in bacteria
GPY18_RS13705	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY18_RS13715	COG2900	Belongs to the SlyX family
GPY18_RS13720	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY18_RS13725	COG0330	HflC and HflK could
GPY18_RS13730	COG0330	HflC and HflK could
GPY18_RS13735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY18_RS13740	COG1923	regulation of RNA biosynthetic process
GPY18_RS13745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY18_RS13750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY18_RS13760	COG0802	atpase or kinase
GPY18_RS13765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY18_RS13820	COG1162	GTPase activity
GPY18_RS13825	COG0688	phosphatidylethanolamine metabolic process
GPY18_RS13830	COG0490	domain, Protein
GPY18_RS13830	COG0471	metal ion transport
GPY18_RS13845	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY18_RS13850	COG4942	peptidase
GPY18_RS13875	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY18_RS13880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY18_RS13885	COG0085	RNA polymerase activity
GPY18_RS13895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY18_RS13900	COG0081	regulation of translation
GPY18_RS13905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY18_RS13910	COG0250	Participates in transcription elongation, termination and antitermination
GPY18_RS13915	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY18_RS13945	COG1072	(Pantothenic acid kinase))
GPY18_RS13955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY18_RS13965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY18_RS14030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY18_RS14040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY18_RS14045	COG3118	belongs to the thioredoxin family
GPY18_RS14050	COG0513	Belongs to the DEAD box helicase family
GPY18_RS14055	COG0248	Ppx GppA phosphatase
GPY18_RS14060	COG0784	Response regulator, receiver
GPY18_RS14060	COG2198	Histidine kinase
GPY18_RS14060	COG2205	protein histidine kinase activity
GPY18_RS14060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY18_RS14065	COG2814	Major facilitator Superfamily
GPY18_RS14080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY18_RS14085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY18_RS14090	COG0511	ligase activity, forming carbon-carbon bonds
GPY18_RS14095	COG0439	Biotin carboxylase
GPY18_RS14100	COG2264	protein methyltransferase activity
GPY18_RS14105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY18_RS14110	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY18_RS14115	COG0840	transmembrane signaling receptor activity
GPY18_RS14120	COG0789	Transcriptional regulator
GPY18_RS14130	COG0138	bifunctional purine biosynthesis protein purh
GPY18_RS14135	COG0151	Belongs to the GarS family
GPY18_RS14145	COG0776	regulation of translation
GPY18_RS14150	COG1253	flavin adenine dinucleotide binding
GPY18_RS14155	COG0668	transmembrane transport
GPY18_RS14160	COG3068	Protein conserved in bacteria
GPY18_RS14165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY18_RS14170	COG1573	uracil-dna glycosylase
GPY18_RS14175	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY18_RS14180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY18_RS14205	COG1086	Polysaccharide biosynthesis protein
GPY18_RS14215	COG0438	transferase activity, transferring glycosyl groups
GPY18_RS14220	COG1388	LysM domain
GPY18_RS14220	COG4641	Protein conserved in bacteria
GPY18_RS14275	COG1596	polysaccharide export
GPY18_RS14295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY18_RS14300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY18_RS14310	COG1560	Kdo2-lipid A biosynthetic process
GPY18_RS14320	COG0859	PFAM glycosyl transferase family 9
GPY18_RS14325	COG0859	PFAM glycosyl transferase family 9
GPY18_RS14330	COG1519	Transferase
GPY18_RS14335	COG0438	transferase activity, transferring glycosyl groups
GPY18_RS14345	COG0859	PFAM glycosyl transferase family 9
GPY18_RS14350	COG0463	Glycosyl transferase, family 2
GPY18_RS14355	COG0438	transferase activity, transferring glycosyl groups
GPY18_RS14360	COG0438	transferase activity, transferring glycosyl groups
GPY18_RS14365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY18_RS14380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY18_RS14390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY18_RS14410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY18_RS14415	COG1309	transcriptional regulator
GPY18_RS14420	COG1560	Kdo2-lipid A biosynthetic process
GPY18_RS14425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY18_RS14430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY18_RS14435	COG1561	YicC-like family, N-terminal region
GPY18_RS14455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY18_RS14460	COG1120	ATPase activity
GPY18_RS14465	COG1132	(ABC) transporter
GPY18_RS14480	COG0514	ATP-dependent DNA helicase (RecQ)
GPY18_RS14485	COG2962	Rard protein
GPY18_RS14495	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS14500	COG0405	Gamma-glutamyltransferase
GPY18_RS14505	COG0210	DNA helicase
GPY18_RS14540	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY18_RS14545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY18_RS14560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY18_RS14565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY18_RS14575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY18_RS14585	COG0747	negative chemotaxis
GPY18_RS14590	COG4172	Belongs to the ABC transporter superfamily
GPY18_RS14625	COG0210	DNA helicase
GPY18_RS14635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY18_RS14640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY18_RS14645	COG2960	long-chain fatty acid transporting porin activity
GPY18_RS14655	COG0583	DNA-binding transcription factor activity
GPY18_RS14700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY18_RS14710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY18_RS14715	COG0408	coproporphyrinogen oxidase activity
GPY18_RS14730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY18_RS14735	COG0551	DNA topoisomerase type I activity
GPY18_RS14740	COG2922	Belongs to the Smg family
GPY18_RS14745	COG0758	DNA mediated transformation
GPY18_RS14750	COG1652	LysM domain
GPY18_RS14755	COG0242	peptide deformylase activity
GPY18_RS14765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY18_RS14765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY18_RS14770	COG0569	domain protein
GPY18_RS14775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY18_RS14785	COG1272	protein, Hemolysin III
GPY18_RS14790	COG4326	sporulation control protein
GPY18_RS14800	COG3084	Protein conserved in bacteria
GPY18_RS14810	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY18_RS14815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY18_RS14820	COG0204	Acyl-transferase
GPY18_RS14825	COG0606	chelatase, subunit chli
GPY18_RS14835	COG3978	acetolactate synthase activity
GPY18_RS14840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY18_RS14855	COG0604	alcohol dehydrogenase
GPY18_RS14880	COG2119	membrane
GPY18_RS14885	COG0752	glycyl-tRNA synthetase alpha subunit
GPY18_RS14890	COG0751	glycine-tRNA ligase activity
GPY18_RS14895	COG3977	Valine--pyruvate aminotransferase
GPY18_RS14900	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY18_RS14905	COG0187	DNA topoisomerase II activity
GPY18_RS14910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY18_RS14915	COG0592	DNA-directed DNA polymerase activity
GPY18_RS14920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY18_RS14935	COG1126	abc transporter atp-binding protein
GPY18_RS14940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY18_RS14950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY18_RS14955	COG0706	membrane insertase activity
GPY18_RS14960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY18_RS14965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY18_RS14970	COG0445	tRNA wobble uridine modification
GPY18_RS14975	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY18_RS14980	COG1192	Involved in chromosome partitioning
GPY18_RS14985	COG1475	DNA binding
GPY18_RS14990	COG3312	ion transport
GPY18_RS14995	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY18_RS15005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY18_RS15010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY18_RS15020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY18_RS15025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY18_RS15030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY18_RS15040	COG0765	amino acid transport
GPY18_RS15045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY18_RS15050	COG2814	Major facilitator Superfamily
GPY18_RS15055	COG0583	DNA-binding transcription factor activity
GPY18_RS15060	COG0183	Belongs to the thiolase family
GPY18_RS15070	COG1739	Uncharacterized protein family UPF0029
GPY18_RS15075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY18_RS15130	COG2132	Multicopper oxidase
GPY18_RS15135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY18_RS15140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY18_RS15145	COG0352	thiamine-phosphate diphosphorylase activity
GPY18_RS15150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY18_RS15155	COG2104	thiamine diphosphate biosynthetic process
GPY18_RS15155	COG2022	thiamine diphosphate biosynthetic process
GPY18_RS15170	COG4175	Glycine betaine
GPY18_RS15170	COG0517	IMP dehydrogenase activity
GPY18_RS15200	COG0006	proline dipeptidase activity
GPY18_RS15200	COG0006	proline dipeptidase activity
GPY18_RS15220	COG1522	sequence-specific DNA binding
GPY18_RS15225	COG5002	protein histidine kinase activity
GPY18_RS15225	COG5001	Diguanylate cyclase
GPY18_RS15230	COG0742	ribosomal rna small subunit methyltransferase
GPY18_RS15245	COG0589	response to stress
GPY18_RS15250	COG1528	Iron-storage protein
GPY18_RS15260	COG2081	HI0933 family
GPY18_RS15265	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY18_RS15270	COG1129	ABC transporter
GPY18_RS15275	COG1879	ABC-type sugar transport system periplasmic component
GPY18_RS15280	COG1069	ribulokinase activity
GPY18_RS15285	COG0235	Class ii aldolase
GPY18_RS15290	COG2160	L-arabinose isomerase activity
GPY18_RS15315	COG1322	Protein conserved in bacteria
GPY18_RS15320	COG2226	methyltransferase
GPY18_RS15325	COG3165	ubiquinone biosynthetic process from chorismate
GPY18_RS15330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY18_RS15340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY18_RS15345	COG0805	protein transport
GPY18_RS15350	COG0084	hydrolase, TatD family'
GPY18_RS15365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY18_RS15365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY18_RS15370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY18_RS15395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY18_RS15400	COG3071	HemY protein
GPY18_RS15405	COG2959	enzyme of heme biosynthesis
GPY18_RS15420	COG3072	Adenylate cyclase
GPY18_RS15435	COG0019	diaminopimelate decarboxylase activity
GPY18_RS15440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY18_RS15450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY18_RS15455	COG1011	Hydrolase
GPY18_RS15460	COG2199	diguanylate cyclase activity
GPY18_RS15460	COG3287	FIST C domain
GPY18_RS15460	COG2200	EAL domain
GPY18_RS15480	COG0561	phosphatase activity
GPY18_RS15485	COG2267	carboxylic ester hydrolase activity
GPY18_RS15490	COG1280	lysine exporter protein (LysE YggA)
GPY18_RS15495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY18_RS15500	COG0640	Transcriptional regulator
GPY18_RS15505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY18_RS15520	COG0783	Belongs to the Dps family
GPY18_RS15550	COG2095	MarC family integral membrane protein
GPY18_RS15560	COG0742	ribosomal rna small subunit methyltransferase
GPY18_RS15565	COG0552	protein localization to endoplasmic reticulum
GPY18_RS15570	COG2884	Cell division ATP-binding protein ftsE
GPY18_RS15575	COG2177	Part of the ABC transporter FtsEX involved in
GPY18_RS15580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY18_RS15590	COG0705	Rhomboid family
GPY18_RS15595	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY18_RS15600	COG3161	chorismate lyase activity
GPY18_RS15605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY18_RS15610	COG2937	Belongs to the GPAT DAPAT family
GPY18_RS15615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY18_RS15620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY18_RS15630	COG0534	Mate efflux family protein
GPY18_RS15650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY18_RS15665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY18_RS15725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY18_RS15730	COG3300	MHYT domain
GPY18_RS15730	COG5001	Diguanylate cyclase
GPY18_RS15735	COG2204	response regulator
GPY18_RS15740	COG3852	Histidine kinase
GPY18_RS15750	COG0174	glutamine synthetase
GPY18_RS15775	COG1490	D-aminoacyl-tRNA deacylase activity
GPY18_RS15780	COG0456	acetyltransferase
GPY18_RS15785	COG2982	Protein involved in outer membrane biogenesis
GPY18_RS15790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY18_RS15795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY18_RS15800	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY18_RS15805	COG3031	protein transport across the cell outer membrane
GPY18_RS15815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY18_RS15820	COG1459	type II secretion system
GPY18_RS15825	COG2165	general secretion pathway protein
GPY18_RS15830	COG2165	general secretion pathway protein
GPY18_RS15835	COG2165	general secretion pathway protein
GPY18_RS15840	COG4795	General secretion pathway protein
GPY18_RS15845	COG3156	type II secretion system protein K
GPY18_RS15850	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY18_RS15855	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY18_RS15865	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY18_RS15870	COG0494	nUDIX hydrolase
GPY18_RS15875	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY18_RS15875	COG0316	Belongs to the HesB IscA family
GPY18_RS15880	COG1040	competence protein
GPY18_RS15895	COG2183	response to ionizing radiation
GPY18_RS15905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY18_RS15910	COG1609	Transcriptional regulator
GPY18_RS15915	COG0129	dihydroxy-acid dehydratase activity
GPY18_RS15920	COG3265	gluconokinase activity
GPY18_RS15925	COG2610	gluconate transmembrane transporter activity
GPY18_RS15930	COG0800	Aldolase
GPY18_RS15935	COG0745	RESPONSE REGULATOR receiver
GPY18_RS15940	COG2205	protein histidine kinase activity
GPY18_RS15945	COG2233	PERMEase
GPY18_RS15950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY18_RS15955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY18_RS15960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY18_RS15970	COG0194	GDP metabolic process
GPY18_RS15975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY18_RS15980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY18_RS15990	COG3263	regulation of cellular component size
GPY18_RS16000	COG4232	protein-disulfide reductase activity
GPY18_RS16010	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY18_RS16015	COG0540	Belongs to the ATCase OTCase family
GPY18_RS16020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY18_RS16035	COG1288	antiporter activity
GPY18_RS16040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY18_RS16045	COG1027	Aspartate ammonia-lyase
GPY18_RS16050	COG3706	GGDEF domain
GPY18_RS16055	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY18_RS16060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY18_RS16065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GPY18_RS16070	COG2205	protein histidine kinase activity
GPY18_RS16075	COG0745	RESPONSE REGULATOR receiver
GPY18_RS16085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY18_RS16090	COG0205	6-phosphofructokinase activity
GPY18_RS16095	COG1494	fructose-1,6-bisphosphatase
GPY18_RS16105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY18_RS16110	COG0527	aspartate kinase activity
GPY18_RS16110	COG0460	homoserine dehydrogenase
GPY18_RS16115	COG0626	cystathionine gamma-synthase activity
GPY18_RS16125	COG0281	malic enzyme
GPY18_RS16130	COG0254	rRNA binding
GPY18_RS16135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY18_RS16140	COG1609	Transcriptional regulator
GPY18_RS16150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY18_RS16155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY18_RS16160	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY18_RS16165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY18_RS16175	COG0149	triose-phosphate isomerase activity
GPY18_RS16200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY18_RS16205	COG0459	protein refolding
GPY18_RS16210	COG1119	ATPase activity
GPY18_RS16220	COG1285	pathogenesis
GPY18_RS16225	COG1509	lysine 2,3-aminomutase activity
GPY18_RS16230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY18_RS16235	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY18_RS16240	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY18_RS16245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY18_RS16250	COG1053	succinate dehydrogenase
GPY18_RS16255	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY18_RS16260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY18_RS16265	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY18_RS16270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY18_RS16275	COG1045	serine acetyltransferase
GPY18_RS16280	COG1695	Transcriptional regulator
GPY18_RS16285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY18_RS16290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY18_RS16295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY18_RS16300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY18_RS16310	COG0165	Argininosuccinate lyase
GPY18_RS16310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY18_RS16320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY18_RS16320	COG0678	peroxiredoxin activity
GPY18_RS16330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY18_RS16365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY18_RS16375	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY18_RS16380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY18_RS16390	COG0180	Tryptophanyl-tRNA synthetase
GPY18_RS16400	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY18_RS16410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY18_RS16420	COG1012	belongs to the aldehyde dehydrogenase family
GPY18_RS16430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY18_RS16435	COG3954	Phosphoribulokinase
GPY18_RS16445	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY18_RS16455	COG0488	(ABC) transporter
GPY18_RS16460	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY18_RS16470	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GPY18_RS16475	COG1047	Peptidyl-prolyl cis-trans
GPY18_RS16485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY18_RS16490	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY18_RS16495	COG3083	sulfuric ester hydrolase activity
GPY18_RS16500	COG0557	exoribonuclease II activity
GPY18_RS16505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY18_RS16510	COG0051	transcription antitermination factor activity, RNA binding
GPY18_RS16515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY18_RS16520	COG0088	Forms part of the polypeptide exit tunnel
GPY18_RS16525	COG0089	rRNA binding
GPY18_RS16535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY18_RS16540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY18_RS16555	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY18_RS16565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY18_RS16570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY18_RS16575	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY18_RS16580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY18_RS16585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY18_RS16590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY18_RS16595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY18_RS16605	COG1841	ribosomal large subunit assembly
GPY18_RS16615	COG0201	protein transport
GPY18_RS16630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY18_RS16635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY18_RS16640	COG0202	RNA polymerase activity
GPY18_RS16645	COG0203	ribosomal protein L17
GPY18_RS16655	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY18_RS16660	COG3061	Opacity-associated protein A
GPY18_RS16665	COG0697	spore germination
GPY18_RS16670	COG2153	protein acetylation
GPY18_RS16675	COG0513	Belongs to the DEAD box helicase family
GPY18_RS16685	COG0737	Belongs to the 5'-nucleotidase family
GPY18_RS16690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY18_RS16690	COG1648	precorrin-2 dehydrogenase activity
GPY18_RS16695	COG0175	sulfate reduction
GPY18_RS16700	COG2895	sulfate adenylyltransferase (ATP) activity
GPY18_RS16705	COG0490	domain, Protein
GPY18_RS16705	COG0471	metal ion transport
GPY18_RS16710	COG0529	Catalyzes the synthesis of activated sulfate
GPY18_RS16735	COG0577	efflux transmembrane transporter activity
GPY18_RS16735	COG1136	(ABC) transporter
GPY18_RS16750	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY18_RS16755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY18_RS16760	COG0729	surface antigen
GPY18_RS16770	COG2105	PFAM AIG2 family protein
GPY18_RS16775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY18_RS16780	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY18_RS16785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY18_RS16790	COG0163	prenyltransferase activity
GPY18_RS16795	COG4143	(ABC) transporter
GPY18_RS16800	COG1178	ABC-type Fe3 transport system permease component
GPY18_RS16805	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY18_RS16810	COG3028	Belongs to the UPF0307 family
GPY18_RS16815	COG0312	modulator of DNA gyrase
GPY18_RS16820	COG2239	Acts as a magnesium transporter
GPY18_RS16825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS16835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY18_RS16840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY18_RS16850	COG1137	ATPase activity
GPY18_RS16855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY18_RS16865	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GPY18_RS16870	COG0517	IMP dehydrogenase activity
GPY18_RS16870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY18_RS16880	COG1127	ABC transporter
GPY18_RS16885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY18_RS16890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY18_RS16895	COG2854	intermembrane phospholipid transfer
GPY18_RS16900	COG3113	response to antibiotic
GPY18_RS16905	COG5007	Belongs to the BolA IbaG family
GPY18_RS16910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY18_RS16915	COG0204	Acyl-transferase
GPY18_RS16920	COG0251	oxidation-reduction process
GPY18_RS16925	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY18_RS16930	COG0540	Belongs to the ATCase OTCase family
GPY18_RS16935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY18_RS16940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY18_RS16950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY18_RS16960	COG0564	pseudouridine synthase activity
GPY18_RS16965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY18_RS16970	COG0525	valine-tRNA ligase activity
GPY18_RS16985	COG0795	lipopolysaccharide-transporting ATPase activity
GPY18_RS16990	COG0795	lipopolysaccharide-transporting ATPase activity
GPY18_RS17000	COG3706	GGDEF domain
GPY18_RS17020	COG2199	diguanylate cyclase activity
GPY18_RS17020	COG2200	EAL domain
GPY18_RS17020	COG2203	Gaf domain
GPY18_RS17030	COG3437	response regulator, receiver
GPY18_RS17080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY18_RS17085	COG0473	3-isopropylmalate dehydrogenase activity
GPY18_RS17090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY18_RS17110	COG0583	DNA-binding transcription factor activity
GPY18_RS17115	COG1022	Amp-dependent synthetase and ligase
GPY18_RS17120	COG0028	Belongs to the TPP enzyme family
GPY18_RS17125	COG0440	acetolactate synthase activity
GPY18_RS17130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY18_RS17140	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY18_RS17150	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY18_RS17160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY18_RS17165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY18_RS17180	COG0354	folic acid binding
GPY18_RS17185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY18_RS17195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY18_RS17200	COG1595	DNA-templated transcription, initiation
GPY18_RS17215	COG3086	response to oxidative stress
GPY18_RS17220	COG0481	GTPase activity
GPY18_RS17225	COG0681	Belongs to the peptidase S26 family
GPY18_RS17230	COG0571	ribonuclease III activity
GPY18_RS17235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY18_RS17240	COG1381	Involved in DNA repair and RecF pathway recombination
GPY18_RS17245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY18_RS17250	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY18_RS17260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY18_RS17265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY18_RS17270	COG3956	TIGRFAM MazG family protein
GPY18_RS17275	COG0504	CTP synthase activity
GPY18_RS17280	COG0148	phosphopyruvate hydratase activity
GPY18_RS17285	COG0617	tRNA 3'-terminal CCA addition
GPY18_RS17290	COG3409	Peptidoglycan-binding domain 1 protein
GPY18_RS17290	COG3267	Type II secretory pathway component ExeA
GPY18_RS17300	COG4991	sh3 domain protein
GPY18_RS17305	COG0306	phosphate transporter
GPY18_RS17310	COG1392	Phosphate transport regulator
GPY18_RS17315	COG3025	triphosphatase activity
GPY18_RS17320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY18_RS17330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY18_RS17335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY18_RS17335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY18_RS17340	COG1538	Outer membrane efflux protein
GPY18_RS17345	COG0494	nUDIX hydrolase
GPY18_RS17350	COG3151	Protein conserved in bacteria
GPY18_RS17360	COG3150	esterase
GPY18_RS17365	COG0187	DNA topoisomerase II activity
GPY18_RS17370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY18_RS17375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY18_RS17380	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY18_RS17395	COG1459	type II secretion system
GPY18_RS17400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY18_RS17420	COG0716	FMN binding
GPY18_RS17425	COG4974	Belongs to the 'phage' integrase family
GPY18_RS17430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY18_RS17435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY18_RS17440	COG2186	Transcriptional regulator
GPY18_RS17445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY18_RS17450	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY18_RS17455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY18_RS17470	COG0288	reversible hydration of carbon dioxide
GPY18_RS17475	COG1131	(ABC) transporter
GPY18_RS17480	COG0842	Transport permease protein
GPY18_RS17485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY18_RS17490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY18_RS17495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY18_RS17505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY18_RS17510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY18_RS17515	COG1489	DNA binding
GPY18_RS17520	COG1643	Atp-dependent helicase
GPY18_RS17525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY18_RS17530	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY18_RS17535	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY18_RS17540	COG3112	Uncharacterised protein family (UPF0231)
GPY18_RS17545	COG0347	Belongs to the P(II) protein family
GPY18_RS17550	COG0004	ammonium transporteR
GPY18_RS17555	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY18_RS17565	COG3842	ATPase activity
GPY18_RS17570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY18_RS17585	COG2971	BadF BadG BcrA BcrD
GPY18_RS17595	COG4608	Belongs to the ABC transporter superfamily
GPY18_RS17605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY18_RS17615	COG0747	negative chemotaxis
GPY18_RS17630	COG0628	permease
GPY18_RS17640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY18_RS17645	COG0316	Belongs to the HesB IscA family
GPY18_RS17660	COG0739	heme binding
GPY18_RS17665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY18_RS17675	COG2239	Acts as a magnesium transporter
GPY18_RS17680	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY18_RS17685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY18_RS17690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY18_RS17695	COG1534	Rna-binding protein
GPY18_RS17705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY18_RS17710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY18_RS17715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY18_RS17720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY18_RS17735	COG0779	Required for maturation of 30S ribosomal subunits
GPY18_RS17740	COG0195	Participates in both transcription termination and antitermination
GPY18_RS17750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY18_RS17755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY18_RS17780	COG0534	Mate efflux family protein
GPY18_RS17805	COG3153	acetyltransferase
GPY18_RS17825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY18_RS17830	COG0513	Belongs to the DEAD box helicase family
GPY18_RS17850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY18_RS17855	COG2204	response regulator
GPY18_RS17865	COG0667	Aldo Keto reductase
GPY18_RS17875	COG3066	DNA modification
GPY18_RS17880	COG0494	nUDIX hydrolase
GPY18_RS17890	COG0730	response to heat
GPY18_RS17900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY18_RS17905	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY18_RS17910	COG0583	DNA-binding transcription factor activity
GPY18_RS17915	COG0640	Transcriptional regulator
GPY18_RS17925	COG0728	peptidoglycan biosynthetic process
GPY18_RS17930	COG0196	riboflavin kinase activity
GPY18_RS17935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY18_RS17940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY18_RS17945	COG1047	Peptidyl-prolyl cis-trans
GPY18_RS17950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY18_RS17955	COG1966	Carbon starvation protein
GPY18_RS17970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY18_RS17975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY18_RS17985	COG3279	Response regulator of the LytR AlgR family
GPY18_RS17990	COG3275	phosphorelay sensor kinase activity
GPY18_RS17995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY18_RS18000	COG1605	Chorismate mutase
GPY18_RS18000	COG0287	Prephenate dehydrogenase
GPY18_RS18010	COG0488	(ABC) transporter
GPY18_RS18025	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY18_RS18030	COG5001	Diguanylate cyclase
GPY18_RS18035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY18_RS18040	COG0077	Prephenate dehydratase
GPY18_RS18040	COG1605	Chorismate mutase
GPY18_RS18045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY18_RS18050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY18_RS18055	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY18_RS18060	COG0564	pseudouridine synthase activity
GPY18_RS18070	COG0542	response to heat
GPY18_RS18080	COG0590	tRNA wobble adenosine to inosine editing
GPY18_RS18085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY18_RS18090	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GPY18_RS18170	COG0271	Belongs to the BolA IbaG family
GPY18_RS18175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY18_RS18180	COG1805	sodium ion transport
GPY18_RS18190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY18_RS18195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY18_RS18205	COG1477	protein flavinylation
GPY18_RS18220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY18_RS18230	COG2203	Gaf domain
GPY18_RS18230	COG3706	GGDEF domain
GPY18_RS18230	COG4251	negative regulation of phosphorylation
GPY18_RS18230	COG5001	Diguanylate cyclase
GPY18_RS18235	COG0733	neurotransmitter:sodium symporter activity
GPY18_RS18245	COG0189	ligase activity
GPY18_RS18250	COG4067	protein conserved in archaea
GPY18_RS18250	COG0189	ligase activity
GPY18_RS18255	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY18_RS18260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS18265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY18_RS18275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY18_RS18285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY18_RS18290	COG2252	PERMEase
GPY18_RS18295	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY18_RS18310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY18_RS18315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY18_RS18320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY18_RS18325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY18_RS18325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY18_RS18345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY18_RS18350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY18_RS18355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY18_RS18365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY18_RS18370	COG0024	Methionine aminopeptidase
GPY18_RS18395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY18_RS18400	COG0575	Belongs to the CDS family
GPY18_RS18405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY18_RS18410	COG0750	zinc metalloprotease
GPY18_RS18420	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY18_RS18425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY18_RS18430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY18_RS18450	COG0587	DNA-directed DNA polymerase activity
GPY18_RS18455	COG0825	malonyl-CoA metabolic process
GPY18_RS18460	COG0037	tRNA processing
GPY18_RS18470	COG0347	Belongs to the P(II) protein family
GPY18_RS18485	COG0741	lytic transglycosylase activity
GPY18_RS18485	COG1388	LysM domain
GPY18_RS18490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY18_RS18495	COG2226	methyltransferase
GPY18_RS18500	COG0328	RNA-DNA hybrid ribonuclease activity
GPY18_RS18505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY18_RS18515	COG1960	acyl-CoA dehydrogenase activity
GPY18_RS18520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY18_RS18525	COG0121	glutamine amidotransferase
GPY18_RS18530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY18_RS18535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY18_RS18540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY18_RS18545	COG1187	pseudouridine synthase activity
GPY18_RS18550	COG2840	Smr protein MutS2
GPY18_RS18580	COG2608	mercury ion transmembrane transporter activity
GPY18_RS18580	COG2217	Heavy metal translocating P-type atpase
GPY18_RS18585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY18_RS18605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY18_RS18610	COG2194	sulfuric ester hydrolase activity
GPY18_RS18645	COG2747	anti-sigma28 factor FlgM
GPY18_RS18655	COG0835	chemotaxis
GPY18_RS18655	COG0784	Response regulator, receiver
GPY18_RS18660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY18_RS18665	COG1815	bacterial-type flagellum-dependent cell motility
GPY18_RS18670	COG1558	bacterial-type flagellum-dependent cell motility
GPY18_RS18675	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY18_RS18680	COG1749	Flagellar hook protein flgE
GPY18_RS18685	COG4787	bacterial-type flagellum-dependent cell motility
GPY18_RS18690	COG4786	Flagellar basal body rod
GPY18_RS18695	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY18_RS18700	COG1706	bacterial-type flagellum-dependent cell motility
GPY18_RS18705	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY18_RS18705	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY18_RS18720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY18_RS18820	COG0193	aminoacyl-tRNA hydrolase activity
GPY18_RS18825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY18_RS18835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY18_RS18840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY18_RS18845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY18_RS18850	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY18_RS18855	COG3094	Invasion gene expression up-regulator, SirB
GPY18_RS18860	COG2912	Transglutaminase-like superfamily
GPY18_RS18870	COG0737	Belongs to the 5'-nucleotidase family
GPY18_RS18880	COG2233	PERMEase
GPY18_RS18900	COG1393	Belongs to the ArsC family
GPY18_RS18905	COG4783	chaperone-mediated protein folding
GPY18_RS18925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY18_RS18930	COG2716	regulation of RNA biosynthetic process
GPY18_RS18935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY18_RS18940	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY18_RS18950	COG1876	peptidase activity
GPY18_RS18955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY18_RS18960	COG1393	Belongs to the ArsC family
GPY18_RS18970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY18_RS18980	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY18_RS19000	COG2837	iron assimilation
GPY18_RS19010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY18_RS19015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY18_RS19020	COG1334	flagellar protein FlaG
GPY18_RS19025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY18_RS19035	COG1516	flagellar protein fliS
GPY18_RS19040	COG2204	response regulator
GPY18_RS19045	COG4191	Histidine kinase
GPY18_RS19050	COG2204	response regulator
GPY18_RS19055	COG1677	Flagellar hook-basal body complex protein FliE
GPY18_RS19065	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY18_RS19115	COG1987	bacterial-type flagellum assembly
GPY18_RS19135	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY18_RS19140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY18_RS19145	COG0583	DNA-binding transcription factor activity
GPY18_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS19155	COG2860	membrane
GPY18_RS19160	COG3101	peptidyl-lysine hydroxylation
GPY18_RS19180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY18_RS19185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY18_RS19190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY18_RS19195	COG0735	belongs to the Fur family
GPY18_RS19205	COG0583	DNA-binding transcription factor activity
GPY18_RS19210	COG1380	Effector of murein hydrolase LrgA
GPY18_RS19215	COG1346	cytolysis
GPY18_RS19230	COG0596	Alpha beta hydrolase
GPY18_RS19235	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY18_RS19240	COG0033	Phosphoglucomutase
GPY18_RS19250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY18_RS19260	COG2009	succinate dehydrogenase
GPY18_RS19265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY18_RS19280	COG0567	Dehydrogenase, E1 component
GPY18_RS19285	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY18_RS19300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY18_RS19305	COG1121	(ABC) transporter
GPY18_RS19310	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY18_RS19320	COG1918	ferrous iron import across plasma membrane
GPY18_RS19340	COG0018	arginyl-trna synthetase
GPY18_RS19345	COG3102	Protein conserved in bacteria
GPY18_RS19355	COG2062	phosphohistidine phosphatase, SixA
GPY18_RS19370	COG0455	bacterial-type flagellum organization
GPY18_RS19385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY18_RS19390	COG0643	Histidine kinase
GPY18_RS19390	COG2198	Histidine kinase
GPY18_RS19395	COG2201	protein-glutamate methylesterase activity
GPY18_RS19400	COG1192	Involved in chromosome partitioning
GPY18_RS19410	COG0835	chemotaxis
GPY18_RS19420	COG4133	protoheme IX ABC transporter activity
GPY18_RS19425	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY18_RS19430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY18_RS19435	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY18_RS19440	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY18_RS19445	COG1138	Cytochrome C-type biogenesis protein
GPY18_RS19450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY18_RS19465	COG2853	Lipoprotein
GPY18_RS19485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY18_RS19490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY18_RS19495	COG3384	dioxygenase
GPY18_RS19520	COG0667	Aldo Keto reductase
GPY18_RS19535	COG0583	DNA-binding transcription factor activity
GPY18_RS19540	COG2159	amidohydrolase
GPY18_RS19545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY18_RS19585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY18_RS19600	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY18_RS19625	COG3083	sulfuric ester hydrolase activity
GPY18_RS19635	COG3081	Nucleoid-associated protein
GPY18_RS19645	COG1757	Na H antiporter
GPY18_RS19650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY18_RS19655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY18_RS19660	COG2095	MarC family integral membrane protein
GPY18_RS19665	COG1454	alcohol dehydrogenase
GPY18_RS19665	COG1012	belongs to the aldehyde dehydrogenase family
GPY18_RS19675	COG0659	secondary active sulfate transmembrane transporter activity
GPY18_RS19685	COG1530	ribonuclease E activity
GPY18_RS19690	COG0564	pseudouridine synthase activity
GPY18_RS19695	COG0424	maF-like protein
GPY18_RS19700	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY18_RS19710	COG0416	fatty acid biosynthetic process
GPY18_RS19715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY18_RS19735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY18_RS19740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY18_RS19745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY18_RS19750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY18_RS19755	COG0470	DNA polymerase III
GPY18_RS19760	COG0084	hydrolase, TatD family'
GPY18_RS19765	COG2190	(PTS) system
GPY18_RS19765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY18_RS19765	COG1263	PTS System
GPY18_RS19775	COG1263	PTS System
GPY18_RS19775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY18_RS19790	COG0733	neurotransmitter:sodium symporter activity
GPY18_RS19805	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY18_RS19810	COG0469	pyruvate kinase activity
GPY18_RS19815	COG1940	carbohydrate kinase activity
GPY18_RS19820	COG0835	chemotaxis
GPY18_RS19820	COG0784	Response regulator, receiver
GPY18_RS19825	COG0587	DNA-directed DNA polymerase activity
GPY18_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS19845	COG0616	signal peptide processing
GPY18_RS19885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY18_RS19890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY18_RS19895	COG0436	Aminotransferase
GPY18_RS19900	COG1169	isochorismate synthase
GPY18_RS19905	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY18_RS19910	COG0596	Alpha beta hydrolase
GPY18_RS19915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY18_RS19920	COG1441	menaquinone biosynthetic process
GPY18_RS19935	COG2855	membrane
GPY18_RS19940	COG0477	Major facilitator Superfamily
GPY18_RS19960	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GPY18_RS19965	COG1388	LysM domain
GPY18_RS19965	COG0741	lytic transglycosylase activity
GPY18_RS19985	COG1815	bacterial-type flagellum-dependent cell motility
GPY18_RS19990	COG1558	bacterial-type flagellum-dependent cell motility
GPY18_RS19995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY18_RS20000	COG1749	Flagellar hook protein flgE
GPY18_RS20010	COG4786	Flagellar basal body rod
GPY18_RS20015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY18_RS20020	COG1706	bacterial-type flagellum-dependent cell motility
GPY18_RS20030	COG4786	Flagellar basal body rod
GPY18_RS20030	COG1256	bacterial-type flagellum assembly
GPY18_RS20055	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GPY18_RS20090	COG0702	epimerase
GPY18_RS20095	COG3015	lipoprotein NlpE involved in copper resistance
GPY18_RS20105	COG1360	Flagellar Motor Protein
GPY18_RS20110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY18_RS20115	COG1191	sigma factor activity
GPY18_RS20120	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY18_RS20140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY18_RS20145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY18_RS20160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY18_RS20170	COG1987	bacterial-type flagellum assembly
GPY18_RS20190	COG2885	chlorophyll binding
GPY18_RS20195	COG2204	response regulator
GPY18_RS20210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY18_RS20235	COG1522	sequence-specific DNA binding
GPY18_RS20245	COG1946	Acyl-CoA thioesterase
GPY18_RS20250	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY18_RS20265	COG2199	diguanylate cyclase activity
GPY18_RS20265	COG2203	Gaf domain
GPY18_RS20280	COG1309	transcriptional regulator
GPY18_RS20300	COG4221	oxidoreductase activity
GPY18_RS20305	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS20315	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS20320	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS20325	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS20330	COG1073	alpha beta
GPY18_RS20360	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPY18_RS20370	COG0431	NADPH-dependent FMN reductase
GPY18_RS20375	COG0697	spore germination
GPY18_RS20385	COG1278	Cold shock
GPY18_RS20405	COG0431	NADPH-dependent FMN reductase
GPY18_RS20410	COG2207	Transcriptional regulator
GPY18_RS20415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS20420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY18_RS20420	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY18_RS20425	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY18_RS20430	COG1881	PFAM PEBP family protein
GPY18_RS20435	COG2207	Transcriptional regulator
GPY18_RS20465	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY18_RS20470	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY18_RS20485	COG0642	Histidine kinase
GPY18_RS20490	COG0745	RESPONSE REGULATOR receiver
GPY18_RS20495	COG0671	phosphoesterase, PA-phosphatase related
GPY18_RS20505	COG0513	Belongs to the DEAD box helicase family
GPY18_RS20510	COG1368	sulfuric ester hydrolase activity
GPY18_RS20515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY18_RS20520	COG2194	sulfuric ester hydrolase activity
GPY18_RS20565	COG2863	cytochrome
GPY18_RS20570	COG3258	Cytochrome c
GPY18_RS20585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY18_RS20590	COG1271	oxidase subunit
GPY18_RS20595	COG1294	oxidase, subunit
GPY18_RS20635	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY18_RS20640	COG2814	Major facilitator Superfamily
GPY18_RS20650	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY18_RS20655	COG1169	isochorismate synthase
GPY18_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS20665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY18_RS20670	COG3433	isochorismatase activity
GPY18_RS20670	COG2226	methyltransferase
GPY18_RS20670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY18_RS20685	COG4592	Periplasmic binding protein
GPY18_RS20690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY18_RS20695	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY18_RS20700	COG1629	transport
GPY18_RS20700	COG4774	siderophore transport
GPY18_RS20710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY18_RS20715	COG1120	ATPase activity
GPY18_RS20725	COG1609	Transcriptional regulator
GPY18_RS20730	COG2723	6-phospho-beta-galactosidase activity
GPY18_RS20735	COG1741	Belongs to the pirin family
GPY18_RS20740	COG0352	thiamine-phosphate diphosphorylase activity
GPY18_RS20750	COG0351	phosphomethylpyrimidine kinase
GPY18_RS20755	COG4172	Belongs to the ABC transporter superfamily
GPY18_RS20760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY18_RS20765	COG0601	transmembrane transport
GPY18_RS20770	COG0747	negative chemotaxis
GPY18_RS20780	COG1538	Outer membrane efflux protein
GPY18_RS20785	COG1566	PFAM secretion protein HlyD family protein
GPY18_RS20790	COG2814	Major facilitator Superfamily
GPY18_RS20795	COG2207	Transcriptional regulator
GPY18_RS20795	COG3708	Transcriptional regulator
GPY18_RS20805	COG0745	RESPONSE REGULATOR receiver
GPY18_RS20815	COG1263	PTS System
GPY18_RS20815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY18_RS20825	COG1621	beta-fructofuranosidase activity
GPY18_RS20830	COG2200	EAL domain
GPY18_RS20830	COG2202	Pas domain
GPY18_RS20830	COG2199	diguanylate cyclase activity
GPY18_RS20840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY18_RS20855	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS20890	COG2986	histidine ammonia-lyase
GPY18_RS20895	COG1216	Glycosyl transferase, family 2
GPY18_RS20905	COG0318	PFAM AMP-dependent synthetase and ligase
GPY18_RS20915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY18_RS20920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY18_RS20925	COG0204	Acyl-transferase
GPY18_RS20925	COG0318	PFAM AMP-dependent synthetase and ligase
GPY18_RS20955	COG0601	transmembrane transport
GPY18_RS20960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY18_RS20965	COG0444	Belongs to the ABC transporter superfamily
GPY18_RS20980	COG0435	Glutathione S-transferase
GPY18_RS20985	COG3174	membrane
GPY18_RS20990	COG0280	phosphate acetyltransferase
GPY18_RS20990	COG0857	belongs to the CobB CobQ family
GPY18_RS20995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY18_RS21000	COG3092	negative regulation of chromosome organization
GPY18_RS21010	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY18_RS21020	COG3706	GGDEF domain
GPY18_RS21035	COG0653	protein targeting
GPY18_RS21040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY18_RS21045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY18_RS21050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY18_RS21060	COG0243	molybdopterin cofactor binding
GPY18_RS21065	COG1648	precorrin-2 dehydrogenase activity
GPY18_RS21065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY18_RS21080	COG1116	anion transmembrane transporter activity
GPY18_RS21080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY18_RS21085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY18_RS21090	COG1116	anion transmembrane transporter activity
GPY18_RS21095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY18_RS21095	COG2146	nitrite reductase [NAD(P)H] activity
GPY18_RS21105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY18_RS21110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY18_RS21120	COG2226	methyltransferase
GPY18_RS21125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY18_RS21130	COG0501	Belongs to the peptidase M48B family
GPY18_RS21140	COG1028	Short-chain dehydrogenase reductase Sdr
GPY18_RS21155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY18_RS21175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY18_RS21180	COG2915	High frequency lysogenization protein hflD homolog
GPY18_RS21185	COG0482	sulfurtransferase activity
GPY18_RS21190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY18_RS21195	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY18_RS21200	COG1757	Na H antiporter
GPY18_RS21210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY18_RS21215	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY18_RS21220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY18_RS21225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY18_RS21225	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY18_RS21230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY18_RS21235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY18_RS21245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY18_RS21245	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY18_RS21250	COG1187	pseudouridine synthase activity
GPY18_RS21260	COG1278	Cold shock
GPY18_RS21265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY18_RS21270	COG0542	response to heat
GPY18_RS21275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY18_RS21280	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY18_RS21285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY18_RS21295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY18_RS21305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY18_RS21310	COG0745	RESPONSE REGULATOR receiver
GPY18_RS21310	COG3706	GGDEF domain
GPY18_RS21315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY18_RS21320	COG0297	glycogen (starch) synthase activity
GPY18_RS21340	COG3070	regulator of competence-specific genes
GPY18_RS21345	COG1609	Transcriptional regulator
GPY18_RS21350	COG3381	protein complex oligomerization
GPY18_RS21355	COG0745	RESPONSE REGULATOR receiver
GPY18_RS21360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY18_RS21365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY18_RS21370	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY18_RS21375	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY18_RS21380	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY18_RS21385	COG0189	ligase activity
GPY18_RS21395	COG0189	ligase activity
GPY18_RS21395	COG4067	protein conserved in archaea
GPY18_RS21400	COG0500	methyltransferase
GPY18_RS21405	COG4106	trans-aconitate 2-methyltransferase activity
GPY18_RS21420	COG1435	thymidine kinase activity
GPY18_RS21425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY18_RS21430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY18_RS21450	COG2116	formate transmembrane transporter activity
GPY18_RS21455	COG0390	transport system, permease component
GPY18_RS21460	COG4459	periplasmic nitrate reductase
GPY18_RS21465	COG3005	denitrification pathway
GPY18_RS21470	COG0243	molybdopterin cofactor binding
GPY18_RS21490	COG1227	inorganic diphosphatase activity
GPY18_RS21505	COG4172	Belongs to the ABC transporter superfamily
GPY18_RS21515	COG4171	peptide transport system, permease
GPY18_RS21520	COG4168	peptide transport system, permease
GPY18_RS21530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY18_RS21535	COG1842	Phage shock protein A
GPY18_RS21550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY18_RS21565	COG0519	Catalyzes the synthesis of GMP from XMP
GPY18_RS21595	COG0626	cystathionine gamma-synthase activity
GPY18_RS21605	COG0733	neurotransmitter:sodium symporter activity