locus-tag	class	description
GPY08_RS00115	COG0210	DNA helicase
GPY08_RS00120	COG1335	isochorismatase
GPY08_RS00125	COG1803	Methylglyoxal synthase
GPY08_RS00130	COG1879	ABC-type sugar transport system periplasmic component
GPY08_RS00135	COG2205	protein histidine kinase activity
GPY08_RS00135	COG0784	Response regulator, receiver
GPY08_RS00135	COG2198	Histidine kinase
GPY08_RS00140	COG0469	pyruvate kinase activity
GPY08_RS00150	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY08_RS00170	COG1979	alcohol dehydrogenase
GPY08_RS00175	COG2207	Transcriptional regulator
GPY08_RS00195	COG3706	GGDEF domain
GPY08_RS00215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY08_RS00220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY08_RS00230	COG0183	Belongs to the thiolase family
GPY08_RS00270	COG0243	molybdopterin cofactor binding
GPY08_RS00285	COG3850	Histidine kinase
GPY08_RS00290	COG2197	response regulator
GPY08_RS00295	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY08_RS00310	COG2814	Major facilitator Superfamily
GPY08_RS00315	COG0840	transmembrane signaling receptor activity
GPY08_RS00320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY08_RS00325	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY08_RS00340	COG0840	transmembrane signaling receptor activity
GPY08_RS00345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY08_RS00360	COG2897	thiosulfate sulfurtransferase activity
GPY08_RS00365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY08_RS00390	COG4303	Ethanolamine ammonia lyase large subunit
GPY08_RS00405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY08_RS00405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY08_RS00415	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY08_RS00425	COG1011	Hydrolase
GPY08_RS00430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY08_RS00450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY08_RS00460	COG3842	ATPase activity
GPY08_RS00480	COG2866	Carboxypeptidase
GPY08_RS00505	COG4166	transmembrane transport
GPY08_RS00510	COG4174	ABC transporter (Permease)
GPY08_RS00520	COG4172	Belongs to the ABC transporter superfamily
GPY08_RS00525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPY08_RS00545	COG2203	Gaf domain
GPY08_RS00545	COG3706	GGDEF domain
GPY08_RS00545	COG4251	negative regulation of phosphorylation
GPY08_RS00545	COG5001	Diguanylate cyclase
GPY08_RS00555	COG3706	GGDEF domain
GPY08_RS00565	COG2501	S4 domain
GPY08_RS00635	COG1979	alcohol dehydrogenase
GPY08_RS00640	COG2207	Transcriptional regulator
GPY08_RS00690	COG2814	Major facilitator Superfamily
GPY08_RS00710	COG3710	Transcriptional regulator
GPY08_RS00740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY08_RS00755	COG2233	PERMEase
GPY08_RS00775	COG1953	Uracil, thiamine, allantoin
GPY08_RS00785	COG0765	amino acid transport
GPY08_RS00790	COG0765	amino acid transport
GPY08_RS00820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY08_RS00840	COG0402	S-adenosylhomocysteine deaminase activity
GPY08_RS00845	COG2351	hydroxyisourate hydrolase activity
GPY08_RS00890	COG1309	transcriptional regulator
GPY08_RS00900	COG3706	GGDEF domain
GPY08_RS00910	COG0745	RESPONSE REGULATOR receiver
GPY08_RS00910	COG3706	GGDEF domain
GPY08_RS00925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY08_RS00930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY08_RS00940	COG0745	RESPONSE REGULATOR receiver
GPY08_RS01015	COG0023	Translation Initiation Factor
GPY08_RS01040	COG1042	CoA-binding domain protein
GPY08_RS01040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY08_RS01040	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY08_RS01045	COG0583	DNA-binding transcription factor activity
GPY08_RS01050	COG4771	TonB-dependent receptor
GPY08_RS01050	COG1629	transport
GPY08_RS01070	COG2050	protein possibly involved in aromatic compounds catabolism
GPY08_RS01075	COG0501	Belongs to the peptidase M48B family
GPY08_RS01080	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY08_RS01090	COG0861	Integral membrane protein TerC family
GPY08_RS01100	COG3593	DNA synthesis involved in DNA repair
GPY08_RS01110	COG0583	DNA-binding transcription factor activity
GPY08_RS01115	COG2116	formate transmembrane transporter activity
GPY08_RS01120	COG2353	YceI-like domain
GPY08_RS01125	COG3038	cytochrome b561
GPY08_RS01160	COG0243	molybdopterin cofactor binding
GPY08_RS01165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY08_RS01170	COG0543	2 iron, 2 sulfur cluster binding
GPY08_RS01170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY08_RS01175	COG5002	protein histidine kinase activity
GPY08_RS01175	COG2205	protein histidine kinase activity
GPY08_RS01175	COG0784	Response regulator, receiver
GPY08_RS01200	COG0523	cobalamin synthesis protein
GPY08_RS01215	COG0156	8-amino-7-oxononanoate synthase activity
GPY08_RS01235	COG1609	Transcriptional regulator
GPY08_RS01240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY08_RS01240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY08_RS01245	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY08_RS01250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY08_RS01250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY08_RS01250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY08_RS01255	COG0189	ligase activity
GPY08_RS01255	COG4067	protein conserved in archaea
GPY08_RS01265	COG0602	queuosine metabolic process
GPY08_RS01270	COG1328	CTP reductase activity
GPY08_RS01325	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS01330	COG0745	RESPONSE REGULATOR receiver
GPY08_RS01340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY08_RS01350	COG0583	DNA-binding transcription factor activity
GPY08_RS01365	COG1309	transcriptional regulator
GPY08_RS01370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY08_RS01400	COG1335	isochorismatase
GPY08_RS01405	COG4977	sequence-specific DNA binding
GPY08_RS01410	COG0456	acetyltransferase
GPY08_RS01420	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS01425	COG0494	nUDIX hydrolase
GPY08_RS01435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY08_RS01465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY08_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS01495	COG0454	-acetyltransferase
GPY08_RS01555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY08_RS01560	COG0789	Transcriptional regulator
GPY08_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS01625	COG4628	conserved protein (DUF2132)
GPY08_RS01665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY08_RS01675	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY08_RS01685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY08_RS01695	COG0583	DNA-binding transcription factor activity
GPY08_RS01710	COG3710	Transcriptional regulator
GPY08_RS01715	COG4232	protein-disulfide reductase activity
GPY08_RS01720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY08_RS01725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY08_RS01735	COG1252	NADH dehydrogenase
GPY08_RS01750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY08_RS01760	COG2207	Transcriptional regulator
GPY08_RS01765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY08_RS01765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY08_RS01765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY08_RS01775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY08_RS01790	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPY08_RS01805	COG0110	maltose O-acetyltransferase activity
GPY08_RS01810	COG3706	GGDEF domain
GPY08_RS01820	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY08_RS01825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY08_RS01850	COG4172	Belongs to the ABC transporter superfamily
GPY08_RS01860	COG3437	response regulator, receiver
GPY08_RS01865	COG5002	protein histidine kinase activity
GPY08_RS01865	COG2205	protein histidine kinase activity
GPY08_RS01865	COG0784	Response regulator, receiver
GPY08_RS01870	COG4999	Histidine kinase
GPY08_RS01870	COG3850	Histidine kinase
GPY08_RS01870	COG3437	response regulator, receiver
GPY08_RS01870	COG2205	protein histidine kinase activity
GPY08_RS01905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY08_RS01920	COG2423	ornithine cyclodeaminase activity
GPY08_RS01935	COG0583	DNA-binding transcription factor activity
GPY08_RS01940	COG0435	Glutathione S-transferase
GPY08_RS01945	COG0400	carboxylic ester hydrolase activity
GPY08_RS01950	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS01965	COG1473	amidohydrolase
GPY08_RS01985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY08_RS01990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY08_RS01995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY08_RS02005	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY08_RS02020	COG2721	sulfolactate sulfo-lyase activity
GPY08_RS02075	COG0625	glutathione transferase activity
GPY08_RS02095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY08_RS02105	COG0573	inorganic phosphate transmembrane transporter activity
GPY08_RS02110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY08_RS02130	COG1464	Belongs to the NlpA lipoprotein family
GPY08_RS02135	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY08_RS02135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY08_RS02155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY08_RS02170	COG0653	protein targeting
GPY08_RS02175	COG2814	Major facilitator Superfamily
GPY08_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS02195	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS02205	COG1024	Enoyl-CoA hydratase
GPY08_RS02210	COG1024	Enoyl-CoA hydratase
GPY08_RS02225	COG0183	Belongs to the thiolase family
GPY08_RS02235	COG1960	acyl-CoA dehydrogenase activity
GPY08_RS02240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY08_RS02245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY08_RS02260	COG0450	alkyl hydroperoxide reductase
GPY08_RS02265	COG3634	alkyl hydroperoxide reductase activity
GPY08_RS02275	COG0456	acetyltransferase
GPY08_RS02295	COG1609	Transcriptional regulator
GPY08_RS02295	COG2207	Transcriptional regulator
GPY08_RS02300	COG1454	alcohol dehydrogenase
GPY08_RS02345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY08_RS02360	COG3708	Transcriptional regulator
GPY08_RS02360	COG2207	Transcriptional regulator
GPY08_RS02365	COG4604	ABC transporter, ATP-binding protein
GPY08_RS02370	COG4605	iron ion homeostasis
GPY08_RS02375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY08_RS02395	COG4412	M6 family metalloprotease domain protein
GPY08_RS02395	COG3291	Pkd domain containing protein
GPY08_RS02400	COG5380	lipid catabolic process
GPY08_RS02405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY08_RS02445	COG0840	transmembrane signaling receptor activity
GPY08_RS02470	COG3279	Response regulator of the LytR AlgR family
GPY08_RS02475	COG3275	phosphorelay sensor kinase activity
GPY08_RS02480	COG4989	oxidoreductase activity
GPY08_RS02495	COG0366	Alpha amylase catalytic
GPY08_RS02500	COG3227	Zinc metalloprotease (Elastase)
GPY08_RS02505	COG3047	cAMP biosynthetic process
GPY08_RS02510	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY08_RS02535	COG0251	oxidation-reduction process
GPY08_RS02545	COG2205	protein histidine kinase activity
GPY08_RS02565	COG0583	DNA-binding transcription factor activity
GPY08_RS02575	COG0384	phenazine biosynthesis protein PhzF
GPY08_RS02605	COG1132	(ABC) transporter
GPY08_RS02615	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GPY08_RS02620	COG2246	polysaccharide biosynthetic process
GPY08_RS02635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY08_RS02645	COG0242	peptide deformylase activity
GPY08_RS02655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY08_RS02660	COG2084	Dehydrogenase
GPY08_RS02670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY08_RS02675	COG0583	DNA-binding transcription factor activity
GPY08_RS02710	COG0582	viral genome integration into host DNA
GPY08_RS02720	COG1278	Cold shock
GPY08_RS02740	COG1063	alcohol dehydrogenase
GPY08_RS02745	COG0156	8-amino-7-oxononanoate synthase activity
GPY08_RS02750	COG1012	belongs to the aldehyde dehydrogenase family
GPY08_RS02785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPY08_RS02800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY08_RS02805	COG0363	glucosamine-6-phosphate deaminase activity
GPY08_RS02810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY08_RS02825	COG0583	DNA-binding transcription factor activity
GPY08_RS02840	COG1410	methionine synthase
GPY08_RS02840	COG0646	methionine synthase
GPY08_RS02845	COG0531	amino acid
GPY08_RS02860	COG1473	amidohydrolase
GPY08_RS02865	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY08_RS02870	COG1929	Belongs to the glycerate kinase type-1 family
GPY08_RS02875	COG2610	gluconate transmembrane transporter activity
GPY08_RS02880	COG3835	regulator
GPY08_RS02885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY08_RS02890	COG4533	DNA binding
GPY08_RS02905	COG0840	transmembrane signaling receptor activity
GPY08_RS02965	COG4964	Belongs to the GSP D family
GPY08_RS03030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY08_RS03035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY08_RS03035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY08_RS03045	COG0745	RESPONSE REGULATOR receiver
GPY08_RS03065	COG3036	rescue of stalled ribosome
GPY08_RS03070	COG1278	Cold shock
GPY08_RS03075	COG4681	YaeQ
GPY08_RS03080	COG3706	GGDEF domain
GPY08_RS03085	COG1017	nitric oxide dioxygenase activity
GPY08_RS03085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY08_RS03090	COG3604	Transcriptional regulator
GPY08_RS03105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY08_RS03115	COG0366	Alpha amylase catalytic
GPY08_RS03155	COG2304	oxidoreductase activity
GPY08_RS03170	COG3706	GGDEF domain
GPY08_RS03180	COG0784	Response regulator, receiver
GPY08_RS03180	COG5002	protein histidine kinase activity
GPY08_RS03180	COG2205	protein histidine kinase activity
GPY08_RS03185	COG3706	GGDEF domain
GPY08_RS03185	COG0745	RESPONSE REGULATOR receiver
GPY08_RS03195	COG3724	N-succinylarginine dihydrolase activity
GPY08_RS03200	COG1012	belongs to the aldehyde dehydrogenase family
GPY08_RS03225	COG4948	Mandelate Racemase Muconate Lactonizing
GPY08_RS03250	COG0583	DNA-binding transcription factor activity
GPY08_RS03275	COG3171	Protein conserved in bacteria
GPY08_RS03280	COG0589	response to stress
GPY08_RS03290	COG3530	Putative quorum-sensing-regulated virulence factor
GPY08_RS03300	COG0579	oxidoreductase
GPY08_RS03315	COG2204	response regulator
GPY08_RS03330	COG0383	alpha-mannosidase activity
GPY08_RS03340	COG2188	Transcriptional regulator
GPY08_RS03365	COG3300	MHYT domain
GPY08_RS03365	COG5001	Diguanylate cyclase
GPY08_RS03370	COG2271	Major facilitator Superfamily
GPY08_RS03375	COG0584	glycerophosphoryl diester phosphodiesterase
GPY08_RS03380	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY08_RS03385	COG0583	DNA-binding transcription factor activity
GPY08_RS03395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY08_RS03400	COG1879	ABC-type sugar transport system periplasmic component
GPY08_RS03405	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY08_RS03410	COG1129	ABC transporter
GPY08_RS03415	COG1869	D-ribose catabolic process
GPY08_RS03525	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS03530	COG1846	Transcriptional regulator
GPY08_RS03550	COG1309	transcriptional regulator
GPY08_RS03570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY08_RS03600	COG3842	ATPase activity
GPY08_RS03610	COG2200	EAL domain
GPY08_RS03615	COG0656	L-ascorbic acid biosynthetic process
GPY08_RS03620	COG1902	pentaerythritol trinitrate reductase activity
GPY08_RS03625	COG0583	DNA-binding transcription factor activity
GPY08_RS03630	COG2814	Major facilitator Superfamily
GPY08_RS03650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY08_RS03665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY08_RS03675	COG4702	Belongs to the UPF0303 family
GPY08_RS03680	COG0673	inositol 2-dehydrogenase activity
GPY08_RS03685	COG1349	DNA-binding transcription factor activity
GPY08_RS03690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY08_RS03710	COG3240	lipase activity
GPY08_RS03715	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS03720	COG0583	DNA-binding transcription factor activity
GPY08_RS03735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY08_RS03740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY08_RS03745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY08_RS03750	COG4774	siderophore transport
GPY08_RS03775	COG0840	transmembrane signaling receptor activity
GPY08_RS03785	COG0583	DNA-binding transcription factor activity
GPY08_RS03795	COG1342	Belongs to the UPF0251 family
GPY08_RS03800	COG0778	Nitroreductase
GPY08_RS03805	COG0583	DNA-binding transcription factor activity
GPY08_RS03815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY08_RS03820	COG0697	spore germination
GPY08_RS03835	COG2814	Major facilitator Superfamily
GPY08_RS03840	COG0583	DNA-binding transcription factor activity
GPY08_RS03845	COG3300	MHYT domain
GPY08_RS03845	COG5001	Diguanylate cyclase
GPY08_RS03850	COG0739	heme binding
GPY08_RS03865	COG0659	secondary active sulfate transmembrane transporter activity
GPY08_RS03880	COG2199	diguanylate cyclase activity
GPY08_RS03890	COG0581	inorganic phosphate transmembrane transporter activity
GPY08_RS03895	COG0573	inorganic phosphate transmembrane transporter activity
GPY08_RS03900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY08_RS03905	COG0840	transmembrane signaling receptor activity
GPY08_RS03910	COG0513	Belongs to the DEAD box helicase family
GPY08_RS03920	COG1388	LysM domain
GPY08_RS03920	COG1376	ErfK ybiS ycfS ynhG family protein
GPY08_RS03940	COG0813	purine-nucleoside phosphorylase activity
GPY08_RS03965	COG1566	PFAM secretion protein HlyD family protein
GPY08_RS04000	COG0786	glutamate:sodium symporter activity
GPY08_RS04015	COG1999	signal sequence binding
GPY08_RS04025	COG1162	GTPase activity
GPY08_RS04030	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY08_RS04045	COG4580	involved in the transport of maltose and maltodextrins
GPY08_RS04065	COG1132	(ABC) transporter
GPY08_RS04085	COG3383	formate dehydrogenase (NAD+) activity
GPY08_RS04110	COG1131	(ABC) transporter
GPY08_RS04115	COG2188	Transcriptional regulator
GPY08_RS04125	COG3033	Beta-eliminating lyase
GPY08_RS04130	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY08_RS04135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY08_RS04145	COG0471	metal ion transport
GPY08_RS04170	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GPY08_RS04190	COG3501	Rhs element vgr protein
GPY08_RS04200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY08_RS04205	COG1640	4-alpha-glucanotransferase
GPY08_RS04210	COG0058	SHG alpha-glucan phosphorylase activity
GPY08_RS04215	COG2909	trisaccharide binding
GPY08_RS04230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY08_RS04235	COG1845	cytochrome c oxidase, subunit III
GPY08_RS04240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY08_RS04245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY08_RS04275	COG0217	transcriptional regulatory protein
GPY08_RS04310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY08_RS04315	COG1444	tRNA N-acetyltransferase activity
GPY08_RS04325	COG0745	RESPONSE REGULATOR receiver
GPY08_RS04330	COG0643	Histidine kinase
GPY08_RS04330	COG2198	Histidine kinase
GPY08_RS04335	COG0835	chemotaxis
GPY08_RS04340	COG0835	chemotaxis
GPY08_RS04345	COG0840	transmembrane signaling receptor activity
GPY08_RS04350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY08_RS04360	COG2201	protein-glutamate methylesterase activity
GPY08_RS04445	COG0840	transmembrane signaling receptor activity
GPY08_RS04460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY08_RS04480	COG0583	DNA-binding transcription factor activity
GPY08_RS04485	COG2226	methyltransferase
GPY08_RS04500	COG0724	RNA recognition motif
GPY08_RS04505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY08_RS04510	COG1522	sequence-specific DNA binding
GPY08_RS04515	COG2610	gluconate transmembrane transporter activity
GPY08_RS04520	COG3622	Belongs to the hyi family
GPY08_RS04530	COG3395	kinase activity
GPY08_RS04535	COG2084	Dehydrogenase
GPY08_RS04555	COG0583	DNA-binding transcription factor activity
GPY08_RS04560	COG2910	NAD(P)H-binding
GPY08_RS04575	COG1335	isochorismatase
GPY08_RS04580	COG2207	Transcriptional regulator
GPY08_RS04580	COG1609	Transcriptional regulator
GPY08_RS04595	COG2329	Antibiotic biosynthesis monooxygenase
GPY08_RS04600	COG3304	Inner membrane component domain
GPY08_RS04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY08_RS04645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY08_RS04665	COG2176	DNA-directed DNA polymerase activity
GPY08_RS04685	COG0443	Heat shock 70 kDa protein
GPY08_RS04690	COG0095	Lipoate-protein ligase
GPY08_RS04705	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY08_RS04725	COG3722	fumarate hydratase activity
GPY08_RS04735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY08_RS04735	COG2213	PTS system mannitol-specific
GPY08_RS04740	COG0739	heme binding
GPY08_RS04755	COG0363	glucosamine-6-phosphate deaminase activity
GPY08_RS04780	COG0402	S-adenosylhomocysteine deaminase activity
GPY08_RS04785	COG2259	Doxx family
GPY08_RS04790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY08_RS04795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY08_RS04810	COG1301	dicarboxylic acid transport
GPY08_RS04860	COG1764	response to oxidative stress
GPY08_RS04865	COG1846	Transcriptional regulator
GPY08_RS04870	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY08_RS04890	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS04900	COG1902	pentaerythritol trinitrate reductase activity
GPY08_RS04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY08_RS04915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY08_RS04950	COG0109	protoheme IX farnesyltransferase activity
GPY08_RS04965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY08_RS05015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY08_RS05020	COG0697	spore germination
GPY08_RS05025	COG0477	Major facilitator Superfamily
GPY08_RS05030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY08_RS05035	COG0625	glutathione transferase activity
GPY08_RS05045	COG1942	4-Oxalocrotonate Tautomerase
GPY08_RS05060	COG0583	DNA-binding transcription factor activity
GPY08_RS05080	COG3152	Membrane
GPY08_RS05090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY08_RS05100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY08_RS05125	COG1304	FMN binding
GPY08_RS05130	COG1620	l-lactate permease
GPY08_RS05135	COG0583	DNA-binding transcription factor activity
GPY08_RS05140	COG4172	Belongs to the ABC transporter superfamily
GPY08_RS05150	COG1067	ATP-dependent peptidase activity
GPY08_RS05170	COG0569	domain protein
GPY08_RS05175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY08_RS05185	COG3123	guanosine phosphorylase activity
GPY08_RS05205	COG3501	Rhs element vgr protein
GPY08_RS05305	COG2205	protein histidine kinase activity
GPY08_RS05310	COG0745	RESPONSE REGULATOR receiver
GPY08_RS05315	COG1741	Belongs to the pirin family
GPY08_RS05325	COG5001	Diguanylate cyclase
GPY08_RS05350	COG3706	GGDEF domain
GPY08_RS05370	COG3706	GGDEF domain
GPY08_RS05380	COG1846	Transcriptional regulator
GPY08_RS05385	COG2315	Protein conserved in bacteria
GPY08_RS05390	COG0835	chemotaxis
GPY08_RS05390	COG0784	Response regulator, receiver
GPY08_RS05395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY08_RS05410	COG1942	4-Oxalocrotonate Tautomerase
GPY08_RS05425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY08_RS05445	COG1522	sequence-specific DNA binding
GPY08_RS05455	COG0393	Putative heavy-metal-binding
GPY08_RS05460	COG0823	Involved in the tonB-independent uptake of proteins
GPY08_RS05465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY08_RS05470	COG0534	Mate efflux family protein
GPY08_RS05480	COG1653	transport
GPY08_RS05485	COG3842	ATPase activity
GPY08_RS05490	COG0395	ABC-type sugar transport system, permease component
GPY08_RS05495	COG1175	transmembrane transport
GPY08_RS05515	COG0800	Aldolase
GPY08_RS05520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY08_RS05535	COG1917	Cupin 2, conserved barrel domain protein
GPY08_RS05545	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS05550	COG1414	Transcriptional regulator
GPY08_RS05555	COG0517	IMP dehydrogenase activity
GPY08_RS05575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY08_RS05585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY08_RS05625	COG3842	ATPase activity
GPY08_RS05665	COG1349	DNA-binding transcription factor activity
GPY08_RS05685	COG2354	Protein conserved in bacteria
GPY08_RS05690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY08_RS05695	COG0418	dihydroorotase activity
GPY08_RS05700	COG0633	Ferredoxin
GPY08_RS05700	COG3217	Mosc domain protein beta barrel domain protein
GPY08_RS05735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY08_RS05745	COG0848	biopolymer transport protein
GPY08_RS05750	COG0811	peptide transport
GPY08_RS05755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY08_RS05760	COG3721	Heme iron utilization protein
GPY08_RS05765	COG0748	coenzyme F420 binding
GPY08_RS05775	COG0531	amino acid
GPY08_RS05780	COG1522	sequence-specific DNA binding
GPY08_RS05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY08_RS05815	COG2200	EAL domain
GPY08_RS05840	COG0784	Response regulator, receiver
GPY08_RS05840	COG2205	protein histidine kinase activity
GPY08_RS05840	COG5002	protein histidine kinase activity
GPY08_RS05845	COG5001	Diguanylate cyclase
GPY08_RS05845	COG3300	MHYT domain
GPY08_RS05860	COG1765	OsmC-like protein
GPY08_RS05870	COG2171	N-acyltransferase activity
GPY08_RS05895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY08_RS05905	COG1022	Amp-dependent synthetase and ligase
GPY08_RS05925	COG0745	RESPONSE REGULATOR receiver
GPY08_RS05930	COG0642	Histidine kinase
GPY08_RS05940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY08_RS05945	COG3186	Phenylalanine-4-hydroxylase
GPY08_RS05950	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPY08_RS05955	COG0534	Mate efflux family protein
GPY08_RS05965	COG0861	Integral membrane protein TerC family
GPY08_RS05975	COG0456	acetyltransferase
GPY08_RS05980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY08_RS05985	COG0662	Cupin 2, conserved barrel domain protein
GPY08_RS05995	COG0561	phosphatase activity
GPY08_RS06005	COG0583	DNA-binding transcription factor activity
GPY08_RS06015	COG0784	Response regulator, receiver
GPY08_RS06015	COG3437	response regulator, receiver
GPY08_RS06025	COG0113	porphobilinogen synthase activity
GPY08_RS06040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY08_RS06045	COG2239	Acts as a magnesium transporter
GPY08_RS06055	COG0840	transmembrane signaling receptor activity
GPY08_RS06070	COG4176	ABC-type proline glycine betaine transport system permease component
GPY08_RS06075	COG4175	Glycine betaine
GPY08_RS06085	COG1166	arginine decarboxylase activity
GPY08_RS06095	COG1522	sequence-specific DNA binding
GPY08_RS06110	COG0765	amino acid transport
GPY08_RS06120	COG1686	Belongs to the peptidase S11 family
GPY08_RS06145	COG3338	carbonate dehydratase activity
GPY08_RS06200	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS06205	COG0513	Belongs to the DEAD box helicase family
GPY08_RS06220	COG0840	transmembrane signaling receptor activity
GPY08_RS06235	COG2985	domain, Protein
GPY08_RS06245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY08_RS06265	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS06310	COG3122	Protein conserved in bacteria
GPY08_RS06330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY08_RS06330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPY08_RS06335	COG0509	glycine decarboxylation via glycine cleavage system
GPY08_RS06350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY08_RS06360	COG3706	GGDEF domain
GPY08_RS06365	COG5001	Diguanylate cyclase
GPY08_RS06370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY08_RS06385	COG0546	phosphoglycolate phosphatase activity
GPY08_RS06405	COG0484	heat shock protein binding
GPY08_RS06415	COG5001	Diguanylate cyclase
GPY08_RS06415	COG1716	ATPase activity
GPY08_RS06420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY08_RS06430	COG4181	ATPase activity
GPY08_RS06435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY08_RS06445	COG1984	allophanate hydrolase subunit 2
GPY08_RS06465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY08_RS06470	COG0840	transmembrane signaling receptor activity
GPY08_RS06475	COG0814	amino acid
GPY08_RS06480	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY08_RS06485	COG0513	Belongs to the DEAD box helicase family
GPY08_RS06490	COG1309	transcriptional regulator
GPY08_RS06500	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY08_RS06515	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY08_RS06555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY08_RS06565	COG0463	Glycosyl transferase, family 2
GPY08_RS06575	COG0583	DNA-binding transcription factor activity
GPY08_RS06580	COG0697	spore germination
GPY08_RS06585	COG2207	Transcriptional regulator
GPY08_RS06585	COG1917	Cupin 2, conserved barrel domain protein
GPY08_RS06610	COG0330	HflC and HflK could
GPY08_RS06620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPY08_RS06635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY08_RS06640	COG0583	DNA-binding transcription factor activity
GPY08_RS06645	COG3781	membrane
GPY08_RS06650	COG0243	molybdopterin cofactor binding
GPY08_RS06655	COG1271	oxidase subunit
GPY08_RS06680	COG1070	Carbohydrate kinase
GPY08_RS06690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY08_RS06705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY08_RS06735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY08_RS06770	COG2146	nitrite reductase [NAD(P)H] activity
GPY08_RS06775	COG2116	formate transmembrane transporter activity
GPY08_RS06805	COG2814	Major facilitator Superfamily
GPY08_RS06810	COG3118	belongs to the thioredoxin family
GPY08_RS06815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY08_RS06830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY08_RS06840	COG1596	polysaccharide export
GPY08_RS06865	COG0438	transferase activity, transferring glycosyl groups
GPY08_RS06885	COG0247	lactate metabolic process
GPY08_RS06890	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY08_RS06895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY08_RS06900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY08_RS06905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY08_RS06935	COG4974	Belongs to the 'phage' integrase family
GPY08_RS06955	COG2827	Endonuclease containing a URI domain
GPY08_RS06965	COG1879	ABC-type sugar transport system periplasmic component
GPY08_RS06970	COG5002	protein histidine kinase activity
GPY08_RS06970	COG0784	Response regulator, receiver
GPY08_RS06990	COG1492	cobalamin metabolic process
GPY08_RS06995	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY08_RS07000	COG4149	molybdate abc transporter
GPY08_RS07005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY08_RS07025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY08_RS07030	COG5001	Diguanylate cyclase
GPY08_RS07030	COG3300	MHYT domain
GPY08_RS07035	COG2204	response regulator
GPY08_RS07040	COG3852	Histidine kinase
GPY08_RS07050	COG0174	glutamine synthetase
GPY08_RS07075	COG1490	D-aminoacyl-tRNA deacylase activity
GPY08_RS07080	COG0456	acetyltransferase
GPY08_RS07085	COG2982	Protein involved in outer membrane biogenesis
GPY08_RS07090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY08_RS07095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY08_RS07105	COG3031	protein transport across the cell outer membrane
GPY08_RS07115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY08_RS07120	COG1459	type II secretion system
GPY08_RS07125	COG2165	general secretion pathway protein
GPY08_RS07130	COG2165	general secretion pathway protein
GPY08_RS07135	COG2165	general secretion pathway protein
GPY08_RS07140	COG4795	General secretion pathway protein
GPY08_RS07145	COG3156	type II secretion system protein K
GPY08_RS07150	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY08_RS07155	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY08_RS07165	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY08_RS07170	COG0494	nUDIX hydrolase
GPY08_RS07175	COG0316	Belongs to the HesB IscA family
GPY08_RS07175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPY08_RS07180	COG1040	competence protein
GPY08_RS07195	COG2183	response to ionizing radiation
GPY08_RS07205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY08_RS07210	COG1609	Transcriptional regulator
GPY08_RS07215	COG0129	dihydroxy-acid dehydratase activity
GPY08_RS07220	COG3265	gluconokinase activity
GPY08_RS07225	COG2610	gluconate transmembrane transporter activity
GPY08_RS07235	COG0745	RESPONSE REGULATOR receiver
GPY08_RS07240	COG2205	protein histidine kinase activity
GPY08_RS07245	COG2233	PERMEase
GPY08_RS07250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY08_RS07255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY08_RS07260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY08_RS07270	COG0194	GDP metabolic process
GPY08_RS07275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY08_RS07290	COG3263	regulation of cellular component size
GPY08_RS07300	COG4232	protein-disulfide reductase activity
GPY08_RS07310	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY08_RS07320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY08_RS07335	COG1288	antiporter activity
GPY08_RS07340	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY08_RS07345	COG1027	Aspartate ammonia-lyase
GPY08_RS07350	COG3706	GGDEF domain
GPY08_RS07355	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY08_RS07360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY08_RS07370	COG2205	protein histidine kinase activity
GPY08_RS07375	COG0745	RESPONSE REGULATOR receiver
GPY08_RS07385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY08_RS07390	COG0205	6-phosphofructokinase activity
GPY08_RS07395	COG1494	fructose-1,6-bisphosphatase
GPY08_RS07405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY08_RS07410	COG0527	aspartate kinase activity
GPY08_RS07410	COG0460	homoserine dehydrogenase
GPY08_RS07415	COG0626	cystathionine gamma-synthase activity
GPY08_RS07425	COG0281	malic enzyme
GPY08_RS07430	COG0254	rRNA binding
GPY08_RS07435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY08_RS07440	COG1609	Transcriptional regulator
GPY08_RS07450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY08_RS07460	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY08_RS07465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY08_RS07475	COG0149	triose-phosphate isomerase activity
GPY08_RS07500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY08_RS07505	COG0459	protein refolding
GPY08_RS07510	COG1119	ATPase activity
GPY08_RS07525	COG1509	lysine 2,3-aminomutase activity
GPY08_RS07530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY08_RS07535	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY08_RS07540	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY08_RS07545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY08_RS07550	COG1053	succinate dehydrogenase
GPY08_RS07555	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY08_RS07560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY08_RS07565	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY08_RS07570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY08_RS07575	COG1045	serine acetyltransferase
GPY08_RS07580	COG1695	Transcriptional regulator
GPY08_RS07585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY08_RS07590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY08_RS07595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY08_RS07600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY08_RS07610	COG0165	Argininosuccinate lyase
GPY08_RS07610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY08_RS07620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY08_RS07620	COG0678	peroxiredoxin activity
GPY08_RS07630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY08_RS07665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY08_RS07690	COG0180	Tryptophanyl-tRNA synthetase
GPY08_RS07710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY08_RS07720	COG1012	belongs to the aldehyde dehydrogenase family
GPY08_RS07730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY08_RS07735	COG3954	Phosphoribulokinase
GPY08_RS07755	COG0488	(ABC) transporter
GPY08_RS07760	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY08_RS07770	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GPY08_RS07775	COG1047	Peptidyl-prolyl cis-trans
GPY08_RS07785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY08_RS07790	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY08_RS07795	COG3083	sulfuric ester hydrolase activity
GPY08_RS07800	COG0557	exoribonuclease II activity
GPY08_RS07805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY08_RS07810	COG0051	transcription antitermination factor activity, RNA binding
GPY08_RS07815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY08_RS07820	COG0088	Forms part of the polypeptide exit tunnel
GPY08_RS07825	COG0089	rRNA binding
GPY08_RS07835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY08_RS07840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY08_RS07855	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY08_RS07865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPY08_RS07870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY08_RS07875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY08_RS07880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPY08_RS07885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY08_RS07890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY08_RS07895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPY08_RS07905	COG1841	ribosomal large subunit assembly
GPY08_RS07915	COG0201	protein transport
GPY08_RS07930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY08_RS07935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPY08_RS07940	COG0202	RNA polymerase activity
GPY08_RS07945	COG0203	ribosomal protein L17
GPY08_RS07955	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY08_RS07960	COG3061	Opacity-associated protein A
GPY08_RS07970	COG2153	protein acetylation
GPY08_RS07975	COG0513	Belongs to the DEAD box helicase family
GPY08_RS07985	COG0737	Belongs to the 5'-nucleotidase family
GPY08_RS07995	COG0175	sulfate reduction
GPY08_RS08000	COG2895	sulfate adenylyltransferase (ATP) activity
GPY08_RS08005	COG0490	domain, Protein
GPY08_RS08005	COG0471	metal ion transport
GPY08_RS08010	COG0529	Catalyzes the synthesis of activated sulfate
GPY08_RS08030	COG0577	efflux transmembrane transporter activity
GPY08_RS08030	COG1136	(ABC) transporter
GPY08_RS08045	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY08_RS08050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY08_RS08055	COG0729	surface antigen
GPY08_RS08065	COG2105	PFAM AIG2 family protein
GPY08_RS08075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY08_RS08080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY08_RS08085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY08_RS08090	COG0163	prenyltransferase activity
GPY08_RS08095	COG4143	(ABC) transporter
GPY08_RS08100	COG1178	ABC-type Fe3 transport system permease component
GPY08_RS08105	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY08_RS08110	COG3028	Belongs to the UPF0307 family
GPY08_RS08120	COG2239	Acts as a magnesium transporter
GPY08_RS08125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY08_RS08135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY08_RS08140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY08_RS08150	COG1137	ATPase activity
GPY08_RS08155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY08_RS08165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GPY08_RS08180	COG1127	ABC transporter
GPY08_RS08185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY08_RS08190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY08_RS08195	COG2854	intermembrane phospholipid transfer
GPY08_RS08200	COG3113	response to antibiotic
GPY08_RS08205	COG5007	Belongs to the BolA IbaG family
GPY08_RS08220	COG0251	oxidation-reduction process
GPY08_RS08225	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY08_RS08230	COG0540	Belongs to the ATCase OTCase family
GPY08_RS08235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPY08_RS08240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY08_RS08250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY08_RS08260	COG0564	pseudouridine synthase activity
GPY08_RS08265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY08_RS08270	COG0525	valine-tRNA ligase activity
GPY08_RS08285	COG0795	lipopolysaccharide-transporting ATPase activity
GPY08_RS08290	COG0795	lipopolysaccharide-transporting ATPase activity
GPY08_RS08300	COG3706	GGDEF domain
GPY08_RS08320	COG2199	diguanylate cyclase activity
GPY08_RS08320	COG2200	EAL domain
GPY08_RS08320	COG2203	Gaf domain
GPY08_RS08330	COG3437	response regulator, receiver
GPY08_RS08380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPY08_RS08385	COG0473	3-isopropylmalate dehydrogenase activity
GPY08_RS08390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY08_RS08410	COG0583	DNA-binding transcription factor activity
GPY08_RS08415	COG1022	Amp-dependent synthetase and ligase
GPY08_RS08420	COG0028	Belongs to the TPP enzyme family
GPY08_RS08425	COG0440	acetolactate synthase activity
GPY08_RS08430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY08_RS08440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY08_RS08450	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY08_RS08460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY08_RS08465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY08_RS08480	COG0354	folic acid binding
GPY08_RS08485	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY08_RS08495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY08_RS08500	COG1595	DNA-templated transcription, initiation
GPY08_RS08515	COG3086	response to oxidative stress
GPY08_RS08520	COG0481	GTPase activity
GPY08_RS08530	COG0571	ribonuclease III activity
GPY08_RS08535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY08_RS08540	COG1381	Involved in DNA repair and RecF pathway recombination
GPY08_RS08545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY08_RS08550	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY08_RS08560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY08_RS08565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY08_RS08570	COG3956	TIGRFAM MazG family protein
GPY08_RS08575	COG0504	CTP synthase activity
GPY08_RS08580	COG0148	phosphopyruvate hydratase activity
GPY08_RS08585	COG0617	tRNA 3'-terminal CCA addition
GPY08_RS08600	COG4991	sh3 domain protein
GPY08_RS08605	COG0306	phosphate transporter
GPY08_RS08610	COG1392	Phosphate transport regulator
GPY08_RS08620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY08_RS08635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY08_RS08635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY08_RS08640	COG1538	Outer membrane efflux protein
GPY08_RS08645	COG0494	nUDIX hydrolase
GPY08_RS08650	COG3151	Protein conserved in bacteria
GPY08_RS08660	COG3150	esterase
GPY08_RS08665	COG0187	DNA topoisomerase II activity
GPY08_RS08675	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY08_RS08680	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY08_RS08700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY08_RS08720	COG0716	FMN binding
GPY08_RS08725	COG4974	Belongs to the 'phage' integrase family
GPY08_RS08730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY08_RS08735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY08_RS08740	COG2186	Transcriptional regulator
GPY08_RS08745	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY08_RS08750	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY08_RS08755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY08_RS08770	COG0288	reversible hydration of carbon dioxide
GPY08_RS08775	COG1131	(ABC) transporter
GPY08_RS08780	COG0842	Transport permease protein
GPY08_RS08785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY08_RS08790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY08_RS08795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY08_RS08810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY08_RS08815	COG1489	DNA binding
GPY08_RS08820	COG1643	Atp-dependent helicase
GPY08_RS08825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY08_RS08830	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY08_RS08840	COG3112	Uncharacterised protein family (UPF0231)
GPY08_RS08845	COG0347	Belongs to the P(II) protein family
GPY08_RS08850	COG0004	ammonium transporteR
GPY08_RS08855	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY08_RS08865	COG3842	ATPase activity
GPY08_RS08870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY08_RS08885	COG2971	BadF BadG BcrA BcrD
GPY08_RS08895	COG4608	Belongs to the ABC transporter superfamily
GPY08_RS08900	COG0444	Belongs to the ABC transporter superfamily
GPY08_RS08915	COG0747	negative chemotaxis
GPY08_RS08930	COG0628	permease
GPY08_RS08940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPY08_RS08945	COG0316	Belongs to the HesB IscA family
GPY08_RS08960	COG0739	heme binding
GPY08_RS08965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY08_RS08980	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY08_RS08985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY08_RS08990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY08_RS08995	COG1534	Rna-binding protein
GPY08_RS09005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY08_RS09010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY08_RS09015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY08_RS09020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY08_RS09035	COG0779	Required for maturation of 30S ribosomal subunits
GPY08_RS09040	COG0195	Participates in both transcription termination and antitermination
GPY08_RS09050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY08_RS09055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY08_RS09080	COG0534	Mate efflux family protein
GPY08_RS09105	COG3153	acetyltransferase
GPY08_RS09125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPY08_RS09130	COG0513	Belongs to the DEAD box helicase family
GPY08_RS09150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPY08_RS09155	COG2204	response regulator
GPY08_RS09165	COG0667	Aldo Keto reductase
GPY08_RS09175	COG3066	DNA modification
GPY08_RS09180	COG0494	nUDIX hydrolase
GPY08_RS09190	COG0730	response to heat
GPY08_RS09205	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY08_RS09210	COG0583	DNA-binding transcription factor activity
GPY08_RS09230	COG0196	riboflavin kinase activity
GPY08_RS09235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY08_RS09240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPY08_RS09245	COG1047	Peptidyl-prolyl cis-trans
GPY08_RS09250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY08_RS09255	COG1966	Carbon starvation protein
GPY08_RS09270	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY08_RS09275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY08_RS09285	COG3279	Response regulator of the LytR AlgR family
GPY08_RS09290	COG3275	phosphorelay sensor kinase activity
GPY08_RS09295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY08_RS09300	COG0287	Prephenate dehydrogenase
GPY08_RS09300	COG1605	Chorismate mutase
GPY08_RS09310	COG0488	(ABC) transporter
GPY08_RS09330	COG5001	Diguanylate cyclase
GPY08_RS09335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY08_RS09340	COG0077	Prephenate dehydratase
GPY08_RS09340	COG1605	Chorismate mutase
GPY08_RS09345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY08_RS09355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY08_RS09360	COG0564	pseudouridine synthase activity
GPY08_RS09370	COG0542	response to heat
GPY08_RS09380	COG0590	tRNA wobble adenosine to inosine editing
GPY08_RS09385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY08_RS09390	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GPY08_RS09470	COG0271	Belongs to the BolA IbaG family
GPY08_RS09475	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY08_RS09480	COG1805	sodium ion transport
GPY08_RS09490	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY08_RS09495	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY08_RS09500	COG2871	sodium ion transport
GPY08_RS09505	COG1477	protein flavinylation
GPY08_RS09535	COG0733	neurotransmitter:sodium symporter activity
GPY08_RS09545	COG0189	ligase activity
GPY08_RS09550	COG4067	protein conserved in archaea
GPY08_RS09550	COG0189	ligase activity
GPY08_RS09555	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY08_RS09560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY08_RS09565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY08_RS09575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY08_RS09585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY08_RS09590	COG2252	PERMEase
GPY08_RS09595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY08_RS09610	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY08_RS09615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY08_RS09620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY08_RS09645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY08_RS09650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY08_RS09655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY08_RS09665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY08_RS09670	COG0024	Methionine aminopeptidase
GPY08_RS09695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY08_RS09700	COG0575	Belongs to the CDS family
GPY08_RS09705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY08_RS09710	COG0750	zinc metalloprotease
GPY08_RS09720	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY08_RS09725	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY08_RS09730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY08_RS09740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY08_RS09750	COG0587	DNA-directed DNA polymerase activity
GPY08_RS09755	COG0825	malonyl-CoA metabolic process
GPY08_RS09760	COG0037	tRNA processing
GPY08_RS09770	COG0347	Belongs to the P(II) protein family
GPY08_RS09785	COG0741	lytic transglycosylase activity
GPY08_RS09785	COG1388	LysM domain
GPY08_RS09795	COG2226	methyltransferase
GPY08_RS09800	COG0328	RNA-DNA hybrid ribonuclease activity
GPY08_RS09805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY08_RS09815	COG1960	acyl-CoA dehydrogenase activity
GPY08_RS09820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY08_RS09825	COG0121	glutamine amidotransferase
GPY08_RS09830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY08_RS09835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY08_RS09840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY08_RS09845	COG1187	pseudouridine synthase activity
GPY08_RS09880	COG2608	mercury ion transmembrane transporter activity
GPY08_RS09880	COG2217	Heavy metal translocating P-type atpase
GPY08_RS09885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY08_RS09980	COG4695	Portal protein
GPY08_RS10010	COG2747	anti-sigma28 factor FlgM
GPY08_RS10020	COG0835	chemotaxis
GPY08_RS10020	COG0784	Response regulator, receiver
GPY08_RS10025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY08_RS10030	COG1815	bacterial-type flagellum-dependent cell motility
GPY08_RS10035	COG1558	bacterial-type flagellum-dependent cell motility
GPY08_RS10040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY08_RS10045	COG1749	Flagellar hook protein flgE
GPY08_RS10055	COG4786	Flagellar basal body rod
GPY08_RS10060	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY08_RS10065	COG1706	bacterial-type flagellum-dependent cell motility
GPY08_RS10070	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY08_RS10070	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY08_RS10085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY08_RS10190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY08_RS10200	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY08_RS10205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY08_RS10210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPY08_RS10215	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY08_RS10220	COG3094	Invasion gene expression up-regulator, SirB
GPY08_RS10225	COG2912	Transglutaminase-like superfamily
GPY08_RS10235	COG0737	Belongs to the 5'-nucleotidase family
GPY08_RS10245	COG2233	PERMEase
GPY08_RS10265	COG1393	Belongs to the ArsC family
GPY08_RS10270	COG4783	chaperone-mediated protein folding
GPY08_RS10290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY08_RS10295	COG2716	regulation of RNA biosynthetic process
GPY08_RS10300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY08_RS10305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPY08_RS10315	COG1876	peptidase activity
GPY08_RS10320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY08_RS10325	COG1393	Belongs to the ArsC family
GPY08_RS10365	COG2837	iron assimilation
GPY08_RS10375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY08_RS10380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY08_RS10400	COG1516	flagellar protein fliS
GPY08_RS10410	COG4191	Histidine kinase
GPY08_RS10415	COG2204	response regulator
GPY08_RS10420	COG1677	Flagellar hook-basal body complex protein FliE
GPY08_RS10430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY08_RS10480	COG1987	bacterial-type flagellum assembly
GPY08_RS10500	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY08_RS10505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY08_RS10510	COG0583	DNA-binding transcription factor activity
GPY08_RS10515	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS10520	COG2860	membrane
GPY08_RS10525	COG3101	peptidyl-lysine hydroxylation
GPY08_RS10540	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY08_RS10540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY08_RS10545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY08_RS10550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY08_RS10555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY08_RS10560	COG0735	belongs to the Fur family
GPY08_RS10575	COG1380	Effector of murein hydrolase LrgA
GPY08_RS10580	COG1346	cytolysis
GPY08_RS10595	COG0596	Alpha beta hydrolase
GPY08_RS10600	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY08_RS10605	COG0033	Phosphoglucomutase
GPY08_RS10625	COG2009	succinate dehydrogenase
GPY08_RS10630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY08_RS10645	COG0567	Dehydrogenase, E1 component
GPY08_RS10650	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY08_RS10665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY08_RS10670	COG1121	(ABC) transporter
GPY08_RS10675	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY08_RS10685	COG1918	ferrous iron import across plasma membrane
GPY08_RS10710	COG3102	Protein conserved in bacteria
GPY08_RS10720	COG2062	phosphohistidine phosphatase, SixA
GPY08_RS10735	COG0455	bacterial-type flagellum organization
GPY08_RS10750	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY08_RS10755	COG2198	Histidine kinase
GPY08_RS10755	COG0643	Histidine kinase
GPY08_RS10760	COG2201	protein-glutamate methylesterase activity
GPY08_RS10765	COG1192	Involved in chromosome partitioning
GPY08_RS10775	COG0835	chemotaxis
GPY08_RS10785	COG4133	protoheme IX ABC transporter activity
GPY08_RS10790	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY08_RS10795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY08_RS10800	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY08_RS10805	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY08_RS10810	COG1138	Cytochrome C-type biogenesis protein
GPY08_RS10815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY08_RS10830	COG2853	Lipoprotein
GPY08_RS10850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY08_RS10855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY08_RS10860	COG3384	dioxygenase
GPY08_RS10885	COG0667	Aldo Keto reductase
GPY08_RS10900	COG0583	DNA-binding transcription factor activity
GPY08_RS10905	COG2159	amidohydrolase
GPY08_RS10910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY08_RS10950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPY08_RS10965	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY08_RS10975	COG1448	Aminotransferase
GPY08_RS10990	COG3083	sulfuric ester hydrolase activity
GPY08_RS11000	COG3081	Nucleoid-associated protein
GPY08_RS11010	COG1757	Na H antiporter
GPY08_RS11015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY08_RS11020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY08_RS11025	COG2095	MarC family integral membrane protein
GPY08_RS11030	COG1012	belongs to the aldehyde dehydrogenase family
GPY08_RS11030	COG1454	alcohol dehydrogenase
GPY08_RS11040	COG0659	secondary active sulfate transmembrane transporter activity
GPY08_RS11050	COG1530	ribonuclease E activity
GPY08_RS11055	COG0564	pseudouridine synthase activity
GPY08_RS11060	COG0424	maF-like protein
GPY08_RS11065	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY08_RS11075	COG0416	fatty acid biosynthetic process
GPY08_RS11080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY08_RS11100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY08_RS11105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY08_RS11110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY08_RS11115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY08_RS11120	COG0470	DNA polymerase III
GPY08_RS11125	COG0084	hydrolase, TatD family'
GPY08_RS11160	COG0733	neurotransmitter:sodium symporter activity
GPY08_RS11175	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY08_RS11185	COG1940	carbohydrate kinase activity
GPY08_RS11190	COG0835	chemotaxis
GPY08_RS11190	COG0784	Response regulator, receiver
GPY08_RS11195	COG0587	DNA-directed DNA polymerase activity
GPY08_RS11215	COG0616	signal peptide processing
GPY08_RS11260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY08_RS11265	COG0436	Aminotransferase
GPY08_RS11270	COG1169	isochorismate synthase
GPY08_RS11275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY08_RS11280	COG0596	Alpha beta hydrolase
GPY08_RS11285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY08_RS11290	COG1441	menaquinone biosynthetic process
GPY08_RS11305	COG2855	membrane
GPY08_RS11310	COG0477	Major facilitator Superfamily
GPY08_RS11330	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GPY08_RS11335	COG1388	LysM domain
GPY08_RS11335	COG0741	lytic transglycosylase activity
GPY08_RS11355	COG1815	bacterial-type flagellum-dependent cell motility
GPY08_RS11360	COG1558	bacterial-type flagellum-dependent cell motility
GPY08_RS11365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY08_RS11370	COG1749	Flagellar hook protein flgE
GPY08_RS11380	COG4786	Flagellar basal body rod
GPY08_RS11385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY08_RS11390	COG1706	bacterial-type flagellum-dependent cell motility
GPY08_RS11400	COG1256	bacterial-type flagellum assembly
GPY08_RS11400	COG4786	Flagellar basal body rod
GPY08_RS11420	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GPY08_RS11470	COG0702	epimerase
GPY08_RS11475	COG3015	lipoprotein NlpE involved in copper resistance
GPY08_RS11485	COG1360	Flagellar Motor Protein
GPY08_RS11490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY08_RS11495	COG1191	sigma factor activity
GPY08_RS11500	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY08_RS11520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY08_RS11525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY08_RS11540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY08_RS11550	COG1987	bacterial-type flagellum assembly
GPY08_RS11570	COG2885	chlorophyll binding
GPY08_RS11575	COG2204	response regulator
GPY08_RS11590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY08_RS11620	COG1946	Acyl-CoA thioesterase
GPY08_RS11625	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY08_RS11675	COG0697	spore germination
GPY08_RS11685	COG1278	Cold shock
GPY08_RS11710	COG2207	Transcriptional regulator
GPY08_RS11720	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPY08_RS11720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPY08_RS11725	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPY08_RS11730	COG1881	PFAM PEBP family protein
GPY08_RS11740	COG1733	regulation of RNA biosynthetic process
GPY08_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS11780	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY08_RS11795	COG0642	Histidine kinase
GPY08_RS11800	COG0745	RESPONSE REGULATOR receiver
GPY08_RS11805	COG0671	phosphoesterase, PA-phosphatase related
GPY08_RS11820	COG1368	sulfuric ester hydrolase activity
GPY08_RS11825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY08_RS11830	COG2194	sulfuric ester hydrolase activity
GPY08_RS11875	COG2863	cytochrome
GPY08_RS11880	COG3258	Cytochrome c
GPY08_RS11900	COG1271	oxidase subunit
GPY08_RS11905	COG1294	oxidase, subunit
GPY08_RS11945	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY08_RS11960	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPY08_RS11965	COG1169	isochorismate synthase
GPY08_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS11975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY08_RS11995	COG4592	Periplasmic binding protein
GPY08_RS12005	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY08_RS12020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPY08_RS12025	COG1120	ATPase activity
GPY08_RS12035	COG1609	Transcriptional regulator
GPY08_RS12050	COG0352	thiamine-phosphate diphosphorylase activity
GPY08_RS12060	COG0351	phosphomethylpyrimidine kinase
GPY08_RS12070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY08_RS12075	COG0601	transmembrane transport
GPY08_RS12080	COG0747	negative chemotaxis
GPY08_RS12090	COG1538	Outer membrane efflux protein
GPY08_RS12095	COG1566	PFAM secretion protein HlyD family protein
GPY08_RS12100	COG2814	Major facilitator Superfamily
GPY08_RS12105	COG3708	Transcriptional regulator
GPY08_RS12105	COG2207	Transcriptional regulator
GPY08_RS12115	COG0745	RESPONSE REGULATOR receiver
GPY08_RS12125	COG1263	PTS System
GPY08_RS12125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY08_RS12135	COG1621	beta-fructofuranosidase activity
GPY08_RS12140	COG2199	diguanylate cyclase activity
GPY08_RS12140	COG2200	EAL domain
GPY08_RS12140	COG2202	Pas domain
GPY08_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS12200	COG2986	histidine ammonia-lyase
GPY08_RS12205	COG1216	Glycosyl transferase, family 2
GPY08_RS12215	COG0318	PFAM AMP-dependent synthetase and ligase
GPY08_RS12225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY08_RS12230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY08_RS12235	COG0204	Acyl-transferase
GPY08_RS12235	COG0318	PFAM AMP-dependent synthetase and ligase
GPY08_RS12270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY08_RS12275	COG0444	Belongs to the ABC transporter superfamily
GPY08_RS12290	COG0435	Glutathione S-transferase
GPY08_RS12295	COG3174	membrane
GPY08_RS12300	COG0857	belongs to the CobB CobQ family
GPY08_RS12300	COG0280	phosphate acetyltransferase
GPY08_RS12305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY08_RS12310	COG3092	negative regulation of chromosome organization
GPY08_RS12320	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY08_RS12345	COG0653	protein targeting
GPY08_RS12350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPY08_RS12355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY08_RS12360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPY08_RS12370	COG0243	molybdopterin cofactor binding
GPY08_RS12375	COG1648	precorrin-2 dehydrogenase activity
GPY08_RS12375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY08_RS12395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY08_RS12400	COG1116	anion transmembrane transporter activity
GPY08_RS12415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY08_RS12420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY08_RS12430	COG2226	methyltransferase
GPY08_RS12435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY08_RS12445	COG0501	Belongs to the peptidase M48B family
GPY08_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
GPY08_RS12470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY08_RS12490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY08_RS12495	COG2915	High frequency lysogenization protein hflD homolog
GPY08_RS12500	COG0482	sulfurtransferase activity
GPY08_RS12505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY08_RS12510	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPY08_RS12525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPY08_RS12530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY08_RS12535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPY08_RS12540	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY08_RS12540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY08_RS12550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY08_RS12560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY08_RS12560	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY08_RS12565	COG1187	pseudouridine synthase activity
GPY08_RS12575	COG1278	Cold shock
GPY08_RS12580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY08_RS12585	COG0542	response to heat
GPY08_RS12590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY08_RS12595	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY08_RS12600	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY08_RS12610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPY08_RS12620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY08_RS12625	COG3706	GGDEF domain
GPY08_RS12625	COG0745	RESPONSE REGULATOR receiver
GPY08_RS12630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY08_RS12635	COG0297	glycogen (starch) synthase activity
GPY08_RS12655	COG3070	regulator of competence-specific genes
GPY08_RS12660	COG1609	Transcriptional regulator
GPY08_RS12665	COG3381	protein complex oligomerization
GPY08_RS12670	COG0745	RESPONSE REGULATOR receiver
GPY08_RS12675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY08_RS12680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY08_RS12685	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY08_RS12690	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY08_RS12695	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY08_RS12700	COG0189	ligase activity
GPY08_RS12710	COG0189	ligase activity
GPY08_RS12710	COG4067	protein conserved in archaea
GPY08_RS12715	COG0500	methyltransferase
GPY08_RS12720	COG4106	trans-aconitate 2-methyltransferase activity
GPY08_RS12735	COG1435	thymidine kinase activity
GPY08_RS12740	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY08_RS12745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY08_RS12765	COG2116	formate transmembrane transporter activity
GPY08_RS12770	COG0390	transport system, permease component
GPY08_RS12775	COG4459	periplasmic nitrate reductase
GPY08_RS12780	COG3005	denitrification pathway
GPY08_RS12785	COG0243	molybdopterin cofactor binding
GPY08_RS12805	COG1227	inorganic diphosphatase activity
GPY08_RS12820	COG4172	Belongs to the ABC transporter superfamily
GPY08_RS12830	COG4171	peptide transport system, permease
GPY08_RS12850	COG1842	Phage shock protein A
GPY08_RS12865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY08_RS12880	COG0519	Catalyzes the synthesis of GMP from XMP
GPY08_RS12920	COG0733	neurotransmitter:sodium symporter activity
GPY08_RS12940	COG0564	pseudouridine synthase activity
GPY08_RS12950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY08_RS12955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY08_RS12960	COG4136	ATPase activity
GPY08_RS12965	COG4135	transport system, permease component
GPY08_RS12970	COG4134	Bacterial extracellular solute-binding protein
GPY08_RS12980	COG3313	Fe-S protein
GPY08_RS12990	COG0842	Transport permease protein
GPY08_RS12995	COG1131	(ABC) transporter
GPY08_RS13005	COG0814	amino acid
GPY08_RS13020	COG3706	GGDEF domain
GPY08_RS13025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY08_RS13035	COG1278	Cold shock
GPY08_RS13055	COG3119	arylsulfatase activity
GPY08_RS13060	COG0641	radical SAM
GPY08_RS13065	COG0714	Associated with various cellular activities
GPY08_RS13100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY08_RS13105	COG2205	protein histidine kinase activity
GPY08_RS13110	COG0745	RESPONSE REGULATOR receiver
GPY08_RS13120	COG1061	Type III restriction enzyme res subunit
GPY08_RS13130	COG2814	Major facilitator Superfamily
GPY08_RS13140	COG0702	epimerase
GPY08_RS13145	COG0534	Mate efflux family protein
GPY08_RS13205	COG0840	transmembrane signaling receptor activity
GPY08_RS13215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY08_RS13225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY08_RS13230	COG3265	gluconokinase activity
GPY08_RS13235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY08_RS13265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY08_RS13285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY08_RS13310	COG2989	Protein conserved in bacteria
GPY08_RS13315	COG3108	Peptidase M15
GPY08_RS13320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY08_RS13335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY08_RS13355	COG2197	response regulator
GPY08_RS13360	COG1846	Transcriptional regulator
GPY08_RS13370	COG0840	transmembrane signaling receptor activity
GPY08_RS13375	COG2176	DNA-directed DNA polymerase activity
GPY08_RS13380	COG0517	IMP dehydrogenase activity
GPY08_RS13390	COG1448	Aminotransferase
GPY08_RS13410	COG0840	transmembrane signaling receptor activity
GPY08_RS13415	COG0720	synthase
GPY08_RS13420	COG1538	Outer membrane efflux protein
GPY08_RS13430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY08_RS13435	COG1760	l-serine dehydratase
GPY08_RS13440	COG0814	amino acid
GPY08_RS13445	COG0494	nUDIX hydrolase
GPY08_RS13460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY08_RS13475	COG3106	COG3106 Predicted ATPase
GPY08_RS13485	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPY08_RS13490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY08_RS13510	COG0471	metal ion transport
GPY08_RS13525	COG0583	DNA-binding transcription factor activity
GPY08_RS13530	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY08_RS13535	COG0778	Nitroreductase
GPY08_RS13540	COG2991	Protein conserved in bacteria
GPY08_RS13550	COG3250	beta-galactosidase activity
GPY08_RS13560	COG1129	ABC transporter
GPY08_RS13600	COG2169	Transcriptional regulator
GPY08_RS13600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY08_RS13610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY08_RS13615	COG0372	Belongs to the citrate synthase family
GPY08_RS13620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GPY08_RS13625	COG2828	Protein conserved in bacteria
GPY08_RS13640	COG1566	PFAM secretion protein HlyD family protein
GPY08_RS13645	COG2814	Major facilitator Superfamily
GPY08_RS13665	COG2200	EAL domain
GPY08_RS13675	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY08_RS13685	COG0625	glutathione transferase activity
GPY08_RS13705	COG2731	YhcH YjgK YiaL family protein
GPY08_RS13710	COG0584	glycerophosphoryl diester phosphodiesterase
GPY08_RS13715	COG1349	DNA-binding transcription factor activity
GPY08_RS13720	COG3842	ATPase activity
GPY08_RS13725	COG0395	ABC-type sugar transport system, permease component
GPY08_RS13745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY08_RS13750	COG3040	lipid binding
GPY08_RS13760	COG0811	peptide transport
GPY08_RS13765	COG0811	peptide transport
GPY08_RS13770	COG0848	biopolymer transport protein
GPY08_RS13790	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY08_RS13795	COG1793	dna ligase
GPY08_RS13810	COG0307	riboflavin synthase, alpha
GPY08_RS13830	COG0791	NLP P60 protein
GPY08_RS13835	COG0840	transmembrane signaling receptor activity
GPY08_RS13850	COG1940	carbohydrate kinase activity
GPY08_RS13860	COG0303	'Molybdopterin
GPY08_RS13865	COG0746	molybdenum cofactor guanylyltransferase activity
GPY08_RS13870	COG3842	ATPase activity
GPY08_RS13875	COG4662	Binding-protein-dependent transport system inner membrane component
GPY08_RS13885	COG2204	response regulator
GPY08_RS13890	COG3852	Histidine kinase
GPY08_RS13905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY08_RS13925	COG3381	protein complex oligomerization
GPY08_RS13940	COG0437	4 iron, 4 sulfur cluster binding
GPY08_RS13955	COG0004	ammonium transporteR
GPY08_RS13960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY08_RS13965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY08_RS13970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY08_RS13975	COG1177	transmembrane transport
GPY08_RS13980	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY08_RS13985	COG3842	ATPase activity
GPY08_RS14010	COG0589	response to stress
GPY08_RS14015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY08_RS14030	COG2217	Heavy metal translocating P-type atpase
GPY08_RS14040	COG2010	Cytochrome c
GPY08_RS14055	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY08_RS14090	COG3120	sequence-specific DNA binding
GPY08_RS14095	COG1067	ATP-dependent peptidase activity
GPY08_RS14100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY08_RS14125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY08_RS14125	COG0116	Belongs to the methyltransferase superfamily
GPY08_RS14135	COG0167	dihydroorotate dehydrogenase activity
GPY08_RS14150	COG0308	aminopeptidase N
GPY08_RS14175	COG1956	GAF domain-containing protein
GPY08_RS14185	COG2995	paraquat-inducible protein a
GPY08_RS14190	COG3008	intermembrane lipid transfer
GPY08_RS14195	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPY08_RS14195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY08_RS14200	COG2996	Protein conserved in bacteria
GPY08_RS14215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY08_RS14215	COG0574	Belongs to the PEP-utilizing enzyme family
GPY08_RS14220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY08_RS14230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY08_RS14245	COG1115	amino acid carrier protein
GPY08_RS14280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY08_RS14290	COG1643	Atp-dependent helicase
GPY08_RS14295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY08_RS14305	COG3005	denitrification pathway
GPY08_RS14330	COG3706	GGDEF domain
GPY08_RS14345	COG0443	Heat shock 70 kDa protein
GPY08_RS14350	COG3706	GGDEF domain
GPY08_RS14360	COG3706	GGDEF domain
GPY08_RS14375	COG2999	glutathione oxidoreductase activity
GPY08_RS14395	COG3706	GGDEF domain
GPY08_RS14395	COG0745	RESPONSE REGULATOR receiver
GPY08_RS14415	COG3005	denitrification pathway
GPY08_RS14425	COG0602	queuosine metabolic process
GPY08_RS14430	COG0561	phosphatase activity
GPY08_RS14450	COG0765	amino acid transport
GPY08_RS14455	COG1126	abc transporter atp-binding protein
GPY08_RS14460	COG0670	Belongs to the BI1 family
GPY08_RS14465	COG2920	part of a sulfur-relay system
GPY08_RS14470	COG1254	Belongs to the acylphosphatase family
GPY08_RS14475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY08_RS14480	COG3391	amine dehydrogenase activity
GPY08_RS14500	COG2010	Cytochrome c
GPY08_RS14520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY08_RS14525	COG5002	protein histidine kinase activity
GPY08_RS14545	COG0668	transmembrane transport
GPY08_RS14580	COG1278	Cold shock
GPY08_RS14610	COG4974	Belongs to the 'phage' integrase family
GPY08_RS14805	COG4695	Portal protein
GPY08_RS14845	COG4386	tail sheath protein
GPY08_RS14885	COG3706	GGDEF domain
GPY08_RS14885	COG0745	RESPONSE REGULATOR receiver
GPY08_RS14900	COG0784	Response regulator, receiver
GPY08_RS14900	COG0835	chemotaxis
GPY08_RS14910	COG4565	transcriptional regulatory protein
GPY08_RS14915	COG3290	protein histidine kinase activity
GPY08_RS14930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY08_RS14950	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY08_RS14955	COG3063	Type IV pilus biogenesis stability protein PilW
GPY08_RS14970	COG1451	nucleotide metabolic process
GPY08_RS14980	COG0583	DNA-binding transcription factor activity
GPY08_RS15035	COG4139	cobalamin transport
GPY08_RS15040	COG2988	succinylglutamate desuccinylase activity
GPY08_RS15060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY08_RS15065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GPY08_RS15070	COG0702	epimerase
GPY08_RS15085	COG2925	Exonuclease
GPY08_RS15095	COG1346	cytolysis
GPY08_RS15100	COG0295	cytidine deaminase activity
GPY08_RS15105	COG5001	Diguanylate cyclase
GPY08_RS15105	COG3300	MHYT domain
GPY08_RS15125	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY08_RS15135	COG0500	methyltransferase
GPY08_RS15145	COG0776	regulation of translation
GPY08_RS15150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY08_RS15150	COG0072	phenylalanine-tRNA ligase activity
GPY08_RS15155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY08_RS15170	COG0745	RESPONSE REGULATOR receiver
GPY08_RS15170	COG3706	GGDEF domain
GPY08_RS15175	COG2133	pyrroloquinoline quinone binding
GPY08_RS15205	COG0322	excinuclease ABC activity
GPY08_RS15210	COG2197	response regulator
GPY08_RS15215	COG0417	DNA replication proofreading
GPY08_RS15230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPY08_RS15250	COG1228	amidohydrolase
GPY08_RS15255	COG0010	Belongs to the arginase family
GPY08_RS15265	COG2986	histidine ammonia-lyase
GPY08_RS15285	COG0277	FAD linked oxidase domain protein
GPY08_RS15285	COG0247	lactate metabolic process
GPY08_RS15300	COG2885	chlorophyll binding
GPY08_RS15330	COG1643	Atp-dependent helicase
GPY08_RS15335	COG0281	malic enzyme
GPY08_RS15360	COG0583	DNA-binding transcription factor activity
GPY08_RS15375	COG0640	Transcriptional regulator
GPY08_RS15400	COG2949	membrane
GPY08_RS15410	COG1414	Transcriptional regulator
GPY08_RS15415	COG1414	Transcriptional regulator
GPY08_RS15425	COG1454	alcohol dehydrogenase
GPY08_RS15430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY08_RS15450	COG0492	ferredoxin-NADP+ reductase activity
GPY08_RS15455	COG4988	ABC transporter
GPY08_RS15460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY08_RS15465	COG0739	heme binding
GPY08_RS15485	COG1187	pseudouridine synthase activity
GPY08_RS15490	COG0009	L-threonylcarbamoyladenylate synthase
GPY08_RS15495	COG0613	PHP domain protein
GPY08_RS15505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY08_RS15510	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY08_RS15515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPY08_RS15525	COG0133	tryptophan synthase activity
GPY08_RS15535	COG1301	dicarboxylic acid transport
GPY08_RS15550	COG1607	acyl-coa hydrolase
GPY08_RS15555	COG2350	Protein conserved in bacteria
GPY08_RS15565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY08_RS15585	COG0612	Peptidase, M16
GPY08_RS15605	COG0625	glutathione transferase activity
GPY08_RS15615	COG2771	luxR family
GPY08_RS15615	COG2200	EAL domain
GPY08_RS15620	COG0840	transmembrane signaling receptor activity
GPY08_RS15635	COG1794	racemase activity, acting on amino acids and derivatives
GPY08_RS15640	COG0346	lactoylglutathione lyase activity
GPY08_RS15645	COG5002	protein histidine kinase activity
GPY08_RS15650	COG0745	RESPONSE REGULATOR receiver
GPY08_RS15670	COG0488	(ABC) transporter
GPY08_RS15675	COG1032	radical SAM domain protein
GPY08_RS15680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY08_RS15690	COG3852	Histidine kinase
GPY08_RS15705	COG3070	regulator of competence-specific genes
GPY08_RS15715	COG2431	L-lysine efflux transmembrane transporter activity
GPY08_RS15725	COG0076	glutamate decarboxylase activity
GPY08_RS15730	COG1737	Transcriptional regulator
GPY08_RS15740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY08_RS15750	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY08_RS15775	COG1012	belongs to the aldehyde dehydrogenase family
GPY08_RS15845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY08_RS15850	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY08_RS15855	COG2885	chlorophyll binding
GPY08_RS15875	COG0811	peptide transport
GPY08_RS15880	COG0824	Thioesterase
GPY08_RS15890	COG4890	Cyd operon protein YbgT
GPY08_RS15895	COG1294	oxidase, subunit
GPY08_RS15900	COG1271	oxidase subunit
GPY08_RS15905	COG2255	four-way junction helicase activity
GPY08_RS15915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY08_RS15920	COG0215	cysteine-tRNA ligase activity
GPY08_RS15925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY08_RS15930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY08_RS15935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY08_RS15940	COG3012	SEC-C Motif Domain Protein
GPY08_RS15950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY08_RS15955	COG1199	ATP-dependent helicase activity
GPY08_RS15960	COG3923	Primosomal replication protein n
GPY08_RS15970	COG0840	transmembrane signaling receptor activity
GPY08_RS15975	COG0708	Exodeoxyribonuclease III
GPY08_RS15985	COG4160	amino acid transport
GPY08_RS15990	COG4215	(ABC) transporter
GPY08_RS16010	COG1882	Formate acetyltransferase
GPY08_RS16025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY08_RS16045	COG2766	serine protein kinase
GPY08_RS16050	COG2718	Belongs to the UPF0229 family
GPY08_RS16055	COG2719	SpoVR family
GPY08_RS16060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPY08_RS16075	COG1132	(ABC) transporter
GPY08_RS16080	COG2333	competence protein COMEC
GPY08_RS16080	COG0658	competence protein
GPY08_RS16090	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY08_RS16095	COG1136	(ABC) transporter
GPY08_RS16110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY08_RS16125	COG1252	NADH dehydrogenase
GPY08_RS16155	COG0537	adenosine 5'-monophosphoramidase activity
GPY08_RS16170	COG2186	Transcriptional regulator
GPY08_RS16175	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY08_RS16180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY08_RS16190	COG1522	sequence-specific DNA binding
GPY08_RS16195	COG0686	Belongs to the AlaDH PNT family
GPY08_RS16205	COG0583	DNA-binding transcription factor activity
GPY08_RS16225	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY08_RS16230	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY08_RS16240	COG0539	negative regulation of cytoplasmic translation
GPY08_RS16245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY08_RS16250	COG1555	photosystem II stabilization
GPY08_RS16255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY08_RS16260	COG0776	regulation of translation
GPY08_RS16265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY08_RS16270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY08_RS16280	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY08_RS16290	COG2204	response regulator
GPY08_RS16295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY08_RS16300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY08_RS16305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY08_RS16325	COG0745	RESPONSE REGULATOR receiver
GPY08_RS16330	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY08_RS16335	COG1760	l-serine dehydratase
GPY08_RS16345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY08_RS16345	COG3153	acetyltransferase
GPY08_RS16355	COG1716	ATPase activity
GPY08_RS16355	COG5001	Diguanylate cyclase
GPY08_RS16365	COG4589	Belongs to the CDS family
GPY08_RS16400	COG2197	response regulator
GPY08_RS16405	COG3851	Histidine kinase
GPY08_RS16410	COG2271	Major facilitator Superfamily
GPY08_RS16415	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY08_RS16450	COG0210	DNA helicase
GPY08_RS16455	COG0210	DNA helicase
GPY08_RS16505	COG3550	peptidyl-serine autophosphorylation
GPY08_RS16535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY08_RS16540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY08_RS16550	COG2951	lytic endotransglycosylase activity
GPY08_RS16555	COG3100	YcgL domain-containing protein
GPY08_RS16565	COG2894	cell division
GPY08_RS16570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPY08_RS16580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY08_RS16585	COG0318	PFAM AMP-dependent synthetase and ligase
GPY08_RS16605	COG1214	PFAM Peptidase M22, glycoprotease
GPY08_RS16610	COG1199	ATP-dependent helicase activity
GPY08_RS16620	COG0788	formyltetrahydrofolate deformylase activity
GPY08_RS16635	COG0252	asparaginase activity
GPY08_RS16640	COG3139	Protein of unknown function (DUF1315)
GPY08_RS16650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY08_RS16655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY08_RS16665	COG2226	methyltransferase
GPY08_RS16830	COG4695	Portal protein
GPY08_RS16925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY08_RS16940	COG4974	Belongs to the 'phage' integrase family
GPY08_RS16955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY08_RS16960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY08_RS16965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY08_RS16975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY08_RS16980	COG2832	Protein of unknown function (DUF454)
GPY08_RS16990	COG0745	RESPONSE REGULATOR receiver
GPY08_RS16995	COG0583	DNA-binding transcription factor activity
GPY08_RS17000	COG0778	Nitroreductase
GPY08_RS17005	COG1024	Enoyl-CoA hydratase
GPY08_RS17005	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY08_RS17010	COG0183	Belongs to the thiolase family
GPY08_RS17030	COG2067	long-chain fatty acid transport protein
GPY08_RS17035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY08_RS17050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY08_RS17055	COG2982	Protein involved in outer membrane biogenesis
GPY08_RS17060	COG0572	uridine kinase
GPY08_RS17065	COG0489	protein tyrosine kinase activity
GPY08_RS17070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY08_RS17070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY08_RS17080	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY08_RS17090	COG0517	IMP dehydrogenase activity
GPY08_RS17090	COG0516	GMP reductase activity
GPY08_RS17095	COG3706	GGDEF domain
GPY08_RS17100	COG0314	molybdopterin synthase activity
GPY08_RS17105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY08_RS17110	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY08_RS17115	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY08_RS17120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY08_RS17125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY08_RS17130	COG2198	Histidine kinase
GPY08_RS17135	COG2204	response regulator
GPY08_RS17155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY08_RS17160	COG4657	Part of a membrane complex involved in electron transport
GPY08_RS17165	COG2878	Part of a membrane complex involved in electron transport
GPY08_RS17170	COG4656	Part of a membrane complex involved in electron transport
GPY08_RS17175	COG4658	electron transport chain
GPY08_RS17190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY08_RS17195	COG0346	lactoylglutathione lyase activity
GPY08_RS17210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY08_RS17215	COG2056	Na+-H+ antiporter family
GPY08_RS17220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY08_RS17225	COG1286	toxin biosynthetic process
GPY08_RS17230	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY08_RS17235	COG0285	dihydrofolate synthase activity
GPY08_RS17245	COG0101	tRNA pseudouridine synthase activity
GPY08_RS17255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY08_RS17260	COG1263	PTS System
GPY08_RS17260	COG2190	(PTS) system
GPY08_RS17260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY08_RS17265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY08_RS17270	COG1846	Transcriptional regulator
GPY08_RS17270	COG1940	carbohydrate kinase activity
GPY08_RS17275	COG4651	solute:proton antiporter activity
GPY08_RS17275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY08_RS17280	COG0367	asparagine synthase
GPY08_RS17290	COG3104	oligopeptide transport
GPY08_RS17295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY08_RS17305	COG0326	Molecular chaperone. Has ATPase activity
GPY08_RS17325	COG0622	Phosphoesterase
GPY08_RS17350	COG1090	epimerase
GPY08_RS17355	COG0300	oxidoreductase activity
GPY08_RS17365	COG3118	belongs to the thioredoxin family
GPY08_RS17370	COG0330	HflC and HflK could
GPY08_RS17380	COG0789	Transcriptional regulator
GPY08_RS17395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY08_RS17400	COG3115	cell septum assembly
GPY08_RS17405	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY08_RS17410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY08_RS17420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY08_RS17430	COG2190	(PTS) system
GPY08_RS17435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY08_RS17440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY08_RS17445	COG1702	phosphate starvation-inducible protein PhoH
GPY08_RS17450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY08_RS17455	COG4535	Mg2 and Co2 transporter CorC
GPY08_RS17465	COG2888	peptidyl-tyrosine sulfation
GPY08_RS17475	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY08_RS17485	COG0799	negative regulation of ribosome biogenesis
GPY08_RS17490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY08_RS17495	COG0768	penicillin binding
GPY08_RS17500	COG0772	Belongs to the SEDS family
GPY08_RS17505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY08_RS17510	COG1686	Belongs to the peptidase S11 family
GPY08_RS17515	COG2921	Belongs to the UPF0250 family
GPY08_RS17520	COG0321	lipoyl(octanoyl) transferase activity
GPY08_RS17525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY08_RS17535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY08_RS17545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY08_RS17550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY08_RS17575	COG0366	Alpha amylase catalytic
GPY08_RS17580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY08_RS17580	COG1263	PTS System
GPY08_RS17595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY08_RS17600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY08_RS17610	COG1464	Belongs to the NlpA lipoprotein family
GPY08_RS17615	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY08_RS17635	COG3706	GGDEF domain
GPY08_RS17635	COG0745	RESPONSE REGULATOR receiver
GPY08_RS17640	COG1611	Belongs to the LOG family
GPY08_RS17645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY08_RS17655	COG2363	Small membrane protein
GPY08_RS17665	COG0583	DNA-binding transcription factor activity
GPY08_RS17670	COG0301	tRNA thio-modification
GPY08_RS17670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY08_RS17680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY08_RS17690	COG0142	geranyltranstransferase activity
GPY08_RS17695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY08_RS17700	COG0564	pseudouridine synthase activity
GPY08_RS17705	COG3098	single-species biofilm formation
GPY08_RS17730	COG1671	Belongs to the UPF0178 family
GPY08_RS17735	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY08_RS17740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPY08_RS17745	COG0254	rRNA binding
GPY08_RS17750	COG1720	tRNA m6t6A37 methyltransferase activity
GPY08_RS17755	COG0442	prolyl-tRNA aminoacylation
GPY08_RS17780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY08_RS17785	COG0590	tRNA wobble adenosine to inosine editing
GPY08_RS17795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY08_RS17800	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GPY08_RS17805	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY08_RS17830	COG4969	Belongs to the N-Me-Phe pilin family
GPY08_RS17840	COG0443	Heat shock 70 kDa protein
GPY08_RS17850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY08_RS17855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY08_RS17860	COG0497	DNA recombination
GPY08_RS17865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY08_RS17870	COG2914	Belongs to the UPF0125 (RnfH) family
GPY08_RS17875	COG2867	negative regulation of translational initiation
GPY08_RS17880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY08_RS17905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY08_RS17915	COG0583	DNA-binding transcription factor activity
GPY08_RS17920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY08_RS17925	COG1115	amino acid carrier protein
GPY08_RS17950	COG1584	GPR1 FUN34 yaaH family protein
GPY08_RS17960	COG0519	Catalyzes the synthesis of GMP from XMP
GPY08_RS17960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY08_RS17965	COG0517	IMP dehydrogenase activity
GPY08_RS17965	COG0516	GMP reductase activity
GPY08_RS17970	COG1570	exodeoxyribonuclease VII activity
GPY08_RS17985	COG1160	GTP binding
GPY08_RS17990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY08_RS17995	COG2976	Protein conserved in bacteria
GPY08_RS18000	COG0124	histidyl-tRNA synthetase
GPY08_RS18010	COG1426	Protein conserved in bacteria
GPY08_RS18025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY08_RS18030	COG2975	iron-sulfur cluster assembly
GPY08_RS18035	COG0633	Ferredoxin
GPY08_RS18040	COG0443	Heat shock 70 kDa protein
GPY08_RS18055	COG0822	iron-sulfur transferase activity
GPY08_RS18060	COG1104	cysteine desulfurase activity
GPY08_RS18065	COG1959	2 iron, 2 sulfur cluster binding
GPY08_RS18070	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY08_RS18075	COG0483	inositol monophosphate 1-phosphatase activity
GPY08_RS18085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY08_RS18090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY08_RS18095	COG1862	Preprotein translocase
GPY08_RS18100	COG0343	queuine tRNA-ribosyltransferase activity
GPY08_RS18110	COG0517	IMP dehydrogenase activity
GPY08_RS18125	COG0583	DNA-binding transcription factor activity
GPY08_RS18130	COG0450	alkyl hydroperoxide reductase
GPY08_RS18145	COG0704	Plays a role in the regulation of phosphate uptake
GPY08_RS18150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY08_RS18160	COG0573	inorganic phosphate transmembrane transporter activity
GPY08_RS18165	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY08_RS18170	COG0248	Ppx GppA phosphatase
GPY08_RS18180	COG5002	protein histidine kinase activity
GPY08_RS18185	COG0745	RESPONSE REGULATOR receiver
GPY08_RS18190	COG2974	May be involved in recombination
GPY08_RS18200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY08_RS18215	COG1595	DNA-templated transcription, initiation
GPY08_RS18225	COG3248	Nucleoside-binding outer membrane protein
GPY08_RS18230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY08_RS18235	COG0693	protein deglycase activity
GPY08_RS18240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY08_RS18250	COG2166	iron-sulfur cluster assembly
GPY08_RS18255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY08_RS18260	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY08_RS18270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY08_RS18270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY08_RS18285	COG1074	ATP-dependent DNA helicase activity
GPY08_RS18300	COG0583	DNA-binding transcription factor activity
GPY08_RS18305	COG3141	response to X-ray
GPY08_RS18310	COG2171	N-acyltransferase activity
GPY08_RS18315	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY08_RS18330	COG0569	domain protein
GPY08_RS18330	COG0189	ligase activity
GPY08_RS18345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY08_RS18350	COG2017	converts alpha-aldose to the beta-anomer
GPY08_RS18370	COG0784	Response regulator, receiver
GPY08_RS18370	COG3437	response regulator, receiver
GPY08_RS18420	COG4964	Belongs to the GSP D family
GPY08_RS18460	COG0583	DNA-binding transcription factor activity
GPY08_RS18470	COG0583	DNA-binding transcription factor activity
GPY08_RS18475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY08_RS18480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY08_RS18490	COG0560	Phosphoserine phosphatase
GPY08_RS18500	COG0813	purine-nucleoside phosphorylase activity
GPY08_RS18505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY08_RS18515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY08_RS18520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY08_RS18545	COG0084	hydrolase, TatD family'
GPY08_RS18555	COG1115	amino acid carrier protein
GPY08_RS18570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY08_RS18590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY08_RS18610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY08_RS18625	COG0745	RESPONSE REGULATOR receiver
GPY08_RS18635	COG0784	Response regulator, receiver
GPY08_RS18635	COG5002	protein histidine kinase activity
GPY08_RS18635	COG2198	Histidine kinase
GPY08_RS18645	COG1242	4 iron, 4 sulfur cluster binding
GPY08_RS18660	COG0067	glutamate synthase
GPY08_RS18660	COG0069	glutamate synthase activity
GPY08_RS18660	COG0070	glutamate synthase
GPY08_RS18665	COG0493	'glutamate synthase
GPY08_RS18685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY08_RS18690	COG2860	membrane
GPY08_RS18710	COG0583	DNA-binding transcription factor activity
GPY08_RS18715	COG0730	response to heat
GPY08_RS18725	COG0505	Belongs to the CarA family
GPY08_RS18735	COG0494	nUDIX hydrolase
GPY08_RS18740	COG0653	protein targeting
GPY08_RS18750	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY08_RS18755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY08_RS18760	COG0849	cell division
GPY08_RS18765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY08_RS18775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPY08_RS18790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY08_RS18795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY08_RS18800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY08_RS18810	COG3116	cell division
GPY08_RS18815	COG0275	rRNA processing
GPY08_RS18825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY08_RS18830	COG3107	peptidoglycan biosynthetic process
GPY08_RS18835	COG0792	nuclease activity
GPY08_RS18840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY08_RS18845	COG2823	Periplasmic or secreted lipoprotein
GPY08_RS18850	COG2969	positive regulation of protein catabolic process
GPY08_RS18855	COG0625	glutathione transferase activity
GPY08_RS18860	COG2857	Cytochrome c1
GPY08_RS18865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY08_RS18870	COG0723	plastoquinol--plastocyanin reductase activity
GPY08_RS18875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY08_RS18880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPY08_RS18895	COG3105	Protein conserved in bacteria
GPY08_RS18900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY08_RS18905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY08_RS18910	COG0335	large ribosomal subunit rRNA binding
GPY08_RS18920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY08_RS18930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY08_RS18935	COG4137	Cytochrome C assembly protein
GPY08_RS18940	COG4536	flavin adenine dinucleotide binding
GPY08_RS18945	COG1854	S-ribosylhomocysteine lyase activity
GPY08_RS18960	COG0612	Peptidase, M16
GPY08_RS18970	COG1063	alcohol dehydrogenase
GPY08_RS18975	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY08_RS18980	COG0511	ligase activity, forming carbon-carbon bonds
GPY08_RS18980	COG5016	pyruvate
GPY08_RS18985	COG3630	sodium ion export across plasma membrane
GPY08_RS19035	COG0527	aspartate kinase activity
GPY08_RS19040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY08_RS19050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY08_RS19055	COG1546	Belongs to the CinA family
GPY08_RS19060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY08_RS19065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY08_RS19080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY08_RS19095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY08_RS19100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY08_RS19105	COG1968	undecaprenyl-diphosphatase activity
GPY08_RS19110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY08_RS19115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY08_RS19120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY08_RS19125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY08_RS19130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY08_RS19135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY08_RS19140	COG1610	YqeY-like protein
GPY08_RS19150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY08_RS19210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY08_RS19215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY08_RS19220	COG1349	DNA-binding transcription factor activity
GPY08_RS19225	COG0469	pyruvate kinase activity
GPY08_RS19230	COG3706	GGDEF domain
GPY08_RS19255	COG0668	transmembrane transport
GPY08_RS19260	COG0191	fructose-bisphosphate aldolase activity
GPY08_RS19265	COG0126	phosphoglycerate kinase activity
GPY08_RS19270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY08_RS19275	COG4771	TonB-dependent receptor
GPY08_RS19280	COG0583	DNA-binding transcription factor activity
GPY08_RS19285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY08_RS19305	COG2356	endonuclease I
GPY08_RS19310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY08_RS19315	COG0189	ligase activity
GPY08_RS19320	COG1678	Uncharacterized ACR, COG1678
GPY08_RS19325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY08_RS19340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY08_RS19345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY08_RS19350	COG0762	integral membrane protein
GPY08_RS19355	COG1872	DUF167
GPY08_RS19370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY08_RS19375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPY08_RS19380	COG2066	Belongs to the glutaminase family
GPY08_RS19385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY08_RS19390	COG1194	a g-specific adenine glycosylase
GPY08_RS19395	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY08_RS19400	COG0741	lytic transglycosylase activity
GPY08_RS19425	COG0840	transmembrane signaling receptor activity
GPY08_RS19455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY08_RS19460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY08_RS19465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY08_RS19480	COG2967	ApaG domain
GPY08_RS19495	COG3610	response to peptide
GPY08_RS19500	COG2966	Psort location CytoplasmicMembrane, score
GPY08_RS19505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY08_RS19510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPY08_RS19515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY08_RS19525	COG0531	amino acid
GPY08_RS19530	COG0039	L-malate dehydrogenase activity
GPY08_RS19550	COG0589	response to stress
GPY08_RS19570	COG0312	modulator of DNA gyrase
GPY08_RS19575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY08_RS19580	COG3164	Protein of unknown function
GPY08_RS19585	COG1530	ribonuclease E activity
GPY08_RS19590	COG0424	maF-like protein
GPY08_RS19595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY08_RS19600	COG1792	Involved in formation and maintenance of cell shape
GPY08_RS19605	COG1077	Cell shape determining protein MreB Mrl
GPY08_RS19695	COG2200	EAL domain
GPY08_RS19695	COG2199	diguanylate cyclase activity
GPY08_RS19700	COG0629	single-stranded DNA binding
GPY08_RS19715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY08_RS19730	COG0527	aspartate kinase activity
GPY08_RS19735	COG0646	methionine synthase
GPY08_RS19735	COG1410	methionine synthase
GPY08_RS19800	COG0175	sulfate reduction
GPY08_RS19830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY08_RS19835	COG0735	belongs to the Fur family
GPY08_RS19845	COG0166	Belongs to the GPI family
GPY08_RS19850	COG0432	Pfam Uncharacterised protein family UPF0047
GPY08_RS19855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY08_RS19870	COG0359	binds to the 23S rRNA
GPY08_RS19880	COG2965	DNA replication, synthesis of RNA primer
GPY08_RS19885	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY08_RS19895	COG2906	2 iron, 2 sulfur cluster binding
GPY08_RS19905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY08_RS19910	COG0049	tRNA binding
GPY08_RS19920	COG2168	tRNA wobble position uridine thiolation
GPY08_RS19925	COG2923	Belongs to the DsrF TusC family
GPY08_RS19935	COG2964	Protein conserved in bacteria
GPY08_RS19940	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY08_RS19950	COG2900	Belongs to the SlyX family
GPY08_RS19955	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY08_RS19960	COG0330	HflC and HflK could
GPY08_RS19965	COG0330	HflC and HflK could
GPY08_RS19970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY08_RS19975	COG1923	regulation of RNA biosynthetic process
GPY08_RS19980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY08_RS19985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY08_RS19995	COG0802	atpase or kinase
GPY08_RS20000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY08_RS20055	COG1162	GTPase activity
GPY08_RS20060	COG0688	phosphatidylethanolamine metabolic process
GPY08_RS20080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY08_RS20085	COG4942	peptidase
GPY08_RS20105	COG2816	NAD+ diphosphatase activity
GPY08_RS20110	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY08_RS20115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY08_RS20120	COG0085	RNA polymerase activity
GPY08_RS20130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY08_RS20135	COG0081	regulation of translation
GPY08_RS20140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPY08_RS20145	COG0250	Participates in transcription elongation, termination and antitermination
GPY08_RS20150	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY08_RS20180	COG1072	(Pantothenic acid kinase))
GPY08_RS20190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY08_RS20200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY08_RS20245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY08_RS20255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY08_RS20260	COG3118	belongs to the thioredoxin family
GPY08_RS20265	COG0513	Belongs to the DEAD box helicase family
GPY08_RS20270	COG0248	Ppx GppA phosphatase
GPY08_RS20275	COG2198	Histidine kinase
GPY08_RS20275	COG0784	Response regulator, receiver
GPY08_RS20275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY08_RS20275	COG2205	protein histidine kinase activity
GPY08_RS20280	COG2814	Major facilitator Superfamily
GPY08_RS20295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY08_RS20300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY08_RS20305	COG0511	ligase activity, forming carbon-carbon bonds
GPY08_RS20310	COG0439	Biotin carboxylase
GPY08_RS20315	COG2264	protein methyltransferase activity
GPY08_RS20320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY08_RS20325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY08_RS20330	COG0840	transmembrane signaling receptor activity
GPY08_RS20335	COG0789	Transcriptional regulator
GPY08_RS20345	COG0138	bifunctional purine biosynthesis protein purh
GPY08_RS20350	COG0151	Belongs to the GarS family
GPY08_RS20360	COG0776	regulation of translation
GPY08_RS20365	COG1253	flavin adenine dinucleotide binding
GPY08_RS20370	COG0668	transmembrane transport
GPY08_RS20375	COG3068	Protein conserved in bacteria
GPY08_RS20380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY08_RS20385	COG1573	uracil-dna glycosylase
GPY08_RS20390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY08_RS20395	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GPY08_RS20405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY08_RS20435	COG0367	asparagine synthase
GPY08_RS20475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY08_RS20485	COG1560	Kdo2-lipid A biosynthetic process
GPY08_RS20500	COG0859	PFAM glycosyl transferase family 9
GPY08_RS20505	COG0859	PFAM glycosyl transferase family 9
GPY08_RS20510	COG1519	Transferase
GPY08_RS20515	COG0438	transferase activity, transferring glycosyl groups
GPY08_RS20525	COG0859	PFAM glycosyl transferase family 9
GPY08_RS20530	COG0463	Glycosyl transferase, family 2
GPY08_RS20535	COG0438	transferase activity, transferring glycosyl groups
GPY08_RS20540	COG0438	transferase activity, transferring glycosyl groups
GPY08_RS20545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY08_RS20560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPY08_RS20570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPY08_RS20590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY08_RS20595	COG1309	transcriptional regulator
GPY08_RS20600	COG1560	Kdo2-lipid A biosynthetic process
GPY08_RS20605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPY08_RS20610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY08_RS20680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY08_RS20685	COG1120	ATPase activity
GPY08_RS20690	COG1132	(ABC) transporter
GPY08_RS20705	COG0514	ATP-dependent DNA helicase (RecQ)
GPY08_RS20710	COG2962	Rard protein
GPY08_RS20720	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS20730	COG0210	DNA helicase
GPY08_RS20765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY08_RS20770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY08_RS20810	COG3550	peptidyl-serine autophosphorylation
GPY08_RS20860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY08_RS20865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY08_RS20875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY08_RS20885	COG0747	negative chemotaxis
GPY08_RS20890	COG4172	Belongs to the ABC transporter superfamily
GPY08_RS20925	COG0210	DNA helicase
GPY08_RS20935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY08_RS20940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY08_RS20955	COG0583	DNA-binding transcription factor activity
GPY08_RS21000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY08_RS21015	COG0408	coproporphyrinogen oxidase activity
GPY08_RS21030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY08_RS21035	COG0551	DNA topoisomerase type I activity
GPY08_RS21040	COG2922	Belongs to the Smg family
GPY08_RS21050	COG1652	LysM domain
GPY08_RS21055	COG0242	peptide deformylase activity
GPY08_RS21065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY08_RS21065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY08_RS21070	COG0569	domain protein
GPY08_RS21075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY08_RS21085	COG1272	protein, Hemolysin III
GPY08_RS21090	COG4326	sporulation control protein
GPY08_RS21100	COG3084	Protein conserved in bacteria
GPY08_RS21110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY08_RS21115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY08_RS21120	COG0204	Acyl-transferase
GPY08_RS21125	COG0606	chelatase, subunit chli
GPY08_RS21135	COG3978	acetolactate synthase activity
GPY08_RS21140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY08_RS21155	COG0604	alcohol dehydrogenase
GPY08_RS21185	COG0752	glycyl-tRNA synthetase alpha subunit
GPY08_RS21190	COG0751	glycine-tRNA ligase activity
GPY08_RS21195	COG3977	Valine--pyruvate aminotransferase
GPY08_RS21200	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY08_RS21205	COG0187	DNA topoisomerase II activity
GPY08_RS21210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPY08_RS21215	COG0592	DNA-directed DNA polymerase activity
GPY08_RS21220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY08_RS21235	COG1126	abc transporter atp-binding protein
GPY08_RS21240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPY08_RS21250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY08_RS21255	COG0706	membrane insertase activity
GPY08_RS21260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPY08_RS21265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY08_RS21270	COG0445	tRNA wobble uridine modification
GPY08_RS21275	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY08_RS21280	COG1192	Involved in chromosome partitioning
GPY08_RS21285	COG1475	DNA binding
GPY08_RS21290	COG3312	ion transport
GPY08_RS21295	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY08_RS21305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY08_RS21310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY08_RS21320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY08_RS21325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY08_RS21330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY08_RS21345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY08_RS21350	COG2814	Major facilitator Superfamily
GPY08_RS21355	COG0583	DNA-binding transcription factor activity
GPY08_RS21360	COG0183	Belongs to the thiolase family
GPY08_RS21370	COG1739	Uncharacterized protein family UPF0029
GPY08_RS21430	COG2132	Multicopper oxidase
GPY08_RS21435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPY08_RS21440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPY08_RS21445	COG0352	thiamine-phosphate diphosphorylase activity
GPY08_RS21450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY08_RS21455	COG2022	thiamine diphosphate biosynthetic process
GPY08_RS21455	COG2104	thiamine diphosphate biosynthetic process
GPY08_RS21465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPY08_RS21500	COG0006	proline dipeptidase activity
GPY08_RS21500	COG0006	proline dipeptidase activity
GPY08_RS21520	COG1522	sequence-specific DNA binding
GPY08_RS21525	COG5001	Diguanylate cyclase
GPY08_RS21525	COG5002	protein histidine kinase activity
GPY08_RS21530	COG0742	ribosomal rna small subunit methyltransferase
GPY08_RS21545	COG0589	response to stress
GPY08_RS21550	COG1528	Iron-storage protein
GPY08_RS21560	COG2081	HI0933 family
GPY08_RS21565	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY08_RS21570	COG1129	ABC transporter
GPY08_RS21575	COG1879	ABC-type sugar transport system periplasmic component
GPY08_RS21580	COG1069	ribulokinase activity
GPY08_RS21585	COG0235	Class ii aldolase
GPY08_RS21590	COG2160	L-arabinose isomerase activity
GPY08_RS21615	COG1322	Protein conserved in bacteria
GPY08_RS21620	COG2226	methyltransferase
GPY08_RS21625	COG3165	ubiquinone biosynthetic process from chorismate
GPY08_RS21630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY08_RS21640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPY08_RS21645	COG0805	protein transport
GPY08_RS21650	COG0084	hydrolase, TatD family'
GPY08_RS21660	COG0456	acetyltransferase
GPY08_RS21665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY08_RS21665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY08_RS21670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY08_RS21695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY08_RS21700	COG3071	HemY protein
GPY08_RS21705	COG2959	enzyme of heme biosynthesis
GPY08_RS21720	COG3072	Adenylate cyclase
GPY08_RS21735	COG0019	diaminopimelate decarboxylase activity
GPY08_RS21740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPY08_RS21750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY08_RS21755	COG1011	Hydrolase
GPY08_RS21760	COG2200	EAL domain
GPY08_RS21760	COG2199	diguanylate cyclase activity
GPY08_RS21760	COG3287	FIST C domain
GPY08_RS21780	COG0561	phosphatase activity
GPY08_RS21785	COG2267	carboxylic ester hydrolase activity
GPY08_RS21790	COG1280	lysine exporter protein (LysE YggA)
GPY08_RS21800	COG0640	Transcriptional regulator
GPY08_RS21820	COG0783	Belongs to the Dps family
GPY08_RS21850	COG2095	MarC family integral membrane protein
GPY08_RS21860	COG0742	ribosomal rna small subunit methyltransferase
GPY08_RS21865	COG0552	protein localization to endoplasmic reticulum
GPY08_RS21870	COG2884	Cell division ATP-binding protein ftsE
GPY08_RS21875	COG2177	Part of the ABC transporter FtsEX involved in
GPY08_RS21880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY08_RS21890	COG0705	Rhomboid family
GPY08_RS21895	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY08_RS21900	COG3161	chorismate lyase activity
GPY08_RS21905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY08_RS21910	COG2937	Belongs to the GPAT DAPAT family
GPY08_RS21915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY08_RS21920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY08_RS21930	COG0534	Mate efflux family protein
GPY08_RS21950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY08_RS21965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis