locus-tag	class	description
GPY22_RS00010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY22_RS00020	COG1757	Na H antiporter
GPY22_RS00030	COG1643	Atp-dependent helicase
GPY22_RS00035	COG0281	malic enzyme
GPY22_RS00060	COG0583	DNA-binding transcription factor activity
GPY22_RS00075	COG0640	Transcriptional regulator
GPY22_RS00100	COG2949	membrane
GPY22_RS00110	COG1414	Transcriptional regulator
GPY22_RS00115	COG1414	Transcriptional regulator
GPY22_RS00125	COG1454	alcohol dehydrogenase
GPY22_RS00150	COG0492	ferredoxin-NADP+ reductase activity
GPY22_RS00170	COG1187	pseudouridine synthase activity
GPY22_RS00175	COG0009	L-threonylcarbamoyladenylate synthase
GPY22_RS00180	COG0613	PHP domain protein
GPY22_RS00195	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY22_RS00200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY22_RS00205	COG0134	indole-3-glycerol-phosphate synthase activity
GPY22_RS00205	COG0135	phosphoribosylanthranilate isomerase activity
GPY22_RS00210	COG0133	tryptophan synthase activity
GPY22_RS00220	COG1301	dicarboxylic acid transport
GPY22_RS00235	COG1607	acyl-coa hydrolase
GPY22_RS00240	COG2350	Protein conserved in bacteria
GPY22_RS00255	COG0583	DNA-binding transcription factor activity
GPY22_RS00340	COG5484	DNA packaging
GPY22_RS00340	COG3728	DNA packaging
GPY22_RS00360	COG3772	lysozyme
GPY22_RS00430	COG1484	DNA-dependent DNA replication
GPY22_RS00525	COG2974	May be involved in recombination
GPY22_RS00540	COG0582	viral genome integration into host DNA
GPY22_RS00575	COG0625	glutathione transferase activity
GPY22_RS00590	COG0840	transmembrane signaling receptor activity
GPY22_RS00605	COG1794	racemase activity, acting on amino acids and derivatives
GPY22_RS00610	COG0346	lactoylglutathione lyase activity
GPY22_RS00615	COG5002	protein histidine kinase activity
GPY22_RS00620	COG0745	RESPONSE REGULATOR receiver
GPY22_RS00640	COG0488	(ABC) transporter
GPY22_RS00645	COG1032	radical SAM domain protein
GPY22_RS00650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY22_RS00660	COG3852	Histidine kinase
GPY22_RS00675	COG3070	regulator of competence-specific genes
GPY22_RS00685	COG2431	L-lysine efflux transmembrane transporter activity
GPY22_RS00700	COG1737	Transcriptional regulator
GPY22_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS00705	COG1454	alcohol dehydrogenase
GPY22_RS00710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY22_RS00725	COG1960	acyl-CoA dehydrogenase activity
GPY22_RS00745	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS00770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY22_RS00775	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY22_RS00780	COG2885	chlorophyll binding
GPY22_RS00800	COG0811	peptide transport
GPY22_RS00815	COG4890	Cyd operon protein YbgT
GPY22_RS00825	COG1271	oxidase subunit
GPY22_RS00830	COG2255	four-way junction helicase activity
GPY22_RS00835	COG0632	four-way junction helicase activity
GPY22_RS00840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY22_RS00845	COG0215	cysteine-tRNA ligase activity
GPY22_RS00850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY22_RS00855	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY22_RS00860	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY22_RS00865	COG3012	SEC-C Motif Domain Protein
GPY22_RS00875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY22_RS00880	COG1199	ATP-dependent helicase activity
GPY22_RS00885	COG3923	Primosomal replication protein n
GPY22_RS00900	COG0708	Exodeoxyribonuclease III
GPY22_RS00910	COG4215	(ABC) transporter
GPY22_RS00930	COG1882	Formate acetyltransferase
GPY22_RS00945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY22_RS00965	COG2766	serine protein kinase
GPY22_RS00970	COG2718	Belongs to the UPF0229 family
GPY22_RS00975	COG2719	SpoVR family
GPY22_RS00980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY22_RS00995	COG1132	(ABC) transporter
GPY22_RS01000	COG0658	competence protein
GPY22_RS01000	COG2333	competence protein COMEC
GPY22_RS01010	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY22_RS01015	COG1136	(ABC) transporter
GPY22_RS01045	COG1252	NADH dehydrogenase
GPY22_RS01075	COG0537	adenosine 5'-monophosphoramidase activity
GPY22_RS01090	COG2186	Transcriptional regulator
GPY22_RS01095	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY22_RS01100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY22_RS01110	COG1522	sequence-specific DNA binding
GPY22_RS01115	COG0686	Belongs to the AlaDH PNT family
GPY22_RS01125	COG0583	DNA-binding transcription factor activity
GPY22_RS01145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY22_RS01150	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY22_RS01165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY22_RS01170	COG1555	photosystem II stabilization
GPY22_RS01180	COG0776	regulation of translation
GPY22_RS01185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY22_RS01190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY22_RS01200	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY22_RS01205	COG4191	Histidine kinase
GPY22_RS01210	COG2204	response regulator
GPY22_RS01220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY22_RS01225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY22_RS01230	COG1404	Belongs to the peptidase S8 family
GPY22_RS01250	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY22_RS01255	COG1760	l-serine dehydratase
GPY22_RS01275	COG1716	ATPase activity
GPY22_RS01275	COG5001	Diguanylate cyclase
GPY22_RS01285	COG4589	Belongs to the CDS family
GPY22_RS01320	COG2197	response regulator
GPY22_RS01325	COG3851	Histidine kinase
GPY22_RS01330	COG2271	Major facilitator Superfamily
GPY22_RS01345	COG3842	ATPase activity
GPY22_RS01355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY22_RS01360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY22_RS01370	COG2951	lytic endotransglycosylase activity
GPY22_RS01375	COG3100	YcgL domain-containing protein
GPY22_RS01385	COG2894	cell division
GPY22_RS01390	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY22_RS01400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY22_RS01405	COG0318	PFAM AMP-dependent synthetase and ligase
GPY22_RS01425	COG1214	PFAM Peptidase M22, glycoprotease
GPY22_RS01440	COG0788	formyltetrahydrofolate deformylase activity
GPY22_RS01445	COG1902	pentaerythritol trinitrate reductase activity
GPY22_RS01445	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY22_RS01455	COG0252	asparaginase activity
GPY22_RS01460	COG3139	Protein of unknown function (DUF1315)
GPY22_RS01470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY22_RS01475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY22_RS01485	COG2226	methyltransferase
GPY22_RS01515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY22_RS01520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY22_RS01525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY22_RS01535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY22_RS01540	COG2832	Protein of unknown function (DUF454)
GPY22_RS01550	COG0745	RESPONSE REGULATOR receiver
GPY22_RS01555	COG0583	DNA-binding transcription factor activity
GPY22_RS01560	COG0778	Nitroreductase
GPY22_RS01565	COG1024	Enoyl-CoA hydratase
GPY22_RS01565	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY22_RS01570	COG0183	Belongs to the thiolase family
GPY22_RS01595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY22_RS01610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY22_RS01615	COG2982	Protein involved in outer membrane biogenesis
GPY22_RS01620	COG0572	uridine kinase
GPY22_RS01630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY22_RS01630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY22_RS01640	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY22_RS01650	COG0516	GMP reductase activity
GPY22_RS01650	COG0517	IMP dehydrogenase activity
GPY22_RS01655	COG3706	GGDEF domain
GPY22_RS01660	COG0314	molybdopterin synthase activity
GPY22_RS01665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY22_RS01670	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY22_RS01675	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY22_RS01680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY22_RS01685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY22_RS01690	COG2198	Histidine kinase
GPY22_RS01710	COG0582	viral genome integration into host DNA
GPY22_RS01715	COG2003	Belongs to the UPF0758 family
GPY22_RS01760	COG0583	DNA-binding transcription factor activity
GPY22_RS01770	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS01775	COG2814	Major facilitator Superfamily
GPY22_RS01785	COG1902	pentaerythritol trinitrate reductase activity
GPY22_RS01800	COG4657	Part of a membrane complex involved in electron transport
GPY22_RS01805	COG2878	Part of a membrane complex involved in electron transport
GPY22_RS01815	COG4658	electron transport chain
GPY22_RS01825	COG4660	Part of a membrane complex involved in electron transport
GPY22_RS01830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY22_RS01835	COG0346	lactoylglutathione lyase activity
GPY22_RS01850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY22_RS01855	COG2056	Na+-H+ antiporter family
GPY22_RS01860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY22_RS01865	COG1286	toxin biosynthetic process
GPY22_RS01870	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY22_RS01875	COG0285	dihydrofolate synthase activity
GPY22_RS01885	COG0101	tRNA pseudouridine synthase activity
GPY22_RS01895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY22_RS01900	COG2190	(PTS) system
GPY22_RS01900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY22_RS01900	COG1263	PTS System
GPY22_RS01905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY22_RS01910	COG1940	carbohydrate kinase activity
GPY22_RS01910	COG1846	Transcriptional regulator
GPY22_RS01920	COG0367	asparagine synthase
GPY22_RS01930	COG3104	oligopeptide transport
GPY22_RS01935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY22_RS01945	COG0326	Molecular chaperone. Has ATPase activity
GPY22_RS01950	COG3710	Transcriptional regulator
GPY22_RS01965	COG0622	Phosphoesterase
GPY22_RS01990	COG1090	epimerase
GPY22_RS01995	COG0300	oxidoreductase activity
GPY22_RS02005	COG3118	belongs to the thioredoxin family
GPY22_RS02010	COG0330	HflC and HflK could
GPY22_RS02020	COG0789	Transcriptional regulator
GPY22_RS02035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY22_RS02040	COG3115	cell septum assembly
GPY22_RS02045	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY22_RS02050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY22_RS02060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY22_RS02070	COG2190	(PTS) system
GPY22_RS02075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY22_RS02080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY22_RS02085	COG1702	phosphate starvation-inducible protein PhoH
GPY22_RS02090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY22_RS02095	COG4535	Mg2 and Co2 transporter CorC
GPY22_RS02100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY22_RS02105	COG2888	peptidyl-tyrosine sulfation
GPY22_RS02115	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY22_RS02120	COG1466	dna polymerase III delta subunit
GPY22_RS02125	COG0799	negative regulation of ribosome biogenesis
GPY22_RS02130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY22_RS02135	COG0768	penicillin binding
GPY22_RS02140	COG0772	Belongs to the SEDS family
GPY22_RS02150	COG1686	Belongs to the peptidase S11 family
GPY22_RS02155	COG2921	Belongs to the UPF0250 family
GPY22_RS02160	COG0321	lipoyl(octanoyl) transferase activity
GPY22_RS02165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY22_RS02175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY22_RS02190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY22_RS02215	COG0366	Alpha amylase catalytic
GPY22_RS02220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY22_RS02220	COG1263	PTS System
GPY22_RS02235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY22_RS02240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY22_RS02245	COG2011	ABC-type metal ion transport system permease component
GPY22_RS02265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY22_RS02265	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY22_RS02275	COG0745	RESPONSE REGULATOR receiver
GPY22_RS02275	COG3706	GGDEF domain
GPY22_RS02280	COG1611	Belongs to the LOG family
GPY22_RS02285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY22_RS02295	COG2363	Small membrane protein
GPY22_RS02305	COG0583	DNA-binding transcription factor activity
GPY22_RS02310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY22_RS02310	COG0301	tRNA thio-modification
GPY22_RS02320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY22_RS02330	COG0142	geranyltranstransferase activity
GPY22_RS02335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY22_RS02340	COG0564	pseudouridine synthase activity
GPY22_RS02345	COG3098	single-species biofilm formation
GPY22_RS02370	COG1671	Belongs to the UPF0178 family
GPY22_RS02375	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY22_RS02380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY22_RS02390	COG1720	tRNA m6t6A37 methyltransferase activity
GPY22_RS02395	COG0442	prolyl-tRNA aminoacylation
GPY22_RS02420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY22_RS02425	COG0590	tRNA wobble adenosine to inosine editing
GPY22_RS02430	COG0583	DNA-binding transcription factor activity
GPY22_RS02435	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY22_RS02440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPY22_RS02445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY22_RS02470	COG4969	Belongs to the N-Me-Phe pilin family
GPY22_RS02480	COG0443	Heat shock 70 kDa protein
GPY22_RS02490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY22_RS02495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY22_RS02500	COG0497	DNA recombination
GPY22_RS02505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY22_RS02510	COG2914	Belongs to the UPF0125 (RnfH) family
GPY22_RS02515	COG2867	negative regulation of translational initiation
GPY22_RS02520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY22_RS02530	COG0582	viral genome integration into host DNA
GPY22_RS02590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY22_RS02595	COG1115	amino acid carrier protein
GPY22_RS02605	COG1473	amidohydrolase
GPY22_RS02620	COG1584	GPR1 FUN34 yaaH family protein
GPY22_RS02630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY22_RS02630	COG0519	Catalyzes the synthesis of GMP from XMP
GPY22_RS02635	COG0516	GMP reductase activity
GPY22_RS02635	COG0517	IMP dehydrogenase activity
GPY22_RS02640	COG1570	exodeoxyribonuclease VII activity
GPY22_RS02655	COG1160	GTP binding
GPY22_RS02660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY22_RS02665	COG2976	Protein conserved in bacteria
GPY22_RS02680	COG1426	Protein conserved in bacteria
GPY22_RS02695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY22_RS02700	COG2975	iron-sulfur cluster assembly
GPY22_RS02705	COG0633	Ferredoxin
GPY22_RS02710	COG0443	Heat shock 70 kDa protein
GPY22_RS02725	COG0822	iron-sulfur transferase activity
GPY22_RS02735	COG1959	2 iron, 2 sulfur cluster binding
GPY22_RS02740	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY22_RS02745	COG0483	inositol monophosphate 1-phosphatase activity
GPY22_RS02755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY22_RS02760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY22_RS02765	COG1862	Preprotein translocase
GPY22_RS02770	COG0343	queuine tRNA-ribosyltransferase activity
GPY22_RS02775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY22_RS02780	COG0517	IMP dehydrogenase activity
GPY22_RS02790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY22_RS02800	COG0450	alkyl hydroperoxide reductase
GPY22_RS02815	COG0704	Plays a role in the regulation of phosphate uptake
GPY22_RS02820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY22_RS02830	COG0573	inorganic phosphate transmembrane transporter activity
GPY22_RS02840	COG0248	Ppx GppA phosphatase
GPY22_RS02850	COG5002	protein histidine kinase activity
GPY22_RS02855	COG0745	RESPONSE REGULATOR receiver
GPY22_RS02860	COG2974	May be involved in recombination
GPY22_RS02870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY22_RS02885	COG1595	DNA-templated transcription, initiation
GPY22_RS02895	COG3248	Nucleoside-binding outer membrane protein
GPY22_RS02900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY22_RS02905	COG0693	protein deglycase activity
GPY22_RS02910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY22_RS02920	COG2166	iron-sulfur cluster assembly
GPY22_RS02925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY22_RS02930	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY22_RS02940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY22_RS02940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY22_RS02955	COG1074	ATP-dependent DNA helicase activity
GPY22_RS02975	COG3141	response to X-ray
GPY22_RS02980	COG2171	N-acyltransferase activity
GPY22_RS02985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY22_RS03000	COG0189	ligase activity
GPY22_RS03000	COG0569	domain protein
GPY22_RS03015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY22_RS03020	COG2017	converts alpha-aldose to the beta-anomer
GPY22_RS03035	COG3437	response regulator, receiver
GPY22_RS03035	COG0784	Response regulator, receiver
GPY22_RS03085	COG4964	Belongs to the GSP D family
GPY22_RS03135	COG0583	DNA-binding transcription factor activity
GPY22_RS03140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY22_RS03145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY22_RS03155	COG0560	Phosphoserine phosphatase
GPY22_RS03170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY22_RS03175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY22_RS03180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY22_RS03215	COG3022	response to hydroperoxide
GPY22_RS03220	COG1115	amino acid carrier protein
GPY22_RS03235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY22_RS03250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY22_RS03255	COG0083	homoserine kinase activity
GPY22_RS03270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY22_RS03285	COG0745	RESPONSE REGULATOR receiver
GPY22_RS03300	COG2203	Gaf domain
GPY22_RS03300	COG3706	GGDEF domain
GPY22_RS03300	COG4251	negative regulation of phosphorylation
GPY22_RS03300	COG5001	Diguanylate cyclase
GPY22_RS03305	COG1242	4 iron, 4 sulfur cluster binding
GPY22_RS03310	COG0070	glutamate synthase
GPY22_RS03310	COG0069	glutamate synthase activity
GPY22_RS03310	COG0067	glutamate synthase
GPY22_RS03325	COG0493	'glutamate synthase
GPY22_RS03350	COG2860	membrane
GPY22_RS03370	COG0583	DNA-binding transcription factor activity
GPY22_RS03375	COG0730	response to heat
GPY22_RS03385	COG0505	Belongs to the CarA family
GPY22_RS03395	COG0494	nUDIX hydrolase
GPY22_RS03400	COG0653	protein targeting
GPY22_RS03410	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY22_RS03415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY22_RS03420	COG0849	cell division
GPY22_RS03425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY22_RS03430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY22_RS03435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY22_RS03440	COG0772	Belongs to the SEDS family
GPY22_RS03445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY22_RS03455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY22_RS03460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY22_RS03465	COG0768	penicillin binding
GPY22_RS03470	COG3116	cell division
GPY22_RS03475	COG0275	rRNA processing
GPY22_RS03485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY22_RS03490	COG3107	peptidoglycan biosynthetic process
GPY22_RS03495	COG0792	nuclease activity
GPY22_RS03500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY22_RS03505	COG2823	Periplasmic or secreted lipoprotein
GPY22_RS03510	COG2969	positive regulation of protein catabolic process
GPY22_RS03515	COG0625	glutathione transferase activity
GPY22_RS03520	COG2857	Cytochrome c1
GPY22_RS03525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY22_RS03535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY22_RS03540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY22_RS03550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY22_RS03555	COG3105	Protein conserved in bacteria
GPY22_RS03560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY22_RS03565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY22_RS03570	COG0335	large ribosomal subunit rRNA binding
GPY22_RS03580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY22_RS03590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY22_RS03595	COG4137	Cytochrome C assembly protein
GPY22_RS03600	COG4536	flavin adenine dinucleotide binding
GPY22_RS03605	COG1854	S-ribosylhomocysteine lyase activity
GPY22_RS03625	COG1238	metal cluster binding
GPY22_RS03630	COG1063	alcohol dehydrogenase
GPY22_RS03635	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY22_RS03640	COG5016	pyruvate
GPY22_RS03640	COG0511	ligase activity, forming carbon-carbon bonds
GPY22_RS03645	COG3630	sodium ion export across plasma membrane
GPY22_RS03695	COG0527	aspartate kinase activity
GPY22_RS03700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY22_RS03710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY22_RS03715	COG1546	Belongs to the CinA family
GPY22_RS03725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY22_RS03730	COG1388	LysM domain
GPY22_RS03730	COG4942	peptidase
GPY22_RS03740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY22_RS03745	COG0585	pseudouridine synthase activity
GPY22_RS03755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY22_RS03760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY22_RS03765	COG1968	undecaprenyl-diphosphatase activity
GPY22_RS03770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY22_RS03775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY22_RS03780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY22_RS03795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY22_RS03800	COG1610	YqeY-like protein
GPY22_RS03810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY22_RS03830	COG3206	protein involved in exopolysaccharide biosynthesis
GPY22_RS03830	COG0489	protein tyrosine kinase activity
GPY22_RS03855	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY22_RS03865	COG1349	DNA-binding transcription factor activity
GPY22_RS03875	COG3706	GGDEF domain
GPY22_RS03900	COG0668	transmembrane transport
GPY22_RS03905	COG0191	fructose-bisphosphate aldolase activity
GPY22_RS03910	COG0126	phosphoglycerate kinase activity
GPY22_RS03915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY22_RS03920	COG4771	TonB-dependent receptor
GPY22_RS03925	COG0583	DNA-binding transcription factor activity
GPY22_RS03930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY22_RS03950	COG2356	endonuclease I
GPY22_RS03955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY22_RS03960	COG0189	ligase activity
GPY22_RS03965	COG1678	Uncharacterized ACR, COG1678
GPY22_RS03970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY22_RS03990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY22_RS03995	COG0762	integral membrane protein
GPY22_RS04000	COG1872	DUF167
GPY22_RS04015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY22_RS04020	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY22_RS04025	COG2066	Belongs to the glutaminase family
GPY22_RS04030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY22_RS04035	COG1194	a g-specific adenine glycosylase
GPY22_RS04040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY22_RS04045	COG0741	lytic transglycosylase activity
GPY22_RS04070	COG0840	transmembrane signaling receptor activity
GPY22_RS04100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY22_RS04105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY22_RS04110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY22_RS04125	COG2967	ApaG domain
GPY22_RS04130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY22_RS04140	COG3610	response to peptide
GPY22_RS04145	COG2966	Psort location CytoplasmicMembrane, score
GPY22_RS04150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY22_RS04155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY22_RS04160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY22_RS04170	COG0531	amino acid
GPY22_RS04175	COG0039	L-malate dehydrogenase activity
GPY22_RS04195	COG0589	response to stress
GPY22_RS04215	COG0312	modulator of DNA gyrase
GPY22_RS04220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY22_RS04225	COG3164	Protein of unknown function
GPY22_RS04230	COG1530	ribonuclease E activity
GPY22_RS04235	COG0424	maF-like protein
GPY22_RS04240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY22_RS04245	COG1792	Involved in formation and maintenance of cell shape
GPY22_RS04250	COG1077	Cell shape determining protein MreB Mrl
GPY22_RS04305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY22_RS04315	COG3267	Type II secretory pathway component ExeA
GPY22_RS04315	COG3409	Peptidoglycan-binding domain 1 protein
GPY22_RS04340	COG2199	diguanylate cyclase activity
GPY22_RS04340	COG2200	EAL domain
GPY22_RS04345	COG0629	single-stranded DNA binding
GPY22_RS04370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY22_RS04375	COG0527	aspartate kinase activity
GPY22_RS04380	COG0646	methionine synthase
GPY22_RS04380	COG1410	methionine synthase
GPY22_RS04450	COG0175	sulfate reduction
GPY22_RS04460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY22_RS04480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY22_RS04485	COG0735	belongs to the Fur family
GPY22_RS04495	COG0166	Belongs to the GPI family
GPY22_RS04500	COG0432	Pfam Uncharacterised protein family UPF0047
GPY22_RS04505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY22_RS04520	COG0359	binds to the 23S rRNA
GPY22_RS04530	COG2965	DNA replication, synthesis of RNA primer
GPY22_RS04535	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY22_RS04545	COG2906	2 iron, 2 sulfur cluster binding
GPY22_RS04555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY22_RS04560	COG0049	tRNA binding
GPY22_RS04570	COG2168	tRNA wobble position uridine thiolation
GPY22_RS04575	COG2923	Belongs to the DsrF TusC family
GPY22_RS04585	COG2964	Protein conserved in bacteria
GPY22_RS04590	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY22_RS04600	COG2900	Belongs to the SlyX family
GPY22_RS04605	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY22_RS04610	COG0330	HflC and HflK could
GPY22_RS04625	COG1923	regulation of RNA biosynthetic process
GPY22_RS04645	COG0802	atpase or kinase
GPY22_RS04650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY22_RS04705	COG1162	GTPase activity
GPY22_RS04710	COG0688	phosphatidylethanolamine metabolic process
GPY22_RS04715	COG0471	metal ion transport
GPY22_RS04715	COG0490	domain, Protein
GPY22_RS04730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY22_RS04755	COG2816	NAD+ diphosphatase activity
GPY22_RS04760	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY22_RS04765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY22_RS04780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY22_RS04785	COG0081	regulation of translation
GPY22_RS04790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY22_RS04795	COG0250	Participates in transcription elongation, termination and antitermination
GPY22_RS04800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY22_RS04830	COG1072	(Pantothenic acid kinase))
GPY22_RS04840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY22_RS04850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY22_RS04915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY22_RS04925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY22_RS04930	COG3118	belongs to the thioredoxin family
GPY22_RS04935	COG0513	Belongs to the DEAD box helicase family
GPY22_RS04940	COG0248	Ppx GppA phosphatase
GPY22_RS04945	COG0784	Response regulator, receiver
GPY22_RS04945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY22_RS04945	COG2198	Histidine kinase
GPY22_RS04945	COG2205	protein histidine kinase activity
GPY22_RS04950	COG2814	Major facilitator Superfamily
GPY22_RS04970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY22_RS04975	COG0511	ligase activity, forming carbon-carbon bonds
GPY22_RS04980	COG0439	Biotin carboxylase
GPY22_RS04985	COG2264	protein methyltransferase activity
GPY22_RS04995	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY22_RS05005	COG0789	Transcriptional regulator
GPY22_RS05015	COG0138	bifunctional purine biosynthesis protein purh
GPY22_RS05030	COG0776	regulation of translation
GPY22_RS05040	COG0668	transmembrane transport
GPY22_RS05045	COG3068	Protein conserved in bacteria
GPY22_RS05050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY22_RS05055	COG1573	uracil-dna glycosylase
GPY22_RS05060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY22_RS05065	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GPY22_RS05120	COG0367	asparagine synthase
GPY22_RS05150	COG2089	acid synthase
GPY22_RS05160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY22_RS05170	COG1560	Kdo2-lipid A biosynthetic process
GPY22_RS05180	COG0859	PFAM glycosyl transferase family 9
GPY22_RS05185	COG0859	PFAM glycosyl transferase family 9
GPY22_RS05190	COG1519	Transferase
GPY22_RS05195	COG0438	transferase activity, transferring glycosyl groups
GPY22_RS05205	COG0859	PFAM glycosyl transferase family 9
GPY22_RS05210	COG0463	Glycosyl transferase, family 2
GPY22_RS05215	COG0438	transferase activity, transferring glycosyl groups
GPY22_RS05220	COG0438	transferase activity, transferring glycosyl groups
GPY22_RS05225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY22_RS05240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY22_RS05250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY22_RS05270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY22_RS05280	COG1560	Kdo2-lipid A biosynthetic process
GPY22_RS05285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY22_RS05290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY22_RS05295	COG1561	YicC-like family, N-terminal region
GPY22_RS05315	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY22_RS05320	COG1120	ATPase activity
GPY22_RS05325	COG1132	(ABC) transporter
GPY22_RS05340	COG0514	ATP-dependent DNA helicase (RecQ)
GPY22_RS05345	COG2962	Rard protein
GPY22_RS05355	COG1280	lysine exporter protein (LysE YggA)
GPY22_RS05365	COG0210	DNA helicase
GPY22_RS05400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY22_RS05405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY22_RS05420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY22_RS05435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY22_RS05445	COG0747	negative chemotaxis
GPY22_RS05450	COG4172	Belongs to the ABC transporter superfamily
GPY22_RS05485	COG0210	DNA helicase
GPY22_RS05495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY22_RS05500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY22_RS05515	COG0583	DNA-binding transcription factor activity
GPY22_RS05560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY22_RS05570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY22_RS05575	COG0408	coproporphyrinogen oxidase activity
GPY22_RS05590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY22_RS05595	COG0551	DNA topoisomerase type I activity
GPY22_RS05600	COG2922	Belongs to the Smg family
GPY22_RS05605	COG0758	DNA mediated transformation
GPY22_RS05615	COG0242	peptide deformylase activity
GPY22_RS05625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY22_RS05625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY22_RS05630	COG0569	domain protein
GPY22_RS05635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY22_RS05645	COG1272	protein, Hemolysin III
GPY22_RS05650	COG4326	sporulation control protein
GPY22_RS05660	COG3084	Protein conserved in bacteria
GPY22_RS05670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY22_RS05675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY22_RS05680	COG0204	Acyl-transferase
GPY22_RS05685	COG0606	chelatase, subunit chli
GPY22_RS05695	COG3978	acetolactate synthase activity
GPY22_RS05700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY22_RS05740	COG2119	membrane
GPY22_RS05745	COG0752	glycyl-tRNA synthetase alpha subunit
GPY22_RS05750	COG0751	glycine-tRNA ligase activity
GPY22_RS05755	COG3977	Valine--pyruvate aminotransferase
GPY22_RS05760	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY22_RS05765	COG0187	DNA topoisomerase II activity
GPY22_RS05770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY22_RS05775	COG0592	DNA-directed DNA polymerase activity
GPY22_RS05780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY22_RS05795	COG1126	abc transporter atp-binding protein
GPY22_RS05800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY22_RS05810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY22_RS05815	COG0706	membrane insertase activity
GPY22_RS05820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY22_RS05830	COG0445	tRNA wobble uridine modification
GPY22_RS05835	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY22_RS05840	COG1192	Involved in chromosome partitioning
GPY22_RS05845	COG1475	DNA binding
GPY22_RS05850	COG3312	ion transport
GPY22_RS05855	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY22_RS05865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY22_RS05870	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY22_RS05880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY22_RS05885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY22_RS05890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY22_RS05900	COG0765	amino acid transport
GPY22_RS05905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY22_RS05910	COG2814	Major facilitator Superfamily
GPY22_RS05915	COG0583	DNA-binding transcription factor activity
GPY22_RS05920	COG0183	Belongs to the thiolase family
GPY22_RS05930	COG1739	Uncharacterized protein family UPF0029
GPY22_RS06005	COG0352	thiamine-phosphate diphosphorylase activity
GPY22_RS06010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY22_RS06015	COG2104	thiamine diphosphate biosynthetic process
GPY22_RS06015	COG2022	thiamine diphosphate biosynthetic process
GPY22_RS06030	COG0517	IMP dehydrogenase activity
GPY22_RS06030	COG4175	Glycine betaine
GPY22_RS06060	COG0006	proline dipeptidase activity
GPY22_RS06060	COG0006	proline dipeptidase activity
GPY22_RS06080	COG1522	sequence-specific DNA binding
GPY22_RS06105	COG0589	response to stress
GPY22_RS06110	COG1528	Iron-storage protein
GPY22_RS06120	COG2081	HI0933 family
GPY22_RS06125	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY22_RS06130	COG1129	ABC transporter
GPY22_RS06135	COG1879	ABC-type sugar transport system periplasmic component
GPY22_RS06140	COG1069	ribulokinase activity
GPY22_RS06145	COG0235	Class ii aldolase
GPY22_RS06150	COG2160	L-arabinose isomerase activity
GPY22_RS06175	COG1322	Protein conserved in bacteria
GPY22_RS06180	COG2226	methyltransferase
GPY22_RS06185	COG3165	ubiquinone biosynthetic process from chorismate
GPY22_RS06190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY22_RS06200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY22_RS06205	COG0805	protein transport
GPY22_RS06230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY22_RS06255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY22_RS06265	COG2959	enzyme of heme biosynthesis
GPY22_RS06280	COG3072	Adenylate cyclase
GPY22_RS06295	COG0019	diaminopimelate decarboxylase activity
GPY22_RS06300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY22_RS06310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY22_RS06315	COG1011	Hydrolase
GPY22_RS06320	COG2199	diguanylate cyclase activity
GPY22_RS06320	COG2200	EAL domain
GPY22_RS06320	COG3287	FIST C domain
GPY22_RS06340	COG0561	phosphatase activity
GPY22_RS06350	COG1280	lysine exporter protein (LysE YggA)
GPY22_RS06355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY22_RS06360	COG0640	Transcriptional regulator
GPY22_RS06365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY22_RS06380	COG0783	Belongs to the Dps family
GPY22_RS06410	COG2095	MarC family integral membrane protein
GPY22_RS06420	COG0742	ribosomal rna small subunit methyltransferase
GPY22_RS06430	COG2884	Cell division ATP-binding protein ftsE
GPY22_RS06435	COG2177	Part of the ABC transporter FtsEX involved in
GPY22_RS06440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY22_RS06450	COG0705	Rhomboid family
GPY22_RS06455	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY22_RS06460	COG3161	chorismate lyase activity
GPY22_RS06465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY22_RS06470	COG2937	Belongs to the GPAT DAPAT family
GPY22_RS06475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY22_RS06490	COG0534	Mate efflux family protein
GPY22_RS06510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY22_RS06525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPY22_RS06580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY22_RS06585	COG5001	Diguanylate cyclase
GPY22_RS06585	COG3300	MHYT domain
GPY22_RS06590	COG2204	response regulator
GPY22_RS06605	COG0174	glutamine synthetase
GPY22_RS06630	COG1490	D-aminoacyl-tRNA deacylase activity
GPY22_RS06635	COG0456	acetyltransferase
GPY22_RS06640	COG2982	Protein involved in outer membrane biogenesis
GPY22_RS06645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY22_RS06650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY22_RS06655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY22_RS06660	COG3031	protein transport across the cell outer membrane
GPY22_RS06670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY22_RS06675	COG1459	type II secretion system
GPY22_RS06680	COG2165	general secretion pathway protein
GPY22_RS06685	COG2165	general secretion pathway protein
GPY22_RS06690	COG2165	general secretion pathway protein
GPY22_RS06695	COG4795	General secretion pathway protein
GPY22_RS06700	COG3156	type II secretion system protein K
GPY22_RS06710	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY22_RS06725	COG0494	nUDIX hydrolase
GPY22_RS06730	COG0316	Belongs to the HesB IscA family
GPY22_RS06730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY22_RS06735	COG1040	competence protein
GPY22_RS06760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY22_RS06765	COG1609	Transcriptional regulator
GPY22_RS06770	COG0129	dihydroxy-acid dehydratase activity
GPY22_RS06775	COG3265	gluconokinase activity
GPY22_RS06780	COG2610	gluconate transmembrane transporter activity
GPY22_RS06785	COG0800	Aldolase
GPY22_RS06790	COG0745	RESPONSE REGULATOR receiver
GPY22_RS06795	COG2205	protein histidine kinase activity
GPY22_RS06800	COG2233	PERMEase
GPY22_RS06805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY22_RS06810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY22_RS06815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY22_RS06825	COG0194	GDP metabolic process
GPY22_RS06835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY22_RS06845	COG3263	regulation of cellular component size
GPY22_RS06855	COG4232	protein-disulfide reductase activity
GPY22_RS06865	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY22_RS06870	COG0540	Belongs to the ATCase OTCase family
GPY22_RS06875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY22_RS06890	COG1288	antiporter activity
GPY22_RS06895	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY22_RS06900	COG1027	Aspartate ammonia-lyase
GPY22_RS06905	COG3706	GGDEF domain
GPY22_RS06910	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY22_RS06915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY22_RS06920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GPY22_RS06925	COG2205	protein histidine kinase activity
GPY22_RS06930	COG0745	RESPONSE REGULATOR receiver
GPY22_RS06940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY22_RS06945	COG0205	6-phosphofructokinase activity
GPY22_RS06950	COG1494	fructose-1,6-bisphosphatase
GPY22_RS06960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY22_RS06965	COG0460	homoserine dehydrogenase
GPY22_RS06965	COG0527	aspartate kinase activity
GPY22_RS06970	COG0626	cystathionine gamma-synthase activity
GPY22_RS06985	COG0254	rRNA binding
GPY22_RS06990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY22_RS06995	COG1609	Transcriptional regulator
GPY22_RS07005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY22_RS07010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY22_RS07015	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY22_RS07020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY22_RS07030	COG0149	triose-phosphate isomerase activity
GPY22_RS07055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY22_RS07060	COG0459	protein refolding
GPY22_RS07065	COG1119	ATPase activity
GPY22_RS07075	COG1285	pathogenesis
GPY22_RS07080	COG1509	lysine 2,3-aminomutase activity
GPY22_RS07085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY22_RS07090	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY22_RS07095	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY22_RS07100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY22_RS07105	COG1053	succinate dehydrogenase
GPY22_RS07110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY22_RS07115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY22_RS07120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY22_RS07125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY22_RS07130	COG1045	serine acetyltransferase
GPY22_RS07135	COG1695	Transcriptional regulator
GPY22_RS07140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY22_RS07145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY22_RS07150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY22_RS07165	COG0165	Argininosuccinate lyase
GPY22_RS07165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY22_RS07175	COG0678	peroxiredoxin activity
GPY22_RS07175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY22_RS07185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY22_RS07230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY22_RS07235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY22_RS07245	COG0180	Tryptophanyl-tRNA synthetase
GPY22_RS07265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY22_RS07275	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS07285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY22_RS07290	COG3954	Phosphoribulokinase
GPY22_RS07300	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY22_RS07310	COG0488	(ABC) transporter
GPY22_RS07315	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY22_RS07325	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GPY22_RS07330	COG1047	Peptidyl-prolyl cis-trans
GPY22_RS07340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY22_RS07345	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY22_RS07350	COG3083	sulfuric ester hydrolase activity
GPY22_RS07355	COG0557	exoribonuclease II activity
GPY22_RS07360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY22_RS07365	COG0051	transcription antitermination factor activity, RNA binding
GPY22_RS07370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY22_RS07375	COG0088	Forms part of the polypeptide exit tunnel
GPY22_RS07380	COG0089	rRNA binding
GPY22_RS07390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY22_RS07395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY22_RS07410	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY22_RS07420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY22_RS07425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY22_RS07430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY22_RS07435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY22_RS07440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY22_RS07445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY22_RS07450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY22_RS07460	COG1841	ribosomal large subunit assembly
GPY22_RS07470	COG0201	protein transport
GPY22_RS07485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY22_RS07490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY22_RS07495	COG0202	RNA polymerase activity
GPY22_RS07500	COG0203	ribosomal protein L17
GPY22_RS07515	COG3061	Opacity-associated protein A
GPY22_RS07525	COG2153	protein acetylation
GPY22_RS07530	COG0513	Belongs to the DEAD box helicase family
GPY22_RS07545	COG1648	precorrin-2 dehydrogenase activity
GPY22_RS07545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY22_RS07550	COG0175	sulfate reduction
GPY22_RS07555	COG2895	sulfate adenylyltransferase (ATP) activity
GPY22_RS07560	COG0471	metal ion transport
GPY22_RS07560	COG0490	domain, Protein
GPY22_RS07565	COG0529	Catalyzes the synthesis of activated sulfate
GPY22_RS07585	COG1136	(ABC) transporter
GPY22_RS07585	COG0577	efflux transmembrane transporter activity
GPY22_RS07600	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY22_RS07605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY22_RS07620	COG2105	PFAM AIG2 family protein
GPY22_RS07625	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY22_RS07630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY22_RS07635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY22_RS07640	COG0163	prenyltransferase activity
GPY22_RS07645	COG4143	(ABC) transporter
GPY22_RS07650	COG1178	ABC-type Fe3 transport system permease component
GPY22_RS07655	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY22_RS07660	COG3028	Belongs to the UPF0307 family
GPY22_RS07665	COG0312	modulator of DNA gyrase
GPY22_RS07675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY22_RS07685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY22_RS07690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY22_RS07700	COG1137	ATPase activity
GPY22_RS07705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY22_RS07715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GPY22_RS07720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY22_RS07720	COG0517	IMP dehydrogenase activity
GPY22_RS07735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY22_RS07740	COG2854	intermembrane phospholipid transfer
GPY22_RS07745	COG3113	response to antibiotic
GPY22_RS07750	COG5007	Belongs to the BolA IbaG family
GPY22_RS07755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY22_RS07760	COG0204	Acyl-transferase
GPY22_RS07765	COG0251	oxidation-reduction process
GPY22_RS07770	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY22_RS07775	COG0540	Belongs to the ATCase OTCase family
GPY22_RS07780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY22_RS07785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY22_RS07805	COG0564	pseudouridine synthase activity
GPY22_RS07810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY22_RS07815	COG0525	valine-tRNA ligase activity
GPY22_RS07830	COG0795	lipopolysaccharide-transporting ATPase activity
GPY22_RS07835	COG0795	lipopolysaccharide-transporting ATPase activity
GPY22_RS07845	COG3706	GGDEF domain
GPY22_RS07865	COG2199	diguanylate cyclase activity
GPY22_RS07865	COG2200	EAL domain
GPY22_RS07865	COG2203	Gaf domain
GPY22_RS07875	COG3437	response regulator, receiver
GPY22_RS07925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY22_RS07930	COG0473	3-isopropylmalate dehydrogenase activity
GPY22_RS07935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY22_RS07955	COG0583	DNA-binding transcription factor activity
GPY22_RS07960	COG1022	Amp-dependent synthetase and ligase
GPY22_RS07965	COG0028	Belongs to the TPP enzyme family
GPY22_RS07970	COG0440	acetolactate synthase activity
GPY22_RS07985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY22_RS07995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY22_RS08005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY22_RS08010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY22_RS08025	COG0354	folic acid binding
GPY22_RS08030	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY22_RS08040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY22_RS08060	COG3086	response to oxidative stress
GPY22_RS08065	COG0481	GTPase activity
GPY22_RS08070	COG0681	Belongs to the peptidase S26 family
GPY22_RS08080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY22_RS08085	COG1381	Involved in DNA repair and RecF pathway recombination
GPY22_RS08090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY22_RS08095	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY22_RS08105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY22_RS08110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY22_RS08115	COG3956	TIGRFAM MazG family protein
GPY22_RS08120	COG0504	CTP synthase activity
GPY22_RS08125	COG0148	phosphopyruvate hydratase activity
GPY22_RS08130	COG0617	tRNA 3'-terminal CCA addition
GPY22_RS08150	COG0306	phosphate transporter
GPY22_RS08155	COG1392	Phosphate transport regulator
GPY22_RS08165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY22_RS08175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY22_RS08180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY22_RS08180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY22_RS08185	COG1538	Outer membrane efflux protein
GPY22_RS08190	COG0494	nUDIX hydrolase
GPY22_RS08195	COG3151	Protein conserved in bacteria
GPY22_RS08205	COG3150	esterase
GPY22_RS08210	COG0187	DNA topoisomerase II activity
GPY22_RS08215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY22_RS08220	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY22_RS08225	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY22_RS08240	COG1459	type II secretion system
GPY22_RS08265	COG0716	FMN binding
GPY22_RS08275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY22_RS08280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY22_RS08285	COG2186	Transcriptional regulator
GPY22_RS08290	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY22_RS08315	COG0288	reversible hydration of carbon dioxide
GPY22_RS08320	COG1131	(ABC) transporter
GPY22_RS08330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY22_RS08335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY22_RS08340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY22_RS08350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY22_RS08355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY22_RS08365	COG1643	Atp-dependent helicase
GPY22_RS08370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY22_RS08375	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY22_RS08385	COG3112	Uncharacterised protein family (UPF0231)
GPY22_RS08390	COG0347	Belongs to the P(II) protein family
GPY22_RS08395	COG0004	ammonium transporteR
GPY22_RS08400	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY22_RS08410	COG3842	ATPase activity
GPY22_RS08415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY22_RS08430	COG2971	BadF BadG BcrA BcrD
GPY22_RS08440	COG4608	Belongs to the ABC transporter superfamily
GPY22_RS08450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY22_RS08475	COG0628	permease
GPY22_RS08480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY22_RS08485	COG0316	Belongs to the HesB IscA family
GPY22_RS08505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY22_RS08515	COG2239	Acts as a magnesium transporter
GPY22_RS08520	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY22_RS08525	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY22_RS08530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY22_RS08545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY22_RS08550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY22_RS08555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY22_RS08560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY22_RS08575	COG0779	Required for maturation of 30S ribosomal subunits
GPY22_RS08590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY22_RS08620	COG0534	Mate efflux family protein
GPY22_RS08645	COG3153	acetyltransferase
GPY22_RS08665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY22_RS08670	COG0513	Belongs to the DEAD box helicase family
GPY22_RS08695	COG2204	response regulator
GPY22_RS08705	COG0667	Aldo Keto reductase
GPY22_RS08715	COG3066	DNA modification
GPY22_RS08720	COG0494	nUDIX hydrolase
GPY22_RS08730	COG0730	response to heat
GPY22_RS08740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY22_RS08745	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY22_RS08750	COG0583	DNA-binding transcription factor activity
GPY22_RS08755	COG0640	Transcriptional regulator
GPY22_RS08770	COG0196	riboflavin kinase activity
GPY22_RS08775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY22_RS08780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY22_RS08785	COG1047	Peptidyl-prolyl cis-trans
GPY22_RS08790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY22_RS08795	COG1966	Carbon starvation protein
GPY22_RS08810	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY22_RS08815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY22_RS08825	COG3279	Response regulator of the LytR AlgR family
GPY22_RS08830	COG3275	phosphorelay sensor kinase activity
GPY22_RS08835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY22_RS08850	COG0488	(ABC) transporter
GPY22_RS08865	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY22_RS08870	COG5001	Diguanylate cyclase
GPY22_RS08875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY22_RS08880	COG0077	Prephenate dehydratase
GPY22_RS08880	COG1605	Chorismate mutase
GPY22_RS08885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY22_RS08890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY22_RS08895	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY22_RS08900	COG0564	pseudouridine synthase activity
GPY22_RS08910	COG0542	response to heat
GPY22_RS08920	COG0590	tRNA wobble adenosine to inosine editing
GPY22_RS08925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY22_RS08930	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GPY22_RS09015	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY22_RS09020	COG1805	sodium ion transport
GPY22_RS09030	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY22_RS09035	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY22_RS09040	COG2871	sodium ion transport
GPY22_RS09045	COG1477	protein flavinylation
GPY22_RS09060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY22_RS09075	COG0733	neurotransmitter:sodium symporter activity
GPY22_RS09085	COG0189	ligase activity
GPY22_RS09090	COG0189	ligase activity
GPY22_RS09090	COG4067	protein conserved in archaea
GPY22_RS09095	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY22_RS09100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY22_RS09105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY22_RS09115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY22_RS09125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY22_RS09130	COG2252	PERMEase
GPY22_RS09135	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY22_RS09150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY22_RS09155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY22_RS09160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY22_RS09165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY22_RS09165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY22_RS09185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY22_RS09190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY22_RS09210	COG0024	Methionine aminopeptidase
GPY22_RS09240	COG0575	Belongs to the CDS family
GPY22_RS09245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY22_RS09250	COG0750	zinc metalloprotease
GPY22_RS09260	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY22_RS09265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY22_RS09280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY22_RS09290	COG0587	DNA-directed DNA polymerase activity
GPY22_RS09295	COG0825	malonyl-CoA metabolic process
GPY22_RS09300	COG0037	tRNA processing
GPY22_RS09310	COG0347	Belongs to the P(II) protein family
GPY22_RS09325	COG1388	LysM domain
GPY22_RS09325	COG0741	lytic transglycosylase activity
GPY22_RS09335	COG2226	methyltransferase
GPY22_RS09340	COG0328	RNA-DNA hybrid ribonuclease activity
GPY22_RS09345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY22_RS09360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY22_RS09365	COG0121	glutamine amidotransferase
GPY22_RS09370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY22_RS09380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY22_RS09385	COG1187	pseudouridine synthase activity
GPY22_RS09390	COG2840	Smr protein MutS2
GPY22_RS09420	COG2217	Heavy metal translocating P-type atpase
GPY22_RS09420	COG2608	mercury ion transmembrane transporter activity
GPY22_RS09425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY22_RS09445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY22_RS09545	COG4695	Portal protein
GPY22_RS09575	COG2747	anti-sigma28 factor FlgM
GPY22_RS09585	COG0835	chemotaxis
GPY22_RS09585	COG0784	Response regulator, receiver
GPY22_RS09590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY22_RS09595	COG1815	bacterial-type flagellum-dependent cell motility
GPY22_RS09600	COG1558	bacterial-type flagellum-dependent cell motility
GPY22_RS09605	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY22_RS09610	COG1749	Flagellar hook protein flgE
GPY22_RS09615	COG4787	bacterial-type flagellum-dependent cell motility
GPY22_RS09620	COG4786	Flagellar basal body rod
GPY22_RS09625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY22_RS09635	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY22_RS09635	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY22_RS09650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY22_RS09750	COG0193	aminoacyl-tRNA hydrolase activity
GPY22_RS09755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY22_RS09765	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY22_RS09770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY22_RS09775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY22_RS09780	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY22_RS09785	COG3094	Invasion gene expression up-regulator, SirB
GPY22_RS09790	COG2912	Transglutaminase-like superfamily
GPY22_RS09800	COG0737	Belongs to the 5'-nucleotidase family
GPY22_RS09830	COG1393	Belongs to the ArsC family
GPY22_RS09855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY22_RS09860	COG2716	regulation of RNA biosynthetic process
GPY22_RS09865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY22_RS09870	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY22_RS09885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY22_RS09890	COG1393	Belongs to the ArsC family
GPY22_RS09910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPY22_RS09940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY22_RS09950	COG1334	flagellar protein FlaG
GPY22_RS09955	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY22_RS09965	COG1516	flagellar protein fliS
GPY22_RS09970	COG2204	response regulator
GPY22_RS09975	COG4191	Histidine kinase
GPY22_RS09980	COG2204	response regulator
GPY22_RS09985	COG1677	Flagellar hook-basal body complex protein FliE
GPY22_RS09995	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY22_RS10045	COG1987	bacterial-type flagellum assembly
GPY22_RS10070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY22_RS10075	COG0583	DNA-binding transcription factor activity
GPY22_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS10085	COG2860	membrane
GPY22_RS10090	COG3101	peptidyl-lysine hydroxylation
GPY22_RS10110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY22_RS10115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY22_RS10125	COG0735	belongs to the Fur family
GPY22_RS10135	COG0583	DNA-binding transcription factor activity
GPY22_RS10140	COG1380	Effector of murein hydrolase LrgA
GPY22_RS10145	COG1346	cytolysis
GPY22_RS10160	COG0596	Alpha beta hydrolase
GPY22_RS10165	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY22_RS10170	COG0033	Phosphoglucomutase
GPY22_RS10180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY22_RS10190	COG2009	succinate dehydrogenase
GPY22_RS10195	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY22_RS10210	COG0567	Dehydrogenase, E1 component
GPY22_RS10215	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY22_RS10235	COG1121	(ABC) transporter
GPY22_RS10240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY22_RS10250	COG1918	ferrous iron import across plasma membrane
GPY22_RS10270	COG0018	arginyl-trna synthetase
GPY22_RS10275	COG3102	Protein conserved in bacteria
GPY22_RS10285	COG2062	phosphohistidine phosphatase, SixA
GPY22_RS10300	COG0455	bacterial-type flagellum organization
GPY22_RS10315	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY22_RS10320	COG0643	Histidine kinase
GPY22_RS10320	COG2198	Histidine kinase
GPY22_RS10325	COG2201	protein-glutamate methylesterase activity
GPY22_RS10330	COG1192	Involved in chromosome partitioning
GPY22_RS10340	COG0835	chemotaxis
GPY22_RS10350	COG4133	protoheme IX ABC transporter activity
GPY22_RS10355	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY22_RS10360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY22_RS10365	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY22_RS10370	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY22_RS10375	COG1138	Cytochrome C-type biogenesis protein
GPY22_RS10380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY22_RS10395	COG2853	Lipoprotein
GPY22_RS10415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY22_RS10425	COG3384	dioxygenase
GPY22_RS10450	COG0667	Aldo Keto reductase
GPY22_RS10465	COG0583	DNA-binding transcription factor activity
GPY22_RS10470	COG2159	amidohydrolase
GPY22_RS10475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY22_RS10515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY22_RS10530	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY22_RS10555	COG3083	sulfuric ester hydrolase activity
GPY22_RS10565	COG3081	Nucleoid-associated protein
GPY22_RS10575	COG1757	Na H antiporter
GPY22_RS10580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY22_RS10585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY22_RS10590	COG2095	MarC family integral membrane protein
GPY22_RS10595	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS10595	COG1454	alcohol dehydrogenase
GPY22_RS10605	COG0659	secondary active sulfate transmembrane transporter activity
GPY22_RS10620	COG0564	pseudouridine synthase activity
GPY22_RS10625	COG0424	maF-like protein
GPY22_RS10630	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY22_RS10640	COG0416	fatty acid biosynthetic process
GPY22_RS10645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY22_RS10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY22_RS10670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY22_RS10675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY22_RS10680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY22_RS10685	COG0470	DNA polymerase III
GPY22_RS10690	COG0084	hydrolase, TatD family'
GPY22_RS10695	COG2190	(PTS) system
GPY22_RS10695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY22_RS10695	COG1263	PTS System
GPY22_RS10705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY22_RS10705	COG1263	PTS System
GPY22_RS10720	COG0733	neurotransmitter:sodium symporter activity
GPY22_RS10735	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY22_RS10745	COG1940	carbohydrate kinase activity
GPY22_RS10750	COG0784	Response regulator, receiver
GPY22_RS10750	COG0835	chemotaxis
GPY22_RS10755	COG0587	DNA-directed DNA polymerase activity
GPY22_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS10775	COG0616	signal peptide processing
GPY22_RS10790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPY22_RS10790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY22_RS10810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY22_RS10815	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY22_RS10820	COG0436	Aminotransferase
GPY22_RS10825	COG1169	isochorismate synthase
GPY22_RS10830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY22_RS10835	COG0596	Alpha beta hydrolase
GPY22_RS10840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY22_RS10845	COG1441	menaquinone biosynthetic process
GPY22_RS10865	COG0477	Major facilitator Superfamily
GPY22_RS10885	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GPY22_RS10890	COG1388	LysM domain
GPY22_RS10890	COG0741	lytic transglycosylase activity
GPY22_RS10910	COG1815	bacterial-type flagellum-dependent cell motility
GPY22_RS10915	COG1558	bacterial-type flagellum-dependent cell motility
GPY22_RS10920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY22_RS10925	COG1749	Flagellar hook protein flgE
GPY22_RS10935	COG4786	Flagellar basal body rod
GPY22_RS10940	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY22_RS10945	COG1706	bacterial-type flagellum-dependent cell motility
GPY22_RS10985	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GPY22_RS11035	COG0702	epimerase
GPY22_RS11040	COG3015	lipoprotein NlpE involved in copper resistance
GPY22_RS11050	COG1360	Flagellar Motor Protein
GPY22_RS11055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY22_RS11060	COG1191	sigma factor activity
GPY22_RS11065	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY22_RS11085	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY22_RS11090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY22_RS11105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY22_RS11115	COG1987	bacterial-type flagellum assembly
GPY22_RS11135	COG2885	chlorophyll binding
GPY22_RS11140	COG2204	response regulator
GPY22_RS11155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY22_RS11190	COG1946	Acyl-CoA thioesterase
GPY22_RS11195	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY22_RS11210	COG2203	Gaf domain
GPY22_RS11210	COG2199	diguanylate cyclase activity
GPY22_RS11250	COG0563	adenylate kinase activity
GPY22_RS11255	COG0431	NADPH-dependent FMN reductase
GPY22_RS11260	COG0697	spore germination
GPY22_RS11270	COG1278	Cold shock
GPY22_RS11295	COG2207	Transcriptional regulator
GPY22_RS11305	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY22_RS11305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY22_RS11310	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY22_RS11315	COG1881	PFAM PEBP family protein
GPY22_RS11320	COG2207	Transcriptional regulator
GPY22_RS11355	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY22_RS11370	COG0642	Histidine kinase
GPY22_RS11375	COG0745	RESPONSE REGULATOR receiver
GPY22_RS11380	COG0671	phosphoesterase, PA-phosphatase related
GPY22_RS11390	COG0513	Belongs to the DEAD box helicase family
GPY22_RS11395	COG1368	sulfuric ester hydrolase activity
GPY22_RS11400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY22_RS11425	COG4566	intracellular signal transduction
GPY22_RS11455	COG3258	Cytochrome c
GPY22_RS11480	COG1294	oxidase, subunit
GPY22_RS11520	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY22_RS11525	COG2814	Major facilitator Superfamily
GPY22_RS11540	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY22_RS11545	COG1169	isochorismate synthase
GPY22_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS11555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY22_RS11575	COG4592	Periplasmic binding protein
GPY22_RS11580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY22_RS11585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY22_RS11600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY22_RS11605	COG1120	ATPase activity
GPY22_RS11615	COG1609	Transcriptional regulator
GPY22_RS11620	COG2723	6-phospho-beta-galactosidase activity
GPY22_RS11640	COG0351	phosphomethylpyrimidine kinase
GPY22_RS11645	COG4172	Belongs to the ABC transporter superfamily
GPY22_RS11650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY22_RS11655	COG0601	transmembrane transport
GPY22_RS11670	COG1538	Outer membrane efflux protein
GPY22_RS11675	COG1566	PFAM secretion protein HlyD family protein
GPY22_RS11685	COG2207	Transcriptional regulator
GPY22_RS11685	COG3708	Transcriptional regulator
GPY22_RS11695	COG0745	RESPONSE REGULATOR receiver
GPY22_RS11705	COG1263	PTS System
GPY22_RS11705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY22_RS11720	COG2200	EAL domain
GPY22_RS11720	COG2199	diguanylate cyclase activity
GPY22_RS11720	COG2202	Pas domain
GPY22_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS11780	COG2986	histidine ammonia-lyase
GPY22_RS11785	COG1216	Glycosyl transferase, family 2
GPY22_RS11795	COG0318	PFAM AMP-dependent synthetase and ligase
GPY22_RS11805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY22_RS11810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY22_RS11815	COG0204	Acyl-transferase
GPY22_RS11815	COG0318	PFAM AMP-dependent synthetase and ligase
GPY22_RS11845	COG0601	transmembrane transport
GPY22_RS11850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY22_RS11855	COG0444	Belongs to the ABC transporter superfamily
GPY22_RS11870	COG0435	Glutathione S-transferase
GPY22_RS11875	COG3174	membrane
GPY22_RS11880	COG0280	phosphate acetyltransferase
GPY22_RS11880	COG0857	belongs to the CobB CobQ family
GPY22_RS11885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY22_RS11890	COG3092	negative regulation of chromosome organization
GPY22_RS11900	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY22_RS11925	COG0653	protein targeting
GPY22_RS11930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY22_RS11935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY22_RS11950	COG0243	molybdopterin cofactor binding
GPY22_RS11955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY22_RS11955	COG1648	precorrin-2 dehydrogenase activity
GPY22_RS11970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY22_RS11970	COG1116	anion transmembrane transporter activity
GPY22_RS11975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY22_RS11980	COG1116	anion transmembrane transporter activity
GPY22_RS11995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY22_RS12000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY22_RS12010	COG2226	methyltransferase
GPY22_RS12015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY22_RS12020	COG0501	Belongs to the peptidase M48B family
GPY22_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS12045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY22_RS12065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY22_RS12070	COG2915	High frequency lysogenization protein hflD homolog
GPY22_RS12075	COG0482	sulfurtransferase activity
GPY22_RS12080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY22_RS12085	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY22_RS12100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY22_RS12105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY22_RS12110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY22_RS12115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY22_RS12115	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY22_RS12120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY22_RS12125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY22_RS12135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY22_RS12135	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY22_RS12140	COG1187	pseudouridine synthase activity
GPY22_RS12150	COG1278	Cold shock
GPY22_RS12155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY22_RS12160	COG0542	response to heat
GPY22_RS12165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY22_RS12170	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY22_RS12175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY22_RS12185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY22_RS12200	COG0745	RESPONSE REGULATOR receiver
GPY22_RS12200	COG3706	GGDEF domain
GPY22_RS12205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY22_RS12230	COG3070	regulator of competence-specific genes
GPY22_RS12235	COG1609	Transcriptional regulator
GPY22_RS12240	COG3381	protein complex oligomerization
GPY22_RS12245	COG0745	RESPONSE REGULATOR receiver
GPY22_RS12250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY22_RS12255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY22_RS12260	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY22_RS12270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY22_RS12275	COG0189	ligase activity
GPY22_RS12285	COG4067	protein conserved in archaea
GPY22_RS12285	COG0189	ligase activity
GPY22_RS12290	COG0500	methyltransferase
GPY22_RS12295	COG4106	trans-aconitate 2-methyltransferase activity
GPY22_RS12310	COG1435	thymidine kinase activity
GPY22_RS12315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY22_RS12320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY22_RS12340	COG2116	formate transmembrane transporter activity
GPY22_RS12350	COG4459	periplasmic nitrate reductase
GPY22_RS12355	COG3005	denitrification pathway
GPY22_RS12360	COG0243	molybdopterin cofactor binding
GPY22_RS12395	COG4172	Belongs to the ABC transporter superfamily
GPY22_RS12405	COG4171	peptide transport system, permease
GPY22_RS12420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY22_RS12425	COG1842	Phage shock protein A
GPY22_RS12435	COG1983	PspC domain protein
GPY22_RS12440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY22_RS12455	COG0519	Catalyzes the synthesis of GMP from XMP
GPY22_RS12485	COG0626	cystathionine gamma-synthase activity
GPY22_RS12495	COG0733	neurotransmitter:sodium symporter activity
GPY22_RS12515	COG0564	pseudouridine synthase activity
GPY22_RS12525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY22_RS12530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY22_RS12535	COG4136	ATPase activity
GPY22_RS12545	COG4134	Bacterial extracellular solute-binding protein
GPY22_RS12555	COG3313	Fe-S protein
GPY22_RS12565	COG0842	Transport permease protein
GPY22_RS12570	COG1131	(ABC) transporter
GPY22_RS12595	COG3706	GGDEF domain
GPY22_RS12600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY22_RS12610	COG1278	Cold shock
GPY22_RS12645	COG3264	Mechanosensitive ion channel
GPY22_RS12645	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY22_RS12680	COG0531	amino acid
GPY22_RS12685	COG1982	Orn Lys Arg decarboxylase major
GPY22_RS12690	COG1982	Orn Lys Arg decarboxylase major
GPY22_RS12695	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY22_RS12710	COG0583	DNA-binding transcription factor activity
GPY22_RS12715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY22_RS12730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY22_RS12735	COG2205	protein histidine kinase activity
GPY22_RS12740	COG0745	RESPONSE REGULATOR receiver
GPY22_RS12760	COG2814	Major facilitator Superfamily
GPY22_RS12770	COG0702	epimerase
GPY22_RS12775	COG0534	Mate efflux family protein
GPY22_RS12780	COG4181	ATPase activity
GPY22_RS12795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY22_RS12835	COG0840	transmembrane signaling receptor activity
GPY22_RS12860	COG3265	gluconokinase activity
GPY22_RS12865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY22_RS12895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY22_RS12940	COG2989	Protein conserved in bacteria
GPY22_RS12945	COG3108	Peptidase M15
GPY22_RS12950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY22_RS12965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY22_RS12985	COG2197	response regulator
GPY22_RS12990	COG1846	Transcriptional regulator
GPY22_RS12995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY22_RS13005	COG2176	DNA-directed DNA polymerase activity
GPY22_RS13010	COG0517	IMP dehydrogenase activity
GPY22_RS13020	COG1448	Aminotransferase
GPY22_RS13040	COG0840	transmembrane signaling receptor activity
GPY22_RS13045	COG0720	synthase
GPY22_RS13050	COG1538	Outer membrane efflux protein
GPY22_RS13055	COG0577	efflux transmembrane transporter activity
GPY22_RS13055	COG1136	(ABC) transporter
GPY22_RS13065	COG1760	l-serine dehydratase
GPY22_RS13070	COG0814	amino acid
GPY22_RS13075	COG0494	nUDIX hydrolase
GPY22_RS13090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY22_RS13105	COG3106	COG3106 Predicted ATPase
GPY22_RS13115	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY22_RS13120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY22_RS13145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY22_RS13145	COG4191	Histidine kinase
GPY22_RS13155	COG0583	DNA-binding transcription factor activity
GPY22_RS13160	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY22_RS13165	COG0778	Nitroreductase
GPY22_RS13170	COG2991	Protein conserved in bacteria
GPY22_RS13180	COG3250	beta-galactosidase activity
GPY22_RS13190	COG1129	ABC transporter
GPY22_RS13230	COG2169	Transcriptional regulator
GPY22_RS13230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY22_RS13245	COG0372	Belongs to the citrate synthase family
GPY22_RS13250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPY22_RS13255	COG2828	Protein conserved in bacteria
GPY22_RS13270	COG1566	PFAM secretion protein HlyD family protein
GPY22_RS13275	COG2814	Major facilitator Superfamily
GPY22_RS13290	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY22_RS13295	COG2200	EAL domain
GPY22_RS13305	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY22_RS13315	COG0625	glutathione transferase activity
GPY22_RS13335	COG2731	YhcH YjgK YiaL family protein
GPY22_RS13340	COG0584	glycerophosphoryl diester phosphodiesterase
GPY22_RS13345	COG1349	DNA-binding transcription factor activity
GPY22_RS13350	COG3842	ATPase activity
GPY22_RS13355	COG0395	ABC-type sugar transport system, permease component
GPY22_RS13380	COG3040	lipid binding
GPY22_RS13395	COG0811	peptide transport
GPY22_RS13400	COG0848	biopolymer transport protein
GPY22_RS13420	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY22_RS13425	COG1793	dna ligase
GPY22_RS13440	COG0307	riboflavin synthase, alpha
GPY22_RS13460	COG0791	NLP P60 protein
GPY22_RS13465	COG0840	transmembrane signaling receptor activity
GPY22_RS13480	COG1940	carbohydrate kinase activity
GPY22_RS13490	COG0303	'Molybdopterin
GPY22_RS13495	COG0746	molybdenum cofactor guanylyltransferase activity
GPY22_RS13500	COG3842	ATPase activity
GPY22_RS13505	COG4662	Binding-protein-dependent transport system inner membrane component
GPY22_RS13515	COG2204	response regulator
GPY22_RS13535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY22_RS13555	COG3381	protein complex oligomerization
GPY22_RS13570	COG0437	4 iron, 4 sulfur cluster binding
GPY22_RS13585	COG0004	ammonium transporteR
GPY22_RS13590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY22_RS13600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY22_RS13605	COG1177	transmembrane transport
GPY22_RS13610	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY22_RS13615	COG3842	ATPase activity
GPY22_RS13640	COG0589	response to stress
GPY22_RS13645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY22_RS13660	COG2217	Heavy metal translocating P-type atpase
GPY22_RS13670	COG2010	Cytochrome c
GPY22_RS13685	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY22_RS13720	COG3120	sequence-specific DNA binding
GPY22_RS13730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY22_RS13755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY22_RS13755	COG0116	Belongs to the methyltransferase superfamily
GPY22_RS13765	COG0167	dihydroorotate dehydrogenase activity
GPY22_RS13805	COG1956	GAF domain-containing protein
GPY22_RS13810	COG1132	(ABC) transporter
GPY22_RS13815	COG2995	paraquat-inducible protein a
GPY22_RS13820	COG3008	intermembrane lipid transfer
GPY22_RS13825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY22_RS13825	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY22_RS13830	COG2996	Protein conserved in bacteria
GPY22_RS13850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY22_RS13875	COG1115	amino acid carrier protein
GPY22_RS13900	COG3501	Rhs element vgr protein
GPY22_RS13920	COG1643	Atp-dependent helicase
GPY22_RS13935	COG3005	denitrification pathway
GPY22_RS13990	COG3706	GGDEF domain
GPY22_RS14005	COG2999	glutathione oxidoreductase activity
GPY22_RS14025	COG0745	RESPONSE REGULATOR receiver
GPY22_RS14025	COG3706	GGDEF domain
GPY22_RS14035	COG0243	molybdopterin cofactor binding
GPY22_RS14055	COG0602	queuosine metabolic process
GPY22_RS14060	COG0561	phosphatase activity
GPY22_RS14075	COG4597	amino acid ABC transporter
GPY22_RS14080	COG0765	amino acid transport
GPY22_RS14085	COG1126	abc transporter atp-binding protein
GPY22_RS14090	COG0670	Belongs to the BI1 family
GPY22_RS14095	COG2920	part of a sulfur-relay system
GPY22_RS14100	COG1254	Belongs to the acylphosphatase family
GPY22_RS14105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY22_RS14110	COG3391	amine dehydrogenase activity
GPY22_RS14150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY22_RS14160	COG0745	RESPONSE REGULATOR receiver
GPY22_RS14210	COG1278	Cold shock
GPY22_RS14250	COG1715	Restriction endonuclease
GPY22_RS14380	COG0494	nUDIX hydrolase
GPY22_RS14460	COG4386	tail sheath protein
GPY22_RS14500	COG3706	GGDEF domain
GPY22_RS14500	COG0745	RESPONSE REGULATOR receiver
GPY22_RS14515	COG0835	chemotaxis
GPY22_RS14515	COG0784	Response regulator, receiver
GPY22_RS14525	COG4565	transcriptional regulatory protein
GPY22_RS14545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY22_RS14565	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY22_RS14570	COG3063	Type IV pilus biogenesis stability protein PilW
GPY22_RS14595	COG0583	DNA-binding transcription factor activity
GPY22_RS14645	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY22_RS14650	COG4139	cobalamin transport
GPY22_RS14655	COG2988	succinylglutamate desuccinylase activity
GPY22_RS14670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY22_RS14680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPY22_RS14700	COG2925	Exonuclease
GPY22_RS14715	COG0295	cytidine deaminase activity
GPY22_RS14750	COG0500	methyltransferase
GPY22_RS14760	COG0776	regulation of translation
GPY22_RS14765	COG0072	phenylalanine-tRNA ligase activity
GPY22_RS14765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY22_RS14790	COG2133	pyrroloquinoline quinone binding
GPY22_RS14825	COG2197	response regulator
GPY22_RS14845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY22_RS14870	COG0010	Belongs to the arginase family
GPY22_RS14880	COG2986	histidine ammonia-lyase
GPY22_RS14900	COG0277	FAD linked oxidase domain protein
GPY22_RS14900	COG0247	lactate metabolic process
GPY22_RS14915	COG2885	chlorophyll binding
GPY22_RS14940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY22_RS14945	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS14950	COG2957	Belongs to the agmatine deiminase family
GPY22_RS14960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY22_RS14965	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS14975	COG1278	Cold shock
GPY22_RS14980	COG3036	rescue of stalled ribosome
GPY22_RS15010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY22_RS15010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY22_RS15015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY22_RS15105	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY22_RS15135	COG0798	PFAM Bile acid sodium symporter
GPY22_RS15175	COG4964	Belongs to the GSP D family
GPY22_RS15240	COG0840	transmembrane signaling receptor activity
GPY22_RS15255	COG4533	DNA binding
GPY22_RS15260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY22_RS15265	COG3835	regulator
GPY22_RS15270	COG2610	gluconate transmembrane transporter activity
GPY22_RS15275	COG1929	Belongs to the glycerate kinase type-1 family
GPY22_RS15280	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY22_RS15285	COG1473	amidohydrolase
GPY22_RS15300	COG0531	amino acid
GPY22_RS15320	COG0583	DNA-binding transcription factor activity
GPY22_RS15335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY22_RS15340	COG0363	glucosamine-6-phosphate deaminase activity
GPY22_RS15345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY22_RS15360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY22_RS15380	COG0346	lactoylglutathione lyase activity
GPY22_RS15395	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS15400	COG0156	8-amino-7-oxononanoate synthase activity
GPY22_RS15405	COG1063	alcohol dehydrogenase
GPY22_RS15460	COG2084	Dehydrogenase
GPY22_RS15465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY22_RS15475	COG0242	peptide deformylase activity
GPY22_RS15500	COG2246	polysaccharide biosynthetic process
GPY22_RS15505	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY22_RS15515	COG1132	(ABC) transporter
GPY22_RS15520	COG1132	(ABC) transporter
GPY22_RS15530	COG2267	carboxylic ester hydrolase activity
GPY22_RS15535	COG0583	DNA-binding transcription factor activity
GPY22_RS15545	COG0251	oxidation-reduction process
GPY22_RS15555	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY22_RS15560	COG3047	cAMP biosynthetic process
GPY22_RS15565	COG3227	Zinc metalloprotease (Elastase)
GPY22_RS15585	COG4989	oxidoreductase activity
GPY22_RS15590	COG3275	phosphorelay sensor kinase activity
GPY22_RS15595	COG3279	Response regulator of the LytR AlgR family
GPY22_RS15600	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY22_RS15650	COG1522	sequence-specific DNA binding
GPY22_RS15660	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY22_RS15665	COG5380	lipid catabolic process
GPY22_RS15670	COG3291	Pkd domain containing protein
GPY22_RS15670	COG4412	M6 family metalloprotease domain protein
GPY22_RS15690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY22_RS15700	COG4604	ABC transporter, ATP-binding protein
GPY22_RS15705	COG2207	Transcriptional regulator
GPY22_RS15705	COG1609	Transcriptional regulator
GPY22_RS15720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY22_RS15760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY22_RS15765	COG1454	alcohol dehydrogenase
GPY22_RS15770	COG1609	Transcriptional regulator
GPY22_RS15770	COG2207	Transcriptional regulator
GPY22_RS15800	COG3634	alkyl hydroperoxide reductase activity
GPY22_RS15805	COG0450	alkyl hydroperoxide reductase
GPY22_RS15820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY22_RS15825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY22_RS15830	COG1960	acyl-CoA dehydrogenase activity
GPY22_RS15840	COG0183	Belongs to the thiolase family
GPY22_RS15855	COG1024	Enoyl-CoA hydratase
GPY22_RS15860	COG1024	Enoyl-CoA hydratase
GPY22_RS15870	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS15885	COG0653	protein targeting
GPY22_RS15900	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY22_RS15920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY22_RS15920	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY22_RS15925	COG1464	Belongs to the NlpA lipoprotein family
GPY22_RS15945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY22_RS15950	COG0573	inorganic phosphate transmembrane transporter activity
GPY22_RS15960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY22_RS15980	COG0625	glutathione transferase activity
GPY22_RS16005	COG0438	transferase activity, transferring glycosyl groups
GPY22_RS16010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY22_RS16020	COG0438	transferase activity, transferring glycosyl groups
GPY22_RS16060	COG2204	response regulator
GPY22_RS16130	COG2721	sulfolactate sulfo-lyase activity
GPY22_RS16155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY22_RS16160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY22_RS16165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY22_RS16200	COG1280	lysine exporter protein (LysE YggA)
GPY22_RS16205	COG0400	carboxylic ester hydrolase activity
GPY22_RS16215	COG0583	DNA-binding transcription factor activity
GPY22_RS16230	COG2423	ornithine cyclodeaminase activity
GPY22_RS16245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY22_RS16265	COG0583	DNA-binding transcription factor activity
GPY22_RS16275	COG0633	Ferredoxin
GPY22_RS16275	COG3217	Mosc domain protein beta barrel domain protein
GPY22_RS16325	COG0784	Response regulator, receiver
GPY22_RS16325	COG2198	Histidine kinase
GPY22_RS16325	COG2205	protein histidine kinase activity
GPY22_RS16330	COG3437	response regulator, receiver
GPY22_RS16345	COG0747	negative chemotaxis
GPY22_RS16365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY22_RS16380	COG3706	GGDEF domain
GPY22_RS16385	COG0110	maltose O-acetyltransferase activity
GPY22_RS16390	COG1349	DNA-binding transcription factor activity
GPY22_RS16410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY22_RS16420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY22_RS16420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY22_RS16420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY22_RS16425	COG2207	Transcriptional regulator
GPY22_RS16435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY22_RS16450	COG1252	NADH dehydrogenase
GPY22_RS16460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY22_RS16465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY22_RS16475	COG3710	Transcriptional regulator
GPY22_RS16540	COG0582	viral genome integration into host DNA
GPY22_RS16555	COG0583	DNA-binding transcription factor activity
GPY22_RS16575	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY22_RS16580	COG0513	Belongs to the DEAD box helicase family
GPY22_RS16585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY22_RS16625	COG4628	conserved protein (DUF2132)
GPY22_RS16635	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS16690	COG0789	Transcriptional regulator
GPY22_RS16695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY22_RS16755	COG0454	-acetyltransferase
GPY22_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS16785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY22_RS16815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY22_RS16825	COG0494	nUDIX hydrolase
GPY22_RS16840	COG0456	acetyltransferase
GPY22_RS16850	COG1335	isochorismatase
GPY22_RS16880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY22_RS16885	COG1309	transcriptional regulator
GPY22_RS16900	COG0583	DNA-binding transcription factor activity
GPY22_RS16910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY22_RS16920	COG0745	RESPONSE REGULATOR receiver
GPY22_RS16925	COG1280	lysine exporter protein (LysE YggA)
GPY22_RS16980	COG1328	CTP reductase activity
GPY22_RS16985	COG0602	queuosine metabolic process
GPY22_RS16995	COG4067	protein conserved in archaea
GPY22_RS16995	COG0189	ligase activity
GPY22_RS17000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY22_RS17000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY22_RS17000	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY22_RS17005	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY22_RS17015	COG1609	Transcriptional regulator
GPY22_RS17025	COG0419	ATPase involved in DNA repair
GPY22_RS17030	COG0784	Response regulator, receiver
GPY22_RS17030	COG2205	protein histidine kinase activity
GPY22_RS17035	COG0156	8-amino-7-oxononanoate synthase activity
GPY22_RS17045	COG0038	chloride channel
GPY22_RS17050	COG0523	cobalamin synthesis protein
GPY22_RS17060	COG2207	Transcriptional regulator
GPY22_RS17070	COG3437	response regulator, receiver
GPY22_RS17090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY22_RS17130	COG3038	cytochrome b561
GPY22_RS17135	COG2353	YceI-like domain
GPY22_RS17140	COG2116	formate transmembrane transporter activity
GPY22_RS17155	COG3593	DNA synthesis involved in DNA repair
GPY22_RS17160	COG0737	Belongs to the 5'-nucleotidase family
GPY22_RS17180	COG0501	Belongs to the peptidase M48B family
GPY22_RS17185	COG2050	protein possibly involved in aromatic compounds catabolism
GPY22_RS17205	COG1629	transport
GPY22_RS17205	COG4771	TonB-dependent receptor
GPY22_RS17210	COG0583	DNA-binding transcription factor activity
GPY22_RS17215	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY22_RS17215	COG1042	CoA-binding domain protein
GPY22_RS17215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY22_RS17225	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY22_RS17240	COG0023	Translation Initiation Factor
GPY22_RS17260	COG0745	RESPONSE REGULATOR receiver
GPY22_RS17275	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY22_RS17300	COG3706	GGDEF domain
GPY22_RS17310	COG1309	transcriptional regulator
GPY22_RS17315	COG1129	ABC transporter
GPY22_RS17355	COG2351	hydroxyisourate hydrolase activity
GPY22_RS17380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY22_RS17410	COG0765	amino acid transport
GPY22_RS17445	COG2233	PERMEase
GPY22_RS17460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY22_RS17490	COG3710	Transcriptional regulator
GPY22_RS17530	COG0488	(ABC) transporter
GPY22_RS17540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GPY22_RS17560	COG2207	Transcriptional regulator
GPY22_RS17565	COG1979	alcohol dehydrogenase
GPY22_RS17630	COG2501	S4 domain
GPY22_RS17645	COG3706	GGDEF domain
GPY22_RS17670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY22_RS17675	COG4172	Belongs to the ABC transporter superfamily
GPY22_RS17680	COG4239	(ABC) transporter, permease
GPY22_RS17685	COG4174	ABC transporter (Permease)
GPY22_RS17690	COG4166	transmembrane transport
GPY22_RS17745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY22_RS17755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY22_RS17765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY22_RS17770	COG1011	Hydrolase
GPY22_RS17780	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY22_RS17785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY22_RS17800	COG4303	Ethanolamine ammonia lyase large subunit
GPY22_RS17810	COG0531	amino acid
GPY22_RS17815	COG0302	gtp cyclohydrolase
GPY22_RS17830	COG2897	thiosulfate sulfurtransferase activity
GPY22_RS17845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY22_RS17850	COG0840	transmembrane signaling receptor activity
GPY22_RS17865	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY22_RS17870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY22_RS17875	COG0840	transmembrane signaling receptor activity
GPY22_RS17880	COG2814	Major facilitator Superfamily
GPY22_RS17895	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY22_RS17900	COG2197	response regulator
GPY22_RS17920	COG0243	molybdopterin cofactor binding
GPY22_RS17960	COG0183	Belongs to the thiolase family
GPY22_RS17970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY22_RS17975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY22_RS17995	COG3706	GGDEF domain
GPY22_RS18015	COG2207	Transcriptional regulator
GPY22_RS18020	COG1979	alcohol dehydrogenase
GPY22_RS18050	COG0469	pyruvate kinase activity
GPY22_RS18055	COG2198	Histidine kinase
GPY22_RS18055	COG2205	protein histidine kinase activity
GPY22_RS18055	COG0784	Response regulator, receiver
GPY22_RS18060	COG1879	ABC-type sugar transport system periplasmic component
GPY22_RS18065	COG1803	Methylglyoxal synthase
GPY22_RS18070	COG1335	isochorismatase
GPY22_RS18125	COG1289	transmembrane transporter activity
GPY22_RS18140	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY22_RS18145	COG4149	molybdate abc transporter
GPY22_RS18150	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY22_RS18155	COG1492	cobalamin metabolic process
GPY22_RS18175	COG5002	protein histidine kinase activity
GPY22_RS18175	COG0784	Response regulator, receiver
GPY22_RS18180	COG1879	ABC-type sugar transport system periplasmic component
GPY22_RS18190	COG2827	Endonuclease containing a URI domain
GPY22_RS18235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY22_RS18240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY22_RS18245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY22_RS18250	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY22_RS18270	COG0297	glycogen (starch) synthase activity
GPY22_RS18270	COG0438	transferase activity, transferring glycosyl groups
GPY22_RS18275	COG0438	transferase activity, transferring glycosyl groups
GPY22_RS18300	COG1596	polysaccharide export
GPY22_RS18310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY22_RS18325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY22_RS18330	COG3118	belongs to the thioredoxin family
GPY22_RS18370	COG2146	nitrite reductase [NAD(P)H] activity
GPY22_RS18405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY22_RS18460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY22_RS18475	COG2186	Transcriptional regulator
GPY22_RS18500	COG0246	Mannitol dehydrogenase
GPY22_RS18505	COG1904	glucuronate isomerase
GPY22_RS18510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY22_RS18515	COG0800	Aldolase
GPY22_RS18520	COG1294	oxidase, subunit
GPY22_RS18525	COG1271	oxidase subunit
GPY22_RS18535	COG3781	membrane
GPY22_RS18540	COG0583	DNA-binding transcription factor activity
GPY22_RS18570	COG0330	HflC and HflK could
GPY22_RS18605	COG0583	DNA-binding transcription factor activity
GPY22_RS18615	COG0463	Glycosyl transferase, family 2
GPY22_RS18625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY22_RS18665	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY22_RS18680	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY22_RS18690	COG1309	transcriptional regulator
GPY22_RS18695	COG0513	Belongs to the DEAD box helicase family
GPY22_RS18700	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY22_RS18705	COG0814	amino acid
GPY22_RS18710	COG0840	transmembrane signaling receptor activity
GPY22_RS18715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY22_RS18725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY22_RS18735	COG1984	allophanate hydrolase subunit 2
GPY22_RS18745	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY22_RS18750	COG4181	ATPase activity
GPY22_RS18760	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY22_RS18765	COG5001	Diguanylate cyclase
GPY22_RS18765	COG1716	ATPase activity
GPY22_RS18775	COG0484	heat shock protein binding
GPY22_RS18795	COG0546	phosphoglycolate phosphatase activity
GPY22_RS18815	COG5001	Diguanylate cyclase
GPY22_RS18820	COG3706	GGDEF domain
GPY22_RS18845	COG0509	glycine decarboxylation via glycine cleavage system
GPY22_RS18870	COG3122	Protein conserved in bacteria
GPY22_RS18915	COG1280	lysine exporter protein (LysE YggA)
GPY22_RS18935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY22_RS18980	COG1280	lysine exporter protein (LysE YggA)
GPY22_RS18985	COG2070	2-Nitropropane dioxygenase
GPY22_RS18990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY22_RS19000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY22_RS19035	COG3338	carbonate dehydratase activity
GPY22_RS19070	COG0765	amino acid transport
GPY22_RS19085	COG1522	sequence-specific DNA binding
GPY22_RS19095	COG1166	arginine decarboxylase activity
GPY22_RS19115	COG2113	Glycine betaine
GPY22_RS19140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY22_RS19155	COG0113	porphobilinogen synthase activity
GPY22_RS19175	COG0583	DNA-binding transcription factor activity
GPY22_RS19185	COG0561	phosphatase activity
GPY22_RS19190	COG0527	aspartate kinase activity
GPY22_RS19195	COG0662	Cupin 2, conserved barrel domain protein
GPY22_RS19200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY22_RS19205	COG0456	acetyltransferase
GPY22_RS19215	COG0861	Integral membrane protein TerC family
GPY22_RS19225	COG0534	Mate efflux family protein
GPY22_RS19230	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY22_RS19235	COG3186	Phenylalanine-4-hydroxylase
GPY22_RS19240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY22_RS19250	COG0642	Histidine kinase
GPY22_RS19255	COG0745	RESPONSE REGULATOR receiver
GPY22_RS19275	COG1022	Amp-dependent synthetase and ligase
GPY22_RS19285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY22_RS19310	COG2171	N-acyltransferase activity
GPY22_RS19320	COG1765	OsmC-like protein
GPY22_RS19335	COG5001	Diguanylate cyclase
GPY22_RS19335	COG3300	MHYT domain
GPY22_RS19340	COG5002	protein histidine kinase activity
GPY22_RS19340	COG2205	protein histidine kinase activity
GPY22_RS19340	COG0784	Response regulator, receiver
GPY22_RS19365	COG2200	EAL domain
GPY22_RS19370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY22_RS19400	COG1522	sequence-specific DNA binding
GPY22_RS19405	COG0531	amino acid
GPY22_RS19415	COG0748	coenzyme F420 binding
GPY22_RS19420	COG3721	Heme iron utilization protein
GPY22_RS19425	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY22_RS19430	COG0811	peptide transport
GPY22_RS19435	COG0848	biopolymer transport protein
GPY22_RS19445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY22_RS19450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY22_RS19480	COG0633	Ferredoxin
GPY22_RS19480	COG3217	Mosc domain protein beta barrel domain protein
GPY22_RS19485	COG0418	dihydroorotase activity
GPY22_RS19490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY22_RS19495	COG2354	Protein conserved in bacteria
GPY22_RS19555	COG3842	ATPase activity
GPY22_RS19595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY22_RS19605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY22_RS19625	COG0517	IMP dehydrogenase activity
GPY22_RS19630	COG1414	Transcriptional regulator
GPY22_RS19635	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS19645	COG1917	Cupin 2, conserved barrel domain protein
GPY22_RS19660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY22_RS19665	COG0800	Aldolase
GPY22_RS19685	COG1175	transmembrane transport
GPY22_RS19690	COG0395	ABC-type sugar transport system, permease component
GPY22_RS19695	COG3842	ATPase activity
GPY22_RS19700	COG1653	transport
GPY22_RS19710	COG0534	Mate efflux family protein
GPY22_RS19720	COG0823	Involved in the tonB-independent uptake of proteins
GPY22_RS19725	COG0393	Putative heavy-metal-binding
GPY22_RS19735	COG1522	sequence-specific DNA binding
GPY22_RS19755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY22_RS19785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY22_RS19790	COG0835	chemotaxis
GPY22_RS19790	COG0784	Response regulator, receiver
GPY22_RS19795	COG2315	Protein conserved in bacteria
GPY22_RS19800	COG1846	Transcriptional regulator
GPY22_RS19810	COG3706	GGDEF domain
GPY22_RS19830	COG3706	GGDEF domain
GPY22_RS19855	COG5001	Diguanylate cyclase
GPY22_RS19865	COG1741	Belongs to the pirin family
GPY22_RS19870	COG0745	RESPONSE REGULATOR receiver
GPY22_RS19975	COG3501	Rhs element vgr protein
GPY22_RS19985	COG2814	Major facilitator Superfamily
GPY22_RS20005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY22_RS20010	COG0569	domain protein
GPY22_RS20015	COG0668	transmembrane transport
GPY22_RS20020	COG2211	Major facilitator Superfamily
GPY22_RS20030	COG1067	ATP-dependent peptidase activity
GPY22_RS20040	COG4172	Belongs to the ABC transporter superfamily
GPY22_RS20045	COG0583	DNA-binding transcription factor activity
GPY22_RS20055	COG1304	FMN binding
GPY22_RS20080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY22_RS20090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY22_RS20100	COG3152	Membrane
GPY22_RS20120	COG0583	DNA-binding transcription factor activity
GPY22_RS20135	COG1942	4-Oxalocrotonate Tautomerase
GPY22_RS20145	COG0625	glutathione transferase activity
GPY22_RS20150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY22_RS20160	COG0697	spore germination
GPY22_RS20185	COG2169	Transcriptional regulator
GPY22_RS20205	COG3447	MASE1 domain protein
GPY22_RS20205	COG5002	protein histidine kinase activity
GPY22_RS20205	COG5001	Diguanylate cyclase
GPY22_RS20215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY22_RS20230	COG0109	protoheme IX farnesyltransferase activity
GPY22_RS20265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY22_RS20275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY22_RS20280	COG1902	pentaerythritol trinitrate reductase activity
GPY22_RS20290	COG1280	lysine exporter protein (LysE YggA)
GPY22_RS20315	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY22_RS20320	COG1846	Transcriptional regulator
GPY22_RS20325	COG1764	response to oxidative stress
GPY22_RS20360	COG1917	Cupin 2, conserved barrel domain protein
GPY22_RS20360	COG2169	Transcriptional regulator
GPY22_RS20380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPY22_RS20390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY22_RS20395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY22_RS20400	COG2259	Doxx family
GPY22_RS20405	COG0402	S-adenosylhomocysteine deaminase activity
GPY22_RS20430	COG0363	glucosamine-6-phosphate deaminase activity
GPY22_RS20445	COG0739	heme binding
GPY22_RS20450	COG2213	PTS system mannitol-specific
GPY22_RS20450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY22_RS20460	COG3722	fumarate hydratase activity
GPY22_RS20475	COG1473	amidohydrolase
GPY22_RS20480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY22_RS20495	COG0095	Lipoate-protein ligase
GPY22_RS20500	COG0443	Heat shock 70 kDa protein
GPY22_RS20520	COG2176	DNA-directed DNA polymerase activity
GPY22_RS20545	COG2205	protein histidine kinase activity
GPY22_RS20555	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY22_RS20565	COG1403	HNH endonuclease
GPY22_RS20590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY22_RS20600	COG3304	Inner membrane component domain
GPY22_RS20605	COG2329	Antibiotic biosynthesis monooxygenase
GPY22_RS20620	COG2207	Transcriptional regulator
GPY22_RS20620	COG1609	Transcriptional regulator
GPY22_RS20640	COG2910	NAD(P)H-binding
GPY22_RS20645	COG0583	DNA-binding transcription factor activity
GPY22_RS20660	COG1349	DNA-binding transcription factor activity
GPY22_RS20665	COG2084	Dehydrogenase
GPY22_RS20670	COG3395	kinase activity
GPY22_RS20680	COG3622	Belongs to the hyi family
GPY22_RS20685	COG2610	gluconate transmembrane transporter activity
GPY22_RS20690	COG1522	sequence-specific DNA binding
GPY22_RS20700	COG0724	RNA recognition motif
GPY22_RS20715	COG2226	methyltransferase
GPY22_RS20720	COG0583	DNA-binding transcription factor activity
GPY22_RS20730	COG0513	Belongs to the DEAD box helicase family
GPY22_RS20735	COG0859	PFAM glycosyl transferase family 9
GPY22_RS20785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPY22_RS20795	COG0259	pyridoxamine-phosphate oxidase activity
GPY22_RS20825	COG0745	RESPONSE REGULATOR receiver
GPY22_RS20840	COG2201	protein-glutamate methylesterase activity
GPY22_RS20850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY22_RS20860	COG0835	chemotaxis
GPY22_RS20865	COG0835	chemotaxis
GPY22_RS20870	COG0643	Histidine kinase
GPY22_RS20870	COG2198	Histidine kinase
GPY22_RS20875	COG0745	RESPONSE REGULATOR receiver
GPY22_RS20890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY22_RS20925	COG0217	transcriptional regulatory protein
GPY22_RS20955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY22_RS20960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY22_RS20965	COG1845	cytochrome c oxidase, subunit III
GPY22_RS20970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY22_RS20985	COG2909	trisaccharide binding
GPY22_RS20990	COG0058	SHG alpha-glucan phosphorylase activity
GPY22_RS20995	COG1640	4-alpha-glucanotransferase
GPY22_RS21000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY22_RS21010	COG3501	Rhs element vgr protein
GPY22_RS21030	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GPY22_RS21055	COG0471	metal ion transport
GPY22_RS21070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY22_RS21085	COG2188	Transcriptional regulator
GPY22_RS21125	COG0671	phosphoesterase, PA-phosphatase related
GPY22_RS21135	COG1132	(ABC) transporter
GPY22_RS21165	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY22_RS21170	COG1162	GTPase activity
GPY22_RS21180	COG1999	signal sequence binding
GPY22_RS21195	COG0786	glutamate:sodium symporter activity
GPY22_RS21230	COG1566	PFAM secretion protein HlyD family protein
GPY22_RS21240	COG3706	GGDEF domain
GPY22_RS21255	COG0813	purine-nucleoside phosphorylase activity
GPY22_RS21260	COG3272	Protein of unknown function (DUF1722)
GPY22_RS21270	COG0415	Belongs to the DNA photolyase family
GPY22_RS21285	COG0513	Belongs to the DEAD box helicase family
GPY22_RS21290	COG0840	transmembrane signaling receptor activity
GPY22_RS21295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY22_RS21300	COG0573	inorganic phosphate transmembrane transporter activity
GPY22_RS21305	COG0581	inorganic phosphate transmembrane transporter activity
GPY22_RS21315	COG2199	diguanylate cyclase activity
GPY22_RS21330	COG0659	secondary active sulfate transmembrane transporter activity
GPY22_RS21350	COG3300	MHYT domain
GPY22_RS21350	COG5001	Diguanylate cyclase
GPY22_RS21360	COG2814	Major facilitator Superfamily
GPY22_RS21375	COG0697	spore germination
GPY22_RS21380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY22_RS21395	COG0778	Nitroreductase
GPY22_RS21400	COG1342	Belongs to the UPF0251 family
GPY22_RS21410	COG0583	DNA-binding transcription factor activity
GPY22_RS21415	COG3384	dioxygenase
GPY22_RS21425	COG0840	transmembrane signaling receptor activity
GPY22_RS21455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY22_RS21460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY22_RS21465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY22_RS21480	COG0583	DNA-binding transcription factor activity
GPY22_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
GPY22_RS21510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY22_RS21515	COG1349	DNA-binding transcription factor activity
GPY22_RS21525	COG4702	Belongs to the UPF0303 family
GPY22_RS21535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY22_RS21550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY22_RS21570	COG2814	Major facilitator Superfamily
GPY22_RS21580	COG1902	pentaerythritol trinitrate reductase activity
GPY22_RS21585	COG0656	L-ascorbic acid biosynthetic process
GPY22_RS21590	COG2200	EAL domain
GPY22_RS21600	COG3842	ATPase activity
GPY22_RS21630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY22_RS21645	COG2130	NADP-dependent
GPY22_RS21650	COG1309	transcriptional regulator
GPY22_RS21670	COG1846	Transcriptional regulator
GPY22_RS21790	COG1869	D-ribose catabolic process
GPY22_RS21800	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY22_RS21805	COG1879	ABC-type sugar transport system periplasmic component
GPY22_RS21810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY22_RS21820	COG0583	DNA-binding transcription factor activity
GPY22_RS21830	COG0584	glycerophosphoryl diester phosphodiesterase
GPY22_RS21835	COG2271	Major facilitator Superfamily
GPY22_RS21840	COG3300	MHYT domain
GPY22_RS21840	COG5001	Diguanylate cyclase
GPY22_RS21865	COG2188	Transcriptional regulator
GPY22_RS21880	COG1929	Belongs to the glycerate kinase type-1 family
GPY22_RS21890	COG2204	response regulator
GPY22_RS21905	COG0579	oxidoreductase
GPY22_RS21915	COG3530	Putative quorum-sensing-regulated virulence factor
GPY22_RS21925	COG0589	response to stress
GPY22_RS21930	COG3171	Protein conserved in bacteria
GPY22_RS21955	COG0583	DNA-binding transcription factor activity
GPY22_RS22005	COG1012	belongs to the aldehyde dehydrogenase family
GPY22_RS22010	COG3724	N-succinylarginine dihydrolase activity
GPY22_RS22020	COG0745	RESPONSE REGULATOR receiver
GPY22_RS22020	COG3706	GGDEF domain
GPY22_RS22035	COG3706	GGDEF domain
GPY22_RS22050	COG2304	oxidoreductase activity
GPY22_RS22070	COG0714	Associated with various cellular activities
GPY22_RS22090	COG0366	Alpha amylase catalytic
GPY22_RS22100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY22_RS22115	COG3604	Transcriptional regulator